[X] Close
You are about to erase all the values you have customized, search history, page format, etc.
Click here to RESET all values       Click here to GO BACK without resetting any value
Items 1 to 89 of about 89
1. Francisco JS, Alfaro SE, Oliveira DC, Tonon S, Dias EP: Apocrine carcinoma in the parotid gland and in the submandibular region. Braz J Otorhinolaryngol; 2005 Mar-Apr;71(2):224-7
MedlinePlus Health Information. consumer health - Oral Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Apocrine carcinoma in the parotid gland and in the submandibular region.
  • The objectives of this paper are to report a case of apocrine carcinoma and the discussion of aspects related to its diagnosis, treatment, and prognosis.
  • Carcinomas with apocrine differentiation not related to extramammary Paget's disease, ductal breast carcinoma, Moll's glands adenocarcinoma and ceruminous glands carcinoma are very uncommon tumors.
  • We report a case of a 51-year-old black woman who developed apocrine carcinoma lesions in the head and neck region.
  • Two lesions involved her left parotid gland (first tumor and local recurrence), and other involved her submandibular skin.
  • The microscopic aspects were as follows: infiltrative glandular epithelial neoplasm with moderate cellular and nuclear pleomorphism; neoplasic cells with polygonal or circular shape, large nuclei and eosinophilic and granular cytoplasm.
  • The apical decapitation secretion was viewed in a large number of intra-cystic tumor cells.
  • Based on cutaneous apocrine carcinoma compatibility of the microscopic aspects, we concluded that the tumor in the submandibular skin was probably the primary neoplasm.
  • [MeSH-major] Apocrine Glands. Carcinoma / pathology. Mouth Neoplasms / pathology. Sweat Gland Neoplasms / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16446921.001).
  • [ISSN] 1808-8694
  • [Journal-full-title] Brazilian journal of otorhinolaryngology
  • [ISO-abbreviation] Braz J Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Brazil
  •  go-up   go-down


2. Hatanaka K, Tanimoto A, Umekita Y, Yoshioka T, Kanekura T: Unusual anogenital apocrine tumor resembling mammary-like gland adenoma in male perineum: a case report. Diagn Pathol; 2010;5:42
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Unusual anogenital apocrine tumor resembling mammary-like gland adenoma in male perineum: a case report.
  • A rare case of an apocrine tumor in the male perineal region is reported.
  • The cystic lesion, measuring 3.5 x 5.0 cm in size, was lined by columnar or flattened epithelium with occasional apocrine features and supported by a basal myoepithelium lining.
  • A mural nodule, measuring 1 x 1.5 cm in size, protruded into the cystic space and consisted of a solid proliferation of tubular glands with prominent apocrine secretion and basal myoepithelial cells.
  • Although no mammary-like glands were present in the dermis around the tumor, this unusual apocrine tumor has been suggested to be derived from male anogenital mammary-like glands and mimic a mammary-like gland adenoma in the male perineum.
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Humans. Immunohistochemistry. Male

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Clin Exp Dermatol. 2001 Jan;26(1):88-92 [11260187.001]
  • [Cites] J Cutan Pathol. 2004 Sep;31(8):561-4 [15268713.001]
  • [Cites] Am J Obstet Gynecol. 1971 Jun 15;110(4):501-8 [4325819.001]
  • [Cites] Am J Dermatopathol. 1988 Feb;10(1):28-35 [2459984.001]
  • [Cites] Am J Surg Pathol. 1991 Sep;15(9):835-41 [1951842.001]
  • [Cites] J Cutan Pathol. 1992 Feb;19(1):73-9 [1556271.001]
  • [Cites] Pathology. 2009;41(4):372-8 [19404851.001]
  • [Cites] J Cutan Pathol. 1997 Apr;24(4):249-55 [9138118.001]
  • [Cites] J Urol. 1998 Jun;159(6):1918-20 [9598487.001]
  • [Cites] J Cutan Pathol. 1999 Jul;26(6):295-300 [10472758.001]
  • [Cites] J Cutan Pathol. 2006 Jan;33(1):43-6 [16441411.001]
  • [Cites] Eur J Dermatol. 2006 Sep-Oct;16(5):576-8 [17101482.001]
  • [Cites] Am J Dermatopathol. 1991 Dec;13(6):557-67 [1666822.001]
  • (PMID = 20576161.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC2907321
  •  go-up   go-down


3. Carvalho J, Fullen D, Lowe L, Su L, Ma L: The expression of CD23 in cutaneous non-lymphoid neoplasms. J Cutan Pathol; 2007 Sep;34(9):693-8
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In our routine practice, we observed that CD23 reacted strongly with eccrine and apocrine secretory coils.
  • METHODS: Immunohistochemical staining of CD23 was performed in a total of 131 cases of apocrine, eccrine, follicular and other cutaneous non-lymphoid tumors.
  • RESULTS: CD23 expression was detected in all benign apocrine tumors and in half of benign eccrine tumors, particularly those derived from secretory coils.
  • CD23 staining was seen in 42% (8/19) of microcystic adnexal carcinoma (MAC), while no staining was observed in tumor cells of desmoplastic trichoepithelioma, morpheaform basal cell carcinoma and syringoma.
  • CONCLUSION: CD23 appears to be a reliable immunohistochemical marker of the eccrine/apocrine secretory coil and helpful in identifying sweat gland tumors of such origin.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Neoplasms, Adnexal and Skin Appendage / metabolism. Receptors, IgE / metabolism. Sweat Gland Neoplasms / metabolism
  • [MeSH-minor] Apocrine Glands / metabolism. Apocrine Glands / pathology. Eccrine Glands / metabolism. Eccrine Glands / pathology. Humans

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17696916.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Receptors, IgE
  •  go-up   go-down


Advertisement
4. Tanaka A, Kimura A, Yamamoto Y, Uede K, Furukawa F: Expression of histo-blood group A type 1, 2 and 3 antigens in normal skin and extramammary Paget's disease. Acta Histochem Cytochem; 2008 Dec 27;41(6):165-71
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of histo-blood group A type 1, 2 and 3 antigens in normal skin and extramammary Paget's disease.
  • The distribution of histo-blood group A type 1, 2 and 3 antigens was investigated using immunohistochemistry in normal human skin and extramammary Paget's disease (EMPD).
  • Apocrine glands, hair follicles and sebaceous glands did not express these antigens.
  • Since these antigens were localized in the eccrine glands, we examined the possibility of a skin tumor marker.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Arch Pathol Lab Med. 1979 Oct;103(11):586-90 [226027.001]
  • [Cites] Eur J Biochem. 1981 Nov;120(2):243-9 [6172274.001]
  • [Cites] Bull Cancer. 1983;70(2):127-31 [6871487.001]
  • [Cites] Nature. 1990 May 17;345(6272):229-33 [2333095.001]
  • [Cites] Nihon Hifuka Gakkai Zasshi. 1986 Jun;96(7):705-10 [3761675.001]
  • [Cites] Cancer Res. 1987 Mar 15;47(6):1695-700 [3815366.001]
  • [Cites] Int J Cancer. 1989 May 15;43(5):774-80 [2497072.001]
  • [Cites] Proc Natl Acad Sci U S A. 1985 Feb;82(4):1199-203 [2579390.001]
  • [Cites] Eur J Cancer. 1974 Aug;10(8):487-90 [4463000.001]
  • [Cites] Vox Sang. 1989;56(1):1-20 [2464874.001]
  • [Cites] Cancer. 1985 Sep 1;56(5):1147-62 [2990667.001]
  • [Cites] Br J Cancer. 1988 Sep;58(3):373-8 [2846025.001]
  • [Cites] FEBS Lett. 1985 Jan 1;179(1):165-72 [3965299.001]
  • [Cites] Am J Pathol. 1984 Dec;117(3):451-61 [6507589.001]
  • [Cites] J Histochem Cytochem. 1990 Dec;38(12):1815-21 [2254646.001]
  • [Cites] Am J Dermatopathol. 1993 Oct;15(5):435-40 [7694516.001]
  • [Cites] J Gastroenterol. 1994 Jun;29(3):265-75 [8061795.001]
  • [Cites] J Cutan Pathol. 1997 Apr;24(4):249-55 [9138118.001]
  • [Cites] Arch Pathol Lab Med. 1998 Nov;122(11):957-65 [9822123.001]
  • [Cites] J Exp Med. 1960 Jun 1;111:785-800 [13774694.001]
  • [Cites] Cancer Res. 1971 Sep;31(9):1244-50 [4940062.001]
  • [Cites] Arch Pathol Lab Med. 2001 Apr;125(4):498-505 [11260623.001]
  • [Cites] APMIS. 2001 Jan;109(1):9-31 [11297197.001]
  • [Cites] J Cancer Res Clin Oncol. 2000 Jul;126(7):375-82 [10929759.001]
  • [Cites] Biochim Biophys Acta. 1999 Dec 6;1473(1):247-66 [10580143.001]
  • [Cites] J Histochem Cytochem. 2008 Mar;56(3):223-31 [17998569.001]
  • [Cites] Eur Respir J. 2007 Feb;29(2):268-72 [17005587.001]
  • [Cites] J Dent Res. 2005 Jan;84(1):21-8 [15615870.001]
  • (PMID = 19180201.001).
  • [ISSN] 0044-5991
  • [Journal-full-title] Acta histochemica et cytochemica
  • [ISO-abbreviation] Acta Histochem Cytochem
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Other-IDs] NLM/ PMC2629552
  • [Keywords] NOTNLM ; eccrine glands / extramammary Paget’s disease / histo-blood group A type 1/2 antigens / histo-blood group A type 3 antigens
  •  go-up   go-down


5. Sakuma A, Nishiyama S, Yasuno K, Ohmuro T, Kamiie J, Shirota K: A case of canine cutaneous clear cell adnexal carcinoma with prominent expression of smooth muscle actin. J Toxicol Pathol; 2010 Dec;23(4):265-9
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Histologically, the tumor mostly consisted of neoplastic cells with clear or vacuolated cytoplasms and contained frequent tubular structures.
  • In addition, immunohistochemistry revealed that the tumor cells were positive for pan-CK (AE1/AE3, KL1, CAM 5.2), CK-7, CK-8, CK-14, CK-15, CK-18, vimentin and alpha-smooth muscle actin (SMA) with varied intensity and positivity.
  • Among these marker proteins, SMA was positive in 75% of the tumor cells.
  • On the other hand, CK-15, which is a specific marker of follicular stem cells, was expressed in less than 1% of the tumor cells.
  • Based on these findings, the tumor showed diverse differentiation in apocrine sweat glands and the inner and outer root sheaths of hair follicles, indicating the follicular stem cell to be the origin of this tumor.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 22272037.001).
  • [ISSN] 1881-915X
  • [Journal-full-title] Journal of toxicologic pathology
  • [ISO-abbreviation] J Toxicol Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Other-IDs] NLM/ PMC3234631
  • [Keywords] NOTNLM ; cytokeratin / dermatopathology / dog / skin / skin tumor / stem cell
  •  go-up   go-down


6. Kato K, Uchida K, Nibe K, Tateyama S: Immunohistochemical studies on cytokeratin 8 and 18 expressions in canine cutaneous adnexus and their tumors. J Vet Med Sci; 2007 Mar;69(3):233-9
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The expressions of cytokeratin 8 and 18 (CK8 and CK18) in the normal canine skin (2 cases) and cutaneous adnexal tumors (127 cases) were investigated immunohistochemically.
  • In the normal skin, co-expression of CK8/18 was found in the glandular epithelium of apocrine sweat glands, and single CK8-immunoreactivity was detected occasionally in the external root sheath at the isthmus and suprabulbar regions of the hair follicles.
  • Neoplastic glandular epithelial cells in all apocrine gland tumors (21/21 cases, 100%) had co-expression of CK8/18.
  • In several cases of trichoblastomas (4/28 cases, 14%) and trichoepitheliomas (2/19 cases, 11%), tumor cells forming glandular structures had co-expression of CK8/18.
  • The present findings indicate that co-expression of CK8/18 is a specific feature of apocrine sweat glands and single CK8-expression represents the natures of external root sheath or pluripotential stem cells.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17409637.001).
  • [ISSN] 0916-7250
  • [Journal-full-title] The Journal of veterinary medical science
  • [ISO-abbreviation] J. Vet. Med. Sci.
  • [Language] ENG
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Keratin-18; 0 / Keratin-8
  •  go-up   go-down


7. Crain N, Nelson BL, Barnes EL, Thompson LD: Ceruminous gland carcinomas: a clinicopathologic and immunophenotypic study of 17 cases. Head Neck Pathol; 2009 Mar;3(1):1-17

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Ceruminal gland carcinomas are rare neoplasms confined to the skin lining the cartilaginous part of the external auditory canal.
  • Histologic features included a dual cell population (although not the dominant histology), increased cellularity, moderate to severe nuclear pleomorphism, irregular nucleoli, increased mitotic figures (mean, 3/10 HPF), including atypical forms, and tumor necrosis (n = 2).
  • CONCLUSION: Ceruminous-type carcinomas, with the exception of ceruminous mucoepidermoid carcinoma, all demonstrated a dual cell population of basal myoepithelial-type cells and luminal apocrine cells.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Disease-Free Survival. Female. Humans. Immunohistochemistry. Male. Middle Aged. Otorhinolaryngologic Surgical Procedures. Radiotherapy. Retrospective Studies

