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1. Nishio R, Furuya Y, Akashi T, Okumura A, Fuse H: Primary adenocarcinoma of the appendix invading the urinary bladder. Int Urol Nephrol; 2006;38(3-4):481-2
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  • [Title] Primary adenocarcinoma of the appendix invading the urinary bladder.
  • We report a case of adenocarcinoma of the appendix invading the urinary bladder in a 75-year-old man.
  • Although cystoscopic examination and computed tomography suggested a primary or secondary bladder tumor, repeated transurethral bladder biopsy could not confirm the neoplasm.
  • At operation a primary neoplasm of the appendix invading the bladder was discovered and en bloc resection of the urinary bladder with the adherent cecum followed by an ileocolonic anastomosis and ureterocutaneostomy was performed.
  • [MeSH-major] Adenocarcinoma / pathology. Appendiceal Neoplasms / pathology. Urinary Bladder Neoplasms / pathology
  • [MeSH-minor] Aged. Fatal Outcome. Humans. Male. Neoplasm Invasiveness

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  • [Cites] Br J Urol. 1996 Aug;78(2):305-6 [8813936.001]
  • [Cites] J Urol. 1995 Apr;153(4):1220-1 [7869505.001]
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  • (PMID = 17160444.001).
  • [ISSN] 0301-1623
  • [Journal-full-title] International urology and nephrology
  • [ISO-abbreviation] Int Urol Nephrol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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2. Coşkun H, Bostanci O, Dilege ME, Mihmanli M, Yilmaz B, Akgün I, Yildirim S: Carcinoid tumors of appendix: treatment and outcome. Ulus Travma Acil Cerrahi Derg; 2006 Apr;12(2):150-4
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  • [Title] Carcinoid tumors of appendix: treatment and outcome.
  • BACKGROUND: The aim of this study is to evaluate the clinical and histopathological features and the treatment of carcinoid tumors of the appendix.
  • METHODS: A retrospective review of medical records and pathology specimens of patients with carcinoid tumor of the appendix has been done.
  • RESULTS: The histopathological examination of the appendices revealed carcinoid tumor in 11 out of 6777 (0.16%) patients operated for acute appendicitis.
  • The tumor was localized in the distal 1/3 region in 10 patients and in the proximal 1/3 region in 1 patient.
  • The mean tumor diameter was 0.73+/-0.36 cm (0.3-1.5).
  • Ten patients had classical type carcinoid tumor whereas goblet cell carcinoid tumor was only seen in one patient.
  • CONCLUSION: In tumors with a diameter of 1 to 2 cm, appendectomy is the treatment of choice.
  • No recurrence was detected with tumors smaller than 2 cm with simple appendectomy.
  • [MeSH-major] Appendiceal Neoplasms / epidemiology. Appendiceal Neoplasms / surgery. Carcinoid Tumor / epidemiology. Carcinoid Tumor / surgery

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  • (PMID = 16676255.001).
  • [ISSN] 1306-696X
  • [Journal-full-title] Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES
  • [ISO-abbreviation] Ulus Travma Acil Cerrahi Derg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Turkey
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3. Beyrouti MI, Beyrouti R, Frikha F, Ben Amar M, Abid M, Ben Ameur H, Ben Salah K, Guirat A, Boujelben S: [Peritoneal gelatinous ascites]. Presse Med; 2007 Jul-Aug;36(7-8):1141-7
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  • It most often follows a mucinous tumor of the appendix.
  • Preoperative diagnosis is facilitated by modern imaging techniques.
  • Effusion in the lesser peritoneal cavity suggests this diagnosis.
  • Magnetic resonance imaging, by showing the gelatinous ascites, their septa and the scalloping of liver and spleen, can strengthen the probability of the diagnosis.
  • Recurrence is more frequent in the forms associated with malignant or bipolar tumors.
  • [MeSH-major] Peritoneal Neoplasms / diagnosis. Peritoneal Neoplasms / therapy. Pseudomyxoma Peritonei / diagnosis. Pseudomyxoma Peritonei / therapy
  • [MeSH-minor] Aged. Antineoplastic Agents / therapeutic use. Appendectomy. Biopsy, Needle. Combined Modality Therapy. Diagnosis, Differential. Female. Humans. Hyperthermia, Induced. Laparotomy. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local / etiology. Neoplasm Recurrence, Local / therapy. Paracentesis. Preoperative Care. Rare Diseases. Survival Rate. Tomography, X-Ray Computed. Treatment Outcome. Ultrasonography

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  • (PMID = 17603922.001).
  • [ISSN] 0755-4982
  • [Journal-full-title] Presse medicale (Paris, France : 1983)
  • [ISO-abbreviation] Presse Med
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 50
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4. Iwańczak B, Stawarski A, Czernik J, Bronowickip K, Iwańczak F, Pytrus T, Klempous J, Godziński J: [Diagnostic difficulties in pediatric abdominal pain with potential appendicitis]. Przegl Lek; 2007;64 Suppl 3:56-60
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  • [Transliterated title] Trudności diagnostyczne przyczyn bólów brzucha okolicy wyrostka robaczkowego u dzieci.
  • RESULTS: The most often Crohn's disease were recognized (9 children), in 2 cases with concomitant other pathologies (fecal tumor of appendix in one case and with peritoneal abscess after perforation of intestinal wall).
  • In one boy with ulcerative colitis, during exacerbation of the disease appendicitis complicated by rupture and peritonitis was observed.
  • Carcinoid of the appendix was the cause of abdominal pain in one child.
  • 3. All children with periappendipected of Crohn's disease.
  • 4. All children with equivocal presentations of appendicitis and with normal appendix during operation should undergo further diagnostic evaluation.
  • [MeSH-major] Abdominal Pain / etiology. Appendicitis / diagnosis
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Diagnosis, Differential. Female. Humans. Infant. Male

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  • (PMID = 18431916.001).
  • [ISSN] 0033-2240
  • [Journal-full-title] Przegla̧d lekarski
  • [ISO-abbreviation] Prz. Lek.
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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5. McCluggage WG, Young RH: Primary ovarian mucinous tumors with signet ring cells: report of 3 cases with discussion of so-called primary Krukenberg tumor. Am J Surg Pathol; 2008 Sep;32(9):1373-9
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  • [Title] Primary ovarian mucinous tumors with signet ring cells: report of 3 cases with discussion of so-called primary Krukenberg tumor.
  • The distinction between a primary ovarian mucinous carcinoma or even a borderline mucinous tumor and a metastatic mucinous carcinoma may be difficult.
  • One of the most important morphologic features suggesting a metastatic mucinous carcinoma in the ovary is the presence of signet ring cells; these are considered rare in primary ovarian mucinous tumors.
  • In this study, we report 3 primary ovarian mucinous tumors with a component of signet ring cells.
  • The tumors arose in patients aged 27, 55, and 60, were unilateral, confined to the ovary and stage IA.
  • In one case, the neoplasm had the architecture of a mucinous adenofibroma but had frankly malignant cells lining glands and forming solid aggregates of cells.
  • A second tumor also had the background of an adenofibroma.
  • Investigations to exclude a gastrointestinal neoplasm in 2 cases were negative.
  • Features favoring a primary rather than a metastatic neoplasm are unilateral tumor, low stage, background of adenofibroma or cystadenoma, associated endometriosis in 1 case and an absence of features which are characteristic of secondary mucinous carcinomas in the ovary, such as surface tumor deposits, a nodular growth pattern, and lymphovascular permeation.
  • Immunohistochemistry is of limited value because of overlapping immunophenotype between a primary ovarian mucinous tumor and a metastasis from the stomach, pancreas, biliary tree, appendix, or colorectum, the most likely primary sites for a secondary exhibiting similar features.
  • Our study illustrates that signet ring cells occur rarely in a primary ovarian mucinous tumor; even when conspicuous the features differ from those of the usual Krukenberg tumor.
  • At least some cases of so-called primary Krukenberg tumor may be similar to our cases.
  • However, the designation primary Krukenberg tumor should not be used as, apart from the signet ring cells, a resemblance to a "true" Krukenberg tumor of the secondary type is limited.
  • The tumors should be classified according to the underlying background neoplasm with a notation concerning the signet ring cell component.
  • [MeSH-major] Cystadenocarcinoma, Mucinous / pathology. Krukenberg Tumor / pathology. Ovarian Neoplasms / pathology

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  • (PMID = 18670351.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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6. Palomino-Portilla EA, Valbuena JR, Quinones-Avila Mdel P, Medeiros LJ: Myeloid sarcoma of appendix mimicking acute appendicitis. Arch Pathol Lab Med; 2005 Aug;129(8):1027-31
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  • [Title] Myeloid sarcoma of appendix mimicking acute appendicitis.
  • CONTEXT: Myeloid sarcoma is a neoplasm of immature myeloid cells involving an extramedullary anatomic site that is usually, although not always, associated with acute myeloid leukemia.
  • Any extramedullary site can be involved by myeloid sarcoma, but involvement of the cecal appendix is uncommon, and symptoms mimicking acute appendicitis as a result of appendiceal involvement are rare.
  • OBJECTIVE: To describe the clinicopathologic features of 2 patients with myeloid sarcoma involving the appendix who presented with right lower quadrant pain suggestive of acute appendicitis and prompting appendectomy.
  • Histologic examination of the appendix revealed poorly differentiated myeloid sarcoma in both cases.
  • Each neoplasm was positive for chloroacetate esterase, myeloperoxidase, lysozyme, and CD43 and was negative for CD3 and CD20.
  • CONCLUSIONS: Myeloid sarcoma involving the appendix can rarely cause pain or other symptoms mimicking acute appendicitis.
  • A high index of suspicion combined with the use of cytochemical and immunohistochemical studies are helpful in establishing the diagnosis.
  • [MeSH-major] Appendicitis / diagnosis. Appendix / pathology. Leukemia, Myeloid / diagnosis. Sarcoma, Myeloid / diagnosis
  • [MeSH-minor] Abdomen / ultrasonography. Adult. Biomarkers, Tumor / metabolism. Chemotherapy, Adjuvant. Child. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Palliative Care. Radiotherapy. Retrospective Studies. Treatment Outcome

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  • (PMID = 16048393.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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7. Yildiz BD, Abbasoglu O: Two unusual presentations of appendiceal masses. Int J Surg; 2008 Dec;6(6):e9-11
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  • [Title] Two unusual presentations of appendiceal masses.
  • Appendix is one of the most common organs harboring intra-abdominal pathologies both in acute and chronic settings.
  • Appendiceal diseases in elderly population is hard to differentiate owing to the age related changes and wide spectrum of differential diagnosis.
  • Even uncomplicated diseases of the appendix can have features mimicking a neoplasm.
  • Here we present two cases of appendiceal masses.
  • First case presented with symptoms and findings of an invasive neoplasm and the second case had findings of a pelvic mass.

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  • (PMID = 19059141.001).
  • [ISSN] 1743-9159
  • [Journal-full-title] International journal of surgery (London, England)
  • [ISO-abbreviation] Int J Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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8. Badmos KB, Sabageh D, Ojo OS, Balogun OS: Eosinophilic colitis presenting as a right iliac fossa mass--a case report. West Afr J Med; 2008 Jul;27(3):175-7
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  • Involvement of caecum, appendix, ascending colon and the omentum by the inflammatory process could mimic a right iliac fossa neoplasm.
  • OBJECTIVE: To highlight the diagnostic challenges posed by eosinophilic colitis and the import of histopathological diagnosis in the treatment of such a patient.
  • At surgery, the mass was found to be a complex of caecum, ascending colon, appendix and the omentum.
  • Histological diagnosis of the resected mass was eosinophilic colitis with peritonitis.
  • CONCLUSION: Eosinophilic colitis is rare and could mimic a right iliac neoplasm if it is right-sided.
  • Histopathological diagnosis of all specimens removed at surgery particularly in a peripheral district hospital is very important in patient's management.
  • [MeSH-major] Colitis / diagnosis. Eosinophilia / diagnosis. Ileal Neoplasms / diagnosis
  • [MeSH-minor] Colon / pathology. Diagnosis, Differential. Female. Humans. Middle Aged

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  • (PMID = 19256325.001).
  • [ISSN] 0189-160X
  • [Journal-full-title] West African journal of medicine
  • [ISO-abbreviation] West Afr J Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Nigeria
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9. Ratanarapee S, Nualyong C: Acute appendicitis as primary symptom of prostatic adenocarcinoma: report of a case. J Med Assoc Thai; 2010 Nov;93(11):1327-31
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  • The most common disease ofappendix is acute appendicitis.
  • The authors reported a 62-year-old Thai man who underwent appendectomy due to classical symptoms and signs of acute appendicitis and was subsequently referred to Siriraj Hospital for proper management after a pathological report of metastatic adenocarcinoma to the appendix.
  • The patient was doing well for two years before upper gastrointestinal hemorrhage and obstructive jaundice caused by another aggressive tumor developed.
  • He died of the second tumor associated with subsequent renal failure in spite of good response to orchidectomy.
  • [MeSH-major] Adenocarcinoma / secondary. Appendiceal Neoplasms / secondary. Appendicitis / diagnosis. Prostatic Neoplasms / pathology
  • [MeSH-minor] Appendectomy. Asian Continental Ancestry Group. Biopsy. Diagnosis, Differential. Humans. Male. Middle Aged. Neoplasm Metastasis. Orchiectomy. Prostate-Specific Antigen / blood. Treatment Outcome

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  • (PMID = 21114214.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Thailand
  • [Chemical-registry-number] EC 3.4.21.77 / Prostate-Specific Antigen
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10. Chen CF, Huang CJ, Kang WY, Hsieh JS: Experience with adjuvant chemotherapy for pseudomyxoma peritonei secondary to mucinous adenocarcinoma of the appendix with oxaliplatin/fluorouracil/leucovorin (FOLFOX4). World J Surg Oncol; 2008;6:118
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  • [Title] Experience with adjuvant chemotherapy for pseudomyxoma peritonei secondary to mucinous adenocarcinoma of the appendix with oxaliplatin/fluorouracil/leucovorin (FOLFOX4).
  • BACKGROUND: Pseudomyxoma peritonei (PMP) is a rare condition characterized by mucinous tumors, disseminated intra-peritoneal implants, and mucinous ascites.
  • So far its diagnosis remains challenging to most clinicians.
  • There was a lot of mucinous ascites, one appendiceal tumor and multiple peritoneal implants disseminated from the subphrenic space to the recto-vesicle pouch.
  • Pseudomyxoma Peritonei caused by mucinous adenocarcinoma of appendiceal origin, was confirmed by histopathology.
  • We performed an excision of the appendiceal tumor combined with copious irrigation and debridement.
  • [MeSH-major] Adenocarcinoma, Mucinous / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Appendiceal Neoplasms / drug therapy. Peritoneal Neoplasms / drug therapy. Pseudomyxoma Peritonei / drug therapy

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  • (PMID = 19014441.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; 04ZR38536J / oxaliplatin; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil
  • [Other-IDs] NLM/ PMC2615010
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11. Pitiakoudis M, Kirmanidis M, Tsaroucha A, Christianakis E, Filippou D, Sivridis E, Simopoulos C: Carcinoid tumor of the appendix during pregnancy. A rare case and a review of the literature. J BUON; 2008 Apr-Jun;13(2):271-5
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  • [Title] Carcinoid tumor of the appendix during pregnancy. A rare case and a review of the literature.
  • We present a rare case of a carcinoid tumor of the appendix that was diagnosed during pregnancy in a 24-year-old female.
  • Only few similar cases were found in the literature reporting appendiceal carcinoid tumor during pregnancy.
  • [MeSH-major] Appendiceal Neoplasms / surgery. Carcinoid Tumor / surgery. Pregnancy Complications, Neoplastic / pathology. Pregnancy Complications, Neoplastic / surgery


12. Benedix F, Reimer A, Gastinger I, Mroczkowski P, Lippert H, Kube R, Study Group Colon/Rectum Carcinoma Primary Tumor: Primary appendiceal carcinoma--epidemiology, surgery and survival: results of a German multi-center study. Eur J Surg Oncol; 2010 Aug;36(8):763-71
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  • [Title] Primary appendiceal carcinoma--epidemiology, surgery and survival: results of a German multi-center study.
  • BACKGROUND: While carcinoma of the colon is a common malignancy, primary carcinoma of the appendix is rare.
  • Many retrospective reviews outlined experience from different centers on appendiceal neoplasms.
  • The aim of this study was to analyze the type of surgery and survival of patients with appendiceal malignancies using data from a German multi-center observational study (31 341 patients).
  • METHODS: During a five-year period, 196 consecutive patients with malignant appendiceal tumors were distributed into four groups: appendiceal carcinoids, adenocarcinoma, mucinous adenocarcinoma and adenosquamous carcinoma.
  • Mean age at presentation was youngest for carcinoid tumors.
  • Carcinoid tumors had lowest tumor size and localized disease was present in 72.9%.
  • Overall 5-year survival was 83.1% for carcinoid vs. 49.2% for non-carcinoid tumors.
  • Histological subtype and tumor stage significantly affected survival.
  • CONCLUSIONS: Long-term outcome of carcinoid tumors is superior to non-carcinoid neoplasms.
  • Among all appendiceal neoplasms, adenosquamous carcinoma is the rarest histological subtype which is most commonly associated with advanced tumor stage and worst prognosis.
  • However, the high rate of right hemicolectomy in patients with small carcinoid tumors needs to be critically discussed.
  • [MeSH-major] Appendiceal Neoplasms / epidemiology. Appendiceal Neoplasms / surgery. Colectomy
  • [MeSH-minor] Adenocarcinoma / epidemiology. Adenocarcinoma / surgery. Adenocarcinoma, Mucinous / epidemiology. Adenocarcinoma, Mucinous / surgery. Adult. Aged. Appendicitis / diagnosis. Carcinoid Tumor / epidemiology. Carcinoid Tumor / surgery. Carcinoma, Adenosquamous / epidemiology. Carcinoma, Adenosquamous / surgery. Diagnosis, Differential. Female. Germany. Humans. Male. Middle Aged. Neoplasm Staging. Unnecessary Procedures / statistics & numerical data

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  • [Copyright] Copyright (c) 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20561765.001).
  • [ISSN] 1532-2157
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] England
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13. Kinkor Z, Michal M: [Syndrome of pseudomyxoma peritonei--description of three cases and survey of the problem]. Ceska Gynekol; 2005 Jan;70(1):67-72
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  • First and more frequent, so-called disseminated peritoneal adenomucinosis, where primary low grade (benign) mucinous appendiceal tumor is almost constant finding, often recurs but displays favorable prognosis.
  • A normal macroscopic finding on appendix or "uneventful" appendectomy in anamnesis is not unusual.

