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1. Nisar PJ, Scott HJ: Myocutaneous flap reconstruction of the pelvis after abdominoperineal excision. Colorectal Dis; 2009 Oct;11(8):806-16
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Anus Neoplasms / surgery. Perineum / surgery. Rectal Neoplasms / surgery. Surgical Flaps

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  • (PMID = 19055518.001).
  • [ISSN] 1463-1318
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 51
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2. O'Lorcain P, Deady S, Comber H: Mortality predictions for colon and anorectal cancer for Ireland, 2003-17. Colorectal Dis; 2006 Jun;8(5):393-401
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Log and log-linear Poisson regression modelling was fitted to colorectal cancer mortality data for each year between 1950 and 2002 to predict average European age standardized mortality rates (EASMRs) per 100,000 person years (100,000 PY(-1)) and average numbers of deaths.
  • [MeSH-major] Anus Neoplasms / mortality. Colonic Neoplasms / mortality. Mortality / trends. Rectal Neoplasms / mortality


3. Ben AJ, Bouasker I, Najah H, Zribi H, Bedoui R, Guesmi F, Hani MA, Nouira R, Zoghlami A, Najah N: Squamous cell carcinoma arising in Verneuil's disease. Tunis Med; 2008 Feb;86(2):169-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Squamous cell carcinoma arising in Verneuil's disease.
  • BACKGROUND: Verneuil's disease or hidradenitis suppurativa is a chronic suppurative, and cicatricial inflammatory disease, mainly affecting apocrine-bearing area of the skin.
  • AIM: To report a new case of squamous cell carcinoma arising in Verneuil's disease.
  • A wide surgical excision removing the tumour and leaving a large defect was performed.
  • [MeSH-major] Anus Neoplasms / complications. Carcinoma, Squamous Cell / complications. Hidradenitis Suppurativa / complications. Skin Neoplasms / complications


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4. Gaertner WB, Hagerman GF, Goldberg SM, Finne CO 3rd: Perianal Paget's disease treated with wide excision and gluteal skin flap reconstruction: report of a case and review of the literature. Dis Colon Rectum; 2008 Dec;51(12):1842-5
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  • [Title] Perianal Paget's disease treated with wide excision and gluteal skin flap reconstruction: report of a case and review of the literature.
  • BACKGROUND: Paget's disease of the anus is a rare perianal disorder.
  • Perianal Paget's disease was confirmed by histopathologic demonstration of Paget's cells from a biopsy.
  • No adjuvant therapy was necessary, and after one-year follow-up, the patient remains disease free.
  • CONCLUSION: Perianal Paget's disease continues to pose problems in diagnosis and treatment.
  • Our case report of perianal Paget's disease shows one method of management for advanced non invasive disease.
  • [MeSH-major] Anus Neoplasms / surgery. Paget Disease, Extramammary / surgery. Surgical Flaps

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  • (PMID = 18584248.001).
  • [ISSN] 1530-0358
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 34
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5. Oon SF, Winter DC: Perianal condylomas, anal squamous intraepithelial neoplasms and screening: a review of the literature. J Med Screen; 2010;17(1):44-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Perianal condylomas, anal squamous intraepithelial neoplasms and screening: a review of the literature.
  • Anal squamous intraepithelial lesions (ASILs) are the precursors to anal cancer.
  • Human papillomavirus infection has a direct link to ASIL formation and is responsible for up to 80% of anal cancers.
  • But while much importance has been focused on targeting cancer precursors in the cervix, relatively little concern has been afforded to the anal canal.
  • However, marked similarities in the biological and pathological profiles of cervical cancer and anal cancer mean that anal cancer should be preventable in the same way - by curbing the progression of ASIL to cancer.
  • This article explores the literature on ASILs and the growing problem of anal cancer in the community, along with the literature surrounding the current progress towards implementing a screening programme for ASIL in the future.
  • [MeSH-major] Anus Neoplasms / diagnosis. Carcinoma, Squamous Cell / diagnosis. Cervical Intraepithelial Neoplasia / diagnosis. Condylomata Acuminata / diagnosis. Papillomavirus Infections / complications. Uterine Cervical Neoplasms / diagnosis


6. Tider DS, Caprio GR, Gaisa M, Klein RS, Goldstone SE: Successful initiation of an anal cancer screening and treatment program at a New York City HIV clinic. AIDS; 2010 Apr 24;24(7):1085-6; author reply 1086-7
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  • [Title] Successful initiation of an anal cancer screening and treatment program at a New York City HIV clinic.
  • [MeSH-major] Anus Neoplasms / diagnosis. HIV Infections / complications


7. Capdevila J, Ramos FJ, Macarulla T, Elez E, Ruiz-Echarri M, Perez-Garcia J, Tabernero J: Development of new drug strategies in infrequent digestive tumors: esophageal, biliary tract, and anal cancers. Curr Opin Oncol; 2009 Jul;21(4):374-80
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  • [Title] Development of new drug strategies in infrequent digestive tumors: esophageal, biliary tract, and anal cancers.
  • PURPOSE OF REVIEW: In the last years, interesting advances have been reported in the treatment of infrequent digestive tumors.
  • The results of the biggest phase III trial in locally advanced anal carcinoma have been recently published.
  • Finally, the inhibition of epidermal growth factor receptor has also showed promising activity in anal carcinomas.
  • Although the major advances in targeted therapy have been introduced in the treatment of colorectal cancer, new interesting approaches have been reported in less frequent gastrointestinal tumors such as esophageal, biliary tract, and anal canal carcinoma opening a new hope in the treatment of these rare tumors in the molecular targeted therapy era.
  • [MeSH-major] Digestive System Neoplasms / drug therapy
  • [MeSH-minor] Angiogenesis Inhibitors / therapeutic use. Anus Neoplasms / blood supply. Anus Neoplasms / drug therapy. Anus Neoplasms / enzymology. Biliary Tract Neoplasms / blood supply. Biliary Tract Neoplasms / drug therapy. Biliary Tract Neoplasms / enzymology. Drug Delivery Systems. Esophageal Neoplasms / blood supply. Esophageal Neoplasms / drug therapy. Esophageal Neoplasms / enzymology. Humans. Neovascularization, Pathologic / drug therapy. Receptor, Epidermal Growth Factor / antagonists & inhibitors

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  • (PMID = 19412097.001).
  • [ISSN] 1531-703X
  • [Journal-full-title] Current opinion in oncology
  • [ISO-abbreviation] Curr Opin Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
  • [Number-of-references] 65
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8. Pedersen ME, Rahr HB, Fenger C, Qvist N: Adenocarcinoma arising from the rectal stump eleven years after excision of an ileal J-pouch in a patient with ulcerative colitis: report of a case. Dis Colon Rectum; 2008 Jul;51(7):1146-8
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  • We report a case of adenocarcinoma in the anal canal 11 years after removal of a failed ileal J-pouch.
  • The anus had been left in place at the pouch excision because of severe fibrosis in the pelvis.
  • [MeSH-major] Adenocarcinoma, Mucinous / etiology. Colitis, Ulcerative / surgery. Colonic Pouches / pathology. Rectal Neoplasms / etiology
  • [MeSH-minor] Anastomosis, Surgical. Biopsy. Diagnosis, Differential. Fatal Outcome. Follow-Up Studies. Humans. Ileostomy. Male. Middle Aged. Proctocolectomy, Restorative / methods. Time Factors. Tomography, X-Ray Computed

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  • (PMID = 18437493.001).
  • [ISSN] 1530-0358
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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9. Lim JF, Tjandra JJ, Hiscock R, Chao MW, Gibbs P: Preoperative chemoradiation for rectal cancer causes prolonged pudendal nerve terminal motor latency. Dis Colon Rectum; 2006 Jan;49(1):12-9
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  • Patients who had rectal cancer with a distal margin within 6 cm of the anal verge had the anus included in the field of radiotherapy (Group A, n = 26).
  • Patients who had rectal cancer with a distal margin 6 to 12 cm from the anal verge had shielding of the anus during radiotherapy (Group B, n = 40).
  • The maximum resting anal pressures were unchanged after chemoradiation.
  • The maximum squeeze anal pressures were reduced (mean = 166.5-157.5 mmHg) after chemoradiation.
  • These 18 patients similarly had a worsened median Wexner continence score (range, 0-3) and maximum squeeze anal pressures (mean = 165.5-144 mmHg).
  • The results obtained were independent of tumor response to chemoradiation.
  • [MeSH-major] Adenocarcinoma / therapy. Fluorouracil / therapeutic use. Leucovorin / therapeutic use. Motor Neurons. Peripheral Nervous System Diseases / etiology. Rectal Neoplasms / therapy. Rectum / innervation

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  • (PMID = 16292664.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 12001-76-2 / Vitamin B Complex; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil
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10. Saarilahti K, Arponen P, Vaalavirta L, Tenhunen M: The effect of intensity-modulated radiotherapy and high dose rate brachytherapy on acute and late radiotherapy-related adverse events following chemoradiotherapy of anal cancer. Radiother Oncol; 2008 Jun;87(3):383-90
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  • [Title] The effect of intensity-modulated radiotherapy and high dose rate brachytherapy on acute and late radiotherapy-related adverse events following chemoradiotherapy of anal cancer.
  • BACKGROUND AND PURPOSE: To investigate acute and late radiotherapy-related adverse events following intensity-modulated radiotherapy (IMRT) and high dose rate (HDR) brachytherapy of anal cancer.
  • MATERIALS AND METHODS: Fifty-nine consecutive patients treated by chemoradiotherapy for anal squamous cell cancer were evaluated for acute and late radiotherapy-related adverse events.
  • In 29 patients, the boost dose to the primary tumour was given by HDR brachytherapy: 30 patients were treated only by external radiotherapy.
  • A correlation between the equivalent dose in 2Gy fractions (EQD2) at the wall of anal canal opposite to the tumour and radiation proctitis was observed.
  • In patients that received the final boost dose to the primary tumour by HDR brachytherapy, a trend towards lower incidence of radiation proctitis was observed (P=0.065).
  • CONCLUSIONS: IMRT significantly reduces acute radiotherapy-associated adverse events in patients treated by chemoradiotherapy for anal cancer.
  • [MeSH-major] Anus Neoplasms / radiotherapy. Brachytherapy / adverse effects. Carcinoma, Squamous Cell / radiotherapy. Radiotherapy, Intensity-Modulated / adverse effects

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  • (PMID = 18501454.001).
  • [ISSN] 0167-8140
  • [Journal-full-title] Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
  • [ISO-abbreviation] Radiother Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
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11. Hoory T, Monie A, Gravitt P, Wu TC: Molecular epidemiology of human papillomavirus. J Formos Med Assoc; 2008 Mar;107(3):198-217
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  • These small, non-enveloped, double-stranded DNA viruses primarily infect the epithelium and induce benign as well as malignant lesions of the mucosa and skin.
  • Some HPVs are considered to be high-risk due to their strong implication in carcinogenesis, particularly the malignant progression of cervical tumors.
  • The recognition of papillomaviruses as a major etiologic agent for human cancers has increased their medical importance and stimulated research into developing strategies for the screening, diagnosis, prevention and treatment of HPV-associated diseases.

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  • (PMID = 18400605.001).
  • [ISSN] 0929-6646
  • [Journal-full-title] Journal of the Formosan Medical Association = Taiwan yi zhi
  • [ISO-abbreviation] J. Formos. Med. Assoc.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / 1R01 CA114425-01; United States / NCI NIH HHS / CA / 1R01 CA118790; United States / NCI NIH HHS / CA / P50 CA098252
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Review
  • [Publication-country] Singapore
  • [Number-of-references] 164
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12. Kim YA, Chung HC, Choi HJ, Rha SY, Seong JS, Jeung HC: Intermediate dose 5-fluorouracil-induced encephalopathy. Jpn J Clin Oncol; 2006 Jan;36(1):55-9
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  • Here, we report a case of a male with anal cancer who was treated with 5-FU 1000 mg/m(2), continuous infusion for 5 days q4 weeks.
  • In conclusion, we report that encephalopathy can develop even with the dose of 5-FU lower than ever reported, and it should be considered as a differential diagnosis for proper management.
  • [MeSH-minor] Aged. Antineoplastic Combined Chemotherapy Protocols / adverse effects. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Anus Neoplasms / drug therapy. Anus Neoplasms / pathology. Cisplatin / administration & dosage. Diagnosis, Differential. Dose-Response Relationship, Drug. Drug Administration Schedule. Humans. Hyperammonemia / complications. Infusions, Intravenous. Male. Neoplasm Invasiveness

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  • (PMID = 16436463.001).
  • [ISSN] 0368-2811
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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13. Venclauskas L, Saladzinskas Z, Tamelis A, Pranys D, Pavalkis D: Mucinous adenocarcinoma arising in an anorectal fistula. Medicina (Kaunas); 2009;45(4):286-90
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  • Mucinous adenocarcinoma in association with chronic anal fistula is a rare case in clinical practice.
  • The aim of this article was to report a rare case of anal gland mucinous adenocarcinoma in a patient who was treated in the Hospital of Kaunas University of Medicine.
  • Endoanal ultrasound findings showed soft tissue induration at the site of anorectal fistula, no tumor in the rectum wall.
  • Histological examination after abdominoperineal resection revealed anal duct mucinous adenocarcinoma pT2 N0 L0 V0 R0, G2.
  • [MeSH-major] Adenocarcinoma, Mucinous. Anus Neoplasms. Rectal Fistula / complications
  • [MeSH-minor] Abscess / complications. Aged. Anal Canal / pathology. Humans. Male. Neoplasm Staging. Perineum

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  • (PMID = 19423959.001).
  • [ISSN] 1648-9144
  • [Journal-full-title] Medicina (Kaunas, Lithuania)
  • [ISO-abbreviation] Medicina (Kaunas)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Lithuania
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14. Pereira AC, Lacerda HR, Barros RC: Diagnostic methods for prevention of anal cancer and characteristics of anal lesions caused by HPV in men with HIV/AIDS. Braz J Infect Dis; 2008 Aug;12(4):293-9
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  • [Title] Diagnostic methods for prevention of anal cancer and characteristics of anal lesions caused by HPV in men with HIV/AIDS.
  • Abnormalities found with anuscopy under colposcopic vision, anal cytology and anal biopsy were evaluated in 21 men with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) at the Federal University of Pernambuco Hospital in Brazil.
  • Reported sexual preference was 52.4% homosexuals, 28.6% bisexuals, and 19.0%heterosexuals; 81% reported having had receptive anal intercourse and 61.9% reported more than 10 sexual partners of the same sex.
  • Among the 21 anal cytology examinations, seven (33.3%) revealed low-grade squamous intraepithelial lesions (LSIL); three (14.3%) presented atypical squamous cells of undetermined significance (ASCUS) and 11 (52.4%) were normal.
  • Seventeen patients were submitted to anal biopsy with the following findings: three patients (17.6%) with normal epithelium, one (5.9%) with infection by HPV, three (17.6%) with condylomatas, two (11.8%) with AIN 1, four (23.6%) with AIN 2, three (17.6%) with AIN 3, and one (5.9%) with PAIN 2.
  • Anuscopy under colposcopic vision was found to be useful for detecting anal lesions and for guiding anal biopsies.
  • Anal cytology was less useful, as it underestimated the frequency of lesions.
  • [MeSH-major] Anus Diseases / diagnosis. Anus Neoplasms / prevention & control. HIV Infections / complications. Papillomavirus Infections / diagnosis


