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Items 1 to 30 of about 30
1. Kannan J, Karkuzhali P, Lakshminarasimhan S: Thymic seminoma. Indian J Med Paediatr Oncol; 2009 Jan;30(1):46-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Thymic seminoma.
  • Thymic seminoma is a rare clinical entity.
  • Contrast-enhanced computer tomogram of chest showed an anterior mediastinal mass.
  • Histopathology examination revealed seminoma of thymus.

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  • (PMID = 20668609.001).
  • [ISSN] 0975-2129
  • [Journal-full-title] Indian journal of medical and paediatric oncology : official journal of Indian Society of Medical & Paediatric Oncology
  • [ISO-abbreviation] Indian J Med Paediatr Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2902217
  • [Keywords] NOTNLM ; Thymic seminoma / anterior mediastinal mass / thoracotomy
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2. Khan FY, Al Ani A, Allaithy MS, Al-Bozom IA: A young male with shortness of breath. Ann Thorac Med; 2008 Jan;3(1):28-30

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We report a case of primary mediastinal seminoma, which presented initially with shortness of breath and a swelling in upper part of anterior chest wall.
  • The diagnosis of primary mediastinal seminoma was established on the basis of histologic findings and was confirmed by immunohistochemical analysis.

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  • (PMID = 19561881.001).
  • [ISSN] 1817-1737
  • [Journal-full-title] Annals of thoracic medicine
  • [ISO-abbreviation] Ann Thorac Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2700432
  • [Keywords] NOTNLM ; Extragonadal seminoma / mediastinal seminoma
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3. Tanabe T, Yasuo M, Tsushima K, Urushihata K, Yamamoto H, Hanaoka M, Koizumi T, Fujimoto K, Yamazaki Y, Hirose Y, Hamano H, Sakurai A, Kubo K: Mediastinal seminoma in a patient with multiple endocrine neoplasia type 1. Intern Med; 2008;47(18):1615-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mediastinal seminoma in a patient with multiple endocrine neoplasia type 1.
  • A patient with multiple endocrine neoplasia type 1 (MEN1) developed a mediastinal seminoma.
  • A diagnosis of mediastinal seminoma was pathologically confirmed and a complete remission was achieved by chemotherapy.
  • A diagnosis of MEN1 was made genetically.
  • Although patients with MEN1 manifest a variety of neoplastic disorders, no cases of concurrent seminoma and MEN1 have previously been reported.
  • In addition, no etiological relationship between seminoma and MEN1 has yet been reported.
  • [MeSH-major] Mediastinal Neoplasms / diagnosis. Multiple Endocrine Neoplasia Type 1 / diagnosis. Neoplasms, Multiple Primary / diagnosis. Seminoma / diagnosis


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4. Hapani S, Chu D, Wu S: Eosinophilic pneumonia associated with bleomycin in a patient with mediastinal seminoma: a case report. J Med Case Rep; 2010;4:126

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Eosinophilic pneumonia associated with bleomycin in a patient with mediastinal seminoma: a case report.
  • CASE PRESENTATION: A 44-year-old Hispanic man with a primary mediastinal seminoma complicated by superior vena cava syndrome underwent treatment with four cycles of bleomycin, etoposide and cisplatin.

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  • (PMID = 20429899.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2868877
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5. Kim DW, Jung SA, Park SA, Kim CG: Accumulation of bone-seeking agent in a patient with mediastinal seminoma. Clin Nucl Med; 2010 Oct;35(10):836-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Accumulation of bone-seeking agent in a patient with mediastinal seminoma.
  • Bone scan revealed a large soft-tissue uptake in anterior chest.
  • Subsequent computed tomography showed a large mass lesion with well demarcated margins in anterior mediastinum.
  • Percutaneous core needle biopsy and histopathologic examination diagnosed the mediastinal seminoma.
  • [MeSH-major] Bone and Bones / radionuclide imaging. Mediastinal Neoplasms / metabolism. Seminoma / metabolism

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  • (PMID = 20838305.001).
  • [ISSN] 1536-0229
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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6. Yang CJ, Cheng MS, Chou SH, Tsai KB, Huang MS: Primary germ cell tumors of the mediastinum: 10 years of experience in a tertiary teaching hospital. Kaohsiung J Med Sci; 2005 Sep;21(9):395-400

