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1. Terada T: Endometriosis of the Vermiform Appendix Presenting as a Tumor. Gastroenterology Res; 2009 Dec;2(6):353-355
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Endometriosis of the Vermiform Appendix Presenting as a Tumor.
  • : Endometriosis of the vermiform appendix is a rare condition.
  • Most patients with this disease are asymptomatic or present as acute or chronic appendicitis.
  • The author herein reports a case of appendiceal endometriosis presenting as a tumor at the appendiceal oriffice.
  • A colon endoscopy showed a tumor in the appendiceal orifice.
  • Two biopsies of the tumor showed no remarkable changes.
  • Imaging modalities including CT and MRI also revealed an appendiceal tumor.
  • Resection of appendix, cecum, ascending colon, terminal ileum, and 16 lymph nodes were performed under the clinical diagnosis of gastrointestinal stromal tumor.
  • Grossly, a tumor measuring 3 x 3 x 3 cm was recognized in the appendiceral orifice.
  • Histologically, the tumor was endometriosis consisting of islands of endometrial glands and stroma.
  • The present case suggests that appendiceal endometriosis may present as a tumor.

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  • (PMID = 27990206.001).
  • [ISSN] 1918-2805
  • [Journal-full-title] Gastroenterology research
  • [ISO-abbreviation] Gastroenterology Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Keywords] NOTNLM ; Appendix / Endometriosis / Lymph nodes
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2. Gilboa Y, Fridman E, Ofir K, Achiron R: Carcinoid tumor of the appendix: ultrasound findings in early pregnancy. Ultrasound Obstet Gynecol; 2008 May;31(5):576-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Carcinoid tumor of the appendix: ultrasound findings in early pregnancy.
  • Ultrasound examination of a woman in early pregnancy with right lower quadrant abdominal pain demonstrated an edematous appendix with amorphous fluid surrounding the appendix.
  • On pathological evaluation following surgical removal of the appendix a rare case of carcinoid tumor of the appendix was diagnosed.
  • This is the first description of the transvaginal ultrasound features of a carcinoid tumor of the appendix.
  • [MeSH-major] Appendiceal Neoplasms / ultrasonography. Carcinoid Tumor / ultrasonography. Pregnancy Complications, Neoplastic / ultrasonography

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  • [Copyright] Copyright (c) 2008 ISUOG
  • (PMID = 18393270.001).
  • [ISSN] 1469-0705
  • [Journal-full-title] Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
  • [ISO-abbreviation] Ultrasound Obstet Gynecol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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3. Neves GR, Chapchap P, Sredni ST, Viana CR, Mendes WL: Childhood carcinoid tumors: description of a case series in a Brazilian cancer center. Sao Paulo Med J; 2006 Jan 5;124(1):21-5
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  • [Title] Childhood carcinoid tumors: description of a case series in a Brazilian cancer center.
  • CONTEXT AND OBJECTIVE: Carcinoid tumors are very rare both in children and adults.
  • About 85% of these tumors develop in the gastrointestinal tract.
  • The objective of the present study was to describe our experience with children treated of carcinoid tumors, and investigate the frequency morphological findings and results.
  • DESIGN AND SETTING: Report on case series, at the Department of Pediatrics of Centro de Tratamento e Pesquisa Hospital do Câncer, São Paulo.
  • METHODS: This was a retrospective analysis of clinical pathological data and outcomes among children (< 18 years old) with carcinoid tumors admitted from January 1, 1990, to December 31, 2001.
  • In eight cases (89%), the primary tumor site was the appendix and in one (11%) it was the left bronchus.
  • For those with primary tumor in the appendix, the main complaint was abdominal pain, which led to appendectomy.
  • Only one patient underwent right hemicolectomy due to tumor extension into the serosa.
  • The patient with bronchial tumor underwent left pneumonectomy.
  • All patients had localized disease and are alive and free of disease.
  • CONCLUSION: Although the majority of carcinoid tumors arise from the appendix, these tumors can also occur in other primary sites.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Carcinoid Tumor / pathology
  • [MeSH-minor] Adolescent. Brazil. Child. Child, Preschool. Female. Follow-Up Studies. Humans. Immunohistochemistry. Male. Neoplasm Invasiveness. Retrospective Studies. Sex Factors

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  • (PMID = 16612458.001).
  • [ISSN] 1516-3180
  • [Journal-full-title] São Paulo medical journal = Revista paulista de medicina
  • [ISO-abbreviation] Sao Paulo Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
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4. Chen HT, Lee YT, Chou AS, Wu YK, Yin WY, Lee MC, Hsu YH: Primary appendiceal malignancy: a clinicopathologic study. Kaohsiung J Med Sci; 2006 Dec;22(12):618-25

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  • [Title] Primary appendiceal malignancy: a clinicopathologic study.
  • Primary appendiceal cancer is a rare neoplasm.
  • We analyzed the clinicopathologic characteristics and clinical outcomes of patients with primary appendiceal cancer treated at Buddhist Tzu Chi General Hospital in Eastern Taiwan.
  • We reviewed the medical records of patients who had appendectomy at our hospital over a 10-year period and studied those who had histologically proven malignant appendiceal neoplasms.
  • No patient was diagnosed correctly before surgery, and five (62.5%) had a preoperative diagnosis of acute appendicitis.
  • The important prognostic factors of primary appendiceal cancer included histologic subtypes and the extent of dissemination.
  • [MeSH-major] Appendiceal Neoplasms / pathology

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  • (PMID = 17116623.001).
  • [ISSN] 1607-551X
  • [Journal-full-title] The Kaohsiung journal of medical sciences
  • [ISO-abbreviation] Kaohsiung J. Med. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China (Republic : 1949- )
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5. Coşkun H, Bostanci O, Dilege ME, Mihmanli M, Yilmaz B, Akgün I, Yildirim S: Carcinoid tumors of appendix: treatment and outcome. Ulus Travma Acil Cerrahi Derg; 2006 Apr;12(2):150-4
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  • [Title] Carcinoid tumors of appendix: treatment and outcome.
  • BACKGROUND: The aim of this study is to evaluate the clinical and histopathological features and the treatment of carcinoid tumors of the appendix.
  • METHODS: A retrospective review of medical records and pathology specimens of patients with carcinoid tumor of the appendix has been done.
  • RESULTS: The histopathological examination of the appendices revealed carcinoid tumor in 11 out of 6777 (0.16%) patients operated for acute appendicitis.
  • The tumor was localized in the distal 1/3 region in 10 patients and in the proximal 1/3 region in 1 patient.
  • The mean tumor diameter was 0.73+/-0.36 cm (0.3-1.5).
  • Ten patients had classical type carcinoid tumor whereas goblet cell carcinoid tumor was only seen in one patient.
  • CONCLUSION: In tumors with a diameter of 1 to 2 cm, appendectomy is the treatment of choice.
  • No recurrence was detected with tumors smaller than 2 cm with simple appendectomy.
  • [MeSH-major] Appendiceal Neoplasms / epidemiology. Appendiceal Neoplasms / surgery. Carcinoid Tumor / epidemiology. Carcinoid Tumor / surgery

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  • (PMID = 16676255.001).
  • [ISSN] 1306-696X
  • [Journal-full-title] Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES
  • [ISO-abbreviation] Ulus Travma Acil Cerrahi Derg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Turkey
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6. Tchana-Sato V, Detry O, Polus M, Thiry A, Detroz B, Maweja S, Hamoir E, Defechereux T, Coimbra C, De Roover A, Meurisse M, Honoré P: Carcinoid tumor of the appendix: a consecutive series from 1237 appendectomies. World J Gastroenterol; 2006 Nov 7;12(41):6699-701
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  • [Title] Carcinoid tumor of the appendix: a consecutive series from 1237 appendectomies.
  • AIM: To report the experience of the CHU Sart Tilman, University of Liege, Belgium, in the management of appendiceal carinoid tumor.
  • RESULTS: Among the 1237 appendectomies, 5 appendiceal carcinoid tumors were identified (0.4%) in 4 male and 1 female patients, with a mean age of 29.2 years (range: 6-82 years).
  • All tumors were located at the tip of the appendix with a mean diameter of 0.6 cm (range: 0.3-1.0 cm).
  • All patients were alive and disease-free during a mean follow-up of 33 mo.
  • CONCLUSION: Appendiceal carcinoid tumor most often presents as appendicitis.
  • In most cases, it is found incidentally during appendectomies and its diagnosis is rarely suspected before histological examination.
  • Appendiceal carcinoid tumor can be managed by simple appendectomy and resection of the mesoappendix, if its size is <or=1 cm.
  • [MeSH-major] Appendectomy / methods. Appendiceal Neoplasms / surgery. Carcinoid Tumor / surgery

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  • (PMID = 17075987.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 29
  • [Other-IDs] NLM/ PMC4125679
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7. Christianakis E, Paschalidis N, Chorti M, Filippou G, Rizos S, Filippou D: Carcinoid tumour of the appendix in children: a case report. Cases J; 2008;1(1):136

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Carcinoid tumour of the appendix in children: a case report.
  • Carcinoids are the most common tumours of the appendix.
  • The clinical presentation of the appendiceal carcinoids is similar to that of acute appendicitis, although in many cases the tumour is diagnosed incidentally during an operation.
  • The diagnosis should be confirmed histologically.
  • The prognosis in patients with local disease is excellent.
  • We report a case of a carcinoid tumour in the tip of the appendix of a thirteen year old girl which was diagnosed intraoperatively.
  • Ten years after the operation there is no evidence of recurrence or metastases, and the patient is considered free of disease.

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  • (PMID = 18761734.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2546371
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8. Dall'Igna P, Ferrari A, Luzzatto C, Bisogno G, Casanova M, Alaggio R, Terenziani M, Cecchetto G: Carcinoid tumor of the appendix in childhood: the experience of two Italian institutions. J Pediatr Gastroenterol Nutr; 2005 Feb;40(2):216-9
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  • [Title] Carcinoid tumor of the appendix in childhood: the experience of two Italian institutions.
  • OBJECTIVES: Although rare, carcinoid tumor of the appendix is the most common neoplasm of the gastrointestinal tract in children and adolescents.
  • It is usually an incidental finding after a laparotomy for appendectomy, with a frequency of 2 to 5 cases per 1000 appendectomies.
  • The experience with 14 cases of carcinoid reported in the appendix is described.
  • METHODS AND RESULTS: In six patients the tumor measured 1 cm or less; only in one patient did it measure 2 cm.
  • In three patients the tumor measured between 1 and 2 cm and in four the size was not known.
  • All tumors were discovered by chance, and three patients underwent further surgery as a result of suspected involvement of the margins.
  • All the patients were alive with no evidence of disease at 24 to 214 months from diagnosis.
  • In our experience, both patients with local invasiveness and the patient with a tumor larger than 2 cm had good outcomes.
  • Ileocolectomy performed in the patient with a 2-cm tumor and in another two patients with smaller tumors did not demonstrate residual disease.
  • Although the need for right hemicolectomy still remains controversial for tumors measuring more than 2 cm, the approach may be nonaggressive in case of tumors invading the serosa and the periappendiceal fat.
  • Nonaggressive treatment has been suggested by some authors in cases of tumors larger than 2 cm; however, larger series need to be evaluated.
  • [MeSH-major] Appendectomy. Appendiceal Neoplasms / diagnosis. Carcinoid Tumor / diagnosis
  • [MeSH-minor] Adolescent. Child. Colectomy / methods. Female. Humans. Ileus / surgery. Male. Neoplasm Invasiveness. Neoplasm Recurrence, Local / epidemiology. Prognosis. Treatment Outcome

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  • (PMID = 15699700.001).
  • [ISSN] 0277-2116
  • [Journal-full-title] Journal of pediatric gastroenterology and nutrition
  • [ISO-abbreviation] J. Pediatr. Gastroenterol. Nutr.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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9. Wu CL, Yu CC: Amyand's hernia with adenocarcinoid tumor. Hernia; 2010 Aug;14(4):423-5
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  • [Title] Amyand's hernia with adenocarcinoid tumor.
  • Also, neoplasms of the appendix is quite uncommon.
  • Adenocarcinoid tumor of the appendix was noted after the operation.
  • [MeSH-major] Appendiceal Neoplasms / complications. Appendicitis / complications. Hernia, Inguinal / complications

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  • (PMID = 19756915.001).
  • [ISSN] 1248-9204
  • [Journal-full-title] Hernia : the journal of hernias and abdominal wall surgery
  • [ISO-abbreviation] Hernia
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] Adenocarcinoid tumor
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10. Tang LH: Epithelial neoplasms of the appendix. Arch Pathol Lab Med; 2010 Nov;134(11):1612-20
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  • [Title] Epithelial neoplasms of the appendix.
  • CONTEXT: The appendix gives rise to an array of epithelial neoplasms showing glandular or neuroendocrine differentiation, and some tumors with elements of both cell types.
  • Although some appendiceal neoplasms resemble their counterparts in the small and large intestines (conventional adenocarcinoma and carcinoid tumor), the appendix also gives rise to relatively unique entities including mucinous neoplasms and goblet cell carcinoid tumors, which present a challenge in pathologic classification and clinical management.
  • OBJECTIVE: To review clinical and diagnostic issues for 3 pathologic types of epithelial neoplasms of the appendix:.
  • (1) adenocarcinoma, with specific focus on mucinous neoplasm;.
  • (2) goblet cell carcinoid tumor and associated adenocarcinoma; and (3) typical carcinoid tumor.
  • CONCLUSIONS: The most important issue in pathologic assessment of epithelial tumors of the appendix is to understand the clinical implications inherent in the diagnosis.
  • [MeSH-major] Adenocarcinoma / pathology. Appendiceal Neoplasms / pathology. Appendix / pathology. Carcinoid Tumor / pathology

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  • (PMID = 21043814.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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11. Debnath D, Rees J, Myint F: Are we missing diagnostic opportunities in cases of carcinoid tumours of the appendix? Surgeon; 2008 Oct;6(5):266-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Are we missing diagnostic opportunities in cases of carcinoid tumours of the appendix?
  • OBJECTIVE: Carcinoid tumour of appendix is an uncommon condition that can potentially give rise to a variation in management.
  • We aimed to assess the occurrence and mode of presentation of carcinoid tumour of appendix, and any variation of its management.
  • The mean age of patients with carcinoid tumour (41.8 years) was significantly higher than those with non-carcinoid pathology (27.7 years) (p = 0.001).
  • The incidence of female patients was higher than the male amongst the carcinoid tumour group (female/male ratio 2.2).
  • Eight patients as well as their general practitioners (53.3%) were unaware of the diagnosis.
  • CONCLUSIONS: Carcinoid tumour of the appendix remains an incidental diagnosis.
  • There was a wide variation in involving the multidisciplinary team, conveying the diagnosis to patients as well as their general practitioners, and follow-ups.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Appendiceal Neoplasms / surgery. Carcinoid Tumor / pathology. Carcinoid Tumor / surgery

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  • (PMID = 18939372.001).
  • [ISSN] 1479-666X
  • [Journal-full-title] The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
  • [ISO-abbreviation] Surgeon
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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12. Azordegan N, Yazdankhah A, Moghadasian MH: A rare case of coexistence of carcinoid tumor of appendix vermicularis and ileal endometriosis. Arch Gynecol Obstet; 2009 Feb;279(2):183-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A rare case of coexistence of carcinoid tumor of appendix vermicularis and ileal endometriosis.
  • BACKGROUND: Carcinoid tumor is the most common tumor of appendix with overall good prognosis.
  • CASE REPORT: We here report the coexistence of carcinoid tumor of appendix and ileal endometriosis in a 37-year-old nulliparous woman who came to the emergency room with right lower abdominal pain mimicking acute appendicitis.
  • With preoperative suspicion of acute appendicitis, laparatomy was performed and revealed apparently normal looking appendix, along with a nodule in the terminal ileum.
  • Both the appendix and ileal nodule were removed.
  • Histological examinations revealed carcinoid tumor of appendix and ileal endometriosis.
  • CONCLUSION: Many cases of carcinoid tumor of the appendix and ileal endometriosis are diagnosed incidentally.
  • [MeSH-major] Appendiceal Neoplasms / complications. Carcinoid Tumor / complications. Endometriosis / complications. Ileal Diseases / complications
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Prognosis


13. O'Donnell ME, Badger SA, Beattie GC, Carson J, Garstin WI: Malignant neoplasms of the appendix. Int J Colorectal Dis; 2007 Oct;22(10):1239-48

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant neoplasms of the appendix.
  • BACKGROUND: Appendiceal neoplasms, first described in 1882, are still rare, with pre-operative diagnosis invariably difficult.
  • MATERIALS AND METHODS: A retrospective histopathological review of all appendicectomy specimens was completed between April 1994 and December 2003 to identify patients diagnosed with malignant neoplasms.
  • A literature search of the PubMed database was then performed using the medical search headings; appendix, tumour, neoplasm and malignancy.
  • Other appendiceal pathologies were identified after appendicectomies, hemicolectomy and oophorectomy.
  • CONCLUSIONS: From our own experience and a subsequent review of the literature, we recommend right hemicolectomy as the treatment of choice for all malignant appendiceal neoplasms, except for small CCT less than 2 cm in diameter at the tip of the appendix, with a low proliferative index, without angiolymphatic or mesoappendiceal extension.
  • [MeSH-major] Appendiceal Neoplasms / diagnosis. Appendiceal Neoplasms / therapy

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  • (PMID = 17447078.001).
  • [ISSN] 0179-1958
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article; Meta-Analysis
  • [Publication-country] Germany
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14. Miyazaki K, Satoh H, Sekizawa K: Metastasis to appendix from lung adenocarcinoma. Int J Gastrointest Cancer; 2005;36(1):59-60
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  • [Title] Metastasis to appendix from lung adenocarcinoma.
  • Endoscopic evaluation revealed no obstruction, but failed to identify mucosal abnormalities in the ileocecal region.
  • He underwent a laparotomy, and tumor of the appendix, 3 x 3 cm in diameter, adhered to the surrounding tissue, but no perforation was seen.
  • The mass was excised in combination with an ileocecal resection, followed by ileocolic anastomosis.
  • Hisotologically, the neoplastic tumor cells infiltrated the submucosa, muscularis, and serosa, but mucosa of the appendix was intact, unremarkable, with no precursor lesion.
  • The tumor was morphologically similar to the lung primary tumor.
  • He was examined at regular periodic follow-ups, but died from lung cancer 12 mo after the resection of the metastatic tumor to the appendix.
  • [MeSH-major] Appendiceal Neoplasms / secondary. Lung Neoplasms / pathology

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  • [CommentOn] Int J Gastrointest Cancer. 2003;34(1):55-8 [15235136.001]
  • (PMID = 16227637.001).
  • [ISSN] 1537-3649
  • [Journal-full-title] International journal of gastrointestinal cancer
  • [ISO-abbreviation] Int J Gastrointest Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Comment; Journal Article
  • [Publication-country] United States
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15. Godfrey GJ, Bakkar R, Farghaly H: Mature cystic teratoma of the appendix: a case report. Anal Quant Cytol Histol; 2010 Oct;32(5):295-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mature cystic teratoma of the appendix: a case report.
  • BACKGROUND: Teratomas very rarely arise from the appendix.
  • To our knowledge, only one prior case of mature teratoma involving the appendix has been reported in the medical literature.
  • CASE: Our case is the second reported case of mature cystic teratoma involving the appendix, and, to our knowledge, it is the first reported in a female who had two simultaneous teratomas, one arising from the appendix and one arising from the right ovary.
  • CONCLUSION: Although mature cystic teratoma is a rare tumor of the appendix, it should be considered in the differential diagnosis of appendiceal masses.
  • The differential diagnosis of appendiceal masses, including clinical and pathologic features, is discussed in detail.

