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61. Ferreira CR, Carvalho JP, Soares FA, Siqueira SA, Carvalho FM: Mucinous ovarian tumors associated with pseudomyxoma peritonei of adenomucinosis type: immunohistochemical evidence that they are secondary tumors. Int J Gynecol Cancer; 2008 Jan-Feb;18(1):59-65
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Pseudomyxoma peritonei (PMP) is a clinical condition initially thought to be related to ovarian mucinous tumors; however, immunohistochemistry and molecular biology techniques have convincingly made the link to appendiceal mucinous neoplasms, resulting in changes in histologic and clinical approaches.
  • An appendiceal origin seems the most probable for this group of neoplasias.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Biomarkers, Tumor / metabolism. Intestinal Neoplasms / pathology. Neoplasms, Second Primary / pathology. Ovarian Neoplasms / pathology. Pseudomyxoma Peritonei / pathology


62. Bucher P, Gervaz P, Ris F, Oulhaci W, Inan I, Morel P: Laparoscopic versus open resection for appendix carcinoid. Surg Endosc; 2006 Jun;20(6):967-70
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  • [Title] Laparoscopic versus open resection for appendix carcinoid.
  • BACKGROUND: Since an increasing number of appendectomies are performed via laparoscopy, it is crucial to determine the impact of this approach on appendix carcinoid (AC) outcome.
  • Two patients died in the OP group, one due to metastatic carcinoid and the other due to metachronous colorectal cancer.
  • Risk for developing colorectal adenocarcinoma is high in AC patients and warrants follow-up of all patients with colonoscopic screening.
  • [MeSH-major] Appendectomy / methods. Appendiceal Neoplasms / surgery. Carcinoid Tumor / surgery. Laparoscopy

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  • (PMID = 16738993.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
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63. Sugarbaker PH, Bijelic L: The porta hepatis as a site of recurrence of mucinous appendiceal neoplasms treated by cytoreductive surgery and perioperative intraperitoneal chemotherapy. Tumori; 2008 Sep-Oct;94(5):694-700
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  • [Title] The porta hepatis as a site of recurrence of mucinous appendiceal neoplasms treated by cytoreductive surgery and perioperative intraperitoneal chemotherapy.
  • The goal of this study was to investigate the porta hepatis as a site of recurrence of appendiceal mucinous neoplasms.
  • METHODS: A prospective database on patients with peritoneal dissemination of mucinous appendiceal neoplasms has been maintained for 21 years.
  • RESULTS: In 710 patients treated for mucinous appendiceal cancer with a complete cytoreduction, 140 developed recurrent disease.
  • [MeSH-major] Adenocarcinoma, Mucinous / secondary. Adenocarcinoma, Mucinous / therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Appendectomy. Appendiceal Neoplasms / pathology. Appendiceal Neoplasms / therapy. Liver Neoplasms / secondary

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  • (PMID = 19112943.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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4. McQuellon RP, Russell GB, Shen P, Stewart JH 4th, Saunders W, Levine EA: Survival and health outcomes after cytoreductive surgery with intraperitoneal hyperthermic chemotherapy for disseminated peritoneal cancer of appendiceal origin. Ann Surg Oncol; 2008 Jan;15(1):125-33
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  • [Title] Survival and health outcomes after cytoreductive surgery with intraperitoneal hyperthermic chemotherapy for disseminated peritoneal cancer of appendiceal origin.
  • BACKGROUND: Cytoreductive surgery with intraperitoneal hyperthermic chemotherapy for peritoneal carcinomatosis of appendiceal origin can alleviate symptoms and prolong survival.
  • METHODS: Patients underwent cytoreductive surgery and intraperitoneal hyperthermic chemotherapy for peritoneal cancer.
  • Patients completed questionnaires consisting of demographic information and the Functional Assessment of Cancer Therapy, the SF-36 Medical Outcomes Study survey, the Center for Epidemiologic Studies-Depression Scale, and the ECOG Performance Status Rating before (T1) and after surgery at 3 (T2), 6 (T3), 12 (T4), and 24 (T5) months.
  • CONCLUSIONS: Although complications can affect short-term recovery, survival in appendix cancer patients with peritoneal cancer is good and for some can be achieved without major decrements in QOL at 1 year.
  • [MeSH-major] Adenocarcinoma / mortality. Appendiceal Neoplasms / mortality. Chemotherapy, Cancer, Regional Perfusion. Hyperthermia, Induced. Peritoneal Neoplasms / mortality

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  • (PMID = 18030535.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / K08 CA131482
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 50SG953SK6 / Mitomycin
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65. Hadj-Taieb I, Masmoudi A, Ayadi L, Meziou TJ, Khabir A, Charfeddine A, Boujelbène S, Beyrouti MI, Tahri N, Boudawara T, Turki H, Zahaf A: [Appendicular cystadenocarcinoma with cutaneous fistula]. Ann Dermatol Venereol; 2010 Mar;137(3):198-202
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Cutaneous metastasis of colorectal cancer is rare.
  • We report a case of fistular lesions of the buttocks revealing a mixed tumour of the appendix involving mucinous cystadenocarcinoma and carcinoid tumour.
  • Histological examination of skin biopsy specimens identified infiltration of the dermis by metastatic mucinous adenocarcinoma while colonoscopy showed a caecal tumour measuring 4 cm.
  • Histopathological examination of surgical specimen confirmed mixed tumour consisting of perforated mucinous cystadenocarcinoma and carcinoid tumour of the appendix.
  • DISCUSSION: Cutaneous metastasis of colorectal cancer is an uncommon event that usually occurs after identification of the primary tumour and generally indicates advanced-stage disease and an ominous prognosis.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Cecal Neoplasms / pathology. Cutaneous Fistula / etiology. Cystadenocarcinoma, Mucinous / pathology. Neoplasms, Multiple Primary / pathology

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  • [Copyright] Copyright 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20227562.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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66. Mall AS, Chirwa N, Govender D, Lotz Z, Tyler M, Rodrigues J, Kahn D, Goldberg P: MUC2, MUC5AC and MUC5B in the mucus of a patient with pseudomyxoma peritonei: biochemical and immunohistochemical study. Pathol Int; 2007 Aug;57(8):537-47
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  • Histopathological examination confirmed a mucinous appendicular adenocarcinoma.
  • [MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / secretion. Adenocarcinoma / surgery. Aged. Appendiceal Neoplasms / pathology. Appendiceal Neoplasms / secretion. Appendiceal Neoplasms / surgery. Biomarkers, Tumor / metabolism. Humans. Male. Mucin 5AC. Mucin-2. Mucin-5B. Palliative Care. Treatment Outcome

