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6. Bruin SC, Verwaal VJ, Vincent A, van't Veer LJ, van Velthuysen ML: A clinicopathologic analysis of peritoneal metastases of colorectal and appendiceal origin. Ann Surg Oncol; 2010 Sep;17(9):2330-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A clinicopathologic analysis of peritoneal metastases of colorectal and appendiceal origin.
  • OBJECTIVE: To predict clinical outcome by classification of peritoneal metastases (PM) of colorectal or appendiceal origin.
  • BACKGROUND: This study investigates whether standardized histological classification can predict outcome for PM of colorectal or appendiceal origin treated with cytoreduction and hyperthermic intraperitoneal chemotherapy (HIPEC).
  • For overall survival (OS) and disease-free survival (DFS) Cox proportional-hazard models were constructed.
  • Covariates included tumor, patient, and treatment characteristics.
  • RESULTS: PM could be categorized into four groups: low-grade, well-differentiated mucinous tumor (DPAM); intermediated-grade mucinous carcinoma (PMCA-i); high-grade mucinous carcinoma (PMCA); and high-grade nonmucinous carcinoma (PCA).
  • Of PM originating from an appendix tumor, 29% were of non-DPAM type.
  • Of primary colorectal tumors, 37% resulted in mucinous PM, and another 26% of PM of colorectal origin had partly mucinous histology.
  • [MeSH-major] Adenocarcinoma, Mucinous / secondary. Appendiceal Neoplasms / pathology. Colorectal Neoplasms / pathology. Peritoneal Neoplasms / secondary
  • [MeSH-minor] Aged. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Neoplasm Staging. Prognosis. Survival Rate

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  • (PMID = 20232161.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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7. Dall'Igna P, Ferrari A, Luzzatto C, Bisogno G, Casanova M, Alaggio R, Terenziani M, Cecchetto G: Carcinoid tumor of the appendix in childhood: the experience of two Italian institutions. J Pediatr Gastroenterol Nutr; 2005 Feb;40(2):216-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Carcinoid tumor of the appendix in childhood: the experience of two Italian institutions.
  • OBJECTIVES: Although rare, carcinoid tumor of the appendix is the most common neoplasm of the gastrointestinal tract in children and adolescents.
  • It is usually an incidental finding after a laparotomy for appendectomy, with a frequency of 2 to 5 cases per 1000 appendectomies.
  • The experience with 14 cases of carcinoid reported in the appendix is described.
  • METHODS AND RESULTS: In six patients the tumor measured 1 cm or less; only in one patient did it measure 2 cm.
  • In three patients the tumor measured between 1 and 2 cm and in four the size was not known.
  • All tumors were discovered by chance, and three patients underwent further surgery as a result of suspected involvement of the margins.
  • All the patients were alive with no evidence of disease at 24 to 214 months from diagnosis.
  • In our experience, both patients with local invasiveness and the patient with a tumor larger than 2 cm had good outcomes.
  • Ileocolectomy performed in the patient with a 2-cm tumor and in another two patients with smaller tumors did not demonstrate residual disease.
  • Although the need for right hemicolectomy still remains controversial for tumors measuring more than 2 cm, the approach may be nonaggressive in case of tumors invading the serosa and the periappendiceal fat.
  • Nonaggressive treatment has been suggested by some authors in cases of tumors larger than 2 cm; however, larger series need to be evaluated.
  • [MeSH-major] Appendectomy. Appendiceal Neoplasms / diagnosis. Carcinoid Tumor / diagnosis
  • [MeSH-minor] Adolescent. Child. Colectomy / methods. Female. Humans. Ileus / surgery. Male. Neoplasm Invasiveness. Neoplasm Recurrence, Local / epidemiology. Prognosis. Treatment Outcome

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  • (PMID = 15699700.001).
  • [ISSN] 0277-2116
  • [Journal-full-title] Journal of pediatric gastroenterology and nutrition
  • [ISO-abbreviation] J. Pediatr. Gastroenterol. Nutr.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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8. Tang LH: Epithelial neoplasms of the appendix. Arch Pathol Lab Med; 2010 Nov;134(11):1612-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epithelial neoplasms of the appendix.
  • CONTEXT: The appendix gives rise to an array of epithelial neoplasms showing glandular or neuroendocrine differentiation, and some tumors with elements of both cell types.
  • Although some appendiceal neoplasms resemble their counterparts in the small and large intestines (conventional adenocarcinoma and carcinoid tumor), the appendix also gives rise to relatively unique entities including mucinous neoplasms and goblet cell carcinoid tumors, which present a challenge in pathologic classification and clinical management.
  • OBJECTIVE: To review clinical and diagnostic issues for 3 pathologic types of epithelial neoplasms of the appendix:.
  • (1) adenocarcinoma, with specific focus on mucinous neoplasm;.
  • (2) goblet cell carcinoid tumor and associated adenocarcinoma; and (3) typical carcinoid tumor.
  • CONCLUSIONS: The most important issue in pathologic assessment of epithelial tumors of the appendix is to understand the clinical implications inherent in the diagnosis.
  • [MeSH-major] Adenocarcinoma / pathology. Appendiceal Neoplasms / pathology. Appendix / pathology. Carcinoid Tumor / pathology

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  • (PMID = 21043814.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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9. Debnath D, Rees J, Myint F: Are we missing diagnostic opportunities in cases of carcinoid tumours of the appendix? Surgeon; 2008 Oct;6(5):266-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Are we missing diagnostic opportunities in cases of carcinoid tumours of the appendix?
  • OBJECTIVE: Carcinoid tumour of appendix is an uncommon condition that can potentially give rise to a variation in management.
  • We aimed to assess the occurrence and mode of presentation of carcinoid tumour of appendix, and any variation of its management.
  • The mean age of patients with carcinoid tumour (41.8 years) was significantly higher than those with non-carcinoid pathology (27.7 years) (p = 0.001).
  • The incidence of female patients was higher than the male amongst the carcinoid tumour group (female/male ratio 2.2).
  • Eight patients as well as their general practitioners (53.3%) were unaware of the diagnosis.
  • CONCLUSIONS: Carcinoid tumour of the appendix remains an incidental diagnosis.
  • There was a wide variation in involving the multidisciplinary team, conveying the diagnosis to patients as well as their general practitioners, and follow-ups.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Appendiceal Neoplasms / surgery. Carcinoid Tumor / pathology. Carcinoid Tumor / surgery

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  • (PMID = 18939372.001).
  • [ISSN] 1479-666X
  • [Journal-full-title] The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
  • [ISO-abbreviation] Surgeon
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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10. Azordegan N, Yazdankhah A, Moghadasian MH: A rare case of coexistence of carcinoid tumor of appendix vermicularis and ileal endometriosis. Arch Gynecol Obstet; 2009 Feb;279(2):183-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A rare case of coexistence of carcinoid tumor of appendix vermicularis and ileal endometriosis.
  • BACKGROUND: Carcinoid tumor is the most common tumor of appendix with overall good prognosis.
  • CASE REPORT: We here report the coexistence of carcinoid tumor of appendix and ileal endometriosis in a 37-year-old nulliparous woman who came to the emergency room with right lower abdominal pain mimicking acute appendicitis.
  • With preoperative suspicion of acute appendicitis, laparatomy was performed and revealed apparently normal looking appendix, along with a nodule in the terminal ileum.
  • Both the appendix and ileal nodule were removed.
  • Histological examinations revealed carcinoid tumor of appendix and ileal endometriosis.
  • CONCLUSION: Many cases of carcinoid tumor of the appendix and ileal endometriosis are diagnosed incidentally.
  • [MeSH-major] Appendiceal Neoplasms / complications. Carcinoid Tumor / complications. Endometriosis / complications. Ileal Diseases / complications
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Prognosis


11. Wu CL, Yu CC: Amyand's hernia with adenocarcinoid tumor. Hernia; 2010 Aug;14(4):423-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Amyand's hernia with adenocarcinoid tumor.
  • Also, neoplasms of the appendix is quite uncommon.
  • Adenocarcinoid tumor of the appendix was noted after the operation.
  • [MeSH-major] Appendiceal Neoplasms / complications. Appendicitis / complications. Hernia, Inguinal / complications

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  • [Cites] Dis Colon Rectum. 1972 Nov-Dec;15(6):464-5 [4645616.001]
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  • (PMID = 19756915.001).
  • [ISSN] 1248-9204
  • [Journal-full-title] Hernia : the journal of hernias and abdominal wall surgery
  • [ISO-abbreviation] Hernia
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] Adenocarcinoid tumor
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12. Godfrey GJ, Bakkar R, Farghaly H: Mature cystic teratoma of the appendix: a case report. Anal Quant Cytol Histol; 2010 Oct;32(5):295-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mature cystic teratoma of the appendix: a case report.
  • BACKGROUND: Teratomas very rarely arise from the appendix.
  • To our knowledge, only one prior case of mature teratoma involving the appendix has been reported in the medical literature.
  • CASE: Our case is the second reported case of mature cystic teratoma involving the appendix, and, to our knowledge, it is the first reported in a female who had two simultaneous teratomas, one arising from the appendix and one arising from the right ovary.
  • CONCLUSION: Although mature cystic teratoma is a rare tumor of the appendix, it should be considered in the differential diagnosis of appendiceal masses.
  • The differential diagnosis of appendiceal masses, including clinical and pathologic features, is discussed in detail.

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  • (PMID = 22043506.001).
  • [ISSN] 0884-6812
  • [Journal-full-title] Analytical and quantitative cytology and histology
  • [ISO-abbreviation] Anal. Quant. Cytol. Histol.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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13. Miyazaki K, Satoh H, Sekizawa K: Metastasis to appendix from lung adenocarcinoma. Int J Gastrointest Cancer; 2005;36(1):59-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastasis to appendix from lung adenocarcinoma.
  • Endoscopic evaluation revealed no obstruction, but failed to identify mucosal abnormalities in the ileocecal region.
  • He underwent a laparotomy, and tumor of the appendix, 3 x 3 cm in diameter, adhered to the surrounding tissue, but no perforation was seen.
  • The mass was excised in combination with an ileocecal resection, followed by ileocolic anastomosis.
  • Hisotologically, the neoplastic tumor cells infiltrated the submucosa, muscularis, and serosa, but mucosa of the appendix was intact, unremarkable, with no precursor lesion.
  • The tumor was morphologically similar to the lung primary tumor.
  • He was examined at regular periodic follow-ups, but died from lung cancer 12 mo after the resection of the metastatic tumor to the appendix.
  • [MeSH-major] Appendiceal Neoplasms / secondary. Lung Neoplasms / pathology

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  • [CommentOn] Int J Gastrointest Cancer. 2003;34(1):55-8 [15235136.001]
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  • (PMID = 16227637.001).
  • [ISSN] 1537-3649
  • [Journal-full-title] International journal of gastrointestinal cancer
  • [ISO-abbreviation] Int J Gastrointest Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Comment; Journal Article
  • [Publication-country] United States
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1
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4. Stathis A, Hotte S, Hirte H, Chen EX, Webster S, Iacobucci A, McGill S, Wang L, Espinoza-Delgado I, Siu LL: Phase I study of intravenous decitabine in combination with oral vorinostat in patients with advanced solid tumors and non-Hodgkin's lymphomas (NHL). J Clin Oncol; 2009 May 20;27(15_suppl):3528

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Phase I study of intravenous decitabine in combination with oral vorinostat in patients with advanced solid tumors and non-Hodgkin's lymphomas (NHL).
  • METHODS: Patients (pts) with advanced solid tumors or relapsed/refractory NHL are eligible.
  • Demographics: median age 61 (range 31-76), F:M = 13:14, ECOG 0:1:2 = 8:16:3, tumor types: 24 solid tumor and 3 NHL.
  • Disease stabilization for 4 or more cycles was observed in 7 out of 22 (31.8%) evaluable pts (two with breast and one each of thymus, colon, pancreatic, appendix and non-small cell lung cancers).
  • Prolonged disease stabilization has been observed in multiple tumor types.

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  • (PMID = 27961316.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. Stintzing S, Hoffmann RT, Heinemann V, Kufeld M, Muacevic A: Robotic radiosurgery of liver metastases of solid tumors. J Clin Oncol; 2009 May 20;27(15_suppl):e15049

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Robotic radiosurgery of liver metastases of solid tumors.
  • We here report the therapeutic efficacy of a robotic radiosurgery device for local control of liver metastases of solid tumors.
  • METHODS: Patients with liver metastases not qualifying for surgery were treated with single session radiosurgery (24 Gy) using robotic image-guided real-time tumor tracking.
  • For inclusion into the radiosurgery treatment protocol, tumor volumes had to be smaller than 80cc.
  • Metastases (n=27) originated from: colon (12), rectum (2), pancreas (2), lung (1), bladder (2), malignant melanoma (1), stomach (1), cholangiocellular carcinoma (2), breast (1), ovary (1), appendix (1) and endometrium (1).
  • Median tumor volume was 21cc (range 2.2-79.3).
  • 23 pts (85%) reached local control of the disease, 4 pts (15%) had local recurrence.
  • CONCLUSIONS: Robotic radiosurgery with image-guided real-time tumor tracking of liver metastases is a new and promising treatment approach for pts not eligible for surgical resection and might enhance the possibilities of multidisciplinary oncological treatment concepts.

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  • (PMID = 27964438.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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16. Friedrich M, Poleska W, Baltzer J, Salehin D: Treatment of pseudomyxoma peritonei by intraoperative and intraperitoneal chemotherapy. J Clin Oncol; 2009 May 20;27(15_suppl):e16540

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • : e16540 Background: Pseudomyxoma peritonei occurs mostly in conjunction with the type of intestinal mucinous borderline tumour and is characterized by building up a lot of mucus pour of cells.
  • The most common tumor is the pseudomyxoma peritoneii with mucinous borderline tumours of the ovaries or with mucinous tumours of the appendix, normally without showing a rupture of the ovarian tumour pre- or intraoperatively.
  • The diagnosis of pseudomyxoma peritonei is mainly difficult and guidelines for the treatment are unknown.
  • METHODS: In the period from 1991 to 2008, 52 patients with pseudomyxoma peritonei were treated by tumour debulking and intraoperative and intraperitoneal chemotherapy with Mitoxantron (40 mg in 300 ml of NaCl over 72 hours).
  • During the tumour debulking a CUSA system was used.
  • There were the following histologies: mucinous cystadenoma of the ovary n = 29, mucinous cystadenoma of the appendix n = 10, mucinous cystadenocarcinoma n = 13.
  • CONCLUSIONS: The instillation of mitoxantron intraperitoneally and intraoperatively is an effective and safe therapy without any side effects after maximal tumour debulking of pseudomyxoma peritoneii.