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary germ cell tumors of the mediastinum: 10 years of experience in a tertiary teaching hospital.
  • Extragonadal germ cell tumors are rare, and most occur in the retroperitoneum and mediastinum.
  • Primary mediastinal germ cell tumors are often found in the anterior portion of the mediastinum and include teratomas and non-teratomatous tumors.
  • Teratomas are the most common germ cell tumors of the mediastinum, and seminomas are the most common non-teratomatous germ cell tumors of the mediastinum.
  • Cases of primary mediastinal MNSGCT reported in the literature are rare.
  • In this report, we review all primary mediastinal germ cell tumors from a 10-year period at the Chung-Ho Memorial Hospital of Kaohsiung Medical University.
  • A total of 14 cases were reviewed, including 11 patients with mature teratomas, two with yolk sac tumors, and one with seminoma.
  • [MeSH-major] Germinoma / diagnosis. Mediastinal Neoplasms / diagnosis

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  • (PMID = 16248122.001).
  • [ISSN] 1607-551X
  • [Journal-full-title] The Kaohsiung journal of medical sciences
  • [ISO-abbreviation] Kaohsiung J. Med. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China (Republic : 1949- )
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7. Ashkenazi D, Peretz S: [Cervical mass as an isolated finding in primary mediastinal seminoma]. Harefuah; 2007 Dec;146(12):932-4, 999
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Cervical mass as an isolated finding in primary mediastinal seminoma].
  • Seminoma is a malignant tumor of germ cell origin, usually found in male gonads.
  • Primary seminoma of the mediastinum is rare.
  • The natural history of mediastinal seminoma is growth which is asymptomatic until a late stage, and therefore when diagnosed it is large and causes symptoms of cough, hoarseness and chest pain.
  • This is a case history of a patient referred for evaluation of a mass in the lower neck, which proved to be a direct extension of the primary anterior mediastinal tumor.
  • The tumor was diagnosed pathologically as a primary mediastinal seminoma.
  • Despite the findings of a massive tumor in the mediastinum, the patient had no complaints.
  • [MeSH-major] Mediastinal Neoplasms / pathology. Seminoma / pathology. Testicular Neoplasms / pathology

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  • (PMID = 18254443.001).
  • [ISSN] 0017-7768
  • [Journal-full-title] Harefuah
  • [ISO-abbreviation] Harefuah
  • [Language] heb
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Israel
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8. Fatimi SH, Shahid B, Hanif HM, Muzaffar M: Mediastinal seminoma presenting as superior vena cava syndrome and tracheal obstruction. J Pak Med Assoc; 2010 Oct;60(10):861-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mediastinal seminoma presenting as superior vena cava syndrome and tracheal obstruction.
  • Malignant germ cell tumours of the mediastinum are rare, presenting mostly in young males.
  • Occasionally, mediastinal adenopathy and superior vena cava (SVC) syndrome may occur.
  • CT scan chest showed a large mediastinal mass 18 x 24 cm extending from the superior mediastinum to the mid pericardial area.
  • [MeSH-major] Airway Obstruction / etiology. Mediastinal Neoplasms / pathology. Seminoma / pathology. Superior Vena Cava Syndrome / etiology. Tracheal Diseases / etiology
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bleomycin / administration & dosage. Cisplatin / administration & dosage. Diagnosis, Differential. Etoposide / administration & dosage. Humans. Male. Sternotomy. Tomography, X-Ray Computed. Treatment Outcome. Young Adult


9. Kwon MS: Aspiration cytology of mediastinal seminoma: report of a case with emphasis on the diagnostic role of aspiration cytology, cell block and immunocytochemistry. Acta Cytol; 2005 Nov-Dec;49(6):669-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Aspiration cytology of mediastinal seminoma: report of a case with emphasis on the diagnostic role of aspiration cytology, cell block and immunocytochemistry.
  • BACKGROUND: Medigstinal seminoma ia an uncommon tumor that occurs primarily in young males.
  • We present a case of mediastinal seminoma in an elderly male diagnosed on fine needle aspiration (FNA) tytology.
  • CASE: A 62-year-old male was admitted to our hospital because of anterior chest pain for 2 weeks.
  • Chest computed tomography revealed a huge, lobulated mass in the anterior mediastinum.
  • CONCLUSION: A confident diagnosis of mediastinal seminoma can be established by FNA cytology, cell block and immunocytochemistry.
  • [MeSH-major] Mediastinal Neoplasms / diagnosis. Seminoma / diagnosis