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  • (PMID = 15779299.001).
  • [ISSN] 1210-7832
  • [Journal-full-title] Ceska gynekologie
  • [ISO-abbreviation] Ceska Gynekol
  • [Language] CZE
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Czech Republic
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14. Deschamps L, Couvelard A: Endocrine tumors of the appendix: a pathologic review. Arch Pathol Lab Med; 2010 Jun;134(6):871-5
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  • [Title] Endocrine tumors of the appendix: a pathologic review.
  • CONTEXT: Although rare, appendiceal endocrine tumors are the most common neoplasms of the appendix.
  • OBJECTIVE: To provide recent data that focus on the pathology of endocrine tumors of the appendix including classifications and guidelines for patient management.
  • CONCLUSIONS: Appendiceal endocrine tumors are separated into 2 main groups: classic endocrine tumors and goblet cell carcinoids.
  • Evaluation of their prognoses and risks of malignancy, according to these classifications, depends on several parameters including tumor size, proliferation rate, and infiltration of appendiceal wall and mesoappendix.
  • Most patients with classic endocrine tumors of the appendix have a favorable prognosis.
  • Indications for postappendectomy, complementary surgery, which are still controversial, especially for tumors between 1 and 2 cm, are presented and discussed.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Carcinoma, Neuroendocrine / pathology
  • [MeSH-minor] Appendectomy. Carcinoid Tumor / classification. Carcinoid Tumor / diagnosis. Carcinoid Tumor / pathology. Colectomy. Humans. Prognosis. World Health Organization

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  • (PMID = 20524865.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 41
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15. Wu CL, Yu CC: Amyand's hernia with adenocarcinoid tumor. Hernia; 2010 Aug;14(4):423-5
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  • [Title] Amyand's hernia with adenocarcinoid tumor.
  • Also, neoplasms of the appendix is quite uncommon.
  • Adenocarcinoid tumor of the appendix was noted after the operation.
  • [MeSH-major] Appendiceal Neoplasms / complications. Appendicitis / complications. Hernia, Inguinal / complications

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  • (PMID = 19756915.001).
  • [ISSN] 1248-9204
  • [Journal-full-title] Hernia : the journal of hernias and abdominal wall surgery
  • [ISO-abbreviation] Hernia
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] Adenocarcinoid tumor
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16. Smeenk RM, van Velthuysen ML, Verwaal VJ, Zoetmulder FA: Appendiceal neoplasms and pseudomyxoma peritonei: a population based study. Eur J Surg Oncol; 2008 Feb;34(2):196-201
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  • [Title] Appendiceal neoplasms and pseudomyxoma peritonei: a population based study.
  • BACKGROUND: Pseudomyxoma peritonei (PMP) is a rare disease with an estimated incidence of 1 per million per year, and is thought to originate usually from an appendiceal mucinous epithelial neoplasm.
  • However it is not known exactly how often these neoplasms lead to PMP.
  • METHODS: The nationwide pathology database of the Netherlands (PALGA) was searched for the incidence of all appendectomies, the incidence of primary epithelial appendiceal lesions and the incidence and pathology history of patients with PMP.
  • An appendiceal lesion was found in 1482 appendiceal specimens (0.9%).
  • Coincidentally, an additional epithelial colonic neoplasm was found in 13% of patients with an appendiceal epithelial lesion.
  • A mucinous epithelial neoplasm was identified in 0.3% (73% benign, 27% malignant) of appendiceal specimens and 20% of these patients developed PMP.
  • For mucocele and non-mucinous neoplasm the association with PMP was only 2% and 3%, respectively.
  • The primary site was identified in 68% and dominated by the appendix (82%).
  • CONCLUSIONS: Primary epithelial lesions of the appendix are rare.
  • One third of these lesions are mucinous epithelial neoplasms and especially these tumours may progress into PMP.
  • Furthermore there is a considerable risk of an additional colonic epithelial neoplasm in patients with an epithelial neoplasm at appendectomy.
  • [MeSH-major] Adenocarcinoma, Mucinous / epidemiology. Appendiceal Neoplasms / epidemiology. Neoplasms, Multiple Primary / epidemiology. Peritoneal Neoplasms / epidemiology. Pseudomyxoma Peritonei / epidemiology

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  • (PMID = 17524597.001).
  • [ISSN] 1532-2157
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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17. Dimov ND, Medeiros LJ, Kantarjian HM, Cortes JE, Chang KS, Bueso-Ramos CE, Ravandi F: Rapid and reliable confirmation of acute promyelocytic leukemia by immunofluorescence staining with an antipromyelocytic leukemia antibody: the M. D. Anderson Cancer Center experience of 349 patients. Cancer; 2010 Jan 15;116(2):369-76
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  • BACKGROUND: The authors evaluated the utility of immunofluorescence staining with an antipromyelocytic leukemia (anti-PML) antibody for patients with a suspected diagnosis of new or relapsed acute promyelocytic leukemia (APL) and correlated the findings with the results of other established diagnostic modalities.
  • METHODS: Bone marrow (BM) and/or peripheral blood (PB) smears from 349 patients in whom the diagnosis of APL was considered were assessed with the anti-PML antibody using immunofluorescence.
  • [MeSH-major] Antibodies, Neoplasm. Fluorescent Antibody Technique / methods. Leukemia, Promyelocytic, Acute / diagnosis. Nuclear Proteins. Transcription Factors. Tumor Suppressor Proteins
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Diagnosis, Differential. Female. Humans. In Situ Hybridization, Fluorescence. Infant. Karyotyping. Male. Middle Aged. Reverse Transcriptase Polymerase Chain Reaction. Sensitivity and Specificity

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  • (PMID = 19950129.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA016672
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Neoplasm; 0 / Nuclear Proteins; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins; 143220-95-5 / PML protein, human
  • [Other-IDs] NLM/ NIHMS629441; NLM/ PMC4180261
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18. Scoazec JY: [Appendicular pathology. Mucous neuroma]. Ann Pathol; 2010 Apr;30(2):130-4
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  • [Transliterated title] Pathologie de l'appendice. Cas no 8. Névrome muqueux.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Appendicitis / etiology. Appendix / pathology. Neuroma / pathology
  • [MeSH-minor] Appendectomy. Biomarkers, Tumor / analysis. Humans. Hyperplasia. Intestinal Mucosa / pathology. Male. Middle Aged. Neoplasm Proteins / analysis. Nerve Fibers / pathology. S100 Proteins / analysis. Ubiquitin Thiolesterase / analysis

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  • (PMID = 20451072.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; 0 / S100 Proteins; EC 3.1.2.15 / UCHL1 protein, human; EC 3.1.2.15 / Ubiquitin Thiolesterase
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19. Thirunavukarasu P, Sathaiah M, Singla S, Sukumar S, Karunamurthy A, Pragatheeshwar KD, Lee KK, Zeh H 3rd, Kane KM, Bartlett DL: Medullary carcinoma of the large intestine: a population based analysis. Int J Oncol; 2010 Oct;37(4):901-7
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  • To date, there has been no epidemiological study of this rare tumor type, which has now been incorporated as a separate entity in the World Health Organization (WHO) classification of colorectal cancers.
  • We observed that MCs were rare tumors, constituting approximately 5-8 cases for every 10,000 colon cancers diagnosed, with a mean annual incidence of 3.47 (+/-0.75) per 10 million population.
  • Mean age at diagnosis was 69.3 (+/-12.5) years, with incidence increasing with age.
  • There were no cases reliably identified in the rectum or appendix.
  • MCs commonly presented with Stage II disease, with 10% presenting with metastases.
  • Only one patient presented with N2b disease (>7 positive nodes).
  • [MeSH-major] Adenocarcinoma / epidemiology. Carcinoma, Medullary / epidemiology. Colorectal Neoplasms / epidemiology
  • [MeSH-minor] Age Distribution. Age Factors. Aged. Aged, 80 and over. Carcinoembryonic Antigen / blood. Cell Differentiation. Ethnic Groups. Female. Humans. Incidence. Kaplan-Meier Estimate. Male. Middle Aged. Neoplasm Staging. Neoplasms, Multiple Primary / epidemiology. Prognosis. SEER Program. Sex Distribution. Sex Factors. Survival Rate. Time Factors. United States

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  • (PMID = 20811712.001).
  • [ISSN] 1791-2423
  • [Journal-full-title] International journal of oncology
  • [ISO-abbreviation] Int. J. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / T32 CA113263
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen
  • [Other-IDs] NLM/ NIHMS609288; NLM/ PMC4127912
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20. Hervieu V: [Appendicular pathology. Low-grade mucinous cystadenoma]. Ann Pathol; 2010 Apr;30(2):101-7
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  • [Transliterated title] Pathologie de l'appendice. Cas no 2. Cystadénome mucineux de bas grade.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Appendix / pathology. Cecal Diseases / etiology. Cystadenoma, Mucinous / pathology. Mucocele / etiology
  • [MeSH-minor] Adenocarcinoma, Mucinous / diagnosis. Adenoma / diagnosis. Aged. Appendicitis / diagnosis. Biomarkers, Tumor / analysis. Diagnosis, Differential. Epithelial Cells / chemistry. Epithelial Cells / secretion. Epithelial Cells / ultrastructure. Female. Humans. Keratin-20 / analysis. Ki-67 Antigen / analysis. Mucin-2 / analysis. Neoplasm Proteins / analysis. Prognosis. Pseudomyxoma Peritonei / diagnosis. Pseudomyxoma Peritonei / etiology

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  • (PMID = 20451066.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Keratin-20; 0 / Ki-67 Antigen; 0 / MUC2 protein, human; 0 / Mucin-2; 0 / Neoplasm Proteins
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21. Haase E, Yoo D, Sugarbaker PH: Management of appendiceal pseudomyxoma peritonei diagnosed during pregnancy. World J Surg Oncol; 2009;7:48
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  • [Title] Management of appendiceal pseudomyxoma peritonei diagnosed during pregnancy.
  • Epithelial tumors of the appendix on the other hand are rare and account for only approximately 1% of all colorectal neoplasms; the occurrence of this neoplasm during pregnancy is extremely rare.
  • CASE PRESENTATION: The medical history of a 30 year old woman diagnosed at 17 weeks gestation with an appendiceal mucinous tumor with large volume pseudomyxoma peritonei was presented.
  • She remains disease-free 5 years after her initial diagnosis.
  • CONCLUSION: The management of an appendiceal tumor with pseudomyxoma peritonei diagnosed during pregnancy requires full knowledge of the natural history of this disease to achieve a balance of concern for maternal survival and fetal health.
  • [MeSH-major] Appendiceal Neoplasms / surgery. Peritoneal Neoplasms / surgery. Pregnancy Complications, Neoplastic / surgery. Pseudomyxoma Peritonei / surgery

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  • (PMID = 19454019.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 18
  • [Other-IDs] NLM/ PMC2688488
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22. Abdalla MF, El-Hennawy HM: Unusual presentation for primary appendiceal lymphoma: A case report. Indian J Surg; 2010 Jul;72(Suppl 1):289-92
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  • [Title] Unusual presentation for primary appendiceal lymphoma: A case report.
  • Primary appendiceal neoplasms are uncommon, being found in approximately 0.5%-1.0% of appendectomy specimens at pathologic evaluation.
  • Primary appendiceal Burkitt's lymphomas are rare occurring in 0.015% of all gastrointestinal lymphomas.
  • Almost all reported cases of appendiceal lymphoma have proved to be non-Hodgkin lymphoma.
  • The majority of appendiceal lymphomas are of B-cell.
  • This report describes a rare case of primary appendiceal lymphoma in a patient presented with hematuria and dull aching right lower abdominal and back pain.

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  • (PMID = 23133274.001).
  • [ISSN] 0972-2068
  • [Journal-full-title] The Indian journal of surgery
  • [ISO-abbreviation] Indian J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3451848
  • [Keywords] NOTNLM ; Appendix / Burkitt’s / Lymphoma
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23. Hernández-Ramírez DA, Portela-Rubio G, Suárez-Moreno RM, Salazar-Lozano CR, Madrazo-Navarro M: [Mucocele of the appendix: an unusual finding in a patient with ulcerative colitis]. Cir Cir; 2010 Jul-Aug;78(4):357-60
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  • [Title] [Mucocele of the appendix: an unusual finding in a patient with ulcerative colitis].
  • BACKGROUND: Patients with ulcerative colitis (UC) or Crohn's disease (CD) have an increased risk for the development of colorectal dysplasia and carcinoma.
  • Although appendiceal inflammation occurs histologically in 40-86% of colectomy specimens from patients with inflammatory bowel disease (IBD), appendiceal neoplasms have been reported only infrequently, and the notion of a direct association between IBD and appendiceal neoplasia is speculative.
  • Colonoscopy and biopsy established the diagnosis of UC (proctosigmoiditis).
  • Disease activity was moderate at the beginning and the patient initially received medical treatment with mesalazine and prednisone.
  • Final histological report revealed cystadenoma of the appendix.
  • CONCLUSIONS: We present the eighth patient, to our knowledge, with a primary cystadenoma of the appendix and UC.
  • [MeSH-major] Appendiceal Neoplasms / complications. Colitis, Ulcerative / complications. Cystadenoma / complications. Mucocele / etiology

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  • (PMID = 21167104.001).
  • [ISSN] 0009-7411
  • [Journal-full-title] Cirugía y cirujanos
  • [ISO-abbreviation] Cir Cir
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Mexico
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24. Miyazaki T, Ishiguro T, Ishibashi K, Itoyama S, Ishida H: Mucosa-associated lymphoid tissue lymphoma of the appendix vermiformis. Int Surg; 2010 Jan-Mar;95(1):27-32
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  • [Title] Mucosa-associated lymphoid tissue lymphoma of the appendix vermiformis.
  • Computed tomography demonstrated right hydronephrosis and an irregular mass of 4 x 3 cm adjacent to the ileocecal region and iliopsoas muscle.
  • Laparotomy showed an appendiceal tumor invading the cecum, mesocolon, right ureter, and duodenum.
  • This is the sixth documented case of primary MALT lymphoma of the appendix.
  • The spectrum of sites in which gastrointestinal MALT lymphomas occur should be expanded to include the appendix.
  • [MeSH-major] Appendiceal Neoplasms / surgery. Lymphoma, B-Cell, Marginal Zone / surgery
  • [MeSH-minor] Antibodies, Monoclonal / blood. Antibodies, Monoclonal, Murine-Derived. Antigens, CD79 / blood. Female. Humans. Immunohistochemistry. Middle Aged. Neoplasm Invasiveness. Rituximab. Tomography, X-Ray Computed

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  • (PMID = 20480837.001).
  • [ISSN] 0020-8868
  • [Journal-full-title] International surgery
  • [ISO-abbreviation] Int Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antigens, CD79; 4F4X42SYQ6 / Rituximab
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25. Elias D, Honoré C, Ciuchendéa R, Billard V, Raynard B, Lo Dico R, Dromain C, Duvillard P, Goéré D: Peritoneal pseudomyxoma: results of a systematic policy of complete cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. Br J Surg; 2008 Sep;95(9):1164-71
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  • BACKGROUND: Pseudomyxoma peritonei (PMP) is characterized by progressive intraperitoneal accumulation of mucous and mucinous implants, usually derived from a ruptured, possibly malignant mucinous neoplasm of the appendix.
  • Overall and disease-free 5-year survival rates were 80.0 and 68.5 per cent respectively.
  • The Cox model identified only two significant factors impacting on disease-free survival: CA19.9 level and pathological grade.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Peritoneal Neoplasms / drug therapy. Peritoneal Neoplasms / surgery. Pseudomyxoma Peritonei / drug therapy. Pseudomyxoma Peritonei / surgery
  • [MeSH-minor] Chemotherapy, Adjuvant / methods. Combined Modality Therapy / methods. Disease-Free Survival. Female. Fluorouracil / administration & dosage. Humans. Hyperthermia, Induced. Injections, Intraperitoneal. Male. Organoplatinum Compounds / administration & dosage. Preoperative Care / methods. Prognosis. Prospective Studies. Treatment Outcome

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  • (PMID = 18690633.001).
  • [ISSN] 1365-2168
  • [Journal-full-title] The British journal of surgery
  • [ISO-abbreviation] Br J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Organoplatinum Compounds; 04ZR38536J / oxaliplatin; U3P01618RT / Fluorouracil
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26. Oh S, Stish BJ, Sachdev D, Chen H, Dudek AZ, Vallera DA: A novel reduced immunogenicity bispecific targeted toxin simultaneously recognizing human epidermal growth factor and interleukin-4 receptors in a mouse model of metastatic breast carcinoma. Clin Cancer Res; 2009 Oct 1;15(19):6137-47
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  • PURPOSE: To develop a targeted biological drug that when systemically injected can penetrate to metastatic breast cancer tumors, one needs a drug of high potency and reduced immunogenicity.

