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1. Martín de Nicolás J, Gómez-Caro Andrés A, Moradiellos Díez FJ, Díaz-Hellín V, Gigirey Castro O, Larrú Cabrero E, Pérez Antón JA, Marrón Fernández C: [Importance of routine mediastinal staging in women with non-small cell lung cancer]. Arch Bronconeumol; 2005 Mar;41(3):125-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Importance of routine mediastinal staging in women with non-small cell lung cancer].
  • [Transliterated title] Importancia de la estadificación mediastínica, sistemática en mujeres con carcinoma broncogénico, no microcítico.
  • OBJECTIVE: To study the specific importance of mediastinal staging in women with nonsmall cell lung cancer.
  • Cervical mediastinoscopy was performed in all cases, with the addition of anterior mediastinotomy in cases with left upper lobe involvement.
  • RESULTS: Cervical mediastinoscopy was performed on all 108 patients, 26 of whom also underwent anterior mediastinotomy.
  • The percentage of positive findings was significantly higher for cases with adenocarcinoma or large cell carcinoma (P<.05).
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / pathology. Lung Neoplasms / pathology. Mediastinoscopy. Neoplasm Staging
  • [MeSH-minor] Adenocarcinoma / pathology. Carcinoma, Large Cell / pathology. Carcinoma, Squamous Cell / pathology. Chi-Square Distribution. Data Interpretation, Statistical. Female. Humans. Pneumonectomy. Radiography, Thoracic. Sex Factors. Thoracotomy. Tomography, X-Ray Computed


2. Fernando SR, Van Tornout F, Ball RY, Wimperis JZ: Spontaneous mediastinal haemorrhage linked with thymic carcinoma and myelodysplasia: a case report. Cases J; 2009;2:7821

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spontaneous mediastinal haemorrhage linked with thymic carcinoma and myelodysplasia: a case report.
  • We report an unusual sequence of clinico-pathological manifestations of myelodysplastic syndrome and thymic squamous cell carcinoma.
  • Radiological investigations revealed an anterior mediastinal mass, associated with mediastinal haemorrhage.
  • The mass was excised via a standard median sternotomy and was found to be an infiltrating squamous cell carcinoma, which arose from a multilocular thymic cyst.

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  • (PMID = 19830017.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2740167
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3. Thomas JG, Kashani R, Balter JM, Tatro D, Kong FM, Pan CC: Intra and interfraction mediastinal nodal region motion: implications for internal target volume expansions. Med Dosim; 2009;34(2):133-9
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  • [Title] Intra and interfraction mediastinal nodal region motion: implications for internal target volume expansions.
  • The purpose of this study was to determine the intra and interfraction motion of mediastinal lymph node regions.
  • Ten patients with nonsmall-cell lung cancer underwent controlled inhale and exhale computed tomography (CT) scans during two sessions (40 total datasets) and mediastinal nodal stations 1-8 were outlined.
  • Corresponding CT scans from different sessions were registered to remove setup error and, in this reference frame, the centroid of each nodal station was compared for right-left (RL), anterior-posterior (AP), and superior-inferior (SI) displacement.
  • Mediastinal lymph node regions clearly move during breathing.
  • This study indicates the potential advantage of characterizing individualized nodal region motion to safely maximize conformality of mediastinal nodal targets.

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  • (PMID = 19410142.001).
  • [ISSN] 1873-4022
  • [Journal-full-title] Medical dosimetry : official journal of the American Association of Medical Dosimetrists
  • [ISO-abbreviation] Med Dosim
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA059827-089004; United States / NCI NIH HHS / CA / P01 CA059827; United States / NCI NIH HHS / CA / P01 CA059827-089004; United States / NCI NIH HHS / CA / P01-CA59827
  • [Publication-type] Clinical Trial; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS109932; NLM/ PMC2714530
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4. Wang LY, Wu MZ, Yen RF, Tzen KY: Asymptomatic thymic carcinoma with solitary hepatic metastasis detected by fluorodeoxyglucose positron emission tomography. J Formos Med Assoc; 2009 Aug;108(8):677-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Asymptomatic thymic carcinoma with solitary hepatic metastasis detected by fluorodeoxyglucose positron emission tomography.
  • Thymic carcinoma is a rare anterior mediastinal malignancy.
  • Thymic carcinoma is aggressive and tends to metastasize to the lymph nodes, lungs, and bones, and less commonly to the liver, spleen, brain, and adrenal glands.
  • Fluorodeoxyglucose (FDG) positron emission tomography was performed to search for the primary site of malignancy, and lobulated FDG hypermetabolic lesions in the anterior mediastinum were found.
  • The diagnosis of thymic carcinoma with liver metastasis was then confirmed after morphological and immunohistochemical studies of hepatic and mediastinal biopsy specimens.

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  • (PMID = 19666356.001).
  • [ISSN] 0929-6646
  • [Journal-full-title] Journal of the Formosan Medical Association = Taiwan yi zhi
  • [ISO-abbreviation] J. Formos. Med. Assoc.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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5. Ikeda J, Morii E, Tomita Y, Zhang B, Tokunaga T, Inoue M, Minami M, Okumura M, Aozasa K: Mediastinal lymphangiomatosis coexisting with occult thymic carcinoma. Virchows Arch; 2007 Feb;450(2):211-4
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  • [Title] Mediastinal lymphangiomatosis coexisting with occult thymic carcinoma.
  • Mediastinal lymphangiomatosis in a 70-year-old woman was diagnosed on a medical checkup.
  • The patient continued on a downhill course and died approximately 3 years after the initial diagnosis.
  • Autopsy revealed a large tumor mass occupying the anterior mediastinum and firmly adhered to the pericardium and the pleura.
  • The former was diagnosed as lymphangiomatosis and the latter as thymic squamous cell carcinoma.
  • Vascular endothelial growth factor (VEGF)-C, a growth factor for lymphatic endothelial cells, was expressed by the carcinoma, and VEGF-C receptor was expressed by the endothelium of lymphangiomatosis.
  • These findings suggested that VEGF-C derived from the thymic carcinoma induced the lymphangiomatosis lesion in a paracrine manner.
  • [MeSH-major] Lymphangioma / pathology. Mediastinal Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Thymus Neoplasms / pathology

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  • (PMID = 17120029.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Vascular Endothelial Growth Factor C
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6. Steger CM, Morresi-Hauf A, Krugmann J, Schirmacher P, Rieker RJ, Mechtersheimer G: Two malignant tumours in the anterior mediastinum positive for CD5. BMJ Case Rep; 2010;2010
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  • [Title] Two malignant tumours in the anterior mediastinum positive for CD5.
  • To our knowledge, the simultaneous involvement of the anterior mediastinum by a thymic carcinoma and a B-cell chronic lymphocytic leukaemia has not been reported previously.
  • Chest x-ray and CT scan showed a mediastinal tumour, resected short-time after diagnosis.
  • First, standard based histological examination revealed a thymic carcinoma admixed by a dense lymphatic infiltrate.
  • Additional immunohistochemical staining for CD5-labelled epithelial thymic carcinoma cells as well as neoplastic B cells and led in combination with blood tests to confirm the diagnosis of the composite occurrence of a thymic carcinoma and a B-cell chronic lymphocytic leukaemia.
  • [MeSH-major] Antigens, CD5 / analysis. Leukemia, Lymphocytic, Chronic, B-Cell / diagnosis. Mediastinal Neoplasms / diagnosis. Thymoma / diagnosis. Thymus Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Humans. Immunohistochemistry. Male. Middle Aged. Radiography, Thoracic. Tomography, X-Ray Computed

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  • (PMID = 22752456.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD5
  • [Other-IDs] NLM/ PMC3034205
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7. Pinto Filho DR, Avino AJ, Brandão SL, Spiandorello WP: Joint use of cervical mediastinoscopy and video-assisted thoracoscopy for the evaluation of mediastinal lymph nodes in patients with non-small cell lung cancer. J Bras Pneumol; 2009 Nov;35(11):1068-74
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Joint use of cervical mediastinoscopy and video-assisted thoracoscopy for the evaluation of mediastinal lymph nodes in patients with non-small cell lung cancer.
  • OBJECTIVE: To evaluate the efficacy of the joint use of cervical mediastinoscopy and video-assisted thoracoscopy for the sampling of mediastinal lymph nodes in patients with non-small cell lung cancer (NSCLC) and candidates for pulmonary resection.
  • The samples obtained (from paratracheal chains, anterior and posterior subcarinal chains, paraesophageal chains and pulmonary ligament) were submitted to frozen section analysis.
  • In 60% of the patients with involvement of the posterior subcarinal chain, the primary tumor was in the right inferior lobe. (p = 0.029) CONCLUSIONS: The joint use of cervical mediastinoscopy and video-assisted thoracoscopy for the evaluation of posterior mediastinal lymph nodes proved to be an efficacious method.
  • When there is no access to posterior chains by means of ultrasound with transbronchial or transesophageal biopsy, which dispenses with general anesthesia, this should be the method of choice for the correct evaluation of mediastinal lymph nodes in patients with NSCLC.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / pathology. Lung Neoplasms / pathology. Lymph Nodes / pathology. Mediastinoscopy / methods. Thoracoscopy / methods
  • [MeSH-minor] Aged. Aged, 80 and over. Epidemiologic Methods. Female. Humans. Male. Mediastinum. Middle Aged

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  • (PMID = 20011841.001).
  • [ISSN] 1806-3756
  • [Journal-full-title] Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia
  • [ISO-abbreviation] J Bras Pneumol
  • [Language] eng; por
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Brazil
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8. Gannon BR, O'Hara CD, Reid K, Isotalo PA: Solitary fibrous tumor of the anterior mediastinum: a rare extrapleural neoplasm. Tumori; 2007 Sep-Oct;93(5):508-10

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Solitary fibrous tumor of the anterior mediastinum: a rare extrapleural neoplasm.
  • We describe a 62-year-old woman who presented with stridor and an anterior mediastinal mass.
  • At thoracotomy, a 10.5 x 6.5 x 5.5 cm, circumscribed, firm mediastinal mass demonstrated no direct cardiac or pulmonary involvement.
  • Spindle cells were immunoreactive for CD34, CD99, desmin, vimentin and bcl-2 protein and a diagnosis of mediastinal solitary fibrous tumor was confirmed.
  • The differential diagnosis of mediastinal solitary fibrous tumors is extensive and includes spindle cell thymoma, sarcomatoid carcinoma, malignant mesothelioma, inflammatory myofibroblastic tumor, peripheral nerve sheath tumors and various sarcomas.
  • Despite their rarity in the mediastinum, solitary fibrous tumors can be recognized by their classic patternless morphology and immunophenotypic pattern.
  • [MeSH-major] Mediastinal Neoplasms / pathology. Solitary Fibrous Tumors / pathology
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Immunoenzyme Techniques. Middle Aged

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  • (PMID = 18038888.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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9. Conti M, Benhamed L, Mortuaire G, Chevalier D, Pinçon C, Wurtz A: Indications and results of anterior mediastinal tracheostomy for malignancies. Ann Thorac Surg; 2010 May;89(5):1588-95
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  • [Title] Indications and results of anterior mediastinal tracheostomy for malignancies.
  • BACKGROUND: This study was designed to assess the early and long-term results, and determine suitable indications of anterior mediastinal tracheostomy, after radical resection for cervicothoracic malignancies.
  • METHODS: From 1985 to 2009, 13 patients ranging in age from 40 to 75 years underwent an anterior mediastinal tracheostomy for malignancy, 2 as an isolated procedure, 5 with concomitant laryngectomy, and 6 with concomitant laryngopharyngoesophagectomy.
  • The patients had subglottic carcinoma, proximal tracheal carcinoma invading the subglottic larynx (n = 6), stomal recurrence following laryngectomy (n = 4), esophageal carcinoma invading the proximal trachea (n = 2), or tracheal recurrence after conventional resection (n = 1).
  • Satisfactory airway was achieved in 7 patients presenting with proximal obstruction, and ability to tolerate oral feeding, in 2 patients with esophageal carcinoma.
  • Patients with esophageal carcinoma or recurrence of tracheal carcinoma showed a poor outcome.
  • CONCLUSIONS: Our results and survival analysis from the literature suggest that suitable indications for anterior mediastinal tracheostomy are (1) carcinoma of the subglottic region or proximal trachea invading the subglottic larynx, (2) stomal recurrence after laryngectomy, and (3) well-differentiated thyroid carcinoma invading the trachea or recurrence.
  • [MeSH-minor] Adult. Aged. Cause of Death. Cohort Studies. Esophagectomy / methods. Female. Follow-Up Studies. Hospital Mortality / trends. Humans. Laryngectomy / methods. Male. Mediastinum / surgery. Middle Aged. Patient Selection. Postoperative Complications / mortality. Postoperative Complications / physiopathology. Reconstructive Surgical Procedures / methods. Reconstructive Surgical Procedures / mortality. Retrospective Studies. Risk Assessment. Survival Analysis. Time Factors. Treatment Outcome

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  • [Copyright] Copyright (c) 2010 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.
  • [CommentIn] Ann Thorac Surg. 2010 May;89(5):1595-6 [20417784.001]
  • (PMID = 20417783.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Netherlands
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10. Oura H, Handa M, Sawada T, Watanabe Y, Tomichi N: [Median approach for upper lobe lung cancer patients with suspected anterior mediastinal invasion]. Kyobu Geka; 2008 May;61(5):363-6
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  • [Title] [Median approach for upper lobe lung cancer patients with suspected anterior mediastinal invasion].
  • We report the usefulness of a median approach to the mediastinum for the treatment of lung cancer with possible mediastinal invasion.
  • Patient was a 74-year-old man with left S3 squamous cell carcinoma suspected of anterior mediastinal invasion (cT4N0M0) because of hoarseness before surgery.
  • The tumor was widely adherent to the anterior mediastinum, invading the common carotid artery and the origin of the left subclavian artery.
  • For upper lobe lung cancer with possible mediastinal invasion, a median approach seems to be useful, because it facilitates both easy approach to the anterior mediastinum and the management of invasion of large vessels.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Lung Neoplasms / surgery. Mediastinal Neoplasms / pathology. Mediastinal Neoplasms / surgery. Pneumonectomy / methods

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  • (PMID = 18464479.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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11. Tomiyama N, Honda O, Tsubamoto M, Inoue A, Sumikawa H, Kuriyama K, Kusumoto M, Johkoh T, Nakamura H: Anterior mediastinal tumors: diagnostic accuracy of CT and MRI. Eur J Radiol; 2009 Feb;69(2):280-8
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  • [Title] Anterior mediastinal tumors: diagnostic accuracy of CT and MRI.
  • PURPOSE: To compare the diagnostic accuracy for anterior mediastinal tumors among CT, MRI, and both CT and MRI, and to determine the optimal CT and MRI procedures for the diagnosis of anterior mediastinal tumors.
  • MATERIALS AND METHODS: Both CT and MRI were performed in 127 patients with pathologically diagnosed anterior mediastinal tumors.
  • The patients included 48 cases of thymoma, 12 cases of thymic carcinoma, 12 cases of thymic cyst, 20 cases of mature teratoma, 13 cases of malignant germ cell tumor, and 22 cases of malignant lymphoma.
  • The observers recorded various CT and MRI findings and their first choice of diagnosis.
  • RESULTS: The two observers made a correct first-choice diagnosis in an average of 78 (61%) of 127 cases on CT, 71 (56%) of 127 cases on MRI, and 85.5 (67%) of 127 cases on both CT and MRI.
  • These included 83% cases of thymoma on CT, 84% on MRI, and 85% on both CT and MRI; 38% cases of thymic carcinoma on CT and 13% on MRI, and 33% on both CT and MRI; 46% cases of thymic cyst on CT and 71% on MRI, and 63% on both CT and MRI; 58% cases of mature teratoma and 38% on MRI, and 78% on both CT and MRI; 35% cases of malignant germ cell tumor on CT and 27% on MRI, and 31% on both CT and MRI; and 55% cases of malignant lymphoma on CT and 43% on MRI, and 61% on both CT and MRI.
  • There were significant differences between the diagnostic accuracy by CT and MRI in the cases with both thymic cysts and thymic carcinoma (p<0.05).
  • CONCLUSION: CT is equal or superior to MRI in the diagnosis of anterior mediastinal tumors except for thymic cyst.
  • CT should be considered the modality of choice following chest radiography, however, in certain circumstances, such as thymic cyst with hemorrhage or inflammation which mimic solid tumor despite low enhancement, MRI may be better in distinguishing anterior mediastinal tumors.
  • For more helpful information in the diagnosis of mature teratoma after CT, MRI may follow.
  • [MeSH-major] Magnetic Resonance Imaging / methods. Mediastinal Neoplasms / diagnosis. Tomography, X-Ray Computed / methods