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  • (PMID = 17610480.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / MUC2 protein, human; 0 / MUC5AC protein, human; 0 / MUC5B protein, human; 0 / Mucin 5AC; 0 / Mucin-2; 0 / Mucin-5B; 0 / Mucins
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67. Cirocco WC: Right hemicolectomy remains the treatment of choice for adenocarcinoma of the appendix. Gastrointest Endosc; 2005 May;61(6):791; author reply 792
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  • [Title] Right hemicolectomy remains the treatment of choice for adenocarcinoma of the appendix.
  • [MeSH-major] Adenocarcinoma / surgery. Appendiceal Neoplasms / surgery. Colectomy / methods. Decision Making

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  • [CommentOn] Gastrointest Endosc. 2004 May;59(6):731-3 [15114326.001]
  • (PMID = 15856001.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Case Reports; Comment; Letter
  • [Publication-country] United States
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68. Feltmate CM, Lee KR, Johnson M, Schorge JO, Wong KK, Hao K, Welch WR, Bell DA, Berkowitz RS, Mok SC: Whole-genome allelotyping identified distinct loss-of-heterozygosity patterns in mucinous ovarian and appendiceal carcinomas. Clin Cancer Res; 2005 Nov 1;11(21):7651-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Whole-genome allelotyping identified distinct loss-of-heterozygosity patterns in mucinous ovarian and appendiceal carcinomas.
  • PURPOSE: Mucinous adenocarcinoma of the ovary is one of the common histologic types of ovarian cancer.
  • In addition, the differential diagnosis of metastatic mucinous carcinomas to the ovaries, particularly those originating from the appendix, remains challenging.
  • The purpose of this study is to identify molecular biomarkers for mucinous ovarian adenocarcinoma and compare them with those of appendiceal origin.
  • EXPERIMENTAL DESIGN: Genome-wide loss-of-heterozygosity (LOH) analysis was done on DNA isolated from 28 microdissected primary mucinous ovarian carcinomas and five appendiceal adenocarcinomas.
  • Markers from high-loss regions were selected for further analysis on a total of 32 ovarian and 14 appendiceal cancers.
  • The frequency of allelic loss was similar between high-grade and low-grade mucinous ovarian carcinoma cases but was significantly higher in ovarian versus appendiceal cases.
  • In addition, LOH rates on five chromosomal loci were statistically different between ovarian and appendiceal carcinomas.
  • Despite histologic similarities between mucinous ovarian carcinomas and metastatic appendiceal carcinomas, they have distinct LOH profiles, which may be used for distinguishing the two diseases.
  • [MeSH-major] Adenocarcinoma, Mucinous / genetics. Appendiceal Neoplasms / genetics. Appendiceal Neoplasms / pathology. Carcinoma / genetics. Genome. Genotype. Heterozygote. Loss of Heterozygosity. Ovarian Neoplasms / genetics. Ovarian Neoplasms / pathology

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  • (PMID = 16278384.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P50CA165009; United States / NCRR NIH HHS / RR / RR33CA103595
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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69. Schrofer C, Villiger P, Cathomas R: [Multiple primary neoplasms - coincidence or tumor syndrom?]. Praxis (Bern 1994); 2009 Sep 9;98(18):1027-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Multiple primary neoplasms occur either by hazard or in the context of hereditary cancer syndromes, after chronic toxic exposition, in immunodeficiency or as secondary malignancies after radio- and/or chemotherapy.
  • CASE REPORT: We present the history of an actually asymptomatic female patient with four different malignancies within 30 years: malignant melanoma (1976), liposarcoma (1983), carcinoma of the appendix (2006) and lymphoma (2006).
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Appendiceal Neoplasms / diagnosis. Ileal Neoplasms / diagnosis. Liposarcoma / diagnosis. Lymphoma, Follicular / diagnosis. Melanoma / diagnosis. Neoplasms, Second Primary / diagnosis. Skin Neoplasms / diagnosis. Soft Tissue Neoplasms / diagnosis

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  • (PMID = 19739050.001).
  • [ISSN] 1661-8157
  • [Journal-full-title] Praxis
  • [ISO-abbreviation] Praxis (Bern 1994)
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Switzerland
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70. Matsui H, Igarashi N, Okamura A, Itano O, Koyama Y, Miyakita M: Laparoscopy-assisted resection of an appendiceal mucinous cystadenoma. Tokai J Exp Clin Med; 2007 Dec;32(4):140-3
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  • [Title] Laparoscopy-assisted resection of an appendiceal mucinous cystadenoma.
  • We present a 48-year-old man with a complaint of dull right-lower abdominal pain who was diagnosed with mucocele of the appendix.
  • In the procedure, the entire right colon was freed from the retroperitoneal structures without rupturing the tumor; and ileocecal resection and anastomosis were performed extracorporeally.
  • The pathological diagnosis of the tumor was mucinous cystadenoma of the appendix, measuring 9.0 cm × 8.0 cm × 4.0 cm.
  • When resecting an appendiceal mucinous tumor laparoscopically, it is essential (1) to keep the tumor intact during manipulation, and to use a wound-protecting device when delivering the lesion;.
  • (2) to consider the extent of tumor resection with a negative surgical margin as well as prophylactic lymph node dissection in cases of suspected adenocarcinoma, even though the oncological adequacy of the laparoscopic procedure for carcinoma remains to be elucidated; and (3) to check whether any mucinous fluid has accumulated in the abdominal cavity, which represents an indication for open surgery.
  • [MeSH-major] Appendiceal Neoplasms / surgery. Cystadenoma, Mucinous / surgery. Laparoscopy / methods