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  • (PMID = 27960827.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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17. Goere D, Elias D: [Appendiceal tumors found at appendectomy]. J Chir (Paris); 2009 Oct;146 Spec No 1:36-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Appendiceal tumors found at appendectomy].
  • [Transliterated title] Diagnostic de tumeur appendiculaire lors d'une appendicectomie.
  • There are three main histologic types of appendiceal tumor: adenoma, adenocarcinoma, and neuroendocrine tumor.
  • Neuroendocrine tumors (carcinoids) are by far the most common and account for two-third of all appendiceal tumors.
  • Rupture of any mucinous tumor-whether spontaneous or occurring during surgery-may result in pseudomyxoma peritonei; treatment of this condition requires complete resection of all lesions followed by hyperthermic intraperitoneal chemotherapy.
  • For unruptured appendiceal tumor, the appendix should be removed by a carcinologic right hemicolectomy if the tumor appears aggressive.
  • [MeSH-major] Appendectomy. Appendiceal Neoplasms / surgery
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / surgery. Adenoma / diagnosis. Adenoma / surgery. Humans. Neuroendocrine Tumors / diagnosis. Neuroendocrine Tumors / surgery. Peritoneal Neoplasms / prevention & control. Pseudomyxoma Peritonei / prevention & control. Rupture / prevention & control

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  • (PMID = 19846099.001).
  • [ISSN] 0021-7697
  • [Journal-full-title] Journal de chirurgie
  • [ISO-abbreviation] J Chir (Paris)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 7
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18. Pitiakoudis M, Kirmanidis M, Tsaroucha A, Christianakis E, Filippou D, Sivridis E, Simopoulos C: Carcinoid tumor of the appendix during pregnancy. A rare case and a review of the literature. J BUON; 2008 Apr-Jun;13(2):271-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Carcinoid tumor of the appendix during pregnancy. A rare case and a review of the literature.
  • We present a rare case of a carcinoid tumor of the appendix that was diagnosed during pregnancy in a 24-year-old female.
  • Only few similar cases were found in the literature reporting appendiceal carcinoid tumor during pregnancy.
  • [MeSH-major] Appendiceal Neoplasms / surgery. Carcinoid Tumor / surgery. Pregnancy Complications, Neoplastic / pathology. Pregnancy Complications, Neoplastic / surgery

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  • (PMID = 18555477.001).
  • [ISSN] 1107-0625
  • [Journal-full-title] Journal of B.U.ON. : official journal of the Balkan Union of Oncology
  • [ISO-abbreviation] J BUON
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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19. Korkontzelos I, Papanicolaou S, Tsimoyiannis I, Kitsiou E, Stefos T, Tsanadis G, Antoniou N: Large carcinoid tumor of the appendix during pregnancy. Eur J Obstet Gynecol Reprod Biol; 2005 Feb 1;118(2):255-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Large carcinoid tumor of the appendix during pregnancy.
  • Diagnosis of acute appendicitis is considered more difficult in pregnant than in non-pregnant women.
  • The appendicial carcinoid tumor is a lesion that most frequently is discovered incidentally in the removed organ.
  • We report a rare case of an unruptured acute appendicitis during pregnancy, which proved to be a large carcinoid tumor.
  • [MeSH-major] Appendiceal Neoplasms / diagnosis. Carcinoid Tumor / diagnosis. Pregnancy Complications, Neoplastic

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  • (PMID = 15653215.001).
  • [ISSN] 0301-2115
  • [Journal-full-title] European journal of obstetrics, gynecology, and reproductive biology
  • [ISO-abbreviation] Eur. J. Obstet. Gynecol. Reprod. Biol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Ireland
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20. Chetty R, Serra S: Lipid-rich and clear cell neuroendocrine tumors ("carcinoids") of the appendix: potential confusion with goblet cell carcinoid. Am J Surg Pathol; 2010 Mar;34(3):401-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Lipid-rich and clear cell neuroendocrine tumors ("carcinoids") of the appendix: potential confusion with goblet cell carcinoid.
  • The so-called clear cell change has been described in neuroendocrine tumors at several locations.
  • Those associated with von Hippel Lindau disease are pathognomonically "clear" and the cytoplasmic appearance has been ascribed to intracytoplasmic lipid.
  • However, lipid has not been demonstrated in all cases of clear cell carcinoid tumors.
  • Such variants have not been described in carcinoid tumors of the appendix and cases with a prominent proportion of clear or more correctly, lipid-rich cytoplasm may bear a superficial resemblance to goblet cell carcinoid and/or signet ring adenocarcinoma.
  • Seven cases, in 5 females and 2 males ranging in age from 22 to 65 years, were noted to have a population of lipid-rich and vacuolated clear cells accounting for 25% or more of the tumor population.
  • The carcinoid tumors were incidental in all cases with 4 of patients presenting with appendicitis, 2 with concomitant mucinous cystadenocarcinomas of the appendix and 1 with an adenocarcinoma of the ascending colon.
  • Morphologically, the tumors had a nested and trabecular pattern and were composed of an admixture of microvesicular and clear lipid-rich cells.
  • None of the patients have shown evidence of recurrent disease.
  • The importance of recognizing this variant of carcinoid tumor in the appendix is to avoid confusion with goblet cell carcinoid tumors with or without a signet ring adenocarcinoma.
  • The presence of multi-vacuolated, foamy and clear cells, some resembling signet ring or goblet cells, in otherwise classic carcinoid tumors is rare but should be considered in this context in the appendix.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Carcinoid Tumor / pathology. Lipids / analysis
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Cytoplasm / chemistry. Cytoplasm / pathology. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Incidental Findings. Male. Middle Aged. Prognosis. Vacuoles / chemistry. Vacuoles / pathology. Young Adult

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  • (PMID = 20139759.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Lipids
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21. O'Donnell ME, Badger SA, Beattie GC, Carson J, Garstin WI: Malignant neoplasms of the appendix. Int J Colorectal Dis; 2007 Oct;22(10):1239-48

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant neoplasms of the appendix.
  • BACKGROUND: Appendiceal neoplasms, first described in 1882, are still rare, with pre-operative diagnosis invariably difficult.
  • MATERIALS AND METHODS: A retrospective histopathological review of all appendicectomy specimens was completed between April 1994 and December 2003 to identify patients diagnosed with malignant neoplasms.
  • A literature search of the PubMed database was then performed using the medical search headings; appendix, tumour, neoplasm and malignancy.
  • Other appendiceal pathologies were identified after appendicectomies, hemicolectomy and oophorectomy.
  • CONCLUSIONS: From our own experience and a subsequent review of the literature, we recommend right hemicolectomy as the treatment of choice for all malignant appendiceal neoplasms, except for small CCT less than 2 cm in diameter at the tip of the appendix, with a low proliferative index, without angiolymphatic or mesoappendiceal extension.
  • [MeSH-major] Appendiceal Neoplasms / diagnosis. Appendiceal Neoplasms / therapy

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  • (PMID = 17447078.001).
  • [ISSN] 0179-1958
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article; Meta-Analysis
  • [Publication-country] Germany
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22. Hirsch I, Kasper HU, Brabender J, Hölscher AH, Dienes HP: [Adenocarcinoid of the appendix vermiformis]. Pathologe; 2005 May;26(3):231-5
MedlinePlus Health Information. consumer health - Carcinoid Tumors.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Adenocarcinoid of the appendix vermiformis].
  • [Transliterated title] Adenokarzinoid der Appendix vermiformis.
  • Adenocarcinoids are rare tumors with histological features of both carcinoid tumor and adenocarcinoma.
  • Due to the positive surgical margin and the tumor expansion a hemicolectomy was performed.
  • It is thought that appendectomy is sufficient in case of small tumors in the tip of the appendix.
  • [MeSH-major] Adenocarcinoma / pathology. Appendiceal Neoplasms / pathology. Carcinoid Tumor / pathology

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  • (PMID = 15378268.001).
  • [ISSN] 0172-8113
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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23. Yang WL, Yan CQ, Wang FJ, Wang HL: [Diagnosis and surgical treatment of carcinoid tumors of the appendix in 64 patients]. Zhonghua Zhong Liu Za Zhi; 2008 Jul;30(7):538-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Diagnosis and surgical treatment of carcinoid tumors of the appendix in 64 patients].
  • OBJECTIVE: To summarize the experience in the diagnosis and surgical treatment of carcinoid tumors of the appendix.
  • METHODS: From 1972 to 2006, 64 patients with carcinoid tumors of the appendix received surgical treatment in our hospitals.
  • The operation modes were determined according to the doctor's judgments based on the age of the patients, the nature, size, location, infiltration depth and lymph node metastasis of the tumors.
  • CONCLUSION: Carcinoid tumor of the appendix is rare with a high rate of misdiagnosis before operation.
  • Surgical resection is the only effective treatment for this disease and proper operation mode is the key to achieve good survival.
  • [MeSH-major] Appendiceal Neoplasms / diagnosis. Appendiceal Neoplasms / surgery. Carcinoid Tumor / diagnosis. Carcinoid Tumor / surgery. Diagnostic Errors
  • [MeSH-minor] Adolescent. Adult. Aged. Appendectomy. Colectomy / methods. Female. Follow-Up Studies. Humans. Liver Neoplasms / secondary. Lymph Node Excision. Lymphatic Metastasis. Male. Middle Aged. Retrospective Studies. Survival Rate. Young Adult

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  • (PMID = 19062724.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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24. O'Donnell ME, Carson J, Garstin WI: Surgical treatment of malignant carcinoid tumours of the appendix. Int J Clin Pract; 2007 Mar;61(3):431-7
MedlinePlus Health Information. consumer health - Carcinoid Tumors.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical treatment of malignant carcinoid tumours of the appendix.
  • Since their first description in 1882, malignant neoplasms of the appendix still remain rare.
  • Malignant carcinoid tumours are the most common accounting for 85% of all appendiceal neoplasms.
  • Preoperative diagnosis is invariably difficult, and precise treatment protocols for these neoplasms remain unclear.
  • Other appendiceal pathologies were identified following hemicolectomy and oophorectomy.
  • However, small CCTs less than 2 cm in diameter at the tip of the appendix, with a low proliferative index, without angiolymphatic or mesoappendiceal extension can be treated by appendicectomy.
  • Following oncological assessment, further adjuvant therapy should be considered for patients with advanced disease.
  • [MeSH-major] Appendectomy / methods. Appendiceal Neoplasms / surgery. Carcinoid Tumor / surgery. Colectomy / methods

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  • (PMID = 16911574.001).
  • [ISSN] 1368-5031
  • [Journal-full-title] International journal of clinical practice
  • [ISO-abbreviation] Int. J. Clin. Pract.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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25. Huang B, Di MJ, Liu HS, Qiu LL, Sun LJ, Xu JP: [Primary malignant tumor of the appendix: clinicopathological analysis of 22 cases]. Zhejiang Da Xue Xue Bao Yi Xue Ban; 2009 Mar;38(2):194-8
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  • [Title] [Primary malignant tumor of the appendix: clinicopathological analysis of 22 cases].
  • OBJECTIVE: To investigate the clinicopathological and immunohistochemical features of primary malignant tumor of the appendix.
  • METHODS: The clinical data were reviewed; and histopathological and immunohistochemical features were analyzed in 22 cases with primary malignant tumor of the appendix.
  • RESULT: In 22 cases of primary malignant tumor of the appendix, 19 cases were carcinoid and 3 were adenocarcinoma.
  • CONCLUSION: Immunohistochemistry is useful in diagnosis of primary malignant tumor of the appendix, a rare type of cancer.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Carcinoid Tumor / pathology
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / pathology. Adenocarcinoma / surgery. Adolescent. Adult. Aged. Female. Humans. Immunohistochemistry. Male. Middle Aged. Young Adult

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  • (PMID = 19363829.001).
  • [ISSN] 1008-9292
  • [Journal-full-title] Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences
  • [ISO-abbreviation] Zhejiang Da Xue Xue Bao Yi Xue Ban
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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26. Yajima N, Wada R, Yamagishi S, Mizukami H, Itabashi C, Yagihashi S: Immunohistochemical expressions of cytokeratins, mucin core proteins, p53, and neuroendocrine cell markers in epithelial neoplasm of appendix. Hum Pathol; 2005 Nov;36(11):1217-25
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistochemical expressions of cytokeratins, mucin core proteins, p53, and neuroendocrine cell markers in epithelial neoplasm of appendix.
  • Epithelial neoplasms of appendix are infrequent, and their pathological features are not fully characterized.
  • We collected 33 cases of appendiceal tumors and examined immunohistochemically the expression of cytokeratins (CK, CK7, and CK20), mucin core protein (MUC1, MUC2, MUC5AC, and MUC6), E-cadherin, chromogranin A, and p53 protein.
  • Clinically, mucinous tumors were predominant in females.
  • Immunohistochemically, all the tumors expressed CK20, whereas CK7 was positive in one third of the cases.
  • Similarly, MUC2 was expressed in all the tumors, whereas MUC1 and MUC5AC were detected in about a half of the cases.
  • Although chromogranin A-positive cells are generally sparse in normal appendix, they were more common in mucinous tumors than in nonmucinous tumors.
  • Contrary to the previous data reported (Mod Pathol 2002;15:599-605), mucinous carcinoma exhibited a higher frequency of p53-positive cells (mean 29%) compared with mucinous adenoma (2.8%) (P < .001), whereas nonmucinous tumors showed high levels of p53-positive cells to similar extent (51%-67%) in both adenoma and carcinoma.
  • The high expression of p53 protein coincided with the presence of mutations in multiple sites of TP53 gene in mucinous tumors.
  • This is the first report that characterized the immunophenotypic profile of appendiceal epithelial neoplasms with an emphasis of a higher frequency of p53 positivity in mucinous carcinoma cases compared with mucinous adenoma in the appendix.
  • [MeSH-major] Appendiceal Neoplasms / metabolism. Biomarkers, Tumor / analysis. Keratins / biosynthesis. Mucins / biosynthesis. Neoplasms, Glandular and Epithelial / metabolism. Tumor Suppressor Protein p53 / biosynthesis


27. Kim KJ, Moon W, Park MI, Park SJ, Lee SH, Chun BK: Gastrointestinal stromal tumor of appendix incidentally diagnosed by appendiceal hemorrhage. World J Gastroenterol; 2007 Jun 21;13(23):3265-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gastrointestinal stromal tumor of appendix incidentally diagnosed by appendiceal hemorrhage.
  • Gastrointestinal stromal tumor is rare, which arises from the mesenchymal tissues in the gastrointestinal tract, and it is extremely rare in the appendix.
  • Although the annual incidence of lower gastrointestinal bleeding has been increasing, bleeding related to the appendix is quite rare.
  • We herein present a very rare case of gastrointestinal stromal tumor incidentally found by appendiceal hemorrhage.
  • [MeSH-major] Appendiceal Neoplasms / diagnosis. Cecal Diseases / etiology. Gastrointestinal Hemorrhage / etiology. Gastrointestinal Stromal Tumors / diagnosis

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  • (PMID = 17589911.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4436618
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28. Chetty R, Klimstra DS, Henson DE, Albores-Saavedra J: Combined classical carcinoid and goblet cell carcinoid tumor: a new morphologic variant of carcinoid tumor of the appendix. Am J Surg Pathol; 2010 Aug;34(8):1163-7
MedlinePlus Health Information. consumer health - Carcinoid Tumors.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Combined classical carcinoid and goblet cell carcinoid tumor: a new morphologic variant of carcinoid tumor of the appendix.
  • Carcinoid tumors are the most common neoplasms of the appendix.
  • Goblet cell carcinoid has been regarded as a distinctive tumor type, not related to classic carcinoids, and to our knowledge combinations of these 2 tumor types have not been described in detail.
  • In this report, we describe 5 cases of combined classical carcinoid and goblet cell carcinoid (GCC) tumors of the appendix.
  • Four men and 1 woman, (mean age 53.4 y) presented with acute appendicitis (4 cases), whereas 1 presented with a pelvic mass owing to widespread pelvic disseminated disease.
  • The tumors (0.6 to 6.0 cm) were located in the mid-portion and the tip of the appendix.
  • Four patients are alive and asymptomatic, whereas the patient with disseminated pelvic disease died 6 months after surgery.
  • All 5 appendiceal tumors had microscopic features of both classical carcinoid and GCC, either intimately admixed or separate but closely apposed.
  • The extent of the 2 components varied, with classical carcinoid representing 60% to 90% of the tumor.
  • In view of the fact that these combined carcinoid tumors appear to behave more as goblet cell carcinoids, detailed microscopic examination of classical carcinoid tumors of the appendix is suggested and larger series with longer follow-up is required to ascertain the true biologic potential of this unique form of combined carcinoid tumor of the appendix.
  • The occurrence of both carcinoid types in the same appendices suggests a closer histogenetic relationship than previously believed, although the possibility that the 2 components represent separate, independent primaries ("collision tumors") can also be considered.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Carcinoid Tumor / pathology. Goblet Cells / pathology. Mixed Tumor, Malignant / pathology
  • [MeSH-minor] Appendectomy. Biomarkers, Tumor / analysis. Colectomy. Female. Humans. Immunohistochemistry. Male. Middle Aged. Mitotic Index. Neoplasm Invasiveness. Treatment Outcome

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  • [CommentIn] Am J Surg Pathol. 2011 Aug;35(8):1248-50 [21753706.001]
  • (PMID = 20631606.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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29. Gramann T, Matter L, Pfofe D, Flury R, Jaeger P: [Metastazation into the seminal vesicles due to primary goblet cell carcinoid of the vermiform appendix. An unusual diagnostic procedure of a seminal vesicle tumor]. Urologe A; 2009 Nov;48(11):1352-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Metastazation into the seminal vesicles due to primary goblet cell carcinoid of the vermiform appendix. An unusual diagnostic procedure of a seminal vesicle tumor].
  • [Transliterated title] Samenblasenmetastase bei primärem Becherzellkarzinoid der Appendix vermiformis. Ein aussergewöhnlicher Abklärungsgang eines Samenblasentumors.
  • A goblet cell carcinoid of the vermiform appendix was identified as the primary tumor.
  • The tumor valency, diagnostic work up, therapy and further differential diagnoses are described.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Carcinoid Tumor / pathology. Carcinoid Tumor / secondary. Genital Neoplasms, Male / pathology. Genital Neoplasms, Male / secondary. Seminal Vesicles / pathology
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / adverse effects. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Appendectomy. Appendix / pathology. Biomarkers, Tumor / analysis. Biopsy. Combined Modality Therapy. Diagnosis, Differential. Digital Rectal Examination. Fluorouracil / administration & dosage. Fluorouracil / adverse effects. Humans. Leucovorin / administration & dosage. Leucovorin / adverse effects. Magnetic Resonance Imaging. Male. Middle Aged. Organoplatinum Compounds / administration & dosage. Organoplatinum Compounds / adverse effects. Palliative Care. Patient Care Team. Peritoneal Neoplasms / pathology. Peritoneal Neoplasms / secondary. Synaptophysin / analysis

