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1. Wahdan-Alaswad RS, Song K, Krebs TL, Shola DT, Gomez JA, Matsuyama S, Danielpour D: Insulin-like growth factor I suppresses bone morphogenetic protein signaling in prostate cancer cells by activating mTOR signaling. Cancer Res; 2010 Nov 15;70(22):9106-17
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  • Insulin-like growth factor (IGF) I and bone morphogenetic proteins (BMP) are critical regulators of prostate tumor cell growth.
  • Similarly, IGF-I suppressed BMP4-induced transcription of the Id1, Id2, and Id3 genes that are crucially involved in prostate tumor progression through PI3K-dependent and mTORC1/2-dependent mechanisms.

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  • [Copyright] Copyright © 2010 AACR.
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  • (PMID = 21062988.001).
  • [ISSN] 1538-7445
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA102074-05; United States / NCI NIH HHS / CA / R01 CA134878-02; United States / NCI NIH HHS / CA / CA102074-05; United States / NIA NIH HHS / AG / R01AG031903; United States / NCI NIH HHS / CA / 5T32CA059366-15; United States / NCI NIH HHS / CA / R01 CA102074-01A1; United States / NCI NIH HHS / CA / R01 CA102074; United States / NIA NIH HHS / AG / R01 AG031903; United States / NCI NIH HHS / CA / R01CA102074; United States / NCI NIH HHS / CA / P30 CA043703; United States / NCI NIH HHS / CA / T32 CA059366; United States / NCI NIH HHS / CA / 1F31CA142311-01; United States / NCI NIH HHS / CA / CA102074-01A1; United States / NCI NIH HHS / CA / P30 CA-43703; United States / NCI NIH HHS / CA / CA092102-05; United States / NCI NIH HHS / CA / R01 CA092102; United States / NCI NIH HHS / CA / R01CA092102; United States / NCI NIH HHS / CA / CA134878-02; United States / NCI NIH HHS / CA / R01 CA092102-05; United States / NCI NIH HHS / CA / P30 CA43703; United States / NCI NIH HHS / CA / F31 CA142311; United States / NCI NIH HHS / CA / R01 CA134878
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bone Morphogenetic Protein 4; 0 / Inhibitor of Differentiation Protein 1; 0 / Smad Proteins; 0 / Transforming Growth Factor beta; 67763-96-6 / Insulin-Like Growth Factor I; EC 2.7.1.1 / TOR Serine-Threonine Kinases
  • [Other-IDs] NLM/ NIHMS237682; NLM/ PMC3285447
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2. Health Quality Ontario: Cancer screening with digital mammography for women at average risk for breast cancer, magnetic resonance imaging (MRI) for women at high risk: an evidence-based analysis. Ont Health Technol Assess Ser; 2010;10(3):1-55
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  • Treatment options for breast cancer vary with the stage of disease (based on tumor size, involvement of surrounding tissue, and number of affected axillary lymph nodes) and its pathology, and may include a combination of surgery, chemotherapy and/or radiotherapy.
  • Surgery is the first-line intervention for biopsy-confirmed tumors.
  • The subsequent use of radiation, chemotherapy or hormonal treatments is dependent on the histopathologic characteristics of the tumor and the type of surgery.
  • There is controversy regarding the optimal treatment of DCIS, which is considered a noninvasive tumour.
  • Genetic carriers for this disease, primarily women with BRCA1 or BRCA2 mutations, have a lifetime probability of approximately 85% of developing breast cancer.
  • Part I of this review (March 2006) addressed the effectiveness of screening mammography in 40 to 49 year old average-risk women.
  • The subject headings and keywords searched included breast cancer, breast neoplasms, mass screening, digital mammography, magnetic resonance imaging.
  • The detailed search strategies can be viewed in Appendix 1.

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  • (PMID = 23074406.001).
  • [ISSN] 1915-7398
  • [Journal-full-title] Ontario health technology assessment series
  • [ISO-abbreviation] Ont Health Technol Assess Ser
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC3377503
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3. Modlin IM, Kidd M, Latich I, Zikusoka MN, Shapiro MD: Current status of gastrointestinal carcinoids. Gastroenterology; 2005 May;128(6):1717-51
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  • Carcinoids are classified based on organ site and cell of origin and occur most frequently in the GI (67%) where they are most common in small intestine (25%), appendix (12%), and rectum (14%).
  • Local manifestations--mass, bleeding, obstruction, or perforation--reflect invasion or tumor-induced fibrosis and often result in incidental detection at emergency surgery.
  • Biochemical diagnosis is established by elevation of plasma chromogranin A (CgA), serotonin, or urinary 5-hydroxyindoleacetic acid (5-HIAA), while topographic localization is by Octreoscan, computerized axial tomography (CAT) scan, or endoscopy/ultrasound.
  • Intravenously administered receptor-targeted radiolabeled somatostatin analogs are of use in disseminated disease.
  • Overall 5-year survival for carcinoids of the appendix is 98%, gastric (types I/II) is 81%, rectum is 87%, small intestinal is 60%, colonic carcinoids is 62%, and gastric type III/IV is 33%.
  • [MeSH-major] Carcinoid Tumor / pathology. Carcinoid Tumor / therapy. Gastrointestinal Neoplasms / pathology. Gastrointestinal Neoplasms / therapy


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4. Pal R, Datta A, Fornace AJ Jr, Bittner ML, Dougherty ER: Boolean relationships among genes responsive to ionizing radiation in the NCI 60 ACDS. Bioinformatics; 2005 Apr 15;21(8):1542-9
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  • AVAILABILITY: The appendix is available at http://gsp.tamu.edu/Publications/supplement.htm CONTACT: edward@ee.tamu.edu.
  • [MeSH-major] Gene Expression Profiling / methods. Gene Expression Regulation, Neoplastic / radiation effects. Logistic Models. Models, Biological. Neoplasm Proteins / metabolism. Neoplasms / metabolism. Radiation, Ionizing. Signal Transduction / radiation effects
  • [MeSH-minor] Cell Line, Tumor / metabolism. Cell Line, Tumor / radiation effects. Computer Simulation. Humans. Multivariate Analysis

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  • (PMID = 15598836.001).
  • [ISSN] 1367-4803
  • [Journal-full-title] Bioinformatics (Oxford, England)
  • [ISO-abbreviation] Bioinformatics
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Neoplasm Proteins
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5. Yamada A, Yamamoto H, Arai O, Kiyosuke Y, Tsuji Y, Nakatsuji M, Fukatsu H, Miyoshi M, Kono H, Mouri H, Matsueda K, Tezen T, Shimamura J, Tsukayam C: [A case of goblet cell carcinoid of the appendix presented as a metastatic ovarian tumor and peritoneal dissemination, and diagnosed by autopsy]. Nihon Shokakibyo Gakkai Zasshi; 2005 Jul;102(7):905-11
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  • [Title] [A case of goblet cell carcinoid of the appendix presented as a metastatic ovarian tumor and peritoneal dissemination, and diagnosed by autopsy].
  • [MeSH-major] Appendiceal Neoplasms / pathology. Carcinoid Tumor / secondary. Ovarian Neoplasms / secondary. Peritoneal Neoplasms / secondary

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  • (PMID = 16038438.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 12
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6. Cao W, Bover L, Cho M, Wen X, Hanabuchi S, Bao M, Rosen DB, Wang YH, Shaw JL, Du Q, Li C, Arai N, Yao Z, Lanier LL, Liu YJ: Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction. J Exp Med; 2009 Jul 6;206(7):1603-14
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  • [Title] Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction.
  • Plasmacytoid dendritic cells (pDCs) produce copious type I interferon (IFN) upon sensing nucleic acids through Toll-like receptor (TLR) 7 and TLR9.
  • Uncontrolled pDC activation and IFN production are implicated in lymphopenia and autoimmune diseases; therefore, a mechanism controlling pDC IFN production is essential.
  • Human pDCs specifically express an orphan receptor, immunoglobulin-like transcript 7 (ILT7).
  • Here, we discovered an ILT7 ligand expressed by human cell lines and identified it as bone marrow stromal cell antigen 2 (BST2; CD317).
  • BST2 directly binds to purified ILT7 protein, initiates signaling via the ILT7-FcepsilonRIgamma complex, and strongly inhibits production of IFN and proinflammatory cytokines by pDCs.
  • Readily induced by IFN and other proinflammatory cytokines, BST2 may modulate the human pDC's IFN responses through ILT7 in a negative feedback fashion.

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  • (PMID = 19564354.001).
  • [ISSN] 1540-9538
  • [Journal-full-title] The Journal of experimental medicine
  • [ISO-abbreviation] J. Exp. Med.
  • [Language] ENG
  • [Grant] United States / NIAID NIH HHS / AI / R01 AI059718; United States / NIAID NIH HHS / AI / AI068129; United States / NIAID NIH HHS / AI / R01 AI068129; United States / NIAID NIH HHS / AI / R01 AI074809; United States / NIAID NIH HHS / AI / AI 059718; United States / NIAID NIH HHS / AI / AI074809
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / BST2 protein, human; 0 / Cytokines; 0 / GPI-Linked Proteins; 0 / Interferon-alpha; 0 / LILRA4 protein, human; 0 / Ligands; 0 / Membrane Glycoproteins; 0 / Receptors, Immunologic; 0 / Recombinant Fusion Proteins; 0 / TLR7 protein, human; 0 / TLR9 protein, human; 0 / Toll-Like Receptor 7; 0 / Toll-Like Receptor 9
  • [Other-IDs] NLM/ PMC2715090
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7. Schalamon J, Ainoedhofer H, Schleef J, Singer G, Haxhija EQ, Höllwarth ME: Management of acute scrotum in children--the impact of Doppler ultrasound. J Pediatr Surg; 2006 Aug;41(8):1377-80
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  • BACKGROUND: Investigation of the value of scrotal Doppler ultrasound (DUS) in the diagnosis of acute scrotum and its impact on the treatment strategy was undertaken.
  • RESULTS: In 66 children (84%), the result of DUS determined the management; 26 children with hyperperfusion (epididymitis and orchitis), 18 children with appendix testis torsion (ATT), and 9 children with normal perfusion (edema and hematoma) were treated nonoperatively.
  • The follow-up examination revealed no testicular atrophy and confirmed the primary diagnosis.
  • Ten children without testicular perfusion and suspected torsion and 3 children with orchitis and pyocele were surgically explored, and again, the initial DUS diagnosis was verified.
  • In 3 additional patients, a testicular tumor was suspected.
  • All these 13 children underwent surgical exploration, revealing inflammation (epididymitis) in 6 children and acute ATT in 4 children, whereas the suspected tumor emerged as postacute ATT in 3 boys.

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  • (PMID = 16863840.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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8. Lee JH, Kong SK, Wu ZS, Wu Q, Choe J, Cho HY, Ha SY, Kee SH, Kim YS: Class II beta-tubulin is a novel marker for human tonsillar M cells and follicular dendritic cells. J Oral Pathol Med; 2010 Aug 1;39(7):533-9
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  • Among these genes, we here describe class II beta-tubulin as a new marker for human tonsillar M cells and follicular dendritic cells (FDCs), and present its usefulness for diagnosis of angioimmunoblastic T-cell lymphomas (AILTs).
  • [MeSH-major] Biomarkers, Tumor / analysis. Dendritic Cells, Follicular / pathology. Palatine Tonsil / pathology. Tubulin / analysis
  • [MeSH-minor] Adenoids / pathology. Appendix / pathology. Blotting, Western. Cell Line. Cell Line, Tumor. Choristoma / pathology. Clusterin / analysis. Gastric Mucosa / pathology. Gastritis / microbiology. Gastritis / pathology. Giant Lymph Node Hyperplasia / diagnosis. Giant Lymph Node Hyperplasia / pathology. Hashimoto Disease / pathology. Helicobacter Infections / pathology. Helicobacter pylori. Humans. Hyperplasia. Ileum / pathology. Immunohistochemistry. Intestinal Mucosa / pathology. Lymph Nodes / pathology. Lymphoid Tissue / pathology. Lymphoma, T-Cell / diagnosis. Lymphoma, T-Cell / pathology. Thyroid Gland / pathology. Up-Regulation

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  • (PMID = 20141577.001).
  • [ISSN] 1600-0714
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CLU protein, human; 0 / Clusterin; 0 / Tubulin
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9. Alsaad KO, Serra S, Perren A, Hsieh E, Chetty R: CK19 and CD99 immunoexpression profile in goblet cell (mucin-producing neuroendocrine tumors) and classical carcinoids of the vermiform appendix. Int J Surg Pathol; 2007 Jul;15(3):252-7
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  • [Title] CK19 and CD99 immunoexpression profile in goblet cell (mucin-producing neuroendocrine tumors) and classical carcinoids of the vermiform appendix.
  • The immunoexpression of CK19 recently has been identified as a marker of poor prognosis in pancreatic endocrine tumors and hepatocellular carcinoma.
  • The purpose of this study was to explore CK19 and CD99 immunostaining in mucin-producing neuroendocrine (goblet cell) and classical carcinoids of the appendix.
  • CK19/CD99 immunoexpression did not correlate with extent of tumor invasion and mesoappendiceal extension, mitotic activity, Ki-67 labeling index, presence of extracellular mucinous pools dissecting muscle, and angiolymphatic and perineural/neural invasion.
  • There is no difference in the immunostaining for CK19 and CD99 between GCCs and classic carcinoids, and both types of neuroendocrine tumor show the same extent of expression of both markers.
  • [MeSH-major] Antigens, CD / metabolism. Appendiceal Neoplasms / metabolism. Carcinoid Tumor / metabolism. Cell Adhesion Molecules / metabolism. Keratin-19 / metabolism
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Cell Proliferation. Gene Expression Regulation, Neoplastic. Humans. Neoplasm Invasiveness / pathology

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  • (PMID = 17652531.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Biomarkers, Tumor; 0 / CD99 protein, human; 0 / Cell Adhesion Molecules; 0 / Keratin-19
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10. Schon EA: Appendix 6. Changes in the mitochondrial transcriptome and proteome under various stresses and growth conditions. Methods Cell Biol; 2007;80:877-87
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  • [Title] Appendix 6. Changes in the mitochondrial transcriptome and proteome under various stresses and growth conditions.
  • [MeSH-minor] Animals. Bone Neoplasms / genetics. Bone Neoplasms / pathology. Breast Neoplasms / genetics. Breast Neoplasms / pathology. Caloric Restriction. Cold Temperature. Electron Transport Complex I / deficiency. Exercise / physiology. Gene Expression Regulation, Developmental. Gene Expression Regulation, Neoplastic. Humans. Osteosarcoma / genetics. Osteosarcoma / pathology. Tumor Cells, Cultured. Yeasts / genetics. Yeasts / growth & development. Yeasts / metabolism

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  • (PMID = 17445728.001).
  • [ISSN] 0091-679X
  • [Journal-full-title] Methods in cell biology
  • [ISO-abbreviation] Methods Cell Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Proteome; 0 / RNA, Messenger; 0 / mitochondrial messenger RNA; EC 1.6.5.3 / Electron Transport Complex I
  • [Number-of-references] 7
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11. Hatami M, Whitney K, Goldberg GL: Primary bilateral ovarian and uterine Burkitt's lymphoma following chemotherapy for breast cancer. Arch Gynecol Obstet; 2010 Apr;281(4):697-702
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  • A case of Burkitt's lymphoma involving the uterus, cervix, ovaries and appendix 15 years after adjuvant chemotherapy for breast cancer is presented.
  • Histologic sections of the uterus, cervix, ovaries, appendix and external iliac lymph node obtained at laparotomy revealed diffuse neoplastic lymphoid infiltration with necrosis.
  • After complete staging, chemotherapy was started and the patient is presently tumor free 41 months after the diagnosis.
  • Early diagnosis, aggressive chemotherapy, +/-surgical intervention, plays an important role in management and survival of patients with Burkitt's lymphoma.
  • [MeSH-major] Appendix / pathology. Breast Neoplasms / drug therapy. Burkitt Lymphoma / pathology. Carcinoma, Ductal, Breast / drug therapy. Neoplasms, Second Primary / pathology. Ovary / pathology. Uterus / pathology
  • [MeSH-minor] Female. Humans. Middle Aged. Neoplasms / pathology


12. Korkontzelos I, Papanicolaou S, Tsimoyiannis I, Kitsiou E, Stefos T, Tsanadis G, Antoniou N: Large carcinoid tumor of the appendix during pregnancy. Eur J Obstet Gynecol Reprod Biol; 2005 Feb 1;118(2):255-7
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  • [Title] Large carcinoid tumor of the appendix during pregnancy.
  • Diagnosis of acute appendicitis is considered more difficult in pregnant than in non-pregnant women.
  • The appendicial carcinoid tumor is a lesion that most frequently is discovered incidentally in the removed organ.
  • We report a rare case of an unruptured acute appendicitis during pregnancy, which proved to be a large carcinoid tumor.
  • [MeSH-major] Appendiceal Neoplasms / diagnosis. Carcinoid Tumor / diagnosis. Pregnancy Complications, Neoplastic


13. Rakovich G, Larue N: Mucocele of the appendix associated with a carcinoid of the terminal ileum. Can J Surg; 2007 Feb;50(1):66-7
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  • [Title] Mucocele of the appendix associated with a carcinoid of the terminal ileum.
  • [MeSH-major] Appendix / pathology. Carcinoid Tumor / complications. Cecal Diseases / complications. Ileal Neoplasms / complications. Mucocele / complications

