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1. Castellanos JA, Edwards CM, Shaver A, Merchant NB, Parikh AA: Appendiceal adenocarcinoma presenting as venous thromboembolism: an unusual presentation of a rare carcinoma. Am Surg; 2010 May;76(5):543-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Appendiceal adenocarcinoma presenting as venous thromboembolism: an unusual presentation of a rare carcinoma.
  • [MeSH-major] Adenocarcinoma / complications. Adenocarcinoma / diagnosis. Appendiceal Neoplasms / complications. Appendiceal Neoplasms / diagnosis. Venous Thromboembolism / etiology
  • [MeSH-minor] Humans. Male. Middle Aged. Thrombophilia / diagnosis. Thrombophilia / etiology. Thrombophilia / therapy

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  • (PMID = 20506889.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / T32 CA106183
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS619862; NLM/ PMC4157457
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2. Aljarabah MM, Borley NR, Wheeler JM: Appendiceal adenocarcinoma presenting as left-sided large bowel obstruction, a case report and literature review. Int Semin Surg Oncol; 2007;4:20

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Appendiceal adenocarcinoma presenting as left-sided large bowel obstruction, a case report and literature review.
  • BACKGROUND: appendiceal tumours are rare, they may be encountered unexpectedly in any acute or elective abdominal operation, many of these tumours are not appreciated intraoperatively and are diagnosed only during formal histopathological analysis of an appendicectomy specimen.
  • Herein we present a case of appendiceal adenocarcinoma presenting as left-sided large bowel obstruction, we also review the literature of unusual presentations of appendiceal tumours.
  • CASE PRESENTATION: we report a case of left sided large bowel obstruction found to be secondary to an appendiceal adenocarcinoma.
  • The patient presented with abdominal pain, distension and constipation, CT scan showed large bowel obstruction thought to be due to a sigmoid tumour, on laparotomy the appendix was also noted to be abnormal.
  • A separate ileocaecal resection with end ileostomy was also performed, pathology specimens showed that the primary neoplasm was the appendix with metastasis to the distal sigmoid.
  • CONCLUSION: appendiceal tumours are rare, they usually present as acute appendicitis, other presentations are far less common.

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  • (PMID = 17662117.001).
  • [ISSN] 1477-7800
  • [Journal-full-title] International seminars in surgical oncology : ISSO
  • [ISO-abbreviation] Int Semin Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1948007
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3. Mavanur AA, Parimi V, O'Malley M, Nikiforova M, Bartlett DL, Davison JM: Establishment and characterization of a murine xenograft model of appendiceal mucinous adenocarcinoma. Int J Exp Pathol; 2010 Aug;91(4):357-67
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Establishment and characterization of a murine xenograft model of appendiceal mucinous adenocarcinoma.
  • We describe the clinical, pathologic and molecular characteristics of a xenograft model of metastatic mucinous appendiceal adenocarcinoma.
  • Tumours from patients with mucinous appendiceal neoplasms were implanted in nude mice and observed for evidence of intraperitoneal tumour growth.
  • Two of seventeen implanted tumours successfully engrafted and only one mucinous adenocarcinoma propagated throughout the course of the study.
  • The cytokeratin, mucin core protein, CDX2, Ki-67 and p53 expression patterns are identical in the xenograft and resected tumour and are consistent with the expected pattern of protein expression for mucinous adenocarcinoma of the appendix.
  • Although we were unable to engraft a low-grade appendiceal mucinous neoplasm, the engrafted adenocarcinoma will be useful for future evaluation of novel therapeutic strategies directed at mucinous appendiceal adenocarcinoma and evaluation of strategies for treating widespread, bulky, mucinous peritoneal surface neoplasms.
  • Xenograft tumour enrichment can facilitate molecular studies of appendiceal epithelial neoplasia.
  • [MeSH-major] Adenocarcinoma, Mucinous / secondary. Appendiceal Neoplasms / pathology. Peritoneal Neoplasms / secondary. Xenograft Model Antitumor Assays

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  • (PMID = 20586814.001).
  • [ISSN] 1365-2613
  • [Journal-full-title] International journal of experimental pathology
  • [ISO-abbreviation] Int J Exp Pathol
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / T32 CA113263
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CDX2 protein, human; 0 / Homeodomain Proteins; 0 / KRAS protein, human; 0 / Ki-67 Antigen; 0 / Mucins; 0 / Proto-Oncogene Proteins; 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53; 68238-35-7 / Keratins; EC 3.6.5.2 / ras Proteins
  • [Other-IDs] NLM/ PMC2962894
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4. Glehen O, Gilly FN, Boutitie F, Bereder JM, Quenet F, Sideris L, Mansvelt B, Lorimier G, Msika S, Elias D, French Surgical Association: Toward curative treatment of peritoneal carcinomatosis from nonovarian origin by cytoreductive surgery combined with perioperative intraperitoneal chemotherapy: a multi-institutional study of 1,290 patients. Cancer; 2010 Dec 15;116(24):5608-18
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The principal origins of PC were colorectal adenocarcinoma (N = 523), pseudomyxoma peritonei (N = 301), gastric adenocarcinoma (N = 159), peritoneal mesothelioma (N = 88), and appendiceal adenocarcinoma (N = 50).
  • The overall median survival was 34 months; and the median survival was 30 months for patients with colorectal PC, not reached for patients with pseudomyxoma peritonei, 9 months for patients with gastric PC, 41 months for patients with peritoneal mesothelioma, and 77 months for patients with PC from appendiceal adenocarcinoma.

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  • [Copyright] Copyright © 2010 American Cancer Society.
  • (PMID = 20737573.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Investigator] Karine A; Olivier T; Catherine A; Patrick R; Philippe G; Gwenael F; Pierre M; Cecile B; Frederic M; Jacques TJ; Marc P; Rasmy L; Vincent T; Emily L; Sylvaine D; Kurt Vd
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5. Taverna G, Corinti M, Colombo P, Grizzi F, Severo M, Piccinelli A, Giusti G, Benetti A, Zucali PA, Graziotti P: Bladder metastases of appendiceal mucinous adenocarcinoma: a case presentation. BMC Cancer; 2010;10:62
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  • [Title] Bladder metastases of appendiceal mucinous adenocarcinoma: a case presentation.
  • BACKGROUND: Appendiceal adenocarcinoma is rare with a frequency of 0.08% of all surgically removed appendices.
  • Few cases of appendiceal carcinoma infiltrating the bladder wall for spatial contiguity have been documented.
  • CASE PRESENTATION: A case is reported of a 45-years old woman with mucinous cystadenocarcinoma of the appendix with bladder metastasis.
  • Histopathology of the transurethral bladder resection revealed a bladder adenocarcinoma [6 cm (at the maximum diameter) x 2,5 cm; approximate weight: 10 gr] with focal mucinous aspects penetrating the muscle and perivisceral fat.
  • Laparotomy evidenced the presence of a solid mass of the appendix (2,5 cm x 3 cm x 2 cm) extending to the loco-regional lymph nodes.
  • The subsequent pathological examination revealed a mucinous cystadenocarcinoma of the appendix with metastatic cells colonising the anterior bladder wall and several colic lymph nodes.
  • CONCLUSIONS: The rarity of the appendiceal carcinoma invading the urinary bladder and its usual involvement of nearest organs and the posterior bladder wall, led us to describe this case which demonstrates the ability of the appendiceal cancer to metastasize different regions of urinary bladder.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Cystadenocarcinoma, Mucinous / secondary. Urinary Bladder Neoplasms / secondary

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  • (PMID = 20178637.001).
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  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2836301
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6. Petrou A, Papalambros A, Katsoulas N, Bramis K, Evangelou K, Felekouras E: Primary appendiceal mucinous adenocarcinoma alongside with situs inversus totalis: a unique clinical case. World J Surg Oncol; 2010;8:49
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary appendiceal mucinous adenocarcinoma alongside with situs inversus totalis: a unique clinical case.
  • INTRODUCTION: Mucinous adenocarcinoma is a rare neoplasm of the gastrointestinal tract and one of the three major histological subtypes of the primary appendiceal adenocarcinoma.
  • The most common type of presentation is that of acute appendicitis and the diagnosis is usually occurred after appendectomy.
  • The accurate preoperative diagnosis and management of the above condition represents a real challenge when uncommon anatomic anomalies such intestinal malrotation and situs inversus take place.
  • Both preoperative US and CT scan of the abdomen and pelvis declared situs inversus, with a characteristic thickening in its wall, appendix situated in the left lower quadrant of the abdomen.
  • These findings reached to the diagnosis of acute appendicitis with situs inversus and a standard appendicectomy was performed.
  • Pathologic evaluation established primary mucinous adenocarcinoma of the appendix and three months afterwards the patient underwent a subsequent extended left hemicolectomy.
  • CONCLUSION: In conclusion, the occurrence of primary appendiceal mucinous adenocarcinoma along with situs inversus, definitely accounts as a unique clinical case.
  • Even synchronous manifestation of primary mucinous adenocarcinoma of the appendix and situs inversus totalis represents an unusual anatomo-pathological entity, all physicians should be familiar having the knowledge to make an appropriate and accurate diagnosis that will lead to prompt and correct treatment.
  • [MeSH-major] Adenocarcinoma, Mucinous / complications. Appendiceal Neoplasms / complications. Situs Inversus / complications

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  • (PMID = 20525349.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2894825
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7. Chen CF, Huang CJ, Kang WY, Hsieh JS: Experience with adjuvant chemotherapy for pseudomyxoma peritonei secondary to mucinous adenocarcinoma of the appendix with oxaliplatin/fluorouracil/leucovorin (FOLFOX4). World J Surg Oncol; 2008;6:118
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Experience with adjuvant chemotherapy for pseudomyxoma peritonei secondary to mucinous adenocarcinoma of the appendix with oxaliplatin/fluorouracil/leucovorin (FOLFOX4).
  • So far its diagnosis remains challenging to most clinicians.
  • There was a lot of mucinous ascites, one appendiceal tumor and multiple peritoneal implants disseminated from the subphrenic space to the recto-vesicle pouch.
  • Pseudomyxoma Peritonei caused by mucinous adenocarcinoma of appendiceal origin, was confirmed by histopathology.
  • We performed an excision of the appendiceal tumor combined with copious irrigation and debridement.
  • [MeSH-major] Adenocarcinoma, Mucinous / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Appendiceal Neoplasms / drug therapy. Peritoneal Neoplasms / drug therapy. Pseudomyxoma Peritonei / drug therapy

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  • (PMID = 19014441.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; 04ZR38536J / oxaliplatin; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil
  • [Other-IDs] NLM/ PMC2615010
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8. Woei Chung L, Liao YM, Hsieh CY, Lin CY: Oxaliplatin-induced long QT syndrome in a patient with appendiceal adenocarcinoma. Acta Oncol; 2009;48(1):156-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Oxaliplatin-induced long QT syndrome in a patient with appendiceal adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / drug therapy. Appendiceal Neoplasms / drug therapy. Long QT Syndrome / chemically induced. Organoplatinum Compounds / adverse effects

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  • (PMID = 18618340.001).
  • [ISSN] 1651-226X
  • [Journal-full-title] Acta oncologica (Stockholm, Sweden)
  • [ISO-abbreviation] Acta Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Norway
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; 04ZR38536J / oxaliplatin; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil
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9. Yamaguchi H, Ishimaru M, Suzuki H, Yamashita H, Hatanaka K, Uekusa T, Nagawa H: Isolated abdominal wound recurrence after lymph-node dissection for appendiceal adenocarcinoma. Am J Surg; 2010 Jan;199(1):e7-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Isolated abdominal wound recurrence after lymph-node dissection for appendiceal adenocarcinoma.
  • Postoperative histology revealed a moderately differentiated adenocarcinoma in the appendix that invaded the submucosa along with lymphatic involvement.
  • Forty-three days later, an ileocecal resection with radical lymph node dissection was performed through a midline incision.
  • Three of the 30 resected lymph nodes were found to have adenocarcinoma metastasis.
  • [MeSH-major] Abdominal Wall / pathology. Adenocarcinoma / secondary. Adenocarcinoma / surgery. Appendiceal Neoplasms / surgery. Lymph Nodes / surgery. Neoplasm Recurrence, Local / pathology
  • [MeSH-minor] Abdominal Pain / diagnosis. Abdominal Pain / etiology. Appendectomy / methods. Cicatrix / pathology. Follow-Up Studies. Humans. Immunohistochemistry. Lymph Node Excision / methods. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. Reoperation. Risk Assessment. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 19837396.001).
  • [ISSN] 1879-1883
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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10. Lee CT, Lien WC, Wang HP, Lin BR, Huang PH, Lin JT: Primary appendiceal adenocarcinoma with cecocolic intussusception. J Gastroenterol Hepatol; 2006 Jun;21(6):1079-81

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary appendiceal adenocarcinoma with cecocolic intussusception.
  • [MeSH-major] Adenocarcinoma / complications. Appendiceal Neoplasms / complications. Cecal Diseases / diagnosis. Intussusception / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 16725004.001).
  • [ISSN] 0815-9319
  • [Journal-full-title] Journal of gastroenterology and hepatology
  • [ISO-abbreviation] J. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Australia
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11. Uharcek P, Mlyncek M, Durcanský D: Appendiceal adenocarcinoma presenting with bilateral Krukenberg tumors. J Obstet Gynaecol Res; 2007 Apr;33(2):211-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Appendiceal adenocarcinoma presenting with bilateral Krukenberg tumors.
  • Primary appendiceal malignancy metastatic to the ovaries is a condition that may mimic advanced stage ovarian cancer.
  • A 52-year-old woman referred to our institution for presumed advanced stage of ovarian cancer was found to have primary appendiceal adenocarcinoma metastatic to ovaries at laparotomy.
  • It is important for the gynecologist-oncologist to include tumors of the appendix into the differential diagnosis of any case of ovarian tumor.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Krukenberg Tumor / secondary. Ovarian Neoplasms / secondary

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  • (PMID = 17441899.001).
  • [ISSN] 1341-8076
  • [Journal-full-title] The journal of obstetrics and gynaecology research
  • [ISO-abbreviation] J. Obstet. Gynaecol. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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12. Matsushita M, Ando Y, Omiya M, Uchida K, Nishio A, Okazaki K: Association of "ulcerative appendicitis" and appendiceal adenocarcinoma. Inflamm Bowel Dis; 2009 Sep;15(9):1283
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Association of "ulcerative appendicitis" and appendiceal adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / complications. Appendiceal Neoplasms / complications. Appendicitis / complications. Colitis, Ulcerative / complications
  • [MeSH-minor] Diagnosis, Differential. Humans. Mucocele / etiology

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  • [CommentOn] Inflamm Bowel Dis. 2008 Jun;14(6):873-4 [18275069.001]
  • (PMID = 18951377.001).
  • [ISSN] 1536-4844
  • [Journal-full-title] Inflammatory bowel diseases
  • [ISO-abbreviation] Inflamm. Bowel Dis.
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
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13. Siddaraju N, Soundararaghavan J, Iyengar KR: Cytology of pseudomyxoma peritonei associated with well-differentiated appendiceal adenocarcinoma. Acta Cytol; 2008 May-Jun;52(3):391-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytology of pseudomyxoma peritonei associated with well-differentiated appendiceal adenocarcinoma.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Peritoneal Neoplasms / pathology. Pseudomyxoma Peritonei / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Staining and Labeling

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  • (PMID = 18540317.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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14. Trivedi AN, Levine EA, Mishra G: Adenocarcinoma of the appendix is rarely detected by colonoscopy. J Gastrointest Surg; 2009 Apr;13(4):668-75
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenocarcinoma of the appendix is rarely detected by colonoscopy.
  • INTRODUCTION: Appendiceal tumors represent a subset of colonic neoplasms that frequently defy early diagnosis only to present at advanced stage with peritoneal metastasis.
  • The aim of this study is to determine the diagnostic yield of colonoscopy in detecting appendiceal lesions in patients with appendiceal adenocarcinoma and pseudomyxoma peritonei.
  • METHODS: We reviewed clinicopathologic data on 121 consecutive patients with histologically confirmed appendiceal adenocarcinoma with pseudomyxoma peritonei presenting to our institution for intraperitoneal hyperthermic chemotherapy (IPHC) and cytoreductive surgery between February, 1993 and August, 2007, focusing on the colonoscopy findings.
  • Abnormal findings included seven patients with appendiceal lesions (11%), 12 patients with cecal abnormalities (19%), and 28 patients with polyps (44%).
  • CONCLUSIONS: Appendiceal abnormalities are infrequently seen on colonoscopy and rarely yield a diagnostic biopsy in patients with appendiceal carcinoma.
  • We found that nearly 42% of patients with carcinoma of the appendix have synchronous colonic polyps, a much higher prevalence than would be expected, supporting a role for a perioperative colonoscopy.
  • [MeSH-major] Adenocarcinoma / diagnosis. Appendiceal Neoplasms / diagnosis. Colonoscopy. Peritoneal Neoplasms / diagnosis. Pseudomyxoma Peritonei / diagnosis

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  • (PMID = 19089515.001).
  • [ISSN] 1873-4626
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. Glehen O, Elias D, Gilly FN, Boutitie F, Bereder JM, Quenet F, Sideris L, Mansvelt B, Lorimier G, Association Française de Chirurgie: Cytoreductive surgery combined with perioperative intraperitoneal chemotherapy for the management of peritoneal carcinomatosis from digestive or primitive origin: A multi-institutional study of 1,290 patients. J Clin Oncol; 2009 May 20;27(15_suppl):4102

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The principal etiologies of PC were colorectal adenocarcinoma (N=523), pseudomyxoma peritonei (N=301), gastric adenocarcinoma (N=159), peritoneal mesothelioma (N=88), and appendiceal adenocarcinoma (N=50).
  • The overall median survival was 34 months: 30 months for colorectal PC, not reached for pseudomyxoma peritonei, 9 months for gastric PC, 41 months for peritoneal mesothelioma, and 77 months for PC from appendiceal adenocarcinoma.