15. Branco BC, Sachar DB, Heimann T, Sarpel U, Harpaz N, Greenstein AJ: Adenocarcinoma complicating restorative proctocolectomy for ulcerative colitis with mucosectomy performed by Cavitron Ultrasonic Surgical Aspirator. Colorectal Dis; 2009 May;11(4):428-9
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  • The CUSA was introduced to simplify and optimize ileal pouch-anal anastomosis with mucosectomy and has been shown to shorten the operative time and reduce blood loss.
  • In the present case, even though preoperative colonoscopy had clearly shown dysplasia, the surgical pathology report could not detect any neoplasia in the specimen; hence, the patient was not surveyed for pouch cancer.
  • [MeSH-major] Adenocarcinoma / surgery. Anus Neoplasms / surgery. Colitis, Ulcerative / surgery. Neoplasm Recurrence, Local. Proctocolectomy, Restorative / methods. Vaginal Neoplasms / secondary


16. Piekarski JH, Jereczek-Fossa BA, Nejc D, Pluta P, Szymczak W, Sek P, Bilski A, Gottwald L, Jeziorski A: Does fecal diversion offer any chance for spontaneous closure of the radiation-induced rectovaginal fistula? Int J Gynecol Cancer; 2008 Jan-Feb;18(1):66-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Anus Diseases / surgery. Radiation Injuries / surgery. Rectovaginal Fistula / surgery. Uterine Cervical Neoplasms / radiotherapy
  • [MeSH-minor] Adult. Aged. Colostomy. Female. Follow-Up Studies. Humans. Middle Aged. Neoplasm Recurrence, Local / etiology. Retrospective Studies


17. Cotte E, Lifante JC, Cherki S, François Y, Vignal J, Peix JL, Glehen O: [Rectal amputation by pure perineal approach with laparoscopic colostomy: a palliative therapeutic option for low rectal or anal cancers for elderly patients with multiple comorbidities]. Ann Chir; 2006 Feb;131(2):100-3
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  • [Title] [Rectal amputation by pure perineal approach with laparoscopic colostomy: a palliative therapeutic option for low rectal or anal cancers for elderly patients with multiple comorbidities].
  • [Transliterated title] Amputation du rectum par voie périnéale pure avec colostomie coelio-assistée: une option thérapeutique palliative pour les cancers du bas rectum ou de l'anus chez le sujet âgé ou multitaré.
  • Rectal syndrome caused by locoregional evolution of low rectal cancers and anal cancers is prevented and treated by surgical resection.
  • The palliative treatment of low rectal cancers or anal cancers combining rectal amputation by pure perineal approach with laparoscopic colostomy may be an interesting therapeutic option for patients who cannot undergoing aggressive carcinologic surgical treatment.
  • [MeSH-major] Anus Neoplasms / surgery. Colostomy / methods. Laparoscopy. Palliative Care. Rectal Neoplasms / surgery. Rectum / surgery

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  • (PMID = 16430855.001).
  • [ISSN] 0003-3944
  • [Journal-full-title] Annales de chirurgie
  • [ISO-abbreviation] Ann Chir
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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18. Haddad F, Nadir S, Benkhaldoun L, Alaoui R, Cherkaoui A: [Primary anorectal melanoma]. Presse Med; 2005 Jan 29;34(2 Pt 1):85-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Nine cases of malignant anorectal melanoma were managed in the department of gastroenterology of the Ibn Rochd university hospital in Casablanca between 1984 and 2002.
  • The tumor was blackish in 4 cases.
  • One patient had undergone abdominoperineal resection, two transanal tumor resection, and in one patient radiotherapy was applied.
  • DISCUSSION: The prognosis of anorectal melanoma is frightening because of late diagnosis and high malignancy potential.
  • [MeSH-major] Anus Neoplasms / diagnosis. Anus Neoplasms / therapy. Melanoma / diagnosis. Melanoma / therapy. Rectal Neoplasms / diagnosis. Rectal Neoplasms / therapy
  • [MeSH-minor] Aged. Aged, 80 and over. Biopsy. Colonoscopy. Colostomy. Female. Follow-Up Studies. Hospitals, University. Humans. Immunohistochemistry. Lymphatic Metastasis. Male. Middle Aged. Morocco / epidemiology. Neoplasm Staging. Prognosis. Radiotherapy, Adjuvant. Rare Diseases. Remission Induction. Survival Rate. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 15687974.001).
  • [ISSN] 0755-4982
  • [Journal-full-title] Presse medicale (Paris, France : 1983)
  • [ISO-abbreviation] Presse Med
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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19. Haddock RL, Talon RJ, Whippy HJ: Ethnic disparities in cancer mortality among residents of Guam. Asian Pac J Cancer Prev; 2006 Jul-Sep;7(3):411-4
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  • ), colon-rectum-anus (28.6 vs. 19.7 U.S.
  • [MeSH-major] Ethnic Groups. Neoplasms / ethnology. Neoplasms / mortality

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  • [ErratumIn] Asian Pac J Cancer Prev. 2007 Jan-Mar;8(1):2
  • (PMID = 17059333.001).
  • [ISSN] 1513-7368
  • [Journal-full-title] Asian Pacific journal of cancer prevention : APJCP
  • [ISO-abbreviation] Asian Pac. J. Cancer Prev.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / 5 U56CA096278-02; United States / NCI NIH HHS / CA / RFA-CA-02-007
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Thailand
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20. Al-Daraji WI, Abdellaoui A, Salman WD: Osseous metaplasia in a tubular adenoma of the colon. J Clin Pathol; 2005 Feb;58(2):220-1
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  • Flexible sigmoidoscopy revealed a 1.5 cm polyp 30 cm from the anus.
  • [MeSH-major] Adenoma / pathology. Colonic Neoplasms / pathology. Ossification, Heterotopic / pathology

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  • (PMID = 15677548.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1770563
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21. Zhuang CP, Cai GY, Li TH, Wang YQ, Chen WR: [Efficacy evaluation of intersphincteric resection during anus-preserving operation for ultralow rectal carcinoma]. Zhonghua Wei Chang Wai Ke Za Zhi; 2009 Jul;12(4):364-7
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  • [Title] [Efficacy evaluation of intersphincteric resection during anus-preserving operation for ultralow rectal carcinoma].
  • METHODS: From January 2004 to August 2007, 30 patients with ultralow rectal carcinoma(2.5-4.0 cm distance from anal edge) underwent ISR.
  • The postoperative anal function was evaluated by Williams continence standard and the treatment outcome was followed up.
  • RESULTS: After ISR operation, anal resting pressure, maximum squeeze pressure and maximum tolerance volume of the rectum decreased significantly (all P<0.01) and restored gradually, but not to normal.
  • The rectal anal inhibitory reflex disappeared in 27 patients(90.0%) and was not improved.
  • According to Williams continence standard, 86.7%, 93.3% and 96.7% of patients obtained acceptable anal function in 3, 6, and 12 months after operation respectively.
  • Fecal eczema of anus occurred in 10 patients, colonic mucosa prolapse in 2 patients and stenosis of anal canal in one patient.
  • CONCLUSION: ISR for ultralow rectal carcinoma can not only attain radical treatment outcome, but also preserve anal sphincter.
  • [MeSH-major] Anal Canal / surgery. Anastomosis, Surgical / methods. Digestive System Surgical Procedures. Rectal Neoplasms / surgery

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  • (PMID = 19598020.001).
  • [ISSN] 1671-0274
  • [Journal-full-title] Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
  • [ISO-abbreviation] Zhonghua Wei Chang Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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22. Kazakov DV, Spagnolo DV, Stewart CJ, Thompson J, Agaimy A, Magro G, Bisceglia M, Vazmitel M, Kacerovska D, Kutzner H, Mukensnabl P, Michal M: Fibroadenoma and phyllodes tumors of anogenital mammary-like glands: a series of 13 neoplasms in 12 cases, including mammary-type juvenile fibroadenoma, fibroadenoma with lactation changes, and neurofibromatosis-associated pseudoangiomatous stromal hyperplasia with multinucleated giant cells. Am J Surg Pathol; 2010 Jan;34(1):95-103
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  • [Title] Fibroadenoma and phyllodes tumors of anogenital mammary-like glands: a series of 13 neoplasms in 12 cases, including mammary-type juvenile fibroadenoma, fibroadenoma with lactation changes, and neurofibromatosis-associated pseudoangiomatous stromal hyperplasia with multinucleated giant cells.
  • The authors present a series of 13 fibroepithelial neoplasms involving anogenital mammary-like glands, all occurring in 12 female patients, whose age at diagnosis ranged from 30 to 51 years (mean, 38 y; median, 42 y).
  • All women presented with a solitary asymptomatic nodule in the vulva (n=8), perineum (n=2), or near the anus (n=2) ranging in size from 1.5 to 4.5 cm.
  • Microscopically, 8 lesions were classified as fibroadenoma, and 5, including 1 recurrent tumor, as phyllodes tumor, of which 1 was benign and 4 low-grade malignant.
  • In addition to conventional findings, we describe several hitherto unreported features including juvenile fibroadenoma-like proliferation, fibroadenoma with lactation change, and pseudoangiomatous stromal hyperplasia with multinucleated stromal giant cells in a patient with neurofibromatosis, type 1 all constituting potential diagnostic pitfalls, which are best averted by using the same approach to diagnosis as for their analogous mammary counterparts.
  • [MeSH-major] Anus Neoplasms / pathology. Fibroadenoma / pathology. Genital Neoplasms, Female / pathology. Mammary Glands, Human / pathology. Phyllodes Tumor / pathology


23. Kawahara H, Watanabe K, Ushigome T, Noaki R, Kobayashi S, Yanaga K: Retrograde single stapling technique for laparoscopic ultralow anterior resection. Dig Surg; 2010;27(4):261-4
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  • After the anal side of the tumor has been closed transanally, the distal line in the right lateral wall of the rectum is partially transected with laparoscopic coagulation shears (LCS).
  • After an anvil is placed in the proximal end of the colon over a purse-string suture, it is introduced to the anal canal transabdominally.
  • For the prevention of anastomotic leakage, a 24-french balloon catheter which decompresses the anastomosis is inserted through the anus.
  • [MeSH-major] Laparoscopy / methods. Rectal Neoplasms / pathology. Rectal Neoplasms / surgery. Surgical Stapling / methods
  • [MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / surgery. Adult. Aged. Anal Canal / surgery. Anastomosis, Surgical / methods. Anastomotic Leak. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Proctoscopy / methods. Risk Assessment. Sampling Studies. Treatment Outcome

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  • [Copyright] Copyright 2010 S. Karger AG, Basel.
  • (PMID = 20668381.001).
  • [ISSN] 1421-9883
  • [Journal-full-title] Digestive surgery
  • [ISO-abbreviation] Dig Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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24. Grabenbauer GG, Lahmer G, Distel L, Niedobitek G: Tumor-infiltrating cytotoxic T cells but not regulatory T cells predict outcome in anal squamous cell carcinoma. Clin Cancer Res; 2006 Jun 1;12(11 Pt 1):3355-60
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  • [Title] Tumor-infiltrating cytotoxic T cells but not regulatory T cells predict outcome in anal squamous cell carcinoma.
  • PURPOSE: Tumor-infiltrating lymphocytes (TIL) are a possible prognostic factor in solid tumors.
  • We have evaluated the effect of T-cell subsets on survival in patients with anal squamous cell carcinoma following radiochemotherapy.
  • METHODS: Biopsy specimens from 38 patients with anal carcinomas were evaluated using tissue microarrays and immunohistochemistry for the presence of tumor-infiltrating immune cells using CD3, CD4, CD8, and CD68 antibodies.
  • Prognostic effect of TIL subsets was evaluated by the log-rank test comparing no evidence of disease survival for groups with high and low numbers using median values as cutoff.
  • RESULTS: CD3+ and CD4+ TILs influenced no evidence of disease survival: 3-year rates for patients with low numbers were 89% and 95%, respectively, and 54% (P = 0.02) and 48%, (P = 0.01), respectively, in cases with high numbers.
  • Large numbers of tumor-infiltrating granzyme B+ cytotoxic cells had a significant negative prognostic effect (P = 0.008), whereas no effect was observed for Treg.
  • CONCLUSIONS: TILs were identified as negative prognostic indicators in anal squamous cell carcinomas with granzyme B+ cytotoxic cells showing highest effect on outcome.
  • This is possibly explained by the selection of therapy-resistant tumor cell clones.
  • [MeSH-major] Anus Neoplasms / diagnosis. Carcinoma, Squamous Cell / diagnosis. Lymphocytes, Tumor-Infiltrating / immunology. T-Lymphocytes, Cytotoxic / immunology. T-Lymphocytes, Regulatory / immunology

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  • (PMID = 16740757.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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25. Nilsson PJ, Rubio C, Lenander C, Auer G, Glimelius B: Tumour budding detected by laminin-5 {gamma}2-chain immunohistochemistry is of prognostic value in epidermoid anal cancer. Ann Oncol; 2005 Jun;16(6):893-8
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  • [Title] Tumour budding detected by laminin-5 {gamma}2-chain immunohistochemistry is of prognostic value in epidermoid anal cancer.
  • BACKGROUND: Markers for guidance with regard to individual prognosis and treatment planning are sought in epidermoid anal cancer.
  • This study assessed the prognostic and predictive value of tumour budding.
  • Immunohistochemistry with a monoclonal antibody for the gamma2 chain of laminin-5 was used to detect tumour budding (defined as dissociated single cancer cells or clusters of up to five cells).
  • RESULTS: Tumour budding was detected in 104 (50%) of the 209 samples.
  • No significant correlation was found between tumour budding and clinicopathological characteristics.
  • Patients with tumour budding had a statistically significantly better 5-year overall survival rate compared with patients lacking tumour budding (74% versus 64%, P <0.05).
  • Albeit not statistically significant, other outcome variables such as tumour-specific survival, recurrence after initial complete response and rate of distant metastases, were all in favour of patients with tumour budding.
  • Multivariate analysis reveals tumour budding as an independent positive prognostic factor.
  • CONCLUSIONS: Tumour budding detected by laminin-5 immunohistochemistry may be of prognostic value in the treatment of epidermoid anal cancer.