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  • [Cites] Radiographics. 2003 May-Jun;23(3):645-62 [12740466.001]
  • [Cites] Br J Surg. 1995 Mar;82(3):299-306 [7795991.001]
  • [Cites] Cancer. 1973 Dec;32(6):1525-41 [4757938.001]
  • [Cites] Arch Surg. 2003 Jun;138(6):585-9; discussion 589-90 [12799327.001]
  • (PMID = 17391621.001).
  • [ISSN] 0008-428X
  • [Journal-full-title] Canadian journal of surgery. Journal canadien de chirurgie
  • [ISO-abbreviation] Can J Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC2384252
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14. Benedix F, Reimer A, Gastinger I, Mroczkowski P, Lippert H, Kube R, Study Group Colon/Rectum Carcinoma Primary Tumor: Primary appendiceal carcinoma--epidemiology, surgery and survival: results of a German multi-center study. Eur J Surg Oncol; 2010 Aug;36(8):763-71
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  • [Title] Primary appendiceal carcinoma--epidemiology, surgery and survival: results of a German multi-center study.
  • BACKGROUND: While carcinoma of the colon is a common malignancy, primary carcinoma of the appendix is rare.
  • Many retrospective reviews outlined experience from different centers on appendiceal neoplasms.
  • The aim of this study was to analyze the type of surgery and survival of patients with appendiceal malignancies using data from a German multi-center observational study (31 341 patients).
  • METHODS: During a five-year period, 196 consecutive patients with malignant appendiceal tumors were distributed into four groups: appendiceal carcinoids, adenocarcinoma, mucinous adenocarcinoma and adenosquamous carcinoma.
  • Mean age at presentation was youngest for carcinoid tumors.
  • Carcinoid tumors had lowest tumor size and localized disease was present in 72.9%.
  • Overall 5-year survival was 83.1% for carcinoid vs. 49.2% for non-carcinoid tumors.
  • Histological subtype and tumor stage significantly affected survival.
  • CONCLUSIONS: Long-term outcome of carcinoid tumors is superior to non-carcinoid neoplasms.
  • Among all appendiceal neoplasms, adenosquamous carcinoma is the rarest histological subtype which is most commonly associated with advanced tumor stage and worst prognosis.
  • However, the high rate of right hemicolectomy in patients with small carcinoid tumors needs to be critically discussed.
  • [MeSH-major] Appendiceal Neoplasms / epidemiology. Appendiceal Neoplasms / surgery. Colectomy
  • [MeSH-minor] Adenocarcinoma / epidemiology. Adenocarcinoma / surgery. Adenocarcinoma, Mucinous / epidemiology. Adenocarcinoma, Mucinous / surgery. Adult. Aged. Appendicitis / diagnosis. Carcinoid Tumor / epidemiology. Carcinoid Tumor / surgery. Carcinoma, Adenosquamous / epidemiology. Carcinoma, Adenosquamous / surgery. Diagnosis, Differential. Female. Germany. Humans. Male. Middle Aged. Neoplasm Staging. Unnecessary Procedures / statistics & numerical data

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  • [Copyright] Copyright (c) 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20561765.001).
  • [ISSN] 1532-2157
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] England
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15. Gidwani AL, Blake G: Four pathologies in one. Ir J Med Sci; 2008 Mar;177(1):77-8
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  • Incidental findings as Meckel's diverticulum or Crohn's disease during this operation are not uncommon.
  • METHODS: Laparotomy revealed a perforated appendix with an incidental Meckel's diverticulum and thickened distal small bowel with fat encroaching the mesentery suggestive of active Crohn's disease.
  • A routine appendicectomy was done and pathology revealed inflamed perforated appendix with an incidental carcinoid within the appendix.
  • CONCLUSIONS: Presence of active Crohn's disease along with an incidental Meckel's diverticulum or acute appendicitis raises controversies in their surgical management.
  • [MeSH-major] Appendiceal Neoplasms / complications. Appendicitis / complications. Carcinoid Tumor / complications. Colitis, Ulcerative / complications. Meckel Diverticulum / complications

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  • [Cites] J Chir (Paris). 1985 May;122(5):311-4 [4044690.001]
  • [Cites] Chirurg. 1989 Aug;60(8):549-52 [2791743.001]
  • [Cites] Am Surg. 1991 May;57(5):282-5 [2039123.001]
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  • [Cites] Vestn Khir Im I I Grek. 1990 Jul;145(7):48 [2176392.001]
  • (PMID = 17628741.001).
  • [ISSN] 1863-4362
  • [Journal-full-title] Irish journal of medical science
  • [ISO-abbreviation] Ir J Med Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Ireland
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16. Uchikov A, Genova S, Peshev Zh, Dimov R, Dimitrov I, Murdzhev K: [Carcinoid tumors of the gastrointestinal tract--frequency, organ localization, clinical course, treatment (a presentation of 10 cases)]. Khirurgiia (Sofiia); 2005;(4-5):20-2
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  • [Title] [Carcinoid tumors of the gastrointestinal tract--frequency, organ localization, clinical course, treatment (a presentation of 10 cases)].
  • Carcinoid tumors originate from the argentofile cells found at the bottom of the crypt of Lieberkuhn.
  • In spite of their slow growth and comparatively better prognosis, the carcinoid are malignant tumors, which effective treatment is their surgical resection.
  • We present 10 patients with carcinoid of the gastrointestinal tract (GIT)--3 from small intestine, 3 from large intestine, 2 from appendix, I from rectum and 1 from stomach, operated at our clinic for a 6 year period of time.
  • [MeSH-major] Carcinoid Tumor. Gastrointestinal Neoplasms
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Disease-Free Survival. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Metastasis

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  • (PMID = 18693512.001).
  • [ISSN] 0450-2167
  • [Journal-full-title] Khirurgii︠a︡
  • [ISO-abbreviation] Khirurgiia (Sofiia)
  • [Language] bul
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Bulgaria
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17. Maes M, Segers K, Cheyns P: Goblet cell carcinoid of the appendix: laparoscopic appendectomy or right hemicolectomy? Acta Chir Belg; 2008 Jul-Aug;108(4):447-50
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  • [Title] Goblet cell carcinoid of the appendix: laparoscopic appendectomy or right hemicolectomy?
  • Goblet cell carcinoids are uncommon tumours with histological features of both adenocarcinoma and carcinoid tumour.
  • They occur predominantly in the appendix and although the malignant potential remains unclear, adenocarcinoids appear to be more aggressive than conventional carcinoids.
  • Macroscopically, a diffusely inflamed appendix was found with no sign of perforation.
  • Histopathological examination revealed a goblet cell carcinoid with characteristics of aggressive behaviour, indicating the need for laparoscopic right hemicolectomy in which, however, neither residual tumour nor metastatic lymph nodes could be found.
  • As they may present the same clinical presentation, pathological diagnosis is required to distinguish goblet cell carcinoid from acute appendicitis.
  • Two-stage surgery for goblet cell carcinoid is advocated in the literature, but the debate still continues as to whether the goblet cell carcinoid should be treated by appendectomy alone, as for most carcinoids, or by right hemicolectomy, as for the appendiceal adenocarcinoma.
  • [MeSH-major] Appendectomy / methods. Appendiceal Neoplasms / surgery. Carcinoid Tumor / surgery. Colectomy / methods. Laparoscopy / methods
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Follow-Up Studies. Humans

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  • (PMID = 18807600.001).
  • [ISSN] 0001-5458
  • [Journal-full-title] Acta chirurgica Belgica
  • [ISO-abbreviation] Acta Chir. Belg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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18. Kuester D, Dalicho S, Mönkemüller K, Benedix F, Lippert H, Guenther T, Roessner A, Meyer F: Synchronous multifocal colorectal carcinoma in a patient with delayed diagnosis of ulcerative pancolitis. Pathol Res Pract; 2008;204(12):905-10
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  • [Title] Synchronous multifocal colorectal carcinoma in a patient with delayed diagnosis of ulcerative pancolitis.
  • Relatively often, the patients present with multiple synchronous or metachronous tumors.
  • Regardless of the diagnosis and medical advice, the patient initially refused therapy, and proctocolectomy was delayed for 12 months.
  • At the time of colectomy, advanced tumor stage was diagnosed and classified as pT3c(4) pN1(2/120) M0 V1 R0, UICC stage IIIB, G2.
  • Furthermore, a mucinous cystadenoma was found in the appendix in the setting of ulcerative colitis.
  • [MeSH-major] Adenocarcinoma / pathology. Colitis, Ulcerative / complications. Colitis, Ulcerative / pathology. Colorectal Neoplasms / pathology
  • [MeSH-minor] Adult. Appendiceal Neoplasms / pathology. Cystadenoma, Mucinous / pathology. Humans. Male. Neoplasm Staging. Neoplasms, Multiple Primary / pathology

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  • [CommentIn] Zentralbl Chir. 2015 Dec;140(6):624-6 [25076166.001]
  • (PMID = 18842350.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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19. Chen TH, Lin CJ, Wu RC, Ho YP, Hsu CM, Lin WP, Tseng YP, Chen CH, Chiu CT: The application of miniprobe ultrasonography in the diagnosis of colorectal subepithelial lesions. Chang Gung Med J; 2010 Jul-Aug;33(4):380-8
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  • [Title] The application of miniprobe ultrasonography in the diagnosis of colorectal subepithelial lesions.
  • This study investigated the value of colonoscopic miniprobe ultrasonography for differential diagnosis and treatment strategy in patients with colorectal subepithelial lesions (SEL).
  • The final diagnosis of these lesions was confirmed by cross section imaging, histopathologic findings, or clinical follow-up.
  • Thirteen patients, suspected of having rectal carcinoid tumors (mean size, 6.9 +/- 3.3 mm), were treated radically by endoscopic mucosal resection using a transparent cap (EMRC) after EUS confirmation of no muscular invasion.
  • Three patients had no residual or recurrent carcinoid tumor on EUS examination after previous empiric polypectomy or biopsy.
  • Five patients had suspected rectal myogenic stromal tumors on EUS; three were transferred for surgical resection due to uterine myoma compression (N = 2) or mucinous adenocarcinoma of the appendix with rectal metastasis (N = 1), and two had uterine myoma detected by gynecologic ultrasound or CT.
  • One appendiceal stone with orifice obstruction mimicking cecal submucosal tumor was proved by surgical resection.
  • [MeSH-major] Colonoscopy / methods. Colorectal Neoplasms / ultrasonography. Endosonography / methods

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  • (PMID = 20804667.001).
  • [ISSN] 2309-835X
  • [Journal-full-title] Chang Gung medical journal
  • [ISO-abbreviation] Chang Gung Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China (Republic : 1949- )
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20. Tran TA, Holloway RW, Finkler NJ: Metastatic appendiceal mucinous adenocarcinoma to well-differentiated diffuse mesothelioma of the peritoneal cavity: a mimicker of florid mesothelial hyperplasia in association with neoplasms. Int J Gynecol Pathol; 2008 Oct;27(4):526-30
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  • [Title] Metastatic appendiceal mucinous adenocarcinoma to well-differentiated diffuse mesothelioma of the peritoneal cavity: a mimicker of florid mesothelial hyperplasia in association with neoplasms.
  • Atypical/florid mesothelial hyperplasia associated with another neoplastic process is not an infrequent phenomenon and has been reported in a variety of tumors.
  • The subsequent operation, however, demonstrated a mucinous neoplasm of the appendix with involvement of the peritoneal cavity in the form of peritoneal mucinous carcinomatosis as well as metastases to the uterine serosa and adnexal surfaces.
  • Microscopic analysis revealed an appendiceal adenocarcinoma with signet-ring-cell features that has metastasized to a diffuse well-differentiated mesothelioma of the peritoneal cavity.
  • To the best of our knowledge, this is the first report of a metastatic appendiceal mucinous adenocarcinoma to a well-differentiated diffuse mesothelioma of the peritoneal cavity.
  • This unusual case report expands the spectrum of mesothelial proliferation in conjunction with a malignant neoplasm and serves to remind pathologists that such a concomitant occurrence exists.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Appendiceal Neoplasms / pathology. Mesothelioma / pathology. Peritoneal Neoplasms / secondary
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Histocytochemistry. Humans

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  • (PMID = 18753969.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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21. Nezhat C, Datta MS, Defazio A, Nezhat F, Nezhat C: Natural orifice-assisted laparoscopic appendectomy. JSLS; 2009 Jan-Mar;13(1):14-8
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  • METHODS: We reviewed cases of 42 patients who underwent total laparoscopic hysterectomy or laparoscopic-assisted vaginal hysterectomy followed by appendectomy, performed by applying a stapler and removing the appendix transvaginally.
  • By using a small-diameter laparoscope, the appendix was mobilized, especially in patients with adhesions, endometriosis, or retrocecal appendix, to facilitate transvaginal access with the stapler.
  • Appendiceal pathology included serosal adhesions (14), fibrous obliteration of the lumen (12), endometriosis (4), serositis (2), and carcinoid tumor (1), among others.

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  • (PMID = 19366534.001).
  • [ISSN] 1086-8089
  • [Journal-full-title] JSLS : Journal of the Society of Laparoendoscopic Surgeons
  • [ISO-abbreviation] JSLS
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3015901
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22. Thirunavukarasu P, Sathaiah M, Singla S, Sukumar S, Karunamurthy A, Pragatheeshwar KD, Lee KK, Zeh H 3rd, Kane KM, Bartlett DL: Medullary carcinoma of the large intestine: a population based analysis. Int J Oncol; 2010 Oct;37(4):901-7
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  • To date, there has been no epidemiological study of this rare tumor type, which has now been incorporated as a separate entity in the World Health Organization (WHO) classification of colorectal cancers.
  • We observed that MCs were rare tumors, constituting approximately 5-8 cases for every 10,000 colon cancers diagnosed, with a mean annual incidence of 3.47 (+/-0.75) per 10 million population.
  • Mean age at diagnosis was 69.3 (+/-12.5) years, with incidence increasing with age.
  • There were no cases reliably identified in the rectum or appendix.
  • MCs commonly presented with Stage II disease, with 10% presenting with metastases.
  • Only one patient presented with N2b disease (>7 positive nodes).
  • [MeSH-major] Adenocarcinoma / epidemiology. Carcinoma, Medullary / epidemiology. Colorectal Neoplasms / epidemiology
  • [MeSH-minor] Age Distribution. Age Factors. Aged. Aged, 80 and over. Carcinoembryonic Antigen / blood. Cell Differentiation. Ethnic Groups. Female. Humans. Incidence. Kaplan-Meier Estimate. Male. Middle Aged. Neoplasm Staging. Neoplasms, Multiple Primary / epidemiology. Prognosis. SEER Program. Sex Distribution. Sex Factors. Survival Rate. Time Factors. United States

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  • (PMID = 20811712.001).
  • [ISSN] 1791-2423
  • [Journal-full-title] International journal of oncology
  • [ISO-abbreviation] Int. J. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / T32 CA113263
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen
  • [Other-IDs] NLM/ NIHMS609288; NLM/ PMC4127912
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23. Kianmanesh R, O'toole D, Sauvanet A, Ruszniewski P, Belghiti J: [Surgical treatment of gastric, enteric, and pancreatic endocrine tumors Part 1. Treatment of primary endocrine tumors]. J Chir (Paris); 2005 May-Jun;142(3):132-49
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  • [Title] [Surgical treatment of gastric, enteric, and pancreatic endocrine tumors Part 1. Treatment of primary endocrine tumors].
  • [Transliterated title] Traitement chirurgical des tumeurs endocrines gastro-entéro-pancréatiques.
  • Endocrine tumors (ET) of the digestive tract (formerly called neuroendocrine tumors) are rare.
  • They are classified into two principal types: gastrointestinal ET's (formerly called carcinoid tumors) which are the most common, and pancreaticoduodenal ET's.
  • The surgical goals are to: 1. prolong survival by resecting the primary tumor and any nodal or hepatic metastases, 2. control the symptoms related to hormonal secretion, 3. prevent or treat local complications.
  • The most common sites of gastrointestinal ET's ( carcinoids) are the appendix and the rectum; these are often small (<1 cm), benign, and discovered fortuitously at the time of appendectomy or colonoscopic removal.
  • They are usually malignant and of advanced stage at diagnosis presenting as a palpable or obstructing mass or as liver metastases.
  • Insulinoma and gastrinoma (cause of the Zollinger-Ellison syndrome) are the most common functional ET's. 80% are sporadic; in these cases, tumor size, location, and malignant potential determine the type of resection which may vary from a simple enucleation to a formal pancreatectomy.
  • In 10-20% of cases, pancreaticoduodenal ET presents in the setting of multiple endocrine neoplasia (NEM type I), an autosomal-dominant genetic disease with multifocal endocrine involvement of the pituitary, parathyroid, pancreas, and adrenal glands.
  • For gastrinoma with NEM-I, the benefit of surgical resection for tumors less than 2-3 cm in size is not clear.
  • But the eventual development of liver metastases which are the most common cause of mortality still argues for an aggressive surgical approach in the early stages of the disease.
  • [MeSH-major] Carcinoid Tumor / surgery. Carcinoma, Islet Cell / surgery. Carcinoma, Neuroendocrine / surgery. Insulinoma / surgery. Intestinal Neoplasms / surgery. Multiple Endocrine Neoplasia Type 1 / surgery. Pancreatic Neoplasms / surgery. Stomach Neoplasms / surgery. Zollinger-Ellison Syndrome / surgery
  • [MeSH-minor] Adult. Gastrinoma / diagnosis. Gastrinoma / surgery. Glucagonoma / diagnosis. Glucagonoma / surgery. Humans. Liver Neoplasms / secondary. Lymphatic Metastasis. Malignant Carcinoid Syndrome / diagnosis. Malignant Carcinoid Syndrome / surgery. Multicenter Studies as Topic. Pancreatectomy. Postoperative Care. Postoperative Complications. Prognosis. Somatostatinoma / diagnosis. Somatostatinoma / surgery. Vipoma / diagnosis. Vipoma / surgery

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  • (PMID = 16142076.001).
  • [ISSN] 0021-7697
  • [Journal-full-title] Journal de chirurgie
  • [ISO-abbreviation] J Chir (Paris)
  • [Language] fre
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 236
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24. Rossi G, Nannini N, Bertolini F, Mengoli MC, Fano R, Cavazza A: Clear cell carcinoid of the appendix: an uncommon variant of lipid-rich neuroendocrine tumor with a broad differential diagnosis. Endocr Pathol; 2010 Dec;21(4):258-62
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  • [Title] Clear cell carcinoid of the appendix: an uncommon variant of lipid-rich neuroendocrine tumor with a broad differential diagnosis.
  • The designation of clear cell/lipid-rich refers to an unusual variant of neuroendocrine tumor ("carcinoid") described in several organs, but only recently observed in the appendix.
  • In this study, we report the morphologic, immunohistochemical, and ultrastructural features of an incidentally discovered appendiceal clear cell/lipid-rich carcinoid in a 32-year-old man without any evidence of von Hippel-Lindau disease.
  • Differential diagnosis with mimicking neoplastic and non-tumor lesions, epidemiology, and clinical behavior of this exceedingly rare variant of carcinoid of the appendix are also discussed.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Carcinoid Tumor / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Diagnosis, Differential. Humans. Immunohistochemistry. Male. Microscopy, Electron, Transmission