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  • (PMID = 16450911.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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10. Launay M, Bozzolo E, Venissac N, Delmont E, Fredenrich A, Thomas P: [Paraneoplastic limbic encephalitis with positive anti-RI antibodies and mediastinal seminoma]. Rev Neurol (Paris); 2008 Jun-Jul;164(6-7):612-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Paraneoplastic limbic encephalitis with positive anti-RI antibodies and mediastinal seminoma].
  • Anti-RI antibodies were positive, leading to the diagnosis of paraneoplastic limbic encephalitis.
  • Surgical resection revealed an ectopic mediastinal seminoma.
  • This case of paraneoplastic limbic encephalitis associated with positive anti-RI antibodies and mediastinal seminoma is exceptional and has not to our knowledge been described in the literature.

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  • (PMID = 18565362.001).
  • [ISSN] 0035-3787
  • [Journal-full-title] Revue neurologique
  • [ISO-abbreviation] Rev. Neurol. (Paris)
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Antibodies, Neoplasm; 0 / Antigens, Neoplasm; 0 / Biomarkers; 0 / Nerve Tissue Proteins; 0 / Nova antigen; 0 / RNA-Binding Proteins
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11. Roberto Silva J, Carragoso A, Gaspar O: [Mediastinal seminoma: in reference to a case report]. Rev Port Pneumol; 2008 Sep-Oct;14(5):705-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Mediastinal seminoma: in reference to a case report].
  • [Transliterated title] Seminoma mediastínico: A propósito de um caso clínico.
  • In reference to a clinical report, the authors of this article make a review about semiology, diagnosis and treatment of mediastinal seminoma.
  • [MeSH-major] Mediastinal Neoplasms / diagnosis. Seminoma / diagnosis

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  • (PMID = 18781271.001).
  • [ISSN] 0873-2159
  • [Journal-full-title] Revista portuguesa de pneumologia
  • [ISO-abbreviation] Rev Port Pneumol
  • [Language] por
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Portugal
  • [Number-of-references] 5
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12. Tsai CK, Huang TW, Li CC, Hsieh CM, Lee SC, Cheng YL, Lee HS: Cystic seminoma with elevated value of carbohydrate antigen 19-9 in tumor fluid mimicking cystic teratoma. Ann Thorac Surg; 2009 Nov;88(5):1693-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cystic seminoma with elevated value of carbohydrate antigen 19-9 in tumor fluid mimicking cystic teratoma.
  • The incidence of cystic lesions of anterior mediastinum is low, which is responsible for approximately 10% of anterior mediastinal tumors.
  • We presented a special case of primary anterior mediastinal tumor with both prominent cystic change and extreme high carbohydrate antigen 19-9 level of cystic fluid here.
  • From the finding of this case report, we suggested that the diagnosis of cystic anterior mediastinal tumors should include both cystic seminoma and mature cystic teratoma.
  • [MeSH-major] Mediastinal Neoplasms / chemistry. Mediastinal Neoplasms / diagnosis. Seminoma / chemistry. Seminoma / diagnosis. Teratoma / chemistry. Teratoma / diagnosis
  • [MeSH-minor] Body Fluids / chemistry. CA-19-9 Antigen / analysis. Diagnosis, Differential. Humans. Male. Young Adult

