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1. Zheng F, Li GQ, Bian YJ: [Effects of Chinese medicine internal-external combined therapy in treating chronic obstructive pulmonary disease in the stable period]. Zhongguo Zhong Xi Yi Jie He Za Zhi; 2010 Apr;30(4):369-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: One hundred and seventy-eight COPD patients were randomly assigned to two groups, the control group was treated with Atrovent Metered Dose Inhalation, oral taking Mucosolvan and Bailing Capsule, and acupoint sticking with dummy plaster; the treatment group was treated with ipratropium bromide aerosol, ambroxol hydrochloride, Chinese recipe prescribed according to syndrome differentiation, and combined with acupoint sticking with Xiaochuan Plaster applied in winters and summers (3 times in a season).
  • Changes of the Chinese medicine syndrome scores, quality of life (QOL), and the pulmonary function in patients before and after treatment were observed.
  • RESULTS: Scores of Chinese medicine syndrome and QOL in the treatment group were significantly improved after treatment with the effect better than those in the control group (P < 0.05), but the change of the pulmonary function was insignificant (P > 0.05).

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  • (PMID = 20669671.001).
  • [ISSN] 1003-5370
  • [Journal-full-title] Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine
  • [ISO-abbreviation] Zhongguo Zhong Xi Yi Jie He Za Zhi
  • [Language] CHI
  • [Publication-type] English Abstract; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] China
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2. Xue M, Chen KJ, Yin HJ: [Relationship between polymorphism of platelet membrane glycoprotein IIIa and coronary heart disease with blood-stasis syndrome in Chinese Han population]. Zhong Xi Yi Jie He Xue Bao; 2009 Apr;7(4):325-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Relationship between polymorphism of platelet membrane glycoprotein IIIa and coronary heart disease with blood-stasis syndrome in Chinese Han population].
  • OBJECTIVE: To investigate the genotype distributions of PLA1/PLA2 polymorphism in Chinese Han population from Beijing and Hebei Province and to study the correlation between the platelet membrane glycoprotein IIIa polymorphism and coronary heart disease (CHD) or CHD with blood-stasis syndrome.
  • METHODS: A total of 110 CHD patients with blood-stasis syndrome and 102 CHD patients with non-blood stasis syndrome were enrolled in the case-control study.
  • Syndrome differentiation in traditional Chinese medicine was performed in all of the patients.
  • RESULTS: The locus typing of PLA1/PLA2 gene polymorphism was exclusively PLA1/PLA1 (TT) in healthy people, CHD patients and CHD patients with blood-stasis syndrome, while GPIIIa PLA1/PLA2 (TC) and PLA2/PLA2 (CC) were not found in all the selected objects.
  • CONCLUSION: The PLA1/PLA2 polymorphism of membrane glycoprotein IIIa is not a risk factor for CHD patients or CHD patients with blood-stasis syndrome in Chinese Han population, and the related genes may be some other gene polymorphisms.

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  • (PMID = 19361361.001).
  • [ISSN] 1672-1977
  • [Journal-full-title] Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
  • [ISO-abbreviation] Zhong Xi Yi Jie He Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Integrin beta3
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3. Bi KH, Jiang GS: Relationship between cytokines and leukocytosis in patients with APL induced by all-trans retinoic acid or arsenic trioxide. Cell Mol Immunol; 2006 Dec;3(6):421-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Relationship between cytokines and leukocytosis in patients with APL induced by all-trans retinoic acid or arsenic trioxide.
  • Leukocytosis or hyperleukocytosis occurs during ATRA or arsenic trioxide differentiation therapy, which is related to the RA syndrome.
  • The same trend of classification of BM was observed in most of the patients with APL to whom leukocytosis happened.
  • [MeSH-major] Antineoplastic Agents / pharmacology. Arsenicals / pharmacology. Cytokines / physiology. Leukemia, Promyelocytic, Acute / drug therapy. Leukemia, Promyelocytic, Acute / metabolism. Leukocytosis / chemically induced. Oxides / pharmacology. Tretinoin / physiology

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  • (PMID = 17257495.001).
  • [ISSN] 1672-7681
  • [Journal-full-title] Cellular & molecular immunology
  • [ISO-abbreviation] Cell. Mol. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Arsenicals; 0 / Cytokines; 0 / Oxides; 5688UTC01R / Tretinoin; S7V92P67HO / arsenic trioxide
  • [Number-of-references] 61
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4. Wang GL, Xuan YB, Cheng JL, Wen YL, Li JD, He PR: [Summarization of professor He Pu-ren's channel syndrome differentiation for treatment of complicated and difficult diseases]. Zhongguo Zhen Jiu; 2007 Jul;27(7):517-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Summarization of professor He Pu-ren's channel syndrome differentiation for treatment of complicated and difficult diseases].
  • Channel syndrome differentiation is a more commonly-used syndrome differentiation method of Professor HE Pu-ren clinically, which includes the 3 aspects: differentiation of diseases and syndromes on the channel parts along the body surface; differentiation of diseases and syndromes of the internal organs connected with the channels; differentiation of qi and blood of the channels.
  • According to results of the channel syndrome differentiation, with flexible application of the HE's Santong methods and selection of corresponding treatment program, many complicated and difficult diseases are cured.
  • [MeSH-minor] Diagnosis, Differential. Humans

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  • (PMID = 17722833.001).
  • [ISSN] 0255-2930
  • [Journal-full-title] Zhongguo zhen jiu = Chinese acupuncture & moxibustion
  • [ISO-abbreviation] Zhongguo Zhen Jiu
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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5. Li Y, Li S, Lu AP: [Comparative analysis via data mining on the clinical features of Western medicine and Chinese medicine in diagnosing rheumatoid arthritis]. Zhongguo Zhong Xi Yi Jie He Za Zhi; 2006 Nov;26(11):988-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: A total of 85 clinical RA related messages were enacted and classified into 5 sets as pathological locations, quantitative diagnosis, symptomatic descriptions, general status and environment factors.
  • The respective frequency of their presence in the TCM or WM data sets for RA diagnosis collected from MEDLINE and China National Knowledge Infrastructure (CNKI) were analyzed statistically by Chi-square test, and the relationship of some TCM diagnostic factors/conditions with the RA related biological factors was analyzed by co-occurrence-based literature approach of mining.
  • Compared with that of WM, TCM diagnosis on RA paid more attention to environmental factors and symptomatic descriptions, which showed definite association with the cytokines and neuro-endocrine factors in RA.
  • CONCLUSION: Examination of environmental factors and symptomatic descriptions for RA diagnosis is one of the important characteristics of TCM treatment in accordance to syndrome differentiation, it has its potential biologic basis.
  • A novel approach is proposed for exploring the characteristics of TCM in diagnosis and observation.

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  • (PMID = 17186727.001).
  • [ISSN] 1003-5370
  • [Journal-full-title] Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine
  • [ISO-abbreviation] Zhongguo Zhong Xi Yi Jie He Za Zhi
  • [Language] CHI
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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6. La Fianza A, Bonfichi M, Gorone MS, Gallotti A, Torretta L: Unusual abdominal findings of all-trans-retinoic acid syndrome: role of diagnostic imaging. Clin Imaging; 2007 Jul-Aug;31(4):276-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Unusual abdominal findings of all-trans-retinoic acid syndrome: role of diagnostic imaging.
  • The standard therapy for patients affected by acute promyelocytic leukemia is based on all-trans-retinoic acid (ATRA), whose rare complication is a syndrome known as retinoic acid syndrome.
  • We describe for the first time the computed tomography findings of a case of ATRA syndrome with typical pulmonary findings, along with the involvement of the upper abdomen organs (liver and spleen) as a further complication of the pathology.
  • [MeSH-major] Abdomen / pathology. Abdomen / ultrasonography. Leukemia, Promyelocytic, Acute / complications. Leukemia, Promyelocytic, Acute / drug therapy. Tretinoin / adverse effects. Tretinoin / therapeutic use
  • [MeSH-minor] Acute Disease. Adult. Fatal Outcome. Humans. Male. Syndrome

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  • (PMID = 17599624.001).
  • [ISSN] 0899-7071
  • [Journal-full-title] Clinical imaging
  • [ISO-abbreviation] Clin Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 5688UTC01R / Tretinoin
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7. Gu ZY, Luo F: [Study on acupuncture for treatment of oculomotor paralysis according to syndrome differentiation of meridians]. Zhongguo Zhen Jiu; 2010 Feb;30(2):129-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Study on acupuncture for treatment of oculomotor paralysis according to syndrome differentiation of meridians].
  • The authors compared and analyzed the correlated meridians in Internal Classic and Study on the Eight Extra-Channels and Vessels by clinical observation on acupuncture for treatment of oculomotor paralysis and reorganization research on ancient related literature, and course of meridians and collaterals, manifestations of disease and function were used as indexes.
  • [MeSH-major] Acupuncture Therapy / methods. Meridians. Ophthalmoplegia / diagnosis. Ophthalmoplegia / therapy
  • [MeSH-minor] Diagnosis, Differential. Humans

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  • (PMID = 20214071.001).
  • [ISSN] 0255-2930
  • [Journal-full-title] Zhongguo zhen jiu = Chinese acupuncture & moxibustion
  • [ISO-abbreviation] Zhongguo Zhen Jiu
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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8. Wang YL, Zhang R: [Professor Sun Shen-tian's experience in treatment of mental diseases]. Zhongguo Zhen Jiu; 2009 Aug;29(8):639-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In treating mental diseases, professor SUN considers that the morbidity of mental diseases is mainly related to the malfunction of brain, therefore regulating mind is the key to treat this kind of disease, Baihui (GV 20), Yintang (EX-HN 3), emotional area and Zone 1 of SUN's abdominal acupoints are often selected.
  • This present article introduces the principle of treatment based on syndrome differentiation and routine selecting acupoints, attached with four effective cases in treating mental diseases by professor SUN applying "the methods of regulating vitality and increasing intelligence".

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  • (PMID = 19947269.001).
  • [ISSN] 0255-2930
  • [Journal-full-title] Zhongguo zhen jiu = Chinese acupuncture & moxibustion
  • [ISO-abbreviation] Zhongguo Zhen Jiu
  • [Language] chi
  • [Publication-type] Biography; Case Reports; English Abstract; Historical Article; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Personal-name-as-subject] Sun ST
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9. Sun DZ, Xu L, Wei PK, Liu L, He J: Syndrome differentiation in traditional Chinese medicine and E-cadherin/ICAM-1 gene protein expression in gastric carcinoma. World J Gastroenterol; 2007 Aug 28;13(32):4321-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Syndrome differentiation in traditional Chinese medicine and E-cadherin/ICAM-1 gene protein expression in gastric carcinoma.
  • AIM: To explore the syndrome differentiation in traditional Chinese medicine (TCM) and gene protein expression in gastric carcinoma.
  • METHODS: Preoperative data of gastric cancer cases were collected from the General Surgery Department and classified according to the criteria for syndrome differentiation in TCM.
  • The difference in E-cad expression was significant between the different syndrome differentiation types in TCM (P < 0.01).
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Female. Gene Expression Regulation, Neoplastic. Humans. Male. Middle Aged. Syndrome

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  • (PMID = 17708604.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cadherins; 126547-89-5 / Intercellular Adhesion Molecule-1
  • [Other-IDs] NLM/ PMC4250857
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10. Shen SY, Fu XD, Zhang YW, Dong XL, Zhao LJ, Cai H: [Relationship between lupus headache and headache due to internal injury in traditional Chinese medicine]. Zhong Xi Yi Jie He Xue Bao; 2009 May;7(5):407-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Although early diagnosis is essential for good outcomes, the diagnosis method is rather confused in the world.
  • There still exist some limitations in the proposal of clinical classification of headache from ACR and International Headache Society (IHS), and the proposal does not mention the classification of headache related to psychiatric damage.
  • Syndrome differentiation treatment according to deficiency in the root and excess in the branch and the therapy for activating blood to dredge collaterals maybe have great advantages in treatment of the headache in SLE.
  • [MeSH-major] Headache / diagnosis. Lupus Erythematosus, Systemic / complications. Medicine, Chinese Traditional. Vascular Headaches / etiology
  • [MeSH-minor] Diagnosis, Differential. Drugs, Chinese Herbal / therapeutic use. Humans. Phytotherapy

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  • (PMID = 19435552.001).
  • [ISSN] 1672-1977
  • [Journal-full-title] Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
  • [ISO-abbreviation] Zhong Xi Yi Jie He Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Drugs, Chinese Herbal
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11. Stevenson GT: CD38 as a therapeutic target. Mol Med; 2006 Nov-Dec;12(11-12):345-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The list of candidate CD38-bearing neoplasms as targets for these antibody constructs can now be expanded to include acute promyelocytic leukemia, and possibly other myeloid leukemias, in which surface CD38 can be induced by retinoid treatment.
  • One caveat here is that evidence has been produced to suggest that CD38 promotes pulmonary manifestations of the hazardous retinoic acid syndrome.
  • [MeSH-minor] Animals. Antibodies, Monoclonal / therapeutic use. Cell Line, Tumor. Humans. Leukemia / immunology. Lymphoma, B-Cell / immunology. Mice. Mice, SCID. Multiple Myeloma / immunology. Transplantation, Heterologous

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  • (PMID = 17380203.001).
  • [ISSN] 1076-1551
  • [Journal-full-title] Molecular medicine (Cambridge, Mass.)
  • [ISO-abbreviation] Mol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antigens, CD; EC 3.2.2.5 / Antigens, CD38
  • [Other-IDs] NLM/ PMC1829201
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12. Chen WX, Wu QY, Chen BC, Ke MY, Guo LC, Liu XJ: [Measurement study of disease differentiation treatment based on standard syndrome differentiation]. Zhong Xi Yi Jie He Xue Bao; 2009 May;7(5):401-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Measurement study of disease differentiation treatment based on standard syndrome differentiation].
  • The basic premise of syndrome essence discussion is the standardization of traditional Chinese medicine (TCM) syndrome type.
  • However, there still exists confusion regarding the standardization of TCM syndrome differentiation treatment, and the guidelines for TCM syndrome differentiation could not really be used for guiding clinical treatment.
  • The fundamental research of TCM syndrome based on the differentiation and classification of diseases is the main method for studying the standardization of TCM syndrome type.
  • The accuracy quantification of symptoms is the powerful guarantee for authenticity and reliability of the results from standardization study of syndrome type.
  • The correct choice for statistical methods gives powerful technical support to determine the differentiation threshold.
  • The unified scales, expert discussions and complex scientific theories are the best methods for current research on standardization of syndrome type.
  • The correlation study of syndrome type and physicochemical indexes cannot reflect the syndrome type completely.
  • It is supposed to establish the treatment principles according to the main pathological changes of diseases on the basis of the standardization of TCM syndrome differentiation.
  • [MeSH-major] Diagnosis, Differential. Medicine, Chinese Traditional / standards

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  • (PMID = 19435551.001).
  • [ISSN] 1672-1977
  • [Journal-full-title] Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
  • [ISO-abbreviation] Zhong Xi Yi Jie He Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Drugs, Chinese Herbal
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13. Mao B, Li W, Liang WQ: [Visceral syndrome differentiation in traditional Chinese medicine and the changes of nutrition status or blood gas analysis in patients with chronic obstructive pulmonary disease]. Zhong Xi Yi Jie He Xue Bao; 2007 Sep;5(5):506-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Visceral syndrome differentiation in traditional Chinese medicine and the changes of nutrition status or blood gas analysis in patients with chronic obstructive pulmonary disease].
  • OBJECTIVE: To investigate the relationship between visceral syndrome differentiation in traditional Chinese medicine (TCM) and the changes of nutrition status or blood gas analysis in patients with chronic obstructive pulmonary disease (COPD).
  • METHODS: Sixty patients with COPD in stable phase were divided into dysfunction of lung (DL, n=20) group, dysfunction of lung and spleen (DLS, n=16) group and dysfunction of lung, spleen and kidney (DLSK, n=24) group according to syndrome differentiation of TCM.
  • [MeSH-major] Blood Gas Analysis. Diagnosis, Differential. Medicine, Chinese Traditional. Nutritional Status. Pulmonary Disease, Chronic Obstructive / diagnosis

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  • (PMID = 17854549.001).
  • [ISSN] 1672-1977
  • [Journal-full-title] Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
  • [ISO-abbreviation] Zhong Xi Yi Jie He Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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14. Zhang ZL, Zhu MP, Liu Q, Lei YX: The clinical experiences of Dr. CAI Gan in treating chronic constipation. J Tradit Chin Med; 2009 Sep;29(3):205-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Meanwhile he attaches great importance to syndrome differentiation and comprehensive regulation and treatment.

