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1. Wittekind C: [TNM 2010. What's new?]. Pathologe; 2010 Oct;31 Suppl 2:153-60
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  • In the seventh edition of the TNM Classification of Malignant Tumours there are several entirely new classifications: upper aerodigestive mucosal melanoma, gastrointestinal stromal tumour, gastrointestinal carcinoid (neuroendocrine tumour), intrahepatic cholangiocarcinoma, Merkel cell carcinoma, uterine sarcomas, and adrenal cortical carcinoma.
  • Significant modifications concern carcinomas of the oesophagus, oesophagogastric junction, stomach, appendix, biliary tract, lung, skin, prostate and ophthalmic tumours, which will be not addressed in this article.
  • [MeSH-minor] Adrenal Cortex Neoplasms / classification. Adrenal Cortex Neoplasms / pathology. Bile Duct Neoplasms / classification. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic. Carcinoid Tumor / classification. Carcinoid Tumor / pathology. Carcinoma, Merkel Cell / classification. Carcinoma, Merkel Cell / pathology. Cholangiocarcinoma / classification. Cholangiocarcinoma / pathology. Digestive System Neoplasms / classification. Digestive System Neoplasms / pathology. Female. Gastrointestinal Stromal Tumors / classification. Gastrointestinal Stromal Tumors / pathology. Humans. Respiratory Tract Neoplasms / classification. Respiratory Tract Neoplasms / pathology. Sarcoma / classification. Sarcoma / pathology. Skin Neoplasms / classification. Skin Neoplasms / pathology. Uterine Neoplasms / classification. Uterine Neoplasms / pathology

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  • [Cites] Virchows Arch. 2006 Oct;449(4):395-401 [16967267.001]
  • [Cites] Ann Surg. 2010 Jan;251(1):46-50 [20032718.001]
  • [Cites] Cancer. 2010 Aug 15;116(16):3763-73 [20564099.001]
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  • [Cites] Virchows Arch. 2007 Oct;451(4):757-62 [17674042.001]
  • [Cites] J Clin Endocrinol Metab. 2010 Nov;95(11):4925-32 [20668036.001]
  • [Cites] Cancer. 2005 Feb 1;103(3):647-9 [15612025.001]
  • [Cites] Cancer. 2005 Jun 15;103(12):2507-16 [15856474.001]
  • (PMID = 20737151.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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2. Van Patten K, Parkash V, Jain D: Cadherin expression in gastrointestinal tract endometriosis: possible role in deep tissue invasion and development of malignancy. Mod Pathol; 2010 Jan;23(1):38-44
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  • The goal of this study was to evaluate the expression of N-cadherin, E-cadherin, and beta-catenin in peritoneal endometriotic implants, gastrointestinal endometriosis, and carcinoma arising in gastrointestinal endometriosis.
  • Cases of peritoneal endometriosis, gastrointestinal endometriosis, and carcinoma arising in gastrointestinal endometriosis were identified from our pathology database.
  • A total of 38 cases (peritoneal endometriosis (n=14), gastrointestinal endometriosis (n=21: 11 colon, 8 appendix, 2 small bowel), and 3 cases of endometrioid carcinoma arising in colonic endometriosis (n=3)) were included in the study.
  • All three cases of carcinoma arising in colonic endometriosis showed a total loss of N-cadherin in the tumor, but preserved E-cadherin and beta-catenin expression.


3. Vang R, Gown AM, Farinola M, Barry TS, Wheeler DT, Yemelyanova A, Seidman JD, Judson K, Ronnett BM: p16 expression in primary ovarian mucinous and endometrioid tumors and metastatic adenocarcinomas in the ovary: utility for identification of metastatic HPV-related endocervical adenocarcinomas. Am J Surg Pathol; 2007 May;31(5):653-63
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  • Most endocervical adenocarcinomas exhibit mucinous and/or endometrioid differentiation; they infrequently metastasize to the ovaries but may simulate primary ovarian tumors [both atypical proliferative (borderline) and carcinoma].
  • Immunohistochemical expression of p16 was assessed in 195 tumors, including 98 primary ovarian tumors (51 mucinous, 47 endometrioid, and 4 mixed mucinous-endometrioid tumors), 93 metastatic adenocarcinomas of known primary sites (colorectum: 34, endocervix: 19, pancreaticobiliary tract: 17, appendix: 7, stomach: 5), 11 metastatic adenocarcinomas of unknown origin (7 established as noncervical), and 4 adenocarcinomas of uncertain (primary ovarian vs. metastatic) origin.
  • Diffuse (>75% positive tumor cells) moderate to strong p16 expression is a sensitive (100%) and specific (97%) marker for identifying HPV-related endocervical adenocarcinomas metastatic to the ovary among the primary ovarian tumors and metastatic adenocarcinomas from other sites that are in the differential diagnosis of ovarian tumors having mucinous and/or endometrioid/endometrioidlike differentiation. p16 is useful as part of a panel of immunohistochemical markers for distinguishing primary ovarian tumors from metastases and, when diffusely positive, can suggest the cervix as a potential primary site for metastatic adenocarcinomas of unknown origin.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenocarcinoma, Mucinous / metabolism. Carcinoma, Endometrioid / metabolism. Cyclin-Dependent Kinase Inhibitor p16 / metabolism. Ovarian Neoplasms / metabolism. Uterine Cervical Neoplasms / metabolism
  • [MeSH-minor] Biomarkers, Tumor / metabolism. DNA, Viral / analysis. Diagnosis, Differential. Female. Humans. Immunoenzyme Techniques. In Situ Hybridization. Papillomaviridae / genetics. Papillomavirus Infections. Polymerase Chain Reaction


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4. Yong Jiang, Huawei Liu, Hu Long, Yingying Yang, Dianying Liao, Xiuhui Zhang: Goblet cell carcinoid of the appendix: a clinicopathological and immunohistochemical study of 26 cases from southwest china. Int J Surg Pathol; 2010 Dec;18(6):488-92
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  • [Title] Goblet cell carcinoid of the appendix: a clinicopathological and immunohistochemical study of 26 cases from southwest china.
  • Goblet cell carcinoid (GCC) of the appendix is characterized by a dual differentiation of both endocrine and gland.
  • The authors characterize GCC as a special low-grade malignant carcinoma with a primary epithelial differentiation and little neuroendocrine differentiation.

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  • (PMID = 20732910.001).
  • [ISSN] 1940-2465
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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5. van Eeden S, Offerhaus GJ, Hart AA, Boerrigter L, Nederlof PM, Porter E, van Velthuysen ML: Goblet cell carcinoid of the appendix: a specific type of carcinoma. Histopathology; 2007 Dec;51(6):763-73
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  • [Title] Goblet cell carcinoid of the appendix: a specific type of carcinoma.
  • AIMS: Goblet cell carcinoid is a poorly understood tumour of the appendix.
  • The formerly used term 'crypt cell carcinoma' may be more appropriate because it reflects the more aggressive clinical behaviour of these tumours as well as their greater similarity to adenocarcinomas rather than to carcinoids.

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  • [CommentIn] Histopathology. 2008 May;52(6):770-1 [18439158.001]
  • (PMID = 18042066.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Grant] United States / NIMHD NIH HHS / MD / 1P20 MD001824
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / KRAS protein, human; 0 / Proto-Oncogene Proteins; EC 3.6.5.2 / ras Proteins
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6. Kunz J, Makek M: [Primary adenocarcinoma of the appendix as differential diagnosis of advanced ovarian carcinoma]. Praxis (Bern 1994); 2006 Aug 16;95(33):1217-25
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  • [Title] [Primary adenocarcinoma of the appendix as differential diagnosis of advanced ovarian carcinoma].
  • [Transliterated title] Das primäre Adenokarzinom der Appendix als Differentialdiagnose des fortgeschrittenen Ovarialkarzinoms.
  • Malignant tumours of the appendix are rare.
  • Metastatic mucinous adenocarcinomas of the appendix are only reported as case histories.
  • Advanced primary adenocarcinomas of the appendix with ovarian metastases cannot be distinguished intraoperatively from a FIGO III ovarian carcinoma.
  • The pathologist makes the definitive diagnosis.
  • Surgical therapy of the isolated primary appendiceal carcinoma consists of a hemicolectomy--an appendectomy in favourable cases--and, in the case of a metastasised carcinoma, according to the guidelines for an advanced ovarian or colon carcinoma.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Adenocarcinoma, Mucinous / secondary. Appendiceal Neoplasms / diagnosis. Carcinoma, Signet Ring Cell / diagnosis. Carcinoma, Signet Ring Cell / secondary. Ovarian Neoplasms / diagnosis. Ovarian Neoplasms / secondary
  • [MeSH-minor] Appendix / pathology. Appendix / surgery. Diagnosis, Differential. Female. Humans. Hysterectomy, Vaginal. Middle Aged. Omentum / pathology. Omentum / surgery. Ovary / pathology. Ovary / surgery. Peritoneal Neoplasms / diagnosis. Peritoneal Neoplasms / pathology. Peritoneal Neoplasms / secondary. Peritoneal Neoplasms / surgery. Peritoneum / pathology. Peritoneum / surgery. Postoperative Complications / diagnosis. Postoperative Complications / pathology. Postoperative Complications / surgery. Reoperation

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  • (PMID = 16939122.001).
  • [ISSN] 1661-8157
  • [Journal-full-title] Praxis
  • [ISO-abbreviation] Praxis (Bern 1994)
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Switzerland
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7. Varga S, Konczili V, Zemanek P, Francz M, Nábrádi Z: [Metastasis of breast cancer presenting in the appendix]. Magy Seb; 2005 Oct;58(5):334-6
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  • [Title] [Metastasis of breast cancer presenting in the appendix].
  • [Transliterated title] Meglepetést okozó appendix avagy primer emlorák metasztázisa okozta appendicitis.
  • The pathology report of the appendix suggested the possibility of a metastasis of ductal breast carcinoma in the perforated appendix.
  • Probably the inflammation was caused by the infiltration of the appendix wall leading to perforation.
  • Immunohistochemical examination definitely proved that the metastasis in the appendix originated from the breast tumour.
  • [MeSH-major] Appendiceal Neoplasms. Appendicitis. Breast Neoplasms. Carcinoma, Ductal, Breast
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Immunohistochemistry. Middle Aged

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  • (PMID = 16496779.001).
  • [ISSN] 0025-0295
  • [Journal-full-title] Magyar sebészet
  • [ISO-abbreviation] Magy Seb
  • [Language] hun
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Hungary
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8. Hatami M, Whitney K, Goldberg GL: Primary bilateral ovarian and uterine Burkitt's lymphoma following chemotherapy for breast cancer. Arch Gynecol Obstet; 2010 Apr;281(4):697-702
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  • [Title] Primary bilateral ovarian and uterine Burkitt's lymphoma following chemotherapy for breast cancer.
  • A case of Burkitt's lymphoma involving the uterus, cervix, ovaries and appendix 15 years after adjuvant chemotherapy for breast cancer is presented.
  • Her past medical history was significant for an infiltrating ductal carcinoma of the left breast with positive lymph nodes and extra nodal invasion diagnosed at age 43.
  • Histologic sections of the uterus, cervix, ovaries, appendix and external iliac lymph node obtained at laparotomy revealed diffuse neoplastic lymphoid infiltration with necrosis.
  • After complete staging, chemotherapy was started and the patient is presently tumor free 41 months after the diagnosis.
  • Early diagnosis, aggressive chemotherapy, +/-surgical intervention, plays an important role in management and survival of patients with Burkitt's lymphoma.
  • [MeSH-major] Appendix / pathology. Breast Neoplasms / drug therapy. Burkitt Lymphoma / pathology. Carcinoma, Ductal, Breast / drug therapy. Neoplasms, Second Primary / pathology. Ovary / pathology. Uterus / pathology


9. Skrovina M, Czudek S, Bartos J, Ferák I, Adamcík L, Bezunková E, Vanko R: [The Peutz-Jeghers syndrome--a case review]. Rozhl Chir; 2007 Jan;86(1):24-6
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  • INTRODUCTION: The authors present a case review of a localized Peutz-Jeghers syndrome of the caecum, emulating a carcinoma.
  • METHODS: The patient who presented with insignificant family history with a diagnosed stenosing tumor of his appendix and histological findings of highly suspected adenocarcinoma, was indicated for surgical revision and right-sided hemicolectomy.
  • [MeSH-major] Diagnostic Errors. Hamartoma / diagnosis. Intestinal Polyps / diagnosis. Peutz-Jeghers Syndrome / diagnosis
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / surgery. Adult. Appendiceal Neoplasms / diagnosis. Appendiceal Neoplasms / surgery. Humans. Male

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  • (PMID = 17416075.001).
  • [ISSN] 0035-9351
  • [Journal-full-title] Rozhledy v chirurgii : měsíčník Československé chirurgické společnosti
  • [ISO-abbreviation] Rozhl Chir
  • [Language] cze
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Czech Republic
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10. Innis M, Sandiford N, Shenoy RK, Prussia PR, Zbar A: Carcinoma of the jejunum with multideposit peritoneal seeding, resection and intraperitoneal chemotherapy. West Indian Med J; 2005 Sep;54(4):242-6
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  • [Title] Carcinoma of the jejunum with multideposit peritoneal seeding, resection and intraperitoneal chemotherapy.
  • Intraperitoneal chemotherapy (IPC) has been shown in non-randomized studies to improve the survival of patients presenting with intraperitoneal metastases from carcinoma of the colon, appendix and stomach and in primary peritoneal malignancies including mesothelioma and pseudomyxoma peritonei, providing that adequate operative cytoreduction can be performed.