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  • (PMID = 15821121.001).
  • [ISSN] 0923-7534
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / LAMC2 protein, human; 0 / Laminin
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26. Irabor DO, Dongo AE: Anal carcinoma in a tropical low socio-economic population in the new millennium: What has changed? Trop Doct; 2009 Jan;39(1):7-9
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  • [Title] Anal carcinoma in a tropical low socio-economic population in the new millennium: What has changed?
  • The paper is a retrospective look at the clinicopathological presentation of carcinoma of the anal canal in a tertiary health institution in Nigeria.
  • Sixty-five patients were diagnosed with anal carcinoma over a five-year period (2002-2006) from a total of 394 patients who had malignancies of the colon, rectum and anus.
  • The male: female ratio was 1.2: 1 showing a slight male predominance; the average age was 48 years; tenesmus, bleeding per rectum and anal pain were the most common presenting features.
  • [MeSH-major] Adenocarcinoma. Anus Neoplasms. Carcinoma
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Anal Canal / pathology. Anal Canal / surgery. Female. Humans. Male. Middle Aged. Nigeria / epidemiology. Socioeconomic Factors. Tropical Climate. Young Adult

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  • (PMID = 19211411.001).
  • [ISSN] 0049-4755
  • [Journal-full-title] Tropical doctor
  • [ISO-abbreviation] Trop Doct
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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27. Michalek-Sauberer A, Kozek-Langenecker SA, Heinzl H, Deusch E, Chiari A: Median effective local anesthetic doses of plain bupivacaine and ropivacaine for spinal anesthesia administered via a spinal catheter for brachytherapy of the lower abdomen. Reg Anesth Pain Med; 2008 Jan-Feb;33(1):4-9
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  • METHODS: Forty patients were randomly allocated to receive either intrathecal bupivacaine 5 mg per mL or ropivacaine 10 mg per mL via a 24-gauge spinal catheter at the L3-4 interspace.
  • [MeSH-minor] Abdomen. Adult. Aged. Aged, 80 and over. Anus Neoplasms / radiotherapy. Dose-Response Relationship, Drug. Female. Humans. Male. Middle Aged. Urogenital Neoplasms / radiotherapy

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  • [CommentIn] Reg Anesth Pain Med. 2009 Jan-Feb;34(1):73-4; author reply 734-5 [19258992.001]
  • [CommentIn] Reg Anesth Pain Med. 2008 Jan-Feb;33(1):1-3 [18155049.001]
  • (PMID = 18155050.001).
  • [ISSN] 1098-7339
  • [Journal-full-title] Regional anesthesia and pain medicine
  • [ISO-abbreviation] Reg Anesth Pain Med
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Amides; 0 / Anesthetics, Local; 7IO5LYA57N / ropivacaine; Y8335394RO / Bupivacaine
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28. de Góis NM, Costa RR, Kesselring F, de Freitas VG, Ribalta JC, Kobata MP, Taha NS: Grade 3 vulvar and anal intraepithelial neoplasia in a HIV seropositive child--therapeutic result: case report. Clin Exp Obstet Gynecol; 2005;32(2):138-40
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  • [Title] Grade 3 vulvar and anal intraepithelial neoplasia in a HIV seropositive child--therapeutic result: case report.
  • A case report of a HIV seropositive 8-year-old child with vulvar and anal border neoplasia, both grade 3, and the adopted therapeutic management are presented.
  • On physical examination a pigmented and elevated lesion was observed in the whole vulvar region extending to the anal region and intergluteal sulcus.
  • [MeSH-major] Anus Neoplasms / therapy. Carcinoma / therapy. HIV Infections / diagnosis. HIV Infections / drug therapy. Vulvar Neoplasms / therapy


29. Mosthaf FA, Hanhoff NJ, Goetzenich A, Wolf E, Knechten H: [High incidence of non-AIDS-defined cancers among HIV-infected patients in Germany. A 3-year nationwide review]. Dtsch Med Wochenschr; 2006 Aug 25;131(34-35):1849-52
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  • Additionally it sought to gain an impression of the realities of treatment of patients with HIV-associated malignant tumors in Germany.
  • PATIENTS AND METHODS: Over a period of 3 years (from the beginning of 2000 to the end of 2002) data were retrospectively collected on the incidence of malignant tumors in HIV-positive patients.
  • The data were collected on all AIDS- and not-AIDS-defined haematological malignancies and all AIDS- and not-AIDS-defined solid malignant tumors in HIV-positive patients, as well as on time of diagnosis of the malignancy, tumor stage, tumor treatment and response to treatment.
  • RESULTS: 380 data sets on 376 patients of 50 practices/clinics were included in the analysis (four patients had two malignant tumors).
  • 180 malignant neoplasms (47%) were AIDS-defined: 89 Kaposi's sarcomas, 82 aggressive B-cell lymphomas and 9 invasive cervical carcinomas.
  • The aggressive B-cell lymphomas consisted of 19 cases of Burkitt's lymphoma, 8 of Castleman's disease and 12 of primary cerebral malignant lymphoma.
  • Of the 200 (52.6%) not-AIDS-defined malignant tumors 133 were 133 solid tumors, 40 of them anal carcinoma (20% of all not-AIDS-defined malignancies) and 67 haematological malignancies, 22 of these Hodgkin's lymphoma (11.0% of all not-AIDS-defined malignancies).
  • The incidence of anal carcinoma is estimated to be 34 (95% CI 24-470) per 100 000 patient-years, that of Hodgkin's lymphoma 19 (95% CI 12-28) per 100 000 patient-years.
  • Of special note is the high incidence of anal carcinoma and Hodgkin's lymphoma, compared with their incidence among the entire German population.
  • [MeSH-major] Anus Neoplasms / epidemiology. HIV Infections / complications. Hodgkin Disease / epidemiology. Neoplasms / epidemiology. Neoplasms / virology


30. Katz MH, Katz KA, Bernestein KT, Klausner JD: We need data on anal screening effectiveness before focusing on increasing it. Am J Public Health; 2010 Nov;100(11):2016; author reply 2017
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  • [Title] We need data on anal screening effectiveness before focusing on increasing it.
  • [MeSH-major] Anus Neoplasms / prevention & control. Mass Screening. Papanicolaou Test

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31. Yoshinaga K, Obata H, Jurukovski V, Mazzieri R, Chen Y, Zilberberg L, Huso D, Melamed J, Prijatelj P, Todorovic V, Dabovic B, Rifkin DB: Perturbation of transforming growth factor (TGF)-beta1 association with latent TGF-beta binding protein yields inflammation and tumors. Proc Natl Acad Sci U S A; 2008 Dec 2;105(48):18758-63
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  • [Title] Perturbation of transforming growth factor (TGF)-beta1 association with latent TGF-beta binding protein yields inflammation and tumors.
  • Tgfb1(C33S/C33S) mice exhibited decreased levels of active TGF-beta1, decreased TGF-beta signaling, and tumors of the stomach, rectum, and anus.

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  • (PMID = 19022904.001).
  • [ISSN] 1091-6490
  • [Journal-full-title] Proceedings of the National Academy of Sciences of the United States of America
  • [ISO-abbreviation] Proc. Natl. Acad. Sci. U.S.A.
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / F32 HL067542; United States / NHLBI NIH HHS / HL / F32HL67542-01; United States / NCI NIH HHS / CA / T32 CA009161; United States / NCI NIH HHS / CA / R01 CA034282; United States / NCI NIH HHS / CA / T32 CA09161; United States / NIAMS NIH HHS / AR / P01 AR049698; United States / NCI NIH HHS / CA / CA034282; United States / NIAMS NIH HHS / AR / AR 049698
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Latent TGF-beta Binding Proteins; 0 / Protein Precursors; 0 / Transforming Growth Factor beta1
  • [Other-IDs] NLM/ PMC2596235
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32. Bertani E, Chiappa A, Mazzarol G, Contino G, Lazzari R, Zampino MG, Viale G, Andreoni B: Aggressive treatment approach for cloacogenic carcinoma of the anorectum: report from a single cancer center. Dig Surg; 2010;27(4):297-301
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  • BACKGROUND/AIMS: The prognosis of cloacogenic carcinoma of the anorectum has rarely been investigated, and its clinical behavior is supposed to be similar to common squamous anal cancers.
  • During the last 10 years, chemoradiation treatment (CRT) has been considered the standard of care for anal cancer.
  • Three patients presented distant metastases at the time of diagnosis.
  • RESULTS: After a mean follow-up time of 33 months (range 9-100), disease recurrence or progression was observed in 6 patients, which caused death in 3 of them.
  • CONCLUSIONS: Our data seem to suggest that the cloacogenic origin could present prognostic relevance within the wide spectrum of anal cancers.
  • However, this hypothesis needs to be confirmed by larger series of this disease.
  • [MeSH-major] Anus Neoplasms / pathology. Anus Neoplasms / therapy. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / therapy. Neoplasm Recurrence, Local / pathology
  • [MeSH-minor] Adult. Anal Canal / surgery. Biopsy, Needle. Cancer Care Facilities. Chemotherapy, Adjuvant. Cohort Studies. Combined Modality Therapy. Disease-Free Survival. Female. Follow-Up Studies. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Staging. Radiotherapy, Adjuvant. Retrospective Studies. Risk Assessment. Survival Analysis. Treatment Outcome

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  • [Copyright] Copyright 2010 S. Karger AG, Basel.
  • (PMID = 20689291.001).
  • [ISSN] 1421-9883
  • [Journal-full-title] Digestive surgery
  • [ISO-abbreviation] Dig Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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33. Lee PK, Wilkins KB: Condyloma and other infections including human immunodeficiency virus. Surg Clin North Am; 2010 Feb;90(1):99-112, Table of Contents
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  • This article reviews the presentation and management of the more common perianal STDs including human immunodeficiency virus, as well as the pathogenesis and management of anal intraepithelial neoplasia.
  • [MeSH-minor] Aminoquinolines / administration & dosage. Anti-Bacterial Agents / administration & dosage. Antineoplastic Agents / administration & dosage. Anus Neoplasms / virology. Chancroid. Female. HIV Infections. Herpes Genitalis / diagnosis. Herpesvirus 1, Human. Herpesvirus 2, Human. Humans. Male. Penicillin G / administration & dosage. Proctitis / virology. Rectal Diseases / virology. Sexually Transmitted Diseases / virology. Syphilis / drug therapy. Ulcer

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20109635.001).
  • [ISSN] 1558-3171
  • [Journal-full-title] The Surgical clinics of North America
  • [ISO-abbreviation] Surg. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Aminoquinolines; 0 / Anti-Bacterial Agents; 0 / Antineoplastic Agents; 99011-02-6 / imiquimod; Q42T66VG0C / Penicillin G
  • [Number-of-references] 42
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34. Pelle MT, Parc Y, Mourra N: c-Kit expression in spindle cell melanoma--a diagnostic pitfall in anorectal biopsy. Arch Pathol Lab Med; 2009 Aug;133(8):1189-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Anus Neoplasms / metabolism. Diagnostic Errors / prevention & control. Melanoma / metabolism. Proto-Oncogene Proteins c-kit / metabolism
  • [MeSH-minor] Aged. Biomarkers, Tumor / metabolism. Biopsy. Cytoplasm / metabolism. Cytoplasm / pathology. Female. Humans

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  • (PMID = 19653705.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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35. Carpenter JB, Rennels MA: Immunophenotypic characteristics of anal gland carcinoma. Arch Pathol Lab Med; 2008 Oct;132(10):1547-8
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  • [Title] Immunophenotypic characteristics of anal gland carcinoma.
  • [MeSH-major] Adenocarcinoma / metabolism. Anus Neoplasms / metabolism. Keratin-5 / metabolism. Keratin-6 / metabolism. Membrane Proteins / metabolism

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  • [CommentOn] Arch Pathol Lab Med. 2007 Aug;131(8):1304-11 [17683193.001]
  • (PMID = 18834205.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Comment; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CKAP4 protein, human; 0 / Keratin-5; 0 / Keratin-6; 0 / Keratin-7; 0 / Membrane Proteins
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36. Durães Lde C, Sousa JB: [Anal cancer and sexually transmitted diseases: what is the correlation?]. Rev Col Bras Cir; 2010 Aug;37(4):265-8
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  • [Title] [Anal cancer and sexually transmitted diseases: what is the correlation?].
  • [Transliterated title] Câncer anal e doenças sexualmente transmissíveis: qual a correlação?
  • OBJECTIVE: Anal cancer is a rare tumor, which incidence is influenced by sexual behavior.
  • The purpose of this paper is to verify the correlation between anal cancer and sexually transmitted diseases, such as HPV, HIV, Gonococci infection, Chlamydia infection, syphilis and others.
  • METHODS: All the internments due to anal cancer, HIV, HPV, syphilis, Gonococci infection, Chlamydia infection and other sexually transmitted diseases in public healthy in Brazil were collected at Datasus site between 1998 and 2007.
  • RESULTS: There was a high correlation between anal cancer and HPV admissions (r=0.98, p<0.001).
  • There was negative correlation between anal cancer and Gonococci infection admissions (r=-0.81, p=0.005) and anal cancer and Chlamydia infection (r=-0.74, p=0.014).
  • There was not statistic significant correlation between anal cancer and HIV admissions (r=0.40, p=0.245), between anal cancer and other sexually transmitted diseases (r=0.55, p=0.1), and between anal cancer and syphilis (r=-0.61, p=0.059).
  • CONCLUSION: There was a high positive correlation between anal cancer and HPV admissions in Brazil.
  • There were negative correlations between anal cancer and Gonococci infection and between anal cancer and Chlamydia infection admissions.
  • [MeSH-major] Anus Neoplasms / complications. Anus Neoplasms / epidemiology. Sexually Transmitted Diseases / complications. Sexually Transmitted Diseases / epidemiology

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  • (PMID = 21085842.001).
  • [ISSN] 1809-4546
  • [Journal-full-title] Revista do Colégio Brasileiro de Cirurgiões
  • [ISO-abbreviation] Rev Col Bras Cir
  • [Language] por
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Brazil
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37. Muñoz N, Castellsagué X, de González AB, Gissmann L: Chapter 1: HPV in the etiology of human cancer. Vaccine; 2006 Aug 31;24 Suppl 3:S3/1-10
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  • Most cancers of the vagina and anus are likewise caused by HPV, as are a fraction of cancers of the vulva, penis, and oropharynx.
  • HPV-16 and -18 account for about 70% of cancers of the cervix, vagina, and anus and for about 30-40% of cancers of the vulva, penis, and oropharynx.
  • [MeSH-major] Neoplasms / virology. Papillomaviridae / isolation & purification. Papillomavirus Infections / complications. Papillomavirus Infections / virology
  • [MeSH-minor] Conjunctival Neoplasms / virology. Female. Genital Neoplasms, Female / virology. Genital Neoplasms, Male / virology. Humans. Male. Oropharyngeal Neoplasms / virology. Skin Neoplasms / virology

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  • (PMID = 16949995.001).
  • [ISSN] 0264-410X
  • [Journal-full-title] Vaccine
  • [ISO-abbreviation] Vaccine
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 35
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38. Kfoury T, Staiti G, Baujard C, Benhamou D: Pudendal nerve block by nerve stimulation in a child with Waardenburg disease. Paediatr Anaesth; 2008 Dec;18(12):1267-8
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  • [Title] Pudendal nerve block by nerve stimulation in a child with Waardenburg disease.
  • [MeSH-minor] Anesthesia, Conduction. Anus Neoplasms / surgery. Child, Preschool. Electric Stimulation. Humans. Male. Rhabdomyosarcoma / surgery

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  • (PMID = 19076601.001).
  • [ISSN] 1460-9592
  • [Journal-full-title] Paediatric anaesthesia
  • [ISO-abbreviation] Paediatr Anaesth
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] France
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39. Saiprasad BR, Prasad MS, Ravishankar TH, Mathur K: Rectal polyp: can it be a malignant melanoma? Surgery; 2006 Sep;140(3):474-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Rectal polyp: can it be a malignant melanoma?
  • [MeSH-major] Anus Neoplasms / diagnosis. Colonic Polyps / diagnosis. Melanoma / diagnosis. Rectal Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Hemorrhoids / diagnosis. Hemorrhoids / pathology. Humans. Male. Prognosis

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  • (PMID = 16934613.001).
  • [ISSN] 0039-6060
  • [Journal-full-title] Surgery
  • [ISO-abbreviation] Surgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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40. Stojanović S, Radosević-Jelić I, Dabić-Stanković K, Popov I, Josifovski J: External beam radiotherapy plus brachytherapy boost in treatment of anal canal carcinoma. Acta Chir Iugosl; 2007;54(3):33-8
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  • [Title] External beam radiotherapy plus brachytherapy boost in treatment of anal canal carcinoma.
  • PURPOSE: Radiotherapy has been the standard treatment of anal canal carcinoma for the last three decades.
  • MATERIAL AND METHODS: At the Institute for Oncology and Radiology of Serbia, between March 1997 and May 2004, patients with anal canal carcinoma were treated with combined external beam radiotherapy and brachytherapy boost as primary treatment modality.
  • Total tumor dose in combined radiotherapy treatment ranged from 55-70 Gy.
  • In the median follow up time of 42 months, five-year overall survival was 71% and disease free survival was 61%.
  • [MeSH-major] Anus Neoplasms / radiotherapy. Brachytherapy

