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1. Kwong RA, Kalish LH, Nguyen TV, Kench JG, Bova RJ, Cole IE, Musgrove EA, Sutherland RL: p14ARF protein expression is a predictor of both relapse and survival in squamous cell carcinoma of the anterior tongue. Clin Cancer Res; 2005 Jun 1;11(11):4107-16
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] p14ARF protein expression is a predictor of both relapse and survival in squamous cell carcinoma of the anterior tongue.
  • PURPOSE: The INK4A-ARF locus at chromosome 9p21 is frequently altered in head and neck squamous cell carcinoma (SCC) and encodes two distinct tumor suppressors, p16(INK4A) and p14(ARF).
  • EXPERIMENTAL DESIGN: p14(ARF) protein expression was assessed by immunohistochemistry in a cohort of 140 patients with SCC of the anterior tongue.
  • CONCLUSIONS: These data show that in patients with SCC of the tongue, combined nuclear and nucleolar expression of p14(ARF) protein predicts for improved DFS and OS independent of established prognostic markers.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Tongue Neoplasms / pathology. Tumor Suppressor Protein p14ARF / biosynthesis
  • [MeSH-minor] Cell Cycle Proteins / analysis. Cohort Studies. Cyclin D1 / analysis. Cyclin-Dependent Kinase Inhibitor p16 / biosynthesis. Cyclin-Dependent Kinase Inhibitor p21. DNA-Binding Proteins / analysis. E2F Transcription Factors. E2F1 Transcription Factor. Humans. Immunohistochemistry. Ki-67 Antigen / analysis. Multivariate Analysis. Neoplasm Recurrence, Local. Neoplasm Staging. Predictive Value of Tests. Prognosis. Proportional Hazards Models. Retinoblastoma Protein / analysis. Survival Analysis. Transcription Factors / analysis. Tumor Suppressor Protein p53 / analysis

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  • (PMID = 15930346.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CDKN1A protein, human; 0 / Cell Cycle Proteins; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Cyclin-Dependent Kinase Inhibitor p21; 0 / DNA-Binding Proteins; 0 / E2F Transcription Factors; 0 / E2F1 Transcription Factor; 0 / E2F1 protein, human; 0 / Ki-67 Antigen; 0 / Retinoblastoma Protein; 0 / Transcription Factors; 0 / Tumor Suppressor Protein p14ARF; 0 / Tumor Suppressor Protein p53; 136601-57-5 / Cyclin D1
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2. Smeets R, Grosjean MB, Heiland M, Riediger D, Maciejewski O: Distant metastases of a squamous cell carcinoma of the tongue in peripheral skeletal muscles and adjacent soft tissues. Head Face Med; 2008;4:7
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  • [Title] Distant metastases of a squamous cell carcinoma of the tongue in peripheral skeletal muscles and adjacent soft tissues.
  • A 66-year-old female patient was admitted to our department with a large tumor of the tongue measuring 10 cm in diameter.
  • Histological analysis revealed a low grade squamous cell carcinoma (SCC) of the tongue.
  • Foci of distant metastases were found in the left upper anterior thoracal wall, near the intraabdominal portion of the aorta, near the right iliac crest and in both the right vastus medialis- and adductor magnus muscles.
  • The final diagnosis was a T4N3M1(G3)(C3) SCC of the tongue with multiple distant thoracal, abdominal and intramuscular metastases.
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. Muscle Neoplasms / secondary. Tongue Neoplasms / pathology

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  • (PMID = 18366774.001).
  • [ISSN] 1746-160X
  • [Journal-full-title] Head & face medicine
  • [ISO-abbreviation] Head Face Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2358884
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3. Lago-Méndez L, Blanco-Carrión A, Diniz-Freitas M, Gándara-Vila P, García-García A, Gándara-Rey JM: Rhomboid glossitis in atypical location: case report and differential diagnosis. Med Oral Patol Oral Cir Bucal; 2005 Mar-Apr;10(2):123-7
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  • Median rhomboid glossitis (MRG) is an uncommon benign abnormality of the tongue, most frequently affecting men.
  • It is typically located around the midline of the dorsum of the tongue, anterior to the lingual "V", appearing as a reddish, rhomboid area, depapillated, flat maculate or mamillated and raised by 2 - 5 mm.
  • This paper reports a case of rhomboid glossitis in a 61-year-old man who consulted for a painless raised lesion on the dorsum of the tongue, in left paramedial (not medial) location.
  • Other diagnoses considered but ruled out on the basis of the clinical and histopathological findings were haemangioma, pyogenic granuloma, amyloidosis, granular cell tumour, and squamous cell carcinoma.
  • [MeSH-major] Glossitis / pathology. Tongue / pathology
  • [MeSH-minor] Amyloidosis / diagnosis. Antifungal Agents / therapeutic use. Candida albicans / isolation & purification. Candidiasis, Oral / diagnosis. Diagnosis, Differential. Granular Cell Tumor / diagnosis. Granuloma, Pyogenic / diagnosis. Hemangioma / diagnosis. Humans. Male. Middle Aged. Tongue Neoplasms / diagnosis

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  • (PMID = 15735544.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng; spa
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Antifungal Agents
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4. Mackle T, O'Dwyer T: A comparative analysis of anterior versus posterior squamous cell carcinoma of the tongue: a 10-year review. J Laryngol Otol; 2006 May;120(5):393-6
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  • [Title] A comparative analysis of anterior versus posterior squamous cell carcinoma of the tongue: a 10-year review.
  • INTRODUCTION: The study sought to compare and contrast squamous cell carcinoma (SCC) of the anterior mobile tongue with SCC of the tongue base, with emphasis on clinical presentation, management and outcome.
  • METHODS: This was a retrospective, comparative analysis of patients treated for SCC of the tongue over a 10-year period.
  • RESULTS: The study included 142 patients, of whom 86 were treated for SCC of the anterior tongue and 56 for tongue base lesions.
  • Patients with carcinoma of the anterior tongue tended to present with a visible lump or ulceration of the tongue, whereas the majority of patients with tongue base SCC presented with pain.
  • Sixty per cent of anterior tongue lesions were early stage (I or II) at initial presentation as compared with 21 per cent of tongue base lesions.
  • CONCLUSION: Patients with anterior tongue lesions had a better prognosis, but this was not statistically significant when adjusted for stage.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Tongue Neoplasms / pathology