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  • (PMID = 16312191.001).
  • [ISSN] 0043-3144
  • [Journal-full-title] The West Indian medical journal
  • [ISO-abbreviation] West Indian Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Jamaica
  • [Chemical-registry-number] Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil
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11. Oge T, Zeck W, Tamussino K: An adenocarcinoid tumour of the appendix mimicking advanced ovarian carcinoma. J Obstet Gynaecol; 2009 Nov;29(8):780-1
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  • [Title] An adenocarcinoid tumour of the appendix mimicking advanced ovarian carcinoma.
  • [MeSH-major] Appendiceal Neoplasms / diagnosis. Carcinoid Tumor / diagnosis. Carcinoma / diagnosis. Ovarian Neoplasms / diagnosis
  • [MeSH-minor] Appendix / pathology. Appendix / surgery. Diagnosis, Differential. Female. Humans. Middle Aged. Ovary / pathology. Treatment Outcome

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  • (PMID = 19821688.001).
  • [ISSN] 1364-6893
  • [Journal-full-title] Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology
  • [ISO-abbreviation] J Obstet Gynaecol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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12. Wang HL, Dhall D: Goblet or signet ring cells: that is the question. Adv Anat Pathol; 2009 Jul;16(4):247-54
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  • Goblet cell carcinoid tumor is a rare mixed endocrine-exocrine neoplasm of the appendix.
  • A recent retrospective study of a large number of appendiceal goblet cell carcinoids has shown that these tumors can be stratified into 3 subgroups based on careful histologic analysis: typical goblet cell carcinoid (group A); adenocarcinoma ex goblet cell carcinoid, signet ring cell type (group B); and adenocarcinoma ex goblet cell carcinoid, poorly differentiated carcinoma type (group C).
  • [MeSH-major] Adenocarcinoma / pathology. Appendiceal Neoplasms / pathology. Carcinoid Tumor / pathology. Carcinoma, Signet Ring Cell / pathology. Goblet Cells / pathology

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  • (PMID = 19546612.001).
  • [ISSN] 1533-4031
  • [Journal-full-title] Advances in anatomic pathology
  • [ISO-abbreviation] Adv Anat Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 11
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13. Terada T: Non-invasive Adenocarcinoma of the Vermiform Appendix: Incidence and Report of Four Cases among 512 Appendectomies. Gastroenterology Res; 2009 Aug;2(4):238-241
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  • [Title] Non-invasive Adenocarcinoma of the Vermiform Appendix: Incidence and Report of Four Cases among 512 Appendectomies.
  • : Tumors of the vermiform appendix are relatively rare.
  • The results suggest that incidence of appendiceal adenocarcinoma was 0.8% of all appendectomies, and that non-invasive adenocarcinoma of the appendix shows variable morphologies, and that postoperative clinical outcome of non-invasive appendiceal tumor is good.

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  • (PMID = 27942282.001).
  • [ISSN] 1918-2805
  • [Journal-full-title] Gastroenterology research
  • [ISO-abbreviation] Gastroenterology Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Keywords] NOTNLM ; Adenocarcinoma / Appendix / Histopathology / Non-invasive carcinoma / appendicitis
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14. Abdu B, Hobgood D, Stallings S, Depasquale S: Incidental finding of pseudomyxoma peritonei at primary cesarean section. Am J Perinatol; 2009 Oct;26(9):633-5
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  • Primary appendiceal carcinoma is extremely rare and is found in approximately 1% of appendectomy specimens.
  • When cancer is present, the most frequent histology is mucinous adenocarcinoma.
  • Neoplasms of the appendix that secrete mucin such as adenocarcinoma may rupture, leading to intraperitoneal seeding of the peritoneum and producing the clinical picture of pseudomyxoma peritonei (PMP).
  • A general surgeon was consulted, and grossly necrotic-appearing appendix was noted.
  • Pathology showed well-differentiated mucinous adenocarcinoma of the appendix.
  • Early diagnosis of a potentially life-threatening disease requires that clinicians expand the differential diagnosis and consider the possibility of a malignant neoplasm presenting in the pregnant female.

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  • [Copyright] Thieme Medical Publishers.
  • (PMID = 19399708.001).
  • [ISSN] 1098-8785
  • [Journal-full-title] American journal of perinatology
  • [ISO-abbreviation] Am J Perinatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 14
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15. Yemelyanova AV, Vang R, Judson K, Wu LS, Ronnett BM: Distinction of primary and metastatic mucinous tumors involving the ovary: analysis of size and laterality data by primary site with reevaluation of an algorithm for tumor classification. Am J Surg Pathol; 2008 Jan;32(1):128-38
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  • Distinction of primary ovarian mucinous tumors from metastatic/secondary mucinous tumors involving the ovaries is often challenging, not only at the time of intraoperative assessment when requested for surgical management (staging decisions) but also for final pathologic diagnosis.
  • To assess the general utility of this algorithm for distinction of primary and secondary mucinous tumors in the ovary and address the occurrence of exceptions (large unilateral metastases), analysis of tumor size and laterality data was performed using 194 tumors (52 primary tumors and 142 metastases), with metastases subclassified by primary site [colorectum (46), appendix (28 low-grade tumors, 20 carcinomas), pancreaticobiliary tract (20), small intestine (3), stomach (5), and endocervix (20)].
  • Recognition that metastatic colorectal carcinomas represent the most common metastases and have a greater tendency to violate the algorithm should prompt lowering of the threshold for suggesting the possibility of metastatic colorectal carcinoma for tumors displaying any microscopic features suggestive of that diagnosis, even when a history of primary colorectal carcinoma is lacking.

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  • (PMID = 18162780.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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16. Gramann T, Matter L, Pfofe D, Flury R, Jaeger P: [Metastazation into the seminal vesicles due to primary goblet cell carcinoid of the vermiform appendix. An unusual diagnostic procedure of a seminal vesicle tumor]. Urologe A; 2009 Nov;48(11):1352-5
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  • [Title] [Metastazation into the seminal vesicles due to primary goblet cell carcinoid of the vermiform appendix. An unusual diagnostic procedure of a seminal vesicle tumor].
  • [Transliterated title] Samenblasenmetastase bei primärem Becherzellkarzinoid der Appendix vermiformis. Ein aussergewöhnlicher Abklärungsgang eines Samenblasentumors.
  • According to a transrectal ultrasound-guided punch biopsy the patient was suspected of having a carcinoma of the seminal vesicles and an aggressive operational approach was considered.
  • A goblet cell carcinoid of the vermiform appendix was identified as the primary tumor.
  • This case report deals with metastazation of a primary goblet cell carcinoma into the seminal vesicles on both sides as an extremely rare reason for suspicious rectal palpation results.
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / adverse effects. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Appendectomy. Appendix / pathology. Biomarkers, Tumor / analysis. Biopsy. Combined Modality Therapy. Diagnosis, Differential. Digital Rectal Examination. Fluorouracil / administration & dosage. Fluorouracil / adverse effects. Humans. Leucovorin / administration & dosage. Leucovorin / adverse effects. Magnetic Resonance Imaging. Male. Middle Aged. Organoplatinum Compounds / administration & dosage. Organoplatinum Compounds / adverse effects. Palliative Care. Patient Care Team. Peritoneal Neoplasms / pathology. Peritoneal Neoplasms / secondary. Synaptophysin / analysis

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  • (PMID = 19705095.001).
  • [ISSN] 1433-0563
  • [Journal-full-title] Der Urologe. Ausg. A
  • [ISO-abbreviation] Urologe A
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Organoplatinum Compounds; 0 / Synaptophysin; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; Folfox protocol
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17. Matsui H, Igarashi N, Okamura A, Itano O, Koyama Y, Miyakita M: Laparoscopy-assisted resection of an appendiceal mucinous cystadenoma. Tokai J Exp Clin Med; 2007 Dec;32(4):140-3
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  • We present a 48-year-old man with a complaint of dull right-lower abdominal pain who was diagnosed with mucocele of the appendix.
  • The pathological diagnosis of the tumor was mucinous cystadenoma of the appendix, measuring 9.0 cm × 8.0 cm × 4.0 cm.
  • (2) to consider the extent of tumor resection with a negative surgical margin as well as prophylactic lymph node dissection in cases of suspected adenocarcinoma, even though the oncological adequacy of the laparoscopic procedure for carcinoma remains to be elucidated; and (3) to check whether any mucinous fluid has accumulated in the abdominal cavity, which represents an indication for open surgery.

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  • (PMID = 21318954.001).
  • [ISSN] 2185-2243
  • [Journal-full-title] The Tokai journal of experimental and clinical medicine
  • [ISO-abbreviation] Tokai J. Exp. Clin. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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18. Louthan O: [Neuroendocrine tumours of the appendix]. Vnitr Lek; 2009 Nov;55(11):1051-5
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  • [Title] [Neuroendocrine tumours of the appendix].
  • According to WHO, neuroendocrine tumors of the appendix (appendiceal carcinoids) are defined as 1. well-differentiated endocrine tumors with benign or uncertain behavior, 2. well-differentiated endocrine carcinoma and 3. goblet cell carcinoma.

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  • (PMID = 20017436.001).
  • [ISSN] 0042-773X
  • [Journal-full-title] Vnitr̆ní lékar̆ství
  • [ISO-abbreviation] Vnitr Lek
  • [Language] cze
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Czech Republic
  • [Number-of-references] 26
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19. Stang A, Kluttig A: Etiologic insights from surface adjustment of colorectal carcinoma incidences: an analysis of the U.S. SEER data 2000-2004. Am J Gastroenterol; 2008 Nov;103(11):2853-61
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  • [Title] Etiologic insights from surface adjustment of colorectal carcinoma incidences: an analysis of the U.S. SEER data 2000-2004.
  • BACKGROUND AND AIMS: The subsite-specific comparison of the incidence of carcinoma within the colorectum is complicated because the mucosal surface, and therefore the amount of epithelial cells at risk, varies among the subsites.
  • The aim of this study was to provide the subsite-specific estimates of the colon mucosal surface and the mucosal surface-adjusted carcinoma incidence estimates of colon subsites that allow a more valid comparison of the subsite-specific incidences.
  • METHODS: We extracted subsite-specific incidence rates of colorectal carcinoma from the Surveillance, Epidemiology, and End Results (SEER) Program of the years 2000-2004.
  • Within the colon, the surface-adjusted rates tend to be highest in the cecum, followed by the vermiform appendix, ascending colon, and sigmoid colon.
  • The surfaced-adjusted incidence of rectal carcinoma is about 12- to 23-fold higher than the rate of carcinoma of the transverse colon.
  • Similar surface-adjusted rates of the vermiform appendix and ascending colon may implicate that these subsites share a similar etiology.

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  • (PMID = 18759825.001).
  • [ISSN] 1572-0241
  • [Journal-full-title] The American journal of gastroenterology
  • [ISO-abbreviation] Am. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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20. Delfosse V, Dome F, Detrembleur N, Wetz P, Boniver J, Fridman V: [Neuroendocrine tumors of the appendix]. Rev Med Liege; 2009 Jul-Aug;64(7-8):361-5
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  • [Title] [Neuroendocrine tumors of the appendix].
  • [Transliterated title] Tumeurs neuroendocrines appendiculaires: à propos d'un cas, de l'histologie à la thérapeutique.
  • The histological study of the appendix revealed a tubular variant of endocrine carcinoma of the appendix.
  • Neuroendocrine tumors ("NETs") of the appendix are rare tumors which are usually detected incidentally, affecting 0.3% to 0.9% of appendectomies.
  • [MeSH-major] Appendectomy. Appendiceal Neoplasms / pathology. Appendiceal Neoplasms / surgery. Carcinoma, Neuroendocrine / pathology. Carcinoma, Neuroendocrine / surgery
  • [MeSH-minor] Appendicitis / etiology. Appendicitis / pathology. Appendicitis / surgery. Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Neuroendocrine Tumors / pathology. Neuroendocrine Tumors / surgery. Prognosis. Treatment Outcome. Young Adult

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  • (PMID = 19777911.001).
  • [ISSN] 0370-629X
  • [Journal-full-title] Revue médicale de Liège
  • [ISO-abbreviation] Rev Med Liege
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Belgium
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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21. McQuellon RP, Russell GB, Shen P, Stewart JH 4th, Saunders W, Levine EA: Survival and health outcomes after cytoreductive surgery with intraperitoneal hyperthermic chemotherapy for disseminated peritoneal cancer of appendiceal origin. Ann Surg Oncol; 2008 Jan;15(1):125-33
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  • [Title] Survival and health outcomes after cytoreductive surgery with intraperitoneal hyperthermic chemotherapy for disseminated peritoneal cancer of appendiceal origin.
  • METHODS: Patients underwent cytoreductive surgery and intraperitoneal hyperthermic chemotherapy for peritoneal cancer.
  • Patients completed questionnaires consisting of demographic information and the Functional Assessment of Cancer Therapy, the SF-36 Medical Outcomes Study survey, the Center for Epidemiologic Studies-Depression Scale, and the ECOG Performance Status Rating before (T1) and after surgery at 3 (T2), 6 (T3), 12 (T4), and 24 (T5) months.
  • CONCLUSIONS: Although complications can affect short-term recovery, survival in appendix cancer patients with peritoneal cancer is good and for some can be achieved without major decrements in QOL at 1 year.
  • [MeSH-major] Adenocarcinoma / mortality. Appendiceal Neoplasms / mortality. Chemotherapy, Cancer, Regional Perfusion. Hyperthermia, Induced. Peritoneal Neoplasms / mortality

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  • (PMID = 18030535.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / K08 CA131482
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 50SG953SK6 / Mitomycin
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22. Rosato L, De Tomaa G, Mondini G, Bertone P, Fornari F, Orlassino R: [Neurendocrine tumours of the appendix, colon and rectum: current surgical aspects]. Chir Ital; 2007 Jul-Aug;59(4):445-52
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  • [Title] [Neurendocrine tumours of the appendix, colon and rectum: current surgical aspects].
  • [Transliterated title] Attualità nella chirurgia dei tumori neuroendocrini dell'appendice, del colon e del retto.
  • Over the period from 1996 to 2005 42 patients with gastroenteropancreatic (GEP) NET were observed (M.F ratio: 1.5:1; mean age 58 years; > 60 years for all localisations except the appendix [< 39 years]).
  • Twenty-three were tumours of the appendix, colon and rectum, corresponding to 55% of all those affecting the digestive tract: 8 appendix (35%), 6 right colon (26%), 4 left colon (17%) and 5 rectum (22%).
  • The NET diagnosis was formulated in all cases on the basis of histological and immunohistochemical examinations.
  • NET of the appendix, colon and rectum are rare, despite being the most frequent among the GEP tumours, and are difficult to diagnose, and therefore sometimes pose problems of surgical therapy, which, when performed in time, may be curative.
  • NET of the appendix measuring <2 cm, localised in the distal part without local infiltration, can be treated by simple appendicectomy and removal of the mesenteriole; otherwise, right hemicolectomy is indicated.
  • Tumours measuring >2 cm or presenting muscular invasion and/or lymph-node metastases (malignant carcinoids), regardless of tumour diameter, are submitted to radical operations, as in the case of carcinoma of the rectum.