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  • (PMID = 17988027.001).
  • [ISSN] 0354-950X
  • [Journal-full-title] Acta chirurgica Iugoslavica
  • [ISO-abbreviation] Acta Chir Iugosl
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Serbia and Montenegro
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41. Helmke BM, Zahel T, Breinig M, Schirmacher P, Aulmann S, Kern MA: Her2 overexpression is a rare event in anorectal melanoma. Melanoma Res; 2010 Oct;20(5):431-4
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  • Anorectal melanomas (AMs) are very rare and highly malignant tumors that are often diagnosed in advanced stages.
  • After the differentiation between cutaneous melanoma (CM) and AM on the molecular level based on the presence of BRAF mutations, further modes of differentiation opened up, such as the recently discovered immunohistologically relevant protein deleted in malignant brain tumors 1 (DMBT1).
  • [MeSH-major] Anus Neoplasms / metabolism. Melanoma / metabolism. Receptor, ErbB-2 / metabolism. Rectal Neoplasms / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Gene Expression Regulation, Neoplastic. Humans. Incidence. Male. Middle Aged. Molecular Diagnostic Techniques. Skin Neoplasms / diagnosis. Skin Neoplasms / epidemiology. Skin Neoplasms / metabolism. Up-Regulation


42. Hoots BE, Palefsky JM, Pimenta JM, Smith JS: Human papillomavirus type distribution in anal cancer and anal intraepithelial lesions. Int J Cancer; 2009 May 15;124(10):2375-83
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  • [Title] Human papillomavirus type distribution in anal cancer and anal intraepithelial lesions.
  • A systematic review was conducted of HPV type distribution in anal cancer and anal high-grade and low-grade squamous intraepithelial lesions (HSIL and LSIL).
  • A total of 1,824 cases were included: 992 invasive anal cancers, 472 HSIL cases and 360 LSIL cases.
  • Crude HPV prevalence in anal cancer, HSIL, and LSIL was 71, 91 and 88%, respectively.
  • HPV16/18 prevalence was 72% in invasive anal cancer, 69% in HSIL and 27% in LSIL.
  • The HPV 16 and/or 18 prevalence in invasive anal cancer cases was similar to that reported in invasive cervical cancer.
  • If ongoing clinical trials show efficacy in preventing anal HPV infection and associated anal lesions, prophylactic HPV vaccines may play an important role for the primary prevention of these cancers in both genders.
  • [MeSH-major] Anus Neoplasms / virology. Carcinoma in Situ / virology. Papillomaviridae / isolation & purification
  • [MeSH-minor] DNA, Viral / genetics. Female. Humans. Male. Neoplasm Invasiveness. Species Specificity

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 19189402.001).
  • [ISSN] 1097-0215
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Viral
  • [Number-of-references] 26
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43. Papaconstantinou HT, Lee AJ, Simmang CL, Ashfaq R, Gokaslan ST, Sokol S, Huber PJ Jr, Gregorcyk SG: Screening methods for high-grade dysplasia in patients with anal condyloma. J Surg Res; 2005 Jul 1;127(1):8-13
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  • [Title] Screening methods for high-grade dysplasia in patients with anal condyloma.
  • HPV infection can cause anal condylomas and is a risk factor for dysplasia.
  • The purpose of this study is to determine whether anal cytology, morphological characteristics, and/or the presence of high-risk oncogenic HPV-types are effective noninvasive methods to detect high-risk anal condylomas.
  • PATIENTS AND METHODS: From November 2003 to June 2004, all patients with anal condyloma were prospectively evaluated for anal cytology, high-risk oncogenic HPV-types, and tissue biopsies.
  • Histology results served as true disease for all comparisons.
  • RESULTS: Forty-seven patients with anal condyloma were studied; 43 (91.5%) were men, and the mean age was 39 +/- 11 years.
  • CONCLUSION: Anal cytology alone is not accurate for detecting HRL in patients with anal condylomas.
  • Combining oncogenic HPV-testing with cytology is more sensitive in detecting HRL in patients with anal condyloma, and therefore, a more effective screening tool.
  • [MeSH-major] Anal Canal / pathology. Anus Diseases / pathology. Anus Neoplasms / pathology. Condylomata Acuminata / pathology. Papillomaviridae. Papillomavirus Infections / pathology. Tumor Virus Infections / pathology

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  • (PMID = 15964301.001).
  • [ISSN] 0022-4804
  • [Journal-full-title] The Journal of surgical research
  • [ISO-abbreviation] J. Surg. Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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44. El-Gazzaz G, Kiran RP, Lavery I: Wound complications in rectal cancer patients undergoing primary closure of the perineal wound after abdominoperineal resection. Dis Colon Rectum; 2009 Dec;52(12):1962-6
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  • PURPOSE: Perineal wound complications have a significant impact on postoperative morbidity after excision of the rectum and anus.
  • Data pertaining to demographics, tumor characteristics, and use of preoperative neoadjuvant therapy were retrieved.
  • Group A and Group B patients were similar with respect to age (P = 0.1), gender (P = 0.7), grade (P = 0.4), and stage of disease (P = 0.5).
  • [MeSH-major] Adenocarcinoma / surgery. Perineum / surgery. Rectal Neoplasms / surgery. Wound Healing

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  • (PMID = 19934916.001).
  • [ISSN] 1530-0358
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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45. Menkarios C, Azria D, Laliberté B, Moscardo CL, Gourgou S, Lemanski C, Dubois JB, Aillères N, Fenoglietto P: Optimal organ-sparing intensity-modulated radiation therapy (IMRT) regimen for the treatment of locally advanced anal canal carcinoma: a comparison of conventional and IMRT plans. Radiat Oncol; 2007;2:41
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  • [Title] Optimal organ-sparing intensity-modulated radiation therapy (IMRT) regimen for the treatment of locally advanced anal canal carcinoma: a comparison of conventional and IMRT plans.
  • BACKGROUND: To compare the dosimetric advantage of three different intensity-modulated radiation therapy (IMRT) plans to a three dimensional (3D) conventional radiation treatment for anal cancer with regards to organs-at-risk (OAR) avoidance, including iliac bone marrow.
  • METHODS: Five patients with T1-3 N0-1 anal cancer and five with T4 and/or N2-3 tumors were selected.
  • Clinical tumor volume (CTV) included tumor, anal canal and inguinal, peri-rectal, and internal/external iliac nodes (plus pre-sacral nodes for T4/N2-3 tumors).
  • CONCLUSION: IMRT is superior to 3D conformal radiation treatment for anal carcinoma with respect to OAR sparing, including bone marrow sparing.

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  • (PMID = 18005443.001).
  • [ISSN] 1748-717X
  • [Journal-full-title] Radiation oncology (London, England)
  • [ISO-abbreviation] Radiat Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2204019
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46. Patel HS, Silver AR, Levine T, Williams G, Northover JM: Human papillomavirus infection and anal dysplasia in renal transplant recipients. Br J Surg; 2010 Nov;97(11):1716-21
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  • [Title] Human papillomavirus infection and anal dysplasia in renal transplant recipients.
  • BACKGROUND: Immunosuppression is a known risk factor for anal human papillomavirus (HPV) disease, including anal squamous cell carcinoma.
  • Additional risk factors for HPV-related disease have not been studied in the renal transplant population.
  • The demographics of anal HPV and associated risk factors were investigated in this population.
  • METHODS: Anal cytology and polymerase chain reaction were used to assess anal HPV disease in a cohort of transplant recipients at the Royal London Hospital.
  • Risk factors associated with increased immunosuppression and HPV exposure were collated to determine any association with anal disease.
  • RESULTS: Anal dysplasia was associated with anal oncogenic HPV infection (P < 0.001), duration of immunosuppression (P = 0.050), previous genital warts (P = 0.018) and receptive anal intercourse (P = 0.013).
  • CONCLUSION: Anal dysplasia was related to immunosuppression and patient factors in this cohort.
  • [MeSH-major] Anal Canal / pathology. Anus Neoplasms / etiology. Carcinoma, Squamous Cell / etiology. Immunosuppression / adverse effects. Kidney Transplantation. Papillomavirus Infections / complications

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  • [Copyright] Copyright © 2010 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
  • (PMID = 20730855.001).
  • [ISSN] 1365-2168
  • [Journal-full-title] The British journal of surgery
  • [ISO-abbreviation] Br J Surg
  • [Language] eng
  • [Grant] United Kingdom / Cancer Research UK / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 9007-49-2 / DNA
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47. Ekwueme DU, Chesson HW, Zhang KB, Balamurugan A: Years of potential life lost and productivity costs because of cancer mortality and for specific cancer sites where human papillomavirus may be a risk factor for carcinogenesis-United States, 2003. Cancer; 2008 Nov 15;113(10 Suppl):2936-45
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  • The authors estimated the mortality-related burden (in terms of YPLL and productivity costs) of HPV-associated cancers (without regard to the percentage of each of these cancers that could be attributed to HPV) and all malignant cancers in the United States in 2003.
  • METHODS: The authors used 2003 national mortality data and US life tables to estimate YPLL for HPV-associated cancers and all malignant cancers.
  • The human capital approach was used to estimate the value of the expected future lifetime productivity losses caused by premature deaths from HPV-associated cancers and all malignant cancers.
  • RESULTS: In 2003, HPV-associated cancers accounted for 181,026 YPLL, which represented 2.4% of the estimated 7.5 million YPLL attributable to all malignant cancers in the United States.
  • The average number of YPLL was 21.8 per HPV-associated cancer death and 16.3 per death from overall malignant cancers.
  • The lifetime productivity cost from mortality in 2003 was $3.7 billion for HPV-associated cancer mortality and $133.5 billion for overall malignant cancer mortality.
  • [MeSH-major] Cost of Illness. Genital Neoplasms, Female / economics. Genital Neoplasms, Female / mortality. Papillomavirus Infections / complications
  • [MeSH-minor] Adolescent. Adult. Aged. Anus Neoplasms / economics. Anus Neoplasms / mortality. Efficiency. Female. Humans. Life Expectancy. Male. Middle Aged. Mouth Neoplasms / economics. Mouth Neoplasms / mortality. Neoplasms / economics. Neoplasms / mortality. Oropharyngeal Neoplasms / economics. Oropharyngeal Neoplasms / mortality. Penile Neoplasms / economics. Penile Neoplasms / mortality. Risk Factors. United States

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  • (PMID = 18980277.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Grant] United States / NCCDPHP CDC HHS / DP / U50 DP424071-04
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
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48. Gupta D, Jain R, Mishra S, Kumar S, Thulkar S, Bhatnagar S: Ultrasonography reinvents the originally described technique for ganglion impar neurolysis in perianal cancer pain. Anesth Analg; 2008 Oct;107(4):1390-2
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  • We present a patient diagnosed with carcinoma of the anal canal who was successfully given ultrasound-guided ganglion impar block using a Chiba needle inserted through the anococcygeal ligament.
  • [MeSH-major] Anal Canal. Anus Neoplasms / complications. Autonomic Nerve Block / methods. Ganglia, Sympathetic / surgery. Pain, Intractable / therapy. Ultrasonography, Interventional

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  • [CommentIn] Anesth Analg. 2009 Jun;108(6):1995; author reply 1995-6 [19448244.001]
  • [RetractionIn] Bhatnagar S. Anesth Analg. 2010 Dec;111(6):1560 [21106972.001]
  • (PMID = 18806057.001).
  • [ISSN] 1526-7598
  • [Journal-full-title] Anesthesia and analgesia
  • [ISO-abbreviation] Anesth. Analg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Retracted Publication
  • [Publication-country] United States
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49. Wang QG, Lu LF, Zhou YB, Cao SG, Wang DS, Lv L: [Effects of intensive insulin therapy on insulin resistance and serum proteins after radical gastrectomy]. Zhonghua Wei Chang Wai Ke Za Zhi; 2008 Sep;11(5):444-7
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  • RESULTS: (1)The levels of FBG, FINS, lnHOMA-IR (P<0.01,P<0.05) and the incidence of insulin resistance were remarkably decreased by intensive insulin therapy after the surgical procedure.(2)The levels of serum transferrin (TRF), prealbumin (PRE) and retinal binding protein (RBP) in the intensive insulin therapy group were significantly improved as compared to control group after operation(P<0.05). (3) The duration of fever, antibiotic use, passage of gas by anus, length of hospital stay and the occurrence of postoperative complications were also significantly lower than those in control group(P<0.01,P<0.05).
  • [MeSH-major] Blood Proteins / metabolism. Insulin / therapeutic use. Insulin Resistance. Stomach Neoplasms / drug therapy. Stomach Neoplasms / metabolism

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  • (PMID = 18803046.001).
  • [ISSN] 1671-0274
  • [Journal-full-title] Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
  • [ISO-abbreviation] Zhonghua Wei Chang Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Blood Glucose; 0 / Blood Proteins; 0 / Insulin
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50. Lepère C, Rakotomalala S, Maindrault-Goebel F, Mitry E, Vaillant JN, Julie C, Otmezguine Y, Rougier P: [Conservative treatment undifferentiated neuroendocrine tumors of the anal canal: two cases]. Gastroenterol Clin Biol; 2007 Apr;31(4):445-7
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  • [Title] [Conservative treatment undifferentiated neuroendocrine tumors of the anal canal: two cases].
  • [Transliterated title] Traitement conservateur des tumeurs endocrines peu différenciées du canal anal.
  • Undifferentiated neuroendocrine tumors are rare, and are characteristically aggressive with a poor prognosis.
  • Most patients have metastatic disease at diagnosis, and cannot undergo curative surgical treatment.
  • We report two cases of poorly differentiated neuroendocrine tumors localized in the anal canal and treated by chemotherapy and radiotherapy resulting in prolonged complete local remission and preventing extended surgical excision.
  • [MeSH-major] Anus Neoplasms / therapy. Brain Neoplasms / secondary. Neuroendocrine Tumors / therapy
  • [MeSH-minor] Adrenal Cortex Hormones / therapeutic use. Aged. Anal Canal / pathology. Antineoplastic Agents / administration & dosage. Antineoplastic Agents / therapeutic use. Antineoplastic Agents, Phytogenic / administration & dosage. Antineoplastic Agents, Phytogenic / therapeutic use. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biopsy. Cisplatin / administration & dosage. Cisplatin / therapeutic use. Combined Modality Therapy. Etoposide / administration & dosage. Etoposide / therapeutic use. Female. Follow-Up Studies. Humans. Male. Radiotherapy Dosage. Remission Induction. Time Factors

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  • (PMID = 17483787.001).
  • [ISSN] 0399-8320
  • [Journal-full-title] Gastroentérologie clinique et biologique
  • [ISO-abbreviation] Gastroenterol. Clin. Biol.
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Adrenal Cortex Hormones; 0 / Antineoplastic Agents; 0 / Antineoplastic Agents, Phytogenic; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin
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51. Samalavicius NE, Rudinskaite G, Pavalkis D, Latkauskas T, Kaselis N, Sidlauskas Z, Sniuolis P, Poskus T, Kvedaras V, Strupas K, Poskus E: [Laparoscopic surgery for malignancies of the colon, rectum, and anus in Lithuania in 2008]. Medicina (Kaunas); 2009;45(6):447-51
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  • [Title] [Laparoscopic surgery for malignancies of the colon, rectum, and anus in Lithuania in 2008].
  • THE OBJECTIVE OF THIS STUDY: was to analyze data on laparoscopic surgery for malignant diseases of the colon, rectum, and anus in Lithuania during the period of January 1, 2005, to February 15, 2008.
  • MATERIAL AND METHODS: During the above-mentioned period in Lithuania, 130 laparoscopic surgeries for malignancies of colon, rectum, and anus were performed in seven different hospitals.
  • Twenty-seven (20.8%) patients had stage I, 45 (34.6%) stage II, 45 (34.6%) stage III, and 13 (10%) stage IV disease.
  • CONCLUSIONS: Laparoscopic surgery for malignant diseases of the colon, rectum, and anus is dominating among laparoscopic surgeries for colorectum.
  • To evaluate disease relapse and outcomes, observation time is not sufficient yet.
  • [MeSH-major] Anus Neoplasms / surgery. Colonic Neoplasms / surgery. Laparoscopy. Rectal Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Anal Canal / pathology. Colon / pathology. Female. Humans. Length of Stay. Lithuania. Male. Middle Aged. Multicenter Studies as Topic. Neoplasm Staging. Postoperative Complications. Randomized Controlled Trials as Topic. Rectum / pathology. Reoperation. Time Factors