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  • (PMID = 19894386.001).
  • [ISSN] 0255-2922
  • [Journal-full-title] Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan
  • [ISO-abbreviation] J Tradit Chin Med
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Drugs, Chinese Herbal
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15. Li T: Treatment of migraine from the view of disease diagnosis and syndrome differentiation in combination. Chin J Integr Med; 2009 Aug;15(4):251-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Treatment of migraine from the view of disease diagnosis and syndrome differentiation in combination.
  • [MeSH-major] Migraine Disorders / complications. Migraine Disorders / diagnosis. Migraine Disorders / therapy
  • [MeSH-minor] Analgesia / methods. Diagnosis, Differential. Disease Susceptibility / diagnosis. Drugs, Chinese Herbal / chemistry. Drugs, Chinese Herbal / therapeutic use. Humans. Medicine, Chinese Traditional / methods. Somatoform Disorders / complications. Somatoform Disorders / diagnosis. Somatoform Disorders / therapy. Syndrome

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  • (PMID = 19688311.001).
  • [ISSN] 1672-0415
  • [Journal-full-title] Chinese journal of integrative medicine
  • [ISO-abbreviation] Chin J Integr Med
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Drugs, Chinese Herbal
  • [Number-of-references] 5
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16. Zhao AG, Cao W, Xu Y, Zhao G, Liu BY, Cai Y, Yang JZ, Gu Y, Yuan W, Zhu YJ, Han YY, Yang JY: [Survival benefit of an herbal formula for invigorating spleen for elderly patients with gastric cancer]. Zhong Xi Yi Jie He Xue Bao; 2010 Mar;8(3):224-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To analyze the prognostic factors of 220 elderly patients with gastric cancer, and to further study the efficacy of an herbal formula for invigorating spleen and it modifications based on syndrome differentiation of TCM in treatment of gastric cancer in elderly patients and the influence on prognosis.
  • [MeSH-major] Adenocarcinoma / drug therapy. Drugs, Chinese Herbal / therapeutic use. Stomach Neoplasms / drug therapy
  • [MeSH-minor] Aged. Aged, 80 and over. Disease-Free Survival. Drug Combinations. Female. Humans. Male. Medicine, Chinese Traditional. Prognosis. Prospective Studies. Spleen. Survival

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  • (PMID = 20226143.001).
  • [ISSN] 1672-1977
  • [Journal-full-title] Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
  • [ISO-abbreviation] Zhong Xi Yi Jie He Xue Bao
  • [Language] chi
  • [Publication-type] Controlled Clinical Trial; English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Drug Combinations; 0 / Drugs, Chinese Herbal
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17. Li YM, Zhuang LX, Lai XS, Jiang GH: [Effects of electroacupuncture on plasma vasoactive intestinal peptide and substance P in perennial allergic rhinitis patients]. Zhen Ci Yan Jiu; 2007 Apr;32(2):136-8
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  • Patients in EA group were treated with EA (5-10 mA, 80-100 Hz, and 30 min of stimulation) of Sphenopalatine ganglion area, Yingxiang (LI 20), Shangyingxiang (EX-HN 8), Yintang (EX-HN 3), supplemented with other acupoints according to syndrome-differentiation (once daily, 10 days being a therapeutic course).
  • CONCLUSION: EA can effectively relieve perennial allergic rhinitis patients' clinical symptoms, which is closely related to its functions in lowering plasma VIP and SP levels.

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  • (PMID = 17650661.001).
  • [ISSN] 1000-0607
  • [Journal-full-title] Zhen ci yan jiu = Acupuncture research
  • [ISO-abbreviation] Zhen Ci Yan Jiu
  • [Language] CHI
  • [Publication-type] English Abstract; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 33507-63-0 / Substance P; 37221-79-7 / Vasoactive Intestinal Peptide
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18. Sun LQ, Yang Y, Zheng W: [Relationship between syndrome differentiation of traditional Chinese medicine and vascular endothelial function in patients with diabetic arterial occlusion of lower extremities]. Zhong Xi Yi Jie He Xue Bao; 2007 Nov;5(6):621-4
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  • [Title] [Relationship between syndrome differentiation of traditional Chinese medicine and vascular endothelial function in patients with diabetic arterial occlusion of lower extremities].
  • OBJECTIVE: To investigate the relationship between syndrome differentiation of traditional Chinese medicine (TCM) and characteristic changes of vascular endothelial function in patients with diabetic arterial occlusion (DAO) of lower extremities.
  • Twenty patients among them were attributed to blood stasis syndrome (group A1), and the others were attributed to syndrome of pathogenic dampness-heat attacking the lower limb (group A2) according to syndrome differentiation type of TCM.
  • CONCLUSION: Our findings indicate that endothelial dysfunction may play an important role in the pathogenesis of DAO and may be associated with syndrome differentiation of TCM.
  • [MeSH-major] Arterial Occlusive Diseases / physiopathology. Diabetes Mellitus, Type 2 / complications. Diagnosis, Differential. Endothelium, Vascular / physiopathology. Medicine, Chinese Traditional

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  • (PMID = 17997934.001).
  • [ISSN] 1672-1977
  • [Journal-full-title] Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
  • [ISO-abbreviation] Zhong Xi Yi Jie He Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Endothelin-1; 31C4KY9ESH / Nitric Oxide; 54397-85-2 / Thromboxane B2; 58962-34-8 / 6-Ketoprostaglandin F1 alpha
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19. Jiang J: [Reflections on clinical practice of traditional Chinese medicine through treatment of individual cases of urinary tract infection]. Zhong Xi Yi Jie He Xue Bao; 2008 Dec;6(12):1217-20
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  • The problems existing in clinical practice of traditional Chinese medicine were considered and discussed by analyzing and comparing the similarities and differences of syndrome differentiation treatment of the 9 cases.

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  • (PMID = 19063832.001).
  • [ISSN] 1672-1977
  • [Journal-full-title] Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
  • [ISO-abbreviation] Zhong Xi Yi Jie He Xue Bao
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Drugs, Chinese Herbal
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20. Li XH, Guo XD: [Thinking about acupuncture for treatment of simple obesity]. Zhongguo Zhen Jiu; 2009 Jul;29(7):569-74
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  • In the viewpoint of traditional Chinese medicine (TCM), the authors consider that simple obesity is not a disease, which does not fit to be treated according to the models of diagnosis and treatment in TCM.
  • Considering its cause, pathogenesis, syndrome differentiation, principles and methods of treatment, as well as experimental study, etc. , the authors point out that the true effects of acupuncture on weight-loss should be investigated alone and avoid the influence of diet and exercise.

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  • (PMID = 19835127.001).
  • [ISSN] 0255-2930
  • [Journal-full-title] Zhongguo zhen jiu = Chinese acupuncture & moxibustion
  • [ISO-abbreviation] Zhongguo Zhen Jiu
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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21. Gao CY, Duan WS, Pan SZ: [Relationship of TCM syndrome differentiation and manifestation of electrophysiology in patients with peripheral diabetic neuropathy]. Zhongguo Zhong Xi Yi Jie He Za Zhi; 2007 Aug;27(8):686-8
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  • [Title] [Relationship of TCM syndrome differentiation and manifestation of electrophysiology in patients with peripheral diabetic neuropathy].
  • OBJECTIVE: To study the relationship between TCM syndrome type and electrophysiological changes of nerves in patients with peripheral diabetic neuropathy (PDN).
  • METHODS: TCM syndrome differentiation of 87 patients with PDN were performed, and the sensory nerve conduction velocity (SCV) of common peroneal nerve and the motor nerve conduction velocity (MCV) of sural nerve were measured as well using surface electrodes.
  • CONCLUSION: Obvious changes of MCV and SCV could be found in PDN patients of TCM yang-deficiency syndrome, so the abnormal velocity of nerve conduction could be taken as a referential index for diagnosis of patients belonging to that type.

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  • (PMID = 17879528.001).
  • [ISSN] 1003-5370
  • [Journal-full-title] Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine
  • [ISO-abbreviation] Zhongguo Zhong Xi Yi Jie He Za Zhi
  • [Language] CHI
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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22. Li ZG: Comparative study on WHO Western Pacific Region and World Federation of Chinese Medicine Societies international standard terminologies on traditional medicine: syndrome differentiation according to eight principles (Part three). Zhong Xi Yi Jie He Xue Bao; 2010 Jun;8(6):594-7
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  • [Title] Comparative study on WHO Western Pacific Region and World Federation of Chinese Medicine Societies international standard terminologies on traditional medicine: syndrome differentiation according to eight principles (Part three).

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  • (PMID = 20550884.001).
  • [ISSN] 1672-1977
  • [Journal-full-title] Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
  • [ISO-abbreviation] Zhong Xi Yi Jie He Xue Bao
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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23. Wang ZL, He HQ, Huang D, Shi CG: [Effect of integral syndrome differentiation acupuncture on the tear film stability in the patient of xerophthalmia]. Zhongguo Zhen Jiu; 2005 Jul;25(7):460-3
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  • [Title] [Effect of integral syndrome differentiation acupuncture on the tear film stability in the patient of xerophthalmia].
  • The acupuncture group 1 were treated with acupuncture based on syndrome types, and the acupuncture group 2 with acupuncture at local acupoints, and the control group with dripping of artificial tears.
  • CONCLUSION: The integral syndrome differentiation acupuncture can improve secretion of tear, increase stability of tear film, improve local symptoms of eyes with a therapeutic effect better than acupuncture at local acupoints and artificial tears.
  • [MeSH-minor] Acupuncture Points. Acupuncture Therapy. Humans. Syndrome

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  • (PMID = 16309130.001).
  • [ISSN] 0255-2930
  • [Journal-full-title] Zhongguo zhen jiu = Chinese acupuncture & moxibustion
  • [ISO-abbreviation] Zhongguo Zhen Jiu
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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24. Yang X, Zhu LJ, Ji YL: [Expression of TNF-alpha signaling adapter proteins in peripheral blood mononuclear cells in lupus nephritis patients of different TCM asthenia syndromes]. Zhongguo Zhong Xi Yi Jie He Za Zhi; 2009 Jan;29(1):34-9
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  • Methods Fifty-one inpatients with LN were differentiated according to TCM syndrome differentiation, 13 cases of yin-deficiency with inner heat syndrome (A); 26 cases of both qi-yin deficiency syndrome (B), 12 cases of Pi-Shen yang-deficiency syndrome (C).
  • (1) As compared with the healthy subjects, expression of TRADD mRNA in patients of syndrome A, B and C was lowered to 0.54, 0.32, and 0.38-fold, respectively (P < 0.05, P < 0.01), showing insignificant difference among the three syndromes;.
  • (2) FADD mRNA lowered to 0.79, 0.62, and 0.72-fold respectively, only with significance shown in syndrome B (P < 0.05);.
  • (3) RIP-1 mRNA lowered to 0.79, 0.50, and 0.60-fold respectively with significance shown in syndrome B and C (P < 0.01, P < 0.05), and insignificant difference was shown among the three syndromes;.
  • (4) TRAF-2 lowered to 0.70, 0.52, and 0.50-fold respectively (P < 0.01, P < 0.01, P = 0.07), significance shown in syndrome B and C (P < 0.01), but with insignificant difference among the three;.
  • (6) IL-1beta in syndrome A was apparently lower ed to the normal range and also lower than that in the other two syndromes (both P < 0.05).
  • CONCLUSIONS: Expressions of TRADD, FADD, RIP-1 and TRAF-2 mRNA decreased in all the patients of various TCM asthenia syndromes, the decrement in patients of syndrome B and C was lesser than that in syndrome A.
  • These abnormal low expressions of signal proteins might be the substantial bases for asthenia syndromes of LN patients, and the apoptotic signal mediated by them may involve in the formation of asthenia syndrome in LN.

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  • (PMID = 19338150.001).
  • [ISSN] 1003-5370
  • [Journal-full-title] Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine
  • [ISO-abbreviation] Zhongguo Zhong Xi Yi Jie He Za Zhi
  • [Language] CHI
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / FADD protein, human; 0 / Fas-Associated Death Domain Protein; 0 / RNA, Messenger; 0 / TNF Receptor-Associated Death Domain Protein; 0 / TNF Receptor-Associated Factor 2; 0 / Tumor Necrosis Factor-alpha; EC 2.7.11.1 / RIPK1 protein, human; EC 2.7.11.1 / Receptor-Interacting Protein Serine-Threonine Kinases
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25. Hou EC, Lu YX: [Primary hepatocarcinoma treated by traditional Chinese medicine combined with transcatheter arterial chemoembolization]. Zhongguo Zhong Xi Yi Jie He Za Zhi; 2009 Mar;29(3):225-7
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  • The TCM used was prescribed according to syndrome differentiation.

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  • (PMID = 19548439.001).
  • [ISSN] 1003-5370
  • [Journal-full-title] Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine
  • [ISO-abbreviation] Zhongguo Zhong Xi Yi Jie He Za Zhi
  • [Language] CHI
  • [Publication-type] English Abstract; Journal Article; Randomized Controlled Trial
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Drugs, Chinese Herbal
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26. Wang XF, Liu F, Dong D: [Evaluation on clinical efficacy of treatment of children pneumonia by combined internal-external therapy of TCM]. Zhongguo Zhong Xi Yi Jie He Za Zhi; 2005 Jun;25(6):537-9
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  • Besides the basic treatment of western medicine, to the 406 children in the treated group internal administering of Chinese recipe prescribed according to syndrome differentiation and external applying of Fuxiong plaster were given additionally, while to the 411 children in the control group simulative placeboes were given for instead.
  • The clinical efficacy of treatment on disease and syndrome, improvement of TCM syndrome and physical signs of lung between the two groups were compared after treatment.
  • RESULTS: The cured-markedly effective rate of treatment on disease and syndrome was 97.3%, 95.1% in the treated group and 89.8%, 86.6% in the control group, respectively, the differences of the two indexes between the two groups were significant (P < 0.05).

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  • (PMID = 16025971.001).
  • [ISSN] 1003-5370
  • [Journal-full-title] Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine
  • [ISO-abbreviation] Zhongguo Zhong Xi Yi Jie He Za Zhi
  • [Language] CHI
  • [Publication-type] Clinical Trial; English Abstract; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Drugs, Chinese Herbal
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27. Lu AP: [Making repeated clinical trials aiming at finding specific indications is the way for improving clinical efficacy of traditional Chinese medicine]. Zhongguo Zhong Xi Yi Jie He Za Zhi; 2006 Jul;26(7):588-9
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  • From the view of syndrome differentiation theory of traditional Chinese medicine, the previous therapeutic process is also a diagnostic process for the following therapeutic course, so to make repeated clinical trials aiming at finding specific indications would be one of the important ways to improve the clinical efficacy of traditional Chinese medicine.

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  • (PMID = 16983908.001).
  • [ISSN] 1003-5370
  • [Journal-full-title] Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine
  • [ISO-abbreviation] Zhongguo Zhong Xi Yi Jie He Za Zhi
  • [Language] CHI
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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28. Kim LW, Zhu J: Acupuncture for essential hypertension. Altern Ther Health Med; 2010 Mar-Apr;16(2):18-29
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To assess the efficacy of acupuncture for treatment of essential hypertension and the efficacy of acupuncture using prescription adhering to the principles of "syndrome differentiation."
  • In high-quality trials, blood pressure was significantly lower in treatments of acupuncture plus antihypertensive drug arms than in sham-acupuncture plus hypertensive drug arms (two comparisons: SBP: -5.72 mmHg, -8.77 to -2.68; DBP: -2.80, -5.07 to -0.54), with no significant heterogeneity.
  • As for trials using prescription adhering to the principles of syndrome differentiation, we found a significant blood pressure reduction with acupuncture arms in comparison with control arms (11 comparisons: SBP: -6.46 mmHg, -8.04 to -4.87; DBP: -3.07, -4.17 to -1.96) with no significant heterogeneity.
  • In contrast, in trials not using prescription adhering to the principles of syndrome differentiation, we found no significant reduction in blood pressure with acupuncture arms in comparison with control arms (eight comparisons: SBP: -1.55 mmHg, -5.39 to 2.29; DBP: -2.12, -4.97 to 0.73) with significant heterogeneity.