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  • (PMID = 17966763.001).
  • [ISSN] 0009-4773
  • [Journal-full-title] Chirurgia italiana
  • [ISO-abbreviation] Chir Ital
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Hormones; 51110-01-1 / Somatostatin
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23. Piña-Oviedo S, Del Valle L, de Leon-Bojorge B, Ortiz-Hidalgo C: 'Signet-ring' cell gastric adenocarcinoma metastatic to a neurogenous hyperplasia of the appendix. Histopathology; 2007 Apr;50(5):663-5
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  • [Title] 'Signet-ring' cell gastric adenocarcinoma metastatic to a neurogenous hyperplasia of the appendix.
  • [MeSH-major] Appendiceal Neoplasms / secondary. Appendix / pathology. Carcinoma, Signet Ring Cell / secondary. Neoplasms, Multiple Primary / pathology. Neuroma / pathology. Stomach Neoplasms / pathology

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  • (PMID = 17394504.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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24. Taverna G, Corinti M, Colombo P, Grizzi F, Severo M, Piccinelli A, Giusti G, Benetti A, Zucali PA, Graziotti P: Bladder metastases of appendiceal mucinous adenocarcinoma: a case presentation. BMC Cancer; 2010;10:62
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  • Few cases of appendiceal carcinoma infiltrating the bladder wall for spatial contiguity have been documented.
  • CASE PRESENTATION: A case is reported of a 45-years old woman with mucinous cystadenocarcinoma of the appendix with bladder metastasis.
  • Laparotomy evidenced the presence of a solid mass of the appendix (2,5 cm x 3 cm x 2 cm) extending to the loco-regional lymph nodes.
  • The subsequent pathological examination revealed a mucinous cystadenocarcinoma of the appendix with metastatic cells colonising the anterior bladder wall and several colic lymph nodes.
  • CONCLUSIONS: The rarity of the appendiceal carcinoma invading the urinary bladder and its usual involvement of nearest organs and the posterior bladder wall, led us to describe this case which demonstrates the ability of the appendiceal cancer to metastasize different regions of urinary bladder.

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  • [Cites] Int J Urol. 2001 Apr;8(4):196-8 [11260355.001]
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  • (PMID = 20178637.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2836301
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25. Kuester D, Dalicho S, Mönkemüller K, Benedix F, Lippert H, Guenther T, Roessner A, Meyer F: Synchronous multifocal colorectal carcinoma in a patient with delayed diagnosis of ulcerative pancolitis. Pathol Res Pract; 2008;204(12):905-10
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  • [Title] Synchronous multifocal colorectal carcinoma in a patient with delayed diagnosis of ulcerative pancolitis.
  • Patients with ulcerative colitis face an increased lifetime risk of developing colorectal cancer.
  • Regardless of the diagnosis and medical advice, the patient initially refused therapy, and proctocolectomy was delayed for 12 months.
  • Furthermore, a mucinous cystadenoma was found in the appendix in the setting of ulcerative colitis.

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  • [CommentIn] Zentralbl Chir. 2015 Dec;140(6):624-6 [25076166.001]
  • (PMID = 18842350.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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26. Benedix F, Reimer A, Gastinger I, Mroczkowski P, Lippert H, Kube R, Study Group Colon/Rectum Carcinoma Primary Tumor: Primary appendiceal carcinoma--epidemiology, surgery and survival: results of a German multi-center study. Eur J Surg Oncol; 2010 Aug;36(8):763-71
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  • [Title] Primary appendiceal carcinoma--epidemiology, surgery and survival: results of a German multi-center study.
  • BACKGROUND: While carcinoma of the colon is a common malignancy, primary carcinoma of the appendix is rare.
  • METHODS: During a five-year period, 196 consecutive patients with malignant appendiceal tumors were distributed into four groups: appendiceal carcinoids, adenocarcinoma, mucinous adenocarcinoma and adenosquamous carcinoma.
  • Among all appendiceal neoplasms, adenosquamous carcinoma is the rarest histological subtype which is most commonly associated with advanced tumor stage and worst prognosis.
  • [MeSH-minor] Adenocarcinoma / epidemiology. Adenocarcinoma / surgery. Adenocarcinoma, Mucinous / epidemiology. Adenocarcinoma, Mucinous / surgery. Adult. Aged. Appendicitis / diagnosis. Carcinoid Tumor / epidemiology. Carcinoid Tumor / surgery. Carcinoma, Adenosquamous / epidemiology. Carcinoma, Adenosquamous / surgery. Diagnosis, Differential. Female. Germany. Humans. Male. Middle Aged. Neoplasm Staging. Unnecessary Procedures / statistics & numerical data

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  • [Copyright] Copyright (c) 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20561765.001).
  • [ISSN] 1532-2157
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] England
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27. Yajima N, Wada R, Yamagishi S, Mizukami H, Itabashi C, Yagihashi S: Immunohistochemical expressions of cytokeratins, mucin core proteins, p53, and neuroendocrine cell markers in epithelial neoplasm of appendix. Hum Pathol; 2005 Nov;36(11):1217-25
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  • [Title] Immunohistochemical expressions of cytokeratins, mucin core proteins, p53, and neuroendocrine cell markers in epithelial neoplasm of appendix.
  • Epithelial neoplasms of appendix are infrequent, and their pathological features are not fully characterized.
  • Although chromogranin A-positive cells are generally sparse in normal appendix, they were more common in mucinous tumors than in nonmucinous tumors.
  • Contrary to the previous data reported (Mod Pathol 2002;15:599-605), mucinous carcinoma exhibited a higher frequency of p53-positive cells (mean 29%) compared with mucinous adenoma (2.8%) (P < .001), whereas nonmucinous tumors showed high levels of p53-positive cells to similar extent (51%-67%) in both adenoma and carcinoma.
  • This is the first report that characterized the immunophenotypic profile of appendiceal epithelial neoplasms with an emphasis of a higher frequency of p53 positivity in mucinous carcinoma cases compared with mucinous adenoma in the appendix.


28. Colović R, Grubor N, Micev M, Latincić S, Matić S, Colović N: [Actinomycosis of the caecum simulating carcinoma in a patient with a long-term intrauterine device]. Srp Arh Celok Lek; 2009 May-Jun;137(5-6):285-7
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  • [Title] [Actinomycosis of the caecum simulating carcinoma in a patient with a long-term intrauterine device].
  • Due to the tumorous lesions involving the terminal ileum, appendix, caecum, ascending colon and omentum, a right hemicolectomy was performed.
  • Based on histolopathological findings of the resected sample the diagnosis of actinomycosis was made.
  • CONCLUSION: Although rare, actinomycosis of the caecum should be taken into consideration in the differential diagnosis of tumorous lesions of the caecoascending part of the colon, particularly if the tumour is associated with inflammation.
  • [MeSH-major] Actinomycosis / diagnosis. Cecal Diseases / diagnosis. Cecal Neoplasms / diagnosis. Intrauterine Devices / adverse effects
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans

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  • (PMID = 19594073.001).
  • [ISSN] 0370-8179
  • [Journal-full-title] Srpski arhiv za celokupno lekarstvo
  • [ISO-abbreviation] Srp Arh Celok Lek
  • [Language] srp
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Serbia
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29. Eveno C, Dagois S, Guillot E, Gornet JM, Pocard M: [Treatment of peritoneal carcinomatosis with surgery and hyperthermic peroperative intraperitoneal chemotherapy (HIPEC): new aspects and validated indications]. Bull Cancer; 2008 Jan;95(1):141-5
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  • [Transliterated title] Traitement des carcinoses péritonéales par chirurgie et chimiothérapie hyperthermique intrapéritonéale peropératoire (Chip): des nouveautés mais aussi des indications validées.
  • Four indications are recognized by some tree national evaluation committees: the French ANAES, the British NICE and the Canadian CEPO: colorectal carcinoma, carcinoma of the appendix, pseudomyxoma peritonei and mesothelioma.
  • [MeSH-major] Antineoplastic Agents / administration & dosage. Carcinoma / therapy. Chemotherapy, Cancer, Regional Perfusion / methods. Hyperthermia, Induced. Peritoneal Neoplasms / therapy

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  • (PMID = 18230580.001).
  • [ISSN] 1769-6917
  • [Journal-full-title] Bulletin du cancer
  • [ISO-abbreviation] Bull Cancer
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 26
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30. Kinová S, Kekenák L, Kovácová E, Koren M: [Gastroenteropatic neuroendocrine tumors: multidisciplinary approach in therapy]. Vnitr Lek; 2010 Sep;56(9 Suppl):946-50
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  • Primary localisation was: stomach--6 times, pancreas--9 times, duodenum--1 times, jejunum-- 4 times, appendix--3 times, ileum--23 times, rectum--4 times.
  • Metastatic disease was affirmed in time of diagnosis in 36 patients.
  • In 5 pts with non resectable neuroendocrine carcinoma of pancreas peptid radionuclide receptor therapy (PRRT) was indicated: in 4 of them with 90Ytrium-DOTA-octreotid and in 1 patient with MIBG.

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  • (PMID = 21137165.001).
  • [ISSN] 0042-773X
  • [Journal-full-title] Vnitr̆ní lékar̆ství
  • [ISO-abbreviation] Vnitr Lek
  • [Language] slo
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Czech Republic
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31. Heinzelmann-Schwarz VA, Scolyer RA, Scurry JP, Smith AN, Gardiner-Garden M, Biankin AV, Baron-Hay S, Scott C, Ward RL, Fink D, Hacker NF, Sutherland RL, O'Brien PM: Low meprin alpha expression differentiates primary ovarian mucinous carcinoma from gastrointestinal cancers that commonly metastasise to the ovaries. J Clin Pathol; 2007 Jun;60(6):622-6
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  • [Title] Low meprin alpha expression differentiates primary ovarian mucinous carcinoma from gastrointestinal cancers that commonly metastasise to the ovaries.
  • BACKGROUND: Currently, no specific immunohistochemical markers are available to differentiate primary mucinous epithelial ovarian cancer (MOC) from adenocarcinomas originating at other sites that have metastasised to the ovary, which may have an impact on patient management and prognosis.
  • METHODS: Using immunohistochemical analysis, the expression of galectin 4 and meprin alpha was investigated in 10 MOCs and in 38 mucinous adenocarcinomas of colon, pancreas, stomach and appendix, the most common sites of origin of ovarian metastases.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Biomarkers, Tumor / metabolism. Gastrointestinal Neoplasms / pathology. Metalloendopeptidases / metabolism. Ovarian Neoplasms / diagnosis
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / metabolism. Adenocarcinoma / secondary. Diagnosis, Differential. Female. Galectin 4 / metabolism. Humans. Immunoenzyme Techniques. Keratin-20 / metabolism. Keratin-7 / metabolism. Neoplasm Proteins / metabolism

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  • [Cites] Int J Gynecol Pathol. 2004 Jan;23(1):52-7 [14668551.001]
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  • (PMID = 16822880.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Galectin 4; 0 / Keratin-20; 0 / Keratin-7; 0 / Neoplasm Proteins; EC 3.4.24.- / Metalloendopeptidases; EC 3.4.24.18 / meprin A
  • [Other-IDs] NLM/ PMC1955076
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32. Bair MJ, Lee PH, Chan YJ: Urologic manifestations of acute appendicitis secondary to metastatic cervical cancer. J Formos Med Assoc; 2007 Sep;106(9):784-7
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  • [Title] Urologic manifestations of acute appendicitis secondary to metastatic cervical cancer.
  • Acute appendicitis, a common entity in differential diagnosis, may present with diverse clinical manifestations.
  • We report a 34-year-old woman who had undergone radical hysterectomy 2 years previously for stage Ib cervical cancer.
  • Computed tomography revealed an enlarged appendix surrounded by an abscess, and appendectomy was performed.
  • Pathologic examination of the surgical specimen revealed metastatic cervical cancer in the appendix.