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  • (PMID = 18023547.001).
  • [ISSN] 1872-7727
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Ireland
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12. Chen KN, Xu SF, Gu ZD, Zhang WM, Pan H, Su WZ, Li JY, Xu GW: Surgical treatment of complex malignant anterior mediastinal tumors invading the superior vena cava. World J Surg; 2006 Feb;30(2):162-70

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  • [Title] Surgical treatment of complex malignant anterior mediastinal tumors invading the superior vena cava.
  • Determining the appropriate surgery-based treatment for complicated anterior mediastinal malignancies (CAMM), especially those invading the superior vena cava (SVC) and its branches, remains a challenge for general thoracic surgeons.
  • In this report, we summarize our experience and lessons regarding this issue in order to discuss a reasonable strategy for diagnosis and treatment of CAMM.
  • Thymic carcinoma, teratoma, embryonal carcinoma, Hodgkin's lymphoma, non-Hodgkin's lymphoma, and mixed teratoma with thymoma were diagnosed in 1 patient each.
  • CAMM can be safely and completely resected via a median sternotomy, even if it has invaded other mediastinal structures.
  • A good outcome for patients with CAMM is possible if a suitable strategy combining accurate diagnosis and appropriate treatment, especially surgical resection, is established.
  • [MeSH-major] Mediastinal Neoplasms / pathology. Mediastinal Neoplasms / surgery. Neoplasm Invasiveness / pathology. Thoracotomy / methods. Vena Cava, Superior / pathology

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  • (PMID = 16425072.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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13. Okuda M, Yokomise H, Chang SS, Nakano J, Misaki N: Mediastinal metastasis of the thyroid papillary carcinoma mimicking thymoma. Gen Thorac Cardiovasc Surg; 2008 Oct;56(10):518-20
MedlinePlus Health Information. consumer health - Thyroid Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mediastinal metastasis of the thyroid papillary carcinoma mimicking thymoma.
  • Mediastinal tumors are a common condition encountered by general thoracic surgeons, and the most frequent of such tumors is thymoma.
  • However, metastatic mediastinal tumors are rare.
  • Here we report a case of papillary carcinoma of the thyroid to the mediastinum that mimicked thymoma.
  • The patient, a 60-year-old woman who had been treated for thyroid cancer 6 years previously, visited our hospital because of an abnormal shadow in the anterior mediastinum.
  • Radiological findings and laboratory data did not suggest any recurrence of the thyroid cancer, but computed tomography examination revealed a thymoma-like mass. (18)F-Fluoro-2-deoxy-D: -glucose positron emission tomography revealed two lesions: an anterior mediastinal mass and a right breast nodule.
  • Histological examination revealed that the mediastinal mass was a metastasis from the thyroid papillary carcinoma, whereas the nodule was an early breast cancer.
  • [MeSH-major] Carcinoma, Papillary / pathology. Mediastinal Neoplasms / secondary. Thymoma / pathology. Thyroid Neoplasms / pathology
  • [MeSH-minor] Breast Neoplasms / pathology. Breast Neoplasms / surgery. Carcinoma, Ductal, Breast / pathology. Carcinoma, Ductal, Breast / surgery. Diagnosis, Differential. Female. Humans. Mastectomy. Middle Aged. Positron-Emission Tomography. Thymectomy. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 18854931.001).
  • [ISSN] 1863-6705
  • [Journal-full-title] General thoracic and cardiovascular surgery
  • [ISO-abbreviation] Gen Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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14. Nakayama K, Okada D, Koizumi K, Kawaguchi Y, Shimizu K: [Tuberculoma of the mediastinal lymph nodes with spinal caries]. Kyobu Geka; 2006 Aug;59(9):826-30

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Tuberculoma of the mediastinal lymph nodes with spinal caries].
  • Chest computed tomography (CT) demonstrated partially calcified enlargements of the anterior mediastinal lymph nodes and pleural effusion in both lungs.
  • We could not determine whether the lesion was an invasion of the spinal cord by a carcinoma of unknown primary or malignant lymphomas.
  • Therefore, we performed a lymph node biopsy using a thoracoscope for a definitive diagnosis.
  • [MeSH-major] Lymph Nodes. Tuberculoma / diagnosis. Tuberculosis, Lymph Node / diagnosis. Tuberculosis, Spinal / complications
  • [MeSH-minor] Aged. Humans. Male. Mediastinum

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  • (PMID = 16922442.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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15. Motoyama S, Saito R, Okuyama M, Maruyama K, Nanjo H, Ogawa J: Long-term survival after salvage resection of recurrent esophageal cancer with anterior mediastinal lymph node involvement: report of a case. Surg Today; 2006;36(9):827-30
MedlinePlus Health Information. consumer health - Esophageal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-term survival after salvage resection of recurrent esophageal cancer with anterior mediastinal lymph node involvement: report of a case.
  • A 55-year-old man underwent subtotal esophagectomy with extended three-field lymph node dissection for squamous cell carcinoma of the middle thoracic esophagus (histological stage pT3N4(3b)M0, pStage IVa).
  • About 9 months later, contrast-enhanced computed tomography showed recurrence in several lymph nodes in the anterior mediastinum and the right side of the neck.
  • Although the indications for resection of recurrent esophageal cancer are controversial and we cannot generalize about the best treatment for these patients, this case highlights the possibility of using salvage surgical resection to treat recurrent esophageal cancer with anterior mediastinal lymph node involvement in selected patients.
  • [MeSH-major] Esophageal Neoplasms / surgery. Lymph Node Excision. Lymph Nodes / surgery. Mediastinal Neoplasms / surgery. Mediastinum / surgery. Neoplasm Recurrence, Local / surgery

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  • [Cites] J Am Coll Surg. 1996 Apr;182(4):340-6 [8605557.001]
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  • (PMID = 16937289.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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16. Dosios T, Kouskos E, Kyriakou V: Surgical management of mediastinal lesions. Tuberk Toraks; 2006;54(3):207-12

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical management of mediastinal lesions.
  • Mediastinal tumors and cysts are relatively uncommon lesions requiring histologic confirmation.
  • This retrospective study reports the experience of our department in the diagnosis and treatment of mediastinal lesions.
  • Mediastinal lesions that were surgically treated in 200 patients aged 6-84 years, during a period of 28 years, were included in this series.
  • Sixty patients had an apparently non-resectable lesion or lymphadenopathy of the anterior superior mediastinum.
  • They had an anterior mediastinotomy and biopsy of the mediastinal lesion.
  • Histological diagnosis was established in all patients: lymphoma (n = 21), metastatic carcinoma (n = 16), thymic lesions (n = 10), germ cell tumor (n = 3), other lesions (n = 10).
  • The remainder 140 patients underwent a resection of the mediastinal lesion.
  • The histological diagnosis of the excised lesions was: thymic lesions (n = 60), neural tumors (n = 21), thyroid lesions (n = 14), bronchial cysts (n = 12), pericardial cysts (n = 10), germ cell tumors (n = 6), other lesions (n = 17).
  • Surgery is the management of choice for patients with mediastinal lesions.
  • It allows for establishing certain histological diagnosis and curative excision of the lesion, when it is necessary, with low operative risk.
  • [MeSH-major] Mediastinal Diseases / epidemiology. Mediastinal Diseases / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Bronchogenic Cyst / diagnosis. Bronchogenic Cyst / epidemiology. Bronchogenic Cyst / etiology. Bronchogenic Cyst / pathology. Bronchogenic Cyst / radiography. Bronchogenic Cyst / surgery. Child. Female. Humans. Male. Mediastinal Cyst / diagnosis. Mediastinal Cyst / epidemiology. Mediastinal Cyst / etiology. Mediastinal Cyst / pathology. Mediastinal Cyst / radiography. Mediastinal Cyst / surgery. Mediastinal Neoplasms / diagnosis. Mediastinal Neoplasms / epidemiology. Mediastinal Neoplasms / etiology. Mediastinal Neoplasms / pathology. Mediastinal Neoplasms / radiography. Mediastinal Neoplasms / surgery. Medical Records. Middle Aged. Outcome Assessment (Health Care). Retrospective Studies. Thoracic Surgical Procedures / statistics & numerical data. Thymus Neoplasms / diagnosis. Thymus Neoplasms / epidemiology. Thymus Neoplasms / etiology. Thymus Neoplasms / pathology. Thymus Neoplasms / radiography. Thymus Neoplasms / surgery. Turkey / epidemiology

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  • (PMID = 17001536.001).
  • [ISSN] 0494-1373
  • [Journal-full-title] Tüberküloz ve toraks
  • [ISO-abbreviation] Tuberk Toraks
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Turkey
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17. Yoshino M, Mizobuchi T, Fujiwara T, Noro M, Akikusa B, Iwai N: Large mediastinal cyst of an ectopic thyroid with small nodules diagnosed as papillary carcinoma. Jpn J Thorac Cardiovasc Surg; 2006 Dec;54(12):550-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Large mediastinal cyst of an ectopic thyroid with small nodules diagnosed as papillary carcinoma.
  • A 49-year-old man was admitted to hospital for investigation of a mediastinal shadow seen on a chest radiograph.
  • Chest completed tomography revealed a mediastinal mass of 65 x 55mm.
  • At surgery, the mass was found to be contained within the upper mediastinum and adherent to the vertebrae, esophagus, trachea, and superior vena cava.
  • The lateral incision enabled detachment of the adhesion between the mass and the posterior to median mediastinum, and the modified transmanubrial approach was useful for separating the mass from the upper to anterior mediastinum.
  • Histological examination revealed a large mediastinal cyst of an ectopic thyroid with small nodules diagnosed as papillary carcinoma.
  • [MeSH-major] Carcinoma, Papillary / diagnosis. Choristoma. Mediastinal Cyst / diagnosis. Mediastinal Neoplasms / diagnosis. Thyroid Gland

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  • (PMID = 17236661.001).
  • [ISSN] 1344-4964
  • [Journal-full-title] The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai zasshi
  • [ISO-abbreviation] Jpn. J. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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18. Zannoni GF, Vellone VG, Distefano MG, Fadda G, Scambia G: Ovarian serous carcinoma presenting with mediastinal lymphadenopathy 20 months before the intraabdominal mass: role of immunohistochemistry. Gynecol Oncol; 2007 Feb;104(2):497-500
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ovarian serous carcinoma presenting with mediastinal lymphadenopathy 20 months before the intraabdominal mass: role of immunohistochemistry.
  • INTRODUCTION: Metastatic involvement of the mediastinal lymph nodes is an extremely uncommon finding in epithelial ovarian cancers.
  • CASE REPORT: A 63-year-old woman was admitted to hospital for dyspnoea due to an anterior mediastinal mass.
  • After 20 months a follow-up CT identified an ovarian mass with the same histological pattern and immunoreactivity of the mediastinal nodule.
  • [MeSH-major] Lymph Nodes / pathology. Lymphatic Diseases / diagnosis. Mediastinal Neoplasms / diagnosis. Ovarian Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Immunohistochemistry. Lymphatic Metastasis. Middle Aged


19. Masuda M, Wakasaki T, Tamae A, Komune N, Hara T, Uchiyama A: [Mediastinal dissection for patients with differentiated thyroid carcinoma: sternotomy vs VATS (video-assisted thoracoscopic surgery)]. Nihon Jibiinkoka Gakkai Kaiho; 2007 Dec;110(12):758-61
MedlinePlus Health Information. consumer health - Thyroid Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Mediastinal dissection for patients with differentiated thyroid carcinoma: sternotomy vs VATS (video-assisted thoracoscopic surgery)].
  • We here present two cases of differentiated thyroid carcinoma with mediastinal lymph nodes metastases below level 106 according to the classification of the Guidelines for the Clinical and Pathologic Studies for Carcinoma of the Esophagus (9 th edition) edited by the Japanese Society for Esophageal Diseases.
  • For Case 1, we adopted a conventional anterior approach with resection of the right half of the manubrium and sternum to the level of the second intercostal space and medial half of the right clavicule.
  • Conversely, in Case 2, in which mediastinal lymph nodes extended to level 107, the lymph nodes were relatively easily dissected by VATS under excellent surgical views of 106tbR and 107.
  • [MeSH-major] Lymph Node Excision / methods. Mediastinum / surgery. Sternum / surgery. Thoracic Surgery, Video-Assisted. Thyroid Neoplasms / surgery

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  • (PMID = 18186293.001).
  • [ISSN] 0030-6622
  • [Journal-full-title] Nihon Jibiinkoka Gakkai kaiho
  • [ISO-abbreviation] Nippon Jibiinkoka Gakkai Kaiho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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20. Nakajima T, Iizasa T, Iyoda A, Hiroshima K, Yasufuku K, Chiyo M, Anayama T, Suzuki H, Shibuya K, Ohwada H, Fujisawa T: Pleomorphic carcinoma of the lung with mediastinal extension following malignant lymphoma: report of a case. Surg Today; 2005;35(11):968-71
MedlinePlus Health Information. consumer health - Lung Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pleomorphic carcinoma of the lung with mediastinal extension following malignant lymphoma: report of a case.
  • In following up a patient with non-Hodgkin's lymphoma, we encountered a case of pulmonary pleomorphic carcinoma with mediastinal direct invasion.
  • A 6.4 x 4.8-cm tumor adjacent to the upper mediastinum occupied the right anterior segment of the upper lobe (S3) and invaded the superior vena cava (SVC).
  • The resected tumor was diagnosed as a pulmonary pleomorphic carcinoma with a large component of giant and spindle cells, and it is considered to be a rare histologic type.
  • [MeSH-major] Carcinoma / diagnosis. Carcinoma, Giant Cell / diagnosis. Lung Neoplasms / diagnosis. Lymphoma, Non-Hodgkin. Neoplasms, Second Primary. Vascular Neoplasms / pathology. Vascular Neoplasms / secondary. Vena Cava, Superior