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  • (PMID = 27961196.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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16. Walters KC, Paton BL, Schmelzer TS, Gersin KS, Iannitti DA, Kercher KW, Heniford BT: Treatment of appendiceal adenocarcinoma in the United States: penetration and outcomes of current guidelines. Am Surg; 2008 Nov;74(11):1066-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Treatment of appendiceal adenocarcinoma in the United States: penetration and outcomes of current guidelines.
  • Current treatment guidelines for appendiceal adenocarcinoma specify that right hemicolectomy should be performed.
  • This study evaluates appendiceal cancer outcomes in the United States and treatment guideline compliance.
  • Data for patients diagnosed with appendiceal adenocarcinoma in the Surveillance, Epidemiology, and End Results database (1988 to 2003) were analyzed.
  • The 2511 patients with appendiceal adenocarcinoma had an average age of 59.3 years, average tumor size of 4.05 cm, and 5-year survival rate of 57 per cent.
  • One-third of patients with adenocarcinoma did not undergo current surgical guideline therapy.
  • The current data raise the question of whether Stage I and II appendiceal cancer can be adequately treated with simple appendectomy.
  • [MeSH-major] Adenocarcinoma / surgery. Appendectomy. Appendiceal Neoplasms / surgery. Colectomy

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  • (PMID = 19062662.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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17. Vaira M, Scuderi S, Costamagna D, Caponi A, Caponi C, Ciaccio B, Fiorentini G, Bolieraki A, Camassa M, Parma E, Scarcello E, Taddei P, Zappelli I, De Simone M: [Cytoreduction and intraoperative peritoneal chemohyperthermia in carcinomatosis from colonic carcinoma and in peritoneal pseudomyxoma]. Suppl Tumori; 2005 May-Jun;4(3):S116

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In this study we consider the carcinomatosis from colorectal and appendiceal adenocarcinoma.
  • [MeSH-major] Carcinoma / secondary. Carcinoma / therapy. Chemotherapy, Cancer, Regional Perfusion. Colonic Neoplasms / pathology. Hyperthermia, Induced. Peritoneal Neoplasms / secondary. Peritoneal Neoplasms / therapy. Pseudomyxoma Peritonei / therapy

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  • (PMID = 16437941.001).
  • [ISSN] 2283-5423
  • [Journal-full-title] I supplementi di Tumori : official journal of Società italiana di cancerologia ... [et al.]
  • [ISO-abbreviation] Suppl Tumori
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Italy
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18. Kohashi T, Itamoto T, Yamasaki H, Yokoya H, Yonehara S, Asahara T: Sciatic hernia with an early-stage adenocarcinoma of the appendix: report of a case. Hiroshima J Med Sci; 2006 Sep;55(3):93-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sciatic hernia with an early-stage adenocarcinoma of the appendix: report of a case.
  • Sciatic hernia and early-stage appendiceal adenocarcinoma are rare disorders.
  • We report herein a case of an early stage of appendiceal adenocarcinoma found incidentally during an operation for sciatic hernia.
  • During an operation for the repair of the sciatic hernia, a deformed appendix was found incidentally and a simple appendectomy was also performed.
  • Histological examination of the excised appendix showed well-differentiated adenocarcinoma confined to the mucosal layer in a tubulo-villous adenoma.
  • [MeSH-major] Adenocarcinoma / surgery. Appendiceal Neoplasms / surgery. Herniorrhaphy

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  • (PMID = 16995495.001).
  • [ISSN] 0018-2052
  • [Journal-full-title] Hiroshima journal of medical sciences
  • [ISO-abbreviation] Hiroshima J. Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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19. Stamatakos M, Stefanaki Ch, Tsaknaki S, Safioleas P, Iannescu R, Safioleas M: Primary adenocarcinoma of the appendix: an update. Chirurgia (Bucur); 2009 Jul-Aug;104(4):389-92

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary adenocarcinoma of the appendix: an update.
  • Adenocarcinoid arising in the vermiform appendix is a rarity.
  • The diagnosis of appendiceal adenocarcinoma has never been made preoperatively and is frequently an incidental finding at the time of operation for unrelated conditions.
  • [MeSH-major] Adenocarcinoma. Appendectomy. Appendiceal Neoplasms
  • [MeSH-minor] Carcinoid Tumor / diagnosis. Carcinoid Tumor / epidemiology. Carcinoid Tumor / surgery. Humans. Incidental Findings. Prognosis. Treatment Outcome

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  • (PMID = 19886044.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
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20. Rankovic VI, Masirevic VP, Pavlov MJ, Ceranic MS, Milenkovic MG, Simic AP, Kecmanovic DM: Hemodynamic and cardiovascular problems during modified hyperthermic intraperitoneal perioperative chemotherapy. Hepatogastroenterology; 2007 Mar;54(74):364-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND/AIMS: Cytoreductive surgery and hyperthermic intraperitoneal perioperative chemotherapy (HIPEC) significantly improves patients survival with peritoneal carcinomatosis especially in low-grade tumor e.g. ovarian and appendiceal adenocarcinoma, peritoneal pseudomyxoma and grade I gastric and colorectal cancer.
  • [MeSH-major] Antineoplastic Agents / administration & dosage. Blood Pressure / physiology. Cardiac Output / physiology. Chemotherapy, Cancer, Regional Perfusion / adverse effects. Colorectal Neoplasms / drug therapy. Colorectal Neoplasms / surgery. Heart Rate / physiology. Hyperthermia, Induced / adverse effects. Ovarian Neoplasms / drug therapy. Ovarian Neoplasms / surgery. Peritoneal Neoplasms / drug therapy. Peritoneal Neoplasms / surgery. Postoperative Complications / physiopathology. Pseudomyxoma Peritonei / drug therapy. Pseudomyxoma Peritonei / surgery

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  • (PMID = 17523275.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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21. Maes M, Segers K, Cheyns P: Goblet cell carcinoid of the appendix: laparoscopic appendectomy or right hemicolectomy? Acta Chir Belg; 2008 Jul-Aug;108(4):447-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Goblet cell carcinoid of the appendix: laparoscopic appendectomy or right hemicolectomy?
  • Goblet cell carcinoids are uncommon tumours with histological features of both adenocarcinoma and carcinoid tumour.
  • They occur predominantly in the appendix and although the malignant potential remains unclear, adenocarcinoids appear to be more aggressive than conventional carcinoids.
  • Macroscopically, a diffusely inflamed appendix was found with no sign of perforation.
  • As they may present the same clinical presentation, pathological diagnosis is required to distinguish goblet cell carcinoid from acute appendicitis.
  • Two-stage surgery for goblet cell carcinoid is advocated in the literature, but the debate still continues as to whether the goblet cell carcinoid should be treated by appendectomy alone, as for most carcinoids, or by right hemicolectomy, as for the appendiceal adenocarcinoma.
  • [MeSH-major] Appendectomy / methods. Appendiceal Neoplasms / surgery. Carcinoid Tumor / surgery. Colectomy / methods. Laparoscopy / methods
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Follow-Up Studies. Humans

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  • (PMID = 18807600.001).
  • [ISSN] 0001-5458
  • [Journal-full-title] Acta chirurgica Belgica
  • [ISO-abbreviation] Acta Chir. Belg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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22. Suzuki J, Kazama S, Kitayama J, Uozaki H, Miyata T, Nagawa H: Signet ring cell carcinoma of the appendix manifesting as colonic obstruction and ovarian tumors: report of a case. Surg Today; 2009;39(3):235-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Signet ring cell carcinoma of the appendix manifesting as colonic obstruction and ovarian tumors: report of a case.
  • Appendiceal cancer is rare and associated with a poor prognosis because it is usually found at an advanced stage.
  • We report a case of appendiceal adenocarcinoma manifesting as a colonic obstruction with a lower abdominal mass.
  • Laparotomy revealed bilateral ovarian tumors and a small appendiceal tumor with peritoneal metastases.
  • We performed ileocecal resection, colectomy, and oophorectomy, following which a histological diagnosis of signet ring cell carcinoma was made.
  • Immunohistochemical analysis revealed positive expression of cytokeratin 7 and 20, and mucin core protein 2 (MUC2), compatible with appendiceal cancer and Kruckenberg metastases.
  • When a patient is found to have disseminated pelvic signet ring cell carcinoma of unknown origin, the appendix should be considered as a possible primary site.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Carcinoma, Signet Ring Cell / pathology. Intestinal Obstruction / etiology. Ovarian Neoplasms / pathology
  • [MeSH-minor] Aged. Biomarkers / analysis. Female. Humans. Magnetic Resonance Imaging. Peritoneal Neoplasms / diagnosis. Peritoneal Neoplasms / secondary. Peritoneal Neoplasms / surgery. Tomography, X-Ray Computed


23. Tran TA, Holloway RW, Finkler NJ: Metastatic appendiceal mucinous adenocarcinoma to well-differentiated diffuse mesothelioma of the peritoneal cavity: a mimicker of florid mesothelial hyperplasia in association with neoplasms. Int J Gynecol Pathol; 2008 Oct;27(4):526-30
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  • [Title] Metastatic appendiceal mucinous adenocarcinoma to well-differentiated diffuse mesothelioma of the peritoneal cavity: a mimicker of florid mesothelial hyperplasia in association with neoplasms.
  • The subsequent operation, however, demonstrated a mucinous neoplasm of the appendix with involvement of the peritoneal cavity in the form of peritoneal mucinous carcinomatosis as well as metastases to the uterine serosa and adnexal surfaces.
  • Microscopic analysis revealed an appendiceal adenocarcinoma with signet-ring-cell features that has metastasized to a diffuse well-differentiated mesothelioma of the peritoneal cavity.
  • To the best of our knowledge, this is the first report of a metastatic appendiceal mucinous adenocarcinoma to a well-differentiated diffuse mesothelioma of the peritoneal cavity.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Appendiceal Neoplasms / pathology. Mesothelioma / pathology. Peritoneal Neoplasms / secondary
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Histocytochemistry. Humans

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  • (PMID = 18753969.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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24. Varghese S, Burness M, Xu H, Beresnev T, Pingpank J, Alexander HR: Site-specific gene expression profiles and novel molecular prognostic factors in patients with lower gastrointestinal adenocarcinoma diffusely metastatic to liver or peritoneum. Ann Surg Oncol; 2007 Dec;14(12):3460-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Site-specific gene expression profiles and novel molecular prognostic factors in patients with lower gastrointestinal adenocarcinoma diffusely metastatic to liver or peritoneum.
  • BACKGROUND: Generally, colorectal and high-grade appendiceal cancers are treated similarly; treatment approach is primarily based on tumor histology and stage of disease.
  • Patients with adenocarcinoma of the lower gastrointestinal tract frequently experience diffuse metastases isolated to liver or peritoneum and have a poor survival.
  • METHODS: Microarray analyses of 20 metastatic tumors from patients with colorectal adenocarcinoma isolated to liver or peritoneum and eight high-grade appendiceal adenocarcinoma metastatic to peritoneum were performed using oligonucleotide microarray.
  • Subsets of genes significantly associated with poor survival were defined, a RET proto-oncogene interacting gene, GOLGA5, was highly predictive for survival in patients with colorectal adenocarcinoma.
  • CONCLUSIONS: These results demonstrate that liver and peritoneal metastases of lower GI adenocarcinoma have distinct gene expression patterns; these distinctions may help in the development of therapies based on site of metastases.
  • [MeSH-major] Adenocarcinoma / genetics. Biomarkers, Tumor / genetics. Colorectal Neoplasms / genetics. Gene Expression Profiling. Liver Neoplasms / genetics

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  • (PMID = 17899288.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / RNA, Messenger
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25. Shinji A, Mukawa K, Nokubi M, Ohta H, Mochizuki T, Okiyama W, Yamamura N, Oguchi H, Nakamura T, Hamano H: Missed appendiceal adenocarcinoma diagnosed preoperatively by endoscopy with an attached transparent hood. Gastrointest Endosc; 2009 Mar;69(3 Pt 2):761-2; discussion 762

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Missed appendiceal adenocarcinoma diagnosed preoperatively by endoscopy with an attached transparent hood.
  • [MeSH-major] Adenocarcinoma / diagnosis. Appendiceal Neoplasms / diagnosis. Endoscopy, Gastrointestinal

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  • (PMID = 19251025.001).
  • [ISSN] 1097-6779
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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26. Hsu JT, Chen HM, Liao CH, Yeh CN, Yeh TS, Hwang TL, Jan YY, Chen MF: Clinicopathologic features and predictors for survival of mucinous and non-mucinous appendiceal adenocarcinoma. Dig Surg; 2008;25(5):369-75

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinicopathologic features and predictors for survival of mucinous and non-mucinous appendiceal adenocarcinoma.
  • BACKGROUND/AIMS: We report a study in patients with mucinous and non-mucinous appendiceal adenocarcinoma treated surgically whose records were examined to elucidate their clinicopathologic features and prognostic factors for survival.
  • METHODS: The medical records of 34 patients with mucinous and non-mucinous appendiceal adenocarcinoma (1991-2005) were retrospectively reviewed.
  • The overall 5-year survival rate for 34 patients with appendiceal adenocarcinoma was 35.8%.
  • CONCLUSION: Mucinous appendiceal adenocarcinoma had clinicopathologic characteristics and a prognosis similar to non-mucinous, except that there was more leukocytosis in non-mucinous tumors.
  • Tumor stage is an independent predictor for survival among patients with appendiceal adenocarcinoma.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Appendiceal Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Adult. Aged. Aged, 80 and over. Analysis of Variance. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Appendectomy / methods. Biopsy. Chemotherapy, Adjuvant. Female. Follow-Up Studies. Humans. Male. Medical Records. Middle Aged. Multivariate Analysis. Neoplasm Staging. Postoperative Care. Predictive Value of Tests. Prognosis. Retrospective Studies. Risk Factors. Survival Analysis

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  • (PMID = 19005255.001).
  • [ISSN] 1421-9883
  • [Journal-full-title] Digestive surgery
  • [ISO-abbreviation] Dig Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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27. Umemoto M, Shiota M, Shimaoka M, Hoshiai H: Definitive diagnosis of primary adenocarcinoma of the appendix by laparoscopic appendectomy. J Obstet Gynaecol Res; 2007 Aug;33(4):590-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Definitive diagnosis of primary adenocarcinoma of the appendix by laparoscopic appendectomy.
  • We report a 62-year-old woman with a primary adenocarcinoma of the appendix mimicking ovarian tumor.
  • However, the present case suggests that, in some cases, if cancer of the appendix can be diagnosed early, laparotomy can be avoided and the cancer treated with minimally invasive laparoscopic surgery alone.
  • [MeSH-major] Adenocarcinoma / pathology. Appendiceal Neoplasms / pathology

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  • (PMID = 17688638.001).
  • [ISSN] 1341-8076
  • [Journal-full-title] The journal of obstetrics and gynaecology research
  • [ISO-abbreviation] J. Obstet. Gynaecol. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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28. Ko YH, Park SH, Jung CK, Won HS, Hong SH, Park JC, Roh SY, Woo IS, Kang JH, Hong YS, Byun JH: Clinical characteristics and prognostic factors for primary appendiceal carcinoma. Asia Pac J Clin Oncol; 2010 Mar;6(1):19-27

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical characteristics and prognostic factors for primary appendiceal carcinoma.
  • AIM: Primary adenocarcinoma of the appendix is a rare malignancy.
  • This study assessed prognostic factors affecting the clinical outcome in patients with appendiceal neoplasms.
  • Of the 34 patients who underwent curative resections of primary appendiceal carcinomas, the 3- and 5-year disease-free survival rates were 66.4% and 53.3%, respectively.
  • CONCLUSION: High tumor grade and advanced stage were significantly predictive of poor survival outcome in patients with primary appendiceal carcinomas.
  • [MeSH-major] Adenocarcinoma / pathology. Appendiceal Neoplasms / pathology