33. Timofeev J, Galgano MT, Stoler MH, Lachance JA, Modesitt SC, Jazaeri AA: Appendiceal pathology at the time of oophorectomy for ovarian neoplasms. Obstet Gynecol; 2010 Dec;116(6):1348-53
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  • Observations were stratified based on the nature (benign, borderline, or malignant) and histology (serous compared with mucinous) of the ovarian neoplasm, frozen compared with final pathological diagnosis, and the gross appearance of the appendix.
  • Linear regression analysis revealed that appearance of the appendix and frozen section diagnosis of the ovarian pathology were statistically significant predictors of coexisting appendiceal pathology, but the latter was more important.
  • CONCLUSION: The prevalence of coexisting, clinically significant appendiceal pathology is low with a frozen section diagnosis of serous or mucinous cystadenoma.
  • Appendectomy is recommended when frozen section diagnosis is mucinous or serous ovarian carcinoma, borderline tumor or metastatic carcinoma of suspected gastrointestinal origin.
  • [MeSH-minor] Adult. Appendiceal Neoplasms / diagnosis. Appendiceal Neoplasms / secondary. Appendiceal Neoplasms / surgery. Appendix / pathology. Cecal Diseases / complications. Cecal Diseases / diagnosis. Cecal Diseases / surgery. Female. Frozen Sections. Humans. Middle Aged

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  • (PMID = 21099601.001).
  • [ISSN] 1873-233X
  • [Journal-full-title] Obstetrics and gynecology
  • [ISO-abbreviation] Obstet Gynecol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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34. Agaimy A, Pelz AF, Wieacker P, Roessner A, Wünsch PH, Schneider-Stock R: Gastrointestinal stromal tumors of the vermiform appendix: clinicopathologic, immunohistochemical, and molecular study of 2 cases with literature review. Hum Pathol; 2008 Aug;39(8):1252-7
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  • [Title] Gastrointestinal stromal tumors of the vermiform appendix: clinicopathologic, immunohistochemical, and molecular study of 2 cases with literature review.
  • Gastrointestinal stromal tumors (GIST) are rare in the vermiform appendix.
  • Here, we report 2 appendiceal gastrointestinal stromal tumors in a 78-year-old woman and a 72-year-old man with a history of endometrial adenocarcinoma and urinary bladder carcinoma, respectively.
  • Both gastrointestinal stromal tumors were incidental findings at surgery for appendicitis-like symptoms and on follow-up for bladder carcinoma, respectively.

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  • (PMID = 18547614.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
  • [Number-of-references] 21
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35. Tannapfel A, Wittekind C: [The current TNM system for gastrointestinal tumors part II]. Pathologe; 2010 Sep;31(5):348-52
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  • Major and praxis-relevant alterations concern colorectal tumours and include new classifications of carcinomas and carcinoids of the appendix.
  • [MeSH-minor] Ampulla of Vater / pathology. Appendiceal Neoplasms / classification. Appendiceal Neoplasms / pathology. Carcinoid Tumor / classification. Carcinoid Tumor / pathology. Carcinoma, Hepatocellular / classification. Carcinoma, Hepatocellular / pathology. Cholangiocarcinoma / classification. Cholangiocarcinoma / pathology. Colorectal Neoplasms / classification. Colorectal Neoplasms / pathology. Common Bile Duct Neoplasms / pathology. Disease Progression. Gallbladder Neoplasms / classification. Gallbladder Neoplasms / pathology. Gastrointestinal Stromal Tumors / classification. Gastrointestinal Stromal Tumors / pathology. Humans. Lymphatic Metastasis / pathology. Mitotic Index. Neoplasm Invasiveness / pathology. Neuroendocrine Tumors / classification. Neuroendocrine Tumors / pathology. Pancreatic Neoplasms / classification. Pancreatic Neoplasms / pathology. Prognosis. Rectal Neoplasms / classification. Rectal Neoplasms / pathology

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  • [CommentIn] Pathologe. 2010 Sep;31(5):353-4 [20809402.001]
  • [Cites] Virchows Arch. 2006 Oct;449(4):395-401 [16967267.001]
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  • (PMID = 20798945.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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36. Conlon JM: Granin-derived peptides as diagnostic and prognostic markers for endocrine tumors. Regul Pept; 2010 Nov 30;165(1):5-11
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  • However, circulating concentrations of CgA-LI are elevated in several non-neoplastic diseases and in patients receiving acid-suppression therapy which may lead to false positive diagnosis.
  • Antisera to the secretogranin II-derived peptide, secretoneurin detects carcinoid tumors of the appendix with greater frequency than antisera to CgA and are of value in identifying therapy-resistant carcinoma of the prostate (clinical stage D3).
  • [MeSH-major] Chromogranins / metabolism. Endocrine Gland Neoplasms / diagnosis. Endocrine Gland Neoplasms / pathology

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  • [Copyright] Copyright © 2009 Elsevier B.V. All rights reserved.
  • (PMID = 19931574.001).
  • [ISSN] 1873-1686
  • [Journal-full-title] Regulatory peptides
  • [ISO-abbreviation] Regul. Pept.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Chromogranin A; 0 / Chromogranin B; 0 / Chromogranins; 0 / Secretogranin II
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37. Plöckinger U, Couvelard A, Falconi M, Sundin A, Salazar R, Christ E, de Herder WW, Gross D, Knapp WH, Knigge UP, Kulke MH, Pape UF, Frascati Consensus Conference participants: Consensus guidelines for the management of patients with digestive neuroendocrine tumours: well-differentiated tumour/carcinoma of the appendix and goblet cell carcinoma. Neuroendocrinology; 2008;87(1):20-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Consensus guidelines for the management of patients with digestive neuroendocrine tumours: well-differentiated tumour/carcinoma of the appendix and goblet cell carcinoma.
  • [MeSH-major] Appendiceal Neoplasms / therapy. Carcinoma / therapy. Consensus. Goblet Cells. Guidelines as Topic / standards

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  • [CommentIn] Neuroendocrinology. 2013;98(2):170 [24298561.001]
  • [CommentIn] Neuroendocrinology. 2013;98(2):170 [24135761.001]
  • (PMID = 17934252.001).
  • [ISSN] 1423-0194
  • [Journal-full-title] Neuroendocrinology
  • [ISO-abbreviation] Neuroendocrinology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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38. Hasui K, Murata F: A new simplified catalyzed signal amplification system for minimizing non-specific staining in tissues with supersensitive immunohistochemistry. Arch Histol Cytol; 2005;68(1):1-17
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  • By this method, the Ki67 antigen in the G1 phase cell cycle could be detected and a metabolic disorder of the Ki67 antigen was implicated in a carcinoid tumor in the stomach.
  • [MeSH-minor] Appendix / chemistry. Appendix / ultrastructure. Carcinoid Tumor / chemistry. Carcinoid Tumor / ultrastructure. Carcinoma, Hepatocellular / chemistry. Carcinoma, Hepatocellular / ultrastructure. Carcinoma, Squamous Cell / chemistry. Carcinoma, Squamous Cell / ultrastructure. Caseins / chemistry. Fluorescent Dyes / chemistry. G1 Phase. Humans. Ki-67 Antigen / analysis. Liver Neoplasms / chemistry. Liver Neoplasms / ultrastructure. Lymph Nodes / chemistry. Lymph Nodes / ultrastructure. Polyethylene Glycols. Sensitivity and Specificity. Serum Albumin, Bovine / chemistry. Stomach Neoplasms / chemistry. Stomach Neoplasms / ultrastructure. Tongue Neoplasms / chemistry. Tongue Neoplasms / ultrastructure

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  • (PMID = 15827374.001).
  • [ISSN] 0914-9465
  • [Journal-full-title] Archives of histology and cytology
  • [ISO-abbreviation] Arch. Histol. Cytol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Caseins; 0 / FITC-tyramide; 0 / Fluorescent Dyes; 0 / Ki-67 Antigen; 0 / Serum Albumin, Bovine; 0 / biotinyltyramide; 30IQX730WE / Polyethylene Glycols; 6SO6U10H04 / Biotin; I223NX31W9 / Fluorescein-5-isothiocyanate; X8ZC7V0OX3 / Tyramine
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39. Chua TC, Martin S, Saxena A, Liauw W, Yan TD, Zhao J, Lok I, Morris DL: Evaluation of the cost-effectiveness of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (peritonectomy) at the St George Hospital peritoneal surface malignancy program. Ann Surg; 2010 Feb;251(2):323-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: The average cost of CRS and HIPEC per patient and per life year for appendix cancer is AUD $88,423 (range, AUD $23,933-AUD $299,145) and AUD $37,737/LY; for colorectal cancer is AUD $66,148 (range, AUD $26,079-AUD $409,666) and AUD $29,757/LY; for pseudomyxoma peritonei is AUD $92,308 (range, AUD $11,562-AUD $501,144) and AUD $29,559/LY; for peritoneal mesothelioma is AUD $55,062 (range, AUD $23,261-AUD $94,104) and AUD $20,521/LY; and for other peritoneal surface malignancies is AUD $44,668 (range, AUD $31,592-AUD $70,026) and AUD $22,091/LY.
  • [MeSH-major] Carcinoma / economics. Carcinoma / therapy. Chemotherapy, Cancer, Regional Perfusion / economics. Hyperthermia, Induced / economics. Peritoneal Neoplasms / economics. Peritoneal Neoplasms / therapy

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  • (PMID = 20040853.001).
  • [ISSN] 1528-1140
  • [Journal-full-title] Annals of surgery
  • [ISO-abbreviation] Ann. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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40. Mastoraki A, Papanikolaou IS, Kanakis D, Safioleas P, Sakorafas G, Safioleas M: A case of signet ring carcinoma of the appendix: dilemmas in differential diagnosis and management. J Gastrointest Cancer; 2010 Jun;41(2):141-4
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  • [Title] A case of signet ring carcinoma of the appendix: dilemmas in differential diagnosis and management.
  • PURPOSE: Signet ring carcinoma (SRC) of the appendix consists one of the most biologically virulent cancers.
  • We present the case of a patient with primary SRC complicated by the development of acute inflammation of the appendix.
  • Laparotomy confirmed a tumor mass which appeared to originate from the appendix.
  • The appendix was notably thickened with an ulcerated wall containing sinus tracts, chronic inflammation, and scarring.
  • CONCLUSIONS: Appendiceal SRC is a rare entity, which may sometimes be confused with other pathologies providing difficulties in differential diagnosis, having an impact on therapeutic decisions and affecting prognosis.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Carcinoma, Signet Ring Cell / pathology
  • [MeSH-minor] Abdominal Pain. Aged. Antimetabolites, Antineoplastic / therapeutic use. Antineoplastic Agents / therapeutic use. Appendicitis / complications. Appendicitis / diagnosis. Appendicitis / surgery. Chemotherapy, Adjuvant. Diagnosis, Differential. Drug Therapy, Combination. Fluorouracil / therapeutic use. Humans. Laparotomy. Leucovorin / therapeutic use. Male. Organoplatinum Compounds / therapeutic use. Vitamin B Complex / therapeutic use. Vomiting

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  • (PMID = 20058100.001).
  • [ISSN] 1941-6636
  • [Journal-full-title] Journal of gastrointestinal cancer
  • [ISO-abbreviation] J Gastrointest Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Antineoplastic Agents; 0 / Organoplatinum Compounds; 04ZR38536J / oxaliplatin; 12001-76-2 / Vitamin B Complex; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil
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41. Agaimy A, Wuensch PH: Gastrointestinal stromal tumours in patients with other-type cancer: a mere coincidence or an etiological association? A study of 97 GIST cases. Z Gastroenterol; 2005 Sep;43(9):1025-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gastrointestinal stromal tumours in patients with other-type cancer: a mere coincidence or an etiological association? A study of 97 GIST cases.
  • 12 GISTs were located in the stomach, four in the small intestine, and one each in the duodenum and the vermiform appendix.
  • Most GISTs (16/18) represented benign or low-risk lesions (innocent bystanders) detected during evaluation for the known cancer, either during staging, intra-operatively or on follow-up.
  • Two women (43 and 72 years old) with large malignant GISTs (10.5 and 12 cm), one of them with two simultaneous hepatic metastases resected at the same time as the primary GIST, developed infiltrating ductal mammary carcinoma and were alive and well 75 and 95 months postoperatively, respectively.
  • Furthermore, one of them developed endometrial carcinoma.
  • We concluded that GISTs are not uncommonly encountered in cancer-patients during staging, intraoperatively or on follow-up and should be considered in the differential diagnosis of newly detected focal lesions to avoid their misinterpretation as metastasis from the known malignancy with consequently false therapeutic decisions.

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  • (PMID = 16142610.001).
  • [ISSN] 0044-2771
  • [Journal-full-title] Zeitschrift für Gastroenterologie
  • [ISO-abbreviation] Z Gastroenterol
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Germany
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42. Djuranovic SP, Spuran MM, Kovacevic NV, Ugljesic MB, Kecmanovic DM, Micev MT: Mucinous cystadenoma of the appendix associated with adenocarcinoma of the sigmoid colon and hepatocellular carcinoma of the liver: report of a case. World J Gastroenterol; 2006 Mar 28;12(12):1975-7
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  • [Title] Mucinous cystadenoma of the appendix associated with adenocarcinoma of the sigmoid colon and hepatocellular carcinoma of the liver: report of a case.
  • Mucinous cystadenoma of the appendix is a rare condition and represents one of the three entities with the common name mucocele of the appendix.
  • He had a big cystadenoma of the appendix associated with adenocarcinoma of the colon and hepatocellular carcinoma of the liver.
  • According to this, we stress the need of accurate preoperative diagnosis and intraoperative exploration of the whole abdomen in these patients.
  • [MeSH-major] Adenocarcinoma / complications. Appendiceal Neoplasms / complications. Carcinoma, Hepatocellular / complications. Cystadenoma, Mucinous / complications. Liver Neoplasms / complications. Sigmoid Neoplasms / complications

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  • (PMID = 16610012.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4087531
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43. Okada N, Ishibashi K, Nakada H, Miyazaki T, Sobajima J, Gonda T, Ishida H: [Five cases of pseudomyxoma peritonei underwent abdominal lavage and administering CDDP]. Gan To Kagaku Ryoho; 2007 Nov;34(12):1955-7
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  • These primary lesions contained one case of pancreas and four cases of appendix.
  • Histological types contained one case of well differentiated adenocarcinoma and four cases of signet ring cell carcinoma.