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] J Thorac Cardiovasc Surg. 1973 Jun;65(6):909-13 [4350087.001]
  • [Cites] J Laryngol Otol. 1973 Dec;87(12):1201-10 [4357381.001]
  • [Cites] J Laryngol Otol. 1974 Apr;88(4):363-8 [4824672.001]
  • [Cites] Can J Otolaryngol. 1974;3(2):194-201 [4831936.001]
  • [Cites] Arch Otolaryngol. 1974 Nov;100(5):395-7 [4429488.001]
  • [Cites] Cancer. 1975 Sep;36(3):1072-6 [171051.001]
  • [Cites] J Laryngol Otol. 1975 Jul;89(7):707-20 [171328.001]
  • [Cites] Arch Otolaryngol. 1975 Nov;101(11):702-5 [1200915.001]
  • [Cites] Laryngoscope. 1977 Oct;87(10 Pt 1):1601-12 [198620.001]
  • [Cites] J Can Assoc Radiol. 1977 Dec;28(4):287-90 [303644.001]
  • [Cites] Cancer. 1978 Feb;41(2):545-53 [630537.001]
  • [Cites] Arch Otolaryngol. 1980 Jan;106(1):13-9 [6243462.001]
  • [Cites] Ann Otol Rhinol Laryngol. 1990 Sep;99(9 Pt 1):714-21 [2396807.001]
  • [Cites] Neurol Med Chir (Tokyo). 1990 Dec;30(13):1034-7 [1714051.001]
  • [Cites] Otolaryngol Head Neck Surg. 1992 Feb;106(2):214-5 [1310808.001]
  • [Cites] Acta Morphol Hung. 1991;39(2):157-65 [1789146.001]
  • [Cites] J Laryngol Otol. 1992 Aug;106(8):727-32 [1328435.001]
  • [Cites] Pathology. 1992 Oct;24(4):315-9 [1337771.001]
  • [Cites] Rev Laryngol Otol Rhinol (Bord). 1993;114(1):49-52 [8191051.001]
  • [Cites] J Laryngol Otol. 1994 Aug;108(8):706-9 [7930929.001]
  • [Cites] Cancer. 1982 Dec 15;50(12):2873-83 [6291744.001]
  • [Cites] J Laryngol Otol. 1995 Mar;109(3):180-8 [7745330.001]
  • [Cites] Am J Dermatopathol. 1995 Apr;17(2):169-73 [8600783.001]
  • [Cites] J Laryngol Otol. 1996 Mar;110(3):249-51 [8730361.001]
  • [Cites] J Am Anim Hosp Assoc. 1996 Sep-Oct;32(5):448-52 [8875362.001]
  • [Cites] Indian J Cancer. 1997 Sep;34(3):139-42 [9491676.001]
  • [Cites] Br J Plast Surg. 1998 Jun;51(4):317-20 [9771352.001]
  • [Cites] J Laryngol Otol. 1957 Dec;71(12):824-31 [13491925.001]
  • [Cites] J Laryngol Otol. 1957 Dec;71(12):832-7 [13491926.001]
  • [Cites] Cancer. 1964 Jan;17:67-75 [14102073.001]
  • [Cites] J Otolaryngol. 1980 Dec;9(6):482-6 [6162967.001]
  • [Cites] J Laryngol Otol. 1981 Aug;95(8):843-8 [6267150.001]
  • [Cites] J Neurosurg. 1981 Dec;55(6):952-6 [7299469.001]
  • [Cites] Am J Clin Pathol. 1982 Feb;77(2):153-61 [7039299.001]
  • [Cites] Laryngoscope. 1983 Mar;93(3):326-40 [6300574.001]
  • [Cites] Hiroshima J Med Sci. 1984 Mar;33(1):17-22 [6090347.001]
  • [Cites] J Am Acad Dermatol. 1984 Nov;11(5 Pt 1):841-7 [6096419.001]
  • [Cites] Laryngoscope. 1987 Feb;97(2):158-64 [3807618.001]
  • [Cites] Am J Otol. 1987 Nov;8(6):485-8 [3434612.001]
  • [Cites] Cancer. 1989 Dec 1;64(11):2292-302 [2804921.001]
  • [Cites] J R Soc Med. 1990 Jan;83(1):34-7 [2406442.001]
  • [Cites] J Laryngol Otol. 1999 Jun;113(6):578-80 [10605594.001]
  • [Cites] J Otolaryngol. 2001 Dec;30(6):373-7 [11771014.001]
  • [Cites] Arch Pathol Lab Med. 2002 Jan;126(1):87-9 [11800656.001]
  • [Cites] J Oral Maxillofac Surg. 2002 Apr;60(4):465-9 [11928113.001]
  • [Cites] Mod Pathol. 2002 May;15(5):543-55 [12011260.001]
  • [Cites] Arch Otolaryngol Head Neck Surg. 2002 Jul;128(7):834-7 [12117346.001]
  • [Cites] ORL J Otorhinolaryngol Relat Spec. 2002 Sep-Oct;64(5):358-63 [12417781.001]
  • [Cites] J Laryngol Otol. 2003 Mar;117(3):202-4 [12648377.001]
  • [Cites] Am J Otolaryngol. 2003 Jul-Aug;24(4):274-7 [12884224.001]
  • [Cites] Acta Otorhinolaryngol Ital. 2004 Dec;24(6):354-6 [15952686.001]
  • [Cites] Ear Nose Throat J. 2005 Sep;84(9):560-1 [16261754.001]
  • [Cites] Otol Neurotol. 2006 Jan;27(1):97-101 [16371854.001]
  • [Cites] Indian J Pathol Microbiol. 2006 Oct;49(4):587-9 [17183866.001]
  • [Cites] Acta Otolaryngol. 2007 Mar;127(3):280-4 [17364365.001]
  • [Cites] Otolaryngol Head Neck Surg. 2007 Dec;137(6):893-8 [18036417.001]
  • [Cites] J Neurosurg. 2008 Jan;108(1):97-104 [18173317.001]
  • [Cites] B-ENT. 2007;3(4):195-9 [18265725.001]
  • [Cites] Arch Otolaryngol Head Neck Surg. 2008 Jun;134(6):663-6 [18559737.001]
  • [Cites] Laryngoscope. 2008 Sep;118(9):1591-6 [18677277.001]
  • [Cites] Auris Nasus Larynx. 2003 Aug;30(3):287-90 [12927294.001]
  • [Cites] Acta Cytol. 2003 Sep-Oct;47(5):792-4 [14526681.001]
  • [Cites] ORL J Otorhinolaryngol Relat Spec. 2003 Sep-Oct;65(5):300-2 [14730188.001]
  • [Cites] J Laryngol Otol. 2003 Dec;117(12):951-4 [14738604.001]
  • [Cites] Am J Surg Pathol. 2004 Mar;28(3):308-18 [15104293.001]
  • [Cites] Arch Otolaryngol. 1967 Jul;86(1):66-9 [6026961.001]
  • [Cites] Arch Dermatol. 1968 Oct;98(4):344-8 [4300211.001]
  • [Cites] Arch Otolaryngol. 1970 Jul;92(1):40-2 [4192890.001]
  • [Cites] J Laryngol Otol. 1970 Jul;84(7):743-5 [5432829.001]
  • [Cites] Pract Otorhinolaryngol (Basel). 1970;32(4):211-8 [5477506.001]
  • [Cites] Cancer. 1971 Sep;28(3):775-80 [4328926.001]
  • [Cites] Tex Med. 1970 Oct;66(10):56-9 [4335213.001]
  • [Cites] Cancer. 1972 May;29(5):1169-78 [5021609.001]
  • (PMID = 20596983.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC2807538
  • [Keywords] NOTNLM ; Adenoid cystic / Carcinoma / Ceruminal / Ceruminous / Ear / Gland / Immunohistochemistry / Mucoepidermoid / Prognosis
  •  go-up   go-down


8. Magro G, Floridia F, Geraci G, Marino B: Lipomatous apocrine mixed tumor of the skin: an unusual giant lesion occurring in the breast. J Cutan Pathol; 2009 Jun;36(6):692-6
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Lipomatous apocrine mixed tumor of the skin: an unusual giant lesion occurring in the breast.
  • Apart this unusual clinical presentation, another intriguing feature of tumor was the histological picture, being composed of an extensive mature fatty stromal component closely intermingling with the epithelial structures.
  • As adipocytes were variable in size and focally showed a lipoblast-like appearance, some tumor areas were reminiscent of a well-differentiated liposarcoma, lipoma-like.
  • Based on the histological features, the term 'lipomatous mixed tumor, apocrine type' was proposed for such a lesion.
  • Histogenetic considerations about the lipomatous stromal component of the tumor are provided.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Breast Neoplasms / pathology. Lipoma / pathology. Neoplasms, Complex and Mixed / pathology. Skin Neoplasms / pathology

  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19515050.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  •  go-up   go-down


9. Shimato S, Wakabayashi T, Mizuno M, Nakahara N, Hatano H, Natsume A, Ishii D, Hasegawa Y, Hyodo I, Nagasaka T, Yoshida J: Brain metastases from apocrine carcinoma of the scalp: case report. J Neurooncol; 2006 May;77(3):285-9
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Brain metastases from apocrine carcinoma of the scalp: case report.
  • Apocrine carcinoma is an extremely rare malignant neoplasm that occurs most frequently in the axilla.
  • However, a literature search did not reveal any report describing the detailed clinical course of brain metastases from apocrine carcinoma.
  • We report a case of a 54-year-old male who suffered from multiple brain metastases from apocrine carcinoma that had originated in the scalp 6 years before.
  • The tumor in the right frontal lobe was successfully operated.
  • However, the small tumor in the right occipital lobe was not cured by gamma knife surgery, and eventually required second operation.
  • To our knowledge this is the first reported case of metastatic brain tumor from apocrine carcinoma.
  • [MeSH-major] Apocrine Glands / pathology. Brain Neoplasms / secondary. Carcinoma / secondary. Lung Neoplasms / secondary. Skin Neoplasms / pathology

  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • MedlinePlus Health Information. consumer health - Lung Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16314948.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  •  go-up   go-down


10. Liu HN, Chang YT, Chen CC, Yang AH: Facial apocrine fibroadenoma in man: a rare finding. Am J Dermatopathol; 2007 Jun;29(3):274-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Facial apocrine fibroadenoma in man: a rare finding.
  • Apocrine fibroadenoma (AFA), considered a counterpart of fibroadenoma of breast, is a rare cutaneous apocrine neoplasm occurring almost exclusively in women.
  • The tumor was composed of numerous tubular, cystic, and partially branching lumina and struts of epithelial cells oriented perpendicular to the skin surface, with which it connected through infundibula.
  • The cytokeratin profiles of our case were similar to those of apocrine or eccrine neoplasms.
  • Different from a more common anogenital AFA, this neoplasm might represent a second type of AFA with unique histopathologic and immunopathological features.
  • [MeSH-major] Apocrine Glands / pathology. Fibroadenoma / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Humans. Immunohistochemistry. Male. Treatment Outcome

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17519626.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  •  go-up   go-down


11. Kruse AL, Zwahlen R, Bredell MG, Riener MO, Grätz KW: Apocrine hidrocystoma of the cheek. J Craniofac Surg; 2010 Mar;21(2):594-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Apocrine hidrocystoma of the cheek.
  • BACKGROUND: Apocrine hidrocystoma is an uncommon benign cystic proliferation of the apocrine sweat glands.
  • An exocrine tumor or, more unlikely, a melanoma was considered as a differential diagnosis.
  • Pathologically, the lesion was determined to be an apocrine hidrocystoma.
  • [MeSH-minor] Diagnosis, Differential. Follicular Cyst / diagnosis. Hemangioma / diagnosis. Humans. Male. Melanoma / diagnosis. Middle Aged. Skin Diseases / diagnosis

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20489460.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


12. Miyamoto T, Inoue S, Adachi K, Takada R: Differential expression of mucin core proteins and keratins in apocrine carcinoma, extramammary Paget's disease and apocrine nevus. J Cutan Pathol; 2009 May;36(5):529-34
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Differential expression of mucin core proteins and keratins in apocrine carcinoma, extramammary Paget's disease and apocrine nevus.
  • BACKGROUND: Apocrine carcinomas are rare, the immunohistochemical characterizations that are incomplete.
  • The purpose of this study was to determine the immunohistochemical characteristics of mucin core proteins and keratins in apocrine carcinoma, extramammary Paget's disease (EMPD) and apocrine nevus.
  • METHODS: We report four cases of apocrine carcinomas along with immunohistochemical analyses: (i) an axillary apocrine carcinoma with an apocrine nevus, (ii) an inguinal apocrine carcinoma, (iii) a vulvar apocrine carcinoma with EMPD and (iv) an axillary apocrine carcinoma with EMPD and an apocrine nevus.
  • RESULTS: The tumor cells of apocrine carcinomas, EMPD and apocrine nevi displayed a positive reaction to MUC-1 and CK7 and a negative reaction to CK20.
  • Apocrine carcinomas had high molecular weight (HMW) cytokeratin(+)/CK5(+)/CK14(-)/MUC5AC(-), EMPD with underlying apocrine carcinoma had HMW cytokeratin(-)/CK5(-)/CK14(-)/MUCA5AC(-) and the apocrine nevi had HMW cytokeratin(+)/CK5(+)/CK14(+)/MUCA5AC(+).
  • CONCLUSION: The immunohistochemical findings suggest that apocrine carcinomas, apocrine nevi and EMPD with underlying apocrine carcinomas are quite different, even though they are all derived from apocrine glands.
  • [MeSH-major] Carcinoma, Skin Appendage / metabolism. Keratins / biosynthesis. Mucins / biosynthesis. Nevus / metabolism. Paget Disease, Extramammary / metabolism. Sweat Gland Neoplasms / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Apocrine Glands / metabolism. Apocrine Glands / pathology. Biomarkers, Tumor / analysis. Humans. Immunohistochemistry. Male

  • Genetic Alliance. consumer health - Nevus.
  • MedlinePlus Health Information. consumer health - Birthmarks.
  • MedlinePlus Health Information. consumer health - Moles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19476520.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Mucins; 68238-35-7 / Keratins
  •  go-up   go-down


13. Yu DK, Joo YH, Cho KH: Trichoblastoma with apocrine and sebaceous differentiation. Am J Dermatopathol; 2005 Feb;27(1):6-8
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Trichoblastoma with apocrine and sebaceous differentiation.
  • Trichoblastoma is a rare, benign tumor that differentiates toward the hair germ, the embryonic precursor of a hair follicle.
  • An immunohistochemical study showed that the neoplasm, or areas in it, stained positive for low molecular cytokeratin, high molecular cytokeratin, EMA, S-100, and GCDFP-15.
  • This is an unusual case of a trichoblastoma with apocrine and sebaceous differentiation.
  • [MeSH-major] Apocrine Glands / pathology. Hair Diseases / pathology. Hair Follicle / pathology. Neoplasms, Adnexal and Skin Appendage / pathology. Sebaceous Glands / pathology
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Cell Transformation, Neoplastic. Female. Humans. Immunohistochemistry. Middle Aged. Treatment Outcome

  • MedlinePlus Health Information. consumer health - Hair Problems.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15677969.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  •  go-up   go-down


14. Usui K, Ochiai T, Abe I, Nishio H, Togo K, Yamagata M: Apocrine gland carcinoma of the mammary skin concomitant with pagetoid phenomenon. J Dermatol; 2010 Apr;37(4):350-4
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Apocrine gland carcinoma of the mammary skin concomitant with pagetoid phenomenon.
  • We reported a 52-year-old woman with an apocrine gland carcinoma of the mammary skin concomitant with pagetoid phenomenon.
  • Our diagnosis revealed that the nodule was an apocrine gland carcinoma and the intraepidermal neoplastic cells with pagetoid spread in the pigmented plaque were derived from the apocrine gland carcinoma.
  • No Paget's cells were detected in the right nipple, and no tumor cells were observed in the sentinel lymph node and underlying mammary gland tissue.
  • They showed that both intraepidermal neoplastic cells with pagetoid spread and tumor cells of the apocrine gland carcinoma were positive with cytokeratin-7 and human epidermal growth factor receptor-2 (HER-2)/neu overexpression.
  • The results of the present study conclude that the intraepithelial spread of tumor cells in the mammary skin distant from the nipple occurred as a pagetoid phenomenon, and that HER-2 may have a key role in pagetoid phenomenon of an underlying apocrine gland carcinoma, as well as in mammary Paget's disease.
  • [MeSH-major] Apocrine Glands / pathology. Breast Neoplasms / pathology. Carcinoma / pathology. Paget's Disease, Mammary / pathology. Sweat Gland Neoplasms / pathology

  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20507405.001).
  • [ISSN] 1346-8138
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Keratin-7; EC 2.7.10.1 / ERBB2 protein, human; EC 2.7.10.1 / Receptor, ErbB-2
  •  go-up   go-down