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  • (PMID = 20232615.001).
  • [ISSN] 1078-6791
  • [Journal-full-title] Alternative therapies in health and medicine
  • [ISO-abbreviation] Altern Ther Health Med
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antihypertensive Agents
  • [Number-of-references] 51
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29. Fang ZQ, Pan ZQ, Lu WL, Liu XM, Guan DY, Liang C: [Methodology and purposes of establishing mouse and rat models for syndrome differentiation and treatment]. Zhong Xi Yi Jie He Xue Bao; 2009 Oct;7(10):907-12
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  • [Title] [Methodology and purposes of establishing mouse and rat models for syndrome differentiation and treatment].
  • Methodology of syndrome differentiation and syndrome-based treatment in rats and mice has professional characteristics and caters to the research and development of traditional Chinese medicine (TCM).
  • Diagnosis and syndrome differentiation can be done to the rats and mice, and information collected by the four diagnostic methods from the experimental animals meets the requirements of treatment based on syndrome differentiation.
  • 2) Standardized and quantified four diagnostic methods and syndrome differentiation for rats and mice can be established, and are operational and applicable for general use.
  • 3) There exists constitution and syndrome diversity in normal rats and mice.
  • A spontaneous syndrome can develop in diseased rats and mice, and it can be accompanied by or even change to another syndrome, similar to that in human beings.
  • 5) Individualized treatment based on syndrome differentiation, as well as quantified evaluation and comparison of the treatment efficacy can be done in the rat and mouse models of syndromes.
  • The established methodology and criteria for syndrome differentiation and syndrome-based treatment in rats and mice can be used in the following four research fields:.
  • 1) syndrome identification on rat or mouse models;.
  • 2) research on the basic theories of TCM, such as the research on the viscera manifestation theory, the material base of syndromes, function mechanisms of the treatment based on syndrome differentiation, and the diagnostics of TCM;.
  • 3) study in clinical subject of TCM, such as evaluation and comparison of the efficacy of treatment based on syndrome differentiation, protocol optimization of syndrome differentiation and treatment, and preventive treatment of diseases;.
  • [MeSH-major] Medicine, Chinese Traditional / methods. Syndrome
  • [MeSH-minor] Animals. Diagnosis, Differential. Disease Models, Animal. Drugs, Chinese Herbal / therapeutic use. Humans. Mice. Rats

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  • (PMID = 19828100.001).
  • [ISSN] 1672-1977
  • [Journal-full-title] Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
  • [ISO-abbreviation] Zhong Xi Yi Jie He Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Drugs, Chinese Herbal
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30. Li L, Li XD, Song JN, Fang XZ, Miao Y, Lin Q: [Applying matching matrix, factor analysis and clustering analysis to investigation of characteristics of syndromes of phlegm and blood stasis in patients with coronary heart disease]. Zhong Xi Yi Jie He Xue Bao; 2006 Jul;4(4):343-7
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  • OBJECTIVE: To investigate the characteristics of syndromes of phlegm and blood stasis in patients with coronary heart disease by multiple statistical methods of matching matrix, factor analysis and clustering analysis, and to provide some references for classification and normalization of diagnosis of syndromes of phlegm and blood stasis of coronary heart disease.
  • METHODS: The correlations among 46 kinds of symptoms in syndrome of non-phlegm and non-blood stasis, syndrome of blood stasis, syndrome of phlegm and syndrome of phlegm-blood stasis blocking in 200 patients with coronary heart disease were analyzed by matching matrix, factor analysis and clustering analysis.
  • RESULTS: The manifestations of tongue and pulse in syndromes of phlegm and blood stasis were significantly different from those in syndrome of non-phlegm and non-blood stasis.
  • The pathogenesis of viscera in syndromes of phlegm and blood stasis lied in the heart and kidney, and the syndrome of deficiency of heart qi was the most common one while the syndrome of deficiency of kidney qi took the secondary place.
  • The syndrome of phlegm was often accompanied by syndrome of deficiency of spleen qi.
  • Only 15 ones of 46 clinical symptoms showed high frequency in concomitant appearance in syndrome of blood stasis, syndrome of phlegm and syndrome of phlegm-blood stasis blocking.
  • Apart from having the common symptoms in syndrome of deficiency in origin, the syndrome of phlegm especially showed white and greasy fur and slippery pulse as well as distention and fullness of chest and abdominal distension; the syndrome of blood stasis showed purplish tongue and ecchymosis on tongue as well as fixed pain; and the syndrome of phlegm-blood stasis blocking showed the main symptoms of both syndrome of phlegm and syndrome of blood stasis.
  • CONCLUSION: The statistical methods of matching matrix, factor analysis and clustering analysis are convenient, and can definitely indicate the clinical characteristics and syndrome differentiation of viscera of different syndromes of phlegm and blood stasis, which are beneficial to further research of diagnosis and differentiation of such syndromes of coronary heart disease.
  • [MeSH-minor] Cluster Analysis. Diagnosis, Differential. Factor Analysis, Statistical. Humans

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  • (PMID = 16834968.001).
  • [ISSN] 1672-1977
  • [Journal-full-title] Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
  • [ISO-abbreviation] Zhong Xi Yi Jie He Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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31. Zhan Q, Meng R: [Initial exploration on the new thought for diagnosis and treatment of systemic lupus erythematosus by integrative Chinese and Western medicine]. Zhongguo Zhong Xi Yi Jie He Za Zhi; 2006 Aug;26(8):743-5
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  • [Title] [Initial exploration on the new thought for diagnosis and treatment of systemic lupus erythematosus by integrative Chinese and Western medicine].
  • Since the authors held that the previous clinical disease-syndrome integrative thought can not embody the regularity in the diagnosis and treatment of SLE, in order to establish a novel operable thought of syndrome differentiation which could reflect the clinical practice of SLE, they suggested, in accordance with their clinical experience, that the basis for integration of the disease and its syndromes should not be SLE itself but the clinical manifestations of the organs and systems, such as fever, nervous system injury, lupus kidney, thrombocytopenic purpura of SLE, etc.
  • They claimed that the new clinical thought of diagnosis and treatment will contribute to conduct systematic and standard research on SLE, and the regulation of TCM therapy based on syndrome differentiation would be more closer to the clinical practice of SLE.

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  • (PMID = 16970103.001).
  • [ISSN] 1003-5370
  • [Journal-full-title] Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine
  • [ISO-abbreviation] Zhongguo Zhong Xi Yi Jie He Za Zhi
  • [Language] CHI
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Drugs, Chinese Herbal
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32. Tao L, Zhu YJ, Lu XM, Gu Y, Zhao AG, Zheng J, Fu CG, Yang JK: [Clinical study on survival benefit for elderly patients with resected stage II or III colorectal cancer based on traditional Chinese medicine syndrome differentiation and treatment]. Zhong Xi Yi Jie He Xue Bao; 2010 Dec;8(12):1159-64
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  • [Title] [Clinical study on survival benefit for elderly patients with resected stage II or III colorectal cancer based on traditional Chinese medicine syndrome differentiation and treatment].
  • OBJECTIVE: This research aimed to evaluate the survival benefit of using TCM syndrome differentiation treatment for elderly patients with stage II or III colorectal cancer.
  • CONCLUSION: TCM syndrome differentiation and treatment is important for improving the prognosis of stage II or III colorectal cancer in elderly patients.
  • [MeSH-major] Colorectal Neoplasms / drug therapy. Drugs, Chinese Herbal / therapeutic use. Phytotherapy

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  • (PMID = 21144459.001).
  • [ISSN] 1672-1977
  • [Journal-full-title] Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
  • [ISO-abbreviation] Zhong Xi Yi Jie He Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Drugs, Chinese Herbal
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33. Findling JW, Raff H: Cushing's Syndrome: important issues in diagnosis and management. J Clin Endocrinol Metab; 2006 Oct;91(10):3746-53
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  • [Title] Cushing's Syndrome: important issues in diagnosis and management.
  • CONTEXT: The diagnosis, differential diagnosis, and treatment of Cushing's syndrome are challenging problems in clinical endocrinology.
  • We focus on critical questions addressing screening for Cushing's syndrome, differentiation of Cushing's subtypes, and treatment options.
  • EVIDENCE SYNTHESIS: Although this article represents our opinion, it draws heavily on a recent consensus statement from experts in the field and a recent monograph on Cushing's syndrome.
  • 1) measurement of late-night or bedtime salivary cortisol is a useful approach to screen for Cushing's syndrome;.
  • 2) measurement of suppressed plasma ACTH by immunometric assay is useful to differentiate ACTH-dependent and -independent Cushing's syndrome;.
  • 4) computed tomography of the chest and abdomen and somatostatin receptor scintigraphy should be performed in patients with the occult ectopic ACTH syndrome; and 5) patients with Cushing's disease should be referred to a neurosurgeon with extensive experience operating on corticotroph microadenomas.
  • [MeSH-major] Cushing Syndrome / diagnosis

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  • (PMID = 16868050.001).
  • [ISSN] 0021-972X
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 7S5I7G3JQL / Dexamethasone; 9002-60-2 / Adrenocorticotropic Hormone; WI4X0X7BPJ / Hydrocortisone
  • [Number-of-references] 84
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34. Yu XW: [Exertion of dredging and guiding technique in Zhu Bing Yuan Hou Lun ( General Treatise on Causes and Manifestations of All Diseases)]. Zhonghua Yi Shi Za Zhi; 2006 Jul;36(3):142-4
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  • The "six- word pithy knack" is determined firstly in the book and paired with different Zang-fu organs, as well as emphasizing the performance of the technique based on syndrome differentiation.
  • [MeSH-minor] China. Humans. Syndrome

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  • (PMID = 17278435.001).
  • [ISSN] 0255-7053
  • [Journal-full-title] Zhonghua yi shi za zhi (Beijing, China : 1980)
  • [ISO-abbreviation] Zhonghua Yi Shi Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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35. You JS, Huang Y, Cai YF, Guo JW, Liang WX, Huang PX, Liu MC: [Characteristics of traditional Chinese medicine syndromes in patients with acute ischemic stroke of yin or yang syndrome: a multicenter trial]. Zhong Xi Yi Jie He Xue Bao; 2008 Apr;6(4):346-51
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  • [Title] [Characteristics of traditional Chinese medicine syndromes in patients with acute ischemic stroke of yin or yang syndrome: a multicenter trial].
  • OBJECTIVE: To explore the composition characteristics of traditional Chinese medicine (TCM) syndromes in patients with acute ischemic stroke of yin or yang syndrome by investigating the characteristics of TCM syndromes at different periods after onset.
  • METHODS: One thousand two hundred and forty-six patients with acute ischemic stroke were admitted in twenty hospitals.
  • According to the "diagnostic criteria of syndrome differentiation of stroke", the characteristics of syndromes in the patients were investigated at the periods of 1-3 days, 4-10 days and 11-30 days after they had ischemic stroke.
  • General distribution of six basic syndromes was compared between the patients with yin syndrome and the patients with yang syndrome at the three periods.
  • The six basic syndromes were wind syndrome, pathogenic fire syndrome, phlegm syndrome, blood stasis syndrome, qi deficiency syndrome, and syndrome of yin deficiency and yang hyperactivity.
  • The percentages of syndromes of wind, pathogenic fire, phlegm, and yin deficiency and yang hyperactivity were higher (P<0.01), and the percentages of syndromes of blood stasis and qi deficiency were lower (P<0.05, P<0.01) in patients with yang syndrome than in patients with yin syndrome.
  • The percentages of complex syndromes of four or five syndromes were higher, and the percentages of single-syndromes and complex syndromes of two syndromes were lower in patients with yang syndrome than in patients with yin syndrome (P<0.05, P<0.01).
  • The most frequent complex syndromes in patients with yin syndrome were complex syndrome of wind, phlegm, blood stasis and qi deficiency, and complex syndrome of wind, phlegm and qi deficiency; while the most frequent complex syndromes in patients with yang syndrome were complex syndrome of wind, pathogenic fire, phlegm and qi deficiency, and complex syndrome of wind, pathogenic fire and phlegm.
  • CONCLUSION: The main discrimination between the yin and yang syndromes is that the yang syndrome is characterized by pathogenic fire.
  • The syndromes of phlegm, qi deficiency, and blood stasis are not associated with the diagnosis of yin or yang syndrome.
  • [MeSH-major] Cerebral Infarction / classification. Diagnosis, Differential. Medicine, Chinese Traditional / standards. Stroke / classification. Yin-Yang
  • [MeSH-minor] Humans. Qi. Reference Standards. Syndrome. Yang Deficiency / diagnosis. Yin Deficiency / diagnosis

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  • (PMID = 18405599.001).
  • [ISSN] 1672-1977
  • [Journal-full-title] Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
  • [ISO-abbreviation] Zhong Xi Yi Jie He Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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36. Liu P, Hu YY, Ni LQ: [On establishing comparative reference system for syndrome classification study from the thinking characteristics of syndrome differentiation dependent therapy]. Zhongguo Zhong Xi Yi Jie He Za Zhi; 2006 May;26(5):451-4
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  • [Title] [On establishing comparative reference system for syndrome classification study from the thinking characteristics of syndrome differentiation dependent therapy].
  • To create a comparative referential system for syndrome classification study by viewing from the thinking characteristics of TCM on syndrome differentiation dependent therapy (SDDT), through analyzing the thinking process of SDDT, and the basic features of disease, syndrome and prescription, combining the basic principles of modern evidence-based medicine and feasibility of establishing integrative disease-syndrome animal model.
  • The practice of creating a comparative referential system based on clinical efficacy of prescription was discussed around syndrome pathogenesis and its relationship with disease and prescription, which was one of the important scientific problems in TCM syndrome study.
  • The authors hold that, it may be one of the available approaches for the present study on integration of disease with syndrome by way of insisting on the thinking pathway of stressing the characteristics of TCM and intermerging with modern scientific design; on taking the efficacy of prescription as the comparative reference system to accumulate and improve unceasingly according to the TCM method of syndrome diagnosis inferred from effect of prescription with reverse thought (i.e., to differentiate syndrome from the effect of prescription), and thus build up the syndrome diagnostic standard on the solid clinical and scientific base.

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  • (PMID = 16883917.001).
  • [ISSN] 1003-5370
  • [Journal-full-title] Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine
  • [ISO-abbreviation] Zhongguo Zhong Xi Yi Jie He Za Zhi
  • [Language] CHI
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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37. He YH: General survey of traditional Chinese medicine and Western medicine researches on tumor metastasis. Chin J Integr Med; 2006 Mar;12(1):75-80
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  • Aimed at solving the difficult problems in metastasis of tumor, many TCM practitioners on the basis of syndrome differentiation have raised theories about the cause of tumor metastasis.

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  • [Cites] Zhongguo Zhong Xi Yi Jie He Za Zhi. 2000 Aug;20(8):583-5 [11789187.001]
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  • (PMID = 16571292.001).
  • [ISSN] 1672-0415
  • [Journal-full-title] Chinese journal of integrative medicine
  • [ISO-abbreviation] Chin J Integr Med
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Drugs, Chinese Herbal
  • [Number-of-references] 33
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38. Shao P, Huang XT, Zjang F: [Research on relationship of syndrome type and parameters of hemorheology and platelet activation in patients with acute gout arthritis of dampness-heat blockage type and stasis-heat accumulate type]. Zhongguo Zhong Xi Yi Jie He Za Zhi; 2006 Nov;26(11):992-4
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  • [Title] [Research on relationship of syndrome type and parameters of hemorheology and platelet activation in patients with acute gout arthritis of dampness-heat blockage type and stasis-heat accumulate type].
  • OBJECTIVE: To study the relationship between syndrome type and the parameters of hemorrheology and platelet activation in patients with acute gout arthritis of dampness-heat blockage (DHB) type and stasis-heat accumulation (SHA) type.
  • METHODS: Forty patients with acute gouty arthritis were divided into 2 groups according to TCM syndrome differentiation, the DHB group (n=24) and the SHA group (n=16), and 20 healthy people were taken as the control group.
  • CONCLUSION: DHB type and SHA syndrome type of acute gout arthritis are correlated with parameters of hemorrheology and platelet activation, and the different levels of these pameters showed in the two types, may be the internal factors for their genesis.

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  • (PMID = 17186728.001).
  • [ISSN] 1003-5370
  • [Journal-full-title] Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine
  • [ISO-abbreviation] Zhongguo Zhong Xi Yi Jie He Za Zhi
  • [Language] CHI
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / P-Selectin; 0 / Platelet Activating Factor
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39. Li XP, Zheng CS, Hong ZJ: [Correlation between sex hormone and insulin and various TCM syndrome types in patients with polycystic ovarian syndrome]. Zhongguo Zhong Xi Yi Jie He Za Zhi; 2007 Nov;27(11):996-8
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  • [Title] [Correlation between sex hormone and insulin and various TCM syndrome types in patients with polycystic ovarian syndrome].
  • OBJECTIVE: To explore the relationships of sex hormone and insulin with various TCM syndrome types of polycystic ovarian syndrome (PCOS) and their significance.
  • METHODS: Levels of testosterone (T), follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL), estradiol (E2), and insulin (INS) in 120 patients with PCOS were determined respectively, among them, 30 patients were classified by TCM syndrome differentiation as Shen-yin deficiency type (SYiD), 30 as Shen-yang deficiency type (SYaD), 30 as Pi-yang deficiency type (PYD) and 30 as Gan-stagnancy transformed heat type (GSH).
  • CONCLUSION: Elevated level of T, LH and LH/FSH ratio, PRL and INS are correlated with the TCM syndrome type of SYiD, SYaD, GSH and PYD in patients with PCOS respectively, and being the clinical characteristics of the corresponding syndromes.