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  • (PMID = 16249854.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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21. Horie M, Arai H, Noguchi S, Suzuki M, Sakamoto Y, Oka T: [Kartagener syndrome with lung cancer and mediastinal tumor]. Nihon Kokyuki Gakkai Zasshi; 2010 May;48(5):375-8
MedlinePlus Health Information. consumer health - Lung Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Kartagener syndrome with lung cancer and mediastinal tumor].
  • Chest computed tomography demonstrated a 5-cm mass in the anterior mediastinum as well as a 4-cm mass in the upper lobe of the right lung.
  • A transbronchial lung biopsy of the right lung tumor revealed squamous cell carcinoma.
  • Electron microscopic examination of the bronchial epithelial cilia revealed a total defect of both inner and outer dynein arms, leading to a diagnosis of primary ciliary dyskinesia.
  • Biopsy of the mediastinal tumor was not performed.
  • After concurrent chemoradiation therapy, the lung cancer decreased in size partial remission (PR) and the mediastinal tumor disappeared complete remission (CR).
  • He died 1 year after the diagnosis of lung cancer was established.
  • There have been 5 reported cases of Kartagener syndrome complicated with lung cancer, but to the best of our knowledge there have been no reports of Kartagener syndrome with mediastinal tumor.
  • [MeSH-major] Carcinoma, Squamous Cell / complications. Kartagener Syndrome / complications. Lung Neoplasms / complications. Mediastinal Neoplasms / complications

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  • (PMID = 20560440.001).
  • [ISSN] 1343-3490
  • [Journal-full-title] Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
  • [ISO-abbreviation] Nihon Kokyuki Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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22. Gallego J, Cruz J, Mendes S, Caldeira J, Nobre A, Cravino J: [Surgical diagnosis of mediastinal pathology: eleven-years experience]. Rev Port Cir Cardiotorac Vasc; 2005 Oct-Dec;12(4):215-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Surgical diagnosis of mediastinal pathology: eleven-years experience].
  • Between January 1993 and December 2004, 68 patients with mediastinal pathology were submitted to diagnosis surgery.
  • All the pathological process were located in the anterior mediastinum, and most of them were malignant (64.1%).
  • Seven cases consisted in ganglionar tuberculosis (10.3%), six cases were ganglionar metastases of lung adenocarcinoma (8.8%), and three cases were thymic carcinoma (4.4%).
  • One patient had no definite diagnosis (1.5%).
  • In this experience high diagnosis accuracy (98.5%), and low morbidity were demonstrated.
  • Although the present video assisted thoracic surgery progress and development, mediastinoscopy still remains as a reliable, safe and efficient surgical approach for the diagnosis of mediastinal pathology.
  • [MeSH-major] Mediastinal Diseases / diagnosis. Mediastinal Diseases / surgery

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  • (PMID = 16474861.001).
  • [ISSN] 0873-7215
  • [Journal-full-title] Revista portuguesa de cirurgia cardio-torácica e vascular : órgão oficial da Sociedade Portuguesa de Cirurgia Cardio-Torácica e Vascular
  • [ISO-abbreviation] Rev Port Cir Cardiotorac Vasc
  • [Language] por
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Portugal
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23. Demirag F, Cakir E, Aydin E, Kaya S, Akyurek N: Ectopic primary B cell lymphoma of the thyroid presenting as an anterior mediastinal mass. A case report. Acta Chir Belg; 2009 Nov-Dec;109(6):802-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ectopic primary B cell lymphoma of the thyroid presenting as an anterior mediastinal mass. A case report.
  • Ectopic thyroid tumours arising in the mediastinum without connection to the cervical thyroid gland are very rare.
  • Follicular adenoma, papillary carcinoma and follicular carcinoma in the mediastinum has been reported, but primary ectopic thyroid B cell lymphoma has not been reported previously.
  • We report mediastinal primary ectopic thyroid large B cell lymphoma in an 80-year-old man.
  • Differential diagnosis from primary mediastinal large B cell lymphoma and clinicopathologic features are discussed.
  • [MeSH-major] Choristoma / pathology. Lymphoma, B-Cell / diagnosis. Mediastinal Neoplasms / diagnosis. Thyroid Gland

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  • (PMID = 20184075.001).
  • [ISSN] 0001-5458
  • [Journal-full-title] Acta chirurgica Belgica
  • [ISO-abbreviation] Acta Chir. Belg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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24. St Hill S: Thymic carcinoma. Aviat Space Environ Med; 2007 Jan;78(1):67-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Thymic carcinoma.
  • This is a case of thymic carcinoma-a rare and highly aggressive type of tumor found in the anterior mediastinum.
  • During a routine chest X-ray, a 66-yr-old male pilot was found to have a mediastinal mass.
  • After diagnosis, he underwent chemotherapy, surgery, and radiation therapy and 1 yr after completion of these therapies he was re-issued a third-class medical certificate to fly.

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  • (PMID = 17225487.001).
  • [ISSN] 0095-6562
  • [Journal-full-title] Aviation, space, and environmental medicine
  • [ISO-abbreviation] Aviat Space Environ Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; BG3F62OND5 / Carboplatin; P88XT4IS4D / Paclitaxel
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25. Tsunoda Y, Tanaka K, Okada K, Ishizu H, Masuko H, Hata T, Kawamura H, Yokota R, Yamagami H, Watarai H, Yokota K, Tanioka T: [Thymic basaloid carcinoma]. Kyobu Geka; 2010 Sep;63(10):857-61
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  • [Title] [Thymic basaloid carcinoma].
  • This is a case of a 72-year-old male whose chest computed tomography (CT) revealed a 2.0 x 1.6 cm anterior mediastinal solid tumor during follow-up of an abnormal shadow of the lung.
  • Radical thymectomy was performed, and histopathologically the tumor was diagnosed as thymic basaloid carcinoma.
  • Thymic basaloid carcinoma is a rare tumor and is often associated with multilocular thymic cyst.
  • [MeSH-major] Carcinoma, Basal Cell / surgery. Thymus Neoplasms / surgery

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  • (PMID = 20845693.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
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26. Lanuti M, De Delva PE, Gaissert HA, Wright CD, Wain JC, Allan JS, Donahue DM, Mathisen DJ: Review of superior vena cava resection in the management of benign disease and pulmonary or mediastinal malignancies. Ann Thorac Surg; 2009 Aug;88(2):392-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Review of superior vena cava resection in the management of benign disease and pulmonary or mediastinal malignancies.
  • We analyzed the operative results, graft patency, and survival in patients undergoing SVC resection and reconstruction for benign disease and pulmonary or mediastinal malignancy.
  • Malignant disease was resected in 17: lung cancer in 9 and mediastinal malignancy in 8.
  • Five-year survival probability was 30% for patients with resected lung cancer and 56% for patients with resected anterior mediastinal malignancies.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / surgery. Lung Neoplasms / surgery. Mediastinal Neoplasms / surgery. Vena Cava, Superior / surgery

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  • [CommentIn] Ann Thorac Surg. 2009 Aug;88(2):397-8 [19632381.001]
  • (PMID = 19632380.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
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27. Orki A, Tezel C, Kosar A, Ersev AA, Dudu C, Arman B: Feasibility of imprint cytology for evaluation of mediastinal lymph nodes in lung cancer. Jpn J Clin Oncol; 2006 Feb;36(2):76-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Feasibility of imprint cytology for evaluation of mediastinal lymph nodes in lung cancer.
  • BACKGROUND: Intraoperative evaluation of mediastinal lymph nodes is a necessary step which helps us to decide whether or not to continue the operation of lung cancer.
  • Therefore, we compared the diagnostic accuracy of IC with permanent section on 1050 mediastinal lymph nodes.
  • In order to obtain lymph node samples mediastinoscopy was performed in 232 (91%), anterior mediastinotomy in 50 (20%) and video-assisted thoracoscopic surgery in 16 (6.3%) patients.
  • During final pathological diagnosis, both imprint and permanent section slides were compared.
  • CONCLUSIONS: The diagnostic IC is an accurate, reliable, simple and less time-consuming method for evaluation of mediastinal lymph nodes in lung cancer, compared with FS method.
  • [MeSH-major] Adenocarcinoma / diagnosis. Carcinoma, Non-Small-Cell Lung / diagnosis. Cytodiagnosis / methods. Lung Neoplasms / diagnosis. Lymph Nodes / pathology. Neoplasm Staging. Sentinel Lymph Node Biopsy / methods
  • [MeSH-minor] Adult. Aged. False Negative Reactions. False Positive Reactions. Feasibility Studies. Female. Frozen Sections / methods. Humans. Male. Mediastinum / pathology. Middle Aged. Prospective Studies. Sensitivity and Specificity. Time Factors

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  • (PMID = 16436461.001).
  • [ISSN] 0368-2811
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Japan
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28. Nar Demirer A, Ayturk S, Tutuncu NB, Gursoy A, Pak Y, Demirag NG: Unresectable huge sternal and mediastinal metastasis of follicular thyroid carcinoma; radiotherapy as first-line and palliative therapy. Exp Clin Endocrinol Diabetes; 2009 Apr;117(4):155-8
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  • [Title] Unresectable huge sternal and mediastinal metastasis of follicular thyroid carcinoma; radiotherapy as first-line and palliative therapy.
  • Distant metastases as initial manifestation of follicular thyroid carcinoma is rare.
  • We report a case of an unusual initial presentation of follicular thyroid carcinoma on follow-up.
  • A 52- year-old woman presented with a 12-month history of progressively enlarging mass in the anterior chest wall.
  • Computed tomography demonstrated a lobulated soft-tissue mass (17 x 11 x 6 cm) destructing sternum and extending into the anterior mediastinum.
  • Biopsy from this nodule and the sternal mass revealed typical histology of follicular carcinoma.
  • [MeSH-major] Adenocarcinoma, Follicular / radiotherapy. Mediastinal Neoplasms / radiotherapy. Thoracic Neoplasms / radiotherapy. Thyroid Neoplasms / radiotherapy

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  • (PMID = 18561094.001).
  • [ISSN] 1439-3646
  • [Journal-full-title] Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association
  • [ISO-abbreviation] Exp. Clin. Endocrinol. Diabetes
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Iodine Radioisotopes; 721M9407IY / Propylthiouracil; Q51BO43MG4 / Thyroxine
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29. Moran CA, Suster S, Silva EG: Low-grade serous carcinoma of the ovary metastatic to the anterior mediastinum simulating multilocular thymic cysts: a clinicopathologic and immunohistochemical study of 3 cases. Am J Surg Pathol; 2005 Apr;29(4):496-9
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  • [Title] Low-grade serous carcinoma of the ovary metastatic to the anterior mediastinum simulating multilocular thymic cysts: a clinicopathologic and immunohistochemical study of 3 cases.
  • Three cases of serous borderline tumors of the ovary with areas of serous low-grade carcinoma metastatic to the anterior mediastinum simulating multilocular thymic cysts are presented.
  • Follow-up radiologic examination revealed the presence of an anterior mediastinal tumor.
  • The 3 patients underwent surgical resection of the mediastinal tumor.
  • Grossly, the mediastinal tumors measured from 7 to 9 cm in greatest diameter and were described as cystic with solid areas.
  • Two patients remain alive and well after follow-up ranging from 6 to 18 months and 1 patient died of tumor 18 years after initial diagnosis.
  • [MeSH-major] Cystadenocarcinoma, Serous / secondary. Mediastinal Cyst / pathology. Mediastinal Neoplasms / secondary. Mediastinum / pathology. Ovarian Neoplasms / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Keratins / analysis. Middle Aged

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  • (PMID = 15767804.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 68238-35-7 / Keratins
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30. Isowa N, Kikuchi R, Kunimoto Y, Ito K, Tokuyasu H, Fukuda K, Kawasaki Y: Successful resection of posterior mediastinal thyroid cancer by partial sternotomy combined with video-assisted thoracoscopy. Ann Thorac Cardiovasc Surg; 2007 Feb;13(1):47-9
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  • [Title] Successful resection of posterior mediastinal thyroid cancer by partial sternotomy combined with video-assisted thoracoscopy.
  • We report on a rare case of substernal thyroid carcinoma extending into the posterior mediastinum of a 48-year-old man.
  • The tumor was resected by partial sternotomy and a small anterior thoracotomy, combined with video-assisted thoracoscopy.
  • The pathological diagnosis was of a well differentiated papillary adenocarcinoma of the thyroid with mediastinal extension.
  • We describe this surgical approach and discuss the advantage for cervicothoracic tumors extending into the posterior mediastinum.
  • [MeSH-major] Adenocarcinoma, Papillary / surgery. Mediastinal Neoplasms / surgery. Thoracic Surgery, Video-Assisted. Thoracotomy / methods. Thyroid Neoplasms / surgery

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  • (PMID = 17392672.001).
  • [ISSN] 1341-1098
  • [Journal-full-title] Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia
  • [ISO-abbreviation] Ann Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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31. Nechala P, Graham AJ, McFadden SD, Grondin SC, Gelfand G: Retrospective analysis of the clinical performance of anterior mediastinotomy. Ann Thorac Surg; 2006 Dec;82(6):2004-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Retrospective analysis of the clinical performance of anterior mediastinotomy.
  • This study examined the clinical performance of anterior mediastinotomy in staging patients with suspected left upper lobe non-small cell lung cancer.
  • After exclusions, 151 patients were stratified into two groups: 117 patients had cervical and anterior mediastinotomy as part of preoperative staging, and 34 had cervical mediastinoscopy only.
  • The primary outcome was rate of preventable thoracotomy defined as thoracotomy during which either metastases to aortopulmonary or paraaortic lymph nodes, or mediastinal invasion was identified.
  • RESULTS: The rate of preventable thoracotomy for the anterior mediastinotomy arm was 4 (3.4%) of 117, compared with 1 (2.9%) of 34 for cervical mediastinoscopy-only arm (p = 0.99).
  • The rate of morbidity in the anterior mediastinotomy arm was 8 (6.8%) of 117, compared with 2 (5.8%) of 34 for the cervical mediastinoscopy-only arm (p = 0.99).
  • Anterior mediastinotomy patients stayed in hospital 1 day longer (p = 0.008).
  • Anterior mediastinotomy was successful at harvesting one or more lymph nodes in 67% of patients.
  • Five patients (4.3%) who underwent anterior mediastinotomy were spared a thoracotomy by identification of metastases to aortopulmonary lymph nodes.
  • CONCLUSIONS: In patients with suspected left upper lobe lung cancer and otherwise normal computed tomography scan results, anterior mediastinotomy does not significantly reduce the rate of preventable thoracotomy.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / pathology. Lung Neoplasms / pathology. Mediastinum / surgery. Thoracotomy / methods

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  • (PMID = 17126099.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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32. Kobayashi N, Koizumi T, Eguchi T, Hyogotani A, Saito G, Hamanaka K, Shiina T, Kurai M, Kondo R, Yoshida K, Amano J: A mediastinal somatic-type germ cell tumor with hepatic metastasis successfully treated by multiple modalities. Anticancer Res; 2010 Dec;30(12):5117-20
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  • [Title] A mediastinal somatic-type germ cell tumor with hepatic metastasis successfully treated by multiple modalities.
  • Rhabdomyosarcoma in the mediastinum coexisting with metastatic non-seminomatous germ cell tumor, so-called somatic-type malignancy, is a rare carcinoma and has poor survival.
  • This study reports a case of diffuse and huge hepatic metastasis of non-seminomatous germ cell tumor associated with coexisting embryonal rhabdomyosarcoma in the mediastinum.
  • Concomitantly, an anterior mediastinal mass was found on chest CT.
  • The remaining mediastinal tumor was completely and successfully resected.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Choriocarcinoma / drug therapy. Liver Neoplasms / drug therapy. Liver Neoplasms / secondary. Mediastinal Neoplasms / drug therapy. Rhabdomyosarcoma, Embryonal / drug therapy. Teratoma / drug therapy