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  • (PMID = 19853145.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / CA-19-9 Antigen
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13. Majewski W, Majewski S, Maciejewski A, Kolosza Z, Tarnawski R: Adverse effects after radiotherapy for early stage (I,IIa,IIb) seminoma. Radiother Oncol; 2005 Sep;76(3):257-63
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adverse effects after radiotherapy for early stage (I,IIa,IIb) seminoma.
  • BACKGROUND AND PURPOSE: The evaluation of adverse effects after radiotherapy for early stage (I,IIa,IIb) seminoma.
  • PATIENTS AND METHODS: A retrospective analysis of 164 patients with stage I, IIa, IIb seminoma treated with post-orchidectomy irradiation, between 1974 and 1990 was performed.
  • Patients had been treated with infradiaphragmatic radiotherapy only (IDRT) in 48%, and prophylactic mediastinal and left supraclavicular irradiation (supradiaphragmatic radiotherapy, SDRT) was performed additionally in the remaining 52% of patients.
  • CONCLUSIONS: Excessive dose maximum in normal tissues from each fraction to anterior mediastinum is associated with increased cardiac morbidity.
  • [MeSH-major] Radiation Injuries. Seminoma / radiotherapy. Testicular Neoplasms / radiotherapy

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  • (PMID = 15921773.001).
  • [ISSN] 0167-8140
  • [Journal-full-title] Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
  • [ISO-abbreviation] Radiother Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
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14. Qiu S, Luna MA: Testicular seminoma metastasizing to the parotid gland: report of a case. Head Neck; 2005 Oct;27(10):923-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Testicular seminoma metastasizing to the parotid gland: report of a case.
  • METHODS: We present a case of testicular seminoma metastasizing to the parotid gland.
  • The patient, who had a remote history of testicular seminoma, was initially seen with a parotid mass.
  • The diagnosis of testicular seminoma metastasizing to the parotid gland was established on the basis of histologic findings and was confirmed by immunohistochemical analysis.
  • Extragonadal seminoma often occurs in the midline (presacral, retroperitoneal, anterior mediastinal, and pineal regions); when present in any other locations, the tumor should be considered to be metastatic.
  • Placenta alkaline phosphatase is a useful immunohistochemical stain to confirm the diagnosis, and cytokeratin immunohistonegativity rules out carcinomas or epithelioid sarcomas.
  • CONCLUSIONS: To our knowledge, this is the first published case of metastatic testicular seminoma to the parotid gland.
  • Cytomorphologic features of seminoma and the presence of granulomatous giant cells are important diagnostic clues.
  • Two other neoplasms with granulomatous reactions, nasopharyngeal carcinoma and epithelioid sarcoma, should be considered in the differential diagnosis.
  • [MeSH-major] Parotid Neoplasms / secondary. Seminoma / secondary. Testicular Neoplasms / pathology

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  • [Copyright] (c) 2005 Wiley Periodicals, Inc.
  • (PMID = 15920749.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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15. Zhou JF, Bai CM, Yang D, Chen SC: [Clinical analysis of primary mediastinal germ cell tumors]. Zhonghua Zhong Liu Za Zhi; 2007 Jul;29(7):531-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinical analysis of primary mediastinal germ cell tumors].
  • OBJECTIVE: To investigate the clinical and pathological features, optimal treatment and prognostic factor in primary mediastinal germ cell tumors (PMGCT).
  • RESULTS: All the 29 patients were male with a mean age of 26.1 +/- 9.6 years at diagnosis.
  • All tumors were originated from the anterior mediastinum with a mean diameter of 16.0 +/- 5.2 cm.
  • There were 5 (17.2%) primary mediastinal seminomas (PMSGCT) and 24 (82.8%) primary mediastinal nonseminomas (PMNSGCT) in this series.
  • Cox multivariate analysis indicated that limited mediastinal disease at diagnosis (P = 0.004) and the use of cisplatin-based combined chemotherapy (P = 0.005) were independent good prognostic factors of PMNSGCT.
  • CONCLUSION: Primary mediastinal nonseminoma constitutes the most of primary mediastinal germ cell tumors.
  • Cisplatin-based combined chemotherapy may be the most effective for the treatment of primary mediastinal germ cell tumors.
  • The prognosis of primary mediastinal nonseminomas is significantly worse than that of primary mediastinal seminomas, and correlated with the extent of disease and chemotherapy.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Mediastinal Neoplasms / therapy. Neoplasms, Germ Cell and Embryonal / therapy. Seminoma / therapy
  • [MeSH-minor] Adolescent. Adult. Bleomycin / therapeutic use. Child. Cisplatin / therapeutic use. Combined Modality Therapy. Etoposide / therapeutic use. Follow-Up Studies. Humans. Ifosfamide / therapeutic use. Male. Mediastinum / surgery. Middle Aged. Remission Induction. Retrospective Studies. Survival Rate. Taxoids / therapeutic use. Young Adult