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  • (PMID = 22043506.001).
  • [ISSN] 0884-6812
  • [Journal-full-title] Analytical and quantitative cytology and histology
  • [ISO-abbreviation] Anal. Quant. Cytol. Histol.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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16. Goere D, Elias D: [Appendiceal tumors found at appendectomy]. J Chir (Paris); 2009 Oct;146 Spec No 1:36-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Appendiceal tumors found at appendectomy].
  • [Transliterated title] Diagnostic de tumeur appendiculaire lors d'une appendicectomie.
  • There are three main histologic types of appendiceal tumor: adenoma, adenocarcinoma, and neuroendocrine tumor.
  • Neuroendocrine tumors (carcinoids) are by far the most common and account for two-third of all appendiceal tumors.
  • Rupture of any mucinous tumor-whether spontaneous or occurring during surgery-may result in pseudomyxoma peritonei; treatment of this condition requires complete resection of all lesions followed by hyperthermic intraperitoneal chemotherapy.
  • For unruptured appendiceal tumor, the appendix should be removed by a carcinologic right hemicolectomy if the tumor appears aggressive.
  • [MeSH-major] Appendectomy. Appendiceal Neoplasms / surgery
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / surgery. Adenoma / diagnosis. Adenoma / surgery. Humans. Neuroendocrine Tumors / diagnosis. Neuroendocrine Tumors / surgery. Peritoneal Neoplasms / prevention & control. Pseudomyxoma Peritonei / prevention & control. Rupture / prevention & control

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  • (PMID = 19846099.001).
  • [ISSN] 0021-7697
  • [Journal-full-title] Journal de chirurgie
  • [ISO-abbreviation] J Chir (Paris)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 7
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17. Korkontzelos I, Papanicolaou S, Tsimoyiannis I, Kitsiou E, Stefos T, Tsanadis G, Antoniou N: Large carcinoid tumor of the appendix during pregnancy. Eur J Obstet Gynecol Reprod Biol; 2005 Feb 1;118(2):255-7
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  • [Title] Large carcinoid tumor of the appendix during pregnancy.
  • Diagnosis of acute appendicitis is considered more difficult in pregnant than in non-pregnant women.
  • The appendicial carcinoid tumor is a lesion that most frequently is discovered incidentally in the removed organ.
  • We report a rare case of an unruptured acute appendicitis during pregnancy, which proved to be a large carcinoid tumor.
  • [MeSH-major] Appendiceal Neoplasms / diagnosis. Carcinoid Tumor / diagnosis. Pregnancy Complications, Neoplastic

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  • (PMID = 15653215.001).
  • [ISSN] 0301-2115
  • [Journal-full-title] European journal of obstetrics, gynecology, and reproductive biology
  • [ISO-abbreviation] Eur. J. Obstet. Gynecol. Reprod. Biol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Ireland
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18. Pitiakoudis M, Kirmanidis M, Tsaroucha A, Christianakis E, Filippou D, Sivridis E, Simopoulos C: Carcinoid tumor of the appendix during pregnancy. A rare case and a review of the literature. J BUON; 2008 Apr-Jun;13(2):271-5
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  • [Title] Carcinoid tumor of the appendix during pregnancy. A rare case and a review of the literature.
  • We present a rare case of a carcinoid tumor of the appendix that was diagnosed during pregnancy in a 24-year-old female.
  • Only few similar cases were found in the literature reporting appendiceal carcinoid tumor during pregnancy.
  • [MeSH-major] Appendiceal Neoplasms / surgery. Carcinoid Tumor / surgery. Pregnancy Complications, Neoplastic / pathology. Pregnancy Complications, Neoplastic / surgery

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  • (PMID = 18555477.001).
  • [ISSN] 1107-0625
  • [Journal-full-title] Journal of B.U.ON. : official journal of the Balkan Union of Oncology
  • [ISO-abbreviation] J BUON
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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19. Chetty R, Serra S: Lipid-rich and clear cell neuroendocrine tumors ("carcinoids") of the appendix: potential confusion with goblet cell carcinoid. Am J Surg Pathol; 2010 Mar;34(3):401-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Lipid-rich and clear cell neuroendocrine tumors ("carcinoids") of the appendix: potential confusion with goblet cell carcinoid.
  • The so-called clear cell change has been described in neuroendocrine tumors at several locations.
  • Those associated with von Hippel Lindau disease are pathognomonically "clear" and the cytoplasmic appearance has been ascribed to intracytoplasmic lipid.
  • However, lipid has not been demonstrated in all cases of clear cell carcinoid tumors.
  • Such variants have not been described in carcinoid tumors of the appendix and cases with a prominent proportion of clear or more correctly, lipid-rich cytoplasm may bear a superficial resemblance to goblet cell carcinoid and/or signet ring adenocarcinoma.
  • Seven cases, in 5 females and 2 males ranging in age from 22 to 65 years, were noted to have a population of lipid-rich and vacuolated clear cells accounting for 25% or more of the tumor population.
  • The carcinoid tumors were incidental in all cases with 4 of patients presenting with appendicitis, 2 with concomitant mucinous cystadenocarcinomas of the appendix and 1 with an adenocarcinoma of the ascending colon.
  • Morphologically, the tumors had a nested and trabecular pattern and were composed of an admixture of microvesicular and clear lipid-rich cells.
  • None of the patients have shown evidence of recurrent disease.
  • The importance of recognizing this variant of carcinoid tumor in the appendix is to avoid confusion with goblet cell carcinoid tumors with or without a signet ring adenocarcinoma.
  • The presence of multi-vacuolated, foamy and clear cells, some resembling signet ring or goblet cells, in otherwise classic carcinoid tumors is rare but should be considered in this context in the appendix.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Carcinoid Tumor / pathology. Lipids / analysis
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Cytoplasm / chemistry. Cytoplasm / pathology. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Incidental Findings. Male. Middle Aged. Prognosis. Vacuoles / chemistry. Vacuoles / pathology. Young Adult

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  • (PMID = 20139759.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Lipids
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20. Yang WL, Yan CQ, Wang FJ, Wang HL: [Diagnosis and surgical treatment of carcinoid tumors of the appendix in 64 patients]. Zhonghua Zhong Liu Za Zhi; 2008 Jul;30(7):538-40
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  • [Title] [Diagnosis and surgical treatment of carcinoid tumors of the appendix in 64 patients].
  • OBJECTIVE: To summarize the experience in the diagnosis and surgical treatment of carcinoid tumors of the appendix.
  • METHODS: From 1972 to 2006, 64 patients with carcinoid tumors of the appendix received surgical treatment in our hospitals.
  • The operation modes were determined according to the doctor's judgments based on the age of the patients, the nature, size, location, infiltration depth and lymph node metastasis of the tumors.
  • CONCLUSION: Carcinoid tumor of the appendix is rare with a high rate of misdiagnosis before operation.
  • Surgical resection is the only effective treatment for this disease and proper operation mode is the key to achieve good survival.
  • [MeSH-major] Appendiceal Neoplasms / diagnosis. Appendiceal Neoplasms / surgery. Carcinoid Tumor / diagnosis. Carcinoid Tumor / surgery. Diagnostic Errors
  • [MeSH-minor] Adolescent. Adult. Aged. Appendectomy. Colectomy / methods. Female. Follow-Up Studies. Humans. Liver Neoplasms / secondary. Lymph Node Excision. Lymphatic Metastasis. Male. Middle Aged. Retrospective Studies. Survival Rate. Young Adult

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  • (PMID = 19062724.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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21. Chetty R, Klimstra DS, Henson DE, Albores-Saavedra J: Combined classical carcinoid and goblet cell carcinoid tumor: a new morphologic variant of carcinoid tumor of the appendix. Am J Surg Pathol; 2010 Aug;34(8):1163-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Combined classical carcinoid and goblet cell carcinoid tumor: a new morphologic variant of carcinoid tumor of the appendix.
  • Carcinoid tumors are the most common neoplasms of the appendix.
  • Goblet cell carcinoid has been regarded as a distinctive tumor type, not related to classic carcinoids, and to our knowledge combinations of these 2 tumor types have not been described in detail.
  • In this report, we describe 5 cases of combined classical carcinoid and goblet cell carcinoid (GCC) tumors of the appendix.
  • Four men and 1 woman, (mean age 53.4 y) presented with acute appendicitis (4 cases), whereas 1 presented with a pelvic mass owing to widespread pelvic disseminated disease.
  • The tumors (0.6 to 6.0 cm) were located in the mid-portion and the tip of the appendix.
  • Four patients are alive and asymptomatic, whereas the patient with disseminated pelvic disease died 6 months after surgery.
  • All 5 appendiceal tumors had microscopic features of both classical carcinoid and GCC, either intimately admixed or separate but closely apposed.
  • The extent of the 2 components varied, with classical carcinoid representing 60% to 90% of the tumor.
  • In view of the fact that these combined carcinoid tumors appear to behave more as goblet cell carcinoids, detailed microscopic examination of classical carcinoid tumors of the appendix is suggested and larger series with longer follow-up is required to ascertain the true biologic potential of this unique form of combined carcinoid tumor of the appendix.
  • The occurrence of both carcinoid types in the same appendices suggests a closer histogenetic relationship than previously believed, although the possibility that the 2 components represent separate, independent primaries ("collision tumors") can also be considered.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Carcinoid Tumor / pathology. Goblet Cells / pathology. Mixed Tumor, Malignant / pathology
  • [MeSH-minor] Appendectomy. Biomarkers, Tumor / analysis. Colectomy. Female. Humans. Immunohistochemistry. Male. Middle Aged. Mitotic Index. Neoplasm Invasiveness. Treatment Outcome

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  • [CommentIn] Am J Surg Pathol. 2011 Aug;35(8):1248-50 [21753706.001]
  • (PMID = 20631606.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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22. Sugarbaker PH, Bijelic L, Chang D, Yoo D: Neoadjuvant FOLFOX chemotherapy in 34 consecutive patients with mucinous peritoneal carcinomatosis of appendiceal origin. J Surg Oncol; 2010 Nov 1;102(6):576-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Neoadjuvant FOLFOX chemotherapy in 34 consecutive patients with mucinous peritoneal carcinomatosis of appendiceal origin.
  • BACKGROUND: A treatment option for patients with peritoneal mucinous carcinomatosis (PMCA) from an appendiceal neoplasm is cytoreductive surgery and perioperative intraperitoneal chemotherapy.
  • METHODS: In January of 2005 a prospective study was initiated to routinely treat patients with peritoneal dissemination of a mucinous adenocarcinoma of the appendix with neoadjuvant chemotherapy using FOLFOX.
  • In the clinical evaluation and CT evaluation, 24 (71%) and 22 (65%), respectively, had stable disease on chemotherapy.
  • [MeSH-major] Adenocarcinoma, Mucinous / drug therapy. Adenocarcinoma, Mucinous / secondary. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Appendiceal Neoplasms / pathology. Peritoneal Neoplasms / drug therapy. Peritoneal Neoplasms / secondary

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  • (PMID = 20737420.001).
  • [ISSN] 1096-9098
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; Folfox protocol
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23. Feo CF, Porcu A, Scanu AM, Ginesu GC, Fancellu A, Lorettu A, Dettori G: Primary appendiceal tumors: report on 10 cases. Int Surg; 2009 Jul-Sep;94(3):224-7
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  • [Title] Primary appendiceal tumors: report on 10 cases.
  • We report our experience on 10 patients with primary tumors of the appendix treated at our institution from 1998 to 2005.
  • Six tumors were malignant, and the remaining were benign.
  • Two of the four patients with benign tumors died from causes unrelated to the appendiceal neoplasm.
  • The 6 patients with malignant tumors and the other 2 with benign disease were alive and disease free after a mean follow-up of 43 months.
  • Despite the rarity of appendiceal primary tumors, surgeons should be aware of these neoplasms for making correct treatment decisions.
  • We stress the importance of laparoscopic exploration in the management of appendiceal masses.
  • [MeSH-major] Adenocarcinoma / surgery. Appendiceal Neoplasms / surgery. Carcinoid Tumor / surgery

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  • (PMID = 20187516.001).
  • [ISSN] 0020-8868
  • [Journal-full-title] International surgery
  • [ISO-abbreviation] Int Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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24. Lanuke K, Mack LA, Temple WJ: Phase II study of regional treatment for peritoneal carcinomatosis. Am J Surg; 2009 May;197(5):614-8; discussion 618
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  • Patient and tumor characteristics, surgical details, complications, disease-free survival (DFS), and overall survival (OS) were recorded prospectively.
  • RESULTS: The majority (82%) of patients, median age 49 years (range, 18-77 y), had complete macroscopic cytoreduction (completeness of cytoreduction score, 0) despite a generally extensive tumor burden.
  • Preliminary median DFS and OS have not been defined for appendix tumors at a median follow-up period of 16 months (range, 1-86 mo).
  • Median DFS and OS for colonic tumors are 8 months and 26 months, respectively, with a median follow-up period of 12 months (range, 1-48 mo).
  • [MeSH-major] Peritoneal Neoplasms / drug therapy
  • [MeSH-minor] Adolescent. Adult. Aged. Antibiotics, Antineoplastic / administration & dosage. Appendiceal Neoplasms / pathology. Chemotherapy, Cancer, Regional Perfusion. Colorectal Neoplasms / pathology. Disease-Free Survival. Female. Humans. Hyperthermia, Induced. Male. Middle Aged. Mitomycin / administration & dosage. Treatment Outcome. Young Adult

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  • (PMID = 19393354.001).
  • [ISSN] 1879-1883
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 50SG953SK6 / Mitomycin
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25. Elias D, Honoré C, Ciuchendéa R, Billard V, Raynard B, Lo Dico R, Dromain C, Duvillard P, Goéré D: Peritoneal pseudomyxoma: results of a systematic policy of complete cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. Br J Surg; 2008 Sep;95(9):1164-71
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  • BACKGROUND: Pseudomyxoma peritonei (PMP) is characterized by progressive intraperitoneal accumulation of mucous and mucinous implants, usually derived from a ruptured, possibly malignant mucinous neoplasm of the appendix.
  • Overall and disease-free 5-year survival rates were 80.0 and 68.5 per cent respectively.
  • The Cox model identified only two significant factors impacting on disease-free survival: CA19.9 level and pathological grade.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Peritoneal Neoplasms / drug therapy. Peritoneal Neoplasms / surgery. Pseudomyxoma Peritonei / drug therapy. Pseudomyxoma Peritonei / surgery
  • [MeSH-minor] Chemotherapy, Adjuvant / methods. Combined Modality Therapy / methods. Disease-Free Survival. Female. Fluorouracil / administration & dosage. Humans. Hyperthermia, Induced. Injections, Intraperitoneal. Male. Organoplatinum Compounds / administration & dosage. Preoperative Care / methods. Prognosis. Prospective Studies. Treatment Outcome

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  • (PMID = 18690633.001).
  • [ISSN] 1365-2168
  • [Journal-full-title] The British journal of surgery
  • [ISO-abbreviation] Br J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Organoplatinum Compounds; 04ZR38536J / oxaliplatin; U3P01618RT / Fluorouracil
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26. Shinoda M, Hatano S, Kawakubo H, Kakefuda T, Omori T, Ishii S: Adult cecoanal intussusception caused by cecum cancer: report of a case. Surg Today; 2007;37(9):802-5

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  • The defect was moved back to oral side with the pressure of the enema, revealing a tumor originating in the cecum.
  • Laparotomy confirmed that the tumor originated at the bottom of the appendix in the cecum.
  • We performed partial resection of the cecum containing the tumor and appendix.
  • The pathological finding was submucosal adenocarcinoma in adenoma.
  • [MeSH-major] Anal Canal / pathology. Cecal Neoplasms / complications. Cecum / pathology. Intussusception / etiology

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  • (PMID = 17713738.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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27. Young RH: From Krukenberg to today: the ever present problems posed by metastatic tumors in the ovary. Part II. Adv Anat Pathol; 2007 May;14(3):149-77
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  • [Title] From Krukenberg to today: the ever present problems posed by metastatic tumors in the ovary. Part II.
  • This is the second of a two-part consideration of metastatic tumors to the ovary.
  • The first tumor discussed is gastric carcinoma of intestinal-type whose ovarian manifestations have been the subject of a recent paper which emphasized its differences from the Krukenberg tumor.
  • The section on pancreatic neoplasms reemphasizes the problems caused by metastatic ductal carcinoma, considered primarily in Part I, and discusses less common issues such as spread of neuroendocrine and acinar cell carcinomas.
  • The limited information on spread of tumors of the gallbladder and extrahepatic bile ducts is then reviewed before more detailed consideration of hepatic neoplasms, prompted by recent contributions on hepatocellular carcinoma and intrahepatic cholangiocarcinoma, the latter based on significant experience with this problem in Thailand.
  • The section on appendiceal neoplasms highlights ovarian spread of diverse tumors ranging from typical intestinal-type adenocarcinoma to signet-ring cell carcinomas with various patterns which in the ovary may prompt diagnoses such as a goblet cell (mucinous) carcinoid tumor, but whose ovarian features place them in the category of a Krukenberg tumor.
  • The diverse problems in differential diagnosis of carcinoid tumor (provoked by nested, acinar, and other patterns, including folliclelike spaces) are then reviewed.
  • The section on breast cancer emphasizes that, although usually a manifestation of late stage disease and often not bulky in the ovaries, metastatic breast cancer may form large masses which can represent the clinical presentation.
  • The section on lung tumors largely reflects information in a recent paper that small cell carcinoma and adenocarcinoma are the lung cancers that spread to the ovary most commonly.
  • The extremely broad differential diagnosis posed by metastatic malignant melanoma ranging from that of an oxyphilic tumor, to a small cell tumor, to a follicle-forming neoplasm, is then considered.
  • The sections on renal cell carcinoma and other urinary tract neoplasms emphasize the differential diagnosis of metastatic clear cell carcinoma and primary clear cell carcinoma, an issue usually resolvable by an awareness of the various features of the ovarian variant, rarely or never seen in the renal variant.
  • The section on metastatic sarcomas discusses endometrial stromal sarcomas, gastrointestinal stromal neoplasms, and miscellaneous other sarcomas.
  • The endometrial stromal tumors are problematic largely because the history of a primary tumor may be remote, in the ovaries the typical growth and vascular pattern of endometrial stromal neoplasms is not always conspicuous, and some endometrial stromal sarcomas in the ovary show sex cordlike patterns of growth.
  • Recent information has indicated that gastrointestinal stromal tumors may rarely have significant ovarian manifestations and if the primary neoplasm is overlooked, the ovarian tumor may be misdiagnosed, usually as an ovarian fibromatous tumor, but potentially as another primary neoplasm.
  • The final neoplasms considered are malignant mesothelioma and the desmoplastic small round cell tumor.
  • The microscopic features of malignant mesothelioma are so different from those of primary ovarian carcinoma in most instances that the diagnosis should be readily established on routine microscopic evaluation.
  • The differential diagnosis of the desmoplastic small round cell tumor is more complex because of the greater overlap with the many other small cell malignant tumors that may involve the ovaries primarily or secondarily.
  • Nonetheless, differences exist in most cases and awareness of the entity should lead to consideration of the desmoplastic neoplasm, particularly in a young female.
  • However, as pointed out in brief concluding remarks, despite the aid of that modality, as in surgical pathology overall, careful consideration of the clinical background, distribution of disease, gross characteristics and spectrum of routine microscopic findings, will lead to the correct diagnosis in the majority of cases and at the very least lead to formulation of a considered differential diagnosis such that use of special techniques may be judicious and those results placed in context of the time-honored clinical and pathologic features.
  • [MeSH-major] Carcinoma / secondary. Krukenberg Tumor / secondary. Ovarian Neoplasms / secondary
  • [MeSH-minor] Diagnosis, Differential. Female. History, 19th Century. History, 20th Century. Humans

