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1. McQuellon RP, Russell GB, Shen P, Stewart JH 4th, Saunders W, Levine EA: Survival and health outcomes after cytoreductive surgery with intraperitoneal hyperthermic chemotherapy for disseminated peritoneal cancer of appendiceal origin. Ann Surg Oncol; 2008 Jan;15(1):125-33
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Survival and health outcomes after cytoreductive surgery with intraperitoneal hyperthermic chemotherapy for disseminated peritoneal cancer of appendiceal origin.
  • BACKGROUND: Cytoreductive surgery with intraperitoneal hyperthermic chemotherapy for peritoneal carcinomatosis of appendiceal origin can alleviate symptoms and prolong survival.
  • METHODS: Patients underwent cytoreductive surgery and intraperitoneal hyperthermic chemotherapy for peritoneal cancer.
  • Patients completed questionnaires consisting of demographic information and the Functional Assessment of Cancer Therapy, the SF-36 Medical Outcomes Study survey, the Center for Epidemiologic Studies-Depression Scale, and the ECOG Performance Status Rating before (T1) and after surgery at 3 (T2), 6 (T3), 12 (T4), and 24 (T5) months.
  • CONCLUSIONS: Although complications can affect short-term recovery, survival in appendix cancer patients with peritoneal cancer is good and for some can be achieved without major decrements in QOL at 1 year.
  • [MeSH-major] Adenocarcinoma / mortality. Appendiceal Neoplasms / mortality. Chemotherapy, Cancer, Regional Perfusion. Hyperthermia, Induced. Peritoneal Neoplasms / mortality

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  • (PMID = 18030535.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / K08 CA131482
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 50SG953SK6 / Mitomycin
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2. Thirunavukarasu P, Sathaiah M, Singla S, Sukumar S, Karunamurthy A, Pragatheeshwar KD, Lee KK, Zeh H 3rd, Kane KM, Bartlett DL: Medullary carcinoma of the large intestine: a population based analysis. Int J Oncol; 2010 Oct;37(4):901-7
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  • Medullary carcinoma (MC) of the colorectum is a relatively new histological type of adenocarcinoma characterized by poor glandular differentiation and intraepithelial lymphocytic infiltrate.
  • Mean age at diagnosis was 69.3 (+/-12.5) years, with incidence increasing with age.
  • There were no cases reliably identified in the rectum or appendix.
  • [MeSH-major] Adenocarcinoma / epidemiology. Carcinoma, Medullary / epidemiology. Colorectal Neoplasms / epidemiology

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  • (PMID = 20811712.001).
  • [ISSN] 1791-2423
  • [Journal-full-title] International journal of oncology
  • [ISO-abbreviation] Int. J. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / T32 CA113263
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen
  • [Other-IDs] NLM/ NIHMS609288; NLM/ PMC4127912
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3. Stewart JH 4th, Shen P, Russell GB, Bradley RF, Hundley JC, Loggie BL, Geisinger KR, Levine EA: Appendiceal neoplasms with peritoneal dissemination: outcomes after cytoreductive surgery and intraperitoneal hyperthermic chemotherapy. Ann Surg Oncol; 2006 May;13(5):624-34
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  • [Title] Appendiceal neoplasms with peritoneal dissemination: outcomes after cytoreductive surgery and intraperitoneal hyperthermic chemotherapy.
  • BACKGROUND: Appendiceal neoplasms frequently present with peritoneal dissemination (PD) and have a clinical course marked by bowel obstruction and subsequent death.
  • Few data have correlated outcome with appendiceal histology after cytoreductive surgery and intraperitoneal hyperthermic chemotherapy (IPHC).
  • We have reviewed our experience with cytoreductive surgery and IPHC for PD from the appendix.
  • METHODS: A total of 110 cases of PD from proven appendiceal neoplasms treated with IPHC were identified from a prospectively managed database.
  • RESULTS: A total of 116 IPHCs were performed on 110 patients for appendiceal PD between 1993 and 2004.
  • Age at presentation (P = .0134), performance status (P < .0001), time between diagnosis and IPHC (P = .0011), resection status (P = .0044), and length of hyperthermic chemoperfusion (P = .0193) were independently associated with survival.
  • CONCLUSIONS: The data show that long-term survival is anticipated in most patients who are treated with cytoreduction and IPHC for appendiceal PD.
  • In all, this work establishes a framework for the consideration of IPHC in future trials for appendiceal PD.
  • [MeSH-major] Adenocarcinoma, Mucinous / drug therapy. Adenocarcinoma, Mucinous / surgery. Appendiceal Neoplasms / pathology. Peritoneal Neoplasms / drug therapy. Peritoneal Neoplasms / surgery

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  • [CommentIn] Ann Surg Oncol. 2006 May;13(5):597-9 [16538404.001]
  • (PMID = 16538401.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / K08 CA131482
  • [Publication-type] Journal Article
  • [Publication-country] United States
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4. Vang R, Gown AM, Barry TS, Wheeler DT, Ronnett BM: Immunohistochemistry for estrogen and progesterone receptors in the distinction of primary and metastatic mucinous tumors in the ovary: an analysis of 124 cases. Mod Pathol; 2006 Jan;19(1):97-105
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  • Immunohistochemical studies were performed on 124 mucinous tumors, including 52 primary ovarian tumors (30 atypical proliferative (borderline) mucinous tumors of gastrointestinal type, 11 atypical proliferative (borderline) mucinous tumors of seromucinous (endocervical-like) type, and 11 invasive mucinous carcinomas of usual (gastrointestinal) type) and 72 metastatic mucinous carcinomas in the ovary (primary sites: colorectum (24), pancreas (13), endocervix (eight), stomach (four), gallbladder/bile duct (four), appendix (four), and unknown (15)).
  • [MeSH-major] Adenocarcinoma, Mucinous / secondary. Ovarian Neoplasms / secondary. Receptors, Estrogen / analysis. Receptors, Progesterone / analysis
  • [MeSH-minor] Appendiceal Neoplasms / metabolism. Appendiceal Neoplasms / pathology. Colorectal Neoplasms / metabolism. Colorectal Neoplasms / pathology. Diagnosis, Differential. Female. Gallbladder Neoplasms / metabolism. Gallbladder Neoplasms / pathology. Humans. Immunohistochemistry. Neoplasms, Unknown Primary / metabolism. Neoplasms, Unknown Primary / pathology. Ovary / chemistry. Ovary / pathology. Pancreatic Neoplasms / metabolism. Pancreatic Neoplasms / pathology. Stomach Neoplasms / metabolism. Stomach Neoplasms / pathology. Uterine Cervical Neoplasms / metabolism. Uterine Cervical Neoplasms / pathology

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  • (PMID = 16294196.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Estrogen; 0 / Receptors, Progesterone
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5. Chen CF, Huang CJ, Kang WY, Hsieh JS: Experience with adjuvant chemotherapy for pseudomyxoma peritonei secondary to mucinous adenocarcinoma of the appendix with oxaliplatin/fluorouracil/leucovorin (FOLFOX4). World J Surg Oncol; 2008;6:118
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  • [Title] Experience with adjuvant chemotherapy for pseudomyxoma peritonei secondary to mucinous adenocarcinoma of the appendix with oxaliplatin/fluorouracil/leucovorin (FOLFOX4).
  • So far its diagnosis remains challenging to most clinicians.
  • There was a lot of mucinous ascites, one appendiceal tumor and multiple peritoneal implants disseminated from the subphrenic space to the recto-vesicle pouch.
  • Pseudomyxoma Peritonei caused by mucinous adenocarcinoma of appendiceal origin, was confirmed by histopathology.
  • We performed an excision of the appendiceal tumor combined with copious irrigation and debridement.
  • [MeSH-major] Adenocarcinoma, Mucinous / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Appendiceal Neoplasms / drug therapy. Peritoneal Neoplasms / drug therapy. Pseudomyxoma Peritonei / drug therapy

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  • (PMID = 19014441.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; 04ZR38536J / oxaliplatin; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil
  • [Other-IDs] NLM/ PMC2615010
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6. Bucher P, Gervaz P, Ris F, Oulhaci W, Inan I, Morel P: Laparoscopic versus open resection for appendix carcinoid. Surg Endosc; 2006 Jun;20(6):967-70
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  • [Title] Laparoscopic versus open resection for appendix carcinoid.
  • BACKGROUND: Since an increasing number of appendectomies are performed via laparoscopy, it is crucial to determine the impact of this approach on appendix carcinoid (AC) outcome.
  • Two patients died in the OP group, one due to metastatic carcinoid and the other due to metachronous colorectal cancer.
  • Risk for developing colorectal adenocarcinoma is high in AC patients and warrants follow-up of all patients with colonoscopic screening.
  • [MeSH-major] Appendectomy / methods. Appendiceal Neoplasms / surgery. Carcinoid Tumor / surgery. Laparoscopy

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  • (PMID = 16738993.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
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7. McQuellon RP, Danhauer SC, Russell GB, Shen P, Fenstermaker J, Stewart JH, Levine EA: Monitoring health outcomes following cytoreductive surgery plus intraperitoneal hyperthermic chemotherapy for peritoneal carcinomatosis. Ann Surg Oncol; 2007 Mar;14(3):1105-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The questionnaire consisted of basic demographic items as well as the Functional Assessment of Cancer Therapy-Colon Scale (FACT-C), SF-36 Medical Outcomes Study Health Survey, Center for Epidemiologic Studies-Depression Scale (CES-D), Brief Pain Inventory-Short Form, and ECOG Performance Status Rating.
  • PC originated in primary lesions of the appendix (n = 36); colon/rectum (n = 24); mesothelium (n = 9); ovary (n = 5); stomach (n = 4); and miscellaneous (n = 18).
  • [MeSH-major] Adenocarcinoma / therapy. Chemotherapy, Cancer, Regional Perfusion. Hyperthermia, Induced. Peritoneal Neoplasms / therapy

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  • (PMID = 17206478.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / K08 CA131482
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 50SG953SK6 / Mitomycin
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8. Goere D: [Guest comment on the article: appendiceal mucoceles, pseudomyxoma peritonei, and appendiceal mucinous neoplasms. Update on the contribution of imaging to choice of the surgical approach, J.F. Gillion et al]. J Chir (Paris); 2009 Apr;146(2):167
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  • [Title] [Guest comment on the article: appendiceal mucoceles, pseudomyxoma peritonei, and appendiceal mucinous neoplasms. Update on the contribution of imaging to choice of the surgical approach, J.F. Gillion et al].
  • [Transliterated title] Commentaire invité de l'article "Mucocèles appendiculaires, pseudomyxomes péritonéaux et tumeurs mucosécrétantes du carrefour iléocaecal: apport de l'imagerie dans la stratégie thérapeutique et le choix de la voie d'abord laparoscopique ou classique" par J.-F. Gillion et al.
  • [MeSH-major] Adenocarcinoma, Mucinous / radiography. Appendiceal Neoplasms / radiography. Appendix / radiography. Mucocele / radiography. Peritoneal Neoplasms / radiography. Pseudomyxoma Peritonei / radiography

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  • [CommentOn] J Chir (Paris). 2009 Apr;146(2):150-66 [19552906.001]
  • (PMID = 19540495.001).
  • [ISSN] 0021-7697
  • [Journal-full-title] Journal de chirurgie
  • [ISO-abbreviation] J Chir (Paris)
  • [Language] fre
  • [Publication-type] Comment; Journal Article
  • [Publication-country] France
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9. Alexiou K, Sikalias N, Demonakou M, Mylona SC, Triantafyllis V, Kalogirou A, Antsaklis G: Mucinous adenocarcinoma of the appendix presenting with atypical symptomatology and presence of pseudomyxoma peritonei: a case report. Cases J; 2009;2:9089
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  • [Title] Mucinous adenocarcinoma of the appendix presenting with atypical symptomatology and presence of pseudomyxoma peritonei: a case report.
  • INTRODUCTION: Primary tumors of the appendix are unusual and most of them are carcinoids.
  • CASE PRESENTATION: A female patient with mucous adenocarcinoma of the appendix, which primarily presented as atypical abdominal pain.
  • Diagnosis of the disease was made after appendicectomy and histopathological analysis of the specimen.
  • CONCLUSION: Mucin producing adenocarcinomas of the appendix are a category of rare cancers of the gastrointestinal tract.
  • Although at present they are a well studied pathologic entity, the crucial issue of their preoperative diagnosis remains unsolved.

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  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2803886
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10. Ahmed K, Hoque R, El-Tawil S, Khan MS, George ML: Adenocarcinoma of the appendix presenting as bilateral ureteric obstruction. World J Surg Oncol; 2008;6:23
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  • [Title] Adenocarcinoma of the appendix presenting as bilateral ureteric obstruction.
  • BACKGROUND: Adenocarcinoma of the vermiform appendix is a rare neoplasm of the gastrointestinal tract.
  • These presentations reflect various stages of a locally expanding tumour causing luminal obstruction of appendix.
  • CASE PRESENTATION: We report a case of appendicular adenocarcinoma found unexpectedly in a 43 year old male who presented with urinary symptoms.
  • Histopathology revealed well differentiated adenocarcinoma with signet ring morphology with multiple lymph node involvement.
  • Every attempt should be made to make a precise diagnosis through all the available means to direct the treatment along correct lines.
  • [MeSH-major] Adenocarcinoma / complications. Adenocarcinoma / diagnosis. Appendiceal Neoplasms / complications. Appendiceal Neoplasms / diagnosis. Ureteral Obstruction / etiology

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  • (PMID = 18291037.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2277416
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11. García Lozano A, Vázquez Tarrago A, Castro García C, Richart Aznar J, Gómez Abril S, Martínez Abad M: [Mucocele of the appendix: Presentation of 31 cases]. Cir Esp; 2010 Feb;87(2):108-12
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  • [Title] [Mucocele of the appendix: Presentation of 31 cases].
  • [Transliterated title] Mucocele apendicular: presentación de 31 casos.
  • Mucocele of the appendix is a very uncommon disease estimated to be seen in 0.2-0.3% of all appendectomies (0.28% in our series).
  • The term "mucocele" means dilation of the appendix due to mucus, caused either by a benign process or a malignant one (cystadenoma or adenocarcinoma).
  • The appendix was removed in all cases; five by laparoscopy, with caecal resection in 8 cases (1 was a cystadenocarcinoma) and right ileocolectomy in 15 patients (9 malignant).
  • [MeSH-major] Appendix. Cecal Diseases. Mucocele

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  • [Copyright] Copyright 2009 AEC. Published by Elsevier Espana. All rights reserved.
  • [CommentIn] Cir Esp. 2011 Mar;89(3):200-1; author reply 201-2 [21349501.001]
  • (PMID = 19963210.001).
  • [ISSN] 0009-739X
  • [Journal-full-title] Cirugía española
  • [ISO-abbreviation] Cir Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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12. Hervieu V: [Appendicular pathology. Diffuse mucous hyperplasia]. Ann Pathol; 2010 Apr;30(2):96-100
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  • [Transliterated title] Pathologie de l'appendice. Cas no 1. Hyperplasie muqueuse diffuse.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Appendix / pathology. Cecal Diseases / pathology. Intestinal Mucosa / pathology
  • [MeSH-minor] Adenocarcinoma / complications. Adenocarcinoma / surgery. Aged. Appendectomy. Colectomy. Colonic Neoplasms / complications. Colonic Neoplasms / surgery. Diagnosis, Differential. Humans. Hyperplasia. Intestinal Polyps / diagnosis. Male

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  • (PMID = 20451065.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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13. Roy P, Chetty R: Goblet cell carcinoid tumors of the appendix: An overview. World J Gastrointest Oncol; 2010 Jun 15;2(6):251-8
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  • [Title] Goblet cell carcinoid tumors of the appendix: An overview.
  • Goblet cell carcinoid is an enigmatic and rare tumor involving the appendix almost exclusively.
  • These may be of signet ring cell type or poorly differentiated adenocarcinoma.
  • Recently molecular studies have shown these tumors to lack the signatures of adenocarcinoma but they have some changes similar to that of ileal carcinoids (allelic loss of chromosome 11q, 16q and 18q).
  • The natural history of GCC is intermediate between carcinoids and adenocarcinomas of the appendix.