15. Kazakov DV, Belousova IE, Bisceglia M, Calonje E, Emberger M, Grayson W, Hantschke M, Kempf W, Kutzner H, Michal M, Spagnolo DV, Virolainen S, Zelger B: Apocrine mixed tumor of the skin ("mixed tumor of the folliculosebaceous-apocrine complex"). Spectrum of differentiations and metaplastic changes in the epithelial, myoepithelial, and stromal components based on a histopathologic study of 244 cases. J Am Acad Dermatol; 2007 Sep;57(3):467-83
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Apocrine mixed tumor of the skin ("mixed tumor of the folliculosebaceous-apocrine complex"). Spectrum of differentiations and metaplastic changes in the epithelial, myoepithelial, and stromal components based on a histopathologic study of 244 cases.
  • BACKGROUND: A systematic analysis of the entire spectrum of various forms of differentiation and metaplastic epiphenomena in cutaneous apocrine mixed tumor (AMT) has never been performed.
  • RESULTS: All types of differentiation along the lines of the folliculosebaceous-apocrine unit can be seen in AMT.
  • We propose that the most appropriate name for these lesions is "mixed tumor of the folliculosebaceous-apocrine complex. "
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Apocrine Glands. Skin Neoplasms / pathology. Sweat Gland Neoplasms / pathology

  • MedlinePlus Health Information. consumer health - Skin Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17707152.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 104
  •  go-up   go-down


16. Baran JL, Hoang MP: Apocrine mixed tumor of the skin with a prominent pilomatricomal component. J Cutan Pathol; 2009 Aug;36(8):882-6
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Apocrine mixed tumor of the skin with a prominent pilomatricomal component.
  • Pilomatrical differentiation within an apocrine mixed tumor (AMT) when present is only focal and has not been reported to be extensive.
  • Histologic sections revealed, underneath a neurofibroma, a well-circumscribed tumor composed of nodules of branching epithelial elements and occasional keratinous cysts within a myxoid and lipomatous stroma.
  • In approximately 50% of the tumor, eosinophilic ghost/shadow cells associated with a foreign body giant cell reaction formed a nodule resembling a pilomatricoma.
  • The presence of follicular and apocrine differentiation within our tumor reinforces the common embryologic derivation of these elements.
  • [MeSH-major] Apocrine Glands / pathology. Facial Neoplasms / pathology. Mixed Tumor, Malignant / pathology. Pilomatrixoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Cell Differentiation. Cysts / metabolism. Cysts / pathology. Humans. Male. Middle Aged. Neoplasm Proteins / biosynthesis. Neurofibroma / metabolism. Neurofibroma / pathology

  • MedlinePlus Health Information. consumer health - Skin Cancer.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19586498.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Neoplasm Proteins
  •  go-up   go-down


17. Zelger BG, Stelzmueller I, Dunst KM, Zelger B: Solid apocrine carcinoma of the skin: report of a rare adnexal neoplasm mimicking lobular breast carcinoma. J Cutan Pathol; 2008 Mar;35(3):332-6
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Solid apocrine carcinoma of the skin: report of a rare adnexal neoplasm mimicking lobular breast carcinoma.
  • The so called 'sweat gland carcinoma' is a rare skin malignancy.
  • The differentiation between apocrine and eccrine neoplasms remains difficult.
  • Skin tumors of the axilla are often suspected to be metastasis of other neoplasms in particular breast cancer.
  • After further clinical and laboratory work up including immunohistochemistry the original diagnosis of a breast cancer had to be changed to solid apocrine carcinoma of the skin.
  • Final tumor stage was pT2 N0 M0 (V0 L0).
  • Solid apocrine carcinoma of the skin is a rare variant with apocrine differentiation.
  • A survey of the stereotypical presentation of this lesion and a comparison with lobular breast carcinoma and other types of apocrine carcinoma of the skin is given.
  • [MeSH-major] Adenocarcinoma / diagnosis. Apocrine Glands / pathology. Breast Neoplasms, Male / diagnosis. Carcinoma, Lobular / diagnosis. Sweat Gland Neoplasms / diagnosis
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Diagnosis, Differential. Disease-Free Survival. Humans. Immunohistochemistry. Male

  • MedlinePlus Health Information. consumer health - Male Breast Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18251751.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  •  go-up   go-down


18. Bujas T, Pavić I, Lenicek T, Mijić A, Kruslin B, Tomas D: Axillary apocrine carcinoma associated with apocrine adenoma and apocrine gland hyperplasia. Acta Dermatovenerol Croat; 2007;15(3):148-51

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Axillary apocrine carcinoma associated with apocrine adenoma and apocrine gland hyperplasia.
  • Apocrine carcinomas represent a rare group of tumors with a potential for destructive local invasion, regional and distant metastases, and are equally common in both sexes.
  • A case of a 79-year-old woman with axillary apocrine carcinoma associated with apocrine adenoma and apocrine gland hyperplasia is presented.
  • Grossly, the tumor measured 3.2x1.5x1.2 cm and on cut section appeared granular, white to gray-tanned.
  • Microscopically, the tumor was located in the dermis, poorly demarcated, focally necrotic with ulcerated overlying skin.
  • The cells contained abundant eosinophilic, finely granular cytoplasm with pleomorphic nuclei and showed apocrine-like decapitation.
  • In one area, the tumor was lobular and composed of tubular structures lined with one layer of uniform cuboidal or columnar eosinophilic cells, indicating a pre-existing apocrine adenoma.
  • Beneath the tumor, in the deep dermis and subcutaneous tissue, hyperplastic apocrine glands were also found.
  • No additional therapy was used, and one year after the surgery the patient was alive and showed no signs of tumor spread.
  • This and previously reported cases suggest that apocrine hyperplasia and apocrine adenoma may represent successive steps in the development of apocrine carcinoma.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Apocrine Glands / pathology. Sweat Gland Neoplasms / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17868540.001).
  • [ISSN] 1330-027X
  • [Journal-full-title] Acta dermatovenerologica Croatica : ADC
  • [ISO-abbreviation] Acta Dermatovenerol Croat
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
  •  go-up   go-down


19. Misago N, Narisawa Y: Cytokeratin 15 expression in apocrine mixed tumors of the skin and other benign neoplasms with apocrine differentiation. J Dermatol; 2006 Jan;33(1):2-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytokeratin 15 expression in apocrine mixed tumors of the skin and other benign neoplasms with apocrine differentiation.
  • To clarify the features of apocrine mixed tumors (AMT) of the skin among benign neoplasms with apocrine differentiation in their relationship to follicular stem cells, we investigated the immunohistochemical expression of CK15 (LHK15 and C8/144B), which is a relatively specific marker of hair follicle stem cells in the bulge, in 35 cases of eight different benign neoplasms with presumed apocrine differentiation.
  • All eight cases of AMT of the skin showed CK15 immunostaining of the neoplastic cells, and all four cases of syringocystadenoma papilliferum, all five cases of spiradenoma, and both cases of cylindroma also showed a focally positive reaction to CK15.
  • None of the other benign neoplasms with presumed apocrine differentiation showed CK15 expression.
  • In AMT of the skin, the proportion of CK15-positive cells in the follicular or sebaceous differentiation group (78.8%, average of four cases) was significantly higher than the group without this differentiation (8.8%, average of four cases).
  • AMT of the skin are unique among benign neoplasms with apocrine differentiation in their substantial and constant CK15 expression, suggesting that they derive from multipotent epithelial stem cells in the bulge.
  • AMT of the skin with follicular or sebaceous differentiation are considered to show an immature stage of apocrine differentiation still rich in stem cells or to originate from stem cells with an incompletely established apocrine fate.
  • The partially positive reaction for CK15 in syringocystadenomas papilliferum and spiradenoma/cylindroma may depend on the ability to express CK15 in stem cells with an apocrine fate or result from the follicular and apocrine nature of this neoplasm.
  • [MeSH-major] Apocrine Glands / metabolism. Keratins / metabolism. Sweat Gland Neoplasms / metabolism
  • [MeSH-minor] Adenoma, Sweat Gland / metabolism. Adult. Aged. Biomarkers, Tumor. Case-Control Studies. Cystadenoma / metabolism. Female. Humans. Immunohistochemistry. Male. Middle Aged

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16469077.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 68238-35-7 / Keratins
  •  go-up   go-down


20. Kazakov DV, Kutzner H, Spagnolo DV, Kempf W, Zelger B, Mukensnabl P, Michal M: Sebaceous differentiation in poroid neoplasms: report of 11 cases, including a case of metaplastic carcinoma associated with apocrine poroma (sarcomatoid apocrine porocarcinoma). Am J Dermatopathol; 2008 Feb;30(1):21-6
Zurich Open Access Repository and Archive. Full text from .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sebaceous differentiation in poroid neoplasms: report of 11 cases, including a case of metaplastic carcinoma associated with apocrine poroma (sarcomatoid apocrine porocarcinoma).
  • We describe 11 poroid neoplasms with sebaceous differentiation, including a metaplastic (sarcomatoid) carcinoma arising in association with an apocrine poroma.
  • Six lesions had the silhouette of a classical poroma, 3 of poroid hidradenoma and 1 of dermal duct tumor.
  • The single carcinoma was an ulcerated oval to spindle cell neoplasm surrounded laterally by the residuum of a poroma containing groups of sebocytes.
  • Our study supports previous findings that sebaceous differentiation can be identified not only in classical poroma but also in the related lesions known as dermal duct tumor and poroid hidradenoma.
  • Occurrence of metaplastic carcinoma in association with apocrine poroma is a rare event which indicates the existence of a malignant counterpart of the latter entity, which can be descriptively referred to as "sarcomatoid apocrine porocarcinoma. "
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Neoplasms, Multiple Primary / pathology. Sarcoma / pathology. Sebaceous Glands / pathology. Skin Neoplasms / pathology

  • MedlinePlus Health Information. consumer health - Skin Cancer.
  • MedlinePlus Health Information. consumer health - Soft Tissue Sarcoma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18212539.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


21. Charfi S, Sevestre H, Dumont F, Regimbeau JM, Chatelain D: Atypical apocrine proliferation involving anogenital mammary-like glands of the perianal region. J Cutan Pathol; 2009 Oct;36 Suppl 1:52-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atypical apocrine proliferation involving anogenital mammary-like glands of the perianal region.
  • Histopathological examination of the excised lesion showed atypical apocrine proliferation arising in a complex lesion with features of fibroadenoma, adenosis and hyperplastic and cystic change.
  • Normal MLGs were observed at the tumor periphery.
  • [MeSH-major] Apocrine Glands / pathology. Genitalia, Female / pathology. Mammary Glands, Human / pathology. Neoplasms, Adnexal and Skin Appendage / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19775395.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  •  go-up   go-down


22. Fischer S, Breuninger H, Metzler G, Hoffmann J: Microcystic adnexal carcinoma: an often misdiagnosed, locally aggressive growing skin tumor. J Craniofac Surg; 2005 Jan;16(1):53-8
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Microcystic adnexal carcinoma: an often misdiagnosed, locally aggressive growing skin tumor.
  • Recently it has been proposed that MAC is an apocrine tumor.
  • The authors report the case of a 78-year-old woman in whom a diagnosis of MAC was made when a tumor on the right cheek recurred for the second time.
  • Local recurrences of the tumor occurred, despite histographic surgery because in hematoxylin and eosin stains, small islands of the deceptively benign-appearing small basaloid cells of MAC were not recognized as tumor cells.
  • [MeSH-major] Carcinoma, Skin Appendage / pathology. Facial Neoplasms / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Carcinoma, Squamous Cell / pathology. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Neoplasm Invasiveness. Neoplasm Recurrence, Local / pathology. Neoplasms, Basal Cell / pathology

  • Genetic Alliance. consumer health - Microcystic adnexal carcinoma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15699645.001).
  • [ISSN] 1049-2275
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


23. Morandi F, Benazzi C, Simoni P: Adenocarcinoma of apocrine sweat glands in a mouflon (Ovis musimon). J Vet Diagn Invest; 2005 Jul;17(4):389-92

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenocarcinoma of apocrine sweat glands in a mouflon (Ovis musimon).
  • Ultrastructurally, the cytoplasm of the neoplastic cells contained numerous pleomorphic secretory granules and microvilli, which partially covered the luminal surface of the tumor cells.
  • On the basis of histological and ultrastructural findings, this tumor was diagnosed as a tubulopapillary adenocarcinoma, arising from apocrine sweat glands of the skin.
  • [MeSH-major] Adenocarcinoma / veterinary. Apocrine Glands. Sheep Diseases / diagnosis. Sweat Gland Neoplasms / veterinary

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16131002.001).
  • [ISSN] 1040-6387
  • [Journal-full-title] Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
  • [ISO-abbreviation] J. Vet. Diagn. Invest.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


24. Kazakov DV, Bisceglia M, Spagnolo DV, Kutzner H, Belousova IE, Hes O, Sima R, Vanecek T, Yang Y, Michal M: Apocrine mixed tumors of the skin with architectural and/or cytologic atypia: a retrospective clinicopathologic study of 18 cases. Am J Surg Pathol; 2007 Jul;31(7):1094-102
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Apocrine mixed tumors of the skin with architectural and/or cytologic atypia: a retrospective clinicopathologic study of 18 cases.
  • We present a series of 18 atypical apocrine mixed tumors of the skin characterized by architectural and/or cytologic atypia but which nevertheless do not qualify these lesions as carcinomas.
  • There were 15 males and 3 females, and all but 1 presented with solitary nodules ranging in size from 4 to 20 mm; 1 female had a large tumor of 12 cm.
  • As controls, 4 authentic malignant mixed tumors were studied, but these likewise tested negative for HER-2/neu protein expression and showed no gene amplification; 1 malignant mixed tumor had polysomy 17.
  • We conclude that some atypical cytoarchitectural features in apocrine mixed tumors, albeit worrisome, do not indicate a malignant change.
  • [MeSH-major] Apocrine Glands / pathology. Neoplasms, Complex and Mixed / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / analysis. Female. Humans. Male. Middle Aged. Retrospective Studies

  • COS Scholar Universe. author profiles.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17592277.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  •  go-up   go-down


25. Swick BL, Baum CL, Walling HW: Rippled-pattern trichoblastoma with apocrine differentiation arising in a nevus sebaceus: report of a case and review of the literature. J Cutan Pathol; 2009 Nov;36(11):1200-5
Genetic Alliance. consumer health - Nevus.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Rippled-pattern trichoblastoma with apocrine differentiation arising in a nevus sebaceus: report of a case and review of the literature.
  • Histologic sections of the papular growth at the superior pole of the nevus sebaceus showed a proliferation of cytologically bland basaloid epithelial tumor lobules both in the superficial dermis, with multiple connections to the epidermis, and within the deeper dermis in a nodular growth pattern demonstrating papillary mesenchymal bodies.
  • Ductal structures with apocrine-type decapitation secretion were present.
  • The histologic features resembled those of rippled-pattern trichoblastoma with apocrine differentiation arising in a nevus sebaceus, an association not previously described.
  • [MeSH-major] Neoplasms, Adnexal and Skin Appendage / complications. Neoplasms, Adnexal and Skin Appendage / pathology. Nevus, Sebaceous of Jadassohn / complications

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19469871.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Denmark
  • [Number-of-references] 32
  •  go-up   go-down