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  • [Cites] Mol Med. 2000 Mar;6(3):165-78 [10965493.001]
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  • (PMID = 19789305.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA036725-24; United States / NCI NIH HHS / CA / R01 CA108637; United States / NCI NIH HHS / CA / R01 CA082154; United States / NCI NIH HHS / CA / R01 CA108637-04; United States / NCI NIH HHS / CA / R01 CA036725; United States / NCI NIH HHS / CA / R01-CA36725; United States / NCI NIH HHS / CA / R01-CA082154; United States / NCI NIH HHS / CA / CA036725-24; United States / NCI NIH HHS / CA / R01 CA108637-03; United States / NCI NIH HHS / CA / CA108637-04; United States / NCI NIH HHS / CA / CA108637-03; United States / NCI NIH HHS / CA / R01 CA036725-23; United States / NCI NIH HHS / CA / CA036725-23
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Immunotoxins; 0 / Receptors, Interleukin-4; 0 / Recombinant Fusion Proteins; 62229-50-9 / Epidermal Growth Factor
  • [Other-IDs] NLM/ NIHMS127356; NLM/ PMC2756320
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27. Zedníková I, Kuntscher V, Schmiedhuber P, Daum O: [Mucinous adenocarcinoma of the appendix--case report]. Rozhl Chir; 2010 Nov;89(11):682-4
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  • [Title] [Mucinous adenocarcinoma of the appendix--case report].
  • [Transliterated title] Mucinózni adenokarcinom apendixu--kazuistika.
  • The authors are describing a case of a patient with the diagnosis of the appendicular cancer.
  • The 66-year-old patient underwent appendectomy because of signs of acute appendicitis, and than in the next step right-sided hemicolectomy because of histological finding of the mucinous adenocarcinoma of the appendix.
  • Mucinous adenocarcinoma is the most common type of appendicular cancer, none the less this diagnosis is very rare.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Appendiceal Neoplasms / diagnosis
  • [MeSH-minor] Aged. Colectomy. Humans. Male. Neoplasm Invasiveness

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  • (PMID = 21409802.001).
  • [ISSN] 0035-9351
  • [Journal-full-title] Rozhledy v chirurgii : měsíčník Československé chirurgické společnosti
  • [ISO-abbreviation] Rozhl Chir
  • [Language] cze
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Czech Republic
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28. Varona JF, Guerra JM, Salamanca J, Colina F, Lopez G, Morales M: Pseudomyxoma peritonei: a clinicopathologic analysis and follow-up of 21 patients. Hepatogastroenterology; 2005 May-Jun;52(63):812-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND/AIMS: Pseudomyxoma peritonei is an uncommon disease characterized by the presence of mucinous peritoneal implants associated with an abdominal neoplasm.
  • The most frequent primary site of origin of the pseudomyxoma was the appendix (10 cases).
  • The histologic diagnosis was malignant (associated with carcinoma) in 17 cases and indeterminate behavior in 4.
  • The appendix is the most frequent primary site of origin of pseudomyxoma peritonei, followed by bowel; the latter being more important than previously described.
  • [MeSH-major] Gastrointestinal Neoplasms / pathology. Ovarian Neoplasms / pathology. Peritoneal Neoplasms / pathology. Pseudomyxoma Peritonei / pathology

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  • (PMID = 15966210.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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29. Vidarsdottir H, Moller PH, Benediktsdottir KR, Geirsson G: Adenocarcinoma of the appendix with a fistula to the urinary bladder. Scand J Urol Nephrol; 2010 Nov;44(5):354-6
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  • [Title] Adenocarcinoma of the appendix with a fistula to the urinary bladder.
  • Adenocarcinoma of the vermiform appendix is a rare disease that constitutes less than 0.5% of all gastrointestinal malignancies.
  • She was diagnosed with adenocarcinoma of the appendix with a fistula to the urinary bladder.
  • [MeSH-major] Adenocarcinoma / complications. Appendiceal Neoplasms / complications. Urinary Fistula / etiology
  • [MeSH-minor] Female. Humans. Magnetic Resonance Imaging. Middle Aged. Neoplasm Invasiveness

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  • (PMID = 20509819.001).
  • [ISSN] 1651-2065
  • [Journal-full-title] Scandinavian journal of urology and nephrology
  • [ISO-abbreviation] Scand. J. Urol. Nephrol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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30. Maier M, Kettelhack Ch, Adams H, Bongartz G, Sonnet S: [Presentation of right lower quadrant pain with atypical findings]. Praxis (Bern 1994); 2006 May 31;95(22):907-11
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  • Laparoscopy showed a ruptured appendiceal mucocele with peritoneal adherent mucus.
  • The patient was treated with ileocecal resection.
  • Histopathological examination revealed an infiltrating mucinous cystadenocarcinoma of the appendix.
  • Despite typical clinical signs of appendicitis a sonographically atypical cystic mass in the right lower abdomen should raise suspicion of a mucocele, eventually on the base of a neoplasm.
  • [MeSH-major] Abdominal Pain / etiology. Appendiceal Neoplasms / ultrasonography. Appendicitis / ultrasonography. Cecal Diseases / ultrasonography. Cystadenocarcinoma / ultrasonography. Mucocele / ultrasonography
  • [MeSH-minor] Appendix / pathology. Appendix / surgery. Cecum / pathology. Cecum / surgery. Diagnosis, Differential. Humans. Male. Middle Aged. Neoplasm Staging. Rupture, Spontaneous

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  • (PMID = 16774049.001).
  • [ISSN] 1661-8157
  • [Journal-full-title] Praxis
  • [ISO-abbreviation] Praxis (Bern 1994)
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Switzerland
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31. Stojanović I, Karamehmedović Z, Elgazwi K, Baća I: Laparoscopic treatment of cystadenocarcinoma of the appendix penetrating in the sigmoid colon. JSLS; 2009 Jul-Sep;13(3):445-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Laparoscopic treatment of cystadenocarcinoma of the appendix penetrating in the sigmoid colon.
  • Adenocarcinoma of the vermiform appendix is a rare neoplasm of the gastrointestinal tract that most commonly presents as right lower abdominal pain, mimicking acute appendicitis.
  • An accurate and complete preoperative diagnosis has been rare in the past; however, modern imaging techniques allow recognition of most complications and associated conditions.
  • The diagnosis is confirmed postoperatively.

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  • (PMID = 19793493.001).
  • [ISSN] 1086-8089
  • [Journal-full-title] JSLS : Journal of the Society of Laparoendoscopic Surgeons
  • [ISO-abbreviation] JSLS
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
  • [Other-IDs] NLM/ PMC3015953
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32. Khanna M, Buddhavarapu SR: Primary Burkitt's Lymphoma Of The Appendix Presenting As Acute Abdomen: A Case Report. J Radiol Case Rep; 2008;2(5):9-14
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  • [Title] Primary Burkitt's Lymphoma Of The Appendix Presenting As Acute Abdomen: A Case Report.
  • Leukemic and lymphomatous involvement of the appendix is rare and even rarer is its presentation as appendicitis.
  • Burkitt's lymphoma is a high grade B-cell neoplasm.
  • This rapidly growing tumour may cause symptoms due to mass effect or direct involvement of the bowel.
  • Clinical presentations like acute abdomen can be secondary to intestinal obstruction, intussusception or sometimes perforation.We describe here a case of an adult male with an unusual presentation of appendiceal Burkitt's lymphoma mimicking acute cholecystitis or appendicitis.

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  • (PMID = 22470604.001).
  • [ISSN] 1943-0922
  • [Journal-full-title] Journal of radiology case reports
  • [ISO-abbreviation] J Radiol Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3303244
  • [Keywords] NOTNLM ; Appendicitis / Appendix / Burkitt’s lymphoma / CT / Cholecystitis / Lymphoma
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33. Greco L, Papa U: [Mucinous cystoadenocarcinoma of the appendix. A case report]. Ann Ital Chir; 2006 Jul-Aug;77(4):355-8
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  • [Title] [Mucinous cystoadenocarcinoma of the appendix. A case report].
  • [Transliterated title] Il mucocele maligno dell'appendice vermiforme. Descrizione di un caso.
  • CASE REPORT: The Authors report a case of a 66-years-old male patient with mucinous cystoadenocarcinoma of the appendix.
  • Preoperative diagnosis was appendiceal mucocele.
  • At laparatomy was revealed the presence of a large mass of the appendix involving the caecum.
  • Hystology revealed diagnosis of mucinous cystoadenocarcinoma of the appendix.
  • After two weeks patient underwent right hemicolectomy, he is alive without disease at 36 months follow up.
  • Mucinous cystic neoplasms of the appendix is an uncommon disease that is rarely suspected before surgery.
  • The role of chemotherapy in the treatment of patients with appendiceal cancers remains controversial.
  • All patients with any form of appendiceal tumor appear to have an increased incidence of synchronous and metachronous neoplasms, especially in the gastrointestinal tract, and should be investigated and followed up appropriately.
  • [MeSH-major] Appendiceal Neoplasms. Cystadenocarcinoma, Mucinous

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  • (PMID = 17139968.001).
  • [ISSN] 0003-469X
  • [Journal-full-title] Annali italiani di chirurgia
  • [ISO-abbreviation] Ann Ital Chir
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
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34. Tang LH, Shia J, Soslow RA, Dhall D, Wong WD, O'Reilly E, Qin J, Paty P, Weiser MR, Guillem J, Temple L, Sobin LH, Klimstra DS: Pathologic classification and clinical behavior of the spectrum of goblet cell carcinoid tumors of the appendix. Am J Surg Pathol; 2008 Oct;32(10):1429-43
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pathologic classification and clinical behavior of the spectrum of goblet cell carcinoid tumors of the appendix.
  • Appendiceal tumors exhibiting both neuroendocrine and glandular differentiation are uncommon and have caused difficulty in pathologic classification, prediction of prognosis, and clinical management.
  • In this study, we undertook a retrospective investigation of 63 such cases and classified them as typical GCC (group A) and adenocarcinoma ex GCC on the basis of the histologic features of the tumor at the primary site.
  • The clinical characteristics and prognosis were compared within these groups and with conventional de novo appendiceal adenocarcinomas.
  • Both groups A and B tumors shared a similar immunoprofile, which included generally focal immunoreactivity for neuroendocrine markers, and a normal intestinal type mucin glycoprotein profile (negative MUC1 expression and preserved MUC2 immunoreactivity).
  • The proliferative index was relatively low in these tumors and slightly increased from groups A to B tumors (11% to 16%).
  • Both beta-catenin and E-cadherin exhibited a normal membranous staining pattern in groups A and B tumors.
  • The overall disease-specific survival for all subtypes was 77%, with 46% of patients without evidence of disease and 31% alive with disease.
  • All the patients with clinical stage of I or IIA disease had a favorable outcome after appropriate surgery with or without chemotherapy.
  • Although most patients (63%) with GCC presented at an advanced clinical stage, their clinical outcome could be differentiated by subclassification of tumors.
  • In conclusion, GCC is a distinctive appendiceal neoplasm that exhibits unique pathologic features and clinical behavior.
  • [MeSH-major] Adenocarcinoma / pathology. Appendiceal Neoplasms / pathology. Carcinoid Tumor / pathology. Carcinoma, Signet Ring Cell / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antineoplastic Agents / therapeutic use. Appendectomy. Cell Differentiation. Cell Proliferation. Chemotherapy, Adjuvant. Colectomy. Disease-Free Survival. Female. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Neoplasm Staging. Observer Variation. Retrospective Studies. Terminology as Topic. Time Factors. Treatment Outcome


35. Kleemann M, Laubert T, Krokowski M, Eckmann C, Bruch HP, Kujath P: [Mucocele of the appendix - a heterogenous surgical pathology]. Zentralbl Chir; 2010 Aug;135(4):330-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Mucocele of the appendix - a heterogenous surgical pathology].
  • [Transliterated title] Die Mukozele der Appendix - eine inhomogene chirurgische Krankheitsentität.
  • BACKGROUND: Mucoceles of the appendix are rare.
  • Surgical resection is the curative approach for mucoceles of the appendix.
  • MATERIALS AND METHODS: Data of patients who were treated for an appendiceal mucocele between 1995 and 2009 were analysed retrospectively with regard to clinical presentation, diagnostic measures, surgical procedure and histopathological result.
  • In one patient the diagnosis of an appendiceal mucocele was stated preoperatively and in another intraoperatively.
  • CONCLUSIONS: Mucoceles of the appendix present with a wide spectrum of clinical symptoms and histopathological alterations.
  • This study emphasises that a mucocele of the appendix constitutes an important differential diagnosis in patients presenting with pathologies in their right lower abdominal quadrant.
  • [MeSH-major] Appendectomy. Appendiceal Neoplasms / pathology. Appendiceal Neoplasms / surgery. Appendicitis / pathology. Appendicitis / surgery. Cystadenocarcinoma, Mucinous / pathology. Cystadenocarcinoma, Mucinous / surgery. Cystadenoma, Mucinous / pathology. Cystadenoma, Mucinous / surgery. Mucocele / pathology. Mucocele / surgery. Peritoneal Neoplasms / etiology. Pseudomyxoma Peritonei / etiology
  • [MeSH-minor] Aged. Appendix / pathology. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasms, Multiple Primary / pathology. Neoplasms, Multiple Primary / surgery. Neoplasms, Multiple Primary / ultrastructure. Ovarian Neoplasms / pathology. Ovarian Neoplasms / surgery. Ovarian Neoplasms / ultrasonography. Ovariectomy. Ovary / pathology. Precancerous Conditions / pathology. Precancerous Conditions / surgery. Precancerous Conditions / ultrasonography. Retrospective Studies. Rupture, Spontaneous. Young Adult

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  • [Copyright] Georg Thieme Verlag Stuttgart ˙ New York.
  • (PMID = 19998220.001).
  • [ISSN] 1438-9592
  • [Journal-full-title] Zentralblatt für Chirurgie
  • [ISO-abbreviation] Zentralbl Chir
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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36. Sugarbaker PH: Epithelial appendiceal neoplasms. Cancer J; 2009 May-Jun;15(3):225-35
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epithelial appendiceal neoplasms.
  • The appendiceal malignancies usually arise within a mucocele.
  • The tumor within this structure can be minimally aggressive or of an invasive character.
  • If a low-grade appendiceal malignancy is removed intact, recurrence does not occur.
  • If rupture of the wall of the mucocele occurs with either low-grade or high-grade disease, the epithelial cells within will disseminate to the peritoneal surfaces.
  • If the diagnosis of peritoneal dissemination of an appendiceal malignancy has been established, a new treatment with curative intent is indicated.
  • In approximately 900 patients treated at the Washington Cancer Institute, the quantitative prognostic indicators for appendiceal cancer with peritoneal dissemination have been determined.
  • Patients with a complete cytoreduction and low-grade tumor have an 80% survival at 20 years; with high-grade tumors, the survival drops to approximately 45%.
  • The extent of malignancy present within the abdomen by the peritoneal cancer index has a significant impact on survival for both high-grade and low-grade disease.
  • The most important indicator is the completeness of cytoreduction; for both high-grade and low-grade disease, all patients with an incomplete cytoreduction have died by 10 years.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Peritoneal Neoplasms / secondary

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  • (PMID = 19556909.001).
  • [ISSN] 1528-9117
  • [Journal-full-title] Cancer journal (Sudbury, Mass.)
  • [ISO-abbreviation] Cancer J
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 25
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37. Couvelard A: [Appendicular pathology. Mixed endocrine carcinoma with poorly differentiated large cell component]. Ann Pathol; 2010 Apr;30(2):124-9
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  • [Transliterated title] Pathologie de l'appendice. Cas no 7. Carcinome endocrine mixte avec contingent peu différencié à grandes cellules.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Appendicitis / etiology. Appendix / pathology. Carcinoma, Large Cell / pathology. Carcinoma, Neuroendocrine / pathology
  • [MeSH-minor] Adult. Antigens, CD56 / analysis. Appendectomy. Biomarkers, Tumor / analysis. Cell Differentiation. Female. Humans. Ki-67 Antigen / analysis. Lymphatic Metastasis. Neoplasm Proteins / analysis. Synaptophysin / analysis. Tumor Suppressor Protein p53 / analysis

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  • (PMID = 20451071.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Antigens, CD56; 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / Neoplasm Proteins; 0 / Synaptophysin; 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53
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38. Niederle MB, Hackl M, Kaserer K, Niederle B: Gastroenteropancreatic neuroendocrine tumours: the current incidence and staging based on the WHO and European Neuroendocrine Tumour Society classification: an analysis based on prospectively collected parameters. Endocr Relat Cancer; 2010 Dec;17(4):909-18
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  • [Title] Gastroenteropancreatic neuroendocrine tumours: the current incidence and staging based on the WHO and European Neuroendocrine Tumour Society classification: an analysis based on prospectively collected parameters.
  • Using the current WHO classification, the tumor, nodes, metastases (TNM) staging and Ki67 grading and the standard diagnostic procedure proposed by the European Neuroendocrine Tumor Society (ENETS), GEP-NETs from 285 patients (male: 148; female: 137) were recorded.
  • The stomach (23%) was the main site, followed by appendix (21%), small intestine (15%) and rectum (14%).
  • Patients with appendiceal tumours were significantly younger than patients with tumours in any other site.
  • [MeSH-major] Gastrointestinal Neoplasms / pathology. Neuroendocrine Tumors / pathology. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Adult. Age Factors. Austria / epidemiology. Female. Histocytochemistry. Humans. Incidence. Male. Middle Aged. Neoplasm Staging / methods. Prospective Studies

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  • (PMID = 20702725.001).
  • [ISSN] 1479-6821
  • [Journal-full-title] Endocrine-related cancer
  • [ISO-abbreviation] Endocr. Relat. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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39. Onda M, Beers R, Xiang L, Nagata S, Wang QC, Pastan I: An immunotoxin with greatly reduced immunogenicity by identification and removal of B cell epitopes. Proc Natl Acad Sci U S A; 2008 Aug 12;105(32):11311-6
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  • Recombinant immunotoxins are hybrid proteins composed of an Fv that binds to a tumor antigen fused to a bacterial or plant toxin.
  • In marked contrast, only minor responses have been observed in trials with immunotoxins targeting solid tumors, because only a single treatment cycle can be given before antibodies develop.
  • The new immunotoxin (HA22-8X) is significantly less immunogenic in three strains of mice, yet retains full cytotoxic and anti-tumor activities.