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  • (PMID = 21160637.001).
  • [ISSN] 1948-5204
  • [Journal-full-title] World journal of gastrointestinal oncology
  • [ISO-abbreviation] World J Gastrointest Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2998842
  • [Keywords] NOTNLM ; Appendiceal neoplasm / Goblet cell carcinoid / Mucin-producing neuroendocrine tumor of appendix
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14. Sieren LM, Collins JN, Weireter LJ, Britt RC, Reed SF, Novosel TJ, Britt LD: The incidence of benign and malignant neoplasia presenting as acute appendicitis. Am Surg; 2010 Aug;76(8):808-11
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  • It is most often secondary to lymphoid hyperplasia, however it can also result from obstruction of the appendiceal lumen by a mass.
  • We retrospectively reviewed all patients admitted with the diagnosis of appendicitis to our Acute Care Surgery Service from July 1, 2007 to June 30, 2009.
  • Final pathology revealed four colonic adenocarcinoma; three mucinous tumors; one carcinoid; one endometrioma; and one patient had a combination of a mucinous cystadenoma, a carcinoid tumor, and endometriosis of the appendix.
  • Colonic and appendiceal neoplasia are not unusual etiologies of appendicitis.
  • [MeSH-major] Appendicitis / diagnosis. Neoplasms / diagnosis
  • [MeSH-minor] Acute Disease. Adult. Age Factors. Aged. Appendiceal Neoplasms / diagnosis. Diagnosis, Differential. Digestive System Neoplasms / diagnosis. Female. Humans. Male. Middle Aged. Retrospective Studies. Tomography, X-Ray Computed

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  • (PMID = 20726408.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. Hristov AC, Young RH, Vang R, Yemelyanova AV, Seidman JD, Ronnett BM: Ovarian metastases of appendiceal tumors with goblet cell carcinoidlike and signet ring cell patterns: a report of 30 cases. Am J Surg Pathol; 2007 Oct;31(10):1502-11
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  • [Title] Ovarian metastases of appendiceal tumors with goblet cell carcinoidlike and signet ring cell patterns: a report of 30 cases.
  • Synchronous and metachronous ovarian and appendiceal mucinous tumors are often the subject of diagnostic consultations in gynecologic pathology practices to address whether the tumors are independent neoplasms or related as primary and metastasis.
  • The ovarian and appendiceal tumors exhibited a variety of patterns of differentiation, including signet ring cell and glandular, with all displaying some goblet cell carcinoidlike patterns (nests, islands, cords, or cryptlike tubules with goblet cells); teratomatous elements were not identified in any ovarian tumors.
  • Chromogranin was expressed in 6 of 16 appendiceal tumors (mean/median: 11.9%/0%; range: 0% to 70%) and synaptophysin was expressed in 6 of 15 of these (mean/median: 16.7%/0%; range: 0% to 90%).
  • The clinicopathologic features of these ovarian tumors indicate they should be labeled as metastatic appendiceal adenocarcinomas rather than as goblet cell carcinoid tumors both to reflect their behavior and help distinguish them from the rare true primary ovarian goblet cell carcinoid tumors.
  • In cases in which the primary tumor is not already evident, their "goblet cell carcinoidlike" patterns should direct attention to the appendix as a possible source.
  • [MeSH-major] Adenocarcinoma / secondary. Appendiceal Neoplasms / pathology. Carcinoid Tumor / secondary. Carcinoma, Signet Ring Cell / secondary. Ovarian Neoplasms / secondary

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  • (PMID = 17895750.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chromogranins; 0 / Synaptophysin
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16. Bruin SC, Verwaal VJ, Vincent A, van't Veer LJ, van Velthuysen ML: A clinicopathologic analysis of peritoneal metastases of colorectal and appendiceal origin. Ann Surg Oncol; 2010 Sep;17(9):2330-40
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  • [Title] A clinicopathologic analysis of peritoneal metastases of colorectal and appendiceal origin.
  • OBJECTIVE: To predict clinical outcome by classification of peritoneal metastases (PM) of colorectal or appendiceal origin.
  • BACKGROUND: This study investigates whether standardized histological classification can predict outcome for PM of colorectal or appendiceal origin treated with cytoreduction and hyperthermic intraperitoneal chemotherapy (HIPEC).
  • Of PM originating from an appendix tumor, 29% were of non-DPAM type.
  • [MeSH-major] Adenocarcinoma, Mucinous / secondary. Appendiceal Neoplasms / pathology. Colorectal Neoplasms / pathology. Peritoneal Neoplasms / secondary

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  • (PMID = 20232161.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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17. Trivedi AN, Levine EA, Mishra G: Adenocarcinoma of the appendix is rarely detected by colonoscopy. J Gastrointest Surg; 2009 Apr;13(4):668-75
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  • [Title] Adenocarcinoma of the appendix is rarely detected by colonoscopy.
  • INTRODUCTION: Appendiceal tumors represent a subset of colonic neoplasms that frequently defy early diagnosis only to present at advanced stage with peritoneal metastasis.
  • The aim of this study is to determine the diagnostic yield of colonoscopy in detecting appendiceal lesions in patients with appendiceal adenocarcinoma and pseudomyxoma peritonei.
  • METHODS: We reviewed clinicopathologic data on 121 consecutive patients with histologically confirmed appendiceal adenocarcinoma with pseudomyxoma peritonei presenting to our institution for intraperitoneal hyperthermic chemotherapy (IPHC) and cytoreductive surgery between February, 1993 and August, 2007, focusing on the colonoscopy findings.
  • Abnormal findings included seven patients with appendiceal lesions (11%), 12 patients with cecal abnormalities (19%), and 28 patients with polyps (44%).
  • CONCLUSIONS: Appendiceal abnormalities are infrequently seen on colonoscopy and rarely yield a diagnostic biopsy in patients with appendiceal carcinoma.
  • We found that nearly 42% of patients with carcinoma of the appendix have synchronous colonic polyps, a much higher prevalence than would be expected, supporting a role for a perioperative colonoscopy.
  • [MeSH-major] Adenocarcinoma / diagnosis. Appendiceal Neoplasms / diagnosis. Colonoscopy. Peritoneal Neoplasms / diagnosis. Pseudomyxoma Peritonei / diagnosis

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  • (PMID = 19089515.001).
  • [ISSN] 1873-4626
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
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18. Avenel P, McKendrick A, Silapaswan S, Kolachalam R, Kestenberg W, Ferguson L, Jacobs MJ, Goriel Y, Mittal V: Gastrointestinal carcinoids: an increasing incidence of rectal distribution. Am Surg; 2010 Jul;76(7):759-63
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  • Other sites of carcinoid tumors were the appendix (8.3%), colon (8.3%), and duodenum (3.8%).
  • CT was not helpful in preoperative diagnosis of carcinoid tumor.
  • Screening colonoscopy, in addition to decreasing colorectal adenocarcinoma mortality, is useful in diagnosing carcinoid tumors at an earlier stage and in decreasing mortality from malignant colorectal carcinoid tumors.

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  • (PMID = 20698387.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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19. Gatalica Z, Foster JM, Loggie BW: Low grade peritoneal mucinous carcinomatosis associated with human papilloma virus infection: case report. Croat Med J; 2008 Oct;49(5):669-73
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  • The vast majority of the pseudomyxoma peritonei are associated with mucinous neoplasms of the appendix.
  • We describe a case of pseudomyxoma peritonei associated with mucinous adenocarcinoma of the cervix in a 60-year-old woman.
  • The patient developed low grade mucinous peritoneal carcinomatosis 8 years after hysterectomy for cervical adenocarcinoma.
  • HPV has been previously associated with development of cervical carcinomas (both squamous and mucinous) but neither has cervical adenocarcinoma nor HPV been implicated in development of pseudomyxoma peritonei.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Papillomavirus Infections / complications. Peritoneal Neoplasms / diagnosis. Pseudomyxoma Peritonei / diagnosis. Pseudomyxoma Peritonei / etiology. Tumor Virus Infections / complications
  • [MeSH-minor] Adenocarcinoma / surgery. Female. Human papillomavirus 11. Human papillomavirus 16. Human papillomavirus 6. Humans. Middle Aged. Uterine Cervical Neoplasms / surgery

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  • (PMID = 18925701.001).
  • [ISSN] 1332-8166
  • [Journal-full-title] Croatian medical journal
  • [ISO-abbreviation] Croat. Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
  • [Other-IDs] NLM/ PMC2582360
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20. Bodin R, Peycru T, Schwartz A, Jarry J, Pommier N, Durand-Dastes F: Tubulovillous adenoma of the appendix: a case report and review of the literature. Gastroenterol Clin Biol; 2010 Nov;34(11):633-5
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  • [Title] Tubulovillous adenoma of the appendix: a case report and review of the literature.
  • Treatment is most often limited to appendectomy, but in the event of incomplete excision or associated adenocarcinoma, right hemicolectomy may be required.
  • [MeSH-major] Adenoma, Villous / surgery. Appendectomy. Appendiceal Neoplasms / surgery

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  • [Copyright] Copyright © 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20739133.001).
  • [ISSN] 0399-8320
  • [Journal-full-title] Gastroentérologie clinique et biologique
  • [ISO-abbreviation] Gastroenterol. Clin. Biol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] France
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21. Tang LH, Shia J, Soslow RA, Dhall D, Wong WD, O'Reilly E, Qin J, Paty P, Weiser MR, Guillem J, Temple L, Sobin LH, Klimstra DS: Pathologic classification and clinical behavior of the spectrum of goblet cell carcinoid tumors of the appendix. Am J Surg Pathol; 2008 Oct;32(10):1429-43
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  • [Title] Pathologic classification and clinical behavior of the spectrum of goblet cell carcinoid tumors of the appendix.
  • Appendiceal tumors exhibiting both neuroendocrine and glandular differentiation are uncommon and have caused difficulty in pathologic classification, prediction of prognosis, and clinical management.
  • Previously, such lesions have been variously designated as adenocarcinoid, goblet cell carcinoid (GCC), and mixed adenocarcinoma carcinoid.
  • In this study, we undertook a retrospective investigation of 63 such cases and classified them as typical GCC (group A) and adenocarcinoma ex GCC on the basis of the histologic features of the tumor at the primary site.
  • The adenocarcinoma ex GCC group was further divided into signet ring cell type (group B) and poorly differentiated adenocarcinoma type (group C).
  • The clinical characteristics and prognosis were compared within these groups and with conventional de novo appendiceal adenocarcinomas.
  • In conclusion, GCC is a distinctive appendiceal neoplasm that exhibits unique pathologic features and clinical behavior.
  • They display a spectrum of histologic features and possess the potential to transform to an adenocarcinoma phenotype of either signet ring cell or poorly differentiated adenocarcinoma types.
  • Surgical management with right hemicolectomy is recommended after appendectomy for most cases, particularly those with an adenocarcinoma component (groups B and C).
  • [MeSH-major] Adenocarcinoma / pathology. Appendiceal Neoplasms / pathology. Carcinoid Tumor / pathology. Carcinoma, Signet Ring Cell / pathology


22. Ko YH, Park SH, Jung CK, Won HS, Hong SH, Park JC, Roh SY, Woo IS, Kang JH, Hong YS, Byun JH: Clinical characteristics and prognostic factors for primary appendiceal carcinoma. Asia Pac J Clin Oncol; 2010 Mar;6(1):19-27
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  • [Title] Clinical characteristics and prognostic factors for primary appendiceal carcinoma.
  • AIM: Primary adenocarcinoma of the appendix is a rare malignancy.
  • This study assessed prognostic factors affecting the clinical outcome in patients with appendiceal neoplasms.
  • Of the 34 patients who underwent curative resections of primary appendiceal carcinomas, the 3- and 5-year disease-free survival rates were 66.4% and 53.3%, respectively.
  • CONCLUSION: High tumor grade and advanced stage were significantly predictive of poor survival outcome in patients with primary appendiceal carcinomas.
  • [MeSH-major] Adenocarcinoma / pathology. Appendiceal Neoplasms / pathology

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  • (PMID = 20398034.001).
  • [ISSN] 1743-7563
  • [Journal-full-title] Asia-Pacific journal of clinical oncology
  • [ISO-abbreviation] Asia Pac J Clin Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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23. Gustafsson BI, Siddique L, Chan A, Dong M, Drozdov I, Kidd M, Modlin IM: Uncommon cancers of the small intestine, appendix and colon: an analysis of SEER 1973-2004, and current diagnosis and therapy. Int J Oncol; 2008 Dec;33(6):1121-31
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  • [Title] Uncommon cancers of the small intestine, appendix and colon: an analysis of SEER 1973-2004, and current diagnosis and therapy.
  • Although colon adenocarcinomas constitute approximately 90% of all malignant intestinal neoplasia, the remaining 10% of tumors in the small intestine (SI), appendix and colon are clinically relevant since their late presentation due to a paucity of overt symptoms culminates in a high mortality rate despite the fact that many such lesions are not intrinsically aggressive neoplasia.
  • Thus, neuroendocrine tumors (NETs), adenocarcinomas (except for colonic), lymphomas, sarcomas and GI stromal tumors (GISTs) of the SI, appendix and colon, while relatively rare, represent an under-recognized and underserved group of lesions.
  • [MeSH-major] Appendiceal Neoplasms / epidemiology. Colonic Neoplasms / epidemiology. Intestinal Neoplasms / epidemiology. Intestine, Small / pathology
  • [MeSH-minor] Adenocarcinoma / epidemiology. Gastrointestinal Stromal Tumors / epidemiology. Humans. Lymphoma / epidemiology. Neuroendocrine Tumors / epidemiology. SEER Program. Sarcoma / epidemiology. Survival Analysis. Time Factors. Treatment Outcome. United States / epidemiology

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  • (PMID = 19020744.001).
  • [ISSN] 1019-6439
  • [Journal-full-title] International journal of oncology
  • [ISO-abbreviation] Int. J. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Greece
  • [Number-of-references] 68
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24. Aljarabah MM, Borley NR, Wheeler JM: Appendiceal adenocarcinoma presenting as left-sided large bowel obstruction, a case report and literature review. Int Semin Surg Oncol; 2007;4:20
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  • [Title] Appendiceal adenocarcinoma presenting as left-sided large bowel obstruction, a case report and literature review.
  • BACKGROUND: appendiceal tumours are rare, they may be encountered unexpectedly in any acute or elective abdominal operation, many of these tumours are not appreciated intraoperatively and are diagnosed only during formal histopathological analysis of an appendicectomy specimen.
  • Herein we present a case of appendiceal adenocarcinoma presenting as left-sided large bowel obstruction, we also review the literature of unusual presentations of appendiceal tumours.
  • CASE PRESENTATION: we report a case of left sided large bowel obstruction found to be secondary to an appendiceal adenocarcinoma.
  • The patient presented with abdominal pain, distension and constipation, CT scan showed large bowel obstruction thought to be due to a sigmoid tumour, on laparotomy the appendix was also noted to be abnormal.
  • A separate ileocaecal resection with end ileostomy was also performed, pathology specimens showed that the primary neoplasm was the appendix with metastasis to the distal sigmoid.
  • CONCLUSION: appendiceal tumours are rare, they usually present as acute appendicitis, other presentations are far less common.