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  • (PMID = 20398034.001).
  • [ISSN] 1743-7563
  • [Journal-full-title] Asia-Pacific journal of clinical oncology
  • [ISO-abbreviation] Asia Pac J Clin Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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29. Kunz J, Makek M: [Primary adenocarcinoma of the appendix as differential diagnosis of advanced ovarian carcinoma]. Praxis (Bern 1994); 2006 Aug 16;95(33):1217-25
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Primary adenocarcinoma of the appendix as differential diagnosis of advanced ovarian carcinoma].
  • [Transliterated title] Das primäre Adenokarzinom der Appendix als Differentialdiagnose des fortgeschrittenen Ovarialkarzinoms.
  • Malignant tumours of the appendix are rare.
  • Metastatic mucinous adenocarcinomas of the appendix are only reported as case histories.
  • Advanced primary adenocarcinomas of the appendix with ovarian metastases cannot be distinguished intraoperatively from a FIGO III ovarian carcinoma.
  • The pathologist makes the definitive diagnosis.
  • Surgical therapy of the isolated primary appendiceal carcinoma consists of a hemicolectomy--an appendectomy in favourable cases--and, in the case of a metastasised carcinoma, according to the guidelines for an advanced ovarian or colon carcinoma.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Adenocarcinoma, Mucinous / secondary. Appendiceal Neoplasms / diagnosis. Carcinoma, Signet Ring Cell / diagnosis. Carcinoma, Signet Ring Cell / secondary. Ovarian Neoplasms / diagnosis. Ovarian Neoplasms / secondary
  • [MeSH-minor] Appendix / pathology. Appendix / surgery. Diagnosis, Differential. Female. Humans. Hysterectomy, Vaginal. Middle Aged. Omentum / pathology. Omentum / surgery. Ovary / pathology. Ovary / surgery. Peritoneal Neoplasms / diagnosis. Peritoneal Neoplasms / pathology. Peritoneal Neoplasms / secondary. Peritoneal Neoplasms / surgery. Peritoneum / pathology. Peritoneum / surgery. Postoperative Complications / diagnosis. Postoperative Complications / pathology. Postoperative Complications / surgery. Reoperation

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  • (PMID = 16939122.001).
  • [ISSN] 1661-8157
  • [Journal-full-title] Praxis
  • [ISO-abbreviation] Praxis (Bern 1994)
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Switzerland
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30. Nishio R, Furuya Y, Akashi T, Okumura A, Fuse H: Primary adenocarcinoma of the appendix invading the urinary bladder. Int Urol Nephrol; 2006;38(3-4):481-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary adenocarcinoma of the appendix invading the urinary bladder.
  • We report a case of adenocarcinoma of the appendix invading the urinary bladder in a 75-year-old man.
  • At operation a primary neoplasm of the appendix invading the bladder was discovered and en bloc resection of the urinary bladder with the adherent cecum followed by an ileocolonic anastomosis and ureterocutaneostomy was performed.
  • [MeSH-major] Adenocarcinoma / pathology. Appendiceal Neoplasms / pathology. Urinary Bladder Neoplasms / pathology

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  • [Cites] Br J Urol. 1996 Aug;78(2):305-6 [8813936.001]
  • [Cites] J Urol. 1995 Apr;153(4):1220-1 [7869505.001]
  • [Cites] Cancer. 1976 May;37(5):2493-510 [1260730.001]
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  • [Cites] Hinyokika Kiyo. 2002 Jun;48(6):351-4 [12166235.001]
  • (PMID = 17160444.001).
  • [ISSN] 0301-1623
  • [Journal-full-title] International urology and nephrology
  • [ISO-abbreviation] Int Urol Nephrol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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31. Villanueva Saenz E, Pérez-Aguirre J, Belmonte MC, Martínez PH, Márquez RM, Carranza RJ: Appendix adenocarcinoma associated with ulcerative colitis: a case report and literature review. Tech Coloproctol; 2006 Mar;10(1):54-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Appendix adenocarcinoma associated with ulcerative colitis: a case report and literature review.
  • Ulcerative colitis (UC) represents a risk factor for colorectal cancer, but the association between UC and appendix cancer is uncommon.
  • Histopathological analysis indicated adenocarcinoma from the cecal appendix, and chronic-active ulcerative colitis of the colon.
  • The appendix adenocarcinoma and ulcerative colitis may or may not be associated, same as colon cancer in patients with UC.
  • [MeSH-major] Adenocarcinoma / etiology. Appendiceal Neoplasms / etiology. Colitis, Ulcerative / complications

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  • (PMID = 16528481.001).
  • [ISSN] 1123-6337
  • [Journal-full-title] Techniques in coloproctology
  • [ISO-abbreviation] Tech Coloproctol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 8
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32. Manigrasso A, Candioli S, Pironi D, La Torre V, Panarese A, Romani AM, Arcieri S, Tarroni D, Palazzini G, Filippini A: [Adenocarcinoma of the appendix. A case report and review of the literature]. G Chir; 2007 Mar;28(3):73-81

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Adenocarcinoma of the appendix. A case report and review of the literature].
  • [Transliterated title] L'adenocarcinoma dell'appendice ileo-ciecale: presentazione di un caso clinico e revisione della letteratura.
  • Primary adenocarcinoma of the appendix is a rare malignancy that constitutes less than 0.5% of all gastrointestinal neoplasms.
  • Usually the diagnosis is made only after histological examination of surgically removed inflamed appendix.
  • Alternatively represent an unexpected finding, confirmed by frozen section, during surgery performed for acute appendicitis or other non appendiceal pathologies.
  • Natural history is strongly influenced by anatomic peculiarities of the appendix that predispose to early spread and perforation.
  • The correct management is the right hemicolectomy as a primary procedure in the case of preoperatively or intraoperatively diagnosis or as secondary procedure, after two-three weeks from appendectomy, when the microscopic examination of specimen reveals the presence of adenocarcinoma.
  • The Authors report a case of primary adenocarcinoma of the appendix occurred in a 78 year-old female patient, diagnosed incidentally during surgery performed for ileus from suspected cecal neoplasm.
  • [MeSH-major] Appendiceal Neoplasms. Carcinoma, Signet Ring Cell

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  • (PMID = 17419903.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 36
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33. Logan-Collins JM, Lowy AM, Robinson-Smith TM, Kumar S, Sussman JJ, James LE, Ahmad SA: VEGF expression predicts survival in patients with peritoneal surface metastases from mucinous adenocarcinoma of the appendix and colon. Ann Surg Oncol; 2008 Mar;15(3):738-44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] VEGF expression predicts survival in patients with peritoneal surface metastases from mucinous adenocarcinoma of the appendix and colon.
  • BACKGROUND: High levels of vascular endothelial growth factor (VEGF) in ovarian cancer metastases are associated with a worse prognosis in patients treated with chemotherapy.
  • VEGF-directed therapy improves survival for those with metastatic colorectal cancer.
  • We hypothesized that angiogenic indices may be prognostic in patients undergoing cytoreductive surgery for mucinous adenocarcinoma of the appendix and colon.
  • CD 34 counts (blood vessels) and VEGF expression was evaluated by means of immunohistochemistry on specimens from patients undergoing cytoreductive surgery and intraperitoneal hyperthermic perfusion (IPHP) for mucinous adenocarcinoma.
  • RESULTS: A total of 26 males and 9 females, with a mean age of 50 years, underwent cytoreductive surgery and IPHP for mucinous adenocarcinoma of appendiceal (n = 32) or colonic (n = 3) origin.
  • CONCLUSIONS: These results suggest that markers of tumor angiogenesis may predict survival in patients with peritoneal surface metastases from mucinous adenocarcinoma.
  • [MeSH-major] Adenocarcinoma, Mucinous / metabolism. Adenocarcinoma, Mucinous / therapy. Appendiceal Neoplasms / pathology. Appendiceal Neoplasms / therapy. Biomarkers, Tumor / biosynthesis. Peritoneal Neoplasms / metabolism. Peritoneal Neoplasms / therapy. Vascular Endothelial Growth Factor A / biosynthesis

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  • (PMID = 18043973.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A
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34. Bozanović T, Ljubić A, Momcilov P, Mostić T, Vojvodić L, Vidaković S: Synchronous primary tumors: appendiceal and ovarian cancer--case report. Eur J Gynaecol Oncol; 2009;30(2):237-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Synchronous primary tumors: appendiceal and ovarian cancer--case report.
  • A 64-year-old women was operated on for acute abdomen and both appendiceal and ovarian tumors were found.
  • Histology revealed synchronous adenocarcinoma of the appendix and serous pappillary carcinoma of the right ovary.
  • A rare case of synchronous primary tumors of appendiceal and ovarian origin is reported.
  • [MeSH-major] Adenocarcinoma / pathology. Appendiceal Neoplasms / pathology. Carcinoma, Papillary / pathology. Neoplasms, Multiple Primary / pathology. Ovarian Neoplasms / pathology

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  • (PMID = 19480268.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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35. Sugarbaker PH, Bijelic L, Chang D, Yoo D: Neoadjuvant FOLFOX chemotherapy in 34 consecutive patients with mucinous peritoneal carcinomatosis of appendiceal origin. J Surg Oncol; 2010 Nov 1;102(6):576-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Neoadjuvant FOLFOX chemotherapy in 34 consecutive patients with mucinous peritoneal carcinomatosis of appendiceal origin.
  • BACKGROUND: A treatment option for patients with peritoneal mucinous carcinomatosis (PMCA) from an appendiceal neoplasm is cytoreductive surgery and perioperative intraperitoneal chemotherapy.
  • METHODS: In January of 2005 a prospective study was initiated to routinely treat patients with peritoneal dissemination of a mucinous adenocarcinoma of the appendix with neoadjuvant chemotherapy using FOLFOX.
  • [MeSH-major] Adenocarcinoma, Mucinous / drug therapy. Adenocarcinoma, Mucinous / secondary. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Appendiceal Neoplasms / pathology. Peritoneal Neoplasms / drug therapy. Peritoneal Neoplasms / secondary

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  • (PMID = 20737420.001).
  • [ISSN] 1096-9098
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; Folfox protocol
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36. Misdraji J: Appendiceal mucinous neoplasms: controversial issues. Arch Pathol Lab Med; 2010 Jun;134(6):864-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Appendiceal mucinous neoplasms: controversial issues.
  • Low grade appendiceal mucinous neoplasms can spread to the peritoneum as pseudomyxoma peritonei even though they are not obviously invasive in the appendix.
  • During the past several decades, several problematic issues surrounding this enigmatic tumor have been debated in the literature, including appropriate nomenclature for the appendiceal tumors and their peritoneal metastases.
  • In this article, the most contentious issues in the area of appendiceal mucinous tumors are examined.
  • First, the classification systems that have been proposed for these tumors are compared in the context of whether the appendiceal mucinous tumors are ruptured adenomas or invasive carcinomas.
  • Next reviewed is the largely resolved controversy about whether ovarian mucinous tumors in this setting are separate primaries or are metastases from the appendiceal tumor.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Appendiceal Neoplasms / diagnosis. Pseudomyxoma Peritonei / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Ovarian Neoplasms / diagnosis. Ovarian Neoplasms / pathology. Ovarian Neoplasms / secondary. Peritoneal Neoplasms / diagnosis. Peritoneal Neoplasms / secondary. Peritoneal Neoplasms / therapy

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  • (PMID = 20524864.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 36
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37. Hsu M, Young RH, Misdraji J: Ruptured appendiceal diverticula mimicking low-grade appendiceal mucinous neoplasms. Am J Surg Pathol; 2009 Oct;33(10):1515-21

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ruptured appendiceal diverticula mimicking low-grade appendiceal mucinous neoplasms.
  • Low-grade appendiceal mucinous neoplasms may rupture and seed the peritoneum with bland neoplastic mucinous epithelium resulting, when grossly evident, in the well-known process pseudomyxoma peritonei.
  • Appendiceal diverticula may also rupture, resulting in mucin on the appendiceal serosa, which may raise concern for an underlying appendiceal mucinous neoplasm.
  • We report 11 cases of ruptured appendiceal diverticula that were initially either misdiagnosed as appendiceal mucinous neoplasms, raised concern for a neoplasm, or were thought to exhibit localized pseudomyxoma peritonei.
  • Two cases showed eversion of the appendiceal lining onto the serosa; 1 showed collision between the diverticulum and endosalpingiosis, and 3 had rare nonneoplastic epithelial cells in extra-appendiceal mucin.
  • Pathologists should be aware that ruptured appendiceal diverticula may be associated with serosal mucin and even extra-appendiceal epithelium.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Appendiceal Neoplasms / pathology. Appendix / pathology. Cecal Diseases / pathology. Diverticulum / pathology
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Rupture, Spontaneous

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  • (PMID = 19623035.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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38. Goere D, Elias D: [Appendiceal tumors found at appendectomy]. J Chir (Paris); 2009 Oct;146 Spec No 1:36-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Appendiceal tumors found at appendectomy].
  • [Transliterated title] Diagnostic de tumeur appendiculaire lors d'une appendicectomie.
  • There are three main histologic types of appendiceal tumor: adenoma, adenocarcinoma, and neuroendocrine tumor.
  • Neuroendocrine tumors (carcinoids) are by far the most common and account for two-third of all appendiceal tumors.
  • For unruptured appendiceal tumor, the appendix should be removed by a carcinologic right hemicolectomy if the tumor appears aggressive.
  • [MeSH-major] Appendectomy. Appendiceal Neoplasms / surgery
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / surgery. Adenoma / diagnosis. Adenoma / surgery. Humans. Neuroendocrine Tumors / diagnosis. Neuroendocrine Tumors / surgery. Peritoneal Neoplasms / prevention & control. Pseudomyxoma Peritonei / prevention & control. Rupture / prevention & control

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  • (PMID = 19846099.001).
  • [ISSN] 0021-7697
  • [Journal-full-title] Journal de chirurgie
  • [ISO-abbreviation] J Chir (Paris)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 7
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39. Barry M, Collins CG, McCawley N, McGuinness J, Leahy AL: Synchronous appendiceal tumours. Surgeon; 2007 Apr;5(2):111-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Synchronous appendiceal tumours.
  • Primary appendiceal neoplasms are a rare clinical and pathological entity.
  • We report a case of synchronous appendiceal tumours of different histological types which presented as a symptomatic palpable and radiologically apparent mass in the right iliac fossa.
  • This case demonstrates the importance of pre-operative diagnosis of these neoplasms, as it may alter the surgical approach and obviate the need for additional surgery.
  • Furthermore, some of the controversies associated with the management of an appendix mass in the elderly population are discussed.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Appendiceal Neoplasms / pathology. Carcinoid Tumor / pathology. Neoplasms, Multiple Primary / pathology

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  • (PMID = 17450695.001).
  • [ISSN] 1479-666X
  • [Journal-full-title] The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
  • [ISO-abbreviation] Surgeon
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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40. Hu CC, Chang JJ, Chen TC, Yen CL, Chien RN: Colonoscopic feature of primary adenocarcinoma of the appendix:. Intern Med; 2008;47(4):255-7
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  • [Title] Colonoscopic feature of primary adenocarcinoma of the appendix:.
  • We herein report a case of primary adenocarcinoma of the appendix, a very rare disease that is seldom diagnosed before surgical intervention.
  • This case was first suspected for its unique colonoscopic presentation as a cecal submucosal tumor with an overlying mucin-coat at the appendiceal orifice.
  • The diagnosis was later confirmed after the operation.
  • [MeSH-major] Adenocarcinoma / pathology. Appendix. Cecal Neoplasms / pathology. Colonoscopy

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  • (PMID = 18277025.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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41. Yantiss RK, Shia J, Klimstra DS, Hahn HP, Odze RD, Misdraji J: Prognostic significance of localized extra-appendiceal mucin deposition in appendiceal mucinous neoplasms. Am J Surg Pathol; 2009 Feb;33(2):248-55
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prognostic significance of localized extra-appendiceal mucin deposition in appendiceal mucinous neoplasms.
  • Appendiceal mucinous neoplasms confined to the mucosa are benign, whereas those with disseminated peritoneal mucin deposits often follow an indolent, but malignant, course.
  • Not infrequently, appendiceal mucinous neoplasms are associated with localized periappendiceal mucin deposits, but lack diffuse peritoneal involvement.
  • Although some investigators consider both acellular and cellular periappendiceal mucin to pose no, or minimal, risk for recurrent disease, the biologic importance of localized extra-appendiceal mucin has never been evaluated.
  • We identified 65 patients with appendiceal mucinous neoplasms, all of whom had localized periappendiceal mucin deposits without diffuse peritoneal involvement, and assessed them for the presence of extra-appendiceal epithelium and clinical outcome.
  • Most (77%) cases showed acellular periappendiceal mucin, but 15 (23%) had scant extra-appendiceal epithelium (range: 1 to 12 cell clusters).
  • Thus, patients with appendiceal mucinous neoplasms and acellular periappendiceal mucin are unlikely to develop recurrent disease.
  • However, microscopic examination of the entire appendix is necessary, as lesions with extra-appendiceal tumor cells are more likely to progress to disseminated disease and result in death of the patient, even if the mucin is paucicellular and confined to the periappendiceal region.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Appendiceal Neoplasms / pathology. Mucins / metabolism

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  • (PMID = 18852679.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Mucins
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42. Topkan E, Polat Y, Karaoglu A: Primary mucinous adenocarcinoma of appendix treated with chemotherapy and radiotherapy: a case report. Tumori; 2008 Jul-Aug;94(4):596-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary mucinous adenocarcinoma of appendix treated with chemotherapy and radiotherapy: a case report.
  • A rare case of primary appendiceal mucinous adenocarcinoma is reported.
  • An appendectomy was performed resulting in a histological diagnosis of grade 2 mucinous adenocarcinoma of the appendix.
  • [MeSH-major] Adenocarcinoma, Mucinous / drug therapy. Adenocarcinoma, Mucinous / radiotherapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Appendiceal Neoplasms / drug therapy. Appendiceal Neoplasms / radiotherapy. Colectomy

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  • (PMID = 18822701.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; 04ZR38536J / oxaliplatin; 0W860991D6 / Deoxycytidine; 6804DJ8Z9U / Capecitabine; U3P01618RT / Fluorouracil
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43. Griniatsos J, Michail O: Appendiceal neuroendocrine tumors: Recent insights and clinical implications. World J Gastrointest Oncol; 2010 Apr 15;2(4):192-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Appendiceal neuroendocrine tumors: Recent insights and clinical implications.
  • New insights emerged last decade that enriched our knowledge regarding the biological behavior of appendiceal neuroendocrine tumors (NETs), which range from totally benign tumors less than 1cm to goblet cell carcinomas which behave similarly to colorectal adenocarcinoma.
  • Since the diagnosis is usually established post-appendicectomy, current recommendations focus on the early detection of:.
  • (2) the recurrence based on the chromogranin a plasma levels; and (3) other malignancies which are commonly developed in patients with appendiceal NETs.