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  • (PMID = 18069635.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Taxoids; 11056-06-7 / Bleomycin; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin; UM20QQM95Y / Ifosfamide; BEP protocol; TIP regimen
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16. Lin MW, Chang YL, Wu CT, Lee YC: Video-assisted thoracoscopic surgery for a cystic seminoma of the mediastinum. Ann Thorac Surg; 2010 Dec;90(6):2041-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Video-assisted thoracoscopic surgery for a cystic seminoma of the mediastinum.
  • Mediastinal seminomas are uncommon primary mediastinal neoplasms, and most are solid in appearance.
  • Cystic mediastinal seminoma is an unusual type of extragonadal germ cell tumor that has rarely been reported in the literature.
  • Here we describe a 36-year-old man with a 7.5-cm cystic mediastinal seminoma.
  • [MeSH-major] Cysts / surgery. Mediastinal Neoplasms / surgery. Seminoma / surgery. Testicular Neoplasms / pathology. Thoracic Surgery, Video-Assisted / methods
  • [MeSH-minor] Adult. Diagnosis, Differential. Follow-Up Studies. Humans. Male. Photomicrography. Radiography, Thoracic. Tomography, X-Ray Computed

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  • [Copyright] Copyright © 2010 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.
  • (PMID = 21095363.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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17. Song SY, Ko YH, Ahn G: Mediastinal germ cell tumor associated with histiocytic sarcoma of spleen: case report of an unusual association. Int J Surg Pathol; 2005 Jul;13(3):299-303
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  • [Title] Mediastinal germ cell tumor associated with histiocytic sarcoma of spleen: case report of an unusual association.
  • We present an unusual association of mediastinal germ cell tumor containing seminoma and angiosarcoma components and splenic histiocytic sarcoma.
  • Histopathologically, an anterior mediastinal mass contained typical seminoma, immature teratoma, embryonal carcinoma, angiosarcoma, yolk sac tumor, and polyembryoma.
  • [MeSH-major] Hemangiosarcoma / pathology. Histiocytic Sarcoma / pathology. Mediastinal Neoplasms / pathology. Seminoma / pathology. Splenic Neoplasms / pathology

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  • (PMID = 16086090.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin; BEP protocol
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18. Abid L, Ayadi-Kaddour A, Braham E, Smati B, Ismail O, Kilani T, El Mezni F: [Primary mediastinal seminoma. Report of three cases]. Tunis Med; 2007 Jan;85(1):74-7
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  • [Title] [Primary mediastinal seminoma. Report of three cases].
  • [Transliterated title] Seminome primitif du mediastin. A propos de trois cas.
  • BACKGROUND: Primary mediastinal seminomas (PMS) are rare tumors that are morphologically similar to their testicular counterparts but may have different biologic behavior due to their particular anatomical location.
  • AIM: New cases report of PMS CASES: Three new cases of primary mediastinal seminoma are presented.
  • Mediastinoscopic biopsy was performed and histological examination results revealed a seminoma.
  • Chemotherapy has largely replaced surgical resection and radiotherapy as the initial treatment in patients with mediastinal seminoma.
  • [MeSH-major] Mediastinal Neoplasms. Seminoma
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biopsy. Combined Modality Therapy. Follow-Up Studies. Humans. Immunohistochemistry. Male. Mediastinum / pathology. Middle Aged. Radiography, Thoracic. Radiotherapy Dosage. Time Factors. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 17424717.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Tunisia
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19. Ayyanar K, Blackman SC, Chordas C, Frazier L, Kieran MW: Metachronous mediastinal seminoma occurring after intracranial germinoma in an adolescent. J Pediatr Hematol Oncol; 2009 Nov;31(11):861-4
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  • [Title] Metachronous mediastinal seminoma occurring after intracranial germinoma in an adolescent.
  • We report a case of a mediastinal seminoma occurring 19 months after the resolution of a pineal germinoma.
  • A mediastinal seminoma (germinoma) was diagnosed nearly 2 years later because of rising serum beta-HCG.
  • The patient underwent systemic chemotherapy with the complete resolution of the mediastinal seminoma.
  • [MeSH-major] Germinoma / radiotherapy. Mediastinal Neoplasms / drug therapy. Neoplasms, Second Primary / drug therapy. Pinealoma / radiotherapy. Seminoma / drug therapy