40. Jia LN, Wang XJ: [Clinical observation on treatment of 43 women with polycystic ovary syndrome based on syndrome differentiation]. Zhong Xi Yi Jie He Xue Bao; 2006 Nov;4(6):585-8
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  • [Title] [Clinical observation on treatment of 43 women with polycystic ovary syndrome based on syndrome differentiation].
  • OBJECTIVE: To investigate the therapeutic effect of treatment based on syndrome differentiation and its influence on the serum levels of testosterone and insulin in women with polycystic ovary syndrome (PCOS).
  • METHODS: Forty-three women, diagnosed with PCOS as well as syndrome of kidney yin deficiency or syndrome of spleen qi deficiency, were enrolled in the study.
  • Twenty-five PCOS women with syndrome of kidney yin deficiency were treated with traditional Chinese herbs for nourishing yin to reduce fire (nourishing yin group), and 18 PCOS women with syndrome of spleen qi deficiency were treated with herbs for invigorating spleen and replenishing qi (replenishing qi group).
  • RESULTS: Among the 43 cases, 20 cases had high serum testosterone level, in which 13 cases with syndrome of kidney yin deficiency, 7 cases with syndrome of spleen qi deficiency, but the difference had no statistic significance; 17 cases had high serum insulin level, in which 11 cases with syndrome of spleen qi deficiency, 6 cases with syndrome of kidney yin deficiency, the difference had statistic significance (P<0.05).
  • CONCLUSION: Traditional Chinese herbs for nourishing yin to reduce fire can significantly reduce the serum levels of testosterone and insulin in PCOS women with syndrome of kidney yin deficiency, and herbs for invigorating spleen and replenishing qi can significantly reduce the serum level of insulin in PCOS women with syndrome of spleen qi deficiency.
  • [MeSH-major] Medicine, Chinese Traditional. Phytotherapy. Polycystic Ovary Syndrome / drug therapy. Testosterone / blood
  • [MeSH-minor] Adolescent. Adult. Diagnosis, Differential. Drugs, Chinese Herbal / therapeutic use. Female. Humans. Insulin / blood. Qi. Yin Deficiency / drug therapy

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  • (PMID = 17090372.001).
  • [ISSN] 1672-1977
  • [Journal-full-title] Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
  • [ISO-abbreviation] Zhong Xi Yi Jie He Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Drugs, Chinese Herbal; 0 / Insulin; 3XMK78S47O / Testosterone
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41. Dore AI, Santana-Lemos BA, Coser VM, Santos FL, Dalmazzo LF, Lima AS, Jacomo RH, Elias J Jr, Falcão RP, Pereira WV, Rego EM: The association of ICAM-1 Exon 6 (E469K) but not of ICAM-1 Exon 4 (G241R) and PECAM-1 Exon 3 (L125V) polymorphisms with the development of differentiation syndrome in acute promyelocytic leukemia. J Leukoc Biol; 2007 Nov;82(5):1340-3
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  • [Title] The association of ICAM-1 Exon 6 (E469K) but not of ICAM-1 Exon 4 (G241R) and PECAM-1 Exon 3 (L125V) polymorphisms with the development of differentiation syndrome in acute promyelocytic leukemia.
  • The use of all trans-retinoic acid (ATRA) is the basis of treatment of acute promyelocytic leukemia (APL) and represents the paradigm of differentiation therapy.
  • In general, ATRA is well-tolerated but may be associated with a potentially lethal side-effect, referred to as retinoic acid or differentiation syndrome (DS).
  • The cellular and molecular mechanisms of DS are poorly understood and involve changes in the adhesive qualities and cytokine secretion of leukemic cells during ATRA-induced differentiation.
  • As leukocyte extravasation is a key event in DS pathogenesis, we analyzed the association between the polymorphisms at Exon 4 (G241R) and Exon 6 (E469K) of ICAM-1 and Exon 3 (L125V) of PECAM-1 genes with DS development in APL patients treated with ATRA and anthracyclines.
  • DS was diagnosed in 23/127 (18.1%) APL patients at an average of 11.5 days after the start of ATRA.
  • Our results suggest that susceptibility to DS in APL patients may be influenced by genetic variation in adhesion molecule loci.
  • [MeSH-major] Antigens, CD31 / genetics. Exons / genetics. Intercellular Adhesion Molecule-1 / genetics. Leukemia, Promyelocytic, Acute / genetics. Polymorphism, Genetic / genetics
  • [MeSH-minor] Adult. Antineoplastic Agents / adverse effects. Cell Differentiation. Diagnosis, Differential. Female. Humans. Male. Syndrome. Tretinoin / adverse effects

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  • (PMID = 17704297.001).
  • [ISSN] 0741-5400
  • [Journal-full-title] Journal of leukocyte biology
  • [ISO-abbreviation] J. Leukoc. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Antineoplastic Agents; 126547-89-5 / Intercellular Adhesion Molecule-1; 5688UTC01R / Tretinoin
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42. Tallman MS, Kim HT, Montesinos P, Appelbaum FR, de la Serna J, Bennett JM, Deben G, Bloomfield CD, Gonzalez J, Feusner JH, Gonzalez M, Gallagher R, Miguel JD, Larson RA, Milone G, Paietta E, Rayon C, Rowe JM, Rivas C, Schiffer CA, Vellenga E, Shepherd L, Slack JL, Wiernik PH, Willman CL, Sanz MA: Does microgranular variant morphology of acute promyelocytic leukemia independently predict a less favorable outcome compared with classical M3 APL? A joint study of the North American Intergroup and the PETHEMA Group. Blood; 2010 Dec 16;116(25):5650-9
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  • [Title] Does microgranular variant morphology of acute promyelocytic leukemia independently predict a less favorable outcome compared with classical M3 APL? A joint study of the North American Intergroup and the PETHEMA Group.
  • Few studies have examined the outcome of large numbers of patients with the microgranular variant (M3V) of acute promyelocytic leukemia (APL) in the all-trans retinoic acid era.
  • Here, the outcome of 155 patients treated with all-trans retinoic acid-based therapy on 3 clinical trials, North American Intergroup protocol I0129 and Programa para el Estudio de la Terapéutica en Hemopatía Maligna protocols LPA96 and LPA99, are reported.
  • The incidence of the APL differentiation syndrome was 26%, compared with 25% for classical M3 patients, and the early death rate was 13.6% compared with 8.4% for patients with classical M3 morphology.
  • When outcomes were adjusted for the white blood cell count or the relapse risk score, none of these outcomes were significantly different between patients with M3V and classical M3 APL.

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  • (PMID = 20858857.001).
  • [ISSN] 1528-0020
  • [Journal-full-title] Blood
  • [ISO-abbreviation] Blood
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA33601; United States / NCI NIH HHS / CA / CA12213; United States / NCI NIH HHS / CA / CA20319; United States / NCI NIH HHS / CA / N01 CA032102; United States / NCI NIH HHS / CA / CA31936; United States / NCI NIH HHS / CA / CA66636; United States / NCI NIH HHS / CA / U10 CA021115; United States / NCI NIH HHS / CA / U10 CA033601; United States / NCI NIH HHS / CA / U10 CA017145; United States / NCI NIH HHS / CA / U10 CA014028; United States / NCI NIH HHS / CA / CA14028; United States / NCI NIH HHS / CA / U10 CA066636; United States / NCI NIH HHS / CA / R01 CA056771; United States / NCI NIH HHS / CA / CA17145; United States / NCI NIH HHS / CA / U10 CA032102; United States / NCI NIH HHS / CA / CA32102; United States / NCI NIH HHS / CA / CA38926; United States / NCI NIH HHS / CA / N01 CA038926; United States / NCI NIH HHS / CA / U10 CA020319; United States / NCI NIH HHS / CA / U10 CA038926; United States / NCI NIH HHS / CA / U10 CA023318; United States / NCI NIH HHS / CA / CA21115; United States / NCI NIH HHS / CA / U24 CA114737; United States / NCI NIH HHS / CA / CA23318; United States / NCI NIH HHS / CA / CA56771
  • [Publication-type] Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 04079A1RDZ / Cytarabine; 5688UTC01R / Tretinoin; ZS7284E0ZP / Daunorubicin
  • [Other-IDs] NLM/ PMC3031411
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43. Cui X, Xu YQ: [Professor XU Rui-Zheng's experience in clinical diagnosis and treatment of auricular acupuncture]. Zhongguo Zhen Jiu; 2008 Jun;28(6):448-50
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  • [Title] [Professor XU Rui-Zheng's experience in clinical diagnosis and treatment of auricular acupuncture].
  • Professor XU Rui-Zheng's experience in clinical diagnosis and treatment of auricular acupuncture are introduced.
  • He is good at using auricular acupuncture to treat various diseases and symptoms, and he has rich experience in treatment of difficult and complicated cases, reflecting both syndrome differentiation treatment and an organic conception of the human body in treatment, with obviously clinical effect.
  • [MeSH-minor] Diagnosis, Differential. Humans

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  • (PMID = 18630546.001).
  • [ISSN] 0255-2930
  • [Journal-full-title] Zhongguo zhen jiu = Chinese acupuncture & moxibustion
  • [ISO-abbreviation] Zhongguo Zhen Jiu
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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44. de la Serna J, Montesinos P, Vellenga E, Rayón C, Parody R, León A, Esteve J, Bergua JM, Milone G, Debén G, Rivas C, González M, Tormo M, Díaz-Mediavilla J, González JD, Negri S, Amutio E, Brunet S, Lowenberg B, Sanz MA: Causes and prognostic factors of remission induction failure in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and idarubicin. Blood; 2008 Apr 1;111(7):3395-402
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  • [Title] Causes and prognostic factors of remission induction failure in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and idarubicin.
  • An understanding of the prognostic factors associated with the various forms of induction mortality in patients with acute promyelocytic leukemia (APL) has remained remarkably limited.
  • This study reports the incidence, time of occurrence, and prognostic factors of the major categories of induction failure in a series of 732 patients of all ages (range, 2-83 years) with newly diagnosed APL who received all-trans retinoic acid (ATRA) plus idarubicin as induction therapy in 2 consecutive studies of the Programa de Estudio y Tratamiento de las Hemopatias Malignas (PETHEMA) Group.
  • Hemorrhage was the most common cause of induction death (5%), followed by infection (2.3%) and differentiation syndrome (1.4%).
  • Multivariate analysis identified specific and distinct pretreatment characteristics to correlate with an increased risk of death caused by hemorrhage (abnormal creatinine level, increased peripheral blast counts, and presence of coagulopathy), infection (age>60 years, male sex, and fever at presentation), and differentiation syndrome (Eastern Cooperative Oncology Group [ECOG] score>1 and low albumin levels), respectively.
  • These data furnish clinically relevant information that might be useful for designing more appropriately risk-adapted treatment protocols aimed at reducing the considerable problem of induction mortality in APL.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / adverse effects. Hemorrhage / mortality. Infection / mortality. Leukemia, Promyelocytic, Acute / mortality
  • [MeSH-minor] Adolescent. Adult. Age Factors. Aged. Aged, 80 and over. Blast Crisis / blood. Blast Crisis / drug therapy. Blast Crisis / mortality. Child. Child, Preschool. Creatinine / blood. Disease-Free Survival. Female. Humans. Idarubicin / administration & dosage. Idarubicin / adverse effects. Male. Middle Aged. Remission Induction. Risk Factors. Sex Factors. Survival Rate. Syndrome. Treatment Failure. Tretinoin / administration & dosage. Tretinoin / adverse effects

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  • (PMID = 18195095.001).
  • [ISSN] 0006-4971
  • [Journal-full-title] Blood
  • [ISO-abbreviation] Blood
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 5688UTC01R / Tretinoin; AYI8EX34EU / Creatinine; ZRP63D75JW / Idarubicin
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45. Cunha De Santis G, Tamarozzi MB, Sousa RB, Moreno SE, Secco D, Garcia AB, Lima AS, Faccioli LH, Falcão RP, Cunha FQ, Rego EM: Adhesion molecules and Differentiation Syndrome: phenotypic and functional analysis of the effect of ATRA, As2O3, phenylbutyrate, and G-CSF in acute promyelocytic leukemia. Haematologica; 2007 Dec;92(12):1615-22
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  • [Title] Adhesion molecules and Differentiation Syndrome: phenotypic and functional analysis of the effect of ATRA, As2O3, phenylbutyrate, and G-CSF in acute promyelocytic leukemia.
  • BACKGROUND AND OBJECTIVES: Differentiation Syndrome (DS) is a treatment complication which can occur in patients treated with acute promyelocytic leukemia (APL) with all transretinoic acid (ATRA) or As(2)O(3), and is characterized by enhanced leukocyte transmigration.
  • DESIGN AND METHODS: APL blasts and NB4 cells were treated with ATRA, As(2)O(3), PB, G-CSF or their association and the expression of adhesion molecules was determined by flow cytometry.
  • RESULTS: In NB4 and APL blasts, ATRA and As(2)O(3) increased CD54 expression, but no synergism was detected.
  • INTERPRETATION AND CONCLUSIONS: The use of As(2)O(3), PB and G-CSF in association with ATRA should not aggravate DS in APL.
  • [MeSH-major] Antigens, CD / biosynthesis. Antineoplastic Agents / pharmacology. Arsenicals / pharmacology. Cell Adhesion Molecules / biosynthesis. Cell Differentiation / drug effects. Granulocyte Colony-Stimulating Factor / pharmacology. Leukemia, Promyelocytic, Acute / metabolism. Neoplasm Proteins / biosynthesis. Oxides / pharmacology. Phenylbutyrates / pharmacology. Tretinoin / pharmacology
  • [MeSH-minor] Animals. Cell Adhesion / drug effects. Cell Adhesion / genetics. Gene Expression Regulation, Leukemic / drug effects. Gene Expression Regulation, Leukemic / genetics. Humans. Mice. Mice, Inbred BALB C. Mice, Knockout. Syndrome. Tumor Cells, Cultured

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  • (PMID = 18055984.001).
  • [ISSN] 1592-8721
  • [Journal-full-title] Haematologica
  • [ISO-abbreviation] Haematologica
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antineoplastic Agents; 0 / Arsenicals; 0 / Cell Adhesion Molecules; 0 / Neoplasm Proteins; 0 / Oxides; 0 / Phenylbutyrates; 143011-72-7 / Granulocyte Colony-Stimulating Factor; 5688UTC01R / Tretinoin; S7V92P67HO / arsenic trioxide
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46. Zhang Q, Liu P, Zhang HW: [Study on the patterns of TCM syndrome differentiation of 900 patients with posthepatitic cirrhosis]. Zhongguo Zhong Xi Yi Jie He Za Zhi; 2006 Aug;26(8):694-7
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  • [Title] [Study on the patterns of TCM syndrome differentiation of 900 patients with posthepatitic cirrhosis].
  • OBJECTIVE: To investigate the formula for TCM syndrome pattern differentiation in patients with posthepatitic cirrhosis.
  • METHODS: Factors analysis, C mean clustering and fuzzy comprehensive assessment were used for analyzing the basic information, including clinical symptoms and signs, obtained from 900 patients with posthepatitic cirrhosis to establish the formula for syndrome pattern differentiation through collecting the syndromic factors.
  • RESULTS: Multivariate statistic analysis showed the syndromic factors could be classified into two categories: the common characteristics related factors, which reflected the basic pathology of cirrhosis as qi deficiency and blood stasis, and the factors for differentiating 5 syndrome patterns (Gan-Shen yin-deficiency, dampness-heat accumulation, stasis-heat accumulation, Gan-qi stagnation with Pi-deficiency, and Pi-Shen qi-deficiency), which reflected the different pathological features of different syndrome patterns, showing the complexity and polymorphism of syndrome construction.
  • And the functional formula for differentiating syndrome pattern was established.
  • CONCLUSION: The differentiating formula of TCM syndrome pattern could provide a quantified criterion for syndrome pattern differentiation in posthepatitic cirrhosis patients.