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  • (PMID = 20814762.001).
  • [ISSN] 1559-0097
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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25. Dietrich CS 3rd, Desimone CP, Modesitt SC, Depriest PD, Ueland FR, Pavlik EJ, Kryscio R, Cibull M, Huh W, Partridge E, Numnum TM, Schilder J, Higgins RV, van Nagell JR 2nd: Primary appendiceal cancer: gynecologic manifestations and treatment options. Gynecol Oncol; 2007 Mar;104(3):602-6
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  • [Title] Primary appendiceal cancer: gynecologic manifestations and treatment options.
  • OBJECTIVE: To determine the presenting symptoms, gynecologic manifestations, and optimal intraoperative management of women with primary appendiceal cancer.
  • METHODS: A multi-institutional investigation was performed to identify female patients with primary appendiceal cancer who were treated from 1990 to present.
  • RESULTS: Forty-eight women with primary appendiceal cancer were identified from the tumor registries of participating institutions.
  • Ovarian involvement by metastatic appendiceal cancer was documented in 18 patients (38%).
  • Forty-one patients (85%) presented with advanced stage appendiceal cancer (Stage III or IV) and 19 patients (46%) received postoperative chemotherapy, most commonly with a combination of 5-FU/Leukovorin.
  • Following surgery, 22 patients (46%) experienced disease progression or recurrence, and 14 have died of disease.
  • CONCLUSION: Women with primary appendiceal cancer frequently present with ovarian metastases, and initial surgical intervention is often performed by a gynecologic oncologist.
  • The appendix should be examined intraoperatively, and if appendiceal carcinoma is identified, a right hemicolectomy and appropriate surgical staging should be considered.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Appendiceal Neoplasms / surgery. Ovarian Neoplasms / secondary. Ovarian Neoplasms / surgery

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  • [CommentIn] Gynecol Oncol. 2007 Dec;107(3):592; author reply 592-3 [17765296.001]
  • (PMID = 17055559.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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26. Wang GL, Wang MY, Wei WB: [Clinical features and treatment of choroidal metastasis]. Zhonghua Yan Ke Za Zhi; 2009 Mar;45(3):229-33
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  • Primary tumours were found in 40 cases (81.6%) (surgical excision in 25 cases), consisting of breast carcinoma in 16 cases (32.7%), lung carcinoma in 14 cases (28.6%), hepatoma and cholangiocarcinoma in 3 cases, colon and stomach carcinomas in 3 cases, gynecologic appendix carcinoma (including 1 case of ovarian mucous cyst adenocarcinoma) in 2 cases, nasopharyngeal adenocarcinoma in 1 case, vertebra tumor in 1 case, undetected in 5 cases (10.2%) and under detection in 4 cases (8.2%).
  • The tumor became flattened and vision remained stable at 3 months after plaque radiotherapy in 1 case.
  • The classification of metastatic lesions into solitary, diffuse and early types is helpful for the evaluation of the disease process.
  • The primary tumor can be found in 80% of cases.
  • These two cancers account for 75% of primary tumors.
  • [MeSH-major] Choroid Neoplasms / secondary. Choroid Neoplasms / therapy
  • [MeSH-minor] Adult. Aged. Female. Fluorescein Angiography. Fundus Oculi. Humans. Male. Middle Aged. Neoplasm Metastasis. Retrospective Studies. Treatment Outcome. Young Adult

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  • (PMID = 19575917.001).
  • [ISSN] 0412-4081
  • [Journal-full-title] [Zhonghua yan ke za zhi] Chinese journal of ophthalmology
  • [ISO-abbreviation] Zhonghua Yan Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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27. Dall'Igna P, Ferrari A, Luzzatto C, Bisogno G, Casanova M, Alaggio R, Terenziani M, Cecchetto G: Carcinoid tumor of the appendix in childhood: the experience of two Italian institutions. J Pediatr Gastroenterol Nutr; 2005 Feb;40(2):216-9
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  • [Title] Carcinoid tumor of the appendix in childhood: the experience of two Italian institutions.
  • OBJECTIVES: Although rare, carcinoid tumor of the appendix is the most common neoplasm of the gastrointestinal tract in children and adolescents.
  • It is usually an incidental finding after a laparotomy for appendectomy, with a frequency of 2 to 5 cases per 1000 appendectomies.
  • The experience with 14 cases of carcinoid reported in the appendix is described.
  • METHODS AND RESULTS: In six patients the tumor measured 1 cm or less; only in one patient did it measure 2 cm.
  • In three patients the tumor measured between 1 and 2 cm and in four the size was not known.
  • All tumors were discovered by chance, and three patients underwent further surgery as a result of suspected involvement of the margins.
  • All the patients were alive with no evidence of disease at 24 to 214 months from diagnosis.
  • In our experience, both patients with local invasiveness and the patient with a tumor larger than 2 cm had good outcomes.
  • Ileocolectomy performed in the patient with a 2-cm tumor and in another two patients with smaller tumors did not demonstrate residual disease.
  • Although the need for right hemicolectomy still remains controversial for tumors measuring more than 2 cm, the approach may be nonaggressive in case of tumors invading the serosa and the periappendiceal fat.
  • Nonaggressive treatment has been suggested by some authors in cases of tumors larger than 2 cm; however, larger series need to be evaluated.
  • [MeSH-major] Appendectomy. Appendiceal Neoplasms / diagnosis. Carcinoid Tumor / diagnosis
  • [MeSH-minor] Adolescent. Child. Colectomy / methods. Female. Humans. Ileus / surgery. Male. Neoplasm Invasiveness. Neoplasm Recurrence, Local / epidemiology. Prognosis. Treatment Outcome


28. Kwak JW, Paik CN, Jung SH, Chang UI, Lee KM, Chung WC, Yoo JY, Yang JM: An inflammatory myofibroblastic tumor of the ampulla of vater successfully managed with endoscopic papillectomy: report of a case. Gut Liver; 2010 Sep;4(3):419-22
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  • [Title] An inflammatory myofibroblastic tumor of the ampulla of vater successfully managed with endoscopic papillectomy: report of a case.
  • Inflammatory myofibroblastic tumors (IMTs) are solid neoplastic mesenchymal proliferations composed of myofibroblastic spindle cells admixed with inflammatory infiltrates.
  • The documented sites in the gastrointestinal tract include the esophagus, small intestine, colon, appendix, rectum, pancreas, spleen, liver, and Meckel's diverticulum.

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  • (PMID = 20981226.001).
  • [ISSN] 2005-1212
  • [Journal-full-title] Gut and liver
  • [ISO-abbreviation] Gut Liver
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2956361
  • [Keywords] NOTNLM ; Ampulla of Vater / Endoscopic papillectomy / Inflammatory myofibroblastic tumor
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29. Rahimi K, Gologan A, Haliotis T, Lamoureux E, Chetty R: Gastrointestinal stromal tumor with autonomic nerve differentiation and coexistent mantle cell lymphoma involving the appendix. Int J Clin Exp Pathol; 2009;2(6):608-13
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  • [Title] Gastrointestinal stromal tumor with autonomic nerve differentiation and coexistent mantle cell lymphoma involving the appendix.
  • Gastrointestinal stromal tumor (GIST) and mantle cell lymphoma involving the appendix are rare as individual disease entities.
  • We describe a 65-year old female who presented with extensive ileocecal mantle cell lymphoma, which extended to the appendix.
  • The appendix was involved by mantle cell lymphoma and an incidental coexistent GIST was noted in the appendiceal wall.
  • This is the first description of the association of a GIST with autonomic nerve differentiation coexisting with mantle cell lymphoma in the appendix.

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  • (PMID = 19636397.001).
  • [ISSN] 1936-2625
  • [Journal-full-title] International journal of clinical and experimental pathology
  • [ISO-abbreviation] Int J Clin Exp Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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30. Nonaka D, Kusamura S, Baratti D, Casali P, Younan R, Deraco M: CDX-2 expression in pseudomyxoma peritonei: a clinicopathological study of 42 cases. Histopathology; 2006 Oct;49(4):381-7
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  • The appendix evaluated in 25 cases showed two mucinous adenocarcinomas and 21 low-grade appendiceal mucinous neoplasms.
  • This is a useful marker to confirm an appendiceal origin of PMP, particularly when used in conjunction with CK7, CK20, MUC-2 and MUC-5AC.
  • [MeSH-major] Appendiceal Neoplasms / metabolism. Biomarkers, Tumor / analysis. Homeodomain Proteins / metabolism. Peritoneal Neoplasms / metabolism. Pseudomyxoma Peritonei / metabolism. Trans-Activators / metabolism
  • [MeSH-minor] Adult. Aged. Carcinoid Tumor / pathology. Disease-Free Survival. Female. Humans. Immunohistochemistry. Keratin-20. Keratin-7. Keratins / metabolism. Male. Middle Aged. Mucin 5AC. Mucin-2. Mucins / metabolism. Neoplasms, Multiple Primary / metabolism. Neoplasms, Multiple Primary / pathology. Prognosis. Retrospective Studies. Survival Analysis

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  • (PMID = 16978201.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Homeodomain Proteins; 0 / KRT20 protein, human; 0 / KRT7 protein, human; 0 / Keratin-20; 0 / Keratin-7; 0 / MUC2 protein, human; 0 / MUC5AC protein, human; 0 / Mucin 5AC; 0 / Mucin-2; 0 / Mucins; 0 / Trans-Activators; 156560-97-3 / Cdx-2-3 protein; 68238-35-7 / Keratins
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31. Buntrock M, Manncke K: [Free mobile intra-abdominal "tumor"]. Chirurg; 2010 Feb;81(2):148-50
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  • [Title] [Free mobile intra-abdominal "tumor"].
  • [Transliterated title] Frei beweglicher "Tumor" im Abdomen.
  • The rare condition of an accidentally discovered 3 cm sized tumor in the abdomen is reported which was completely free and migrating within the abdominal cavity.
  • Surprisingly the tumor was localized at different sites.
  • Histopathology revealed that it was most probably a calcified appendix epiploicum separated from the colon.
  • [MeSH-major] Abdominal Neoplasms / diagnosis. Abdominal Neoplasms / surgery. Colon
  • [MeSH-minor] Diagnosis, Differential. Humans. Laparoscopy. Male. Middle Aged. Patient Care Team. Tomography, X-Ray Computed. Ultrasonography

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  • (PMID = 19760376.001).
  • [ISSN] 1433-0385
  • [Journal-full-title] Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen
  • [ISO-abbreviation] Chirurg
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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32. Feltmate CM, Lee KR, Johnson M, Schorge JO, Wong KK, Hao K, Welch WR, Bell DA, Berkowitz RS, Mok SC: Whole-genome allelotyping identified distinct loss-of-heterozygosity patterns in mucinous ovarian and appendiceal carcinomas. Clin Cancer Res; 2005 Nov 1;11(21):7651-7
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  • [Title] Whole-genome allelotyping identified distinct loss-of-heterozygosity patterns in mucinous ovarian and appendiceal carcinomas.
  • In addition, the differential diagnosis of metastatic mucinous carcinomas to the ovaries, particularly those originating from the appendix, remains challenging.
  • The purpose of this study is to identify molecular biomarkers for mucinous ovarian adenocarcinoma and compare them with those of appendiceal origin.
  • EXPERIMENTAL DESIGN: Genome-wide loss-of-heterozygosity (LOH) analysis was done on DNA isolated from 28 microdissected primary mucinous ovarian carcinomas and five appendiceal adenocarcinomas.
  • Markers from high-loss regions were selected for further analysis on a total of 32 ovarian and 14 appendiceal cancers.
  • The frequency of allelic loss was similar between high-grade and low-grade mucinous ovarian carcinoma cases but was significantly higher in ovarian versus appendiceal cases.
  • In addition, LOH rates on five chromosomal loci were statistically different between ovarian and appendiceal carcinomas.
  • Despite histologic similarities between mucinous ovarian carcinomas and metastatic appendiceal carcinomas, they have distinct LOH profiles, which may be used for distinguishing the two diseases.
  • [MeSH-major] Adenocarcinoma, Mucinous / genetics. Appendiceal Neoplasms / genetics. Appendiceal Neoplasms / pathology. Carcinoma / genetics. Genome. Genotype. Heterozygote. Loss of Heterozygosity. Ovarian Neoplasms / genetics. Ovarian Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Alleles. Biomarkers, Tumor. Female. Genetic Techniques. Genome, Human. Humans. Male. Middle Aged

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  • (PMID = 16278384.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P50CA165009; United States / NCRR NIH HHS / RR / RR33CA103595
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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33. Onda M, Beers R, Xiang L, Nagata S, Wang QC, Pastan I: An immunotoxin with greatly reduced immunogenicity by identification and removal of B cell epitopes. Proc Natl Acad Sci U S A; 2008 Aug 12;105(32):11311-6
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  • Recombinant immunotoxins are hybrid proteins composed of an Fv that binds to a tumor antigen fused to a bacterial or plant toxin.
  • In marked contrast, only minor responses have been observed in trials with immunotoxins targeting solid tumors, because only a single treatment cycle can be given before antibodies develop.
  • The new immunotoxin (HA22-8X) is significantly less immunogenic in three strains of mice, yet retains full cytotoxic and anti-tumor activities.

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  • (PMID = 18678888.001).
  • [ISSN] 1091-6490
  • [Journal-full-title] Proceedings of the National Academy of Sciences of the United States of America
  • [ISO-abbreviation] Proc. Natl. Acad. Sci. U.S.A.
  • [Language] ENG
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies; 0 / Bacterial Toxins; 0 / Enterotoxins; 0 / Epitopes, B-Lymphocyte; 0 / Exotoxins; 0 / RFB4(dsFv)-PE38 recombinant immunotoxin; 0 / Recombinant Fusion Proteins; 0 / Virulence Factors; EC 2.4.2.- / ADP Ribose Transferases; EC 2.4.2.31 / toxA protein, Pseudomonas aeruginosa
  • [Other-IDs] NLM/ PMC2516223
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34. Waisberg DR, Fava AS, Martins LC, Matos LL, Franco MI, Waisberg J: Colonic carcinoid tumors: a clinicopathologic study of 23 patients from a single institution. Arq Gastroenterol; 2009 Oct-Dec;46(4):288-93
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  • [Title] Colonic carcinoid tumors: a clinicopathologic study of 23 patients from a single institution.
  • CONTEXT: Colonic carcinoids, excluding those arising in the appendix, have proved to be extremely rare.
  • OBJECTIVE: To review the clinicopathologic features of patients operated on carcinoid tumors of the colon.
  • The clinical and histopathological data of patients who were pathologically diagnosed as having carcinoid tumors and submitted to surgical treatment over a 30-year period (1977-2007) were gathered.
  • Spreading of the disease to the liver and peritoneum was found in two (8.7%) patients who submitted to intestinal bypass.
  • In the resected cases, the lymph nodes were compromised in 10 patients (47.6%) and disease-free in 11 (52.4%).
  • The tumors had penetrated the muscularis propria in all resected cases.
  • Four (17.4%) patients had a second non-carcinoid primary tumor.
  • Fifteen patients (65.2%) remain alive without evidence of active disease.
  • CONCLUSIONS: Carcinoid tumors of the colon are frequently right-sided and may be clinically occult until an advanced stage is reached.
  • Based on the relatively poor survival rates reported, it is recommended that, in addition to standard surgical resection, vigorous surveillance for metastatic disease must be performed, particularly during the first 2 years after surgery.
  • In addition, these patients require evaluation of the entire gastrointestinal tract for evidence of coexisting malignancy, along with an extended period of follow-up, because tumor recurrences after 5 years are not uncommon.
  • [MeSH-major] Carcinoid Tumor / pathology. Colonic Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Metastasis. Neoplasm Recurrence, Local

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  • (PMID = 20232008.001).
  • [ISSN] 1678-4219
  • [Journal-full-title] Arquivos de gastroenterologia
  • [ISO-abbreviation] Arq Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Brazil
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35. Behranwala KA, Agarwal T, El-Sharkawi D, Shorvon D, Chang A: Laparoscopic resection of mucinous cystadenoma of appendix: a careful decision. Surg Laparosc Endosc Percutan Tech; 2006 Oct;16(5):347-8
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  • [Title] Laparoscopic resection of mucinous cystadenoma of appendix: a careful decision.
  • Appendiceal mucoceles are mainly due to cystadenoma or cystadenocarcinoma.
  • Definite diagnosis is difficult preoperatively and is usually peroperatively.
  • We present a case to highlight this point and especially deplore the use of laparoscopy if the tumor clearly extends beyond the appendix.
  • [MeSH-major] Appendiceal Neoplasms / surgery. Cystadenoma, Mucinous / surgery. Digestive System Surgical Procedures / methods

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  • (PMID = 17057579.001).
  • [ISSN] 1530-4515
  • [Journal-full-title] Surgical laparoscopy, endoscopy & percutaneous techniques
  • [ISO-abbreviation] Surg Laparosc Endosc Percutan Tech
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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36. Lozano Sánchez FS, Muñoz Herrera A: [Surgical treatment of carotid paragangliomas]. Acta Otorrinolaringol Esp; 2009 Feb;60 Suppl 1:80-96
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  • [Transliterated title] Tratamiento quirúrgico de los paragangliomas carotídeos.
  • The second part analyzes special situations concerning carotid paraganglioma (unresectable, malignant, residual [persistent] or recurrent, bilateral and multiple tumors, associated diseases, tumors in children, etc.).
  • The final part of the article, in the form of an appendix, shows the characteristics and results of our series (30 carotid paragangliomas in 26 patients between 1994 and 2008).
  • [MeSH-major] Carotid Body Tumor / surgery

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  • (PMID = 19245779.001).
  • [ISSN] 0001-6519
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 57
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37. Abdalla MF, El-Hennawy HM: Unusual presentation for primary appendiceal lymphoma: A case report. Indian J Surg; 2010 Jul;72(Suppl 1):289-92
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  • [Title] Unusual presentation for primary appendiceal lymphoma: A case report.
  • Primary appendiceal neoplasms are uncommon, being found in approximately 0.5%-1.0% of appendectomy specimens at pathologic evaluation.
  • Primary appendiceal Burkitt's lymphomas are rare occurring in 0.015% of all gastrointestinal lymphomas.
  • Almost all reported cases of appendiceal lymphoma have proved to be non-Hodgkin lymphoma.
  • The majority of appendiceal lymphomas are of B-cell.
  • This report describes a rare case of primary appendiceal lymphoma in a patient presented with hematuria and dull aching right lower abdominal and back pain.