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  • (PMID = 18678888.001).
  • [ISSN] 1091-6490
  • [Journal-full-title] Proceedings of the National Academy of Sciences of the United States of America
  • [ISO-abbreviation] Proc. Natl. Acad. Sci. U.S.A.
  • [Language] ENG
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies; 0 / Bacterial Toxins; 0 / Enterotoxins; 0 / Epitopes, B-Lymphocyte; 0 / Exotoxins; 0 / RFB4(dsFv)-PE38 recombinant immunotoxin; 0 / Recombinant Fusion Proteins; 0 / Virulence Factors; EC 2.4.2.- / ADP Ribose Transferases; EC 2.4.2.31 / toxA protein, Pseudomonas aeruginosa
  • [Other-IDs] NLM/ PMC2516223
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40. Kuester D, Dalicho S, Mönkemüller K, Benedix F, Lippert H, Guenther T, Roessner A, Meyer F: Synchronous multifocal colorectal carcinoma in a patient with delayed diagnosis of ulcerative pancolitis. Pathol Res Pract; 2008;204(12):905-10
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  • [Title] Synchronous multifocal colorectal carcinoma in a patient with delayed diagnosis of ulcerative pancolitis.
  • Relatively often, the patients present with multiple synchronous or metachronous tumors.
  • Regardless of the diagnosis and medical advice, the patient initially refused therapy, and proctocolectomy was delayed for 12 months.
  • At the time of colectomy, advanced tumor stage was diagnosed and classified as pT3c(4) pN1(2/120) M0 V1 R0, UICC stage IIIB, G2.
  • Furthermore, a mucinous cystadenoma was found in the appendix in the setting of ulcerative colitis.
  • [MeSH-major] Adenocarcinoma / pathology. Colitis, Ulcerative / complications. Colitis, Ulcerative / pathology. Colorectal Neoplasms / pathology
  • [MeSH-minor] Adult. Appendiceal Neoplasms / pathology. Cystadenoma, Mucinous / pathology. Humans. Male. Neoplasm Staging. Neoplasms, Multiple Primary / pathology

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  • [CommentIn] Zentralbl Chir. 2015 Dec;140(6):624-6 [25076166.001]
  • (PMID = 18842350.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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41. Basic-Jukic N, Furic-Cunko V, Coric M, Bubic-Filipi LJ, Kastelan Z, Pasini J, Kes P: Appendiceal carcinoid and mucinous cystadenoma in renal transplant recipients: case reports. Transplant Proc; 2010 Jun;42(5):1704-7
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  • [Title] Appendiceal carcinoid and mucinous cystadenoma in renal transplant recipients: case reports.
  • There is an increased incidence of tumors among renal transplant patients, which are associated with immunosuppression.
  • Carcinoids are rare neuroendocrine tumors that arise from the enterochromaffin cells.
  • Although appendiceal carcinoid tumors are the commonest malignant neoplasms affecting the appendix, and mucinous cystadenoma is the commonest benign appendiceal neoplasm, they have not been reported in immunosuppressed patients.
  • We present two renal transplant recipients who developed combined appendiceal carcinoid and mucinous cystadenoma.
  • [MeSH-major] Appendiceal Neoplasms / etiology. Cystadenoma, Mucinous / etiology. Kidney Transplantation / adverse effects
  • [MeSH-minor] Adult. Female. Humans. Kidney Failure, Chronic / surgery. Magnetic Resonance Imaging. Male. Neoplasms / epidemiology. Neoplasms / etiology. Neoplasms / pathology. Neoplasms / surgery. Ovarian Neoplasms / pathology. Ovarian Neoplasms / surgery

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  • (PMID = 20620505.001).
  • [ISSN] 1873-2623
  • [Journal-full-title] Transplantation proceedings
  • [ISO-abbreviation] Transplant. Proc.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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42. Sugarbaker PH, Bijelic L, Chang D, Yoo D: Neoadjuvant FOLFOX chemotherapy in 34 consecutive patients with mucinous peritoneal carcinomatosis of appendiceal origin. J Surg Oncol; 2010 Nov 1;102(6):576-81
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  • [Title] Neoadjuvant FOLFOX chemotherapy in 34 consecutive patients with mucinous peritoneal carcinomatosis of appendiceal origin.
  • BACKGROUND: A treatment option for patients with peritoneal mucinous carcinomatosis (PMCA) from an appendiceal neoplasm is cytoreductive surgery and perioperative intraperitoneal chemotherapy.
  • METHODS: In January of 2005 a prospective study was initiated to routinely treat patients with peritoneal dissemination of a mucinous adenocarcinoma of the appendix with neoadjuvant chemotherapy using FOLFOX.
  • In the clinical evaluation and CT evaluation, 24 (71%) and 22 (65%), respectively, had stable disease on chemotherapy.
  • [MeSH-major] Adenocarcinoma, Mucinous / drug therapy. Adenocarcinoma, Mucinous / secondary. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Appendiceal Neoplasms / pathology. Peritoneal Neoplasms / drug therapy. Peritoneal Neoplasms / secondary

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  • (PMID = 20737420.001).
  • [ISSN] 1096-9098
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; Folfox protocol
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43. Tannapfel A, Wittekind C: [The current TNM system for gastrointestinal tumors part II]. Pathologe; 2010 Sep;31(5):348-52
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  • [Title] [The current TNM system for gastrointestinal tumors part II].
  • [Transliterated title] Aktuelles TNM-System der gastrointestinalen Tumoren Teil II.
  • Major and praxis-relevant alterations concern colorectal tumours and include new classifications of carcinomas and carcinoids of the appendix.
  • [MeSH-major] Digestive System Neoplasms / pathology. Neoplasm Staging / methods
  • [MeSH-minor] Ampulla of Vater / pathology. Appendiceal Neoplasms / classification. Appendiceal Neoplasms / pathology. Carcinoid Tumor / classification. Carcinoid Tumor / pathology. Carcinoma, Hepatocellular / classification. Carcinoma, Hepatocellular / pathology. Cholangiocarcinoma / classification. Cholangiocarcinoma / pathology. Colorectal Neoplasms / classification. Colorectal Neoplasms / pathology. Common Bile Duct Neoplasms / pathology. Disease Progression. Gallbladder Neoplasms / classification. Gallbladder Neoplasms / pathology. Gastrointestinal Stromal Tumors / classification. Gastrointestinal Stromal Tumors / pathology. Humans. Lymphatic Metastasis / pathology. Mitotic Index. Neoplasm Invasiveness / pathology. Neuroendocrine Tumors / classification. Neuroendocrine Tumors / pathology. Pancreatic Neoplasms / classification. Pancreatic Neoplasms / pathology. Prognosis. Rectal Neoplasms / classification. Rectal Neoplasms / pathology

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  • [CommentIn] Pathologe. 2010 Sep;31(5):353-4 [20809402.001]
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  • (PMID = 20798945.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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44. Ikeura T, Takaoka M, Shimatani M, Koyabu M, Kusuda T, Suzuki R, Sumimoto K, Okazaki K: Xanthogranulomatous inflammation of the peripancreatic region mimicking pancreatic cystic neoplasm. Intern Med; 2009;48(21):1881-4
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  • [Title] Xanthogranulomatous inflammation of the peripancreatic region mimicking pancreatic cystic neoplasm.
  • Herein, we report a case of a 73-year-old man without symptoms who was initially diagnosed with a pancreatic cystic tumor but later with XGI in the peripancreatic region.
  • Although XGI has been reported to occur in various organs or tissues, such as the gallbladder, kidney, bone, stomach, colon, appendix, lymph nodes, and soft tissues, XGI involving the pancreas or its surrounding tissues is extremely rare.
  • When a pancreatic cystic lesion does not have typical clinicoradiological features of common pancreatic cystic neoplasms, this pathologic condition should be considered in the differential diagnosis.
  • [MeSH-major] Histiocytes / pathology. Inflammation / diagnosis. Neoplasms, Cystic, Mucinous, and Serous / diagnosis. Pancreatic Diseases / diagnosis. Pancreatic Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male. Pancreatectomy

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  • (PMID = 19881238.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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45. Ushida H, Masuda Y, Yoshida T, Okada Y: [Self-catheterizable urinary re-diversion using the appendix for urethral recurrence after ileal neobladder]. Hinyokika Kiyo; 2008 Nov;54(11):749-52
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  • [Title] [Self-catheterizable urinary re-diversion using the appendix for urethral recurrence after ileal neobladder].
  • Transurethral resection of bladder tumor was performed and pathological findings showed transitional cell carcinoma (TCC), papillary invasive G3, pT1 or more.
  • Finally, we performed total urethrectomy and partial resection of bladder neck with self-catheterizable urinary rediversion using appendix.
  • Self-catheterizable urinary re-diversion using the appendix can be an option for urethral recurrence after ileal neobladder reconstruction.
  • [MeSH-major] Appendix / transplantation. Carcinoma, Transitional Cell / surgery. Self Care. Urethra / surgery. Urinary Bladder Neoplasms / surgery. Urinary Catheterization. Urinary Diversion / methods
  • [MeSH-minor] Aged. Humans. Male. Neoplasm Recurrence, Local. Neoplasm Staging. Reoperation. Urinary Bladder / surgery

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  • (PMID = 19068732.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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46. Palanivelu C, Rangarajan M, John SJ, Senthilkumar K, Annapoorni S: Laparoscopic right hemicolectomy for mucocele due to a low-grade appendiceal mucinous neoplasm. JSLS; 2008 Apr-Jun;12(2):194-7
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  • [Title] Laparoscopic right hemicolectomy for mucocele due to a low-grade appendiceal mucinous neoplasm.
  • Tumors of the appendix are rare entities causing mucoceles.
  • Laparoscopic surgery for appendiceal tumors is still controversial, as inadvertent rupture of the lesion due to improper handling will cause pseudomyxoma peritonei.
  • The patient was incidentally discovered to have an appendiceal tumor and referred to us for laparoscopy.
  • Because the tumor involved the entire appendix, a laparoscopic right hemicolectomy was performed without directly handling the tumor.
  • Pathological diagnosis was low-grade appendiceal mucinous neoplasm.
  • The safety of laparoscopic appendectomy for the management of incidentally discovered appendiceal tumors has not yet been established.
  • The main concerns to be addressed are the adequacy of resection and intraperitoneal rupture of the tumor.
  • A formal right hemicolectomy was performed because the tumor involved the entire appendix.
  • We now think laparoscopic surgery for appendiceal tumors is safe, feasible, and even may be beneficial.

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  • (PMID = 18435897.001).
  • [ISSN] 1086-8089
  • [Journal-full-title] JSLS : Journal of the Society of Laparoendoscopic Surgeons
  • [ISO-abbreviation] JSLS
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3016193
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47. Garcia-Carbonero R, Capdevila J, Crespo-Herrero G, Díaz-Pérez JA, Martínez Del Prado MP, Alonso Orduña V, Sevilla-García I, Villabona-Artero C, Beguiristain-Gómez A, Llanos-Muñoz M, Marazuela M, Alvarez-Escola C, Castellano D, Vilar E, Jiménez-Fonseca P, Teulé A, Sastre-Valera J, Benavent-Viñuelas M, Monleon A, Salazar R: Incidence, patterns of care and prognostic factors for outcome of gastroenteropancreatic neuroendocrine tumors (GEP-NETs): results from the National Cancer Registry of Spain (RGETNE). Ann Oncol; 2010 Sep;21(9):1794-803
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  • [Title] Incidence, patterns of care and prognostic factors for outcome of gastroenteropancreatic neuroendocrine tumors (GEP-NETs): results from the National Cancer Registry of Spain (RGETNE).
  • BACKGROUND: Neuroendocrine tumors (NETs) are an unusual family of neoplasms with a wide and complex spectrum of clinical behavior.
  • Here, we present the first report of a National Cancer Registry of gastroenteropancreatic neuroendocrine tumors from a Southern European country.
  • RESULTS: The study cohort comprised 907 tumors.
  • The most common tumor types were carcinoids (55%), pancreatic nonfunctional tumors (20%), metastatic NETs of unknown primary (9%), insulinomas (8%) and gastrinomas (4%).
  • Forty-four percent presented with distant disease at diagnosis, most often those from small intestine (65%), colon (48%), rectum (40%) and pancreas (38%), being most unusual in appendix primaries (1.3%).
  • Stage at diagnosis varied significantly according to sex, localization of primary tumor, tumor type and grade.
  • Overall 5-year survival was 75.4% (95% confidence interval 71.3% to 79.5%) and was significantly greater in women, younger patients and patients with hormonal syndrome and early stage or lower grade tumors.
  • Prognosis also differed according to tumor type and primary tumor site.
  • CONCLUSION: This national database reveals relevant information regarding epidemiology, current clinical practices and prognosis of NETs in Spain, providing valuable insights that may contribute to understand regional disparities in the incidence, patterns of care and survival of this heterogeneous disease across different continents and countries.

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  • (PMID = 20139156.001).
  • [ISSN] 1569-8041
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
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48. Yajima N, Wada R, Yamagishi S, Mizukami H, Itabashi C, Yagihashi S: Immunohistochemical expressions of cytokeratins, mucin core proteins, p53, and neuroendocrine cell markers in epithelial neoplasm of appendix. Hum Pathol; 2005 Nov;36(11):1217-25
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  • [Title] Immunohistochemical expressions of cytokeratins, mucin core proteins, p53, and neuroendocrine cell markers in epithelial neoplasm of appendix.
  • Epithelial neoplasms of appendix are infrequent, and their pathological features are not fully characterized.
  • We collected 33 cases of appendiceal tumors and examined immunohistochemically the expression of cytokeratins (CK, CK7, and CK20), mucin core protein (MUC1, MUC2, MUC5AC, and MUC6), E-cadherin, chromogranin A, and p53 protein.
  • Clinically, mucinous tumors were predominant in females.
  • Immunohistochemically, all the tumors expressed CK20, whereas CK7 was positive in one third of the cases.
  • Similarly, MUC2 was expressed in all the tumors, whereas MUC1 and MUC5AC were detected in about a half of the cases.
  • Although chromogranin A-positive cells are generally sparse in normal appendix, they were more common in mucinous tumors than in nonmucinous tumors.
  • Contrary to the previous data reported (Mod Pathol 2002;15:599-605), mucinous carcinoma exhibited a higher frequency of p53-positive cells (mean 29%) compared with mucinous adenoma (2.8%) (P < .001), whereas nonmucinous tumors showed high levels of p53-positive cells to similar extent (51%-67%) in both adenoma and carcinoma.
  • The high expression of p53 protein coincided with the presence of mutations in multiple sites of TP53 gene in mucinous tumors.
  • This is the first report that characterized the immunophenotypic profile of appendiceal epithelial neoplasms with an emphasis of a higher frequency of p53 positivity in mucinous carcinoma cases compared with mucinous adenoma in the appendix.
  • [MeSH-major] Appendiceal Neoplasms / metabolism. Biomarkers, Tumor / analysis. Keratins / biosynthesis. Mucins / biosynthesis. Neoplasms, Glandular and Epithelial / metabolism. Tumor Suppressor Protein p53 / biosynthesis


49. Yoon WJ, Yoon YB, Kim YJ, Ryu JK, Kim YT: Metastasis to the gallbladder: a single-center experience of 20 cases in South Korea. World J Gastroenterol; 2009 Oct 14;15(38):4806-9
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  • The primary malignancies originated from the stomach (n = 8), colorectum (n = 3), liver (n = 2), kidney (n = 2), skin (n = 2), extrahepatic bile duct (n = 1), uterine cervix (n = 1), and appendix (n = 1).
  • The median survival after the diagnosis of MGB was 8.7 mo.
  • [MeSH-major] Gallbladder Neoplasms / secondary. Neoplasms / pathology
  • [MeSH-minor] Abdominal Pain / diagnosis. Adult. Aged. CA-19-9 Antigen / biosynthesis. Cholecystitis / diagnosis. Female. Humans. Jaundice / diagnosis. Male. Middle Aged. Neoplasm Metastasis. Proportional Hazards Models. Republic of Korea. Retrospective Studies. Weight Loss / drug effects

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  • [Cites] Am Surg. 2007 Aug;73(8):833-5 [17879698.001]
  • [Cites] World J Surg Oncol. 2007;5:101 [17848197.001]
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  • (PMID = 19824115.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / CA-19-9 Antigen
  • [Other-IDs] NLM/ PMC2761559
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50. Piura B, Rabinovich A, Apel-Sarid L, Shaco-Levy R: Carcinosarcoma of the fallopian tube with metastasis of its epithelial component to the ovary, appendix and omentum. J Obstet Gynaecol; 2009 Aug;29(6):566-7
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  • [Title] Carcinosarcoma of the fallopian tube with metastasis of its epithelial component to the ovary, appendix and omentum.
  • [MeSH-major] Carcinosarcoma / pathology. Fallopian Tube Neoplasms / pathology. Fallopian Tubes / pathology
  • [MeSH-minor] Aged. Appendix / pathology. Female. Humans. Neoplasm Metastasis. Omentum / pathology. Ovary / pathology

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  • (PMID = 19697224.001).
  • [ISSN] 1364-6893
  • [Journal-full-title] Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology
  • [ISO-abbreviation] J Obstet Gynaecol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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51. Okita A, Kubo Y, Tanada M, Kurita A, Takashima S: Unusual abscesses associated with colon cancer: report of three cases. Acta Med Okayama; 2007 Apr;61(2):107-13
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  • Case I : A 77-year-old man was diagnosed with a paracolic abscess formation behind the cecum and a swollen appendix by computed tomography (CT) scan.
  • Case II : An 85-year-old woman was diagnosed with an abscess formation of the right iliopsoas muscle, a swollen appendix, and a thickened right colon wall by CT scan.
  • After antibiotic therapy failed, both patients underwent ileocecal resection urgently under suspicion of appendicitis, but cecal cancer around the entrance to the appendix caused secondary appendicitis in both cases.
  • Case III : A 50-year-old woman was diagnosed with sigmoid colon cancer with an abscess formation in the pelvic cavity concomitant with ovarian tumor.
  • We emphasize that precise surgical evaluation has an important role in the diagnosis of these complicated diseases.
  • [MeSH-major] Abscess / etiology. Colonic Neoplasms / complications
  • [MeSH-minor] Aged. Aged, 80 and over. Appendicitis / diagnostic imaging. Appendicitis / etiology. Cecal Neoplasms / complications. Female. Humans. Intestinal Perforation / etiology. Male. Middle Aged. Muscular Diseases / complications. Muscular Diseases / etiology. Muscular Diseases / surgery. Neoplasm Recurrence, Local. Ovarian Neoplasms / complications. Pelvis. Radiography, Abdominal. Rectum. Sigmoid Neoplasms / complications. Sigmoid Neoplasms / diagnostic imaging. Sigmoid Neoplasms / surgery. Tomography, X-Ray Computed