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  • (PMID = 21160597.001).
  • [ISSN] 1948-5204
  • [Journal-full-title] World journal of gastrointestinal oncology
  • [ISO-abbreviation] World J Gastrointest Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2999180
  • [Keywords] NOTNLM ; Appendiceal carcinoids / Goblet cell carcinoma / Neuroendocrine tumors / Right hemicolectomy
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44. Tucker ON, Madhavan P, Healy V, Jeffers M, Keane FB: Unusual presentation of an appendiceal malignancy. Int Surg; 2006 Jan-Feb;91(1):57-60

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Unusual presentation of an appendiceal malignancy.
  • Primary malignant epithelial tumors of the appendix are uncommon.
  • The most common presentation of appendiceal malignancy is right lower abdominal pain suggestive of acute appendicitis.
  • We present the case of a 48-year-old woman with an appendiceal malignancy who presented with symptoms and signs suggestive of complicated diverticular disease with an enterovaginal fistula.
  • From a review of the literature, this is the first report of an appendiceal malignancy presenting in this manner.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Appendiceal Neoplasms / diagnosis
  • [MeSH-minor] Diverticulitis / diagnosis. Female. Humans. Intestinal Fistula / diagnosis. Middle Aged. Tomography, X-Ray Computed. Vaginal Fistula / diagnosis

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  • (PMID = 16706105.001).
  • [ISSN] 0020-8868
  • [Journal-full-title] International surgery
  • [ISO-abbreviation] Int Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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45. Pai RK, Longacre TA: Appendiceal mucinous tumors and pseudomyxoma peritonei: histologic features, diagnostic problems, and proposed classification. Adv Anat Pathol; 2005 Nov;12(6):291-311
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Appendiceal mucinous tumors and pseudomyxoma peritonei: histologic features, diagnostic problems, and proposed classification.
  • In recent years, this condition has been convincingly linked to appendiceal mucinous neoplasms, yet there has been insufficient attention to the histologic characteristics, classification, and differential diagnostic considerations of these neoplasms when encountered by the surgical pathologist.
  • This review provides a coherent approach to the diagnosis and classification of appendiceal mucinous tumors and the peritoneal implants associated with the pseudomyxoma peritonei syndrome with emphasis on differential diagnostic considerations and recommendations for the final pathology report.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Appendiceal Neoplasms / pathology. Peritoneal Neoplasms / pathology. Pseudomyxoma Peritonei / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans

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  • (PMID = 16330927.001).
  • [ISSN] 1072-4109
  • [Journal-full-title] Advances in anatomic pathology
  • [ISO-abbreviation] Adv Anat Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 69
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46. Gupta S, Parsa V, Adsay V, Heilbrun LK, Smith D, Shields AF, Weaver D, Philip PA, El-Rayes BF: Clinicopathological analysis of primary epithelial appendiceal neoplasms. Med Oncol; 2010 Dec;27(4):1073-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinicopathological analysis of primary epithelial appendiceal neoplasms.
  • Appendiceal carcinomas are classified into three distinct histopathological disease entities: disseminated peritoneal adenomucinosis (DPAM), peritoneal mucinous carcinomatosis (PMCA), or peritoneal mucinous carcinomatosis with intermediate or discorant features (PMCA I/D).
  • The treatment of appendiceal tumors should be based on accurate histopathological classification, per previously reported case series.
  • The objective of this study was to evaluate the clinicopathologic presentation and outcome of patients with appendiceal tumors treated at our institution over a 15-year period.
  • We identified patients with appendiceal tumors diagnosed or treated at our institution from January 1989 through May 2004.
  • Chart review for age, gender, signs and symptoms at diagnosis, and treatment was performed.
  • Three distinct histopathological disease entities exist in appendiceal tumors.
  • The prognosis and management of these tumors should be based on the extent of disease and pathologic diagnosis.

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  • [Cites] Ann Surg Oncol. 2005 Jan;12(1):72-80 [15827781.001]
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  • (PMID = 19851895.001).
  • [ISSN] 1559-131X
  • [Journal-full-title] Medical oncology (Northwood, London, England)
  • [ISO-abbreviation] Med. Oncol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P30 CA022453; United States / NCI NIH HHS / CA / CA-22453
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS513798; NLM/ PMC3883058
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47. Feo CF, Porcu A, Scanu AM, Ginesu GC, Fancellu A, Lorettu A, Dettori G: Primary appendiceal tumors: report on 10 cases. Int Surg; 2009 Jul-Sep;94(3):224-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary appendiceal tumors: report on 10 cases.
  • We report our experience on 10 patients with primary tumors of the appendix treated at our institution from 1998 to 2005.
  • Two of the four patients with benign tumors died from causes unrelated to the appendiceal neoplasm.
  • Despite the rarity of appendiceal primary tumors, surgeons should be aware of these neoplasms for making correct treatment decisions.
  • We stress the importance of laparoscopic exploration in the management of appendiceal masses.
  • [MeSH-major] Adenocarcinoma / surgery. Appendiceal Neoplasms / surgery. Carcinoid Tumor / surgery

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  • (PMID = 20187516.001).
  • [ISSN] 0020-8868
  • [Journal-full-title] International surgery
  • [ISO-abbreviation] Int Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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48. Ko YH, Jung CK, Oh SN, Kim TH, Won HS, Kang JH, Kim HJ, Kang WK, Oh ST, Hong YS: Primary signet ring cell carcinoma of the appendix: a rare case report and our 18-year experience. World J Gastroenterol; 2008 Oct 7;14(37):5763-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary signet ring cell carcinoma of the appendix: a rare case report and our 18-year experience.
  • Primary adenocarcinoma of the appendix is a rare malignancy that constitutes < 0.5% of all gastrointestinal neoplasms.
  • Moreover, primary signet ring cell carcinoma of the appendix is an exceedingly rare entity.
  • We have encountered 15 cases of primary appendiceal cancer among 3389 patients who underwent appendectomy over the past 18 years.
  • In the present report, we describe a rare case of primary signet ring cell carcinoma of the appendix with ovarian metastases and unresectable peritoneal dissemination occurring in a 67-year-old female patient.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Carcinoma, Signet Ring Cell / secondary. Ovarian Neoplasms / secondary. Peritoneal Neoplasms / secondary

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  • (PMID = 18837098.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2748216
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49. Yan TD, Brun EA, Sugarbaker PH: Discordant histology of primary appendiceal adenocarcinoid neoplasms with peritoneal dissemination. Ann Surg Oncol; 2008 May;15(5):1440-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Discordant histology of primary appendiceal adenocarcinoid neoplasms with peritoneal dissemination.
  • BACKGROUND: Adenocarcinoid is a rare appendiceal tumor that shows histologically both epithelial and neuroendocrine components.
  • We observed that some patients have peritoneal dissemination, which shows adenocarcinoma but lacks the neuroendocrine histology.
  • METHODS: Twenty-six patients with peritoneal dissemination from primary appendiceal adenocarcinoid tumors underwent cytoreductive surgery and perioperative intraperitoneal chemotherapy.
  • RESULTS: In nine of the 26 patients (35%) with a primary adenocarcinoid of the appendix, a loss of the neuroendocrine immunochemical marker was noted in peritoneal implants.
  • Discordant histology between the primary appendiceal adenocarcinoid and the peritoneal implants was statistically significantly associated with an improved survival (p = 0.0262), when patients were treated by cytoreductive surgery and perioperative intraperitoneal chemotherapy.
  • CONCLUSIONS: Discordant histology of the primary appendiceal tumor as compared to the peritoneal lesions occurs frequently in patients with adenocarcinoid.
  • [MeSH-major] Adenocarcinoma / secondary. Appendiceal Neoplasms / pathology. Carcinoid Tumor / secondary. Peritoneal Neoplasms / secondary

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  • (PMID = 18299936.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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50. Chen HT, Lee YT, Chou AS, Wu YK, Yin WY, Lee MC, Hsu YH: Primary appendiceal malignancy: a clinicopathologic study. Kaohsiung J Med Sci; 2006 Dec;22(12):618-25

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary appendiceal malignancy: a clinicopathologic study.
  • Primary appendiceal cancer is a rare neoplasm.
  • We analyzed the clinicopathologic characteristics and clinical outcomes of patients with primary appendiceal cancer treated at Buddhist Tzu Chi General Hospital in Eastern Taiwan.
  • We reviewed the medical records of patients who had appendectomy at our hospital over a 10-year period and studied those who had histologically proven malignant appendiceal neoplasms.
  • No patient was diagnosed correctly before surgery, and five (62.5%) had a preoperative diagnosis of acute appendicitis.
  • The important prognostic factors of primary appendiceal cancer included histologic subtypes and the extent of dissemination.
  • [MeSH-major] Appendiceal Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma, Mucinous / pathology. Aged. Cystadenocarcinoma, Mucinous / pathology. Female. Humans. Male. Middle Aged. Retrospective Studies. Tomography, X-Ray Computed

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  • (PMID = 17116623.001).
  • [ISSN] 1607-551X
  • [Journal-full-title] The Kaohsiung journal of medical sciences
  • [ISO-abbreviation] Kaohsiung J. Med. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China (Republic : 1949- )
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51. Pan Z, Repertinger S, Leonard R, Bewtra C, Gatalica Z, Sharma P: Cervical and endometrial metastases of appendiceal goblet cell carcinoid. Arch Pathol Lab Med; 2010 May;134(5):776-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cervical and endometrial metastases of appendiceal goblet cell carcinoid.
  • Appendiceal goblet cell carcinoid (GCC) is a rare tumor with histologic features of both adenocarcinoma and neuroendocrine tumor (carcinoid).
  • Clinically, it behaves more aggressively than classic appendiceal carcinoid and commonly presents with peritoneal carcinomatosis.
  • We report 2 cases of appendiceal GCC, one with uterine cervical involvement and the other with endometrial involvement as the initial presentations.
  • The second patient presented with abnormal uterine bleeding, and endometrial curettage showed an adenocarcinoma with signet ring cell features.
  • Primary appendiceal GCC was demonstrated in both cases after systematic clinical investigations.
  • Metastatic appendiceal GCC to uterine cervix and endometrium can potentially be misinterpreted as primary cervical or endometrial signet ring cell carcinoma.
  • Therefore, for any uterine cervical/endometrial signet ring cell carcinoma, a metastatic appendiceal GCC should be considered in the differential diagnosis, especially after excluding other primary sites.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Carcinoid Tumor / secondary. Endometrial Neoplasms / secondary. Uterine Cervical Neoplasms / secondary

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  • (PMID = 20441511.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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52. Mistry R, Ananthakrishnan K, Hamid BN, Powell C, Foster GE: Appendiceal carcinoma masquerading as recurrent urinary tract infections: case report and review of literature. Urology; 2006 Aug;68(2):428.e1-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Appendiceal carcinoma masquerading as recurrent urinary tract infections: case report and review of literature.
  • The investigations revealed an adenocarcinoma of the appendix fistulating into the bladder and causing irritative symptoms.
  • This unusual situation reminds us that the finding of bladder adenocarcinoma is rare, and it would be prudent to examine the lower gastrointestinal tract thoroughly to look for a bowel source, before recommending any ablative surgery.
  • [MeSH-major] Appendiceal Neoplasms / diagnosis. Urinary Tract Infections / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Recurrence

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  • (PMID = 16904475.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 14
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53. Gillion JF, Franco D, Chapuis O, Serpeau D, Convard JP, Jullès MC, Balaton A, Karkouche B, Capelle P, Parmentier T, Chollet JM, Thillois JM, Berthelot G: [Appendiceal mucoceles, pseudomyxoma peritonei and appendiceal mucinous neoplasms: update on the contribution of imaging to choice of surgical approach]. J Chir (Paris); 2009 Apr;146(2):150-66
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Appendiceal mucoceles, pseudomyxoma peritonei and appendiceal mucinous neoplasms: update on the contribution of imaging to choice of surgical approach].
  • [Transliterated title] Mucocèles appendiculaires, pseudomyxomes péritonéaux et tumeurs mucosécrétantes du carrefour iléocaecal: apport de l'imagerie dans la stratégie thérapeutique et le choix de la voie d'abord laparoscopique ou classique.
  • INTRODUCTION: The treatment of pseudomyxoma peritonei (PMPs) and appendiceal mucocele (AM) has changed radically.
  • Eleven patients had an intact AM, seven synchronous PMP (malignant appendiceal lesion in two of seven), six metachronous PMP (five with peritoneal mucinous carcinomatosis and one with diffuse peritoneal adenomucinosis) and three a ruptured AM but not PMP.
  • [MeSH-major] Adenocarcinoma, Mucinous / radiography. Appendiceal Neoplasms / radiography. Appendix / radiography. Mucocele / radiography. Peritoneal Neoplasms / radiography. Pseudomyxoma Peritonei / radiography

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  • [CommentIn] J Chir (Paris). 2009 Apr;146(2):167 [19540495.001]
  • (PMID = 19552906.001).
  • [ISSN] 0021-7697
  • [Journal-full-title] Journal de chirurgie
  • [ISO-abbreviation] J Chir (Paris)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Multicenter Study
  • [Publication-country] France
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54. Feltmate CM, Lee KR, Johnson M, Schorge JO, Wong KK, Hao K, Welch WR, Bell DA, Berkowitz RS, Mok SC: Whole-genome allelotyping identified distinct loss-of-heterozygosity patterns in mucinous ovarian and appendiceal carcinomas. Clin Cancer Res; 2005 Nov 1;11(21):7651-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Whole-genome allelotyping identified distinct loss-of-heterozygosity patterns in mucinous ovarian and appendiceal carcinomas.
  • PURPOSE: Mucinous adenocarcinoma of the ovary is one of the common histologic types of ovarian cancer.
  • In addition, the differential diagnosis of metastatic mucinous carcinomas to the ovaries, particularly those originating from the appendix, remains challenging.
  • The purpose of this study is to identify molecular biomarkers for mucinous ovarian adenocarcinoma and compare them with those of appendiceal origin.
  • EXPERIMENTAL DESIGN: Genome-wide loss-of-heterozygosity (LOH) analysis was done on DNA isolated from 28 microdissected primary mucinous ovarian carcinomas and five appendiceal adenocarcinomas.
  • Markers from high-loss regions were selected for further analysis on a total of 32 ovarian and 14 appendiceal cancers.
  • The frequency of allelic loss was similar between high-grade and low-grade mucinous ovarian carcinoma cases but was significantly higher in ovarian versus appendiceal cases.
  • In addition, LOH rates on five chromosomal loci were statistically different between ovarian and appendiceal carcinomas.
  • Despite histologic similarities between mucinous ovarian carcinomas and metastatic appendiceal carcinomas, they have distinct LOH profiles, which may be used for distinguishing the two diseases.
  • [MeSH-major] Adenocarcinoma, Mucinous / genetics. Appendiceal Neoplasms / genetics. Appendiceal Neoplasms / pathology. Carcinoma / genetics. Genome. Genotype. Heterozygote. Loss of Heterozygosity. Ovarian Neoplasms / genetics. Ovarian Neoplasms / pathology