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  • (PMID = 23133274.001).
  • [ISSN] 0972-2068
  • [Journal-full-title] The Indian journal of surgery
  • [ISO-abbreviation] Indian J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3451848
  • [Keywords] NOTNLM ; Appendix / Burkitt’s / Lymphoma
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38. Miyazaki T, Ishiguro T, Ishibashi K, Itoyama S, Ishida H: Mucosa-associated lymphoid tissue lymphoma of the appendix vermiformis. Int Surg; 2010 Jan-Mar;95(1):27-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mucosa-associated lymphoid tissue lymphoma of the appendix vermiformis.
  • Computed tomography demonstrated right hydronephrosis and an irregular mass of 4 x 3 cm adjacent to the ileocecal region and iliopsoas muscle.
  • Laparotomy showed an appendiceal tumor invading the cecum, mesocolon, right ureter, and duodenum.
  • This is the sixth documented case of primary MALT lymphoma of the appendix.
  • The spectrum of sites in which gastrointestinal MALT lymphomas occur should be expanded to include the appendix.
  • [MeSH-major] Appendiceal Neoplasms / surgery. Lymphoma, B-Cell, Marginal Zone / surgery
  • [MeSH-minor] Antibodies, Monoclonal / blood. Antibodies, Monoclonal, Murine-Derived. Antigens, CD79 / blood. Female. Humans. Immunohistochemistry. Middle Aged. Neoplasm Invasiveness. Rituximab. Tomography, X-Ray Computed

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  • (PMID = 20480837.001).
  • [ISSN] 0020-8868
  • [Journal-full-title] International surgery
  • [ISO-abbreviation] Int Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antigens, CD79; 4F4X42SYQ6 / Rituximab
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39. Hernández-Ramírez DA, Portela-Rubio G, Suárez-Moreno RM, Salazar-Lozano CR, Madrazo-Navarro M: [Mucocele of the appendix: an unusual finding in a patient with ulcerative colitis]. Cir Cir; 2010 Jul-Aug;78(4):357-60
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  • [Title] [Mucocele of the appendix: an unusual finding in a patient with ulcerative colitis].
  • BACKGROUND: Patients with ulcerative colitis (UC) or Crohn's disease (CD) have an increased risk for the development of colorectal dysplasia and carcinoma.
  • Although appendiceal inflammation occurs histologically in 40-86% of colectomy specimens from patients with inflammatory bowel disease (IBD), appendiceal neoplasms have been reported only infrequently, and the notion of a direct association between IBD and appendiceal neoplasia is speculative.
  • Colonoscopy and biopsy established the diagnosis of UC (proctosigmoiditis).
  • Disease activity was moderate at the beginning and the patient initially received medical treatment with mesalazine and prednisone.
  • Final histological report revealed cystadenoma of the appendix.
  • CONCLUSIONS: We present the eighth patient, to our knowledge, with a primary cystadenoma of the appendix and UC.
  • [MeSH-major] Appendiceal Neoplasms / complications. Colitis, Ulcerative / complications. Cystadenoma / complications. Mucocele / etiology

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  • (PMID = 21167104.001).
  • [ISSN] 0009-7411
  • [Journal-full-title] Cirugía y cirujanos
  • [ISO-abbreviation] Cir Cir
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Mexico
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40. O'Brien GC, Nzewi E, Deasy J: Mucinous neoplasm of the appendix with elevated carcinoembryonic antigen. Ir Med J; 2005 Sep;98(8):240-1
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  • [Title] Mucinous neoplasm of the appendix with elevated carcinoembryonic antigen.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Appendiceal Neoplasms / pathology

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  • (PMID = 16255116.001).
  • [ISSN] 0332-3102
  • [Journal-full-title] Irish medical journal
  • [ISO-abbreviation] Ir Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen
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41. Peitsidis P, Papadimitriou C, Rodolakis A, Peitsidou A: Actinomycosis of the appendix and pelvis: a case report. J Reprod Med; 2008 Sep;53(9):711-3
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  • [Title] Actinomycosis of the appendix and pelvis: a case report.
  • Ultrasound and computed tomography were performed, revealing an ovarian tumor formation and acute appendicitis.
  • Diagnosis of actinomycosis was established with the presence of sulphur granules microscopically.
  • Inflammatory intestinal and pelvic disease can easily mislead the diagnosis, giving the impression of a neoplastic process.
  • [MeSH-major] Actinomycosis / diagnosis. Actinomycosis / surgery. Appendicitis / microbiology. Intrauterine Devices / adverse effects. Ovarian Diseases / microbiology


42. Bucher P, Gervaz P, Ris F, Oulhaci W, Egger JF, Morel P: Surgical treatment of appendiceal adenocarcinoid (goblet cell carcinoid). World J Surg; 2005 Nov;29(11):1436-9
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  • [Title] Surgical treatment of appendiceal adenocarcinoid (goblet cell carcinoid).
  • Adenocarcinoid of the appendix is an infrequent tumor with histologic features of both adenocarcinoma and carcinoid tumor.
  • The aim of this study was to analyze long-term results of surgical treatment for appendiceal adenocarcinoid.
  • A retrospective review (1991-2003) identified seven patients (median age 72, range 27-81 years) treated for appendiceal adenocarcinoid.
  • Indications for colectomy were tumor size (three cases) associated with appendectomy margin invasion in one case.
  • One patient with lymph node and peritoneal involvement experienced recurrence 9 months after hemicolectomy and died of the disease at 2 years.
  • Five patients were alive without disease at the time of the last follow-up.
  • Our results suggest that appendectomy alone could be used for appendiceal adenocarcinoid provided that the tumor (1) is less than 1 cm;.
  • (2) does not extend beyond the appendix adventitia;.
  • (3) has less than 2 mitoses/10 high power fields; and (4) has surgical margins that are tumor free.
  • The risk for developing colorectal adenocarcinoma seems to be extremely high in patients treated for appendiceal adenocarcinoid and warrants close follow-up with colonoscopic screening.
  • [MeSH-major] Appendectomy. Appendiceal Neoplasms / surgery. Carcinoid Tumor / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Colectomy. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Retrospective Studies

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  • (PMID = 16136284.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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43. Yong Jiang, Huawei Liu, Hu Long, Yingying Yang, Dianying Liao, Xiuhui Zhang: Goblet cell carcinoid of the appendix: a clinicopathological and immunohistochemical study of 26 cases from southwest china. Int J Surg Pathol; 2010 Dec;18(6):488-92
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  • [Title] Goblet cell carcinoid of the appendix: a clinicopathological and immunohistochemical study of 26 cases from southwest china.
  • Goblet cell carcinoid (GCC) of the appendix is characterized by a dual differentiation of both endocrine and gland.
  • Follow-up data showed that 1 patient died from peritoneal metastasis and that the other 17 cases survived free of the tumor.
  • [MeSH-major] Appendiceal Neoplasms / metabolism. Appendiceal Neoplasms / pathology. Carcinoid Tumor / metabolism. Carcinoid Tumor / pathology
  • [MeSH-minor] Adult. Aged. Animals. Biomarkers, Tumor / analysis. China. Female. Humans. Immunohistochemistry. Male. Middle Aged. Schistosomiasis / complications

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  • (PMID = 20732910.001).
  • [ISSN] 1940-2465
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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44. San Vicente B, Bardají C, Rigol S, Obiols P, Melo M, Bella R: [Retrospective evaluation of carcinoid tumors of the appendix in children]. Cir Pediatr; 2009 Apr;22(2):97-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Retrospective evaluation of carcinoid tumors of the appendix in children].
  • [Transliterated title] Estudio retrospectivo del tumor carcinoide apendicular en niños.
  • Carcinoids of the appendix are rare in children.
  • To investigate the significance of the diagnosis of appendiceal carcinoid tumors in children, we conducted a retrospective study in our institution.
  • In four patients the diagnosis was appendiceal carcinoid.
  • The median tumor diameter was lower than 1 cm and the appropriate treatment was appendectomy.
  • [MeSH-major] Appendix. Carcinoid Tumor. Cecal Neoplasms

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  • (PMID = 19715134.001).
  • [ISSN] 0214-1221
  • [Journal-full-title] Cirugía pediátrica : organo oficial de la Sociedad Española de Cirugía Pediátrica
  • [ISO-abbreviation] Cir Pediatr
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 14
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45. Huang WD, Feng DP, Xiao JR, Huang Q, Zheng W, Wu ZP, Zhou ZH, Yang XH, Xie N: [Surgical intervention and radiotherapy outcome of solitary plasmacytoma of cervical spine]. Zhonghua Wai Ke Za Zhi; 2010 May 1;48(9):697-701
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  • According to WBB staging system, surgical procedures were defined as total or subtotal resection (6 cases), appendix resection (4 cases), sagittal resection (3 cases) and total spondylectomy (8 cases).
  • Two cases without surgical treatment progressed to MM in 1 year and 1.5 years after confirmed diagnosis.
  • The other 15 patients had disease-free survival and after surgery and adjunctive radiotherapy.
  • Tumor excision with adjunctive radiotherapy can obviously reduce local recurrences and lower the possibility of progression to MM.
  • [MeSH-major] Cervical Vertebrae. Plasmacytoma / surgery. Spinal Neoplasms / surgery

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  • (PMID = 20646555.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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46. Terada T: Non-invasive Adenocarcinoma of the Vermiform Appendix: Incidence and Report of Four Cases among 512 Appendectomies. Gastroenterology Res; 2009 Aug;2(4):238-241
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  • [Title] Non-invasive Adenocarcinoma of the Vermiform Appendix: Incidence and Report of Four Cases among 512 Appendectomies.
  • : Tumors of the vermiform appendix are relatively rare.
  • More than 50% of appendiceal tumors are carcinoid tumors.
  • The author reviewed 512 consecutive pathological specimens of appendectomies in last ten years in our pathology laboratory in search for appendiceal tumors.
  • No other tumors including carcinoid tumors were recognized.
  • Pathologically, all the 4 tumors were non-invasive adenocarcinomas: 2 cases were flat type adenocarcinoma, 1 case was papillary adenocarcinoma, and 1 case was mucinous adenocarcinoma.
  • The results suggest that incidence of appendiceal adenocarcinoma was 0.8% of all appendectomies, and that non-invasive adenocarcinoma of the appendix shows variable morphologies, and that postoperative clinical outcome of non-invasive appendiceal tumor is good.

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  • (PMID = 27942282.001).
  • [ISSN] 1918-2805
  • [Journal-full-title] Gastroenterology research
  • [ISO-abbreviation] Gastroenterology Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Keywords] NOTNLM ; Adenocarcinoma / Appendix / Histopathology / Non-invasive carcinoma / appendicitis
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47. Williams GT: Endocrine tumours of the gastrointestinal tract-selected topics. Histopathology; 2007 Jan;50(1):30-41
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  • This review provides an update on the pathogenesis and histopathological diagnosis of endocrine tumours of the gastrointestinal tract, concentrating on three different varieties whose careful assessment by pathologists is of particular clinical significance.
  • These are the four types of enterochromaffin-like cell tumour of the gastric corpus, the periampullary somatostatin-containing D-cell tumour of the duodenum, and the frequently chromogranin A-negative L-cell tumour of the appendix and large intestine.
  • In addition, the value of pathological factors in predicting the behaviour of gastrointestinal endocrine tumours and selecting therapy is discussed, and the crucial role of the pathologist in the multidisciplinary team management of these neoplasms is emphasized.
  • [MeSH-major] Carcinoid Tumor / pathology. Enteroendocrine Cells / pathology. Gastrointestinal Neoplasms / pathology. Gastrointestinal Tract / pathology
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Humans. Prognosis

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  • (PMID = 17204019.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 75
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48. Gramann T, Matter L, Pfofe D, Flury R, Jaeger P: [Metastazation into the seminal vesicles due to primary goblet cell carcinoid of the vermiform appendix. An unusual diagnostic procedure of a seminal vesicle tumor]. Urologe A; 2009 Nov;48(11):1352-5
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  • [Title] [Metastazation into the seminal vesicles due to primary goblet cell carcinoid of the vermiform appendix. An unusual diagnostic procedure of a seminal vesicle tumor].
  • [Transliterated title] Samenblasenmetastase bei primärem Becherzellkarzinoid der Appendix vermiformis. Ein aussergewöhnlicher Abklärungsgang eines Samenblasentumors.
  • A goblet cell carcinoid of the vermiform appendix was identified as the primary tumor.
  • The tumor valency, diagnostic work up, therapy and further differential diagnoses are described.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Carcinoid Tumor / pathology. Carcinoid Tumor / secondary. Genital Neoplasms, Male / pathology. Genital Neoplasms, Male / secondary. Seminal Vesicles / pathology
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / adverse effects. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Appendectomy. Appendix / pathology. Biomarkers, Tumor / analysis. Biopsy. Combined Modality Therapy. Diagnosis, Differential. Digital Rectal Examination. Fluorouracil / administration & dosage. Fluorouracil / adverse effects. Humans. Leucovorin / administration & dosage. Leucovorin / adverse effects. Magnetic Resonance Imaging. Male. Middle Aged. Organoplatinum Compounds / administration & dosage. Organoplatinum Compounds / adverse effects. Palliative Care. Patient Care Team. Peritoneal Neoplasms / pathology. Peritoneal Neoplasms / secondary. Synaptophysin / analysis

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  • (PMID = 19705095.001).
  • [ISSN] 1433-0563
  • [Journal-full-title] Der Urologe. Ausg. A
  • [ISO-abbreviation] Urologe A
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Organoplatinum Compounds; 0 / Synaptophysin; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; Folfox protocol
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49. Deschamps L, Couvelard A: Endocrine tumors of the appendix: a pathologic review. Arch Pathol Lab Med; 2010 Jun;134(6):871-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Endocrine tumors of the appendix: a pathologic review.
  • CONTEXT: Although rare, appendiceal endocrine tumors are the most common neoplasms of the appendix.
  • OBJECTIVE: To provide recent data that focus on the pathology of endocrine tumors of the appendix including classifications and guidelines for patient management.
  • CONCLUSIONS: Appendiceal endocrine tumors are separated into 2 main groups: classic endocrine tumors and goblet cell carcinoids.
  • Evaluation of their prognoses and risks of malignancy, according to these classifications, depends on several parameters including tumor size, proliferation rate, and infiltration of appendiceal wall and mesoappendix.
  • Most patients with classic endocrine tumors of the appendix have a favorable prognosis.
  • Indications for postappendectomy, complementary surgery, which are still controversial, especially for tumors between 1 and 2 cm, are presented and discussed.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Carcinoma, Neuroendocrine / pathology
  • [MeSH-minor] Appendectomy. Carcinoid Tumor / classification. Carcinoid Tumor / diagnosis. Carcinoid Tumor / pathology. Colectomy. Humans. Prognosis. World Health Organization

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  • (PMID = 20524865.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 41
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50. van Eeden S, Offerhaus GJ, Hart AA, Boerrigter L, Nederlof PM, Porter E, van Velthuysen ML: Goblet cell carcinoid of the appendix: a specific type of carcinoma. Histopathology; 2007 Dec;51(6):763-73
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  • [Title] Goblet cell carcinoid of the appendix: a specific type of carcinoma.
  • AIMS: Goblet cell carcinoid is a poorly understood tumour of the appendix.
  • METHODS AND RESULTS: The immunohistochemical expression pattern of 21 markers and the mutation status of KRas codon 12 were determined in 16 goblet cell carcinoids and compared with 14 classical carcinoids, 19 colonic adenocarcinomas and 10 appendiceal mucinous cystadeno (carcino)mas.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Biomarkers, Tumor / analysis. Carcinoid Tumor / pathology

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  • [CommentIn] Histopathology. 2008 May;52(6):770-1 [18439158.001]
  • (PMID = 18042066.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Grant] United States / NIMHD NIH HHS / MD / 1P20 MD001824
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / KRAS protein, human; 0 / Proto-Oncogene Proteins; EC 3.6.5.2 / ras Proteins
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51. Safioleas MC, Moulakakis KG, Kontzoglou K, Stamoulis J, Nikou GC, Toubanakis C, Lygidakis NJ: Carcinoid tumors of the appendix. Prognostic factors and evaluation of indications for right hemicolectomy. Hepatogastroenterology; 2005 Jan-Feb;52(61):123-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Carcinoid tumors of the appendix. Prognostic factors and evaluation of indications for right hemicolectomy.
  • BACKGROUND/AIMS: Carcinoid tumors of the appendix are thought to be the most common type of appendiceal neoplasms.
  • Although the vast majority of appendiceal carcinoids behave in a benign fashion, they are considered malignant because they all have the potential for invasion, metastasis and production of physiologically active substances.
  • Following confirmation of the diagnosis, secretion of 5-HLAA (5-Hydroxy-Inndole-Acetic Acid) was measured after a 24-hour collection of urine.
  • Also, patients with tumor size more than 1cm underwent a Somatostatin Receptor Scintigraphy (Octreoscan).
  • RESULTS: The most common site for the tumors was the tip of the appendix (18/22).
  • In the rest of the cases, the neoplasms were located in the base (4/22) and in the body (2/22), while in one patient the mesoappendix was invaded.
  • In sixteen patients the tumor size was less than 1cm, in seven patients the tumor diameter was measured to be 1 to 2cm and in one patient the tumor was 3cm.
  • Most of our patients (16/22) underwent only an appendicectomy, while in the rest of them (in the patients with tumor size between 1-2cm and in the patient with invasion of mesoappendix) a right hemicolectomy was performed.
  • No patient was found to have metastatic disease during the operation, while the patient with invasion of the mesoappendix developed metastases in the lung, two years after the operation.
  • CONCLUSIONS: Carcinoid tumors of the appendix, in most cases, are found incidentally during appendicectomies, especially in young females and usually are less than 1cm in size, which is probably the reason of the absence of metastases in all cases.
  • Histological examination and size of the tumor are important factors that contribute to the selection of the surgical treatment and both must be estimated by the surgeons to make the final choice.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Appendiceal Neoplasms / surgery. Carcinoid Tumor / pathology. Carcinoid Tumor / surgery