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  • (PMID = 17452813.001).
  • [ISSN] 1072-4109
  • [Journal-full-title] Advances in anatomic pathology
  • [ISO-abbreviation] Adv Anat Pathol
  • [Language] eng
  • [Publication-type] Historical Article; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 67
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28. Safioleas MC, Moulakakis KG, Kontzoglou K, Stamoulis J, Nikou GC, Toubanakis C, Lygidakis NJ: Carcinoid tumors of the appendix. Prognostic factors and evaluation of indications for right hemicolectomy. Hepatogastroenterology; 2005 Jan-Feb;52(61):123-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Carcinoid tumors of the appendix. Prognostic factors and evaluation of indications for right hemicolectomy.
  • BACKGROUND/AIMS: Carcinoid tumors of the appendix are thought to be the most common type of appendiceal neoplasms.
  • Although the vast majority of appendiceal carcinoids behave in a benign fashion, they are considered malignant because they all have the potential for invasion, metastasis and production of physiologically active substances.
  • Following confirmation of the diagnosis, secretion of 5-HLAA (5-Hydroxy-Inndole-Acetic Acid) was measured after a 24-hour collection of urine.
  • Also, patients with tumor size more than 1cm underwent a Somatostatin Receptor Scintigraphy (Octreoscan).
  • RESULTS: The most common site for the tumors was the tip of the appendix (18/22).
  • In the rest of the cases, the neoplasms were located in the base (4/22) and in the body (2/22), while in one patient the mesoappendix was invaded.
  • In sixteen patients the tumor size was less than 1cm, in seven patients the tumor diameter was measured to be 1 to 2cm and in one patient the tumor was 3cm.
  • Most of our patients (16/22) underwent only an appendicectomy, while in the rest of them (in the patients with tumor size between 1-2cm and in the patient with invasion of mesoappendix) a right hemicolectomy was performed.
  • No patient was found to have metastatic disease during the operation, while the patient with invasion of the mesoappendix developed metastases in the lung, two years after the operation.
  • CONCLUSIONS: Carcinoid tumors of the appendix, in most cases, are found incidentally during appendicectomies, especially in young females and usually are less than 1cm in size, which is probably the reason of the absence of metastases in all cases.
  • Histological examination and size of the tumor are important factors that contribute to the selection of the surgical treatment and both must be estimated by the surgeons to make the final choice.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Appendiceal Neoplasms / surgery. Carcinoid Tumor / pathology. Carcinoid Tumor / surgery

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  • (PMID = 15783011.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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29. Murphy EM, Farquharson SM, Moran BJ: Management of an unexpected appendiceal neoplasm. Br J Surg; 2006 Jul;93(7):783-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Management of an unexpected appendiceal neoplasm.
  • BACKGROUND: Appendiceal neoplasms are rare and most present unexpectedly as acute appendicitis.
  • METHODS: A systematic literature review was performed to access relevant publications on the presentation, pathology and management of appendiceal tumours.
  • RESULTS: Appendiceal tumours account for 0.4 to 1 per cent of all gastrointestinal tract malignancies and are found in 0.7 to 1.7 per cent of appendicectomy specimens.
  • Most are cured by simple appendicectomy if the tumour is less than 2 cm in size and does not involve the resection margin or mesoappendix.
  • Epithelial tumours may present with, or in time develop, pseudomyxoma peritonei, the optimal management of which involves complete tumour resection and intraperitoneal chemotherapy, usually available only in specialized centres.
  • CONCLUSION: Suggested algorithms for the management of unexpected appendiceal tumours are provided.
  • Recommendations are made for follow-up of patients with a perforated appendiceal epithelial tumour.
  • [MeSH-major] Appendectomy / methods. Appendiceal Neoplasms / surgery
  • [MeSH-minor] Humans. Incidental Findings. Neoplasm Staging. Treatment Outcome

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  • [Copyright] Copyright 2006 British Journal of Surgery Society Ltd.
  • (PMID = 16775823.001).
  • [ISSN] 0007-1323
  • [Journal-full-title] The British journal of surgery
  • [ISO-abbreviation] Br J Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 94
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30. Low RN, Barone RM, Gurney JM, Muller WD: Mucinous appendiceal neoplasms: preoperative MR staging and classification compared with surgical and histopathologic findings. AJR Am J Roentgenol; 2008 Mar;190(3):656-65
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mucinous appendiceal neoplasms: preoperative MR staging and classification compared with surgical and histopathologic findings.
  • OBJECTIVE: The objective of our study was to determine the accuracy of MRI in the preoperative staging and classification of mucinous appendiceal neoplasms and to describe the MRI features that are useful for selecting patients for surgical resection.
  • Two observers reviewed the images for peritoneal tumor at 13 sites, tumor size and distribution, and degree of tumor enhancement.
  • Peritoneal tumor sites were recorded at surgery.
  • Surgical specimens were classified as disseminated peritoneal adenomucinosis tumors, intermediate-grade tumors, or peritoneal mucinous carcinomatosis tumors.
  • RESULTS: Surgery confirmed 232 tumor sites.
  • MRI findings predicting suboptimal cytoreduction included a large (> 5 cm) mesenteric mass, which was present in 75% of the patients in the suboptimal cytoreduction group and 0% of those in the complete cytoreduction group; diffuse mesenteric tumor (88% and 0%, respectively); tumor encasement of mesenteric vessels (88% and 0%); or diffuse small-bowel serosal tumor (75% and 0%).
  • Histopathology results showed six disseminated peritoneal adenomucinosis tumors, four intermediate tumors, and 11 peritoneal mucinous carcinomatosis tumors.
  • Qualitatively, the 11 peritoneal mucinous carcinomatosis tumors showed greater enhancement than the liver, whereas six disseminated peritoneal adenomucinosis and the four intermediate tumors showed less enhancement than the liver.
  • Quantitatively, the mean tumor-to-liver contrast for disseminated peritoneal adenomucinosis and intermediate tumors was 0.67 compared with 1.53 for peritoneal mucinous carcinomatosis tumors (p < 0.0001).
  • CONCLUSION: Of the MR techniques evaluated, delayed gadolinium-enhanced MRI was the most accurate for the staging and classification of mucinous appendiceal neoplasms and provided prognostic information useful for patient selection.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Magnetic Resonance Imaging. Peritoneal Neoplasms / pathology. Peritoneal Neoplasms / surgery. Pseudomyxoma Peritonei / pathology. Pseudomyxoma Peritonei / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Contrast Media. Female. Gadolinium. Humans. Male. Middle Aged. Neoplasm Staging. Predictive Value of Tests. Retrospective Studies

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  • (PMID = 18287436.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; AU0V1LM3JT / Gadolinium
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31. Sugarbaker PH: Epithelial appendiceal neoplasms. Cancer J; 2009 May-Jun;15(3):225-35

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epithelial appendiceal neoplasms.
  • The appendiceal malignancies usually arise within a mucocele.
  • The tumor within this structure can be minimally aggressive or of an invasive character.
  • If a low-grade appendiceal malignancy is removed intact, recurrence does not occur.
  • If rupture of the wall of the mucocele occurs with either low-grade or high-grade disease, the epithelial cells within will disseminate to the peritoneal surfaces.
  • If the diagnosis of peritoneal dissemination of an appendiceal malignancy has been established, a new treatment with curative intent is indicated.
  • In approximately 900 patients treated at the Washington Cancer Institute, the quantitative prognostic indicators for appendiceal cancer with peritoneal dissemination have been determined.
  • Patients with a complete cytoreduction and low-grade tumor have an 80% survival at 20 years; with high-grade tumors, the survival drops to approximately 45%.
  • The extent of malignancy present within the abdomen by the peritoneal cancer index has a significant impact on survival for both high-grade and low-grade disease.
  • The most important indicator is the completeness of cytoreduction; for both high-grade and low-grade disease, all patients with an incomplete cytoreduction have died by 10 years.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Peritoneal Neoplasms / secondary

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  • (PMID = 19556909.001).
  • [ISSN] 1528-9117
  • [Journal-full-title] Cancer journal (Sudbury, Mass.)
  • [ISO-abbreviation] Cancer J
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 25
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32. Samet I, Cormier B, Mowlawi H, Philippe A, Arbion F, Fétissof F: [Endometrial and endocervical lesions associated with pseudomyxoma peritonei: a case report]. Ann Pathol; 2009 Jun;29(3):233-7
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  • The association of a pseudomyxoma peritonei with a mucinous tumor of the appendix and/or the ovary is regularly reported in the literature.
  • We report the case of a 57-year-old patient, with pseudomyxoma peritonei associated with a low-grade mucinous neoplasia of appendix and both ovaries.
  • Histological and immunohistochemical characteristics of this epithelium were quite comparable to those observed in the appendix and ovaries.
  • The endocervical and endometrial lesions might represent an implantation of mucinous epithelium from appendix, emphasizing the capacity of this epithelium to implant at a distance from the original lesion.
  • [MeSH-major] Adenocarcinoma, Mucinous / complications. Appendiceal Neoplasms / complications. Cervix Uteri / pathology. Endometrium / pathology. Neoplasms, Multiple Primary / pathology. Ovarian Neoplasms / complications. Pseudomyxoma Peritonei / etiology
  • [MeSH-minor] Appendectomy. Breast Neoplasms / diagnosis. Carcinoma, Ductal, Breast / diagnosis. Epithelial Cells / pathology. Female. Humans. Hysterectomy. Metaplasia. Middle Aged. Neoplasm Invasiveness. Ovariectomy


33. Orta L, Trindade AJ, Luo J, Harpaz N: Appendiceal mucinous cystadenoma is a neoplastic complication of IBD: case-control study of primary appendiceal neoplasms. Inflamm Bowel Dis; 2009 Mar;15(3):415-21

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Appendiceal mucinous cystadenoma is a neoplastic complication of IBD: case-control study of primary appendiceal neoplasms.
  • BACKGROUND: IBD is a risk factor for development of colorectal neoplasia.
  • Although IBD frequently involves the appendix microscopically, it is uncertain whether it also predisposes to appendiceal neoplasia.
  • METHODS: We performed a retrospective case-control study of incidental appendiceal neoplasms in colectomy specimens of adults with and without IBD (cases and controls, respectively) based on surgical pathology records spanning 54 months.
  • To minimize referral bias, patients were excluded if they had preoperative clinical evidence or a principal pathologic diagnosis of appendiceal disease.
  • RESULTS: Eleven appendiceal cystadenomas and 6 appendiceal carcinoid tumors were identified among 705 IBD cases (377 ulcerative colitis, 317 Crohn's disease, 11 indeterminate colitis) and 498 non-IBD controls meeting our inclusion criteria.
  • However, cyst adenomas were 15-fold more prevalent among cases with synchronous colorectal neoplasia compared with controls (4/69 [5.8%] versus 2/498 [0.4%], OR 15.3 [95% CI 2.7-85]) and 8-fold higher compared with cases without synchronous neoplasia (4/69 [5.8%] versus 5/636 [0.8%], OR 7.8 [95% CI 2.0-29.6]).
  • Appendiceal carcinoids were equally prevalent in cases and controls (4/705 [0.6%] versus 2/498 [0.4%], OR 1.4 [95% CI 0.3-7.8]), cases with synchronous neoplasia and controls (1/69 [1.4%] versus 2/498 [0.4%], OR 3.6 [95% CI 0.3-40.8]), and cases with and without synchronous colorectal neoplasia (1/69 [1.4%] versus 3/636 [0.5%], OR 3.1 [95% CI 0.3-30.2]).
  • CONCLUSIONS: IBD with synchronous colorectal dysplasia or cancer is a risk factor for development of appendiceal cystadenomas, implicating this tumor as a neoplastic complication of IBD.
  • IBD does not predispose to the development of appendiceal carcinoids.
  • [MeSH-major] Appendiceal Neoplasms / etiology. Cystadenoma, Mucinous / etiology. Inflammatory Bowel Diseases / complications
  • [MeSH-minor] Adult. Aged. Appendectomy. Colectomy. Colonoscopy. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Retrospective Studies. Time Factors. Treatment Outcome

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  • [CommentIn] Inflamm Bowel Dis. 2010 May;16(5):735 [19705419.001]
  • (PMID = 18989894.001).
  • [ISSN] 1536-4844
  • [Journal-full-title] Inflammatory bowel diseases
  • [ISO-abbreviation] Inflamm. Bowel Dis.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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34. Dupre MP, Jadavji I, Matshes E, Urbanski SJ: Diverticular disease of the vermiform appendix: a diagnostic clue to underlying appendiceal neoplasm. Hum Pathol; 2008 Dec;39(12):1823-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diverticular disease of the vermiform appendix: a diagnostic clue to underlying appendiceal neoplasm.
  • Acquired diverticula of the vermiform appendix are rare and arise as a result of different pathogenetic mechanisms.
  • One of the etiologies includes proximally located, often unsuspected small neoplasms.
  • Although the association of appendiceal diverticulosis and neoplasia is known, it remains underemphasized in the teaching and practice of surgical pathology.
  • To investigate the frequency of appendiceal neoplasms with acquired diverticulosis, we conducted a retrospective analysis of all appendectomy specimens received in our institution for a 55-month period (January 2002-July 2006).
  • Eleven (48%) appendectomy specimens with diverticulosis also harbored an appendiceal neoplasm.
  • The association of appendiceal neoplasms with diverticulosis was statistically significant (P < .0001, 2-sided Fisher exact test).
  • Neoplastic processes included 5 well-differentiated neuroendocrine tumors (carcinoids), 3 mucinous adenomas, 1 tubular adenoma, and 2 adenocarcinomas.
  • We stress the need for meticulous gross assessment with histologic examination of the entire appendectomy specimen in cases of appendiceal diverticulosis.
  • Thorough examination is required to rule out an underlying neoplasm as a cause of diverticulosis.
  • As acquired diverticula represent a rare finding, examination of the entire appendix in this setting does not create a significant impact on the workload within the pathologic laboratory.
  • [MeSH-major] Adenocarcinoma / pathology. Appendiceal Neoplasms / pathology. Appendix / pathology. Carcinoid Tumor / pathology. Cystadenoma, Mucinous / pathology. Diverticulum / pathology

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  • (PMID = 18715614.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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35. Yajima N, Wada R, Yamagishi S, Mizukami H, Itabashi C, Yagihashi S: Immunohistochemical expressions of cytokeratins, mucin core proteins, p53, and neuroendocrine cell markers in epithelial neoplasm of appendix. Hum Pathol; 2005 Nov;36(11):1217-25
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistochemical expressions of cytokeratins, mucin core proteins, p53, and neuroendocrine cell markers in epithelial neoplasm of appendix.
  • Epithelial neoplasms of appendix are infrequent, and their pathological features are not fully characterized.
  • We collected 33 cases of appendiceal tumors and examined immunohistochemically the expression of cytokeratins (CK, CK7, and CK20), mucin core protein (MUC1, MUC2, MUC5AC, and MUC6), E-cadherin, chromogranin A, and p53 protein.
  • Clinically, mucinous tumors were predominant in females.
  • Immunohistochemically, all the tumors expressed CK20, whereas CK7 was positive in one third of the cases.
  • Similarly, MUC2 was expressed in all the tumors, whereas MUC1 and MUC5AC were detected in about a half of the cases.
  • Although chromogranin A-positive cells are generally sparse in normal appendix, they were more common in mucinous tumors than in nonmucinous tumors.
  • Contrary to the previous data reported (Mod Pathol 2002;15:599-605), mucinous carcinoma exhibited a higher frequency of p53-positive cells (mean 29%) compared with mucinous adenoma (2.8%) (P < .001), whereas nonmucinous tumors showed high levels of p53-positive cells to similar extent (51%-67%) in both adenoma and carcinoma.
  • The high expression of p53 protein coincided with the presence of mutations in multiple sites of TP53 gene in mucinous tumors.
  • This is the first report that characterized the immunophenotypic profile of appendiceal epithelial neoplasms with an emphasis of a higher frequency of p53 positivity in mucinous carcinoma cases compared with mucinous adenoma in the appendix.
  • [MeSH-major] Appendiceal Neoplasms / metabolism. Biomarkers, Tumor / analysis. Keratins / biosynthesis. Mucins / biosynthesis. Neoplasms, Glandular and Epithelial / metabolism. Tumor Suppressor Protein p53 / biosynthesis


36. O'Donnell ME, Carson J, Garstin WI: Surgical treatment of malignant carcinoid tumours of the appendix. Int J Clin Pract; 2007 Mar;61(3):431-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical treatment of malignant carcinoid tumours of the appendix.
  • Since their first description in 1882, malignant neoplasms of the appendix still remain rare.
  • Malignant carcinoid tumours are the most common accounting for 85% of all appendiceal neoplasms.
  • Preoperative diagnosis is invariably difficult, and precise treatment protocols for these neoplasms remain unclear.
  • Other appendiceal pathologies were identified following hemicolectomy and oophorectomy.
  • However, small CCTs less than 2 cm in diameter at the tip of the appendix, with a low proliferative index, without angiolymphatic or mesoappendiceal extension can be treated by appendicectomy.
  • Following oncological assessment, further adjuvant therapy should be considered for patients with advanced disease.
  • [MeSH-major] Appendectomy / methods. Appendiceal Neoplasms / surgery. Carcinoid Tumor / surgery. Colectomy / methods

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  • (PMID = 16911574.001).
  • [ISSN] 1368-5031
  • [Journal-full-title] International journal of clinical practice
  • [ISO-abbreviation] Int. J. Clin. Pract.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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37. Shapiro JF, Chase JL, Wolff RA, Lambert LA, Mansfield PF, Overman MJ, Ohinata A, Liu J, Wang X, Eng C: Modern systemic chemotherapy in surgically unresectable neoplasms of appendiceal origin: a single-institution experience. Cancer; 2010 Jan 15;116(2):316-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Modern systemic chemotherapy in surgically unresectable neoplasms of appendiceal origin: a single-institution experience.
  • BACKGROUND: Appendiceal neoplasms include tumors ranging from benign-appearing cells with widespread mucin deposits to aggressive poorly differentiated signet ring cell adenocarcinomas.
  • Traditionally, these tumors are treated with cytoreductive surgery followed by hyperthermic intraperitoneal chemotherapy.
  • A retrospective analysis was conducted to determine the benefit of modern systemic chemotherapy in patients with disseminated appendiceal neoplasm who were not considered optimal candidates for cytoreductive surgery.
  • Anderson Cancer Center tumor registry between January 2000 and July 2005.
  • RESULTS: Of 186 patients diagnosed with appendiceal neoplasm, 54 (29%) patients considered to be suboptimal surgical candidates received > or =2 cycles of systemic chemotherapy.
  • Thirty (55.6%) patients had a disease control rate noted as a complete response, partial response, or stable disease.
  • CONCLUSIONS: Systemic chemotherapy has a role in appendiceal neoplasm patients who are suboptimal candidates for cytoreductive surgery.
  • The intermediate PFS indicates the challenges that exist for appendiceal neoplasm patients in this setting.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Appendiceal Neoplasms / drug therapy
  • [MeSH-minor] Adult. Aged. Disease-Free Survival. Female. Humans. Hyperthermia, Induced. Injections, Intraperitoneal. Male. Middle Aged. Retrospective Studies. Survival Analysis