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  • (PMID = 17471312.001).
  • [ISSN] 0386-300X
  • [Journal-full-title] Acta medica Okayama
  • [ISO-abbreviation] Acta Med. Okayama
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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52. Yemelyanova AV, Vang R, Judson K, Wu LS, Ronnett BM: Distinction of primary and metastatic mucinous tumors involving the ovary: analysis of size and laterality data by primary site with reevaluation of an algorithm for tumor classification. Am J Surg Pathol; 2008 Jan;32(1):128-38
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  • [Title] Distinction of primary and metastatic mucinous tumors involving the ovary: analysis of size and laterality data by primary site with reevaluation of an algorithm for tumor classification.
  • Distinction of primary ovarian mucinous tumors from metastatic/secondary mucinous tumors involving the ovaries is often challenging, not only at the time of intraoperative assessment when requested for surgical management (staging decisions) but also for final pathologic diagnosis.
  • Previous studies have shown that a simple algorithm using tumor size and laterality (bilateral tumors of any size, or unilateral tumor <10 cm=metastatic; unilateral tumor > or =10 cm=primary) can accurately classify a substantial majority of tumors.
  • To assess the general utility of this algorithm for distinction of primary and secondary mucinous tumors in the ovary and address the occurrence of exceptions (large unilateral metastases), analysis of tumor size and laterality data was performed using 194 tumors (52 primary tumors and 142 metastases), with metastases subclassified by primary site [colorectum (46), appendix (28 low-grade tumors, 20 carcinomas), pancreaticobiliary tract (20), small intestine (3), stomach (5), and endocervix (20)].
  • Performance of the algorithm was evaluated using the originally proposed method and modified size criteria were analyzed to optimize tumor classification.
  • The original algorithm correctly classified 84% of tumors overall, including 100% of primary ovarian tumors and 77% of all metastases (colorectal: 74%; appendiceal: 79% of low-grade tumors, 100% of carcinomas; pancreaticobiliary: 95%; small intestinal: 33%; gastric: 80%; endocervical: 55%).
  • By adjusting the size criterion to 12 cm, performance of the algorithm was both maintained for primary ovarian tumors and improved for metastases, with correct classification of 86% of tumors overall, including 100% of primary tumors and 80% of metastases.
  • Performance was optimized at 13 cm, with correct classification of 87% of tumors overall, including 98% of primary tumors and 82% of metastases (colorectal: 80%; appendiceal: 79% of low-grade tumors, 100% of carcinomas; pancreaticobiliary: 100%; small intestinal: 33%; gastric: 100%; endocervical: 70%).
  • Recognition that metastatic colorectal carcinomas represent the most common metastases and have a greater tendency to violate the algorithm should prompt lowering of the threshold for suggesting the possibility of metastatic colorectal carcinoma for tumors displaying any microscopic features suggestive of that diagnosis, even when a history of primary colorectal carcinoma is lacking.
  • Use of the algorithm is intended as an adjunct to the complete clinicopathologic evaluation that ideally should occur when problematic mucinous tumors in the ovary are encountered.
  • [MeSH-major] Adenocarcinoma, Mucinous / classification. Algorithms. Neoplasm Metastasis / pathology. Ovarian Neoplasms / classification

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  • (PMID = 18162780.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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53. Srivastava A, Hornick JL: Immunohistochemical staining for CDX-2, PDX-1, NESP-55, and TTF-1 can help distinguish gastrointestinal carcinoid tumors from pancreatic endocrine and pulmonary carcinoid tumors. Am J Surg Pathol; 2009 Apr;33(4):626-32
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  • [Title] Immunohistochemical staining for CDX-2, PDX-1, NESP-55, and TTF-1 can help distinguish gastrointestinal carcinoid tumors from pancreatic endocrine and pulmonary carcinoid tumors.
  • Well-differentiated neuroendocrine tumors (WDNET) of the gastrointestinal tract, pancreas, and lung are histologically similar.
  • In total, 64 gastrointestinal carcinoids (5 stomach; 5 duodenum; 31 ileum; 11 appendix; and 12 rectum); 39 pancreatic endocrine tumors (PET); and 20 pulmonary carcinoid tumors were studied.
  • Appendiceal carcinoids were uniformly positive for CDX-2 (11/11).
  • [MeSH-major] Biomarkers, Tumor / metabolism. Carcinoid Tumor / diagnosis. Gastrointestinal Neoplasms / diagnosis. Lung Neoplasms / diagnosis. Neoplasm Proteins / metabolism. Pancreatic Neoplasms / diagnosis
  • [MeSH-minor] DNA-Binding Proteins / metabolism. Diagnosis, Differential. Fluorescent Antibody Technique, Indirect. GTP-Binding Protein alpha Subunits, Gs / metabolism. Homeodomain Proteins / metabolism. Humans. Immunoenzyme Techniques. Trans-Activators / metabolism

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  • (PMID = 19065104.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / Homeodomain Proteins; 0 / Neoplasm Proteins; 0 / TTF1 protein, human; 0 / Trans-Activators; 0 / pancreatic and duodenal homeobox 1 protein; 156560-97-3 / Cdx-2-3 protein; EC 3.6.1.- / GNAS protein, human; EC 3.6.5.1 / GTP-Binding Protein alpha Subunits, Gs
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54. Lepistö A, Osterlund P, Järvinen HJ: [Treatment of pseudomyxoma peritonei is developing]. Duodecim; 2010;126(14):1693-9
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  • In pseudomyxoma peritonei a mucinous tumor of the appendix spreads into the abdominal cavity.
  • Cytologic picture of the tumor may be benign, malignant or intermediary.
  • The symptoms were previously relieved by repeated resections of the tumor mass, whereby even the most benign form of the disease progressed slowly.
  • [MeSH-major] Peritoneal Neoplasms / drug therapy. Peritoneal Neoplasms / surgery. Pseudomyxoma Peritonei / drug therapy. Pseudomyxoma Peritonei / surgery
  • [MeSH-minor] Antineoplastic Agents / administration & dosage. Appendix / pathology. Combined Modality Therapy. Disease Progression. Humans. Neoplasm Invasiveness. Therapeutic Irrigation / methods

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  • (PMID = 20804088.001).
  • [ISSN] 0012-7183
  • [Journal-full-title] Duodecim; lääketieteellinen aikakauskirja
  • [ISO-abbreviation] Duodecim
  • [Language] fin
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Finland
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 22
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55. Moreno Gijón M, Granero Castro P, Fernández García MS, Vázquez Velasco L, González González JJ: [Granular cell tumor of the appendix]. Rev Esp Enferm Dig; 2009 Jul;101(7):512-3
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  • [Title] [Granular cell tumor of the appendix].
  • [Transliterated title] Tumor de células granulares apendicular.
  • [MeSH-major] Appendiceal Neoplasms. Granular Cell Tumor

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  • (PMID = 19642848.001).
  • [ISSN] 1130-0108
  • [Journal-full-title] Revista española de enfermedades digestivas : organo oficial de la Sociedad Española de Patología Digestiva
  • [ISO-abbreviation] Rev Esp Enferm Dig
  • [Language] spa
  • [Publication-type] Case Reports; Letter; Review
  • [Publication-country] Spain
  • [Number-of-references] 7
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56. Turan T, Aykan B, Koc S, Boran N, Tulunay G, Karacay O, Erdogan Z, Kose F: Analysis of metastatic ovarian tumors from extragenital primary sites. Tumori; 2006 Nov-Dec;92(6):491-5
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  • [Title] Analysis of metastatic ovarian tumors from extragenital primary sites.
  • AIMS AND BACKGROUND: The aim of this study was to evaluate patients with metastatic ovarian tumors from extragenital primary sites.
  • METHODS: The medical records of 75 patients were reviewed retrospectively for age at diagnosis, presenting symptoms, preoperative tumor marker levels, preoperative diagnostic workup, operative technique, intraoperative evaluation, frozen-section and pathology results, laterality of metastasis, and primary tumor site.
  • The specific impact of metastasis from colorectal and gastric primary sites on laterality, gross features and dimensions of ovarian mass, volume of ascites and tumor marker levels was investigated.
  • RESULTS: Primary sites were stomach (37.3%), colorectal region (28%), lymphoma (12%), breast (6.7%), biliary system (2.7%), appendix (1.3%) and small intestine (1.3%).
  • It was not possible to identify the primary tumor site in 8 (10.7%) patients.
  • Bilateral metastasis was found in 86.4% patients; 42.7% of the metastatic ovarian tumors were Krukenberg tumors; 50.7% of the ovarian masses were solid.
  • The mean preoperative serum levels of tumor markers were 298.7 U/mL, 178 U/mL and 113.3 U/mL for CA 125, CA 19-9 and CA 15-3, respectively.
  • The presence of ascites was more frequent in ovarian tumors originating from colorectal and gastric primaries.
  • CONCLUSIONS: Surgery is essential for the diagnosis of the primary tumor and necessary for relief of symptoms.
  • [MeSH-major] Biomarkers, Tumor / blood. Breast Neoplasms / diagnosis. Digestive System Neoplasms / diagnosis. Lymphoma / diagnosis. Ovarian Neoplasms / secondary
  • [MeSH-minor] Adult. Aged. Ascites / etiology. CA-125 Antigen / blood. CA-19-9 Antigen / blood. Carcinoembryonic Antigen / blood. Female. Frozen Sections. Humans. Middle Aged. Neoplasm Staging. Retrospective Studies. alpha-Fetoproteins / metabolism

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  • (PMID = 17260489.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CA-125 Antigen; 0 / CA-19-9 Antigen; 0 / Carcinoembryonic Antigen; 0 / alpha-Fetoproteins
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57. Wittekind C: [TNM 2010. What's new?]. Pathologe; 2010 Oct;31 Suppl 2:153-60
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  • In the seventh edition of the TNM Classification of Malignant Tumours there are several entirely new classifications: upper aerodigestive mucosal melanoma, gastrointestinal stromal tumour, gastrointestinal carcinoid (neuroendocrine tumour), intrahepatic cholangiocarcinoma, Merkel cell carcinoma, uterine sarcomas, and adrenal cortical carcinoma.
  • Significant modifications concern carcinomas of the oesophagus, oesophagogastric junction, stomach, appendix, biliary tract, lung, skin, prostate and ophthalmic tumours, which will be not addressed in this article.
  • For several tumour entities only minor changes were introduced which might be of importance in daily practice.
  • [MeSH-major] Neoplasm Staging / methods. Neoplasm Staging / trends. Neoplasms / pathology
  • [MeSH-minor] Adrenal Cortex Neoplasms / classification. Adrenal Cortex Neoplasms / pathology. Bile Duct Neoplasms / classification. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic. Carcinoid Tumor / classification. Carcinoid Tumor / pathology. Carcinoma, Merkel Cell / classification. Carcinoma, Merkel Cell / pathology. Cholangiocarcinoma / classification. Cholangiocarcinoma / pathology. Digestive System Neoplasms / classification. Digestive System Neoplasms / pathology. Female. Gastrointestinal Stromal Tumors / classification. Gastrointestinal Stromal Tumors / pathology. Humans. Respiratory Tract Neoplasms / classification. Respiratory Tract Neoplasms / pathology. Sarcoma / classification. Sarcoma / pathology. Skin Neoplasms / classification. Skin Neoplasms / pathology. Uterine Neoplasms / classification. Uterine Neoplasms / pathology

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  • (PMID = 20737151.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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58. Goere D, Elias D: [Appendiceal tumors found at appendectomy]. J Chir (Paris); 2009 Oct;146 Spec No 1:36-8
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  • [Title] [Appendiceal tumors found at appendectomy].
  • [Transliterated title] Diagnostic de tumeur appendiculaire lors d'une appendicectomie.
  • There are three main histologic types of appendiceal tumor: adenoma, adenocarcinoma, and neuroendocrine tumor.
  • Neuroendocrine tumors (carcinoids) are by far the most common and account for two-third of all appendiceal tumors.
  • Rupture of any mucinous tumor-whether spontaneous or occurring during surgery-may result in pseudomyxoma peritonei; treatment of this condition requires complete resection of all lesions followed by hyperthermic intraperitoneal chemotherapy.
  • For unruptured appendiceal tumor, the appendix should be removed by a carcinologic right hemicolectomy if the tumor appears aggressive.
  • [MeSH-major] Appendectomy. Appendiceal Neoplasms / surgery
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / surgery. Adenoma / diagnosis. Adenoma / surgery. Humans. Neuroendocrine Tumors / diagnosis. Neuroendocrine Tumors / surgery. Peritoneal Neoplasms / prevention & control. Pseudomyxoma Peritonei / prevention & control. Rupture / prevention & control

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  • (PMID = 19846099.001).
  • [ISSN] 0021-7697
  • [Journal-full-title] Journal de chirurgie
  • [ISO-abbreviation] J Chir (Paris)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 7
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59. Zafar S, Chen H, Sun W, Das K: Cytology of metastatic appendiceal goblet cell carcinoid in pleural effusion fluid: a case report. Diagn Cytopathol; 2008 Dec;36(12):894-8
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  • [Title] Cytology of metastatic appendiceal goblet cell carcinoid in pleural effusion fluid: a case report.
  • Goblet cell appendiceal carcinoid (GCAC) is a rare neoplasm.
  • A computed tomography (CT) scan showed a mass involving the base of the appendix, ascites and concomitant pleural effusion.
  • The appendiceal mass was biopsied and diagnosed as a GCAC.
  • [MeSH-major] Appendiceal Neoplasms / diagnosis. Carcinoid Tumor / diagnosis. Pleural Effusion, Malignant / diagnosis
  • [MeSH-minor] Aged. Ascites / diagnosis. Ascites / etiology. Diagnosis, Differential. Humans. Male

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 18855885.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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60. Uchikov A, Genova S, Peshev Zh, Dimov R, Dimitrov I, Murdzhev K: [Carcinoid tumors of the gastrointestinal tract--frequency, organ localization, clinical course, treatment (a presentation of 10 cases)]. Khirurgiia (Sofiia); 2005;(4-5):20-2
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  • [Title] [Carcinoid tumors of the gastrointestinal tract--frequency, organ localization, clinical course, treatment (a presentation of 10 cases)].
  • Carcinoid tumors originate from the argentofile cells found at the bottom of the crypt of Lieberkuhn.
  • In spite of their slow growth and comparatively better prognosis, the carcinoid are malignant tumors, which effective treatment is their surgical resection.
  • We present 10 patients with carcinoid of the gastrointestinal tract (GIT)--3 from small intestine, 3 from large intestine, 2 from appendix, I from rectum and 1 from stomach, operated at our clinic for a 6 year period of time.
  • [MeSH-major] Carcinoid Tumor. Gastrointestinal Neoplasms
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Disease-Free Survival. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Metastasis

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  • (PMID = 18693512.001).
  • [ISSN] 0450-2167
  • [Journal-full-title] Khirurgii︠a︡
  • [ISO-abbreviation] Khirurgiia (Sofiia)
  • [Language] bul
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Bulgaria
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61. Miyazaki K, Satoh H, Sekizawa K: Metastasis to appendix from lung adenocarcinoma. Int J Gastrointest Cancer; 2005;36(1):59-60
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  • [Title] Metastasis to appendix from lung adenocarcinoma.
  • Endoscopic evaluation revealed no obstruction, but failed to identify mucosal abnormalities in the ileocecal region.
  • He underwent a laparotomy, and tumor of the appendix, 3 x 3 cm in diameter, adhered to the surrounding tissue, but no perforation was seen.
  • The mass was excised in combination with an ileocecal resection, followed by ileocolic anastomosis.
  • Hisotologically, the neoplastic tumor cells infiltrated the submucosa, muscularis, and serosa, but mucosa of the appendix was intact, unremarkable, with no precursor lesion.
  • The tumor was morphologically similar to the lung primary tumor.
  • He was examined at regular periodic follow-ups, but died from lung cancer 12 mo after the resection of the metastatic tumor to the appendix.
  • [MeSH-major] Appendiceal Neoplasms / secondary. Lung Neoplasms / pathology

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  • [CommentOn] Int J Gastrointest Cancer. 2003;34(1):55-8 [15235136.001]
  • [Cites] Pathol Int. 1996 Mar;46(3):216-20 [10846573.001]
  • [Cites] Int J Gastrointest Cancer. 2003;34(1):55-8 [15235136.001]
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  • (PMID = 16227637.001).
  • [ISSN] 1537-3649
  • [Journal-full-title] International journal of gastrointestinal cancer
  • [ISO-abbreviation] Int J Gastrointest Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Comment; Journal Article
  • [Publication-country] United States
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62. Bruin SC, Verwaal VJ, Vincent A, van't Veer LJ, van Velthuysen ML: A clinicopathologic analysis of peritoneal metastases of colorectal and appendiceal origin. Ann Surg Oncol; 2010 Sep;17(9):2330-40
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  • [Title] A clinicopathologic analysis of peritoneal metastases of colorectal and appendiceal origin.
  • OBJECTIVE: To predict clinical outcome by classification of peritoneal metastases (PM) of colorectal or appendiceal origin.
  • BACKGROUND: This study investigates whether standardized histological classification can predict outcome for PM of colorectal or appendiceal origin treated with cytoreduction and hyperthermic intraperitoneal chemotherapy (HIPEC).
  • For overall survival (OS) and disease-free survival (DFS) Cox proportional-hazard models were constructed.
  • Covariates included tumor, patient, and treatment characteristics.
  • RESULTS: PM could be categorized into four groups: low-grade, well-differentiated mucinous tumor (DPAM); intermediated-grade mucinous carcinoma (PMCA-i); high-grade mucinous carcinoma (PMCA); and high-grade nonmucinous carcinoma (PCA).
  • Of PM originating from an appendix tumor, 29% were of non-DPAM type.
  • Of primary colorectal tumors, 37% resulted in mucinous PM, and another 26% of PM of colorectal origin had partly mucinous histology.
  • [MeSH-major] Adenocarcinoma, Mucinous / secondary. Appendiceal Neoplasms / pathology. Colorectal Neoplasms / pathology. Peritoneal Neoplasms / secondary
  • [MeSH-minor] Aged. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Neoplasm Staging. Prognosis. Survival Rate