26. Honma N, Takubo K, Arai T, Younes M, Kasumi F, Akiyama F, Sakamoto G: Comparative study of monoclonal antibody B72.3 and gross cystic disease fluid protein-15 as markers of apocrine carcinoma of the breast. APMIS; 2006 Oct;114(10):712-9
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparative study of monoclonal antibody B72.3 and gross cystic disease fluid protein-15 as markers of apocrine carcinoma of the breast.
  • Gross cystic disease fluid protein-15 (GCDFP-15) is a commonly used apocrine marker; however, its expression was recently found to decrease in infiltrating, larger, or metastasizing apocrine carcinomas of the breast.
  • In the breast, monoclonal antibody (MAb) B72.3 has been reported to be useful as an apocrine marker although it is used for that purpose much less frequently than GCDFP-15.
  • In the search for a more consistent apocrine marker, immunoreactivity for MAb B72.3 was examined in apocrine carcinomas at different stages and compared with GCDFP-15.
  • 47 of 51 apocrine carcinomas (92%) and 9 of 62 ordinary carcinomas (15%) were MAb B72.3 positive, while 39 of 51 apocrine carcinomas (76%) and 13 of 62 ordinary carcinomas (21%) were GCDFP-15 positive.
  • Furthermore, unlike GCDFP-15, MAb B72.3 exhibited positivity irrespective of infiltrating status, tumor size, or metastatic status.
  • The combined usage of MAb B72.3 with GCDFP-15 was useful to confirm the diagnosis of apocrine carcinoma, especially for advanced tumors, with only two cases being negative for both MAb B72.3 and GCDFP-15.
  • Whether these two cases should be differentiated from ordinary apocrine carcinomas remains to be investigated.
  • [MeSH-major] Apocrine Glands / pathology. Biomarkers, Tumor / metabolism. Breast Neoplasms / metabolism. Breast Neoplasms / secondary. Carcinoma, Ductal, Breast / metabolism. Carcinoma, Ductal, Breast / secondary. Carcinoma, Intraductal, Noninfiltrating / metabolism. Carcinoma, Intraductal, Noninfiltrating / secondary. Carrier Proteins / metabolism. Glycoproteins / metabolism. Immunohistochemistry / methods. Skin Neoplasms / pathology

  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17004974.001).
  • [ISSN] 0903-4641
  • [Journal-full-title] APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
  • [ISO-abbreviation] APMIS
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Biomarkers, Tumor; 0 / Carrier Proteins; 0 / Glycoproteins; 0 / PIP protein, human
  •  go-up   go-down


27. Fernandez-Flores A: Mammaglobin immunostaining in the differential diagnosis between cutaneous apocrine carcinoma and cutaneous metastasis from breast carcinoma. Cesk Patol; 2009 Oct;45(4):108-12
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mammaglobin immunostaining in the differential diagnosis between cutaneous apocrine carcinoma and cutaneous metastasis from breast carcinoma.
  • The differential diagnosis between cutaneous apocrine carcinoma (CAC) and cutaneous metastases from breast carcinoma is commonly difficult.
  • Although, more cases of CAC should probably be studied in the future before any categorical conclusion can be obtained, our results seem to indicate that a pattern of immunostaining with expression of mammaglobin in many cells would favor a metastatic origin of the tumor.
  • [MeSH-major] Apocrine Glands. Biomarkers, Tumor / analysis. Breast Neoplasms / pathology. Neoplasm Proteins / analysis. Skin Neoplasms / diagnosis. Skin Neoplasms / secondary. Sweat Gland Neoplasms / diagnosis. Sweat Gland Neoplasms / secondary. Uteroglobin / analysis

  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20301838.001).
  • [ISSN] 1210-7875
  • [Journal-full-title] Československá patologie
  • [ISO-abbreviation] Cesk Patol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Czech Republic
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Mammaglobin A; 0 / Neoplasm Proteins; 0 / SCGB2A2 protein, human; 9060-09-7 / Uteroglobin
  •  go-up   go-down


28. Vazmitel M, Michal M, Mukensnabl P, Kazakov DV: Syringocystadenoma papilliferum with sebaceous differentiation in an intradermal tubular apocrine component. Report of a case. Am J Dermatopathol; 2008 Feb;30(1):51-3
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Syringocystadenoma papilliferum with sebaceous differentiation in an intradermal tubular apocrine component. Report of a case.
  • Syringocystadenoma papilliferum is a benign tumor most commonly located on the scalp or face, and it often arises within a nevus sebaceus of Jadassohn.
  • We describe a 61-year-old man with syringocystadenoma papilliferum developing within a nevus sebaceus with sebaceous differentiation in an intradermal tubular apocrine component of the syringocystadenoma papilliferum.
  • Although some adnexal neoplasms that develop in association with a nevus sebaceus may exhibit conjoint sebaceous, follicular, or apocrine differentiation, reflecting close embryological relations of the folliculosebaceous-apocrine unit, the feature we report on has not previously been described to the best of our knowledge.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Head and Neck Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Nevus, Sebaceous of Jadassohn / pathology. Skin Neoplasms / pathology. Sweat Gland Neoplasms / pathology

  • Genetic Alliance. consumer health - Syringocystadenoma papilliferum.
  • MedlinePlus Health Information. consumer health - Head and Neck Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18212545.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


29. Wahl CE, Todd DH, Binder SW, Cassarino DS: Apocrine hidradenocarcinoma showing Paget's disease and mucinous metaplasia. J Cutan Pathol; 2009 May;36(5):582-5
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Apocrine hidradenocarcinoma showing Paget's disease and mucinous metaplasia.
  • He had no history of skin cancer.
  • An excisional biopsy of the lesion showed a fairly well-circumscribed but focally invasive tumor consisting of areas of typical-appearing clear cell hidradenoma as well as areas with mucinous goblet-type cells and cells with eosinophilic cytoplasm and decapitation-type secretion.
  • The tumor cells focally involved the overlying epidermis (Paget's disease).
  • The tumor cells stained with markers for cytokeratin 7 and focally for EMA and CEA, confirming ductal differentiation.
  • [MeSH-major] Apocrine Glands / pathology. Carcinoma, Skin Appendage / pathology. Mucins / metabolism. Paget Disease, Extramammary / pathology. Sweat Gland Neoplasms / pathology

  • Genetic Alliance. consumer health - Hidradenocarcinoma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19476529.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen; 0 / Keratin-7; 0 / Mucin-1; 0 / Mucins
  •  go-up   go-down


30. Rütten A, Kutzner H, Mentzel T, Hantschke M, Eckert F, Angulo J, Rodríguez Peralto JL, Requena L: Primary cutaneous cribriform apocrine carcinoma: a clinicopathologic and immunohistochemical study of 26 cases of an under-recognized cutaneous adnexal neoplasm. J Am Acad Dermatol; 2009 Oct;61(4):644-51

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary cutaneous cribriform apocrine carcinoma: a clinicopathologic and immunohistochemical study of 26 cases of an under-recognized cutaneous adnexal neoplasm.
  • BACKGROUND: Cribriform carcinoma is the histopathologic variant of cutaneous apocrine carcinoma characterized by interconnected solid aggregations of neoplastic cells that are punctuated by small round spaces.
  • OBJECTIVE: To describe the histopathologic and immunohistochemical characteristics of this under-recognized cutaneous adnexal neoplasm.
  • METHODS: Twenty-six cases of primary cutaneous cribriform apocrine carcinoma were clinically, histopathologically, and immunohistochemically studied.
  • CONCLUSIONS: Primary cutaneous cribriform apocrine carcinoma is a distinctive but little-known variant of cutaneous apocrine carcinoma.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Biomarkers, Tumor / metabolism. Neoplasms, Adnexal and Skin Appendage / metabolism. Neoplasms, Adnexal and Skin Appendage / pathology
  • [MeSH-minor] Adult. Aged. Apocrine Glands / pathology. Biopsy. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Adenoid Cystic / pathology. Cytoplasm / pathology. Cytoplasm / ultrastructure. Diagnosis, Differential. Epithelial Cells / pathology. Epithelial Cells / ultrastructure. Female. Humans. Immunohistochemistry. Male. Microscopy, Electron. Microvilli / pathology. Microvilli / ultrastructure. Middle Aged. Young Adult

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [CommentIn] J Am Acad Dermatol. 2011 Mar;64(3):599-601 [21315957.001]
  • (PMID = 19751882.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  •  go-up   go-down


31. Biernat W: Lipomatous mixed tumor of the skin. Am J Dermatopathol; 2008 Jun;30(3):284-6
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Lipomatous mixed tumor of the skin.
  • An unusual tumor of the neck in a 56-year-old female is reported.
  • The tumor was composed of tubules and small cords of epithelial cells dispersed in the fibromyxoid and adipose stroma.
  • At the periphery, the tumor was not encapsulated and its border was intermingled with the subcutaneous fat.
  • Lack of decapitation secretion and the absence of long tubules suggested an eccrine origin; however, in some of the tumor areas, the cells showed brightly eosinophilic copious cytoplasm that may indicate an apocrine differentiation.
  • As an area of chondroid metaplasia was identified, the diagnosis of a mixed tumor was rendered.
  • This unusual type of skin adnexal neoplasm with unique relation of the epithelial component to the surrounding adipose tissue requires differentiation with the primary cutaneous and metastatic carcinomas.
  • [MeSH-major] Adipose Tissue / pathology. Head and Neck Neoplasms / diagnosis. Lipoma / pathology. Neoplasms, Complex and Mixed / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adipocytes / pathology. Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Keratins / analysis. Middle Aged. Neoplasm Metastasis / diagnosis

  • MedlinePlus Health Information. consumer health - Head and Neck Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18496435.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 68238-35-7 / Keratins
  •  go-up   go-down


32. Kasashima S, Hiroshi M, Toshinori M, Yoshio O: Lipomatous mixed tumor with follicular differentiation of the skin. J Cutan Pathol; 2006 May;33(5):389-94
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Lipomatous mixed tumor with follicular differentiation of the skin.
  • A very rare case of cutaneous mixed tumor with numerous adipose tissue and hair follicular structures in a 67-year-old Japanese male was reported.
  • A well-circumscribed tumor was in the subcutaneous tissue of the cheek and far from the parotid gland.
  • Histologically, the tumor consisted of an admixture of the adipose tissue, fibromyxoid tissue with spindle cells, and branching tubular structures.
  • Outer layers of ductal epithelial cells and single spindle cells were often in a transition, likely as typical mixed tumor.
  • To our knowledge, this tumor is the first case of a lipomatous mixed tumor with hair follicular differentiation.
  • The case indicates an additional wide spectrum of histologic appearances of cutaneous mixed tumor.
  • [MeSH-major] Adipose Tissue / pathology. Hair Follicle / pathology. Mixed Tumor, Malignant / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Apocrine Glands / pathology. Biomarkers, Tumor / analysis. Hair Diseases / metabolism. Hair Diseases / pathology. Humans. Immunohistochemistry. Male

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16640549.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  •  go-up   go-down


33. Puri PK, Galan A, Glusac EJ, Cowper SE: Metastatic cutaneous carcinoid tumor mimicking an adnexal poroid neoplasm. J Cutan Pathol; 2008 Jan;35(1):54-7
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic cutaneous carcinoid tumor mimicking an adnexal poroid neoplasm.
  • Herein, we report an unusual case of metastatic cutaneous carcinoid tumor mimicking an adnexal poroid neoplasm.
  • METHODS: A 53-year-old male man presented with a neoplasm on the vertex of the scalp, clinically resembling a pigmented basal cell carcinoma.
  • RESULTS: A shave biopsy was suggestive of an apocrine poroma, however, a metastatic carcinoma could not be excluded.
  • After acquiring additional clinical information and the complete excision of the neoplasm, further immunohistochemical stains supported the diagnosis a metastatic carcinoid tumor.
  • CONCLUSION: To our knowledge, this is the first case of metastatic carcinoid tumor reported that has mimicked a poroid neoplasm.
  • [MeSH-major] Adenoma, Sweat Gland / diagnosis. Apocrine Glands / pathology. Carcinoid Tumor / diagnosis. Skin Neoplasms / diagnosis. Sweat Gland Neoplasms / diagnosis
  • [MeSH-minor] Biomarkers, Tumor / analysis. Diagnosis, Differential. Humans. Male. Middle Aged

  • Genetic Alliance. consumer health - Carcinoid Tumor.
  • MedlinePlus Health Information. consumer health - Carcinoid Tumors.
  • MedlinePlus Health Information. consumer health - Skin Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18095995.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  •  go-up   go-down


34. Saraiva AL, Gärtner F, Pires MA: Expression of p63 normal canine skin and primary cutaneous glandular carcinomas. Vet J; 2008 Jul;177(1):136-40
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of p63 normal canine skin and primary cutaneous glandular carcinomas.
  • In this study, expression of p63 was determined in 31 primary cutaneous glandular carcinomas, including sebaceous, perianal (hepatoid) gland, apocrine and ceruminous carcinomas, as well as their adjacent normal skin.
  • Similar to humans, p63 is a reliable marker for basal and myoepithelial cells in canine epidermis, cutaneous appendages and malignant apocrine and ceruminous gland neoplasms.
  • [MeSH-major] Dog Diseases / metabolism. Epidermis / metabolism. Neoplasms, Glandular and Epithelial / veterinary. Skin Neoplasms / veterinary. Tumor Suppressor Proteins / metabolism
  • [MeSH-minor] Animals. Biomarkers, Tumor / metabolism. Dogs. Gene Expression Regulation, Neoplastic. Genes, Tumor Suppressor. Immunohistochemistry / veterinary. Trans-Activators. Transcription Factors

  • MedlinePlus Health Information. consumer health - Skin Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17804265.001).
  • [ISSN] 1090-0233
  • [Journal-full-title] Veterinary journal (London, England : 1997)
  • [ISO-abbreviation] Vet. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / TP63 protein, human; 0 / Trans-Activators; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins
  •  go-up   go-down


35. Nair PS: A clinicopathologic study of skin appendageal tumors. Indian J Dermatol Venereol Leprol; 2008 Sep-Oct;74(5):550
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A clinicopathologic study of skin appendageal tumors.
  • BACKGROUND: Appendageal skin tumors belong to a heterogenous group of tumors with specific histopathology.
  • The aim of this study is to determine the pattern of appendageal tumors in skin biopsies done in our department.
  • METHODS: This is a 3-year retrospective descriptive study of all patients who were diagnosed to have skin appendageal tumors in our department, and the diagnoses were confirmed by histopathology.
  • The tumors were classified as eccrine, hair, sebaceous, and apocrine after a detailed examination of routine hematoxylin and eosin sections.
  • Tumors with eccrine differentiation constituted the maximum, 17 cases (51.5%); followed by tumors with hair differentiation, 12 cases (36.36%); tumors with sebaceous differentiation, 2 cases (6.06%); and apocrine tumors, 2 cases (6.06%).
  • Syringoma constituted the commonest eccrine tumor, 14 cases (42.42%); while trichoepithelioma was the commonest hair tumor, 9 cases (27.27%).
  • Syringocystadenoma papilliferum, 1 (3.03%); and cylindroma, 1 (3.03%), constituted the apocrine tumors.
  • CONCLUSIONS: Appendageal skin tumors are relatively uncommon.
  • No tumor showed malignant change in this study.
  • [MeSH-major] Carcinoma, Skin Appendage / pathology. Skin Neoplasms / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19086136.001).
  • [ISSN] 0973-3922
  • [Journal-full-title] Indian journal of dermatology, venereology and leprology
  • [ISO-abbreviation] Indian J Dermatol Venereol Leprol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] India
  •  go-up   go-down