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  • (PMID = 21318954.001).
  • [ISSN] 2185-2243
  • [Journal-full-title] The Tokai journal of experimental and clinical medicine
  • [ISO-abbreviation] Tokai J. Exp. Clin. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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71. Yantiss RK, Shia J, Klimstra DS, Hahn HP, Odze RD, Misdraji J: Prognostic significance of localized extra-appendiceal mucin deposition in appendiceal mucinous neoplasms. Am J Surg Pathol; 2009 Feb;33(2):248-55
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  • [Title] Prognostic significance of localized extra-appendiceal mucin deposition in appendiceal mucinous neoplasms.
  • Appendiceal mucinous neoplasms confined to the mucosa are benign, whereas those with disseminated peritoneal mucin deposits often follow an indolent, but malignant, course.
  • Not infrequently, appendiceal mucinous neoplasms are associated with localized periappendiceal mucin deposits, but lack diffuse peritoneal involvement.
  • Although some investigators consider both acellular and cellular periappendiceal mucin to pose no, or minimal, risk for recurrent disease, the biologic importance of localized extra-appendiceal mucin has never been evaluated.
  • We identified 65 patients with appendiceal mucinous neoplasms, all of whom had localized periappendiceal mucin deposits without diffuse peritoneal involvement, and assessed them for the presence of extra-appendiceal epithelium and clinical outcome.
  • Most (77%) cases showed acellular periappendiceal mucin, but 15 (23%) had scant extra-appendiceal epithelium (range: 1 to 12 cell clusters).
  • Thus, patients with appendiceal mucinous neoplasms and acellular periappendiceal mucin are unlikely to develop recurrent disease.
  • However, microscopic examination of the entire appendix is necessary, as lesions with extra-appendiceal tumor cells are more likely to progress to disseminated disease and result in death of the patient, even if the mucin is paucicellular and confined to the periappendiceal region.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Appendiceal Neoplasms / pathology. Mucins / metabolism

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  • (PMID = 18852679.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Mucins
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72. Tran TA, Holloway RW, Finkler NJ: Metastatic appendiceal mucinous adenocarcinoma to well-differentiated diffuse mesothelioma of the peritoneal cavity: a mimicker of florid mesothelial hyperplasia in association with neoplasms. Int J Gynecol Pathol; 2008 Oct;27(4):526-30
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  • [Title] Metastatic appendiceal mucinous adenocarcinoma to well-differentiated diffuse mesothelioma of the peritoneal cavity: a mimicker of florid mesothelial hyperplasia in association with neoplasms.
  • The subsequent operation, however, demonstrated a mucinous neoplasm of the appendix with involvement of the peritoneal cavity in the form of peritoneal mucinous carcinomatosis as well as metastases to the uterine serosa and adnexal surfaces.
  • Microscopic analysis revealed an appendiceal adenocarcinoma with signet-ring-cell features that has metastasized to a diffuse well-differentiated mesothelioma of the peritoneal cavity.
  • To the best of our knowledge, this is the first report of a metastatic appendiceal mucinous adenocarcinoma to a well-differentiated diffuse mesothelioma of the peritoneal cavity.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Appendiceal Neoplasms / pathology. Mesothelioma / pathology. Peritoneal Neoplasms / secondary
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Histocytochemistry. Humans

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  • (PMID = 18753969.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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73. Sugarbaker PH, Alderman R, Edwards G, Marquardt CE, Gushchin V, Esquivel J, Chang D: Prospective morbidity and mortality assessment of cytoreductive surgery plus perioperative intraperitoneal chemotherapy to treat peritoneal dissemination of appendiceal mucinous malignancy. Ann Surg Oncol; 2006 May;13(5):635-44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prospective morbidity and mortality assessment of cytoreductive surgery plus perioperative intraperitoneal chemotherapy to treat peritoneal dissemination of appendiceal mucinous malignancy.
  • BACKGROUND: Appendiceal mucinous neoplasms present, in most patients, with peritoneal dissemination at the time of initial diagnosis.
  • Patients may have a borderline tumor showing disseminated peritoneal adenomucinosis or an aggressive malignancy identified as peritoneal mucinous adenocarcinoma.
  • Adverse events were tabulated for each cytoreduction performed in these appendiceal malignancy patients.
  • CONCLUSIONS: The mortality of 2.0% and the overall grade IV morbidity of 19% in these patients may be acceptable in light of modern standards for the management of gastrointestinal cancer.
  • [MeSH-major] Adenocarcinoma, Mucinous / drug therapy. Adenocarcinoma, Mucinous / surgery. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Appendiceal Neoplasms / pathology. Peritoneal Neoplasms / drug therapy. Peritoneal Neoplasms / surgery

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  • [CommentIn] Ann Surg Oncol. 2006 May;13(5):597-9 [16538404.001]
  • (PMID = 16523363.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 50SG953SK6 / Mitomycin; U3P01618RT / Fluorouracil
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74. Kane JM 3rd: The "alphabet soup" of peritoneal dissemination from appendiceal neoplasms and other malignancies. Ann Surg Oncol; 2006 May;13(5):597-9
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  • [Title] The "alphabet soup" of peritoneal dissemination from appendiceal neoplasms and other malignancies.
  • [MeSH-major] Adenocarcinoma, Mucinous / secondary. Appendiceal Neoplasms / pathology. Peritoneal Neoplasms / secondary

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  • [CommentOn] Ann Surg Oncol. 2006 May;13(5):624-34 [16538401.001]
  • [CommentOn] Ann Surg Oncol. 2006 May;13(5):635-44 [16523363.001]
  • (PMID = 16538404.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Comment; Editorial
  • [Publication-country] United States
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75. Rankovic VI, Masirevic VP, Pavlov MJ, Ceranic MS, Milenkovic MG, Simic AP, Kecmanovic DM: Hemodynamic and cardiovascular problems during modified hyperthermic intraperitoneal perioperative chemotherapy. Hepatogastroenterology; 2007 Mar;54(74):364-6
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  • BACKGROUND/AIMS: Cytoreductive surgery and hyperthermic intraperitoneal perioperative chemotherapy (HIPEC) significantly improves patients survival with peritoneal carcinomatosis especially in low-grade tumor e.g. ovarian and appendiceal adenocarcinoma, peritoneal pseudomyxoma and grade I gastric and colorectal cancer.
  • [MeSH-major] Antineoplastic Agents / administration & dosage. Blood Pressure / physiology. Cardiac Output / physiology. Chemotherapy, Cancer, Regional Perfusion / adverse effects. Colorectal Neoplasms / drug therapy. Colorectal Neoplasms / surgery. Heart Rate / physiology. Hyperthermia, Induced / adverse effects. Ovarian Neoplasms / drug therapy. Ovarian Neoplasms / surgery. Peritoneal Neoplasms / drug therapy. Peritoneal Neoplasms / surgery. Postoperative Complications / physiopathology. Pseudomyxoma Peritonei / drug therapy. Pseudomyxoma Peritonei / surgery

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  • (PMID = 17523275.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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76. Roy P, Chetty R: Goblet cell carcinoid tumors of the appendix: An overview. World J Gastrointest Oncol; 2010 Jun 15;2(6):251-8
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  • [Title] Goblet cell carcinoid tumors of the appendix: An overview.
  • Goblet cell carcinoid is an enigmatic and rare tumor involving the appendix almost exclusively.
  • These may be of signet ring cell type or poorly differentiated adenocarcinoma.
  • Recently molecular studies have shown these tumors to lack the signatures of adenocarcinoma but they have some changes similar to that of ileal carcinoids (allelic loss of chromosome 11q, 16q and 18q).
  • The natural history of GCC is intermediate between carcinoids and adenocarcinomas of the appendix.