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  • (PMID = 16970090.001).
  • [ISSN] 1003-5370
  • [Journal-full-title] Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine
  • [ISO-abbreviation] Zhongguo Zhong Xi Yi Jie He Za Zhi
  • [Language] CHI
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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47. Zha QL, He YT, Yu JP: [Correlations between diagnostic information and therapeutic efficacy in rheumatoid arthritis analyzed with decision tree model]. Zhongguo Zhong Xi Yi Jie He Za Zhi; 2006 Oct;26(10):871-6
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  • METHODS: Three hundred and ninety seven patients came from 9 clinical centers were randomly divided into the Western medicine (WM) group (n=194) treated with non-steroidal anti-inflammatory drugs and slow-acting antirheumatic drug and the Chinese medicine (CM) group (n=203) with basic therapy and syndrome-differentiation dependant TCM treatment.
  • CONCLUSION: To analyze the correlations between diagnostic information and therapeutic efficacy with decision tree analysis is conformed to the theory of TCM in applying treatment according to syndrome differentiation individually, thus it would contribute to elevate the accuracy of therapy.

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  • (PMID = 17121034.001).
  • [ISSN] 1003-5370
  • [Journal-full-title] Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine
  • [ISO-abbreviation] Zhongguo Zhong Xi Yi Jie He Za Zhi
  • [Language] CHI
  • [Publication-type] English Abstract; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Diterpenes; 0 / Drugs, Chinese Herbal; 0 / Epoxy Compounds; 0 / Phenanthrenes; 19ALD1S53J / triptolide
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48. Zhang SS, Wang HB, Li ZH: [A multi-center randomized controlled trial on treatment of diarrhea-predominant irritable bowel syndrome by Chinese medicine syndrome-differentiation therapy]. Zhongguo Zhong Xi Yi Jie He Za Zhi; 2010 Jan;30(1):9-12
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  • [Title] [A multi-center randomized controlled trial on treatment of diarrhea-predominant irritable bowel syndrome by Chinese medicine syndrome-differentiation therapy].
  • OBJECTIVE: To verify the clinical efficacy of Chinese Medicine syndrome-differentiation therapy in treating diarrhea-predominant irritable bowel syndrome IBS-D.
  • CONCLUSION: Chinese medicine syndrome-differentiation dependent therapy shows good efficacy in treating IBS-D.

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  • (PMID = 20353023.001).
  • [ISSN] 1003-5370
  • [Journal-full-title] Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine
  • [ISO-abbreviation] Zhongguo Zhong Xi Yi Jie He Za Zhi
  • [Language] CHI
  • [Publication-type] English Abstract; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Drugs, Chinese Herbal
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49. Zou MX: [Treatment of eczema should combine syndrome differentiation with disease]. Zhongguo Zhong Xi Yi Jie He Za Zhi; 2008 Aug;28(8):680-1
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  • [Title] [Treatment of eczema should combine syndrome differentiation with disease].

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  • (PMID = 18928085.001).
  • [ISSN] 1003-5370
  • [Journal-full-title] Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine
  • [ISO-abbreviation] Zhongguo Zhong Xi Yi Jie He Za Zhi
  • [Language] CHI
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Drugs, Chinese Herbal
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50. Ma RW, Zou DJ, Wang QJ: [Effect of compound Danshen Dripping Pill on carotid arterial intima-media in patients with type 2 diabetes mellitus]. Zhongguo Zhong Xi Yi Jie He Za Zhi; 2010 Aug;30(8):833-7
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  • Patients in Group D were subdivided by Chinese medicine syndrome differentiation into four types, 8 of Yin-deficiency with flourishing heat type (YDFH), 5 of both qi-yin deficient type (BQYD), 8 of both yin-yang deficient type (BYYD) and 13 of blood-stasis and qi-stagnant type (BSQS).


51. Zhang XL, Liu Y, Yang LK, Wang L: [Clinical observation on effects of routine acupuncture combined with Feiteng Bafa for chloasma]. Zhongguo Zhen Jiu; 2009 Jun;29(6):455-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Forty cases were randomly divided into a Feiteng Bafa group (FB) and a selecting points based on differentiation of syndromes group (DS), 20 cases in each group and acupoints.
  • Hegu (LI 4), acupoints in close proximity to chloasma and according to differentiation of syndrome were selected in DS group.
  • [MeSH-minor] Adult. Female. Humans. Male. Middle Aged. Syndrome. Treatment Outcome

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  • (PMID = 19563192.001).
  • [ISSN] 0255-2930
  • [Journal-full-title] Zhongguo zhen jiu = Chinese acupuncture & moxibustion
  • [ISO-abbreviation] Zhongguo Zhen Jiu
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Randomized Controlled Trial
  • [Publication-country] China
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52. Chi JF, Niu JZ, Xu SQ, Li J, Wang JF, Liu JP: [Treatment of Alzheimer disease: an evidence-based review]. Zhong Xi Yi Jie He Xue Bao; 2007 May;5(3):247-54
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  • The solution to this would be to improve study quality by strengthening study design and carefully select more homogeneous subjects in terms of syndrome differentiation, by so doing, the results of meta analysis will be more convincing and easily recognized by international society.
  • [MeSH-major] Alzheimer Disease / drug therapy. Drugs, Chinese Herbal / therapeutic use. Evidence-Based Medicine. Phytotherapy
  • [MeSH-minor] Drug Therapy / methods. Humans. Medicine, Chinese Traditional / methods. Randomized Controlled Trials as Topic


53. Sun DZ, Liu L, Jiao JP, Wei PK, Jiang LD, Xu L: Syndrome characteristics of traditional Chinese medicine: summary of a clinical survey in 767 patients with gastric cancer. Zhong Xi Yi Jie He Xue Bao; 2010 Apr;8(4):332-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Syndrome characteristics of traditional Chinese medicine: summary of a clinical survey in 767 patients with gastric cancer.
  • OBJECTIVE: The present study is a summary of syndrome types of gastric cancer in order of priority based on clinical practical situations, routine clinical syndrome differentiation and a large-sample clinical survey in 767 patients with gastric cancer.
  • METHODS: Based on the six-type classification of gastric cancer in a previous study, a bedside syndrome differentiation diagnosis was made simultaneously by two attending doctors of traditional Chinese medicine (TCM to avoid possible diagnostic bias.
  • A clinical differentiation survey form designed under the direction of epidemiologists was filled out by patients with gastric cancer in multiple centers, and the results were digitally valued and statistically analyzed.
  • RESULTS: The symptoms and signs in each syndrome type of gastric cancer were ranked in order of priority as follows: distended pain, stringy pulse, eructation, mood-related pain, susceptibility to anger, acid regurgitation, hiccup, fullness sensation or distension after eating just a little, dizziness, thin pulse, abdominal enlargement, obstruction sensation after eating, moving pain, and uneven pulse in disharmony between liver and stomach;.
  • slender tongue fur, obstruction after eating, slow pulse, moderate pulse, rapid and irregular pulse, normal mood, abdominal pain, diarrhea, cold extremities, lower-extremity edema, cold intolerance, pale complexion, dizziness, emaciation, hiccup, silence, nausea, uneven pulse, acid regurgitation, fullness sensation or distension after eating just a little, vomiting, and constipation in deficiency-cold in spleen and stomach;.
  • uneven pulse, stabbing pain, tortuous sublingual vein, blue or purplish tongue, fixed pain, tarry stool or dark red stool, vomiting of dark red fluid, pale complexion, dry mouth without desire to drink, stringy pulse, white tongue fur, nausea, thin tongue fur, colic pain, hiccup, dizziness, acid regurgitation, bitter taste in mouth, slow pulse, rapid and irregular pulse, thin pulse, and pain relief by pressing in interior retention of toxin stagnation;.
  • CONCLUSION: The summarized syndrome types of gastric cancer from this study are consistent with the clinical situations and would prove to be more referential for TCM syndrome differentiation diagnosis and treatment of gastric cancer.
  • [MeSH-major] Medicine, Chinese Traditional / methods. Stomach Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Young Adult

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  • (PMID = 20388473.001).
  • [ISSN] 1672-1977
  • [Journal-full-title] Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
  • [ISO-abbreviation] Zhong Xi Yi Jie He Xue Bao
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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54. Zhu WF, He JF, Yan JF, Huang BQ: [Algorithm of double levels of frequency and weight to determine the weight value for syndrome factor differentiation]. Zhong Xi Yi Jie He Xue Bao; 2007 Nov;5(6):607-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Algorithm of double levels of frequency and weight to determine the weight value for syndrome factor differentiation].
  • Differentiating syndrome factor and forming syndrome type according to symptoms and signs are the rules and processes of syndrome differentiation in traditional Chinese medicine (TCM).
  • TCM syndrome differentiation is a nonlinear complex giant system.
  • In order to solve the key problem of determination of diagnosing weight value for syndrome factor differentiation, a new algorithm of double levels of frequency and weight based on the analysis of frequency statistics was applied, and the accurate syndrome differentiation parameters were acquired.
  • Therefore, based on the nonlinear and multivariate analysis, a new algorithm of calculating diagnostics for syndrome factor differentiation was established.
  • [MeSH-major] Algorithms. Diagnosis, Differential. Medicine, Chinese Traditional / methods
  • [MeSH-minor] Humans. Multivariate Analysis. Syndrome

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  • (PMID = 17997931.001).
  • [ISSN] 1672-1977
  • [Journal-full-title] Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
  • [ISO-abbreviation] Zhong Xi Yi Jie He Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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55. Chen ZQ, Lu LG: [Integral syndrome differentiation, local syndrome differentiation and microcosmic syndrome differentiation --thinking on the modern TCM system of syndrome differentiation dependent treatment]. Zhongguo Zhong Xi Yi Jie He Za Zhi; 2006 Dec;26(12):1126-7
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  • [Title] [Integral syndrome differentiation, local syndrome differentiation and microcosmic syndrome differentiation --thinking on the modern TCM system of syndrome differentiation dependent treatment].
  • From the historic and realistic viewpoints, the authors discussed the theory of TCM syndrome differentiation, pointing out that the modern TCM system of syndrome differentiation dependent treatment should consist of three components, the integral syndrome differentiation, local syndrome differentiation and microcosmic syndrome differentiation, they are independent comparatively and supplementary with each other.

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  • (PMID = 17205829.001).
  • [ISSN] 1003-5370
  • [Journal-full-title] Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine
  • [ISO-abbreviation] Zhongguo Zhong Xi Yi Jie He Za Zhi
  • [Language] CHI
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Drugs, Chinese Herbal
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56. Chu YG, Shi J, Hu YH: [Serum proteomic study on hypertension patients with Gan-Dan damp-heat syndrome]. Zhongguo Zhong Xi Yi Jie He Za Zhi; 2010 Jan;30(1):37-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Serum proteomic study on hypertension patients with Gan-Dan damp-heat syndrome].
  • OBJECTIVE: To study the serum proteomics in hypertension patients with Gan-Dan damp-heat syndrome (GDDH) for tentatively find special proteins associated with the syndrome.
  • In the patients enrolled, 40 were differentiated as GDDH syndrome and the other 20 as non-GDDH syndrome.
  • After all the proteomic fingerprints being analyzed by Biomarker Wizard 3.1, the special expressed proteins for GDDH syndrome were identified by Biomarker Patterns Software 5.0 to create the syndrome decision model.
  • A decision model consisted 5 screened out protein peaks with mass-to-charge ratio of 2761.555, 6624.362, 2487.192, 2461.610 and 2744.318 was created, which could well differentiate the GDDH syndrome, with the sensitivity of 96.55%, specificity of 90%, false positive rate of 10% and false negative rate of 3.45%.
  • CONCLUSION: The differently expressed protein is the material foundation of GDDH syndrome; molecular biological decision model established on the basis of this foundation can offer a tool for making Chinese medicine syndrome differentiation more objectively and accurately.

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  • (PMID = 20353030.001).
  • [ISSN] 1003-5370
  • [Journal-full-title] Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine
  • [ISO-abbreviation] Zhongguo Zhong Xi Yi Jie He Za Zhi
  • [Language] CHI
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Blood Proteins; 0 / Proteome
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57. Jiang M: The TCM stage-oriented treatment for chronic cardiac insufficiency. J Tradit Chin Med; 2007 Mar;27(1):49-54
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  • At the acute aggravation stage of cardiac insufficiency, the inducing factors should be first eliminated to control the condition as soon as possible; and at the critical moment, modern medicine should be used.
  • In case of acute pulmonary edema, emergency treatment should be given to save the patient's life.
  • When the acute pulmonary edema is alleviated, Chinese drugs can be used, based on the TCM syndrome differentiation, mainly for removing the pathogenic fluid retention, and restoring the heart-qi and heart-yang.

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  • (PMID = 17393628.001).
  • [ISSN] 0255-2922
  • [Journal-full-title] Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan
  • [ISO-abbreviation] J Tradit Chin Med
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Cardiotonic Agents; 0 / Diuretics; 0 / Drugs, Chinese Herbal
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58. Mathieu J, Giraudier S, Lanotte M, Besançon F: Retinoid-induced activation of NF-kappaB in APL cells is not essential for granulocytic differentiation, but prolongs the life span of mature cells. Oncogene; 2005 Nov 3;24(48):7145-55
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  • [Title] Retinoid-induced activation of NF-kappaB in APL cells is not essential for granulocytic differentiation, but prolongs the life span of mature cells.
  • All-trans retinoic acid (ATRA) significantly improves the survival of patients with acute promyelocytic leukemia (APL) by inducing granulocytic differentiation of leukemia cells.
  • Since an activation of the transcription factor NF-kappaB occurs during ATRA-induced maturation of APL cells, a mechanistic link between these two processes was investigated.
  • Using an in vitro model for APL, we report that ectopic overexpression of a repressor of NF-kappaB activation did not affect granulocytic differentiation.
  • Altogether, our results demonstrate an anti-apoptotic effect of NF-kappaB activation during ATRA-induced differentiation of NB4 cells and identify repression of ROS-mediated JNK activation as a mechanism for this effect.
  • Our observations also suggest that NF-kappaB signalling may contribute to an accumulation of mature APL cells and participate in the development of ATRA syndrome.
  • [MeSH-major] Cell Aging / drug effects. Cell Differentiation / drug effects. Granulocytes / physiology. Leukemia, Promyelocytic, Acute / pathology. NF-kappa B / metabolism. Tretinoin / pharmacology
  • [MeSH-minor] Antigens, CD11c / metabolism. Antioxidants / pharmacology. Apoptosis / drug effects. Blotting, Western. Butylated Hydroxyanisole / pharmacology. Cell Line, Tumor. Cell Survival / drug effects. Electrophoresis, Polyacrylamide Gel. Enzyme Activation / drug effects. Flow Cytometry. Fluorescent Antibody Technique, Direct. Gene Expression Regulation, Leukemic / drug effects. Humans. JNK Mitogen-Activated Protein Kinases / metabolism. Reactive Oxygen Species / metabolism. Retroviridae / genetics. Spectrometry, X-Ray Emission

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  • [Copyright] Oncogene (2005) 24, 7145-7155. doi:10.1038/sj.onc.1208889; published online 25 July 2005.
  • (PMID = 16044154.001).
  • [ISSN] 0950-9232
  • [Journal-full-title] Oncogene
  • [ISO-abbreviation] Oncogene
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD11c; 0 / Antioxidants; 0 / NF-kappa B; 0 / Reactive Oxygen Species; 25013-16-5 / Butylated Hydroxyanisole; 5688UTC01R / Tretinoin; EC 2.7.11.24 / JNK Mitogen-Activated Protein Kinases
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59. Patatanian E, Thompson DF: Retinoic acid syndrome: a review. J Clin Pharm Ther; 2008 Aug;33(4):331-8
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  • [Title] Retinoic acid syndrome: a review.
  • The retinoic acid syndrome (RAS) is an unpredictable but frequent complication which may develop after administration of all-trans retinoic acid (ATRA) most commonly in patients with acute promyelocytic leukaemia (APL).
  • In this review, we describe the incidence, predictive factors, clinical course, outcome and treatment of RAS in patients with APL treated with ATRA.
  • Liposomal ATRA is being investigated to induce haematological cure in APL without chemotherapy and to reduce the incidence of RAS but further validation of its usefulness is necessary.
  • [MeSH-major] Antineoplastic Agents / adverse effects. Leukemia, Promyelocytic, Acute / drug therapy. Tretinoin / adverse effects
  • [MeSH-minor] Antigens, CD13. Antineoplastic Combined Chemotherapy Protocols / adverse effects. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Gene Expression Regulation, Neoplastic. Glucocorticoids / therapeutic use. Humans. Incidence. Leukocyte Count. Syndrome

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  • (PMID = 18613850.001).
  • [ISSN] 1365-2710
  • [Journal-full-title] Journal of clinical pharmacy and therapeutics
  • [ISO-abbreviation] J Clin Pharm Ther
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Glucocorticoids; 5688UTC01R / Tretinoin; EC 3.4.11.2 / Antigens, CD13
  • [Number-of-references] 42
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60. Wang QC: [Research direction for syndromes of traditional Chinese medicine: differentiating diseases from syndromes and differentiating syndromes from diseases]. Zhong Xi Yi Jie He Xue Bao; 2006 May;4(3):221-4
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  • By historical review on integrative research of syndrome differentiation and disease differentiation and considering the scientific research method of traditional Chinese medicine (TCM), the syndrome is the key subject of clinical study on TCM.
  • During the recent 10 years or more, many new diseases and diagnostic approaches have been found and developed in Western medicine, while in TCM, the advances in research on syndrome can not keep up with the requirements of clinical practice.
  • (1) Syndrome differentiation and its classification have been conservative and lack of new discovery;.
  • (2) The thinking pattern of clinical practice has been focused on disease differentiation, and only complemented by syndrome differentiation;.
  • (3) The treatment has been concentrated on the disease instead of on the syndrome.
  • In this way, many new syndromes and diseases will be discovered with the improvement of disease and syndrome differentiations.
  • [MeSH-major] Diagnosis, Differential. Medicine, Chinese Traditional / trends

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  • (PMID = 16696905.001).
  • [ISSN] 1672-1977
  • [Journal-full-title] Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
  • [ISO-abbreviation] Zhong Xi Yi Jie He Xue Bao
  • [Language] chi
  • [Publication-type] Editorial; English Abstract
  • [Publication-country] China
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61. Zhao BX: [On acupuncture and moxibustion treatment based on the layers of "skin, vessel, muscle, tendon and bone"]. Zhongguo Zhen Jiu; 2005 Jun;25(6):433-5
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  • CONCLUSION: The treatment based on layers of "skin, vessel, muscle, tendon and bone" is of important significance for recognition of acupuncture values in The Yellow Emperor's Internal Classic, a new establishment of diagnosis and examination, syndrome differentiation, treatment system of acupuncture and moxibustion independent of drug prescription, enriching acupuncture and moxibustion therapy, increasing the therapeutic effect of acupuncture and moxibustion, and extending the range of acupuncture and moxibustion treatment.