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  • (PMID = 16563198.001).
  • [ISSN] 0022-2151
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
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5. Taghi A, Motamedi MH: Riga-Fede disease: a histological study and case report. Indian J Dent Res; 2009 Apr-Jun;20(2):227-9
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  • This lesion may occur under the tongue in infants as a result of chronic mucosal trauma caused by mandibular anterior primary teeth during nursing and is termed Riga-Fede disease (RFD).
  • The clinical presentation many resemble squamous cell carcinoma causing concern.
  • [MeSH-major] Oral Ulcer / pathology. Tongue Diseases / pathology
  • [MeSH-minor] Chronic Disease. Diagnosis, Differential. Granuloma / pathology. Humans. Infant. Male. Tongue / injuries. Tooth Eruption

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  • (PMID = 19553727.001).
  • [ISSN] 1998-3603
  • [Journal-full-title] Indian journal of dental research : official publication of Indian Society for Dental Research
  • [ISO-abbreviation] Indian J Dent Res
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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6. Veness MJ, Morgan GJ, Sathiyaseelan Y, Gebski V: Anterior tongue cancer and the incidence of cervical lymph node metastases with increasing tumour thickness: should elective treatment to the neck be standard practice in all patients? ANZ J Surg; 2005 Mar;75(3):101-5
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  • [Title] Anterior tongue cancer and the incidence of cervical lymph node metastases with increasing tumour thickness: should elective treatment to the neck be standard practice in all patients?
  • BACKGROUND: There is an increasing risk of cervical lymph node metastases as tumour thickness increases in patients with anterior tongue squamous cell carcinoma (SCC).
  • The role of elective neck treatment in early anterior tongue cancer in unclear.
  • METHODS: Patients diagnosed with anterior tongue cancer and treated with glossectomy +/- neck dissection were identified.
  • RESULTS: Between 1980 and 2002 99 patients (63 male and 36 female) with anterior tongue SCC were treated at Westmead Hospital, Sydney, and had a documented tumour thickness.
  • CONCLUSIONS: Elective treatment to the ipsilateral neck is not indicated in all patients with anterior tongue cancer.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Glossectomy. Lymphatic Diseases / pathology. Neck Dissection. Tongue Neoplasms / pathology


7. Schwartz DL, Hutcheson K, Barringer D, Tucker SL, Kies M, Holsinger FC, Ang KK, Morrison WH, Rosenthal DI, Garden AS, Dong L, Lewin JS: Candidate dosimetric predictors of long-term swallowing dysfunction after oropharyngeal intensity-modulated radiotherapy. Int J Radiat Oncol Biol Phys; 2010 Dec 1;78(5):1356-65
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  • METHODS AND MATERIALS: Thirty-one patients with Stage IV oropharyngeal squamous carcinoma enrolled on a Phase II trial were prospectively evaluated by modified barium swallow studies at baseline, and 6, 12, and 24 months post-IMRT treatment.
  • Twenty-one (68%) cases were base of tongue and 10 (32%) were tonsil.
  • RESULTS: Dose-volume constraints (V30 < 65% and V35 < 35% for anterior oral cavity and V55 < 80% and V65 < 30% for high superior pharyngeal constrictors) predictive for objective swallowing dysfunction were identified by univariate and multivariate analyses.

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
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  • (PMID = 20646872.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P30 CA016672; United States / NCI NIH HHS / CA / R21 CA132281; United States / NCI NIH HHS / CA / CA132281
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS575664; NLM/ PMC4034521
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8. Raguse JD, Bezeluk A, Bier J, Klein M: [The central island tongue flap for the reconstruction of the anterior floor of the mouth]. Mund Kiefer Gesichtschir; 2007 Jan;11(1):53-7
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  • [Title] [The central island tongue flap for the reconstruction of the anterior floor of the mouth].
  • BACKGROUND: There are several techniques described for the reconstruction of the anterior floor of mouth after tumour surgery.
  • Here, we point out the advantages of the central island tongue flap for this indication.
  • PATIENTS AND METHODS: We report on 20 patients with medium sized defect in the anterior floor of mouth, which was reconstructed with the central island tongue flap.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Mouth Floor / surgery. Mouth Neoplasms / surgery. Surgical Flaps

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  • (PMID = 17216515.001).
  • [ISSN] 1432-9417
  • [Journal-full-title] Mund-, Kiefer- und Gesichtschirurgie : MKG
  • [ISO-abbreviation] Mund Kiefer Gesichtschir
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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9. Ko AB, Lavertu P, Rezaee RP: Double bilobed radial forearm free flap for anterior tongue and floor-of-mouth reconstruction. Ear Nose Throat J; 2010 Apr;89(4):177-9
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  • [Title] Double bilobed radial forearm free flap for anterior tongue and floor-of-mouth reconstruction.
  • We describe what is, to the best of our knowledge, the first use of a double bilobed radial forearm free flap in reconstructive surgery of the tongue and floor of the mouth following bilateral tumor resection.
  • Our patient was a 78-year-old man who had experienced tumor recurrence in the anterior floor of the mouth after previous resection and radiotherapy.
  • Eleven weeks postoperatively, the patient could extend his tongue to his hard palate and past his mandibular alveolus anteriorly.
  • Although the use of a single bilobed radial forearm flap is widely used after hemiglossectomy, our double bilobed modification extends this technique to anterior tongue and floor-of-mouth defects.
  • This technique provides adequate bulk while allowing for depth of a ventral sulcus that will minimize tethering of the tongue and reduce oral incompetence.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Mouth Floor / surgery. Neoplasm Recurrence, Local / surgery. Reconstructive Surgical Procedures / methods. Surgical Flaps. Tongue Neoplasms / surgery

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  • (PMID = 20397146.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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10. Massarelli O, Gobbi R, Raho MT, Tullio A: Three-dimensional primary reconstruction of anterior mouth floor and ventral tongue using the 'trilobed' buccinator myomucosal island flap. Int J Oral Maxillofac Surg; 2008 Oct;37(10):917-22
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  • [Title] Three-dimensional primary reconstruction of anterior mouth floor and ventral tongue using the 'trilobed' buccinator myomucosal island flap.
  • Three-dimensional reconstruction of the anterior mouth floor and ventral tongue after ablative surgery can be achieved using several techniques.
  • The flap provided the correct anatomical oral reconstruction for the anterior mouth floor and ventral tongue.
  • The function of the tongue, oral intake and mastication were not impaired.
  • The trilobed buccinator myomucosal island flap is a suitable option for the three-dimensional reconstruction of the anterior mouth floor and ventral tongue.
  • [MeSH-major] Mouth Floor / surgery. Mouth Mucosa / transplantation. Reconstructive Surgical Procedures / methods. Surgical Flaps. Tongue / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Arteries / surgery. Carcinoma, Squamous Cell / surgery. Cheek / blood supply. Eating / physiology. Facial Muscles / blood supply. Female. Humans. Male. Mastication / physiology. Maxillary Artery / surgery. Middle Aged. Mouth Neoplasms / surgery. Neck Dissection