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  • [Cites] Br J Surg. 2006 Jul;93(7):783-92 [16775823.001]
  • (PMID = 17662117.001).
  • [ISSN] 1477-7800
  • [Journal-full-title] International seminars in surgical oncology : ISSO
  • [ISO-abbreviation] Int Semin Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1948007
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25. Savchenko IuP, Polovinkin VV, Fedosov SR, Pryn' PS: [Combination of giant mucocele of the appendix and adenocarcinoma of the rectum]. Khirurgiia (Mosk); 2006;(10):57-9
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  • [Title] [Combination of giant mucocele of the appendix and adenocarcinoma of the rectum].
  • [MeSH-major] Adenocarcinoma / complications. Appendiceal Neoplasms / complications. Mucocele / complications. Rectal Neoplasms / complications
  • [MeSH-minor] Aged. Appendectomy. Biopsy. Colectomy. Diagnosis, Differential. Female. Humans. Severity of Illness Index. Tomography, X-Ray Computed

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  • (PMID = 17167911.001).
  • [ISSN] 0023-1207
  • [Journal-full-title] Khirurgiia
  • [ISO-abbreviation] Khirurgiia (Mosk)
  • [Language] rus
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Russia (Federation)
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26. Matsushita M, Ando Y, Omiya M, Uchida K, Nishio A, Okazaki K: Association of "ulcerative appendicitis" and appendiceal adenocarcinoma. Inflamm Bowel Dis; 2009 Sep;15(9):1283
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Association of "ulcerative appendicitis" and appendiceal adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / complications. Appendiceal Neoplasms / complications. Appendicitis / complications. Colitis, Ulcerative / complications
  • [MeSH-minor] Diagnosis, Differential. Humans. Mucocele / etiology

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  • [CommentOn] Inflamm Bowel Dis. 2008 Jun;14(6):873-4 [18275069.001]
  • (PMID = 18951377.001).
  • [ISSN] 1536-4844
  • [Journal-full-title] Inflammatory bowel diseases
  • [ISO-abbreviation] Inflamm. Bowel Dis.
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
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27. López-Deogracias M, Naranjo-Gozalo S, Sánchez-Moreno L, Gómez-Fleitas M: [Duplicated appendix in the presence of an adenocarcinoma]. Cir Esp; 2008 Jun;83(6):333
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Duplicated appendix in the presence of an adenocarcinoma].
  • [Transliterated title] Duplicación apendicular con presencia de adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / complications. Appendix / abnormalities. Colonic Neoplasms / complications

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  • [ErratumIn] Cir Esp. 2008 Oct;84(4):238. López-Deogracias, Marta [corrected to López-Deogracias, Maite]
  • (PMID = 18570855.001).
  • [ISSN] 0009-739X
  • [Journal-full-title] Cirugía española
  • [ISO-abbreviation] Cir Esp
  • [Language] spa
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Spain
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28. Fujitani K, Ogawa H, Takeda M, Hirao M, Yasui M, Kashiwazaki M, Ikenaga M, Miyazaki M, Mishima H, Nakamori S, Manoh M, Tsujinaka T: [A case report of pseudomyxoma peritonei demonstrating complete response after intensive therapy consisting of cytoreductive surgery and adjuvant chemotherapy with paclitaxel and S-1]. Gan To Kagaku Ryoho; 2008 Mar;35(3):523-7
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  • A 74-year-old male with diffuse gelatinous ascites underwent cytoreductive surgery including ileocecal resection and greater omentectomy.
  • Pathology revealed mucinous adenocarcinoma with low-grade malignancy originating in the appendix with disseminated peritoneal adenomucinosis, which was diagnostic of pseudomyxoma peritonei.

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  • (PMID = 18347410.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Drug Combinations; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid; P88XT4IS4D / Paclitaxel
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29. Khunamornpong S, Suprasert P, Chiangmai WN, Siriaunkgul S: Metastatic tumors to the ovaries: a study of 170 cases in northern Thailand. Int J Gynecol Cancer; 2006 Jan-Feb;16 Suppl 1:132-8
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  • The medical records, the radiologic findings, and the follow-up outcome in the cases suspicious or diagnostic of metastases were reviewed to confirm the diagnosis and to determine the primary sites.
  • Nongynecologic metastatic tumors were from large intestine (31%), stomach (14%), intrahepatic bile duct (10%), breast (9%), extrahepatic bile duct/gallbladder (7%), appendix (5%), hematologic tumors (3%), others (4%), and unknown primary site (16%).
  • However, the distribution of the primary sites was different and was correlated with the cancer incidence in Thai women.
  • [MeSH-major] Adenocarcinoma, Mucinous / epidemiology. Ovarian Neoplasms / epidemiology

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  • (PMID = 16515581.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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30. Okada N, Ishibashi K, Nakada H, Miyazaki T, Sobajima J, Gonda T, Ishida H: [Five cases of pseudomyxoma peritonei underwent abdominal lavage and administering CDDP]. Gan To Kagaku Ryoho; 2007 Nov;34(12):1955-7
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  • These primary lesions contained one case of pancreas and four cases of appendix.
  • Histological types contained one case of well differentiated adenocarcinoma and four cases of signet ring cell carcinoma.

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  • (PMID = 18219863.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] Q20Q21Q62J / Cisplatin
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31. Vang R, Gown AM, Farinola M, Barry TS, Wheeler DT, Yemelyanova A, Seidman JD, Judson K, Ronnett BM: p16 expression in primary ovarian mucinous and endometrioid tumors and metastatic adenocarcinomas in the ovary: utility for identification of metastatic HPV-related endocervical adenocarcinomas. Am J Surg Pathol; 2007 May;31(5):653-63
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Immunohistochemical expression of p16 was assessed in 195 tumors, including 98 primary ovarian tumors (51 mucinous, 47 endometrioid, and 4 mixed mucinous-endometrioid tumors), 93 metastatic adenocarcinomas of known primary sites (colorectum: 34, endocervix: 19, pancreaticobiliary tract: 17, appendix: 7, stomach: 5), 11 metastatic adenocarcinomas of unknown origin (7 established as noncervical), and 4 adenocarcinomas of uncertain (primary ovarian vs. metastatic) origin.
  • Diffuse (>75% positive tumor cells) moderate to strong p16 expression is a sensitive (100%) and specific (97%) marker for identifying HPV-related endocervical adenocarcinomas metastatic to the ovary among the primary ovarian tumors and metastatic adenocarcinomas from other sites that are in the differential diagnosis of ovarian tumors having mucinous and/or endometrioid/endometrioidlike differentiation. p16 is useful as part of a panel of immunohistochemical markers for distinguishing primary ovarian tumors from metastases and, when diffusely positive, can suggest the cervix as a potential primary site for metastatic adenocarcinomas of unknown origin.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenocarcinoma, Mucinous / metabolism. Carcinoma, Endometrioid / metabolism. Cyclin-Dependent Kinase Inhibitor p16 / metabolism. Ovarian Neoplasms / metabolism. Uterine Cervical Neoplasms / metabolism
  • [MeSH-minor] Biomarkers, Tumor / metabolism. DNA, Viral / analysis. Diagnosis, Differential. Female. Humans. Immunoenzyme Techniques. In Situ Hybridization. Papillomaviridae / genetics. Papillomavirus Infections. Polymerase Chain Reaction


32. Iwuagwu OC, Jameel JK, Drew PJ, Hartley JE, Monson JR: Primary carcinoma of the appendix - Hull series. Dig Surg; 2005;22(3):163-7
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  • [Title] Primary carcinoma of the appendix - Hull series.
  • BACKGROUND: Appendiceal carcinoma (AC) is a rare entity that does not have a well-defined treatment strategy.
  • At presentation, most patients are clinically thought to have appendicitis and the diagnosis is made only by formal histology.
  • Once the diagnosis of AC is made, patients are treated by various strategies including surgery, chemotherapy depending on nodal status of the disease.
  • The histopathology reports of all appendiceal specimens removed were traced.
  • We did not include patients with primary carcinoid tumours or secondary adenocarcinoma.
  • Five patients survived at least 4 years from the time of diagnosis.
  • [MeSH-major] Adenocarcinoma, Mucinous / surgery. Appendiceal Neoplasms / surgery

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  • [Copyright] Copyright (c) 2005 S. Karger AG, Basel.
  • (PMID = 16037676.001).
  • [ISSN] 0253-4886
  • [Journal-full-title] Digestive surgery
  • [ISO-abbreviation] Dig Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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33. Kuester D, Dalicho S, Mönkemüller K, Benedix F, Lippert H, Guenther T, Roessner A, Meyer F: Synchronous multifocal colorectal carcinoma in a patient with delayed diagnosis of ulcerative pancolitis. Pathol Res Pract; 2008;204(12):905-10
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  • [Title] Synchronous multifocal colorectal carcinoma in a patient with delayed diagnosis of ulcerative pancolitis.
  • Patients with ulcerative colitis face an increased lifetime risk of developing colorectal cancer.
  • Regardless of the diagnosis and medical advice, the patient initially refused therapy, and proctocolectomy was delayed for 12 months.
  • Furthermore, a mucinous cystadenoma was found in the appendix in the setting of ulcerative colitis.
  • [MeSH-major] Adenocarcinoma / pathology. Colitis, Ulcerative / complications. Colitis, Ulcerative / pathology. Colorectal Neoplasms / pathology
  • [MeSH-minor] Adult. Appendiceal Neoplasms / pathology. Cystadenoma, Mucinous / pathology. Humans. Male. Neoplasm Staging. Neoplasms, Multiple Primary / pathology

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  • [CommentIn] Zentralbl Chir. 2015 Dec;140(6):624-6 [25076166.001]
  • (PMID = 18842350.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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34. Cirocco WC: Right hemicolectomy remains the treatment of choice for adenocarcinoma of the appendix. Gastrointest Endosc; 2005 May;61(6):791; author reply 792
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Right hemicolectomy remains the treatment of choice for adenocarcinoma of the appendix.
  • [MeSH-major] Adenocarcinoma / surgery. Appendiceal Neoplasms / surgery. Colectomy / methods. Decision Making

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  • [CommentOn] Gastrointest Endosc. 2004 May;59(6):731-3 [15114326.001]
  • (PMID = 15856001.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Case Reports; Comment; Letter
  • [Publication-country] United States
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36. Szanto I, Rubbia-Brandt L, Kiss P, Steger K, Banfi B, Kovari E, Herrmann F, Hadengue A, Krause KH: Expression of NOX1, a superoxide-generating NADPH oxidase, in colon cancer and inflammatory bowel disease. J Pathol; 2005 Oct;207(2):164-76
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  • [Title] Expression of NOX1, a superoxide-generating NADPH oxidase, in colon cancer and inflammatory bowel disease.
  • In this study we characterized NOX1 expression in human colon samples derived from healthy control subjects and patients with colon cancer or inflammatory bowel disease (IBD).
  • In addition, a population of lymphocytes, particularly in the appendix, showed NOX1 expression.
  • [MeSH-minor] Adenocarcinoma / metabolism. Adult. Aged. Aged, 80 and over. Animals. Colitis, Ulcerative / metabolism. Colon / metabolism. Crohn Disease / metabolism. Female. Humans. Ileum / metabolism. In Situ Hybridization / methods. Lymphocytes / metabolism. Male. Mice. Mice, Inbred BALB C. Middle Aged. Neoplasm Proteins / analysis. RNA, Messenger / analysis. RNA, Neoplasm / analysis. Rectal Neoplasms / metabolism. Rectum / metabolism

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  • [Copyright] Copyright (c) 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
  • (PMID = 16086438.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Neoplasm Proteins; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 0 / Reactive Oxygen Species; EC 1.6.3.- / NOX1 protein, human; EC 1.6.3.1 / NADPH Oxidase
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37. Shinoda M, Hatano S, Kawakubo H, Kakefuda T, Omori T, Ishii S: Adult cecoanal intussusception caused by cecum cancer: report of a case. Surg Today; 2007;37(9):802-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adult cecoanal intussusception caused by cecum cancer: report of a case.
  • We report a case of cecoanal intussusception caused by cecum cancer in a 29-year-old woman.
  • Laparotomy confirmed that the tumor originated at the bottom of the appendix in the cecum.
  • We performed partial resection of the cecum containing the tumor and appendix.
  • The pathological finding was submucosal adenocarcinoma in adenoma.