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  • (PMID = 16309091.001).
  • [ISSN] 0255-2930
  • [Journal-full-title] Zhongguo zhen jiu = Chinese acupuncture & moxibustion
  • [ISO-abbreviation] Zhongguo Zhen Jiu
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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62. Suzukawa M, Nakazora T, Kawasaki Y, Tominaga T, Shinohara K: Massive ascites associated with all-trans retinoic acid treatment in therapy-related acute promyelocytic leukemia. Intern Med; 2010;49(5):457-60
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  • [Title] Massive ascites associated with all-trans retinoic acid treatment in therapy-related acute promyelocytic leukemia.
  • Cytogenetic analysis demonstrated del(7), t(15;17)(q22;q12), and a fluorescence in-situ hybridization (FISH) study demonstrated chimeric fusion genes of PML-RAR-alpha.
  • He was diagnosed with therapy-related acute promyelocytic leukemia (APL), and treated with all trans-retinoic acid (ATRA).
  • He showed the progressive accumulation of ascites with liver damage, without pulmonary symptoms of ATRA differentiation syndrome.
  • [MeSH-major] Ascites / chemically induced. Ascites / diagnosis. Chemoembolization, Therapeutic / adverse effects. Leukemia, Promyelocytic, Acute / drug therapy. Leukemia, Promyelocytic, Acute / etiology. Tretinoin / adverse effects. Tretinoin / therapeutic use

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  • (PMID = 20190483.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Antineoplastic Agents; 3Z8479ZZ5X / Epirubicin; 5688UTC01R / Tretinoin
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63. Lin JC, Li HK, Zhou MM, Jia W: [Metabonomics, pharmaco-metabonomics, and the modernization of traditional Chinese medicine]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao; 2007 Dec;29(6):818-22
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  • The application of metabonomics and pharmaco-metabonomics in the modernization of TCM will deepen the evaluation of the therapeutic effects of TCM, the study of intrinsic quality of TCM syndrome and the treatment by differentiation of syndrome, facilitate the integration of TCM with modern biological science and technology, promote the modernization of TCM, and provide a new space for the development of TCM.

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  • (PMID = 18595265.001).
  • [ISSN] 1000-503X
  • [Journal-full-title] Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
  • [ISO-abbreviation] Zhongguo Yi Xue Ke Xue Yuan Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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64. Lu AP, Chen KJ: [Pondering on syndrome differentiation of diseases]. Zhongguo Zhong Xi Yi Jie He Za Zhi; 2005 Sep;25(9):843-5
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  • [Title] [Pondering on syndrome differentiation of diseases].
  • The disease classification in Western medicine and syndrome differentiation in traditional Chinese medicine were comparatively analyzed in this paper.
  • It is proposed that the research on syndrome differentiation of disease classification is one of the cut-in points in integrative medicine research, and indicated that the research may be deepened by way of TCM syndrome classification based on diagnosis and on therapeutic efficacy.

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  • (PMID = 16248253.001).
  • [ISSN] 1003-5370
  • [Journal-full-title] Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine
  • [ISO-abbreviation] Zhongguo Zhong Xi Yi Jie He Za Zhi
  • [Language] CHI
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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65. Gupta V, Yi QL, Brandwein J, Lipton JH, Messner HA, Schuh AC, Wells RA, Minden MD: Role of all-trans-retinoic acid (ATRA) in the consolidation therapy of acute promyelocytic leukaemia (APL). Leuk Res; 2005 Jan;29(1):113-4
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  • [Title] Role of all-trans-retinoic acid (ATRA) in the consolidation therapy of acute promyelocytic leukaemia (APL).
  • The role of all-trans-retinoic acid (ATRA) in the consolidation therapy of acute promyelocytic leukaemia (APL) is undefined at present.
  • Between 1994 and 1999, we treated 38 newly diagnosed APL patients with ATRA and chemotherapy during the induction and consolidation.
  • ATRA was well-tolerated during consolidation therapy with no cases of retinoic acid syndrome.
  • The 5-year overall and leukaemia-free survival of study patients was 82% (95% C.I.
  • The role of ATRA during consolidation therapy of APL merits further investigation as this may allow shortening the overall duration of APL treatment.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Leukemia, Promyelocytic, Acute / drug therapy. Tretinoin / administration & dosage
  • [MeSH-minor] Adolescent. Adult. Aged. Drug Administration Schedule. Female. Humans. Male. Middle Aged. Remission Induction. Survival Rate

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  • (PMID = 15541484.001).
  • [ISSN] 0145-2126
  • [Journal-full-title] Leukemia research
  • [ISO-abbreviation] Leuk. Res.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 5688UTC01R / Tretinoin
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66. Shen ZY: [Studies of gene networks and singal transduction of kidney deficiency syndrome by syndrome differentiation through drug effects]. Zhongguo Zhong Xi Yi Jie He Za Zhi; 2005 Dec;25(12):1125-8
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  • [Title] [Studies of gene networks and singal transduction of kidney deficiency syndrome by syndrome differentiation through drug effects].
  • The hypothesis was expressed that the "disease" or "syndrome" formed in the human body by the intervention from outside world is based on the changes of multi-molecular network.
  • In this paper, the pattern and ability of signal transduction channel and the methods of studying changes in it were also described, and raised, herefrom, "to determine syndrome by drug effects (DSDE)" is the intervention means for studying syndrome in the light of systemic biological methods.
  • We found Kidney-yang deficiency syndrome covered the NEI network and the regulating center located in hypothamus with Compound Bushen Recipe (CBR, Kidney-tonifying recipe).
  • For example, in the network mechanism of lymphocyte apoptosis and proliferation, EF can reconstruct the balance of the opposite apoptosis related genes and proliferation related genes; EF can assemble and integrate co-stimulating molecules, transform growth factors (TGF), and several oncogenes to form an upstream factor network for initiating the proliferation and anti-apoptosis promotion; EF can simultaneously up-regulate the two opposite genes expression of IkappaB and NFkappaB in NIK/IKK/IkappaB/Rel/NFkappaB signal transduction channel, which could not only control the rising of NFkappaB in a moderate range, but also guarantee its predominant status to exert its hinge role in molecule regulating network, by which gene network regulation atlas in HPAT axis of Kidney-deficiency syndrome was observed.

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  • (PMID = 16398438.001).
  • [ISSN] 1003-5370
  • [Journal-full-title] Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine
  • [ISO-abbreviation] Zhongguo Zhong Xi Yi Jie He Za Zhi
  • [Language] CHI
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Drugs, Chinese Herbal
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67. Chen WG, Ba ZM: Prof. ZHANG Yi's experience in treating severe arrhythmia. J Tradit Chin Med; 2010 Mar;30(1):47-50
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  • Decoction of prepared Licorice) is made for the syndrome of both yin and yang deficiency of the Heart, with the effects of tonifying yin and nourishing blood, activating yang and restoring normal pulse, and evenly tonifying yin and yang.
  • The heart rate may be slow or fast; and the symptoms may belong to the cold or heat, excess or deficiency syndrome.
  • Therefore, the treatment should be based on syndrome-differentiation.

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  • (PMID = 20397463.001).
  • [ISSN] 0255-2922
  • [Journal-full-title] Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan
  • [ISO-abbreviation] J Tradit Chin Med
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Drugs, Chinese Herbal
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68. Liu JP: [Design and application of single case randomized controlled trial]. Zhongguo Zhong Xi Yi Jie He Za Zhi; 2005 Mar;25(3):252-4
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  • Traditional Chinese medicine is good at treatment of chronic disease, Syndrome differentiation, the traits of TCM, requires multiple research methods.

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  • (PMID = 15842150.001).
  • [ISSN] 1003-5370
  • [Journal-full-title] Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine
  • [ISO-abbreviation] Zhongguo Zhong Xi Yi Jie He Za Zhi
  • [Language] CHI
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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69. Wang SQ: Treating biliary system postoperational complications by syndrome differentiation using traditional Chinese medicine. Chin J Integr Med; 2007 Dec;13(4):249-50
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  • [Title] Treating biliary system postoperational complications by syndrome differentiation using traditional Chinese medicine.
  • [MeSH-major] Biliary Tract Diseases / diagnosis. Biliary Tract Diseases / therapy. Biliary Tract Surgical Procedures / adverse effects. Medicine, Chinese Traditional / methods. Postoperative Complications / diagnosis. Postoperative Complications / therapy
  • [MeSH-minor] Cholestasis / diagnosis. Diagnosis, Differential. Gallbladder / pathology. Gallbladder Diseases / diagnosis. Hot Temperature. Humans. Liver / pathology. Syndrome

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  • (PMID = 18180886.001).
  • [ISSN] 1672-0415
  • [Journal-full-title] Chinese journal of integrative medicine
  • [ISO-abbreviation] Chin J Integr Med
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 0
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70. Liu QG: [Brief introduction of professor Yang Jia-san's academic thought]. Zhongguo Zhen Jiu; 2008 May;28(5):359-64
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  • The present paper introduces Prof. YANG's academic thought from acupoint theory, acupoint selection method, filiform needle needling methods, reinforcing and reducing manipulation, clinical acupoint association, syndrome differentiation treatment thought, etc.
  • YANG's syndrome differentiation treatment thought includes following 3 characteristics:.
  • (1) reflecting the spirit of special recipe, special drug and special acupoint for special disease;.
  • (2) being good at combined acupuncture and drug;.

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  • (PMID = 18652330.001).
  • [ISSN] 0255-2930
  • [Journal-full-title] Zhongguo zhen jiu = Chinese acupuncture & moxibustion
  • [ISO-abbreviation] Zhongguo Zhen Jiu
  • [Language] chi
  • [Publication-type] Biography; English Abstract; Historical Article; Journal Article
  • [Publication-country] China
  • [Personal-name-as-subject] Yang JS
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71. Mao JY: [Key points of traditional Chinese medicine syndrome differentiation therapy on heart failure]. Zhongguo Zhong Xi Yi Jie He Za Zhi; 2008 Dec;28(12):1063-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Key points of traditional Chinese medicine syndrome differentiation therapy on heart failure].

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  • (PMID = 19317155.001).
  • [ISSN] 1003-5370
  • [Journal-full-title] Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine
  • [ISO-abbreviation] Zhongguo Zhong Xi Yi Jie He Za Zhi
  • [Language] CHI
  • [Publication-type] Journal Article
  • [Publication-country] China
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72. Xu K, Luo HY, Li LN: [Clinical study on comprehensive treatment of primary liver cancer mainly with chinese medicinal perfusion/embolization]. Zhongguo Zhong Xi Yi Jie He Za Zhi; 2005 Apr;25(4):299-302
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  • OBJECTIVE: To study the clinical efficacy and adverse reaction of comprehensive therapy mainly with Chinese anti-cancer medicinal perfusion/embolization and assisted with Chinese drug-therapy based on TCM Syndrome Differentiation in treating primary liver cancer.
  • Besides, both groups were given Chinese herbs according to TCM Syndrome Differentiation additionally.

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  • (PMID = 15892270.001).
  • [ISSN] 1003-5370
  • [Journal-full-title] Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine
  • [ISO-abbreviation] Zhongguo Zhong Xi Yi Jie He Za Zhi
  • [Language] CHI
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; 0 / Drugs, Chinese Herbal
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73. Yang D, Hladnik L: Treatment of acute promyelocytic leukemia during pregnancy. Pharmacotherapy; 2009 Jun;29(6):709-24
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  • [Title] Treatment of acute promyelocytic leukemia during pregnancy.
  • Management of the pregnant patient with acute promyelocytic leukemia (APL) is a challenge.
  • Immediate treatment of APL is critical, as it is an oncologic emergency, with a high risk of morbidity and mortality associated with disseminated intravascular coagulation.
  • In addition, complications associated with APL, including retinoic acid syndrome, add to the complexity of management.
  • To better understand how to manage this complex patient care situation, we searched the PubMed database (January 1972-May 2008) for English-language articles about maternal and fetal outcomes resulting from APL treatment during pregnancy.
  • The most commonly administered agents were all-trans-retinoic acid (ATRA), anthracyclines, and antimetabolites.
  • The overall treatment of the pregnant patient with APL should include a discussion about pregnancy termination, especially if APL is diagnosed in the first trimester.
  • Frequent fetal monitoring, along with aggressive management of potential APL-related complications, is necessary to allow for optimal maternal and fetal outcomes.
  • [MeSH-major] Antineoplastic Agents / administration & dosage. Leukemia, Promyelocytic, Acute / drug therapy. Pregnancy Complications, Neoplastic / drug therapy. Tretinoin / administration & dosage
  • [MeSH-minor] Abnormalities, Drug-Induced / etiology. Abortion, Therapeutic. Female. Humans. Pregnancy. Pregnancy Complications, Hematologic / drug therapy. Pregnancy Complications, Hematologic / physiopathology. Pregnancy Outcome


74. Song JN, Liu JL, Fang XZ, Hu YH, Lei Y, Niu XH, Wu G, Chen BS, Ma YL, Chen B, Jin H: [Relationship between plasma protein expression profiles and states of Zang-Fu organs in patients with phlegm or blood stagnation syndromes due to hyperlipidemia and atherosclerosis]. Zhong Xi Yi Jie He Xue Bao; 2008 Dec;6(12):1233-7
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  • METHODS: The states of Zang-Fu organs in 146 patients with hyperlipidemia and atherosclerosis were diagnosed by syndrome differentiation of traditional Chinese medicine.
  • The plasma proteins from these patients were separated by two-dimensional polyacrylamide gel electrophoresis (2-DE).
  • RESULTS: The biomarker proteins such as fibrinogen gamma chain, albumin and apolipoprotein AI (precursor) in discrimination of the patients with phlegm syndrome from phlegm accumulating with stagnation syndrome were correlated with the deficiency of kidney-qi, heart-qi and spleen-qi.
  • Among the four biomarker proteins in discrimination of the patients with phlegm syndrome from blood stagnation syndrome, albumin, adrenomedullin binding protein (precursor) and haptoglobin (precursor) were correlated with the deficiency of kidney-qi and heart-qi, but complement component C4 was independent of the deficient Zang-Fu organs.
  • The biomarker albumin was associated with the deficiency of kidney-qi, heart-qi and spleen-qi, and adrenomedullin binding protein (precursor) was correlated with the deficiency of spleen-qi in discrimination of the patients with blood stagnation syndrome from phlegm accumulating with stagnation syndrome.
  • As the potential biomarker proteins in discrimination of the patients with non-phlegm and non-stagnation syndrome from phlegm accumulating with stagnation syndrome, the fibrinogen beta chain was related with the deficiency of kidney-qi, and apolipoprotein AI (precursor) was correlated with both the deficiency of kidney-qi and heart-qi.
  • [MeSH-minor] Adult. Blood Proteins / metabolism. Female. Humans. Male. Medicine, Chinese Traditional / methods. Middle Aged. Yang Deficiency / blood. Yang Deficiency / diagnosis. Yang Deficiency / physiopathology. Yin Deficiency / blood. Yin Deficiency / diagnosis. Yin Deficiency / physiopathology

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  • (PMID = 19063835.001).
  • [ISSN] 1672-1977
  • [Journal-full-title] Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
  • [ISO-abbreviation] Zhong Xi Yi Jie He Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Blood Proteins; 0 / Proteome
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75. Tang Y, Zheng LJ, Yin LL: [Clinical study on professor Wu Lian-zhong's experience in acupuncture treatment for facial paralysis]. Zhongguo Zhen Jiu; 2009 Aug;29(8):643-4
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  • Professor WU emphasizes the treatment based on syndrome differentiation.
  • The concrete methods of prognosis diagnosis for facial paralysis and three effective cases are introduced.