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  • (PMID = 19605964.001).
  • [ISSN] 1648-9144
  • [Journal-full-title] Medicina (Kaunas, Lithuania)
  • [ISO-abbreviation] Medicina (Kaunas)
  • [Language] lit
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Lithuania
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52. Salvans Ruiz S, Gimeno Beltrán J, Parés D: Perianal leiomyoma. Rev Esp Enferm Dig; 2009 Mar;101(3):209-11
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  • [MeSH-major] Anus Neoplasms. Leiomyoma

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  • (PMID = 19388801.001).
  • [ISSN] 1130-0108
  • [Journal-full-title] Revista española de enfermedades digestivas : organo oficial de la Sociedad Española de Patología Digestiva
  • [ISO-abbreviation] Rev Esp Enferm Dig
  • [Language] eng; spa
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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53. Yamamoto S, Fukunaga M, Miyajima N, Okuda J, Konishi F, Watanabe M, Japan Society of Laparoscopic Colorectal Surgery: Impact of conversion on surgical outcomes after laparoscopic operation for rectal carcinoma: a retrospective study of 1,073 patients. J Am Coll Surg; 2009 Mar;208(3):383-9
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  • STUDY DESIGN: A total of 1,073 patients with carcinoma of the rectum and anus who underwent laparoscopic operations were reviewed retrospectively.
  • [MeSH-major] Digestive System Surgical Procedures. Laparoscopy. Rectal Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Anal Canal / surgery. Body Mass Index. Female. Humans. Intraoperative Complications / classification. Intraoperative Complications / epidemiology. Intraoperative Complications / etiology. Length of Stay. Male. Middle Aged. Multivariate Analysis. Neoplasm Staging. Postoperative Complications / classification. Postoperative Complications / epidemiology. Postoperative Complications / etiology. Postoperative Hemorrhage / epidemiology. Retrospective Studies. Risk Factors. Treatment Outcome

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  • (PMID = 19318000.001).
  • [ISSN] 1879-1190
  • [Journal-full-title] Journal of the American College of Surgeons
  • [ISO-abbreviation] J. Am. Coll. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Investigator] Watanabe M; Kokuba Y; Konishi F; Kawamura Y; Miyajima N; Fukunaga M; Kudo S; Tanaka J; Tanigawa N; Okuda J; Nagai H; Otsuka K; Fukunaga Y; Okajima M; Bandou H; Kitano S; Inomata M; Kubo Y; Ichihara T; Hasegawa H; Yamamoto S; Ikoma S; Nishiyama Y; Sugihara K; Yamaguchi S; Sekimoto M; Masaki M; Idani H; Sumiyama Y; Saida Y; Munemoto Y; Maeda K; Hanai K; Kuroyanagi H; Ueda K
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54. Chang SC, Ke TW, Chiang HC, Wu C, Chen WT: Laparoscopic excision is an alterative method for rectal gastrointestinal stromal tumor. Surg Laparosc Endosc Percutan Tech; 2010 Aug;20(4):284-7
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  • [Title] Laparoscopic excision is an alterative method for rectal gastrointestinal stromal tumor.
  • Gastrointestinal stromal tumors (GISTs) are rarely found in the anorectum and account for less than 0.3% of all rectal malignancies.
  • The major treatment of rectal GISTs is complete resection of the primary tumor with negative microscopic margin.
  • The tumor was mobilized by laparoscopic dissection with a clear safe margin and the specimen was removed from anus.
  • [MeSH-major] Gastrointestinal Stromal Tumors / surgery. Laparoscopy. Rectal Neoplasms / surgery

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  • (PMID = 20729704.001).
  • [ISSN] 1534-4908
  • [Journal-full-title] Surgical laparoscopy, endoscopy & percutaneous techniques
  • [ISO-abbreviation] Surg Laparosc Endosc Percutan Tech
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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55. Wang YY, Lin SY, Lai WA, Liu PH, Sheu WH: Association between adenomas of rectosigmoid colon and metabolic syndrome features in a Chinese population. J Gastroenterol Hepatol; 2005 Sep;20(9):1410-5
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  • All patients underwent a sigmoidoscopic examination to 60 cm from the anus.
  • Pathological findings were hyperplastic in 138 subjects, adenomas in 341, carcinomas in 10, and other benign lesions in 79.
  • [MeSH-major] Adenoma / complications. Metabolic Syndrome X / complications. Rectal Neoplasms / complications. Sigmoid Neoplasms / complications

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  • [Copyright] Copyright 2005 Blackwell Publishing Asia Pty Ltd.
  • (PMID = 16105129.001).
  • [ISSN] 0815-9319
  • [Journal-full-title] Journal of gastroenterology and hepatology
  • [ISO-abbreviation] J. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
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56. de Parades V: [Anal pathology: undeniable progress made]. Rev Prat; 2008 Oct 31;58(16):1751-3
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  • [Title] [Anal pathology: undeniable progress made].
  • [Transliterated title] Pathologie anale. Des progrès indéniables.
  • [MeSH-major] Anus Diseases. Colorectal Surgery / trends
  • [MeSH-minor] Anus Neoplasms / epidemiology. Carcinoma, Squamous Cell / epidemiology. Fissure in Ano / epidemiology. France / epidemiology. Hemorrhoids / epidemiology. Humans. Prevalence. Rectal Fistula / epidemiology. Sex Factors

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  • (PMID = 19143145.001).
  • [ISSN] 0035-2640
  • [Journal-full-title] La Revue du praticien
  • [ISO-abbreviation] Rev Prat
  • [Language] fre
  • [Publication-type] Journal Article
  • [Publication-country] France
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57. Lee YT: Improve anorectal examination by the cap-assisted colonoscopy method. Gastrointest Endosc; 2010 Feb;71(2):433
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Capsule Endoscopy / methods. Colonoscopy / adverse effects. Colonoscopy / methods. Intestinal Perforation / prevention & control. Rectal Neoplasms / diagnosis
  • [MeSH-minor] Anus Neoplasms / diagnosis. Capsule Endoscopes. Cohort Studies. Female. Humans. Male. Pain Measurement. Proctoscopy / adverse effects. Proctoscopy / methods. Total Quality Management

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  • [CommentOn] Gastrointest Endosc. 2009 Apr;69(4):960-3 [19327487.001]
  • (PMID = 20152327.001).
  • [ISSN] 1097-6779
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Comment; Comparative Study; Letter
  • [Publication-country] United States
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58. Glynne-Jones R, Northover J, Oliveira J, ESMO Guidelines Working Group: Anal cancer: ESMO clinical recommendations for diagnosis, treatment and follow-up. Ann Oncol; 2009 May;20 Suppl 4:57-60
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  • [Title] Anal cancer: ESMO clinical recommendations for diagnosis, treatment and follow-up.

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  • (PMID = 19454464.001).
  • [ISSN] 1569-8041
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 12
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59. Matsuo K, Hew KE, Im DD, Rosenshein NB: Clitoral metastasis of anal adenocarcinoma associated with rectovaginal fistula in long standing Crohn's disease. Eur J Obstet Gynecol Reprod Biol; 2009 Jun;144(2):182-3
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  • [Title] Clitoral metastasis of anal adenocarcinoma associated with rectovaginal fistula in long standing Crohn's disease.
  • [MeSH-major] Adenocarcinoma, Mucinous / secondary. Anus Neoplasms / pathology. Clitoris / pathology. Crohn Disease / complications. Rectovaginal Fistula / complications. Vulvar Neoplasms / secondary


60. De Vuyst H, Clifford GM, Nascimento MC, Madeleine MM, Franceschi S: Prevalence and type distribution of human papillomavirus in carcinoma and intraepithelial neoplasia of the vulva, vagina and anus: a meta-analysis. Int J Cancer; 2009 Apr 1;124(7):1626-36
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  • [Title] Prevalence and type distribution of human papillomavirus in carcinoma and intraepithelial neoplasia of the vulva, vagina and anus: a meta-analysis.
  • This meta-analysis investigated human papillomavirus (HPV) prevalence in vulvar, vaginal and anal intraepithelial neoplasia (VIN, VAIN, AIN) grades 1-3 and carcinoma from 93 studies conducted in 4 continents and using PCR assays.
  • Overall HPV prevalence was 67.8%, 85.3% and 40.4% among 90 VIN1, 1,061 VIN2/3 and 1,873 vulvar carcinomas; 100%, 90.1% and 69.9% among 107 VAIN1, 191 VAIN2/3 and 136 vaginal carcinomas; and 91.5%, 93.9% and 84.3% among 671 AIN1, 609 AIN2/3 and 955 anal carcinomas, respectively.
  • HPV16 was found more frequently (>75%) and HPV18 less frequently (<10%) in HPV-positive vulvar, vaginal and anal carcinomas than in cervical carcinoma.
  • HPV prevalence in anal carcinoma was higher among women (90.8%) than men (74.9%), but no difference by gender emerged in North America.
  • In conclusion, approximately 40% of vulvar, 60% of vaginal and 80% of anal carcinoma may be avoided by prophylactic vaccines against HPV16/18.
  • This proportion would be similar for the corresponding high-grade lesions of the vagina and anus, but higher for VIN2/3 (75%) than for vulvar carcinoma.
  • [MeSH-major] Anus Neoplasms / virology. Papillomavirus Infections / epidemiology. Vaginal Neoplasms / virology. Vulvar Neoplasms / virology


61. Harper DM: Prevention of human papillomavirus infections and associated diseases by vaccination: a new hope for global public health. Public Health Genomics; 2009;12(5-6):319-30
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  • There is a clinical hope, though, already supported by early data, that the vaccines are capable of neutralizing HPV virions in host tissues from both auto-inoculated infections and infections in other organs than the cervix, thereby making it possible for these vaccines to prevent less common HPV-associated cancers of the penis, vagina, vulva, anus, oral cavity and oro-pharynx.
  • [MeSH-minor] Adolescent. Adult. Drug Approval. Female. Humans. Randomized Controlled Trials as Topic. Time Factors. United States. Uterine Cervical Dysplasia / prevention & control. Uterine Cervical Dysplasia / virology. Uterine Cervical Neoplasms / genetics. Vaginal Diseases / prevention & control. Vaginal Diseases / virology. Vulvar Diseases / prevention & control. Vulvar Diseases / virology

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  • [Copyright] Copyright 2009 S. Karger AG, Basel.
  • (PMID = 19684444.001).
  • [ISSN] 1662-8063
  • [Journal-full-title] Public health genomics
  • [ISO-abbreviation] Public Health Genomics
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Cancer Vaccines; 0 / Papillomavirus Vaccines; 0 / human papillomavirus vaccine, L1 type 16, 18
  • [Number-of-references] 47
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62. Sgourakis G, Lanitis S, Karaliotas C: Clinical challenges and images in GI. Anal tumor with refractory hypercalcemia. Gastroenterology; 2010 May;138(5):1667, 2025
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  • [Title] Clinical challenges and images in GI. Anal tumor with refractory hypercalcemia.
  • [MeSH-major] Alphapapillomavirus / isolation & purification. Anus Diseases / virology. Anus Neoplasms / virology. Carcinoma, Squamous Cell / virology. Condylomata Acuminata / virology. Hypercalcemia / virology. Papillomavirus Infections / virology. Paraneoplastic Syndromes / virology

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  • (PMID = 20332041.001).
  • [ISSN] 1528-0012
  • [Journal-full-title] Gastroenterology
  • [ISO-abbreviation] Gastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Viral
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63. Fonseca IB, Spitale LS, Gramática L, Cejas H, Piccinni DJ, Ghirardi G: [Gastrointestinal stromal tumors: conceptual evolution]. Rev Fac Cien Med Univ Nac Cordoba; 2006;63(1):37-45
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  • [Title] [Gastrointestinal stromal tumors: conceptual evolution].
  • Gastrointestinal stromal tumors (GISTs) constitute the largest category of primary nonepithelial neoplasms of the stomach and small bowel.
  • They represent about 1-2% from all neoplasms of the digestive tract.
  • They occur most commonly in the stomach and small bowel, but small series of comparable tumors have also been reported in all the other parts of the tubular gastrointestinal tract, including esophagus, colon, rectum and anus.
  • Originally recognized in 1960 by Martin et. al. as a distinctive type of stromal neoplasm of the bowel, they were subsequently reported by Stout, who introduced the term leiomyoblastoma.
  • Because of difficulties in accurately predicting the biologic behavior of these tumors, the term "smooth muscle tumor of uncertain malignant potential" (SMTUMP) has been introduced for borderline tumors.
  • In 1983, Mazur and Clark coined the term gastrointestinal stromal tumor and suggested that these neoplasms might arise from the myenteric nervous system.
  • Some studies have reported evidence of neuronal cell differentiation in a proportion of GISTs and the term "gastrointestinal autonomic nerve tumor (GANT) has been introduced.
  • [MeSH-major] Gastrointestinal Stromal Tumors / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Neoplasm Invasiveness

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  • (PMID = 17639807.001).
  • [ISSN] 0014-6722
  • [Journal-full-title] Revista de la Facultad de Ciencias Médicas (Córdoba, Argentina)
  • [ISO-abbreviation] Rev Fac Cien Med Univ Nac Cordoba
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Argentina
  • [Number-of-references] 46
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64. Barriger RB, Johnstone PA: Advanced radiation technology in the treatment of anal cancer. Oncology (Williston Park); 2009 Nov 15;23(12):1096, 1098
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  • [Title] Advanced radiation technology in the treatment of anal cancer.
  • [MeSH-major] Anus Neoplasms / radiotherapy

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  • [CommentOn] Oncology (Williston Park). 2009 Nov 15;23(12):1082-9 [20017291.001]
  • (PMID = 20017293.001).
  • [ISSN] 0890-9091
  • [Journal-full-title] Oncology (Williston Park, N.Y.)
  • [ISO-abbreviation] Oncology (Williston Park, N.Y.)
  • [Language] eng
  • [Publication-type] Comment; Journal Article
  • [Publication-country] United States
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65. Hayanga AJ: HPV, cervical dysplasia and anal cancer screening--a need for liaison between gynecology and colorectal clinics. Gynecol Oncol; 2006 Sep;102(3):600-1
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  • [Title] HPV, cervical dysplasia and anal cancer screening--a need for liaison between gynecology and colorectal clinics.
  • [MeSH-major] Anus Neoplasms / virology. Cytodiagnosis. Papillomavirus Infections / diagnosis. Uterine Cervical Dysplasia / virology