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  • (PMID = 18835756.001).
  • [ISSN] 0901-5027
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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11. Chien CY, Su CY, Hwang CF, Chuang HC, Jeng SF, Chen YC: Ablation of advanced tongue or base of tongue cancer and reconstruction with free flap: functional outcomes. Eur J Surg Oncol; 2006 Apr;32(3):353-7
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  • [Title] Ablation of advanced tongue or base of tongue cancer and reconstruction with free flap: functional outcomes.
  • AIM: To evaluate the functional outcomes of patients who underwent total or nearly total glossectomy for advanced tongue or base of tongue cancer.
  • MATERIAL AND METHODS: We used the radial forearm free flap (RFFF), anterior lateral thigh flap (ALTF) or fibular osteocutaneous flap (FOCF) to reconstruct the oral defect after radical resection in 39 patients undergoing total or nearly total glossectomy with laryngeal preservation.
  • The cumulative 4-year survival rates were 63.8% for tongue cancer and 42.9% for base of tongue cancer.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Catheter Ablation. Glossectomy / methods. Surgical Flaps. Tongue Neoplasms / surgery

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  • (PMID = 16455224.001).
  • [ISSN] 0748-7983
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
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12. Brown JS, Rogers SN, Lowe D: A comparison of tongue and soft palate squamous cell carcinoma treated by primary surgery in terms of survival and quality of life outcomes. Int J Oral Maxillofac Surg; 2006 Mar;35(3):208-14
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  • [Title] A comparison of tongue and soft palate squamous cell carcinoma treated by primary surgery in terms of survival and quality of life outcomes.
  • In the surgical management of oral cancer the resection and reconstruction of the mobile tongue and soft palate are most important if function is to be maintained.
  • This study compares the functional and health-related quality of life outcomes for primary surgery and reconstruction of the anterior tongue and soft palate.
  • From a cohort of 566 patients treated from 1992 to 2002, 118 fitted the criteria for anterior tongue and 44 for soft palate resection.
  • In terms of speech and swallowing a 3/4 or total anterior glossectomy had a worse outcome than a 1/4 or 1/2.
  • The functional results of 3/4 and total soft palate reconstruction were superior to 3/4 and total anterior tongue resections and were similar to the whole cohort.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Palatal Neoplasms / surgery. Palate, Soft / surgery. Quality of Life. Tongue Neoplasms / surgery
  • [MeSH-minor] Cohort Studies. Deglutition / physiology. Female. Follow-Up Studies. Glossectomy / classification. Glossectomy / rehabilitation. Humans. Male. Mandible / surgery. Middle Aged. Neck Dissection. Neoplasm Recurrence, Local / pathology. Prospective Studies. Reconstructive Surgical Procedures. Speech / physiology. Surgical Flaps. Survival Rate. Tongue / physiopathology. Treatment Outcome

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  • (PMID = 16343850.001).
  • [ISSN] 0901-5027
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Denmark
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13. Garavello W, Spreafico R, Somigliana E, Gaini L, Pignataro L, Gaini RM: Prognostic influence of gender in patients with oral tongue cancer. Otolaryngol Head Neck Surg; 2008 Jun;138(6):768-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prognostic influence of gender in patients with oral tongue cancer.
  • OBJECTIVES: The purpose of this study was to evaluate the independent role of gender in affecting prognosis in patients with anterior tongue cancer.
  • Female patients with squamous cell carcinoma of the tongue were identified and matched to men for year of diagnosis, age, TNM classification, histologic grading, and treatment modalities.
  • CONCLUSION: In this study, gender does not influence prognosis in patients with oral tongue cancer.
  • [MeSH-major] Sex Factors. Tongue Neoplasms / pathology. Tongue Neoplasms / therapy

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  • (PMID = 18503852.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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14. Jamshed A, Hussain R, Rehman K, Iqbal H, Hameed S, Majeed U, Shah MA, Azhar R, Ahmed Q, Faruqui Z: Primary squamous cell carcinoma of the oral cavity at presentation in Pakistan. J Clin Oncol; 2009 May 20;27(15_suppl):e17002

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary squamous cell carcinoma of the oral cavity at presentation in Pakistan.
  • : e17002 Background: Squamous cell carcinoma of oral cavity (SCCOC) is characterized by marked geographical differences in frequency and site distribution.
  • Subsite within oral cavity; anterior tongue 41.1% (274), buccal mucosa 26.6% (177), lower gingival and alveolus 19.5% (130), upper gingival and alveolus 4.1% (27), lips 3.6% (24), retromolar trigone 2.9% (19), hard palate 1.7% (11), and floor mouth 0.6 (4).
  • CONCLUSIONS: Approximately 80% of patients with primary SCCOC present with stage III or IV disease with anterior tongue as the most common subsite in our hospital.