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  • (PMID = 21187499.001).
  • [ISSN] 1791-7530
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin
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33. Song SY, Ko YH, Ahn G: Mediastinal germ cell tumor associated with histiocytic sarcoma of spleen: case report of an unusual association. Int J Surg Pathol; 2005 Jul;13(3):299-303
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  • [Title] Mediastinal germ cell tumor associated with histiocytic sarcoma of spleen: case report of an unusual association.
  • We present an unusual association of mediastinal germ cell tumor containing seminoma and angiosarcoma components and splenic histiocytic sarcoma.
  • Histopathologically, an anterior mediastinal mass contained typical seminoma, immature teratoma, embryonal carcinoma, angiosarcoma, yolk sac tumor, and polyembryoma.
  • [MeSH-major] Hemangiosarcoma / pathology. Histiocytic Sarcoma / pathology. Mediastinal Neoplasms / pathology. Seminoma / pathology. Splenic Neoplasms / pathology

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  • (PMID = 16086090.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin; BEP protocol
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34. Tinica G, Butcovan D, Cimpeanu C, Târcoveanu E: A mediastinal germ cell tumor of yolk sac type--case report. Chirurgia (Bucur); 2010 Nov-Dec;105(6):831-4
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  • [Title] A mediastinal germ cell tumor of yolk sac type--case report.
  • OBJECTIVE: We report an extremely rare case of germ-cell tumor localized at the level of the anterior mediastinum.
  • Computed tomographic scan of the chest showed a large anterior mediastinal mass.
  • Surgical intervention revealed an infiltrative mediastinal tumor involving the left subclavial vein, which was biopsied for morphological examination.
  • Histologically, the tumoral mass proved to be a carcinoma, with papillary and tubular growth patterns.
  • This supported the diagnosis of Yolk sac tumor, a rare primary tumor within the mediastinum.
  • CONCLUSION: Primary mediastinal Yolk sac neoplasm is a rare tumor.
  • The diagnosis should be made not only by morphological studies but also the patient's age and the elevation of serum alpha-fetoprotein.
  • In spite of modern chemotherapy, the prognosis of mediastinal yolk sac tumor remains poor.
  • [MeSH-major] Endodermal Sinus Tumor. Mediastinal Neoplasms
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / blood. Biopsy. Bleomycin / administration & dosage. Carcinoma / diagnosis. Cisplatin / administration & dosage. Diagnosis, Differential. Etoposide / administration & dosage. Humans. Male. Prognosis. alpha-Fetoproteins / metabolism

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  • (PMID = 21351701.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / alpha-Fetoproteins; 11056-06-7 / Bleomycin; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin
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35. Nakahira M, Nakatani H, Takeuchi S, Higashiyama K, Fukushima K: Safe reconstruction of a large cervico-mediastinal tracheal defect with a pectoralis major myocutaneous flap and free costal cartilage grafts. Auris Nasus Larynx; 2006 Jun;33(2):203-6
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  • [Title] Safe reconstruction of a large cervico-mediastinal tracheal defect with a pectoralis major myocutaneous flap and free costal cartilage grafts.
  • A large cervico-mediastinal tracheal defect in a 72-year-old man as a result of surgery for thyroid carcinoma with tracheal invasion and mediastinal lymph node metastasis was reconstructed using a pectoralis major myocutaneous flap and free costal cartilage grafts.
  • The tracheal defect (55 mm x 30 mm) was located at the thoracic inlet adjacent to the major mediastinal vessels.
  • Two pieces of free costal cartilage were grafted on the pectoralis major myocutaneous flap, one for the lateral wall reconstruction and the other prefabricated for the anterior wall of the trachea.
  • In the second stage, the re-vascularized cartilage graft for the anterior wall of the trachea with overlying skin was rotated onto the trough of the remaining trachea and the closure of the tracheal defect was completed.
  • We conclude that free cartilage grafts for the reconstruction of a large cervico-mediastinal tracheal defect can be safely used when they are combined with well-vascularized pectoralis major myocutaneous flaps.
  • [MeSH-minor] Aged. Humans. Male. Mediastinum. Neck. Ribs / surgery. Thyroid Neoplasms / surgery. Transplantation, Autologous

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  • (PMID = 16289423.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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36. Zhang SY, Wang X, Rong TH, Zheng L, Zeng CG, Xie ZM, Yu H, Zhu ZH: [Evaluation of lymph node metastasis in the contralateral mediastinum or scalene through mediastinoscopy and para-mediastinal small incision in potentially operable non-small cell lung cancer]. Zhonghua Zhong Liu Za Zhi; 2007 Aug;29(8):629-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Evaluation of lymph node metastasis in the contralateral mediastinum or scalene through mediastinoscopy and para-mediastinal small incision in potentially operable non-small cell lung cancer].
  • OBJECTIVE: The purpose of this study was to investigate the clinical characteristics of lymph node metastasis in the contralateral mediastinum and scalene in patients with potentially operable nonsmall cell lung cancer (NSCLC).
  • Of these, 12 underwent cervical medistinoscopy combined with right scalene lymph node biopsy and 10 with anterior para-mediastinal small incision.
  • RESULTS: A total of 9 patients were found have N3 disease on mediastinosopy, with cancer-cell-positive lymph nodes in the contralateral mediastinum in 6 and 3 in the right scalene.
  • Statistical analysis revealed that the incidence of N3 disease in adenocarcinoma group was higher than that in patients with nonadenocarcinoma (P < 0.05), which was also higher in the patients with serum CEA >5 ng/ml than that in the patients with CEA <5 ng/ml (P < 0.05), and it was higher in the patients with ipsilateral mediastinal multi-station lymph node metastasis than that in the patients with uni-station lymph node metastasis (P < 0.05).
  • CONCLUSION: Biopsy of contralateral mediastinal lymph nodes or scalene lymph node should be performed in order to exclude N3 disease for potentially operable NSCLC patients with adenocarcinoma, serum CEA >5 ng/ml or ipsilateral multi-station mediastinal lymph node metastasis.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / pathology. Lung Neoplasms / pathology. Lymph Nodes / pathology. Mediastinoscopy
  • [MeSH-minor] Adenocarcinoma / blood. Adenocarcinoma / pathology. Adenocarcinoma / therapy. Adult. Aged. Biopsy. Carcinoembryonic Antigen / blood. Carcinoma, Squamous Cell / blood. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / therapy. Chemotherapy, Adjuvant. Female. Humans. Lymph Node Excision. Lymphatic Metastasis. Male. Mediastinum. Middle Aged. Neck Muscles. Neoplasm Staging. Pneumonectomy

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  • (PMID = 18210888.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen
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37. Ceyhan K, Utkan G, Dincol D, Erdogan N, Erekul S, Umudum H: Fine needle aspiration biopsy features with histologic correlation in mediastinal hepatoid yolk sac tumor presenting with sternum metastasis: a case report. Acta Cytol; 2007 Jul-Aug;51(4):610-5
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  • [Title] Fine needle aspiration biopsy features with histologic correlation in mediastinal hepatoid yolk sac tumor presenting with sternum metastasis: a case report.
  • We present and discuss our experience with cytologic and histopathologic features of a mediastinal H-YST presenting with sternum metastasis, which to the best of our knowledge has not been previously reported.
  • Computed tomography of the thorax showed a large anterior mediastinal mass with sternum metastsis and multiple lung metastases.
  • Cytologically, the tumor was composed of monotonous, large, round to polygonal hepatoid cells forming solid sheets and trabeculae entrapped with endothelial cells resembling hepatocellular carcinoma.
  • CONCLUSION: Fine needle aspiration cytology, together with the characteristic clinical presentations and specific tumor markers, is crucial to the initial diagnosis of H-YST.
  • [MeSH-major] Endodermal Sinus Tumor / pathology. Mediastinal Neoplasms / pathology. Sternum / pathology

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  • (PMID = 17718136.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies; 0 / alpha-Fetoproteins
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38. Savitt MA, Gao G, Furnary AP, Swanson J, Gately HL, Handy JR: Application of robotic-assisted techniques to the surgical evaluation and treatment of the anterior mediastinum. Ann Thorac Surg; 2005 Feb;79(2):450-5; discussion 455
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  • [Title] Application of robotic-assisted techniques to the surgical evaluation and treatment of the anterior mediastinum.
  • BACKGROUND: We report our initial experience with the application of robotic-assisted technologies to the treatment of diseases of the anterior mediastinum.
  • METHODS: Between October 2001 and December 2003, 18 consecutive patients with anterior mediastinal masses were referred for diagnosis and treatment.
  • One patient underwent robotic-assisted biopsy of a mass that was later determined to be a poorly differentiated carcinoma, 3 patients underwent complete thymectomy by median sternotomy for biopsy-proven extracapsular thymoma, 7 patients had thymoma, and 3 had myasthenia gravis.
  • Primary thymic carcinoid, thymolipoma, papillary thyroid cancer, and poorly differentiated carcinoma were present in 1 patient each.
  • CONCLUSIONS: Robotic-assisted surgery of the anterior mediastinum, and particularly thymectomy, can be performed safely and efficiently.
  • The increased visualization and instrument dexterity afforded by this technology provides an optimal minimally invasive approach to the anterior mediastinum.
  • From this experience we have formulated a comprehensive treatment algorithm for the surgical evaluation and treatment of patients with anterior mediastinal diseases.
  • [MeSH-major] Biopsy / methods. Mediastinal Diseases / diagnosis. Mediastinal Diseases / surgery. Robotics / methods. Thymectomy / methods. Thymus Neoplasms / diagnosis. Thymus Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. Humans. Length of Stay. Male. Middle Aged. Myasthenia Gravis / diagnosis. Myasthenia Gravis / surgery. Thymoma / diagnosis. Thymoma / pathology. Thymoma / surgery. Thyroid Neoplasms / diagnosis. Thyroid Neoplasms / pathology. Thyroid Neoplasms / surgery. Treatment Outcome

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  • (PMID = 15680812.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Netherlands
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39. Yaris N, Nas Y, Cobanoglu U, Yavuz MN: Thymic carcinoma in children. Pediatr Blood Cancer; 2006 Aug;47(2):224-7
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  • [Title] Thymic carcinoma in children.
  • Thymic carcinoma rarely occurs in children.
  • Here we have reported a 16-year old girl who presented with respiratory distress due to huge anterior mediastinal mass.
  • Histological and immunohistochemical studies confirmed lymphoepithelioma-like thymic carcinoma.

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  • (PMID = 16007580.001).
  • [ISSN] 1545-5009
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 23
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40. Iwata T, Inoue K, Mizuguchi S, Morita R, Tsukioka T, Suehiro S: Thymic small cell carcinoma associated with pulmonary squamous cell carcinoma. Ann Thorac Surg; 2006 Dec;82(6):2266-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Thymic small cell carcinoma associated with pulmonary squamous cell carcinoma.
  • Chest computed tomography showed an anterior mediastinal mass and a lung mass in the right lower lobe.
  • Thallium scintigraphy revealed accumulation in the mediastinal mass.
  • Therefore, under diagnosis of invasive thymoma or thymic carcinoma associated with suspected lung cancer, exploratory right thoracotomy was undertaken through a median sternotomy with video-assisted thoracoscopic support.
  • The lung mass was intraoperatively diagnosed as squamous cell carcinoma.
  • Thymic small cell carcinoma was diagnosed; therefore the patient received 50 Gy of irradiation to the mediastinum.
  • [MeSH-major] Carcinoma, Small Cell / therapy. Carcinoma, Squamous Cell / surgery. Lung Neoplasms / surgery. Neoplasms, Multiple Primary. Thymus Neoplasms / therapy

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  • (PMID = 17126147.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
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41. Usami N, Fukui T, Ito S, Sato N, Uchiyama M, Taniguchi T, Yoshioka H, Yokoi K: [Pulmonary pleomorphic carcinoma; report of a case]. Kyobu Geka; 2005 Oct;58(11):1013-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Pulmonary pleomorphic carcinoma; report of a case].
  • We report a case of a 64-year-old man with pleomorphic carcinoma of the lung and thymic cyst.
  • Computed tomography (CT) showed a mass lesion located in the right upper lobe and a non-invasive anterior mediastinal tumor adjacent to the left brachiocepharic vein.
  • With a diagnosis of primary lung cancer (cT3N0M0) and mediastinal tumor, an operation was performed through a median sternotomy.
  • The mediastinal tumor was excised and a right upper lobectomy and were also accomplished, because the lung tumor did not show adhesion or pleural invasion.
  • Histopathologic examination of the resected specimen revealed that the lung tumor composed of a mixture of spindle and giant cell features and contained a component of adenocarcinoma and squamous cell carcinoma.
  • This finding yielded a pathological diagnosis of pleomorphic carcinoma (pT2N0M0).
  • The mediastinal tumor was diagnosed as thymic cyst.
  • [MeSH-major] Adenocarcinoma / pathology. Carcinoma, Squamous Cell / pathology. Lung Neoplasms / pathology. Pneumonectomy
  • [MeSH-minor] Humans. Male. Mediastinal Cyst / complications. Middle Aged. Neoplasms, Multiple Primary

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  • (PMID = 16235854.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 9
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42. Munakata W, Ohashi K, Sakaguchi K, Horio H, Hishima T, Akiyama H, Sakamaki H: Erythrocytosis caused by erythropoietin-producing thymic carcinoma. Int J Clin Oncol; 2010 Apr;15(2):220-3
MedlinePlus Health Information. consumer health - Thymus Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Erythrocytosis caused by erythropoietin-producing thymic carcinoma.
  • We describe the first reported case, in an 82-year-old man, of erythrocytosis caused by an erythropoietin (EPO)-producing thymic carcinoma.
  • The patient underwent computed tomography-guided fine-needle aspiration of a 6-cm anterior mediastinal mass, and histological findings revealed thymic squamous cell carcinoma.
  • [MeSH-major] Carcinoma, Squamous Cell / metabolism. Erythropoietin / metabolism. Paraneoplastic Syndromes / etiology. Polycythemia / etiology. Thymoma / metabolism. Thymus Neoplasms / metabolism

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  • (PMID = 20179983.001).
  • [ISSN] 1437-7772
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 11096-26-7 / Erythropoietin
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43. Hsueh C, Kuo TT, Tsang NM, Wu YC, Yang CP, Hung IJ: Thymic lymphoepitheliomalike carcinoma in children: clinicopathologic features and molecular analysis. J Pediatr Hematol Oncol; 2006 Dec;28(12):785-90
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Thymic lymphoepitheliomalike carcinoma in children: clinicopathologic features and molecular analysis.
  • Thymic lymphoepitheliomalike carcinoma (LELC) in children is extremely rare and we report 2 such cases with molecular analysis of Epstein-Barr virus (EBV) and its encoded latent membrane protein-1 as well as a literature review.
  • Both of our patients were male, presented with a huge anterior mediastinal mass, expired within a year after diagnosis despite treatment.
  • [MeSH-major] Carcinoma. Epstein-Barr Virus Infections. Mediastinal Neoplasms. Osteoarthropathy, Primary Hypertrophic. Thymus Neoplasms. Viral Matrix Proteins / genetics

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  • (PMID = 17164646.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / EBV-associated membrane antigen, Epstein-Barr virus; 0 / Viral Matrix Proteins
  • [Number-of-references] 39
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44. Riquet M, Berna P, Brian E, Badia A, Vlas C, Bagan P, Le Pimpec Barthes F: Intrathoracic lymph node metastases from extrathoracic carcinoma: the place for surgery. Ann Thorac Surg; 2009 Jul;88(1):200-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intrathoracic lymph node metastases from extrathoracic carcinoma: the place for surgery.
  • BACKGROUND: Intrathoracic hilar or mediastinal lymph node metastases (HMLNMs) of extrathoracic carcinomas are infrequent.
  • METHODS: Among 565 patients with mediastinal lymph node enlargement, 37 had a history of extrathoracic carcinoma.
  • RESULTS: Diagnostic procedures, comprising mediastinoscopy in 9, anterior mediastinotomy in 2, and video-assisted thoracic surgery (VATS) in 4, were performed mainly because of unresectability due to diffuse and bilateral HMLNMs.
  • CONCLUSIONS: HMLNMs of extrathoracic carcinoma may be isolated, probably in the context of a particular lymphatic mode of spread.
  • [MeSH-major] Cause of Death. Lymph Node Excision / methods. Mediastinal Neoplasms / mortality. Mediastinal Neoplasms / surgery. Neoplasms / mortality. Neoplasms / surgery