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  • (PMID = 19779380.001).
  • [ISSN] 1536-3678
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chorionic Gonadotropin, beta Subunit, Human
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20. Iwasa S, Ando M, Ono M, Hirata T, Yunokawa M, Nakano E, Yonemori K, Kouno T, Shimizu C, Tamura K, Katsumata N, Fujiwara Y: Relapse with malignant transformation after chemotherapy for primary mediastinal seminoma: case report. Jpn J Clin Oncol; 2009 Jul;39(7):456-9
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  • [Title] Relapse with malignant transformation after chemotherapy for primary mediastinal seminoma: case report.
  • This case report details a relapse with malignant transformation after the completion of bleomycin, etoposide and cisplatin chemotherapy for primary mediastinal seminoma, although the residual mass after chemotherapy was <3 cm in size and did not display an increased uptake of fluorodeoxyglucose when examined using positron emission tomography.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Mediastinal Neoplasms / drug therapy. Neoplasm Recurrence, Local / etiology. Seminoma / drug therapy

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  • (PMID = 19395465.001).
  • [ISSN] 1465-3621
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18; 11056-06-7 / Bleomycin; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin
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21. Miyawaki M, Miura T, Imakire T, Kawano Y, Kawahara K, Ikewaki J, Ogata M: [High-dose chemotherapy with peripheral blood stem cell auto transplantation for an intractable case of mediastinal seminoma]. Gan To Kagaku Ryoho; 2006 Jun;33(6):845-8
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  • [Title] [High-dose chemotherapy with peripheral blood stem cell auto transplantation for an intractable case of mediastinal seminoma].
  • We encountered an intractable case of mediastinal seminoma treated by HDC with PBSCT.
  • The patient was a 25-year-old man with mediastinal seminoma.
  • He had undergone chemo-radiotherapy several times and salvage surgery for the mediastinal tumor and chest wall recurrence since September 2001.
  • He was referred to our clinic for management of recurrent seminoma in the chest wall in January 2004.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Mediastinal Neoplasms / therapy. Peripheral Blood Stem Cell Transplantation. Seminoma / therapy

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  • (PMID = 16770111.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 143011-72-7 / Granulocyte Colony-Stimulating Factor; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin; VP-P protocol
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22. Sung MT, Maclennan GT, Lopez-Beltran A, Zhang S, Montironi R, Cheng L: Primary mediastinal seminoma: a comprehensive assessment integrated with histology, immunohistochemistry, and fluorescence in situ hybridization for chromosome 12p abnormalities in 23 cases. Am J Surg Pathol; 2008 Jan;32(1):146-55
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary mediastinal seminoma: a comprehensive assessment integrated with histology, immunohistochemistry, and fluorescence in situ hybridization for chromosome 12p abnormalities in 23 cases.
  • Accurate diagnosis of mediastinal seminoma is critical because of its favorable response to radiation therapy and/or cisplatin-based chemotherapy.
  • Immunohistochemical staining for OCT4 has recently been validated as a powerful tool for detecting gonadal seminoma.
  • However, discrepancies between the genetic alterations and immunoprofiles of mediastinal and testicular seminomas have been reported, raising the question of whether techniques that are useful in the diagnosis of gonadal seminoma are applicable to its mediastinal counterpart.
  • The present study was conducted to evaluate the morphologic and immunohistochemical characteristics and chromosomal abnormalities of 12p in 23 primary mediastinal seminomas and to compare their applicability as diagnostic tools.
  • Lymphocytic infiltration is the most common histologic feature observed in primary mediastinal seminoma and both OCT4 immunostain and FISH for 12p abnormalities can be very helpful in diagnosing mediastinal seminoma.
  • The intense staining pattern of OCT4 and the high sensitivity of FISH make them superior to other auxiliary diagnostic utilities for detecting seminoma.
  • In addition, the incidences of cytokeratin expression of primary mediastinal seminoma are similar to those of its gonadal counterpart and pathologists must exercise caution in the interpretation of epithelial markers in mediastinal neoplasms.
  • [MeSH-major] Chromosomes, Human, Pair 12 / genetics. Mediastinal Neoplasms / genetics. Mediastinal Neoplasms / pathology. Seminoma / genetics. Seminoma / pathology