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  • (PMID = 27961650.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. Vered M, Allon I, Buchner A, Dayan D: Stromal myofibroblasts and malignant transformation in a 4NQO rat tongue carcinogenesis model. Oral Oncol; 2007 Nov;43(10):999-1006
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  • [Title] Stromal myofibroblasts and malignant transformation in a 4NQO rat tongue carcinogenesis model.
  • This study assesses the correlation of changes in the density of stromal myofibroblasts to propagation of histopathologic alterations and proliferative activity of the epithelium in a rat 4NQO-induced tongue rat carcinogenesis model.Forty-three male Wistar rats were administered 0.001% 4NQO in drinking water for: 0 (n=7, control), 7 (n=4), 8 (n=8), 14 (n=6), 22 (n=9), and 28 (n=9) weeks, after which they were euthanized.
  • Tongue sections were divided equally into anterior, middle and posterior thirds.
  • Each third was given a histopathologic score (hematoxylin and eosin), ranging from normal, hyperplasia/hyperkeratosis, and escalating degrees of dysplasia to carcinoma, and analyzed by the point-counting method for density of epithelium-associated stromal myofibroblasts (alphaSMA) and of proliferating epithelial cells (PCNA).
  • Histopathologic changes significantly increased in severity (carcinoma) with duration of 4NQO administration (p<0.001) in the posterior third of the tongue.
  • The density of stromal myofibroblasts and proliferating epithelial cells was significantly higher in the posterior third of the tongue at 28 weeks compared to the other time points and locations (p<0.001, p=0.01, respectively).
  • Significant correlations were found between occurrence of carcinoma and the increase in density of stromal myofibroblasts (p<0.001) and of proliferating epithelial cells (p=0.001) in the posterior third of the tongue.
  • Increased density of stromal myofibroblasts was distinctively associated with the development of carcinoma but not with pre-malignant changes.
  • Defining the mechanism of evolvement of carcinoma-associated stromal myofibroblasts is expected to further broaden our knowledge on the micro-environmental events occurring during the malignant transformation.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Cell Transformation, Neoplastic / pathology. Tongue Neoplasms / pathology
  • [MeSH-minor] 4-Nitroquinoline-1-oxide. Animals. Carcinogens. Fibroblasts / pathology. Male. Proliferating Cell Nuclear Antigen / analysis. Rats. Rats, Wistar. Stromal Cells / pathology

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  • (PMID = 17257886.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Carcinogens; 0 / Proliferating Cell Nuclear Antigen; 56-57-5 / 4-Nitroquinoline-1-oxide
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16. Bianchi B, Ferri A, Ferrari S, Copelli C, Boni P, Sesenna E: Reconstruction of anterior through and through oromandibular defects following oncological resections. Microsurgery; 2010;30(2):97-104
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Reconstruction of anterior through and through oromandibular defects following oncological resections.
  • BACKGROUND: Resections of oromandibular squamous cell carcinoma involving anterior mandible, floor of the mouth, and the skin, lead to composite oromandibular defects that can be approached in several ways depending on the extension of the bone defect, of the soft tissue and cutaneous resection, the patient's general status, and the prognosis.
  • CONCLUSION: Reconstruction of the anterior mandible is strongly indicated whenever possible.
  • When the defect involves the tongue, the best results are provided by the association of two free flaps.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Mandibular Neoplasms / surgery. Microsurgery. Mouth Neoplasms / surgery. Reconstructive Surgical Procedures. Surgical Flaps

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  • [Copyright] Copyright 2009 Wiley-Liss, Inc. Microsurgery, 2010.
  • (PMID = 19957314.001).
  • [ISSN] 1098-2752
  • [Journal-full-title] Microsurgery
  • [ISO-abbreviation] Microsurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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17. Wang H, Fraser K, Bortolotti C, Lanzino G: Emergent endovascular treatment with direct carotid puncture for exsanguinating Carotid Blowout Syndrome. Neurocrit Care; 2005;2(2):176-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: We report a 53-year-old male with squamous cell carcinoma of the anterior tongue presented with a sentinel hemoptysis followed by a massive oral hemorrhage.

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  • (PMID = 16159061.001).
  • [ISSN] 1541-6933
  • [Journal-full-title] Neurocritical care
  • [ISO-abbreviation] Neurocrit Care
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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18. Margaritescu C, Raica M, Pirici D, Simionescu C, Mogoanta L, Stinga AC, Stinga AS, Ribatti D: Podoplanin expression in tumor-free resection margins of oral squamous cell carcinomas: an immunohistochemical and fractal analysis study. Histol Histopathol; 2010 06;25(6):701-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Podoplanin expression in tumor-free resection margins of oral squamous cell carcinomas: an immunohistochemical and fractal analysis study.
  • The aim of this study was to establish podoplanin expression in the tumor-free resection margins of oral squamous cell carcinomas (OSCCs) and to evaluate the geometric complexity of the lymphatic vessels in oral mucosa by utilizing fractal analysis.
  • As concerns the study of the density and complexity of oral lymphatic vessels architecture by means of immunohistochemistry (D2-40, CD31 and Ki-67 antibodies) and fractal analysis, we demonstrated that in normal oral mucosa the geometry of the lymphatic vessels was less complex at the level of the lower lip compared to the anterior part of the oral floor mucosa or the tongue.
  • A comparative analysis between the normal and pathological aspects revealed statistically significant differences between the fractal dimension (FD) of the vessels' outline, especially in the tongue.
  • [MeSH-major] Carcinoma, Squamous Cell / metabolism. Membrane Glycoproteins / metabolism. Mouth Neoplasms / metabolism
  • [MeSH-minor] Aged. Antibodies, Monoclonal / chemistry. Antibodies, Monoclonal / metabolism. Antibodies, Monoclonal, Murine-Derived. Biomarkers, Tumor / metabolism. Cell Nucleus / metabolism. Cell Nucleus / pathology. Female. Fluorescent Antibody Technique, Indirect. Fractals. Humans. Hyperplasia / metabolism. Hyperplasia / pathology. Image Processing, Computer-Assisted. Lip / pathology. Lymphatic Vessels / metabolism. Lymphatic Vessels / pathology. Male. Middle Aged. Mouth Mucosa / metabolism. Mouth Mucosa / pathology. Tongue / pathology

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  • (PMID = 20376776.001).
  • [ISSN] 1699-5848
  • [Journal-full-title] Histology and histopathology
  • [ISO-abbreviation] Histol. Histopathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Biomarkers, Tumor; 0 / Membrane Glycoproteins; 0 / PDPN protein, human; 0 / monoclonal antibody D2-40
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19. Yamashita H, Nakagawa K, Nakamura N, Abe K, Asakage T, Ohmoto M, Okada S, Matsumoto I, Hosoi Y, Sasano N, Yamakawa S, Ohtomo K: Relation between acute and late irradiation impairment of four basic tastes and irradiated tongue volume in patients with head-and-neck cancer. Int J Radiat Oncol Biol Phys; 2006 Dec 1;66(5):1422-9
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  • [Title] Relation between acute and late irradiation impairment of four basic tastes and irradiated tongue volume in patients with head-and-neck cancer.
  • In Group A, the radiation fields included most of the tongue (n = 100), and in Group B the radiation fields did not include the tip of the tongue (n = 18).
  • CONCLUSIONS: Unless the anterior part of the tongue was irradiated, taste loss was not observed during RT.
  • When the anterior part of the tongue was irradiated, a difference by radiation dose was not observed in the taste loss pattern.
  • [MeSH-major] Head and Neck Neoplasms / radiotherapy. Taste / radiation effects. Taste Disorders / etiology. Tongue / radiation effects
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma, Squamous Cell / drug therapy. Carcinoma, Squamous Cell / radiotherapy. Female. Humans. Male. Middle Aged. Radiotherapy Dosage. Taste Threshold