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  • (PMID = 20232161.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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63. Koyama T, Mikami Y, Saga T, Tamai K, Togashi K: Secondary ovarian tumors: spectrum of CT and MR features with pathologic correlation. Abdom Imaging; 2007 Nov;32(6):784-95
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  • [Title] Secondary ovarian tumors: spectrum of CT and MR features with pathologic correlation.
  • The ovaries represent common sites for metastatic disease.
  • The common primary sites for metastatic disease to the ovaries include the colon, stomach, breast, and the genitourinary tract.
  • Ovarian metastasis may occasionally represent the initial manifestation of disease, especially in cancers of the gastrointestinal tract.
  • The accurate diagnosis of this condition is always crucial since the misinterpretation of such tumors may cause significant adverse consequences for patients.
  • CT and MR features of secondary ovarian tumors differ according to the origins of the primary malignancies.
  • The great majority of metastases from gastric cancer are Krukenberg tumors, which are typically bilateral and characterized by lobulated solid tumors.
  • Metastases from colon cancer are usually cystic tumors with solid components of variable size.
  • Metastases from appendiceal tumor may present as ruptured mucinous ovarian tumors associated with pseudomyxoma peritonei.
  • Metastatic tumors from breast cancer are characterized by the relatively small size of the lesion.
  • Recognition of radiologic features of a variety of secondary ovarian tumors is beneficial for suspecting the secondary tumors under certain clinical conditions, and thus determining the appropriate management of the patients.
  • [MeSH-major] Magnetic Resonance Imaging / methods. Ovarian Neoplasms / diagnosis. Ovarian Neoplasms / secondary. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Diagnosis, Differential. Female. Humans

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  • (PMID = 17318680.001).
  • [ISSN] 1432-0509
  • [Journal-full-title] Abdominal imaging
  • [ISO-abbreviation] Abdom Imaging
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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64. Tran TA, Holloway RW, Finkler NJ: Metastatic appendiceal mucinous adenocarcinoma to well-differentiated diffuse mesothelioma of the peritoneal cavity: a mimicker of florid mesothelial hyperplasia in association with neoplasms. Int J Gynecol Pathol; 2008 Oct;27(4):526-30
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  • [Title] Metastatic appendiceal mucinous adenocarcinoma to well-differentiated diffuse mesothelioma of the peritoneal cavity: a mimicker of florid mesothelial hyperplasia in association with neoplasms.
  • Atypical/florid mesothelial hyperplasia associated with another neoplastic process is not an infrequent phenomenon and has been reported in a variety of tumors.
  • The subsequent operation, however, demonstrated a mucinous neoplasm of the appendix with involvement of the peritoneal cavity in the form of peritoneal mucinous carcinomatosis as well as metastases to the uterine serosa and adnexal surfaces.
  • Microscopic analysis revealed an appendiceal adenocarcinoma with signet-ring-cell features that has metastasized to a diffuse well-differentiated mesothelioma of the peritoneal cavity.
  • To the best of our knowledge, this is the first report of a metastatic appendiceal mucinous adenocarcinoma to a well-differentiated diffuse mesothelioma of the peritoneal cavity.
  • This unusual case report expands the spectrum of mesothelial proliferation in conjunction with a malignant neoplasm and serves to remind pathologists that such a concomitant occurrence exists.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Appendiceal Neoplasms / pathology. Mesothelioma / pathology. Peritoneal Neoplasms / secondary
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Histocytochemistry. Humans

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  • (PMID = 18753969.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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65. Yonemura Y, Tsukiyama G, Miyata R, Sako S, Endou Y, Hirano M, Mizumoto A, Matsuda T, Takao N, Ichinose M, Miura M, Hagiwara A, Li Y: Indication of peritonectomy for peritoneal dissemination. Gan To Kagaku Ryoho; 2010 Nov;37(12):2306-11
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  • Each of the 95, 58, 316, 31, 10 and 11 patients were from gastric, colorectal, appendiceal, ovarian, small bowel cancer and mesothelioma, respectively.
  • Peritonectomy was performed with a radical resection of the primary tumor and all gross PC with involved organs, peritoneum, or tissue that was deemed technically feasible and safe for the patient.
  • In appendiceal neoplasm, patients with PCI score less than 28 showed significantly better survival than those with PCI score greater than 29.
  • Among the various prognostic factors in appendiceal neoplasm and gastric cancer patients, CC-0 complete cytoreduction was the most important independent prognostic factor.
  • Peritonectomy is done to remove macroscopic disease and perioperative intraperitoneal chemotherapy to eradicate microscopic residual disease aiming to remove disease completely with a single procedure.
  • [MeSH-major] Carcinoma / surgery. Peritoneal Neoplasms / surgery. Peritoneum / surgery
  • [MeSH-minor] Aged. Appendiceal Neoplasms / drug therapy. Appendiceal Neoplasms / surgery. Colorectal Neoplasms / drug therapy. Colorectal Neoplasms / surgery. Combined Modality Therapy. Female. Humans. Intestinal Neoplasms / drug therapy. Intestinal Neoplasms / surgery. Male. Mesothelioma / drug therapy. Mesothelioma / surgery. Ovarian Neoplasms / drug therapy. Ovarian Neoplasms / surgery. Postoperative Complications. Stomach Neoplasms / drug therapy. Stomach Neoplasms / surgery. Treatment Outcome

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  • (PMID = 21224556.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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66. Simon R, Bourne PA, Yang Q, Spaulding BO, di Sant'Agnese PA, Wang HL, Xu H: Extrapulmonary small cell carcinomas express K homology domain containing protein overexpressed in cancer, but carcinoid tumors do not. Hum Pathol; 2007 Aug;38(8):1178-83
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  • [Title] Extrapulmonary small cell carcinomas express K homology domain containing protein overexpressed in cancer, but carcinoid tumors do not.
  • KOC acts to promote tumor cell proliferation by enhancing insulin-like growth factor-II protein expression.
  • This study aimed to examine KOC expression pattern in extrapulmonary neuroendocrine tumors.
  • Seventy-five extrapulmonary neuroendocrine tumors that were surgically resected or had undergone biopsy, including 53 small cell carcinomas (uterine cervix, 21; bladder, 10; colorectum, 13; prostate, 7; stomach, 1; and esophagus, 1) and 22 carcinoid tumors (colorectum, 10; appendix, 5; ileum, 4; duodenum, 2; and stomach, 1), were immunohistochemically studied using a monoclonal antibody against KOC.
  • Our results demonstrated that 47 small cell carcinomas (89%) showed moderate to strong positive staining for KOC, with 25 cases (53%) showing positivity in more than 90% of tumor cells and 22 cases (47%) in 40% to 80% of tumor cells.
  • Three cases showed weak staining in 5% to 10% of the tumor cells.
  • No KOC immunostaining was detected in 22 carcinoid tumors.
  • In addition, immunohistochemical detection of KOC expression may serve as a useful diagnostic tool in the distinction between small cell carcinoma and carcinoid tumor, particularly when the diagnostic material is a small biopsy with crushing artifact.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Carcinoid Tumor / metabolism. Carcinoma, Small Cell / metabolism. Neoplasm Proteins / metabolism. RNA-Binding Proteins / metabolism

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  • (PMID = 17521698.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / IMP3 protein, human; 0 / Neoplasm Proteins; 0 / RNA-Binding Proteins
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67. Stinner B, Rothmund M: Neuroendocrine tumours (carcinoids) of the appendix. Best Pract Res Clin Gastroenterol; 2005 Oct;19(5):729-38
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  • [Title] Neuroendocrine tumours (carcinoids) of the appendix.
  • Neuroendocrine tumours (NETs) of the appendix (formerly 'carcinoids') are rare and are usually detected incidentally after appendectomy.
  • They are preferentially located at the tip of the appendix.
  • Treatment for lesions 1-2 cm is controversial and needs further characterization of the tumour (i.e. mesoappendiceal invasion, vascular invasion, mitotic activity, proliferation markers) and careful patient risk evaluation.
  • Overall prognosis of small appendiceal NET is excellent in all ages.
  • [MeSH-major] Appendectomy / methods. Appendiceal Neoplasms / pathology. Appendiceal Neoplasms / surgery. Carcinoid Tumor / pathology. Carcinoid Tumor / surgery. Neoplasm Invasiveness / pathology
  • [MeSH-minor] Adult. Age Distribution. Aged. Biopsy, Needle. Female. Follow-Up Studies. Humans. Immunohistochemistry. Incidence. Male. Middle Aged. Neoplasm Staging. Risk Assessment. Treatment Outcome

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  • (PMID = 16253897.001).
  • [ISSN] 1521-6918
  • [Journal-full-title] Best practice & research. Clinical gastroenterology
  • [ISO-abbreviation] Best Pract Res Clin Gastroenterol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 32
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68. Li C, Kanthan R, Kanthan SC: Pseudomyxoma peritonei--a revisit: report of 2 cases and literature review. World J Surg Oncol; 2006;4:60
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  • BACKGROUND: Pseudomyxoma peritonei (PMP) is a rare, chronic, relapsing, diagnostically challenging and poorly understood disease characterized by disseminated mucinous ascites and peritoneal implants.
  • CASE PRESENTATION: We report two cases of PMP that represent the two biological variants of disseminated peritoneal adenomucinosis (DPAM)--the benign variant and the peritoneal mucinous carcinomatosis (PMCA)--the malignant variant, both of which were characterized by multiple relapses and progression of the disease despite aggressive management.
  • CONCLUSION: Even with a better understanding and recent advances in the management of these cases, PMP remains an enigmatic disease with a protracted clinical course characterized by multiple recurrences despite surgery and/or chemotherapy.
  • Recognition of PMP as a delayed consequence years later should alert all surgeons to be extremely vigilant when treating mucinous neoplasms of the appendix, with special care being directed towards adequate excision and thorough debridement at the initial diagnosis.

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  • (PMID = 16945158.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1574320
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69. Gelos M, Gelhaus J, Mehnert P, Bonhag G, Sand M, Philippou S, Mann B: Factors influencing lymph node harvest in colorectal surgery. Int J Colorectal Dis; 2008 Jan;23(1):53-9
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  • Early tumour stage (p<0.01), length of resected bowel segment (p<0.05) and right-sided location (p<0.001) had a significant influence on the number of resected LN.
  • Age, gender, surgeon volume, differentiation of the tumour, LN metastases, lymphatic invasion and depth of tumour invasion had no significant association with harvested LN number.
  • Furthermore, the presence or absence of the vermiform appendix and the length of the resected ileum segment in right-sided resections did not significantly affect the assessed LN.
  • [MeSH-major] Colectomy. Colorectal Neoplasms / surgery. Lymph Node Excision
  • [MeSH-minor] Aged. Female. Humans. Lymphatic Metastasis. Male. Neoplasm Invasiveness. Neoplasm Staging. Retrospective Studies. Treatment Outcome

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  • (PMID = 17823805.001).
  • [ISSN] 0179-1958
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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70. Yamaguchi H, Ishimaru M, Suzuki H, Yamashita H, Hatanaka K, Uekusa T, Nagawa H: Isolated abdominal wound recurrence after lymph-node dissection for appendiceal adenocarcinoma. Am J Surg; 2010 Jan;199(1):e7-9
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  • [Title] Isolated abdominal wound recurrence after lymph-node dissection for appendiceal adenocarcinoma.
  • Postoperative histology revealed a moderately differentiated adenocarcinoma in the appendix that invaded the submucosa along with lymphatic involvement.
  • Forty-three days later, an ileocecal resection with radical lymph node dissection was performed through a midline incision.
  • A complete excision of the tumor and the invaded portion of the ileum was performed.
  • [MeSH-major] Abdominal Wall / pathology. Adenocarcinoma / secondary. Adenocarcinoma / surgery. Appendiceal Neoplasms / surgery. Lymph Nodes / surgery. Neoplasm Recurrence, Local / pathology
  • [MeSH-minor] Abdominal Pain / diagnosis. Abdominal Pain / etiology. Appendectomy / methods. Cicatrix / pathology. Follow-Up Studies. Humans. Immunohistochemistry. Lymph Node Excision / methods. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. Reoperation. Risk Assessment. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 19837396.001).
  • [ISSN] 1879-1883
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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71. Young RH: From krukenberg to today: the ever present problems posed by metastatic tumors in the ovary: part I. Historical perspective, general principles, mucinous tumors including the krukenberg tumor. Adv Anat Pathol; 2006 Sep;13(5):205-27
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] From krukenberg to today: the ever present problems posed by metastatic tumors in the ovary: part I. Historical perspective, general principles, mucinous tumors including the krukenberg tumor.
  • This review considers historical aspects of metastatic tumors to the ovary, general principles that aid in their evaluation, and metastatic mucinous tumors, including the Krukenberg tumor.
  • The historical timeline on the Krukenberg tumor dates back to the legendary Sir James Paget and the story is followed through the well-known, albeit flawed, contribution of Friedrich Krukenberg and others who have contributed important papers over the years, including the overlooked contribution of the French investigator Gauthier-Villars.
  • Contributions on mucinous tumors conclude the historical perspective, note being made of the recent evidence suggesting that the long held contention of Dr Robert E.
  • Scully that ovarian mucinous tumors in patients with pseudomyxoma peritonei usually originate from the appendix is correct.
  • The section on general principles highlights the many clinical, gross, microscopic, and special techniques such as immunohistochemistry that may aid in determining that an ovarian tumor is metastatic with emphasis on the first 3 mentioned aspects.
  • Problematic features such as a tendency for metastatic tumors to be cystic, even when the primary tumors are not, and for many metastatic tumors to mature in the ovary (so-called maturation phenomenon), are emphasized.
  • The contribution on the Krukenberg tumor reviews the varied microscopy of this tumor pointing out that the well-known pattern of signet-ring cells in a cellular stroma, albeit characteristic, is often not striking and frequently overshadowed by other microscopic features.
  • The final portion of the essay reviews mucinous tumors of non-Krukenberg type, beginning with those that originate from the appendix.
  • The appendiceal neoplasms have distinctive features in most cases being particularly well differentiated, and this is also seen in their ovarian metastases.
  • Other mucinous tumors that commonly simulate closely metastatic neoplasms, include those from the pancreas in particular, but also diverse other sites, are then reviewed.
  • [MeSH-major] Krukenberg Tumor / secondary. Medical Oncology / history. Ovarian Neoplasms / secondary
  • [MeSH-minor] Adenocarcinoma, Mucinous / secondary. Appendiceal Neoplasms / pathology. Diagnosis, Differential. Female. History, 20th Century. Humans. Pancreatic Neoplasms / pathology. Periodicals as Topic / history

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  • (PMID = 16998315.001).
  • [ISSN] 1072-4109
  • [Journal-full-title] Advances in anatomic pathology
  • [ISO-abbreviation] Adv Anat Pathol
  • [Language] eng
  • [Publication-type] Historical Article; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 70
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72. O'Donnell ME, Carson J, Garstin WI: Surgical treatment of malignant carcinoid tumours of the appendix. Int J Clin Pract; 2007 Mar;61(3):431-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical treatment of malignant carcinoid tumours of the appendix.
  • Since their first description in 1882, malignant neoplasms of the appendix still remain rare.
  • Malignant carcinoid tumours are the most common accounting for 85% of all appendiceal neoplasms.
  • Preoperative diagnosis is invariably difficult, and precise treatment protocols for these neoplasms remain unclear.
  • Other appendiceal pathologies were identified following hemicolectomy and oophorectomy.
  • However, small CCTs less than 2 cm in diameter at the tip of the appendix, with a low proliferative index, without angiolymphatic or mesoappendiceal extension can be treated by appendicectomy.
  • Following oncological assessment, further adjuvant therapy should be considered for patients with advanced disease.
  • [MeSH-major] Appendectomy / methods. Appendiceal Neoplasms / surgery. Carcinoid Tumor / surgery. Colectomy / methods

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  • (PMID = 16911574.001).
  • [ISSN] 1368-5031
  • [Journal-full-title] International journal of clinical practice
  • [ISO-abbreviation] Int. J. Clin. Pract.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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73. Pal R, Datta A, Fornace AJ Jr, Bittner ML, Dougherty ER: Boolean relationships among genes responsive to ionizing radiation in the NCI 60 ACDS. Bioinformatics; 2005 Apr 15;21(8):1542-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • AVAILABILITY: The appendix is available at http://gsp.tamu.edu/Publications/supplement.htm CONTACT: edward@ee.tamu.edu.
  • [MeSH-major] Gene Expression Profiling / methods. Gene Expression Regulation, Neoplastic / radiation effects. Logistic Models. Models, Biological. Neoplasm Proteins / metabolism. Neoplasms / metabolism. Radiation, Ionizing. Signal Transduction / radiation effects
  • [MeSH-minor] Cell Line, Tumor / metabolism. Cell Line, Tumor / radiation effects. Computer Simulation. Humans. Multivariate Analysis

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  • (PMID = 15598836.001).
  • [ISSN] 1367-4803
  • [Journal-full-title] Bioinformatics (Oxford, England)
  • [ISO-abbreviation] Bioinformatics
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Neoplasm Proteins
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74. Szanto I, Rubbia-Brandt L, Kiss P, Steger K, Banfi B, Kovari E, Herrmann F, Hadengue A, Krause KH: Expression of NOX1, a superoxide-generating NADPH oxidase, in colon cancer and inflammatory bowel disease. J Pathol; 2005 Oct;207(2):164-76
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  • [Title] Expression of NOX1, a superoxide-generating NADPH oxidase, in colon cancer and inflammatory bowel disease.
  • In this study we characterized NOX1 expression in human colon samples derived from healthy control subjects and patients with colon cancer or inflammatory bowel disease (IBD).
  • In addition, a population of lymphocytes, particularly in the appendix, showed NOX1 expression.
  • Lymphocytes in lesions of Crohn's disease and ulcerative colitis were also strongly positive for NOX1.
  • [MeSH-major] Colonic Neoplasms / metabolism. Inflammatory Bowel Diseases / metabolism. NADPH Oxidase / analysis. Reactive Oxygen Species / metabolism
  • [MeSH-minor] Adenocarcinoma / metabolism. Adult. Aged. Aged, 80 and over. Animals. Colitis, Ulcerative / metabolism. Colon / metabolism. Crohn Disease / metabolism. Female. Humans. Ileum / metabolism. In Situ Hybridization / methods. Lymphocytes / metabolism. Male. Mice. Mice, Inbred BALB C. Middle Aged. Neoplasm Proteins / analysis. RNA, Messenger / analysis. RNA, Neoplasm / analysis. Rectal Neoplasms / metabolism. Rectum / metabolism