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  • [Cites] Dis Colon Rectum. 1988 Aug;31(8):629-31 [3402288.001]
  • [Cites] Anticancer Res. 2000 Nov-Dec;20(6C):4697-700 [11205203.001]
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  • (PMID = 17713738.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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38. You J, Xu L, Zheng GY, Qiu JF: [Diagnosis, treatment, and prognosis of primary appendiceal tumors: analysis of 37 cases]. Zhonghua Yi Xue Za Zhi; 2008 Jul 15;88(27):1909-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Diagnosis, treatment, and prognosis of primary appendiceal tumors: analysis of 37 cases].
  • OBJECTIVE: To investigate the pathology, diagnosis,treatment, and prognosis of primary appendiceal tumors.
  • METHODS: The clinical data of 37 patients with primary tumors of the appendix, 16 males and 21 females, aged 56 +/- 13 (35-87) hospitalized Jan.
  • All 37 cases received surgical operation with the diagnosis confirmed by pathology.
  • The pathological types included carcinoid tumor (n=12), mucinous tumor (n=17), and adenocarcinoma (n=8).
  • The 1, 3, and 5-year survival rates of the primary appendix carcinoid tumor, mucinous tumor, and adenocarcinoma were 100.0%, 100.0%, and 91.7%, 100.0%, 86.7%, and 71.5%, and 75.0%, 50.0%, and 50.0% respectively.
  • CONCLUSION: A rare disease, appendiceal tumors lack specific clinical features.
  • Intra-operative exploration and frozen section are very important for diagnosis and operation choice.
  • The prognosis of primary appendix carcinoid tumors is better.
  • [MeSH-major] Appendiceal Neoplasms / diagnosis. Appendiceal Neoplasms / surgery

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  • (PMID = 19040005.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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39. Yantiss RK, Shia J, Klimstra DS, Hahn HP, Odze RD, Misdraji J: Prognostic significance of localized extra-appendiceal mucin deposition in appendiceal mucinous neoplasms. Am J Surg Pathol; 2009 Feb;33(2):248-55
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prognostic significance of localized extra-appendiceal mucin deposition in appendiceal mucinous neoplasms.
  • Appendiceal mucinous neoplasms confined to the mucosa are benign, whereas those with disseminated peritoneal mucin deposits often follow an indolent, but malignant, course.
  • Not infrequently, appendiceal mucinous neoplasms are associated with localized periappendiceal mucin deposits, but lack diffuse peritoneal involvement.
  • Although some investigators consider both acellular and cellular periappendiceal mucin to pose no, or minimal, risk for recurrent disease, the biologic importance of localized extra-appendiceal mucin has never been evaluated.
  • We identified 65 patients with appendiceal mucinous neoplasms, all of whom had localized periappendiceal mucin deposits without diffuse peritoneal involvement, and assessed them for the presence of extra-appendiceal epithelium and clinical outcome.
  • Most (77%) cases showed acellular periappendiceal mucin, but 15 (23%) had scant extra-appendiceal epithelium (range: 1 to 12 cell clusters).
  • Thus, patients with appendiceal mucinous neoplasms and acellular periappendiceal mucin are unlikely to develop recurrent disease.
  • However, microscopic examination of the entire appendix is necessary, as lesions with extra-appendiceal tumor cells are more likely to progress to disseminated disease and result in death of the patient, even if the mucin is paucicellular and confined to the periappendiceal region.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Appendiceal Neoplasms / pathology. Mucins / metabolism

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  • (PMID = 18852679.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Mucins
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40. Uharcek P, Mlyncek M, Durcanský D: Appendiceal adenocarcinoma presenting with bilateral Krukenberg tumors. J Obstet Gynaecol Res; 2007 Apr;33(2):211-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Appendiceal adenocarcinoma presenting with bilateral Krukenberg tumors.
  • Primary appendiceal malignancy metastatic to the ovaries is a condition that may mimic advanced stage ovarian cancer.
  • A 52-year-old woman referred to our institution for presumed advanced stage of ovarian cancer was found to have primary appendiceal adenocarcinoma metastatic to ovaries at laparotomy.
  • It is important for the gynecologist-oncologist to include tumors of the appendix into the differential diagnosis of any case of ovarian tumor.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Krukenberg Tumor / secondary. Ovarian Neoplasms / secondary

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  • (PMID = 17441899.001).
  • [ISSN] 1341-8076
  • [Journal-full-title] The journal of obstetrics and gynaecology research
  • [ISO-abbreviation] J. Obstet. Gynaecol. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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41. Zermani R, Chelbi E, Farah F, Rameh S, Kourda N, Ferchichi L, Sayari S, Zaouche A, Ben Jilani S: [Serrated adenoma of the appendix associated with colonic adenocarcinoma]. Tunis Med; 2009 Jan;87(1):97
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Serrated adenoma of the appendix associated with colonic adenocarcinoma].
  • [Transliterated title] Adénome festonné de l'appendice associé a un adénocarcinome colique.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma / pathology. Appendiceal Neoplasms / pathology. Colonic Neoplasms / pathology

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  • (PMID = 19522437.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] fre
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Tunisia
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42. Zedníková I, Kuntscher V, Schmiedhuber P, Daum O: [Mucinous adenocarcinoma of the appendix--case report]. Rozhl Chir; 2010 Nov;89(11):682-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Mucinous adenocarcinoma of the appendix--case report].
  • [Transliterated title] Mucinózni adenokarcinom apendixu--kazuistika.
  • The authors are describing a case of a patient with the diagnosis of the appendicular cancer.
  • The 66-year-old patient underwent appendectomy because of signs of acute appendicitis, and than in the next step right-sided hemicolectomy because of histological finding of the mucinous adenocarcinoma of the appendix.
  • Mucinous adenocarcinoma is the most common type of appendicular cancer, none the less this diagnosis is very rare.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Appendiceal Neoplasms / diagnosis

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  • (PMID = 21409802.001).
  • [ISSN] 0035-9351
  • [Journal-full-title] Rozhledy v chirurgii : měsíčník Československé chirurgické společnosti
  • [ISO-abbreviation] Rozhl Chir
  • [Language] cze
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Czech Republic
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43. Rankovic VI, Masirevic VP, Pavlov MJ, Ceranic MS, Milenkovic MG, Simic AP, Kecmanovic DM: Hemodynamic and cardiovascular problems during modified hyperthermic intraperitoneal perioperative chemotherapy. Hepatogastroenterology; 2007 Mar;54(74):364-6
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  • BACKGROUND/AIMS: Cytoreductive surgery and hyperthermic intraperitoneal perioperative chemotherapy (HIPEC) significantly improves patients survival with peritoneal carcinomatosis especially in low-grade tumor e.g. ovarian and appendiceal adenocarcinoma, peritoneal pseudomyxoma and grade I gastric and colorectal cancer.
  • [MeSH-major] Antineoplastic Agents / administration & dosage. Blood Pressure / physiology. Cardiac Output / physiology. Chemotherapy, Cancer, Regional Perfusion / adverse effects. Colorectal Neoplasms / drug therapy. Colorectal Neoplasms / surgery. Heart Rate / physiology. Hyperthermia, Induced / adverse effects. Ovarian Neoplasms / drug therapy. Ovarian Neoplasms / surgery. Peritoneal Neoplasms / drug therapy. Peritoneal Neoplasms / surgery. Postoperative Complications / physiopathology. Pseudomyxoma Peritonei / drug therapy. Pseudomyxoma Peritonei / surgery

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  • (PMID = 17523275.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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44. Skrovina M, Czudek S, Bartos J, Ferák I, Adamcík L, Bezunková E, Vanko R: [The Peutz-Jeghers syndrome--a case review]. Rozhl Chir; 2007 Jan;86(1):24-6
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  • METHODS: The patient who presented with insignificant family history with a diagnosed stenosing tumor of his appendix and histological findings of highly suspected adenocarcinoma, was indicated for surgical revision and right-sided hemicolectomy.
  • [MeSH-major] Diagnostic Errors. Hamartoma / diagnosis. Intestinal Polyps / diagnosis. Peutz-Jeghers Syndrome / diagnosis
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / surgery. Adult. Appendiceal Neoplasms / diagnosis. Appendiceal Neoplasms / surgery. Humans. Male

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  • (PMID = 17416075.001).
  • [ISSN] 0035-9351
  • [Journal-full-title] Rozhledy v chirurgii : měsíčník Československé chirurgické společnosti
  • [ISO-abbreviation] Rozhl Chir
  • [Language] cze
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Czech Republic
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45. Miyazaki K, Satoh H, Sekizawa K: Metastasis to appendix from lung adenocarcinoma. Int J Gastrointest Cancer; 2005;36(1):59-60
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  • [Title] Metastasis to appendix from lung adenocarcinoma.
  • We previously read with interest the case report by Filik et al. (International Journal of Gastrointestinal Cancer, 2003;34:55-58) on appendicular metastases from pancreatic adenocarcinoma.
  • His past medical history included a pneumonectomy of the left lung for locally advanced lung adenocarcinoma 9 mo previously.
  • TNM stage of the original lung cancer was T2N2M0.
  • Endoscopic evaluation revealed no obstruction, but failed to identify mucosal abnormalities in the ileocecal region.
  • He underwent a laparotomy, and tumor of the appendix, 3 x 3 cm in diameter, adhered to the surrounding tissue, but no perforation was seen.
  • The mass was excised in combination with an ileocecal resection, followed by ileocolic anastomosis.
  • Hisotologically, the neoplastic tumor cells infiltrated the submucosa, muscularis, and serosa, but mucosa of the appendix was intact, unremarkable, with no precursor lesion.
  • He was examined at regular periodic follow-ups, but died from lung cancer 12 mo after the resection of the metastatic tumor to the appendix.
  • [MeSH-major] Appendiceal Neoplasms / secondary. Lung Neoplasms / pathology

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  • [CommentOn] Int J Gastrointest Cancer. 2003;34(1):55-8 [15235136.001]
  • [Cites] Pathol Int. 1996 Mar;46(3):216-20 [10846573.001]
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  • (PMID = 16227637.001).
  • [ISSN] 1537-3649
  • [Journal-full-title] International journal of gastrointestinal cancer
  • [ISO-abbreviation] Int J Gastrointest Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Comment; Journal Article
  • [Publication-country] United States
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46. Petrou A, Papalambros A, Katsoulas N, Bramis K, Evangelou K, Felekouras E: Primary appendiceal mucinous adenocarcinoma alongside with situs inversus totalis: a unique clinical case. World J Surg Oncol; 2010;8:49
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  • [Title] Primary appendiceal mucinous adenocarcinoma alongside with situs inversus totalis: a unique clinical case.
  • INTRODUCTION: Mucinous adenocarcinoma is a rare neoplasm of the gastrointestinal tract and one of the three major histological subtypes of the primary appendiceal adenocarcinoma.
  • The most common type of presentation is that of acute appendicitis and the diagnosis is usually occurred after appendectomy.
  • The accurate preoperative diagnosis and management of the above condition represents a real challenge when uncommon anatomic anomalies such intestinal malrotation and situs inversus take place.
  • Both preoperative US and CT scan of the abdomen and pelvis declared situs inversus, with a characteristic thickening in its wall, appendix situated in the left lower quadrant of the abdomen.
  • These findings reached to the diagnosis of acute appendicitis with situs inversus and a standard appendicectomy was performed.
  • Pathologic evaluation established primary mucinous adenocarcinoma of the appendix and three months afterwards the patient underwent a subsequent extended left hemicolectomy.
  • CONCLUSION: In conclusion, the occurrence of primary appendiceal mucinous adenocarcinoma along with situs inversus, definitely accounts as a unique clinical case.
  • Even synchronous manifestation of primary mucinous adenocarcinoma of the appendix and situs inversus totalis represents an unusual anatomo-pathological entity, all physicians should be familiar having the knowledge to make an appropriate and accurate diagnosis that will lead to prompt and correct treatment.
  • [MeSH-major] Adenocarcinoma, Mucinous / complications. Appendiceal Neoplasms / complications. Situs Inversus / complications

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  • (PMID = 20525349.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2894825
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47. Smeenk RM, van Velthuysen ML, Verwaal VJ, Zoetmulder FA: Appendiceal neoplasms and pseudomyxoma peritonei: a population based study. Eur J Surg Oncol; 2008 Feb;34(2):196-201
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Appendiceal neoplasms and pseudomyxoma peritonei: a population based study.
  • BACKGROUND: Pseudomyxoma peritonei (PMP) is a rare disease with an estimated incidence of 1 per million per year, and is thought to originate usually from an appendiceal mucinous epithelial neoplasm.
  • METHODS: The nationwide pathology database of the Netherlands (PALGA) was searched for the incidence of all appendectomies, the incidence of primary epithelial appendiceal lesions and the incidence and pathology history of patients with PMP.
  • An appendiceal lesion was found in 1482 appendiceal specimens (0.9%).
  • Coincidentally, an additional epithelial colonic neoplasm was found in 13% of patients with an appendiceal epithelial lesion.
  • A mucinous epithelial neoplasm was identified in 0.3% (73% benign, 27% malignant) of appendiceal specimens and 20% of these patients developed PMP.
  • The primary site was identified in 68% and dominated by the appendix (82%).
  • CONCLUSIONS: Primary epithelial lesions of the appendix are rare.
  • [MeSH-major] Adenocarcinoma, Mucinous / epidemiology. Appendiceal Neoplasms / epidemiology. Neoplasms, Multiple Primary / epidemiology. Peritoneal Neoplasms / epidemiology. Pseudomyxoma Peritonei / epidemiology

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  • (PMID = 17524597.001).
  • [ISSN] 1532-2157
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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48. Tynan JR, Marshall GB, Gray RR: Answer to case of the month #107. Appendiceal mucocele as a presentation of mucinous adenocarcinoma. Can Assoc Radiol J; 2006 Apr;57(2):117-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Answer to case of the month #107. Appendiceal mucocele as a presentation of mucinous adenocarcinoma.
  • [MeSH-major] Adenocarcinoma, Mucinous / complications. Appendiceal Neoplasms / complications. Appendix. Cecal Diseases / etiology. Mucocele / etiology

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  • (PMID = 16944685.001).
  • [ISSN] 0846-5371
  • [Journal-full-title] Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes
  • [ISO-abbreviation] Can Assoc Radiol J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
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49. Wu CL, Yu CC: Amyand's hernia with adenocarcinoid tumor. Hernia; 2010 Aug;14(4):423-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Also, neoplasms of the appendix is quite uncommon.
  • Adenocarcinoid tumor of the appendix was noted after the operation.
  • [MeSH-major] Appendiceal Neoplasms / complications. Appendicitis / complications. Hernia, Inguinal / complications
  • [MeSH-minor] Adenocarcinoma / complications. Adenocarcinoma / surgery. Appendectomy. Colectomy. Humans. Male. Middle Aged

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  • (PMID = 19756915.001).
  • [ISSN] 1248-9204
  • [Journal-full-title] Hernia : the journal of hernias and abdominal wall surgery
  • [ISO-abbreviation] Hernia
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] Adenocarcinoid tumor
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50. Suzuki O, Ono K, Sekishita Y, Fujimori M, Shiono T, Kondo S: Laparoscopic two-stage surgery for goblet cell carcinoid of the appendix: report of a case and review of the Japanese literature. Surg Laparosc Endosc Percutan Tech; 2006 Apr;16(2):106-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Laparoscopic two-stage surgery for goblet cell carcinoid of the appendix: report of a case and review of the Japanese literature.
  • Goblet cell carcinoid of the appendix is a rare clinical entity exhibiting features of both carcinoid and adenocarcinoma.
  • A 49-year-old man underwent laparoscopic appendectomy under the diagnosis of acute appendicitis.
  • A pathologic diagnosis of goblet cell carcinoid, accompanied by the aggressive proliferation, with acute appendicitis was made.
  • Subsequent laparoscopic ileocecal resection was performed, and it was verified that there were neither residual tumor nor lymph node metastases.
  • [MeSH-major] Appendectomy / methods. Appendiceal Neoplasms / surgery. Carcinoid Tumor / surgery. Colectomy / methods. Laparoscopy / methods
  • [MeSH-minor] Anastomosis, Surgical / methods. Diagnosis, Differential. Follow-Up Studies. Humans. Male. Middle Aged