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  • (PMID = 15783011.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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52. Tran A, Berard A, Coombs KM: Growth and maintenance of quail fibrosarcoma QM5 cells. Curr Protoc Microbiol; 2009 Aug;Appendix 4:Appendix 4G
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  • This appendix describes techniques for culturing quail fibrosarcoma QM5 cell lines, one of the preferred cell lines in which many avian reovirus studies take place.
  • [MeSH-major] Cell Culture Techniques / methods. Cell Line, Tumor. Fibrosarcoma

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  • (PMID = 19653212.001).
  • [ISSN] 1934-8533
  • [Journal-full-title] Current protocols in microbiology
  • [ISO-abbreviation] Curr Protoc Microbiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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53. Azordegan N, Yazdankhah A, Moghadasian MH: A rare case of coexistence of carcinoid tumor of appendix vermicularis and ileal endometriosis. Arch Gynecol Obstet; 2009 Feb;279(2):183-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A rare case of coexistence of carcinoid tumor of appendix vermicularis and ileal endometriosis.
  • BACKGROUND: Carcinoid tumor is the most common tumor of appendix with overall good prognosis.
  • CASE REPORT: We here report the coexistence of carcinoid tumor of appendix and ileal endometriosis in a 37-year-old nulliparous woman who came to the emergency room with right lower abdominal pain mimicking acute appendicitis.
  • With preoperative suspicion of acute appendicitis, laparatomy was performed and revealed apparently normal looking appendix, along with a nodule in the terminal ileum.
  • Both the appendix and ileal nodule were removed.
  • Histological examinations revealed carcinoid tumor of appendix and ileal endometriosis.
  • CONCLUSION: Many cases of carcinoid tumor of the appendix and ileal endometriosis are diagnosed incidentally.
  • [MeSH-major] Appendiceal Neoplasms / complications. Carcinoid Tumor / complications. Endometriosis / complications. Ileal Diseases / complications
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Prognosis


54. Logan-Collins JM, Lowy AM, Robinson-Smith TM, Kumar S, Sussman JJ, James LE, Ahmad SA: VEGF expression predicts survival in patients with peritoneal surface metastases from mucinous adenocarcinoma of the appendix and colon. Ann Surg Oncol; 2008 Mar;15(3):738-44
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  • [Title] VEGF expression predicts survival in patients with peritoneal surface metastases from mucinous adenocarcinoma of the appendix and colon.
  • Patients with mucinous adenocarcinomas metastatic to the peritoneal surfaces can be treated with cytoreductive surgery, and both tumor grade and cytoreduction status are prognostic.
  • We hypothesized that angiogenic indices may be prognostic in patients undergoing cytoreductive surgery for mucinous adenocarcinoma of the appendix and colon.
  • RESULTS: A total of 26 males and 9 females, with a mean age of 50 years, underwent cytoreductive surgery and IPHP for mucinous adenocarcinoma of appendiceal (n = 32) or colonic (n = 3) origin.
  • With a mean follow-up of 18 months (range 1-63 months), 23 had disease recurrence and 12 were alive without recurrence.
  • CONCLUSIONS: These results suggest that markers of tumor angiogenesis may predict survival in patients with peritoneal surface metastases from mucinous adenocarcinoma.
  • These findings provoke the hypothesis that antiangiogenic therapies may be effective in patients with this devastating disease.
  • [MeSH-major] Adenocarcinoma, Mucinous / metabolism. Adenocarcinoma, Mucinous / therapy. Appendiceal Neoplasms / pathology. Appendiceal Neoplasms / therapy. Biomarkers, Tumor / biosynthesis. Peritoneal Neoplasms / metabolism. Peritoneal Neoplasms / therapy. Vascular Endothelial Growth Factor A / biosynthesis

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  • (PMID = 18043973.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A
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55. Murár E, Omaník P, Funáková M, Béder I, Horn F: [Acute scrotum is a condition requiring surgical intervention]. Rozhl Chir; 2008 Oct;87(10):517-20
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  • We retrospectively analyzed the group of 354 patients in 10 years (1997-2006) to compare the preoperative findings with the diagnosis of surgical exploration.
  • PATIENTS AND METHODS: We focused on the age of patients, incidence of nosological units of AS and preoperative and surgical diagnosis.
  • Torsion of testicular appendix or epididymis is the most frequent cause of AS in our group - 204, 59%.
  • In this group of patients ultrasound confirmed the diagnosis only in 120 patients, 65%.
  • In all patients with testicular torsion ultrasound confirmed the diagnosis, 100%.
  • In 10 boys we found testicular tumor.
  • DISCUSSION: Testicular torsion and tumor are the units in which the surgical exploration is performed without discussion.
  • Beside that, torsion of the testicular or epididymic appendix is the most frequent occurring diagnosis.

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  • (PMID = 19110944.001).
  • [ISSN] 0035-9351
  • [Journal-full-title] Rozhledy v chirurgii : měsíčník Československé chirurgické společnosti
  • [ISO-abbreviation] Rozhl Chir
  • [Language] slo
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Czech Republic
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56. Washington MK, Tang LH, Berlin J, Branton PA, Burgart LJ, Carter DK, Compton CC, Fitzgibbons PL, Frankel WL, Jessup JM, Kakar S, Minsky B, Nakhleh RE, Members of the Cancer Committee, College of American Pathologists: Protocol for the examination of specimens from patients with neuroendocrine tumors (carcinoid tumors) of the appendix. Arch Pathol Lab Med; 2010 Feb;134(2):171-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Protocol for the examination of specimens from patients with neuroendocrine tumors (carcinoid tumors) of the appendix.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Neuroendocrine Tumors / pathology
  • [MeSH-minor] Carcinoid Tumor / pathology. Carcinoid Tumor / surgery. Humans. Neoplasm Staging

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  • (PMID = 20121602.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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57. Brustmann H: Myxoglobulosis of the appendix associated with a proximal carcinoid and a pseudodiverticulum. Ann Diagn Pathol; 2006 Jun;10(3):166-8
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  • [Title] Myxoglobulosis of the appendix associated with a proximal carcinoid and a pseudodiverticulum.
  • Intraoperatively, the appendix was enlarged and distended.
  • The lumen of the appendix was tightly filled with pearl-like globules, diagnostic of myxoglobulosis, a rare variant of mucocele of the appendix.
  • A carcinoid of 2.0 cm diameter was found in the proximal region of the appendix.
  • The appendiceal mucosa showed hyperplastic-adenomatous changes.
  • The latter may be an adjunct to the proximal partial obstruction of the appendiceal lumen by the carcinoid in the development of the spheroids of myxoglobulosis.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Appendix / pathology. Carcinoid Tumor / pathology. Diverticulum, Colon / pathology. Mucocele / pathology

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  • [ErratumIn] Ann Diagn Pathol. 2006 Aug;10(4):251
  • (PMID = 16730314.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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58. Tang LH: Epithelial neoplasms of the appendix. Arch Pathol Lab Med; 2010 Nov;134(11):1612-20
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  • [Title] Epithelial neoplasms of the appendix.
  • CONTEXT: The appendix gives rise to an array of epithelial neoplasms showing glandular or neuroendocrine differentiation, and some tumors with elements of both cell types.
  • Although some appendiceal neoplasms resemble their counterparts in the small and large intestines (conventional adenocarcinoma and carcinoid tumor), the appendix also gives rise to relatively unique entities including mucinous neoplasms and goblet cell carcinoid tumors, which present a challenge in pathologic classification and clinical management.
  • OBJECTIVE: To review clinical and diagnostic issues for 3 pathologic types of epithelial neoplasms of the appendix:.
  • (1) adenocarcinoma, with specific focus on mucinous neoplasm;.
  • (2) goblet cell carcinoid tumor and associated adenocarcinoma; and (3) typical carcinoid tumor.
  • CONCLUSIONS: The most important issue in pathologic assessment of epithelial tumors of the appendix is to understand the clinical implications inherent in the diagnosis.
  • [MeSH-major] Adenocarcinoma / pathology. Appendiceal Neoplasms / pathology. Appendix / pathology. Carcinoid Tumor / pathology

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  • (PMID = 21043814.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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59. Sugarbaker PH, Bijelic L, Chang D, Yoo D: Neoadjuvant FOLFOX chemotherapy in 34 consecutive patients with mucinous peritoneal carcinomatosis of appendiceal origin. J Surg Oncol; 2010 Nov 1;102(6):576-81
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  • [Title] Neoadjuvant FOLFOX chemotherapy in 34 consecutive patients with mucinous peritoneal carcinomatosis of appendiceal origin.
  • BACKGROUND: A treatment option for patients with peritoneal mucinous carcinomatosis (PMCA) from an appendiceal neoplasm is cytoreductive surgery and perioperative intraperitoneal chemotherapy.
  • METHODS: In January of 2005 a prospective study was initiated to routinely treat patients with peritoneal dissemination of a mucinous adenocarcinoma of the appendix with neoadjuvant chemotherapy using FOLFOX.
  • In the clinical evaluation and CT evaluation, 24 (71%) and 22 (65%), respectively, had stable disease on chemotherapy.
  • [MeSH-major] Adenocarcinoma, Mucinous / drug therapy. Adenocarcinoma, Mucinous / secondary. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Appendiceal Neoplasms / pathology. Peritoneal Neoplasms / drug therapy. Peritoneal Neoplasms / secondary

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  • (PMID = 20737420.001).
  • [ISSN] 1096-9098
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; Folfox protocol
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60. Maheshwari V, Tsung A, Lin Y, Zeh HJ 3rd, Finkelstein SD, Bartlett DL: Analysis of loss of heterozygosity for tumor-suppressor genes can accurately classify and predict the clinical behavior of mucinous tumors arising from the appendix. Ann Surg Oncol; 2006 Dec;13(12):1610-6
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  • [Title] Analysis of loss of heterozygosity for tumor-suppressor genes can accurately classify and predict the clinical behavior of mucinous tumors arising from the appendix.
  • METHODS: Tissue specimens from 23 mucinous appendiceal tumors were analyzed.
  • We found an association between tumor loss of heterozygosity markers and histopathologic classification (P < .05).
  • An FMR less than .25 indicated low-grade disease, an FMR of .25 to .50 indicated intermediate grade, and an FMR greater than .5 indicated a high-grade tumor.
  • CONCLUSIONS: Mutational profiling of accumulated allelic loss and point mutational damage correlated strongly with histopathologic definitions of pseudomyxoma peritonei disease and helped to predict the prognosis of these patients.
  • FMR, along with histopathology, offers a comprehensive classification of these rare tumors.
  • [MeSH-major] Adenocarcinoma, Mucinous / genetics. Appendiceal Neoplasms / genetics. Genes, Tumor Suppressor. Loss of Heterozygosity / genetics. Pseudomyxoma Peritonei / genetics
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. DNA Mutational Analysis. DNA, Neoplasm / genetics. DNA, Neoplasm / metabolism. Female. Genes, ras / physiology. Humans. Male. Microsatellite Repeats. Middle Aged. Point Mutation. Survival Rate

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  • (PMID = 17009159.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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61. Zhang XD, He CN, Zhai JP, Zhao HF, Chen C, Shi WD: [Goblet cell carcinoid of appendix: report of two cases]. Zhonghua Bing Li Xue Za Zhi; 2006 Feb;35(2):126-7
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  • [Title] [Goblet cell carcinoid of appendix: report of two cases].
  • [MeSH-major] Appendiceal Neoplasms / pathology. Appendix / pathology. Carcinoid Tumor / pathology
  • [MeSH-minor] Adenocarcinoma, Mucinous / pathology. Aged. Appendectomy / methods. Appendicitis / pathology. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Male

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  • (PMID = 16630495.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
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62. Shapiro R, Eldar S, Sadot E, Venturero M, Papa MZ, Zippel DB: The significance of occult carcinoids in the era of laparoscopic appendectomies. Surg Endosc; 2010 Sep;24(9):2197-9
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  • BACKGROUND: We present data acquired in our institution about the incidence of incidental appendiceal carcinoids over a period of 16 years.
  • The possibility of occult carcinoids raises the question of appendectomy of a noninflamed appendix during diagnostic laparoscopy for suspected appendicitis.
  • Data were collected on all patients (n = 7592) who underwent appendectomy for the presumed diagnosis of acute appendicitis.
  • Outcome measures were the incidence of incidental carcinoids of the appendix found during appendectomies and whether the introduction of laparoscopic appendectomy should alter the surgical management of a normal-appearing appendix.
  • The diagnosis of a carcinoid tumor was not suspected in any patient before the operation, nor was a tumor identified at the time of the operation.
  • In 6 (16%) patients the appendix appeared normal at the time of the operation.
  • CONCLUSIONS: It has long been the standard of care to remove any appendix found in laparotomy for suspected appendicitis, but it is not clear what should be done during laparoscopy for suspected appendicitis when the appendix appears normal.
  • Further studies are needed to determine the clinical significance of this finding.
  • [MeSH-major] Appendectomy / methods. Appendiceal Neoplasms / epidemiology. Appendiceal Neoplasms / surgery. Carcinoid Tumor / epidemiology. Carcinoid Tumor / surgery. Laparoscopy / methods

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  • (PMID = 20174936.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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63. Nikou GC, Lygidakis NJ, Toubanakis C, Pavlatos S, Tseleni-Balafouta S, Giannatou E, Mallas E, Safioleas M: Current diagnosis and treatment of gastrointestinal carcinoids in a series of 101 patients: the significance of serum chromogranin-A, somatostatin receptor scintigraphy and somatostatin analogues. Hepatogastroenterology; 2005 May-Jun;52(63):731-41
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  • [Title] Current diagnosis and treatment of gastrointestinal carcinoids in a series of 101 patients: the significance of serum chromogranin-A, somatostatin receptor scintigraphy and somatostatin analogues.
  • BACKGROUND/AIMS: Carcinoids are relatively rare tumors that arise from neuroendocrine cells and have proved to be slow growing malignancies which involve many organs and most frequently the gastrointestinal (GI) tract.
  • Herein we present in this study 101 pts with carcinoid tumors that originated from the GI tract and pancreas.
  • Also, we analyze the clinical and pathological features, pointing out the characteristics of this group of neoplasms and describing our diagnostic and therapeutical approach, in parallel with a brief review of the literature.
  • The primary tumors originated from the GI tract in 97/101 pts (appendix 34%, small intestine 31%, stomach 14%, duodenum 6%, colon 6%, rectum 3%) and from the pancreas in 4/101 (4%).
  • The diagnosis was confirmed histologically in all cases, after surgical excision of the primary tumor or by biopsies taken during endoscopy.
  • RESULTS: Patients were referred to us with gastrointestinal symptoms or symptoms of the "carcinoid syndrome" (flushing, and diarrhea), depending mainly on the location of the primary tumors and the existence or not of metastases.
  • CgA and 5-HIAA levels were increased especially in metastatic tumors.
  • Localization of the primary tumors to facilitate surgery was made by many imaging techniques (US, CT, MRI, Enteroclysis, OCTREOSCAN) and endoscopic procedures.
  • OCTREOSCAN was positive in 94% pts with metastatic disease.
  • Seventy-four percent of the pts underwent a surgical resection of the primary tumor, while in 21%, an endoscopic polypectomy was performed.
  • All pts with metastatic tumors and positive OCTREOSCAN, were treated with Somatostatin analogues, which resulted in control of symptoms (75%), stabilization of tumor growth (71%) or tumor shrinkage (9%).
  • CONCLUSIONS: a) Tumor size (especially in appendiceal and gastric carcinoids) and, also, the dispersion of disease, highly predict the evolution of the patients;.
  • b) serum Chromogranin-A seems to be a very useful tumor marker for the diagnosis and follow-up of pts with GI carcinoids;.
  • c) the introduction of new imaging techniques and especially OCTREOSCAN contributes to a better localization of the primary tumors and their metastases, as well as, to the right decision of the appropriate medical treatment;.
  • d) surgical excision is the treatment of choice in nonmetastatic tumors; and e) in pts with metastatic disease, the administration of Somatostatin analogues improves their quality of life.
  • [MeSH-major] Biomarkers, Tumor / blood. Carcinoid Tumor / diagnosis. Chromogranins / blood. Gastrointestinal Neoplasms / diagnosis. Receptors, Somatostatin / blood. Somatostatin / analogs & derivatives
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Chromogranin A. Disease Progression. Female. Follow-Up Studies. Humans. Hydroxyindoleacetic Acid / blood. Male. Middle Aged. Palliative Care. Quality of Life

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  • (PMID = 15966194.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CHGA protein, human; 0 / Chromogranin A; 0 / Chromogranins; 0 / Receptors, Somatostatin; 51110-01-1 / Somatostatin; 54-16-0 / Hydroxyindoleacetic Acid; G083B71P98 / pentetreotide
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64. Sun WL, Hutarew G, Gradl J, Gratzl M, Denz H, Fiegl M: Successful antiangiogenic combination therapy for pseudomyxoma peritonei with bevacizumab and capecitabine. Cancer Biol Ther; 2009 Aug;8(15):1459-62
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  • We describe a case of PMP arising from an adenoma of the appendix in a 58-year-old man.
  • First, the patient underwent explorative laparotomy with ileocoecal resection, but without possibility of major tumor debulking due to adhesive gross tumor masses.
  • Upon progressive disease, a combination of bevacizumab and capecitabine led to a long term stabilization of disease and obvious improvement of performance status.
  • Our case suggests that modulation of tumor microenvironment and angiogenesis by bevacizumab, potentially augmented by moochemotherapy, may be beneficial in borderline tumors such as PMP.
  • [MeSH-major] Adenoma, Villous / secondary. Angiogenesis Inhibitors / therapeutic use. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Appendiceal Neoplasms / complications. Peritoneal Neoplasms / secondary. Pseudomyxoma Peritonei / drug therapy
  • [MeSH-minor] Antibodies, Monoclonal / administration & dosage. Antibodies, Monoclonal, Humanized. Bevacizumab. Capecitabine. Combined Modality Therapy. Deoxycytidine / administration & dosage. Deoxycytidine / analogs & derivatives. Disease Progression. Fluorouracil / administration & dosage. Fluorouracil / adverse effects. Fluorouracil / analogs & derivatives. Hernia, Inguinal / complications. Hernia, Inguinal / surgery. Humans. Ileocecal Valve / surgery. Leucovorin / administration & dosage. Leucovorin / adverse effects. Male. Middle Aged. Organoplatinum Compounds / administration & dosage. Organoplatinum Compounds / adverse effects. Treatment Outcome