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  • [Copyright] Copyright (c) 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
  • (PMID = 16086438.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Neoplasm Proteins; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 0 / Reactive Oxygen Species; EC 1.6.3.- / NOX1 protein, human; EC 1.6.3.1 / NADPH Oxidase
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75. Kane JM 3rd: The "alphabet soup" of peritoneal dissemination from appendiceal neoplasms and other malignancies. Ann Surg Oncol; 2006 May;13(5):597-9
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  • [Title] The "alphabet soup" of peritoneal dissemination from appendiceal neoplasms and other malignancies.
  • [MeSH-major] Adenocarcinoma, Mucinous / secondary. Appendiceal Neoplasms / pathology. Peritoneal Neoplasms / secondary
  • [MeSH-minor] Combined Modality Therapy. Disease Progression. Humans. Hyperthermia, Induced. Prognosis

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  • [CommentOn] Ann Surg Oncol. 2006 May;13(5):624-34 [16538401.001]
  • [CommentOn] Ann Surg Oncol. 2006 May;13(5):635-44 [16523363.001]
  • (PMID = 16538404.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Comment; Editorial
  • [Publication-country] United States
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76. Dupre MP, Jadavji I, Matshes E, Urbanski SJ: Diverticular disease of the vermiform appendix: a diagnostic clue to underlying appendiceal neoplasm. Hum Pathol; 2008 Dec;39(12):1823-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diverticular disease of the vermiform appendix: a diagnostic clue to underlying appendiceal neoplasm.
  • Acquired diverticula of the vermiform appendix are rare and arise as a result of different pathogenetic mechanisms.
  • One of the etiologies includes proximally located, often unsuspected small neoplasms.
  • Although the association of appendiceal diverticulosis and neoplasia is known, it remains underemphasized in the teaching and practice of surgical pathology.
  • To investigate the frequency of appendiceal neoplasms with acquired diverticulosis, we conducted a retrospective analysis of all appendectomy specimens received in our institution for a 55-month period (January 2002-July 2006).
  • Eleven (48%) appendectomy specimens with diverticulosis also harbored an appendiceal neoplasm.
  • The association of appendiceal neoplasms with diverticulosis was statistically significant (P < .0001, 2-sided Fisher exact test).
  • Neoplastic processes included 5 well-differentiated neuroendocrine tumors (carcinoids), 3 mucinous adenomas, 1 tubular adenoma, and 2 adenocarcinomas.
  • We stress the need for meticulous gross assessment with histologic examination of the entire appendectomy specimen in cases of appendiceal diverticulosis.
  • Thorough examination is required to rule out an underlying neoplasm as a cause of diverticulosis.
  • As acquired diverticula represent a rare finding, examination of the entire appendix in this setting does not create a significant impact on the workload within the pathologic laboratory.
  • [MeSH-major] Adenocarcinoma / pathology. Appendiceal Neoplasms / pathology. Appendix / pathology. Carcinoid Tumor / pathology. Cystadenoma, Mucinous / pathology. Diverticulum / pathology

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  • (PMID = 18715614.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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77. Yang WL, Yan CQ, Wang FJ, Wang HL: [Diagnosis and surgical treatment of carcinoid tumors of the appendix in 64 patients]. Zhonghua Zhong Liu Za Zhi; 2008 Jul;30(7):538-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Diagnosis and surgical treatment of carcinoid tumors of the appendix in 64 patients].
  • OBJECTIVE: To summarize the experience in the diagnosis and surgical treatment of carcinoid tumors of the appendix.
  • METHODS: From 1972 to 2006, 64 patients with carcinoid tumors of the appendix received surgical treatment in our hospitals.
  • The operation modes were determined according to the doctor's judgments based on the age of the patients, the nature, size, location, infiltration depth and lymph node metastasis of the tumors.
  • CONCLUSION: Carcinoid tumor of the appendix is rare with a high rate of misdiagnosis before operation.
  • Surgical resection is the only effective treatment for this disease and proper operation mode is the key to achieve good survival.
  • [MeSH-major] Appendiceal Neoplasms / diagnosis. Appendiceal Neoplasms / surgery. Carcinoid Tumor / diagnosis. Carcinoid Tumor / surgery. Diagnostic Errors
  • [MeSH-minor] Adolescent. Adult. Aged. Appendectomy. Colectomy / methods. Female. Follow-Up Studies. Humans. Liver Neoplasms / secondary. Lymph Node Excision. Lymphatic Metastasis. Male. Middle Aged. Retrospective Studies. Survival Rate. Young Adult

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  • (PMID = 19062724.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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78. Murphy EM, Farquharson SM, Moran BJ: Management of an unexpected appendiceal neoplasm. Br J Surg; 2006 Jul;93(7):783-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Management of an unexpected appendiceal neoplasm.
  • BACKGROUND: Appendiceal neoplasms are rare and most present unexpectedly as acute appendicitis.
  • METHODS: A systematic literature review was performed to access relevant publications on the presentation, pathology and management of appendiceal tumours.
  • RESULTS: Appendiceal tumours account for 0.4 to 1 per cent of all gastrointestinal tract malignancies and are found in 0.7 to 1.7 per cent of appendicectomy specimens.
  • Most are cured by simple appendicectomy if the tumour is less than 2 cm in size and does not involve the resection margin or mesoappendix.
  • Epithelial tumours may present with, or in time develop, pseudomyxoma peritonei, the optimal management of which involves complete tumour resection and intraperitoneal chemotherapy, usually available only in specialized centres.
  • CONCLUSION: Suggested algorithms for the management of unexpected appendiceal tumours are provided.
  • Recommendations are made for follow-up of patients with a perforated appendiceal epithelial tumour.
  • [MeSH-major] Appendectomy / methods. Appendiceal Neoplasms / surgery
  • [MeSH-minor] Humans. Incidental Findings. Neoplasm Staging. Treatment Outcome

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  • [Copyright] Copyright 2006 British Journal of Surgery Society Ltd.
  • (PMID = 16775823.001).
  • [ISSN] 0007-1323
  • [Journal-full-title] The British journal of surgery
  • [ISO-abbreviation] Br J Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 94
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79. McGory ML, Maggard MA, Kang H, O'Connell JB, Ko CY: Malignancies of the appendix: beyond case series reports. Dis Colon Rectum; 2005 Dec;48(12):2264-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignancies of the appendix: beyond case series reports.
  • PURPOSE: A comprehensive analysis was performed for five histologic types of appendiceal tumors to compare incidence, clinicopathologic features, survival, and appropriateness of surgery.
  • The appropriateness of the operative procedure (i.e. , appendectomy vs. colectomy) was examined by tumor type and size.
  • RESULTS: Tumor incidence, patient demographics, survival outcomes, and appropriateness of surgery varied significantly among the different appendiceal tumor histologies.
  • The most common appendiceal tumors were mucinous.
  • Although current guidelines specify that a right hemicolectomy (rather than an appendectomy) be performed for all noncarcinoid tumors and carcinoid tumors >2 cm, we found that 30 percent of noncarcinoids underwent appendectomy.
  • CONCLUSIONS: This study provides a population-based analysis of epidemiology, tumor characteristics, survival, and quality of care for appendiceal carcinomas.
  • This characterization provides a novel description of the presentation and outcomes for malignancies of the appendix and highlights that a substantial number of patients with appendiceal tumors may not be receiving appropriate surgical resection.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Appendiceal Neoplasms / pathology. Carcinoid Tumor / pathology. Carcinoma, Signet Ring Cell / pathology

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  • (PMID = 16258711.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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80. Caiazzo P, Comentale A, Rampone B, Di Lascio P, Morlino A, Pastore M, Del Vecchio G, Tramutoli PR: [Giant appendiceal mucocele during laparotomy for acute abdomen. Report of a case and brief review]. G Chir; 2010 Nov-Dec;31(11-12):511-3
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  • [Title] [Giant appendiceal mucocele during laparotomy for acute abdomen. Report of a case and brief review].
  • The authors describe a case of giant appendiceal mucocele, secondary to a mucinous neoplasm of the appendix, diagnosed during laparotomy for acute abdomen.
  • By a review of the literature they stress the rarity of this lesion, the particular onset in their case as acute complication of appendiceal neoplasm with rupture of the intestinal wall, the difficulties of diagnosis and management in emergency.
  • [MeSH-major] Abdomen, Acute / surgery. Appendiceal Neoplasms / diagnosis. Appendix. Cystadenoma, Mucinous / diagnosis. Laparotomy. Mucocele / pathology. Mucocele / surgery
  • [MeSH-minor] Aged. Body Mass Index. Diagnosis, Differential. Female. Humans. Incidental Findings. Obesity / complications. Risk Factors. Treatment Outcome

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  • (PMID = 21232194.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Italy
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81. Terada T: Non-invasive Adenocarcinoma of the Vermiform Appendix: Incidence and Report of Four Cases among 512 Appendectomies. Gastroenterology Res; 2009 Aug;2(4):238-241
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Non-invasive Adenocarcinoma of the Vermiform Appendix: Incidence and Report of Four Cases among 512 Appendectomies.
  • : Tumors of the vermiform appendix are relatively rare.
  • More than 50% of appendiceal tumors are carcinoid tumors.
  • The author reviewed 512 consecutive pathological specimens of appendectomies in last ten years in our pathology laboratory in search for appendiceal tumors.
  • No other tumors including carcinoid tumors were recognized.
  • Pathologically, all the 4 tumors were non-invasive adenocarcinomas: 2 cases were flat type adenocarcinoma, 1 case was papillary adenocarcinoma, and 1 case was mucinous adenocarcinoma.
  • The results suggest that incidence of appendiceal adenocarcinoma was 0.8% of all appendectomies, and that non-invasive adenocarcinoma of the appendix shows variable morphologies, and that postoperative clinical outcome of non-invasive appendiceal tumor is good.

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  • (PMID = 27942282.001).
  • [ISSN] 1918-2805
  • [Journal-full-title] Gastroenterology research
  • [ISO-abbreviation] Gastroenterology Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Keywords] NOTNLM ; Adenocarcinoma / Appendix / Histopathology / Non-invasive carcinoma / appendicitis
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82. Sugarbaker PH: The natural history, gross pathology, and histopathology of appendiceal epithelial neoplasms. Eur J Surg Oncol; 2006 Aug;32(6):644-7
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  • [Title] The natural history, gross pathology, and histopathology of appendiceal epithelial neoplasms.
  • AIM: To report the pathology of appendiceal epithelial neoplasms a review of the Washington Cancer Institute experience and a PubMed literature search was performed.
  • FINDINGS: Epithelial appendiceal neoplasms present a significant oncologic challenge.
  • CONCLUSIONS: Appendiceal epithelial neoplasms should be regarded as a distinct clinical entity with special clinical treatments used for optimal management.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Adenoma / pathology. Appendiceal Neoplasms / pathology

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  • (PMID = 16621426.001).
  • [ISSN] 0748-7983
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 17
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83. Shinoda M, Hatano S, Kawakubo H, Kakefuda T, Omori T, Ishii S: Adult cecoanal intussusception caused by cecum cancer: report of a case. Surg Today; 2007;37(9):802-5
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  • The defect was moved back to oral side with the pressure of the enema, revealing a tumor originating in the cecum.
  • Laparotomy confirmed that the tumor originated at the bottom of the appendix in the cecum.
  • We performed partial resection of the cecum containing the tumor and appendix.
  • The pathological finding was submucosal adenocarcinoma in adenoma.
  • [MeSH-major] Anal Canal / pathology. Cecal Neoplasms / complications. Cecum / pathology. Intussusception / etiology

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  • (PMID = 17713738.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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84. de la Fuente-Lira M, Rocha-Guevara ER, Márquez-Rocha ML, Salazar-Lozano C, Jaramillo-Solís O, Ortiz-Maldonado AL: [Appendiceal mucocele and gangrenous cholecystitis]. Cir Cir; 2006 Jul-Aug;74(4):273-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Appendiceal mucocele and gangrenous cholecystitis].
  • OBJECTIVE: We present a case report of appendiceal mucocele and gangrenous cholecystitis.
  • SETTING: Hospital de Especialidades, Centro Médico Nacional Siglo XXI, México, D.F.
  • CLINICAL CASE: An 80-year-old man was admitted to the hospital with diagnosis of acute cholecystitis and abdominal tumor under study, with complaints of abdominal pain for 10 days located in the right upper quadrant, without fever or significant weight loss.
  • CT of the abdomen revealed thickening of the gallbladder wall and acute local inflammation, as well as the presence of abdominal tumor in the right lower quadrant.
  • The patient was surgically explored with the following findings: gangrenous cholecystitis and appendiceal tumor of 20 cm length.
  • The final histological report was appendiceal mucocele and the patient was discharged after 5 days.
  • [MeSH-major] Appendix. Cecal Diseases / complications. Cholecystitis / complications. Gallbladder / pathology. Mucocele / complications

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  • (PMID = 17022900.001).
  • [ISSN] 0009-7411
  • [Journal-full-title] Cirugía y cirujanos
  • [ISO-abbreviation] Cir Cir
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Mexico
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85. Lai HW, Loong CC, Tai LC, Wu CW, Lui WY: Incidence and odds ratio of appendicitis as first manifestation of colon cancer: a retrospective analysis of 1873 patients. J Gastroenterol Hepatol; 2006 Nov;21(11):1693-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND AND AIM: Obstruction of the lumen of the appendix is the major cause of appendicitis.
  • Tumors could obstruct this lumen and cause appendicitis in the elderly.
  • CONCLUSIONS: In patients over 40 years who present with symptoms of acute appendicitis the possibility of a coexistent colonic neoplasm should always be kept in mind.
  • [MeSH-major] Appendicitis / epidemiology. Colonic Neoplasms / epidemiology
  • [MeSH-minor] Acute Disease. Adult. Aged. Aged, 80 and over. Appendectomy. Chi-Square Distribution. Female. Humans. Incidence. Male. Middle Aged. Odds Ratio. Retrospective Studies. Taiwan / epidemiology

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  • (PMID = 16984591.001).
  • [ISSN] 0815-9319
  • [Journal-full-title] Journal of gastroenterology and hepatology
  • [ISO-abbreviation] J. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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86. Dilek S, Dilek U, Dede M, Deveci MS, Yenen MC: The role of omentectomy and appendectomy during the surgical staging of clinical stage I endometrial cancer. Int J Gynecol Cancer; 2006 Mar-Apr;16(2):795-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Grade, myometrial invasion, cervical and adnexal involvement and positive peritoneal cytology, lymph node and omentum and appendix involvement were recorded.
  • Two cases (3.9%) of metastasis to appendix were seen.
  • We conclude that omentectomy gives additional information about extrauterine spread of tumor without increased operational morbidity and should be performed as a component of surgical staging in the presence of normal appeared omentum.
  • [MeSH-major] Adenocarcinoma / pathology. Appendectomy. Endometrial Neoplasms / pathology. Omentum / surgery. Peritoneal Cavity / pathology
  • [MeSH-minor] Adult. Aged. Female. Humans. Lymph Nodes / pathology. Lymphatic Metastasis / pathology. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Retrospective Studies. Risk Factors

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  • (PMID = 16681763.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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87. Omohwo C, Nieroda CA, Studeman KD, Thieme H, Kostuik P, Ross AS, Holter DR, Gushchin V, Merriman B, Sardi A: Complete cytoreduction offers longterm survival in patients with peritoneal carcinomatosis from appendiceal tumors of unfavorable histology. J Am Coll Surg; 2009 Sep;209(3):308-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Complete cytoreduction offers longterm survival in patients with peritoneal carcinomatosis from appendiceal tumors of unfavorable histology.
  • BACKGROUND: Cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) is a rapidly evolving treatment for metastatic appendiceal neoplasms.
  • The aim of this study was to show the effect of complete cytoreduction (CC) on survival in patients undergoing CRS and HIPEC for high-grade appendiceal neoplasm.
  • STUDY DESIGN: A retrospective study of a prospective database of 56 patients (from 1999 to 2007) with appendiceal neoplasms treated with CRS and HIPEC was carried out.
  • Histology of the disease, CC score, and peritoneal cancer index (PCI) score were assessed independently and collectively for each group of patients.
  • Survival analysis by tumor histology was 80% for patients with low-grade tumors and 52% for patients with high-grade tumors (p = 0.024).
  • There was no statistically significant difference in survival between the low-grade and high-grade tumors when a complete cytoreduction was performed in both groups of patients: 80% versus 68% (p = 0.69).
  • CONCLUSIONS: CRS and HIPEC is an effective treatment for patients with disseminated appendiceal tumors.
  • High-grade tumors also benefit from this approach and should not be excluded from CRS and HIPEC.
  • Every effort should be made to achieve a complete cytoreduction regardless of the tumor histology.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Appendiceal Neoplasms / pathology. Hyperthermia, Induced. Peritoneal Neoplasms / drug therapy. Peritoneal Neoplasms / secondary. Peritoneal Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Chi-Square Distribution. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Neoplasm Staging. Proportional Hazards Models. Reoperation. Retrospective Studies. Survival Analysis. Treatment Outcome

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  • (PMID = 19717034.001).
  • [ISSN] 1879-1190
  • [Journal-full-title] Journal of the American College of Surgeons
  • [ISO-abbreviation] J. Am. Coll. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Biomarkers, Tumor
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88. Bijelic L, Yan TD, Sugarbaker PH: Treatment failure following complete cytoreductive surgery and perioperative intraperitoneal chemotherapy for peritoneal dissemination from colorectal or appendiceal mucinous neoplasms. J Surg Oncol; 2008 Sep 15;98(4):295-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Treatment failure following complete cytoreductive surgery and perioperative intraperitoneal chemotherapy for peritoneal dissemination from colorectal or appendiceal mucinous neoplasms.
  • BACKGROUND: Peritonectomy combined with perioperative intraperitoneal chemotherapy is a successful treatment option for patients with peritoneal dissemination of appendiceal and colorectal malignancy.
  • METHODS: Patients with peritoneal dissemination from appendiceal or colorectal malignancy who underwent complete cytoreduction and perioperative intraperitoneal chemotherapy were included in this study.
  • Data regarding recurrent disease found on abdominal exploration and/or diagnostic studies was extracted from a prospective database and analyzed.
  • RESULTS: Seventy patients with colorectal cancer carcinomatosis and 402 with appendiceal neoplasm were analyzed.
  • The median survival of 49 patients with colorectal cancer was 33 months while the median survival for patients with appendiceal neoplasms was not reached.
  • The most common type of recurrent disease was a localized intra-abdominal recurrence for both appendiceal and colon cancer patients.
  • Patients who underwent second surgery for recurrent disease had an improved survival.
  • This resulted in 5-year survival in 17% of colorectal patients and 70% of the appendiceal mucinous neoplasm patients.
  • [MeSH-major] Adenocarcinoma, Mucinous / therapy. Appendiceal Neoplasms / pathology. Chemotherapy, Cancer, Regional Perfusion / methods. Colorectal Neoplasms / pathology. Hyperthermia, Induced. Peritoneal Neoplasms / therapy