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  • (PMID = 21160637.001).
  • [ISSN] 1948-5204
  • [Journal-full-title] World journal of gastrointestinal oncology
  • [ISO-abbreviation] World J Gastrointest Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2998842
  • [Keywords] NOTNLM ; Appendiceal neoplasm / Goblet cell carcinoid / Mucin-producing neuroendocrine tumor of appendix
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77. Chetty R, Klimstra DS, Henson DE, Albores-Saavedra J: Combined classical carcinoid and goblet cell carcinoid tumor: a new morphologic variant of carcinoid tumor of the appendix. Am J Surg Pathol; 2010 Aug;34(8):1163-7
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  • [Title] Combined classical carcinoid and goblet cell carcinoid tumor: a new morphologic variant of carcinoid tumor of the appendix.
  • Carcinoid tumors are the most common neoplasms of the appendix.
  • In this report, we describe 5 cases of combined classical carcinoid and goblet cell carcinoid (GCC) tumors of the appendix.
  • The tumors (0.6 to 6.0 cm) were located in the mid-portion and the tip of the appendix.
  • All 5 appendiceal tumors had microscopic features of both classical carcinoid and GCC, either intimately admixed or separate but closely apposed.
  • The pelvic soft tissue and ovarian metastases in case 4 consisted predominantly of a signet ring cell carcinoma with a minor component of goblet cells and was interpreted as an adenocarcinoma ex-GCC.
  • In view of the fact that these combined carcinoid tumors appear to behave more as goblet cell carcinoids, detailed microscopic examination of classical carcinoid tumors of the appendix is suggested and larger series with longer follow-up is required to ascertain the true biologic potential of this unique form of combined carcinoid tumor of the appendix.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Carcinoid Tumor / pathology. Goblet Cells / pathology. Mixed Tumor, Malignant / pathology

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  • [CommentIn] Am J Surg Pathol. 2011 Aug;35(8):1248-50 [21753706.001]
  • (PMID = 20631606.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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78. Umemoto M, Shiota M, Shimaoka M, Hoshiai H: Definitive diagnosis of primary adenocarcinoma of the appendix by laparoscopic appendectomy. J Obstet Gynaecol Res; 2007 Aug;33(4):590-4
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  • [Title] Definitive diagnosis of primary adenocarcinoma of the appendix by laparoscopic appendectomy.
  • We report a 62-year-old woman with a primary adenocarcinoma of the appendix mimicking ovarian tumor.
  • However, the present case suggests that, in some cases, if cancer of the appendix can be diagnosed early, laparotomy can be avoided and the cancer treated with minimally invasive laparoscopic surgery alone.
  • [MeSH-major] Adenocarcinoma / pathology. Appendiceal Neoplasms / pathology

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  • (PMID = 17688638.001).
  • [ISSN] 1341-8076
  • [Journal-full-title] The journal of obstetrics and gynaecology research
  • [ISO-abbreviation] J. Obstet. Gynaecol. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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79. Bibi R, Pranesh N, Saunders MP, Wilson MS, O'dwyer ST, Stern PL, Renehan AG: A specific cadherin phenotype may characterise the disseminating yet non-metastatic behaviour of pseudomyxoma peritonei. Br J Cancer; 2006 Nov 6;95(9):1258-64
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  • Pseudomyxoma peritonei (PMP) is a rare neoplasm of mainly appendiceal origin, characterised by excess intra-abdominal mucin production leading to high morbidity and mortality.
  • This study determined the expression of several markers of colorectal differentiation (carcinoembryonic antigen (CEA), cytokeratins (CK20 and CK7), epithelial membrane antigen), mucin production (MUC-2, interleukin-9 (IL-9), IL-9 receptor (IL-9Ralpha)), and cell adhesion (N- and E-cadherin, vimentin) in PMP tissue (n=26) compared with expressions in normal colonic mucosa (n=19) and colorectal adenocarcinoma (n=26).
  • Similarly, expressions of mucin-related proteins were comparable for adenocarcinoma and PMP, with the exception that IL-9 expression was uncommon in adenocarcinoma (P=0.009).
  • These early characterisation studies demonstrate similarities between PMP and colorectal adenocarcinoma, but also reveal a specific cadherin phenotype that may characterise the distinct non-metastasising behaviour of PMP, and form the basis for future mechanistic and therapy-targeting research.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoembryonic Antigen / analysis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Interleukin-9 / analysis. Keratin-20 / analysis. Keratin-7 / analysis. Male. Middle Aged. Mucin-1 / analysis. Mucin-2. Mucins / analysis. Neoplasm Metastasis. Receptors, Interleukin-9 / analysis. Tumor Cells, Cultured. Vimentin / analysis

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  • (PMID = 17031402.001).
  • [ISSN] 0007-0920
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cadherins; 0 / Carcinoembryonic Antigen; 0 / Interleukin-9; 0 / Keratin-20; 0 / Keratin-7; 0 / MUC2 protein, human; 0 / Mucin-1; 0 / Mucin-2; 0 / Mucins; 0 / Receptors, Interleukin-9; 0 / Vimentin
  • [Other-IDs] NLM/ PMC2360585
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80. Sieren LM, Collins JN, Weireter LJ, Britt RC, Reed SF, Novosel TJ, Britt LD: The incidence of benign and malignant neoplasia presenting as acute appendicitis. Am Surg; 2010 Aug;76(8):808-11
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  • It is most often secondary to lymphoid hyperplasia, however it can also result from obstruction of the appendiceal lumen by a mass.
  • We retrospectively reviewed all patients admitted with the diagnosis of appendicitis to our Acute Care Surgery Service from July 1, 2007 to June 30, 2009.
  • Final pathology revealed four colonic adenocarcinoma; three mucinous tumors; one carcinoid; one endometrioma; and one patient had a combination of a mucinous cystadenoma, a carcinoid tumor, and endometriosis of the appendix.
  • Colonic and appendiceal neoplasia are not unusual etiologies of appendicitis.
  • [MeSH-major] Appendicitis / diagnosis. Neoplasms / diagnosis
  • [MeSH-minor] Acute Disease. Adult. Age Factors. Aged. Appendiceal Neoplasms / diagnosis. Diagnosis, Differential. Digestive System Neoplasms / diagnosis. Female. Humans. Male. Middle Aged. Retrospective Studies. Tomography, X-Ray Computed