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  • (PMID = 19483475.001).
  • [ISSN] 1555-8576
  • [Journal-full-title] Cancer biology & therapy
  • [ISO-abbreviation] Cancer Biol. Ther.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Organoplatinum Compounds; 0W860991D6 / Deoxycytidine; 2S9ZZM9Q9V / Bevacizumab; 6804DJ8Z9U / Capecitabine; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; Folfox protocol
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65. Sugarbaker PH: Epithelial appendiceal neoplasms. Cancer J; 2009 May-Jun;15(3):225-35
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epithelial appendiceal neoplasms.
  • The appendiceal malignancies usually arise within a mucocele.
  • The tumor within this structure can be minimally aggressive or of an invasive character.
  • If a low-grade appendiceal malignancy is removed intact, recurrence does not occur.
  • If rupture of the wall of the mucocele occurs with either low-grade or high-grade disease, the epithelial cells within will disseminate to the peritoneal surfaces.
  • If the diagnosis of peritoneal dissemination of an appendiceal malignancy has been established, a new treatment with curative intent is indicated.
  • In approximately 900 patients treated at the Washington Cancer Institute, the quantitative prognostic indicators for appendiceal cancer with peritoneal dissemination have been determined.
  • Patients with a complete cytoreduction and low-grade tumor have an 80% survival at 20 years; with high-grade tumors, the survival drops to approximately 45%.
  • The extent of malignancy present within the abdomen by the peritoneal cancer index has a significant impact on survival for both high-grade and low-grade disease.
  • The most important indicator is the completeness of cytoreduction; for both high-grade and low-grade disease, all patients with an incomplete cytoreduction have died by 10 years.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Peritoneal Neoplasms / secondary

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  • (PMID = 19556909.001).
  • [ISSN] 1528-9117
  • [Journal-full-title] Cancer journal (Sudbury, Mass.)
  • [ISO-abbreviation] Cancer J
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 25
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66. Yantiss RK, Panczykowski A, Misdraji J, Hahn HP, Odze RD, Rennert H, Chen YT: A comprehensive study of nondysplastic and dysplastic serrated polyps of the vermiform appendix. Am J Surg Pathol; 2007 Nov;31(11):1742-53
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  • [Title] A comprehensive study of nondysplastic and dysplastic serrated polyps of the vermiform appendix.
  • Although similar lesions occur in the appendix, they have never been systematically investigated.
  • We evaluated a study group of 56 serrated polyps, a control group of 17 mucinous cystadenomas, and 4 adenocarcinomas with adjacent serrated polyps of the appendix to better understand their pathogenesis.
  • We conclude that molecular features of the "serrated neoplastic pathway" are present with similar frequencies among dysplastic and nondysplastic serrated appendiceal polyps and are not highly prevalent in adjacent carcinomas.
  • These features, including BRAF mutations, may be more closely related to a serrated morphology in appendiceal polyps rather than biologically important changes.
  • [MeSH-major] Adenocarcinoma / pathology. Adenomatous Polyps / pathology. Appendix / pathology. Cecal Neoplasms / pathology. Cell Transformation, Neoplastic / pathology. Cystadenoma, Mucinous / pathology
  • [MeSH-minor] Adaptor Proteins, Signal Transducing / analysis. Adult. Aged. Aged, 80 and over. Cell Proliferation. DNA Modification Methylases / analysis. DNA Repair Enzymes / analysis. Female. Gene Expression Regulation. Humans. Ki-67 Antigen / analysis. Male. Microsatellite Instability. Middle Aged. Mucous Membrane / pathology. MutS Homolog 2 Protein / analysis. Mutation. Neoplasm Invasiveness. Nuclear Proteins / analysis. Proto-Oncogene Proteins / genetics. Proto-Oncogene Proteins B-raf / genetics. Retrospective Studies. Tumor Suppressor Protein p53 / analysis. Tumor Suppressor Proteins / analysis. beta Catenin / analysis. beta Catenin / genetics. ras Proteins / genetics

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  • [ErratumIn] Am J Surg Pathol. 2008 Jan;32(1):175. Hahn, Hejin P [added]
  • (PMID = 18059232.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / CTNNB1 protein, human; 0 / KRAS protein, human; 0 / Ki-67 Antigen; 0 / MLH1 protein, human; 0 / Nuclear Proteins; 0 / Proto-Oncogene Proteins; 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53; 0 / Tumor Suppressor Proteins; 0 / beta Catenin; EC 2.1.1.- / DNA Modification Methylases; EC 2.1.1.63 / MGMT protein, human; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf; EC 3.6.1.3 / MSH2 protein, human; EC 3.6.1.3 / MutS Homolog 2 Protein; EC 3.6.5.2 / ras Proteins; EC 6.5.1.- / DNA Repair Enzymes
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67. Yang WL, Yan CQ, Wang FJ, Wang HL: [Diagnosis and surgical treatment of carcinoid tumors of the appendix in 64 patients]. Zhonghua Zhong Liu Za Zhi; 2008 Jul;30(7):538-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Diagnosis and surgical treatment of carcinoid tumors of the appendix in 64 patients].
  • OBJECTIVE: To summarize the experience in the diagnosis and surgical treatment of carcinoid tumors of the appendix.
  • METHODS: From 1972 to 2006, 64 patients with carcinoid tumors of the appendix received surgical treatment in our hospitals.
  • The operation modes were determined according to the doctor's judgments based on the age of the patients, the nature, size, location, infiltration depth and lymph node metastasis of the tumors.
  • CONCLUSION: Carcinoid tumor of the appendix is rare with a high rate of misdiagnosis before operation.
  • Surgical resection is the only effective treatment for this disease and proper operation mode is the key to achieve good survival.
  • [MeSH-major] Appendiceal Neoplasms / diagnosis. Appendiceal Neoplasms / surgery. Carcinoid Tumor / diagnosis. Carcinoid Tumor / surgery. Diagnostic Errors
  • [MeSH-minor] Adolescent. Adult. Aged. Appendectomy. Colectomy / methods. Female. Follow-Up Studies. Humans. Liver Neoplasms / secondary. Lymph Node Excision. Lymphatic Metastasis. Male. Middle Aged. Retrospective Studies. Survival Rate. Young Adult

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  • (PMID = 19062724.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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68. Nouri K, Demmel M, Ott J, Promberger R, Huber JC, Mayerhofer K: Villous mucinous cystadenoma of the appendix in a postmenopausal woman. JSLS; 2010 Apr-Jun;14(2):296-8
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  • [Title] Villous mucinous cystadenoma of the appendix in a postmenopausal woman.
  • Instead, a cystadenoma of the appendix was discovered during laparoscopy.
  • During diagnostic laparoscopy, the cystic lesion was found to be a distended appendix.
  • Subsequent histological analysis revealed a villous mucinous cystadenoma of the appendix with low-grade intraepithelial neoplasia.
  • CONCLUSION: Gynecologists should routinely consider this disease in the differential diagnosis of right lower dumbbell abdominal cysts.
  • Eleven percent to 20% of mucoceles are caused by mucinous cystadenocarcinomas, which carry the risk of peritoneal tumor implantation caused by rupture or laparoscopic resection.

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  • (PMID = 20932390.001).
  • [ISSN] 1086-8089
  • [Journal-full-title] JSLS : Journal of the Society of Laparoendoscopic Surgeons
  • [ISO-abbreviation] JSLS
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3043589
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69. Encinas JL, Avila LF, García-Cabeza MA, Luis A, Hernández F, Martínez L, Fernández A, Olivares P, Tovar JA: [Bronchial and appendiceal carcinoid tumors]. An Pediatr (Barc); 2006 May;64(5):474-7
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  • [Title] [Bronchial and appendiceal carcinoid tumors].
  • [Transliterated title] Tumor carcinoide bronquial y apendicular.
  • BACKGROUND: Carcinoid tumor (CT) is an unusual neoplasm observed in several locations and associated with the production of vasoactive substances and occasionally with carcinoid syndrome (flushing, diarrhea, wheezing).
  • PATIENTS AND METHODS: A retrospective review of the medial records of all children with a diagnosis of CT treated in our service between 1966 and 2003 was performed.
  • Eight had CT of the appendix, of which 4 showed the typical clinical presentation of acute appendicitis.
  • Seven of these tumors were localized at the tip of the appendix and measured 2 cm or less.
  • In one patient, the tumor was located at the cecum and measured 3.5 cm.
  • In this patient, reoperation with ileocecal resection was performed.
  • An accurate diagnosis was made after a 1-year follow-up.
  • All the patients are currently disease-free.
  • CONCLUSIONS: Typical symptoms of acute appendicitis were not observed in half of patients with CT of the appendix.
  • In most CT of the appendix, simple appendicectomy was associated with an excellent prognosis.
  • Diagnosis of bronchial TC tends to be delayed and consequently CT should be considered in the differential diagnosis of children with respiratory symptoms unresponsive to standard medical treatment.
  • [MeSH-major] Appendiceal Neoplasms / diagnosis. Bronchial Neoplasms / diagnosis. Carcinoid Tumor / diagnosis

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  • (PMID = 16756890.001).
  • [ISSN] 1695-4033
  • [Journal-full-title] Anales de pediatría (Barcelona, Spain : 2003)
  • [ISO-abbreviation] An Pediatr (Barc)
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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71. Vang R, Gown AM, Wu LS, Barry TS, Wheeler DT, Yemelyanova A, Seidman JD, Ronnett BM: Immunohistochemical expression of CDX2 in primary ovarian mucinous tumors and metastatic mucinous carcinomas involving the ovary: comparison with CK20 and correlation with coordinate expression of CK7. Mod Pathol; 2006 Nov;19(11):1421-8
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  • [Title] Immunohistochemical expression of CDX2 in primary ovarian mucinous tumors and metastatic mucinous carcinomas involving the ovary: comparison with CK20 and correlation with coordinate expression of CK7.
  • Recent studies have demonstrated conflicting results regarding the value of CDX2 for distinguishing primary ovarian mucinous tumors from metastatic mucinous carcinomas in the ovary.
  • Utility of coordinate expression of cytokeratins 7 and 20 is restricted to distinction of ovarian mucinous tumors from lower gastrointestinal tract metastases and data comparing coordinate expression of all three markers is limited.
  • Immunohistochemical studies were performed to compare expression of CDX2 and cytokeratin 20, both markers of intestinal differentiation, in conjunction with coordinate expression of cytokeratin 7, in 90 mucinous tumors involving the ovary: 42 primary ovarian mucinous tumors (31 atypical proliferative (borderline) mucinous tumors (gastrointestinal type), 11 mucinous carcinomas) and 48 metastatic mucinous carcinomas of upper (pancreaticobiliary tract: 14; stomach: five) and lower (colon and rectum: 25; appendix: four) gastrointestinal tract origin.
  • Primary ovarian tumors expressed CDX2 (40%) less frequently than cytokeratin 20 (83%) (P<0.0001).
  • CDX2 expression in primary ovarian tumors (40%) was lower than CDX2 expression in metastatic carcinomas of both upper (74%; P=0.016) and lower gastrointestinal tract origin (90%; P<0.0001).
  • Cytokeratin 20 expression was similar in primary ovarian tumors (83%) and metastases of upper (89%; P=0.071) and lower gastrointestinal tract origin (93%; P=0.29).
  • Thus, as a single marker CDX2 offers some advantage over cytokeratin 20 because it is less frequently positive in primary ovarian tumors.
  • In the almost universally cytokeratin 7-positive primary ovarian tumors and metastases of upper gastrointestinal tract origin, CDX2 coordinate expression was less common in primary ovarian tumors (36%) than in metastases of upper gastrointestinal tract origin (63%) (P=0.022) whereas cytokeratin 20 coordinate expression was identical in both tumor types (79%).
  • CDX2 was comparable to cytokeratin 20 in distinguishing metastases of lower gastrointestinal tract origin (usually cytokeratin 7-negative and CDX2/cytokeratin 20 positive) from primary ovarian tumors and metastases of upper gastrointestinal tract origin (usually cytokeratin 7-positive and CDX2/cytokeratin 20 variable).
  • CDX2 provided some advantage over cytokeratin 20 for distinguishing primary ovarian mucinous tumors from metastases of upper but not lower gastrointestinal tract origin; however, the advantage in the former was limited due to the occurrence of shared coordinate expression profiles in both tumor types.
  • Cytokeratin 7 provides the predominant discriminatory value among these markers yet is limited to distinction of primary ovarian tumors from metastases of lower gastrointestinal tract origin.
  • [MeSH-major] Adenocarcinoma, Mucinous / chemistry. Biomarkers, Tumor / analysis. Gastrointestinal Neoplasms / chemistry. Homeodomain Proteins / analysis. Keratin-7 / analysis. Ovarian Neoplasms / chemistry
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Immunohistochemistry. Keratin-20 / analysis

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  • (PMID = 16980943.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CDX2 protein, human; 0 / Homeodomain Proteins; 0 / KRT20 protein, human; 0 / KRT7 protein, human; 0 / Keratin-20; 0 / Keratin-7
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72. Miyazaki K, Satoh H, Sekizawa K: Metastasis to appendix from lung adenocarcinoma. Int J Gastrointest Cancer; 2005;36(1):59-60
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  • [Title] Metastasis to appendix from lung adenocarcinoma.
  • Endoscopic evaluation revealed no obstruction, but failed to identify mucosal abnormalities in the ileocecal region.
  • He underwent a laparotomy, and tumor of the appendix, 3 x 3 cm in diameter, adhered to the surrounding tissue, but no perforation was seen.
  • The mass was excised in combination with an ileocecal resection, followed by ileocolic anastomosis.
  • Hisotologically, the neoplastic tumor cells infiltrated the submucosa, muscularis, and serosa, but mucosa of the appendix was intact, unremarkable, with no precursor lesion.
  • The tumor was morphologically similar to the lung primary tumor.
  • He was examined at regular periodic follow-ups, but died from lung cancer 12 mo after the resection of the metastatic tumor to the appendix.
  • [MeSH-major] Appendiceal Neoplasms / secondary. Lung Neoplasms / pathology

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  • [CommentOn] Int J Gastrointest Cancer. 2003;34(1):55-8 [15235136.001]
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  • (PMID = 16227637.001).
  • [ISSN] 1537-3649
  • [Journal-full-title] International journal of gastrointestinal cancer
  • [ISO-abbreviation] Int J Gastrointest Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Comment; Journal Article
  • [Publication-country] United States
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73. Steiniger B, Timphus EM, Jacob R, Barth PJ: CD27+ B cells in human lymphatic organs: re-evaluating the splenic marginal zone. Immunology; 2005 Dec;116(4):429-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adolescent. Adult. Aged. Appendix / immunology. Child. Germinal Center / immunology. Humans. Ileum / immunology. Lymph Nodes / immunology. Middle Aged. Palatine Tonsil / immunology

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  • (PMID = 16313357.001).
  • [ISSN] 0019-2805
  • [Journal-full-title] Immunology
  • [ISO-abbreviation] Immunology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD27
  • [Other-IDs] NLM/ PMC1802440
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74. Stewart JH 4th, Shen P, Russell GB, Bradley RF, Hundley JC, Loggie BL, Geisinger KR, Levine EA: Appendiceal neoplasms with peritoneal dissemination: outcomes after cytoreductive surgery and intraperitoneal hyperthermic chemotherapy. Ann Surg Oncol; 2006 May;13(5):624-34
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  • [Title] Appendiceal neoplasms with peritoneal dissemination: outcomes after cytoreductive surgery and intraperitoneal hyperthermic chemotherapy.
  • BACKGROUND: Appendiceal neoplasms frequently present with peritoneal dissemination (PD) and have a clinical course marked by bowel obstruction and subsequent death.
  • Few data have correlated outcome with appendiceal histology after cytoreductive surgery and intraperitoneal hyperthermic chemotherapy (IPHC).
  • We have reviewed our experience with cytoreductive surgery and IPHC for PD from the appendix.
  • METHODS: A total of 110 cases of PD from proven appendiceal neoplasms treated with IPHC were identified from a prospectively managed database.
  • Tumor samples were classified on pathologic review as disseminated peritoneal adenomucinosis (n = 55), peritoneal mucinous carcinomatosis (PMCA) with intermediate features (n = 18), PMCA (n = 29), or high-grade nonmucinous lesions (n = 8).
  • RESULTS: A total of 116 IPHCs were performed on 110 patients for appendiceal PD between 1993 and 2004.
  • When stratified by histology, disseminated peritoneal adenomucinosis and intermediate tumors had better 3-year survival rates (77% +/- 7% and 81% +/- 10%) than PMCA and high-grade nonmucinous lesions (35% +/- 10% and 15% +/- 14%; P = .0032 for test of differences between groups).
  • Age at presentation (P = .0134), performance status (P < .0001), time between diagnosis and IPHC (P = .0011), resection status (P = .0044), and length of hyperthermic chemoperfusion (P = .0193) were independently associated with survival.
  • CONCLUSIONS: The data show that long-term survival is anticipated in most patients who are treated with cytoreduction and IPHC for appendiceal PD.
  • In all, this work establishes a framework for the consideration of IPHC in future trials for appendiceal PD.
  • [MeSH-major] Adenocarcinoma, Mucinous / drug therapy. Adenocarcinoma, Mucinous / surgery. Appendiceal Neoplasms / pathology. Peritoneal Neoplasms / drug therapy. Peritoneal Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Chi-Square Distribution. Combined Modality Therapy. Disease Progression. Female. Humans. Hyperthermia, Induced. Male. Middle Aged. Prognosis. Retrospective Studies. Survival Rate. Treatment Outcome

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  • [CommentIn] Ann Surg Oncol. 2006 May;13(5):597-9 [16538404.001]
  • (PMID = 16538401.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / K08 CA131482
  • [Publication-type] Journal Article
  • [Publication-country] United States
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76. Greenbaum D, Friedel D: Unanticipated findings at bariatric surgery. Surg Obes Relat Dis; 2005 Jan-Feb;1(1):22-4
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  • In only three cases (one case each of carcinoid of the appendix, Sertoli-Leydig cell tumor of the ovary, and serous cystadenocarcinoma of the ovary) would there have been a significant difference in the patient's prognosis had the problem been left undiagnosed.