66. Noé JE: L-glutamine use in the treatment and prevention of mucositis and cachexia: a naturopathic perspective. Integr Cancer Ther; 2009 Dec;8(4):409-15
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  • Mucositis is an intestinal mucosal damage of the gastrointestinal tract--mouth, throat, stomach, intestines, rectum, and anus--that is caused directly by chemotherapies and radiotherapies.
  • There has been some question as to the use of GLN in this patient population because of its role as a preferred energy source not only for enterocytes and lymphocytes but for malignant cells as well.This article will address the questions of safety, efficacy, dosing, and toxicity of GLN used as an integrative therapeutic in ongoing integrative cancer treatment.
  • [MeSH-minor] Administration, Oral. Animals. Antineoplastic Agents / adverse effects. Antineoplastic Agents / therapeutic use. Humans. Naturopathy. Neoplasms / drug therapy. Neoplasms / radiotherapy. Radiotherapy, Adjuvant / adverse effects. Stomatitis / drug therapy. Stomatitis / etiology. Stomatitis / prevention & control

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  • (PMID = 19942578.001).
  • [ISSN] 1552-695X
  • [Journal-full-title] Integrative cancer therapies
  • [ISO-abbreviation] Integr Cancer Ther
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Amino Acids; 0 / Antineoplastic Agents; 0RH81L854J / Glutamine
  • [Number-of-references] 39
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67. Vieillot S, Fenoglietto P, Moscardo CL, Aillères N, Lemanski C, Dubois JB, Azria D: [Which intensity modulated radiation therapy? From "step and shoot" to volumetric modulated arc therapy, point of view of the radiation oncologist]. Cancer Radiother; 2010 Oct;14(6-7):550-3
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  • [Transliterated title] Quelle radiothérapie conformationnelle avec modulation d'intensité? De la technique "step and shoot" à l'arcthérapie, point de vue de l'oncologue radiothérapeute.
  • Intensity modulated radiation therapy (IMRT) offers optimal dosimetric and clinical results in terms of acute toxicity, allows augmenting the dose to the target volumes and therefore, appears promising for local control and disease-free survival.
  • [MeSH-major] Neoplasms / radiotherapy. Radiation Oncology. Radiotherapy, Intensity-Modulated / methods
  • [MeSH-minor] Antineoplastic Agents, Hormonal / therapeutic use. Anus Neoplasms / radiotherapy. Clinical Trials as Topic. Combined Modality Therapy. Computer Systems. Cone-Beam Computed Tomography. Dose-Response Relationship, Radiation. Female. Genital Neoplasms, Female / radiotherapy. Humans. Intestines / radiation effects. Male. Neoplasms, Radiation-Induced / etiology. Neoplasms, Radiation-Induced / prevention & control. Neoplasms, Second Primary / etiology. Neoplasms, Second Primary / prevention & control. Prostatic Neoplasms / drug therapy. Prostatic Neoplasms / radiography. Prostatic Neoplasms / radiotherapy. Radiation Injuries / etiology. Radiation Injuries / prevention & control. Radiosurgery. Radiotherapy Dosage. Radiotherapy Planning, Computer-Assisted / methods. Risk. Urinary Bladder / radiation effects

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  • [Copyright] Copyright © 2010 Société française de radiothérapie oncologique (SFRO). Published by Elsevier SAS. All rights reserved.
  • (PMID = 20724189.001).
  • [ISSN] 1769-6658
  • [Journal-full-title] Cancer radiothérapie : journal de la Société française de radiothérapie oncologique
  • [ISO-abbreviation] Cancer Radiother
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Hormonal
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68. Pepek JM, Willett CG, Wu QJ, Yoo S, Clough RW, Czito BG: Intensity-modulated radiation therapy for anal malignancies: a preliminary toxicity and disease outcomes analysis. Int J Radiat Oncol Biol Phys; 2010 Dec 1;78(5):1413-9
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  • [Title] Intensity-modulated radiation therapy for anal malignancies: a preliminary toxicity and disease outcomes analysis.
  • PURPOSE: Intensity-modulated radiation therapy (IMRT) has the potential to reduce toxicities associated with chemoradiotherapy in the treatment of anal cancer.
  • This study reports the results of using IMRT in the treatment of anal cancer.
  • METHODS AND MATERIALS: Records of patients with anal malignancies treated with IMRT at Duke University were reviewed.
  • RESULTS: Forty-seven patients with anal malignancy (89% canal, 11% perianal skin) were treated with IMRT between August 2006 and September 2008.
  • CONCLUSIONS: IMRT-based chemoradiotherapy for anal cancer results in significant reductions in normal tissue dose and acute toxicities versus historic controls treated without IMRT, leading to reduced rates of toxicity-related treatment interruption.
  • Early disease-related outcomes seem encouraging.
  • IMRT is emerging as a standard therapy for anal cancer.
  • [MeSH-major] Anus Neoplasms / radiotherapy. Radiotherapy, Intensity-Modulated / adverse effects
  • [MeSH-minor] Adenocarcinoma / radiotherapy. Adolescent. Adult. Aged. Aged, 80 and over. Anemia / etiology. Carcinoma, Squamous Cell / radiotherapy. Diarrhea / etiology. Female. Humans. Leukopenia / etiology. Male. Melanoma / radiotherapy. Middle Aged. Neuroendocrine Tumors / radiotherapy. Radiotherapy Dosage. Rhabdomyosarcoma / radiotherapy. Sarcoma / radiotherapy. Thrombocytopenia / etiology. Treatment Outcome. Young Adult

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20231064.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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69. Schiller DE, Cummings BJ, Rai S, Le LW, Last L, Davey P, Easson A, Smith AJ, Swallow CJ: Outcomes of salvage surgery for squamous cell carcinoma of the anal canal. Ann Surg Oncol; 2007 Oct;14(10):2780-9
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  • [Title] Outcomes of salvage surgery for squamous cell carcinoma of the anal canal.
  • BACKGROUND: For patients with anal canal cancer who fail combined modality treatment (CMT), salvage surgery (SS) offers the potential for long term survival.
  • METHODS: We identified 60 patients with persistent or recurrent anal cancer who had undergone SS; 20 were excluded.
  • Overall and disease-free survival (OS, DFS) curves were constructed using the Kaplan Meier method.
  • Median OS was 41 months; OS and disease free survival at 5 years were 39% and 30%, respectively.
  • Independent predictors of poor OS were male gender, Charlson Comorbidity Score and tumor size.
  • Independent predictors of poor disease free survival were positive margins and lymphovascular invasion.
  • CONCLUSION: SS for anal canal cancer was associated with significant morbidity.
  • [MeSH-major] Anus Neoplasms / surgery. Carcinoma, Squamous Cell / surgery. Neoplasm Recurrence, Local / surgery. Neoplasm, Residual / surgery. Salvage Therapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Anal Canal / pathology. Anal Canal / surgery. Cancer Care Facilities. Combined Modality Therapy. Disease-Free Survival. Female. Follow-Up Studies. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Neoplasm Invasiveness / pathology. Neoplasm Staging. Ontario. Registries. Reoperation. Retrospective Studies

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  • (PMID = 17638059.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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70. Christian CK, Kwaan MR, Betensky RA, Breen EM, Zinner MJ, Bleday R: Risk factors for perineal wound complications following abdominoperineal resection. Dis Colon Rectum; 2005 Jan;48(1):43-8
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  • Patients with anal cancer had a higher rate of major complications than those with rectal cancer or inflammatory bowel disease.
  • Minor wound complications were more common in patients with anal cancer and inflammatory bowel disease than those with rectal cancer.
  • Factors associated with a higher rate of major wound complications included flap closure, tumor size, body mass index, diabetes, and indication for the procedure.
  • Patients with anal cancer and inflammatory bowel disease were at higher risk for perineal wound complications than those with rectal cancer.
  • [MeSH-major] Abdomen / surgery. Anus Neoplasms / surgery. Inflammatory Bowel Diseases / complications. Perineum / injuries. Perineum / surgery. Postoperative Complications
  • [MeSH-minor] Adult. Aged. Body Mass Index. Diabetes Complications. Female. Humans. Male. Middle Aged. Rectal Neoplasms / surgery. Retrospective Studies. Risk Factors

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  • (PMID = 15690656.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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71. O'Mahony C: Response to "Anoscopy could be beneficial for women with external anogenital condyloma". Eur J Obstet Gynecol Reprod Biol; 2007 Sep;134(1):137; author reply 138-40
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  • [MeSH-major] Alphapapillomavirus / pathogenicity. Anus Neoplasms / therapy. Condylomata Acuminata / therapy. Self Medication / adverse effects

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  • [CommentOn] Eur J Obstet Gynecol Reprod Biol. 2007 Jul;133(1):121-2 [17314001.001]
  • (PMID = 17343975.001).
  • [ISSN] 0301-2115
  • [Journal-full-title] European journal of obstetrics, gynecology, and reproductive biology
  • [ISO-abbreviation] Eur. J. Obstet. Gynecol. Reprod. Biol.
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] Ireland
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72. Alvarez-Moret J, Dirscherl T, Rickhey M, Bogner L: Improving the performance of direct Monte Carlo optimization for large tumor volumes. Z Med Phys; 2010;20(3):197-205
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  • [Title] Improving the performance of direct Monte Carlo optimization for large tumor volumes.
  • In the present work, we applied a combination of both techniques to optimize an anal cancer case.
  • Therefore, SDDT was applied to the anal cancer case.
  • After optimization with DMCO using one segment per beam, a final dose calculation with 2% variance was performed.
  • In this way, the DMCO optimization with qIMAT of complex cases with large treatment volumes, such as anal cancer, are possible.
  • Furthermore, for anal cancer, the comparison of qIMAT with IMRT showed that qIMAT can improve the plan quality.
  • [MeSH-major] Monte Carlo Method. Neoplasms / pathology. Neoplasms / radiotherapy. Phantoms, Imaging. Prostatic Neoplasms / radiotherapy. Radiotherapy Planning, Computer-Assisted / methods
  • [MeSH-minor] Algorithms. Anus Neoplasms / pathology. Anus Neoplasms / radiotherapy. Child. Humans. Intestine, Small / radiation effects. Male. Radiotherapy Dosage

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  • [Copyright] Copyright © 2010. Published by Elsevier GmbH.
  • (PMID = 20832007.001).
  • [ISSN] 0939-3889
  • [Journal-full-title] Zeitschrift für medizinische Physik
  • [ISO-abbreviation] Z Med Phys
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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73. Bruna A, Gastelblum P, Thomas L, Chapet O, Bollet MA, Ardiet JM, Gérard JP, Peiffert D: Treatment of squamous cell anal canal carcinoma (SCACC) with pulsed dose rate brachytherapy: a retrospective study. Radiother Oncol; 2006 Apr;79(1):75-9
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  • [Title] Treatment of squamous cell anal canal carcinoma (SCACC) with pulsed dose rate brachytherapy: a retrospective study.
  • [MeSH-major] Anus Neoplasms / radiotherapy. Brachytherapy / methods. Carcinoma, Squamous Cell / radiotherapy

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  • (PMID = 16631268.001).
  • [ISSN] 0167-8140
  • [Journal-full-title] Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
  • [ISO-abbreviation] Radiother Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] Ireland
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74. Starac D, Brestovac B, Sterrett GF, Smith DW, Frost FA: Can HPV DNA testing on FNA material determine anogenital origin in metastatic squamous cell carcinoma? Pathology; 2005 Jun;37(3):197-203
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  • The aim of this study was to examine whether the finding of HR HPV DNA in a fine needle aspiration (FNA) of metastatic SCC could be used to determine a likely anogenital origin.
  • The positive control case was an oral cavity tumour and type 33 was sequenced.
  • HPV DNA detection was the major indicator to the primary site in one occult tumour and several where the previous diagnosis of anogenital cancer was not known at presentation.
  • [MeSH-major] Anus Neoplasms / virology. Carcinoma, Squamous Cell / virology. DNA, Viral / analysis. Papillomaviridae / genetics. Tumor Virus Infections / diagnosis. Urogenital Neoplasms / virology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biopsy, Fine-Needle. Female. Humans. Male. Middle Aged. Oncogenic Viruses / genetics. Papillomavirus Infections / diagnosis. Polymerase Chain Reaction


75. Kreuter A, Potthoff A, Brockmeyer NH, Gambichler T, Swoboda J, Stücker M, Schmitt M, Pfister H, Wieland U, German Competence Network HIV/AIDS: Anal carcinoma in human immunodeficiency virus-positive men: results of a prospective study from Germany. Br J Dermatol; 2010 Jun;162(6):1269-77
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  • [Title] Anal carcinoma in human immunodeficiency virus-positive men: results of a prospective study from Germany.
  • BACKGROUND: Anal intraepithelial neoplasia (AIN), a human papillomavirus (HPV)-associated potential precursor lesion of anal cancer, is frequent among human immunodeficiency virus (HIV)-positive men who have sex with men (MSM).
  • There is a paucity of data published on the progression of high-grade AIN to invasive cancer as well as on clinical and virological characteristics comparing anal margin and anal canal carcinoma.
  • OBJECTIVES: To search for anal carcinoma and AIN in a large series of HIV-positive MSM, to assess treatment response of anal carcinoma, and to analyse lesional HPV spectrum of anal cancers.
  • METHODS: Detection of anal carcinoma and AIN was performed using cytology, high-resolution anoscopy, and histology in case of abnormal findings.
  • Additionally, HPV analyses for 36 high- and low-risk α-HPV types were performed in patients with anal carcinoma.
  • Of these, 116 (26·0%) patients had normal findings, 163 (36·5%) had low-grade AIN, 156 (35·0%) had high-grade AIN, and 11 (2·5%) had anal carcinoma as evidenced by the highest grade of cytology/histology.
  • Five patients with anal cancer, who had refused treatment of their precancerous lesions, had progressed from high-grade AIN to invasive cancer within a median time of 8·6 months.
  • All anal cancers carried high-risk α-HPV types.
  • All five squamous cell carcinomas (SCCs) of the anal canal were HPV16 positive.
  • In contrast, only one of the four anal margin SCCs were HPV16 positive (HPV31, HPV33 and HPV33 + HPV68 were found in the other three anal margin SCCs).
  • In contrast to the cancer biopsies, a broad spectrum of surface high- and low-risk HPV types was found in anal swabs of the patients.
  • Surgical excision resulted in long-term disease control of all anal margin carcinomas, whereas combined chemoradiotherapy in carcinomas of the anal canal was associated with high recurrence rates, high toxicity, and high mortality.
  • CONCLUSIONS: Anal carcinoma and AIN are frequent in HIV-positive men, even in patients participating in anal cancer prevention programmes.
  • Anal margin carcinoma and anal canal carcinoma differ substantially in their lesional HPV spectrum, prognosis and treatment response.
  • [MeSH-major] Anus Neoplasms / virology. Carcinoma in Situ / virology. Carcinoma, Squamous Cell / virology. HIV Seropositivity / complications. Papillomaviridae / isolation & purification

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  • [Copyright] © 2010 The Authors. Journal Compilation © 2010 British Association of Dermatologists.
  • (PMID = 20184584.001).
  • [ISSN] 1365-2133
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Databank-accession-numbers] ClinicalTrials.gov/ NCT00365729
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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76. Carroll KA, Pierce J, Kovarik CL: Perianal Bowen disease in a child with human immunodeficiency virus. Pediatr Dermatol; 2010 Mar-Apr;27(2):166-9
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  • [Title] Perianal Bowen disease in a child with human immunodeficiency virus.
  • We report a case of perianal Bowen disease in an HIV-positive child.
  • [MeSH-major] Anus Neoplasms / virology. Bowen's Disease / virology. Carcinoma in Situ / virology. Carcinoma, Squamous Cell / virology. HIV Infections / complications. Papillomavirus Infections / etiology. Skin Neoplasms / virology