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  • (PMID = 16278384.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P50CA165009; United States / NCRR NIH HHS / RR / RR33CA103595
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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55. Ahmed K, Hoque R, El-Tawil S, Khan MS, George ML: Adenocarcinoma of the appendix presenting as bilateral ureteric obstruction. World J Surg Oncol; 2008;6:23

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenocarcinoma of the appendix presenting as bilateral ureteric obstruction.
  • BACKGROUND: Adenocarcinoma of the vermiform appendix is a rare neoplasm of the gastrointestinal tract.
  • These presentations reflect various stages of a locally expanding tumour causing luminal obstruction of appendix.
  • CASE PRESENTATION: We report a case of appendicular adenocarcinoma found unexpectedly in a 43 year old male who presented with urinary symptoms.
  • Histopathology revealed well differentiated adenocarcinoma with signet ring morphology with multiple lymph node involvement.
  • Every attempt should be made to make a precise diagnosis through all the available means to direct the treatment along correct lines.
  • [MeSH-major] Adenocarcinoma / complications. Adenocarcinoma / diagnosis. Appendiceal Neoplasms / complications. Appendiceal Neoplasms / diagnosis. Ureteral Obstruction / etiology

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  • (PMID = 18291037.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2277416
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56. Bucher P, Gervaz P, Ris F, Oulhaci W, Egger JF, Morel P: Surgical treatment of appendiceal adenocarcinoid (goblet cell carcinoid). World J Surg; 2005 Nov;29(11):1436-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical treatment of appendiceal adenocarcinoid (goblet cell carcinoid).
  • Adenocarcinoid of the appendix is an infrequent tumor with histologic features of both adenocarcinoma and carcinoid tumor.
  • The aim of this study was to analyze long-term results of surgical treatment for appendiceal adenocarcinoid.
  • A retrospective review (1991-2003) identified seven patients (median age 72, range 27-81 years) treated for appendiceal adenocarcinoid.
  • Our results suggest that appendectomy alone could be used for appendiceal adenocarcinoid provided that the tumor (1) is less than 1 cm;.
  • (2) does not extend beyond the appendix adventitia;.
  • The risk for developing colorectal adenocarcinoma seems to be extremely high in patients treated for appendiceal adenocarcinoid and warrants close follow-up with colonoscopic screening.
  • [MeSH-major] Appendectomy. Appendiceal Neoplasms / surgery. Carcinoid Tumor / surgery

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  • (PMID = 16136284.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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57. Vidarsdottir H, Moller PH, Benediktsdottir KR, Geirsson G: Adenocarcinoma of the appendix with a fistula to the urinary bladder. Scand J Urol Nephrol; 2010 Nov;44(5):354-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenocarcinoma of the appendix with a fistula to the urinary bladder.
  • Adenocarcinoma of the vermiform appendix is a rare disease that constitutes less than 0.5% of all gastrointestinal malignancies.
  • She was diagnosed with adenocarcinoma of the appendix with a fistula to the urinary bladder.
  • [MeSH-major] Adenocarcinoma / complications. Appendiceal Neoplasms / complications. Urinary Fistula / etiology

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  • (PMID = 20509819.001).
  • [ISSN] 1651-2065
  • [Journal-full-title] Scandinavian journal of urology and nephrology
  • [ISO-abbreviation] Scand. J. Urol. Nephrol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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58. Sugarbaker PH: The natural history, gross pathology, and histopathology of appendiceal epithelial neoplasms. Eur J Surg Oncol; 2006 Aug;32(6):644-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The natural history, gross pathology, and histopathology of appendiceal epithelial neoplasms.
  • AIM: To report the pathology of appendiceal epithelial neoplasms a review of the Washington Cancer Institute experience and a PubMed literature search was performed.
  • FINDINGS: Epithelial appendiceal neoplasms present a significant oncologic challenge.
  • CONCLUSIONS: Appendiceal epithelial neoplasms should be regarded as a distinct clinical entity with special clinical treatments used for optimal management.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Adenoma / pathology. Appendiceal Neoplasms / pathology

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  • (PMID = 16621426.001).
  • [ISSN] 0748-7983
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 17
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59. Waku T: [A study on nine cases of mucocele of the appendix]. Nihon Shokakibyo Gakkai Zasshi; 2008 Feb;105(2):214-20

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A study on nine cases of mucocele of the appendix].
  • A clinicopathological study was made on 9 cases of mucocele (8 cases of adenoma and 1 case of adenocarcinoma) of the appendix treated at the hospital in the recent 12 years.
  • With abdominal CT, correct preoperative diagnosis was successfully made in 7 out of 9 cases of mucocele of the appendix.
  • Two cases of mucocele of the appendix were diagnosed as peritoneal pseudomyxoma before surgery.
  • The most common operative procedure was ileocecal resection in 4 cases including 2 cases undergone irrigation of the abdominal cavity, and partial cecectomy in 5 cases including 2 cases undergone irrigation in the abdominal cavity.
  • For a patient with adenocarcinoma, we repeated intraperitoneal chemotherapy with cisplatin after surgery.
  • Eight patients with adenoma are doing well, but one patient with adenocarcinoma died 48 months after surgery.
  • [MeSH-major] Appendix. Cecal Diseases / diagnosis. Mucocele / diagnosis
  • [MeSH-minor] Aged. Aged, 80 and over. Appendiceal Neoplasms / diagnosis. Appendiceal Neoplasms / surgery. Female. Humans. Male. Middle Aged

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  • (PMID = 18250592.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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60. Sayles M, Courtney E, Younis F, O'Donovan M, Ibrahim A, Fearnhead NS: Appendiceal mucinous adenocarcinoma presenting as an enterocutaneous fistula in an incisional hernia. BMJ Case Rep; 2010;2010
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Appendiceal mucinous adenocarcinoma presenting as an enterocutaneous fistula in an incisional hernia.
  • Following incision and drainage of the abscess, CT demonstrated an enterocutaneous fistula between the appendix and bone-graft incision with appendicitis assumed to be the original cause of the abscess.
  • At laparoscopy, the appendix was adherent to the hernia sac with mucinous material at the superficial orifice of the fistula site but not in the peritoneal cavity.
  • Histological evaluation confirmed a well-to-moderately differentiated mucinous adenocarcinoma arising on a background of dysplastic villous adenoma.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Appendiceal Neoplasms / diagnosis. Bone Transplantation. Hernia, Abdominal / diagnosis. Ilium / surgery. Intestinal Fistula / diagnosis. Postoperative Complications / diagnosis. Tissue and Organ Harvesting
  • [MeSH-minor] Abdominal Abscess / diagnosis. Aged. Appendectomy. Colectomy. Female. Humans. Laparoscopy. Lymph Node Excision. Neoplasm Staging. Reoperation

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  • (PMID = 22789695.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3038038
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61. Matsui H, Igarashi N, Okamura A, Itano O, Koyama Y, Miyakita M: Laparoscopy-assisted resection of an appendiceal mucinous cystadenoma. Tokai J Exp Clin Med; 2007 Dec;32(4):140-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Laparoscopy-assisted resection of an appendiceal mucinous cystadenoma.
  • We present a 48-year-old man with a complaint of dull right-lower abdominal pain who was diagnosed with mucocele of the appendix.
  • In the procedure, the entire right colon was freed from the retroperitoneal structures without rupturing the tumor; and ileocecal resection and anastomosis were performed extracorporeally.
  • The pathological diagnosis of the tumor was mucinous cystadenoma of the appendix, measuring 9.0 cm × 8.0 cm × 4.0 cm.
  • When resecting an appendiceal mucinous tumor laparoscopically, it is essential (1) to keep the tumor intact during manipulation, and to use a wound-protecting device when delivering the lesion;.
  • (2) to consider the extent of tumor resection with a negative surgical margin as well as prophylactic lymph node dissection in cases of suspected adenocarcinoma, even though the oncological adequacy of the laparoscopic procedure for carcinoma remains to be elucidated; and (3) to check whether any mucinous fluid has accumulated in the abdominal cavity, which represents an indication for open surgery.
  • [MeSH-major] Appendiceal Neoplasms / surgery. Cystadenoma, Mucinous / surgery. Laparoscopy / methods

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  • (PMID = 21318954.001).
  • [ISSN] 2185-2243
  • [Journal-full-title] The Tokai journal of experimental and clinical medicine
  • [ISO-abbreviation] Tokai J. Exp. Clin. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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62. Khan MN, Moran BJ: Four percent of patients undergoing colorectal cancer surgery may have synchronous appendiceal neoplasia. Dis Colon Rectum; 2007 Nov;50(11):1856-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Four percent of patients undergoing colorectal cancer surgery may have synchronous appendiceal neoplasia.
  • PURPOSE: An individual with colorectal cancer has a 3 percent risk of synchronous colonic neoplasia and further 2 to 3 percent risk of metachronous cancer, a risk that has prompted colonic surveillance.
  • The appendix has a similar mucosal pattern to the colon and it has been hypothesized that appendicular adenocarcinoma may account for 1 percent of all colorectal malignancies.
  • A special interest of the senior author in appendiceal and rectal cancer has prompted routine removal of the appendix in all cases undergoing surgery for colorectal cancer.
  • METHODS: Consecutive patients undergoing left colectomy or anterior resection for colorectal cancer had coincidental appendectomy with the specimen pathologically analyzed.
  • RESULTS: In total, 169 patients under the care of a single surgeon had colorectal cancer resection between April 2002 and April 2005: 63 patients had right hemicolectomy, 29 had left hemicolectomy, and 77 had rectal cancer resection.
  • CONCLUSIONS: Patients having colorectal cancer resection for adenocarcinoma should have appendicectomy performed.
  • Metachronous neoplasia is a risk in the retained appendix in patients with colorectal cancer.
  • Routine postoperative surveillance cannot assess the appendiceal mucosa, so there is little justification for not taking the opportunity to eliminate the possibility of future appendicitis or neoplasia.
  • [MeSH-major] Adenocarcinoma / epidemiology. Appendiceal Neoplasms / epidemiology. Colorectal Neoplasms / epidemiology. Neoplasms, Multiple Primary / epidemiology

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  • (PMID = 17763906.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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63. Rezkalla MA, Peterson KG, Ryan JJ: Pseudomyxoma peritonei: a case of mucinous adenocarcinoma of the appendix presenting as inguinal hernia. S D Med; 2006 Feb;59(2):54-5, 57
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  • [Title] Pseudomyxoma peritonei: a case of mucinous adenocarcinoma of the appendix presenting as inguinal hernia.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Appendiceal Neoplasms / diagnosis. Hernia, Inguinal / diagnosis. Peritoneal Neoplasms / diagnosis. Pseudomyxoma Peritonei / diagnosis

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  • (PMID = 16519367.001).
  • [ISSN] 0038-3317
  • [Journal-full-title] South Dakota medicine : the journal of the South Dakota State Medical Association
  • [ISO-abbreviation] S D Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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64. Benedix F, Reimer A, Gastinger I, Mroczkowski P, Lippert H, Kube R, Study Group Colon/Rectum Carcinoma Primary Tumor: Primary appendiceal carcinoma--epidemiology, surgery and survival: results of a German multi-center study. Eur J Surg Oncol; 2010 Aug;36(8):763-71

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary appendiceal carcinoma--epidemiology, surgery and survival: results of a German multi-center study.
  • BACKGROUND: While carcinoma of the colon is a common malignancy, primary carcinoma of the appendix is rare.
  • Many retrospective reviews outlined experience from different centers on appendiceal neoplasms.
  • The aim of this study was to analyze the type of surgery and survival of patients with appendiceal malignancies using data from a German multi-center observational study (31 341 patients).
  • METHODS: During a five-year period, 196 consecutive patients with malignant appendiceal tumors were distributed into four groups: appendiceal carcinoids, adenocarcinoma, mucinous adenocarcinoma and adenosquamous carcinoma.
  • RESULTS: Adenocarcinoma had the highest incidence (50.5%).
  • Metastatic spread at presentation was highest for adenosquamous and mucinous adenocarcinoma and each had a distinct pattern.
  • Among all appendiceal neoplasms, adenosquamous carcinoma is the rarest histological subtype which is most commonly associated with advanced tumor stage and worst prognosis.
  • [MeSH-major] Appendiceal Neoplasms / epidemiology. Appendiceal Neoplasms / surgery. Colectomy
  • [MeSH-minor] Adenocarcinoma / epidemiology. Adenocarcinoma / surgery. Adenocarcinoma, Mucinous / epidemiology. Adenocarcinoma, Mucinous / surgery. Adult. Aged. Appendicitis / diagnosis. Carcinoid Tumor / epidemiology. Carcinoid Tumor / surgery. Carcinoma, Adenosquamous / epidemiology. Carcinoma, Adenosquamous / surgery. Diagnosis, Differential. Female. Germany. Humans. Male. Middle Aged. Neoplasm Staging. Unnecessary Procedures / statistics & numerical data

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  • [Copyright] Copyright (c) 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20561765.001).
  • [ISSN] 1532-2157
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] England
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65. McQuellon RP, Russell GB, Shen P, Stewart JH 4th, Saunders W, Levine EA: Survival and health outcomes after cytoreductive surgery with intraperitoneal hyperthermic chemotherapy for disseminated peritoneal cancer of appendiceal origin. Ann Surg Oncol; 2008 Jan;15(1):125-33
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Survival and health outcomes after cytoreductive surgery with intraperitoneal hyperthermic chemotherapy for disseminated peritoneal cancer of appendiceal origin.
  • BACKGROUND: Cytoreductive surgery with intraperitoneal hyperthermic chemotherapy for peritoneal carcinomatosis of appendiceal origin can alleviate symptoms and prolong survival.
  • METHODS: Patients underwent cytoreductive surgery and intraperitoneal hyperthermic chemotherapy for peritoneal cancer.
  • Patients completed questionnaires consisting of demographic information and the Functional Assessment of Cancer Therapy, the SF-36 Medical Outcomes Study survey, the Center for Epidemiologic Studies-Depression Scale, and the ECOG Performance Status Rating before (T1) and after surgery at 3 (T2), 6 (T3), 12 (T4), and 24 (T5) months.
  • CONCLUSIONS: Although complications can affect short-term recovery, survival in appendix cancer patients with peritoneal cancer is good and for some can be achieved without major decrements in QOL at 1 year.
  • [MeSH-major] Adenocarcinoma / mortality. Appendiceal Neoplasms / mortality. Chemotherapy, Cancer, Regional Perfusion. Hyperthermia, Induced. Peritoneal Neoplasms / mortality

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  • (PMID = 18030535.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / K08 CA131482
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 50SG953SK6 / Mitomycin
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66. Zedníková I, Kuntscher V, Schmiedhuber P, Daum O: [Mucinous adenocarcinoma of the appendix--case report]. Rozhl Chir; 2010 Nov;89(11):682-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Mucinous adenocarcinoma of the appendix--case report].
  • [Transliterated title] Mucinózni adenokarcinom apendixu--kazuistika.
  • The authors are describing a case of a patient with the diagnosis of the appendicular cancer.
  • The 66-year-old patient underwent appendectomy because of signs of acute appendicitis, and than in the next step right-sided hemicolectomy because of histological finding of the mucinous adenocarcinoma of the appendix.
  • Mucinous adenocarcinoma is the most common type of appendicular cancer, none the less this diagnosis is very rare.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Appendiceal Neoplasms / diagnosis

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  • (PMID = 21409802.001).
  • [ISSN] 0035-9351
  • [Journal-full-title] Rozhledy v chirurgii : měsíčník Československé chirurgické společnosti
  • [ISO-abbreviation] Rozhl Chir
  • [Language] cze
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Czech Republic
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67. Dupre MP, Jadavji I, Matshes E, Urbanski SJ: Diverticular disease of the vermiform appendix: a diagnostic clue to underlying appendiceal neoplasm. Hum Pathol; 2008 Dec;39(12):1823-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diverticular disease of the vermiform appendix: a diagnostic clue to underlying appendiceal neoplasm.
  • Acquired diverticula of the vermiform appendix are rare and arise as a result of different pathogenetic mechanisms.
  • Although the association of appendiceal diverticulosis and neoplasia is known, it remains underemphasized in the teaching and practice of surgical pathology.
  • To investigate the frequency of appendiceal neoplasms with acquired diverticulosis, we conducted a retrospective analysis of all appendectomy specimens received in our institution for a 55-month period (January 2002-July 2006).
  • Eleven (48%) appendectomy specimens with diverticulosis also harbored an appendiceal neoplasm.
  • The association of appendiceal neoplasms with diverticulosis was statistically significant (P < .0001, 2-sided Fisher exact test).
  • We stress the need for meticulous gross assessment with histologic examination of the entire appendectomy specimen in cases of appendiceal diverticulosis.
  • As acquired diverticula represent a rare finding, examination of the entire appendix in this setting does not create a significant impact on the workload within the pathologic laboratory.
  • [MeSH-major] Adenocarcinoma / pathology. Appendiceal Neoplasms / pathology. Appendix / pathology. Carcinoid Tumor / pathology. Cystadenoma, Mucinous / pathology. Diverticulum / pathology