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  • (PMID = 19947270.001).
  • [ISSN] 0255-2930
  • [Journal-full-title] Zhongguo zhen jiu = Chinese acupuncture & moxibustion
  • [ISO-abbreviation] Zhongguo Zhen Jiu
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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76. Lai SL, Yang XB, Wen ZH: [Exploration on the basic framework of standard for macrocosmic diagnosis of syndrome]. Zhongguo Zhong Xi Yi Jie He Za Zhi; 2005 Jun;25(6):552-5
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  • [Title] [Exploration on the basic framework of standard for macrocosmic diagnosis of syndrome].
  • Starting from the thinking characteristics of TCM in the holistic approach of syndrome and process of syndrome differentiation, the problems in the criteria of syndrome diagnosis was analyzed, combining with the outcome of investigation on macrocosmic diagnosis of syndrome carried on twice by expert group nationwide in China, a concept for designing basic framework of standard for macrocosmic diagnosis of syndrome was advocated in this study.
  • In order to recognize and master fully the standard, the following items would be the contents of the framework: give a standardized term of each syndrome; the basic clinical features of a syndrome; the qualitative parameters which could be used to distinguish the nature of a syndrome, and indexes to be used to judge the affected location of a syndrome during identifying process for a syndrome; the order of pertinent indexes with their given score, and the threshold for quantitative diagnosis.
  • It may enable the syndrome differentiation to access the real world of a patient to be used appropriately this framework.

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  • (PMID = 16025974.001).
  • [ISSN] 1003-5370
  • [Journal-full-title] Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine
  • [ISO-abbreviation] Zhongguo Zhong Xi Yi Jie He Za Zhi
  • [Language] CHI
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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77. Tang Q, Fang YF, Wang B, Wan P: [TCM differentiation and treatment of fibromyalgia syndromes based on meridian science]. Zhongguo Zhen Jiu; 2008 Oct;28(10):761-3
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  • [Title] [TCM differentiation and treatment of fibromyalgia syndromes based on meridian science].
  • Fibromyalgia syndrome (FS) is a rheumatic and immunologic disease and the disease incidence is ranked at the third in the rheumatic diseases, characterized by whole-body myalgia, and with mental and nervous symptoms and signs.
  • Based on TCM theories, this article tries to analyze the pathogenesis of FS from the angle of meridian and collateral science, and according to location of pain of the patient, TCM syndrome differentiation for corresponding channels and collaterals is made and FS possible relation with dysfunction of qi is raised, which is used to guide the treatment, so as to provide a better physical treatment way.
  • [MeSH-minor] Diagnosis, Differential. Humans

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  • (PMID = 18972737.001).
  • [ISSN] 0255-2930
  • [Journal-full-title] Zhongguo zhen jiu = Chinese acupuncture & moxibustion
  • [ISO-abbreviation] Zhongguo Zhen Jiu
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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78. Tsai WH, Hsu HC, Lin CC, Ho CK, Kou YR: Role of interleukin-8 and growth-regulated oncogene-alpha in the chemotactic migration of all-trans retinoic acid-treated promyelocytic leukemic cells toward alveolar epithelial cells. Crit Care Med; 2007 Mar;35(3):879-85
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Role of interleukin-8 and growth-regulated oncogene-alpha in the chemotactic migration of all-trans retinoic acid-treated promyelocytic leukemic cells toward alveolar epithelial cells.
  • OBJECTIVE: Although all-trans retinoic acid (ATRA) can treat acute promyelocytic leukemia (APL), it also causes retinoic acid syndrome with presentations similar to acute respiratory distress syndrome.
  • We investigated the role of interleukin (IL)-8 and growth-regulated oncogene (GRO)-alpha in the chemotactic transmigration of ATRA-treated NB4 (ATRA-NB4) APL cells toward A549 alveolar epithelial cells.
  • CONCLUSIONS: IL-8 and GRO-alpha secreted from alveolar epithelial cells play an important role in the cell-cell interaction involved in the chemotactic transmigration of ATRA-treated APL cells toward alveolar epithelial cells.
  • [MeSH-major] Antineoplastic Agents / toxicity. Chemokines, CXC / physiology. Chemotaxis, Leukocyte / drug effects. Interleukin-8 / physiology. Leukemia, Promyelocytic, Acute / drug therapy. Pulmonary Alveoli / drug effects. Respiratory Distress Syndrome, Adult / chemically induced. Tretinoin / toxicity
  • [MeSH-minor] Cell Line, Tumor. Cell Movement / drug effects. Chemokine CXCL1. Epithelial Cells / drug effects. Epithelial Cells / immunology. Flow Cytometry. Humans. In Vitro Techniques

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  • [CommentIn] Crit Care Med. 2007 Mar;35(3):974-5 [17421102.001]
  • (PMID = 17235257.001).
  • [ISSN] 0090-3493
  • [Journal-full-title] Critical care medicine
  • [ISO-abbreviation] Crit. Care Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / CXCL1 protein, human; 0 / Chemokine CXCL1; 0 / Chemokines, CXC; 0 / Interleukin-8; 5688UTC01R / Tretinoin
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79. Velisavljev-Filipović G: [Arthrogryposis multiplex congenita--a rare congenital stiff joints syndrome]. Med Pregl; 2006 Jul-Aug;59(7-8):375-9
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  • [Title] [Arthrogryposis multiplex congenita--a rare congenital stiff joints syndrome].
  • This rare syndrome is present at birth and is characterized by reduced mobility of many joints.
  • The cause of this syndrome is unknown.
  • DISCUSSION AND CONCLUSION: This is a case report of a "stiff joint syndrome".
  • Due to the fact that data from the family history were unavailable, we could not establish the type of syndrome.
  • However, heredity, growth and development at later age, as well as IQ, might significantly help in definite differentiation of this syndrome.
  • [MeSH-major] Arthrogryposis / diagnosis
  • [MeSH-minor] Humans. Infant, Newborn. Joints / pathology. Syndrome

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  • (PMID = 17140040.001).
  • [ISSN] 0025-8105
  • [Journal-full-title] Medicinski pregled
  • [ISO-abbreviation] Med. Pregl.
  • [Language] srp
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Serbia and Montenegro
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80. Chu YG, Shi J, Hu YH, Wu HQ, Liu GJ, Hu CJ, Li YZ, Li Y, Chen ZJ, He Q: Serum proteomes of hypertension patients with abundant phlegm-dampness. Zhong Xi Yi Jie He Xue Bao; 2009 Jul;7(7):629-35
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  • OBJECTIVE: To study the serum proteomes of essential hypertension (EH) patients with abundant phlegm-dampness, and try to find special proteins associated with abundant phlegm-dampness syndrome.
  • METHODS: Fifty-nine hypertension patients were included, and the patients were divided into abundant phlegm-dampness syndrome group (39 cases) and non-phlegm-dampness syndrome group (20 cases).
  • They could be used to separate the abundant phlegm-dampness syndrome from the healthy persons and the hypertension patients with non-phlegm-dampness.
  • The molecular biology diagnosis model can offer an objective and accurate way for TCM syndrome differentiation.
  • [MeSH-major] Blood Proteins / analysis. Diagnosis, Differential. Hypertension / blood. Medicine, Chinese Traditional. Proteome / metabolism

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  • (PMID = 19615316.001).
  • [ISSN] 1672-1977
  • [Journal-full-title] Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
  • [ISO-abbreviation] Zhong Xi Yi Jie He Xue Bao
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Blood Proteins; 0 / Proteome
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81. Liu LG, Gu-Jie: [Fan Yu-qi and "Taiyi miraculous moxa roll"]. Zhongguo Zhen Jiu; 2007 Jul;27(7):543-4
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  • CONCLUSION: The "Taiyi miraculous moxa roll" method substitutes moxibustion for acupuncture, with very wide ranges of indications, the most being the thoracico-abdominal diseases, the next being the diseases in the head, and the less being in the limbs and in the lumbodorsal position; so far as the syndrome differentiation is concerned, the most is deficiency syndrome, the next is cold syndrome, wind syndrome, heat syndrome, phlegm syndrome and so on.

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  • (PMID = 17722839.001).
  • [ISSN] 0255-2930
  • [Journal-full-title] Zhongguo zhen jiu = Chinese acupuncture & moxibustion
  • [ISO-abbreviation] Zhongguo Zhen Jiu
  • [Language] chi
  • [Publication-type] English Abstract; Historical Article; Journal Article
  • [Publication-country] China
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82. Wang HM: [Study on rules of distribution field of channels and collaterals]. Zhongguo Zhen Jiu; 2006 Jan;26(1):29-32
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  • CONCLUSION: The study on rules of distribution field of channels and collaterals can guide treatment based on syndrome differentiation, and promote development of theories of channels and collaterals.

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  • (PMID = 16491755.001).
  • [ISSN] 0255-2930
  • [Journal-full-title] Zhongguo zhen jiu = Chinese acupuncture & moxibustion
  • [ISO-abbreviation] Zhongguo Zhen Jiu
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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83. Li YH, Liu HH, Zhang LF: [Current situation of research and problems in diagnosis and treatment of senile depression with integrative traditional Chinese and Western medicine]. Zhongguo Zhong Xi Yi Jie He Za Zhi; 2006 Mar;26(3):281-4
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  • [Title] [Current situation of research and problems in diagnosis and treatment of senile depression with integrative traditional Chinese and Western medicine].
  • This paper summarized the researches on diagnosis and treatment of senile depression with integrative Chinese and Western medicine in the recent 5 years, and some problems existed at present were also submitted.
  • It is pointed out that it's necessary to expand the study with senior electrocerebral neurotransmitter analysis technique (SET) for the diagnosis and efficacy evaluation of senile depression by either traditional Chinese or Western medicine.
  • By which it would also be able to offer convincing evidence for diagnosis of depression, TCM syndrome differentiation dependant therapy and the efficacy evaluation.

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  • (PMID = 16613281.001).
  • [ISSN] 1003-5370
  • [Journal-full-title] Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine
  • [ISO-abbreviation] Zhongguo Zhong Xi Yi Jie He Za Zhi
  • [Language] CHI
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antidepressive Agents; 0 / Drugs, Chinese Herbal
  • [Number-of-references] 20
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84. Jiao L, Wang SJ, Zhuang JL, Zhao YQ, Zhou DB, Xu Y, Han B, Zhang W, Duan MH, Zou N, Zhu TN, Shen T: [Comparison of efficacy and adverse effects between arsenic trioxide and all-trans retinoic acid in patients with acute promyelocytic leukemia]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao; 2009 Oct;31(5):555-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Comparison of efficacy and adverse effects between arsenic trioxide and all-trans retinoic acid in patients with acute promyelocytic leukemia].
  • OBJECTIVE: To compare the efficacy and adverse effects between arsenic trioxide (ATO) and all-trans retinoic acid (ATRA) in patients with acute promyelocytic leukemia (APL).
  • METHODS: The clinical data of 71 patients with newly diagnosed APL were retrospectively analyzed.
  • Retinoic acid syndrome occurred in 52.9% of patients treated with ATRA, which affected the further use of ATRA.
  • CONCLUSIONS: Both ATO and ATRA have high response rates for newly diagnosed patients with APL.
  • Compared with ATRA, ATO induction therapy has shorter time to achieve CR and less adverse effects, and therefore may be the first-line therapy for APL.
  • [MeSH-major] Arsenicals / therapeutic use. Leukemia, Promyelocytic, Acute / drug therapy. Oxides / therapeutic use. Tretinoin / therapeutic use

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  • (PMID = 19968069.001).
  • [ISSN] 1000-503X
  • [Journal-full-title] Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
  • [ISO-abbreviation] Zhongguo Yi Xue Ke Xue Yuan Xue Bao
  • [Language] chi
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Arsenicals; 0 / Oxides; 5688UTC01R / Tretinoin; S7V92P67HO / arsenic trioxide
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85. Qin YG: [The main mechanism of the reinforcing-reducing method in Huangdi's Internal Classic is to promote qi with thought]. Zhongguo Zhen Jiu; 2007 Mar;27(3):217-21
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  • The method has a strong reinforcing-reducing function and do not need the needle feeling, and is directly related with doctor's idea.
  • It is emphasized specially that it can be carefully adopted only when full syndrome differentiation is made and strictly obey the contraindications in Huangdi's Internal Classic, otherwise it has very serious danger.

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  • (PMID = 17432652.001).
  • [ISSN] 0255-2930
  • [Journal-full-title] Zhongguo zhen jiu = Chinese acupuncture & moxibustion
  • [ISO-abbreviation] Zhongguo Zhen Jiu
  • [Language] chi
  • [Publication-type] English Abstract; Historical Article; Journal Article
  • [Publication-country] China
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86. Wu LZ, Wang Q: [Treatment of spasmodic torticollis by differentiation of symptoms and signs]. Zhongguo Zhen Jiu; 2008 Nov;28(11):823-5
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  • [Title] [Treatment of spasmodic torticollis by differentiation of symptoms and signs].
  • The authors apply flexibly the theory of treatment based on syndrome differentiation and fully exert the advantages of TCM to analyze the disease from pathogenic factor, disease and syndrome, pathogenesis and so on, and originally create acupuncture at "Wu Xin Xue" for treatment of this disease with Kaiqiao Shunjin method (resuscitation and regulating muscle) as main, clinically attaining satisfactory therapeutic effect.
  • [MeSH-major] Acupuncture Therapy. Medicine, Chinese Traditional. Torticollis / diagnosis. Torticollis / therapy
  • [MeSH-minor] Adolescent. Adult. Diagnosis, Differential. Humans. Male

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  • (PMID = 19055288.001).
  • [ISSN] 0255-2930
  • [Journal-full-title] Zhongguo zhen jiu = Chinese acupuncture & moxibustion
  • [ISO-abbreviation] Zhongguo Zhen Jiu
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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87. Wen CP, Xie ZJ, Song P: [Relationship between TCM syndrome type and expression of human leucocyte antigen DR gene in patients with systemic lupus erythematosus]. Zhongguo Zhong Xi Yi Jie He Za Zhi; 2008 Jun;28(6):499-501
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Relationship between TCM syndrome type and expression of human leucocyte antigen DR gene in patients with systemic lupus erythematosus].
  • OBJECTIVE: To explore the expression of human leucocyte antigen DR (HLA-DR) gene in peripheral blood mononuclear cells (PBMCs) of systemic lupus erythematosus (SLE) patients of various TCM syndrome types in order to seek an objective index for syndrome differentiation of SLE.
  • METHODS: SLE patients were sorted into various syndrome types by TCM syndrome differentiation, i. e.
  • RESULTS: Comparisons among patients of various syndrome type showed that the proportion of HLA-DR positive monocytes and lymphocytes in PBMC in patients of type A was the lowest (P < 0.01); proportion of HLA-DR positive lymphocytes in patients of type B was significantly higher than in those of type C and D (P < 0.01), and that in type D was higher than in type C (P < 0.05); total proportion of HLA-DR positive cells in patients of type A was the lowest, that in type B was higher than that in type C and D (P < 0.01, P < 0.05), while no significant difference was found between the latter two types (P > 0.05).
  • CONCLUSION: HLA-DR could be taken as an objective index for reference in syndrome differentiation of SLE.