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  • Hazardous Substances Data Bank. FLUOROURACIL .
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  • (PMID = 19705095.001).
  • [ISSN] 1433-0563
  • [Journal-full-title] Der Urologe. Ausg. A
  • [ISO-abbreviation] Urologe A
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Organoplatinum Compounds; 0 / Synaptophysin; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; Folfox protocol
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30. Okolicány R, Prochotský A, Jancula L, Ferák I: [Intususception of appendical cystadenoma imitating a caecal tumor]. Rozhl Chir; 2005 Dec;84(12):617-20

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Intususception of appendical cystadenoma imitating a caecal tumor].
  • [Transliterated title] Intususcepcia cystadenómu apendixu imitujúca tumor céka.
  • Upon the preoperative diagnosis the appendical cystadenoma appeared as a caecal tumor or a tumor of the terminal ileum.
  • A histological, intraoperative, diagnosis was established, followed by a final histological examination of the resected tissue.
  • The authors discuss contemporary options of the preoperative diagnostic measures of the appendical tumors, stressing up all risks of aspiration cytology as well as risks of laparoscopic approach in this pathology management
  • [MeSH-major] Appendix. Cecal Diseases / diagnosis. Cecal Neoplasms / diagnosis. Cystadenoma, Mucinous / diagnosis. Intussusception / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged

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  • (PMID = 16447583.001).
  • [ISSN] 0035-9351
  • [Journal-full-title] Rozhledy v chirurgii : měsíčník Československé chirurgické společnosti
  • [ISO-abbreviation] Rozhl Chir
  • [Language] slo
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Czech Republic
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31. Chatelain D, Brevet M, Fuks D, Yzet T, Verhaeghe P, Regimbeau JM, Lauwers G, Sevestre H: [Inflammatory fibroid polyp, a rare tumor of the appendix]. Gastroenterol Clin Biol; 2008 Mar;32(3):274-7
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Inflammatory fibroid polyp, a rare tumor of the appendix].
  • [Transliterated title] Le polype fibroïde inflammatoire, une tumeur rare de l'appendice.
  • We report the rare occurrence of an inflammatory fibroid polyp of the appendix.
  • CT-scan showed an 8 cm appendiceal mass and a laparoscopic appendectomy was consequently performed.
  • On microscopic examination, the tumor consisted of spindle cells dispersed in a loose fibromyxoid stroma containing numerous blood cells and inflammatory cells with abundant eosinophils.
  • On immunohistochemistry, the spindle tumor cells were positive for vimentin, fascin and focally for CD34 and CD35.
  • Inflammatory fibroid polyp is a rare benign mesenchymal tumor of the gastrointestinal tract rarely reported in the appendix.
  • This tumor shares some common pathologic features with the myofibroblatic inflammatory tumor but they are two different entities.
  • The pathogenesis of this tumor remains unclear but fascin and CD35 immunoreactivity of the tumor cells suggests a probable dendritic cell origin.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Intestinal Polyps / pathology. Leiomyoma / pathology

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  • (PMID = 18353580.001).
  • [ISSN] 0399-8320
  • [Journal-full-title] Gastroentérologie clinique et biologique
  • [ISO-abbreviation] Gastroenterol. Clin. Biol.
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / CR1 protein, human; 0 / Carrier Proteins; 0 / Microfilament Proteins; 0 / Receptors, Complement 3b; 0 / Vimentin; 146808-54-0 / fascin
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32. Pahlavan PS, Kanthan R: Goblet cell carcinoid of the appendix. World J Surg Oncol; 2005 Jun 20;3:36

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Goblet cell carcinoid of the appendix.
  • BACKGROUND: Goblet cell carcinoid (GCC) of the appendix is a rare neoplasm that share histological features of both adenocarcinoma and carcinoid tumor.
  • The clinical presentations of this neoplasm are also varied.
  • This review summarizes the published literature on GCC of the appendix.
  • The focus is on its diagnosis, histopathological aspects, clinical manifestations, and management.
  • METHODS: Published studies in the English language between 1966 to 2004 were identified through Medline keyword search utilizing terms "goblet cell carcinoid," "adenocarcinoid", "mucinous carcinoid" and "crypt cell carcinoma" of the appendix.
  • RESULTS: Based on the review of 57 published papers encompassing nearly 600 diagnosed patients, the mean age of presentation for GCC of the appendix was 58.89 years with equal representation in both males and females.
  • Accurate diagnosis of this neoplasm requires astute observations within an acutely inflamed appendix as this neoplasm has a prominent pattern of submucosal growth and usually lacks the formation of a well-defined tumor mass.
  • Concomitant distant metastasis at diagnosis was present in 11.16% of patients with the ovaries being the most common site in 3.60% followed by disseminated abdominal carcinomatosis in 1.03%.
  • Local lymph node involvement was seen in 8.76% of patients at the time of diagnosis.
  • GCC's of the appendix remains a neoplasm of unpredictable biological behavior and thus warrants lifelong surveillance for recurrence of the disease upon diagnosis and successful surgical extirpation.
  • CONCLUSION: GCC of the appendix is a rare neoplasm.
  • Due to its wide range of presentation, this tumor should be considered as a possible diagnosis in many varied situations leading to abdominal surgery.
  • The advocated plan of management recommended for patients with tumors that involve the adjacent caecum or with high-grade tumors with histological features such as an increased mitotic rate involve initial appendectomy with completion right hemicolectomy due to the high possibility of local recurrence with intraperitoneal seeding prior to lymph node involvement and a 20% risk of metastatic behavior.
  • In female patients with GCC of the appendix regardless of age, bilateral salpingo-oophorectomy is advocated.
  • In cases with obvious spread of the disease chemotherapy, mostly with 5-FU and leucovorin is advised.

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  • (PMID = 15967038.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1182398
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33. Greco L, Papa U: [Mucinous cystoadenocarcinoma of the appendix. A case report]. Ann Ital Chir; 2006 Jul-Aug;77(4):355-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Mucinous cystoadenocarcinoma of the appendix. A case report].
  • [Transliterated title] Il mucocele maligno dell'appendice vermiforme. Descrizione di un caso.
  • CASE REPORT: The Authors report a case of a 66-years-old male patient with mucinous cystoadenocarcinoma of the appendix.
  • Preoperative diagnosis was appendiceal mucocele.
  • At laparatomy was revealed the presence of a large mass of the appendix involving the caecum.
  • Hystology revealed diagnosis of mucinous cystoadenocarcinoma of the appendix.
  • After two weeks patient underwent right hemicolectomy, he is alive without disease at 36 months follow up.
  • Mucinous cystic neoplasms of the appendix is an uncommon disease that is rarely suspected before surgery.
  • The role of chemotherapy in the treatment of patients with appendiceal cancers remains controversial.
  • All patients with any form of appendiceal tumor appear to have an increased incidence of synchronous and metachronous neoplasms, especially in the gastrointestinal tract, and should be investigated and followed up appropriately.
  • [MeSH-major] Appendiceal Neoplasms. Cystadenocarcinoma, Mucinous

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  • (PMID = 17139968.001).
  • [ISSN] 0003-469X
  • [Journal-full-title] Annali italiani di chirurgia
  • [ISO-abbreviation] Ann Ital Chir
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
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34. Nishio R, Furuya Y, Akashi T, Okumura A, Fuse H: Primary adenocarcinoma of the appendix invading the urinary bladder. Int Urol Nephrol; 2006;38(3-4):481-2
MedlinePlus Health Information. consumer health - Bladder Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary adenocarcinoma of the appendix invading the urinary bladder.
  • We report a case of adenocarcinoma of the appendix invading the urinary bladder in a 75-year-old man.
  • Although cystoscopic examination and computed tomography suggested a primary or secondary bladder tumor, repeated transurethral bladder biopsy could not confirm the neoplasm.
  • At operation a primary neoplasm of the appendix invading the bladder was discovered and en bloc resection of the urinary bladder with the adherent cecum followed by an ileocolonic anastomosis and ureterocutaneostomy was performed.
  • [MeSH-major] Adenocarcinoma / pathology. Appendiceal Neoplasms / pathology. Urinary Bladder Neoplasms / pathology
  • [MeSH-minor] Aged. Fatal Outcome. Humans. Male. Neoplasm Invasiveness

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  • (PMID = 17160444.001).
  • [ISSN] 0301-1623
  • [Journal-full-title] International urology and nephrology
  • [ISO-abbreviation] Int Urol Nephrol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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35. Dupre MP, Jadavji I, Matshes E, Urbanski SJ: Diverticular disease of the vermiform appendix: a diagnostic clue to underlying appendiceal neoplasm. Hum Pathol; 2008 Dec;39(12):1823-6
MedlinePlus Health Information. consumer health - Carcinoid Tumors.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diverticular disease of the vermiform appendix: a diagnostic clue to underlying appendiceal neoplasm.
  • Acquired diverticula of the vermiform appendix are rare and arise as a result of different pathogenetic mechanisms.
  • One of the etiologies includes proximally located, often unsuspected small neoplasms.
  • Although the association of appendiceal diverticulosis and neoplasia is known, it remains underemphasized in the teaching and practice of surgical pathology.
  • To investigate the frequency of appendiceal neoplasms with acquired diverticulosis, we conducted a retrospective analysis of all appendectomy specimens received in our institution for a 55-month period (January 2002-July 2006).
  • Eleven (48%) appendectomy specimens with diverticulosis also harbored an appendiceal neoplasm.
  • The association of appendiceal neoplasms with diverticulosis was statistically significant (P < .0001, 2-sided Fisher exact test).
  • Neoplastic processes included 5 well-differentiated neuroendocrine tumors (carcinoids), 3 mucinous adenomas, 1 tubular adenoma, and 2 adenocarcinomas.
  • We stress the need for meticulous gross assessment with histologic examination of the entire appendectomy specimen in cases of appendiceal diverticulosis.
  • Thorough examination is required to rule out an underlying neoplasm as a cause of diverticulosis.
  • As acquired diverticula represent a rare finding, examination of the entire appendix in this setting does not create a significant impact on the workload within the pathologic laboratory.
  • [MeSH-major] Adenocarcinoma / pathology. Appendiceal Neoplasms / pathology. Appendix / pathology. Carcinoid Tumor / pathology. Cystadenoma, Mucinous / pathology. Diverticulum / pathology

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  • (PMID = 18715614.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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36. Tchana-Sato V, Detry O, Polus M, Thiry A, Detroz B, Maweja S, Hamoir E, Defechereux T, Coimbra C, De Roover A, Meurisse M, Honoré P: Carcinoid tumor of the appendix: a consecutive series from 1237 appendectomies. World J Gastroenterol; 2006 Nov 7;12(41):6699-701
ORBi (University of Liege). Free full Text at ORBi .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Carcinoid tumor of the appendix: a consecutive series from 1237 appendectomies.
  • AIM: To report the experience of the CHU Sart Tilman, University of Liege, Belgium, in the management of appendiceal carinoid tumor.
  • RESULTS: Among the 1237 appendectomies, 5 appendiceal carcinoid tumors were identified (0.4%) in 4 male and 1 female patients, with a mean age of 29.2 years (range: 6-82 years).
  • All tumors were located at the tip of the appendix with a mean diameter of 0.6 cm (range: 0.3-1.0 cm).
  • All patients were alive and disease-free during a mean follow-up of 33 mo.
  • CONCLUSION: Appendiceal carcinoid tumor most often presents as appendicitis.
  • In most cases, it is found incidentally during appendectomies and its diagnosis is rarely suspected before histological examination.
  • Appendiceal carcinoid tumor can be managed by simple appendectomy and resection of the mesoappendix, if its size is <or=1 cm.
  • [MeSH-major] Appendectomy / methods. Appendiceal Neoplasms / surgery. Carcinoid Tumor / surgery

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  • MedlinePlus Health Information. consumer health - Carcinoid Tumors.
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  • (PMID = 17075987.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 29
  • [Other-IDs] NLM/ PMC4125679
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37. Deschamps L, Couvelard A: Endocrine tumors of the appendix: a pathologic review. Arch Pathol Lab Med; 2010 Jun;134(6):871-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Endocrine tumors of the appendix: a pathologic review.
  • CONTEXT: Although rare, appendiceal endocrine tumors are the most common neoplasms of the appendix.
  • OBJECTIVE: To provide recent data that focus on the pathology of endocrine tumors of the appendix including classifications and guidelines for patient management.
  • CONCLUSIONS: Appendiceal endocrine tumors are separated into 2 main groups: classic endocrine tumors and goblet cell carcinoids.
  • Evaluation of their prognoses and risks of malignancy, according to these classifications, depends on several parameters including tumor size, proliferation rate, and infiltration of appendiceal wall and mesoappendix.
  • Most patients with classic endocrine tumors of the appendix have a favorable prognosis.
  • Indications for postappendectomy, complementary surgery, which are still controversial, especially for tumors between 1 and 2 cm, are presented and discussed.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Carcinoma, Neuroendocrine / pathology
  • [MeSH-minor] Appendectomy. Carcinoid Tumor / classification. Carcinoid Tumor / diagnosis. Carcinoid Tumor / pathology. Colectomy. Humans. Prognosis. World Health Organization

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  • (PMID = 20524865.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 41
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38. Paredes Esteban RM, Martínez de Vitoria JM, García Ruiz M: [An association of mucocele and carcinoid tumour of the appendix]. Cir Pediatr; 2006 Oct;19(4):250-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [An association of mucocele and carcinoid tumour of the appendix].
  • [Transliterated title] Un caso de asociación de mucocele y tumor carcinoide apendicular.
  • The carcinoid tumour of the appendix and the mucocele are entities rather infrequent in children and are normally diagnosed in the course of an appendicectomy that is, in most of the cases, curative.
  • The authors present a case of carcinoid tumour of the appendix associated to mucocele in a male, aged 10 patient, who underwent an appendicectomy by suspicion of an acute appendicitis.
  • The histologic study confirmed the presence of a mucocele of the appendix associated to a carcinoid tumour with a 0,7 cm diameter.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Carcinoid Tumor / pathology. Mucocele / pathology
  • [MeSH-minor] Appendectomy. Appendix / pathology. Appendix / surgery. Child. Humans. Male. Treatment Outcome

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  • (PMID = 17352118.001).
  • [ISSN] 0214-1221
  • [Journal-full-title] Cirugía pediátrica : organo oficial de la Sociedad Española de Cirugía Pediátrica
  • [ISO-abbreviation] Cir Pediatr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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39. Safioleas MC, Moulakakis KG, Kontzoglou K, Stamoulis J, Nikou GC, Toubanakis C, Lygidakis NJ: Carcinoid tumors of the appendix. Prognostic factors and evaluation of indications for right hemicolectomy. Hepatogastroenterology; 2005 Jan-Feb;52(61):123-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Carcinoid tumors of the appendix. Prognostic factors and evaluation of indications for right hemicolectomy.
  • BACKGROUND/AIMS: Carcinoid tumors of the appendix are thought to be the most common type of appendiceal neoplasms.
  • Although the vast majority of appendiceal carcinoids behave in a benign fashion, they are considered malignant because they all have the potential for invasion, metastasis and production of physiologically active substances.
  • Following confirmation of the diagnosis, secretion of 5-HLAA (5-Hydroxy-Inndole-Acetic Acid) was measured after a 24-hour collection of urine.
  • Also, patients with tumor size more than 1cm underwent a Somatostatin Receptor Scintigraphy (Octreoscan).
  • RESULTS: The most common site for the tumors was the tip of the appendix (18/22).
  • In the rest of the cases, the neoplasms were located in the base (4/22) and in the body (2/22), while in one patient the mesoappendix was invaded.
  • In sixteen patients the tumor size was less than 1cm, in seven patients the tumor diameter was measured to be 1 to 2cm and in one patient the tumor was 3cm.
  • Most of our patients (16/22) underwent only an appendicectomy, while in the rest of them (in the patients with tumor size between 1-2cm and in the patient with invasion of mesoappendix) a right hemicolectomy was performed.
  • No patient was found to have metastatic disease during the operation, while the patient with invasion of the mesoappendix developed metastases in the lung, two years after the operation.
  • CONCLUSIONS: Carcinoid tumors of the appendix, in most cases, are found incidentally during appendicectomies, especially in young females and usually are less than 1cm in size, which is probably the reason of the absence of metastases in all cases.
  • Histological examination and size of the tumor are important factors that contribute to the selection of the surgical treatment and both must be estimated by the surgeons to make the final choice.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Appendiceal Neoplasms / surgery. Carcinoid Tumor / pathology. Carcinoid Tumor / surgery