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  • (PMID = 17084561.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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20. D'Cruz AK, Siddachari RC, Walvekar RR, Pantvaidya GH, Chaukar DA, Deshpande MS, Pai PS, Chaturvedi P: Elective neck dissection for the management of the N0 neck in early cancer of the oral tongue: need for a randomized controlled trial. Head Neck; 2009 May;31(5):618-24
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Elective neck dissection for the management of the N0 neck in early cancer of the oral tongue: need for a randomized controlled trial.
  • BACKGROUND: The aim of this study is to determine the need for a randomized controlled trial in order to define the role of an elective neck dissection (END) in the treatment of early tongue cancers.
  • METHODS: We present a large retrospective analysis of patients with T1-2 N0 squamous cell cancers of the oral anterior tongue treated at a single institution.
  • A total of 359 eligible patients with early tongue cancers were divided into 2 groups: END and wait and watch (WW).
  • [MeSH-major] Carcinoma, Squamous Cell / therapy. Elective Surgical Procedures. Neck Dissection. Tongue Neoplasms / therapy


21. O'Regan EM, Toner ME, Finn SP, Fan CY, Ring M, Hagmar B, Timon C, Smyth P, Cahill S, Flavin R, Sheils OM, O'Leary JJ: p16(INK4A) genetic and epigenetic profiles differ in relation to age and site in head and neck squamous cell carcinomas. Hum Pathol; 2008 Mar;39(3):452-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] p16(INK4A) genetic and epigenetic profiles differ in relation to age and site in head and neck squamous cell carcinomas.
  • Head and neck squamous cell carcinoma (HNSCC) typically affects male smokers older than 55 years.
  • All cases showing p16 methylation were from the anterior tongue, and 75% of them were young patients.
  • Interestingly, HPV 16 messenger RNA was detected exclusively in HNSCC from the base of tongue lesions and was only found in males.
  • This differs from the patient profile of HNSCC in the young, which affects the anterior tongue and commonly females, thus, making it highly unlikely that this virus is a primary causative agent of HNSCC in these young adults.
  • [MeSH-major] Carcinoma, Squamous Cell / genetics. Epigenesis, Genetic. Genes, p16. Head and Neck Neoplasms / genetics. Head and Neck Neoplasms / pathology

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  • (PMID = 18261630.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Viral; 0 / RNA, Messenger
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22. Maciejewski A, Szymczyk C, Wierzgoń J: Triple skin island fibula free flap: a good choice for combined mandible and tongue defect reconstruction. J Reconstr Microsurg; 2008 Oct;24(7):461-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Triple skin island fibula free flap: a good choice for combined mandible and tongue defect reconstruction.
  • Resections of malignant tumors involving the mandible and anterior tongue result in complex defects that are still real challenges for reconstructive surgeons.
  • This article documents the modification of the fibula free flap where triple skin islands are used for reconstruction of anterior tongue and floor of the mouth.
  • Eight such reconstructions have been performed on patients who underwent complex resection of the anterior mandible together with the mobile part of the tongue.
  • The presented modification of fibula free flap can be an alternative to double flaps in complex reconstruction of the mandible and mobile tongue.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Mandible / surgery. Mandibular Neoplasms / surgery. Reconstructive Surgical Procedures / methods. Surgical Flaps. Tongue / surgery. Tongue Neoplasms / surgery

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  • (PMID = 18688766.001).
  • [ISSN] 0743-684X
  • [Journal-full-title] Journal of reconstructive microsurgery
  • [ISO-abbreviation] J Reconstr Microsurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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23. Brennan PA, Webb R, Kemidi F, Spratt J, Standring S: Great auricular communication with the marginal mandibular nerve - a previously unreported anatomical variant. Br J Oral Maxillofac Surg; 2008 Sep;46(6):492-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • During an elective neck dissection for a squamous cell carcinoma of the tongue, we found that the anterior division of the great auricular nerve divided, with a long branch that passed into the submandibular triangle anterior and superficial to the facial vein, and was joined on its deep surface by the marginal mandibular division of the facial nerve.
  • [MeSH-minor] Carcinoma, Squamous Cell / surgery. Cervical Plexus / pathology. Facial Nerve / pathology. Female. Humans. Middle Aged. Neck Dissection. Parotid Gland / innervation. Tongue Neoplasms / surgery. Veins / pathology

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  • [CommentIn] Br J Oral Maxillofac Surg. 2009 Sep;47(6):494-5; author reply 495-6 [19481844.001]
  • (PMID = 18242803.001).
  • [ISSN] 1532-1940
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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24. Raju B, Haug SR, Ibrahim SO, Heyeraas KJ: High interstitial fluid pressure in rat tongue cancer is related to increased lymph vessel area, tumor size, invasiveness and decreased body weight. J Oral Pathol Med; 2008 Mar;37(3):137-44
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  • [Title] High interstitial fluid pressure in rat tongue cancer is related to increased lymph vessel area, tumor size, invasiveness and decreased body weight.
  • Measurements of IFP in normal tongue and in tongue cancer are lacking.
  • MATERIALS AND METHODS: In the present study, tongue squamous cell carcinoma (SCC) was induced by adding the carcinogen 4-nitroquinoline oxide in drinking water for 19 weeks.
  • RESULTS: In normal tongue, IFP averaged 3.1 +/- 0.3 mmHg.
  • The IFP, both in the tumor (29.1 +/- 2.9 mmHg) and 0.5 cm anterior to it (15.4 +/- 2.1 mmHg) was consistently increased (P < 0.005) with values ranging from 10 to 40 mmHg.
  • CONCLUSIONS: Our data show that IFP is increased in tongue cancer.
  • [MeSH-major] Carcinoma, Squamous Cell / physiopathology. Extracellular Fluid / physiology. Lymphatic Vessels / pathology. Tongue Neoplasms / physiopathology