36. Kazakov DV, Kutzner H, Mukensnabl P, Michal M: Low-grade adnexal carcinoma of the skin with multidirectional (glandular, trichoblastomatous, spiradenocylindromatous) differentiation. Am J Dermatopathol; 2006 Aug;28(4):341-5
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Low-grade adnexal carcinoma of the skin with multidirectional (glandular, trichoblastomatous, spiradenocylindromatous) differentiation.
  • The conjoint occurrence of follicular, sebaceous, or apocrine differentiations in a cutaneous adnexal neoplasm is a known event, more often encountered in benign neoplasms, whereas reports of cutaneous malignant adnexal tumors with bilineage or trilineage differentiation are few.
  • A new case of a cutaneous malignant adnexal neoplasm with multidirectional differentiation is reported here.
  • A 57-year-old woman presented with a long-standing, slowly growing, asymptomatic solitary tumor the size of a large nut in the coccygeal area, which was surgically excised.
  • Microscopically, the neoplasm was located in the dermis with focal extension into the subcutis.
  • We classified this tumor as a well-differentiated adnexal carcinoma demonstrating combined follicular and apocrine differentiation.
  • It differs from previously published cases of malignant adnexal tumors with multidirectional differentiation and further exemplifies the spectrum of diversity encountered in malignant proliferations with differentiation toward the folliculosebaceous-apocrine unit.
  • [MeSH-major] Adnexal Diseases / pathology. Cell Differentiation. Skin Neoplasms / pathology
  • [MeSH-minor] Cell Shape. Female. Humans. Immunohistochemistry. Middle Aged. Neoplasm Invasiveness / pathology. Neoplasm Staging

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16871040.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


37. Ivan D, Nash JW, Prieto VG, Calonje E, Lyle S, Diwan AH, Lazar AJ: Use of p63 expression in distinguishing primary and metastatic cutaneous adnexal neoplasms from metastatic adenocarcinoma to skin. J Cutan Pathol; 2007 Jun;34(6):474-80
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Use of p63 expression in distinguishing primary and metastatic cutaneous adnexal neoplasms from metastatic adenocarcinoma to skin.
  • p63, a recently identified homologue of the p53 gene, is mainly expressed by basal and myoepithelial cells in skin.
  • Others and we have shown the value of p63 in distinguishing primary adnexal tumors from visceral adenocarcinomas metastatic to skin.
  • We now investigate the pattern of p63 expression in metastases from skin adnexal carcinomas and their cognate primaries and evaluate p63 expression in a larger case series of malignant cutaneous adnexal neoplasms.
  • Twenty visceral metastatic adenocarcinomas to the skin and 7 primary mucinous carcinomas with cutaneous or visceral origin were compared.
  • Metastases from two apocrine carcinomas lacked p63 expression.
  • Analysis of p63 expression may assist in the differential diagnosis of primary adnexal carcinomas versus metastatic visceral adenocarcinomas to the skin.
  • [MeSH-major] Adenocarcinoma, Mucinous / metabolism. Biomarkers, Tumor / metabolism. DNA-Binding Proteins / metabolism. Neoplasms, Adnexal and Skin Appendage / metabolism. Skin Neoplasms / metabolism. Trans-Activators / metabolism. Tumor Suppressor Proteins / metabolism

  • MedlinePlus Health Information. consumer health - Skin Cancer.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [CommentIn] J Cutan Pathol. 2008 Jul;35(7):692-3 [18312438.001]
  • (PMID = 17518775.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / TP63 protein, human; 0 / Trans-Activators; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins
  •  go-up   go-down


38. Ishida M, Katsura K, Nagata A, Kijima K, Kushima R, Okabe H: [A case of primary mucinous carcinoma with endocrine differentiation of the skin]. Rinsho Byori; 2008 Jun;56(6):455-8
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of primary mucinous carcinoma with endocrine differentiation of the skin].
  • Primary mucinous carcinoma of the skin (MCS) is a rare skin appendage tumor and only a few cases of MCS with endocrine differentiation have been reported.
  • Histopathologically, the tumor was located in the dermis and subcutis, and nests of slight atypical epithelial cells were floating in the mucinous pools.
  • This tumor did not accompany carcinoma in situ or invasive non-mucinous carcinoma and was difficult to differentiate from metastatic mucinous carcinoma of the skin.
  • There was no tumor in the other organs and synaptophysin and chromogranin A were sporadically shown immunohistochemically in the tumor cells; a diagnosis of primary pure MCS with endocrine differentiation was made.
  • It is presumed that MCS is derived from the apocrine gland, which is closely related to the mammary gland.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Facial Neoplasms / pathology. Skin Neoplasms / pathology

  • MedlinePlus Health Information. consumer health - Skin Cancer.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18646630.001).
  • [ISSN] 0047-1860
  • [Journal-full-title] Rinsho byori. The Japanese journal of clinical pathology
  • [ISO-abbreviation] Rinsho Byori
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  •  go-up   go-down


39. Kazakov DV, Bisceglia M, Sima R, Michal M: Adenosis tumor of anogenital mammary-like glands: a case report and demonstration of clonality by HUMARA assay. J Cutan Pathol; 2006 Jan;33(1):43-6
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenosis tumor of anogenital mammary-like glands: a case report and demonstration of clonality by HUMARA assay.
  • In mammary pathology, adenosis tumor is defined as a clinically recognizable lesion that histologically primarily consists of adenosis, but also exhibits various combinations of diverse epithelial changes seen in other benign breast diseases.
  • A lesion that occurred in the anogenital area of a 46-year-old woman and apparently arose in anogenital mammary-like glands is described and which, in our opinion, is best classified as adenosis tumor.
  • Several histological patterns within the same tumor mass were recognizable: sclerosing adenosis-like changes, variably sized microcysts and cysts, some with rare short papillary projections having hyalinized cores, rare tubular structures exhibiting epithelial features reminiscent of simple ductal hyperplasia, areas with oxyphilic (apocrine) metaplasia, and clear cell epithelial changes resembling mucinous metaplasia.
  • The cells in the oxyphilic (apocrine) metaplasia areas stained for mitochondrial antigen and Bcl-2.
  • As our case exhibited a number of patterns identical to those seen in diverse benign breast diseases, its classification as adenosis tumor seems justifiable.
  • [MeSH-major] Anus Neoplasms / pathology. Fibrocystic Breast Disease / pathology. Mammary Glands, Human / pathology. Receptors, Androgen / metabolism. Skin Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Clone Cells / metabolism. Clone Cells / pathology. Female. Humans. Middle Aged

  • MedlinePlus Health Information. consumer health - Anal Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16441411.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / AR protein, human; 0 / Biomarkers, Tumor; 0 / Receptors, Androgen
  •  go-up   go-down


40. Weinreb I, O'Malley F, Ghazarian D: Ectopic hamartomatous thymoma: a case demonstrating skin adnexal differentiation with positivity for epithelial membrane antigen, androgen receptors, and BRST-2 by immunohistochemistry. Hum Pathol; 2007 Jul;38(7):1092-5
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ectopic hamartomatous thymoma: a case demonstrating skin adnexal differentiation with positivity for epithelial membrane antigen, androgen receptors, and BRST-2 by immunohistochemistry.
  • Ectopic hamartomatous thymoma is a rare tumor of the lower neck occurring in adult men, which follows a benign course.
  • The origin of this tumor has been debated, but it is now believed to arise from remnants of the cervical sinus of His from early development.
  • We describe a case of ectopic hamartomatous thymoma with typical features, as well as multifocal areas of skin adnexal differentiation.
  • These included sebaceous, eccrine, and apocrine elements.
  • Epithelial membrane antigen stained sebaceous cells and the luminal borders of eccrine and apocrine ducts.
  • BRST-2 and AR stained apocrine elements in a cytoplasmic and a nuclear pattern, respectively.
  • [MeSH-major] Carrier Proteins / metabolism. Glycoproteins / metabolism. Mucin-1 / metabolism. Neoplasms, Adnexal and Skin Appendage / diagnosis. Receptors, Androgen / metabolism. Thymoma / diagnosis

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17574947.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carrier Proteins; 0 / Glycoproteins; 0 / Mucin-1; 0 / PIP protein, human; 0 / Receptors, Androgen
  •  go-up   go-down


41. Thamboo TP, Tan LH, Tan SY: Expression of Bcl-x in normal skin and benign cutaneous adnexal tumors. J Cutan Pathol; 2006 Jan;33(1):27-32
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of Bcl-x in normal skin and benign cutaneous adnexal tumors.
  • METHODS: Tissues from 31 cases of benign cutaneous adnexal tumors (five trichofolliculomas, five trichoepitheliomas, two sebaceous adenomas, five apocrine hidradenomas, five eccrine poromas, five eccrine spiradenomas, and four syringomas) were immunostained for Bcl-x.
  • Apocrine gland cells showed weak to moderate staining.
  • The cells of apocrine hidradenomas showed patchy weak staining.
  • [MeSH-major] Neoplasms, Adnexal and Skin Appendage / metabolism. Skin / metabolism. Skin Neoplasms / metabolism. bcl-X Protein / metabolism
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Epidermis / metabolism. Epidermis / pathology. Humans. Immunoenzyme Techniques. Sebaceous Glands / metabolism. Sebaceous Glands / pathology. Sweat Glands / metabolism. Sweat Glands / pathology

  • MedlinePlus Health Information. consumer health - Skin Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16441408.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / bcl-X Protein
  •  go-up   go-down


42. Mahalingam M, Srivastava A, Hoang MP: Expression of stem-cell markers (cytokeratin 15 and nestin) in primary adnexal neoplasms-clues to etiopathogenesis. Am J Dermatopathol; 2010 Dec;32(8):774-9
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: The overlap in histopathologic features and immunoprofile of eccrine and apocrine neoplasms confounds basic issues relating to lineage of these entities.
  • RESULTS: CK15 and nestin expression were noted in 39 of 78 (50%) and 36 of 78 (46%) cases in the benign group, respectively (8 cutaneous mixed tumor, 10 hidradenoma papilliferum, 9 apocrine cystadenoma, 11 cylindroma and/or spiradenoma, and 9 poroma/dermal duct tumor).
  • Except 1, both markers were negative in 4 syringocystadenoma papilliferum, 10 hidradenoma, 1 syringofibroadenoma, 10 syringoma, 1 eccrine adenoma, 8 poroma/dermal duct tumor, 5 eccrine hidrocystoma, and 1 apocrine carcinoma.
  • CONCLUSIONS: Given that follicular germinative cells give rise to the folliculosebaceous apocrine unit, expression of CK15 and nestin in the majority of cutaneous mixed tumor, hidradenoma papilliferum, apocrine cystadenoma, and cylindroma/spiradenoma is suggestive of an apocrine origin/differentiation of these neoplasms.
  • [MeSH-major] Apocrine Glands / chemistry. Biomarkers, Tumor / analysis. Eccrine Glands / chemistry. Intermediate Filament Proteins / analysis. Keratin-15 / analysis. Neoplasms, Adnexal and Skin Appendage / chemistry. Neoplastic Stem Cells / chemistry. Nerve Tissue Proteins / analysis. Sweat Gland Neoplasms / chemistry

  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20700038.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Intermediate Filament Proteins; 0 / KRT15 protein, human; 0 / Keratin-15; 0 / NES protein, human; 0 / Nerve Tissue Proteins; 0 / Nestin
  •  go-up   go-down


43. Kazakov DV, Mukensnabl P, Michal M: Tubular adenoma of the skin with follicular and sebaceous differentiation: A report of two cases. Am J Dermatopathol; 2006 Apr;28(2):142-6
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tubular adenoma of the skin with follicular and sebaceous differentiation: A report of two cases.
  • The main controversies regarding tubular apocrine adenoma and papillary eccrine adenoma are whether they are two distinct entities or are the very same tumor, and if so, which lineage of differentiation (apocrine versus eccrine) it pursues.
  • The features in both cases indicated apocrine differentiation of the tubular component.
  • In conclusion, these two cases of cutaneous tubular adenoma with accompanying follicular and sebaceous differentiation give further support to the proposition that the majority of these neoplasms have apocrine differentiation.
  • Rare cases occurring in the sites normally devoid of apocrine glands may represent the eccrine counterpart.
  • [MeSH-major] Adenoma / pathology. Skin Neoplasms / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16625077.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


44. Leeborg N, Thompson M, Rossmiller S, Gross N, White C, Gatter K: Diagnostic pitfalls in syringocystadenocarcinoma papilliferum: case report and review of the literature. Arch Pathol Lab Med; 2010 Aug;134(8):1205-9
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • An 86-year-old woman presented with a neoplasm on the neck, and the intralesional heterogeneity typical of these neoplasms led to an initial diagnosis on needle biopsy favoring squamous cell carcinoma.
  • Fortuitous sectioning revealed a focal connection to the skin surface with evidence of apocrine differentiation allowing final diagnosis as syringocystadenocarcinoma papilliferum.
  • We describe our findings and diagnostic pitfalls to help pathologists encountering this unusual apocrine neoplasm.
  • [MeSH-minor] Aged, 80 and over. Biomarkers, Tumor / metabolism. Carcinoma, Squamous Cell / diagnosis. Cell Nucleus / metabolism. Cell Nucleus / pathology. Diagnosis, Differential. Female. Humans. Keratins / metabolism. Membrane Proteins / metabolism. Neoplasm Invasiveness. Neoplasm Recurrence, Local

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20670144.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CKAP4 protein, human; 0 / Membrane Proteins; 68238-35-7 / Keratins
  •  go-up   go-down


45. Reck SJ, Xia L, Dehner LP, Reising CA: Glandular congenital lymphadenoma. Pediatr Dermatol; 2007 Sep-Oct;24(5):547-50
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Cutaneous lymphadenoma is a rare tumor with a distinct histologic triad of epithelial nodules, dense fibrous stroma, and intense intranodular lymphocytic infiltrate.
  • Typically, it is a slow growing, skin colored papule, nodule, or plaque, clinically resembling a basal cell carcinoma and often occurring in the head and neck region or lower extremities.
  • [MeSH-major] Adenolymphoma / pathology. Infant, Newborn, Diseases / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Apocrine Glands / pathology. Biopsy. Female. Humans. Infant, Newborn


46. Apostolou G, Apostolou N, Chatzipantelis P, Biteli M: Spiradenocylindrocarcinoma. Report of a case with a low-grade component of spiradenocarcinoma and an immunohistochemical study. Am J Dermatopathol; 2009 Aug;31(6):594-8
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Spiradenocylindrocarcinoma is a very rare malignant cutaneous neoplasm of the folliculosebaceous-apocrine unit.
  • We report a case of this hybrid tumor in a 42-year-old woman.
  • The tumor consisted of 2 circumscribed nodules with areas of cylindrocarcinoma and low-grade spiradenocarcinoma.
  • Expansion of the tumor beyond the fibrous pseudocapsule into the adjacent tissue was present.
  • Furthermore, tumor cells were demonstrating mild to moderate pleomorphism and an increased mitotic index. p53 and ki-67 were among the positive immunohistochemical markers.
  • A relatively small number of tumor cells expressed estrogen receptors.
  • The aim of this study was to investigate the nature of this rare tumor of the skin appendages.
  • [MeSH-major] Carcinoma, Skin Appendage / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor. Female. Humans. Immunohistochemistry. Neoplasm Recurrence, Local / metabolism. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery

  • MedlinePlus Health Information. consumer health - Skin Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19590412.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  •  go-up   go-down


47. Kim ES, Lee DP, Lee MW, Choi JH, Moon KC, Koh JK: Cutaneous metastasis of uterine papillary serous carcinoma. Am J Dermatopathol; 2005 Oct;27(5):436-8
MedlinePlus Health Information. consumer health - Uterine Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A 54-year-old Korean female developed multiple pruritic skin nodules on the pubic area 13 months later after diagnosis of uterine papillary serous carcinoma.
  • A biopsy of the skin lesions showed papillary serous carcinoma, compatible with her primary tumor.
  • Without clinical history, it is difficult to distinguish other types of metastatic carcinoma to the skin and primary apocrine carcinoma of the skin from metastatic uterine papillary serous carcinoma.
  • Whereas uterine papillary serous carcinoma only rarely involves the skin, this entity should be included in the differential diagnosis of papillary adenocarcinoma in the skin.
  • [MeSH-major] Cystadenocarcinoma, Papillary / secondary. Skin Neoplasms / secondary. Uterine Neoplasms / pathology