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  • (PMID = 20537068.001).
  • [ISSN] 1525-1470
  • [Journal-full-title] Pediatric dermatology
  • [ISO-abbreviation] Pediatr Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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77. Kobayashi H, Ueno H, Hashiguchi Y, Ishiguro M, Omata J, Kajiwara Y, Shimazaki H, Mochizuki H: T1 neuroendocrine carcinoma of anal canal after transanal resection for intramucosal adenocarcinoma. Jpn J Clin Oncol; 2006 May;36(5):325-8
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  • [Title] T1 neuroendocrine carcinoma of anal canal after transanal resection for intramucosal adenocarcinoma.
  • Neuroendocrine carcinomas of the anal canal are rare, representing 1% of malignant tumors of the anal canal.
  • This tumor behaves aggressively and leads to poor outcomes.
  • The majority of tumors are found with distant metastases.
  • We describe the case of a 63-year-old female with T1 neuroendocrine carcinoma of the anal canal arising from the site of a previous transanal excision performed 13 months earlier for intramucosal adenocarcinoma of the anal canal.
  • In this case, it is likely that the neuroendocrine tumor, which infiltrated into the submucosal layer with venous invasion, had developed over the intervening 13 months following the original transanal excision of the adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / surgery. Anal Canal / surgery. Anus Neoplasms / etiology. Carcinoma, Neuroendocrine / etiology. Neoplasm Recurrence, Local
  • [MeSH-minor] Female. Humans. Middle Aged. Neoplasm Invasiveness

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  • (PMID = 16702164.001).
  • [ISSN] 0368-2811
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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78. Gingelmaier A, Weissenbacher T, Kost B, Kaestner R, Sovric M, Mylonas I, Friese K, Bergauer F: Anal cytology as a screening tool for early detection of anal dysplasia in HIV-infected women. Anticancer Res; 2010 May;30(5):1719-23
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  • [Title] Anal cytology as a screening tool for early detection of anal dysplasia in HIV-infected women.
  • BACKGROUND AND AIM: HIV-infected patients show a high rate of anal dysplasia and anal carcinoma but there is no gold standard for early detection.
  • Therefore, the objectives of this prospective study were: a) evaluation of an anal screening using anal/perianal cytology;.
  • PATIENTS AND METHODS: In every HIV-infected woman visiting our gynaecological outpatient clinic, an anal and perianal swab for anal cytology was taken.
  • The results of 13 (13.5%) anal cytologies were classified as suspicious for low-grade or high-grade anal dysplasia and 6 of these were confirmed in an anal biopsy.
  • CONCLUSION: In this pilot study, anal screening using anal cytology showed 13.5% suspected anal dysplasia in HIV-infected women.
  • All performed biopsies revealed the presence of a high-grade anal lesion.
  • The majority of these women already had an advanced disease and/or immune defect related to their HIV infection.
  • In summary, we found anal cytology to be a useful tool to early detect anal dysplasia of high-risk patients such as HIV-infected women.
  • How far this screening method contributes to the prevention of anal cancer has to be evaluated in further investigations.
  • [MeSH-major] Anal Canal / pathology. Anus Diseases / diagnosis. Anus Diseases / virology. Anus Neoplasms / diagnosis. Cytological Techniques / methods. HIV Infections / complications. HIV Infections / virology
  • [MeSH-minor] Adult. Biopsy. Cohort Studies. Female. Humans. Immune System. Middle Aged. Papillomavirus Infections / complications. Papillomavirus Infections / diagnosis. Papillomavirus Infections / virology. Prospective Studies. Uterine Cervical Neoplasms / complications. Uterine Cervical Neoplasms / diagnosis. Uterine Cervical Neoplasms / virology


79. Widder J, Kastenberger R, Fercher E, Schmid R, Langendijk JA, Dobrowsky W, Pötter R: Radiation dose associated with local control in advanced anal cancer: retrospective analysis of 129 patients. Radiother Oncol; 2008 Jun;87(3):367-75
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  • [Title] Radiation dose associated with local control in advanced anal cancer: retrospective analysis of 129 patients.
  • BACKGROUND AND PURPOSE: To retrospectively analyse a large consecutive cohort of patients with anal cancer for treatment-related factors influencing local control and survival.
  • MATERIALS AND METHODS: All patients referred for primary radiotherapy at Medical University of Vienna in 1990-2002 with anal canal carcinoma without distant metastases were analysed.
  • Patient-, tumour-, and treatment-factors were tested for influence on survival and local control using Cox multivariate analysis.
  • With median follow-up of 8.0 years for surviving patients (3.9 years including deceased patients), five-year overall survival and disease-free-survival were 57% and 51%, respectively.
  • Stage and age were significant factors for overall and colostomy-free-survival, N-stage for disease-free-survival.
  • CONCLUSIONS: These results support potential improvement of anal cancer treatment by studying advanced technology such as IMRT, making it possible to tailor high-dose regions.
  • [MeSH-major] Anus Neoplasms / radiotherapy. Carcinoma, Squamous Cell / radiotherapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Combined Modality Therapy. Disease-Free Survival. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Radiotherapy Dosage. Survival Rate

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  • (PMID = 18501453.001).
  • [ISSN] 0167-8140
  • [Journal-full-title] Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
  • [ISO-abbreviation] Radiother Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
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80. Chen SY, Takeuchi S, Moroi Y, Hayashida S, Kido M, Uchi H, Takahara M, Uenotsuchi T, Tu YT, Urabe K, Furue M: Concordant over-expression of transcription factor Sp1 and vascular endothelial growth factor in extramammary Paget's disease. Int J Dermatol; 2008 Jun;47(6):562-6
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  • [Title] Concordant over-expression of transcription factor Sp1 and vascular endothelial growth factor in extramammary Paget's disease.
  • But the expression of Sp1 and VEGF has not previously been investigated in extramammary Paget's disease (EMPD).
  • METHODS: To investigate the expression of Sp1 and VEGF proteins in EMPD and to assess their relationships and potential contribution to malignant transduction of EMPD, paraffin-embedded EMPD specimens (35 tissue samples from 33 patients with primary EMPD, including two samples of metastatic lymph nodes from two patients) were subjected to immunohistochemical staining for Sp1 and VEGF.
  • CONCLUSIONS: The present study reveals that the concordant over-expression of Sp1 and VEGF may play a pivotal role in the tumorigenesis and further malignant transduction of EMPD.
  • [MeSH-major] Neoplasm Proteins / metabolism. Paget Disease, Extramammary / metabolism. Skin Neoplasms / metabolism. Sp1 Transcription Factor / metabolism. Urogenital Neoplasms / metabolism. Vascular Endothelial Growth Factor A / metabolism
  • [MeSH-minor] Aged. Aged, 80 and over. Anus Neoplasms / metabolism. Anus Neoplasms / pathology. Axilla / pathology. Female. Humans. Immunohistochemistry. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Invasiveness. Skin / metabolism. Skin / pathology

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  • (PMID = 18477144.001).
  • [ISSN] 1365-4632
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Neoplasm Proteins; 0 / Sp1 Transcription Factor; 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A
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81. Wu J, Rosenbaum E, Begum S, Westra WH: Distribution of BRAF T1799A(V600E) mutations across various types of benign nevi: implications for melanocytic tumorigenesis. Am J Dermatopathol; 2007 Dec;29(6):534-7
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  • [Title] Distribution of BRAF T1799A(V600E) mutations across various types of benign nevi: implications for melanocytic tumorigenesis.
  • Its ubiquitous presence suggests that it poses no significant threat of malignant transformation, raising doubts about its relevance in melanoma development and its suitability as a target of directed therapy in patients with melanoma.
  • [MeSH-major] Melanocytes / pathology. Mutation. Nevus / genetics. Proto-Oncogene Proteins B-raf / genetics. Skin Neoplasms / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Anus Neoplasms / genetics. Anus Neoplasms / pathology. Anus Neoplasms / surgery. Back / pathology. Child. DNA Mutational Analysis. DNA, Neoplasm / analysis. Extremities / pathology. Female. Head and Neck Neoplasms / genetics. Head and Neck Neoplasms / pathology. Head and Neck Neoplasms / surgery. Humans. Male. Microdissection. Middle Aged. Urogenital Neoplasms / genetics. Urogenital Neoplasms / pathology. Urogenital Neoplasms / surgery

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  • (PMID = 18032947.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf
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82. Palefsky J: Can HPV vaccination help to prevent anal cancer? Lancet Infect Dis; 2010 Dec;10(12):815-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Can HPV vaccination help to prevent anal cancer?
  • [MeSH-major] Anus Neoplasms / prevention & control. Anus Neoplasms / virology. Papillomaviridae / immunology. Papillomavirus Infections / prevention & control. Papillomavirus Vaccines / administration & dosage

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  • [CommentOn] Lancet Infect Dis. 2010 Dec;10(12):845-52 [21051295.001]
  • (PMID = 21051294.001).
  • [ISSN] 1474-4457
  • [Journal-full-title] The Lancet. Infectious diseases
  • [ISO-abbreviation] Lancet Infect Dis
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Papillomavirus Vaccines
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83. Yang R, Cheung MC, Zhuge Y, Armstrong C, Koniaris LG, Sola JE: Primary solid tumors of the colon and rectum in the pediatric patient: a review of 270 cases. J Surg Res; 2010 Jun 15;161(2):209-16
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary solid tumors of the colon and rectum in the pediatric patient: a review of 270 cases.
  • OBJECTIVE: To study the outcomes of solid tumors of the colon and rectum in pediatric patients.
  • RESULTS: Overall, 270 patients with malignant tumors of the lower gastrointestinal tract were identified.
  • The annual incidence was 1.04 cases per million in 2005.
  • The majority of tumors arose in adolescents (68.1% were older than 15 y).
  • Tumors were more commonly seen in white (77.8%) and non-Hispanic (78.9%) patients.
  • Tumors were identified in the right colon (45.9%), transverse colon (9.3%), left colon (20.4%), rectum (15.2%), and anal canal (1.1%).
  • The most common histology of these tumors was adenocarcinoma (35.6%), followed by carcinoid (34.1%).
  • Disease specific 5- and 10-y-survival for the entire cohort was 61.0% and 57.9%, respectively.
  • Multivariate analysis of the cohort identified tumor stage (HR 8.39, P < 0.001 for distant disease), tumor type (signet ring HR 2.12, P = 0.025, and carcinoid HR = 0.14, P = 0.001), and surgical resection (no surgery HR 2.98, P = 0.010) as independent predictors of worse outcome.
  • CONCLUSION: In the pediatric population, solid tumors of the colon and rectum occur more frequently in the right side of the colon in teenagers.
  • Surgical resection significantly improves survival for most pediatric tumors of the lower gastrointestinal tract.
  • [MeSH-major] Colonic Neoplasms / epidemiology. Colonic Neoplasms / surgery. Colorectal Neoplasms / epidemiology. Rectal Neoplasms / epidemiology. Rectal Neoplasms / surgery
  • [MeSH-minor] Adolescent. Aging. Anus Neoplasms / epidemiology. Anus Neoplasms / mortality. Anus Neoplasms / pathology. Child. Child, Preschool. Colectomy. Continental Population Groups / statistics & numerical data. Ethnic Groups / statistics & numerical data. Female. Humans. Incidence. Male. Neoplasm Staging. United States / epidemiology

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 19285688.001).
  • [ISSN] 1095-8673
  • [Journal-full-title] The Journal of surgical research
  • [ISO-abbreviation] J. Surg. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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84. Brewster DH, Bhatti LA: Increasing incidence of squamous cell carcinoma of the anus in Scotland, 1975-2002. Br J Cancer; 2006 Jul 3;95(1):87-90
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  • [Title] Increasing incidence of squamous cell carcinoma of the anus in Scotland, 1975-2002.
  • In Scotland, since 1975-1979 (world) age-standardised incidence of squamous cell carcinoma of the anus has more than doubled, reaching 0.37 per 100,000 in males and 0.55 in females during 1998-2002, being somewhat higher in socioeconomically deprived areas.
  • [MeSH-major] Anus Neoplasms / epidemiology. Carcinoma, Squamous Cell / epidemiology

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  • (PMID = 16721368.001).
  • [ISSN] 0007-0920
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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85. Eckert L: Screening for anal dysplasia in women with cervical, vaginal, or vulvar dysplasia: yes, no, maybe? Obstet Gynecol; 2010 Sep;116(3):566-7
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  • [Title] Screening for anal dysplasia in women with cervical, vaginal, or vulvar dysplasia: yes, no, maybe?
  • [MeSH-major] Anus Neoplasms / diagnosis. Carcinoma in Situ / diagnosis. Genital Neoplasms, Female / complications

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  • [CommentOn] Obstet Gynecol. 2010 Sep;116(3):578-82 [20733438.001]
  • (PMID = 20733435.001).
  • [ISSN] 1873-233X
  • [Journal-full-title] Obstetrics and gynecology
  • [ISO-abbreviation] Obstet Gynecol
  • [Language] eng
  • [Publication-type] Comment; Editorial
  • [Publication-country] United States
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86. Choi WW, Tadros TS, Majmudar B: Anal fibroadenoma: report of a common tumor type in an unusual location. South Med J; 2007 Sep;100(9):914-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anal fibroadenoma: report of a common tumor type in an unusual location.
  • [MeSH-major] Anus Neoplasms / diagnosis. Fibroadenoma / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Epithelial Cells / pathology. Female. Hemorrhoids / diagnosis. Humans. Stromal Cells / pathology. Thrombosis / diagnosis

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  • (PMID = 17902297.001).
  • [ISSN] 0038-4348
  • [Journal-full-title] Southern medical journal
  • [ISO-abbreviation] South. Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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87. Schneider A, Lacreuse I, Moog R, Kauffmann I, Becmeur F: Buschke-Löwenstein anal tumour in children: two case reports. Eur J Pediatr Surg; 2009 Oct;19(5):330-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Buschke-Löwenstein anal tumour in children: two case reports.
  • [MeSH-major] Anus Neoplasms. Carcinoma, Squamous Cell. Condylomata Acuminata
  • [MeSH-minor] Child Abuse, Sexual / diagnosis. Child, Preschool. Electrocoagulation. Female. Humans. Male

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  • (PMID = 19199236.001).
  • [ISSN] 1439-359X
  • [Journal-full-title] European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift für Kinderchirurgie
  • [ISO-abbreviation] Eur J Pediatr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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88. Ramamoorthy S, Luo L, Luo E, Carethers JM: Tobacco smoking and risk of recurrence for squamous cell cancer of the anus. Cancer Detect Prev; 2008;32(2):116-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tobacco smoking and risk of recurrence for squamous cell cancer of the anus.
  • OBJECTIVE: Squamous cell cancer of the anus is associated with multiple risk factors, including infection with human papillomavirus, immunosuppression, chronic inflammation, and tobacco smoking, although there is little data on these factors for the prediction of recurrent disease.
  • Here, we evaluated the risk of recurrence and mortality of anal carcinoma in association with tobacco smoking.
  • METHODS: We conducted a retrospective review of cases of anal carcinoma from two local hospitals.
  • RESULTS: We identified 64 patients with squamous cell cancer of the anus, and 34 of these (53%) had a tobacco smoking history.
  • CONCLUSION: Tobacco smoking appears to be associated with anal carcinoma disease recurrence, and is related to increased mortality.
  • This data suggests that patients should be cautioned about tobacco smoking once a diagnosis of anal carcinoma is made in attempt to improve their long-term outcome.