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  • (PMID = 18715614.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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68. Hristov AC, Young RH, Vang R, Yemelyanova AV, Seidman JD, Ronnett BM: Ovarian metastases of appendiceal tumors with goblet cell carcinoidlike and signet ring cell patterns: a report of 30 cases. Am J Surg Pathol; 2007 Oct;31(10):1502-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ovarian metastases of appendiceal tumors with goblet cell carcinoidlike and signet ring cell patterns: a report of 30 cases.
  • Synchronous and metachronous ovarian and appendiceal mucinous tumors are often the subject of diagnostic consultations in gynecologic pathology practices to address whether the tumors are independent neoplasms or related as primary and metastasis.
  • The ovarian and appendiceal tumors exhibited a variety of patterns of differentiation, including signet ring cell and glandular, with all displaying some goblet cell carcinoidlike patterns (nests, islands, cords, or cryptlike tubules with goblet cells); teratomatous elements were not identified in any ovarian tumors.
  • Chromogranin was expressed in 6 of 16 appendiceal tumors (mean/median: 11.9%/0%; range: 0% to 70%) and synaptophysin was expressed in 6 of 15 of these (mean/median: 16.7%/0%; range: 0% to 90%).
  • The clinicopathologic features of these ovarian tumors indicate they should be labeled as metastatic appendiceal adenocarcinomas rather than as goblet cell carcinoid tumors both to reflect their behavior and help distinguish them from the rare true primary ovarian goblet cell carcinoid tumors.
  • In cases in which the primary tumor is not already evident, their "goblet cell carcinoidlike" patterns should direct attention to the appendix as a possible source.
  • [MeSH-major] Adenocarcinoma / secondary. Appendiceal Neoplasms / pathology. Carcinoid Tumor / secondary. Carcinoma, Signet Ring Cell / secondary. Ovarian Neoplasms / secondary

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  • (PMID = 17895750.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chromogranins; 0 / Synaptophysin
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69. Stewart CJ, Tsukamoto T, Cooke B, Leung YC, Hammond IG: Ovarian mucinous tumour arising in mature cystic teratoma and associated with pseudomyxoma peritonei: report of two cases and comparison with ovarian involvement by low-grade appendiceal mucinous tumour. Pathology; 2006 Dec;38(6):534-8
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  • [Title] Ovarian mucinous tumour arising in mature cystic teratoma and associated with pseudomyxoma peritonei: report of two cases and comparison with ovarian involvement by low-grade appendiceal mucinous tumour.
  • AIMS: It is currently accepted that primary ovarian tumours rarely, if ever, give rise to mucinous ascites/pseudomyxoma peritonei (PMP) which most commonly results from the intra-abdominal spread of an appendiceal mucinous neoplasm.
  • However, primary ovarian mucinous tumours of appendiceal type arising within mature cystic teratomas appear to represent an exception to this rule.
  • In this report two further examples of this rare tumour are described, and the immunohistological phenotype including expression of MUC proteins is compared with secondary ovarian involvement by low-grade appendiceal mucinous neoplasm.
  • The results were compared with four cases of ovarian neoplasia secondary to primary appendiceal low-grade mucinous tumour.
  • RESULTS: The ovarian mucinous tumours associated with mature cystic teratomas were morphologically similar to those secondary to appendiceal neoplasia.
  • The immunophenotype of the teratoma-associated tumours and those secondary to appendiceal neoplasia was identical: there was strong and diffuse expression of CK20, CEA, CDX-2, MUC2 and MUC5AC with no reactivity for the other antisera tested.
  • The immunohistological findings in this study further support the view that such tumours exhibit a lower gastrointestinal and, more specifically, appendiceal phenotype.
  • [MeSH-major] Adenocarcinoma, Mucinous / secondary. Appendiceal Neoplasms / pathology. Ovarian Neoplasms / secondary. Peritoneal Neoplasms / pathology. Pseudomyxoma Peritonei / pathology. Teratoma / pathology

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  • (PMID = 17393980.001).
  • [ISSN] 0031-3025
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Homeodomain Proteins; 0 / MUC2 protein, human; 0 / MUC5AC protein, human; 0 / Mucin 5AC; 0 / Mucin-2; 0 / Mucins; 0 / Trans-Activators; 156560-97-3 / Cdx-2-3 protein
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70. Palanivelu C, Rangarajan M, John SJ, Senthilkumar K, Annapoorni S: Laparoscopic right hemicolectomy for mucocele due to a low-grade appendiceal mucinous neoplasm. JSLS; 2008 Apr-Jun;12(2):194-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Laparoscopic right hemicolectomy for mucocele due to a low-grade appendiceal mucinous neoplasm.
  • Tumors of the appendix are rare entities causing mucoceles.
  • Laparoscopic surgery for appendiceal tumors is still controversial, as inadvertent rupture of the lesion due to improper handling will cause pseudomyxoma peritonei.
  • The patient was incidentally discovered to have an appendiceal tumor and referred to us for laparoscopy.
  • Because the tumor involved the entire appendix, a laparoscopic right hemicolectomy was performed without directly handling the tumor.
  • Pathological diagnosis was low-grade appendiceal mucinous neoplasm.
  • The safety of laparoscopic appendectomy for the management of incidentally discovered appendiceal tumors has not yet been established.
  • A formal right hemicolectomy was performed because the tumor involved the entire appendix.
  • We now think laparoscopic surgery for appendiceal tumors is safe, feasible, and even may be beneficial.

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  • [Cites] Surg Laparosc Endosc Percutan Tech. 2002 Oct;12(5):367-70 [12409708.001]
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  • (PMID = 18435897.001).
  • [ISSN] 1086-8089
  • [Journal-full-title] JSLS : Journal of the Society of Laparoendoscopic Surgeons
  • [ISO-abbreviation] JSLS
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3016193
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71. You J, Xu L, Zheng GY, Qiu JF: [Diagnosis, treatment, and prognosis of primary appendiceal tumors: analysis of 37 cases]. Zhonghua Yi Xue Za Zhi; 2008 Jul 15;88(27):1909-11

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Diagnosis, treatment, and prognosis of primary appendiceal tumors: analysis of 37 cases].
  • OBJECTIVE: To investigate the pathology, diagnosis,treatment, and prognosis of primary appendiceal tumors.
  • METHODS: The clinical data of 37 patients with primary tumors of the appendix, 16 males and 21 females, aged 56 +/- 13 (35-87) hospitalized Jan.
  • All 37 cases received surgical operation with the diagnosis confirmed by pathology.
  • The pathological types included carcinoid tumor (n=12), mucinous tumor (n=17), and adenocarcinoma (n=8).
  • The 1, 3, and 5-year survival rates of the primary appendix carcinoid tumor, mucinous tumor, and adenocarcinoma were 100.0%, 100.0%, and 91.7%, 100.0%, 86.7%, and 71.5%, and 75.0%, 50.0%, and 50.0% respectively.
  • CONCLUSION: A rare disease, appendiceal tumors lack specific clinical features.
  • Intra-operative exploration and frozen section are very important for diagnosis and operation choice.
  • The prognosis of primary appendix carcinoid tumors is better.
  • [MeSH-major] Appendiceal Neoplasms / diagnosis. Appendiceal Neoplasms / surgery

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  • (PMID = 19040005.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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72. Yan TD, Links M, Xu ZY, Kam PC, Glenn D, Morris DL: Cytoreductive surgery and perioperative intraperitoneal chemotherapy for pseudomyxoma peritonei from appendiceal mucinous neoplasms. Br J Surg; 2006 Oct;93(10):1270-6
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  • [Title] Cytoreductive surgery and perioperative intraperitoneal chemotherapy for pseudomyxoma peritonei from appendiceal mucinous neoplasms.
  • The aim of this prospective study was to evaluate survival outcome and treatment-related prognostic markers in patients who underwent CRS and PIC for pseudomyxoma peritonei from appendiceal mucinous neoplasms.
  • [MeSH-major] Adenocarcinoma, Mucinous / mortality. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Appendiceal Neoplasms / mortality. Peritoneal Neoplasms / mortality. Pseudomyxoma Peritonei / mortality

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  • (PMID = 16838392.001).
  • [ISSN] 0007-1323
  • [Journal-full-title] The British journal of surgery
  • [ISO-abbreviation] Br J Surg
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 50SG953SK6 / Mitomycin; U3P01618RT / Fluorouracil
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73. Katsuno G, Kagawa S, Kokudo Y, Muraoka A, Tatemoto A, Sone Y, Tsumura M, Tsuruno M, Mizobuchi K: Ureteral metastasis from appendiceal cancer: report of a case. Surg Today; 2005;35(2):168-71

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  • [Title] Ureteral metastasis from appendiceal cancer: report of a case.
  • We report a case of primary appendiceal cancer that metastasized to the ureter.
  • After a detailed examination she was diagnosed to have cancer of the appendix, multiple liver metastases, and left hydronephrosis.
  • Since an obstruction of the ileocecum was obvious, she underwent an ileocecal resection and a resection of the spindle-shaped tumor invading the left ureter.
  • The spindle-shaped tumor was considered to be due to invasion of the appendiceal cancer to the left ureter.
  • [MeSH-major] Adenocarcinoma / pathology. Appendiceal Neoplasms / pathology. Ureteral Neoplasms / secondary

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  • (PMID = 15674503.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 15
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74. Pai RK, Beck AH, Norton JA, Longacre TA: Appendiceal mucinous neoplasms: clinicopathologic study of 116 cases with analysis of factors predicting recurrence. Am J Surg Pathol; 2009 Oct;33(10):1425-39
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Appendiceal mucinous neoplasms: clinicopathologic study of 116 cases with analysis of factors predicting recurrence.
  • The classification and nomenclature of appendiceal mucinous neoplasms are controversial.
  • To determine the outcome for patients with appendiceal mucinous neoplasms and further evaluate whether they can be stratified into groups that provide prognostic information, the clinicopathologic features of 116 patients (66 with clinical follow-up) with appendiceal mucinous neoplasms were studied.
  • From a wide variety of histopathologic features assessed, the important predictors that emerged on univariate statistical analysis were presence of extra-appendiceal neoplastic epithelium (P=0.01), high-grade cytology (P<0.0001), architectural complexity (P<0.001), and invasion (P<0.001).
  • All 16 patients with mucinous neoplasms confined to the appendix and lacking high-grade cytology, architectural complexity, and invasion were alive with no recurrences at median 59 months follow-up (=mucinous adenoma).
  • Twenty-seven patients with low-grade mucinous neoplasms with extra-appendiceal neoplastic epithelium had 1-year, 3-year, 5-year, and 10-year overall survival rates of 96%, 91%, 79%, and 46%, respectively, at median 53 months follow-up (=low-grade mucinous neoplasm with high risk of recurrence).
  • Three of the 4 patients with extra-appendiceal epithelium limited to the right lower quadrant developed full-blown peritoneal disease at 6, 41, and 99 months follow-up and 1 patient eventually died of disease.
  • Nine patients with appendiceal neoplasms with invasion or high-grade cytology and follow-up showed 1-year, 3-year, and 5-year overall survival rates of 86%, 57%, and 28% (=mucinous adenocarcinoma).
  • At 10 years, all patients with mucinous adenocarcinoma were either dead or lost to follow-up.
  • Appendiceal mucinous neoplasms can be stratified into 4 distinct risk groups on the basis of a careful histopathologic assessment of cytoarchitectural features and extent of disease at presentation.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Appendiceal Neoplasms / pathology. Neoplasm Recurrence, Local / epidemiology

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  • (PMID = 19641451.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Grant] United States / NLM NIH HHS / LM / T15 LM007033
  • [Publication-type] Journal Article
  • [Publication-country] United States
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75. Lohsiriwat V, Vongjirad A, Lohsiriwat D: Incidence of synchronous appendiceal neoplasm in patients with colorectal cancer and its clinical significance. World J Surg Oncol; 2009;7:51
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  • [Title] Incidence of synchronous appendiceal neoplasm in patients with colorectal cancer and its clinical significance.
  • BACKGROUND: The aims of this study were to evaluate the incidence of synchronous appendiceal neoplasm in patients with colorectal cancer, and to determine its clinical significance.
  • METHODS: Pathological reports and medical records were reviewed of patients with colorectal adenocarcinoma who underwent oncological resection of the tumor together with appendectomy at the Faculty of Medicine Siriraj Hospital, Mahidol University, Thailand between September 2000 and April 2008.
  • Of the patients studied, 228 (78 percent) had right hemicolectomy, whereas the others (22 percent) had surgery for left-sided colon cancer or rectal cancer.
  • One patient (0.3 percent) had epithelial appendiceal neoplasm (mucinous cystadenoma) and 3 patients (1.0 percent) had metastatic colorectal cancer in the mesoappendix.
  • However, the presence of synchronous appendiceal tumors and/or metastasis did not alter postoperative management, as these patients had received adjuvant therapy and were scheduled for surveillance program because of nodal involvement.
  • CONCLUSION: The incidence of synchronous primary appendiceal neoplasm and secondary (metastatic) appendiceal neoplasm in colorectal cancer patients was 0.3 and 1.0 percent, respectively.
  • [MeSH-major] Appendiceal Neoplasms / epidemiology. Colorectal Neoplasms / epidemiology. Neoplasms, Multiple Primary / epidemiology

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  • (PMID = 19490638.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2698838
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76. Bijelic L, Yan TD, Sugarbaker PH: Treatment failure following complete cytoreductive surgery and perioperative intraperitoneal chemotherapy for peritoneal dissemination from colorectal or appendiceal mucinous neoplasms. J Surg Oncol; 2008 Sep 15;98(4):295-9
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  • [Title] Treatment failure following complete cytoreductive surgery and perioperative intraperitoneal chemotherapy for peritoneal dissemination from colorectal or appendiceal mucinous neoplasms.
  • BACKGROUND: Peritonectomy combined with perioperative intraperitoneal chemotherapy is a successful treatment option for patients with peritoneal dissemination of appendiceal and colorectal malignancy.
  • METHODS: Patients with peritoneal dissemination from appendiceal or colorectal malignancy who underwent complete cytoreduction and perioperative intraperitoneal chemotherapy were included in this study.
  • RESULTS: Seventy patients with colorectal cancer carcinomatosis and 402 with appendiceal neoplasm were analyzed.
  • The median survival of 49 patients with colorectal cancer was 33 months while the median survival for patients with appendiceal neoplasms was not reached.
  • The most common type of recurrent disease was a localized intra-abdominal recurrence for both appendiceal and colon cancer patients.
  • This resulted in 5-year survival in 17% of colorectal patients and 70% of the appendiceal mucinous neoplasm patients.
  • [MeSH-major] Adenocarcinoma, Mucinous / therapy. Appendiceal Neoplasms / pathology. Chemotherapy, Cancer, Regional Perfusion / methods. Colorectal Neoplasms / pathology. Hyperthermia, Induced. Peritoneal Neoplasms / therapy

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  • (PMID = 18726900.001).
  • [ISSN] 1096-9098
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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77. Smeenk RM, van Velthuysen ML, Verwaal VJ, Zoetmulder FA: Appendiceal neoplasms and pseudomyxoma peritonei: a population based study. Eur J Surg Oncol; 2008 Feb;34(2):196-201
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  • [Title] Appendiceal neoplasms and pseudomyxoma peritonei: a population based study.
  • BACKGROUND: Pseudomyxoma peritonei (PMP) is a rare disease with an estimated incidence of 1 per million per year, and is thought to originate usually from an appendiceal mucinous epithelial neoplasm.
  • METHODS: The nationwide pathology database of the Netherlands (PALGA) was searched for the incidence of all appendectomies, the incidence of primary epithelial appendiceal lesions and the incidence and pathology history of patients with PMP.
  • An appendiceal lesion was found in 1482 appendiceal specimens (0.9%).
  • Coincidentally, an additional epithelial colonic neoplasm was found in 13% of patients with an appendiceal epithelial lesion.
  • A mucinous epithelial neoplasm was identified in 0.3% (73% benign, 27% malignant) of appendiceal specimens and 20% of these patients developed PMP.
  • The primary site was identified in 68% and dominated by the appendix (82%).
  • CONCLUSIONS: Primary epithelial lesions of the appendix are rare.
  • [MeSH-major] Adenocarcinoma, Mucinous / epidemiology. Appendiceal Neoplasms / epidemiology. Neoplasms, Multiple Primary / epidemiology. Peritoneal Neoplasms / epidemiology. Pseudomyxoma Peritonei / epidemiology