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  • (PMID = 19904805.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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38. Kim KJ, Moon W, Park MI, Park SJ, Lee SH, Chun BK: Gastrointestinal stromal tumor of appendix incidentally diagnosed by appendiceal hemorrhage. World J Gastroenterol; 2007 Jun 21;13(23):3265-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gastrointestinal stromal tumor of appendix incidentally diagnosed by appendiceal hemorrhage.
  • Gastrointestinal stromal tumor is rare, which arises from the mesenchymal tissues in the gastrointestinal tract, and it is extremely rare in the appendix.
  • Although the annual incidence of lower gastrointestinal bleeding has been increasing, bleeding related to the appendix is quite rare.
  • We herein present a very rare case of gastrointestinal stromal tumor incidentally found by appendiceal hemorrhage.
  • [MeSH-major] Appendiceal Neoplasms / diagnosis. Cecal Diseases / etiology. Gastrointestinal Hemorrhage / etiology. Gastrointestinal Stromal Tumors / diagnosis

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  • (PMID = 17589911.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4436618
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39. Hayama T, Matsuda K, Shibuya H, Akahane T, Horiuchi A, Shimada R, Aoyagi Y, Nakamura K, Yamada H, Ishihara S, Nozawa K, Watanabe T: A case of appendiceal Crohn's disease in which a laparoscopic appendectomy was performed. Int Surg; 2010 Oct-Dec;95(4):338-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of appendiceal Crohn's disease in which a laparoscopic appendectomy was performed.
  • She underwent a barium enema examination during a medical checkup, which revealed a wall irregularity around the appendix, but the appendix itself was not visualized.
  • The patient was referred to our hospital for possible appendiceal neoplasm.
  • Colonoscopy revealed a tumor-like protrusion with marked redness at the entrance to the appendix.
  • Differential diagnosis of appendiceal Crohn's disease or appendiceal neoplasm was made, and laparoscopic appendectomy was performed.
  • Pathologic examination revealed inflammation in all layers of the appendiceal wall and noncaseating epithelioid cell granuloma, and a diagnosis of appendiceal Crohn's disease was made.
  • [MeSH-major] Appendectomy / methods. Appendicitis / surgery. Crohn Disease / surgery. Laparoscopy
  • [MeSH-minor] Aged. Biopsy. Colonoscopy. Diagnosis, Differential. Female. Humans. Positron-Emission Tomography. Tomography, X-Ray Computed

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  • (PMID = 21309418.001).
  • [ISSN] 0020-8868
  • [Journal-full-title] International surgery
  • [ISO-abbreviation] Int Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Italy
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40. Benedix F, Reimer A, Gastinger I, Mroczkowski P, Lippert H, Kube R, Study Group Colon/Rectum Carcinoma Primary Tumor: Primary appendiceal carcinoma--epidemiology, surgery and survival: results of a German multi-center study. Eur J Surg Oncol; 2010 Aug;36(8):763-71

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary appendiceal carcinoma--epidemiology, surgery and survival: results of a German multi-center study.
  • BACKGROUND: While carcinoma of the colon is a common malignancy, primary carcinoma of the appendix is rare.
  • Many retrospective reviews outlined experience from different centers on appendiceal neoplasms.
  • The aim of this study was to analyze the type of surgery and survival of patients with appendiceal malignancies using data from a German multi-center observational study (31 341 patients).
  • METHODS: During a five-year period, 196 consecutive patients with malignant appendiceal tumors were distributed into four groups: appendiceal carcinoids, adenocarcinoma, mucinous adenocarcinoma and adenosquamous carcinoma.
  • Mean age at presentation was youngest for carcinoid tumors.
  • Carcinoid tumors had lowest tumor size and localized disease was present in 72.9%.
  • Overall 5-year survival was 83.1% for carcinoid vs. 49.2% for non-carcinoid tumors.
  • Histological subtype and tumor stage significantly affected survival.
  • CONCLUSIONS: Long-term outcome of carcinoid tumors is superior to non-carcinoid neoplasms.
  • Among all appendiceal neoplasms, adenosquamous carcinoma is the rarest histological subtype which is most commonly associated with advanced tumor stage and worst prognosis.
  • However, the high rate of right hemicolectomy in patients with small carcinoid tumors needs to be critically discussed.
  • [MeSH-major] Appendiceal Neoplasms / epidemiology. Appendiceal Neoplasms / surgery. Colectomy
  • [MeSH-minor] Adenocarcinoma / epidemiology. Adenocarcinoma / surgery. Adenocarcinoma, Mucinous / epidemiology. Adenocarcinoma, Mucinous / surgery. Adult. Aged. Appendicitis / diagnosis. Carcinoid Tumor / epidemiology. Carcinoid Tumor / surgery. Carcinoma, Adenosquamous / epidemiology. Carcinoma, Adenosquamous / surgery. Diagnosis, Differential. Female. Germany. Humans. Male. Middle Aged. Neoplasm Staging. Unnecessary Procedures / statistics & numerical data

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  • [Copyright] Copyright (c) 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20561765.001).
  • [ISSN] 1532-2157
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] England
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41. Greco L, Papa U: [Mucinous cystoadenocarcinoma of the appendix. A case report]. Ann Ital Chir; 2006 Jul-Aug;77(4):355-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Mucinous cystoadenocarcinoma of the appendix. A case report].
  • [Transliterated title] Il mucocele maligno dell'appendice vermiforme. Descrizione di un caso.
  • CASE REPORT: The Authors report a case of a 66-years-old male patient with mucinous cystoadenocarcinoma of the appendix.
  • Preoperative diagnosis was appendiceal mucocele.
  • At laparatomy was revealed the presence of a large mass of the appendix involving the caecum.
  • Hystology revealed diagnosis of mucinous cystoadenocarcinoma of the appendix.
  • After two weeks patient underwent right hemicolectomy, he is alive without disease at 36 months follow up.
  • Mucinous cystic neoplasms of the appendix is an uncommon disease that is rarely suspected before surgery.
  • The role of chemotherapy in the treatment of patients with appendiceal cancers remains controversial.
  • All patients with any form of appendiceal tumor appear to have an increased incidence of synchronous and metachronous neoplasms, especially in the gastrointestinal tract, and should be investigated and followed up appropriately.
  • [MeSH-major] Appendiceal Neoplasms. Cystadenocarcinoma, Mucinous

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  • (PMID = 17139968.001).
  • [ISSN] 0003-469X
  • [Journal-full-title] Annali italiani di chirurgia
  • [ISO-abbreviation] Ann Ital Chir
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
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42. Avcu S, Ozen O, Bulut MD, Bora A: Hepatic metastases of primary jejunal carcinoid tumor: A case report with radiological findings. N Am J Med Sci; 2009 Nov;1(6):305-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hepatic metastases of primary jejunal carcinoid tumor: A case report with radiological findings.
  • CONTEXT: Carcinoid tumors represent a group of well-differentiated tumors originating from the diffuse endocrine system outside the pancreas and thyroid.
  • The overall prevalence of carcinoid tumors in the United States is estimated to be one to two cases per 100,000 persons.
  • Various sites of origin of this neoplasm are appendix - 30-45%, small bowel - 25-35% (duodenum 2%, jejunum 7%, ileum 91%, multiple sites 15-35%), rectum 10-15%, caecum - 5%, and stomach - 0.5%.
  • CASE REPORT: Here we report a case of primary jejunal carcinoid tumor in a 66-year-old woman metastasizing to liver with ultrasonography, computed tomography, and diffusion-weighted magnetic resonance imaging (DWI) findings.
  • CONCLUSION: Primary jejunal carcinoid tumor is a rare entity.
  • DWI can help in the differential diagnosis of hepatic hypervascular metastatic mass lesions from benign ones, as well as in the diagnosis of carcinoid tumor.

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  • (PMID = 22666712.001).
  • [ISSN] 2250-1541
  • [Journal-full-title] North American journal of medical sciences
  • [ISO-abbreviation] N Am J Med Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3364631
  • [Keywords] NOTNLM ; Carcinoid / diffusion weighted MRI / jejunum / metastases / small bowel
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43. Avenel P, McKendrick A, Silapaswan S, Kolachalam R, Kestenberg W, Ferguson L, Jacobs MJ, Goriel Y, Mittal V: Gastrointestinal carcinoids: an increasing incidence of rectal distribution. Am Surg; 2010 Jul;76(7):759-63
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Carcinoid tumors are slow-growing and usually become symptomatic late in the course of the disease.
  • We evaluated our 10-year experience in the management of GI carcinoid tumors.
  • The rectum was the most common site for carcinoid tumors with an incidence of 30 per cent followed by jejunoileal at 29.3 per cent.
  • Other sites of carcinoid tumors were the appendix (8.3%), colon (8.3%), and duodenum (3.8%).
  • CT was not helpful in preoperative diagnosis of carcinoid tumor.
  • Fifteen patients died in follow-up with eight deaths related to carcinoid tumors, in the small bowel (6), rectum (1), and colon (1).
  • Overall survival was 68.7 per cent and mortality rate was 19.5 per cent from carcinoid tumors.
  • Most of the deaths occurred in patients with carcinoid syndrome, synchronous malignancy, and malignant carcinoid tumors.
  • The mean disease-free survival was 51 months (range, 15 to 138 months).
  • Screening colonoscopy, in addition to decreasing colorectal adenocarcinoma mortality, is useful in diagnosing carcinoid tumors at an earlier stage and in decreasing mortality from malignant colorectal carcinoid tumors.
  • [MeSH-major] Carcinoid Tumor / surgery. Gastrointestinal Neoplasms / surgery. Rectal Neoplasms / surgery

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  • (PMID = 20698387.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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44. Mavanur AA, Parimi V, O'Malley M, Nikiforova M, Bartlett DL, Davison JM: Establishment and characterization of a murine xenograft model of appendiceal mucinous adenocarcinoma. Int J Exp Pathol; 2010 Aug;91(4):357-67
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Establishment and characterization of a murine xenograft model of appendiceal mucinous adenocarcinoma.
  • We describe the clinical, pathologic and molecular characteristics of a xenograft model of metastatic mucinous appendiceal adenocarcinoma.
  • Tumours from patients with mucinous appendiceal neoplasms were implanted in nude mice and observed for evidence of intraperitoneal tumour growth.
  • Morphologic and immunohistochemical features, temporal growth characteristics relative to controls, and loss of heterozygosity (LOH) at multiple chromosomal alleles were assessed in a successfully engrafted tumour.
  • The successful xenograft is morphologically similar to the original tumour, produces abundant extracellular mucin and exhibits non-invasive growth on peritoneal surfaces.
  • The temporal growth characteristics of the xenograft tumour relative to controls reveal that tumour burden can be followed indirectly by measuring the weight or abdominal girth of engrafted animals.
  • The cytokeratin, mucin core protein, CDX2, Ki-67 and p53 expression patterns are identical in the xenograft and resected tumour and are consistent with the expected pattern of protein expression for mucinous adenocarcinoma of the appendix.
  • LOH was found in 1 of 10 informative chromosomal loci (chromosome 10p23) in xenograft tumour cells.
  • Although we were unable to engraft a low-grade appendiceal mucinous neoplasm, the engrafted adenocarcinoma will be useful for future evaluation of novel therapeutic strategies directed at mucinous appendiceal adenocarcinoma and evaluation of strategies for treating widespread, bulky, mucinous peritoneal surface neoplasms.
  • Xenograft tumour enrichment can facilitate molecular studies of appendiceal epithelial neoplasia.
  • [MeSH-major] Adenocarcinoma, Mucinous / secondary. Appendiceal Neoplasms / pathology. Peritoneal Neoplasms / secondary. Xenograft Model Antitumor Assays
  • [MeSH-minor] Animals. Cell Proliferation. Chromosomes, Human, Pair 10. Gene Expression Regulation, Neoplastic. Homeodomain Proteins / metabolism. Humans. Keratins / metabolism. Ki-67 Antigen / metabolism. Loss of Heterozygosity. Mice. Mice, Nude. Mucins / metabolism. Mutation. Proto-Oncogene Proteins / genetics. Time Factors. Tumor Burden. Tumor Suppressor Protein p53 / metabolism. ras Proteins / genetics

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  • [Cites] Cancer. 2001 Jul 1;92(1):85-91 [11443613.001]
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  • (PMID = 20586814.001).
  • [ISSN] 1365-2613
  • [Journal-full-title] International journal of experimental pathology
  • [ISO-abbreviation] Int J Exp Pathol
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / T32 CA113263
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CDX2 protein, human; 0 / Homeodomain Proteins; 0 / KRAS protein, human; 0 / Ki-67 Antigen; 0 / Mucins; 0 / Proto-Oncogene Proteins; 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53; 68238-35-7 / Keratins; EC 3.6.5.2 / ras Proteins
  • [Other-IDs] NLM/ PMC2962894
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45. Ko YH, Park SH, Jung CK, Won HS, Hong SH, Park JC, Roh SY, Woo IS, Kang JH, Hong YS, Byun JH: Clinical characteristics and prognostic factors for primary appendiceal carcinoma. Asia Pac J Clin Oncol; 2010 Mar;6(1):19-27

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical characteristics and prognostic factors for primary appendiceal carcinoma.
  • AIM: Primary adenocarcinoma of the appendix is a rare malignancy.
  • This study assessed prognostic factors affecting the clinical outcome in patients with appendiceal neoplasms.
  • The distribution of stages was: 26 (47.3%) with localized disease, five (9.1%) with regional disease, and 24 (43.6%) with distant metastatic disease.
  • Of the 34 patients who underwent curative resections of primary appendiceal carcinomas, the 3- and 5-year disease-free survival rates were 66.4% and 53.3%, respectively.
  • The recurrence rate was higher in patients with regional lymph node metastasis (HR vs node negative disease 23.4; P = 0.005) and high-grade tumors (HR vs low grade 6.3; P = 0.029).
  • CONCLUSION: High tumor grade and advanced stage were significantly predictive of poor survival outcome in patients with primary appendiceal carcinomas.
  • [MeSH-major] Adenocarcinoma / pathology. Appendiceal Neoplasms / pathology
  • [MeSH-minor] Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Prognosis. Retrospective Studies

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  • (PMID = 20398034.001).
  • [ISSN] 1743-7563
  • [Journal-full-title] Asia-Pacific journal of clinical oncology
  • [ISO-abbreviation] Asia Pac J Clin Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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46. Gatalica Z, Foster JM, Loggie BW: Low grade peritoneal mucinous carcinomatosis associated with human papilloma virus infection: case report. Croat Med J; 2008 Oct;49(5):669-73

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Pseudomyxoma peritonei is a clinical syndrome characterized by peritoneal dissemination of a mucinous tumor with mucinous ascites.
  • The vast majority of the pseudomyxoma peritonei are associated with mucinous neoplasms of the appendix.
  • No other primary mucinous tumor was identified and peritoneal carcinomatosis tested positive for high-risk human papilloma virus (HPV), showing both integrated and episomal pattern.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Papillomavirus Infections / complications. Peritoneal Neoplasms / diagnosis. Pseudomyxoma Peritonei / diagnosis. Pseudomyxoma Peritonei / etiology. Tumor Virus Infections / complications
  • [MeSH-minor] Adenocarcinoma / surgery. Female. Human papillomavirus 11. Human papillomavirus 16. Human papillomavirus 6. Humans. Middle Aged. Uterine Cervical Neoplasms / surgery

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  • [Cites] Cancer. 2001 Jul 1;92(1):85-91 [11443613.001]
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  • (PMID = 18925701.001).
  • [ISSN] 1332-8166
  • [Journal-full-title] Croatian medical journal
  • [ISO-abbreviation] Croat. Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
  • [Other-IDs] NLM/ PMC2582360
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47. Pretto G, Grando M, Chella N Jr, Bergold RA, de Castro RA, Santiago A: Anesthesia for peritonectomy with hyperthermic intraoperative peritoneal chemotherapy. Case report. Rev Bras Anestesiol; 2010 Sep-Oct;60(5):551-7
MedlinePlus Health Information. consumer health - Anesthesia.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND AND OBJECTIVES: Pseudomyxoma peritonei is a rare condition related to epithelial neoplasia of the appendix and ovaries.
  • [MeSH-major] Anesthesia. Hyperthermia, Induced. Intraoperative Care. Peritoneal Neoplasms / therapy. Peritoneum / surgery. Pseudomyxoma Peritonei / therapy

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  • [Copyright] Copyright © 2010 Elsevier Editora Ltda. All rights reserved.
  • (PMID = 20863936.001).
  • [ISSN] 1806-907X
  • [Journal-full-title] Revista brasileira de anestesiologia
  • [ISO-abbreviation] Rev Bras Anestesiol
  • [Language] eng; por
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Brazil
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48. Lohsiriwat V, Vongjirad A, Lohsiriwat D: Incidence of synchronous appendiceal neoplasm in patients with colorectal cancer and its clinical significance. World J Surg Oncol; 2009;7:51
MedlinePlus Health Information. consumer health - Colorectal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Incidence of synchronous appendiceal neoplasm in patients with colorectal cancer and its clinical significance.
  • BACKGROUND: The aims of this study were to evaluate the incidence of synchronous appendiceal neoplasm in patients with colorectal cancer, and to determine its clinical significance.
  • METHODS: Pathological reports and medical records were reviewed of patients with colorectal adenocarcinoma who underwent oncological resection of the tumor together with appendectomy at the Faculty of Medicine Siriraj Hospital, Mahidol University, Thailand between September 2000 and April 2008.
  • One patient (0.3 percent) had epithelial appendiceal neoplasm (mucinous cystadenoma) and 3 patients (1.0 percent) had metastatic colorectal cancer in the mesoappendix.
  • However, the presence of synchronous appendiceal tumors and/or metastasis did not alter postoperative management, as these patients had received adjuvant therapy and were scheduled for surveillance program because of nodal involvement.
  • CONCLUSION: The incidence of synchronous primary appendiceal neoplasm and secondary (metastatic) appendiceal neoplasm in colorectal cancer patients was 0.3 and 1.0 percent, respectively.
  • [MeSH-major] Appendiceal Neoplasms / epidemiology. Colorectal Neoplasms / epidemiology. Neoplasms, Multiple Primary / epidemiology

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  • (PMID = 19490638.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2698838
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49. Gupta S, Parsa V, Adsay V, Heilbrun LK, Smith D, Shields AF, Weaver D, Philip PA, El-Rayes BF: Clinicopathological analysis of primary epithelial appendiceal neoplasms. Med Oncol; 2010 Dec;27(4):1073-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinicopathological analysis of primary epithelial appendiceal neoplasms.
  • Appendiceal carcinomas are classified into three distinct histopathological disease entities: disseminated peritoneal adenomucinosis (DPAM), peritoneal mucinous carcinomatosis (PMCA), or peritoneal mucinous carcinomatosis with intermediate or discorant features (PMCA I/D).
  • The treatment of appendiceal tumors should be based on accurate histopathological classification, per previously reported case series.
  • The objective of this study was to evaluate the clinicopathologic presentation and outcome of patients with appendiceal tumors treated at our institution over a 15-year period.
  • We identified patients with appendiceal tumors diagnosed or treated at our institution from January 1989 through May 2004.
  • Chart review for age, gender, signs and symptoms at diagnosis, and treatment was performed.
  • Review of the pathologic specimens was performed and tumors were classified as DPAM, PMCA I/D, or PMCA.
  • Three distinct histopathological disease entities exist in appendiceal tumors.
  • The prognosis and management of these tumors should be based on the extent of disease and pathologic diagnosis.