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  • (PMID = 16773013.001).
  • [ISSN] 1530-4515
  • [Journal-full-title] Surgical laparoscopy, endoscopy & percutaneous techniques
  • [ISO-abbreviation] Surg Laparosc Endosc Percutan Tech
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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51. Vidarsdottir H, Moller PH, Benediktsdottir KR, Geirsson G: Adenocarcinoma of the appendix with a fistula to the urinary bladder. Scand J Urol Nephrol; 2010 Nov;44(5):354-6
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  • [Title] Adenocarcinoma of the appendix with a fistula to the urinary bladder.
  • Adenocarcinoma of the vermiform appendix is a rare disease that constitutes less than 0.5% of all gastrointestinal malignancies.
  • She was diagnosed with adenocarcinoma of the appendix with a fistula to the urinary bladder.
  • [MeSH-major] Adenocarcinoma / complications. Appendiceal Neoplasms / complications. Urinary Fistula / etiology

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  • (PMID = 20509819.001).
  • [ISSN] 1651-2065
  • [Journal-full-title] Scandinavian journal of urology and nephrology
  • [ISO-abbreviation] Scand. J. Urol. Nephrol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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52. Kobayashi T, Kawahara H, Koido S, Kobayashi S, Kashiwagi H, Yanaga K: Significance of thymidine phosphorylase expression in stromal cells around invasive front of rectal cancer. Hepatogastroenterology; 2008 Nov-Dec;55(88):2045-8
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  • [Title] Significance of thymidine phosphorylase expression in stromal cells around invasive front of rectal cancer.
  • METHODOLOGY: This study was conducted on 95 patients with T2 (n=34) or T3 (n=61) rectal cancer for whom curative surgical resection was performed between 1998 and 2002.
  • As a control, appendix vermiform of twenty patients excised for acute appendicitis during the same period was analyzed.
  • TP expressions in the stromal cells in the appendix with inflammation were also very high, which was detectable both in the nucleus as well as in the cytoplasm.
  • [MeSH-major] Adenocarcinoma / enzymology. Rectal Neoplasms / enzymology. Stromal Cells / enzymology. Thymidine Phosphorylase / biosynthesis

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  • (PMID = 19260474.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Vascular Endothelial Growth Factor A; EC 2.4.2.4 / Thymidine Phosphorylase
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53. Farah-Klibi F, Kourda-Boujemaa J, Bouaskar I, Dziri C, Rachida Z, Jilani-Baltagi SB: Cystadenocarcinoma of the appendix: an incidental perioperatory finding in a patient with adenocarcinoma of the ascending and sigmoid colon: case report and review of literature. Pathologica; 2009 Dec;101(6):255-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cystadenocarcinoma of the appendix: an incidental perioperatory finding in a patient with adenocarcinoma of the ascending and sigmoid colon: case report and review of literature.
  • BACKGROUND: Primary adenocarcinomas of the appendix are uncommon, constituting 1% of all colorectal malignancies.
  • Appendiceal malignancies often present atypically, thus creating diagnostic challenges.
  • Although there are many pathology reports of primary cystadenocarcinoma of the appendix, only a limited number of cases have appeared in the radiological or surgical literature.
  • We present a unique case of primary cystadenocarcinoma of the appendix occurring concurrently with adenocarcinoma of the colon, and overview the clinical and therapeutic difficulties posed by this rare entity.
  • CASE PRESENTATION: A mucocele of the appendix, due to mucinous cystadenocarcinoma, was documented as an incidental perioperatory finding in a 68-year-old female.
  • Degenerated adenomatous polyp of the ascending colon and mucinous adenocarcinoma of the sigmoid colon invading the parietal peritoneum of the uterine and vagina was diagnosed.
  • At laparoscopy, a cystic appendiceal lesion was found, without perforation.
  • CONCLUSIONS: Preoperative diagnosis of an underlying malignancy in a mucocele is important for patient management, but is difficult to reach by imaging studies alone.
  • Synchronous colon cancer may occur in patients with appendiceal mucoceles.
  • [MeSH-major] Adenocarcinoma / pathology. Appendiceal Neoplasms / pathology. Colonic Neoplasms / pathology. Cystadenocarcinoma / pathology. Neoplasms, Multiple Primary / pathology

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  • (PMID = 20387715.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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54. Young RH: From krukenberg to today: the ever present problems posed by metastatic tumors in the ovary: part I. Historical perspective, general principles, mucinous tumors including the krukenberg tumor. Adv Anat Pathol; 2006 Sep;13(5):205-27
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Scully that ovarian mucinous tumors in patients with pseudomyxoma peritonei usually originate from the appendix is correct.
  • The final portion of the essay reviews mucinous tumors of non-Krukenberg type, beginning with those that originate from the appendix.
  • The appendiceal neoplasms have distinctive features in most cases being particularly well differentiated, and this is also seen in their ovarian metastases.
  • [MeSH-minor] Adenocarcinoma, Mucinous / secondary. Appendiceal Neoplasms / pathology. Diagnosis, Differential. Female. History, 20th Century. Humans. Pancreatic Neoplasms / pathology. Periodicals as Topic / history

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  • (PMID = 16998315.001).
  • [ISSN] 1072-4109
  • [Journal-full-title] Advances in anatomic pathology
  • [ISO-abbreviation] Adv Anat Pathol
  • [Language] eng
  • [Publication-type] Historical Article; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 70
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55. Waku T: [A study on nine cases of mucocele of the appendix]. Nihon Shokakibyo Gakkai Zasshi; 2008 Feb;105(2):214-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A study on nine cases of mucocele of the appendix].
  • A clinicopathological study was made on 9 cases of mucocele (8 cases of adenoma and 1 case of adenocarcinoma) of the appendix treated at the hospital in the recent 12 years.
  • With abdominal CT, correct preoperative diagnosis was successfully made in 7 out of 9 cases of mucocele of the appendix.
  • Two cases of mucocele of the appendix were diagnosed as peritoneal pseudomyxoma before surgery.
  • The most common operative procedure was ileocecal resection in 4 cases including 2 cases undergone irrigation of the abdominal cavity, and partial cecectomy in 5 cases including 2 cases undergone irrigation in the abdominal cavity.
  • For a patient with adenocarcinoma, we repeated intraperitoneal chemotherapy with cisplatin after surgery.
  • Eight patients with adenoma are doing well, but one patient with adenocarcinoma died 48 months after surgery.
  • [MeSH-major] Appendix. Cecal Diseases / diagnosis. Mucocele / diagnosis
  • [MeSH-minor] Aged. Aged, 80 and over. Appendiceal Neoplasms / diagnosis. Appendiceal Neoplasms / surgery. Female. Humans. Male. Middle Aged

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  • (PMID = 18250592.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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56. O'Brien GC, Nzewi E, Deasy J: Mucinous neoplasm of the appendix with elevated carcinoembryonic antigen. Ir Med J; 2005 Sep;98(8):240-1
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  • [Title] Mucinous neoplasm of the appendix with elevated carcinoembryonic antigen.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Appendiceal Neoplasms / pathology

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  • (PMID = 16255116.001).
  • [ISSN] 0332-3102
  • [Journal-full-title] Irish medical journal
  • [ISO-abbreviation] Ir Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen
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57. Shah VB, Amonkar GP, Deshpande JR, Bhalekar H: Mucinous adenocarcinoma of the renal pelvis with pseudomyxoma peritonei. Indian J Pathol Microbiol; 2008 Oct-Dec;51(4):536-7
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  • [Title] Mucinous adenocarcinoma of the renal pelvis with pseudomyxoma peritonei.
  • Mucinous adenocarcinoma of the renal pelvis is an extremely rare tumor with very few case reports in literature.
  • It occurs secondary to primary mucinous neoplasms of particularly the appendix and the ovary.
  • Thus, a diagnosis of mucinous adenocarcinoma of the renal pelvis leading to pseudomyxoma peritonei was made.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Kidney Neoplasms / pathology. Kidney Pelvis / pathology. Neoplasms, Multiple Primary / pathology. Peritoneal Neoplasms / pathology. Pseudomyxoma Peritonei / pathology

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  • (PMID = 19008588.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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58. Miyakura Y, Iwai H, Togashi K, Horie H, Nagai H, Kishaba Y, Sato K, Azuma H: Mucinous cystadenocarcinoma of the appendix invading the ascending colon with fistula formation: report of a case. Surg Today; 2007;37(9):806-10
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  • [Title] Mucinous cystadenocarcinoma of the appendix invading the ascending colon with fistula formation: report of a case.
  • Based on colonoscopy findings, we made a preoperative diagnosis of primary mucinous cystadenocarcinoma of the appendix with features of a submucosal tumor (SMT) in the ascending colon.
  • Examination of colonoscopic biopsy specimens indicated "very" well-differentiated adenocarcinoma with mucus lakes.
  • The adjacent appendix had an enhanced wall and unclear border against the ascending colon.
  • Histopathological examination revealed mucinous cystadenocarcinoma of the appendix, invading the ascending colon with fistula formation.
  • Appendiceal tumors can manifest with a variety of colonoscopic features, and curative surgical resection should be attempted even if there is fistula formation.
  • [MeSH-major] Appendix / pathology. Colon / pathology. Colonic Diseases / etiology. Cystadenocarcinoma, Mucinous / complications. Intestinal Fistula / etiology. Mucins

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  • [Cites] Gastrointest Endosc. 2005 Sep;62(3):452-6 [16111974.001]
  • [Cites] J Clin Pathol. 1994 Oct;47(10):880-5 [7962600.001]
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  • (PMID = 17713739.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Mucins
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59. Stamatakos M, Stefanaki Ch, Tsaknaki S, Safioleas P, Iannescu R, Safioleas M: Primary adenocarcinoma of the appendix: an update. Chirurgia (Bucur); 2009 Jul-Aug;104(4):389-92
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  • [Title] Primary adenocarcinoma of the appendix: an update.
  • Adenocarcinoid arising in the vermiform appendix is a rarity.
  • The diagnosis of appendiceal adenocarcinoma has never been made preoperatively and is frequently an incidental finding at the time of operation for unrelated conditions.
  • [MeSH-major] Adenocarcinoma. Appendectomy. Appendiceal Neoplasms
  • [MeSH-minor] Carcinoid Tumor / diagnosis. Carcinoid Tumor / epidemiology. Carcinoid Tumor / surgery. Humans. Incidental Findings. Prognosis. Treatment Outcome

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  • (PMID = 19886044.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
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60. Daniels JA, Lederman HM, Maitra A, Montgomery EA: Gastrointestinal tract pathology in patients with common variable immunodeficiency (CVID): a clinicopathologic study and review. Am J Surg Pathol; 2007 Dec;31(12):1800-12
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  • Age at diagnosis ranged from 6 months to 62 years (median, 35.5 y), and age at biopsy ranged from 10 months to 67 years (median, 38 y).
  • Gastric adenocarcinoma was identified in one patient.
  • The appendix from 1 patient showed Cryptosporidium and acute serositis with a paucity of plasma cells and an increase in apoptosis.
  • In fact, in our series, we found patients with a prior diagnosis of celiac disease (25%) and inflammatory bowel disease (35%), including Crohn disease (15%).
  • The diagnosis of CVID may be suspected on the basis of the lack of plasma cells in a GI biopsy, but because this feature is only present in about two-thirds of patients, the diagnosis cannot always be suggested in isolation of other clinical and laboratory findings.
  • [MeSH-minor] Adolescent. Adult. Aged. Celiac Disease / pathology. Child. Child, Preschool. Colitis, Collagenous / pathology. Colitis, Lymphocytic / pathology. Diagnosis, Differential. Female. Granulomatous Disease, Chronic / pathology. Humans. Infant. Inflammatory Bowel Diseases / pathology. Male. Middle Aged

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  • (PMID = 18043034.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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61. Mizuta Y, Akazawa Y, Shiozawa K, Ohara H, Ohba K, Ohnita K, Isomoto H, Takeshima F, Omagari K, Tanaka K, Yasutake T, Nakagoe T, Shirono K, Kohno S: Pseudomyxoma peritonei accompanied by intraductal papillary mucinous neoplasm of the pancreas. Pancreatology; 2005;5(4-5):470-4
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  • No primary tumour, including mucinous neoplasm of the appendix, was found.
  • Histopathological examination of the omentum showed mucinous adenocarcinoma in pools of mucoid material, consistent with PMP.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Adenocarcinoma, Papillary / pathology. Carcinoma, Pancreatic Ductal / pathology. Pancreatic Neoplasms / pathology. Peritoneal Neoplasms / pathology. Pseudomyxoma Peritonei / pathology
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Ascites / pathology. Chemotherapy, Cancer, Regional Perfusion. Cisplatin / administration & dosage. Deoxycytidine / analogs & derivatives. Etoposide / administration & dosage. Humans. Hyperthermia, Induced. Infusions, Parenteral. Male. Middle Aged. Mitomycin / administration & dosage. Neoplasms, Multiple Primary

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  • [Copyright] Copyright 2005 S. Karger AG, Basel and IAP.
  • (PMID = 15983445.001).
  • [ISSN] 1424-3903
  • [Journal-full-title] Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
  • [ISO-abbreviation] Pancreatology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0W860991D6 / Deoxycytidine; 50SG953SK6 / Mitomycin; 6PLQ3CP4P3 / Etoposide; B76N6SBZ8R / gemcitabine; Q20Q21Q62J / Cisplatin
  • [Number-of-references] 19
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62. Osborne CL, Boulind CE, Cooper E, Francis NK: Incidental cystadenocarcinoma of the appendix in a patient undergoing laparoscopic right hemicolectomy for caecal cancer: a case report. Cases J; 2009;2:7505
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  • [Title] Incidental cystadenocarcinoma of the appendix in a patient undergoing laparoscopic right hemicolectomy for caecal cancer: a case report.
  • Primary appendiceal neoplasms are rare and usually found incidentally after appendicectomy for suspected appendicitis.
  • We report a case of a perforated cystadenocarcinoma of the appendix occurring synchronously with caecal adenocarcinoma in an 81-year-old woman without abdominal symptoms or signs, who presented with iron deficiency anaemia.