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  • (PMID = 15783011.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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40. Stinner B, Rothmund M: Neuroendocrine tumours (carcinoids) of the appendix. Best Pract Res Clin Gastroenterol; 2005 Oct;19(5):729-38
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Neuroendocrine tumours (carcinoids) of the appendix.
  • Neuroendocrine tumours (NETs) of the appendix (formerly 'carcinoids') are rare and are usually detected incidentally after appendectomy.
  • They are preferentially located at the tip of the appendix.
  • Treatment for lesions 1-2 cm is controversial and needs further characterization of the tumour (i.e. mesoappendiceal invasion, vascular invasion, mitotic activity, proliferation markers) and careful patient risk evaluation.
  • Overall prognosis of small appendiceal NET is excellent in all ages.
  • [MeSH-major] Appendectomy / methods. Appendiceal Neoplasms / pathology. Appendiceal Neoplasms / surgery. Carcinoid Tumor / pathology. Carcinoid Tumor / surgery. Neoplasm Invasiveness / pathology
  • [MeSH-minor] Adult. Age Distribution. Aged. Biopsy, Needle. Female. Follow-Up Studies. Humans. Immunohistochemistry. Incidence. Male. Middle Aged. Neoplasm Staging. Risk Assessment. Treatment Outcome

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  • (PMID = 16253897.001).
  • [ISSN] 1521-6918
  • [Journal-full-title] Best practice & research. Clinical gastroenterology
  • [ISO-abbreviation] Best Pract Res Clin Gastroenterol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 32
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41. Louthan O: [Neuroendocrine tumours of the appendix]. Vnitr Lek; 2009 Nov;55(11):1051-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Neuroendocrine tumours of the appendix].
  • According to WHO, neuroendocrine tumors of the appendix (appendiceal carcinoids) are defined as 1. well-differentiated endocrine tumors with benign or uncertain behavior, 2. well-differentiated endocrine carcinoma and 3. goblet cell carcinoma.
  • These tumors are usually diagnosed incidentally during appendectomy.
  • Carcinoid syndrome is rare in appendiceal carcinoid.
  • Tumor size greater than 2 cm is the most important parameter for prognosis.
  • Most patients are cured by appendectomy (appendiceal tumors < or = 2 cm), tumors with a diameter > 2 cm should be managed by right hemicolectomy.
  • [MeSH-major] Appendiceal Neoplasms. Neuroendocrine Tumors

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  • (PMID = 20017436.001).
  • [ISSN] 0042-773X
  • [Journal-full-title] Vnitr̆ní lékar̆ství
  • [ISO-abbreviation] Vnitr Lek
  • [Language] cze
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Czech Republic
  • [Number-of-references] 26
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42. Ruiz-Tovar J, Teruel DG, Castiñeiras VM, Dehesa AS, Quindós PL, Molina EM: Mucocele of the appendix. World J Surg; 2007 Mar;31(3):542-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mucocele of the appendix.
  • BACKGROUND: Mucocele of the appendix is an infrequent event, representing 0.3%-0.7% of appendiceal pathology and 8% of appendiceal tumors.
  • It is characterized by a located or diffuse distension of the appendix with a mucus-filled lumen.
  • MATERIALS AND METHODS: We describe 35 cases of mucocele of the appendix diagnosed at Ramón y Cajal Hospital between January 1985 and January 2006.
  • In 4 cases, mucocele coexisted with colorectal cancer and was an incidental finding during laparotomy performed for tumor resection.
  • Ultrasonography and computed tomography (CT) scan helped to achieve a correct diagnosis.
  • Preoperative diagnosis of mucocele was achieved in 29% of the cases; 88% of patients underwent appendectomy, 2 had ileocecal resection, and 2 others underwent right hemicolectomy.
  • We recommend follow-up of all patients with mucoceles, because sometimes they are associated with colorectal neoplasms and recurrence as pseudomyxoma peritonei.
  • [MeSH-major] Appendix. Mucocele / pathology. Mucocele / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Appendectomy. Appendiceal Neoplasms / diagnosis. Appendiceal Neoplasms / pathology. Appendiceal Neoplasms / surgery. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Treatment Outcome

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  • (PMID = 17318706.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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43. Cabanas J, Gomes da Silva R, Zappa L, Esquivel J, Cerruto C, Goldstein P, Sugarbaker PH: Splenic metastases from mucinous neoplasms of the appendix and colon. Tumori; 2006 Mar-Apr;92(2):104-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Splenic metastases from mucinous neoplasms of the appendix and colon.
  • AIMS AND BACKGROUND: Splenic metastases associated with mucinous intraabdominal tumors have been an enigma in the radiologic and oncology literature.
  • METHODS: Information on 9 patients who underwent splenectomy with intraparenchymal splenic masses associated with appendiceal or colorectal mucinous tumors with peritoneal dissemination was collected.
  • RESULTS: Eight of these patients had mucinous appendiceal tumors and 1 a mucinous sigmoid colon cancer.
  • These splenic tumor masses had a CT image compatible with metastases and not compatible with mucinous tumor layered out of the splenic capsule.
  • CONCLUSIONS: From our review of the clinical information available on these 9 patients, these splenic lesions were thought to be an entrapment of mucinous tumor within splenic surface trabeculae, which expand into the splenic parenchyma resembling metastatic disease.
  • [MeSH-major] Adenocarcinoma, Mucinous / secondary. Appendiceal Neoplasms / pathology. Colonic Neoplasms / pathology. Splenectomy. Splenic Neoplasms / secondary

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  • (PMID = 16724688.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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44. Smejkal P, Pazdro A, Smejkal M, Pafko P, Frantlová M: [The cystadenocarcinoma of the appendix]. Rozhl Chir; 2005 Jan;84(1):33-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [The cystadenocarcinoma of the appendix].
  • [Transliterated title] Kystadenokarcinom apendixu.
  • The authors present a case-review of a patient with a large retroperitoneal tumor.
  • Histology confirmed a mucous cystadenocarcinoma of the appendix.
  • This tumor is low-invasive, mucus producing and rarely metastazing.
  • During the tumor progression, the tumorous cells enter the peritoneal cavity and cause, so called, pseudomyxoma peritonei.
  • The treatment principle is to complete a radical surgical removal of the tumor and, furthermore, in case of the pseudomyxoma periotenei, also application of the local peroperative chemotherapy.
  • [MeSH-major] Appendiceal Neoplasms. Cystadenocarcinoma, Mucinous

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  • (PMID = 15813454.001).
  • [ISSN] 0035-9351
  • [Journal-full-title] Rozhledy v chirurgii : měsíčník Československé chirurgické společnosti
  • [ISO-abbreviation] Rozhl Chir
  • [Language] cze
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Czech Republic
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45. Echenique-Elizondo M, Liron de Robles C, Amondarain Arratíbel JA, Aribe X: [Mucocele of the appendix]. Cir Esp; 2007 Nov;82(5):297-300

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Mucocele of the appendix].
  • [Transliterated title] Mucoceles apendiculares.
  • INTRODUCTION: Mucoceles of the appendix are infrequent entities and are found in only 0.25% of all appendectomies and 8% of all appendicular tumors.
  • MATERIAL AND METHODS: We describe 27 cases of mucocele of the appendix treated at Donostia Hospital between January 1978 and December 2006.
  • Three patients (11.1%) underwent surgery because of a diagnosis of abdominal tumor.
  • The main reason for emergency surgery was lower right abdominal pain in 14 patients (82.2%), intestinal obstruction in one (5.8%), a diagnosis of endometriosis in one (5.8%) and a diagnosis of pyosalpinx in one (5.8%).
  • We found an overall incidence of 11 cases (40.7%) presenting with synchronous or metachronous neoplasms from other locations.
  • CONCLUSIONS: We recommend monitoring of all patients with mucocele of the appendix, because these masses can sometimes be associated with neoplasms in other locations and there is a risk of pseudomyxoma peritonei even after a long follow-up.
  • [MeSH-major] Appendix. Cecal Diseases / surgery. Mucocele / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Appendiceal Neoplasms / diagnosis. Cystadenoma, Mucinous / diagnosis. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Pseudomyxoma Peritonei / diagnosis. Radiography, Abdominal. Tomography, X-Ray Computed

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  • (PMID = 18021629.001).
  • [ISSN] 0009-739X
  • [Journal-full-title] Cirugía española
  • [ISO-abbreviation] Cir Esp
  • [Language] spa
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Spain
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46. Buntrock M, Manncke K: [Free mobile intra-abdominal "tumor"]. Chirurg; 2010 Feb;81(2):148-50

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Free mobile intra-abdominal "tumor"].
  • [Transliterated title] Frei beweglicher "Tumor" im Abdomen.
  • The rare condition of an accidentally discovered 3 cm sized tumor in the abdomen is reported which was completely free and migrating within the abdominal cavity.
  • Surprisingly the tumor was localized at different sites.
  • Histopathology revealed that it was most probably a calcified appendix epiploicum separated from the colon.
  • [MeSH-major] Abdominal Neoplasms / diagnosis. Abdominal Neoplasms / surgery. Colon
  • [MeSH-minor] Diagnosis, Differential. Humans. Laparoscopy. Male. Middle Aged. Patient Care Team. Tomography, X-Ray Computed. Ultrasonography

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  • (PMID = 19760376.001).
  • [ISSN] 1433-0385
  • [Journal-full-title] Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen
  • [ISO-abbreviation] Chirurg
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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47. San Vicente B, Bardají C, Rigol S, Obiols P, Melo M, Bella R: [Retrospective evaluation of carcinoid tumors of the appendix in children]. Cir Pediatr; 2009 Apr;22(2):97-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Retrospective evaluation of carcinoid tumors of the appendix in children].
  • [Transliterated title] Estudio retrospectivo del tumor carcinoide apendicular en niños.
  • Carcinoids of the appendix are rare in children.
  • To investigate the significance of the diagnosis of appendiceal carcinoid tumors in children, we conducted a retrospective study in our institution.
  • In four patients the diagnosis was appendiceal carcinoid.
  • The median tumor diameter was lower than 1 cm and the appropriate treatment was appendectomy.
  • [MeSH-major] Appendix. Carcinoid Tumor. Cecal Neoplasms

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  • (PMID = 19715134.001).
  • [ISSN] 0214-1221
  • [Journal-full-title] Cirugía pediátrica : organo oficial de la Sociedad Española de Cirugía Pediátrica
  • [ISO-abbreviation] Cir Pediatr
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 14
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48. Palanivelu C, Rangarajan M, Annapoorni S, Senthilkumar R, Anand NV: Laparoscopic right hemicolectomy for goblet-cell carcinoid of the appendix: report of a rare case and literature survey. J Laparoendosc Adv Surg Tech A; 2008 Jun;18(3):417-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Laparoscopic right hemicolectomy for goblet-cell carcinoid of the appendix: report of a rare case and literature survey.
  • Tumors of the appendix are rare entities, and the majority of them are discovered accidentally during an investigation for other conditions.
  • Laparoscopic surgery for appendiceal goblet-cell carcinoid (GCC) has only been reported once before.
  • Our patient was incidentally discovered to have an appendiceal tumor and was referred to us for laparoscopy.
  • The tumor involved the body of the appendix and was adherent to the cecum.
  • Histopathology confirmed an appendiceal goblet-cell carcinoid.
  • GCC is a rare tumor of the appendix.
  • Hemicolectomy is indicated in specific situations, such as local involvement or tumor size >2 cm.
  • In our patient, the tumor was adherent to the cecum and tumor size was 5 cm.
  • Laparoscopic surgery for appendiceal tumors is safe, feasible, and even may be beneficial.
  • [MeSH-major] Carcinoid Tumor / surgery. Colectomy
  • [MeSH-minor] Aged. Appendiceal Neoplasms / pathology. Appendiceal Neoplasms / surgery. Humans. Laparoscopy. Male

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  • (PMID = 18503377.001).
  • [ISSN] 1092-6429
  • [Journal-full-title] Journal of laparoendoscopic & advanced surgical techniques. Part A
  • [ISO-abbreviation] J Laparoendosc Adv Surg Tech A
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 18
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49. Rossi G, Nannini N, Bertolini F, Mengoli MC, Fano R, Cavazza A: Clear cell carcinoid of the appendix: an uncommon variant of lipid-rich neuroendocrine tumor with a broad differential diagnosis. Endocr Pathol; 2010 Dec;21(4):258-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clear cell carcinoid of the appendix: an uncommon variant of lipid-rich neuroendocrine tumor with a broad differential diagnosis.
  • The designation of clear cell/lipid-rich refers to an unusual variant of neuroendocrine tumor ("carcinoid") described in several organs, but only recently observed in the appendix.
  • In this study, we report the morphologic, immunohistochemical, and ultrastructural features of an incidentally discovered appendiceal clear cell/lipid-rich carcinoid in a 32-year-old man without any evidence of von Hippel-Lindau disease.
  • Differential diagnosis with mimicking neoplastic and non-tumor lesions, epidemiology, and clinical behavior of this exceedingly rare variant of carcinoid of the appendix are also discussed.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Carcinoid Tumor / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Diagnosis, Differential. Humans. Immunohistochemistry. Male. Microscopy, Electron, Transmission

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  • (PMID = 20814762.001).
  • [ISSN] 1559-0097
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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50. McGory ML, Maggard MA, Kang H, O'Connell JB, Ko CY: Malignancies of the appendix: beyond case series reports. Dis Colon Rectum; 2005 Dec;48(12):2264-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignancies of the appendix: beyond case series reports.
  • PURPOSE: A comprehensive analysis was performed for five histologic types of appendiceal tumors to compare incidence, clinicopathologic features, survival, and appropriateness of surgery.
  • The appropriateness of the operative procedure (i.e. , appendectomy vs. colectomy) was examined by tumor type and size.
  • RESULTS: Tumor incidence, patient demographics, survival outcomes, and appropriateness of surgery varied significantly among the different appendiceal tumor histologies.
  • The most common appendiceal tumors were mucinous.
  • Although current guidelines specify that a right hemicolectomy (rather than an appendectomy) be performed for all noncarcinoid tumors and carcinoid tumors >2 cm, we found that 30 percent of noncarcinoids underwent appendectomy.
  • CONCLUSIONS: This study provides a population-based analysis of epidemiology, tumor characteristics, survival, and quality of care for appendiceal carcinomas.
  • This characterization provides a novel description of the presentation and outcomes for malignancies of the appendix and highlights that a substantial number of patients with appendiceal tumors may not be receiving appropriate surgical resection.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Appendiceal Neoplasms / pathology. Carcinoid Tumor / pathology. Carcinoma, Signet Ring Cell / pathology

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  • (PMID = 16258711.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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51. Kitagawa M, Kotani T, Yamano T, Tsurudome H, Hatakeyama T, Kuriu Y, Nishi H, Yabe M: Secondary torsion of vermiform appendix with mucinous cystadenoma. Case Rep Gastroenterol; 2007;1(1):32-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Secondary torsion of vermiform appendix with mucinous cystadenoma.
  • Torsion of the vermiform appendix is a rare disorder, which causes abdominal symptoms indistinguishable from acute appendicitis.
  • We report a case (a 34-year-old male) of secondary torsion of the vermiform appendix with mucinous cystadenoma.
  • This case was characterized by mild inflammatory responses, pentazocine-resistant abdominal pain, and appendiceal tumor, which was not enhanced by the contrast medium on computed tomography presumably because of reduced blood flow by the torsion.
  • These findings may be helpful for the preoperative diagnosis of secondary appendiceal torsion.