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  • (PMID = 18219863.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] Q20Q21Q62J / Cisplatin
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44. Bozanović T, Ljubić A, Momcilov P, Mostić T, Vojvodić L, Vidaković S: Synchronous primary tumors: appendiceal and ovarian cancer--case report. Eur J Gynaecol Oncol; 2009;30(2):237-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Synchronous primary tumors: appendiceal and ovarian cancer--case report.
  • Histology revealed synchronous adenocarcinoma of the appendix and serous pappillary carcinoma of the right ovary.
  • [MeSH-major] Adenocarcinoma / pathology. Appendiceal Neoplasms / pathology. Carcinoma, Papillary / pathology. Neoplasms, Multiple Primary / pathology. Ovarian Neoplasms / pathology

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  • (PMID = 19480268.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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45. Tang LH, Shia J, Soslow RA, Dhall D, Wong WD, O'Reilly E, Qin J, Paty P, Weiser MR, Guillem J, Temple L, Sobin LH, Klimstra DS: Pathologic classification and clinical behavior of the spectrum of goblet cell carcinoid tumors of the appendix. Am J Surg Pathol; 2008 Oct;32(10):1429-43
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  • [Title] Pathologic classification and clinical behavior of the spectrum of goblet cell carcinoid tumors of the appendix.
  • The clinical characteristics and prognosis were compared within these groups and with conventional de novo appendiceal adenocarcinomas.
  • [MeSH-major] Adenocarcinoma / pathology. Appendiceal Neoplasms / pathology. Carcinoid Tumor / pathology. Carcinoma, Signet Ring Cell / pathology


46. Villanueva Saenz E, Pérez-Aguirre J, Belmonte MC, Martínez PH, Márquez RM, Carranza RJ: Appendix adenocarcinoma associated with ulcerative colitis: a case report and literature review. Tech Coloproctol; 2006 Mar;10(1):54-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Appendix adenocarcinoma associated with ulcerative colitis: a case report and literature review.
  • Ulcerative colitis (UC) represents a risk factor for colorectal cancer, but the association between UC and appendix cancer is uncommon.
  • Histopathological analysis indicated adenocarcinoma from the cecal appendix, and chronic-active ulcerative colitis of the colon.
  • The appendix adenocarcinoma and ulcerative colitis may or may not be associated, same as colon cancer in patients with UC.


47. Kulkarni D, Pinto DJ: Coexistence of Crohn's disease and neuroendocrine tumour of appendix: more than coincidence? Int J Clin Pract; 2005 Jul;59(7):852-3
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  • [Title] Coexistence of Crohn's disease and neuroendocrine tumour of appendix: more than coincidence?
  • [MeSH-major] Appendiceal Neoplasms / complications. Carcinoma, Neuroendocrine / complications. Crohn Disease / complications

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  • (PMID = 15963215.001).
  • [ISSN] 1368-5031
  • [Journal-full-title] International journal of clinical practice
  • [ISO-abbreviation] Int. J. Clin. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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48. Oya S, Miyata K, Yuasa N, Takeuchi E, Goto Y, Miyake H, Nagasawa K, Kobayashi Y, Ito T, Ito M: Early carcinoma of the appendix vermiformis. Dig Endosc; 2009 Jan;21(1):53-5
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  • [Title] Early carcinoma of the appendix vermiformis.
  • It is difficult to preoperatively diagnose early carcinoma of the vermiform appendix because of its rarity and few specific clinical features.
  • In the present study, we report a preoperatively diagnosed mucosal carcinoma of the vermiform appendix.
  • [MeSH-major] Adenocarcinoma / diagnosis. Appendiceal Neoplasms / diagnosis

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  • (PMID = 19691804.001).
  • [ISSN] 1443-1661
  • [Journal-full-title] Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society
  • [ISO-abbreviation] Dig Endosc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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49. Alsaad KO, Serra S, Perren A, Hsieh E, Chetty R: CK19 and CD99 immunoexpression profile in goblet cell (mucin-producing neuroendocrine tumors) and classical carcinoids of the vermiform appendix. Int J Surg Pathol; 2007 Jul;15(3):252-7
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  • [Title] CK19 and CD99 immunoexpression profile in goblet cell (mucin-producing neuroendocrine tumors) and classical carcinoids of the vermiform appendix.
  • The immunoexpression of CK19 recently has been identified as a marker of poor prognosis in pancreatic endocrine tumors and hepatocellular carcinoma.
  • The purpose of this study was to explore CK19 and CD99 immunostaining in mucin-producing neuroendocrine (goblet cell) and classical carcinoids of the appendix.

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  • (PMID = 17652531.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Biomarkers, Tumor; 0 / CD99 protein, human; 0 / Cell Adhesion Molecules; 0 / Keratin-19
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50. Miller JS, Ramalingam P, Wang BY, Lee JR: Appendiceal mass in a middle-aged woman. Endometrioid endometrial carcinoma metastatic to the appendix. Arch Pathol Lab Med; 2006 Mar;130(3):407-8
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  • [Title] Appendiceal mass in a middle-aged woman. Endometrioid endometrial carcinoma metastatic to the appendix.
  • [MeSH-major] Appendiceal Neoplasms / secondary. Carcinoma, Endometrioid / secondary
  • [MeSH-minor] Adenocarcinoma / pathology. Biomarkers, Tumor / analysis. Diagnosis, Differential. Endometrial Neoplasms / chemistry. Endometrial Neoplasms / pathology. Endometrial Neoplasms / surgery. Female. Humans. Middle Aged. Proto-Oncogene Proteins c-bcl-2 / analysis. Receptors, Estrogen / analysis. Vimentin / analysis

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  • (PMID = 16519577.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Receptors, Estrogen; 0 / Vimentin
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51. O'Kane AM, O'Donnell ME, Shah R, Carey DP, Lee J: Small cell carcinoma of the appendix. World J Surg Oncol; 2008;6:4
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  • [Title] Small cell carcinoma of the appendix.
  • BACKGROUND: An extrapulmonary small cell carcinoma is a rare condition.
  • It has similar histological features to pulmonary small cell carcinoma and is equally aggressive.
  • Exploratory laparotomy and right hemicolectomy was performed with histopathological analysis confirming a primary small cell carcinoma of her appendix.
  • CONCLUSION: This is the first reported case of a pure extrapulmonary carcinoma arising from the appendix.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Carcinoma, Small Cell / secondary. Liver Neoplasms / secondary
  • [MeSH-minor] Appendectomy / methods. Colectomy / methods. Colonoscopy. Diagnosis, Differential. Fatal Outcome. Female. Follow-Up Studies. Humans. Middle Aged. Tomography, X-Ray Computed

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  • [Cites] Neth J Med. 2000 Feb;56(2):51-5 [10710941.001]
  • [Cites] Jpn J Clin Oncol. 2004 May;34(5):250-4 [15231859.001]
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  • (PMID = 18197972.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2241597
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52. Wang GL, Wang MY, Wei WB: [Clinical features and treatment of choroidal metastasis]. Zhonghua Yan Ke Za Zhi; 2009 Mar;45(3):229-33
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Primary tumours were found in 40 cases (81.6%) (surgical excision in 25 cases), consisting of breast carcinoma in 16 cases (32.7%), lung carcinoma in 14 cases (28.6%), hepatoma and cholangiocarcinoma in 3 cases, colon and stomach carcinomas in 3 cases, gynecologic appendix carcinoma (including 1 case of ovarian mucous cyst adenocarcinoma) in 2 cases, nasopharyngeal adenocarcinoma in 1 case, vertebra tumor in 1 case, undetected in 5 cases (10.2%) and under detection in 4 cases (8.2%).
  • The most common primary cancer is breast carcinoma, followed by lung carcinoma.

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  • (PMID = 19575917.001).
  • [ISSN] 0412-4081
  • [Journal-full-title] [Zhonghua yan ke za zhi] Chinese journal of ophthalmology
  • [ISO-abbreviation] Zhonghua Yan Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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53. Chetty R, Klimstra DS, Henson DE, Albores-Saavedra J: Combined classical carcinoid and goblet cell carcinoid tumor: a new morphologic variant of carcinoid tumor of the appendix. Am J Surg Pathol; 2010 Aug;34(8):1163-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Combined classical carcinoid and goblet cell carcinoid tumor: a new morphologic variant of carcinoid tumor of the appendix.
  • Carcinoid tumors are the most common neoplasms of the appendix.
  • In this report, we describe 5 cases of combined classical carcinoid and goblet cell carcinoid (GCC) tumors of the appendix.
  • The tumors (0.6 to 6.0 cm) were located in the mid-portion and the tip of the appendix.
  • The pelvic soft tissue and ovarian metastases in case 4 consisted predominantly of a signet ring cell carcinoma with a minor component of goblet cells and was interpreted as an adenocarcinoma ex-GCC.
  • In view of the fact that these combined carcinoid tumors appear to behave more as goblet cell carcinoids, detailed microscopic examination of classical carcinoid tumors of the appendix is suggested and larger series with longer follow-up is required to ascertain the true biologic potential of this unique form of combined carcinoid tumor of the appendix.

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  • [CommentIn] Am J Surg Pathol. 2011 Aug;35(8):1248-50 [21753706.001]
  • (PMID = 20631606.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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54. Zanati SA, Martin JA, Baker JP, Streutker CJ, Marcon NE: Colonoscopic diagnosis of mucocele of the appendix. Gastrointest Endosc; 2005 Sep;62(3):452-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Colonoscopic diagnosis of mucocele of the appendix.
  • OBSERVATIONS: Seven patients (6 women) with mucocele of the appendix were identified at colonoscopy.
  • No cases revealed carcinoma, and there have been no deaths related to the mucocele.
  • Recognition at colonoscopy is important because it enables accurate diagnosis and directs management.
  • [MeSH-major] Cecal Diseases / diagnosis. Colonoscopy / methods. Mucocele / diagnosis
  • [MeSH-minor] Adult. Aged. Appendectomy / methods. Appendix / pathology. Appendix / surgery. Biopsy, Needle. Female. Follow-Up Studies. Humans. Immunohistochemistry. Incidence. Intestinal Mucosa / pathology. Male. Middle Aged. Retrospective Studies. Risk Assessment. Sensitivity and Specificity. Treatment Outcome

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  • (PMID = 16111974.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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56. Khan MN, Moran BJ: Four percent of patients undergoing colorectal cancer surgery may have synchronous appendiceal neoplasia. Dis Colon Rectum; 2007 Nov;50(11):1856-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Four percent of patients undergoing colorectal cancer surgery may have synchronous appendiceal neoplasia.
  • PURPOSE: An individual with colorectal cancer has a 3 percent risk of synchronous colonic neoplasia and further 2 to 3 percent risk of metachronous cancer, a risk that has prompted colonic surveillance.
  • The appendix has a similar mucosal pattern to the colon and it has been hypothesized that appendicular adenocarcinoma may account for 1 percent of all colorectal malignancies.
  • A special interest of the senior author in appendiceal and rectal cancer has prompted routine removal of the appendix in all cases undergoing surgery for colorectal cancer.
  • METHODS: Consecutive patients undergoing left colectomy or anterior resection for colorectal cancer had coincidental appendectomy with the specimen pathologically analyzed.
  • Data also were collected for patients who had right hemicolectomy for colonic carcinoma.
  • RESULTS: In total, 169 patients under the care of a single surgeon had colorectal cancer resection between April 2002 and April 2005: 63 patients had right hemicolectomy, 29 had left hemicolectomy, and 77 had rectal cancer resection.
  • CONCLUSIONS: Patients having colorectal cancer resection for adenocarcinoma should have appendicectomy performed.
  • Metachronous neoplasia is a risk in the retained appendix in patients with colorectal cancer.

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  • (PMID = 17763906.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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57. Nishio R, Furuya Y, Akashi T, Okumura A, Fuse H: Primary adenocarcinoma of the appendix invading the urinary bladder. Int Urol Nephrol; 2006;38(3-4):481-2
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  • [Title] Primary adenocarcinoma of the appendix invading the urinary bladder.
  • We report a case of adenocarcinoma of the appendix invading the urinary bladder in a 75-year-old man.
  • At operation a primary neoplasm of the appendix invading the bladder was discovered and en bloc resection of the urinary bladder with the adherent cecum followed by an ileocolonic anastomosis and ureterocutaneostomy was performed.
  • The patient died of carcinoma 13 months later.