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  • (PMID = 18726900.001).
  • [ISSN] 1096-9098
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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89. Khan AA, Tambiah J, Cane P, Lang-Lazdunski L: Prolonged survival in a patient with recurrent pulmonary metastases secondary to mucinous cystadenocarcinoma of the appendix with pseudomyxomatous peritonei. Ann Thorac Surg; 2007 May;83(5):1893-4
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  • [Title] Prolonged survival in a patient with recurrent pulmonary metastases secondary to mucinous cystadenocarcinoma of the appendix with pseudomyxomatous peritonei.
  • He underwent bilateral staged metastatectomies for metastases 7 years after the diagnosis and further metastasectomy after a recent recurrence.
  • [MeSH-major] Appendiceal Neoplasms / surgery. Cystadenocarcinoma, Mucinous / surgery. Lung Neoplasms / surgery. Neoplasm Recurrence, Local / surgery

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  • (PMID = 17462430.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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90. Ramirez PT, Slomovitz BM, McQuinn L, Levenback C, Coleman RL: Role of appendectomy at the time of primary surgery in patients with early-stage ovarian cancer. Gynecol Oncol; 2006 Dec;103(3):888-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Anderson Cancer Center between January 1992 and December 2004 and who did not meet any of the following exclusion criteria: stage III or IV ovarian cancer, appendectomy as part of a second-look procedure or secondary tumor-reductive surgery, primary appendiceal cancer, primary gastrointestinal malignancy with metastasis to the appendix, incomplete clinicopathologic data, appendicitis as a preoperative diagnosis, primary fallopian tube cancer, primary peritoneal cancer, or documented dual primary tumors.
  • Histologic diagnoses were as follows: invasive epithelial carcinoma, 35 patients (61%); tumor of low malignant potential, 15 patients (26%); malignant germ cell tumor, 4 patients (7%); and other, 3 patients (5%).
  • Twenty-three patients (40%) had pure mucinous tumors.
  • Forty-six patients (81%) had stage I and 11 patients (19%) had stage II disease.
  • No patient had evidence of appendiceal involvement.
  • [MeSH-major] Appendectomy / utilization. Appendix / surgery. Ovarian Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Cystadenocarcinoma, Mucinous / epidemiology. Cystadenocarcinoma, Mucinous / pathology. Cystadenocarcinoma, Mucinous / surgery. Female. Humans. Medical Records. Middle Aged. Neoplasm Staging. Neoplasms, Germ Cell and Embryonal / epidemiology. Neoplasms, Germ Cell and Embryonal / pathology. Neoplasms, Germ Cell and Embryonal / surgery. Neoplasms, Glandular and Epithelial / epidemiology. Neoplasms, Glandular and Epithelial / pathology. Neoplasms, Glandular and Epithelial / surgery. Ovariectomy / utilization. Postoperative Complications. Retrospective Studies. Texas / epidemiology

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  • (PMID = 16806436.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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91. Moran BJ, Mukherjee A, Sexton R: Operability and early outcome in 100 consecutive laparotomies for peritoneal malignancy. Br J Surg; 2006 Jan;93(1):100-4
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  • BACKGROUND: Peritoneal malignancy is common at the terminal stages of many intra-abdominal neoplasms.
  • In selected patients a novel approach of complete macroscopic tumour removal by extensive surgical cytoreduction, combined with intraperitoneal chemotherapy, provides a possibility of cure.
  • One hundred underwent laparotomy, of whom 85 had a primary appendiceal tumour.
  • Treatment aims were complete macroscopic tumour excision combined with intraoperative intraperitoneal chemotherapy.
  • RESULTS: Sixty-five patients had complete macroscopic tumour excision, 28 palliative major cytoreduction and seven were inoperable.
  • At a median follow-up of 30 (range 3-113) months, 44 of 51 patients with primary appendiceal tumours who had complete macroscopic cytoreduction were alive and 36 were disease free.
  • [MeSH-major] Laparotomy / methods. Peritoneal Neoplasms / surgery

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  • [Copyright] Copyright 2005 British Journal of Surgery Society Ltd.
  • (PMID = 16302177.001).
  • [ISSN] 0007-1323
  • [Journal-full-title] The British journal of surgery
  • [ISO-abbreviation] Br J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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92. Pigolkin IuI, Dolzhanskiĭ OV, Kostin AIu: [Appendicular metastatic involvement in breast cancer]. Arkh Patol; 2008 May-Jun;70(3):46-8
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  • The 60-year-old female patient developed the signs of acute appendicitis 18 years after detection of primary tumor; after appendectomy the intraoperative appendular specimens exhibited trains of tumor cells that infiltrated the mid- and lower muscle layer third.
  • Immunohistochemical study revealed a moderate expression of Er and Pgr receptors (150 H scores), a positive reaction with EMA, K7, K6, and lactoalbumin The authors review the data available in the literature on the specific features of metastatic spread into the appendix and on management tactics in these patients.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Appendiceal Neoplasms / secondary. Breast Neoplasms / pathology
  • [MeSH-minor] Appendicitis / metabolism. Appendicitis / pathology. Female. Humans. Immunohistochemistry. Middle Aged. Neoplasm Metastasis. Neoplasm Proteins / metabolism. Time Factors


93. Yantiss RK, Shia J, Klimstra DS, Hahn HP, Odze RD, Misdraji J: Prognostic significance of localized extra-appendiceal mucin deposition in appendiceal mucinous neoplasms. Am J Surg Pathol; 2009 Feb;33(2):248-55
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prognostic significance of localized extra-appendiceal mucin deposition in appendiceal mucinous neoplasms.
  • Appendiceal mucinous neoplasms confined to the mucosa are benign, whereas those with disseminated peritoneal mucin deposits often follow an indolent, but malignant, course.
  • Not infrequently, appendiceal mucinous neoplasms are associated with localized periappendiceal mucin deposits, but lack diffuse peritoneal involvement.
  • Although some investigators consider both acellular and cellular periappendiceal mucin to pose no, or minimal, risk for recurrent disease, the biologic importance of localized extra-appendiceal mucin has never been evaluated.
  • We identified 65 patients with appendiceal mucinous neoplasms, all of whom had localized periappendiceal mucin deposits without diffuse peritoneal involvement, and assessed them for the presence of extra-appendiceal epithelium and clinical outcome.
  • Most (77%) cases showed acellular periappendiceal mucin, but 15 (23%) had scant extra-appendiceal epithelium (range: 1 to 12 cell clusters).
  • Upon follow-up (mean: 48 mo), 2 (4%) patients with acellular periappendiceal mucin developed diffuse peritoneal disease, but neither of these appendices was submitted in total for histologic evaluation.
  • In contrast, 5 of 15 (33%) patients with cellular periappendiceal mucin developed mucinous ascites, including 1 who eventually died of disease (P=0.03).
  • Thus, patients with appendiceal mucinous neoplasms and acellular periappendiceal mucin are unlikely to develop recurrent disease.
  • However, microscopic examination of the entire appendix is necessary, as lesions with extra-appendiceal tumor cells are more likely to progress to disseminated disease and result in death of the patient, even if the mucin is paucicellular and confined to the periappendiceal region.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Appendiceal Neoplasms / pathology. Mucins / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Child. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / pathology. Prognosis

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  • (PMID = 18852679.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Mucins
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94. Shapiro JF, Chase JL, Wolff RA, Lambert LA, Mansfield PF, Overman MJ, Ohinata A, Liu J, Wang X, Eng C: Modern systemic chemotherapy in surgically unresectable neoplasms of appendiceal origin: a single-institution experience. Cancer; 2010 Jan 15;116(2):316-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Modern systemic chemotherapy in surgically unresectable neoplasms of appendiceal origin: a single-institution experience.
  • BACKGROUND: Appendiceal neoplasms include tumors ranging from benign-appearing cells with widespread mucin deposits to aggressive poorly differentiated signet ring cell adenocarcinomas.
  • Traditionally, these tumors are treated with cytoreductive surgery followed by hyperthermic intraperitoneal chemotherapy.
  • A retrospective analysis was conducted to determine the benefit of modern systemic chemotherapy in patients with disseminated appendiceal neoplasm who were not considered optimal candidates for cytoreductive surgery.
  • Anderson Cancer Center tumor registry between January 2000 and July 2005.
  • RESULTS: Of 186 patients diagnosed with appendiceal neoplasm, 54 (29%) patients considered to be suboptimal surgical candidates received > or =2 cycles of systemic chemotherapy.
  • Thirty (55.6%) patients had a disease control rate noted as a complete response, partial response, or stable disease.
  • CONCLUSIONS: Systemic chemotherapy has a role in appendiceal neoplasm patients who are suboptimal candidates for cytoreductive surgery.
  • The intermediate PFS indicates the challenges that exist for appendiceal neoplasm patients in this setting.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Appendiceal Neoplasms / drug therapy
  • [MeSH-minor] Adult. Aged. Disease-Free Survival. Female. Humans. Hyperthermia, Induced. Injections, Intraperitoneal. Male. Middle Aged. Retrospective Studies. Survival Analysis

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  • (PMID = 19904805.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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95. Gupta S, Parsa V, Adsay V, Heilbrun LK, Smith D, Shields AF, Weaver D, Philip PA, El-Rayes BF: Clinicopathological analysis of primary epithelial appendiceal neoplasms. Med Oncol; 2010 Dec;27(4):1073-8
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  • [Title] Clinicopathological analysis of primary epithelial appendiceal neoplasms.
  • Appendiceal carcinomas are classified into three distinct histopathological disease entities: disseminated peritoneal adenomucinosis (DPAM), peritoneal mucinous carcinomatosis (PMCA), or peritoneal mucinous carcinomatosis with intermediate or discorant features (PMCA I/D).
  • The treatment of appendiceal tumors should be based on accurate histopathological classification, per previously reported case series.
  • The objective of this study was to evaluate the clinicopathologic presentation and outcome of patients with appendiceal tumors treated at our institution over a 15-year period.
  • We identified patients with appendiceal tumors diagnosed or treated at our institution from January 1989 through May 2004.
  • Chart review for age, gender, signs and symptoms at diagnosis, and treatment was performed.
  • Review of the pathologic specimens was performed and tumors were classified as DPAM, PMCA I/D, or PMCA.
  • Three distinct histopathological disease entities exist in appendiceal tumors.
  • The prognosis and management of these tumors should be based on the extent of disease and pathologic diagnosis.

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  • [Cites] Ann Surg Oncol. 2005 Jan;12(1):72-80 [15827781.001]
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  • (PMID = 19851895.001).
  • [ISSN] 1559-131X
  • [Journal-full-title] Medical oncology (Northwood, London, England)
  • [ISO-abbreviation] Med. Oncol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P30 CA022453; United States / NCI NIH HHS / CA / CA-22453
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS513798; NLM/ PMC3883058
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96. Palanivelu C, Rangarajan M, Annapoorni S, Senthilkumar R, Anand NV: Laparoscopic right hemicolectomy for goblet-cell carcinoid of the appendix: report of a rare case and literature survey. J Laparoendosc Adv Surg Tech A; 2008 Jun;18(3):417-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Laparoscopic right hemicolectomy for goblet-cell carcinoid of the appendix: report of a rare case and literature survey.
  • Tumors of the appendix are rare entities, and the majority of them are discovered accidentally during an investigation for other conditions.
  • Laparoscopic surgery for appendiceal goblet-cell carcinoid (GCC) has only been reported once before.
  • Our patient was incidentally discovered to have an appendiceal tumor and was referred to us for laparoscopy.
  • The tumor involved the body of the appendix and was adherent to the cecum.
  • Histopathology confirmed an appendiceal goblet-cell carcinoid.
  • GCC is a rare tumor of the appendix.
  • Hemicolectomy is indicated in specific situations, such as local involvement or tumor size >2 cm.
  • In our patient, the tumor was adherent to the cecum and tumor size was 5 cm.
  • Laparoscopic surgery for appendiceal tumors is safe, feasible, and even may be beneficial.
  • [MeSH-major] Carcinoid Tumor / surgery. Colectomy
  • [MeSH-minor] Aged. Appendiceal Neoplasms / pathology. Appendiceal Neoplasms / surgery. Humans. Laparoscopy. Male

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  • (PMID = 18503377.001).
  • [ISSN] 1092-6429
  • [Journal-full-title] Journal of laparoendoscopic & advanced surgical techniques. Part A
  • [ISO-abbreviation] J Laparoendosc Adv Surg Tech A
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 18
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97. Bittle MM, Chew FS: Radiological reasoning: recurrent right lower quadrant inflammatory mass. AJR Am J Roentgenol; 2005 Sep;185(3 Suppl):S188-94
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  • CT showed a right lower quadrant inflammatory mass presumed to be an appendiceal abscess.
  • The final pathologic diagnosis was mucinous cystadenoma with perforation.
  • CONCLUSION: Primary neoplasms of the appendix are uncommon but should be considered in the correct clinical and imaging scenario.
  • [MeSH-major] Abscess / radiography. Appendiceal Neoplasms / radiography. Appendicitis / radiography. Cystadenoma, Mucinous / radiography

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  • (PMID = 16120902.001).
  • [ISSN] 0361-803X
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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98. Hayama T, Matsuda K, Shibuya H, Akahane T, Horiuchi A, Shimada R, Aoyagi Y, Nakamura K, Yamada H, Ishihara S, Nozawa K, Watanabe T: A case of appendiceal Crohn's disease in which a laparoscopic appendectomy was performed. Int Surg; 2010 Oct-Dec;95(4):338-42
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  • [Title] A case of appendiceal Crohn's disease in which a laparoscopic appendectomy was performed.
  • She underwent a barium enema examination during a medical checkup, which revealed a wall irregularity around the appendix, but the appendix itself was not visualized.
  • The patient was referred to our hospital for possible appendiceal neoplasm.
  • Colonoscopy revealed a tumor-like protrusion with marked redness at the entrance to the appendix.
  • Differential diagnosis of appendiceal Crohn's disease or appendiceal neoplasm was made, and laparoscopic appendectomy was performed.
  • Pathologic examination revealed inflammation in all layers of the appendiceal wall and noncaseating epithelioid cell granuloma, and a diagnosis of appendiceal Crohn's disease was made.
  • [MeSH-major] Appendectomy / methods. Appendicitis / surgery. Crohn Disease / surgery. Laparoscopy
  • [MeSH-minor] Aged. Biopsy. Colonoscopy. Diagnosis, Differential. Female. Humans. Positron-Emission Tomography. Tomography, X-Ray Computed


99. Chatelain D, Brevet M, Fuks D, Yzet T, Verhaeghe P, Regimbeau JM, Lauwers G, Sevestre H: [Inflammatory fibroid polyp, a rare tumor of the appendix]. Gastroenterol Clin Biol; 2008 Mar;32(3):274-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Inflammatory fibroid polyp, a rare tumor of the appendix].
  • [Transliterated title] Le polype fibroïde inflammatoire, une tumeur rare de l'appendice.
  • We report the rare occurrence of an inflammatory fibroid polyp of the appendix.
  • CT-scan showed an 8 cm appendiceal mass and a laparoscopic appendectomy was consequently performed.
  • On microscopic examination, the tumor consisted of spindle cells dispersed in a loose fibromyxoid stroma containing numerous blood cells and inflammatory cells with abundant eosinophils.
  • On immunohistochemistry, the spindle tumor cells were positive for vimentin, fascin and focally for CD34 and CD35.
  • Inflammatory fibroid polyp is a rare benign mesenchymal tumor of the gastrointestinal tract rarely reported in the appendix.
  • This tumor shares some common pathologic features with the myofibroblatic inflammatory tumor but they are two different entities.
  • The pathogenesis of this tumor remains unclear but fascin and CD35 immunoreactivity of the tumor cells suggests a probable dendritic cell origin.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Intestinal Polyps / pathology. Leiomyoma / pathology

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  • (PMID = 18353580.001).
  • [ISSN] 0399-8320
  • [Journal-full-title] Gastroentérologie clinique et biologique
  • [ISO-abbreviation] Gastroenterol. Clin. Biol.
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / CR1 protein, human; 0 / Carrier Proteins; 0 / Microfilament Proteins; 0 / Receptors, Complement 3b; 0 / Vimentin; 146808-54-0 / fascin
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100. Azordegan N, Yazdankhah A, Moghadasian MH: A rare case of coexistence of carcinoid tumor of appendix vermicularis and ileal endometriosis. Arch Gynecol Obstet; 2009 Feb;279(2):183-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A rare case of coexistence of carcinoid tumor of appendix vermicularis and ileal endometriosis.
  • BACKGROUND: Carcinoid tumor is the most common tumor of appendix with overall good prognosis.
  • CASE REPORT: We here report the coexistence of carcinoid tumor of appendix and ileal endometriosis in a 37-year-old nulliparous woman who came to the emergency room with right lower abdominal pain mimicking acute appendicitis.
  • With preoperative suspicion of acute appendicitis, laparatomy was performed and revealed apparently normal looking appendix, along with a nodule in the terminal ileum.
  • Both the appendix and ileal nodule were removed.
  • Histological examinations revealed carcinoid tumor of appendix and ileal endometriosis.
  • CONCLUSION: Many cases of carcinoid tumor of the appendix and ileal endometriosis are diagnosed incidentally.
  • [MeSH-major] Appendiceal Neoplasms / complications. Carcinoid Tumor / complications. Endometriosis / complications. Ileal Diseases / complications
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Prognosis






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