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  • [Cites] Med J Aust. 2002 Dec 2-16;177(11-12):632 [12523322.001]
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  • (PMID = 21487469.001).
  • [ISSN] 1662-0631
  • [Journal-full-title] Case reports in gastroenterology
  • [ISO-abbreviation] Case Rep Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Other-IDs] NLM/ PMC3073785
  • [Keywords] NOTNLM ; Appendix / Mucinous cystadenoma / Torsion
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52. Alsaad KO, Serra S, Chetty R: Combined goblet cell carcinoid and mucinous cystadenoma of the vermiform appendix. World J Gastroenterol; 2009 Jul 21;15(27):3431-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Combined goblet cell carcinoid and mucinous cystadenoma of the vermiform appendix.
  • Goblet cell carcinoid is an uncommon primary tumor of the vermiform appendix, characterized by dual endocrine and glandular differentiation.
  • Whether goblet cell carcinoid represents a morphological variant of appendiceal classical carcinoid or a mucin-producing adenocarcinoma is a matter of conjecture.
  • Rare cases of goblet cell carcinoid with other concomitant appendiceal epithelial neoplasms have been documented.
  • In this report, we describe a rare case of combined appendiceal goblet cell carcinoid and mucinous cystadenoma, and discuss the possible histopathogenesis of this combination.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Appendix / pathology. Carcinoid Tumor / pathology. Cystadenoma, Mucinous / pathology
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Female. Humans. Middle Aged

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  • [Cites] Arch Pathol Lab Med. 2001 Mar;125(3):386-90 [11231488.001]
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  • (PMID = 19610147.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC2712907
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53. Smakal O, Hartmann I, Grepl M, Michálková K: [Testicular appendix torsion can mimic a tumour of the paratesticular tissues]. Aktuelle Urol; 2010 Mar;41(2):134-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Testicular appendix torsion can mimic a tumour of the paratesticular tissues].
  • [Transliterated title] Die Hydatidentorsion kann einen Tumor des paratestikulären Gewebes vortäuschen.
  • The authors present a case of testicular appendix torsion that mimicked a tumour of the paratesticular tissues due its calm clinical course, objective palpation and ultrasound finding.
  • The torsion of the big testicular appendix was found during surgery from an inguinal approach.
  • The histological examination confirmed only minimal inflammation changes and excluded tumour disease.
  • [MeSH-major] Cysts / diagnosis. Testicular Diseases / diagnosis. Testicular Neoplasms / diagnosis. Torsion Abnormality / diagnosis
  • [MeSH-minor] Child. Diagnosis, Differential. Humans. Male. Ultrasonography, Doppler

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  • [Copyright] Georg Thieme Verlag Stuttgart New York.
  • (PMID = 20183791.001).
  • [ISSN] 1438-8820
  • [Journal-full-title] Aktuelle Urologie
  • [ISO-abbreviation] Aktuelle Urol
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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54. Umemoto M, Shiota M, Shimaoka M, Hoshiai H: Definitive diagnosis of primary adenocarcinoma of the appendix by laparoscopic appendectomy. J Obstet Gynaecol Res; 2007 Aug;33(4):590-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Definitive diagnosis of primary adenocarcinoma of the appendix by laparoscopic appendectomy.
  • We report a 62-year-old woman with a primary adenocarcinoma of the appendix mimicking ovarian tumor.
  • However, the present case suggests that, in some cases, if cancer of the appendix can be diagnosed early, laparotomy can be avoided and the cancer treated with minimally invasive laparoscopic surgery alone.
  • [MeSH-major] Adenocarcinoma / pathology. Appendiceal Neoplasms / pathology

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  • (PMID = 17688638.001).
  • [ISSN] 1341-8076
  • [Journal-full-title] The journal of obstetrics and gynaecology research
  • [ISO-abbreviation] J. Obstet. Gynaecol. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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55. Toyomasu Y, Tsutsumi S, Yamaguchi S, Mochiki E, Asao T, Kuwano H: Laparoscopy-assisted ileocecal resection for mucosa-associated lymphoid tissue lymphoma of the appendix: case report. Hepatogastroenterology; 2009 Jul-Aug;56(93):1078-81
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  • [Title] Laparoscopy-assisted ileocecal resection for mucosa-associated lymphoid tissue lymphoma of the appendix: case report.
  • A 74-year-old female had repeated relapses of right lower abdominal pain; a colonoscopic examination showed a submucosal tumor of the appendix.
  • Under provisional diagnosis of appendicitis caused by a submucosal tumor, a laparoscopic operation was performed.
  • The laparoscopic observation did not reveal the typical finding of appendicitis.
  • The tumor was thought to be a malignant neoplasm.
  • The ileocecal region was excised with lymph node dissection.
  • Macroscopically, the mass was localized in the appendix and did not infiltrate to the cecum.
  • Immunohistochemically, the tumor cells were positive for CD20 and CD79a and negative for CD3, CD10, and cyclin D1.
  • The histological diagnosis was mucosa-associated lymphoid tissue (MALT) lymphoma of the appendix.
  • Furthermore, very few cases of the appendiceal MALT lymphoma have been reported.
  • The laparoscopy was used in the case of a patient diagnosed with appendicitis and considered the possibility of MALT lymphoma of the appendix.
  • We then performed an ileocecal resection, which is considered radical surgery.
  • The present case suggests that a laparoscopic observation is helpful for the appropriate diagnosis and therapy of MALT lymphoma of the appendix.
  • [MeSH-major] Appendiceal Neoplasms / surgery. Laparoscopy. Lymphoma, B-Cell, Marginal Zone / surgery
  • [MeSH-minor] Aged. Cecum / pathology. Cecum / surgery. Colonography, Computed Tomographic. Colonoscopy. Diagnosis, Differential. Female. Humans. Ileum / pathology. Ileum / surgery. Lymph Node Excision

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  • (PMID = 19760945.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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56. Parker WT, Harper JG, Rivera DE, Holsten SB, Bowden T: Mesenteric cavernous hemangioma involving small bowel and appendix: a rare presentation of a vascular tumor. Am Surg; 2009 Sep;75(9):811-6
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  • [Title] Mesenteric cavernous hemangioma involving small bowel and appendix: a rare presentation of a vascular tumor.
  • Complete workup was performed to localize primary source of abdominal mass and eventual open biopsy was planned resulting in en bloc resection of the mass, which had invaded the terminal ileum and appendix.
  • Final pathologic diagnosis was cavernous mesenteric hemangioma.
  • Diagnosis of cavernous mesenteric hemangioma is difficult and multiple imaging modalities can prove inconclusive.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Hemangioma, Cavernous / pathology. Ileal Neoplasms / pathology
  • [MeSH-minor] Adult. Angiography. Biopsy. Diagnosis, Differential. Humans. Laparotomy. Magnetic Resonance Imaging. Male. Mesenteric Arteries / pathology. Mesenteric Arteries / radiography. Tomography, X-Ray Computed

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  • (PMID = 19774953.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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57. Ng SC, Noursadeghi M, von Herbay A, Vaizey C, Pitcher MC, Flanagan KL: Cytomegalovirus ileitis associated with goblet cell carcinoid tumour of the appendix. J Infect; 2007 Mar;54(3):e153-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytomegalovirus ileitis associated with goblet cell carcinoid tumour of the appendix.
  • We report a female patient with cytomegalovirus (CMV) terminal ileitis and CMV viraemia, associated with a metastatic goblet cell carcinoid (GCC) tumour of the appendix.
  • [MeSH-major] Appendiceal Neoplasms / complications. Carcinoid Tumor / complications. Cytomegalovirus / isolation & purification. Cytomegalovirus Infections / complications. Ileitis / complications. Ileitis / virology

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  • (PMID = 17049463.001).
  • [ISSN] 1532-2742
  • [Journal-full-title] The Journal of infection
  • [ISO-abbreviation] J. Infect.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antiviral Agents; P9G3CKZ4P5 / Ganciclovir
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58. Mukensnabl P, Michal M, Hadravská S: [Carcinoids of the appendix]. Rozhl Chir; 2005 Apr;84(4):197-200
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Carcinoids of the appendix].
  • [Transliterated title] Karcinoidy apendixu.
  • The appendical carcinoids represent a heterogeneous group of tumors of different morphology, biological features and treatment.
  • Our study aims to inform clinical practitioners, mainly surgeons and oncologists, about individual types of the appendical carcinoids, which are considered the most frequent carcinoid tumors the clinical practitioners come into contact with at all levels of the hospital care.
  • Our work describes the types of the appendical tumors from the histological point of view, as well as from the prognostic and therapeutical points of view.
  • [MeSH-major] Carcinoid Tumor
  • [MeSH-minor] Appendiceal Neoplasms / diagnosis. Appendiceal Neoplasms / pathology. Appendiceal Neoplasms / surgery

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  • (PMID = 15984148.001).
  • [ISSN] 0035-9351
  • [Journal-full-title] Rozhledy v chirurgii : měsíčník Československé chirurgické společnosti
  • [ISO-abbreviation] Rozhl Chir
  • [Language] cze
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Czech Republic
  • [Number-of-references] 8
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59. Sierra-Montenegro E, Sierra-Luzuriaga G, Leone-Stay G, Quiñonez-Auria C, Salazar-Menéndez V: Mucinous cystadenoma of the appendix. Case report. Cir Cir; 2010 May-Jun;78(3):255-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mucinous cystadenoma of the appendix. Case report.
  • BACKGROUND: Pathology of the appendix represents >50% of surgical activity.
  • The objective of this study is to report on a case of mucinous cystadenoma of the appendix.
  • The current problem evolved 1 year ago during control studies for his disease.
  • Computed tomography (CT) of the abdomen was done, demonstrating a tumor in the right iliac fossa.
  • Colonoscopy confirmed a tumor with smooth edges located in the cecum.
  • Surgery was recommended with a diagnosis of lipoma of the cecum.
  • During surgery, a large tumor was found, indicating a poor prognosis.
  • Mucinous cystadenoma is the most common form of mucocele of the appendix.
  • Diagnostic protocols are the same for benign appendix pathology.
  • Mucoceles of the appendix are pathologies with a favorable prognosis when appropriate treatment is done.
  • [MeSH-major] Appendix. Cecal Neoplasms. Cystadenoma, Mucinous

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  • (PMID = 20642910.001).
  • [ISSN] 0009-7411
  • [Journal-full-title] Cirugía y cirujanos
  • [ISO-abbreviation] Cir Cir
  • [Language] eng; spa
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Mexico
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60. Yantiss RK, Panczykowski A, Misdraji J, Hahn HP, Odze RD, Rennert H, Chen YT: A comprehensive study of nondysplastic and dysplastic serrated polyps of the vermiform appendix. Am J Surg Pathol; 2007 Nov;31(11):1742-53
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  • [Title] A comprehensive study of nondysplastic and dysplastic serrated polyps of the vermiform appendix.
  • Although similar lesions occur in the appendix, they have never been systematically investigated.
  • We evaluated a study group of 56 serrated polyps, a control group of 17 mucinous cystadenomas, and 4 adenocarcinomas with adjacent serrated polyps of the appendix to better understand their pathogenesis.
  • We conclude that molecular features of the "serrated neoplastic pathway" are present with similar frequencies among dysplastic and nondysplastic serrated appendiceal polyps and are not highly prevalent in adjacent carcinomas.
  • These features, including BRAF mutations, may be more closely related to a serrated morphology in appendiceal polyps rather than biologically important changes.
  • [MeSH-major] Adenocarcinoma / pathology. Adenomatous Polyps / pathology. Appendix / pathology. Cecal Neoplasms / pathology. Cell Transformation, Neoplastic / pathology. Cystadenoma, Mucinous / pathology
  • [MeSH-minor] Adaptor Proteins, Signal Transducing / analysis. Adult. Aged. Aged, 80 and over. Cell Proliferation. DNA Modification Methylases / analysis. DNA Repair Enzymes / analysis. Female. Gene Expression Regulation. Humans. Ki-67 Antigen / analysis. Male. Microsatellite Instability. Middle Aged. Mucous Membrane / pathology. MutS Homolog 2 Protein / analysis. Mutation. Neoplasm Invasiveness. Nuclear Proteins / analysis. Proto-Oncogene Proteins / genetics. Proto-Oncogene Proteins B-raf / genetics. Retrospective Studies. Tumor Suppressor Protein p53 / analysis. Tumor Suppressor Proteins / analysis. beta Catenin / analysis. beta Catenin / genetics. ras Proteins / genetics

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  • [ErratumIn] Am J Surg Pathol. 2008 Jan;32(1):175. Hahn, Hejin P [added]
  • (PMID = 18059232.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / CTNNB1 protein, human; 0 / KRAS protein, human; 0 / Ki-67 Antigen; 0 / MLH1 protein, human; 0 / Nuclear Proteins; 0 / Proto-Oncogene Proteins; 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53; 0 / Tumor Suppressor Proteins; 0 / beta Catenin; EC 2.1.1.- / DNA Modification Methylases; EC 2.1.1.63 / MGMT protein, human; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf; EC 3.6.1.3 / MSH2 protein, human; EC 3.6.1.3 / MutS Homolog 2 Protein; EC 3.6.5.2 / ras Proteins; EC 6.5.1.- / DNA Repair Enzymes
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61. Butte JM, García-Huidobro MA, Torres J, Duarte I, Zúñiga A, Llanos O: [Long-term survival in carcinoid tumour of the appendix. An analysis of 8903 appendectomies]. Gastroenterol Hepatol; 2009 Oct;32(8):537-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Long-term survival in carcinoid tumour of the appendix. An analysis of 8903 appendectomies].
  • [Transliterated title] Evaluación de la sobrevida a largo plazo del carcinoide del apéndice cecal. Un análisis a partir de 8.903 apendicectomías.
  • INTRODUCTION: Appendiceal carcinoids are the most frequent tumors of the appendix and are usually detected as an incidental finding in the final pathology report.
  • The aim of this study was to evaluate the clinical and pathological characteristics, surgical treatment and long-term survival in patients with an appendiceal carcinoid tumor.
  • MATERIAL AND METHODS: We performed a retrospective study of patients treated from 1980 to 2007 with a pathological diagnosis of appendiceal carcinoid tumor.
  • Carcinoid tumor was diagnosed in 40 patients (25 women and 15 men), aged 37+/-18 years old.
  • The appendectomy was performed for appendicitis in 33 of these patients, and the final pathology report confirmed the diagnosis in 24.
  • The tumor was localized in the distal third of the appendix in 24 patients (60%), and the size of the tumor was less than 1cm in 28 (70%).
  • Twenty-nine (72.5%) of these tumors infiltrated the subserosal and/or the serosal layer.
  • CONCLUSIONS: Appendiceal carcinoid tumor is usually detected incidentally in the pathological analysis in patients undergoing surgery for suspected appendicitis.
  • [MeSH-major] Appendectomy. Appendiceal Neoplasms / mortality. Appendiceal Neoplasms / surgery. Carcinoid Tumor / mortality. Carcinoid Tumor / surgery

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  • (PMID = 19616872.001).
  • [ISSN] 0210-5705
  • [Journal-full-title] Gastroenterología y hepatología
  • [ISO-abbreviation] Gastroenterol Hepatol
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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62. Iwańczak B, Stawarski A, Czernik J, Bronowickip K, Iwańczak F, Pytrus T, Klempous J, Godziński J: [Diagnostic difficulties in pediatric abdominal pain with potential appendicitis]. Przegl Lek; 2007;64 Suppl 3:56-60
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  • [Transliterated title] Trudności diagnostyczne przyczyn bólów brzucha okolicy wyrostka robaczkowego u dzieci.
  • RESULTS: The most often Crohn's disease were recognized (9 children), in 2 cases with concomitant other pathologies (fecal tumor of appendix in one case and with peritoneal abscess after perforation of intestinal wall).
  • In one boy with ulcerative colitis, during exacerbation of the disease appendicitis complicated by rupture and peritonitis was observed.
  • Carcinoid of the appendix was the cause of abdominal pain in one child.
  • 3. All children with periappendipected of Crohn's disease.
  • 4. All children with equivocal presentations of appendicitis and with normal appendix during operation should undergo further diagnostic evaluation.
  • [MeSH-major] Abdominal Pain / etiology. Appendicitis / diagnosis
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Diagnosis, Differential. Female. Humans. Infant. Male

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  • (PMID = 18431916.001).
  • [ISSN] 0033-2240
  • [Journal-full-title] Przegla̧d lekarski
  • [ISO-abbreviation] Prz. Lek.
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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63. Delfosse V, Dome F, Detrembleur N, Wetz P, Boniver J, Fridman V: [Neuroendocrine tumors of the appendix]. Rev Med Liege; 2009 Jul-Aug;64(7-8):361-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Neuroendocrine tumors of the appendix].
  • [Transliterated title] Tumeurs neuroendocrines appendiculaires: à propos d'un cas, de l'histologie à la thérapeutique.
  • The histological study of the appendix revealed a tubular variant of endocrine carcinoma of the appendix.
  • Neuroendocrine tumors ("NETs") of the appendix are rare tumors which are usually detected incidentally, affecting 0.3% to 0.9% of appendectomies.
  • Depending on their size, but also on some other factors, including histologic type, these tumors will require specific treatment; sometimes appendectomy will not be sufficient.
  • [MeSH-major] Appendectomy. Appendiceal Neoplasms / pathology. Appendiceal Neoplasms / surgery. Carcinoma, Neuroendocrine / pathology. Carcinoma, Neuroendocrine / surgery
  • [MeSH-minor] Appendicitis / etiology. Appendicitis / pathology. Appendicitis / surgery. Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Neuroendocrine Tumors / pathology. Neuroendocrine Tumors / surgery. Prognosis. Treatment Outcome. Young Adult