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  • [CommentIn] Ann Thorac Surg. 2009 Jul;88(1):205 [19559226.001]
  • (PMID = 19559225.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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45. Posligua L, Ylagan L: Fine-needle aspiration cytology of thymic basaloid carcinoma: case studies and review of the literature. Diagn Cytopathol; 2006 May;34(5):358-66
MedlinePlus Health Information. consumer health - Thymus Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fine-needle aspiration cytology of thymic basaloid carcinoma: case studies and review of the literature.
  • To the best of our knowledge, this is the first fine-needle aspiration (FNA) report on basaloid carcinoma of the thymus.
  • This is a tumor in which the FNA diagnosis is difficult and the differential diagnosis is broad.
  • We describe the cytologic features encountered in the three cases, and immunohistochemical and ultrastructural findings so as to raise awareness of this entity in the differential diagnosis of thymic neoplasms on FNABs.
  • The cases studied included three male patients, aged 73, 65, and 50, who presented with anterior mediastinal masses, with no primary tumor elsewhere.
  • The diagnoses on all three cases were thymic basaloid carcinoma.
  • [MeSH-major] Biopsy, Fine-Needle / methods. Carcinoma, Basosquamous / pathology. Thymus Neoplasms / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Cell Nucleus / ultrastructure. Cytoplasm / ultrastructure. Desmosomes / ultrastructure. Humans. Immunoenzyme Techniques. Lymph Nodes / pathology. Lymphatic Metastasis. Male. Mediastinal Cyst / pathology. Microscopy, Electron, Transmission. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 16604555.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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46. Saint-Blancard P, Andriamparany J, Arigon JP, Margery J: [Lymph node supraclavicular metastasis of thymic carcinoma: an inaugural and unusual feature of a rare disease]. Rev Pneumol Clin; 2010 Oct;66(5):330-4
MedlinePlus Health Information. consumer health - Thymus Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Lymph node supraclavicular metastasis of thymic carcinoma: an inaugural and unusual feature of a rare disease].
  • More than one-third of cases present lymph node metastasis during an evaluation of the extension of a primitive mediastinal tumour of thymic origin.
  • The diagnosis of epidermoid thymic carcinoma was based on the histopathological examination of a right supraclavicular lymph node, associated with an anterior radiological mediastinal tumoral syndrome, raising the delicate problem of its diagnosis and treatment.
  • [MeSH-minor] Clavicle. Diagnosis, Differential. Female. Humans. Mediastinal Neoplasms / diagnosis. Middle Aged. Neoadjuvant Therapy. Neoplasm Invasiveness. Neoplasm Staging

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  • [Copyright] Copyright © 2009 Elsevier Masson SAS. All rights reserved.
  • (PMID = 21087730.001).
  • [ISSN] 0761-8417
  • [Journal-full-title] Revue de pneumologie clinique
  • [ISO-abbreviation] Rev Pneumol Clin
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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47. Moran CA, Suster S: Cystic well-differentiated neuroendocrine carcinoma (carcinoid tumor): a clinicopathologic and immunohistochemical study of two cases. Am J Clin Pathol; 2006 Sep;126(3):377-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cystic well-differentiated neuroendocrine carcinoma (carcinoid tumor): a clinicopathologic and immunohistochemical study of two cases.
  • Two cases of primary neuroendocrine carcinoma (carcinoid tumor) arising in the walls of a multilocular thymic cyst (MTC) are described.
  • Radiographic evaluation demonstrated the presence of anterior mediastinal tumor in both patients, and complete surgical resection of the tumor mass was performed.
  • [MeSH-major] Carcinoid Tumor / pathology. Carcinoma, Neuroendocrine / pathology. Mediastinal Cyst / pathology. Mediastinal Neoplasms / pathology

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  • (PMID = 16880146.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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48. Muro M, Kubo S, Yoshioka T, Idani H, Ishikawa T, Ishii T, Asami S, Kurose Y, Hirata M, Yamashita T, Kin H: [Thymic carcinoma; report of a case]. Kyobu Geka; 2009 Feb;62(2):169-71
MedlinePlus Health Information. consumer health - Thymus Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Thymic carcinoma; report of a case].
  • Chest computed tomography scan and magnetic resonance imaging demonstrated an anterior mediastinal tumor.
  • Microscopically, the tumor was diagnosed thymic cancer, basaloid carcinoma.
  • We reported a case of thymic carcinoma.
  • [MeSH-major] Carcinoma, Transitional Cell / surgery. Thymus Neoplasms / surgery

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  • (PMID = 19202942.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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49. Ishibashi H, Akamatsu H, Kojima K, Usui H, Akashi T, Sunamori M: Good syndrome with thymic adenosquamous carcinoma--report of a case. Ann Thorac Cardiovasc Surg; 2007 Feb;13(1):50-2
MedlinePlus Health Information. consumer health - Thymus Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Good syndrome with thymic adenosquamous carcinoma--report of a case.
  • A 68-year-old man with recurrent bilateral severe pneumonia and invasive thymic carcinoma was admitted to our hospital.
  • An extended thymo-thymectomy with lymph nodes dissection was performed for an irregular shaped anterior mediastinum mass.
  • The tumor was mainly composed of type C, adenosquamous carcinoma, and found to have a small area of types B2 and B3 thymoma.
  • History and laboratory findings were compatible with the diagnosis of Good syndrome.
  • Although there are some reports of thymic carcinoma arising from thymoma, this is the first report of co-existence of adenosquamous carcinomas and thymoma with Good syndrome as far as reviewed articles.
  • Thymic carcinoma with severe infection should be examined carefully for co-existence of thymoma, and co-existence of thymoma and thymic carcinoma suggests a close histogenetic relationship between the 2 tumors.
  • [MeSH-major] Carcinoma, Adenosquamous. Paraneoplastic Syndromes. Thymoma. Thymus Neoplasms
  • [MeSH-minor] Aged. Humans. Lymph Node Excision. Male. Mediastinal Neoplasms / secondary. Mediastinal Neoplasms / surgery. Neoplasm Invasiveness. Thymectomy

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  • (PMID = 17392673.001).
  • [ISSN] 1341-1098
  • [Journal-full-title] Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia
  • [ISO-abbreviation] Ann Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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50. Noda T, Higashiyama M, Oda K, Higaki N, Takami K, Okami J, Kodama K, Kuriyama K, Tsukamoto Y, Kobayashi H: Mucoepidermoid carcinoma of the thymus treated by multimodality therapy: a case report. Ann Thorac Cardiovasc Surg; 2006 Aug;12(4):273-8
MedlinePlus Health Information. consumer health - Thymus Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mucoepidermoid carcinoma of the thymus treated by multimodality therapy: a case report.
  • A case report of mucoepidermoid carcinoma of the thymus, aggressively treated by multimodality therapy including surgery, radiotherapy, chemothermotherapy, and systemic chemotherapy is presented.
  • The patient, a 53-year-old man, underwent potentially complete resection for an anterior mediastinal tumor, histologically diagnosed as a mucoepidermoid carcinoma of the thymus with Masaoka stage II disease.
  • Although the clinical aspects of thymic mucoepidermoid carcinoma are little known, it is assumed that such aggressive therapeutic multimodalities as repeated surgical resection, irradiation and chemothermotherapy, and chemotherapy based on in vitro chemosensitivity tests contributed to long-term survival for this unusual disease.
  • [MeSH-major] Carcinoma, Mucoepidermoid / secondary. Carcinoma, Mucoepidermoid / therapy. Mediastinal Neoplasms / secondary. Mediastinal Neoplasms / therapy. Thymus Neoplasms / pathology. Thymus Neoplasms / therapy

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  • (PMID = 16977299.001).
  • [ISSN] 1341-1098
  • [Journal-full-title] Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia
  • [ISO-abbreviation] Ann Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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51. Barreda T, Laali M, Dorent R, Acar C: Left thoracotomy for aortic and mitral valve surgery in a case of mediastinal displacement due to pneumonectomy. J Heart Valve Dis; 2008 Mar;17(2):239-42

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Left thoracotomy for aortic and mitral valve surgery in a case of mediastinal displacement due to pneumonectomy.
  • Four years earlier, he had undergone a left pneumonectomy for a bronchial carcinoma.
  • Due to the severe shift of the mediastinum into the left chest, as well as to adhesions of the right lung to the sternum, a median sternotomy was thought undesirable.
  • AVR was performed through a left anterior thoracotomy through the fourth intercostal space.
  • [MeSH-minor] Bronchial Neoplasms / surgery. Humans. Male. Mediastinum / pathology. Middle Aged. Reoperation. Tomography, X-Ray Computed

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  • (PMID = 18512498.001).
  • [ISSN] 0966-8519
  • [Journal-full-title] The Journal of heart valve disease
  • [ISO-abbreviation] J. Heart Valve Dis.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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52. Bouaziz H, Kaffel N, Charfi N, Fourati M, Abid H, Abid M: [Panhypopituitarism revealing metastasis of small-cell lung carcinoma associated with sarcoidosis]. Ann Endocrinol (Paris); 2006 Jun;67(3):259-64
MedlinePlus Health Information. consumer health - Sarcoidosis.

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  • [Title] [Panhypopituitarism revealing metastasis of small-cell lung carcinoma associated with sarcoidosis].
  • In this setting, we report a case of panhypopituitarism revealing pituitary metastasis from a small-cell lung carcinoma associated with sarcoidosis.
  • Hormone explorations confirmed anterior pituitary insufficiency.
  • The thoraco-abdominal scan demonstrated a mass in the left lung highly suggestive of malignancy and many enlarged mediastinal nodes, hepatic nodules, and hypertrophy of the left adrenal.
  • The diagnosis of sarcoidosis was incompatible with the deterioration of the patient's general status.
  • Subsequent radiographic explorations showed an increase in the size of the tumor mass and histological evaluation of a scan-guided trans-thoracic biopsy demonstrated small-cell carcinoma.
  • Small-cell lung carcinoma is the most common cancer with pituitary metastasis.
  • [MeSH-major] Carcinoma, Small Cell / pathology. Hypopituitarism / etiology. Lung Neoplasms / pathology. Pituitary Neoplasms / secondary. Sarcoidosis / etiology


53. Tacyildiz N, Ugur H, Yavuz G, Unal E, Comba A, Okten I, Ciftci E, Dogru U, Heper AO, Sak SD: The coexistence of thymic carcinoma and multiple granulomas in a Turkish child. Pediatr Hematol Oncol; 2007 Jun;24(4):301-7

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  • [Title] The coexistence of thymic carcinoma and multiple granulomas in a Turkish child.
  • Thymic carcinoma, which is a thymic epithelial neoplasm with obvious cytologic atypia, is a rare neoplasm.
  • The authors report on a 10-year-old boy who presented with respiratory distress due to bulky anterior mediastinal mass.
  • Histological and immunohistochemical studies confirmed a lymphoepithelioma-like pattern thymic carcinoma.
  • Two years after cessation of treatment, he is still in remission for thymic carcinoma.

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  • (PMID = 17613873.001).
  • [ISSN] 1521-0669
  • [Journal-full-title] Pediatric hematology and oncology
  • [ISO-abbreviation] Pediatr Hematol Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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54. Mega S, Oguri M, Kawasaki R, Hazama K, Iwai K, Kondo S: Large-cell neuroendocrine carcinoma in the thymus. Gen Thorac Cardiovasc Surg; 2008 Nov;56(11):566-9
MedlinePlus Health Information. consumer health - Thymus Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Large-cell neuroendocrine carcinoma in the thymus.
  • Large-cell neuroendocrine carcinoma in the thymus is a rare cancer that is more aggressive and leads to a poorer prognosis than other thymic epithelial tumors.
  • A 67-year-old woman presented with an anterior mediastinal mass in the thymus.
  • Histological examination after thymectomy revealed large-cell neuroendocrine carcinoma in the thymus.
  • There is no evidence of to support postoperative therapy for large-cell neuroendocrine carcinoma in the thymus.
  • [MeSH-major] Carcinoma, Neuroendocrine. Thymus Neoplasms

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  • (PMID = 19002759.001).
  • [ISSN] 1863-6705
  • [Journal-full-title] General thoracic and cardiovascular surgery
  • [ISO-abbreviation] Gen Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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55. Takahashi F, Tsuta K, Nagaoka T, Miyamoto H, Saito Y, Amano H, Uchida K, Morio Y, Shimizu K, Sasaki S, Tominaga S, Uekusa T, Izumi H, Anami Y, Matsuno Y, Takahashi K, Fukuchi Y: Successful resection of dermatomyositis associated with thymic carcinoma: report of a case. Surg Today; 2008;38(3):245-8
MedlinePlus Health Information. consumer health - Thymus Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Successful resection of dermatomyositis associated with thymic carcinoma: report of a case.
  • We report a case of thymic carcinoma associated with dermatomyositis (DM) in a 53-year-old man.
  • Comprehensive clinical examinations revealed an anterior mediastinal tumor.
  • We resected the tumor and histological examination confirmed squamous cell carcinoma of the thymus.
  • Our search of the literature found only one other case report of DM accompanied by thymic carcinoma, and to our knowledge, this is the fi rst documented case of dramatic improvement of DM after resection of thymic carcinoma.
  • We propose that thymic carcinoma should be added to the list of malignancies that can complicate DM as a paraneoplastic disease.

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  • (PMID = 18306999.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] Q1J152VB1P / Bromhexine
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56. Noriyuki T, Hamamoto M, Takazawa Y, Katoh K, Hashimoto M, Kuranishi F, Nakahara M, Fukuda T, Ishizaki Y, Okuda H, Akimoto E, Yonehara S: [Thymic carcinoma involving aortic arch; report of a case]. Kyobu Geka; 2009 May;62(5):417-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Thymic carcinoma involving aortic arch; report of a case].
  • The standard treatment for advanced thymic carcinoma has not yet been established, and the prognosis is poor.
  • We report a case of thymic carcinoma that involving the aortic arch and the innominate vein.
  • The computed tomography (CT) scan showed an anterior mediastinal tumor contiguous to the aortic arch and the innominate vein with swelling lymphnodes.
  • Thymic carcinoma was diagnosed.