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  • (PMID = 16925197.001).
  • [ISSN] 1550-7289
  • [Journal-full-title] Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery
  • [ISO-abbreviation] Surg Obes Relat Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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77. Ruiz-Tovar J, Teruel DG, Castiñeiras VM, Dehesa AS, Quindós PL, Molina EM: Mucocele of the appendix. World J Surg; 2007 Mar;31(3):542-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mucocele of the appendix.
  • BACKGROUND: Mucocele of the appendix is an infrequent event, representing 0.3%-0.7% of appendiceal pathology and 8% of appendiceal tumors.
  • It is characterized by a located or diffuse distension of the appendix with a mucus-filled lumen.
  • MATERIALS AND METHODS: We describe 35 cases of mucocele of the appendix diagnosed at Ramón y Cajal Hospital between January 1985 and January 2006.
  • In 4 cases, mucocele coexisted with colorectal cancer and was an incidental finding during laparotomy performed for tumor resection.
  • Ultrasonography and computed tomography (CT) scan helped to achieve a correct diagnosis.
  • Preoperative diagnosis of mucocele was achieved in 29% of the cases; 88% of patients underwent appendectomy, 2 had ileocecal resection, and 2 others underwent right hemicolectomy.
  • We recommend follow-up of all patients with mucoceles, because sometimes they are associated with colorectal neoplasms and recurrence as pseudomyxoma peritonei.
  • [MeSH-major] Appendix. Mucocele / pathology. Mucocele / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Appendectomy. Appendiceal Neoplasms / diagnosis. Appendiceal Neoplasms / pathology. Appendiceal Neoplasms / surgery. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Treatment Outcome

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  • (PMID = 17318706.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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78. Ayhan A, Guvenal T, Salman MC, Ozyuncu O, Sakinci M, Basaran M: The role of cytoreductive surgery in nongenital cancers metastatic to the ovaries. Gynecol Oncol; 2005 Aug;98(2):235-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: During study period, nongenital cancers metastatic to the ovaries constituted 9% of all malignant ovarian neoplasms.
  • Primary cancers were breast (35), stomach (35) and colorectal (33) cancers, lymphoma (17), undetermined origin (16), appendix (7), ileum (4), pancreas (3), gallbladder cancer (2) and mesothelioma (2).
  • Comparison of median survival times for the primary sites showed a significant overall differences (P = 0.0001) and were as follows: breast 54 months, stomach 18 months, colorectal 48 months, lymphoma 181 months, unknown primary 16 months, appendix 18 months, ileum 40 months, pancreas 3 months, gallbladder 8 months and mesothelioma 20 months.
  • Surgery is essential for diagnosis of primary tumor and necessary for relief of symptoms.
  • [MeSH-major] Ovarian Neoplasms / secondary. Ovarian Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Breast Neoplasms / pathology. Colorectal Neoplasms / pathology. Female. Humans. Hysterectomy. Lymph Node Excision. Middle Aged. Ovariectomy. Retrospective Studies. Survival Rate

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  • (PMID = 15982725.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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79. Morelli U, Coccetta M, Cirocchi R, La Mura F, Napolitano V, Galanou I, Giustozzi G, Sciannameo F: An unusual case of rectal carcinoid removed by transanal endoscopic microsurgery. Minerva Chir; 2008 Aug;63(4):311-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Usually, they were found in various locations in the gastrointestinal (GI) apparatus (67%), most of them in the small intestine (25%), appendix (12%), and rectum (14%).The techniques used for their removal are various.
  • The authors present here a case of rectal carcinoid removed using the transanal endoscopic microsurgery technique, and referred to the diagnosis and treatment of this uncommon tumor.
  • Complete blood count (CBC) and laboratory data as tumor markers and urinary 5-hydroxyindoleacetic acid (5-HIAA) showed no abnormalities, while urinary vanilmandelic acid level was elevate (18 mg/24 h).
  • The histological finding demonstrated a nodule characterized by cellular proliferation, with few microscopical abnormalities, arranged in small cords with a glandular pattern, separated by dense connective tissue.
  • Histochemically the tumor cells were cytocheratins +/-, chromogranin positive, synaptophysine positive, CD56 positive and Growth Index MIB1-Ki67 which was almost zero.
  • The use of Transanal Endoscopic Microsurgery (TEM) as a safe and feasible technique for exciding rectal tumors can be easily understood, for the excellent view and precise dissection.
  • A full diagnostic course and an immunohistochemistry are mandatory for precise diagnosis of rectal carcinoid.
  • Careful attention must be paid to these tumors because of their unexpected behaviour.
  • [MeSH-major] Carcinoid Tumor / surgery. Endoscopy, Gastrointestinal / methods. Microsurgery. Rectal Neoplasms / surgery

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  • (PMID = 18607329.001).
  • [ISSN] 0026-4733
  • [Journal-full-title] Minerva chirurgica
  • [ISO-abbreviation] Minerva Chir
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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80. Wang HL, Dhall D: Goblet or signet ring cells: that is the question. Adv Anat Pathol; 2009 Jul;16(4):247-54
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  • Goblet cell carcinoid tumor is a rare mixed endocrine-exocrine neoplasm of the appendix.
  • It carries an intermediate biologic behavior between a classic carcinoid tumor and a conventional adenocarcinoma.
  • A recent retrospective study of a large number of appendiceal goblet cell carcinoids has shown that these tumors can be stratified into 3 subgroups based on careful histologic analysis: typical goblet cell carcinoid (group A); adenocarcinoma ex goblet cell carcinoid, signet ring cell type (group B); and adenocarcinoma ex goblet cell carcinoid, poorly differentiated carcinoma type (group C).
  • [MeSH-major] Adenocarcinoma / pathology. Appendiceal Neoplasms / pathology. Carcinoid Tumor / pathology. Carcinoma, Signet Ring Cell / pathology. Goblet Cells / pathology

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  • (PMID = 19546612.001).
  • [ISSN] 1533-4031
  • [Journal-full-title] Advances in anatomic pathology
  • [ISO-abbreviation] Adv Anat Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 11
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81. Cunningham JL, Janson ET, Agarwal S, Grimelius L, Stridsberg M: Tachykinins in endocrine tumors and the carcinoid syndrome. Eur J Endocrinol; 2008 Sep;159(3):275-82
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  • [Title] Tachykinins in endocrine tumors and the carcinoid syndrome.
  • OBJECTIVE: A new antibody, active against the common tachykinin (TK) C-terminal, was used to study TK expression in patients with endocrine tumors and a possible association between plasma-TK levels and symptoms of diarrhea and flush in patients with metastasizing ileocecal serotonin-producing carcinoid tumors (MSPCs).
  • METHOD: TK, serotonin and chromogranin A (CgA) immunoreactivity (IR) was studied by immunohistochemistry in tissue samples from 33 midgut carcinoids and 72 other endocrine tumors.
  • TK-IR was also seen in all serotonin-producing lung and appendix carcinoids.
  • None of the other tumors examined contained TK-IR cells.
  • CONCLUSION: We found that TK synthesis occurs in serotonin-IR tumors and that P-TK levels are significantly correlated with symptoms of flush and diarrhea in patients with MSPCs.

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  • (PMID = 18524798.001).
  • [ISSN] 1479-683X
  • [Journal-full-title] European journal of endocrinology
  • [ISO-abbreviation] Eur. J. Endocrinol.
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Tachykinins
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82. Goere D, Elias D: [Appendiceal tumors found at appendectomy]. J Chir (Paris); 2009 Oct;146 Spec No 1:36-8
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  • [Title] [Appendiceal tumors found at appendectomy].
  • [Transliterated title] Diagnostic de tumeur appendiculaire lors d'une appendicectomie.
  • There are three main histologic types of appendiceal tumor: adenoma, adenocarcinoma, and neuroendocrine tumor.
  • Neuroendocrine tumors (carcinoids) are by far the most common and account for two-third of all appendiceal tumors.
  • Rupture of any mucinous tumor-whether spontaneous or occurring during surgery-may result in pseudomyxoma peritonei; treatment of this condition requires complete resection of all lesions followed by hyperthermic intraperitoneal chemotherapy.
  • For unruptured appendiceal tumor, the appendix should be removed by a carcinologic right hemicolectomy if the tumor appears aggressive.
  • [MeSH-major] Appendectomy. Appendiceal Neoplasms / surgery
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / surgery. Adenoma / diagnosis. Adenoma / surgery. Humans. Neuroendocrine Tumors / diagnosis. Neuroendocrine Tumors / surgery. Peritoneal Neoplasms / prevention & control. Pseudomyxoma Peritonei / prevention & control. Rupture / prevention & control

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  • (PMID = 19846099.001).
  • [ISSN] 0021-7697
  • [Journal-full-title] Journal de chirurgie
  • [ISO-abbreviation] J Chir (Paris)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 7
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83. Gordon R, Burns K, Friedlich M: Goblet cell carcinoid of the appendix. Can J Surg; 2005 Jun;48(3):251-2
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  • [Title] Goblet cell carcinoid of the appendix.
  • [MeSH-major] Appendiceal Neoplasms / surgery. Carcinoid Tumor / surgery

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  • [Cites] Surg Gynecol Obstet. 1988 Jul;167(1):81-6 [3289135.001]
  • [Cites] Int Surg. 1989 Apr-Jun;74(2):109-10 [2753618.001]
  • [Cites] J Gastroenterol. 1998 Aug;33(4):582-7 [9719248.001]
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  • (PMID = 16013634.001).
  • [ISSN] 0008-428X
  • [Journal-full-title] Canadian journal of surgery. Journal canadien de chirurgie
  • [ISO-abbreviation] Can J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC3211548
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84. Tiryaki S, Ergun O, Celik A, Ulman I, Avanoglu A: Success of Malone's antegrade continence enema (MACE) from the patients' perspective. Eur J Pediatr Surg; 2010 Nov;20(6):405-7
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  • RESULTS: The indications for ACE stomas were meningomyelocele in 17 patients, anorectal malformation in 8, Hirschsprung/NID in 3, spinal tumor in 3 and traumatic spinal injury in one.
  • The vermiform appendix was used in 27 of the patients and a cecal flap was used in 5.

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  • [Copyright] © Georg Thieme Verlag KG Stuttgart · New York.
  • (PMID = 20954103.001).
  • [ISSN] 1439-359X
  • [Journal-full-title] European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift für Kinderchirurgie
  • [ISO-abbreviation] Eur J Pediatr Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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85. Theodoropoulos GE, Tsamis D, Linardoutsos D, Stamopoulos P, Zoumpouli C, Zagouri F, Michalopoulos NV: Ruptured cystadenoma of a duplicated appendix. Am Surg; 2010 Mar;76(3):341-3
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  • [Title] Ruptured cystadenoma of a duplicated appendix.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Appendix / abnormalities
  • [MeSH-minor] Biomarkers, Tumor / blood. Colectomy. Cystadenoma. Humans. Ileocecal Valve / pathology. Male. Middle Aged. Rupture, Spontaneous

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  • (PMID = 20349673.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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86. Okolicány R, Prochotský A, Jancula L, Ferák I: [Intususception of appendical cystadenoma imitating a caecal tumor]. Rozhl Chir; 2005 Dec;84(12):617-20
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  • [Title] [Intususception of appendical cystadenoma imitating a caecal tumor].
  • [Transliterated title] Intususcepcia cystadenómu apendixu imitujúca tumor céka.
  • Upon the preoperative diagnosis the appendical cystadenoma appeared as a caecal tumor or a tumor of the terminal ileum.
  • A histological, intraoperative, diagnosis was established, followed by a final histological examination of the resected tissue.
  • The authors discuss contemporary options of the preoperative diagnostic measures of the appendical tumors, stressing up all risks of aspiration cytology as well as risks of laparoscopic approach in this pathology management
  • [MeSH-major] Appendix. Cecal Diseases / diagnosis. Cecal Neoplasms / diagnosis. Cystadenoma, Mucinous / diagnosis. Intussusception / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged

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  • (PMID = 16447583.001).
  • [ISSN] 0035-9351
  • [Journal-full-title] Rozhledy v chirurgii : měsíčník Československé chirurgické společnosti
  • [ISO-abbreviation] Rozhl Chir
  • [Language] slo
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Czech Republic
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87. Knauer M, Haid A, Gruber-Mösenbacher U, Wenzl E: [Mesenteric inflammatory veno-occlusive disease (MIVOD)--a rare cause of intestinal ischemia]. Wien Klin Wochenschr; 2005 Sep;117(17):610-4
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  • [Title] [Mesenteric inflammatory veno-occlusive disease (MIVOD)--a rare cause of intestinal ischemia].
  • [Transliterated title] Mesenteric inflammatory veno-occlusive disease (MIVOD)--seltene Ursache für intestinale Ischämie.
  • Mesenteric inflammatory veno-occlusive disease (MIVOD) is a relatively recently known and not very often diagnosed form of ischemic bowel disease of low incidence und unknown etiology.
  • Suspecting intestinal ischemia or perforated appendicitis we first performed laparoscopy, which showed an inflammable tumor of cecum, ascending colon and appendix with massive adhesions to the abdominal wall.
  • The presentation of MIVOD can range from chronic inflammatory bowel disease with recurrent abdominal pain in combination with nausea, emesis and bloody diarrhea to acute abdomen.
  • All forms of hypercoagulopathy, parasitic disease, sepsis and malignancy have to be excluded.
  • [MeSH-major] Intestines / blood supply. Ischemia / diagnosis. Ischemia / prevention & control. Mesenteric Vascular Occlusion / diagnosis. Mesenteric Vascular Occlusion / surgery. Vasculitis / diagnosis. Vasculitis / surgery
  • [MeSH-minor] Colectomy. Female. Humans. Mesenteric Veins / surgery. Rare Diseases / complications. Rare Diseases / diagnosis. Rare Diseases / surgery

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  • (PMID = 16395991.001).
  • [ISSN] 0043-5325
  • [Journal-full-title] Wiener klinische Wochenschrift
  • [ISO-abbreviation] Wien. Klin. Wochenschr.
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Austria
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88. Neves GR, Chapchap P, Sredni ST, Viana CR, Mendes WL: Childhood carcinoid tumors: description of a case series in a Brazilian cancer center. Sao Paulo Med J; 2006 Jan 5;124(1):21-5
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  • [Title] Childhood carcinoid tumors: description of a case series in a Brazilian cancer center.
  • CONTEXT AND OBJECTIVE: Carcinoid tumors are very rare both in children and adults.
  • About 85% of these tumors develop in the gastrointestinal tract.
  • The objective of the present study was to describe our experience with children treated of carcinoid tumors, and investigate the frequency morphological findings and results.
  • DESIGN AND SETTING: Report on case series, at the Department of Pediatrics of Centro de Tratamento e Pesquisa Hospital do Câncer, São Paulo.
  • METHODS: This was a retrospective analysis of clinical pathological data and outcomes among children (< 18 years old) with carcinoid tumors admitted from January 1, 1990, to December 31, 2001.
  • In eight cases (89%), the primary tumor site was the appendix and in one (11%) it was the left bronchus.
  • For those with primary tumor in the appendix, the main complaint was abdominal pain, which led to appendectomy.
  • Only one patient underwent right hemicolectomy due to tumor extension into the serosa.
  • The patient with bronchial tumor underwent left pneumonectomy.
  • All patients had localized disease and are alive and free of disease.
  • CONCLUSION: Although the majority of carcinoid tumors arise from the appendix, these tumors can also occur in other primary sites.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Carcinoid Tumor / pathology
  • [MeSH-minor] Adolescent. Brazil. Child. Child, Preschool. Female. Follow-Up Studies. Humans. Immunohistochemistry. Male. Neoplasm Invasiveness. Retrospective Studies. Sex Factors

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  • (PMID = 16612458.001).
  • [ISSN] 1516-3180
  • [Journal-full-title] São Paulo medical journal = Revista paulista de medicina
  • [ISO-abbreviation] Sao Paulo Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
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89. Kiyokawa T, Young RH, Scully RE: Krukenberg tumors of the ovary: a clinicopathologic analysis of 120 cases with emphasis on their variable pathologic manifestations. Am J Surg Pathol; 2006 Mar;30(3):277-99
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  • [Title] Krukenberg tumors of the ovary: a clinicopathologic analysis of 120 cases with emphasis on their variable pathologic manifestations.
  • 120 Krukenberg tumors were analyzed with emphasis on their wide microscopic spectrum and resultant problems in differential diagnosis.
  • Sixty-three percent of the tumors were documented to be bilateral, but both ovaries were not always removed or rigorously examined microscopically.
  • The mean diameter of the tumors was 10.4 cm, and they typically had intact, bosselated external surfaces without adhesions.
  • The sectioned surfaces were typically solid and firm to edematous to gelatinous; one third of the tumors also had cysts.
  • Microscopic examination showed great variation from case to case and within individual neoplasms.
  • Multiple nodules separated by normal stroma were seen in small neoplasms and focally in many larger ones.
  • The tumors were often more cellular at their periphery and edematous to gelatinous centrally.
  • Signet-ring cells were numerous in most neoplasms (and by definition occupied at least 10% of the neoplasm) but were often absent or inconspicuous in significant areas of them.
  • Stromal luteinization was present in the tumors of the 8 pregnant patients and was seen in 14% of the nonpregnant patients.
  • Two thirds of the primary carcinomas were detected synchronously with, or subsequent to, detection of the Krukenberg tumor compounding the diagnostic difficulty posed by the cases.
  • Two thirds of the primary tumors were in the stomach; other primary sites in order of frequency were appendix, colon, breast, small intestine, rectum, gallbladder, and urinary bladder.
  • Our observations emphasize that the microscopic spectrum of the Krukenberg tumor is broader that often presented in the literature, in particular tubules, glands, and cysts often being present, and the wide pathologic differential diagnosis is discussed.
  • [MeSH-major] Krukenberg Tumor / pathology. Ovarian Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. History, 17th Century. Humans. Pregnancy