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  • (PMID = 19777911.001).
  • [ISSN] 0370-629X
  • [Journal-full-title] Revue médicale de Liège
  • [ISO-abbreviation] Rev Med Liege
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Belgium
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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64. Logan-Collins JM, Lowy AM, Robinson-Smith TM, Kumar S, Sussman JJ, James LE, Ahmad SA: VEGF expression predicts survival in patients with peritoneal surface metastases from mucinous adenocarcinoma of the appendix and colon. Ann Surg Oncol; 2008 Mar;15(3):738-44
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  • [Title] VEGF expression predicts survival in patients with peritoneal surface metastases from mucinous adenocarcinoma of the appendix and colon.
  • Patients with mucinous adenocarcinomas metastatic to the peritoneal surfaces can be treated with cytoreductive surgery, and both tumor grade and cytoreduction status are prognostic.
  • We hypothesized that angiogenic indices may be prognostic in patients undergoing cytoreductive surgery for mucinous adenocarcinoma of the appendix and colon.
  • RESULTS: A total of 26 males and 9 females, with a mean age of 50 years, underwent cytoreductive surgery and IPHP for mucinous adenocarcinoma of appendiceal (n = 32) or colonic (n = 3) origin.
  • With a mean follow-up of 18 months (range 1-63 months), 23 had disease recurrence and 12 were alive without recurrence.
  • CONCLUSIONS: These results suggest that markers of tumor angiogenesis may predict survival in patients with peritoneal surface metastases from mucinous adenocarcinoma.
  • These findings provoke the hypothesis that antiangiogenic therapies may be effective in patients with this devastating disease.
  • [MeSH-major] Adenocarcinoma, Mucinous / metabolism. Adenocarcinoma, Mucinous / therapy. Appendiceal Neoplasms / pathology. Appendiceal Neoplasms / therapy. Biomarkers, Tumor / biosynthesis. Peritoneal Neoplasms / metabolism. Peritoneal Neoplasms / therapy. Vascular Endothelial Growth Factor A / biosynthesis

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  • (PMID = 18043973.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A
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65. Ahmad J, Andrabi SI, Thekkinkattil DK, Rathore MA: Adenocarcinoid tumour of the appendix masquerading as acute appendicitis: a word of caution. Ulus Travma Acil Cerrahi Derg; 2008 Apr;14(2):167-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenocarcinoid tumour of the appendix masquerading as acute appendicitis: a word of caution.
  • Adenocarcinoids are rare and aggressive tumors with histological features of both carcinoid tumor and adenocarcinoma.
  • We report a case of a 32-year-old man with diffuse infiltration of the appendix wall and mesoappendix by an adenocarcinoid.
  • We suggest that patients with diffuse appendiceal involvement require an aggressive surgical therapy and follow-up.
  • [MeSH-major] Appendiceal Neoplasms / diagnosis. Carcinoid Tumor / diagnosis
  • [MeSH-minor] Adult. Appendicitis / diagnosis. Diagnosis, Differential. Humans. Male. Tomography, X-Ray Computed

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  • (PMID = 18523911.001).
  • [ISSN] 1306-696X
  • [Journal-full-title] Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES
  • [ISO-abbreviation] Ulus Travma Acil Cerrahi Derg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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66. Nakamura S, Kimura S, Kashima M, Shichijo K, Yoshida S, Harada E, Matsushita T, Oshima Y, Tamaki Y, Horiuchi N, Takeichi T, Fujimoto H, Masuda K, Iwasaka N, Shinomiya S: [A case of peritonitis carcinomatosa from goblet cell carcinoid of the appendix treated by intraperitoneal paclitaxel and systemic S-1 chemotherapy]. Gan To Kagaku Ryoho; 2008 Dec;35(13):2425-8
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  • [Title] [A case of peritonitis carcinomatosa from goblet cell carcinoid of the appendix treated by intraperitoneal paclitaxel and systemic S-1 chemotherapy].
  • Goblet cell carcinoid of the appendix is a rare neoplasm and clinically tends to take a malignant course.
  • Abdominal computed tomography showed massive ascites and slight contrast enhancement of appendix.
  • A tumor was found by colonoscopic examination at the orifice of vermiform and was diagnosed pathologically as goblet cell carcinoid of the appendix.
  • We performed intraperitoneal paclitaxel(PTX)administration at 70 mg/m(2) week without any resection of the tumor.
  • For about one year, her tumor was controlled but became worse thirteen months after diagnosis and died.
  • It is thought that intraabdominal paclitaxel administration and systemic S-1 therapy can be one of appropriate forms of chemotherapy for inoperable peritoneal carcinomatosis from goblet cell carcinoid of appendix.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoid Tumor / drug therapy. Carcinoid Tumor / pathology. Oxonic Acid / therapeutic use. Paclitaxel / therapeutic use. Peritonitis / drug therapy. Peritonitis / pathology. Tegafur / therapeutic use
  • [MeSH-minor] Aged. Colonic Neoplasms / complications. Colonic Neoplasms / drug therapy. Colonic Neoplasms / pathology. Colonic Neoplasms / surgery. Colonoscopy. Drug Combinations. Female. Humans. Injections, Intraperitoneal. Tomography, X-Ray Computed. Treatment Failure

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  • (PMID = 19098416.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Drug Combinations; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid; P88XT4IS4D / Paclitaxel
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67. Topkan E, Polat Y, Karaoglu A: Primary mucinous adenocarcinoma of appendix treated with chemotherapy and radiotherapy: a case report. Tumori; 2008 Jul-Aug;94(4):596-9
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  • [Title] Primary mucinous adenocarcinoma of appendix treated with chemotherapy and radiotherapy: a case report.
  • A rare case of primary appendiceal mucinous adenocarcinoma is reported.
  • An appendectomy was performed resulting in a histological diagnosis of grade 2 mucinous adenocarcinoma of the appendix.
  • Two of the 17 resected lymph nodes were tumor positive but there was no residual tumor in the hemicolectomy specimen.
  • Three cycles of capecitabine 1250 mg/m2 on days 1-14 and oxaliplatin 130 mg/m2 on day 1, every 21 days (CAPOX) were administered, then a total dose of 50.4 Gy external-beam radiation therapy was delivered to the primary tumor region and 45 Gy to the lymphatics, and finally 3 further cycles of the CAPOX regimen were administered.
  • Multimodality treatment was well tolerated by the patient, who is still alive 25 months after the hemicolectomy procedure with no evidence of disease progression.
  • [MeSH-major] Adenocarcinoma, Mucinous / drug therapy. Adenocarcinoma, Mucinous / radiotherapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Appendiceal Neoplasms / drug therapy. Appendiceal Neoplasms / radiotherapy. Colectomy
  • [MeSH-minor] Capecitabine. Chemotherapy, Adjuvant. Deoxycytidine / administration & dosage. Deoxycytidine / analogs & derivatives. Drug Administration Schedule. Fluorouracil / administration & dosage. Fluorouracil / analogs & derivatives. Humans. Lymph Node Excision. Male. Middle Aged. Neoplasm Staging. Organoplatinum Compounds / administration & dosage. Radiotherapy, Adjuvant. Treatment Outcome

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  • (PMID = 18822701.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; 04ZR38536J / oxaliplatin; 0W860991D6 / Deoxycytidine; 6804DJ8Z9U / Capecitabine; U3P01618RT / Fluorouracil
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68. Mukhopadhyay M, Shukla RM, Mandal KC, Mukhopadhyay B: Renal teratoma with duplication of cecum and appendix. J Pediatr Surg; 2010 Jan;45(1):255-8
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  • [Title] Renal teratoma with duplication of cecum and appendix.
  • The tumor was removed successfully, and the patient had an uneventful recovery.
  • The tumor mass also had an appendix and cecum within the tumor, along with a normal appendix and cecum with a separate blood supply.
  • [MeSH-major] Appendix / abnormalities. Cecum / abnormalities
  • [MeSH-minor] Humans. Infant. Kidney / pathology. Kidney / radiography. Kidney Neoplasms / pathology. Kidney Neoplasms / radiography. Kidney Neoplasms / surgery. Male. Teratoma / pathology. Teratoma / radiography. Teratoma / surgery. Tomography, X-Ray Computed

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20105615.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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69. Agaimy A, Pelz AF, Wieacker P, Roessner A, Wünsch PH, Schneider-Stock R: Gastrointestinal stromal tumors of the vermiform appendix: clinicopathologic, immunohistochemical, and molecular study of 2 cases with literature review. Hum Pathol; 2008 Aug;39(8):1252-7
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  • [Title] Gastrointestinal stromal tumors of the vermiform appendix: clinicopathologic, immunohistochemical, and molecular study of 2 cases with literature review.
  • Gastrointestinal stromal tumors (GIST) are rare in the vermiform appendix.
  • Here, we report 2 appendiceal gastrointestinal stromal tumors in a 78-year-old woman and a 72-year-old man with a history of endometrial adenocarcinoma and urinary bladder carcinoma, respectively.
  • Both gastrointestinal stromal tumors were incidental findings at surgery for appendicitis-like symptoms and on follow-up for bladder carcinoma, respectively.
  • Tumors were 5 and 25 mm and were located in the mid portion and the tip, respectively.
  • The larger gastrointestinal stromal tumor was pedunculated.
  • We suggest that the molecular pathogenesis of appendiceal gastrointestinal stromal tumors beyond initiating KIT mutations might be different from their gastric and intestinal counterparts.
  • The coincidence of loss of p16 and overexpression of human telomerase reverse transcriptase seems to be in contradiction to the small size, the benign nature, and the limited growth potential of appendiceal gastrointestinal stromal tumors.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Gastrointestinal Stromal Tumors / pathology

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  • (PMID = 18547614.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
  • [Number-of-references] 21
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70. Alsaad KO, Serra S, Perren A, Hsieh E, Chetty R: CK19 and CD99 immunoexpression profile in goblet cell (mucin-producing neuroendocrine tumors) and classical carcinoids of the vermiform appendix. Int J Surg Pathol; 2007 Jul;15(3):252-7
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  • [Title] CK19 and CD99 immunoexpression profile in goblet cell (mucin-producing neuroendocrine tumors) and classical carcinoids of the vermiform appendix.
  • The immunoexpression of CK19 recently has been identified as a marker of poor prognosis in pancreatic endocrine tumors and hepatocellular carcinoma.
  • The purpose of this study was to explore CK19 and CD99 immunostaining in mucin-producing neuroendocrine (goblet cell) and classical carcinoids of the appendix.
  • CK19/CD99 immunoexpression did not correlate with extent of tumor invasion and mesoappendiceal extension, mitotic activity, Ki-67 labeling index, presence of extracellular mucinous pools dissecting muscle, and angiolymphatic and perineural/neural invasion.
  • There is no difference in the immunostaining for CK19 and CD99 between GCCs and classic carcinoids, and both types of neuroendocrine tumor show the same extent of expression of both markers.
  • [MeSH-major] Antigens, CD / metabolism. Appendiceal Neoplasms / metabolism. Carcinoid Tumor / metabolism. Cell Adhesion Molecules / metabolism. Keratin-19 / metabolism
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Cell Proliferation. Gene Expression Regulation, Neoplastic. Humans. Neoplasm Invasiveness / pathology

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  • (PMID = 17652531.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Biomarkers, Tumor; 0 / CD99 protein, human; 0 / Cell Adhesion Molecules; 0 / Keratin-19
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71. Shapiro JF, Chase JL, Wolff RA, Lambert LA, Mansfield PF, Overman MJ, Ohinata A, Liu J, Wang X, Eng C: Modern systemic chemotherapy in surgically unresectable neoplasms of appendiceal origin: a single-institution experience. Cancer; 2010 Jan 15;116(2):316-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Modern systemic chemotherapy in surgically unresectable neoplasms of appendiceal origin: a single-institution experience.
  • BACKGROUND: Appendiceal neoplasms include tumors ranging from benign-appearing cells with widespread mucin deposits to aggressive poorly differentiated signet ring cell adenocarcinomas.
  • Traditionally, these tumors are treated with cytoreductive surgery followed by hyperthermic intraperitoneal chemotherapy.
  • A retrospective analysis was conducted to determine the benefit of modern systemic chemotherapy in patients with disseminated appendiceal neoplasm who were not considered optimal candidates for cytoreductive surgery.
  • Anderson Cancer Center tumor registry between January 2000 and July 2005.
  • RESULTS: Of 186 patients diagnosed with appendiceal neoplasm, 54 (29%) patients considered to be suboptimal surgical candidates received > or =2 cycles of systemic chemotherapy.
  • Thirty (55.6%) patients had a disease control rate noted as a complete response, partial response, or stable disease.
  • CONCLUSIONS: Systemic chemotherapy has a role in appendiceal neoplasm patients who are suboptimal candidates for cytoreductive surgery.
  • The intermediate PFS indicates the challenges that exist for appendiceal neoplasm patients in this setting.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Appendiceal Neoplasms / drug therapy
  • [MeSH-minor] Adult. Aged. Disease-Free Survival. Female. Humans. Hyperthermia, Induced. Injections, Intraperitoneal. Male. Middle Aged. Retrospective Studies. Survival Analysis

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  • (PMID = 19904805.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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72. Behranwala KA, Agarwal T, El-Sharkawi D, Shorvon D, Chang A: Laparoscopic resection of mucinous cystadenoma of appendix: a careful decision. Surg Laparosc Endosc Percutan Tech; 2006 Oct;16(5):347-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Laparoscopic resection of mucinous cystadenoma of appendix: a careful decision.
  • Appendiceal mucoceles are mainly due to cystadenoma or cystadenocarcinoma.
  • Definite diagnosis is difficult preoperatively and is usually peroperatively.
  • We present a case to highlight this point and especially deplore the use of laparoscopy if the tumor clearly extends beyond the appendix.
  • [MeSH-major] Appendiceal Neoplasms / surgery. Cystadenoma, Mucinous / surgery. Digestive System Surgical Procedures / methods

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  • (PMID = 17057579.001).
  • [ISSN] 1530-4515
  • [Journal-full-title] Surgical laparoscopy, endoscopy & percutaneous techniques
  • [ISO-abbreviation] Surg Laparosc Endosc Percutan Tech
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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73. Saleh H, El-Fakharany M, Frankle M: Multiple synchronous granular cell tumors involving the colon, appendix and mesentery: a case report and review of the literature. J Gastrointestin Liver Dis; 2009 Dec;18(4):475-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multiple synchronous granular cell tumors involving the colon, appendix and mesentery: a case report and review of the literature.
  • A granular cell tumor (GCT) is typically a benign neural tumor of Schwann cell origin that occurs in the 4th to 6th decade of life usually as a solitary painless nodule in the dermis or subcutis.
  • Full colonoscopy and CT-scan studies revealed multiple GCTs of the colon, appendix and the mesentery, raising the suspicion of malignant metastatic disease.
  • [MeSH-major] Appendiceal Neoplasms / diagnosis. Colonic Neoplasms / diagnosis. Granular Cell Tumor / diagnosis. Incidental Findings. Mesentery / pathology. Neoplasms, Multiple Primary

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  • (PMID = 20076822.001).
  • [ISSN] 1841-8724
  • [Journal-full-title] Journal of gastrointestinal and liver diseases : JGLD
  • [ISO-abbreviation] J Gastrointestin Liver Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Romania
  • [Number-of-references] 22
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74. Suzuki J, Kazama S, Kitayama J, Uozaki H, Miyata T, Nagawa H: Signet ring cell carcinoma of the appendix manifesting as colonic obstruction and ovarian tumors: report of a case. Surg Today; 2009;39(3):235-40
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  • [Title] Signet ring cell carcinoma of the appendix manifesting as colonic obstruction and ovarian tumors: report of a case.
  • Appendiceal cancer is rare and associated with a poor prognosis because it is usually found at an advanced stage.
  • We report a case of appendiceal adenocarcinoma manifesting as a colonic obstruction with a lower abdominal mass.
  • Laparotomy revealed bilateral ovarian tumors and a small appendiceal tumor with peritoneal metastases.
  • We performed ileocecal resection, colectomy, and oophorectomy, following which a histological diagnosis of signet ring cell carcinoma was made.
  • Immunohistochemical analysis revealed positive expression of cytokeratin 7 and 20, and mucin core protein 2 (MUC2), compatible with appendiceal cancer and Kruckenberg metastases.
  • When a patient is found to have disseminated pelvic signet ring cell carcinoma of unknown origin, the appendix should be considered as a possible primary site.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Carcinoma, Signet Ring Cell / pathology. Intestinal Obstruction / etiology. Ovarian Neoplasms / pathology
  • [MeSH-minor] Aged. Biomarkers / analysis. Female. Humans. Magnetic Resonance Imaging. Peritoneal Neoplasms / diagnosis. Peritoneal Neoplasms / secondary. Peritoneal Neoplasms / surgery. Tomography, X-Ray Computed