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  • [Cites] Br J Urol. 1996 Aug;78(2):305-6 [8813936.001]
  • [Cites] J Urol. 1995 Apr;153(4):1220-1 [7869505.001]
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  • (PMID = 17160444.001).
  • [ISSN] 0301-1623
  • [Journal-full-title] International urology and nephrology
  • [ISO-abbreviation] Int Urol Nephrol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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58. Hafner C, Schmiemann V, Ruetten A, Coras B, Landthaler M, Reifenberger J, Vogt T: PTCH mutations are not mainly involved in the pathogenesis of sporadic trichoblastomas. Hum Pathol; 2007 Oct;38(10):1496-500
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Trichoblastomas are rare, benign tumors of the appendix in human skin.
  • The histopathology comprises elements of basal cell carcinoma and trichoepithelioma with a variable degree of follicular differentiation.
  • Both basal cell carcinoma and trichoepithelioma reveal alterations of PTCH, the human homolog of the Drosophila segment polarity patched gene.
  • The Pro/Leu polymorphism in germline is associated with a higher risk for breast cancer, but a potential contribution to the tumorigenesis of trichoblastoma is unknown.
  • [MeSH-major] Appendiceal Neoplasms / genetics. Appendiceal Neoplasms / pathology. Carcinoma, Basal Cell / genetics. Receptors, Cell Surface / genetics

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  • (PMID = 17597182.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Cell Surface; 0 / patched receptors
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59. Young RH: The history of British gynaecological pathology. Histopathology; 2009 Jan;54(2):144-55
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  • Doran wrote an early study of tubal carcinoma and a book on that organ and the ovary.
  • She co-authored a monumental book on the appendix, likely never to be equalled.

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  • (PMID = 19207941.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Historical Article; Journal Article; Portraits; Review
  • [Publication-country] England
  • [Number-of-references] 59
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60. Suzuki J, Kazama S, Kitayama J, Uozaki H, Miyata T, Nagawa H: Signet ring cell carcinoma of the appendix manifesting as colonic obstruction and ovarian tumors: report of a case. Surg Today; 2009;39(3):235-40
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  • [Title] Signet ring cell carcinoma of the appendix manifesting as colonic obstruction and ovarian tumors: report of a case.
  • Appendiceal cancer is rare and associated with a poor prognosis because it is usually found at an advanced stage.
  • We performed ileocecal resection, colectomy, and oophorectomy, following which a histological diagnosis of signet ring cell carcinoma was made.
  • Immunohistochemical analysis revealed positive expression of cytokeratin 7 and 20, and mucin core protein 2 (MUC2), compatible with appendiceal cancer and Kruckenberg metastases.
  • When a patient is found to have disseminated pelvic signet ring cell carcinoma of unknown origin, the appendix should be considered as a possible primary site.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Carcinoma, Signet Ring Cell / pathology. Intestinal Obstruction / etiology. Ovarian Neoplasms / pathology
  • [MeSH-minor] Aged. Biomarkers / analysis. Female. Humans. Magnetic Resonance Imaging. Peritoneal Neoplasms / diagnosis. Peritoneal Neoplasms / secondary. Peritoneal Neoplasms / surgery. Tomography, X-Ray Computed


61. Haeri S, Cosin JA: Endometriosis mimicking ovarian cancer in the setting of acquired immune deficiency syndrome. Obstet Gynecol; 2009 Aug;114(2 Pt 2):425-6
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  • [Title] Endometriosis mimicking ovarian cancer in the setting of acquired immune deficiency syndrome.
  • CASE: A woman with AIDS and 2-month history of abdominal pain, distention, and weight loss was found to have periumbilical and pelvic masses, ascites, lymphadenopathy, and an elevated CA 125 level.
  • Operative findings included chocolate-colored ascites and peritoneal seeding involving the ovaries, uterus, appendix, bowel, umbilicus, and omentum.
  • Pathologic diagnosis was endometriosis and AIDS-associated adenopathy.
  • [MeSH-major] Acquired Immunodeficiency Syndrome / complications. Carcinoma / diagnosis. Endometriosis / diagnosis. Endometriosis / virology. Ovarian Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans


62. Kim HC, Yang DM, Jin W, Kim GY, Choi SI: Metastasis to the appendix from a hepatocellular carcinoma manifesting as acute appendicitis: CT findings. Br J Radiol; 2008 Jul;81(967):e194-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastasis to the appendix from a hepatocellular carcinoma manifesting as acute appendicitis: CT findings.
  • Metastasis to the appendix is extremely rare.
  • Moreover, metastasis from a hepatocellular carcinoma (HCC) has not been reported in the English language literature.
  • We report a case of metastasis to the appendix from a HCC in a 50-year-old man who presented with pain in the right lower quadrant of the abdomen, representing acute appendicitis.
  • On CT, a hypervascular mass occupying the lumen of the appendix with distension of the appendiceal tip and surrounding peritoneal seeding of the HCC were observed.
  • This is the first report of CT findings of metastasis to the appendix from a HCC.
  • [MeSH-major] Appendiceal Neoplasms / secondary. Appendicitis / etiology. Carcinoma, Hepatocellular / secondary. Liver Neoplasms

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  • (PMID = 18559899.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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63. Wakahara T, Yamamoto S, Fujita S, Akasu T, Onouchi S, Moriya Y: A case of advanced rectal adenocarcinoid tumor with long-term survival. Jpn J Clin Oncol; 2010 Jul;40(7):690-3
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  • Adenocarcinoid tumor most commonly occurs in the appendix and a tumor arising in the rectum is extremely rare.
  • Microscopically and immunohistochemically, the tumor consisted of carcinoid-like components and signet-ring-cell-carcinoma-like components, and an adenocarcinoid tumor was diagnosed.
  • [MeSH-major] Adenocarcinoma / diagnosis. Rectal Neoplasms / diagnosis

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  • (PMID = 20338947.001).
  • [ISSN] 1465-3621
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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64. Piura B, Rabinovich A, Shaco-Levy R: Squamous cell carcinoma arising in ovarian mature cystic teratoma with isolated metastasis to the appendix. J Obstet Gynaecol; 2009 Jan;29(1):71-3
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  • [Title] Squamous cell carcinoma arising in ovarian mature cystic teratoma with isolated metastasis to the appendix.
  • [MeSH-major] Appendiceal Neoplasms / secondary. Carcinoma, Squamous Cell / secondary. Neoplasms, Multiple Primary / pathology. Ovarian Neoplasms / pathology. Teratoma / pathology

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  • (PMID = 19280511.001).
  • [ISSN] 1364-6893
  • [Journal-full-title] Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology
  • [ISO-abbreviation] J Obstet Gynaecol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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65. Schrofer C, Villiger P, Cathomas R: [Multiple primary neoplasms - coincidence or tumor syndrom?]. Praxis (Bern 1994); 2009 Sep 9;98(18):1027-31
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  • BACKGROUND: Multiple primary neoplasms occur either by hazard or in the context of hereditary cancer syndromes, after chronic toxic exposition, in immunodeficiency or as secondary malignancies after radio- and/or chemotherapy.
  • CASE REPORT: We present the history of an actually asymptomatic female patient with four different malignancies within 30 years: malignant melanoma (1976), liposarcoma (1983), carcinoma of the appendix (2006) and lymphoma (2006).
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Appendiceal Neoplasms / diagnosis. Ileal Neoplasms / diagnosis. Liposarcoma / diagnosis. Lymphoma, Follicular / diagnosis. Melanoma / diagnosis. Neoplasms, Second Primary / diagnosis. Skin Neoplasms / diagnosis. Soft Tissue Neoplasms / diagnosis

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  • (PMID = 19739050.001).
  • [ISSN] 1661-8157
  • [Journal-full-title] Praxis
  • [ISO-abbreviation] Praxis (Bern 1994)
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Switzerland
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66. Hristov AC, Young RH, Vang R, Yemelyanova AV, Seidman JD, Ronnett BM: Ovarian metastases of appendiceal tumors with goblet cell carcinoidlike and signet ring cell patterns: a report of 30 cases. Am J Surg Pathol; 2007 Oct;31(10):1502-11
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  • In cases in which the primary tumor is not already evident, their "goblet cell carcinoidlike" patterns should direct attention to the appendix as a possible source.
  • [MeSH-major] Adenocarcinoma / secondary. Appendiceal Neoplasms / pathology. Carcinoid Tumor / secondary. Carcinoma, Signet Ring Cell / secondary. Ovarian Neoplasms / secondary

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  • (PMID = 17895750.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chromogranins; 0 / Synaptophysin
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67. McGory ML, Maggard MA, Kang H, O'Connell JB, Ko CY: Malignancies of the appendix: beyond case series reports. Dis Colon Rectum; 2005 Dec;48(12):2264-71
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  • [Title] Malignancies of the appendix: beyond case series reports.
  • This characterization provides a novel description of the presentation and outcomes for malignancies of the appendix and highlights that a substantial number of patients with appendiceal tumors may not be receiving appropriate surgical resection.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Appendiceal Neoplasms / pathology. Carcinoid Tumor / pathology. Carcinoma, Signet Ring Cell / pathology

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  • (PMID = 16258711.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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68. Molavi D, Argani P: Distinguishing benign dissecting mucin (stromal mucin pools) from invasive mucinous carcinoma. Adv Anat Pathol; 2008 Jan;15(1):1-17
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  • [Title] Distinguishing benign dissecting mucin (stromal mucin pools) from invasive mucinous carcinoma.
  • Mucin dissecting stroma suggests the presence of an invasive mucinous (colloid) carcinoma.
  • However, in virtually every organ in which invasive mucinous carcinoma exists, there exist benign mimickers associated with dissecting mucin.
  • This article reviews diagnostic criteria for the differential diagnosis of mucinous lesions of the breast, pancreas, biliary tract, colon, appendix, and bladder, emphasizing practical points, which we find helpful in daily diagnostic surgical pathology practice.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Adenocarcinoma, Mucinous / pathology. Epithelial Cells / pathology. Mucins
  • [MeSH-minor] Breast Neoplasms / diagnosis. Breast Neoplasms / pathology. Colonic Neoplasms / diagnosis. Colonic Neoplasms / pathology. Diagnosis, Differential. Female. Humans. Male. Pancreatic Neoplasms / diagnosis. Pancreatic Neoplasms / pathology

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  • (PMID = 18156808.001).
  • [ISSN] 1072-4109
  • [Journal-full-title] Advances in anatomic pathology
  • [ISO-abbreviation] Adv Anat Pathol
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA 88843
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Mucins
  • [Number-of-references] 51
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69. Tran TA, Holloway RW, Finkler NJ: Metastatic appendiceal mucinous adenocarcinoma to well-differentiated diffuse mesothelioma of the peritoneal cavity: a mimicker of florid mesothelial hyperplasia in association with neoplasms. Int J Gynecol Pathol; 2008 Oct;27(4):526-30
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  • In those instances, the mesothelial proliferation might create a misdiagnosis of metastatic carcinoma but seldom raises the possibility of a well-differentiated mesothelioma seeded by metastatic neoplastic cells.
  • The subsequent operation, however, demonstrated a mucinous neoplasm of the appendix with involvement of the peritoneal cavity in the form of peritoneal mucinous carcinomatosis as well as metastases to the uterine serosa and adnexal surfaces.
  • Although commonly associated with atypical/ florid mesothelial hyperplasia, a carcinoma can rarely metastasize to a well-differentiated mesothelioma, which can pose significant diagnostic difficulties because it can mimic a reactive process.
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Histocytochemistry. Humans

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  • (PMID = 18753969.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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70. Smejkal P, Pazdro A, Smejkal M, Pafko P, Frantlová M: [The cystadenocarcinoma of the appendix]. Rozhl Chir; 2005 Jan;84(1):33-6
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  • [Title] [The cystadenocarcinoma of the appendix].
  • [Transliterated title] Kystadenokarcinom apendixu.
  • Histology confirmed a mucous cystadenocarcinoma of the appendix.
  • Furthermore, the authors discuss this fairly rare type of the GIT carcinoma.

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  • (PMID = 15813454.001).
  • [ISSN] 0035-9351
  • [Journal-full-title] Rozhledy v chirurgii : měsíčník Československé chirurgické společnosti
  • [ISO-abbreviation] Rozhl Chir
  • [Language] cze
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Czech Republic
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71. Acs G: Serous and mucinous borderline (low malignant potential) tumors of the ovary. Am J Clin Pathol; 2005 Jun;123 Suppl:S13-57
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  • Molecular data suggest that such tumors may represent an intermediate stage in the typical SBOT-invasive low-grade serous carcinoma progression.
  • Mucinous tumors associated with pseudomyxoma peritonei are almost always secondary to similar tumors of the appendix or other gastrointestinal sites and should not be diagnosed as high-stage I-MBOTs.
  • [MeSH-major] Cystadenocarcinoma, Mucinous / classification. Cystadenocarcinoma, Mucinous / diagnosis. Cystadenocarcinoma, Serous / classification. Cystadenocarcinoma, Serous / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Ovarian Neoplasms

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  • (PMID = 16100867.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 296
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72. Iarŭmov N, Terziev I, Toshev S, Angelov K, Velev G, Todorov G, Koĭchev A, Ilinov V: [Pseudomyxoma peritonei--a case report]. Khirurgiia (Sofiia); 2006;(3):15-9
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  • Pseudomyxoma peritonei is a rare condition consisting of mucinous ascites, most commonly arising from mucinous tumors of the appendix and occasionally from the ovary.
  • Ronnett et al. have suggested a classification based on tumor pathology where they place all pseudomyxoma peritonei in three groups in order of decreasing prognosis: disseminated peritoneal adenomucinosis (DPAM), peritoneal mucinous carcinoma with intermediate or discordant features (PMCA) and peritoneal mucinous carcinoma (PMCA).
  • [MeSH-minor] Aged. Diagnosis, Differential. Digestive System Surgical Procedures. Disease-Free Survival. Female. Humans. Male. Middle Aged