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  • (PMID = 19425386.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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57. Washino S, Terauchi F, Matsuzaki A, Kobayashi Y: [Two cases of squamous cell carcinoma of upper urinary tract with hypercalcemia]. Nihon Hinyokika Gakkai Zasshi; 2008 Sep;99(6):703-8
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  • [Title] [Two cases of squamous cell carcinoma of upper urinary tract with hypercalcemia].
  • We report two cases of squamous cell carcinoma of upper urinary tract with hypercalcemia.
  • Case 1; a 54 year old female with primary squamous cell carcinoma (SCC) of right ureter showed marked hypercalcemia and leukocytosis.
  • Case 2; a 54 year old male of primary SCC of right renal pelvis with local lymphadenopathy and anterior mediastinal metastases showed marked hypercalcemia.
  • Although the patient was administered UFT with palliative radiotherapy to the anterior mediastinum, he died 2 months after the initiation of therapy.
  • To our knowledge, the case 1 is the third case that of the high levels of serum PTHrP and G-CSF simultaneously in squamous cell carcinoma of upper urinary tract.
  • [MeSH-major] Carcinoma, Squamous Cell / complications. Hypercalcemia / etiology. Kidney Neoplasms / complications. Kidney Pelvis. Ureteral Neoplasms / complications

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  • (PMID = 18939454.001).
  • [ISSN] 0021-5287
  • [Journal-full-title] Nihon Hinyōkika Gakkai zasshi. The japanese journal of urology
  • [ISO-abbreviation] Nippon Hinyokika Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Parathyroid Hormone-Related Protein; 143011-72-7 / Granulocyte Colony-Stimulating Factor; 1548R74NSZ / Tegafur; 56HH86ZVCT / Uracil; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil; 1-UFT protocol
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58. Iacovelli R, Palazzo A, Conte D, Fabbri MA, Vitolo D, Cortesi E: Dermatomyositis as first clinical appearance for a thymic epidermoid cell carcinoma. Acta Biomed; 2010 Dec;81(1):68-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dermatomyositis as first clinical appearance for a thymic epidermoid cell carcinoma.
  • Primary thymic carcinoma is a rare and heterogeneous group of tumours of the anterior mediastinum that includes different histological types.
  • A left deltoid muscle biopsy specimen showed a histological pattern compatible with the diagnosis of dermatomyositis.
  • A computed tomography of the chest, abdomen and pelvis, showed a solid mass in the upper anterior mediastinal area and a mediastinoscopy with mass-biopsy was performed.
  • Only the immunohistochemical staining technique allowed a definitive histological diagnosis.

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  • (PMID = 20857855.001).
  • [ISSN] 0392-4203
  • [Journal-full-title] Acta bio-medica : Atenei Parmensis
  • [ISO-abbreviation] Acta Biomed
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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59. Kusaba H, Fujihara M, Nagashima R, Kaji Y, Baba E, Nakano S: Systemic chemotherapy of TS-1 and cisplatin for gastric signet-ring cell carcinoma presenting as cardiac tamponade. Med Oncol; 2008;25(2):241-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Systemic chemotherapy of TS-1 and cisplatin for gastric signet-ring cell carcinoma presenting as cardiac tamponade.
  • A 59-year-old man complaining of dyspnea, anterior chest oppression, and hypotension was diagnosed to have cardiac tamponade due to massive pericardial effusion.
  • An endoscopic study revealed gastric cancer in the lesser curvature wall of the middle body of the stomach, and signet-ring cell carcinoma was confirmed histologically.
  • The gastric cancer was complicated by malignant pericardial effusion, and metastasis to the mediastinal lymph nodes.
  • Our experience suggests that the systemic chemotherapy of TS-1 and CDDP may be effective for controlling advanced gastric signet-cell carcinoma accompanied by malignant pericardial effusion.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Signet Ring Cell / drug therapy. Cardiac Tamponade / etiology. Stomach Neoplasms / drug therapy

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  • (PMID = 18488163.001).
  • [ISSN] 1357-0560
  • [Journal-full-title] Medical oncology (Northwood, London, England)
  • [ISO-abbreviation] Med. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Drug Combinations; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid; Q20Q21Q62J / Cisplatin
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60. Fuse ET, Kamimura M, Takeda Y, Kawaishi M, Kimura S, Niino H, Saito K, Kobayashi N, Kudo K: Response of a thymic mucoepidermoid carcinoma to combination chemotherapy with cisplatin and irinotecan: a case report. Lung Cancer; 2008 Mar;59(3):403-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Response of a thymic mucoepidermoid carcinoma to combination chemotherapy with cisplatin and irinotecan: a case report.
  • A chemotherapeutic regimen for advanced thymic carcinoma has not yet been established.
  • We describe a patient with advanced thymic mucoepidermoid carcinoma who achieved a complete response to combination chemotherapy with cisplatin (Randa) and irinotecan hydrochloride (Campto).
  • Chest computed tomography examinations revealed an anterior mediastinal tumour (5.5cmx3.5cmx9.5cm) that had invaded the subcutis through the sternum.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Mucoepidermoid / drug therapy. Thymus Neoplasms / drug therapy

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  • (PMID = 17707547.001).
  • [ISSN] 0169-5002
  • [Journal-full-title] Lung cancer (Amsterdam, Netherlands)
  • [ISO-abbreviation] Lung Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 7673326042 / irinotecan; Q20Q21Q62J / Cisplatin; XT3Z54Z28A / Camptothecin
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61. Kato D, Achiwa H, Sato S, Bessho Y, Shimizu S, Hattori N, Maeda H, Niimi T, Oguri T, Ueda R: [A case of thymic carcinoma responding to combination chemotherapy with nedaplatin, etoposide, and ifosfamide]. Gan To Kagaku Ryoho; 2005 Mar;32(3):377-9
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  • [Title] [A case of thymic carcinoma responding to combination chemotherapy with nedaplatin, etoposide, and ifosfamide].
  • We described a case of thymic carcinoma that responded remarkably to combined chemotherapy with etoposide (ETP), ifosfamide (IFO) and nedaplatin.
  • Chest computed tomographic (CT) scans showed an anterior mediastinal tumor.
  • Using CT-guided needle biopsy, the diagnosis was squamous cell type of thymic carcinoma.
  • This case suggested that nedaplatin may be one of the promising agents for thymic carcinoma chemotherapy.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Squamous Cell / drug therapy. Thymus Neoplasms / drug therapy

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  • (PMID = 15791821.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; 6PLQ3CP4P3 / Etoposide; 8UQ3W6JXAN / nedaplatin; UM20QQM95Y / Ifosfamide
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62. Arora R, Gupta R, Sharma A, Dinda AK: Primary neuroendocrine carcinoma of thymus: a rare cause of Cushing's syndrome. Indian J Pathol Microbiol; 2010 Jan-Mar;53(1):148-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary neuroendocrine carcinoma of thymus: a rare cause of Cushing's syndrome.
  • In contrast, neuroendocrine tumors (carcinoid and neuroendocrine carcinoma) of thymus are extremely rare.
  • We describe three cases of rare atypical carcinoid tumor (neuroendocrine carcinoma) of the thymus.
  • Computed tomography (CT) scans of chest in all three patients revealed anterior mediastinal mass.
  • The features suggested a diagnosis of atypical carcinoid tumor in all the three cases.
  • Atypical carcinoid (neuroendocrine carcinoma, well-differentiated and moderately-differentiated) of the thymus is a rare thymic tumor which carries a worse prognosis compared to thymoma and requires aggressive therapy.
  • Hence, an accurate diagnosis is essential.
  • [MeSH-major] Carcinoma, Neuroendocrine / complications. Carcinoma, Neuroendocrine / diagnosis. Cushing Syndrome / etiology. Thymus Gland / pathology. Thymus Neoplasms / complications. Thymus Neoplasms / diagnosis

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  • (PMID = 20090249.001).
  • [ISSN] 0974-5130
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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63. Hamazoe R, Sakimura C, Iwamoto A, Yamane N, Kimura O: [A case of hepatocellular carcinoma of the caudate lobe relapsing with variable patterns after hepatectomy]. Gan To Kagaku Ryoho; 2007 Nov;34(12):2084-6
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  • [Title] [A case of hepatocellular carcinoma of the caudate lobe relapsing with variable patterns after hepatectomy].
  • Computed tomography of the abdomen revealed a huge extrahepatically growing tumor which was originating from the caudate lobe and extended to the posterior segment of the right lobe of the liver and encircled the anterior half of inferior vena cava.
  • Radiation therapy was effective to mediastinal lymph nodes metastasized in 25 months after the initial surgery.
  • Therefore, the multidisplinary therapy combined with radiation and surgery for hepatocellular carcinoma of the caudate lobe may have improved a long-term survival.
  • [MeSH-major] Brain Neoplasms / secondary. Carcinoma, Hepatocellular / pathology. Caudate Nucleus / pathology. Hepatectomy. Liver Neoplasms / pathology

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  • (PMID = 18219906.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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64. Ayabe E, Kaira K, Takahashi T, Murakami H, Tsuya A, Nakamura Y, Naito T, Endo M, Yamamoto N: Thymic squamous cell carcinoma producing granulocyte colony-stimulating factor associated with a high serum level of interleukin 6. Int J Clin Oncol; 2009 Dec;14(6):534-6
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  • [Title] Thymic squamous cell carcinoma producing granulocyte colony-stimulating factor associated with a high serum level of interleukin 6.
  • Granulocyte colony-stimulating factor (G-CSF)-producing thymic carcinoma is extremely rare.
  • A-66-year-old man presented with an anterior mediastinal mass, and underwent surgical biopsy.
  • Histologically, the tumor consisted of squamous cell carcinoma, which showed positive immunoreactivity for G-CSF.
  • He was doing well at 8 months after tumor diagnosis.
  • [MeSH-major] Carcinoma, Squamous Cell / metabolism. Granulocyte Colony-Stimulating Factor / metabolism. Interleukin-6 / blood. Thymus Neoplasms / metabolism

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  • [ErratumIn] Int J Clin Oncol. 2010 Feb;15(1):116
  • [Cites] Intern Med. 1998 Apr;37(4):414-6 [9630206.001]
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  • (PMID = 19967491.001).
  • [ISSN] 1437-7772
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Interleukin-6; 143011-72-7 / Granulocyte Colony-Stimulating Factor
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65. Hashimoto H, Oshika Y, Obara K, Sato K, Matsukuma S, Tanaka Y: [Advanced thymic carcinoma effectively treated by surgical resection and postoperative radiation therapy: report of a case]. Kyobu Geka; 2010 May;63(5):415-8
MedlinePlus Health Information. consumer health - Thymus Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Advanced thymic carcinoma effectively treated by surgical resection and postoperative radiation therapy: report of a case].
  • We reported a case of advanced thymic carcinoma effectively treated by surgical resection and postoperative radiation therapy.
  • Chest computed tomography (CT) scan demonstrated an anterior mediastinal tumor.
  • The tumor was diagnosed as carcinoma by CT-guided tumor biopsy and was extirpated completely with combined partial resection of the left lung.
  • Microscopically, the tumor was diagnosed as thymic carcinoma with direct invasion to the left lung.
  • [MeSH-major] Carcinoma / surgery. Thymus Neoplasms / surgery

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  • (PMID = 20446613.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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66. Cameron SE, Alsharif M, McKeon D, Pambuccian SE: Cytology of metastatic thymic well-differentiated neuroendocrine carcinoma (thymic carcinoid) in pleural fluid: report of a case. Diagn Cytopathol; 2008 May;36(5):333-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytology of metastatic thymic well-differentiated neuroendocrine carcinoma (thymic carcinoid) in pleural fluid: report of a case.
  • Thymic carcinoid tumors (well-differentiated neuroendocrine carcinomas) are uncommon anterior mediastinal neoplasms.
  • These findings were consistent with metastatic well-differentiated neuroendocrine carcinoma (carcinoid tumor).

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  • (PMID = 18418883.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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67. Shimizu Y, Tsunezuka Y, Tanaka N: [A case of unresectable advanced thymic carcinoma in an elderly woman responding to S-1 with good QOL maintained]. Gan To Kagaku Ryoho; 2008 Nov;35(11):1977-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of unresectable advanced thymic carcinoma in an elderly woman responding to S-1 with good QOL maintained].
  • Because an anterior mediastinum tumor was noted by CT performed in the case of additional workup of left precordial pain noticed from approximately two months ago, she was admitted to our institution.
  • After hospitalization, CT-guided biopsy was performed, but did not lead to diagnosis.
  • Therefore, surgical biopsy was performed and the diagnosis was advanced thymic carcinoma with metastasis to the mediastinal lymph node, pericardium invasion and left lung invasion.

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  • (PMID = 19011356.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Drug Combinations; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid
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68. Walid MS, Troup EC, Robinson JS Jr: Brain metastasis from thymic carcinoma in association with SIADH and pituitary enlargement: a case report. South Med J; 2008 Jul;101(7):764-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Brain metastasis from thymic carcinoma in association with SIADH and pituitary enlargement: a case report.
  • Thorax CT revealed a large anterior mediastinal mass measuring 6.3 x 3.6 cm.
  • Pathology revealed a poorly differentiated carcinoma arising from the thymus.
  • [MeSH-major] Brain Neoplasms / complications. Inappropriate ADH Syndrome / complications. Pituitary Gland / pathology. Thymoma / complications. Thymus Neoplasms / diagnosis

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  • (PMID = 18580715.001).
  • [ISSN] 1541-8243
  • [Journal-full-title] Southern medical journal
  • [ISO-abbreviation] South. Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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69. Ogawa F, Iyoda A, Amano H, Nezu K, Jiang SX, Okayasu I, Satoh Y: Thymic large cell neuroendocrine carcinoma: report of a resected case - a case report. J Cardiothorac Surg; 2010;5:115
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Thymic large cell neuroendocrine carcinoma: report of a resected case - a case report.
  • A 55-year-old male was admitted to our hospital for treatment of an anterior mediastinal tumor found at a regular health check-up.
  • Final pathological diagnosis of the surgical specimen was thymic LCNEC.
  • The patient underwent adjuvant chemotherapy with irinotecan and cisplatin in accordance with the diagnosis of a lung LCNEC, and is alive without recurrence or metastasis 16 months after surgery.
  • [MeSH-major] Carcinoma, Large Cell / surgery. Carcinoma, Neuroendocrine / surgery. Thymus Neoplasms / surgery
  • [MeSH-minor] Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Thymectomy. Tomography, X-Ray Computed

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  • [Cites] N Engl J Med. 2002 Jan 10;346(2):85-91 [11784874.001]
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  • (PMID = 21092193.001).
  • [ISSN] 1749-8090
  • [Journal-full-title] Journal of cardiothoracic surgery
  • [ISO-abbreviation] J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2995793
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70. Okubo K, Kobayashi M, Morikawa H, Hayatsu E: Easier node dissection after chemoradiotherapy for lung cancer with collagen insertion at mediastinoscopy. Jpn J Thorac Cardiovasc Surg; 2006 Jul;54(7):268-72
MedlinePlus Health Information. consumer health - Lung Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: Induction chemoradiotherapy followed by anatomical resection is a current therapeutic strategy for non-small-cell lung cancer with mediastinal node involvement.
  • Dense peritracheal fibrosis and sclerosis after chemoradiotherapy cause difficult mediastinal node dissection.
  • We evaluated a novel technique to make the mediastinal node dissection easier after induction therapy.
  • METHODS: At the end of mediastinoscopic node biopsy for staging of lung cancer, cotton-type collagen was inserted anterior and lateral to the trachea in patients with pathologically confirmed mediastinal node involvement (n=45).
  • After the chemoradiotherapy all patients underwent a pulmonary resection with complete mediastinal node dissection 7-12 weeks after the collagen insertion.
  • Surgical findings of the mediastinum and the time for node dissection were compared with those without collagen insertion at mediastinoscopy after chemoradiotherapy (n=5).
  • RESULTS: All five patients without collagen insertion showed sclerotic and fibrotic change of mediastinal nodes with severe adhesion to the trachea.
  • In 42 of 45 patients with collagen insertion (93.3%) the collagen remained unabsorbed and separated the mediastinal nodes from the trachea.
  • Mediastinal node dissection was easily accomplished by removing mediastinal tissues lateral and anterior to the collagen.
  • The rate of mediastinal node separation was significantly higher with collagen insertion than without (p<0.0001).
  • CONCLUSION: Cotton-type collagen insertion at staging mediastinoscopy for lung cancer separates the mediastinal nodes from the trachea and makes the node dissection easier after induction chemoradiotherapy.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / diagnosis. Carcinoma, Non-Small-Cell Lung / therapy. Collagen / therapeutic use. Lung Neoplasms / diagnosis. Lung Neoplasms / therapy. Lymph Node Excision. Mediastinal Neoplasms / diagnosis. Mediastinal Neoplasms / surgery. Mediastinoscopy