75. Bucher P, Gervaz P, Ris F, Oulhaci W, Inan I, Morel P: Laparoscopic versus open resection for appendix carcinoid. Surg Endosc; 2006 Jun;20(6):967-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Laparoscopic versus open resection for appendix carcinoid.
  • BACKGROUND: Since an increasing number of appendectomies are performed via laparoscopy, it is crucial to determine the impact of this approach on appendix carcinoid (AC) outcome.
  • Prognosis of AC appears more dependent on carcinoid malignant potential or associated tumors.
  • [MeSH-major] Appendectomy / methods. Appendiceal Neoplasms / surgery. Carcinoid Tumor / surgery. Laparoscopy
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Female. Follow-Up Studies. Humans. Incidence. Male. Middle Aged. Neoplasms, Multiple Primary / epidemiology. Neoplasms, Second Primary / epidemiology. Retrospective Studies

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  • (PMID = 16738993.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
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76. Lee SY, Kwon HJ, Cho JH, Oh JY, Nam KJ, Lee JH, Yoon SK, Kang MJ, Jeong JS: Actinomycosis of the appendix mimicking appendiceal tumor: a case report. World J Gastroenterol; 2010 Jan 21;16(3):395-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Actinomycosis of the appendix mimicking appendiceal tumor: a case report.
  • Actinomycosis is an uncommon chronic infectious disease.
  • In abdominopelvic actinomycosis, the ileocecal region, including the appendix, is the most commonly involved site.
  • In some reports, limited appendiceal actinomycosis has revealed a thickened appendiceal wall with peri-appendiceal inflammation as acute appendicitis or perforated appendicitis.
  • We experienced pathologically confirmed intraluminal limited appendiceal actinomycosis without peri-appendiceal infiltration.
  • [MeSH-major] Actinomycosis / diagnosis. Appendiceal Neoplasms / diagnosis. Appendicitis / diagnosis. Appendicitis / microbiology
  • [MeSH-minor] Actinomyces / isolation & purification. Appendix / microbiology. Appendix / radiography. Appendix / ultrasonography. Diagnosis, Differential. Female. Humans. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 20082489.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 11
  • [Other-IDs] NLM/ PMC2807964
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77. Mastoraki A, Papanikolaou IS, Kanakis D, Safioleas P, Sakorafas G, Safioleas M: A case of signet ring carcinoma of the appendix: dilemmas in differential diagnosis and management. J Gastrointest Cancer; 2010 Jun;41(2):141-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of signet ring carcinoma of the appendix: dilemmas in differential diagnosis and management.
  • PURPOSE: Signet ring carcinoma (SRC) of the appendix consists one of the most biologically virulent cancers.
  • We present the case of a patient with primary SRC complicated by the development of acute inflammation of the appendix.
  • Laparotomy confirmed a tumor mass which appeared to originate from the appendix.
  • The appendix was notably thickened with an ulcerated wall containing sinus tracts, chronic inflammation, and scarring.
  • CONCLUSIONS: Appendiceal SRC is a rare entity, which may sometimes be confused with other pathologies providing difficulties in differential diagnosis, having an impact on therapeutic decisions and affecting prognosis.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Carcinoma, Signet Ring Cell / pathology
  • [MeSH-minor] Abdominal Pain. Aged. Antimetabolites, Antineoplastic / therapeutic use. Antineoplastic Agents / therapeutic use. Appendicitis / complications. Appendicitis / diagnosis. Appendicitis / surgery. Chemotherapy, Adjuvant. Diagnosis, Differential. Drug Therapy, Combination. Fluorouracil / therapeutic use. Humans. Laparotomy. Leucovorin / therapeutic use. Male. Organoplatinum Compounds / therapeutic use. Vitamin B Complex / therapeutic use. Vomiting

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  • (PMID = 20058100.001).
  • [ISSN] 1941-6636
  • [Journal-full-title] Journal of gastrointestinal cancer
  • [ISO-abbreviation] J Gastrointest Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Antineoplastic Agents; 0 / Organoplatinum Compounds; 04ZR38536J / oxaliplatin; 12001-76-2 / Vitamin B Complex; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil
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78. Bisceglia M, Spagnolo D, Galliani C, Fisher C, Suster S, Kazakov DV, Cooper K, Michal M: Tumoral, quasitumoral and pseudotumoral lesions of the superficial and somatic soft tissue: new entities and new variants of old entities recorded during the last 25 years. Part XII: appendix. Pathologica; 2006 Aug;98(4):239-98

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tumoral, quasitumoral and pseudotumoral lesions of the superficial and somatic soft tissue: new entities and new variants of old entities recorded during the last 25 years. Part XII: appendix.
  • The series included fibrous and myofibroblastic tumors (e.g. solitary fibrous tumor, high grade classic and pigmented dermatofibrosarcoma protuberans, inflammatory myofibroblastic tumor and myofibrosarcomas), fibromyxoid and fibrohistiocytic neoplasms (e.g., Evans' tumor, phosphaturic mesenchymal tumor, inflammatory myxohyaline tumor), special adipocytic/vascular/and smooth muscle lesions (e.g., chondroid lipoma, Dabska's tumor, ST hemangioblastoma, lipoleiomyosarcoma), epithelioid mesenchymal malignancies of diverse lineages (e.g., epithelioid liposarcoma, proximal-type epithelioid sarcoma, neuroendocrine extraskeletal chondromyxoid sarcoma), ST Ewing's tumor and peripheral nerve sheath tumors (perineuriomas and pigmented and rosetting tumors of the schwannoma/neurofibroma group), extranodal dendritic or histiocytic proliferative processes (follicular dendritic cell sarcoma, Rosai-Dorfman disease, Castleman's disease, and plexiform xanthomatous tumor), and tumors with myoepithelial differentiation.
  • The section devoted to selected pseudotumoral entities considered representatives of the hamartoma group (neural fibrolipomatous hamartoma, ectopic hamartomatous thymoma, rudimentary meningocele), metabolic diseases (amyloid tumor, nephrogenic fibrosing dermopathy, tophaceous pseudogout, pseudoinfiltrative parathyromatosis), stromal tissue reactions to trauma (fibroosseous pseudotumors of digits) and infections (bacillary angiomatosis), and normal organs (glomus coccygeum).
  • To conclude the descriptive phase, supplementary material has now been collected and appended in an attempt to provide a quick digest of essential knowledge both for comparison and differential diagnosis.
  • At the very least we hope this final part ("Appendix") will provide the reader with a useful tabular organization of ST lesions and a reference resource.
  • [MeSH-major] Soft Tissue Neoplasms / pathology

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  • (PMID = 17175794.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 272
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79. Roy P, Chetty R: Goblet cell carcinoid tumors of the appendix: An overview. World J Gastrointest Oncol; 2010 Jun 15;2(6):251-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Goblet cell carcinoid tumors of the appendix: An overview.
  • Goblet cell carcinoid is an enigmatic and rare tumor involving the appendix almost exclusively.
  • Since its identification in 1969, understanding of this disease has evolved greatly, but issues regarding its histogenesis, nomenclature and management are still conjectural.
  • Various other names have been used for this entity such as adenocarcinoid, mucinous carcinoid, crypt cell carcinoma, and mucin-producing neuroendocrine tumor, although none have been found to be completely satisfactory or universally accepted.
  • The tumor is thought to arise from pluripotent intestinal epithelial crypt-base stem cells by dual neuroendocrine and mucinous differentiation.
  • Recently molecular studies have shown these tumors to lack the signatures of adenocarcinoma but they have some changes similar to that of ileal carcinoids (allelic loss of chromosome 11q, 16q and 18q).
  • The natural history of GCC is intermediate between carcinoids and adenocarcinomas of the appendix.
  • The most important prognostic factor is the stage of disease.
  • There is some debate about the surgical approach for these tumors, and a summary of published series and recommendations are provided.

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  • (PMID = 21160637.001).
  • [ISSN] 1948-5204
  • [Journal-full-title] World journal of gastrointestinal oncology
  • [ISO-abbreviation] World J Gastrointest Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2998842
  • [Keywords] NOTNLM ; Appendiceal neoplasm / Goblet cell carcinoid / Mucin-producing neuroendocrine tumor of appendix
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80. Elias D, Glehen O, Pocard M, Quenet F, Goéré D, Arvieux C, Rat P, Gilly F, Association Française de Chirurgie: A comparative study of complete cytoreductive surgery plus intraperitoneal chemotherapy to treat peritoneal dissemination from colon, rectum, small bowel, and nonpseudomyxoma appendix. Ann Surg; 2010 May;251(5):896-901

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A comparative study of complete cytoreductive surgery plus intraperitoneal chemotherapy to treat peritoneal dissemination from colon, rectum, small bowel, and nonpseudomyxoma appendix.
  • OBJECTIVE: To report a large number of patients with peritoneal carcinomatosis (PC) treated with complete cytoreductive (CCR-0) plus intraperitoneal chemotherapy, and to compare the results according to the origin of the primary: colon, rectum, small bowel, and appendix (excluding peritoneal pseudomyxoma).
  • Primary sites were: colon (n=341), rectum (n=27), appendix (n=41), and small bowel (n=31).
  • RESULTS: Postoperative mortality and morbidity (3.9% and 31%, respectively) did not differ according to the origin of the primary tumor.
  • The 5-year overall survival rates were not statistically different for the colon (29.7%), rectum (37.9%), nor the small bowel (33.8%), but was higher (P=0.01) for appendix adenocarcinoma (63.2%).
  • The multivariate analysis of prognostic factors singled out the extent of peritoneal seeding (P<0.0001), positive lymph nodes (P=0.001), and adjuvant systemic chemotherapy (P=0.002), whereas the origin of the tumor was borderline (P=0.06) in favor of appendix tumors.
  • Results were better for appendix adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / secondary. Appendiceal Neoplasms / pathology. Colonic Neoplasms / pathology. Intestinal Neoplasms / pathology. Peritoneal Neoplasms / secondary. Peritoneal Neoplasms / surgery. Rectal Neoplasms / pathology
  • [MeSH-minor] Combined Modality Therapy. Humans. Infusions, Parenteral. Liver Neoplasms / secondary. Multivariate Analysis. Prognosis

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  • (PMID = 20395843.001).
  • [ISSN] 1528-1140
  • [Journal-full-title] Annals of surgery
  • [ISO-abbreviation] Ann. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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81. Fornaro R, Picori E, Stabilini C, Frascio M, Sticchi C, Boccardo C, Ricci B, Giannetta E: [Carcinoid tumors of the appendix: when right colectomy?]. G Chir; 2006 May;27(5):233-9
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  • [Title] [Carcinoid tumors of the appendix: when right colectomy?].
  • [Transliterated title] I tumori carcinoidi dell'appendice. Quando l'emicolectomia destra?
  • Three cases of carcinoid tumour of the appendix (about 0,3 % of all performed appendectomies) has induced the Authors to a review of the literature with the aim to underline the most important biological and pathological findings and the current clinic and therapeutic knowledges.
  • The diagnosis before surgery is rarely made; it is formulated incidentally in most patients by the histological exam during the operation for an appendicitis or during other surgical procedures.
  • The kind of surgical intervention, that is the entity of the surgical demolition, for the treatment of the carcinoid tumours of the appendix is still controversial: appendectomy or right colectomy?
  • It is possible identify, also during the operation for an appendicitis or for other abdominal lesions, criteria that can orient toward a major surgery (size of the neoplasia, subserosal lymphatic invasion, infiltration of the serosa, diffusion in the meso-appendix, location in closeness of the base of the appendix, invasion of the the locoregional lymph nodes, presence of metastases, section ?margins, number of mitoses, cellular pleiomorfism).
  • [MeSH-major] Appendectomy. Appendiceal Neoplasms / surgery. Carcinoid Tumor / surgery. Colectomy

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  • (PMID = 16857114.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] ita
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 31
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82. Rahimi K, Gologan A, Haliotis T, Lamoureux E, Chetty R: Gastrointestinal stromal tumor with autonomic nerve differentiation and coexistent mantle cell lymphoma involving the appendix. Int J Clin Exp Pathol; 2009;2(6):608-13

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gastrointestinal stromal tumor with autonomic nerve differentiation and coexistent mantle cell lymphoma involving the appendix.
  • Gastrointestinal stromal tumor (GIST) and mantle cell lymphoma involving the appendix are rare as individual disease entities.
  • We describe a 65-year old female who presented with extensive ileocecal mantle cell lymphoma, which extended to the appendix.
  • The appendix was involved by mantle cell lymphoma and an incidental coexistent GIST was noted in the appendiceal wall.
  • This is the first description of the association of a GIST with autonomic nerve differentiation coexisting with mantle cell lymphoma in the appendix.

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  • (PMID = 19636397.001).
  • [ISSN] 1936-2625
  • [Journal-full-title] International journal of clinical and experimental pathology
  • [ISO-abbreviation] Int J Clin Exp Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2713454
  • [Keywords] NOTNLM ; Gastrointestinal stromal tumor / appendix / gastrointestinal autonomic nerve tumor / mantle cell lymphoma
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83. van Eeden S, Offerhaus GJ, Hart AA, Boerrigter L, Nederlof PM, Porter E, van Velthuysen ML: Goblet cell carcinoid of the appendix: a specific type of carcinoma. Histopathology; 2007 Dec;51(6):763-73
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Goblet cell carcinoid of the appendix: a specific type of carcinoma.
  • AIMS: Goblet cell carcinoid is a poorly understood tumour of the appendix.
  • METHODS AND RESULTS: The immunohistochemical expression pattern of 21 markers and the mutation status of KRas codon 12 were determined in 16 goblet cell carcinoids and compared with 14 classical carcinoids, 19 colonic adenocarcinomas and 10 appendiceal mucinous cystadeno (carcino)mas.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Biomarkers, Tumor / analysis. Carcinoid Tumor / pathology

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  • [CommentIn] Histopathology. 2008 May;52(6):770-1 [18439158.001]
  • (PMID = 18042066.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Grant] United States / NIMHD NIH HHS / MD / 1P20 MD001824
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / KRAS protein, human; 0 / Proto-Oncogene Proteins; EC 3.6.5.2 / ras Proteins
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84. Peitsidis P, Papadimitriou C, Rodolakis A, Peitsidou A: Actinomycosis of the appendix and pelvis: a case report. J Reprod Med; 2008 Sep;53(9):711-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Actinomycosis of the appendix and pelvis: a case report.
  • Ultrasound and computed tomography were performed, revealing an ovarian tumor formation and acute appendicitis.
  • Diagnosis of actinomycosis was established with the presence of sulphur granules microscopically.
  • Inflammatory intestinal and pelvic disease can easily mislead the diagnosis, giving the impression of a neoplastic process.
  • [MeSH-major] Actinomycosis / diagnosis. Actinomycosis / surgery. Appendicitis / microbiology. Intrauterine Devices / adverse effects. Ovarian Diseases / microbiology

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  • [CommentIn] J Reprod Med. 2009 Jun;54(6):411-2; author reply 412 [19642234.001]
  • (PMID = 18839829.001).
  • [ISSN] 0024-7758
  • [Journal-full-title] The Journal of reproductive medicine
  • [ISO-abbreviation] J Reprod Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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85. Stamatakos M, Stefanaki Ch, Tsaknaki S, Safioleas P, Iannescu R, Safioleas M: Primary adenocarcinoma of the appendix: an update. Chirurgia (Bucur); 2009 Jul-Aug;104(4):389-92

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary adenocarcinoma of the appendix: an update.
  • Adenocarcinoid arising in the vermiform appendix is a rarity.
  • The diagnosis of appendiceal adenocarcinoma has never been made preoperatively and is frequently an incidental finding at the time of operation for unrelated conditions.
  • Because of the rarity of the disease, its natural history is poorly understood.
  • [MeSH-major] Adenocarcinoma. Appendectomy. Appendiceal Neoplasms
  • [MeSH-minor] Carcinoid Tumor / diagnosis. Carcinoid Tumor / epidemiology. Carcinoid Tumor / surgery. Humans. Incidental Findings. Prognosis. Treatment Outcome

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  • (PMID = 19886044.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
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91. Yong Jiang, Huawei Liu, Hu Long, Yingying Yang, Dianying Liao, Xiuhui Zhang: Goblet cell carcinoid of the appendix: a clinicopathological and immunohistochemical study of 26 cases from southwest china. Int J Surg Pathol; 2010 Dec;18(6):488-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Goblet cell carcinoid of the appendix: a clinicopathological and immunohistochemical study of 26 cases from southwest china.
  • Goblet cell carcinoid (GCC) of the appendix is characterized by a dual differentiation of both endocrine and gland.
  • Follow-up data showed that 1 patient died from peritoneal metastasis and that the other 17 cases survived free of the tumor.
  • [MeSH-major] Appendiceal Neoplasms / metabolism. Appendiceal Neoplasms / pathology. Carcinoid Tumor / metabolism. Carcinoid Tumor / pathology
  • [MeSH-minor] Adult. Aged. Animals. Biomarkers, Tumor / analysis. China. Female. Humans. Immunohistochemistry. Male. Middle Aged. Schistosomiasis / complications