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  • (PMID = 18639388.001).
  • [ISSN] 1525-1500
  • [Journal-full-title] Cancer detection and prevention
  • [ISO-abbreviation] Cancer Detect. Prev.
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / R01 DK067287; United States / NIDDK NIH HHS / DK / R24 DK080506; United States / NIDDK NIH HHS / DK / DK067287-01A2; United States / NIDDK NIH HHS / DK / R24 DK080506-01; United States / NIDDK NIH HHS / DK / R01 DK067287-01A2
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ NIHMS209533; NLM/ PMC3427794
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89. Val-Bernal JF, Mayorga M, Diego C, González-Vela MC: Pedunculated polypoid lymphangioma of the anal canal. Pathol Int; 2008 Jul;58(7):442-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pedunculated polypoid lymphangioma of the anal canal.
  • Lymphangioma is a rare benign lesion of the gastrointestinal tract, in which the large intestine is the least commonly involved site.
  • To the authors' knowledge a lymphangioma of the anal canal has not been reported.
  • Described herein is a case of pedunculated polypoid lymphangioma of the right lateral wall on the transitional zone of the anal canal measuring 1.7 x 1.3 x 1 cm in a 40-year-old woman.
  • A pedicle does not exclude the endoscopic diagnosis of lymphangioma.
  • Lymphangioma must be included in the differential diagnosis of polypoid lesions of the anal canal.
  • [MeSH-major] Anus Neoplasms / pathology. Lymphangioma / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Adult. Carcinoma, Squamous Cell / pathology. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Rectal Fistula / pathology

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  • (PMID = 18577114.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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90. Das P, Crane CH, Ajani JA: Current treatment for localized anal carcinoma. Curr Opin Oncol; 2007 Jul;19(4):396-400
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  • [Title] Current treatment for localized anal carcinoma.
  • PURPOSE OF REVIEW: Chemoradiation represents the standard of care for most patients with localized squamous cell carcinoma of the anal canal.
  • This article reviews randomized trials and recent studies on chemoradiation for anal cancer.
  • Recent studies have started to evaluate intensity modulated radiation therapy for anal cancer, in an effort to reduce acute and long-term toxicity from radiotherapy.
  • SUMMARY: The role of cisplatin in anal cancer is not completely clear, although an ongoing randomized trial (Anal Cancer Trial II) may help clarify the role of cisplatin.
  • Studies on tumor biology and patient genetics are warranted to identify patients that are most likely to benefit from newer locoregional and systemic therapies.
  • Intensity modulated radiation therapy appears to be a promising approach for reducing treatment-related toxicity in anal cancer patients.
  • The Radiation Therapy Oncology Group (RTOG) is conducting a phase II trial evaluating the multi-institutional feasibility of intensity modulated radiation therapy for anal cancer.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Anus Neoplasms / drug therapy. Carcinoma, Squamous Cell / drug therapy. Cisplatin / therapeutic use. Radiation-Sensitizing Agents / therapeutic use

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  • (PMID = 17545807.001).
  • [ISSN] 1040-8746
  • [Journal-full-title] Current opinion in oncology
  • [ISO-abbreviation] Curr Opin Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Radiation-Sensitizing Agents; 50SG953SK6 / Mitomycin; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
  • [Number-of-references] 21
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91. Tomimaru Y, Ohue M, Noura S, Tanida T, Miyashiro I, Yano M, Ohigashi H, Sasaki Y, Ishikawa O, Imaoka S: [A case of anal fistula cancer probably developing from intraluminal dissemination of rectal cancer]. Gan To Kagaku Ryoho; 2005 Oct;32(11):1776-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of anal fistula cancer probably developing from intraluminal dissemination of rectal cancer].
  • A 63-year-old man with a history of anal fistula was admitted to our hospital because the anal pain didn't disappear after the operation.
  • On digital examination, a hard mass measuring 3.0 cm in diameter was found at the anal canal.
  • Colonoscopy revealed another rectal cancer at 15 cm from anal verge.
  • Biopsy of the tumor also showed moderately differentiated adenocarcinoma, resembling the anal canal tumor.
  • Because the histological findings of both tumors were nearly identical, we considered that cancer cells from the rectal cancer had been implanted and developed the metastatic tumor in the anal fistula.
  • The patient underwent anterior resection for the rectal cancer, and a local resection for the anal canal cancer.
  • Immunohistochemical staining for Ki-67, p53, Muc2, CD10, CK-7, and CK-20 revealed similar patterns in both tumors.
  • Additionally, genetic analysis for p53, K-ras, and MSI revealed similar patterns in both tumors.
  • We may suggest from these results that cancer cells from the rectal cancer had been implanted and developed the metastatic tumor in the anal canal.
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma / secondary. Anus Neoplasms / secondary. Rectal Fistula / complications. Rectal Neoplasms / pathology
  • [MeSH-minor] Humans. Male. Middle Aged. Neoplasm Seeding


92. Abbasakoor F, Boulos PB: Anal intraepithelial neoplasia. Br J Surg; 2005 Mar;92(3):277-90
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  • [Title] Anal intraepithelial neoplasia.
  • BACKGROUND: Anal intraepithelial neoplasia (AIN) is believed to be a precursor of anal squamous cell cancer and its incidence is rising in high-risk groups, particularly those infected with the human immunodeficiency virus (HIV).
  • There is no standard management for AIN and this is mainly due to difficulties in both diagnosis and treatment.
  • [MeSH-major] Anal Canal / pathology. Anus Neoplasms. Carcinoma in Situ. Carcinoma, Squamous Cell
  • [MeSH-minor] Female. HIV Infections / complications. Humans. Immune Tolerance. Male. Papillomavirus Infections / complications. Precancerous Conditions / etiology. Precancerous Conditions / pathology. Precancerous Conditions / surgery. Risk Factors. Tumor Virus Infections / complications

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  • [Copyright] Copyright (c) 2005 British Journal of Surgery Society Ltd.
  • (PMID = 15736144.001).
  • [ISSN] 0007-1323
  • [Journal-full-title] The British journal of surgery
  • [ISO-abbreviation] Br J Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 131
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93. Alcindor T: Activity of paclitaxel in metastatic squamous anal carcinoma. Int J Colorectal Dis; 2008 Jul;23(7):717
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Activity of paclitaxel in metastatic squamous anal carcinoma.
  • [MeSH-major] Antineoplastic Agents, Phytogenic / therapeutic use. Anus Neoplasms / drug therapy. Carcinoma, Squamous Cell / drug therapy. Neoplasm Metastasis / drug therapy. Paclitaxel / therapeutic use

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  • (PMID = 18335224.001).
  • [ISSN] 0179-1958
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Letter; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; P88XT4IS4D / Paclitaxel
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94. Simon JM, Mazeron JJ, American Society for Therapeutic Radiology and Oncology (Astro): [48th meeting of the American Society for Therapeutic Radiology and Oncology (Astro)]. Bull Cancer; 2007 Feb;94(2):229-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] 48e réunion de l'American Society for Therapeutic Radiology and Oncology (Astro).
  • [MeSH-minor] Anus Neoplasms / drug therapy. Anus Neoplasms / radiotherapy. Breast Neoplasms / radiotherapy. Female. Humans. Male. Otorhinolaryngologic Neoplasms / drug therapy. Otorhinolaryngologic Neoplasms / radiotherapy. Philadelphia. Prostatic Neoplasms / radiotherapy. Radiation Oncology. United States

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  • (PMID = 17337392.001).
  • [ISSN] 1769-6917
  • [Journal-full-title] Bulletin du cancer
  • [ISO-abbreviation] Bull Cancer
  • [Language] fre
  • [Publication-type] Congresses
  • [Publication-country] France
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95. Wilkes G, Hartshorn K: Colon, rectal, and anal cancers. Semin Oncol Nurs; 2009 Feb;25(1):32-47
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Colon, rectal, and anal cancers.
  • OBJECTIVES: To review the incidence, risk factors, staging, diagnosis, and treatment of colon, rectal, and anal cancers, as well as nursing care associated with managing patients diagnosed with these malignancies.
  • CONCLUSIONS: Significant advances in the management of colon, rectal, and anal cancers in the past decade have extended patient survival.
  • Further clinical research will refine current therapeutic strategies and treatment decision-making aids while minimizing symptoms of disease and treatment.
  • IMPLICATIONS FOR NURSING PRACTICE: Nurses need to be familiar with risk factors, disease course, and current and emerging therapies to assist patients with treatment decision-making, and to anticipate and intervene in managing disease and treatment-induced problems.
  • [MeSH-major] Anus Neoplasms. Carcinoma, Squamous Cell. Colonic Neoplasms. Rectal Neoplasms
  • [MeSH-minor] Humans. Neoplasm Staging. Risk Factors

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  • (PMID = 19217504.001).
  • [ISSN] 0749-2081
  • [Journal-full-title] Seminars in oncology nursing
  • [ISO-abbreviation] Semin Oncol Nurs
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 92
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96. Duport C, Tiffet O, Perrot JL, Prévot N, Rey Y, Cambazard F: [Sentinel node mapping in anorectal melanoma]. Ann Chir; 2006 Nov;131(9):550-2
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  • Fifty months after initial treatment, the patient is still alive disease free.
  • Moreover, knowing the exact histological status of the regional nodes means that the relative merits of abdominoperineal resection and wild local excision could be compared in relation to tumor thickness.
  • [MeSH-major] Anus Neoplasms / pathology. Melanoma / pathology. Sentinel Lymph Node Biopsy

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  • (PMID = 16690018.001).
  • [ISSN] 0003-3944
  • [Journal-full-title] Annales de chirurgie
  • [ISO-abbreviation] Ann Chir
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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97. Pirog EC, Quint KD, Yantiss RK: P16/CDKN2A and Ki-67 enhance the detection of anal intraepithelial neoplasia and condyloma and correlate with human papillomavirus detection by polymerase chain reaction. Am J Surg Pathol; 2010 Oct;34(10):1449-55
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  • [Title] P16/CDKN2A and Ki-67 enhance the detection of anal intraepithelial neoplasia and condyloma and correlate with human papillomavirus detection by polymerase chain reaction.
  • The classification of anal intraepithelial neoplasia (AIN) in mucosal biopsies is subject to considerable interobserver variability.
  • The aim of this study was to determine whether Ki-67 and p16/CDKN2A immunolabeling enhanced diagnostic accuracy in the assessment of anal mucosal biopsies from patients with suspected human papillomavirus (HPV) infection.
  • The study consisted of 75 cases that were originally interpreted to represent normal anal transitional zone (n=15), fibroepithelial polyp (n=10), condyloma accuminatum (n=10), low-grade AIN (AIN1, n=20), and high-grade AIN (n=20), including 10 cases each of AIN2 and AIN3.
  • Thus, the final study group consisted of 17 samples of normal anal transition zone, 14 fibroepithelial polyps, 6 condylomata accuminata, and 38 cases of AIN (11 AIN1, 16 AIN2, and 11 AIN3).
  • None of the anal transition zone samples or fibroepithelial polyps showed Ki-67 or p16/CDKN2A staining.
  • We conclude that Ki-67 labeling detects anal HPV-related changes with a high degree of sensitivity and specificity, whereas increased p16/CDKN2A staining is strongly associated with high-grade squamous neoplasia.
  • These results indicate that a combination of these markers may aid interpretation of anal mucosal biopsy samples.
  • [MeSH-major] Anus Neoplasms / diagnosis. Carcinoma in Situ / diagnosis. Condylomata Acuminata / diagnosis. Cyclin-Dependent Kinase Inhibitor p16 / metabolism. Ki-67 Antigen / metabolism. Papillomaviridae / isolation & purification. Papillomavirus Infections / diagnosis
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / metabolism. Biopsy. Colonic Polyps / metabolism. Colonic Polyps / pathology. Colonic Polyps / virology. DNA Probes, HPV. Female. Humans. Immunohistochemistry. Male. Middle Aged. Precancerous Conditions / diagnosis. Precancerous Conditions / metabolism. Precancerous Conditions / virology. Predictive Value of Tests. Young Adult

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  • (PMID = 20871219.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / DNA Probes, HPV; 0 / Ki-67 Antigen
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98. Joseph KJ, Syme A, Small C, Warkentin H, Quon H, Ghosh S, Field C, Pervez N, Tankel K, Patel S, Usmani N, Severin D, Nijjar T, Fallone G, Pedersen J: A treatment planning study comparing helical tomotherapy with intensity-modulated radiotherapy for the treatment of anal cancer. Radiother Oncol; 2010 Jan;94(1):60-6
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  • [Title] A treatment planning study comparing helical tomotherapy with intensity-modulated radiotherapy for the treatment of anal cancer.
  • PURPOSE: A planning study to compare helical tomotherapy (HT) and intensity-modulated radiotherapy (IMRT) for the treatment of anal canal cancer.
  • MATERIALS AND METHODS: Sixteen (8 males and 8 females) patients with anal cancer previously treated radically were identified.
  • The planning goals were to deliver 54Gy to the tumor (PTV(54Gy)) and 48Gy to the nodes at risk (PTV(Node)) in 30 fractions.
  • [MeSH-major] Anus Neoplasms / radiotherapy. Radiotherapy, Intensity-Modulated. Tomography, Spiral Computed

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  • [Copyright] Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 19896229.001).
  • [ISSN] 1879-0887
  • [Journal-full-title] Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
  • [ISO-abbreviation] Radiother Oncol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
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99. Pantanowitz L, Dezube BJ: The anal Pap test as a screening tool. AIDS; 2010 Jan 28;24(3):463-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The anal Pap test as a screening tool.
  • [MeSH-major] Anus Neoplasms / pathology. Carcinoma, Squamous Cell / pathology. HIV Infections / pathology. Papillomaviridae / isolation & purification. Precancerous Conditions / pathology

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  • [CommentOn] AIDS. 2010 Jan 28;24(3):373-9 [20057313.001]
  • (PMID = 19926960.001).
  • [ISSN] 1473-5571
  • [Journal-full-title] AIDS (London, England)
  • [ISO-abbreviation] AIDS
  • [Language] eng
  • [Publication-type] Comment; Editorial
  • [Publication-country] England
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100. Fox P: Anal cancer screening in men who have sex with men. Curr Opin HIV AIDS; 2009 Jan;4(1):64-7
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  • [Title] Anal cancer screening in men who have sex with men.
  • PURPOSE OF REVIEW: To determine whether current evidence and expert opinion support the routine use of anal cytology and high-resolution anoscopy in men who have sex with men.
  • RECENT FINDINGS: Most recently published guidelines do not recommend routine anal cytology, but anal cancer is undoubtedly a serious and growing problem for HIV-positive patients.
  • The sensitivity and specificity of anal cytology is poor and adjuncts to cytology such as p16(ink4a) staining and human papillomavirus viral loads might be utilized to further reduce the number of patients requiring high-resolution anoscopy.
  • Despite the burden of high-grade squamous intraepithelial lesion in HIV negative men who have sex with men, anal cancer remains uncommon in this group.
  • SUMMARY: Although routine anal cytology is not advisable for men who have sex with men at present, be they HIV positive or negative, clinicians should be regularly performing digital rectal examination in those at high risk of anal cancer, both to facilitate early detection of anal cancer and in the interests of health promotion.
  • [MeSH-major] Anus Neoplasms / diagnosis. Carcinoma in Situ / diagnosis. Homosexuality, Male. Mass Screening
  • [MeSH-minor] Anal Canal / pathology. Antiretroviral Therapy, Highly Active. Biomarkers, Tumor / analysis. Clinical Trials as Topic. Early Detection of Cancer. Epidemiologic Studies. HIV Infections / complications. HIV Infections / drug therapy. Humans. Male. Papillomavirus Infections / diagnosis. Papillomavirus Infections / etiology. Papillomavirus Infections / pathology. Proctoscopy. Sensitivity and Specificity. Viral Load

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  • (PMID = 19343830.001).
  • [ISSN] 1746-6318
  • [Journal-full-title] Current opinion in HIV and AIDS
  • [ISO-abbreviation] Curr Opin HIV AIDS
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 25
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