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  • (PMID = 19829982.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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63. Logan-Collins JM, Lowy AM, Robinson-Smith TM, Kumar S, Sussman JJ, James LE, Ahmad SA: VEGF expression predicts survival in patients with peritoneal surface metastases from mucinous adenocarcinoma of the appendix and colon. Ann Surg Oncol; 2008 Mar;15(3):738-44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] VEGF expression predicts survival in patients with peritoneal surface metastases from mucinous adenocarcinoma of the appendix and colon.
  • BACKGROUND: High levels of vascular endothelial growth factor (VEGF) in ovarian cancer metastases are associated with a worse prognosis in patients treated with chemotherapy.
  • VEGF-directed therapy improves survival for those with metastatic colorectal cancer.
  • We hypothesized that angiogenic indices may be prognostic in patients undergoing cytoreductive surgery for mucinous adenocarcinoma of the appendix and colon.
  • CD 34 counts (blood vessels) and VEGF expression was evaluated by means of immunohistochemistry on specimens from patients undergoing cytoreductive surgery and intraperitoneal hyperthermic perfusion (IPHP) for mucinous adenocarcinoma.
  • RESULTS: A total of 26 males and 9 females, with a mean age of 50 years, underwent cytoreductive surgery and IPHP for mucinous adenocarcinoma of appendiceal (n = 32) or colonic (n = 3) origin.
  • CONCLUSIONS: These results suggest that markers of tumor angiogenesis may predict survival in patients with peritoneal surface metastases from mucinous adenocarcinoma.
  • [MeSH-major] Adenocarcinoma, Mucinous / metabolism. Adenocarcinoma, Mucinous / therapy. Appendiceal Neoplasms / pathology. Appendiceal Neoplasms / therapy. Biomarkers, Tumor / biosynthesis. Peritoneal Neoplasms / metabolism. Peritoneal Neoplasms / therapy. Vascular Endothelial Growth Factor A / biosynthesis

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  • (PMID = 18043973.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A
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64. Villanueva Saenz E, Pérez-Aguirre J, Belmonte MC, Martínez PH, Márquez RM, Carranza RJ: Appendix adenocarcinoma associated with ulcerative colitis: a case report and literature review. Tech Coloproctol; 2006 Mar;10(1):54-6
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  • [Title] Appendix adenocarcinoma associated with ulcerative colitis: a case report and literature review.
  • Ulcerative colitis (UC) represents a risk factor for colorectal cancer, but the association between UC and appendix cancer is uncommon.
  • Histopathological analysis indicated adenocarcinoma from the cecal appendix, and chronic-active ulcerative colitis of the colon.
  • The appendix adenocarcinoma and ulcerative colitis may or may not be associated, same as colon cancer in patients with UC.
  • [MeSH-major] Adenocarcinoma / etiology. Appendiceal Neoplasms / etiology. Colitis, Ulcerative / complications


65. Agaimy A, Pelz AF, Wieacker P, Roessner A, Wünsch PH, Schneider-Stock R: Gastrointestinal stromal tumors of the vermiform appendix: clinicopathologic, immunohistochemical, and molecular study of 2 cases with literature review. Hum Pathol; 2008 Aug;39(8):1252-7
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  • [Title] Gastrointestinal stromal tumors of the vermiform appendix: clinicopathologic, immunohistochemical, and molecular study of 2 cases with literature review.
  • Gastrointestinal stromal tumors (GIST) are rare in the vermiform appendix.
  • Here, we report 2 appendiceal gastrointestinal stromal tumors in a 78-year-old woman and a 72-year-old man with a history of endometrial adenocarcinoma and urinary bladder carcinoma, respectively.
  • We suggest that the molecular pathogenesis of appendiceal gastrointestinal stromal tumors beyond initiating KIT mutations might be different from their gastric and intestinal counterparts.
  • The coincidence of loss of p16 and overexpression of human telomerase reverse transcriptase seems to be in contradiction to the small size, the benign nature, and the limited growth potential of appendiceal gastrointestinal stromal tumors.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Gastrointestinal Stromal Tumors / pathology

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  • (PMID = 18547614.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
  • [Number-of-references] 21
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66. Bozanović T, Ljubić A, Momcilov P, Mostić T, Vojvodić L, Vidaković S: Synchronous primary tumors: appendiceal and ovarian cancer--case report. Eur J Gynaecol Oncol; 2009;30(2):237-8
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  • [Title] Synchronous primary tumors: appendiceal and ovarian cancer--case report.
  • A 64-year-old women was operated on for acute abdomen and both appendiceal and ovarian tumors were found.
  • Histology revealed synchronous adenocarcinoma of the appendix and serous pappillary carcinoma of the right ovary.
  • A rare case of synchronous primary tumors of appendiceal and ovarian origin is reported.
  • [MeSH-major] Adenocarcinoma / pathology. Appendiceal Neoplasms / pathology. Carcinoma, Papillary / pathology. Neoplasms, Multiple Primary / pathology. Ovarian Neoplasms / pathology

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  • (PMID = 19480268.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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67. Levy AD, Shaw JC, Sobin LH: Secondary tumors and tumorlike lesions of the peritoneal cavity: imaging features with pathologic correlation. Radiographics; 2009 Mar-Apr;29(2):347-73
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  • However, when low-grade mucinous adenocarcinoma of the appendix spreads to the peritoneal cavity, the consequence is typically pseudomyxoma peritonei, which is a clinical syndrome, characterized by recurrent and recalcitrant voluminous mucinous ascites due to surface growth on the peritoneum without significant invasion of underlying tissues.
  • [MeSH-major] Neoplasms, Mesothelial / diagnosis. Neoplasms, Mesothelial / secondary. Peritoneal Neoplasms / diagnosis. Peritoneal Neoplasms / secondary. Tomography, X-Ray Computed / methods. Ultrasonography / methods

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  • (PMID = 19325052.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 93
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68. Stojanović I, Karamehmedović Z, Elgazwi K, Baća I: Laparoscopic treatment of cystadenocarcinoma of the appendix penetrating in the sigmoid colon. JSLS; 2009 Jul-Sep;13(3):445-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Laparoscopic treatment of cystadenocarcinoma of the appendix penetrating in the sigmoid colon.
  • Adenocarcinoma of the vermiform appendix is a rare neoplasm of the gastrointestinal tract that most commonly presents as right lower abdominal pain, mimicking acute appendicitis.
  • An accurate and complete preoperative diagnosis has been rare in the past; however, modern imaging techniques allow recognition of most complications and associated conditions.
  • The diagnosis is confirmed postoperatively.
  • Aggressive surgical management is the treatment of choice in appendicular adenocarcinoma.

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  • [Cites] Int J Urol. 2001 Apr;8(4):196-8 [11260355.001]
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  • (PMID = 19793493.001).
  • [ISSN] 1086-8089
  • [Journal-full-title] JSLS : Journal of the Society of Laparoendoscopic Surgeons
  • [ISO-abbreviation] JSLS
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
  • [Other-IDs] NLM/ PMC3015953
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69. Chetty R, Klimstra DS, Henson DE, Albores-Saavedra J: Combined classical carcinoid and goblet cell carcinoid tumor: a new morphologic variant of carcinoid tumor of the appendix. Am J Surg Pathol; 2010 Aug;34(8):1163-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Combined classical carcinoid and goblet cell carcinoid tumor: a new morphologic variant of carcinoid tumor of the appendix.
  • Carcinoid tumors are the most common neoplasms of the appendix.
  • In this report, we describe 5 cases of combined classical carcinoid and goblet cell carcinoid (GCC) tumors of the appendix.
  • The tumors (0.6 to 6.0 cm) were located in the mid-portion and the tip of the appendix.
  • All 5 appendiceal tumors had microscopic features of both classical carcinoid and GCC, either intimately admixed or separate but closely apposed.
  • The pelvic soft tissue and ovarian metastases in case 4 consisted predominantly of a signet ring cell carcinoma with a minor component of goblet cells and was interpreted as an adenocarcinoma ex-GCC.
  • In view of the fact that these combined carcinoid tumors appear to behave more as goblet cell carcinoids, detailed microscopic examination of classical carcinoid tumors of the appendix is suggested and larger series with longer follow-up is required to ascertain the true biologic potential of this unique form of combined carcinoid tumor of the appendix.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Carcinoid Tumor / pathology. Goblet Cells / pathology. Mixed Tumor, Malignant / pathology

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  • [CommentIn] Am J Surg Pathol. 2011 Aug;35(8):1248-50 [21753706.001]
  • (PMID = 20631606.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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71. Terada T: Non-invasive Adenocarcinoma of the Vermiform Appendix: Incidence and Report of Four Cases among 512 Appendectomies. Gastroenterology Res; 2009 Aug;2(4):238-241
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Non-invasive Adenocarcinoma of the Vermiform Appendix: Incidence and Report of Four Cases among 512 Appendectomies.
  • : Tumors of the vermiform appendix are relatively rare.
  • More than 50% of appendiceal tumors are carcinoid tumors.
  • The author reviewed 512 consecutive pathological specimens of appendectomies in last ten years in our pathology laboratory in search for appendiceal tumors.
  • As the results, 4 cases (incidence: 0.8%) of non-invasive adenocarcinoma were found.
  • The age of the 4 patients with adenocarcinoma was 48, 39, 84 and 86 years, respectively.
  • Pathologically, all the 4 tumors were non-invasive adenocarcinomas: 2 cases were flat type adenocarcinoma, 1 case was papillary adenocarcinoma, and 1 case was mucinous adenocarcinoma.
  • The results suggest that incidence of appendiceal adenocarcinoma was 0.8% of all appendectomies, and that non-invasive adenocarcinoma of the appendix shows variable morphologies, and that postoperative clinical outcome of non-invasive appendiceal tumor is good.

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  • (PMID = 27942282.001).
  • [ISSN] 1918-2805
  • [Journal-full-title] Gastroenterology research
  • [ISO-abbreviation] Gastroenterology Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Keywords] NOTNLM ; Adenocarcinoma / Appendix / Histopathology / Non-invasive carcinoma / appendicitis
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72. Graham RP, Williams NP, West KA: Primary epithelial tumours of the appendix in a black population: a review of cases. World J Gastroenterol; 2009 Mar 28;15(12):1472-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary epithelial tumours of the appendix in a black population: a review of cases.
  • AIM: To determine the prevalence, histologic types and clinical features of primary epithelial tumours of the vermiform appendix in a predominantly black population.
  • METHODS: All cases of primary tumours of the appendix identified by review of the histopathology records at the University of the West Indies between January 1987 and June 2007 were selected.
  • A clinical diagnosis of acute appendicitis was the most common reason for appendectomy (57.1%) and was histologically confirmed in 75% (18 of 24) of cases.
  • CONCLUSION: Appendiceal epithelial tumours are rare in our experience, and are represented principally by carcinoid tumours and adenomas.
  • [MeSH-major] African Continental Ancestry Group / statistics & numerical data. Appendiceal Neoplasms / epidemiology. Appendiceal Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / epidemiology. Adenocarcinoma / pathology. Adenoma / epidemiology. Adenoma / pathology. Adolescent. Adult. Aged. Aged, 80 and over. Carcinoid Tumor / epidemiology. Carcinoid Tumor / pathology. Female. Humans. Male. Middle Aged. Prevalence. Retrospective Studies. West Indies / epidemiology. Young Adult

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  • [Cites] Cancer. 2003 Feb 15;97(4):934-59 [12569593.001]
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  • (PMID = 19322920.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2665141
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73. Gillion JF, Franco D, Chapuis O, Serpeau D, Convard JP, Jullès MC, Balaton A, Karkouche B, Capelle P, Parmentier T, Chollet JM, Thillois JM, Berthelot G: [Appendiceal mucoceles, pseudomyxoma peritonei and appendiceal mucinous neoplasms: update on the contribution of imaging to choice of surgical approach]. J Chir (Paris); 2009 Apr;146(2):150-66
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Appendiceal mucoceles, pseudomyxoma peritonei and appendiceal mucinous neoplasms: update on the contribution of imaging to choice of surgical approach].
  • [Transliterated title] Mucocèles appendiculaires, pseudomyxomes péritonéaux et tumeurs mucosécrétantes du carrefour iléocaecal: apport de l'imagerie dans la stratégie thérapeutique et le choix de la voie d'abord laparoscopique ou classique.
  • INTRODUCTION: The treatment of pseudomyxoma peritonei (PMPs) and appendiceal mucocele (AM) has changed radically.
  • Eleven patients had an intact AM, seven synchronous PMP (malignant appendiceal lesion in two of seven), six metachronous PMP (five with peritoneal mucinous carcinomatosis and one with diffuse peritoneal adenomucinosis) and three a ruptured AM but not PMP.
  • [MeSH-major] Adenocarcinoma, Mucinous / radiography. Appendiceal Neoplasms / radiography. Appendix / radiography. Mucocele / radiography. Peritoneal Neoplasms / radiography. Pseudomyxoma Peritonei / radiography

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  • [CommentIn] J Chir (Paris). 2009 Apr;146(2):167 [19540495.001]
  • (PMID = 19552906.001).
  • [ISSN] 0021-7697
  • [Journal-full-title] Journal de chirurgie
  • [ISO-abbreviation] J Chir (Paris)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Multicenter Study
  • [Publication-country] France
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74. Benedix F, Reimer A, Gastinger I, Mroczkowski P, Lippert H, Kube R, Study Group Colon/Rectum Carcinoma Primary Tumor: Primary appendiceal carcinoma--epidemiology, surgery and survival: results of a German multi-center study. Eur J Surg Oncol; 2010 Aug;36(8):763-71
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  • [Title] Primary appendiceal carcinoma--epidemiology, surgery and survival: results of a German multi-center study.
  • BACKGROUND: While carcinoma of the colon is a common malignancy, primary carcinoma of the appendix is rare.
  • Many retrospective reviews outlined experience from different centers on appendiceal neoplasms.
  • The aim of this study was to analyze the type of surgery and survival of patients with appendiceal malignancies using data from a German multi-center observational study (31 341 patients).
  • METHODS: During a five-year period, 196 consecutive patients with malignant appendiceal tumors were distributed into four groups: appendiceal carcinoids, adenocarcinoma, mucinous adenocarcinoma and adenosquamous carcinoma.
  • RESULTS: Adenocarcinoma had the highest incidence (50.5%).
  • Metastatic spread at presentation was highest for adenosquamous and mucinous adenocarcinoma and each had a distinct pattern.
  • Among all appendiceal neoplasms, adenosquamous carcinoma is the rarest histological subtype which is most commonly associated with advanced tumor stage and worst prognosis.
  • [MeSH-major] Appendiceal Neoplasms / epidemiology. Appendiceal Neoplasms / surgery. Colectomy
  • [MeSH-minor] Adenocarcinoma / epidemiology. Adenocarcinoma / surgery. Adenocarcinoma, Mucinous / epidemiology. Adenocarcinoma, Mucinous / surgery. Adult. Aged. Appendicitis / diagnosis. Carcinoid Tumor / epidemiology. Carcinoid Tumor / surgery. Carcinoma, Adenosquamous / epidemiology. Carcinoma, Adenosquamous / surgery. Diagnosis, Differential. Female. Germany. Humans. Male. Middle Aged. Neoplasm Staging. Unnecessary Procedures / statistics & numerical data