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  • (PMID = 16898638.001).
  • [ISSN] 1344-4964
  • [Journal-full-title] The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai zasshi
  • [ISO-abbreviation] Jpn. J. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 9007-34-5 / Collagen
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71. Moran CA, Suster S: Primary parathyroid tumors of the mediastinum: a clinicopathologic and immunohistochemical study of 17 cases. Am J Clin Pathol; 2005 Nov;124(5):749-54

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary parathyroid tumors of the mediastinum: a clinicopathologic and immunohistochemical study of 17 cases.
  • We describe 17 cases (9 women, 8 men; aged 36 to 72 years) of primary parathyroid tumors occurring primarily in the anterior mediastinum.
  • Clinically and radiologically, all patients had an anterior mediastinal tumor.
  • Of 17 patients, 13 had clinical primary hyperparathyroidism, 1 had secondary hyperparathyroidism due to polycystic kidney disease, and 1 had a history of prostatic carcinoma and 1 of chronic obstructive pulmonary disease.
  • Histologically, 2 tumors showed features of parathyroid carcinoma, and 15 tumors showed more conventional features of parathyroid adenomas.
  • The cases highlight the importance of keeping primary parathyroid tumors in the differential diagnosis of anterior mediastinal tumors.
  • [MeSH-major] Mediastinal Neoplasms / pathology. Parathyroid Neoplasms / pathology

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  • (PMID = 16203274.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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72. Restrepo CS, Pandit M, Rojas IC, Villamil MA, Gordillo H, Lemos D, Mastrogiovanni L, Diethelm L: Imaging findings of expansile lesions of the thymus. Curr Probl Diagn Radiol; 2005 Jan-Feb;34(1):22-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Almost 50% of all mediastinal masses are located in the anterior mediastinum.
  • Primary neoplasms of the thymus are thymoma, thymolipomas, carcinoma, carcinoid, primary germ cell tumors, and lymphoma.
  • Even though anterior mediastinal masses are first found on conventional radiographs, computed tomography and magnetic resonance are very useful additional studies for assessing the origin and extension of these masses.
  • The basic concepts regarding embryology, anatomy, and histology relevant for the differential diagnosis of an enlarged thymic gland are also described.
  • [MeSH-major] Lymphatic Diseases / diagnosis. Thymus Gland. Thymus Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Magnetic Resonance Imaging. Mediastinal Cyst / diagnosis. Mediastinal Cyst / radiography. Radiography, Thoracic. Tomography, X-Ray Computed

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  • (PMID = 15644860.001).
  • [ISSN] 0363-0188
  • [Journal-full-title] Current problems in diagnostic radiology
  • [ISO-abbreviation] Curr Probl Diagn Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 32
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73. Karthik S, Milton R, Papagiannopoulos K: Simultaneous double video mediastinoscopy and video mediastinotomy--a step forward. Eur J Cardiothorac Surg; 2005 May;27(5):920-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Mediastinal lymph node biopsy plays a fundamental role in diagnosis, staging and management of lung cancer.
  • We describe a novel method of using the video-mediastinoscope for concurrent cervical mediastinotomy and anterior mediastinoscopy.
  • In the fifth case, we performed a cervical mediastinoscopy for para-tracheal and sub-carinal lymphadenopathy followed by an anterior videomediastinotomy, video assisted intrapericardial assessment, direct tumour sampling and A-P window lymph nodal biopsies.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / secondary. Lung Neoplasms / secondary. Mediastinal Neoplasms / pathology. Mediastinoscopy / methods

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  • (PMID = 15848339.001).
  • [ISSN] 1010-7940
  • [Journal-full-title] European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • [ISO-abbreviation] Eur J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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74. El-Bawab H, Al-Sugair AA, Rafay M, Hajjar W, Mahdy M, Al-Kattan K: Role of flourine-18 fluorodeoxyglucose positron emission tomography in thymic pathology. Eur J Cardiothorac Surg; 2007 Apr;31(4):731-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The indication for CT was myasthenia gravis in 10, anterior mediastinal mass in 7, and recurrent thymic tumor after surgical excision in 8 patients.
  • RESULTS: All mediastinal abnormal thymic tissue showed FDG uptakes.
  • There were no false-negative results for both CT and FDG-PET in seven patients with thymoma presented as anterior mediastinal mass.
  • However, PET scan predicted thymic carcinoma in one patient.
  • FDG-PET may differentiate thymoma from thymic carcinoma.
  • [MeSH-minor] Adolescent. Adult. Aged. Choristoma / complications. Choristoma / radionuclide imaging. Diagnosis, Differential. Female. Humans. Hyperplasia / radionuclide imaging. Male. Mediastinal Diseases / complications. Mediastinal Diseases / radionuclide imaging. Mediastinum / pathology. Mediastinum / radionuclide imaging. Middle Aged. Myasthenia Gravis / complications. Myasthenia Gravis / radionuclide imaging. Neoplasm Recurrence, Local / radionuclide imaging. Recurrence. Tomography, X-Ray Computed / methods

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  • (PMID = 17293120.001).
  • [ISSN] 1010-7940
  • [Journal-full-title] European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • [ISO-abbreviation] Eur J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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75. Saint-Blancard P, Harket A, Bonnichon A, Jancovici R: [Neurogenic spindle-cell tumors of the mediastinum: two cases]. Presse Med; 2008 Feb;37(2 Pt 1):229-34

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  • [Title] [Neurogenic spindle-cell tumors of the mediastinum: two cases].
  • They are commonly found, however, in the mediastinum, most often in its posterior compartment.
  • In the anterior compartment, they must be distinguished from their differential diagnoses.
  • CASES: We report one case of a malignant peripheral nerve sheath tumor in the posterior mediastinum of a 29-year-old man and another of a schwannoma of the anterior mediastinum, in an 82-year-old woman.
  • DISCUSSION: Neurogenic tumors of spindle-shaped cells in the mediastinum are generally benign, but can be malignant.
  • Often asymptomatic, they are usually detected on standard pulmonary radiography, but computerized tomography is necessary, supplemented by magnetic resonance imaging, especially for posterior mediastinal tumors, to provide additional information and to assess its possible extension to adjacent structures.
  • Radiographic, clinical, and especially histopathological features are essential for diagnosis.
  • [MeSH-major] Carcinoma. Mediastinal Neoplasms

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  • (PMID = 17988829.001).
  • [ISSN] 2213-0276
  • [Journal-full-title] Presse medicale (Paris, France : 1983)
  • [ISO-abbreviation] Presse Med
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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76. Cheng MF, Peng YJ, Huang GS, Lee CH, Chiang PC, Lee HS: Unusual scapular metastasis as initial manifestation of advanced nonseminomatous germ cell tumor of the mediastinum. Heart Lung; 2007 Jan-Feb;36(1):79-84
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  • [Title] Unusual scapular metastasis as initial manifestation of advanced nonseminomatous germ cell tumor of the mediastinum.
  • Primary malignant germ cell tumors of the mediastinum are relatively rare, occurring predominantly in young male adults, and have a poor prognosis.
  • Excisional biopsy of the scapula revealed a metastatic carcinoma, suggestive of nonseminomatous germ cell tumor origin.
  • Chest computed tomography and magnetic resonance imaging showed a primary tumor mass in the anterior mediastinum.
  • The mediastinal tumor mass was markedly reduced in size and remission without evidence of tracer uptake by [(18)F]fluorodeoxyglucose positron emission tomography examination.
  • Six months after chemotherapy, the patient received advanced surgical intervention to remove the mediastinal tumor, the pathologic features of which were similar to the previous scapular lesion.
  • [MeSH-major] Bone Neoplasms / secondary. Mediastinal Neoplasms / pathology. Neoplasms, Germ Cell and Embryonal / secondary. Scapula
  • [MeSH-minor] Adult. Biopsy. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male. Tomography, X-Ray Computed

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  • (PMID = 17234481.001).
  • [ISSN] 0147-9563
  • [Journal-full-title] Heart & lung : the journal of critical care
  • [ISO-abbreviation] Heart Lung
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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77. Khiria LS, Pal S, Peush S, Chattopadhyay TK, Deval M: Impact on outcome of the route of conduit transposition after transhiatal oesophagectomy: A randomized controlled trial. Dig Liver Dis; 2009 Oct;41(10):711-6
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  • METHODS: Patients with oesophageal carcinoma, undergoing transhiatal oesophagectomy (gastric conduit), were randomized to either anterior or posterior route of conduit transposition.
  • Patients with advanced tumour, distant metastasis, extensive invasion of the stomach, previous gastric surgery, any anterior mediastinal abnormality detected on preoperative imaging, ASA grade III/IV and poor preoperative pulmonary function were excluded.
  • RESULTS: Of the 49 patients (34 men), 24 patients were randomized to the anterior mediastinal route and 25 to the posterior.
  • The mean duration of the operative procedure (anterior: 235min; posterior: 225min) and the mean blood loss (anterior: 531ml; posterior: 538ml) were not statistically different.
  • [MeSH-major] Carcinoma / surgery. Esophageal Neoplasms / surgery. Esophagectomy / methods
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Follow-Up Studies. Humans. Male. Mediastinum / surgery. Middle Aged. Postoperative Complications. Prospective Studies. Treatment Outcome

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  • (PMID = 19577967.001).
  • [ISSN] 1878-3562
  • [Journal-full-title] Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
  • [ISO-abbreviation] Dig Liver Dis
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] Netherlands
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78. Yakushiji S, Tateishi U, Nagai S, Matsuno Y, Nakagawa K, Asamura H, Kusumoto M: Computed tomographic findings and prognosis in thymic epithelial tumor patients. J Comput Assist Tomogr; 2008 Sep-Oct;32(5):799-805
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  • On multiple regression analysis, vascular obliteration and a blunt sternum-anterior mediastinum angle were more frequent with thymic carcinoma than with thymoma.
  • On multivariate analysis, pleural effusion and mediastinal fat infiltration on initial computed tomography had a significant impact on survival.
  • CONCLUSIONS: Vascular obliteration and a blunt sternum-anterior mediastinum angle were predictive of thymic carcinoma.
  • Pleural effusion and mediastinal fat infiltration were predictive of a poor prognosis.
  • [MeSH-major] Carcinoma / mortality. Carcinoma / radiography. Thymus Neoplasms / mortality. Thymus Neoplasms / radiography. Tomography, X-Ray Computed
  • [MeSH-minor] Adipose Tissue / radiography. Adult. Aged. Aged, 80 and over. Female. Humans. Male. Mediastinum / radiography. Middle Aged. Pleural Effusion, Malignant / radiography. Prognosis. Retrospective Studies. Sternum / radiography

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  • (PMID = 18830115.001).
  • [ISSN] 1532-3145
  • [Journal-full-title] Journal of computer assisted tomography
  • [ISO-abbreviation] J Comput Assist Tomogr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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79. Kaira K, Watanabe R, Takise A, Endou K, Kamiyoshihara M, Mori M: [Thymic cancer effectively treated by combination chemotherapy of carboplatin and etoposide with concurrent radiotherapy]. Gan To Kagaku Ryoho; 2005 Nov;32(12):1989-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A chest CT scan revealed a large anterior mediastinal mass and pericardial effusion.
  • Percutaneous needle biopsy showed that the mass was an advanced thymic cancer (squamous cell carcinoma).
  • This concurrent chemoradiotherapy can be effective against inoperable squamous cell carcinoma of the thymus.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Squamous Cell / drug therapy. Carcinoma, Squamous Cell / radiotherapy. Thymus Neoplasms / drug therapy. Thymus Neoplasms / radiotherapy

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  • (PMID = 16282742.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 6PLQ3CP4P3 / Etoposide; BG3F62OND5 / Carboplatin
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80. Nishi T, Takamori S, Muta F, Yoshiyama K, Iwasaki Y, Shirouzu K: Nonmalignant pericardial effusion associated with thymic cancer. Gen Thorac Cardiovasc Surg; 2010 May;58(5):239-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We report a case of thymic carcinoma with massive pericardial effusion in a 74-year-old man.
  • A chest computed tomography and magnetic resonance imaging showed an anterior mediastinal mass measuring 8.0 x 5.0 cm with massive pericardial effusion.
  • The mass lesion was suggestive of thymic carcinoma or invasive thymoma.
  • Histopathological findings confirmed the lesion to be squamous cell carcinoma of the thymus.
  • The etiology of a massive nonmalignant pericardial effusion associated with thymic carcinoma warrants further studies.
  • [MeSH-major] Carcinoma, Squamous Cell / complications. Pericardial Effusion / etiology. Thymoma / complications. Thymus Neoplasms / complications

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  • (PMID = 20449715.001).
  • [ISSN] 1863-6713
  • [Journal-full-title] General thoracic and cardiovascular surgery
  • [ISO-abbreviation] Gen Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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81. Shirahama T, Ashitani J, Kodama T, Kyoraku Y, Sano A, Matsumoto N, Yonekawa T, Nakazato M: [A case of lung cancer with hyperthyroidism]. Nihon Kokyuki Gakkai Zasshi; 2008 Apr;46(4):308-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • On presentation, this patient showed painful anterior cervical swelling and right supraclavicular lymph node swelling.
  • Although subacute thyroiditis was suspected, echo-guided needle aspiration biopsy and lymph node biopsy revealed poorly differentiated squamous cell carcinoma.
  • As a result, primary lung cancer with thyroid metastasis was diagnosed based on mediastinal enlargement on chest X ray films and normal findings in organs other than the lung and thyroid.
  • Postmortem revealed that the right upper lung carcinoma was the primary lesion and immunohistochemical staining for surfactant protein was positive in the thyroid, skin tumor and lymph node, which revealed these carcinomas had metastasized from lung cancer.
  • [MeSH-major] Carcinoma, Squamous Cell / complications. Hyperthyroidism / etiology. Lung Neoplasms / complications

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  • (PMID = 18516995.001).
  • [ISSN] 1343-3490
  • [Journal-full-title] Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
  • [ISO-abbreviation] Nihon Kokyuki Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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82. Nakagawa K, Matsuno Y, Kunitoh H, Maeshima A, Asamura H, Tsuchiya R: Immunohistochemical KIT (CD117) expression in thymic epithelial tumors. Chest; 2005 Jul;128(1):140-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • STUDY OBJECTIVES: It is sometimes very difficult both clinically and pathologically to distinguish thymic epithelial tumors from primary lung carcinoma with massive anterior mediastinal involvement.
  • The expression of KIT (CD117) in thymic epithelial tumors was investigated in order to evaluate its usefulness as a marker supporting differential diagnosis and choice of therapy.
  • We also compared the expression of KIT and CD5 in 20 thymic carcinomas with their expression in 20 resected pulmonary squamous cell carcinomas that were spreading directly into the mediastinum.
  • Furthermore, of the 40 specimens examined (either thymic or lung carcinoma) all 13 that were positive for both KIT and CD5 were thymic carcinomas, and 13 of the 16 that were negative for both were lung carcinomas.
  • CONCLUSION: KIT expression is a useful immunohistochemical marker for the diagnosis of thymic carcinoma, and its examination in combination with CD5 immunohistochemistry would greatly help in the differential diagnosis of primary thymic carcinoma from pulmonary squamous cell carcinoma.
  • [MeSH-major] Carcinoma / metabolism. Proto-Oncogene Proteins c-kit / biosynthesis. Thymoma / metabolism. Thymus Neoplasms / metabolism
  • [MeSH-minor] Biomarkers, Tumor / analysis. Carcinoma, Squamous Cell / metabolism. Diagnosis, Differential. Humans. Immunohistochemistry