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  • (PMID = 16538048.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Historical Article; Journal Article
  • [Publication-country] United States
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90. Pai RK, Beck AH, Norton JA, Longacre TA: Appendiceal mucinous neoplasms: clinicopathologic study of 116 cases with analysis of factors predicting recurrence. Am J Surg Pathol; 2009 Oct;33(10):1425-39
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  • [Title] Appendiceal mucinous neoplasms: clinicopathologic study of 116 cases with analysis of factors predicting recurrence.
  • The classification and nomenclature of appendiceal mucinous neoplasms are controversial.
  • To determine the outcome for patients with appendiceal mucinous neoplasms and further evaluate whether they can be stratified into groups that provide prognostic information, the clinicopathologic features of 116 patients (66 with clinical follow-up) with appendiceal mucinous neoplasms were studied.
  • From a wide variety of histopathologic features assessed, the important predictors that emerged on univariate statistical analysis were presence of extra-appendiceal neoplastic epithelium (P=0.01), high-grade cytology (P<0.0001), architectural complexity (P<0.001), and invasion (P<0.001).
  • All 16 patients with mucinous neoplasms confined to the appendix and lacking high-grade cytology, architectural complexity, and invasion were alive with no recurrences at median 59 months follow-up (=mucinous adenoma).
  • One of 14 patients with low-grade cytology and acellular peritoneal mucin deposits developed recurrent tumor within the peritoneum at 45 months with no patient deaths to date (median, 48-mo follow-up) (=low-grade mucinous neoplasm with low risk of recurrence).
  • Twenty-seven patients with low-grade mucinous neoplasms with extra-appendiceal neoplastic epithelium had 1-year, 3-year, 5-year, and 10-year overall survival rates of 96%, 91%, 79%, and 46%, respectively, at median 53 months follow-up (=low-grade mucinous neoplasm with high risk of recurrence).
  • Three of the 4 patients with extra-appendiceal epithelium limited to the right lower quadrant developed full-blown peritoneal disease at 6, 41, and 99 months follow-up and 1 patient eventually died of disease.
  • Nine patients with appendiceal neoplasms with invasion or high-grade cytology and follow-up showed 1-year, 3-year, and 5-year overall survival rates of 86%, 57%, and 28% (=mucinous adenocarcinoma).
  • Appendiceal mucinous neoplasms can be stratified into 4 distinct risk groups on the basis of a careful histopathologic assessment of cytoarchitectural features and extent of disease at presentation.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Appendiceal Neoplasms / pathology. Neoplasm Recurrence, Local / epidemiology

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  • (PMID = 19641451.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Grant] United States / NLM NIH HHS / LM / T15 LM007033
  • [Publication-type] Journal Article
  • [Publication-country] United States
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91. Iwańczak B, Stawarski A, Czernik J, Bronowickip K, Iwańczak F, Pytrus T, Klempous J, Godziński J: [Diagnostic difficulties in pediatric abdominal pain with potential appendicitis]. Przegl Lek; 2007;64 Suppl 3:56-60
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  • [Transliterated title] Trudności diagnostyczne przyczyn bólów brzucha okolicy wyrostka robaczkowego u dzieci.
  • RESULTS: The most often Crohn's disease were recognized (9 children), in 2 cases with concomitant other pathologies (fecal tumor of appendix in one case and with peritoneal abscess after perforation of intestinal wall).
  • In one boy with ulcerative colitis, during exacerbation of the disease appendicitis complicated by rupture and peritonitis was observed.
  • Carcinoid of the appendix was the cause of abdominal pain in one child.
  • 3. All children with periappendipected of Crohn's disease.
  • 4. All children with equivocal presentations of appendicitis and with normal appendix during operation should undergo further diagnostic evaluation.
  • [MeSH-major] Abdominal Pain / etiology. Appendicitis / diagnosis
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Diagnosis, Differential. Female. Humans. Infant. Male

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  • (PMID = 18431916.001).
  • [ISSN] 0033-2240
  • [Journal-full-title] Przegla̧d lekarski
  • [ISO-abbreviation] Prz. Lek.
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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92. Ikeura T, Takaoka M, Shimatani M, Koyabu M, Kusuda T, Suzuki R, Sumimoto K, Okazaki K: Xanthogranulomatous inflammation of the peripancreatic region mimicking pancreatic cystic neoplasm. Intern Med; 2009;48(21):1881-4
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  • [Title] Xanthogranulomatous inflammation of the peripancreatic region mimicking pancreatic cystic neoplasm.
  • Herein, we report a case of a 73-year-old man without symptoms who was initially diagnosed with a pancreatic cystic tumor but later with XGI in the peripancreatic region.
  • Although XGI has been reported to occur in various organs or tissues, such as the gallbladder, kidney, bone, stomach, colon, appendix, lymph nodes, and soft tissues, XGI involving the pancreas or its surrounding tissues is extremely rare.
  • When a pancreatic cystic lesion does not have typical clinicoradiological features of common pancreatic cystic neoplasms, this pathologic condition should be considered in the differential diagnosis.
  • [MeSH-major] Histiocytes / pathology. Inflammation / diagnosis. Neoplasms, Cystic, Mucinous, and Serous / diagnosis. Pancreatic Diseases / diagnosis. Pancreatic Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male. Pancreatectomy

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  • (PMID = 19881238.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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93. McCluggage WG, Young RH: Primary ovarian mucinous tumors with signet ring cells: report of 3 cases with discussion of so-called primary Krukenberg tumor. Am J Surg Pathol; 2008 Sep;32(9):1373-9
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  • [Title] Primary ovarian mucinous tumors with signet ring cells: report of 3 cases with discussion of so-called primary Krukenberg tumor.
  • The distinction between a primary ovarian mucinous carcinoma or even a borderline mucinous tumor and a metastatic mucinous carcinoma may be difficult.
  • One of the most important morphologic features suggesting a metastatic mucinous carcinoma in the ovary is the presence of signet ring cells; these are considered rare in primary ovarian mucinous tumors.
  • In this study, we report 3 primary ovarian mucinous tumors with a component of signet ring cells.
  • The tumors arose in patients aged 27, 55, and 60, were unilateral, confined to the ovary and stage IA.
  • In one case, the neoplasm had the architecture of a mucinous adenofibroma but had frankly malignant cells lining glands and forming solid aggregates of cells.
  • A second tumor also had the background of an adenofibroma.
  • Investigations to exclude a gastrointestinal neoplasm in 2 cases were negative.
  • Features favoring a primary rather than a metastatic neoplasm are unilateral tumor, low stage, background of adenofibroma or cystadenoma, associated endometriosis in 1 case and an absence of features which are characteristic of secondary mucinous carcinomas in the ovary, such as surface tumor deposits, a nodular growth pattern, and lymphovascular permeation.
  • Immunohistochemistry is of limited value because of overlapping immunophenotype between a primary ovarian mucinous tumor and a metastasis from the stomach, pancreas, biliary tree, appendix, or colorectum, the most likely primary sites for a secondary exhibiting similar features.
  • Our study illustrates that signet ring cells occur rarely in a primary ovarian mucinous tumor; even when conspicuous the features differ from those of the usual Krukenberg tumor.
  • At least some cases of so-called primary Krukenberg tumor may be similar to our cases.
  • However, the designation primary Krukenberg tumor should not be used as, apart from the signet ring cells, a resemblance to a "true" Krukenberg tumor of the secondary type is limited.
  • The tumors should be classified according to the underlying background neoplasm with a notation concerning the signet ring cell component.
  • [MeSH-major] Cystadenocarcinoma, Mucinous / pathology. Krukenberg Tumor / pathology. Ovarian Neoplasms / pathology

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  • (PMID = 18670351.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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94. Dupre MP, Jadavji I, Matshes E, Urbanski SJ: Diverticular disease of the vermiform appendix: a diagnostic clue to underlying appendiceal neoplasm. Hum Pathol; 2008 Dec;39(12):1823-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diverticular disease of the vermiform appendix: a diagnostic clue to underlying appendiceal neoplasm.
  • Acquired diverticula of the vermiform appendix are rare and arise as a result of different pathogenetic mechanisms.
  • One of the etiologies includes proximally located, often unsuspected small neoplasms.
  • Although the association of appendiceal diverticulosis and neoplasia is known, it remains underemphasized in the teaching and practice of surgical pathology.
  • To investigate the frequency of appendiceal neoplasms with acquired diverticulosis, we conducted a retrospective analysis of all appendectomy specimens received in our institution for a 55-month period (January 2002-July 2006).
  • Eleven (48%) appendectomy specimens with diverticulosis also harbored an appendiceal neoplasm.
  • The association of appendiceal neoplasms with diverticulosis was statistically significant (P < .0001, 2-sided Fisher exact test).
  • Neoplastic processes included 5 well-differentiated neuroendocrine tumors (carcinoids), 3 mucinous adenomas, 1 tubular adenoma, and 2 adenocarcinomas.
  • We stress the need for meticulous gross assessment with histologic examination of the entire appendectomy specimen in cases of appendiceal diverticulosis.
  • Thorough examination is required to rule out an underlying neoplasm as a cause of diverticulosis.
  • As acquired diverticula represent a rare finding, examination of the entire appendix in this setting does not create a significant impact on the workload within the pathologic laboratory.
  • [MeSH-major] Adenocarcinoma / pathology. Appendiceal Neoplasms / pathology. Appendix / pathology. Carcinoid Tumor / pathology. Cystadenoma, Mucinous / pathology. Diverticulum / pathology

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  • (PMID = 18715614.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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95. Wu CL, Yu CC: Amyand's hernia with adenocarcinoid tumor. Hernia; 2010 Aug;14(4):423-5
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  • [Title] Amyand's hernia with adenocarcinoid tumor.
  • Also, neoplasms of the appendix is quite uncommon.
  • Adenocarcinoid tumor of the appendix was noted after the operation.
  • [MeSH-major] Appendiceal Neoplasms / complications. Appendicitis / complications. Hernia, Inguinal / complications

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  • [Cites] Dis Colon Rectum. 1972 Nov-Dec;15(6):464-5 [4645616.001]
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  • (PMID = 19756915.001).
  • [ISSN] 1248-9204
  • [Journal-full-title] Hernia : the journal of hernias and abdominal wall surgery
  • [ISO-abbreviation] Hernia
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] Adenocarcinoid tumor
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96. Suzuki O, Ono K, Sekishita Y, Fujimori M, Shiono T, Kondo S: Laparoscopic two-stage surgery for goblet cell carcinoid of the appendix: report of a case and review of the Japanese literature. Surg Laparosc Endosc Percutan Tech; 2006 Apr;16(2):106-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Laparoscopic two-stage surgery for goblet cell carcinoid of the appendix: report of a case and review of the Japanese literature.
  • Goblet cell carcinoid of the appendix is a rare clinical entity exhibiting features of both carcinoid and adenocarcinoma.
  • A 49-year-old man underwent laparoscopic appendectomy under the diagnosis of acute appendicitis.
  • A pathologic diagnosis of goblet cell carcinoid, accompanied by the aggressive proliferation, with acute appendicitis was made.
  • Subsequent laparoscopic ileocecal resection was performed, and it was verified that there were neither residual tumor nor lymph node metastases.
  • Depending upon the grade of tumor proliferation, additional resection should be considered, and our experience with this case suggests that laparoscopic 2-stage surgery is feasible for the adequate treatment of goblet cell carcinoid without complications.
  • [MeSH-major] Appendectomy / methods. Appendiceal Neoplasms / surgery. Carcinoid Tumor / surgery. Colectomy / methods. Laparoscopy / methods
  • [MeSH-minor] Anastomosis, Surgical / methods. Diagnosis, Differential. Follow-Up Studies. Humans. Male. Middle Aged

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  • (PMID = 16773013.001).
  • [ISSN] 1530-4515
  • [Journal-full-title] Surgical laparoscopy, endoscopy & percutaneous techniques
  • [ISO-abbreviation] Surg Laparosc Endosc Percutan Tech
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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97. You J, Xu L, Zheng GY, Qiu JF: [Diagnosis, treatment, and prognosis of primary appendiceal tumors: analysis of 37 cases]. Zhonghua Yi Xue Za Zhi; 2008 Jul 15;88(27):1909-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Diagnosis, treatment, and prognosis of primary appendiceal tumors: analysis of 37 cases].
  • OBJECTIVE: To investigate the pathology, diagnosis,treatment, and prognosis of primary appendiceal tumors.
  • METHODS: The clinical data of 37 patients with primary tumors of the appendix, 16 males and 21 females, aged 56 +/- 13 (35-87) hospitalized Jan.
  • All 37 cases received surgical operation with the diagnosis confirmed by pathology.
  • The pathological types included carcinoid tumor (n=12), mucinous tumor (n=17), and adenocarcinoma (n=8).
  • The 1, 3, and 5-year survival rates of the primary appendix carcinoid tumor, mucinous tumor, and adenocarcinoma were 100.0%, 100.0%, and 91.7%, 100.0%, 86.7%, and 71.5%, and 75.0%, 50.0%, and 50.0% respectively.
  • CONCLUSION: A rare disease, appendiceal tumors lack specific clinical features.
  • Intra-operative exploration and frozen section are very important for diagnosis and operation choice.
  • The prognosis of primary appendix carcinoid tumors is better.
  • [MeSH-major] Appendiceal Neoplasms / diagnosis. Appendiceal Neoplasms / surgery

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  • (PMID = 19040005.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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98. Kitagawa M, Kotani T, Yamano T, Tsurudome H, Hatakeyama T, Kuriu Y, Nishi H, Yabe M: Secondary torsion of vermiform appendix with mucinous cystadenoma. Case Rep Gastroenterol; 2007;1(1):32-7
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  • [Title] Secondary torsion of vermiform appendix with mucinous cystadenoma.
  • Torsion of the vermiform appendix is a rare disorder, which causes abdominal symptoms indistinguishable from acute appendicitis.
  • We report a case (a 34-year-old male) of secondary torsion of the vermiform appendix with mucinous cystadenoma.
  • This case was characterized by mild inflammatory responses, pentazocine-resistant abdominal pain, and appendiceal tumor, which was not enhanced by the contrast medium on computed tomography presumably because of reduced blood flow by the torsion.
  • These findings may be helpful for the preoperative diagnosis of secondary appendiceal torsion.

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  • (PMID = 21487469.001).
  • [ISSN] 1662-0631
  • [Journal-full-title] Case reports in gastroenterology
  • [ISO-abbreviation] Case Rep Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Other-IDs] NLM/ PMC3073785
  • [Keywords] NOTNLM ; Appendix / Mucinous cystadenoma / Torsion
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99. Terada T: Endometriosis of the Vermiform Appendix Presenting as a Tumor. Gastroenterology Res; 2009 Dec;2(6):353-355
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Endometriosis of the Vermiform Appendix Presenting as a Tumor.
  • : Endometriosis of the vermiform appendix is a rare condition.
  • Most patients with this disease are asymptomatic or present as acute or chronic appendicitis.
  • The author herein reports a case of appendiceal endometriosis presenting as a tumor at the appendiceal oriffice.
  • A colon endoscopy showed a tumor in the appendiceal orifice.
  • Two biopsies of the tumor showed no remarkable changes.
  • Imaging modalities including CT and MRI also revealed an appendiceal tumor.
  • Resection of appendix, cecum, ascending colon, terminal ileum, and 16 lymph nodes were performed under the clinical diagnosis of gastrointestinal stromal tumor.
  • Grossly, a tumor measuring 3 x 3 x 3 cm was recognized in the appendiceral orifice.
  • Histologically, the tumor was endometriosis consisting of islands of endometrial glands and stroma.
  • The present case suggests that appendiceal endometriosis may present as a tumor.

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  • (PMID = 27990206.001).
  • [ISSN] 1918-2805
  • [Journal-full-title] Gastroenterology research
  • [ISO-abbreviation] Gastroenterology Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Keywords] NOTNLM ; Appendix / Endometriosis / Lymph nodes
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100. Ko YH, Park SH, Jung CK, Won HS, Hong SH, Park JC, Roh SY, Woo IS, Kang JH, Hong YS, Byun JH: Clinical characteristics and prognostic factors for primary appendiceal carcinoma. Asia Pac J Clin Oncol; 2010 Mar;6(1):19-27
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical characteristics and prognostic factors for primary appendiceal carcinoma.
  • AIM: Primary adenocarcinoma of the appendix is a rare malignancy.
  • This study assessed prognostic factors affecting the clinical outcome in patients with appendiceal neoplasms.
  • The distribution of stages was: 26 (47.3%) with localized disease, five (9.1%) with regional disease, and 24 (43.6%) with distant metastatic disease.
  • Of the 34 patients who underwent curative resections of primary appendiceal carcinomas, the 3- and 5-year disease-free survival rates were 66.4% and 53.3%, respectively.
  • The recurrence rate was higher in patients with regional lymph node metastasis (HR vs node negative disease 23.4; P = 0.005) and high-grade tumors (HR vs low grade 6.3; P = 0.029).
  • CONCLUSION: High tumor grade and advanced stage were significantly predictive of poor survival outcome in patients with primary appendiceal carcinomas.
  • [MeSH-major] Adenocarcinoma / pathology. Appendiceal Neoplasms / pathology
  • [MeSH-minor] Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Prognosis. Retrospective Studies

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  • (PMID = 20398034.001).
  • [ISSN] 1743-7563
  • [Journal-full-title] Asia-Pacific journal of clinical oncology
  • [ISO-abbreviation] Asia Pac J Clin Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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