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  • [Copyright] Copyright (c) 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20561765.001).
  • [ISSN] 1532-2157
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] England
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75. Hsu JT, Chen HM, Liao CH, Yeh CN, Yeh TS, Hwang TL, Jan YY, Chen MF: Clinicopathologic features and predictors for survival of mucinous and non-mucinous appendiceal adenocarcinoma. Dig Surg; 2008;25(5):369-75
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  • [Title] Clinicopathologic features and predictors for survival of mucinous and non-mucinous appendiceal adenocarcinoma.
  • BACKGROUND/AIMS: We report a study in patients with mucinous and non-mucinous appendiceal adenocarcinoma treated surgically whose records were examined to elucidate their clinicopathologic features and prognostic factors for survival.
  • METHODS: The medical records of 34 patients with mucinous and non-mucinous appendiceal adenocarcinoma (1991-2005) were retrospectively reviewed.
  • The overall 5-year survival rate for 34 patients with appendiceal adenocarcinoma was 35.8%.
  • CONCLUSION: Mucinous appendiceal adenocarcinoma had clinicopathologic characteristics and a prognosis similar to non-mucinous, except that there was more leukocytosis in non-mucinous tumors.
  • Tumor stage is an independent predictor for survival among patients with appendiceal adenocarcinoma.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Appendiceal Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Adult. Aged. Aged, 80 and over. Analysis of Variance. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Appendectomy / methods. Biopsy. Chemotherapy, Adjuvant. Female. Follow-Up Studies. Humans. Male. Medical Records. Middle Aged. Multivariate Analysis. Neoplasm Staging. Postoperative Care. Predictive Value of Tests. Prognosis. Retrospective Studies. Risk Factors. Survival Analysis

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  • (PMID = 19005255.001).
  • [ISSN] 1421-9883
  • [Journal-full-title] Digestive surgery
  • [ISO-abbreviation] Dig Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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76. Bucher P, Gervaz P, Ris F, Oulhaci W, Egger JF, Morel P: Surgical treatment of appendiceal adenocarcinoid (goblet cell carcinoid). World J Surg; 2005 Nov;29(11):1436-9
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  • [Title] Surgical treatment of appendiceal adenocarcinoid (goblet cell carcinoid).
  • Adenocarcinoid of the appendix is an infrequent tumor with histologic features of both adenocarcinoma and carcinoid tumor.
  • The aim of this study was to analyze long-term results of surgical treatment for appendiceal adenocarcinoid.
  • A retrospective review (1991-2003) identified seven patients (median age 72, range 27-81 years) treated for appendiceal adenocarcinoid.
  • Our results suggest that appendectomy alone could be used for appendiceal adenocarcinoid provided that the tumor (1) is less than 1 cm;.
  • (2) does not extend beyond the appendix adventitia;.
  • The risk for developing colorectal adenocarcinoma seems to be extremely high in patients treated for appendiceal adenocarcinoid and warrants close follow-up with colonoscopic screening.
  • [MeSH-major] Appendectomy. Appendiceal Neoplasms / surgery. Carcinoid Tumor / surgery

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  • (PMID = 16136284.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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77. Alsaad KO, Serra S, Schmitt A, Perren A, Chetty R: Cytokeratins 7 and 20 immunoexpression profile in goblet cell and classical carcinoids of appendix. Endocr Pathol; 2007;18(1):16-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytokeratins 7 and 20 immunoexpression profile in goblet cell and classical carcinoids of appendix.
  • Goblet cell carcinoid (GCC) of the vermiform appendix is an uncommon neoplasm and its histogenesis is controversial.
  • Whether GCC represents a morphological variant of classical appendiceal carcinoid or a mucin-producing adenocarcinoma is still conjectural.
  • Little is known about the immunohistochemical expression of cytokeratins 7 (CK7) and 20 (CK20) in appendiceal neuroendocrine tumors.
  • In this study, we compared the expression of CK7 and CK20 in 17 cases of appendiceal GCC and 25 cases of classical carcinoid.
  • The tumors were also evaluated for Ki-67 proliferation index, mitotic activity, tumor necrosis, extracellular pools of mucin, obvious intestinal type adenocarcinomatous foci, angiolymphatic permeation, perineural/neural infiltration, and the depth of invasion of the appendix wall.
  • In addition, GCC shows the same CK7/CK20 immunoexpression as colorectal adenocarcinoma.
  • [MeSH-major] Appendiceal Neoplasms / metabolism. Carcinoid Tumor / metabolism. Goblet Cells / metabolism. Keratin-20 / metabolism. Keratin-7 / metabolism

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  • (PMID = 17652796.001).
  • [ISSN] 1046-3976
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Keratin-20; 0 / Keratin-7; 0 / Ki-67 Antigen
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78. Ahmad J, Andrabi SI, Thekkinkattil DK, Rathore MA: Adenocarcinoid tumour of the appendix masquerading as acute appendicitis: a word of caution. Ulus Travma Acil Cerrahi Derg; 2008 Apr;14(2):167-9
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  • [Title] Adenocarcinoid tumour of the appendix masquerading as acute appendicitis: a word of caution.
  • Adenocarcinoids are rare and aggressive tumors with histological features of both carcinoid tumor and adenocarcinoma.
  • We report a case of a 32-year-old man with diffuse infiltration of the appendix wall and mesoappendix by an adenocarcinoid.
  • We suggest that patients with diffuse appendiceal involvement require an aggressive surgical therapy and follow-up.
  • [MeSH-major] Appendiceal Neoplasms / diagnosis. Carcinoid Tumor / diagnosis
  • [MeSH-minor] Adult. Appendicitis / diagnosis. Diagnosis, Differential. Humans. Male. Tomography, X-Ray Computed

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  • (PMID = 18523911.001).
  • [ISSN] 1306-696X
  • [Journal-full-title] Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES
  • [ISO-abbreviation] Ulus Travma Acil Cerrahi Derg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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79. Liu L, Sun L, Wang J, Ji G, Chen B, Zhang H: Ovarian cystadenocarcinoma and pseudomyxoma peritonei. BMJ Case Rep; 2010;2010
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  • Localised pseudomyxoma peritonei associated with adenocarcinoma of the right ovary was diagnosed.
  • The patient underwent resection of the ovary, uterus, uterine tube and appendix with excision of the mesenteric lymph nodes and removal of about 5000 ml of yellowish mucoid jelly.
  • [MeSH-minor] Biomarkers, Tumor / analysis. Diagnosis, Differential. Diagnostic Imaging. Female. Humans. Lymph Node Excision. Middle Aged

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  • (PMID = 22753161.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC3029120
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80. Woei Chung L, Liao YM, Hsieh CY, Lin CY: Oxaliplatin-induced long QT syndrome in a patient with appendiceal adenocarcinoma. Acta Oncol; 2009;48(1):156-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Oxaliplatin-induced long QT syndrome in a patient with appendiceal adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / drug therapy. Appendiceal Neoplasms / drug therapy. Long QT Syndrome / chemically induced. Organoplatinum Compounds / adverse effects

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  • (PMID = 18618340.001).
  • [ISSN] 1651-226X
  • [Journal-full-title] Acta oncologica (Stockholm, Sweden)
  • [ISO-abbreviation] Acta Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Norway
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; 04ZR38536J / oxaliplatin; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil
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81. Maes M, Segers K, Cheyns P: Goblet cell carcinoid of the appendix: laparoscopic appendectomy or right hemicolectomy? Acta Chir Belg; 2008 Jul-Aug;108(4):447-50
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  • [Title] Goblet cell carcinoid of the appendix: laparoscopic appendectomy or right hemicolectomy?
  • Goblet cell carcinoids are uncommon tumours with histological features of both adenocarcinoma and carcinoid tumour.
  • They occur predominantly in the appendix and although the malignant potential remains unclear, adenocarcinoids appear to be more aggressive than conventional carcinoids.
  • Macroscopically, a diffusely inflamed appendix was found with no sign of perforation.
  • As they may present the same clinical presentation, pathological diagnosis is required to distinguish goblet cell carcinoid from acute appendicitis.
  • Two-stage surgery for goblet cell carcinoid is advocated in the literature, but the debate still continues as to whether the goblet cell carcinoid should be treated by appendectomy alone, as for most carcinoids, or by right hemicolectomy, as for the appendiceal adenocarcinoma.
  • [MeSH-major] Appendectomy / methods. Appendiceal Neoplasms / surgery. Carcinoid Tumor / surgery. Colectomy / methods. Laparoscopy / methods
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Follow-Up Studies. Humans

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  • (PMID = 18807600.001).
  • [ISSN] 0001-5458
  • [Journal-full-title] Acta chirurgica Belgica
  • [ISO-abbreviation] Acta Chir. Belg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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82. Suzuki J, Kazama S, Kitayama J, Uozaki H, Miyata T, Nagawa H: Signet ring cell carcinoma of the appendix manifesting as colonic obstruction and ovarian tumors: report of a case. Surg Today; 2009;39(3):235-40
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  • [Title] Signet ring cell carcinoma of the appendix manifesting as colonic obstruction and ovarian tumors: report of a case.
  • Appendiceal cancer is rare and associated with a poor prognosis because it is usually found at an advanced stage.
  • We report a case of appendiceal adenocarcinoma manifesting as a colonic obstruction with a lower abdominal mass.
  • Laparotomy revealed bilateral ovarian tumors and a small appendiceal tumor with peritoneal metastases.
  • We performed ileocecal resection, colectomy, and oophorectomy, following which a histological diagnosis of signet ring cell carcinoma was made.
  • Immunohistochemical analysis revealed positive expression of cytokeratin 7 and 20, and mucin core protein 2 (MUC2), compatible with appendiceal cancer and Kruckenberg metastases.
  • When a patient is found to have disseminated pelvic signet ring cell carcinoma of unknown origin, the appendix should be considered as a possible primary site.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Carcinoma, Signet Ring Cell / pathology. Intestinal Obstruction / etiology. Ovarian Neoplasms / pathology
  • [MeSH-minor] Aged. Biomarkers / analysis. Female. Humans. Magnetic Resonance Imaging. Peritoneal Neoplasms / diagnosis. Peritoneal Neoplasms / secondary. Peritoneal Neoplasms / surgery. Tomography, X-Ray Computed


83. McGory ML, Maggard MA, Kang H, O'Connell JB, Ko CY: Malignancies of the appendix: beyond case series reports. Dis Colon Rectum; 2005 Dec;48(12):2264-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignancies of the appendix: beyond case series reports.
  • PURPOSE: A comprehensive analysis was performed for five histologic types of appendiceal tumors to compare incidence, clinicopathologic features, survival, and appropriateness of surgery.
  • METHODS: All patients diagnosed with mucinous adenocarcinoma (n = 951), adenocarcinoma (n = 646), carcinoid (n = 435), goblet (n = 369), and signet-ring cell (n = 113) in the Surveillance, Epidemiology, and End Results database (1973-2001) were analyzed.
  • RESULTS: Tumor incidence, patient demographics, survival outcomes, and appropriateness of surgery varied significantly among the different appendiceal tumor histologies.
  • The most common appendiceal tumors were mucinous.
  • CONCLUSIONS: This study provides a population-based analysis of epidemiology, tumor characteristics, survival, and quality of care for appendiceal carcinomas.
  • This characterization provides a novel description of the presentation and outcomes for malignancies of the appendix and highlights that a substantial number of patients with appendiceal tumors may not be receiving appropriate surgical resection.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Appendiceal Neoplasms / pathology. Carcinoid Tumor / pathology. Carcinoma, Signet Ring Cell / pathology

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  • (PMID = 16258711.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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84. Graziani R, Brandalise A, Bellotti M, Manfredi R, Contro A, Falconi M, Boninsegna L, Pozzi Mucelli R: Imaging of neuroendocrine gastroenteropancreatic tumours. Radiol Med; 2010 Oct;115(7):1047-64
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  • Radiological detection of carcinoid tumours is limited by typical tumour location throughout the gastrointestinal tract or appendix and is therefore dependent on the tumour being large enough to make it recognisable in that site.
  • Rather, its role is to characterise the tumour and, in particular, to differentiate pancreatic NFET from ductal adenocarcinoma, as in comparison, malignant NFETs have a more favourable prognosis (5-year survival rate 40% compared with 3%-5% for adenocarcinoma) and therefore require different treatment approaches.
  • [MeSH-major] Intestinal Neoplasms / diagnosis. Neuroendocrine Tumors / diagnosis. Pancreatic Neoplasms / diagnostic imaging. Stomach Neoplasms / diagnosis

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  • (PMID = 20221711.001).
  • [ISSN] 1826-6983
  • [Journal-full-title] La Radiologia medica
  • [ISO-abbreviation] Radiol Med
  • [Language] eng; ita
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
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85. van Huisseling H, van Hanegem L, van Dijk M: Post-menopausal vaginal bleeding caused by carcinoma of the appendix: a case report. J Med Case Rep; 2010;4:127
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  • [Title] Post-menopausal vaginal bleeding caused by carcinoma of the appendix: a case report.
  • The most frequent malignancy found in cases of post-menopausal bleeding is endometrial cancer.
  • To the best of our knowledge, it appears that this is the first published case of a post-menopausal primary appendiceal carcinoma presenting with vaginal blood loss.
  • Microscopic examination of the tissue removed at laparotomy revealed an adenocarcinoma of the appendix.

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  • (PMID = 20433768.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2873455
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86. Velusamy A, Saw S, Gossage J, Bailey S, Schofield J: Combined adenocarcinoid and mucinous cystadenoma of the appendix: a case report. J Med Case Rep; 2009;3:28
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  • [Title] Combined adenocarcinoid and mucinous cystadenoma of the appendix: a case report.
  • INTRODUCTION: Adenocarcinoid of the appendix is a rare malignant tumour with features of both adenocarcinoma and carcinoid, showing both epithelial and endocrine differentiation.
  • Mucinous cystadenoma is the commonest of the benign neoplasms of the appendix, with an incidence of 0.6% in appendicectomy specimens.
  • Laparoscopy revealed an adenocarcinoid of the appendix in combination with mucinous cystadenoma.
  • CONCLUSION: Adenocarcinoids account for 2% of primary appendiceal malignancies.