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  • (PMID = 19851895.001).
  • [ISSN] 1559-131X
  • [Journal-full-title] Medical oncology (Northwood, London, England)
  • [ISO-abbreviation] Med. Oncol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P30 CA022453; United States / NCI NIH HHS / CA / CA-22453
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS513798; NLM/ PMC3883058
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50. Sugarbaker PH, Bijelic L: The porta hepatis as a site of recurrence of mucinous appendiceal neoplasms treated by cytoreductive surgery and perioperative intraperitoneal chemotherapy. Tumori; 2008 Sep-Oct;94(5):694-700
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The porta hepatis as a site of recurrence of mucinous appendiceal neoplasms treated by cytoreductive surgery and perioperative intraperitoneal chemotherapy.
  • BACKGROUND: A successful new treatment for a particular disease may change the natural history of that disease as patients go on to longer survival.
  • The goal of this study was to investigate the porta hepatis as a site of recurrence of appendiceal mucinous neoplasms.
  • METHODS: A prospective database on patients with peritoneal dissemination of mucinous appendiceal neoplasms has been maintained for 21 years.
  • In patients with complete cytoreduction, disease progression/recurrence in and around the porta hepatis has been noted as a new manifestation of this disease.
  • RESULTS: In 710 patients treated for mucinous appendiceal cancer with a complete cytoreduction, 140 developed recurrent disease.
  • Seven patients (5%) had disease recurrence in and around the porta hepatis.
  • CONCLUSIONS: Progression of mucinous neoplasms within the porta hepatis may be related to imperfect cytoreduction technique.
  • [MeSH-major] Adenocarcinoma, Mucinous / secondary. Adenocarcinoma, Mucinous / therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Appendectomy. Appendiceal Neoplasms / pathology. Appendiceal Neoplasms / therapy. Liver Neoplasms / secondary
  • [MeSH-minor] Adult. Appendicitis / surgery. Chemotherapy, Adjuvant. Disease Progression. Female. Humans. Infusions, Parenteral. Male. Middle Aged. Perioperative Care. Prospective Studies. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 19112943.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Italy
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51. Bruin SC, Verwaal VJ, Vincent A, van't Veer LJ, van Velthuysen ML: A clinicopathologic analysis of peritoneal metastases of colorectal and appendiceal origin. Ann Surg Oncol; 2010 Sep;17(9):2330-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A clinicopathologic analysis of peritoneal metastases of colorectal and appendiceal origin.
  • OBJECTIVE: To predict clinical outcome by classification of peritoneal metastases (PM) of colorectal or appendiceal origin.
  • BACKGROUND: This study investigates whether standardized histological classification can predict outcome for PM of colorectal or appendiceal origin treated with cytoreduction and hyperthermic intraperitoneal chemotherapy (HIPEC).
  • For overall survival (OS) and disease-free survival (DFS) Cox proportional-hazard models were constructed.
  • Covariates included tumor, patient, and treatment characteristics.
  • RESULTS: PM could be categorized into four groups: low-grade, well-differentiated mucinous tumor (DPAM); intermediated-grade mucinous carcinoma (PMCA-i); high-grade mucinous carcinoma (PMCA); and high-grade nonmucinous carcinoma (PCA).
  • Of PM originating from an appendix tumor, 29% were of non-DPAM type.
  • Of primary colorectal tumors, 37% resulted in mucinous PM, and another 26% of PM of colorectal origin had partly mucinous histology.
  • [MeSH-major] Adenocarcinoma, Mucinous / secondary. Appendiceal Neoplasms / pathology. Colorectal Neoplasms / pathology. Peritoneal Neoplasms / secondary
  • [MeSH-minor] Aged. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Neoplasm Staging. Prognosis. Survival Rate

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  • (PMID = 20232161.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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52. Tran TA, Holloway RW, Finkler NJ: Metastatic appendiceal mucinous adenocarcinoma to well-differentiated diffuse mesothelioma of the peritoneal cavity: a mimicker of florid mesothelial hyperplasia in association with neoplasms. Int J Gynecol Pathol; 2008 Oct;27(4):526-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic appendiceal mucinous adenocarcinoma to well-differentiated diffuse mesothelioma of the peritoneal cavity: a mimicker of florid mesothelial hyperplasia in association with neoplasms.
  • Atypical/florid mesothelial hyperplasia associated with another neoplastic process is not an infrequent phenomenon and has been reported in a variety of tumors.
  • The subsequent operation, however, demonstrated a mucinous neoplasm of the appendix with involvement of the peritoneal cavity in the form of peritoneal mucinous carcinomatosis as well as metastases to the uterine serosa and adnexal surfaces.
  • Microscopic analysis revealed an appendiceal adenocarcinoma with signet-ring-cell features that has metastasized to a diffuse well-differentiated mesothelioma of the peritoneal cavity.
  • To the best of our knowledge, this is the first report of a metastatic appendiceal mucinous adenocarcinoma to a well-differentiated diffuse mesothelioma of the peritoneal cavity.
  • This unusual case report expands the spectrum of mesothelial proliferation in conjunction with a malignant neoplasm and serves to remind pathologists that such a concomitant occurrence exists.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Appendiceal Neoplasms / pathology. Mesothelioma / pathology. Peritoneal Neoplasms / secondary
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Histocytochemistry. Humans

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  • (PMID = 18753969.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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53. Iwańczak B, Stawarski A, Czernik J, Bronowickip K, Iwańczak F, Pytrus T, Klempous J, Godziński J: [Diagnostic difficulties in pediatric abdominal pain with potential appendicitis]. Przegl Lek; 2007;64 Suppl 3:56-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Trudności diagnostyczne przyczyn bólów brzucha okolicy wyrostka robaczkowego u dzieci.
  • RESULTS: The most often Crohn's disease were recognized (9 children), in 2 cases with concomitant other pathologies (fecal tumor of appendix in one case and with peritoneal abscess after perforation of intestinal wall).
  • In one boy with ulcerative colitis, during exacerbation of the disease appendicitis complicated by rupture and peritonitis was observed.
  • Carcinoid of the appendix was the cause of abdominal pain in one child.
  • 3. All children with periappendipected of Crohn's disease.
  • 4. All children with equivocal presentations of appendicitis and with normal appendix during operation should undergo further diagnostic evaluation.
  • [MeSH-major] Abdominal Pain / etiology. Appendicitis / diagnosis
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Diagnosis, Differential. Female. Humans. Infant. Male

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  • (PMID = 18431916.001).
  • [ISSN] 0033-2240
  • [Journal-full-title] Przegla̧d lekarski
  • [ISO-abbreviation] Prz. Lek.
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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54. Hernández-Ramírez DA, Portela-Rubio G, Suárez-Moreno RM, Salazar-Lozano CR, Madrazo-Navarro M: [Mucocele of the appendix: an unusual finding in a patient with ulcerative colitis]. Cir Cir; 2010 Jul-Aug;78(4):357-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Mucocele of the appendix: an unusual finding in a patient with ulcerative colitis].
  • BACKGROUND: Patients with ulcerative colitis (UC) or Crohn's disease (CD) have an increased risk for the development of colorectal dysplasia and carcinoma.
  • Although appendiceal inflammation occurs histologically in 40-86% of colectomy specimens from patients with inflammatory bowel disease (IBD), appendiceal neoplasms have been reported only infrequently, and the notion of a direct association between IBD and appendiceal neoplasia is speculative.
  • Colonoscopy and biopsy established the diagnosis of UC (proctosigmoiditis).
  • Disease activity was moderate at the beginning and the patient initially received medical treatment with mesalazine and prednisone.
  • Final histological report revealed cystadenoma of the appendix.
  • CONCLUSIONS: We present the eighth patient, to our knowledge, with a primary cystadenoma of the appendix and UC.
  • [MeSH-major] Appendiceal Neoplasms / complications. Colitis, Ulcerative / complications. Cystadenoma / complications. Mucocele / etiology

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  • (PMID = 21167104.001).
  • [ISSN] 0009-7411
  • [Journal-full-title] Cirugía y cirujanos
  • [ISO-abbreviation] Cir Cir
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Mexico
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55. Caiazzo P, Comentale A, Rampone B, Di Lascio P, Morlino A, Pastore M, Del Vecchio G, Tramutoli PR: [Giant appendiceal mucocele during laparotomy for acute abdomen. Report of a case and brief review]. G Chir; 2010 Nov-Dec;31(11-12):511-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Giant appendiceal mucocele during laparotomy for acute abdomen. Report of a case and brief review].
  • The authors describe a case of giant appendiceal mucocele, secondary to a mucinous neoplasm of the appendix, diagnosed during laparotomy for acute abdomen.
  • By a review of the literature they stress the rarity of this lesion, the particular onset in their case as acute complication of appendiceal neoplasm with rupture of the intestinal wall, the difficulties of diagnosis and management in emergency.
  • [MeSH-major] Abdomen, Acute / surgery. Appendiceal Neoplasms / diagnosis. Appendix. Cystadenoma, Mucinous / diagnosis. Laparotomy. Mucocele / pathology. Mucocele / surgery
  • [MeSH-minor] Aged. Body Mass Index. Diagnosis, Differential. Female. Humans. Incidental Findings. Obesity / complications. Risk Factors. Treatment Outcome

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  • (PMID = 21232194.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Italy
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56. Abdalla MF, El-Hennawy HM: Unusual presentation for primary appendiceal lymphoma: A case report. Indian J Surg; 2010 Jul;72(Suppl 1):289-92

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Unusual presentation for primary appendiceal lymphoma: A case report.
  • Primary appendiceal neoplasms are uncommon, being found in approximately 0.5%-1.0% of appendectomy specimens at pathologic evaluation.
  • Primary appendiceal Burkitt's lymphomas are rare occurring in 0.015% of all gastrointestinal lymphomas.
  • Almost all reported cases of appendiceal lymphoma have proved to be non-Hodgkin lymphoma.
  • The majority of appendiceal lymphomas are of B-cell.
  • This report describes a rare case of primary appendiceal lymphoma in a patient presented with hematuria and dull aching right lower abdominal and back pain.

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  • [Cites] J Clin Oncol. 1994 Aug;12(8):1673-84 [8040680.001]
  • [Cites] Ann Oncol. 1993 Dec;4(10):831-7 [8117602.001]
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  • [Cites] AJR Am J Roentgenol. 2002 May;178(5):1123-7 [11959713.001]
  • (PMID = 23133274.001).
  • [ISSN] 0972-2068
  • [Journal-full-title] The Indian journal of surgery
  • [ISO-abbreviation] Indian J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3451848
  • [Keywords] NOTNLM ; Appendix / Burkitt’s / Lymphoma
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57. Deschamps L, Couvelard A: Endocrine tumors of the appendix: a pathologic review. Arch Pathol Lab Med; 2010 Jun;134(6):871-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Endocrine tumors of the appendix: a pathologic review.
  • CONTEXT: Although rare, appendiceal endocrine tumors are the most common neoplasms of the appendix.
  • OBJECTIVE: To provide recent data that focus on the pathology of endocrine tumors of the appendix including classifications and guidelines for patient management.
  • CONCLUSIONS: Appendiceal endocrine tumors are separated into 2 main groups: classic endocrine tumors and goblet cell carcinoids.
  • Evaluation of their prognoses and risks of malignancy, according to these classifications, depends on several parameters including tumor size, proliferation rate, and infiltration of appendiceal wall and mesoappendix.
  • Most patients with classic endocrine tumors of the appendix have a favorable prognosis.
  • Indications for postappendectomy, complementary surgery, which are still controversial, especially for tumors between 1 and 2 cm, are presented and discussed.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Carcinoma, Neuroendocrine / pathology
  • [MeSH-minor] Appendectomy. Carcinoid Tumor / classification. Carcinoid Tumor / diagnosis. Carcinoid Tumor / pathology. Colectomy. Humans. Prognosis. World Health Organization

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  • (PMID = 20524865.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 41
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58. Bijelic L, Yan TD, Sugarbaker PH: Treatment failure following complete cytoreductive surgery and perioperative intraperitoneal chemotherapy for peritoneal dissemination from colorectal or appendiceal mucinous neoplasms. J Surg Oncol; 2008 Sep 15;98(4):295-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Treatment failure following complete cytoreductive surgery and perioperative intraperitoneal chemotherapy for peritoneal dissemination from colorectal or appendiceal mucinous neoplasms.
  • BACKGROUND: Peritonectomy combined with perioperative intraperitoneal chemotherapy is a successful treatment option for patients with peritoneal dissemination of appendiceal and colorectal malignancy.
  • METHODS: Patients with peritoneal dissemination from appendiceal or colorectal malignancy who underwent complete cytoreduction and perioperative intraperitoneal chemotherapy were included in this study.
  • Data regarding recurrent disease found on abdominal exploration and/or diagnostic studies was extracted from a prospective database and analyzed.
  • RESULTS: Seventy patients with colorectal cancer carcinomatosis and 402 with appendiceal neoplasm were analyzed.
  • The median survival of 49 patients with colorectal cancer was 33 months while the median survival for patients with appendiceal neoplasms was not reached.
  • The most common type of recurrent disease was a localized intra-abdominal recurrence for both appendiceal and colon cancer patients.
  • Patients who underwent second surgery for recurrent disease had an improved survival.
  • This resulted in 5-year survival in 17% of colorectal patients and 70% of the appendiceal mucinous neoplasm patients.
  • [MeSH-major] Adenocarcinoma, Mucinous / therapy. Appendiceal Neoplasms / pathology. Chemotherapy, Cancer, Regional Perfusion / methods. Colorectal Neoplasms / pathology. Hyperthermia, Induced. Peritoneal Neoplasms / therapy

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  • (PMID = 18726900.001).
  • [ISSN] 1096-9098
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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59. Sugarbaker PH: The natural history, gross pathology, and histopathology of appendiceal epithelial neoplasms. Eur J Surg Oncol; 2006 Aug;32(6):644-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The natural history, gross pathology, and histopathology of appendiceal epithelial neoplasms.
  • AIM: To report the pathology of appendiceal epithelial neoplasms a review of the Washington Cancer Institute experience and a PubMed literature search was performed.
  • FINDINGS: Epithelial appendiceal neoplasms present a significant oncologic challenge.
  • CONCLUSIONS: Appendiceal epithelial neoplasms should be regarded as a distinct clinical entity with special clinical treatments used for optimal management.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Adenoma / pathology. Appendiceal Neoplasms / pathology

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  • (PMID = 16621426.001).
  • [ISSN] 0748-7983
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 17
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60. Mizuta Y, Akazawa Y, Shiozawa K, Ohara H, Ohba K, Ohnita K, Isomoto H, Takeshima F, Omagari K, Tanaka K, Yasutake T, Nakagoe T, Shirono K, Kohno S: Pseudomyxoma peritonei accompanied by intraductal papillary mucinous neoplasm of the pancreas. Pancreatology; 2005;5(4-5):470-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pseudomyxoma peritonei accompanied by intraductal papillary mucinous neoplasm of the pancreas.
  • This case is unique due to the concurrent presence of intraductal papillary mucinous neoplasm (IPMN) of the pancreas.
  • No primary tumour, including mucinous neoplasm of the appendix, was found.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Adenocarcinoma, Papillary / pathology. Carcinoma, Pancreatic Ductal / pathology. Pancreatic Neoplasms / pathology. Peritoneal Neoplasms / pathology. Pseudomyxoma Peritonei / pathology
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Ascites / pathology. Chemotherapy, Cancer, Regional Perfusion. Cisplatin / administration & dosage. Deoxycytidine / analogs & derivatives. Etoposide / administration & dosage. Humans. Hyperthermia, Induced. Infusions, Parenteral. Male. Middle Aged. Mitomycin / administration & dosage. Neoplasms, Multiple Primary

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  • [Copyright] Copyright 2005 S. Karger AG, Basel and IAP.
  • (PMID = 15983445.001).
  • [ISSN] 1424-3903
  • [Journal-full-title] Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
  • [ISO-abbreviation] Pancreatology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0W860991D6 / Deoxycytidine; 50SG953SK6 / Mitomycin; 6PLQ3CP4P3 / Etoposide; B76N6SBZ8R / gemcitabine; Q20Q21Q62J / Cisplatin
  • [Number-of-references] 19
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61. Wang HL, Dhall D: Goblet or signet ring cells: that is the question. Adv Anat Pathol; 2009 Jul;16(4):247-54
MedlinePlus Health Information. consumer health - Carcinoid Tumors.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Goblet cell carcinoid tumor is a rare mixed endocrine-exocrine neoplasm of the appendix.
  • It carries an intermediate biologic behavior between a classic carcinoid tumor and a conventional adenocarcinoma.
  • A recent retrospective study of a large number of appendiceal goblet cell carcinoids has shown that these tumors can be stratified into 3 subgroups based on careful histologic analysis: typical goblet cell carcinoid (group A); adenocarcinoma ex goblet cell carcinoid, signet ring cell type (group B); and adenocarcinoma ex goblet cell carcinoid, poorly differentiated carcinoma type (group C).
  • [MeSH-major] Adenocarcinoma / pathology. Appendiceal Neoplasms / pathology. Carcinoid Tumor / pathology. Carcinoma, Signet Ring Cell / pathology. Goblet Cells / pathology

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  • (PMID = 19546612.001).
  • [ISSN] 1533-4031
  • [Journal-full-title] Advances in anatomic pathology
  • [ISO-abbreviation] Adv Anat Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 11
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62. Palanivelu C, Rangarajan M, Annapoorni S, Senthilkumar R, Anand NV: Laparoscopic right hemicolectomy for goblet-cell carcinoid of the appendix: report of a rare case and literature survey. J Laparoendosc Adv Surg Tech A; 2008 Jun;18(3):417-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Laparoscopic right hemicolectomy for goblet-cell carcinoid of the appendix: report of a rare case and literature survey.
  • Tumors of the appendix are rare entities, and the majority of them are discovered accidentally during an investigation for other conditions.
  • Laparoscopic surgery for appendiceal goblet-cell carcinoid (GCC) has only been reported once before.
  • Our patient was incidentally discovered to have an appendiceal tumor and was referred to us for laparoscopy.
  • The tumor involved the body of the appendix and was adherent to the cecum.
  • Histopathology confirmed an appendiceal goblet-cell carcinoid.
  • GCC is a rare tumor of the appendix.
  • Hemicolectomy is indicated in specific situations, such as local involvement or tumor size >2 cm.
  • In our patient, the tumor was adherent to the cecum and tumor size was 5 cm.
  • Laparoscopic surgery for appendiceal tumors is safe, feasible, and even may be beneficial.
  • [MeSH-major] Carcinoid Tumor / surgery. Colectomy
  • [MeSH-minor] Aged. Appendiceal Neoplasms / pathology. Appendiceal Neoplasms / surgery. Humans. Laparoscopy. Male