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  • (PMID = 17524597.001).
  • [ISSN] 1532-2157
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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78. Bruin SC, Verwaal VJ, Vincent A, van't Veer LJ, van Velthuysen ML: A clinicopathologic analysis of peritoneal metastases of colorectal and appendiceal origin. Ann Surg Oncol; 2010 Sep;17(9):2330-40
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  • [Title] A clinicopathologic analysis of peritoneal metastases of colorectal and appendiceal origin.
  • OBJECTIVE: To predict clinical outcome by classification of peritoneal metastases (PM) of colorectal or appendiceal origin.
  • BACKGROUND: This study investigates whether standardized histological classification can predict outcome for PM of colorectal or appendiceal origin treated with cytoreduction and hyperthermic intraperitoneal chemotherapy (HIPEC).
  • Of PM originating from an appendix tumor, 29% were of non-DPAM type.
  • [MeSH-major] Adenocarcinoma, Mucinous / secondary. Appendiceal Neoplasms / pathology. Colorectal Neoplasms / pathology. Peritoneal Neoplasms / secondary

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  • (PMID = 20232161.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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79. Lakatos PL, Gyori G, Halasz J, Fuszek P, Papp J, Jaray B, Lukovich P, Lakatos L: Mucocele of the appendix: an unusual cause of lower abdominal pain in a patient with ulcerative colitis. A case report and review of literature. World J Gastroenterol; 2005 Jan 21;11(3):457-9
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  • [Title] Mucocele of the appendix: an unusual cause of lower abdominal pain in a patient with ulcerative colitis. A case report and review of literature.
  • Colononoscopy and biopsy established the diagnosis of ulcerative colitis (proctosigmoiditis).
  • Cytology confirmed the diagnosis of mucocele.
  • He recovered well and the final histology revealed a cystadenoma of the appendix.
  • Although primary adenocarcinoma of the appendix is uncommon, the authors emphasize that preoperative diagnosis of an underlying malignancy in a mucocele is important for patient management; however, it is difficult on imaging studies.
  • [MeSH-major] Abdominal Pain / etiology. Appendiceal Neoplasms / complications. Appendix. Cecal Diseases / complications. Colitis, Ulcerative / complications. Cystadenoma / complications. Mucocele / complications
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged. Ultrasonography

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  • (PMID = 15637769.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 18
  • [Other-IDs] NLM/ PMC4205363
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80. Yoon SO, Kim BH, Lee HS, Kang GH, Kim WH, Kim YA, Kim JE, Chang MS: Differential protein immunoexpression profiles in appendiceal mucinous neoplasms: a special reference to classification and predictive factors. Mod Pathol; 2009 Aug;22(8):1102-12
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  • [Title] Differential protein immunoexpression profiles in appendiceal mucinous neoplasms: a special reference to classification and predictive factors.
  • Appendiceal mucinous neoplasms have been the focus of considerable debate in recent years.
  • We histologically classified 70 appendiceal mucinous neoplasms into three categories: 32 mucinous adenoma, 23 mucinous neoplasm of uncertain malignant potential, and 15 mucinous adenocarcinomas.
  • Our data showed that 9 out of the 24 proteins were more frequently altered in the mucinous adenocarcinoma group than in the mucinous adenoma group (P<0.05), including beta-catenin (13% in mucinous adenoma vs 60% in mucinous adenocarcinoma), CyclinD1 (44 vs 87%), Ki-67 (high labeling index: 31 vs 67%), NF-kappaB (19 vs 60%), VEGF (16 vs 87%), E-cadherin (0 vs 47%), p53 (6 vs 40%), MUC2 (9 vs 67%), and MUC5AC (3 vs 40%).
  • The distinct immunoexpression profile of mucinous neoplasm of uncertain malignant potential was placed between those of mucinous adenoma and mucinous adenocarcinoma (P<0.05).
  • Moreover, the mucinous adenoma, mucinous neoplasm of uncertain malignant potential, and mucinous adenocarcinoma categories displayed differences in terms of the number of altered markers among the nine proteins (P<0.05; mean 1.4 vs 2.6 vs 5.5, respectively).
  • In mucinous adenocarcinoma, the p53 status was related to disease-free survival and overall survival of patients (P<0.05, both).
  • In conclusion, protein immunoexpression profiles may facilitate the classification of appendiceal mucinous neoplasms.
  • In our study, the three tumor categories of mucinous adenoma, mucinous neoplasm of uncertain malignant potential, and mucinous adenocarcinoma exhibited distinct immunoexpression profiles.
  • Five and more altered protein markers, p53 overexpression, NF-kappaB positivity, and beta-catenin loss were predictive factors of adverse clinical outcomes in appendiceal mucinous adenocarcinomas.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Appendiceal Neoplasms / pathology. Biomarkers, Tumor / analysis. Cystadenoma, Mucinous / pathology


81. Subramanya D, Grivas PD, Styler M: Appendiceal carcinoma: a diagnostic and therapeutic challenge. Postgrad Med; 2008 Nov;120(4):95-100

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Appendiceal carcinoma: a diagnostic and therapeutic challenge.
  • Appendiceal carcinoma is a very rare clinical entity, constituting 1% of all colorectal malignancies and 1% of all appendectomy specimens.
  • Appendiceal malignancies often present atypically, thus creating diagnostic challenges.
  • We present a patient with mucinous carcinoma of the appendix who presented with hematuria and abdominal pain.
  • Similar case reports are extremely rare in the literature, while typical presentations of appendiceal carcinoma include abdominal pain, abdominal mass, early satiety, nausea, and iron-deficiency anemia.
  • Initially, the diagnostic investigation in our patient was focused on urinary tract disorders, but ultimately resulted in finding a mucinous appendiceal carcinoma.
  • An integrative approach is required in the diagnostic investigation and management of appendiceal malignancies.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Adenocarcinoma, Mucinous / surgery. Appendiceal Neoplasms / diagnosis. Appendiceal Neoplasms / surgery

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  • (PMID = 19020371.001).
  • [ISSN] 1941-9260
  • [Journal-full-title] Postgraduate medicine
  • [ISO-abbreviation] Postgrad Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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82. Esquivel J, Merriman B, Davis S, Manning D: Appendiceal cancer and peritoneal carcinomatosis: a report of 29 cases. Am Surg; 2006 Aug;72(8):714-7; discussion 717-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Appendiceal cancer and peritoneal carcinomatosis: a report of 29 cases.
  • Peritoneal surface malignancies of appendiceal origin arise from a perforated neoplasm with gradual expansion of the tumor within the abdomen.
  • [MeSH-major] Adenocarcinoma, Mucinous / secondary. Appendiceal Neoplasms / pathology. Peritoneal Neoplasms / secondary

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  • (PMID = 16913315.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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83. Schomas DA, Miller RC, Donohue JH, Gill S, Thurmes PJ, Haddock MG, Quevedo JF, Gunderson LL: Intraperitoneal treatment for peritoneal mucinous carcinomatosis of appendiceal origin after operative management: long-term follow-up of the Mayo Clinic experience. Ann Surg; 2009 Apr;249(4):588-95
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  • [Title] Intraperitoneal treatment for peritoneal mucinous carcinomatosis of appendiceal origin after operative management: long-term follow-up of the Mayo Clinic experience.
  • OBJECTIVE: To determine prognostic factors and the impact of intraperitoneal (IP) treatment after surgical resection of peritoneal mucinous carcinomatosis (PMC) of appendiceal origin.
  • Adverse prognostic factors for OS identified by univariate analysis included partial mucin debulking, adenocarcinoma histology, systemic chemotherapy, diffuse IP disease at presentation, and no IP therapy.
  • Adverse prognostic factors for OS included adenocarcinoma histology, systemic chemotherapy, and no IP therapy.
  • CONCLUSIONS: This large, single-institution, retrospective series with long-term follow-up suggests that IP chromic phosphate P 32 and 5-fluorouracil after maximal surgical resection of PMC of appendiceal origin is associated with improved OS and disease-free survival.
  • [MeSH-major] Adenocarcinoma, Mucinous / therapy. Appendiceal Neoplasms / therapy. Chemotherapy, Cancer, Regional Perfusion. Fluorouracil / administration & dosage. Peritoneal Neoplasms / therapy. Piperazines / administration & dosage
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Analysis of Variance. Appendectomy / methods. Cancer Care Facilities. Chemotherapy, Adjuvant. Cohort Studies. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Infusions, Parenteral. Kaplan-Meier Estimate. Male. Middle Aged. Minnesota. Multivariate Analysis. Neoplasm Staging. Probability. Proportional Hazards Models. Retrospective Studies. Risk Assessment. Statistics, Nonparametric. Survival Analysis. Time Factors

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  • (PMID = 19300231.001).
  • [ISSN] 1528-1140
  • [Journal-full-title] Annals of surgery
  • [ISO-abbreviation] Ann. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Piperazines; 59702-31-7 / 1-ethyl-2,3-dioxopiperazine; U3P01618RT / Fluorouracil
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84. Miyazaki K, Satoh H, Sekizawa K: Metastasis to appendix from lung adenocarcinoma. Int J Gastrointest Cancer; 2005;36(1):59-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastasis to appendix from lung adenocarcinoma.
  • We previously read with interest the case report by Filik et al. (International Journal of Gastrointestinal Cancer, 2003;34:55-58) on appendicular metastases from pancreatic adenocarcinoma.
  • His past medical history included a pneumonectomy of the left lung for locally advanced lung adenocarcinoma 9 mo previously.
  • TNM stage of the original lung cancer was T2N2M0.
  • Endoscopic evaluation revealed no obstruction, but failed to identify mucosal abnormalities in the ileocecal region.
  • He underwent a laparotomy, and tumor of the appendix, 3 x 3 cm in diameter, adhered to the surrounding tissue, but no perforation was seen.
  • The mass was excised in combination with an ileocecal resection, followed by ileocolic anastomosis.
  • Hisotologically, the neoplastic tumor cells infiltrated the submucosa, muscularis, and serosa, but mucosa of the appendix was intact, unremarkable, with no precursor lesion.
  • He was examined at regular periodic follow-ups, but died from lung cancer 12 mo after the resection of the metastatic tumor to the appendix.
  • [MeSH-major] Appendiceal Neoplasms / secondary. Lung Neoplasms / pathology

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  • [CommentOn] Int J Gastrointest Cancer. 2003;34(1):55-8 [15235136.001]
  • [Cites] Pathol Int. 1996 Mar;46(3):216-20 [10846573.001]
  • [Cites] Int J Gastrointest Cancer. 2003;34(1):55-8 [15235136.001]
  • [Cites] Dis Colon Rectum. 1970 Jul-Aug;13(4):336-40 [5459822.001]
  • (PMID = 16227637.001).
  • [ISSN] 1537-3649
  • [Journal-full-title] International journal of gastrointestinal cancer
  • [ISO-abbreviation] Int J Gastrointest Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Comment; Journal Article
  • [Publication-country] United States
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85. Chua TC, Pelz JO, Kerscher A, Morris DL, Esquivel J: Critical analysis of 33 patients with peritoneal carcinomatosis secondary to colorectal and appendiceal signet ring cell carcinoma. Ann Surg Oncol; 2009 Oct;16(10):2765-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Critical analysis of 33 patients with peritoneal carcinomatosis secondary to colorectal and appendiceal signet ring cell carcinoma.
  • BACKGROUND: Primary signet-ring cell carcinoma (SRC) of colorectal and appendiceal origin is a rare entity with an aggressive biology and clinical behavior.
  • METHODS: An observational study of 33 patients with SRC of colorectal or appendiceal origin was identified through a retrospective review of two peritoneal surface malignancy databases between January 1997 and December 2008.
  • RESULTS: Thirty-three patients (18 women (55%); mean age at diagnosis of carcinomatosis, 49 (standard deviation = 12) years) were identified to have SRC, with 15 cases of colorectal and 18 of appendiceal origin.
  • For patients with appendiceal SRC who underwent complete CRS and HIPEC versus systemic chemotherapy only, the median survival was 27 and 15 months (P = 0.12).
  • CONCLUSIONS: There seems to be less survival benefits after a complete CRS and HIPEC as a curative treatment for PC from colorectal SRC compared with that for non-SRC colorectal adenocarcinoma.
  • However, in patients with appendiceal SRC, long-term survival is a reality after treatment.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Carcinoma, Signet Ring Cell / secondary. Colorectal Neoplasms / pathology. Peritoneal Neoplasms / secondary

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  • (PMID = 19641972.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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86. Ratanarapee S, Nualyong C: Acute appendicitis as primary symptom of prostatic adenocarcinoma: report of a case. J Med Assoc Thai; 2010 Nov;93(11):1327-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Acute appendicitis as primary symptom of prostatic adenocarcinoma: report of a case.
  • The authors reported a 62-year-old Thai man who underwent appendectomy due to classical symptoms and signs of acute appendicitis and was subsequently referred to Siriraj Hospital for proper management after a pathological report of metastatic adenocarcinoma to the appendix.
  • [MeSH-major] Adenocarcinoma / secondary. Appendiceal Neoplasms / secondary. Appendicitis / diagnosis. Prostatic Neoplasms / pathology
  • [MeSH-minor] Appendectomy. Asian Continental Ancestry Group. Biopsy. Diagnosis, Differential. Humans. Male. Middle Aged. Neoplasm Metastasis. Orchiectomy. Prostate-Specific Antigen / blood. Treatment Outcome

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  • (PMID = 21114214.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Thailand
  • [Chemical-registry-number] EC 3.4.21.77 / Prostate-Specific Antigen
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87. Stewart JH 4th, Shen P, Russell GB, Bradley RF, Hundley JC, Loggie BL, Geisinger KR, Levine EA: Appendiceal neoplasms with peritoneal dissemination: outcomes after cytoreductive surgery and intraperitoneal hyperthermic chemotherapy. Ann Surg Oncol; 2006 May;13(5):624-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Appendiceal neoplasms with peritoneal dissemination: outcomes after cytoreductive surgery and intraperitoneal hyperthermic chemotherapy.
  • BACKGROUND: Appendiceal neoplasms frequently present with peritoneal dissemination (PD) and have a clinical course marked by bowel obstruction and subsequent death.
  • Few data have correlated outcome with appendiceal histology after cytoreductive surgery and intraperitoneal hyperthermic chemotherapy (IPHC).
  • We have reviewed our experience with cytoreductive surgery and IPHC for PD from the appendix.
  • METHODS: A total of 110 cases of PD from proven appendiceal neoplasms treated with IPHC were identified from a prospectively managed database.
  • RESULTS: A total of 116 IPHCs were performed on 110 patients for appendiceal PD between 1993 and 2004.
  • Age at presentation (P = .0134), performance status (P < .0001), time between diagnosis and IPHC (P = .0011), resection status (P = .0044), and length of hyperthermic chemoperfusion (P = .0193) were independently associated with survival.
  • CONCLUSIONS: The data show that long-term survival is anticipated in most patients who are treated with cytoreduction and IPHC for appendiceal PD.
  • In all, this work establishes a framework for the consideration of IPHC in future trials for appendiceal PD.
  • [MeSH-major] Adenocarcinoma, Mucinous / drug therapy. Adenocarcinoma, Mucinous / surgery. Appendiceal Neoplasms / pathology. Peritoneal Neoplasms / drug therapy. Peritoneal Neoplasms / surgery

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  • [CommentIn] Ann Surg Oncol. 2006 May;13(5):597-9 [16538404.001]
  • (PMID = 16538401.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / K08 CA131482
  • [Publication-type] Journal Article
  • [Publication-country] United States
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88. Sugarbaker PH, Bijelic L: The porta hepatis as a site of recurrence of mucinous appendiceal neoplasms treated by cytoreductive surgery and perioperative intraperitoneal chemotherapy. Tumori; 2008 Sep-Oct;94(5):694-700
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  • [Title] The porta hepatis as a site of recurrence of mucinous appendiceal neoplasms treated by cytoreductive surgery and perioperative intraperitoneal chemotherapy.
  • The goal of this study was to investigate the porta hepatis as a site of recurrence of appendiceal mucinous neoplasms.
  • METHODS: A prospective database on patients with peritoneal dissemination of mucinous appendiceal neoplasms has been maintained for 21 years.
  • RESULTS: In 710 patients treated for mucinous appendiceal cancer with a complete cytoreduction, 140 developed recurrent disease.
  • [MeSH-major] Adenocarcinoma, Mucinous / secondary. Adenocarcinoma, Mucinous / therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Appendectomy. Appendiceal Neoplasms / pathology. Appendiceal Neoplasms / therapy. Liver Neoplasms / secondary

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  • (PMID = 19112943.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Italy
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89. Gerritsen KG, Slee PH, Bollen TL, van Hecke W, Seldenrijk CA, Keijsers RG, Duurkens VA: Recurrent pneumonia due to an appendiceal mucinous cystadenocarcinoma: a rare presentation of a rare malignancy. Clin Med Oncol; 2009;3:9-12

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recurrent pneumonia due to an appendiceal mucinous cystadenocarcinoma: a rare presentation of a rare malignancy.
  • Mucinous cystadenocarcinoma of the appendix is a rare malignancy.
  • This is a report of a 74-year-old man who presented with recurrent pneumonia which turned out to be a postobstructive pneumonia complicating a large mucinous cystadenocarcinoma of the appendix with massive retroperitoneal and intrathoracic extension.
  • Mucinous cystadenocarcinoma of the appendix is a low-grade malignancy characterized by expansive growth due to progressive accumulation of mucinous fluid produced by the cancer cells.
  • The unusual retroperitoneal location of appendix in this patient probably allowed the tumor to expand massively in the retroperitoneal space and the thoracic cavity.
  • The value of (18)F-FDG PET in the diagnosis of mucinous cystadenocarcinoma of the appendix has not been determined yet, but it might be promising.
  • To the knowledge of the authors, this is the first report of an appendiceal mucinous cystadenocarcinoma with expansion into the thoracic cavity presenting with recurrent pneumonia.