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  • (PMID = 18788112.001).
  • [ISSN] 0450-2167
  • [Journal-full-title] Khirurgii︠a︡
  • [ISO-abbreviation] Khirurgiia (Sofiia)
  • [Language] bul
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Bulgaria
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73. Samet I, Cormier B, Mowlawi H, Philippe A, Arbion F, Fétissof F: [Endometrial and endocervical lesions associated with pseudomyxoma peritonei: a case report]. Ann Pathol; 2009 Jun;29(3):233-7
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  • The association of a pseudomyxoma peritonei with a mucinous tumor of the appendix and/or the ovary is regularly reported in the literature.
  • We report the case of a 57-year-old patient, with pseudomyxoma peritonei associated with a low-grade mucinous neoplasia of appendix and both ovaries.
  • Histological and immunohistochemical characteristics of this epithelium were quite comparable to those observed in the appendix and ovaries.
  • The endocervical and endometrial lesions might represent an implantation of mucinous epithelium from appendix, emphasizing the capacity of this epithelium to implant at a distance from the original lesion.
  • [MeSH-minor] Appendectomy. Breast Neoplasms / diagnosis. Carcinoma, Ductal, Breast / diagnosis. Epithelial Cells / pathology. Female. Humans. Hysterectomy. Metaplasia. Middle Aged. Neoplasm Invasiveness. Ovariectomy


74. Ayhan A, Gultekin M, Sağlam EA, Dursun P, Dogan NU, Aksan G, Usubutun A, Yuce K: Depth of invasion for appendiceal metastasis of ovarian cancers: does it have any clinical significance? J Obstet Gynaecol Res; 2008 Aug;34(4):557-60
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  • AIM: Depth of appendiceal metastasis in patients with epithelial ovarian carcinoma (EOC) has not been previously analyzed for a possible relationship with clinico-pathological variables.
  • Appendiceal metastases were defined as serosal (if tumoral spread involved only serosa of the appendix) or sero-mucosal (if tumoral spread also involved either muscular or mucosal surfaces of the appendix).
  • RESULTS: Thirty-nine patients had serosal appendiceal metastasis (56.5%), while the remaining 30 patients (43.5%) had appendiceal metastasis extending toward the muscular layer (seromucosal metastasis: 16 within muscularis mucosa, 14 within the mucosa of the appendix).
  • The mean age at the time of diagnosis was 54.58 years (range, 26-88 years), with no significant difference between the groups (P = 0.9).
  • CONCLUSION: This is the first report to analyze the metastatic pattern of EOC on the appendix with respect to depth of invasion which could not reveal a significant difference.

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  • (PMID = 18937709.001).
  • [ISSN] 1341-8076
  • [Journal-full-title] The journal of obstetrics and gynaecology research
  • [ISO-abbreviation] J. Obstet. Gynaecol. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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75. Bucher P, Gervaz P, Ris F, Oulhaci W, Egger JF, Morel P: Surgical treatment of appendiceal adenocarcinoid (goblet cell carcinoid). World J Surg; 2005 Nov;29(11):1436-9
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  • Adenocarcinoid of the appendix is an infrequent tumor with histologic features of both adenocarcinoma and carcinoid tumor.
  • One patient subsequently died of colon carcinoma 6 years after adenocarcinoid treatment.
  • (2) does not extend beyond the appendix adventitia;.

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  • (PMID = 16136284.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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76. Fotopoulou C, Schumacher G, Schefold JC, Denkert C, Lichtenegger W, Sehouli J: Systematic evaluation of the intraoperative tumor pattern in patients with borderline tumor of the ovary. Int J Gynecol Cancer; 2009 Dec;19(9):1550-5
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  • We conducted a systematic evaluation of the macroscopic and microscopic tumor spreads in patients with BOTs with special focus on the diagnosis of invasive and noninvasive lesions.
  • METHODS: Between January 2001 and July 2008, data of patients with BOTs were evaluated using a systematic and validated documentation tool (intraoperative mapping of ovarian cancer).
  • Sixteen patients (31.37%) presented extraovarian involvement into the peritoneum (23.5%), omentum (17.7%), uterus (7.84%), sigmoid (7.8%), lymph nodes (7.8%), ileum (3.9%), mesentery (5.9%), and appendix (1.96%).
  • [MeSH-major] Carcinoma / diagnosis. Carcinoma / surgery. Neoplasm Staging / methods. Ovarian Neoplasms / diagnosis. Ovarian Neoplasms / surgery

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  • (PMID = 19955936.001).
  • [ISSN] 1525-1438
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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77. Rindi G, Inzani F, Solcia E: Pathology of gastrointestinal disorders. Endocrinol Metab Clin North Am; 2010 Dec;39(4):713-27
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  • Most gastric neuroendocrine tumors (NETs) are silent and composed by ECL cells, the second most frequent neuroendocrine neoplasms being the high-grade neuroendocrine carcinoma (NEC).
  • No systematic definition of nonneoplastic lesions exists for endocrine cells of the ileum, appendix, and colon-rectum.

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 21095540.001).
  • [ISSN] 1558-4410
  • [Journal-full-title] Endocrinology and metabolism clinics of North America
  • [ISO-abbreviation] Endocrinol. Metab. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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78. Wejman J, Bielecki K, Ostrowska J, Baczuk L, Perkowska-Ptasińska A, Tarnowski W: Pathological analysis of lesions within intestines resected due to ulcerative colitis. Pol J Pathol; 2006;57(2):113-6
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  • There were 3 cases, in which histological assessment revealed the presence of malignancy (2 cases of mucus producing adenocarcinoma and one case of carcinoma in situ situated in the anal canal).
  • [MeSH-major] Appendix / pathology. Colitis, Ulcerative / pathology. Colon / pathology

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  • (PMID = 17019974.001).
  • [ISSN] 1233-9687
  • [Journal-full-title] Polish journal of pathology : official journal of the Polish Society of Pathologists
  • [ISO-abbreviation] Pol J Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Poland
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79. Subramanya D, Grivas PD, Styler M: Appendiceal carcinoma: a diagnostic and therapeutic challenge. Postgrad Med; 2008 Nov;120(4):95-100
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  • [Title] Appendiceal carcinoma: a diagnostic and therapeutic challenge.
  • Appendiceal carcinoma is a very rare clinical entity, constituting 1% of all colorectal malignancies and 1% of all appendectomy specimens.
  • We present a patient with mucinous carcinoma of the appendix who presented with hematuria and abdominal pain.
  • Similar case reports are extremely rare in the literature, while typical presentations of appendiceal carcinoma include abdominal pain, abdominal mass, early satiety, nausea, and iron-deficiency anemia.
  • Initially, the diagnostic investigation in our patient was focused on urinary tract disorders, but ultimately resulted in finding a mucinous appendiceal carcinoma.
  • The carcinoma had invaded the urinary bladder and was disseminated in the peritoneal cavity.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Adenocarcinoma, Mucinous / surgery. Appendiceal Neoplasms / diagnosis. Appendiceal Neoplasms / surgery

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  • (PMID = 19020371.001).
  • [ISSN] 1941-9260
  • [Journal-full-title] Postgraduate medicine
  • [ISO-abbreviation] Postgrad Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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80. Pahlavan PS, Kanthan R: Goblet cell carcinoid of the appendix. World J Surg Oncol; 2005 Jun 20;3:36
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  • [Title] Goblet cell carcinoid of the appendix.
  • BACKGROUND: Goblet cell carcinoid (GCC) of the appendix is a rare neoplasm that share histological features of both adenocarcinoma and carcinoid tumor.
  • This review summarizes the published literature on GCC of the appendix.
  • The focus is on its diagnosis, histopathological aspects, clinical manifestations, and management.
  • METHODS: Published studies in the English language between 1966 to 2004 were identified through Medline keyword search utilizing terms "goblet cell carcinoid," "adenocarcinoid", "mucinous carcinoid" and "crypt cell carcinoma" of the appendix.
  • RESULTS: Based on the review of 57 published papers encompassing nearly 600 diagnosed patients, the mean age of presentation for GCC of the appendix was 58.89 years with equal representation in both males and females.
  • Accurate diagnosis of this neoplasm requires astute observations within an acutely inflamed appendix as this neoplasm has a prominent pattern of submucosal growth and usually lacks the formation of a well-defined tumor mass.
  • Concomitant distant metastasis at diagnosis was present in 11.16% of patients with the ovaries being the most common site in 3.60% followed by disseminated abdominal carcinomatosis in 1.03%.
  • Local lymph node involvement was seen in 8.76% of patients at the time of diagnosis.
  • GCC's of the appendix remains a neoplasm of unpredictable biological behavior and thus warrants lifelong surveillance for recurrence of the disease upon diagnosis and successful surgical extirpation.
  • CONCLUSION: GCC of the appendix is a rare neoplasm.
  • Due to its wide range of presentation, this tumor should be considered as a possible diagnosis in many varied situations leading to abdominal surgery.
  • In female patients with GCC of the appendix regardless of age, bilateral salpingo-oophorectomy is advocated.

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  • (PMID = 15967038.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1182398
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81. Couvelard A: [Appendicular pathology. Mixed endocrine carcinoma with poorly differentiated large cell component]. Ann Pathol; 2010 Apr;30(2):124-9
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  • [Title] [Appendicular pathology. Mixed endocrine carcinoma with poorly differentiated large cell component].
  • [Transliterated title] Pathologie de l'appendice. Cas no 7. Carcinome endocrine mixte avec contingent peu différencié à grandes cellules.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Appendicitis / etiology. Appendix / pathology. Carcinoma, Large Cell / pathology. Carcinoma, Neuroendocrine / pathology

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  • (PMID = 20451071.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Antigens, CD56; 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / Neoplasm Proteins; 0 / Synaptophysin; 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53
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82. Varona JF, Guerra JM, Salamanca J, Colina F, Lopez G, Morales M: Pseudomyxoma peritonei: a clinicopathologic analysis and follow-up of 21 patients. Hepatogastroenterology; 2005 May-Jun;52(63):812-6
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  • The most frequent primary site of origin of the pseudomyxoma was the appendix (10 cases).
  • The histologic diagnosis was malignant (associated with carcinoma) in 17 cases and indeterminate behavior in 4.
  • The appendix is the most frequent primary site of origin of pseudomyxoma peritonei, followed by bowel; the latter being more important than previously described.

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  • (PMID = 15966210.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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83. Cotton F, Pellet O, Gilly FN, Granier A, Sournac L, Glehen O: MRI evaluation of bulky tumor masses in the mesentery and bladder involvement in peritoneal carcinomatosis. Eur J Surg Oncol; 2006 Dec;32(10):1212-6
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  • METHODS: Three experts retrospectively reviewed abdominal and pelvic MRI from 19 cases of surgically proved PC (ovary: 7; colorectal: 7; gastric: 2; pseudomyxoma peritonei: 2; appendix: 1).
  • [MeSH-major] Carcinoma / diagnosis. Carcinoma / secondary. Magnetic Resonance Imaging. Mesentery / pathology. Peritoneal Neoplasms / diagnosis. Peritoneal Neoplasms / secondary. Urinary Bladder Neoplasms / diagnosis. Urinary Bladder Neoplasms / secondary
  • [MeSH-minor] Contrast Media. Gadolinium. Humans. Intestinal Neoplasms / diagnosis. Intestinal Neoplasms / secondary. Intestinal Neoplasms / surgery. Intestines / pathology. Meglumine / analogs & derivatives. Organometallic Compounds. Urinary Bladder / pathology

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  • (PMID = 16762527.001).
  • [ISSN] 0748-7983
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Organometallic Compounds; 15G12L5X8K / gadobenic acid; 6HG8UB2MUY / Meglumine; AU0V1LM3JT / Gadolinium
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84. Umemoto M, Shiota M, Shimaoka M, Hoshiai H: Definitive diagnosis of primary adenocarcinoma of the appendix by laparoscopic appendectomy. J Obstet Gynaecol Res; 2007 Aug;33(4):590-4
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  • [Title] Definitive diagnosis of primary adenocarcinoma of the appendix by laparoscopic appendectomy.
  • We report a 62-year-old woman with a primary adenocarcinoma of the appendix mimicking ovarian tumor.
  • However, the present case suggests that, in some cases, if cancer of the appendix can be diagnosed early, laparotomy can be avoided and the cancer treated with minimally invasive laparoscopic surgery alone.

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  • (PMID = 17688638.001).
  • [ISSN] 1341-8076
  • [Journal-full-title] The journal of obstetrics and gynaecology research
  • [ISO-abbreviation] J. Obstet. Gynaecol. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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85. Rindi G, Klöppel G, Couvelard A, Komminoth P, Körner M, Lopes JM, McNicol AM, Nilsson O, Perren A, Scarpa A, Scoazec JY, Wiedenmann B: TNM staging of midgut and hindgut (neuro) endocrine tumors: a consensus proposal including a grading system. Virchows Arch; 2007 Oct;451(4):757-62
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  • The proposed tumor-node-metastasis (TNM) classifications are based on the recently published ENETS Guidelines for the Diagnosis and Treatment of gastroenteropancreatic NETs and follow our previous proposal for foregut tumors.
  • The new TNM classifications for NETs of the ileum, appendix, colon, and rectum, and the grading system were designed, discussed, and consensually approved by all conference participants.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Carcinoma, Neuroendocrine / pathology. Colonic Neoplasms / pathology. Ileal Neoplasms / pathology. Neoplasm Staging / methods. Rectal Neoplasms / pathology

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  • (PMID = 17674042.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Consensus Development Conference; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Number-of-references] 37
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86. Kabiri H, Clarke LE, Tzarnas CD: Appendiceal diverticulitis. Am Surg; 2006 Mar;72(3):221-3
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  • Patients often seek medical treatment much later than those with classic appendicitis, and if there is a delay in establishing the correct diagnosis, perforation within the mesentery is found at the time of operation.
  • Also, it is often mistakenly identified as carcinoma and it has higher rate of perforation and a longer convaslescence.
  • [MeSH-major] Appendix / pathology. Cecal Diseases / diagnosis. Diverticulitis / diagnosis
  • [MeSH-minor] Adult. Appendectomy. Diagnosis, Differential. Follow-Up Studies. Humans. Male. Tomography, X-Ray Computed


87. Deschamps L, Couvelard A: Endocrine tumors of the appendix: a pathologic review. Arch Pathol Lab Med; 2010 Jun;134(6):871-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Endocrine tumors of the appendix: a pathologic review.
  • CONTEXT: Although rare, appendiceal endocrine tumors are the most common neoplasms of the appendix.
  • OBJECTIVE: To provide recent data that focus on the pathology of endocrine tumors of the appendix including classifications and guidelines for patient management.
  • Most patients with classic endocrine tumors of the appendix have a favorable prognosis.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Carcinoma, Neuroendocrine / pathology
  • [MeSH-minor] Appendectomy. Carcinoid Tumor / classification. Carcinoid Tumor / diagnosis. Carcinoid Tumor / pathology. Colectomy. Humans. Prognosis. World Health Organization

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  • (PMID = 20524865.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 41
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88. Romaní J, Yébenes M: [Repair of surgical defects of the nasal pyramid]. Actas Dermosifiliogr; 2007 Jun;98(5):302-11
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  • [Transliterated title] Resolución de los defectos quirúrgicos de la pirámide nasal.
  • Basal cell and squamous cell carcinoma frequently affect the nasal appendix and its adjacent structures.