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  • (PMID = 18503377.001).
  • [ISSN] 1092-6429
  • [Journal-full-title] Journal of laparoendoscopic & advanced surgical techniques. Part A
  • [ISO-abbreviation] J Laparoendosc Adv Surg Tech A
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 18
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63. Huang B, Di MJ, Liu HS, Qiu LL, Sun LJ, Xu JP: [Primary malignant tumor of the appendix: clinicopathological analysis of 22 cases]. Zhejiang Da Xue Xue Bao Yi Xue Ban; 2009 Mar;38(2):194-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Primary malignant tumor of the appendix: clinicopathological analysis of 22 cases].
  • OBJECTIVE: To investigate the clinicopathological and immunohistochemical features of primary malignant tumor of the appendix.
  • METHODS: The clinical data were reviewed; and histopathological and immunohistochemical features were analyzed in 22 cases with primary malignant tumor of the appendix.
  • RESULT: In 22 cases of primary malignant tumor of the appendix, 19 cases were carcinoid and 3 were adenocarcinoma.
  • CONCLUSION: Immunohistochemistry is useful in diagnosis of primary malignant tumor of the appendix, a rare type of cancer.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Carcinoid Tumor / pathology
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / pathology. Adenocarcinoma / surgery. Adolescent. Adult. Aged. Female. Humans. Immunohistochemistry. Male. Middle Aged. Young Adult

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  • (PMID = 19363829.001).
  • [ISSN] 1008-9292
  • [Journal-full-title] Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences
  • [ISO-abbreviation] Zhejiang Da Xue Xue Bao Yi Xue Ban
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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64. Murphy EM, Sexton R, Moran BJ: Early results of surgery in 123 patients with pseudomyxoma peritonei from a perforated appendiceal neoplasm. Dis Colon Rectum; 2007 Jan;50(1):37-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Early results of surgery in 123 patients with pseudomyxoma peritonei from a perforated appendiceal neoplasm.
  • PURPOSE: Epithelial appendiceal tumors are uncommon but can present as an emergency simulating appendicitis, or unexpectedly at laparotomy, laparoscopy, or on cross-sectional imaging.
  • We report the operative findings, pathologic assessment, and early outcomes in 123 consecutive patients with a perforated appendiceal neoplasm presenting as pseudomyxoma peritonei.
  • Complete tumor removal (cytoreduction) was attempted in selected patients and, if achieved, surgery was combined with intraoperative, intraperitoneal mitomycin C (10 mg/m(2)).
  • RESULTS: In total, 123 patients (52 males; 41 percent) underwent laparotomy for a perforated appendiceal malignancy presenting as pseudomyxoma peritonei.
  • Kaplan-Meier analysis of the 83 patients who had complete tumor removal predicted 75 percent disease-free survival at five years.
  • CONCLUSIONS: A perforated appendiceal epithelial tumor most frequently presents as pseudomyxoma peritonei.
  • This treatment strategy, involving surgery and intraperitoneal chemotherapy, can result in good outcomes in this rare and otherwise fatal disease.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Peritoneal Neoplasms / pathology. Pseudomyxoma Peritonei / pathology
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / analysis. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Postoperative Complications. Rupture

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  • [CommentIn] Nat Clin Pract Gastroenterol Hepatol. 2007 Sep;4(9):490-1 [17667901.001]
  • (PMID = 17115339.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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65. Cabanas J, Gomes da Silva R, Zappa L, Esquivel J, Cerruto C, Goldstein P, Sugarbaker PH: Splenic metastases from mucinous neoplasms of the appendix and colon. Tumori; 2006 Mar-Apr;92(2):104-12
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  • [Title] Splenic metastases from mucinous neoplasms of the appendix and colon.
  • AIMS AND BACKGROUND: Splenic metastases associated with mucinous intraabdominal tumors have been an enigma in the radiologic and oncology literature.
  • METHODS: Information on 9 patients who underwent splenectomy with intraparenchymal splenic masses associated with appendiceal or colorectal mucinous tumors with peritoneal dissemination was collected.
  • RESULTS: Eight of these patients had mucinous appendiceal tumors and 1 a mucinous sigmoid colon cancer.
  • These splenic tumor masses had a CT image compatible with metastases and not compatible with mucinous tumor layered out of the splenic capsule.
  • CONCLUSIONS: From our review of the clinical information available on these 9 patients, these splenic lesions were thought to be an entrapment of mucinous tumor within splenic surface trabeculae, which expand into the splenic parenchyma resembling metastatic disease.
  • [MeSH-major] Adenocarcinoma, Mucinous / secondary. Appendiceal Neoplasms / pathology. Colonic Neoplasms / pathology. Splenectomy. Splenic Neoplasms / secondary

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  • (PMID = 16724688.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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66. Omohwo C, Nieroda CA, Studeman KD, Thieme H, Kostuik P, Ross AS, Holter DR, Gushchin V, Merriman B, Sardi A: Complete cytoreduction offers longterm survival in patients with peritoneal carcinomatosis from appendiceal tumors of unfavorable histology. J Am Coll Surg; 2009 Sep;209(3):308-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Complete cytoreduction offers longterm survival in patients with peritoneal carcinomatosis from appendiceal tumors of unfavorable histology.
  • BACKGROUND: Cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) is a rapidly evolving treatment for metastatic appendiceal neoplasms.
  • The aim of this study was to show the effect of complete cytoreduction (CC) on survival in patients undergoing CRS and HIPEC for high-grade appendiceal neoplasm.
  • STUDY DESIGN: A retrospective study of a prospective database of 56 patients (from 1999 to 2007) with appendiceal neoplasms treated with CRS and HIPEC was carried out.
  • Histology of the disease, CC score, and peritoneal cancer index (PCI) score were assessed independently and collectively for each group of patients.
  • Survival analysis by tumor histology was 80% for patients with low-grade tumors and 52% for patients with high-grade tumors (p = 0.024).
  • There was no statistically significant difference in survival between the low-grade and high-grade tumors when a complete cytoreduction was performed in both groups of patients: 80% versus 68% (p = 0.69).
  • CONCLUSIONS: CRS and HIPEC is an effective treatment for patients with disseminated appendiceal tumors.
  • High-grade tumors also benefit from this approach and should not be excluded from CRS and HIPEC.
  • Every effort should be made to achieve a complete cytoreduction regardless of the tumor histology.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Appendiceal Neoplasms / pathology. Hyperthermia, Induced. Peritoneal Neoplasms / drug therapy. Peritoneal Neoplasms / secondary. Peritoneal Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Chi-Square Distribution. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Neoplasm Staging. Proportional Hazards Models. Reoperation. Retrospective Studies. Survival Analysis. Treatment Outcome

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  • (PMID = 19717034.001).
  • [ISSN] 1879-1190
  • [Journal-full-title] Journal of the American College of Surgeons
  • [ISO-abbreviation] J. Am. Coll. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Biomarkers, Tumor
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67. Aljarabah MM, Borley NR, Wheeler JM: Appendiceal adenocarcinoma presenting as left-sided large bowel obstruction, a case report and literature review. Int Semin Surg Oncol; 2007;4:20

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Appendiceal adenocarcinoma presenting as left-sided large bowel obstruction, a case report and literature review.
  • BACKGROUND: appendiceal tumours are rare, they may be encountered unexpectedly in any acute or elective abdominal operation, many of these tumours are not appreciated intraoperatively and are diagnosed only during formal histopathological analysis of an appendicectomy specimen.
  • Herein we present a case of appendiceal adenocarcinoma presenting as left-sided large bowel obstruction, we also review the literature of unusual presentations of appendiceal tumours.
  • CASE PRESENTATION: we report a case of left sided large bowel obstruction found to be secondary to an appendiceal adenocarcinoma.
  • The patient presented with abdominal pain, distension and constipation, CT scan showed large bowel obstruction thought to be due to a sigmoid tumour, on laparotomy the appendix was also noted to be abnormal.
  • A separate ileocaecal resection with end ileostomy was also performed, pathology specimens showed that the primary neoplasm was the appendix with metastasis to the distal sigmoid.
  • CONCLUSION: appendiceal tumours are rare, they usually present as acute appendicitis, other presentations are far less common.

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  • (PMID = 17662117.001).
  • [ISSN] 1477-7800
  • [Journal-full-title] International seminars in surgical oncology : ISSO
  • [ISO-abbreviation] Int Semin Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1948007
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68. Smeenk RM, Verwaal VJ, Antonini N, Zoetmulder FA: Survival analysis of pseudomyxoma peritonei patients treated by cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. Ann Surg; 2007 Jan;245(1):104-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • SUMMARY BACKGROUND DATA: PMP is a clinical syndrome characterized by progressive intraperitoneal accumulation of mucous and mucinous implants, usually derived from a ruptured mucinous neoplasm of the appendix.
  • The median disease-free interval was 25.6 months (95% confidence interval [CI], 14.8-43.6 months).
  • The 3-year and 5-year disease-free survival probability was 43.6% (95% CI, 34.4%-55.2%) and 37.4% (95% CI, 28.2%-49.5%), respectively.
  • The disease-specific 3-year and 5-year survival probability was 70.9% (95% CI, 62.0%-81.2%) and 59.5% (95% CI 48.7%-72.5%), respectively.
  • Factors associated with survival were pathological subtype, completeness of cytoreduction, and degree and location of tumor load (P < 0.05).
  • [MeSH-major] Antineoplastic Agents / administration & dosage. Hyperthermia, Induced. Peritoneal Neoplasms / drug therapy. Peritoneal Neoplasms / surgery. Pseudomyxoma Peritonei / drug therapy. Pseudomyxoma Peritonei / surgery

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  • (PMID = 17197972.001).
  • [ISSN] 0003-4932
  • [Journal-full-title] Annals of surgery
  • [ISO-abbreviation] Ann. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Other-IDs] NLM/ PMC1867935
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69. Soto Delgado M, Pedrero Márquez G, Varo Solís C, Rodríguez-Rubio Cortadellas FO, Sánchez Bernal C, González Moreno D: [Mucinous adenocarcinoma of the urachus and peritoneal pseudomyxoma]. Actas Urol Esp; 2006 Feb;30(2):222-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Adenocarcinoma mucinoso de uraco y pseudomixoma peritoneal.
  • The adenocarcinoma of the urachus is very rare tumor, with an incidence of 1/5.000.000 inhabitants, represents less than 0.001 of all types of bladder cancer.
  • Peritoneal pseudomixoma is a rare neoplasm characterized by mucinous acites that involvement the peritoneal surface and omentum.
  • Usually is associated with benign o malignant mucinous tumor of the appendix or ovary.

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  • (PMID = 16700214.001).
  • [ISSN] 0210-4806
  • [Journal-full-title] Actas urologicas españolas
  • [ISO-abbreviation] Actas Urol Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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70. Smeenk RM, van Velthuysen ML, Verwaal VJ, Zoetmulder FA: Appendiceal neoplasms and pseudomyxoma peritonei: a population based study. Eur J Surg Oncol; 2008 Feb;34(2):196-201
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Appendiceal neoplasms and pseudomyxoma peritonei: a population based study.
  • BACKGROUND: Pseudomyxoma peritonei (PMP) is a rare disease with an estimated incidence of 1 per million per year, and is thought to originate usually from an appendiceal mucinous epithelial neoplasm.
  • However it is not known exactly how often these neoplasms lead to PMP.
  • METHODS: The nationwide pathology database of the Netherlands (PALGA) was searched for the incidence of all appendectomies, the incidence of primary epithelial appendiceal lesions and the incidence and pathology history of patients with PMP.
  • An appendiceal lesion was found in 1482 appendiceal specimens (0.9%).
  • Coincidentally, an additional epithelial colonic neoplasm was found in 13% of patients with an appendiceal epithelial lesion.
  • A mucinous epithelial neoplasm was identified in 0.3% (73% benign, 27% malignant) of appendiceal specimens and 20% of these patients developed PMP.
  • For mucocele and non-mucinous neoplasm the association with PMP was only 2% and 3%, respectively.
  • The primary site was identified in 68% and dominated by the appendix (82%).
  • CONCLUSIONS: Primary epithelial lesions of the appendix are rare.
  • One third of these lesions are mucinous epithelial neoplasms and especially these tumours may progress into PMP.
  • Furthermore there is a considerable risk of an additional colonic epithelial neoplasm in patients with an epithelial neoplasm at appendectomy.
  • [MeSH-major] Adenocarcinoma, Mucinous / epidemiology. Appendiceal Neoplasms / epidemiology. Neoplasms, Multiple Primary / epidemiology. Peritoneal Neoplasms / epidemiology. Pseudomyxoma Peritonei / epidemiology

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  • (PMID = 17524597.001).
  • [ISSN] 1532-2157
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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71. Li C, Kanthan R, Kanthan SC: Pseudomyxoma peritonei--a revisit: report of 2 cases and literature review. World J Surg Oncol; 2006;4:60

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Pseudomyxoma peritonei (PMP) is a rare, chronic, relapsing, diagnostically challenging and poorly understood disease characterized by disseminated mucinous ascites and peritoneal implants.
  • CASE PRESENTATION: We report two cases of PMP that represent the two biological variants of disseminated peritoneal adenomucinosis (DPAM)--the benign variant and the peritoneal mucinous carcinomatosis (PMCA)--the malignant variant, both of which were characterized by multiple relapses and progression of the disease despite aggressive management.
  • CONCLUSION: Even with a better understanding and recent advances in the management of these cases, PMP remains an enigmatic disease with a protracted clinical course characterized by multiple recurrences despite surgery and/or chemotherapy.
  • Recognition of PMP as a delayed consequence years later should alert all surgeons to be extremely vigilant when treating mucinous neoplasms of the appendix, with special care being directed towards adequate excision and thorough debridement at the initial diagnosis.

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  • (PMID = 16945158.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1574320
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72. Bittle MM, Chew FS: Radiological reasoning: recurrent right lower quadrant inflammatory mass. AJR Am J Roentgenol; 2005 Sep;185(3 Suppl):S188-94
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • CT showed a right lower quadrant inflammatory mass presumed to be an appendiceal abscess.
  • The final pathologic diagnosis was mucinous cystadenoma with perforation.
  • CONCLUSION: Primary neoplasms of the appendix are uncommon but should be considered in the correct clinical and imaging scenario.
  • [MeSH-major] Abscess / radiography. Appendiceal Neoplasms / radiography. Appendicitis / radiography. Cystadenoma, Mucinous / radiography

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  • (PMID = 16120902.001).
  • [ISSN] 0361-803X
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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73. Liberale G, Lemaitre P, Noterman D, Moerman C, de Neubourg E, Sirtaine N, El Nakadi I: How should we treat mucinous appendiceal neoplasm? By laparoscopy or laparotomy? A case report. Acta Chir Belg; 2010 Mar-Apr;110(2):203-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] How should we treat mucinous appendiceal neoplasm? By laparoscopy or laparotomy? A case report.
  • Appendicular mucocele (AM) usually denotes a dilatation of the appendiceal lumen as a result of mucus accumulation that may be related to various neoplastic and non-neoplastic processes.
  • The macroscopic aspect of the appendix suggested the diagnosis intra-operatively and every effort was made to avoid cystic rupture during appendicular resection.
  • The histopathological diagnosis was mucinous cystadenoma.
  • [MeSH-major] Appendiceal Neoplasms / surgery. Appendix. Cecal Diseases / surgery. Cystadenoma, Mucinous / surgery. Laparoscopy. Laparotomy. Mucocele / surgery

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  • (PMID = 20514834.001).
  • [ISSN] 0001-5458
  • [Journal-full-title] Acta chirurgica Belgica
  • [ISO-abbreviation] Acta Chir. Belg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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74. Basic-Jukic N, Furic-Cunko V, Coric M, Bubic-Filipi LJ, Kastelan Z, Pasini J, Kes P: Appendiceal carcinoid and mucinous cystadenoma in renal transplant recipients: case reports. Transplant Proc; 2010 Jun;42(5):1704-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Appendiceal carcinoid and mucinous cystadenoma in renal transplant recipients: case reports.
  • There is an increased incidence of tumors among renal transplant patients, which are associated with immunosuppression.
  • Carcinoids are rare neuroendocrine tumors that arise from the enterochromaffin cells.
  • Although appendiceal carcinoid tumors are the commonest malignant neoplasms affecting the appendix, and mucinous cystadenoma is the commonest benign appendiceal neoplasm, they have not been reported in immunosuppressed patients.
  • We present two renal transplant recipients who developed combined appendiceal carcinoid and mucinous cystadenoma.
  • [MeSH-major] Appendiceal Neoplasms / etiology. Cystadenoma, Mucinous / etiology. Kidney Transplantation / adverse effects
  • [MeSH-minor] Adult. Female. Humans. Kidney Failure, Chronic / surgery. Magnetic Resonance Imaging. Male. Neoplasms / epidemiology. Neoplasms / etiology. Neoplasms / pathology. Neoplasms / surgery. Ovarian Neoplasms / pathology. Ovarian Neoplasms / surgery

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  • (PMID = 20620505.001).
  • [ISSN] 1873-2623
  • [Journal-full-title] Transplantation proceedings
  • [ISO-abbreviation] Transplant. Proc.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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75. Ross A, Sardi A, Nieroda C, Merriman B, Gushchin V: Clinical utility of elevated tumor markers in patients with disseminated appendiceal malignancies treated by cytoreductive surgery and HIPEC. Eur J Surg Oncol; 2010 Aug;36(8):772-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical utility of elevated tumor markers in patients with disseminated appendiceal malignancies treated by cytoreductive surgery and HIPEC.
  • BACKGROUND: Appendiceal malignancies with peritoneal spread have been successfully treated with Cytoreductive Surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC).
  • The aim of this study is to clarify the utility of common tumor markers in selecting patients for the combined treatment.
  • METHODS: Data on 56 patients with appendiceal neoplasms treated with CRS and HIPEC were prospectively collected.
  • Chi square test was used to analyze a link between common tumor markers and completeness of cytoreduction score (CC score) and preoperative peritoneal cancer index score (PCI score).
  • Hazard ratio of disease related death was 5.6 (95% CI, 1.8-17.2) among patients with high CC score as compared to those with low CC score.
  • Number of abnormal tumor markers (0 vs 1/2/3) correlated with PCI score 16.2 vs 32.5 (p < 0.001) but not with completeness of cytoreduction or survival.
  • CONCLUSIONS: Multiple abnormal tumor markers were not useful as an exclusion criterion for patients undergoing CRS.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Appendiceal Neoplasms / immunology. Appendiceal Neoplasms / surgery. Biomarkers, Tumor / blood. Chemotherapy, Cancer, Regional Perfusion. Hyperthermia, Induced. Peritoneal Neoplasms / immunology. Peritoneal Neoplasms / surgery

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  • [Copyright] Copyright (c) 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20561764.001).
  • [ISSN] 1532-2157
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CA-125 Antigen; 0 / CA-19-9 Antigen; 0 / Carcinoembryonic Antigen
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76. Osborne CL, Boulind CE, Cooper E, Francis NK: Incidental cystadenocarcinoma of the appendix in a patient undergoing laparoscopic right hemicolectomy for caecal cancer: a case report. Cases J; 2009;2:7505

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Incidental cystadenocarcinoma of the appendix in a patient undergoing laparoscopic right hemicolectomy for caecal cancer: a case report.
  • Primary appendiceal neoplasms are rare and usually found incidentally after appendicectomy for suspected appendicitis.
  • We report a case of a perforated cystadenocarcinoma of the appendix occurring synchronously with caecal adenocarcinoma in an 81-year-old woman without abdominal symptoms or signs, who presented with iron deficiency anaemia.