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  • [Cites] J Gastrointest Surg. 2005 Jan;9(1):22-8; discussion 28-9 [15623441.001]
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  • (PMID = 20689604.001).
  • [ISSN] 1177-9314
  • [Journal-full-title] Clinical medicine. Oncology
  • [ISO-abbreviation] Clin Med Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] New Zealand
  • [Other-IDs] NLM/ PMC2872597
  • [Keywords] NOTNLM ; appendiceal neoplasms / mucinous adenocarcinoma / recurrent pneumonia / transdiaphragmatic lung invasion
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90. Sugarbaker PH, Alderman R, Edwards G, Marquardt CE, Gushchin V, Esquivel J, Chang D: Prospective morbidity and mortality assessment of cytoreductive surgery plus perioperative intraperitoneal chemotherapy to treat peritoneal dissemination of appendiceal mucinous malignancy. Ann Surg Oncol; 2006 May;13(5):635-44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prospective morbidity and mortality assessment of cytoreductive surgery plus perioperative intraperitoneal chemotherapy to treat peritoneal dissemination of appendiceal mucinous malignancy.
  • BACKGROUND: Appendiceal mucinous neoplasms present, in most patients, with peritoneal dissemination at the time of initial diagnosis.
  • Patients may have a borderline tumor showing disseminated peritoneal adenomucinosis or an aggressive malignancy identified as peritoneal mucinous adenocarcinoma.
  • Adverse events were tabulated for each cytoreduction performed in these appendiceal malignancy patients.
  • CONCLUSIONS: The mortality of 2.0% and the overall grade IV morbidity of 19% in these patients may be acceptable in light of modern standards for the management of gastrointestinal cancer.
  • [MeSH-major] Adenocarcinoma, Mucinous / drug therapy. Adenocarcinoma, Mucinous / surgery. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Appendiceal Neoplasms / pathology. Peritoneal Neoplasms / drug therapy. Peritoneal Neoplasms / surgery

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  • [CommentIn] Ann Surg Oncol. 2006 May;13(5):597-9 [16538404.001]
  • (PMID = 16523363.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 50SG953SK6 / Mitomycin; U3P01618RT / Fluorouracil
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91. Lin CY, Huang JS, Jwo SC, Chen HY: Recurrent gastric adenocarcinoma presenting as acute appendicitis: a case report. Int J Clin Pract Suppl; 2005 Apr;(147):89-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recurrent gastric adenocarcinoma presenting as acute appendicitis: a case report.
  • We report a case of acute appendicitis due to recurrent metastatic gastric adenocarcinoma involving only appendix, without the evidence of abdominal carcinomatosis 2 years after initial diagnosis of the primary gastric lesion.
  • [MeSH-major] Adenocarcinoma / secondary. Appendiceal Neoplasms / secondary. Appendicitis / etiology. Stomach Neoplasms / therapy

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  • (PMID = 15875636.001).
  • [ISSN] 1368-504X
  • [Journal-full-title] International journal of clinical practice. Supplement
  • [ISO-abbreviation] Int J Clin Pract Suppl
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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92. Lee YT, Wu HS, Hung MC, Lin ST, Hwang YS, Huang MH: Ruptured appendiceal cystadenoma presenting as right inguinal hernia in a patient with left colon cancer: a case report and review of literature. BMC Gastroenterol; 2006;6:32

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ruptured appendiceal cystadenoma presenting as right inguinal hernia in a patient with left colon cancer: a case report and review of literature.
  • BACKGROUND: Mucoceles resulting from cystadenomas of the appendix are uncommon.
  • There are several reports associating colonic malignancy with cystadenomas of the appendix.
  • Herein, we report an unusual and interesting case of right inguinal hernia associated with left colon cancer.
  • CASE PRESENTATION: A case of ruptured mucocele resulting from cystadenoma of the appendix was presented as right inguinal hernia in a 70-year-old male.
  • Localized pseudomyxoma peritonei associated with adenocarcinoma of the descending colon was diagnosed.
  • CONCLUSION: Synchronous colon cancer may occur in patients with appendiceal mucoceles.
  • [MeSH-major] Adenocarcinoma. Appendiceal Neoplasms / complications. Colonic Neoplasms. Cystadenoma / complications. Hernia, Inguinal / etiology. Mucocele / complications. Neoplasms, Second Primary

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  • (PMID = 17074081.001).
  • [ISSN] 1471-230X
  • [Journal-full-title] BMC gastroenterology
  • [ISO-abbreviation] BMC Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 27
  • [Other-IDs] NLM/ PMC1634861
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93. Yan TD, Bijelic L, Sugarbaker PH: Critical analysis of treatment failure after complete cytoreductive surgery and perioperative intraperitoneal chemotherapy for peritoneal dissemination from appendiceal mucinous neoplasms. Ann Surg Oncol; 2007 Aug;14(8):2289-99
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  • [Title] Critical analysis of treatment failure after complete cytoreductive surgery and perioperative intraperitoneal chemotherapy for peritoneal dissemination from appendiceal mucinous neoplasms.
  • The objective of this data analysis was to study treatment failure after complete cytoreduction for peritoneal dissemination from appendiceal mucinous neoplasms.
  • METHODS: Before June 2006, a total of 402 patients with peritoneal dissemination from appendiceal mucinous neoplasms underwent complete cytoreduction and PIC at the Washington Cancer Institute.
  • CONCLUSIONS: The present study reported the patterns of treatment failure after complete cytoreduction and demonstrated that a disease-free state is important for long-term survival in peritoneal dissemination from appendiceal mucinous neoplasms.
  • [MeSH-major] Adenocarcinoma, Mucinous / secondary. Appendiceal Neoplasms / surgery. Neoplasm Recurrence, Local. Peritoneal Neoplasms / pathology. Peritoneal Neoplasms / secondary

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  • [CommentIn] Ann Surg Oncol. 2007 Sep;14(9):2440-2 [17710499.001]
  • (PMID = 17541772.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Antimetabolites, Antineoplastic; 50SG953SK6 / Mitomycin; U3P01618RT / Fluorouracil
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94. Elias D, Glehen O, Pocard M, Quenet F, Goéré D, Arvieux C, Rat P, Gilly F, Association Française de Chirurgie: A comparative study of complete cytoreductive surgery plus intraperitoneal chemotherapy to treat peritoneal dissemination from colon, rectum, small bowel, and nonpseudomyxoma appendix. Ann Surg; 2010 May;251(5):896-901

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A comparative study of complete cytoreductive surgery plus intraperitoneal chemotherapy to treat peritoneal dissemination from colon, rectum, small bowel, and nonpseudomyxoma appendix.
  • OBJECTIVE: To report a large number of patients with peritoneal carcinomatosis (PC) treated with complete cytoreductive (CCR-0) plus intraperitoneal chemotherapy, and to compare the results according to the origin of the primary: colon, rectum, small bowel, and appendix (excluding peritoneal pseudomyxoma).
  • Primary sites were: colon (n=341), rectum (n=27), appendix (n=41), and small bowel (n=31).
  • The 5-year overall survival rates were not statistically different for the colon (29.7%), rectum (37.9%), nor the small bowel (33.8%), but was higher (P=0.01) for appendix adenocarcinoma (63.2%).
  • The multivariate analysis of prognostic factors singled out the extent of peritoneal seeding (P<0.0001), positive lymph nodes (P=0.001), and adjuvant systemic chemotherapy (P=0.002), whereas the origin of the tumor was borderline (P=0.06) in favor of appendix tumors.
  • Results were better for appendix adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / secondary. Appendiceal Neoplasms / pathology. Colonic Neoplasms / pathology. Intestinal Neoplasms / pathology. Peritoneal Neoplasms / secondary. Peritoneal Neoplasms / surgery. Rectal Neoplasms / pathology

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  • (PMID = 20395843.001).
  • [ISSN] 1528-1140
  • [Journal-full-title] Annals of surgery
  • [ISO-abbreviation] Ann. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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95. Lansdale N, Dagash H, Cohen M, Walker J: An ovarian tumour with a potential appendiceal origin. Pediatr Surg Int; 2008 Feb;24(2):245-7
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  • [Title] An ovarian tumour with a potential appendiceal origin.
  • The appendix was histologically normal.
  • It is known to occur simultaneously with tumours of the appendix.
  • Paediatric surgeons need to be aware of this rare tumour and when operating on any ovarian pathology should always inspect the peritoneal cavity for mucinous deposits and examine the appendix.
  • [MeSH-major] Adenocarcinoma, Mucinous / surgery. Appendiceal Neoplasms / surgery. Ovarian Neoplasms / surgery
  • [MeSH-minor] Adolescent. Appendectomy. Diagnosis, Differential. Female. Humans. Laparoscopy

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  • [Cites] Mod Pathol. 2005 Feb;18 Suppl 2:S33-50 [15761465.001]
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  • (PMID = 17401568.001).
  • [ISSN] 0179-0358
  • [Journal-full-title] Pediatric surgery international
  • [ISO-abbreviation] Pediatr. Surg. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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96. Farah-Klibi F, Kourda-Boujemaa J, Bouaskar I, Dziri C, Rachida Z, Jilani-Baltagi SB: Cystadenocarcinoma of the appendix: an incidental perioperatory finding in a patient with adenocarcinoma of the ascending and sigmoid colon: case report and review of literature. Pathologica; 2009 Dec;101(6):255-60

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cystadenocarcinoma of the appendix: an incidental perioperatory finding in a patient with adenocarcinoma of the ascending and sigmoid colon: case report and review of literature.
  • BACKGROUND: Primary adenocarcinomas of the appendix are uncommon, constituting 1% of all colorectal malignancies.
  • Appendiceal malignancies often present atypically, thus creating diagnostic challenges.
  • Although there are many pathology reports of primary cystadenocarcinoma of the appendix, only a limited number of cases have appeared in the radiological or surgical literature.
  • We present a unique case of primary cystadenocarcinoma of the appendix occurring concurrently with adenocarcinoma of the colon, and overview the clinical and therapeutic difficulties posed by this rare entity.
  • CASE PRESENTATION: A mucocele of the appendix, due to mucinous cystadenocarcinoma, was documented as an incidental perioperatory finding in a 68-year-old female.
  • Degenerated adenomatous polyp of the ascending colon and mucinous adenocarcinoma of the sigmoid colon invading the parietal peritoneum of the uterine and vagina was diagnosed.
  • At laparoscopy, a cystic appendiceal lesion was found, without perforation.
  • CONCLUSIONS: Preoperative diagnosis of an underlying malignancy in a mucocele is important for patient management, but is difficult to reach by imaging studies alone.
  • Synchronous colon cancer may occur in patients with appendiceal mucoceles.
  • [MeSH-major] Adenocarcinoma / pathology. Appendiceal Neoplasms / pathology. Colonic Neoplasms / pathology. Cystadenocarcinoma / pathology. Neoplasms, Multiple Primary / pathology

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  • (PMID = 20387715.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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97. O'Donnell ME, Badger SA, Beattie GC, Carson J, Garstin WI: Malignant neoplasms of the appendix. Int J Colorectal Dis; 2007 Oct;22(10):1239-48

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant neoplasms of the appendix.
  • BACKGROUND: Appendiceal neoplasms, first described in 1882, are still rare, with pre-operative diagnosis invariably difficult.
  • A literature search of the PubMed database was then performed using the medical search headings; appendix, tumour, neoplasm and malignancy.
  • Other appendiceal pathologies were identified after appendicectomies, hemicolectomy and oophorectomy.
  • Patients with classical carcinoid tumours (CCT) had better outcomes than patients with the goblet cell carcinoid, adenocarcinoma and lymphoma.
  • CONCLUSIONS: From our own experience and a subsequent review of the literature, we recommend right hemicolectomy as the treatment of choice for all malignant appendiceal neoplasms, except for small CCT less than 2 cm in diameter at the tip of the appendix, with a low proliferative index, without angiolymphatic or mesoappendiceal extension.
  • [MeSH-major] Appendiceal Neoplasms / diagnosis. Appendiceal Neoplasms / therapy

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  • (PMID = 17447078.001).
  • [ISSN] 0179-1958
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article; Meta-Analysis
  • [Publication-country] Germany
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98. Geisinger KR, Levine EA, Shen P, Bradley RF: Pleuropulmonary involvement in pseudomyxoma peritonei: morphologic assessment and literature review. Am J Clin Pathol; 2007 Jan;127(1):135-43
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We reviewed 101 patients uniformly treated at our institution for PP of appendiceal origin.
  • Of 5 patients, 3 had low-grade histologic features in the peritoneum; these showed variably proliferative, bland-appearing neoplastic cells arising from low-grade appendiceal mucinous neoplasms.
  • Pleural cytologic examination revealed high-grade adenocarcinoma cells singly, in small clusters, and in large spheres.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Lung Neoplasms / secondary. Peritoneal Neoplasms / pathology. Pleural Neoplasms / secondary. Pseudomyxoma Peritonei / pathology

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  • (PMID = 17145619.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 28
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99. Chetty R, Klimstra DS, Henson DE, Albores-Saavedra J: Combined classical carcinoid and goblet cell carcinoid tumor: a new morphologic variant of carcinoid tumor of the appendix. Am J Surg Pathol; 2010 Aug;34(8):1163-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Combined classical carcinoid and goblet cell carcinoid tumor: a new morphologic variant of carcinoid tumor of the appendix.
  • Carcinoid tumors are the most common neoplasms of the appendix.
  • In this report, we describe 5 cases of combined classical carcinoid and goblet cell carcinoid (GCC) tumors of the appendix.
  • The tumors (0.6 to 6.0 cm) were located in the mid-portion and the tip of the appendix.
  • All 5 appendiceal tumors had microscopic features of both classical carcinoid and GCC, either intimately admixed or separate but closely apposed.
  • The pelvic soft tissue and ovarian metastases in case 4 consisted predominantly of a signet ring cell carcinoma with a minor component of goblet cells and was interpreted as an adenocarcinoma ex-GCC.
  • In view of the fact that these combined carcinoid tumors appear to behave more as goblet cell carcinoids, detailed microscopic examination of classical carcinoid tumors of the appendix is suggested and larger series with longer follow-up is required to ascertain the true biologic potential of this unique form of combined carcinoid tumor of the appendix.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Carcinoid Tumor / pathology. Goblet Cells / pathology. Mixed Tumor, Malignant / pathology

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  • [CommentIn] Am J Surg Pathol. 2011 Aug;35(8):1248-50 [21753706.001]
  • (PMID = 20631606.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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100. Mateş IN, Iosif C, Bănceanu G, Ionescu M, Peltecu G, Dinu D, Constantin A, Hoară P, Mitru C, Constantinoiu S: [Features of Krukenberg-type tumors--clinical study and review]. Chirurgia (Bucur); 2008 Jan-Feb;103(1):23-38
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  • [Transliterated title] Particularităţi ale tumorilor de tip Krukenberg--studiu clinic şi review.
  • Krukenberg-type tumors (KT) are rare among ovarian metastases, but responsible for the most frequent diagnostic confusions with ovarian cancer.
  • They are peculiar: uncertain pathogenesis, challenging etiological diagnosis, poorer prognosis for the primary.
  • Timing of TK diagnosis: 3--metachronous, 4--synchronous, as incidental discovery and 2--retrospective pathological diagnosis.
  • Site of primary: 3--gastric, 5--colonic or appendiceal, 1--breast.
  • Microscopy: in 8 KT of digestive origin, 3--signet-ring cell carcinoma, 3--mucinous adenocarcinoma, 2--mixed pattern; 1 KT or breast origin was diagnosed by immunohistochemistry; 6/9 presented microscopic peritoneal despite a lack of strong correlation with the appearance of carcinomatosis or cytology of ascites.
  • Bilateral ovarian tumors, particularly in premenopausal women, must raise a high index of suspicion for KT, before or during surgery; diagnosis is a team challenge.
  • [MeSH-major] Appendiceal Neoplasms / secondary. Breast Neoplasms / secondary. Colonic Neoplasms / secondary. Krukenberg Tumor / secondary. Ovarian Neoplasms / pathology. Stomach Neoplasms / secondary
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Middle Aged. Prognosis. Treatment Outcome

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  • (PMID = 18459494.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] rum
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Romania
  • [Number-of-references] 86
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