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  • (PMID = 18251937.001).
  • [ISSN] 1600-0714
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / 4-nitroquinolone-1-oxide; 0 / Quinolones; 56-57-5 / 4-Nitroquinoline-1-oxide
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25. Rapidis AD, Trichas M, Stavrinidis E, Roupakia A, Ioannidou G, Kritselis G, Liossi P, Giannakouras G, Douzinas EE, Katsilieris I: Induction chemotherapy followed by concurrent chemoradiation in advanced squamous cell carcinoma of the head and neck: final results from a phase II study with docetaxel, cisplatin and 5-fluorouracil with a four-year follow-up. Oral Oncol; 2006 Aug;42(7):675-84
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  • [Title] Induction chemotherapy followed by concurrent chemoradiation in advanced squamous cell carcinoma of the head and neck: final results from a phase II study with docetaxel, cisplatin and 5-fluorouracil with a four-year follow-up.
  • Encouraging results have recently been reported in patients (pts) with locally advanced unresectable squamous cell carcinoma of the head and neck (SCCHN) when induction chemotherapy (IC) is used and followed by radiotherapy (RT).
  • The site of the primary tumors was the anterior mouth in 9 pts, base of tongue and oropharynx in 12, middle third of the face in 8 and larynx in 13.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Squamous Cell / drug therapy. Head and Neck Neoplasms / drug therapy

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  • (PMID = 16731029.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Taxoids; 15H5577CQD / docetaxel; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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26. Bekiroglu F, Wright S, Grew N: Chondroradionecrosis of larynx following radiotherapy for metastatic neck disease originating from oral carcinoma. Int J Oral Maxillofac Surg; 2007 May;36(5):459-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Chondroradionecrosis of larynx following radiotherapy for metastatic neck disease originating from oral carcinoma.
  • The patient underwent excision of necrotic anterior skin of the neck, together with devitalized thyroid cartilage and most of the cricoid cartilage, and reconstruction with pectoralis major muscle transposition.
  • [MeSH-major] Carcinoma, Squamous Cell / radiotherapy. Cricoid Cartilage / radiation effects. Laryngeal Diseases / etiology. Mouth Neoplasms / radiotherapy. Radiation Injuries / etiology. Thyroid Cartilage / radiation effects
  • [MeSH-minor] Adult. Follow-Up Studies. Humans. Male. Mouth Floor / radiation effects. Mouth Floor / surgery. Neck Dissection. Neoplasms, Second Primary / surgery. Pectoralis Muscles / transplantation. Radiotherapy, Adjuvant. Skin Transplantation. Tongue Neoplasms / radiotherapy. Tongue Neoplasms / surgery

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  • (PMID = 17145167.001).
  • [ISSN] 0901-5027
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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27. Kakarala K, Faquin WC, Deschler DG: A comparison of histopathologic margin assessment after steel scalpel, monopolar electrosurgery, and ultrasonic scalpel glossectomy in a rat model. Laryngoscope; 2010;120 Suppl 4:S155

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVES: Histopathologic margin assessment is important in guiding treatment and determining prognosis for squamous cell cancer of the oral tongue.
  • METHODS: The anterior tongue of thirty Sprague-Dawley rats was excised using either steel scalpel, monopolar electrosurgery, or ultrasonic scalpel (three groups of ten).
  • [MeSH-minor] Analysis of Variance. Animals. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / surgery. Disease Models, Animal. Hemostasis, Surgical. Male. Rats. Rats, Sprague-Dawley. Steel. Surgical Instruments. Tongue Neoplasms / pathology. Tongue Neoplasms / surgery

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  • (PMID = 21225753.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 12597-69-2 / Steel
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28. Hsiao HT, Leu YS, Liu CJ, Tung KY, Lin CC: Radial forearm versus anterolateral thigh flap reconstruction after hemiglossectomy: functional assessment of swallowing and speech. J Reconstr Microsurg; 2008 Feb;24(2):85-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The authors retrospectively compared the results of postoperative speech and swallowing in patients who had undergone hemiglossectomy for carcinoma of the anterior tongue.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Deglutition. Glossectomy. Speech. Surgical Flaps. Tongue Neoplasms / surgery

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  • (PMID = 18415928.001).
  • [ISSN] 0743-684X
  • [Journal-full-title] Journal of reconstructive microsurgery
  • [ISO-abbreviation] J Reconstr Microsurg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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29. de Visscher JG: [Treatment and prognosis of oral cancer]. Ned Tijdschr Tandheelkd; 2008 Apr;115(4):192-8
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  • Squamous cell carcinoma is the most common variety of malignant oral tumour.
  • Most commonly oral carcinomas occur at the lateral tongue surfaces and at the anterior part of the floor of the mouth.
  • When the diagnosis squamous cell carcinoma is established, the patient will be referred to a multidisciplinary head and neck oncological centre for additional diagnostics and treatment.
  • [MeSH-major] Carcinoma, Squamous Cell / therapy. Mouth Neoplasms / therapy. Oral Surgical Procedures / methods

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  • (PMID = 18512517.001).
  • [ISSN] 0028-2200
  • [Journal-full-title] Nederlands tijdschrift voor tandheelkunde
  • [ISO-abbreviation] Ned Tijdschr Tandheelkd
  • [Language] dut
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 11
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30. Iype EM, Sebastian P, Mathew A, Balagopal PG, Varghese BT, Thomas S: The role of selective neck dissection (I-III) in the treatment of node negative (N0) neck in oral cancer. Oral Oncol; 2008 Dec;44(12):1134-8
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  • It is now possible to limit the extent of selective neck dissection for mucosal squamous cell carcinoma of the head and neck by sparing selected lymphatic levels thereby reducing the morbidity.
  • A retrospective analysis of Squamous cell carcinoma of oral cavity with N0 neck from 1998 to 2004 was performed.
  • Seventy two percent of the patients had primary tumors in the anterior two-thirds of the tongue.
  • SND (I-III) is a sound and effective procedure in the management of clinically negative neck in squamous cell carcinoma of the oral cavity.
  • It probably has a therapeutic role in the selected cases of squamous cell carcinoma of the oral cavity with N1 neck, and in these cases an extension of dissection to levels IV and V is beneficial.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Mouth Neoplasms / surgery. Neck Dissection / methods

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  • (PMID = 18486527.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
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31. Maurizio SJ, Eckart AL: A case study associated with oropharyngeal cancer. J Dent Hyg; 2010;84(4):170-6
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  • PURPOSE: Squamous cell carcinoma (SCC) is the most common oral malignancy, commonly located on the anterior floor of the mouth, lateral borders of the tongue, tonsillar pillars and lateral soft palate.
  • Biopsy confirmed the diagnosis of SCC of the left tonsil.