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  • (PMID = 18162782.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Octamer Transcription Factor-3; 0 / POU5F1 protein, human
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23. Jung SM, Chu PH, Shiu TF, Wu HH, Kuo TT, Chu JJ, Lin PJ: Expression of OCT4 in the primary germ cell tumors and thymoma in the mediastinum. Appl Immunohistochem Mol Morphol; 2006 Sep;14(3):273-5
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  • [Title] Expression of OCT4 in the primary germ cell tumors and thymoma in the mediastinum.
  • Primary germ cell tumors (GCTs) and thymoma are both located in the anterior mediastinum.
  • This study examined OCT4 expression in GCTs and thymoma originating from the mediastinum.
  • A retrospective study included 46 consecutive patients with GCTs conducted between 1983 and 2005, and 22 consecutive thymoma in the mediastinum whose tumors had been surgically excised.
  • The 46 primary GCTs in mediastinum included teratoma (n=27; 58.7%), seminoma (n=10; 21.7%), yolk sac tumor (n=6; 13%), embryonal carcinoma (n=1; 2.1%), and mixed GCTs (n=2; 4%; one consisted of teratoma and yolk sac tumor, and the other teratoma, yolk sac tumor, and seminoma); and 22 thymoma including World Health Organization type A (n=3, 13.6%), type AB (n=4, 18.2%), type B1 (n=6, 27.3%), type B2 (n=4, 13.6%), and type B3 (n=5, 22.7%).
  • All 10 seminoma cases, 1 embryonal carcinoma case, and 1 mixed GCT case containing seminoma were immunopositive for OCT4.
  • On the other hand, the 22 thymoma, 6 yolk sac tumor, 27 teratomas, and 1 case with mixed GCT without component of seminoma were immunonegative for OCT4.
  • We conclude that immunostaining with antibodies to OCT4 is a useful diagnostic tool in the identification of seminomas and primary embryonal carcinomas in GCTs originating from the mediastinum.

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  • (PMID = 16932017.001).
  • [ISSN] 1541-2016
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Congresses; Evaluation Studies; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Biomarkers, Tumor; 0 / OKT4A monoclonal antibody
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24. Jegannathen A, Taylor MB, Jones M, Logue JP: Testicular seminoma with mediastinal lymphadenopathy -- a diagnostic pitfall. Br J Radiol; 2009 May;82(977):e85-6
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  • [Title] Testicular seminoma with mediastinal lymphadenopathy -- a diagnostic pitfall.
  • Relapse following adjuvant paraaortic radiation therapy in patients with Stage I seminoma is rare, occurring in approximately 4% of men.
  • The majority of relapses are sited in the pelvis but relapse in the mediastinum is also recognised.
  • However, there are reports of the association of testicular cancers with sarcoidosis and sarcoid-like processes in the mediastinum, emphasising the importance of making histological diagnosis prior to commencement of any treatment.
  • We report on two men treated for testicular seminoma who on follow-up developed mediastinal lymphadenopathy, which was initially assumed to be metastatic seminoma.
  • [MeSH-major] Lymphatic Diseases / pathology. Mediastinal Diseases / pathology. Mediastinum / pathology. Sarcoidosis / pathology
  • [MeSH-minor] Adult. Biopsy. Diagnosis, Differential. Humans. Male. Mediastinoscopy. Seminoma / radiotherapy. Seminoma / secondary. Testicular Neoplasms / pathology. Testicular Neoplasms / radiotherapy. Tomography, X-Ray Computed

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  • (PMID = 19386953.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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25. Kamezaki K, Fukuda T, Makino S, Harada M: Cyclophosphamide-induced cardiomyopathy in a patient with seminoma and a history of mediastinal irradiation. Intern Med; 2005 Feb;44(2):120-3
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  • [Title] Cyclophosphamide-induced cardiomyopathy in a patient with seminoma and a history of mediastinal irradiation.
  • A 17-year-old man with mediastinal seminoma was treated with chemotherapy and mediastinal irradiation therapy.
  • It is suggested that the history of mediastinal irradiation was responsible for the onset of cardiomyopathy.
  • [MeSH-major] Antineoplastic Agents, Alkylating / adverse effects. Cardiomyopathies / chemically induced. Cyclophosphamide / adverse effects. Mediastinal Neoplasms / radiotherapy. Seminoma / therapy. Testicular Neoplasms / therapy