  • MedlinePlus Health Information. consumer health - Skin Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16148416.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


48. Iwenofu OH, Samie FH, Ralston J, Cheney RT, Zeitouni NC: Extramammary Paget's disease presenting as alopecia neoplastica. J Cutan Pathol; 2008 Aug;35(8):761-4
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Extramammary Paget's disease (EMPD) is a rare malignant neoplasm with a predilection for the apocrine-rich anogenital skin and less commonly for the axilla.
  • The tumor rarely occurs in non-apocrine bearing regions where it is referred to as ectopic EMPD.
  • Immunohistochemistry showed that the tumor cells stained positively for mucicarmine, periodic acid schiff, cytokeratin-7, polyclonal carcinoembryonic antigen, epithelial membrane antigen, gross cystic disease fluid protein, androgen receptor and Her-2-neu; and negatively for S-100, HMB-45, CDX-2, thyroid transcription factor-1, estrogen receptor and progesterone receptor, thus, establishing the diagnosis of ectopic EMPD.
  • [MeSH-major] Alopecia Areata / metabolism. Alopecia Areata / pathology. Biomarkers, Tumor / metabolism. Paget Disease, Extramammary / metabolism. Paget Disease, Extramammary / pathology. Skin Neoplasms / metabolism. Skin Neoplasms / pathology

  • MedlinePlus Health Information. consumer health - Skin Cancer.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [CommentIn] J Cutan Pathol. 2009 Aug;36(8):917-8 [19586507.001]
  • (PMID = 18422977.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 36
  •  go-up   go-down


49. Kurzen H, Kurokawa I, Jemec GB, Emtestam L, Sellheyer K, Giamarellos-Bourboulis EJ, Nagy I, Bechara FG, Sartorius K, Lapins J, Krahl D, Altmeyer P, Revuz J, Zouboulis CC: What causes hidradenitis suppurativa? Exp Dermatol; 2008 May;17(5):455-6; discussion 457-72
ClinicalTrials.gov. clinical trials - ClinicalTrials.gov .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Hidradenitis suppurativa (HS)--a rather common, very chronic and debilitating inflammatory skin appendage disorder with a notoriously underestimated burden of disease--has long been a playground for the high priests of nomenclature: Ask a bunch of eminent dermatologists and skin pathologists to publicly share their thoughts on what causes HS, and they will soon get entrenched in a heated debate on whether this historical term is a despicable misnomer.
  • [MeSH-major] Apocrine Glands / physiopathology. Hair Follicle / physiopathology. Hidradenitis Suppurativa / etiology. Skin / physiopathology
  • [MeSH-minor] Androgens / physiology. Female. Friction. Genetic Predisposition to Disease. Humans. Male. Risk Factors. Smoking / adverse effects. Staphylococcal Skin Infections / complications. Tumor Necrosis Factor-alpha / immunology

  • Genetic Alliance. consumer health - Hidradenitis Suppurativa.
  • MedlinePlus Health Information. consumer health - Hidradenitis Suppurativa.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18400064.001).
  • [ISSN] 1600-0625
  • [Journal-full-title] Experimental dermatology
  • [ISO-abbreviation] Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Androgens; 0 / Tumor Necrosis Factor-alpha
  •  go-up   go-down


50. De Francesco V, Frattasio A, Pillon B, Stinco G, Scott CA, Trotter D, Patrone P: Carcinosarcoma arising in a patient with multiple cylindromas. Am J Dermatopathol; 2005 Feb;27(1):21-6
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In 1997 she underwent surgical excision of the entire forehead and scalp with skin grafting.
  • The lesion was excised and histologic and immunohistochemical evaluation revealed a malignant cutaneous biphasic tumor extending into the subcutis, consisting of a major portion with the features of an adnexal carcinoma and of a minor one of atypical spindle cells.
  • Biphasic malignant skin tumors are rare and only a limited number have been described, none in association with the Brooke-Spiegler syndrome.
  • The authors discuss the morphogenesis of the folliculosebaceous-apocrine unit from which the tumors in this syndrome derive, and the pivotal role of mesenchymal cells in determining the process.
  • Since the Brooke-Spiegler syndrome is characterized by a germline mutation in the CYLD oncosuppressor gene, a biphasic tumor in this setting may represent a true carcinosarcoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Carcinoma, Skin Appendage / pathology. Carcinosarcoma / pathology. Neoplasms, Second Primary / pathology. Neoplastic Syndromes, Hereditary / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Female. Humans. Immunohistochemistry. Skin Transplantation. Treatment Outcome

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15677972.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  •  go-up   go-down


51. von Bomhard W, Goldschmidt MH, Shofer FS, Perl L, Rosenthal KL, Mauldin EA: Cutaneous neoplasms in pet rabbits: a retrospective study. Vet Pathol; 2007 Sep;44(5):579-88
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A total of 23 different tumor types and 1 tumorlike lesion were diagnosed.
  • Common nonviral epithelial tumors included trichoblastoma (59), squamous cell carcinoma (5), squamous papilloma (4), trichoepithelioma (3), and apocrine carcinoma (3).
  • Common mesenchymal tumors were lipoma (10), liposarcoma (3), myxosarcoma (9), malignant peripheral nerve sheath tumor (8), fibrosarcoma (7), and leiomyosarcoma (4).
  • One malignant melanoma (1 of 3) and one poorly differentiated round cell neoplasm recurred (1 of 1).
  • This is the first comprehensive retrospective analysis on skin neoplasia in pet rabbits.
  • [MeSH-major] Rabbits. Skin Neoplasms / veterinary
  • [MeSH-minor] Adenoma / pathology. Adenoma / veterinary. Animals. Biopsy / veterinary. Carcinoma / pathology. Carcinoma / veterinary. Female. Hamartoma / pathology. Hamartoma / veterinary. Lipoma / pathology. Lipoma / veterinary. Lymphoma / pathology. Lymphoma / veterinary. Male. Melanoma / pathology. Melanoma / veterinary. Retrospective Studies. Sarcoma / pathology. Sarcoma / veterinary. Tumor Virus Infections / veterinary

  • MedlinePlus Health Information. consumer health - Skin Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17846230.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


52. Alessi E, Venegoni L, Fanoni D, Berti E: Cytokeratin profile in basal cell carcinoma. Am J Dermatopathol; 2008 Jun;30(3):249-55
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We studied the cytokeratin (CK) profile in BCC using monoclonal antibodies against 12 CKs to further investigate the suggested origin of the tumor from follicular matrix cells or from follicular outer root sheath cells and to determine if BCC subtypes can be identified on the basis of their CK profiles.
  • Cases of pilomatricoma and samples of fetal skin served as controls to establish the CK profile in matrical cells and developing follicles during intrauterine life, that of the epidermis and cutaneous adnexa in adult life having been determined in a previous study.
  • The study suggests a tumorous differentiation toward follicular outer root sheath cells and, in most cases, also toward the glandular components of the pilosebaceous-apocrine unit.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Carcinoma, Basal Cell / metabolism. Keratins / metabolism. Skin Neoplasms / metabolism
  • [MeSH-minor] Cell Transformation, Neoplastic. Fetus. Gestational Age. Hair Diseases / metabolism. Hair Diseases / pathology. Hair Follicle / metabolism. Hair Follicle / pathology. Humans. Keratinocytes / metabolism. Keratinocytes / pathology. Pilomatrixoma / metabolism. Pilomatrixoma / pathology. Skin / chemistry. Skin / embryology

  • MedlinePlus Health Information. consumer health - Skin Cancer.
  • COS Scholar Universe. author profiles.
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18496426.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 68238-35-7 / Keratins
  •  go-up   go-down


53. Ogawa R, Akaishi S, Hyakusoku H: Differential and exclusive diagnosis of diseases that resemble keloids and hypertrophic scars. Ann Plast Surg; 2009 Jun;62(6):660-4
MedlinePlus Health Information. consumer health - Skin Conditions.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • All tumors were benign: apocrine cystadenoma, adult-onset juvenile xanthogranuloma, mixed tumor, and chronic folliculitis.
  • (1) biopsy should be conducted in anomalous cases because malignant disease may be the original or secondary problem, (2) steroid injection should be performed only after careful consideration because malignancy or infections may be present, (3) careful differential diagnosis is particularly challenging in African-Americans because skin and tumor color are often similar, and (4) the presence of bacterial or fungal infection should be investigated.
  • [MeSH-major] Cicatrix, Hypertrophic / diagnosis. Keloid / diagnosis. Skin Diseases / diagnosis

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19461281.001).
  • [ISSN] 1536-3708
  • [Journal-full-title] Annals of plastic surgery
  • [ISO-abbreviation] Ann Plast Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


54. Regauer S, Nogales FF: Vulvar trichogenic tumors: a comparative study with vulvar basal cell carcinoma. Am J Surg Pathol; 2005 Apr;29(4):479-84
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Trichogenic tumors are very rare in genital skin and often cause diagnostic problems because they are mitotically active and they share some histologic features with basal cell carcinomas (BCCs).
  • Most cysts were keratinized, but some fluid-filled cysts showed apocrine and sebaceous differentiation.
  • BCCs showed no trichogenic differentiation and lacked an organized mesenchymal tumor component.
  • The tumor stroma of BCCs was paucicellular, mucinous, or granulation tissue-like with an inflammatory infiltrate.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Neoplasms, Adnexal and Skin Appendage / pathology. Skin Neoplasms / pathology. Vulvar Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Female. Humans. Immunohistochemistry. Keratins / analysis. Middle Aged

  • MedlinePlus Health Information. consumer health - Skin Cancer.
  • MedlinePlus Health Information. consumer health - Vulvar Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15767801.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 68238-35-7 / Keratins
  •  go-up   go-down


55. Fukuda M, Hiroi M, Suzuki S, Ohmori Y, Sakashita H: Loss of CYLD might be associated with development of salivary gland tumors. Oncol Rep; 2008 Jun;19(6):1421-7
MedlinePlus Health Information. consumer health - Salivary Gland Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Molecular studies of cylindromas, which arise from the eccrine or apocrine cells of the skin, have demonstrated frequent alterations at chromosome 16q12-13, recently found to house the cylindromatosis (CYLD) gene.
  • CYLD, a tumor suppressor gene, has deubiquitinating enzyme activity and inhibits the activation of transcription factor NF-kappaB.
  • We demonstrated previously that human salivary gland tumor (SGT) cell line, HSG spontaneously expresses CYLD and also found that adenoid cystic carcinoma (ACC) arising from the hard palate was distinctly positive for CYLD, immunohistochemically.
  • [MeSH-major] Carcinoma, Adenoid Cystic / metabolism. Genes, Tumor Suppressor / physiology. Salivary Gland Neoplasms / metabolism. Tumor Suppressor Proteins / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. I-kappa B Kinase / metabolism. Male. Middle Aged. NF-kappa B / metabolism. RNA, Messenger / metabolism. RNA, Small Interfering / pharmacology. Reverse Transcriptase Polymerase Chain Reaction. Transcription Factor RelA / metabolism. Tumor Necrosis Factor-alpha / pharmacology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18497946.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / CYLD protein, human; 0 / NF-kappa B; 0 / RNA, Messenger; 0 / RNA, Small Interfering; 0 / Transcription Factor RelA; 0 / Tumor Necrosis Factor-alpha; 0 / Tumor Suppressor Proteins; EC 2.7.11.10 / I-kappa B Kinase
  •  go-up   go-down


56. Yamauchi PS, Mau N: Hidradenitis suppurativa managed with adalimumab. J Drugs Dermatol; 2009 Feb;8(2):181-3
MedlinePlus Health Information. consumer health - Hidradenitis Suppurativa.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Hidradenitis suppurativa (HS), a chronic, inflammatory, relapsing disease of the apocrine glands in the skin, commonly occurs in women aged 20 to 40 years.
  • Recent reports have demonstrated that adalimumab, a tumor necrosis factor (TNF) antagonist, may be effective in the treatment of patients with HS who have failed conventional therapy.
  • The authors describe 3 patients who experienced the resolution of skin lesions associated with HS after treatment with adalimumab.
  • [MeSH-minor] Adalimumab. Adult. Antibodies, Monoclonal, Humanized. Chronic Disease. Female. Humans. Injections, Subcutaneous. Self Administration. Tumor Necrosis Factor-alpha / antagonists & inhibitors

  • Genetic Alliance. consumer health - Hidradenitis Suppurativa.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19213236.001).
  • [ISSN] 1545-9616
  • [Journal-full-title] Journal of drugs in dermatology : JDD
  • [ISO-abbreviation] J Drugs Dermatol
  • [Language] eng
  • [Publication-type] Case Reports
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Tumor Necrosis Factor-alpha; FYS6T7F842 / Adalimumab
  •  go-up   go-down


57. Revuz J: Hidradenitis suppurativa. J Eur Acad Dermatol Venereol; 2009 Sep;23(9):985-98
MedlinePlus Health Information. consumer health - Hidradenitis Suppurativa.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Hidradenitis suppurativa is a chronic disease characterized by recurrent, painful, deep-seated, rounded nodules and abscesses of apocrine gland-bearing skin.
  • The primary event is a follicular occlusion with secondary inflammation, infection and destruction of the pilo-sebaceo-apocrine apparatus and extension to the adjacent sub-cutaneous tissue.
  • [MeSH-minor] Anti-Bacterial Agents / therapeutic use. Diagnosis, Differential. Humans. Laser Therapy. Radiotherapy. Risk Factors. Severity of Illness Index. Skin / pathology. Steroids / therapeutic use. Tumor Necrosis Factor-alpha / antagonists & inhibitors

  • Genetic Alliance. consumer health - Hidradenitis Suppurativa.
  • Genetics Home Reference. consumer health - hidradenitis suppurativa.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19682181.001).
  • [ISSN] 1468-3083
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Steroids; 0 / Tumor Necrosis Factor-alpha
  •  go-up   go-down


58. Yim YM, Yoon JW, Seo JW, Kwon H, Jung SN: Pleomorphic adenoma in the auricle. J Craniofac Surg; 2009 May;20(3):951-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Pleomorphic adenoma (PA) is a rare tumor of the skin that may arise from either the apocrine or the eccrine glands.
  • Under a clinical diagnosis of an epidermal inclusion cyst, we performed a total excision of the tumor with the skin and with direct closure.
  • These findings suggested that this tumor originated from the apocrine glands.
  • Recurrence is rare if there is complete resection of the tumor along with the surrounding capsule.
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Carrier Proteins / analysis. Cyst Fluid / chemistry. Diagnosis, Differential. Ear Diseases / diagnosis. Epidermal Cyst / diagnosis. Epithelial Cells / pathology. Female. Follow-Up Studies. Glycoproteins / analysis. Humans. Keratins / analysis. Mucin-1 / analysis

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19461339.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Carrier Proteins; 0 / Glycoproteins; 0 / Mucin-1; 0 / PIP protein, human; 68238-35-7 / Keratins
  •  go-up   go-down