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  • (PMID = 19171048.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2647933
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87. Katsuno G, Kagawa S, Kokudo Y, Muraoka A, Tatemoto A, Sone Y, Tsumura M, Tsuruno M, Mizobuchi K: Ureteral metastasis from appendiceal cancer: report of a case. Surg Today; 2005;35(2):168-71
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  • [Title] Ureteral metastasis from appendiceal cancer: report of a case.
  • We report a case of primary appendiceal cancer that metastasized to the ureter.
  • After a detailed examination she was diagnosed to have cancer of the appendix, multiple liver metastases, and left hydronephrosis.
  • Since an obstruction of the ileocecum was obvious, she underwent an ileocecal resection and a resection of the spindle-shaped tumor invading the left ureter.
  • The spindle-shaped tumor was considered to be due to invasion of the appendiceal cancer to the left ureter.
  • [MeSH-major] Adenocarcinoma / pathology. Appendiceal Neoplasms / pathology. Ureteral Neoplasms / secondary

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  • (PMID = 15674503.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 15
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88. Coursey CA, Nelson RC, Moreno RD, Dodd LG, Patel MB, Vaslef S: Carcinoid tumors of the appendix: are these tumors identifiable prospectively on preoperative CT? Am Surg; 2010 Mar;76(3):273-5
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  • [Title] Carcinoid tumors of the appendix: are these tumors identifiable prospectively on preoperative CT?
  • The purpose of this study was to determine if carcinoid tumors of the appendix were identified prospectively on preoperative CT at our institution during the last decade.
  • A surgical database search performed using the Current Procedural Terminology codes for appendectomy and colectomy yielded 2108 patients who underwent appendectomy or colectomy with removal of the appendix from January 1998 through September 2007.
  • Pathology reports were reviewed to identify patients in whom an appendiceal carcinoid tumor was identified.
  • Carcinoid tumors occurred in 1.1 per cent of appendix specimens.
  • [MeSH-major] Appendiceal Neoplasms / radiography. Carcinoid Tumor / radiography. Tomography, X-Ray Computed
  • [MeSH-minor] Adenocarcinoma / epidemiology. Adenocarcinoma / surgery. Adult. Aged. Aged, 80 and over. Female. Humans. Incidental Findings. Intestinal Neoplasms / epidemiology. Intestinal Neoplasms / surgery. Male. Middle Aged. Neoplasms, Multiple Primary / surgery. Preoperative Period. Young Adult

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  • (PMID = 20349655.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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89. Barry M, Collins CG, McCawley N, McGuinness J, Leahy AL: Synchronous appendiceal tumours. Surgeon; 2007 Apr;5(2):111-3
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  • [Title] Synchronous appendiceal tumours.
  • Primary appendiceal neoplasms are a rare clinical and pathological entity.
  • We report a case of synchronous appendiceal tumours of different histological types which presented as a symptomatic palpable and radiologically apparent mass in the right iliac fossa.
  • This case demonstrates the importance of pre-operative diagnosis of these neoplasms, as it may alter the surgical approach and obviate the need for additional surgery.
  • Furthermore, some of the controversies associated with the management of an appendix mass in the elderly population are discussed.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Appendiceal Neoplasms / pathology. Carcinoid Tumor / pathology. Neoplasms, Multiple Primary / pathology

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  • (PMID = 17450695.001).
  • [ISSN] 1479-666X
  • [Journal-full-title] The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
  • [ISO-abbreviation] Surgeon
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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90. Feo CF, Porcu A, Scanu AM, Ginesu GC, Fancellu A, Lorettu A, Dettori G: Primary appendiceal tumors: report on 10 cases. Int Surg; 2009 Jul-Sep;94(3):224-7
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  • [Title] Primary appendiceal tumors: report on 10 cases.
  • We report our experience on 10 patients with primary tumors of the appendix treated at our institution from 1998 to 2005.
  • Two of the four patients with benign tumors died from causes unrelated to the appendiceal neoplasm.
  • Despite the rarity of appendiceal primary tumors, surgeons should be aware of these neoplasms for making correct treatment decisions.
  • We stress the importance of laparoscopic exploration in the management of appendiceal masses.
  • [MeSH-major] Adenocarcinoma / surgery. Appendiceal Neoplasms / surgery. Carcinoid Tumor / surgery

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  • (PMID = 20187516.001).
  • [ISSN] 0020-8868
  • [Journal-full-title] International surgery
  • [ISO-abbreviation] Int Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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91. Hibi K, Mizutani M, Imazawa M, Nakamura T, Nonoyama M, Shibata H: Mucinous cystadenoma of the appendix associated with muscular and neuromatous hyperplasia: report of a case. Nagoya J Med Sci; 2008 Mar;70(1-2):35-40
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  • [Title] Mucinous cystadenoma of the appendix associated with muscular and neuromatous hyperplasia: report of a case.
  • Mucinous cystadenoma of the appendix is a type of appendiceal mucocele and a rather rare condition usually found incidentally in the course of other abdominal surgery.
  • A previous evaluation of 73 appendiceal mucoceles showed that this disease was often associated with adenocarcinoma and other epithelial atypia.
  • This observation suggested that patients with mucinous cystadenoma of the appendix also have some underlying disorders.
  • However, non-epithelial changes associated with appendiceal mucocele have not been reported so far.
  • In this study, we presented for the first time a mucinous cystadenoma of the appendix associated with muscular and neuromatous hyperplasia.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Cystadenoma, Mucinous / pathology. Muscle, Smooth / pathology

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  • (PMID = 18807294.001).
  • [ISSN] 0027-7622
  • [Journal-full-title] Nagoya journal of medical science
  • [ISO-abbreviation] Nagoya J Med Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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92. Ratanarapee S, Nualyong C: Acute appendicitis as primary symptom of prostatic adenocarcinoma: report of a case. J Med Assoc Thai; 2010 Nov;93(11):1327-31
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  • [Title] Acute appendicitis as primary symptom of prostatic adenocarcinoma: report of a case.
  • The authors reported a 62-year-old Thai man who underwent appendectomy due to classical symptoms and signs of acute appendicitis and was subsequently referred to Siriraj Hospital for proper management after a pathological report of metastatic adenocarcinoma to the appendix.
  • [MeSH-major] Adenocarcinoma / secondary. Appendiceal Neoplasms / secondary. Appendicitis / diagnosis. Prostatic Neoplasms / pathology
  • [MeSH-minor] Appendectomy. Asian Continental Ancestry Group. Biopsy. Diagnosis, Differential. Humans. Male. Middle Aged. Neoplasm Metastasis. Orchiectomy. Prostate-Specific Antigen / blood. Treatment Outcome

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  • (PMID = 21114214.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Thailand
  • [Chemical-registry-number] EC 3.4.21.77 / Prostate-Specific Antigen
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93. Yamaguchi H, Ishimaru M, Suzuki H, Yamashita H, Hatanaka K, Uekusa T, Nagawa H: Isolated abdominal wound recurrence after lymph-node dissection for appendiceal adenocarcinoma. Am J Surg; 2010 Jan;199(1):e7-9
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  • [Title] Isolated abdominal wound recurrence after lymph-node dissection for appendiceal adenocarcinoma.
  • Postoperative histology revealed a moderately differentiated adenocarcinoma in the appendix that invaded the submucosa along with lymphatic involvement.
  • Forty-three days later, an ileocecal resection with radical lymph node dissection was performed through a midline incision.
  • Three of the 30 resected lymph nodes were found to have adenocarcinoma metastasis.
  • [MeSH-major] Abdominal Wall / pathology. Adenocarcinoma / secondary. Adenocarcinoma / surgery. Appendiceal Neoplasms / surgery. Lymph Nodes / surgery. Neoplasm Recurrence, Local / pathology
  • [MeSH-minor] Abdominal Pain / diagnosis. Abdominal Pain / etiology. Appendectomy / methods. Cicatrix / pathology. Follow-Up Studies. Humans. Immunohistochemistry. Lymph Node Excision / methods. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. Reoperation. Risk Assessment. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 19837396.001).
  • [ISSN] 1879-1883
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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94. Lansdale N, Dagash H, Cohen M, Walker J: An ovarian tumour with a potential appendiceal origin. Pediatr Surg Int; 2008 Feb;24(2):245-7
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  • [Title] An ovarian tumour with a potential appendiceal origin.
  • The appendix was histologically normal.
  • It is known to occur simultaneously with tumours of the appendix.
  • Paediatric surgeons need to be aware of this rare tumour and when operating on any ovarian pathology should always inspect the peritoneal cavity for mucinous deposits and examine the appendix.
  • [MeSH-major] Adenocarcinoma, Mucinous / surgery. Appendiceal Neoplasms / surgery. Ovarian Neoplasms / surgery
  • [MeSH-minor] Adolescent. Appendectomy. Diagnosis, Differential. Female. Humans. Laparoscopy

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  • [Cites] Mod Pathol. 2005 Feb;18 Suppl 2:S33-50 [15761465.001]
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  • (PMID = 17401568.001).
  • [ISSN] 0179-0358
  • [Journal-full-title] Pediatric surgery international
  • [ISO-abbreviation] Pediatr. Surg. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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95. Innis M, Sandiford N, Shenoy RK, Prussia PR, Zbar A: Carcinoma of the jejunum with multideposit peritoneal seeding, resection and intraperitoneal chemotherapy. West Indian Med J; 2005 Sep;54(4):242-6
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  • Jejunal adenocarcinoma is rare, often presenting late with widespread intraperitoneal disease.
  • Intraperitoneal chemotherapy (IPC) has been shown in non-randomized studies to improve the survival of patients presenting with intraperitoneal metastases from carcinoma of the colon, appendix and stomach and in primary peritoneal malignancies including mesothelioma and pseudomyxoma peritonei, providing that adequate operative cytoreduction can be performed.
  • A case is presented of obstructive jejunal adenocarcinoma in which 19 intraperitoneal deposits were excised.
  • [MeSH-major] Adenocarcinoma / drug therapy. Adenocarcinoma / surgery. Antineoplastic Combined Chemotherapy Protocols. Jejunal Neoplasms / drug therapy. Jejunal Neoplasms / surgery. Peritoneal Neoplasms / drug therapy. Peritoneal Neoplasms / surgery

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  • (PMID = 16312191.001).
  • [ISSN] 0043-3144
  • [Journal-full-title] The West Indian medical journal
  • [ISO-abbreviation] West Indian Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Jamaica
  • [Chemical-registry-number] Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil
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96. Gungor T, Altinkaya O, Ozat M, Sirvan L, Yalcin H, Mollamahmutoglu L: Primary adenocarcinoid tumor of the ovary arising in mature cystic teratoma. A case report. Eur J Gynaecol Oncol; 2009;30(1):110-2
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  • Examination of the resected lymphatic, omental and appendiceal tissue indicated no tumoral invasion.
  • Thus, the diagnosis was primary ovarian carcinoid arising from a mature cystic teratoma.
  • This case, in the setting of a normal appendix and negative workup for an extraovarian origin, is one of a primary ovarian adenocarcinoid tumor.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Carcinoid Tumor / pathology. Neoplasms, Second Primary. Ovarian Neoplasms / pathology. Teratoma / pathology


97. Umemoto M, Shiota M, Shimaoka M, Hoshiai H: Definitive diagnosis of primary adenocarcinoma of the appendix by laparoscopic appendectomy. J Obstet Gynaecol Res; 2007 Aug;33(4):590-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Definitive diagnosis of primary adenocarcinoma of the appendix by laparoscopic appendectomy.
  • We report a 62-year-old woman with a primary adenocarcinoma of the appendix mimicking ovarian tumor.
  • However, the present case suggests that, in some cases, if cancer of the appendix can be diagnosed early, laparotomy can be avoided and the cancer treated with minimally invasive laparoscopic surgery alone.
  • [MeSH-major] Adenocarcinoma / pathology. Appendiceal Neoplasms / pathology

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  • (PMID = 17688638.001).
  • [ISSN] 1341-8076
  • [Journal-full-title] The journal of obstetrics and gynaecology research
  • [ISO-abbreviation] J. Obstet. Gynaecol. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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98. Walters KC, Paton BL, Schmelzer TS, Gersin KS, Iannitti DA, Kercher KW, Heniford BT: Treatment of appendiceal adenocarcinoma in the United States: penetration and outcomes of current guidelines. Am Surg; 2008 Nov;74(11):1066-8
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  • [Title] Treatment of appendiceal adenocarcinoma in the United States: penetration and outcomes of current guidelines.
  • Current treatment guidelines for appendiceal adenocarcinoma specify that right hemicolectomy should be performed.
  • This study evaluates appendiceal cancer outcomes in the United States and treatment guideline compliance.
  • Data for patients diagnosed with appendiceal adenocarcinoma in the Surveillance, Epidemiology, and End Results database (1988 to 2003) were analyzed.
  • The 2511 patients with appendiceal adenocarcinoma had an average age of 59.3 years, average tumor size of 4.05 cm, and 5-year survival rate of 57 per cent.
  • One-third of patients with adenocarcinoma did not undergo current surgical guideline therapy.
  • The current data raise the question of whether Stage I and II appendiceal cancer can be adequately treated with simple appendectomy.
  • [MeSH-major] Adenocarcinoma / surgery. Appendectomy. Appendiceal Neoplasms / surgery. Colectomy

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  • (PMID = 19062662.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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99. Shinji A, Mukawa K, Nokubi M, Ohta H, Mochizuki T, Okiyama W, Yamamura N, Oguchi H, Nakamura T, Hamano H: Missed appendiceal adenocarcinoma diagnosed preoperatively by endoscopy with an attached transparent hood. Gastrointest Endosc; 2009 Mar;69(3 Pt 2):761-2; discussion 762
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Missed appendiceal adenocarcinoma diagnosed preoperatively by endoscopy with an attached transparent hood.
  • [MeSH-major] Adenocarcinoma / diagnosis. Appendiceal Neoplasms / diagnosis. Endoscopy, Gastrointestinal

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  • (PMID = 19251025.001).
  • [ISSN] 1097-6779
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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100. Djuranovic SP, Spuran MM, Kovacevic NV, Ugljesic MB, Kecmanovic DM, Micev MT: Mucinous cystadenoma of the appendix associated with adenocarcinoma of the sigmoid colon and hepatocellular carcinoma of the liver: report of a case. World J Gastroenterol; 2006 Mar 28;12(12):1975-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mucinous cystadenoma of the appendix associated with adenocarcinoma of the sigmoid colon and hepatocellular carcinoma of the liver: report of a case.
  • Mucinous cystadenoma of the appendix is a rare condition and represents one of the three entities with the common name mucocele of the appendix.
  • This condition is often associated with other neoplasia, especially adenocarcinoma of the colon and ovaries.
  • He had a big cystadenoma of the appendix associated with adenocarcinoma of the colon and hepatocellular carcinoma of the liver.
  • According to this, we stress the need of accurate preoperative diagnosis and intraoperative exploration of the whole abdomen in these patients.
  • [MeSH-major] Adenocarcinoma / complications. Appendiceal Neoplasms / complications. Carcinoma, Hepatocellular / complications. Cystadenoma, Mucinous / complications. Liver Neoplasms / complications. Sigmoid Neoplasms / complications

  • MedlinePlus Health Information. consumer health - Liver Cancer.
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  • (PMID = 16610012.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4087531
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