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  • [CommentIn] Intern Med. 2005 Feb;44(2):89-90 [15750266.001]
  • (PMID = 15750271.001).
  • [ISSN] 0918-2918
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 8N3DW7272P / Cyclophosphamide
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26. Goichot B, Vinzio S, Massard G, Thompson M: An unusual cause of anterior mediastinal mass: thymic hyperplasia resulting from Graves disease. Am J Clin Oncol; 2006 Jun;29(3):322-3
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  • [Title] An unusual cause of anterior mediastinal mass: thymic hyperplasia resulting from Graves disease.
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Hyperplasia. Male. Mediastinum / pathology. Seminoma / complications. Seminoma / pathology. Testicular Neoplasms / complications. Testicular Neoplasms / pathology

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  • (PMID = 16755190.001).
  • [ISSN] 1537-453X
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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27. Terada T: Mediastinal seminoma with multiple KIT gene mutations. Pathology; 2009;41(7):695-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mediastinal seminoma with multiple KIT gene mutations.
  • [MeSH-major] Mediastinal Neoplasms / diagnosis. Mutation. Proto-Oncogene Proteins c-kit / genetics. Seminoma / diagnosis. Testicular Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Biomarkers, Tumor / metabolism. Combined Modality Therapy. DNA Mutational Analysis. DNA, Neoplasm / analysis. Humans. Incidental Findings. Male. Mediastinum / radiography. Receptor, Platelet-Derived Growth Factor alpha / genetics

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  • (PMID = 20001354.001).
  • [ISSN] 1465-3931
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor alpha
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28. Hervé F, Debled M, Houdent C, Levesque H, Marie I: Cold agglutinin disease revealing mediastinal seminoma. QJM; 2007 May;100(5):311-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cold agglutinin disease revealing mediastinal seminoma.
  • [MeSH-major] Mediastinal Neoplasms / complications. Seminoma / complications

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  • (PMID = 17449873.001).
  • [ISSN] 1460-2725
  • [Journal-full-title] QJM : monthly journal of the Association of Physicians
  • [ISO-abbreviation] QJM
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
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29. Holdhoff M, Wung PK, Petronis JD, Couzi R: Persistent positron emission tomography-positive liver lesions after successful chemotherapy in mediastinal seminoma. J Clin Oncol; 2007 Jun 10;25(17):2482-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Persistent positron emission tomography-positive liver lesions after successful chemotherapy in mediastinal seminoma.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Liver Diseases / radionuclide imaging. Liver Neoplasms / secondary. Mediastinal Neoplasms / pathology. Seminoma / secondary

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  • [Cites] J Clin Oncol. 2002 Apr 1;20(7):1864-73 [11919246.001]
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  • (PMID = 17557961.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA006973
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin
  • [Other-IDs] NLM/ NIHMS573277; NLM/ PMC4036441
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30. Bedano PM, Bonnin J, Einhorn LH: Metachronous intracranial germinoma in a patient with a previous primary mediastinal seminoma. J Clin Oncol; 2006 May 20;24(15):2386-7
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  • [Title] Metachronous intracranial germinoma in a patient with a previous primary mediastinal seminoma.
  • [MeSH-major] Brain Neoplasms / diagnosis. Germinoma / diagnosis. Mediastinal Neoplasms / diagnosis. Neoplasms, Second Primary / diagnosis. Seminoma / diagnosis
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bleomycin / administration & dosage. Cisplatin / administration & dosage. Combined Modality Therapy. Etoposide / administration & dosage. Humans. Ifosfamide / administration & dosage. Male. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / therapy. Neurosurgical Procedures. Radiotherapy. Vinblastine / administration & dosage

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  • (PMID = 16710037.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; 5V9KLZ54CY / Vinblastine; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin; UM20QQM95Y / Ifosfamide
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