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  • (PMID = 20726408.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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81. Nishio R, Furuya Y, Akashi T, Okumura A, Fuse H: Primary adenocarcinoma of the appendix invading the urinary bladder. Int Urol Nephrol; 2006;38(3-4):481-2
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  • [Title] Primary adenocarcinoma of the appendix invading the urinary bladder.
  • We report a case of adenocarcinoma of the appendix invading the urinary bladder in a 75-year-old man.
  • At operation a primary neoplasm of the appendix invading the bladder was discovered and en bloc resection of the urinary bladder with the adherent cecum followed by an ileocolonic anastomosis and ureterocutaneostomy was performed.
  • [MeSH-major] Adenocarcinoma / pathology. Appendiceal Neoplasms / pathology. Urinary Bladder Neoplasms / pathology

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  • (PMID = 17160444.001).
  • [ISSN] 0301-1623
  • [Journal-full-title] International urology and nephrology
  • [ISO-abbreviation] Int Urol Nephrol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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82. Ko YH, Jung CK, Oh SN, Kim TH, Won HS, Kang JH, Kim HJ, Kang WK, Oh ST, Hong YS: Primary signet ring cell carcinoma of the appendix: a rare case report and our 18-year experience. World J Gastroenterol; 2008 Oct 7;14(37):5763-8
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  • [Title] Primary signet ring cell carcinoma of the appendix: a rare case report and our 18-year experience.
  • Primary adenocarcinoma of the appendix is a rare malignancy that constitutes < 0.5% of all gastrointestinal neoplasms.
  • Moreover, primary signet ring cell carcinoma of the appendix is an exceedingly rare entity.
  • We have encountered 15 cases of primary appendiceal cancer among 3389 patients who underwent appendectomy over the past 18 years.
  • In the present report, we describe a rare case of primary signet ring cell carcinoma of the appendix with ovarian metastases and unresectable peritoneal dissemination occurring in a 67-year-old female patient.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Carcinoma, Signet Ring Cell / secondary. Ovarian Neoplasms / secondary. Peritoneal Neoplasms / secondary


83. Maheshwari V, Tsung A, Lin Y, Zeh HJ 3rd, Finkelstein SD, Bartlett DL: Analysis of loss of heterozygosity for tumor-suppressor genes can accurately classify and predict the clinical behavior of mucinous tumors arising from the appendix. Ann Surg Oncol; 2006 Dec;13(12):1610-6
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  • [Title] Analysis of loss of heterozygosity for tumor-suppressor genes can accurately classify and predict the clinical behavior of mucinous tumors arising from the appendix.
  • METHODS: Tissue specimens from 23 mucinous appendiceal tumors were analyzed.
  • [MeSH-major] Adenocarcinoma, Mucinous / genetics. Appendiceal Neoplasms / genetics. Genes, Tumor Suppressor. Loss of Heterozygosity / genetics. Pseudomyxoma Peritonei / genetics

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  • (PMID = 17009159.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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84. Nair RL, Tobias J, Stemmerman G, Lowy AM: Cerebral edema in a patient following cytoreductive surgery and hyperthermic intraoperative intraperitoneal chemoperfusion. World J Surg Oncol; 2006;4:85
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  • We describe a fatal case of cerebral edema in a patient with appendiceal carcinoma and an underlying seizure disorder who underwent cytoreductive surgery and HIPEC.
  • CASE PRESENTATION: A case of fatal postoperative cerebral edema is presented in a patient with an underlying seizure disorder and recurrent mucinous adenocarcinoma of the appendix.

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  • (PMID = 17137499.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1697813
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85. Xiao SY: Mucinous Neoplasms of the Vermiform Appendix. Surg Pathol Clin; 2010 Jun;3(2):395-409
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  • [Title] Mucinous Neoplasms of the Vermiform Appendix.
  • Most epithelial neoplasms of the vermiform appendix are of mucinous type and can be stratified into 3 main diagnostic categories:.
  • (1) adenoma, (2) mucinous neoplasms of uncertain malignant potential or low-grade mucinous neoplasm, and (3) adenocarcinoma.
  • Clinically, appendiceal mucinous adenomas and adenocarcinomas may present as right lower abdominal pain mimicking acute appendicitis, a mass, or pseudomyxoma peritonei.
  • Nomenclature currently in use to describe and diagnose mucinous tumors of the appendix, particularly those of low morphologic grade, varies among surgical pathologists and centers, resulting in different histologic and clinical features being attributed to these entities in the literature.
  • It may be of help, as already attempted by some investigators, to simply apply algorithmic parameters for such lesions (grade of the primary lesion, extensiveness and composite of extra-appendiceal involvement, and so forth), instead of adopting rigid classification categories.
  • This approach allows for more objective data to be collected in hopes that it will provide a more nuanced understanding of the clinical behavior of the spectrum of mucinous appendiceal tumors.