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  • (PMID = 21047462.001).
  • [ISSN] 1553-0205
  • [Journal-full-title] Journal of dental hygiene : JDH
  • [ISO-abbreviation] J Dent Hyg
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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32. Gogălniceanu D, Vicol C, Costan VV, Trandafir D, Trandafir V, Lupu-Bratiloveanu P: [A review of 15 years of experience in using the musculo-mucosal lingual flap]. Rev Med Chir Soc Med Nat Iasi; 2007 Jan-Mar;111(1):232-7
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  • RESULTS: The main indication has been the reconstruction of the residual defects after resection of the mucosal mouth floor carcinomas (especially those located in the anterior third of the mouth or with gingival and alveolar invasion) or after resection of the gingival-alveolar mandible carcinomas with invasion of the mouth floor.
  • Mobility of the remaining of the tongue was acceptable and physiotherapy had a significant impact in recovering an intelligible phonation and for better mastication and deglutition due to compensatory hypertrophy of the lingual musculature.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Mouth Neoplasms / surgery. Reconstructive Surgical Procedures / methods. Surgical Flaps. Tongue / surgery

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  • (PMID = 17595873.001).
  • [ISSN] 0048-7848
  • [Journal-full-title] Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i
  • [ISO-abbreviation] Rev Med Chir Soc Med Nat Iasi
  • [Language] rum
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Romania
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33. Just T, Stave J, Bombor I, Kreutzer HJ, Guthoff R, Pau HW: [In vivo diagnosis of epithelial changes of the oropharynx using confocal microscopy]. Laryngorhinootologie; 2008 Mar;87(3):174-80
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  • BACKGROUND: Confocal laser scanning microscopy enables the visualization of the anterior regions of the oropharynx mucosa.
  • The investigations were performed on 9 patients with tongue cancer with primary tumor site and stage I (AJCC) and on 12 patients with head and neck cancer who underwent radiochemotherapy (RCT).
  • RESULTS: The following parameters can be detected using LSM: nuclear density, nuclear size, nucleus/cytoplasm relation, number of nuclei, regularity of cell layers, morphology of cells of a cell layer, and occurrence of cellular junctions.
  • After RCT several epithelial changes were found, such as keratosis, mild dysplasia, increased vascularization and more cell edema and necrosis.
  • Both strong hyperplasia and leukoplakia prevent a visualization of the basement cell layer in the oropharynx.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Cell Transformation, Neoplastic / pathology. Leukoplakia, Oral / diagnosis. Microscopy, Confocal. Mouth Neoplasms / diagnosis. Neoplasm Recurrence, Local / diagnosis. Otorhinolaryngologic Neoplasms / diagnosis. Precancerous Conditions / diagnosis. Tongue Neoplasms / diagnosis

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  • (PMID = 17963192.001).
  • [ISSN] 0935-8943
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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34. Brown J, Bekiroglu F, Shaw R: Indications for the scapular flap in reconstructions of the head and neck. Br J Oral Maxillofac Surg; 2010 Jul;48(5):331-7
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  • We have had favourable results in composite resections of the anterior mandible that required substantial resections of the anterior tongue.
  • [MeSH-minor] Aged. Carcinoma, Squamous Cell / surgery. Face / surgery. Female. Humans. Male. Palate, Soft / surgery. Reconstructive Surgical Procedures / methods. Scapula / surgery. Survival Rate. Tongue / surgery

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  • [Copyright] Copyright 2009 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 19913337.001).
  • [ISSN] 1532-1940
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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35. Chen SL, Yu CC, Chang MC, Deng SC, Wu YS, Chen TM: Medial sural artery perforator flap for intraoral reconstruction following cancer ablation. Ann Plast Surg; 2008 Sep;61(3):274-9
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  • Between June 2003 and March 2007, 22 free medial sural artery perforator flaps were transferred for intraoral defects after cancer ablation, including tongue and floor of mouth (15 cases), buccal mucosa (5 cases), retromolar trigone (1 case), and anterior floor of mouth (1 case).
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Mouth Neoplasms / surgery. Reconstructive Surgical Procedures / methods. Surgical Flaps
  • [MeSH-minor] Adult. Aged. Female. Glossectomy / methods. Humans. Male. Middle Aged. Mouth Floor / surgery. Tongue / surgery. Treatment Outcome

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  • (PMID = 18724127.001).
  • [ISSN] 1536-3708
  • [Journal-full-title] Annals of plastic surgery
  • [ISO-abbreviation] Ann Plast Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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36. Tincani AJ, Del Negro A, Araújo PP, Akashi HK, Neves Fda S, Martins AS: Head and neck reconstruction using infrahyoid myocutaneous flaps. Sao Paulo Med J; 2006 Sep 7;124(5):271-4
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  • The anterior floor of the mouth was reconstructed in nine patients (64.2%), the base of tongue in three (21.4%), the lateral floor in one (7.1%), and the retromolar area (7.1%) in one.
  • Thirteen patients (92.8%) had squamous cell carcinoma (SCC) and one (7.2%) ameloblastoma.
  • The disease stage was T3 in eight (61.5%) of the SCC cases and T4 in five (38.5%).
  • The patients with SCC received postoperative radiotherapy without major consequences to the flap.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Head and Neck Neoplasms / surgery. Muscle, Skeletal / transplantation. Reconstructive Surgical Procedures / standards. Surgical Flaps / standards

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  • (PMID = 17262158.001).
  • [ISSN] 1516-3180
  • [Journal-full-title] São Paulo medical journal = Revista paulista de medicina
  • [ISO-abbreviation] Sao Paulo Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
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37. Lkah C, Vacher C: [Use of the pedicled superficial temporoparietal fascial flap for reconstructing soft tissue defects of oral cavity]. Morphologie; 2010 May;94(305):20-5
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  • Two patients have been operated after surgical resection of an oral epidermoid carcinoma.
  • RESULTS: The anatomical study showed that the feasibility of the flap was good, the surface of the flap was 12 x 12 centimetres, and the temporal ramus of the facial nerve was easy to preserve if the dissection was prudent in the anterior part of the flap.
  • [MeSH-minor] Carcinoma, Squamous Cell / surgery. Cheek / pathology. Cheek / surgery. Dissection / methods. Facial Nerve / surgery. Humans. Tongue / surgery. Zygoma / surgery