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  • (PMID = 19829982.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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77. Young RH: From krukenberg to today: the ever present problems posed by metastatic tumors in the ovary: part I. Historical perspective, general principles, mucinous tumors including the krukenberg tumor. Adv Anat Pathol; 2006 Sep;13(5):205-27
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] From krukenberg to today: the ever present problems posed by metastatic tumors in the ovary: part I. Historical perspective, general principles, mucinous tumors including the krukenberg tumor.
  • This review considers historical aspects of metastatic tumors to the ovary, general principles that aid in their evaluation, and metastatic mucinous tumors, including the Krukenberg tumor.
  • The historical timeline on the Krukenberg tumor dates back to the legendary Sir James Paget and the story is followed through the well-known, albeit flawed, contribution of Friedrich Krukenberg and others who have contributed important papers over the years, including the overlooked contribution of the French investigator Gauthier-Villars.
  • Contributions on mucinous tumors conclude the historical perspective, note being made of the recent evidence suggesting that the long held contention of Dr Robert E.
  • Scully that ovarian mucinous tumors in patients with pseudomyxoma peritonei usually originate from the appendix is correct.
  • The section on general principles highlights the many clinical, gross, microscopic, and special techniques such as immunohistochemistry that may aid in determining that an ovarian tumor is metastatic with emphasis on the first 3 mentioned aspects.
  • Problematic features such as a tendency for metastatic tumors to be cystic, even when the primary tumors are not, and for many metastatic tumors to mature in the ovary (so-called maturation phenomenon), are emphasized.
  • The contribution on the Krukenberg tumor reviews the varied microscopy of this tumor pointing out that the well-known pattern of signet-ring cells in a cellular stroma, albeit characteristic, is often not striking and frequently overshadowed by other microscopic features.
  • The final portion of the essay reviews mucinous tumors of non-Krukenberg type, beginning with those that originate from the appendix.
  • The appendiceal neoplasms have distinctive features in most cases being particularly well differentiated, and this is also seen in their ovarian metastases.
  • Other mucinous tumors that commonly simulate closely metastatic neoplasms, include those from the pancreas in particular, but also diverse other sites, are then reviewed.
  • [MeSH-major] Krukenberg Tumor / secondary. Medical Oncology / history. Ovarian Neoplasms / secondary
  • [MeSH-minor] Adenocarcinoma, Mucinous / secondary. Appendiceal Neoplasms / pathology. Diagnosis, Differential. Female. History, 20th Century. Humans. Pancreatic Neoplasms / pathology. Periodicals as Topic / history

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  • (PMID = 16998315.001).
  • [ISSN] 1072-4109
  • [Journal-full-title] Advances in anatomic pathology
  • [ISO-abbreviation] Adv Anat Pathol
  • [Language] eng
  • [Publication-type] Historical Article; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 70
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78. Byrn JC, Wang JL, Divino CM, Nguyen SQ, Warner RR: Management of goblet cell carcinoid. J Surg Oncol; 2006 Oct 1;94(5):396-402
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND AND OBJECTIVES: Goblet cell carcinoid, a rare tumor of intermediate malignant potential, is known to account for a significant minority of appendiceal neoplasms.
  • Presenting diagnoses included appendicitis (n=8), abdominal or liver mass (n=5), uterine fibroids (n=1), ovarian mass (n=1), and Crohn's Disease exacerbation (n=1).
  • Patients were divided into two groups: those where the diagnosis was an incidental finding at operation (Group 1) and those where the presentation was of an abdominal mass or metastatic disease (Group 2).
  • CONCLUSIONS: Goblet cell carcinoid is a rare malignant tumor largely affecting the appendix.
  • In patients presenting with appendicitis, our series does not support the recommendation of right hemicolectomy based on pathologic diagnosis alone and surgical intervention must be customized to the individual patient.
  • [MeSH-major] Appendiceal Neoplasms / therapy. Carcinoid Tumor / therapy. Gastrointestinal Neoplasms / therapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Appendectomy. Appendicitis / complications. Appendicitis / surgery. Colectomy. Female. Humans. Incidental Findings. Liver Neoplasms / diagnosis. Male. Middle Aged. Ovarian Neoplasms / diagnosis. Retrospective Studies. Uterine Neoplasms / diagnosis

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  • [Copyright] Copyright (c) 2006 Wiley-Liss, Inc.
  • (PMID = 16967437.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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79. Puebla-Maestu A, Martín-Lorente JL, Gento-Peña E, Alonso-Alonso E, Claver-Criado M, Fernández-Fernández A: [Microhematuria secondary to mucocele and appendicular cystoadenoma]. Gastroenterol Hepatol; 2006 Jan;29(1):25-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Appendiceal mucocele is a rare entity consisting of cystic dilatation of the appendix as a result of increased mucus production.
  • This appendiceal neoplasm is frequently associated with other extraintestinal and colonic tumors and therefore adequate abdominal examination is necessary.
  • We describe the case of a woman with hematuria associated with an appendiceal mucocele.
  • Survival in patients with appendiceal cystadenoma is excellent.
  • [MeSH-major] Appendiceal Neoplasms / diagnosis. Cystadenoma / diagnosis. Mucocele / diagnosis

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  • (PMID = 16393627.001).
  • [ISSN] 0210-5705
  • [Journal-full-title] Gastroenterología y hepatología
  • [ISO-abbreviation] Gastroenterol Hepatol
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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80. Yonemura Y, Tsukiyama G, Miyata R, Sako S, Endou Y, Hirano M, Mizumoto A, Matsuda T, Takao N, Ichinose M, Miura M, Hagiwara A, Li Y: Indication of peritonectomy for peritoneal dissemination. Gan To Kagaku Ryoho; 2010 Nov;37(12):2306-11
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  • Each of the 95, 58, 316, 31, 10 and 11 patients were from gastric, colorectal, appendiceal, ovarian, small bowel cancer and mesothelioma, respectively.
  • Peritonectomy was performed with a radical resection of the primary tumor and all gross PC with involved organs, peritoneum, or tissue that was deemed technically feasible and safe for the patient.
  • In appendiceal neoplasm, patients with PCI score less than 28 showed significantly better survival than those with PCI score greater than 29.
  • Among the various prognostic factors in appendiceal neoplasm and gastric cancer patients, CC-0 complete cytoreduction was the most important independent prognostic factor.
  • Peritonectomy is done to remove macroscopic disease and perioperative intraperitoneal chemotherapy to eradicate microscopic residual disease aiming to remove disease completely with a single procedure.
  • [MeSH-major] Carcinoma / surgery. Peritoneal Neoplasms / surgery. Peritoneum / surgery
  • [MeSH-minor] Aged. Appendiceal Neoplasms / drug therapy. Appendiceal Neoplasms / surgery. Colorectal Neoplasms / drug therapy. Colorectal Neoplasms / surgery. Combined Modality Therapy. Female. Humans. Intestinal Neoplasms / drug therapy. Intestinal Neoplasms / surgery. Male. Mesothelioma / drug therapy. Mesothelioma / surgery. Ovarian Neoplasms / drug therapy. Ovarian Neoplasms / surgery. Postoperative Complications. Stomach Neoplasms / drug therapy. Stomach Neoplasms / surgery. Treatment Outcome

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  • (PMID = 21224556.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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81. Toyomasu Y, Tsutsumi S, Yamaguchi S, Mochiki E, Asao T, Kuwano H: Laparoscopy-assisted ileocecal resection for mucosa-associated lymphoid tissue lymphoma of the appendix: case report. Hepatogastroenterology; 2009 Jul-Aug;56(93):1078-81
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  • [Title] Laparoscopy-assisted ileocecal resection for mucosa-associated lymphoid tissue lymphoma of the appendix: case report.
  • A 74-year-old female had repeated relapses of right lower abdominal pain; a colonoscopic examination showed a submucosal tumor of the appendix.
  • Under provisional diagnosis of appendicitis caused by a submucosal tumor, a laparoscopic operation was performed.
  • The laparoscopic observation did not reveal the typical finding of appendicitis.
  • The tumor was thought to be a malignant neoplasm.
  • The ileocecal region was excised with lymph node dissection.
  • Macroscopically, the mass was localized in the appendix and did not infiltrate to the cecum.
  • Immunohistochemically, the tumor cells were positive for CD20 and CD79a and negative for CD3, CD10, and cyclin D1.
  • The histological diagnosis was mucosa-associated lymphoid tissue (MALT) lymphoma of the appendix.
  • Furthermore, very few cases of the appendiceal MALT lymphoma have been reported.
  • The laparoscopy was used in the case of a patient diagnosed with appendicitis and considered the possibility of MALT lymphoma of the appendix.
  • We then performed an ileocecal resection, which is considered radical surgery.
  • The present case suggests that a laparoscopic observation is helpful for the appropriate diagnosis and therapy of MALT lymphoma of the appendix.
  • [MeSH-major] Appendiceal Neoplasms / surgery. Laparoscopy. Lymphoma, B-Cell, Marginal Zone / surgery
  • [MeSH-minor] Aged. Cecum / pathology. Cecum / surgery. Colonography, Computed Tomographic. Colonoscopy. Diagnosis, Differential. Female. Humans. Ileum / pathology. Ileum / surgery. Lymph Node Excision

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  • (PMID = 19760945.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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82. Tang LH, Shia J, Soslow RA, Dhall D, Wong WD, O'Reilly E, Qin J, Paty P, Weiser MR, Guillem J, Temple L, Sobin LH, Klimstra DS: Pathologic classification and clinical behavior of the spectrum of goblet cell carcinoid tumors of the appendix. Am J Surg Pathol; 2008 Oct;32(10):1429-43
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  • [Title] Pathologic classification and clinical behavior of the spectrum of goblet cell carcinoid tumors of the appendix.
  • Appendiceal tumors exhibiting both neuroendocrine and glandular differentiation are uncommon and have caused difficulty in pathologic classification, prediction of prognosis, and clinical management.
  • In this study, we undertook a retrospective investigation of 63 such cases and classified them as typical GCC (group A) and adenocarcinoma ex GCC on the basis of the histologic features of the tumor at the primary site.
  • The clinical characteristics and prognosis were compared within these groups and with conventional de novo appendiceal adenocarcinomas.
  • Both groups A and B tumors shared a similar immunoprofile, which included generally focal immunoreactivity for neuroendocrine markers, and a normal intestinal type mucin glycoprotein profile (negative MUC1 expression and preserved MUC2 immunoreactivity).
  • The proliferative index was relatively low in these tumors and slightly increased from groups A to B tumors (11% to 16%).
  • Both beta-catenin and E-cadherin exhibited a normal membranous staining pattern in groups A and B tumors.
  • The overall disease-specific survival for all subtypes was 77%, with 46% of patients without evidence of disease and 31% alive with disease.
  • All the patients with clinical stage of I or IIA disease had a favorable outcome after appropriate surgery with or without chemotherapy.
  • Although most patients (63%) with GCC presented at an advanced clinical stage, their clinical outcome could be differentiated by subclassification of tumors.
  • In conclusion, GCC is a distinctive appendiceal neoplasm that exhibits unique pathologic features and clinical behavior.
  • [MeSH-major] Adenocarcinoma / pathology. Appendiceal Neoplasms / pathology. Carcinoid Tumor / pathology. Carcinoma, Signet Ring Cell / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antineoplastic Agents / therapeutic use. Appendectomy. Cell Differentiation. Cell Proliferation. Chemotherapy, Adjuvant. Colectomy. Disease-Free Survival. Female. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Neoplasm Staging. Observer Variation. Retrospective Studies. Terminology as Topic. Time Factors. Treatment Outcome

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  • [CommentIn] Am J Surg Pathol. 2009 Aug;33(8):1259-60; author reply 1260-1 [19471156.001]
  • (PMID = 18685490.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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83. Sugarbaker PH: New standard of care for appendiceal epithelial neoplasms and pseudomyxoma peritonei syndrome? Lancet Oncol; 2006 Jan;7(1):69-76
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] New standard of care for appendiceal epithelial neoplasms and pseudomyxoma peritonei syndrome?
  • Appendiceal mucinous neoplasms sometimes present with peritoneal dissemination, which was previously a lethal condition with a median survival of about 3 years.
  • Now, visible disease tends to be removed through visceral resections and peritonectomy.
  • To avoid entrapment of tumour cells at operative sites and to destroy small residual mucinous tumour nodules, cytoreductive surgery is combined with intraperitoneal chemotherapy with mitomycin at 42 degrees C.
  • If the mucinous neoplasm is minimally invasive and cytoreduction complete, these treatments result in a 20-year survival of 70%.
  • In the absence of a phase III study, this new combined treatment should be regarded as the standard of care for epithelial appendiceal neoplasms and pseudomyxoma peritonei syndrome.
  • [MeSH-major] Appendiceal Neoplasms / drug therapy. Appendiceal Neoplasms / surgery. Peritoneal Neoplasms / drug therapy. Pseudomyxoma Peritonei / drug therapy. Pseudomyxoma Peritonei / surgery

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  • (PMID = 16389186.001).
  • [ISSN] 1470-2045
  • [Journal-full-title] The Lancet. Oncology
  • [ISO-abbreviation] Lancet Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 50SG953SK6 / Mitomycin; U3P01618RT / Fluorouracil
  • [Number-of-references] 38
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84. Nishio R, Furuya Y, Akashi T, Okumura A, Fuse H: Primary adenocarcinoma of the appendix invading the urinary bladder. Int Urol Nephrol; 2006;38(3-4):481-2
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  • [Title] Primary adenocarcinoma of the appendix invading the urinary bladder.
  • We report a case of adenocarcinoma of the appendix invading the urinary bladder in a 75-year-old man.
  • Although cystoscopic examination and computed tomography suggested a primary or secondary bladder tumor, repeated transurethral bladder biopsy could not confirm the neoplasm.
  • At operation a primary neoplasm of the appendix invading the bladder was discovered and en bloc resection of the urinary bladder with the adherent cecum followed by an ileocolonic anastomosis and ureterocutaneostomy was performed.
  • [MeSH-major] Adenocarcinoma / pathology. Appendiceal Neoplasms / pathology. Urinary Bladder Neoplasms / pathology
  • [MeSH-minor] Aged. Fatal Outcome. Humans. Male. Neoplasm Invasiveness

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  • (PMID = 17160444.001).
  • [ISSN] 0301-1623
  • [Journal-full-title] International urology and nephrology
  • [ISO-abbreviation] Int Urol Nephrol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Hungary
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85. Pahlavan PS, Kanthan R: Goblet cell carcinoid of the appendix. World J Surg Oncol; 2005 Jun 20;3:36

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Goblet cell carcinoid of the appendix.
  • BACKGROUND: Goblet cell carcinoid (GCC) of the appendix is a rare neoplasm that share histological features of both adenocarcinoma and carcinoid tumor.
  • The clinical presentations of this neoplasm are also varied.
  • This review summarizes the published literature on GCC of the appendix.
  • The focus is on its diagnosis, histopathological aspects, clinical manifestations, and management.
  • METHODS: Published studies in the English language between 1966 to 2004 were identified through Medline keyword search utilizing terms "goblet cell carcinoid," "adenocarcinoid", "mucinous carcinoid" and "crypt cell carcinoma" of the appendix.
  • RESULTS: Based on the review of 57 published papers encompassing nearly 600 diagnosed patients, the mean age of presentation for GCC of the appendix was 58.89 years with equal representation in both males and females.
  • Accurate diagnosis of this neoplasm requires astute observations within an acutely inflamed appendix as this neoplasm has a prominent pattern of submucosal growth and usually lacks the formation of a well-defined tumor mass.
  • Concomitant distant metastasis at diagnosis was present in 11.16% of patients with the ovaries being the most common site in 3.60% followed by disseminated abdominal carcinomatosis in 1.03%.
  • Local lymph node involvement was seen in 8.76% of patients at the time of diagnosis.
  • GCC's of the appendix remains a neoplasm of unpredictable biological behavior and thus warrants lifelong surveillance for recurrence of the disease upon diagnosis and successful surgical extirpation.
  • CONCLUSION: GCC of the appendix is a rare neoplasm.
  • Due to its wide range of presentation, this tumor should be considered as a possible diagnosis in many varied situations leading to abdominal surgery.
  • The advocated plan of management recommended for patients with tumors that involve the adjacent caecum or with high-grade tumors with histological features such as an increased mitotic rate involve initial appendectomy with completion right hemicolectomy due to the high possibility of local recurrence with intraperitoneal seeding prior to lymph node involvement and a 20% risk of metastatic behavior.
  • In female patients with GCC of the appendix regardless of age, bilateral salpingo-oophorectomy is advocated.
  • In cases with obvious spread of the disease chemotherapy, mostly with 5-FU and leucovorin is advised.