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 26839137.001).
  • [ISSN] 1875-9181
  • [Journal-full-title] Surgical pathology clinics
  • [ISO-abbreviation] Surg Pathol Clin
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Keywords] NOTNLM ; Appendiceal adenomas / Mucinous neoplasms / Vermiform appendix
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86. Dupre MP, Jadavji I, Matshes E, Urbanski SJ: Diverticular disease of the vermiform appendix: a diagnostic clue to underlying appendiceal neoplasm. Hum Pathol; 2008 Dec;39(12):1823-6
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  • [Title] Diverticular disease of the vermiform appendix: a diagnostic clue to underlying appendiceal neoplasm.
  • Acquired diverticula of the vermiform appendix are rare and arise as a result of different pathogenetic mechanisms.
  • Although the association of appendiceal diverticulosis and neoplasia is known, it remains underemphasized in the teaching and practice of surgical pathology.
  • To investigate the frequency of appendiceal neoplasms with acquired diverticulosis, we conducted a retrospective analysis of all appendectomy specimens received in our institution for a 55-month period (January 2002-July 2006).
  • Eleven (48%) appendectomy specimens with diverticulosis also harbored an appendiceal neoplasm.
  • The association of appendiceal neoplasms with diverticulosis was statistically significant (P < .0001, 2-sided Fisher exact test).
  • We stress the need for meticulous gross assessment with histologic examination of the entire appendectomy specimen in cases of appendiceal diverticulosis.
  • As acquired diverticula represent a rare finding, examination of the entire appendix in this setting does not create a significant impact on the workload within the pathologic laboratory.
  • [MeSH-major] Adenocarcinoma / pathology. Appendiceal Neoplasms / pathology. Appendix / pathology. Carcinoid Tumor / pathology. Cystadenoma, Mucinous / pathology. Diverticulum / pathology

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  • (PMID = 18715614.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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87. Miyakura Y, Iwai H, Togashi K, Horie H, Nagai H, Kishaba Y, Sato K, Azuma H: Mucinous cystadenocarcinoma of the appendix invading the ascending colon with fistula formation: report of a case. Surg Today; 2007;37(9):806-10
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  • [Title] Mucinous cystadenocarcinoma of the appendix invading the ascending colon with fistula formation: report of a case.
  • Based on colonoscopy findings, we made a preoperative diagnosis of primary mucinous cystadenocarcinoma of the appendix with features of a submucosal tumor (SMT) in the ascending colon.
  • Examination of colonoscopic biopsy specimens indicated "very" well-differentiated adenocarcinoma with mucus lakes.
  • The adjacent appendix had an enhanced wall and unclear border against the ascending colon.
  • Histopathological examination revealed mucinous cystadenocarcinoma of the appendix, invading the ascending colon with fistula formation.
  • Appendiceal tumors can manifest with a variety of colonoscopic features, and curative surgical resection should be attempted even if there is fistula formation.
  • [MeSH-major] Appendix / pathology. Colon / pathology. Colonic Diseases / etiology. Cystadenocarcinoma, Mucinous / complications. Intestinal Fistula / etiology. Mucins

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  • (PMID = 17713739.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Mucins
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88. Pan Z, Repertinger S, Leonard R, Bewtra C, Gatalica Z, Sharma P: Cervical and endometrial metastases of appendiceal goblet cell carcinoid. Arch Pathol Lab Med; 2010 May;134(5):776-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cervical and endometrial metastases of appendiceal goblet cell carcinoid.
  • Appendiceal goblet cell carcinoid (GCC) is a rare tumor with histologic features of both adenocarcinoma and neuroendocrine tumor (carcinoid).
  • Clinically, it behaves more aggressively than classic appendiceal carcinoid and commonly presents with peritoneal carcinomatosis.
  • We report 2 cases of appendiceal GCC, one with uterine cervical involvement and the other with endometrial involvement as the initial presentations.
  • The second patient presented with abnormal uterine bleeding, and endometrial curettage showed an adenocarcinoma with signet ring cell features.
  • Primary appendiceal GCC was demonstrated in both cases after systematic clinical investigations.
  • Metastatic appendiceal GCC to uterine cervix and endometrium can potentially be misinterpreted as primary cervical or endometrial signet ring cell carcinoma.
  • Therefore, for any uterine cervical/endometrial signet ring cell carcinoma, a metastatic appendiceal GCC should be considered in the differential diagnosis, especially after excluding other primary sites.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Carcinoid Tumor / secondary. Endometrial Neoplasms / secondary. Uterine Cervical Neoplasms / secondary


89. Stewart JH 4th, Shen P, Russell GB, Bradley RF, Hundley JC, Loggie BL, Geisinger KR, Levine EA: Appendiceal neoplasms with peritoneal dissemination: outcomes after cytoreductive surgery and intraperitoneal hyperthermic chemotherapy. Ann Surg Oncol; 2006 May;13(5):624-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Appendiceal neoplasms with peritoneal dissemination: outcomes after cytoreductive surgery and intraperitoneal hyperthermic chemotherapy.
  • BACKGROUND: Appendiceal neoplasms frequently present with peritoneal dissemination (PD) and have a clinical course marked by bowel obstruction and subsequent death.
  • Few data have correlated outcome with appendiceal histology after cytoreductive surgery and intraperitoneal hyperthermic chemotherapy (IPHC).
  • We have reviewed our experience with cytoreductive surgery and IPHC for PD from the appendix.
  • METHODS: A total of 110 cases of PD from proven appendiceal neoplasms treated with IPHC were identified from a prospectively managed database.
  • RESULTS: A total of 116 IPHCs were performed on 110 patients for appendiceal PD between 1993 and 2004.
  • Age at presentation (P = .0134), performance status (P < .0001), time between diagnosis and IPHC (P = .0011), resection status (P = .0044), and length of hyperthermic chemoperfusion (P = .0193) were independently associated with survival.
  • CONCLUSIONS: The data show that long-term survival is anticipated in most patients who are treated with cytoreduction and IPHC for appendiceal PD.
  • In all, this work establishes a framework for the consideration of IPHC in future trials for appendiceal PD.
  • [MeSH-major] Adenocarcinoma, Mucinous / drug therapy. Adenocarcinoma, Mucinous / surgery. Appendiceal Neoplasms / pathology. Peritoneal Neoplasms / drug therapy. Peritoneal Neoplasms / surgery

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  • [CommentIn] Ann Surg Oncol. 2006 May;13(5):597-9 [16538404.001]
  • (PMID = 16538401.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / K08 CA131482
  • [Publication-type] Journal Article
  • [Publication-country] United States
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91. To AC, Looi KL, Damianovich D, Taylor GB, Sidebotham D, White HD: A case of cardiogenic shock caused by capecitabine treatment. Nat Clin Pract Cardiovasc Med; 2008 Nov;5(11):725-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: A 52-year-old woman underwent successful resection of stage IIB primary mucinous adenocarcinoma of the appendix and was started on capecitabine chemotherapy.
  • DIAGNOSIS: Capecitabine-induced cardiogenic shock.
  • [MeSH-major] Adenocarcinoma, Mucinous / drug therapy. Antimetabolites, Antineoplastic / adverse effects. Appendiceal Neoplasms / drug therapy. Deoxycytidine / analogs & derivatives. Fluorouracil / analogs & derivatives. Shock, Cardiogenic / chemically induced