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  • [Copyright] Copyright 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20303310.001).
  • [ISSN] 1286-0115
  • [Journal-full-title] Morphologie : bulletin de l'Association des anatomistes
  • [ISO-abbreviation] Morphologie
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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38. Taira Y, Sekine J, Sawase T, Atsuta M: Implant-retained overdenture following hemiglossectomy: a 10-year clinical case report. J Oral Rehabil; 2006 Apr;33(4):313-5

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  • Four Brånemark system implants were inserted into the anterior part of the mandible, but one of the four fixtures did not show osseointegration.
  • [MeSH-minor] Carcinoma, Squamous Cell / surgery. Dental Implantation, Endosseous / methods. Humans. Male. Mandible. Middle Aged. Postoperative Complications. Prosthesis Design. Tongue Neoplasms / surgery. Treatment Outcome

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  • (PMID = 16629887.001).
  • [ISSN] 0305-182X
  • [Journal-full-title] Journal of oral rehabilitation
  • [ISO-abbreviation] J Oral Rehabil
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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39. Yagi S, Nakayama B, Kamei Y, Takahashi M, Torii S: Posterolateral cervical vein as a recipient vein in reconstructive microvascular surgery of the head and neck. J Reconstr Microsurg; 2007 Jan;23(1):19-23
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  • The authors have noted a potential recipient vein coursing vertically along the anterior ridge of the trapezius muscle.
  • [MeSH-minor] Aged. Carcinoma, Squamous Cell / surgery. Glossectomy. Humans. Male. Mandibular Neoplasms / surgery. Muscle, Skeletal / transplantation. Neck Dissection. Skin Transplantation / methods. Subclavian Vein / anatomy & histology. Tongue Neoplasms / surgery. Veins / surgery

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  • (PMID = 17230316.001).
  • [ISSN] 0743-684X
  • [Journal-full-title] Journal of reconstructive microsurgery
  • [ISO-abbreviation] J Reconstr Microsurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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40. Kazi R, Prasad VM, Kanagalingam J, Georgalas C, Venkitaraman R, Nutting CM, Clarke P, Rhys-Evans P, Harrington KJ: Analysis of formant frequencies in patients with oral or oropharyngeal cancers treated by glossectomy. Int J Lang Commun Disord; 2007 Sep-Oct;42(5):521-32
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  • The existence of any significant difference of F1, F2 and F3 between the two groups using the sustained vowel /i/ and the effects of other factors, namely age, first presentation versus recurrence, site (oral cavity, oropharynx), subsite (anterior two-thirds of the tongue, tongue base), stage, radiation, complication, and neck dissection, were analysed.

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  • (PMID = 17729144.001).
  • [ISSN] 1368-2822
  • [Journal-full-title] International journal of language & communication disorders
  • [ISO-abbreviation] Int J Lang Commun Disord
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
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41. Li B, Li CH, Guo H, Chen J, Wang SX: [Analysis of 27 cases of defect restoration using infrahyoid myocutaneous flap after intraoral cancer surgery]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2008 Nov;43(11):826-9
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  • Seven cases of squamous cell tongue carcinoma, 4 cases of tongue root carcinoma, 16 cases of mouth floor carcinoma.
  • Eleven cases of the reservation vascularized and infrahyoid muscles in the hyoid attachment (combination pedicle), in 16 cases, the arteria and vena thyroidea superior reserved as the pedicle accompanied with the vena jugularis anterior (the axial vessel pedicle); in 21 cases, the distal end of the vena jugularis interna was tied up at the place where the vena facialis communis joins to the vena jugularis interna. and the vena jugularis anterior was reserved within the flap (interference return).

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  • (PMID = 19267973.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] China
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42. Parkins GE, Armah G, Ampofo P: Tumours and tumour-like lesions of the lower face at Korle Bu Teaching Hospital, Ghana--an eight year study. World J Surg Oncol; 2007;5:48
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  • The tumours were predominantly found in the right (43%), anterior (19%) and left (18%) aspects of the lower face.
  • The remainder making up 20% were found in the floor of the mouth, tongue and lips.
  • Seventy eight (45.6%) of the patients presented with lesions that were classified as malignant of which 54 (62%) were diagnosed as squamous cell carcinoma (SCC).
  • Fifty-four (62%) of malignant tumours were squamous cell carcinoma; 58 (93.6%) of the benign odontogenic tumours were classified as ameloblastoma.
  • CONCLUSION: Tumours and tumour-like lesions of the lower face comprising the mandible, tongue and adjacent structures are a diverse group of neoplasm and are seen commonly in practice of Maxillofacial surgery.
  • In the present study, SCC and ameloblastoma were the commonest malignant and benign odontogenic tumours seen respectively; the two representing more than 65% of all tumours.

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  • (PMID = 17484780.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
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  • [Other-IDs] NLM/ PMC1885260
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43. Kurt M, Bulut N, Aksoy S, Kosemehmetoglu K, Kars A: Anterior tongue metastasis from lung cancer. South Med J; 2006 Jul;99(7):784-5
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  • [Title] Anterior tongue metastasis from lung cancer.
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. Lung Neoplasms / pathology. Tongue Neoplasms / secondary

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  • (PMID = 16866071.001).
  • [ISSN] 0038-4348
  • [Journal-full-title] Southern medical journal
  • [ISO-abbreviation] South. Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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44. Mahindra P, DiGiovanna JJ, Tamura D, Brahim JS, Hornyak TJ, Stern JB, Lee CC, Khan SG, Brooks BP, Smith JA, Driscoll BP, Montemarano AD, Sugarman K, Kraemer KH: Skin cancers, blindness, and anterior tongue mass in African brothers. J Am Acad Dermatol; 2008 Nov;59(5):881-6
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  • [Title] Skin cancers, blindness, and anterior tongue mass in African brothers.
  • [MeSH-major] Blindness / etiology. Carcinoma, Squamous Cell / etiology. Skin Neoplasms / complications. Xeroderma Pigmentosum / complications
  • [MeSH-minor] Adolescent. Child, Preschool. Consanguinity. Humans. Male. Photosensitivity Disorders / etiology. Sunlight / adverse effects. Tongue Neoplasms / etiology. Tongue Neoplasms / pathology. Young Adult

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  • (PMID = 19119101.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z01 BC004517-31
  • [Publication-type] Case Reports; Clinical Conference; Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS75463; NLM/ PMC2717011
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