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  • (PMID = 17555672.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 14
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89. Iwuagwu OC, Jameel JK, Drew PJ, Hartley JE, Monson JR: Primary carcinoma of the appendix - Hull series. Dig Surg; 2005;22(3):163-7
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  • [Title] Primary carcinoma of the appendix - Hull series.
  • BACKGROUND: Appendiceal carcinoma (AC) is a rare entity that does not have a well-defined treatment strategy.
  • At presentation, most patients are clinically thought to have appendicitis and the diagnosis is made only by formal histology.
  • Once the diagnosis of AC is made, patients are treated by various strategies including surgery, chemotherapy depending on nodal status of the disease.
  • Five patients survived at least 4 years from the time of diagnosis.

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  • [Copyright] Copyright (c) 2005 S. Karger AG, Basel.
  • (PMID = 16037676.001).
  • [ISSN] 0253-4886
  • [Journal-full-title] Digestive surgery
  • [ISO-abbreviation] Dig Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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90. Green S, Tawil A, Barr H, Bennett C, Bhandari P, Decaestecker J, Ragunath K, Singh R, Jankowski J: Surgery versus radical endotherapies for early cancer and high grade dysplasia in Barrett's oesophagus. Cochrane Database Syst Rev; 2009;(2):CD007334
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  • [Title] Surgery versus radical endotherapies for early cancer and high grade dysplasia in Barrett's oesophagus.
  • Currently the mainstay of therapy is surgical management of advanced cancer but this has improved the five-year survival very little in the last 30 years.
  • OBJECTIVES: We used data from randomised controlled trials to examine the effectiveness of endotherapies compared with surgery, in people with Barrett's Oesophagus; those with early neoplasias (defined as high grade dysplasia (HGD), and those with early cancer (defined as carcinoma in-situ, superficially invasive, early cancer or superficial cancer T-1m (T1-a) and T-1sm (T1-b)).
  • SELECTION CRITERIA: Types of studies: randomised controlled trials comparing endotherapies with surgery in the treatment of high grade dysplasia (HGD), or early cancer.
  • All cellular types of cancer were included (i.e. adenocarcinomas, squamous cell carcinomas and more unusual types) but will be discussed separately.
  • TYPES OF PARTICIPANTS: patients of any age and either gender with a histologically confirmed diagnosis of early neoplasia (HGD and early cancer) in Barrett's or squamous lined oesophagus.Types of interventions; endotherapies (the intervention) compared with surgery (the control), all with curative intent.
  • DATA COLLECTION AND ANALYSIS: Reports of studies which meet the inclusion criteria for this review would have been analysed using the methods detailed in Appendix 9.

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  • [UpdateIn] Cochrane Database Syst Rev. 2010;(5):CD007334 [20464752.001]
  • (PMID = 19370683.001).
  • [ISSN] 1469-493X
  • [Journal-full-title] The Cochrane database of systematic reviews
  • [ISO-abbreviation] Cochrane Database Syst Rev
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 85
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91. Yamaguchi H, Ishimaru M, Suzuki H, Yamashita H, Hatanaka K, Uekusa T, Nagawa H: Isolated abdominal wound recurrence after lymph-node dissection for appendiceal adenocarcinoma. Am J Surg; 2010 Jan;199(1):e7-9
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  • Postoperative histology revealed a moderately differentiated adenocarcinoma in the appendix that invaded the submucosa along with lymphatic involvement.
  • The mechanism of abdominal wound recurrence is considered the leakage of carcinoma cells from transected lymph vessels during lymph node dissection, followed by the implantation of these cells into the abdominal wound.
  • [MeSH-minor] Abdominal Pain / diagnosis. Abdominal Pain / etiology. Appendectomy / methods. Cicatrix / pathology. Follow-Up Studies. Humans. Immunohistochemistry. Lymph Node Excision / methods. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. Reoperation. Risk Assessment. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 19837396.001).
  • [ISSN] 1879-1883
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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92. Bruin SC, Verwaal VJ, Vincent A, van't Veer LJ, van Velthuysen ML: A clinicopathologic analysis of peritoneal metastases of colorectal and appendiceal origin. Ann Surg Oncol; 2010 Sep;17(9):2330-40
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  • RESULTS: PM could be categorized into four groups: low-grade, well-differentiated mucinous tumor (DPAM); intermediated-grade mucinous carcinoma (PMCA-i); high-grade mucinous carcinoma (PMCA); and high-grade nonmucinous carcinoma (PCA).
  • Of PM originating from an appendix tumor, 29% were of non-DPAM type.

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  • (PMID = 20232161.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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93. van Huisseling H, van Hanegem L, van Dijk M: Post-menopausal vaginal bleeding caused by carcinoma of the appendix: a case report. J Med Case Rep; 2010;4:127
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  • [Title] Post-menopausal vaginal bleeding caused by carcinoma of the appendix: a case report.
  • The most frequent malignancy found in cases of post-menopausal bleeding is endometrial cancer.
  • To the best of our knowledge, it appears that this is the first published case of a post-menopausal primary appendiceal carcinoma presenting with vaginal blood loss.
  • After extensive examination and discussion, ovarian carcinoma was suggested.
  • Microscopic examination of the tissue removed at laparotomy revealed an adenocarcinoma of the appendix.

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  • (PMID = 20433768.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2873455
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94. Ramirez PT, Slomovitz BM, McQuinn L, Levenback C, Coleman RL: Role of appendectomy at the time of primary surgery in patients with early-stage ovarian cancer. Gynecol Oncol; 2006 Dec;103(3):888-90
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  • [Title] Role of appendectomy at the time of primary surgery in patients with early-stage ovarian cancer.
  • OBJECTIVE: To determine whether appendectomy is warranted in patients with apparent early-stage ovarian cancer who undergo surgery for staging and cytoreduction and to determine the complication rate associated with appendectomy in such patients.
  • METHODS: We reviewed the medical records of all patients who underwent appendectomy at the time of primary surgery for ovarian cancer at The University of Texas M. D.
  • Anderson Cancer Center between January 1992 and December 2004 and who did not meet any of the following exclusion criteria: stage III or IV ovarian cancer, appendectomy as part of a second-look procedure or secondary tumor-reductive surgery, primary appendiceal cancer, primary gastrointestinal malignancy with metastasis to the appendix, incomplete clinicopathologic data, appendicitis as a preoperative diagnosis, primary fallopian tube cancer, primary peritoneal cancer, or documented dual primary tumors.
  • Histologic diagnoses were as follows: invasive epithelial carcinoma, 35 patients (61%); tumor of low malignant potential, 15 patients (26%); malignant germ cell tumor, 4 patients (7%); and other, 3 patients (5%).
  • The median CA-125 level was 36.2 U/mL (range, 7-7900).
  • CONCLUSIONS: Appendectomy at the time of surgery for apparent early-stage ovarian cancer is not associated with complications but should not be routinely recommended.
  • [MeSH-major] Appendectomy / utilization. Appendix / surgery. Ovarian Neoplasms / surgery

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  • (PMID = 16806436.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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95. Piso P, Dahlke MH, Ghali N, Iesalnieks I, Loss M, Popp F, von Breitenbuch P, Agha A, Lang SA, Kullmann F, Schlitt HJ: Multimodality treatment of peritoneal carcinomatosis from colorectal cancer: first results of a new German centre for peritoneal surface malignancies. Int J Colorectal Dis; 2007 Nov;22(11):1295-300
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  • [Title] Multimodality treatment of peritoneal carcinomatosis from colorectal cancer: first results of a new German centre for peritoneal surface malignancies.
  • BACKGROUND: The presence of peritoneal carcinomatosis arising from colorectal cancer is associated with a poor prognosis.
  • All had a primary colorectal carcinoma.
  • RESULTS: Of all patients, 16 had appendix and 16 non-appendiceal colorectal carcinoma.

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  • (PMID = 17458551.001).
  • [ISSN] 0179-1958
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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96. Lim C, Tordjmann D, Gornet JM, Nemeth J, Valleur P, Pocard M: [Prospective study of quality of life after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy using oxaliplatin for peritoneal carcinomatosis]. Bull Cancer; 2010 Sep;97(9):1053-60
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  • [Transliterated title] Étude prospective de la qualité de vie après une CHIP par oxaliplatine pour carcinose péritonéale.
  • PC originated in primary lesions of the colon/rectum (N = 17), ovary (N = 3), stomach (N = 3), appendix (N = 2), mesothelium (N = 2), pseudomyxoma peritonei (N = 3) and primary carcinoma of peritoneum (N = 2).
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Carcinoma. Hyperthermia, Induced / methods. Organoplatinum Compounds / therapeutic use. Peritoneal Neoplasms. Quality of Life

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  • (PMID = 20693116.001).
  • [ISSN] 1769-6917
  • [Journal-full-title] Bulletin du cancer
  • [ISO-abbreviation] Bull Cancer
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Organoplatinum Compounds; 04ZR38536J / oxaliplatin
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97. Glazer ES, Massey KL, Curley SA: A protocol to effectively create single cell suspensions of adherent cells for multiparameter high-throughput flow cytometry. In Vitro Cell Dev Biol Anim; 2010 Feb;46(2):97-101
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  • Doxorubicin, a cytotoxic agent, was administered to adherent human pancreatic carcinoma cell lines (Panc-1 and AsPC-1) to produce alterations in the cell cycle and intracellular protein expression.

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  • (PMID = 19997869.001).
  • [ISSN] 1543-706X
  • [Journal-full-title] In vitro cellular & developmental biology. Animal
  • [ISO-abbreviation] In Vitro Cell. Dev. Biol. Anim.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / 5 T32 CA09599; United States / NCI NIH HHS / CA / CA16672
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Cell Adhesion Molecules; 80168379AG / Doxorubicin; EC 3.4.21.4 / Trypsin; EC 3.4.24.- / Collagenases
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98. Rohani P, Scotti SD, Shen P, Stewart JH, Russell GB, Cromer M, Levine EA: Use of FDG-PET imaging for patients with disseminated cancer of the appendix. Am Surg; 2010 Dec;76(12):1338-44
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  • [Title] Use of FDG-PET imaging for patients with disseminated cancer of the appendix.
  • The goal of this study is to evaluate the use of positron emission tomography (PET) in evaluation of patients with peritoneal dissemination of carcinoma of appendiceal origin (PDA).
  • We do not recommend the use of FDG-PET for patients with PDA from cancer of the appendix.

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  • (PMID = 21265346.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / K08 CA131482
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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99. Lee SH, Chaung CR: Mucinous metaplasia of breast carcinoma with macrocystic transformation resembling ovarian mucinous cystadenocarcinoma in a case of synchronous bilateral infiltrating ductal carcinoma. Pathol Int; 2008 Sep;58(9):601-5
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  • [Title] Mucinous metaplasia of breast carcinoma with macrocystic transformation resembling ovarian mucinous cystadenocarcinoma in a case of synchronous bilateral infiltrating ductal carcinoma.
  • Mammary mucinous cystadenocarcinoma (MCA) is a rare, invasive ductal carcinoma (IDC) of the breast that is virtually identical morphologically to MCA of the ovary, pancreas or appendix.
  • Synchronous bilateral breast tumors, not uncommonly encountered in fibroadenoma and lobular carcinoma, are unusual in IDC.
  • Based on pathological studies and a literature review, it is suggested that mammary MCA arises from mucinous metaplasia and macrocystic transformation of ordinary breast carcinoma.
  • [MeSH-major] Breast Neoplasms / pathology. Carcinoma, Ductal, Breast / pathology. Cystadenocarcinoma, Mucinous / pathology. Neoplasms, Second Primary / pathology. Ovarian Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Lymph Node Excision. Mastectomy, Radical. Metaplasia. Middle Aged

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  • (PMID = 18801076.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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100. Khan AW, Sheikh SH, Rahman MA: Results of emergency appendectomy for appendicular mass. Mymensingh Med J; 2007 Jul;16(2):209-13
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  • 342(30%) patients had appendix abscess and 228(19.96%) had loculated collection.
  • Eight patients had tuberculosis and four had carcinoma in addition.
  • It seems that emergency appendectomy could safely be done in appendix mass without any increased risk of mortality and morbidity.

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  • (PMID = 17703161.001).
  • [ISSN] 1022-4742
  • [Journal-full-title] Mymensingh medical journal : MMJ
  • [ISO-abbreviation] Mymensingh Med J
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] Bangladesh
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