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  • (PMID = 18813211.001).
  • [ISSN] 1743-4300
  • [Journal-full-title] Nature clinical practice. Cardiovascular medicine
  • [ISO-abbreviation] Nat Clin Pract Cardiovasc Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Biomarkers; 0 / Cardiotonic Agents; 0W860991D6 / Deoxycytidine; 6804DJ8Z9U / Capecitabine; U3P01618RT / Fluorouracil
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92. McAree BJ, Gilliland R, Campbell DM, Lucas JW, Dickey W: Cerebral air embolism complicating esophagogastroduodenoscopy (EGD). Endoscopy; 2008 Sep;40 Suppl 2:E191-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adenocarcinoma / diagnosis. Aged. Appendiceal Neoplasms / diagnosis. Fatal Outcome. Humans. Male. Tomography, X-Ray Computed

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  • (PMID = 18709611.001).
  • [ISSN] 1438-8812
  • [Journal-full-title] Endoscopy
  • [ISO-abbreviation] Endoscopy
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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93. Moryl N, Coyle N, Foley KM: Managing an acute pain crisis in a patient with advanced cancer: "this is as much of a crisis as a code". JAMA; 2008 Mar 26;299(12):1457-67
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  • [Title] Managing an acute pain crisis in a patient with advanced cancer: "this is as much of a crisis as a code".
  • Using the case of Mr X, a 33-year-old man with advanced metastatic mucinous adenocarcinoma of the appendix and "15 out of 10" pain, we explore the issues of acute pain and its management.
  • Our management strategy focuses on making a pain diagnosis, differentiating reversible from intractable causes of pain, and making decisions about further workup; selecting the opioid and monitoring and treating opioid adverse effects; titrating and rotating opioid and coanalgesics; consulting experts to treat a pain crisis as quickly as possible to prevent unnecessary suffering; and co-opting the available institutional resources.

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  • [ErratumIn] JAMA. 2009 Mar 25;301(12):1230. Dosage error in article text
  • [ErratumIn] JAMA. 2008 May 14;299(18):2150. Dosage error in article text
  • (PMID = 18364488.001).
  • [ISSN] 1538-3598
  • [Journal-full-title] JAMA
  • [ISO-abbreviation] JAMA
  • [Language] ENG
  • [Publication-type] Case Reports; Clinical Conference; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adjuvants, Anesthesia; 0 / Analgesics, Opioid; 0 / Anesthetics, Dissociative; 0 / Anti-Anxiety Agents; 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Glucocorticoids; 12794-10-4 / Benzodiazepines; UC6VBE7V1Z / Methadone
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94. Walters KC, Paton BL, Schmelzer TS, Gersin KS, Iannitti DA, Kercher KW, Heniford BT: Treatment of appendiceal adenocarcinoma in the United States: penetration and outcomes of current guidelines. Am Surg; 2008 Nov;74(11):1066-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Treatment of appendiceal adenocarcinoma in the United States: penetration and outcomes of current guidelines.
  • Current treatment guidelines for appendiceal adenocarcinoma specify that right hemicolectomy should be performed.
  • This study evaluates appendiceal cancer outcomes in the United States and treatment guideline compliance.
  • Data for patients diagnosed with appendiceal adenocarcinoma in the Surveillance, Epidemiology, and End Results database (1988 to 2003) were analyzed.
  • The 2511 patients with appendiceal adenocarcinoma had an average age of 59.3 years, average tumor size of 4.05 cm, and 5-year survival rate of 57 per cent.
  • One-third of patients with adenocarcinoma did not undergo current surgical guideline therapy.
  • The current data raise the question of whether Stage I and II appendiceal cancer can be adequately treated with simple appendectomy.
  • [MeSH-major] Adenocarcinoma / surgery. Appendectomy. Appendiceal Neoplasms / surgery. Colectomy

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  • (PMID = 19062662.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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95. Castellanos JA, Edwards CM, Shaver A, Merchant NB, Parikh AA: Appendiceal adenocarcinoma presenting as venous thromboembolism: an unusual presentation of a rare carcinoma. Am Surg; 2010 May;76(5):543-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Appendiceal adenocarcinoma presenting as venous thromboembolism: an unusual presentation of a rare carcinoma.
  • [MeSH-major] Adenocarcinoma / complications. Adenocarcinoma / diagnosis. Appendiceal Neoplasms / complications. Appendiceal Neoplasms / diagnosis. Venous Thromboembolism / etiology
  • [MeSH-minor] Humans. Male. Middle Aged. Thrombophilia / diagnosis. Thrombophilia / etiology. Thrombophilia / therapy

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  • [Cites] Ann Surg. 2001 Aug;234(2):198-205 [11505065.001]
  • [Cites] Br J Surg. 2004 Mar;91(3):304-11 [14991630.001]
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  • (PMID = 20506889.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / T32 CA106183
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS619862; NLM/ PMC4157457
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96. Agaimy A, Pelz AF, Wieacker P, Roessner A, Wünsch PH, Schneider-Stock R: Gastrointestinal stromal tumors of the vermiform appendix: clinicopathologic, immunohistochemical, and molecular study of 2 cases with literature review. Hum Pathol; 2008 Aug;39(8):1252-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gastrointestinal stromal tumors of the vermiform appendix: clinicopathologic, immunohistochemical, and molecular study of 2 cases with literature review.
  • Gastrointestinal stromal tumors (GIST) are rare in the vermiform appendix.
  • Here, we report 2 appendiceal gastrointestinal stromal tumors in a 78-year-old woman and a 72-year-old man with a history of endometrial adenocarcinoma and urinary bladder carcinoma, respectively.
  • We suggest that the molecular pathogenesis of appendiceal gastrointestinal stromal tumors beyond initiating KIT mutations might be different from their gastric and intestinal counterparts.
  • The coincidence of loss of p16 and overexpression of human telomerase reverse transcriptase seems to be in contradiction to the small size, the benign nature, and the limited growth potential of appendiceal gastrointestinal stromal tumors.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Gastrointestinal Stromal Tumors / pathology