88. Ding Y, Shi X, Guan L, Yang Z, Bai J, Zhang WP: [Study on relationship between the C-V curve of the source points of 12 channels and cold and heat syndromes of channels]. Zhongguo Zhen Jiu; 2007 Jan;27(1):31-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To observe the relationship between C-V curve of the source points of 12 channels and cold Eighty patients with cold or heat syndrome were examined with Cowital Human Meor heat syndrome.
  • CONCLUSION: The method can be used to set up and perfect the syndrome differentiation with cold-heat principle of meridian.

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  • (PMID = 17378200.001).
  • [ISSN] 0255-2930
  • [Journal-full-title] Zhongguo zhen jiu = Chinese acupuncture & moxibustion
  • [ISO-abbreviation] Zhongguo Zhen Jiu
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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89. Zhang H, Liu BY, Zhou XZ, Wang YH, Liu ZS: [Summary of professor Tian Cong-huo's commonly-used acupoint prescriptions]. Zhongguo Zhen Jiu; 2007 Sep;27(9):673-6
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  • Clinically, professor TIAN Cong-huo pays attention to treatment based on syndrome differentiation, with acupoint selection based on syndrome differentiation.
  • [MeSH-minor] Diagnosis, Differential. Humans

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  • (PMID = 17926621.001).
  • [ISSN] 0255-2930
  • [Journal-full-title] Zhongguo zhen jiu = Chinese acupuncture & moxibustion
  • [ISO-abbreviation] Zhongguo Zhen Jiu
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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90. Nie H, Wang Q, Li RH: [About the mutual compensation between advantages of Chinese and Western medical subjective indices for measurement and evaluation]. Zhongguo Zhong Xi Yi Jie He Za Zhi; 2010 Dec;30(12):1317-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • SIM/E has played important guideline roles in Chinese medicine (CM) clinical practice, and since it is characterized by holism and syndrome differentiation, it showed great advantage in comprehensive evaluation and result interpretation, though further standardization is yet required.
  • To analyze the related tools and scientific regulations of SIM/E in Western medicine, and establish the concept, domain and conceptual framework of a SIM/E system based on the CM syndrome theory should be feasible to realize the mutual compensation between advantages of the two medical sciences, and promote the progress of SIM/E.

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  • (PMID = 21302499.001).
  • [ISSN] 1003-5370
  • [Journal-full-title] Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine
  • [ISO-abbreviation] Zhongguo Zhong Xi Yi Jie He Za Zhi
  • [Language] CHI
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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91. Zhou EH, Deng BY, Su SY, Li YF: [Analysis on literature about syndrome differentiation and treatment of meridians in clinical acupuncture and moxibustion in recent 3 years]. Zhongguo Zhen Jiu; 2005 Jan;25(1):41-2
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  • [Title] [Analysis on literature about syndrome differentiation and treatment of meridians in clinical acupuncture and moxibustion in recent 3 years].
  • OBJECTIVE: To understand clinical application of syndrome differentiation and treatment of meridians in acupuncture and moxibustion.
  • METHODS: Collect and collate the literature about syndrome differentiation and treatment of meridians in Chinese Acupuncture & Moxibustion, Acupuncture Research, Shanghai Journal of Acupuncture & Moxibustion (Clinic edition B in 2003) and Clinical Journal of Acupuncture and Moxibustion from 2001 to 2003.
  • RESULTS: Less literature about syndrome differentiation and treatment of meridians are involved, only accounting for 5.69% (163/2 864); and the literature about both treatment based on meridians and treatment based on syndrome differentiation of meridians only accounted for 1.22% (35/2 864).
  • CONCLUSION: At present, clinically acupuncture and moxibustion do not play attention to treatment based on syndrome differentiation of meridians.

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  • (PMID = 16309155.001).
  • [ISSN] 0255-2930
  • [Journal-full-title] Zhongguo zhen jiu = Chinese acupuncture & moxibustion
  • [ISO-abbreviation] Zhongguo Zhen Jiu
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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92. Lian XF, Luo XD: [Effect of TCM treatment according to syndrome differentiation in enhancing curative effect and reducing side-effect of madopa]. Zhongguo Zhong Xi Yi Jie He Za Zhi; 2007 Sep;27(9):796-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Effect of TCM treatment according to syndrome differentiation in enhancing curative effect and reducing side-effect of madopa].
  • OBJECTIVE: To observe the effect of TCM treatment according to syndrome differentiation in en-hancing curative effect and reducing side-effect of madopa in patients with Parkinson' s disease (PD).
  • CONCLUSION: TCM treatment according to syndrome differentiation could improve the clinical symptoms and reduce complications in PD patients, which could enhance curative effect and reduce side-effect of madopa.

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  • (PMID = 17969890.001).
  • [ISSN] 1003-5370
  • [Journal-full-title] Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine
  • [ISO-abbreviation] Zhongguo Zhong Xi Yi Jie He Za Zhi
  • [Language] CHI
  • [Publication-type] English Abstract; Journal Article; Randomized Controlled Trial
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Dopamine Agents; 0 / Drug Combinations; 0 / Drugs, Chinese Herbal; 0 / benserazide, levodopa drug combination; 0 / pabing 1; 46627O600J / Levodopa; 762OS3ZEJU / Benserazide
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93. da Costa Moraes CA, Trompieri NM, Cavalcante Felix FH: Pediatric acute promyelocytic leukemia: all-transretinoic acid therapy in a Brazilian pediatric hospital. J Pediatr Hematol Oncol; 2008 May;30(5):387-90
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  • [Title] Pediatric acute promyelocytic leukemia: all-transretinoic acid therapy in a Brazilian pediatric hospital.
  • Acute promyelocytic leukemia (APL) is an uncommon form of pediatric acute nonlymphocytic leukemia.
  • It is characterized by clinical (refractory coagulopathy), morphologic (promyelocytic differentiation arrest), and cytogenetic t(15;17) hallmarks.
  • The introduction of all-transretinoic acid (ATRA) or tretinoin, a biologic response modifier, in its therapy was followed by dramatic improvement in its outcome.
  • To show the results of APL treatment in our hospital, we reviewed the information about 15 patients less than 18 years old, newly diagnosed with APL between November 2002 and November 2006.
  • The diagnosis was made upon examination of bone marrow aspirates.
  • The clinical charts were searched for data regarding clinical presentation, diagnosis, initial response with induction therapy, toxicity of ATRA, and antracyclic drug (daunorubicin).
  • Only 1 patient was diagnosed with ATRA syndrome.
  • Preliminary results are encouraging and confirm that ATRA is safe and efficacious as first choice therapy for APL.
  • [MeSH-major] Leukemia, Promyelocytic, Acute / drug therapy. Tretinoin / therapeutic use

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  • (PMID = 18458575.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 5688UTC01R / Tretinoin
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94. Yang XM, Wang GL, Li DX: [Studies on developmental features of theories of syndrome differentiation of zang-fu viscera in Qin and Han Dynasties]. Zhonghua Yi Shi Za Zhi; 2006 Jul;36(3):152-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Studies on developmental features of theories of syndrome differentiation of zang-fu viscera in Qin and Han Dynasties].
  • The formation of the theories of visceral manifestations as well as channels and collaterals in the books Huangdi Neijing (Inner Canon of Huangdi) and Nan Jing (Classic of Questioning) laid down the theoretical foundation for the theories of syndrome differentiation of zang--fu viscera.
  • From the early occurrence of syndrome classification to that of the disease manifestations of zang and fu viscera, the theories of syndrome differentiation of zang--fu viscera were basically not put into practice until Shanghan Zabing Lun (Treatise on Cold Pathogenic and Miscellaneous Diseases) appeared.
  • The theories of syndrome differentiation of zang--fu viscera in the Qin and Han Dynasties were not systematic and were scattered, indicating that it was a period of gestation for the theories.
  • [MeSH-minor] Books. History, Ancient. Humans. Syndrome

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  • (PMID = 17278438.001).
  • [ISSN] 0255-7053
  • [Journal-full-title] Zhonghua yi shi za zhi (Beijing, China : 1980)
  • [ISO-abbreviation] Zhonghua Yi Shi Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Historical Article; Journal Article
  • [Publication-country] China
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95. Xie P, Zhou XX, Zhang Q: [Pathogenesis and treatment of non-alcoholic fatty liver disease]. Zhong Xi Yi Jie He Xue Bao; 2010 Mar;8(3):201-9
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  • In the treatment of NAFLD, beside the conventionally used methods such as IR improvement, antioxidation and lipid metabolism improvement, other medicines such as nuclear metabolism ligands or activators, iron-chelating agents and syndrome differentiation treatment in traditional Chinese medicine also have good efficacy.

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  • (PMID = 20226139.001).
  • [ISSN] 1672-1977
  • [Journal-full-title] Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
  • [ISO-abbreviation] Zhong Xi Yi Jie He Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antioxidants; 0 / Leptin
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96. Leu L, Mohassel L: Arsenic trioxide as first-line treatment for acute promyelocytic leukemia. Am J Health Syst Pharm; 2009 Nov 1;66(21):1913-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Arsenic trioxide as first-line treatment for acute promyelocytic leukemia.
  • PURPOSE: The history, clinical pharmacology and toxicities, and role of arsenic trioxide as a first-line agent for treating acute promyelocytic leukemia (APL) are described.
  • SUMMARY: APL is most often characterized by the hallmark reciprocal translocation between chromosomes 15 and 17, leading to the fusion of the promyelocytic gene and retinoic acid receptor alpha.
  • Arsenic trioxide demonstrates a dual, dose-dependent mechanism of action and can induce both partial myeloid differentiation and apoptosis.
  • Toxicities associated with arsenic trioxide include leukocytosis, Q-T interval prolongation, APL differentiation syndrome, and hepatotoxicity.
  • Since 2000, arsenic trioxide has been used as the standard of care for relapsed APL, with remission rates greater than 80% as a single agent.
  • In an attempt to maximize disease-free survival and minimize relapse rates in patients with APL, arsenic trioxide is now being investigated as first-line therapy in the management of APL, with several studies showing promising outcomes.
  • CONCLUSION: Arsenic trioxide, alone or in combination with tretinoin, as first-line therapy in newly diagnosed APL has resulted in high rates of complete remission and molecular remission.
  • Arsenic trioxide combined with tretinoin has shortened the time to achieve complete remission and lengthened disease-free survival, findings that suggest the usefulness of the regimen as first-line treatment for APL.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Arsenicals / therapeutic use. Leukemia, Promyelocytic, Acute / drug therapy. Oxides / therapeutic use

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  • (PMID = 19850784.001).
  • [ISSN] 1535-2900
  • [Journal-full-title] American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
  • [ISO-abbreviation] Am J Health Syst Pharm
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Arsenicals; 0 / Oxides; 5688UTC01R / Tretinoin; S7V92P67HO / arsenic trioxide
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97. Hou FG, Cen Y, Guan J, Zhu LY, Yin XL: [Quantified diagnositic standard for large intestinal cancer of spleen qi deficiency syndrome.]. Zhong Xi Yi Jie He Xue Bao; 2009 Sep;7(9):814-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Quantified diagnositic standard for large intestinal cancer of spleen qi deficiency syndrome.].
  • OBJECTIVE: To set a quantified diagnostic standard for large intestinal cancer of spleen qi deficiency syndrome.
  • METHODS: The spleen qi deficiency syndrome was identified by experts on the basis of clinical epidemiological investigation of 311 patients suffering from large intestinal cancer.
  • Corresponding points were assigned to the correlative factors (traditional Chinese medicine symptoms) on the basis of symptom differences between spleen qi deficiency syndrome and non-spleen-qi-deficiency syndrome.
  • The best threshold was determined by receiver operating characteristic curve (ROC) according to syndrome differentiation from expert team, and the quantified diagnostic standard was established.
  • The syndrome identification from the expert team which was regarded as golden standard was tested retrospectively.
  • RESULTS: All the traditional Chinese medicine symptoms possibly related to spleen qi deficiency syndrome were analyzed based on the opinions of experts, and 28 symptoms were confirmed as candidate correlative factors.
  • The occurrence of 11 symptoms between spleen qi deficiency syndrome and non-spleen-qi-deficiency syndrome showed statistical differences by means of crosstabs analysis (P<0.05).
  • The diagnostic standard of spleen qi deficiency syndrome of large intestinal cancer was over 13 points.
  • CONCLUSION: The quantified diagnostic standard for spleen qi deficiency syndrome of large intestinal cancer is in accordance with clinical characteristics of large intestine cancer and the characteristics of TCM syndrome diagnosis.
  • [MeSH-major] Intestinal Neoplasms / diagnosis. Splenic Diseases / diagnosis
  • [MeSH-minor] Humans. Medicine, Chinese Traditional. Qi. Spleen. Syndrome

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  • (PMID = 19747434.001).
  • [ISSN] 1672-1977
  • [Journal-full-title] Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
  • [ISO-abbreviation] Zhong Xi Yi Jie He Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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98. Li CQ: [Application of "Bazhen prescription" in clinical acupuncture and moxibustion]. Zhongguo Zhen Jiu; 2007 Feb;27(2):147-9
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  • This is a proved recipe summarized by tens years' clinical practice of the author's grandfather and farther, and is a basic recipe for general treatment, treatment based on TCM differentiation and supplementing both qi and blood, with functions similar to Chinese medicine "Bazhen Decoction".
  • Practice proves that for all the diseases and syndromes of deficiency of qi and blood, if only differentiation of syndromes is correct, satisfactory results will be obtained.

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  • (PMID = 17370502.001).
  • [ISSN] 0255-2930
  • [Journal-full-title] Zhongguo zhen jiu = Chinese acupuncture & moxibustion
  • [ISO-abbreviation] Zhongguo Zhen Jiu
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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99. Di Simone N, Luigi MP, Marco D, Fiorella DN, Silvia D, Clara DM, Alessandro C: Pregnancies complicated with antiphospholipid syndrome: the pathogenic mechanism of antiphospholipid antibodies: a review of the literature. Ann N Y Acad Sci; 2007 Jun;1108:505-14
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pregnancies complicated with antiphospholipid syndrome: the pathogenic mechanism of antiphospholipid antibodies: a review of the literature.
  • There are several possible mechanisms by which antiphospholipid antibodies (aPL) may have adverse effects on placental functions.
  • Examination of placentas and first-trimester decidua from antiphospholipid syndrome-complicated pregnancies has found little evidence of specific thrombotic placental pathology.
  • It is now generally accepted that the clinically relevant aPL bind to proteins with affinity for phospholipids.
  • The most important epitope for antiphospholipid syndrome-related aPL resides on beta2-glycoprotein-I (beta2GPI).
  • aPL detected by anti-beta2GPI assays are associated with fetal loss.
  • During differentiation to syncytium, trophoblasts express cell membrane anionic phospholipids that can bind beta2GPI.
  • The improved outcome of pregnancies treated with heparin stimulated interest on the drug's mechanism of action.
  • It might reduce the binding of aPL, inflammation by inhibiting complement activation, and might facilitate implantation.
  • Further investigations are needed to better understand how aPL induce obstetric complications and to better clarify the functional role of heparin in the human placenta, leading to more successful therapeutic options.
  • [MeSH-major] Antibodies, Antiphospholipid / immunology. Antiphospholipid Syndrome / immunology. Pregnancy Complications / etiology. Trophoblasts / immunology

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  • (PMID = 17894016.001).
  • [ISSN] 0077-8923
  • [Journal-full-title] Annals of the New York Academy of Sciences
  • [ISO-abbreviation] Ann. N. Y. Acad. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Antiphospholipid; 0 / Autoantigens; 0 / beta 2-Glycoprotein I; 9005-49-6 / Heparin
  • [Number-of-references] 55
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100. Shen ZY: [An outstanding feature of traditional Chinese medicine: improving local pathology by regulating holistic function]. Zhongguo Zhong Xi Yi Jie He Za Zhi; 2006 Dec;26(12):1122-5
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  • Holistic conception reflects that "Syndrome" summarizes all aspects and conditions related to occurrence of disease referring to different constitutions.
  • "Treatment according to syndrome differentiation" improves local pathological changes through regulating holistic function, which is the practical application of holistic conception and an outstanding feature of TCM.
  • According to syndrome differentiation, treatment shows favorable effects on local pathological changes as restenosis after coronary artery intervention therapy, excessive inflammation, vascular endothelial injury in coronary artery disease and hypoadrenocortical function with drugs for promoting blood to remove blood stasis, clearing heat and detoxifying toxin, and warming Shen-yang, and aromatic drugs for warming meridian to dredge obstruction.

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  • (PMID = 17205828.001).
  • [ISSN] 1003-5370
  • [Journal-full-title] Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine
  • [ISO-abbreviation] Zhongguo Zhong Xi Yi Jie He Za Zhi
  • [Language] CHI
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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