59. Kazakov DV, Soukup R, Mukensnabl P, Boudova L, Michal M: Brooke-Spiegler syndrome: report of a case with combined lesions containing cylindromatous, spiradenomatous, trichoblastomatous, and sebaceous differentiation. Am J Dermatopathol; 2005 Feb;27(1):27-33
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The histopathological survey revealed a plethora of benign adnexal neoplasms showing apocrine, follicular, and sebaceous differentiation occurring independently and conjointly.
  • By far the most common composite tumor was spiradenocylindroma.
  • [MeSH-major] Carcinoma, Skin Appendage / pathology. Neoplasms, Multiple Primary / pathology. Neoplastic Syndromes, Hereditary / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adenoma, Sweat Gland / metabolism. Adenoma, Sweat Gland / pathology. Adenoma, Sweat Gland / surgery. Aged. Biomarkers, Tumor / metabolism. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Adenoid Cystic / surgery. Hair Diseases / metabolism. Hair Diseases / pathology. Hair Diseases / surgery. Hair Follicle / metabolism. Hair Follicle / pathology. Humans. Immunoenzyme Techniques. Male. Sebaceous Glands / metabolism. Sebaceous Glands / pathology. Syndrome

  • Genetic Alliance. consumer health - Brooke-Spiegler syndrome.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15677973.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  •  go-up   go-down


60. Presutti L, Alicandri-Ciufelli M, Mattioli F, Marchioni D, Costantini M: A case of syryngocystadenoma papilliferum (SCAP) involving middle ear, presenting with otomastoiditis and cerebral abscess. Auris Nasus Larynx; 2008 Sep;35(3):401-3
MedlinePlus Health Information. consumer health - Streptococcal Infections.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Syryngocystadenoma papilliferum (SCAP) is an uncommon cutaneous adnexal neoplasm of apocrine gland origin.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17870265.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  •  go-up   go-down


61. Cecchi R, Pavesi M, Bartoli L, Brunetti L, Rapicano V: Perineal extramammary Paget disease responsive to topical imiquimod. J Dtsch Dermatol Ges; 2010 Jan;8(1):38-40
Hazardous Substances Data Bank. Imiquimod .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Extramammary Paget disease (EMPD) is a rare neoplasm that arises in skin rich in apocrine glands, such as the axillae and anogenital region and usually affects the elderly.
  • In most cases, EMPD is an apocrine carcinoma in situ, but it can be associated with internal malignancy spreading to overlying skin.
  • Because of the location and extent of the tumor, any surgical approach would have been problematic.
  • [MeSH-major] Aminoquinolines / administration & dosage. Paget Disease, Extramammary / drug therapy. Skin Neoplasms / drug therapy

  • Genetic Alliance. consumer health - Paget Disease.
  • Genetic Alliance. consumer health - Paget disease, extramammary.
  • MedlinePlus Health Information. consumer health - Skin Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20096058.001).
  • [ISSN] 1610-0387
  • [Journal-full-title] Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
  • [ISO-abbreviation] J Dtsch Dermatol Ges
  • [Language] eng; ger
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Aminoquinolines; 0 / Antineoplastic Agents; 99011-02-6 / imiquimod
  •  go-up   go-down


62. Tirumalae R, Böer A: Calcification and ossification in eccrine mixed tumors: underrecognized feature and diagnostic pitfall. Am J Dermatopathol; 2009 Dec;31(8):772-7
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Eccrine mixed tumors of the skin are rare adnexal neoplasms, and their morphological spectrum is not well established.
  • METHODS: Among 70, 000 skin biopsies, 5 were diagnosed as eccrine mixed tumors.
  • The stroma was mucinous and chondroid, calcification ranging from little to extensive with bone formation in 3 examples giving the impression of a chondroid or osseous neoplasm.
  • CONCLUSIONS: Eccrine mixed tumors are distinctive tumors that should not be lumped together with their apocrine counterparts.
  • [MeSH-major] Eccrine Glands / pathology. Neoplasms, Adnexal and Skin Appendage / pathology. Neoplasms, Complex and Mixed / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Calcinosis. Humans. Immunohistochemistry. Middle Aged

  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19730221.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  •  go-up   go-down


63. Volmar KE, Cummings TJ, Wang WH, Creager AJ, Tyler DS, Xie HB: Clear cell hidradenoma: a mimic of metastatic clear cell tumors. Arch Pathol Lab Med; 2005 May;129(5):e113-6
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Clear cell hidradenoma is a benign skin appendage tumor that may mimic conventional-type renal cell carcinoma.
  • Histologically, clear cell hidradenoma contains small ductular lumens, focal apocrine and squamoid change, and a less prominent vascular pattern than renal cell carcinoma.
  • Knowing the cytologic features of primary skin adnexal neoplasms helps distinguish them from cutaneous metastases, which are more commonly referred for fine-needle aspiration biopsy evaluation.
  • [MeSH-minor] Axilla. Biomarkers, Tumor / analysis. Diagnosis, Differential. Humans. Immunohistochemistry. Lymph Nodes / pathology. Lymph Nodes / surgery. Male. Middle Aged. Mitotic Index. Neoplasm Metastasis / diagnosis. Treatment Outcome

  • MedlinePlus Health Information. consumer health - Kidney Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15859654.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  •  go-up   go-down


64. Barré C, Lorenzato M, Bourdat B, Quéreux C, Durlach A: [Vulvar invasive squamous cell carcinoma and hidradenoma papilliferum. Case report]. Gynecol Obstet Fertil; 2007 Sep;35(9):776-9
MedlinePlus Health Information. consumer health - Vulvar Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We report a case of a vulvar invasive squamous cell carcinoma associated to a benign tumor with apocrine differenciation, the hidradenoma papilliferum, infiltrated by the carcinoma.
  • [MeSH-minor] Aged. Biopsy. Female. Humans. Neoplasm Invasiveness

  • Genetic Alliance. consumer health - Carcinoma, Squamous Cell.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17766164.001).
  • [ISSN] 1297-9589
  • [Journal-full-title] Gynécologie, obstétrique & fertilité
  • [ISO-abbreviation] Gynecol Obstet Fertil
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  •  go-up   go-down


65. Knoedler D, Susnik B, Gonyo MB, Osipov V: Giant apocrine hidradenoma of the breast. Breast J; 2007 Jan-Feb;13(1):91-3
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant apocrine hidradenoma of the breast.
  • We report a case of a 26-year-old woman with an 8.0-cm tumor of the left breast.
  • The tumor was clinically and radiologically suspicious for malignancy.
  • The pathologic evaluation of the core biopsy and the subsequent excision specimen revealed a benign sclerosing, cystic, and papillary adnexal tumor with apocrine and clear cell morphology.
  • The final diagnosis was apocrine hidradenoma.

  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17214802.001).
  • [ISSN] 1075-122X
  • [Journal-full-title] The breast journal
  • [ISO-abbreviation] Breast J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


66. Villalón G, Monteagudo C, Martín JM, Ramón D, Alonso V, Jordá E: [Chondroid syringoma: a clinical and histological review of eight cases]. Actas Dermosifiliogr; 2006 Nov;97(9):573-7
Genetic Alliance. consumer health - Syringoma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • INTRODUCTION: Chondroid syringoma is a rare skin tumor that presents as a slow growing, indolent lesion, that is more frequent in male adults and is usually benign.
  • It can be classified as eccrine and apocrine according to its pathological characteristics.
  • Five of the eight cases were apocrine, one of them with follicular and sebaceous differentiation.
  • DISCUSSION: The chondroid syringoma is usually a small-sized skin tumor, frequently on the head and neck.
  • As a general rule, it is a benign tumor.
  • Some authors have proposed the term of atypical mixed tumor of the skin for those chondroid syringomas with histological traits of malignancy but without evidence of metastasis.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17173760.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
  •  go-up   go-down


67. Choi YD, Cho NH, Park YS, Cho SH, Lee G, Park K: Lymphovascular and marginal invasion as useful prognostic indicators and the role of c-erbB-2 in patients with male extramammary Paget's disease: a study of 31 patients. J Urol; 2005 Aug;174(2):561-5
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: Extramammary Paget's disease (EMPD) is a rare intraepithelial neoplasm arising in skin that bears apocrine glands.
  • Dermal invasion depth, tumor margin status, adnexal invasion and lymphovascular invasion were determined from the hematoxylin and eosin stained slides of each case.
  • [MeSH-minor] Aged. Aged, 80 and over. Humans. Immunohistochemistry. In Situ Hybridization. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Recurrence, Local / pathology. Prognosis. Scrotum

  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [ErratumIn] J Urol. 2005 Oct;174(4 Pt 1):1505. Park, Kyoungmee [added]
  • (PMID = 16006892.001).
  • [ISSN] 0022-5347
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / Receptor, ErbB-2
  •  go-up   go-down


68. Ishida M, Kojima F, Kushima R, Kakutani A, Okabe H: [Case of clear cell hidradenoma with mucinous metaplasia in the forehead--immunohistochemical analysis of the mucin]. Rinsho Byori; 2006 Aug;54(8):781-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Mucinous metaplasia rarely develops in the non-neoplastic skin or its appendages, and almost exclusively confined to the genitalia, palms and soles.
  • Our immunohistochemical analysis revealed MUC5AC in the mucinous metaplastic cells of this tumor as in the extramammary Paget's disease, and expression of this gastric foveolar epithelial mucin core protein in these two neoplastic conditions seem to related to their common apocrine origin.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16989395.001).
  • [ISSN] 0047-1860
  • [Journal-full-title] Rinsho byori. The Japanese journal of clinical pathology
  • [ISO-abbreviation] Rinsho Byori
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / MUC5AC protein, human; 0 / Mucin 5AC; 0 / Mucins
  •  go-up   go-down


69. Kavand S, Cassarino DS: "Squamoid eccrine ductal carcinoma": an unusual low-grade case with follicular differentiation. Are these tumors squamoid variants of microcystic adnexal carcinoma? Am J Dermatopathol; 2009 Dec;31(8):849-52
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Squamoid eccrine ductal carcinoma is a rare primary cutaneous tumor exhibiting both squamous and adnexal ductal differentiation.
  • We report an additional case of a slow-growing tumor, occurring on the great toe of a 61-year-old woman, which was unusual as it showed follicular differentiation in addition to squamoid and ductal areas.
  • The lesional cells were positive for cytokeratins 7 and 17, carcinoembryonic antigen (which highlighted the ductal structures), and p63 (favoring a primary cutaneous tumor) and showed low levels of staining with Ki-67 and p53, consistent with a low-grade tumor.
  • We postulate that these tumors may be closely related to microcystic adnexal carcinoma and similarly show differentiation along both follicular and ductal lines, likely indicating folliculosebaceous-apocrine, rather than eccrine, origin or differentiation.
  • [MeSH-major] Carcinoma, Skin Appendage / pathology. Carcinoma, Squamous Cell / pathology. Eccrine Glands / pathology. Hair Follicle / pathology. Skin Neoplasms / pathology

  • Genetic Alliance. consumer health - Microcystic adnexal carcinoma.
  • MedlinePlus Health Information. consumer health - Skin Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19786851.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


70. Barbarino S, McCormick SA, Lauer SA, Milman T: Syringocystadenoma papilliferum of the eyelid. Ophthal Plast Reconstr Surg; 2009 May-Jun;25(3):185-8
Genetic Alliance. consumer health - Syringocystadenoma papilliferum.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: To describe 6 patients with syringocystadenoma papilliferum of the eyelid and to review the literature regarding this rare eyelid tumor.
  • The PubMed database was searched for reported cases of syringocystadenoma papilliferum of the eyelid (keywords: syringocystadenoma, eyelid, apocrine, eccrine).
  • Nine lesions (64%) were associated with apocrine, eccrine, or sebaceous tumors or malformations.
  • None of the lesions was associated with a malignant neoplasm.
  • CONCLUSIONS: Syringocystadenoma papilliferum can rarely affect eyelid skin.
  • The evidence suggests that this tumor should be managed with conservative complete excision.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19454927.001).
  • [ISSN] 1537-2677
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 12
  •  go-up   go-down


71. Shan SJ, Zhang N, Geng SL, Zhou Z, Chen X, Nie T, Guo Z, Li C, Liu Q, Guo Y, Wei H, Chen HD: Expression of survivin and human telomerase reverse transcriptase in extramammary Paget's disease. J Cutan Pathol; 2010 Jun;37(6):635-40
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Extramammary Paget's disease (EMPD) is a rare neoplasm of apocrine gland-bearing skin.
  • [MeSH-major] Microtubule-Associated Proteins / metabolism. Paget Disease, Extramammary / metabolism. Skin / metabolism. Skin Neoplasms / metabolism. Telomerase / metabolism

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19788441.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / BIRC5 protein, human; 0 / Inhibitor of Apoptosis Proteins; 0 / Microtubule-Associated Proteins; EC 2.7.7.49 / Telomerase
  •  go-up   go-down


72. Fernandez-Flores A, Pol A, Juanes F, Crespo LG: Immunohistochemical phenotype of cutaneous cribriform carcinoma with a panel of 15 antibodies. Med Mol Morphol; 2007 Dec;40(4):212-7
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Owing to the cribriform pattern of the tumor, we also looked for a metastasis from other sites, mainly breast, vulva, and salivary glands, but all these were clinically excluded.
  • The tumor was negative for iron stain.
  • In spite of these characteristics, which are, for some authors, indicative of an apocrine phenotype, the immunohistochemical study revealed some differences with the profile that has been described in cases of apocrine adenocarcinoma.
  • The tumor did not express GCDFP-15 or CD 15.
  • Other markers expressed by the tumor were EMA, ER, c-erbB-2, p53, and S-100.
  • [MeSH-major] Adenocarcinoma / immunology. Adenocarcinoma / pathology. Antibodies, Neoplasm / immunology. Skin Neoplasms / immunology. Skin Neoplasms / pathology

  • MedlinePlus Health Information. consumer health - Skin Cancer.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] J Clin Pathol. 2005 Jul;58(7):757-61 [15976347.001]
  • [Cites] Am J Clin Pathol. 1998 Jan;109(1):75-84 [9426521.001]
  • [Cites] Pathol Annu. 1987;22 Pt 1:83-124 [3033589.001]
  • [Cites] J Clin Pathol. 2005 Feb;58(2):217-9 [15677547.001]
  • [Cites] Acta Pathol Jpn. 1991 Dec;41(12):927-32 [1785351.001]
  • [Cites] J Cutan Pathol. 2005 Sep;32(8):577-80 [16115058.001]
  • [Cites] Cancer. 1993 Jan 15;71(2):375-81 [7678545.001]
  • [Cites] J Vet Diagn Invest. 2005 Jul;17(4):389-92 [16131002.001]
  • [Cites] Am J Surg Pathol. 1994 Aug;18(8):832-6 [8037297.001]
  • [Cites] Am J Dermatopathol. 1995 Jun;17(3):249-55 [8599433.001]
  • [Cites] Am J Clin Pathol. 1999 May;111(5):709 [10230363.001]
  • [Cites] Arch Dermatol. 1978 Feb;114(2):198-203 [629545.001]
  • [Cites] Dermatology. 1999;199(4):332-7 [10640844.001]
  • [Cites] J Cutan Pathol. 1999 May;26(5):232-41 [10408348.001]
  • (PMID = 18085381.001).
  • [ISSN] 1860-1480
  • [Journal-full-title] Medical molecular morphology
  • [ISO-abbreviation] Med Mol Morphol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antibodies, Neoplasm
  •  go-up   go-down