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  • (PMID = 15967038.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1182398
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86. Stewart JH 4th, Shen P, Russell GB, Bradley RF, Hundley JC, Loggie BL, Geisinger KR, Levine EA: Appendiceal neoplasms with peritoneal dissemination: outcomes after cytoreductive surgery and intraperitoneal hyperthermic chemotherapy. Ann Surg Oncol; 2006 May;13(5):624-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Appendiceal neoplasms with peritoneal dissemination: outcomes after cytoreductive surgery and intraperitoneal hyperthermic chemotherapy.
  • BACKGROUND: Appendiceal neoplasms frequently present with peritoneal dissemination (PD) and have a clinical course marked by bowel obstruction and subsequent death.
  • Few data have correlated outcome with appendiceal histology after cytoreductive surgery and intraperitoneal hyperthermic chemotherapy (IPHC).
  • We have reviewed our experience with cytoreductive surgery and IPHC for PD from the appendix.
  • METHODS: A total of 110 cases of PD from proven appendiceal neoplasms treated with IPHC were identified from a prospectively managed database.
  • Tumor samples were classified on pathologic review as disseminated peritoneal adenomucinosis (n = 55), peritoneal mucinous carcinomatosis (PMCA) with intermediate features (n = 18), PMCA (n = 29), or high-grade nonmucinous lesions (n = 8).
  • RESULTS: A total of 116 IPHCs were performed on 110 patients for appendiceal PD between 1993 and 2004.
  • When stratified by histology, disseminated peritoneal adenomucinosis and intermediate tumors had better 3-year survival rates (77% +/- 7% and 81% +/- 10%) than PMCA and high-grade nonmucinous lesions (35% +/- 10% and 15% +/- 14%; P = .0032 for test of differences between groups).
  • Age at presentation (P = .0134), performance status (P < .0001), time between diagnosis and IPHC (P = .0011), resection status (P = .0044), and length of hyperthermic chemoperfusion (P = .0193) were independently associated with survival.
  • CONCLUSIONS: The data show that long-term survival is anticipated in most patients who are treated with cytoreduction and IPHC for appendiceal PD.
  • In all, this work establishes a framework for the consideration of IPHC in future trials for appendiceal PD.
  • [MeSH-major] Adenocarcinoma, Mucinous / drug therapy. Adenocarcinoma, Mucinous / surgery. Appendiceal Neoplasms / pathology. Peritoneal Neoplasms / drug therapy. Peritoneal Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Chi-Square Distribution. Combined Modality Therapy. Disease Progression. Female. Humans. Hyperthermia, Induced. Male. Middle Aged. Prognosis. Retrospective Studies. Survival Rate. Treatment Outcome

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  • [CommentIn] Ann Surg Oncol. 2006 May;13(5):597-9 [16538404.001]
  • (PMID = 16538401.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / K08 CA131482
  • [Publication-type] Journal Article
  • [Publication-country] United States
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87. Lepistö A, Osterlund P, Järvinen HJ: [Treatment of pseudomyxoma peritonei is developing]. Duodecim; 2010;126(14):1693-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In pseudomyxoma peritonei a mucinous tumor of the appendix spreads into the abdominal cavity.
  • Cytologic picture of the tumor may be benign, malignant or intermediary.
  • The symptoms were previously relieved by repeated resections of the tumor mass, whereby even the most benign form of the disease progressed slowly.
  • [MeSH-major] Peritoneal Neoplasms / drug therapy. Peritoneal Neoplasms / surgery. Pseudomyxoma Peritonei / drug therapy. Pseudomyxoma Peritonei / surgery
  • [MeSH-minor] Antineoplastic Agents / administration & dosage. Appendix / pathology. Combined Modality Therapy. Disease Progression. Humans. Neoplasm Invasiveness. Therapeutic Irrigation / methods

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  • (PMID = 20804088.001).
  • [ISSN] 0012-7183
  • [Journal-full-title] Duodecim; lääketieteellinen aikakauskirja
  • [ISO-abbreviation] Duodecim
  • [Language] fin
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Finland
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 22
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88. Elias D, Glehen O, Pocard M, Quenet F, Goéré D, Arvieux C, Rat P, Gilly F, Association Française de Chirurgie: A comparative study of complete cytoreductive surgery plus intraperitoneal chemotherapy to treat peritoneal dissemination from colon, rectum, small bowel, and nonpseudomyxoma appendix. Ann Surg; 2010 May;251(5):896-901

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A comparative study of complete cytoreductive surgery plus intraperitoneal chemotherapy to treat peritoneal dissemination from colon, rectum, small bowel, and nonpseudomyxoma appendix.
  • OBJECTIVE: To report a large number of patients with peritoneal carcinomatosis (PC) treated with complete cytoreductive (CCR-0) plus intraperitoneal chemotherapy, and to compare the results according to the origin of the primary: colon, rectum, small bowel, and appendix (excluding peritoneal pseudomyxoma).
  • Primary sites were: colon (n=341), rectum (n=27), appendix (n=41), and small bowel (n=31).
  • RESULTS: Postoperative mortality and morbidity (3.9% and 31%, respectively) did not differ according to the origin of the primary tumor.
  • The 5-year overall survival rates were not statistically different for the colon (29.7%), rectum (37.9%), nor the small bowel (33.8%), but was higher (P=0.01) for appendix adenocarcinoma (63.2%).
  • The multivariate analysis of prognostic factors singled out the extent of peritoneal seeding (P<0.0001), positive lymph nodes (P=0.001), and adjuvant systemic chemotherapy (P=0.002), whereas the origin of the tumor was borderline (P=0.06) in favor of appendix tumors.
  • Results were better for appendix adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / secondary. Appendiceal Neoplasms / pathology. Colonic Neoplasms / pathology. Intestinal Neoplasms / pathology. Peritoneal Neoplasms / secondary. Peritoneal Neoplasms / surgery. Rectal Neoplasms / pathology
  • [MeSH-minor] Combined Modality Therapy. Humans. Infusions, Parenteral. Liver Neoplasms / secondary. Multivariate Analysis. Prognosis

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  • (PMID = 20395843.001).
  • [ISSN] 1528-1140
  • [Journal-full-title] Annals of surgery
  • [ISO-abbreviation] Ann. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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89. Abdu B, Hobgood D, Stallings S, Depasquale S: Incidental finding of pseudomyxoma peritonei at primary cesarean section. Am J Perinatol; 2009 Oct;26(9):633-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Incidental finding of pseudomyxoma peritonei at primary cesarean section.
  • Primary appendiceal carcinoma is extremely rare and is found in approximately 1% of appendectomy specimens.
  • Neoplasms of the appendix that secrete mucin such as adenocarcinoma may rupture, leading to intraperitoneal seeding of the peritoneum and producing the clinical picture of pseudomyxoma peritonei (PMP).
  • A general surgeon was consulted, and grossly necrotic-appearing appendix was noted.
  • Pathology showed well-differentiated mucinous adenocarcinoma of the appendix.
  • Early diagnosis of a potentially life-threatening disease requires that clinicians expand the differential diagnosis and consider the possibility of a malignant neoplasm presenting in the pregnant female.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Cesarean Section. Incidental Findings. Pseudomyxoma Peritonei / pathology
  • [MeSH-minor] Adult. Appendectomy / methods. Biopsy, Needle. Elective Surgical Procedures / methods. Female. Follow-Up Studies. Humans. Immunohistochemistry. Infant, Newborn. Male. Neoplasm Staging. Pregnancy. Pregnancy Trimester, Third. Radiotherapy, Adjuvant. Risk Assessment. Treatment Outcome

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  • [Copyright] Thieme Medical Publishers.
  • (PMID = 19399708.001).
  • [ISSN] 1098-8785
  • [Journal-full-title] American journal of perinatology
  • [ISO-abbreviation] Am J Perinatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 14
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90. Barry M, Collins CG, McCawley N, McGuinness J, Leahy AL: Synchronous appendiceal tumours. Surgeon; 2007 Apr;5(2):111-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Synchronous appendiceal tumours.
  • Primary appendiceal neoplasms are a rare clinical and pathological entity.
  • We report a case of synchronous appendiceal tumours of different histological types which presented as a symptomatic palpable and radiologically apparent mass in the right iliac fossa.
  • This case demonstrates the importance of pre-operative diagnosis of these neoplasms, as it may alter the surgical approach and obviate the need for additional surgery.
  • Furthermore, some of the controversies associated with the management of an appendix mass in the elderly population are discussed.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Appendiceal Neoplasms / pathology. Carcinoid Tumor / pathology. Neoplasms, Multiple Primary / pathology

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  • (PMID = 17450695.001).
  • [ISSN] 1479-666X
  • [Journal-full-title] The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
  • [ISO-abbreviation] Surgeon
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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91. Bibi R, Pranesh N, Saunders MP, Wilson MS, O'dwyer ST, Stern PL, Renehan AG: A specific cadherin phenotype may characterise the disseminating yet non-metastatic behaviour of pseudomyxoma peritonei. Br J Cancer; 2006 Nov 6;95(9):1258-64
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Pseudomyxoma peritonei (PMP) is a rare neoplasm of mainly appendiceal origin, characterised by excess intra-abdominal mucin production leading to high morbidity and mortality.
  • While histological features are frequently indolent, this tumour disseminates aggressively throughout the abdominal cavity, yet seldom metastasises.
  • [MeSH-major] Cadherins / analysis. Peritoneal Neoplasms / pathology. Pseudomyxoma Peritonei / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoembryonic Antigen / analysis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Interleukin-9 / analysis. Keratin-20 / analysis. Keratin-7 / analysis. Male. Middle Aged. Mucin-1 / analysis. Mucin-2. Mucins / analysis. Neoplasm Metastasis. Receptors, Interleukin-9 / analysis. Tumor Cells, Cultured. Vimentin / analysis

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  • (PMID = 17031402.001).
  • [ISSN] 0007-0920
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cadherins; 0 / Carcinoembryonic Antigen; 0 / Interleukin-9; 0 / Keratin-20; 0 / Keratin-7; 0 / MUC2 protein, human; 0 / Mucin-1; 0 / Mucin-2; 0 / Mucins; 0 / Receptors, Interleukin-9; 0 / Vimentin
  • [Other-IDs] NLM/ PMC2360585
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92. Beyrouti MI, Beyrouti R, Frikha F, Ben Amar M, Abid M, Ben Ameur H, Ben Salah K, Guirat A, Boujelben S: [Peritoneal gelatinous ascites]. Presse Med; 2007 Jul-Aug;36(7-8):1141-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • It most often follows a mucinous tumor of the appendix.
  • Preoperative diagnosis is facilitated by modern imaging techniques.
  • Effusion in the lesser peritoneal cavity suggests this diagnosis.
  • Magnetic resonance imaging, by showing the gelatinous ascites, their septa and the scalloping of liver and spleen, can strengthen the probability of the diagnosis.
  • Recurrence is more frequent in the forms associated with malignant or bipolar tumors.
  • [MeSH-major] Peritoneal Neoplasms / diagnosis. Peritoneal Neoplasms / therapy. Pseudomyxoma Peritonei / diagnosis. Pseudomyxoma Peritonei / therapy
  • [MeSH-minor] Aged. Antineoplastic Agents / therapeutic use. Appendectomy. Biopsy, Needle. Combined Modality Therapy. Diagnosis, Differential. Female. Humans. Hyperthermia, Induced. Laparotomy. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local / etiology. Neoplasm Recurrence, Local / therapy. Paracentesis. Preoperative Care. Rare Diseases. Survival Rate. Tomography, X-Ray Computed. Treatment Outcome. Ultrasonography

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  • (PMID = 17603922.001).
  • [ISSN] 0755-4982
  • [Journal-full-title] Presse medicale (Paris, France : 1983)
  • [ISO-abbreviation] Presse Med
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 50
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93. Järvinen P, Järvinen HJ, Lepistö A: Survival of patients with pseudomyxoma peritonei treated by serial debulking. Colorectal Dis; 2010 Sep;12(9):868-72
MedlinePlus Health Information. consumer health - Palliative Care.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PMP is a clinical condition characterized by disseminated intraperitoneal mucinous tumours often accompanied by mucinous ascites derived usually from an appendiceal neoplasm.
  • However, four patients (12%) seemed to have achieved long-term disease-free survival of more than 5 years.
  • [MeSH-major] Palliative Care / methods. Peritoneal Neoplasms / surgery. Pseudomyxoma Peritonei / surgery

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  • [CommentIn] Colorectal Dis. 2010 Sep;12(9):872-3 [20718839.001]
  • (PMID = 19519686.001).
  • [ISSN] 1463-1318
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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94. Velusamy A, Saw S, Gossage J, Bailey S, Schofield J: Combined adenocarcinoid and mucinous cystadenoma of the appendix: a case report. J Med Case Rep; 2009;3:28

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Combined adenocarcinoid and mucinous cystadenoma of the appendix: a case report.
  • INTRODUCTION: Adenocarcinoid of the appendix is a rare malignant tumour with features of both adenocarcinoma and carcinoid, showing both epithelial and endocrine differentiation.
  • Mucinous cystadenoma is the commonest of the benign neoplasms of the appendix, with an incidence of 0.6% in appendicectomy specimens.
  • Laparoscopy revealed an adenocarcinoid of the appendix in combination with mucinous cystadenoma.
  • CONCLUSION: Adenocarcinoids account for 2% of primary appendiceal malignancies.
  • Right hemicolectomy is generally advised if any of the following features are present: tumours greater than 2 cm, involvement of resection margins, greater than 2 mitoses/10 high-power fields on histology, extension of tumour beyond serosa.
  • Chemotherapy mostly with 5-Fluorouracil and Leucovorin is advised for remnant disease after surgery.

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  • (PMID = 19171048.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2647933
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95. Abdullgaffar B: Diverticulosis and diverticulitis of the appendix. Int J Surg Pathol; 2009 Jun;17(3):231-7
MedlinePlus Health Information. consumer health - Diverticulosis and Diverticulitis.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diverticulosis and diverticulitis of the appendix.
  • Diverticulosis of the appendix is a relatively rare pathological finding.
  • Appendiceal diverticulosis is usually an incidental finding and clinically asymptomatic.
  • Appendiceal diverticulitis is a distinct entity with several clinical and pathological differences from acute appendicitis.
  • Therefore, appendiceal diverticulitis should be considered in the clinical differential diagnosis, especially in adult males with chronic abdominal pain.
  • Appendiceal diverticulosis demonstrates a significant association with obstructing or incidental appendiceal neoplasms.
  • It may play an important role in the development of pseudomyxoma peritonei, which is associated with appendiceal mucinous tumors.
  • When discovered either by preoperative radiological investigations or during an exploratory operation, prophylactic appendicectomy is advocated to prevent the risk of complications and to rule out the possibility of a coexisting neoplasm.
  • [MeSH-major] Appendix / pathology. Cecal Diseases / pathology. Diverticulitis / pathology. Diverticulum / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans

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  • (PMID = 19233860.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 42
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96. Søreide K, Gudlaugsson E, Kjellevold KH: [Appendiceal mucinous cystadenoma]. Tidsskr Nor Laegeforen; 2005 Feb 3;125(3):289-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Appendiceal mucinous cystadenoma].
  • [Transliterated title] Mucinøst cystadenom i appendix.
  • BACKGROUND: Appendiceal neoplasms are rare.
  • An appendiceal mucinous neoplasia is sometimes diagnosed during a laparotomy performed on another indication.
  • The appendectomy specimen revealed a mucinous cystadenoma with a diverticulum in the appendix.
  • RESULTS AND INTERPRETATION: Appendiceal tumours account for less than 0.4% of neoplasias in the gastrointestinal tract and are found in less than 1% of appendectomies.
  • A radically removed appendix is curative in most cases of mucinous cystadenoma, whereas right hemicolectomy should be considered for patients with malignant mucinous lesions of the appendix.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Cystadenoma, Mucinous / pathology. Ovarian Neoplasms / pathology
  • [MeSH-minor] Appendectomy. Appendicitis / diagnosis. Appendicitis / surgery. Diagnosis, Differential. Female. Humans

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  • (PMID = 15702149.001).
  • [ISSN] 0807-7096
  • [Journal-full-title] Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række
  • [ISO-abbreviation] Tidsskr. Nor. Laegeforen.
  • [Language] nor
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Norway
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97. Chatelain D, Brevet M, Fuks D, Yzet T, Verhaeghe P, Regimbeau JM, Lauwers G, Sevestre H: [Inflammatory fibroid polyp, a rare tumor of the appendix]. Gastroenterol Clin Biol; 2008 Mar;32(3):274-7
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  • [Title] [Inflammatory fibroid polyp, a rare tumor of the appendix].
  • [Transliterated title] Le polype fibroïde inflammatoire, une tumeur rare de l'appendice.
  • We report the rare occurrence of an inflammatory fibroid polyp of the appendix.
  • CT-scan showed an 8 cm appendiceal mass and a laparoscopic appendectomy was consequently performed.
  • On microscopic examination, the tumor consisted of spindle cells dispersed in a loose fibromyxoid stroma containing numerous blood cells and inflammatory cells with abundant eosinophils.
  • On immunohistochemistry, the spindle tumor cells were positive for vimentin, fascin and focally for CD34 and CD35.
  • Inflammatory fibroid polyp is a rare benign mesenchymal tumor of the gastrointestinal tract rarely reported in the appendix.
  • This tumor shares some common pathologic features with the myofibroblatic inflammatory tumor but they are two different entities.
  • The pathogenesis of this tumor remains unclear but fascin and CD35 immunoreactivity of the tumor cells suggests a probable dendritic cell origin.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Intestinal Polyps / pathology. Leiomyoma / pathology

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  • (PMID = 18353580.001).
  • [ISSN] 0399-8320
  • [Journal-full-title] Gastroentérologie clinique et biologique
  • [ISO-abbreviation] Gastroenterol. Clin. Biol.
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / CR1 protein, human; 0 / Carrier Proteins; 0 / Microfilament Proteins; 0 / Receptors, Complement 3b; 0 / Vimentin; 146808-54-0 / fascin
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98. Pai RK, Beck AH, Norton JA, Longacre TA: Appendiceal mucinous neoplasms: clinicopathologic study of 116 cases with analysis of factors predicting recurrence. Am J Surg Pathol; 2009 Oct;33(10):1425-39
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Appendiceal mucinous neoplasms: clinicopathologic study of 116 cases with analysis of factors predicting recurrence.
  • The classification and nomenclature of appendiceal mucinous neoplasms are controversial.
  • To determine the outcome for patients with appendiceal mucinous neoplasms and further evaluate whether they can be stratified into groups that provide prognostic information, the clinicopathologic features of 116 patients (66 with clinical follow-up) with appendiceal mucinous neoplasms were studied.
  • From a wide variety of histopathologic features assessed, the important predictors that emerged on univariate statistical analysis were presence of extra-appendiceal neoplastic epithelium (P=0.01), high-grade cytology (P<0.0001), architectural complexity (P<0.001), and invasion (P<0.001).
  • All 16 patients with mucinous neoplasms confined to the appendix and lacking high-grade cytology, architectural complexity, and invasion were alive with no recurrences at median 59 months follow-up (=mucinous adenoma).
  • One of 14 patients with low-grade cytology and acellular peritoneal mucin deposits developed recurrent tumor within the peritoneum at 45 months with no patient deaths to date (median, 48-mo follow-up) (=low-grade mucinous neoplasm with low risk of recurrence).
  • Twenty-seven patients with low-grade mucinous neoplasms with extra-appendiceal neoplastic epithelium had 1-year, 3-year, 5-year, and 10-year overall survival rates of 96%, 91%, 79%, and 46%, respectively, at median 53 months follow-up (=low-grade mucinous neoplasm with high risk of recurrence).
  • Three of the 4 patients with extra-appendiceal epithelium limited to the right lower quadrant developed full-blown peritoneal disease at 6, 41, and 99 months follow-up and 1 patient eventually died of disease.
  • Nine patients with appendiceal neoplasms with invasion or high-grade cytology and follow-up showed 1-year, 3-year, and 5-year overall survival rates of 86%, 57%, and 28% (=mucinous adenocarcinoma).
  • Appendiceal mucinous neoplasms can be stratified into 4 distinct risk groups on the basis of a careful histopathologic assessment of cytoarchitectural features and extent of disease at presentation.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Appendiceal Neoplasms / pathology. Neoplasm Recurrence, Local / epidemiology

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  • (PMID = 19641451.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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99. Vijayaraghavan R, Chandrashekar R, Belagavi CS: Inflammatory myofibroblastic tumour of appendix. J Clin Pathol; 2006 Sep;59(9):999-1000

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Inflammatory myofibroblastic tumour of appendix.
  • [MeSH-major] Appendix / pathology. Cecal Neoplasms / pathology. Neoplasms, Muscle Tissue / pathology

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  • (PMID = 16935979.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1860482
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100. O'Brien GC, Nzewi E, Deasy J: Mucinous neoplasm of the appendix with elevated carcinoembryonic antigen. Ir Med J; 2005 Sep;98(8):240-1

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mucinous neoplasm of the appendix with elevated carcinoembryonic antigen.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Appendiceal Neoplasms / pathology

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  • (PMID = 16255116.001).
  • [ISSN] 0332-3102
  • [Journal-full-title] Irish medical journal
  • [ISO-abbreviation] Ir Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen
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