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  • (PMID = 20732910.001).
  • [ISSN] 1940-2465
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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92. Encinas JL, Avila LF, García-Cabeza MA, Luis A, Hernández F, Martínez L, Fernández A, Olivares P, Tovar JA: [Bronchial and appendiceal carcinoid tumors]. An Pediatr (Barc); 2006 May;64(5):474-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Bronchial and appendiceal carcinoid tumors].
  • [Transliterated title] Tumor carcinoide bronquial y apendicular.
  • BACKGROUND: Carcinoid tumor (CT) is an unusual neoplasm observed in several locations and associated with the production of vasoactive substances and occasionally with carcinoid syndrome (flushing, diarrhea, wheezing).
  • PATIENTS AND METHODS: A retrospective review of the medial records of all children with a diagnosis of CT treated in our service between 1966 and 2003 was performed.
  • Eight had CT of the appendix, of which 4 showed the typical clinical presentation of acute appendicitis.
  • Seven of these tumors were localized at the tip of the appendix and measured 2 cm or less.
  • In one patient, the tumor was located at the cecum and measured 3.5 cm.
  • In this patient, reoperation with ileocecal resection was performed.
  • An accurate diagnosis was made after a 1-year follow-up.
  • All the patients are currently disease-free.
  • CONCLUSIONS: Typical symptoms of acute appendicitis were not observed in half of patients with CT of the appendix.
  • In most CT of the appendix, simple appendicectomy was associated with an excellent prognosis.
  • Diagnosis of bronchial TC tends to be delayed and consequently CT should be considered in the differential diagnosis of children with respiratory symptoms unresponsive to standard medical treatment.
  • [MeSH-major] Appendiceal Neoplasms / diagnosis. Bronchial Neoplasms / diagnosis. Carcinoid Tumor / diagnosis

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  • (PMID = 16756890.001).
  • [ISSN] 1695-4033
  • [Journal-full-title] Anales de pediatría (Barcelona, Spain : 2003)
  • [ISO-abbreviation] An Pediatr (Barc)
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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93. Hayashi T, Kawahara H, Yoshimoto K, Kashiwagi H, Yanaga K, Komine K: Early cystoadenocarcinoma of vermiform appendix simulating submucosal tumor of the cecum. Int J Surg; 2008 Dec;6(6):e15-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Early cystoadenocarcinoma of vermiform appendix simulating submucosal tumor of the cecum.
  • A submucosal tumor with a maximum diameter of 5cm was detected in the cecum.
  • The tissue of the submucosal tumor was not obtained by endoscopic biopsy, and tumor diagnosis could not be confirmed by this method.
  • Because the tumor was too large to be a benign tumor, we were able to conclude it was malignant.
  • After receiving informed consent from the patient, laparoscopic right colectomy was performed for both diagnosis and treatment in June 2004.
  • As the swollen vermiform appendix pressed the cecum extraluminally, endoscopic examination indicated the possibility of submucosal tumor.
  • Postoperative pathological diagnosis was cystoadenocarcinoma, the tumor was extended within the mucosal layer, and no lymph node metastasis was detected.
  • Cancer cells were not present in the viscous liquid of the vermiform appendix intracavitary, either.
  • [MeSH-major] Appendiceal Neoplasms / diagnosis. Cystadenocarcinoma / diagnosis
  • [MeSH-minor] Cecal Neoplasms / diagnosis. Colectomy. Diagnosis, Differential. Humans. Male. Middle Aged

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  • (PMID = 19059125.001).
  • [ISSN] 1743-9159
  • [Journal-full-title] International journal of surgery (London, England)
  • [ISO-abbreviation] Int J Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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94. Tăban S, Dema A, Lazăr D, Sporea I, Lazăr E, Cornianu M: An unusual "tumor" of the cecum: the inverted appendiceal stump. Rom J Morphol Embryol; 2006;47(2):193-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An unusual "tumor" of the cecum: the inverted appendiceal stump.
  • Intussusception of the appendix in adult represents an uncommon entity.
  • A sessile polypoid tumor of cecum was discovered during colonoscopy, which was removed.
  • Histopathological examination showed that it was the case of an inverted appendiceal stump.
  • Authors present reviews of the literature concerning clinical features, associated conditions, diagnosis, classification and therapy of this extremely rare condition.
  • [MeSH-major] Appendectomy. Appendix / pathology. Cecal Neoplasms / pathology. Cecal Neoplasms / surgery

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  • (PMID = 17106530.001).
  • [ISSN] 1220-0522
  • [Journal-full-title] Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
  • [ISO-abbreviation] Rom J Morphol Embryol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Romania
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95. Suzuki O, Ono K, Sekishita Y, Fujimori M, Shiono T, Kondo S: Laparoscopic two-stage surgery for goblet cell carcinoid of the appendix: report of a case and review of the Japanese literature. Surg Laparosc Endosc Percutan Tech; 2006 Apr;16(2):106-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Laparoscopic two-stage surgery for goblet cell carcinoid of the appendix: report of a case and review of the Japanese literature.
  • Goblet cell carcinoid of the appendix is a rare clinical entity exhibiting features of both carcinoid and adenocarcinoma.
  • A 49-year-old man underwent laparoscopic appendectomy under the diagnosis of acute appendicitis.
  • A pathologic diagnosis of goblet cell carcinoid, accompanied by the aggressive proliferation, with acute appendicitis was made.
  • Subsequent laparoscopic ileocecal resection was performed, and it was verified that there were neither residual tumor nor lymph node metastases.
  • Depending upon the grade of tumor proliferation, additional resection should be considered, and our experience with this case suggests that laparoscopic 2-stage surgery is feasible for the adequate treatment of goblet cell carcinoid without complications.
  • [MeSH-major] Appendectomy / methods. Appendiceal Neoplasms / surgery. Carcinoid Tumor / surgery. Colectomy / methods. Laparoscopy / methods
  • [MeSH-minor] Anastomosis, Surgical / methods. Diagnosis, Differential. Follow-Up Studies. Humans. Male. Middle Aged

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  • (PMID = 16773013.001).
  • [ISSN] 1530-4515
  • [Journal-full-title] Surgical laparoscopy, endoscopy & percutaneous techniques
  • [ISO-abbreviation] Surg Laparosc Endosc Percutan Tech
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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96. Bolanowski M, Jarzab B, Handkiewicz-Junak D, Jeziorski A, Kos-Kudła B, Zajecki W, oraz Pozostali Uczestnicy Konferencji Okragłego Stołu: [Neuroendocrine tumors of the small intestine and the appendix - management guidelines (recommended by The Polish Network of Neuroendocrine Tumors)]. Endokrynol Pol; 2008 Jan-Feb;59(1):87-96
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Neuroendocrine tumors of the small intestine and the appendix - management guidelines (recommended by The Polish Network of Neuroendocrine Tumors)].
  • [Transliterated title] Guzy neuroendokrynne jelita cienkiego i wyrostka robaczkowego ( zasady postepowania rekomendowane przez Polska Siec Guzow Neuroendokrynnych).
  • Polish recommendations regarding management of patients suffering from neuroendocrine tumors of small intestine and appendix are presented.
  • Small intestine, especially ileum represent most common origin of these tumors.
  • Symptoms are atypical, diagnosis could be often accidental.
  • Chromogranin A is useful in the laboratory diagnostics, and urinary excretion of 5-hydroxyindoloacetic acid is helpful for the diagnostics and monitoring of the disease.
  • The treatment of choice in the neuroendocrine tumors of small intestine and appendix is radical or palliative surgery, if possible using endoscopy.
  • The crucial in biotherapy is somatostatin analogs application, possible in symptomatic treatment of hormonally functioning tumors.
  • Chemotherapy is less successful in disseminated or locally advanced intestinal neuroendocrine tumors, so radioisotope therapy should be considered in each case of unresectable tumor.
  • [MeSH-major] Intestinal Neoplasms / diagnosis. Intestinal Neoplasms / therapy. Neuroendocrine Tumors / diagnosis. Neuroendocrine Tumors / therapy. Practice Guidelines as Topic
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Appendiceal Neoplasms / diagnosis. Appendiceal Neoplasms / therapy. Clinical Competence. Combined Modality Therapy / methods. Endoscopy, Gastrointestinal / methods. Humans. Intestine, Small. Neoplasm Staging. Physical Examination. Poland. Risk Factors

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  • (PMID = 18335403.001).
  • [ISSN] 0423-104X
  • [Journal-full-title] Endokrynologia Polska
  • [ISO-abbreviation] Endokrynol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
  • [Investigator] Bar-Andziak E; Cwikła J; de Herder W; Dzielicki J; Falconi M; Foltyn W; Gaciong Z; Hubalewska-Dydejczyk A; Kowalska A; Krolicki L; Krzyzanowska-Swiniarska B; Kryszałowicz B; Kvols L; Nasierowska-Guttmejer A; O'Toole D; Kunikowska J; Lampe P; Matyja V; Mełen-Mucha G; Milewicz A; Nowak A; Nowakowska-Duława E; Omyła-Staszewska J; Pajak J; Rudzki S; Rydzewska G; Sowinski J; Starzynska T; Strzelczyk J; Sworczak K; Syrenicz A; Szawlowski A; Tomaszewska RA; Wasko-Czopnik D; Wronski M; Zemczak A; Zgliczynski W
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97. Nouri K, Demmel M, Ott J, Promberger R, Huber JC, Mayerhofer K: Villous mucinous cystadenoma of the appendix in a postmenopausal woman. JSLS; 2010 Apr-Jun;14(2):296-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Villous mucinous cystadenoma of the appendix in a postmenopausal woman.
  • Instead, a cystadenoma of the appendix was discovered during laparoscopy.
  • During diagnostic laparoscopy, the cystic lesion was found to be a distended appendix.
  • Subsequent histological analysis revealed a villous mucinous cystadenoma of the appendix with low-grade intraepithelial neoplasia.
  • CONCLUSION: Gynecologists should routinely consider this disease in the differential diagnosis of right lower dumbbell abdominal cysts.
  • Eleven percent to 20% of mucoceles are caused by mucinous cystadenocarcinomas, which carry the risk of peritoneal tumor implantation caused by rupture or laparoscopic resection.

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  • (PMID = 20932390.001).
  • [ISSN] 1086-8089
  • [Journal-full-title] JSLS : Journal of the Society of Laparoendoscopic Surgeons
  • [ISO-abbreviation] JSLS
  • [Language] ENG
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98. Hervás Benito I, Bello Arques P, Loaiza JL, Vercher JL, Velasco RP, Rivas Sánchez A, Ruiz Llorca C, Martí Vidal JF, Mateo Navarro A: [Somatostatin receptor scintigraphy in pediatric bronchial carcinoid tumor]. Rev Esp Med Nucl; 2010 Jan-Feb;29(1):25-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Somatostatin receptor scintigraphy in pediatric bronchial carcinoid tumor].
  • [Transliterated title] Gammagrafía con análogos de la somatostatina en el diagnóstico y el seguimiento del carcinoide bronquial pediátrico.
  • INTRODUCTION: Carcinoid tumor is a rare neuroendocrine neoplasm with different locations, the most frequent ones during the pediatric age being the appendix and lung.
  • Scintigraphy with (111)In-DTPA-d-Phe(1)-octreotide has led to an importance advance in the diagnosis of extension in carcinoid tumor patients.
  • CLINICAL CASES: The first patient (9 years) was studied using the SSRS after surgery due to carcinoid tumor in the right lower lobe in which tumor remains was observed (this being clearer in the tomography study).
  • The second patient (10 years) presented due to endobronchial tumor in the left lower lobe together with atelectasis of the LUL and emphysema of the LLL.
  • Radiology imaging techniques suggested the differential diagnosis between the endobronchial carcinoid tumor or plasma cells or foreign body gramuloma.
  • The SSRS showed an abnormal deposit of activity in the left hemithorax consisted with carcinoid tumor.
  • After the surgery (endobronchial resection), new controls with SSRS showed absence of disease.
  • CONCLUSION: The SSRS has demonstrated great utility in the diagnosis, follow-up and staging of pediatric patients, carriers of neuroendocrine carcinoid tumors.
  • [MeSH-major] Biomarkers, Tumor / analysis. Bronchial Neoplasms / radionuclide imaging. Carcinoid Tumor / radionuclide imaging. Lung Neoplasms / radionuclide imaging. Neoplasm Proteins / analysis. Receptors, Somatostatin / analysis
  • [MeSH-minor] Child. Diagnosis, Differential. Female. Humans. Indium Radioisotopes. Male. Octreotide / analogs & derivatives. Pneumonectomy. Postoperative Care. Postoperative Complications / etiology. Pulmonary Atelectasis / etiology. Pulmonary Emphysema / etiology. Radiopharmaceuticals. Reoperation

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  • [Copyright] Copyright 2008 Elsevier España, S.L. y SEMNIM. All rights reserved.
  • (PMID = 19819594.001).
  • [ISSN] 0212-6982
  • [Journal-full-title] Revista española de medicina nuclear
  • [ISO-abbreviation] Rev Esp Med Nucl
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Indium Radioisotopes; 0 / Neoplasm Proteins; 0 / Radiopharmaceuticals; 0 / Receptors, Somatostatin; 0 / indium-111-octreotide; RWM8CCW8GP / Octreotide
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99. Hanson NB, Lanning DK: Microbial induction of B and T cell areas in rabbit appendix. Dev Comp Immunol; 2008;32(8):980-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Microbial induction of B and T cell areas in rabbit appendix.
  • Because murine secondary lymphoid tissue development is driven by positive feedback interactions between B cells and stromal cells, we used in situ hybridization to determine whether intestinal commensals influence such interactions during rabbit appendix development.
  • Our results suggest that rabbit appendix follicles develop in two phases: an initial phase of B cell recruitment to nascent follicles, possibly through positive feedback interactions, and a subsequent phase of intrafollicular B cell proliferation stimulated by intestinal commensals.
  • In addition, we found that intestinal commensals stimulate appendix CCL21 mRNA expression and T cell area formation.

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  • (PMID = 18329710.001).
  • [ISSN] 0145-305X
  • [Journal-full-title] Developmental and comparative immunology
  • [ISO-abbreviation] Dev. Comp. Immunol.
  • [Language] ENG
  • [Grant] United States / NIAID NIH HHS / AI / AI049458-04; United States / NIAID NIH HHS / AI / R01 AI049458-05; United States / NIAID NIH HHS / AI / 1 R01 AI 49458-01A1; United States / NIAID NIH HHS / AI / R01 AI049458-04; United States / NIAID NIH HHS / AI / AI049458-05; United States / NIAID NIH HHS / AI / R01 AI049458
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chemokine CCL21; 0 / Chemokine CXCL13; 0 / Lymphotoxin beta Receptor; 0 / RNA, Messenger; 0 / Receptors, Complement 3b; 0 / Receptors, Tumor Necrosis Factor, Type I
  • [Other-IDs] NLM/ NIHMS46758; NLM/ PMC2408667
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100. Toumpanakis C, Standish RA, Baishnab E, Winslet MC, Caplin ME: Goblet cell carcinoid tumors (adenocarcinoid) of the appendix. Dis Colon Rectum; 2007 Mar;50(3):315-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Goblet cell carcinoid tumors (adenocarcinoid) of the appendix.
  • PURPOSE: Goblet cell appendiceal carcinoids represent rare tumors that exhibit histologic features of both adenocarcinomas and neuroendocrine tumors.
  • We present the long-term results of a series of 15 patients, focusing on clinical manifestations, diagnosis, and management.
  • Final diagnosis was confirmed by histology.
  • Three patients had metastases at previous diagnosis.
  • Ki67 index was greater than 20 percent in all of them, while in only one with local tumor.
  • Combination chemotherapy with either cisplatin plus etoposide or with 5-fluorouracil, cisplatin, and streptozotocin was administered to all patients with metastases resulting in temporary stabilization of disease.
  • Twelve patients are alive, while three died of their disease 9, 13, and 14 months after diagnosis.
  • CONCLUSIONS: The diagnostic value of chromogranin-A, urinary 5-hydroxy-indol-acetic acid, and (111)Indium-labeled octreotide scintigraphy seems to be limited in these tumors.
  • Ki67 index appears to predict tumor behavior.
  • Chemotherapy may have efficacy in metastatic disease, however, more data are required to determine this and the optimal regimen.
  • [MeSH-major] Appendiceal Neoplasms / diagnosis. Carcinoid Tumor / diagnosis
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Appendectomy. Biomarkers, Tumor / analysis. Cisplatin / administration & dosage. Colectomy. Combined Modality Therapy. Diagnosis, Differential. Etoposide / administration & dosage. Female. Fluorouracil / administration & dosage. Humans. Immunohistochemistry. Ki-67 Antigen / analysis. Male. Middle Aged. Neoplasm Metastasis. Retrospective Studies. Streptozocin / administration & dosage

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  • (PMID = 17195086.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 5W494URQ81 / Streptozocin; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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