73. Kazakov DV, Mikyskova I, Kutzner H, Simpson RH, Hes O, Mukensnabl P, Bouda J, Zamecnik M, Kinkor Z, Michal M: Hidradenoma papilliferum with oxyphilic metaplasia: a clinicopathological study of 18 cases, including detection of human papillomavirus. Am J Dermatopathol; 2005 Apr;27(2):102-10
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Each presented clinically with a small, solitary tumor in the anogenital region.
  • This finding could be likened to apocrine metaplasia, a term used in breast pathology.
  • Other histopathological findings observed in this series, analogous to benign breast disease, included sclerosing adenosis-like changes, atypical apocrine adenosis-like changes, changes corresponding to usual ductal epithelial hyperplasia, epitheliomatosis with a streaming growth pattern, lamprocyte-like changes, clear cell change of the myoepithelium, foamy histiocyte reaction, and stromal fibrosis.
  • Oxyphilic metaplasia, areas with solid growth, and changes simulating atypical apocrine adenosis are rare and poorly recognized in hidradenoma papilliferum and may cause diagnostic difficulties; in our cases several submitting pathologists suspected malignancy.
  • The exact role of the HPV in etiology and pathogenesis of this neoplasm has yet to be determined.
  • [MeSH-major] Adnexal Diseases / pathology. Metaplasia / pathology. Skin Neoplasms / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15798433.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


74. Chaudhry IH, Zembowicz A: Adnexal clear cell carcinoma with comedonecrosis: clinicopathologic analysis of 12 cases. Arch Pathol Lab Med; 2007 Nov;131(11):1655-64
MedlinePlus Health Information. consumer health - Acne.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The periphery of the tumor nests was formed by squamoid cells merging with centrally located clear cell areas containing foci of comedonecrosis.
  • No ductal, cuticular, or apocrine differentiation was seen.
  • CONCLUSIONS: Adnexal clear cell carcinoma with comedonecrosis appears to be a distinctive adnexal neoplasm that has to be distinguished from more indolent squamous cell and tricholemmal carcinomas.
  • [MeSH-major] Acne Vulgaris / pathology. Carcinoma, Squamous Cell / pathology. Neoplasms, Adnexal and Skin Appendage / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [CommentIn] Arch Pathol Lab Med. 2011 May;135(5):532; author reply 533 [21526948.001]
  • (PMID = 17979483.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen; 0 / Mucin-1
  •  go-up   go-down


75. Sawada Y, Bito T, Kabashima R, Yoshiki R, Hino R, Nakamura M, Shiraishi M, Tokura Y: Ectopic extramammary Paget's disease: case report and literature review. Acta Derm Venereol; 2010 Sep;90(5):502-5
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Extramammary Paget's disease that occurs in non-apocrine-bearing regions is referred to as ectopic and has been rarely reported.
  • Like-wise, some germinative apocrine-differentiating cells might exist on the trunk preferentially in Asians.
  • [MeSH-major] Paget Disease, Extramammary / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Asian Continental Ancestry Group. Back. Biomarkers, Tumor / analysis. Biopsy. Humans. Immunohistochemistry. Male. Middle Aged. Skin / pathology. Treatment Outcome

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20814627.001).
  • [ISSN] 1651-2057
  • [Journal-full-title] Acta dermato-venereologica
  • [ISO-abbreviation] Acta Derm. Venereol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Sweden
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  •  go-up   go-down


76. Kazakov DV, Sima R, Vanecek T, Kutzner H, Palmedo G, Kacerovska D, Grossmann P, Michal M: Mutations in exon 3 of the CTNNB1 gene (beta-catenin gene) in cutaneous adnexal tumors. Am J Dermatopathol; 2009 May;31(3):248-55
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Except for pilomatricoma and pilomatrical carcinoma, only a handful of other cutaneous adnexal tumor types have been studied.
  • DNA was extracted from 86 lesions including 17 proliferating tricholemmal and trichilemmal tumors, 15 trichoblastomas, 7 trichoadenomas, 4 pilomatricomas, 1 pilomatrical carcinoma, 4 basal cell carcinomas (BCCs) with shadow cells, 2 trichofolliculomas, 3 BCCs with sebaceous differentiation, 9 sebaceous adenomas, 6 sebaceomas, 14 sebaceous carcinomas (both ocular and extraocular forms), 2 gigantic horns, and 2 apocrine mixed tumors with shadow cells and subjected to polymerase chain reaction with newly designed primers encompassing glycogen synthase kinase-3beta phosphorylation sites of the CTNNB1 gene.
  • [MeSH-major] Exons. Mutation. Neoplasms, Adnexal and Skin Appendage / genetics. Skin Neoplasms / genetics. beta Catenin / genetics

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19384065.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CTNNB1 protein, human; 0 / beta Catenin
  •  go-up   go-down


77. Tsunemi Y, Saeki H, Kikuchi K, Tamaki K, Sato S: Extramammary Paget's disease with intracytoplasmic lumen formation. J Dermatol; 2009 Dec;36(12):649-53
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Extramammary Paget's disease (EMPD) is regarded as a malignancy most likely derived from or differentiated into apocrine sweat duct and gland.
  • The tumor cells in EMPD usually have abundant pale cytoplasm and large pleomorphic nuclei.
  • We present a case with EMPD where the tumor included many signet ring cells, cells with intracytoplasmic lumen formation and glandular formation.
  • This case is interesting in that the tumor included many cells with intracytoplasmic lumen formation.
  • Signet ring cells and glandular formation support the traditional speculation that EMPD is derived from apocrine sweat gland and intracytoplasmic lumen formation may mimic the intrafollicular apocrine duct.
  • [MeSH-major] Paget Disease, Extramammary / pathology. Skin Neoplasms / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19958450.001).
  • [ISSN] 1346-8138
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  •  go-up   go-down


78. Gündüz K, Demirel S, Heper AO, Günalp I: A rare case of atypical chondroid syringoma of the lower eyelid and review of the literature. Surv Ophthalmol; 2006 May-Jun;51(3):280-5
Genetic Alliance. consumer health - Syringoma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We performed excisional biopsy of the lesion and lateral advancement skin flap for reconstruction of the skin defect.
  • Chondroid syringoma is a rare skin tumor that occurs, very rarely, in the eyelids, especially the lower eyelid.
  • Chondroid syringomas are classified as two types, the apocrine type characterized by tubular and cystic branching lumina lined by two layers of epithelial cells, and the eccrine type, which has small tubular lumina lined by a single layer of epithelial cells.
  • The tumor can have benign, atypical, and malignant variants.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16644368.001).
  • [ISSN] 0039-6257
  • [Journal-full-title] Survey of ophthalmology
  • [ISO-abbreviation] Surv Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


79. Daniel F, Mahmoudi A, de Parades V, Fléjou JF, Atienza P: An uncommon perianal nodule: hidradenoma papilliferum. Gastroenterol Clin Biol; 2007 Feb;31(2):166-8
MedlinePlus Health Information. consumer health - Anal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Hidradenoma papilliferum is a rare, benign, cystic, papillary apocrine gland tumor that occurs almost exclusively in women in the skin of the anogenital region.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17347625.001).
  • [ISSN] 0399-8320
  • [Journal-full-title] Gastroentérologie clinique et biologique
  • [ISO-abbreviation] Gastroenterol. Clin. Biol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
  •  go-up   go-down


80. Battistella M, Peltre B, Cribier B: Composite tumors associating trichoblastoma and benign epidermal/follicular neoplasm: another proof of the follicular nature of inverted follicular keratosis. J Cutan Pathol; 2010 Oct;37(10):1057-63
MedlinePlus Health Information. consumer health - Skin Conditions.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Composite tumors associating trichoblastoma and benign epidermal/follicular neoplasm: another proof of the follicular nature of inverted follicular keratosis.
  • Only one case of sporadic TB in a composite tumor has been reported, arising in an apocrine poroma.
  • We report the association of TB and benign epidermal/follicular neoplasm in six patients.
  • It was often positive in the associated neoplasm.
  • CONCLUSION: TB can be associated with benign epidermal/follicular neoplasm in composite tumors.
  • Composite tumors associating trichoblastoma and benign epidermal/follicular neoplasm: another proof of the follicular nature of inverted follicular keratosis.
  • [MeSH-major] Keratosis, Seborrheic / complications. Neoplasms, Multiple Primary / pathology. Skin Diseases / complications. Skin Neoplasms / complications

  • MedlinePlus Health Information. consumer health - Skin Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19615018.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  •  go-up   go-down


81. Miyamoto T, Adachi K, Fujishima M: Axillary apocrine carcinoma with Paget's disease and apocrine naevus. Clin Exp Dermatol; 2009 Jul;34(5):e110-3
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Axillary apocrine carcinoma with Paget's disease and apocrine naevus.
  • Apocrine carcinoma is a rare malignant sweat-gland neoplasm with apocrine differentiation.
  • There have been some reported cases of apocrine carcinoma with apocrine naevus.
  • The resected specimen showed apocrine adenocarcinoma with extramammary Paget's disease and apocrine naevus.
  • On resection of this enlarging right axilla, an apocrine naevus was found.
  • [MeSH-major] Adenocarcinoma / diagnosis. Neoplasms, Multiple Primary / diagnosis. Nevus / diagnosis. Paget Disease, Extramammary / diagnosis. Skin Neoplasms / diagnosis. Sweat Gland Neoplasms / diagnosis
  • [MeSH-minor] Aged. Apocrine Glands. Axilla. Humans. Male. Positron-Emission Tomography. Precancerous Conditions / diagnosis. Tomography, X-Ray Computed

  • MedlinePlus Health Information. consumer health - Birthmarks.
  • MedlinePlus Health Information. consumer health - Moles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19438526.001).
  • [ISSN] 1365-2230
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  •  go-up   go-down


82. Kumar B: Chondroid syringoma diagnosed by fine needle aspiration cytology. Diagn Cytopathol; 2010 Jan;38(1):38-40
MedlinePlus Health Information. consumer health - Salivary Gland Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Chondroid syringoma is a rare benign skin adnexal tumor of eccrine/apocrine origin affecting commonly the head and neck region.
  • It used to be previously called as mixed tumor of skin because of the presence of both the epithelial and mesenchymal components.
  • Overlying skin was normal, and the swelling was fixed to the skin but freely mobile over underlying structure.

  • Genetic Alliance. consumer health - Syringoma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • (PMID = 19693940.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


83. Angulo J, Jaqueti G, Kutzner H, Requena L: Squamous cell apocrine hidradenoma. J Cutan Pathol; 2007 Oct;34(10):801-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Squamous cell apocrine hidradenoma.
  • Apocrine hidradenoma is a benign adnexal neoplasm with apocrine differentiation.
  • The neoplasm is composed of four different types of epithelial cells, including pale or clear cells, polygonal cells, mucinous cells and squamous cells, with variable proportions of them from case to case.
  • In most examples of this neoplasm, clear or the polygonal cells are predominant, whereas the other types of neoplastic cells are less abundant.
  • We report two cases of apocrine hidradenoma mostly composed of squamous cells.
  • The rare cases described in this report are exceptional because most of the neoplastic cells showed squamous appearance and for that reason we think that squamous cell apocrine hidradenoma is the most appropriate name for these neoplasms.
  • [MeSH-minor] Aged. Apocrine Glands / pathology. Female. Humans. Male. Middle Aged. Treatment Outcome

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17880588.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  •  go-up   go-down


84. Grin A, Colgan T, Laframboise S, Shaw P, Ghazarian D: "Pagetoid" eccrine carcinoma of the vulva: report of an unusual case with review of the literature. J Low Genit Tract Dis; 2008 Apr;12(2):134-9
MedlinePlus Health Information. consumer health - Vulvar Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Sweat gland carcinoma of the vulva is rare and may be classified as being of eccrine, apocrine, or mixed origin.
  • Most reported cases of vulvar sweat gland carcinomas associated with extramammary Paget disease describe a tumor of apocrine origin.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18369309.001).
  • [ISSN] 1526-0976
  • [Journal-full-title] Journal of lower genital tract disease
  • [ISO-abbreviation] J Low Genit Tract Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


85. Misago N, Narisawa Y: Lipomatous apocrine mixed tumor of the skin associated with chondroid and ossiferous stroma. J Dermatol; 2006 May;33(5):380-2
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Lipomatous apocrine mixed tumor of the skin associated with chondroid and ossiferous stroma.
  • [MeSH-major] Neoplasms, Multiple Primary / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adipose Tissue / pathology. Aged. Apocrine Glands / pathology. Cheek. Diagnosis, Differential. Female. Humans

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16700676.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Japan
  •  go-up   go-down


86. Kazikdas KC, Onal K, Ekinci N: Pathology quiz case 1: Apocrine mixed tumor of the skin. Arch Otolaryngol Head Neck Surg; 2007 Feb;133(2):198, 200
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pathology quiz case 1: Apocrine mixed tumor of the skin.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Apocrine Glands / pathology. Skin Neoplasms / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17309993.001).
  • [ISSN] 0886-4470
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


87. Fernandez-Flores A: Podoplanin immunostaining in cutaneous apocrine carcinoma and in cutaneous metastasis from the breast. Appl Immunohistochem Mol Morphol; 2010 Dec;18(6):573-4
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Podoplanin immunostaining in cutaneous apocrine carcinoma and in cutaneous metastasis from the breast.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20697264.001).
  • [ISSN] 1533-4058
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies; 0 / Biomarkers, Tumor; 0 / Mammaglobin A; 0 / Membrane Glycoproteins; 0 / Neoplasm Proteins; 0 / PDPN protein, human; 0 / SCGB2A2 protein, human; 9060-09-7 / Uteroglobin
  •  go-up   go-down


88. Fernandez-Flores A: Primary cutaneous apocrine carcinoma versus metastasis, a plea to the dermatopathology community. Am J Dermatopathol; 2010 Dec;32(8):853-4
MedlinePlus Health Information. consumer health - Breast Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary cutaneous apocrine carcinoma versus metastasis, a plea to the dermatopathology community.
  • [MeSH-major] Apocrine Glands / pathology. Breast Neoplasms / pathology. Neoplasms, Adnexal and Skin Appendage / pathology. Neoplasms, Second Primary
  • [MeSH-minor] Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Predictive Value of Tests

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [CommentOn] Am J Dermatopathol. 2009 May;31(3):278-81 [19384070.001]
  • (PMID = 20431390.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  •  go-up   go-down


89. Tanese K, Wakabayashi A, Suzuki T, Miyakawa S: Immunoexpression of human epidermal growth factor receptor-2 in apocrine carcinoma arising in naevus sebaceous, case report. J Eur Acad Dermatol Venereol; 2010 Mar;24(3):360-2
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunoexpression of human epidermal growth factor receptor-2 in apocrine carcinoma arising in naevus sebaceous, case report.
  • [MeSH-major] Carcinoma / immunology. Neoplasms, Multiple Primary / immunology. Nevus, Sebaceous of Jadassohn / immunology. Receptor, ErbB-2 / biosynthesis. Skin Neoplasms / immunology. Sweat Gland Neoplasms / immunology
  • [MeSH-minor] Aged. Apocrine Glands. Biomarkers, Tumor / biosynthesis. Biomarkers, Tumor / immunology. Biopsy. Humans. Immunohistochemistry. Male

  • MedlinePlus Health Information. consumer health - Skin Cancer.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19703100.001).
  • [ISSN] 1468-3083
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.10.1 / ERBB2 protein, human; EC 2.7.10.1 / Receptor, ErbB-2
  •  go-up   go-down






Advertisement