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  • (PMID = 18547614.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
  • [Number-of-references] 21
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97. Gerritsen KG, Slee PH, Bollen TL, van Hecke W, Seldenrijk CA, Keijsers RG, Duurkens VA: Recurrent pneumonia due to an appendiceal mucinous cystadenocarcinoma: a rare presentation of a rare malignancy. Clin Med Oncol; 2009;3:9-12
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  • [Title] Recurrent pneumonia due to an appendiceal mucinous cystadenocarcinoma: a rare presentation of a rare malignancy.
  • Mucinous cystadenocarcinoma of the appendix is a rare malignancy.
  • This is a report of a 74-year-old man who presented with recurrent pneumonia which turned out to be a postobstructive pneumonia complicating a large mucinous cystadenocarcinoma of the appendix with massive retroperitoneal and intrathoracic extension.
  • Mucinous cystadenocarcinoma of the appendix is a low-grade malignancy characterized by expansive growth due to progressive accumulation of mucinous fluid produced by the cancer cells.
  • The unusual retroperitoneal location of appendix in this patient probably allowed the tumor to expand massively in the retroperitoneal space and the thoracic cavity.
  • The value of (18)F-FDG PET in the diagnosis of mucinous cystadenocarcinoma of the appendix has not been determined yet, but it might be promising.
  • To the knowledge of the authors, this is the first report of an appendiceal mucinous cystadenocarcinoma with expansion into the thoracic cavity presenting with recurrent pneumonia.

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  • (PMID = 20689604.001).
  • [ISSN] 1177-9314
  • [Journal-full-title] Clinical medicine. Oncology
  • [ISO-abbreviation] Clin Med Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] New Zealand
  • [Other-IDs] NLM/ PMC2872597
  • [Keywords] NOTNLM ; appendiceal neoplasms / mucinous adenocarcinoma / recurrent pneumonia / transdiaphragmatic lung invasion
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98. Terada T: Non-invasive Adenocarcinoma of the Vermiform Appendix: Incidence and Report of Four Cases among 512 Appendectomies. Gastroenterology Res; 2009 Aug;2(4):238-241
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Non-invasive Adenocarcinoma of the Vermiform Appendix: Incidence and Report of Four Cases among 512 Appendectomies.
  • : Tumors of the vermiform appendix are relatively rare.
  • More than 50% of appendiceal tumors are carcinoid tumors.
  • The author reviewed 512 consecutive pathological specimens of appendectomies in last ten years in our pathology laboratory in search for appendiceal tumors.
  • As the results, 4 cases (incidence: 0.8%) of non-invasive adenocarcinoma were found.
  • The age of the 4 patients with adenocarcinoma was 48, 39, 84 and 86 years, respectively.
  • Pathologically, all the 4 tumors were non-invasive adenocarcinomas: 2 cases were flat type adenocarcinoma, 1 case was papillary adenocarcinoma, and 1 case was mucinous adenocarcinoma.
  • The results suggest that incidence of appendiceal adenocarcinoma was 0.8% of all appendectomies, and that non-invasive adenocarcinoma of the appendix shows variable morphologies, and that postoperative clinical outcome of non-invasive appendiceal tumor is good.

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  • (PMID = 27942282.001).
  • [ISSN] 1918-2805
  • [Journal-full-title] Gastroenterology research
  • [ISO-abbreviation] Gastroenterology Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Keywords] NOTNLM ; Adenocarcinoma / Appendix / Histopathology / Non-invasive carcinoma / appendicitis
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99. Vang R, Gown AM, Barry TS, Wheeler DT, Yemelyanova A, Seidman JD, Ronnett BM: Cytokeratins 7 and 20 in primary and secondary mucinous tumors of the ovary: analysis of coordinate immunohistochemical expression profiles and staining distribution in 179 cases. Am J Surg Pathol; 2006 Sep;30(9):1130-9
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  • We report analysis of both coordinate expression profiles and staining distribution in 179 rigorously classified mucinous tumors in the ovary, including 53 primary tumors [35 atypical proliferative (borderline) mucinous tumors of gastrointestinal type and 18 invasive mucinous carcinomas] and 126 secondary tumors [28 colorectal adenocarcinomas, 54 appendiceal tumors (23 adenocarcinomas, 31 low-grade adenomatous mucinous tumors associated with pseudomyxoma peritonei), 14 pancreatic adenocarcinomas, 8 endocervical adenocarcinomas, 5 gastric adenocarcinomas, 4 gallbladder/biliary tract adenocarcinomas, and 13 adenocarcinomas of unknown primary sites).
  • A CK7+/CK20+ immunoprofile was the most common profile in primary ovarian tumors (74%), upper gastrointestinal tract tumors (78%), and endocervical tumors (88%) but was occasionally observed in lower intestinal tract tumors (colorectal: 11%; appendiceal: 13% of low-grade tumors, 35% of carcinomas).
  • For CK7+ tumors, staining distribution was very frequently diffuse (>50% of tumors cells positive) in primary ovarian, upper gastrointestinal tract, and endocervical tumors, whereas staining distribution was often focal (<50% of tumors cells positive) when present in colorectal and appendiceal carcinomas but not in low-grade appendiceal tumors.
  • [MeSH-major] Adenocarcinoma, Mucinous / chemistry. Keratins / analysis. Ovarian Neoplasms / chemistry
  • [MeSH-minor] Adenocarcinoma / chemistry. Coloring Agents. Female. Gastrointestinal Neoplasms / chemistry. Humans. Immunohistochemistry. Keratin-20. Keratin-7. Pseudomyxoma Peritonei / complications. Uterine Cervical Neoplasms / chemistry

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  • (PMID = 16931958.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Coloring Agents; 0 / KRT20 protein, human; 0 / KRT7 protein, human; 0 / Keratin-20; 0 / Keratin-7; 68238-35-7 / Keratins
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100. Rao P, Pinheiro N Jr, Franco M, Ra S, Costa H, Manzano J, Paner GP, Silva EG, Amin MB: Pseudomyxoma peritonei associated with primary mucinous borderline tumor of the renal pelvicalyceal system. Arch Pathol Lab Med; 2009 Sep;133(9):1472-6
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  • A pathologic diagnosis of intraepithelial carcinoma arising in a mucinous neoplasm of borderline malignancy was rendered.
  • This case illustrates that, in a patient with pseudomyxoma peritonei, the absence of an appendiceal, gastrointestinal, or ovarian primary tumor raises the possibility of a primary neoplasm at an unusual site such as the kidney.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Kidney Neoplasms / pathology. Peritoneal Neoplasms / pathology. Pseudomyxoma Peritonei / pathology

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  • (PMID = 19722758.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Mucins
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