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  • (PMID = 16002927.001).
  • [ISSN] 0012-3692
  • [Journal-full-title] Chest
  • [ISO-abbreviation] Chest
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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83. Maldjian PD, Ghesani N: Focal increased activity in the liver on 18F-FDG PET scan secondary to brachiocephalic vein and superior vena cava obstruction. J Thorac Imaging; 2008 Nov;23(4):275-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Collateral venous pathways from anterior chest wall veins to the portal veins can form via paraumbilical veins (including the vein of Burrow and the superior and inferior veins of Sappey) or subcapsular veins of the liver via musculophrenic vessels.
  • [MeSH-major] Brachiocephalic Veins / pathology. Brachiocephalic Veins / radiography. Carcinoma, Non-Small-Cell Lung / secondary. Liver / radionuclide imaging. Lung Neoplasms / pathology. Mediastinal Neoplasms / radiography. Mediastinal Neoplasms / radionuclide imaging. Positron-Emission Tomography. Superior Vena Cava Syndrome / pathology. Superior Vena Cava Syndrome / radiography

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  • (PMID = 19204474.001).
  • [ISSN] 1536-0237
  • [Journal-full-title] Journal of thoracic imaging
  • [ISO-abbreviation] J Thorac Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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84. Eren S, Karaman A, Okur A: The superior vena cava syndrome caused by malignant disease. Imaging with multi-detector row CT. Eur J Radiol; 2006 Jul;59(1):93-103
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  • MATERIALS AND METHODS: We present CT angiography findings of seven patients with small cell carcinoma of the lung (n = 2), squamous cell carcinoma of the lung (n = 3), Hodgkin disease of the thorax (n = 1), and squamous cell carcinoma of the oesophagus (n = 1).
  • The most common experienced collateral vessels were azygos vein (6), intercostal veins (6), mediastinal veins (6), paravertebral veins (5), hemiazygos vein (5), thoracoepigastric vein (5), internal mammary vein (5), thoracoacromioclavicular venous plexus (5), and anterior chest wall veins (5).
  • [MeSH-minor] Adult. Aged. Carcinoma, Small Cell / complications. Carcinoma, Small Cell / radiography. Carcinoma, Squamous Cell / complications. Carcinoma, Squamous Cell / radiography. Esophageal Neoplasms / complications. Esophageal Neoplasms / radiography. Female. Hodgkin Disease / complications. Hodgkin Disease / radiography. Humans. Lung Neoplasms / complications. Lung Neoplasms / radiography. Male. Middle Aged

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  • (PMID = 16476534.001).
  • [ISSN] 0720-048X
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
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85. Yu H, Zhang SY, Wang X, Xie ZM, Wang JY, Li Y, Xie X, Zhou JL, Zhang LJ, Fu JH: [Evaluation of scalene lymph node or contralateral mediastinum biopsy during mediastinoscopy for non-small cell lung cancer]. Zhonghua Zhong Liu Za Zhi; 2009 Oct;31(10):780-2
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  • [Title] [Evaluation of scalene lymph node or contralateral mediastinum biopsy during mediastinoscopy for non-small cell lung cancer].
  • Of those, 12 underwent cervical medistinoscopy combined with right scalene lymph node biopsy and 10 with anterior mediastinotomy.
  • Of those, 6 had contralateral mediastinal lymph node metastasis and 3 cases with right scalene lymph node metastasis.
  • The incidence of N3 disease in the patients with adenocarcinoma, serum CEA > 5 ng/ml and multi-station mediastinal lymph node metastasis was significantly higher than that in those with non-adenocarcinoma, CEA < 5 ng/ml and ipsilateral uni-station mediastinal lymph nodes metastasis (P < 0.05).
  • CONCLUSION: Biopsy of scalene lymph node or contralateral mediastinal lymph node should be performed during mediastinoscopy in order to exclude N3 disease for potentially operable NSCLC patients with adenocarcinoma, serum CEA >5 ng/ml and ipsilateral multi-station mediastinal lymph nodes metastasis.
  • [MeSH-major] Adenocarcinoma / pathology. Carcinoma, Non-Small-Cell Lung / pathology. Lung Neoplasms / pathology. Lymph Nodes / pathology
  • [MeSH-minor] Adult. Aged. Biopsy. Carcinoembryonic Antigen / blood. Female. Follow-Up Studies. Humans. Lymphatic Metastasis. Male. Mediastinoscopy. Mediastinum. Middle Aged. Neck Muscles. Neoplasm Staging

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  • (PMID = 20021834.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen
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86. Batori M, Chatelou E, Straniero A, Mariotta G, Palombi L, Pastore P, Casella G, Casella MC: Substernal goiters. Eur Rev Med Pharmacol Sci; 2005 Nov-Dec;9(6):355-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: The surgical technique foresees always an anterior collar neck incision.
  • As for what concerns the results of the histological examination, in 2/45 (4.5%) cases it has been set a diagnosis of follicular carcinoma (one of them surely invading and the other, leastly invading), in 3/45 (6.6%) cases papillary carcinoma, in 4/45 (8.8%) cases colloido-cystic goiter, in 33/45 (73.5%) cases micro-macrofollicular hyperplasia (in one of which contemporarily compromise from lymphoma of Hodgkin); in 3/45 (6.6%) cases of adenomatous hyperplasia of the thyroid.
  • After the intervention, in all the patients the symptomatology tied to the mediastinal compression has disappeared.
  • The goiter showed signs of neoplastic degeneration in 11.1% of the cases, with prevalence of the papillary carcinoma in the 6.6% and, in the remaining 4.5%, of follicular carcinoma.
  • [MeSH-minor] Adenocarcinoma, Follicular / diagnosis. Adenocarcinoma, Follicular / surgery. Adult. Aged. Carcinoma, Papillary / diagnosis. Carcinoma, Papillary / surgery. Elective Surgical Procedures / methods. Elective Surgical Procedures / standards. Female. Humans. Italy / epidemiology. Male. Middle Aged. Risk Factors. Thyroid Neoplasms / diagnosis. Thyroid Neoplasms / surgery. Thyroidectomy / methods. Thyroidectomy / statistics & numerical data. Time Factors

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  • (PMID = 16479740.001).
  • [ISSN] 1128-3602
  • [Journal-full-title] European review for medical and pharmacological sciences
  • [ISO-abbreviation] Eur Rev Med Pharmacol Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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87. Morikawa H, Tanaka T, Hamaji M, Ueno Y, Hara A: Papillary adenocarcinoma developed in a thymic cyst. Gen Thorac Cardiovasc Surg; 2010 Jun;58(6):295-7
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  • In this report, we describe a case of a thymic carcinoma that developed in a thymic cyst, which was resected by video-assisted thoracic surgery (VATS).
  • Chest computed tomography demonstrated a well-confined cystic mass that measured 4 cm in diameter occupying the anterior mediastinum.
  • On the basis of this diagnosis, we performed multidrug adjuvant chemotherapy.
  • [MeSH-major] Adenocarcinoma, Papillary / pathology. Mediastinal Cyst / pathology. Thymus Neoplasms / pathology

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  • (PMID = 20549461.001).
  • [ISSN] 1863-6713
  • [Journal-full-title] General thoracic and cardiovascular surgery
  • [ISO-abbreviation] Gen Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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88. Gomez M, Silvestri GA: Endobronchial ultrasound for the diagnosis and staging of lung cancer. Proc Am Thorac Soc; 2009 Apr 15;6(2):180-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Endobronchial ultrasound for the diagnosis and staging of lung cancer.
  • The diagnosis of indeterminate mediastinal lymph nodes, masses, and peripheral pulmonary nodules constitutes a significant challenge.
  • Options for tissue diagnoses include computed tomography-guided percutaneous biopsy, transbronchial fine-needle aspiration, mediastinoscopy, left anterior mediastinotomy, or video-assisted thoracoscopic surgery; however, these approaches have both advantages and limitations in terms of tissue yield, safety profile, and cost.
  • The radial probe EBUS allows for evaluation of central airways, accurate definition of airway invasion, and facilitates the diagnosis of peripheral lung lesions.
  • Linear EBUS guides transbronchial needle aspiration of hilar and mediastinal lymph nodes, improving diagnostic yield.
  • This article will review the principles and clinical applications of EBUS, and will highlight the role of this new technology in the diagnosis and staging of lung cancer.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / ultrasonography. Endosonography / methods. Lung Neoplasms / ultrasonography

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  • (PMID = 19349486.001).
  • [ISSN] 1546-3222
  • [Journal-full-title] Proceedings of the American Thoracic Society
  • [ISO-abbreviation] Proc Am Thorac Soc
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 63
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89. Jung SM, Chu PH, Shiu TF, Wu HH, Kuo TT, Chu JJ, Lin PJ: Expression of OCT4 in the primary germ cell tumors and thymoma in the mediastinum. Appl Immunohistochem Mol Morphol; 2006 Sep;14(3):273-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of OCT4 in the primary germ cell tumors and thymoma in the mediastinum.
  • Primary germ cell tumors (GCTs) and thymoma are both located in the anterior mediastinum.
  • This study examined OCT4 expression in GCTs and thymoma originating from the mediastinum.
  • A retrospective study included 46 consecutive patients with GCTs conducted between 1983 and 2005, and 22 consecutive thymoma in the mediastinum whose tumors had been surgically excised.
  • The 46 primary GCTs in mediastinum included teratoma (n=27; 58.7%), seminoma (n=10; 21.7%), yolk sac tumor (n=6; 13%), embryonal carcinoma (n=1; 2.1%), and mixed GCTs (n=2; 4%; one consisted of teratoma and yolk sac tumor, and the other teratoma, yolk sac tumor, and seminoma); and 22 thymoma including World Health Organization type A (n=3, 13.6%), type AB (n=4, 18.2%), type B1 (n=6, 27.3%), type B2 (n=4, 13.6%), and type B3 (n=5, 22.7%).
  • All 10 seminoma cases, 1 embryonal carcinoma case, and 1 mixed GCT case containing seminoma were immunopositive for OCT4.
  • We conclude that immunostaining with antibodies to OCT4 is a useful diagnostic tool in the identification of seminomas and primary embryonal carcinomas in GCTs originating from the mediastinum.

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  • (PMID = 16932017.001).
  • [ISSN] 1541-2016
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Congresses; Evaluation Studies; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Biomarkers, Tumor; 0 / OKT4A monoclonal antibody
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90. Cheney RT: The biologic spectrum of thymic epithelial neoplasms: current status and future prospects. J Natl Compr Canc Netw; 2010 Nov;8(11):1322-8
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  • Thymoma is the most common anterior mediastinal tumor in adults and is frequently associated with autoimmune disorders such as myasthenia gravis.
  • This article discusses thymic organogenesis, Masaoka staging, WHO histologic classification of thymoma and thymic carcinoma, and selected molecular characteristics that highlight this diversity.

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  • (PMID = 21081787.001).
  • [ISSN] 1540-1405
  • [Journal-full-title] Journal of the National Comprehensive Cancer Network : JNCCN
  • [ISO-abbreviation] J Natl Compr Canc Netw
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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91. Hinterthaner M, Stamatis G: [Role of mediastinoscopy and repeat mediastinoscopy today]. Chirurg; 2008 Jan;79(1):38, 40-4
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  • For patients with lung cancer preoperative evaluation of the mediastinal lymph nodes is important to estimate local operability and/or to consider the necessity of neoadjuvant treatment.
  • Additionally extended CM and left parasternal mediastinotomy allow the exploration of the aortopulmonary window (level 5) and anterior mediastinal nodes (level 6).
  • In locally advanced lung cancer repeat mediastinoscopy was used after induction chemotherapy or chemoradiation to reexplore the upper mediastinum in order to select patients with a higher probability to undergo complete resection.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / pathology. Lung Neoplasms / pathology. Lymphatic Metastasis / diagnosis. Mediastinoscopy. Neoplasm Staging / methods

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  • (PMID = 18209980.001).
  • [ISSN] 0009-4722
  • [Journal-full-title] Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen
  • [ISO-abbreviation] Chirurg
  • [Language] ger
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
  • [Number-of-references] 35
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92. Eloubeidi MA, Tamhane A, Chen VK, Cerfolio RJ: Endoscopic ultrasound-guided fine-needle aspiration in patients with non-small cell lung cancer and prior negative mediastinoscopy. Ann Thorac Surg; 2005 Oct;80(4):1231-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We assessed (1) the yield of EUS-FNA of malignant lymph nodes in NSCLC patients with combined anterior and posterior lymph nodes that had already undergone mediastinoscopy and (2) the cost implications associated with alternative initial strategies.
  • Then, the posterior mediastinal stations (7, 8, and 9) or station 5 were targeted with EUS-FNA.
  • CONCLUSIONS: In patients with NSCLC and combined anterior and posterior lymph nodes, starting with EUS-FNA would preclude mediastinoscopy in more than one third of the patients.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / pathology. Carcinoma, Non-Small-Cell Lung / surgery. Lung Neoplasms / pathology. Lung Neoplasms / surgery. Neoplasm Staging / methods


93. Shalini CS, Joseph LD, Abraham G, Prathiba D, Rajendiran S: Cytologic features of pulmonary blastoma. J Cytol; 2009 Apr;26(2):74-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A preoperative diagnosis of pulmonary blastoma is difficult to obtain by cytopathologic methods.
  • A diagnosis of biphasic pulmonary blastoma should be considered when there is a dimorphic population of cells on cytology.
  • Chest radiograph and computed tomography of thorax revealed an anterior mediastinal mass that was subjected to ultrasound-guided fine-needle aspiration cytology.
  • The possibility of a non-small cell carcinoma was suggested.

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  • (PMID = 21938157.001).
  • [ISSN] 0970-9371
  • [Journal-full-title] Journal of cytology
  • [ISO-abbreviation] J Cytol
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3168023
  • [Keywords] NOTNLM ; Cytology / pulmonary blastoma / vertebral secondaries
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94. Somers GR, Smith CR, Perrin DG, Wilson GJ, Taylor GP: Sudden unexpected death in infancy and childhood due to undiagnosed neoplasia: an autopsy study. Am J Forensic Med Pathol; 2006 Mar;27(1):64-9
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  • Diagnoses included 2 cases of acute leukemia (1 myelogenous, 1 lymphoblastic), 2 cases of mediastinal lymphoblastic lymphoma (pre-T cell type), 1 papillary fibroelastoma of the mitral valve prolapsing into and totally occluding the left anterior descending coronary artery, 1 medulloblastoma, 1 Wilms tumor associated with fatal intraperitoneal hemorrhage, and 1 widely disseminated gastric carcinoma.

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  • (PMID = 16501353.001).
  • [ISSN] 0195-7910
  • [Journal-full-title] The American journal of forensic medicine and pathology
  • [ISO-abbreviation] Am J Forensic Med Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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95. Takashima S, Nakano H, Misao T: [True thymic hyperplasia which was difficult to distinguish from malignancy in adult; report of a case]. Kyobu Geka; 2008 Jul;61(7):599-601
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Three years earlier he had undergone operation for carcinoma of the floor of mouth.
  • He had no symptoms but had been pointed out an anterior mediastinal mass on chest computed tomography (CT).
  • [MeSH-major] Thymus Gland / pathology. Thymus Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Humans. Hyperplasia. Male. Middle Aged

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  • (PMID = 18616111.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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96. Patel KJ, Latif SU, de Calaca WM: An unusual presentation of precursor T cell lymphoblastic leukemia/lymphoma with cholestatic jaundice: case report. J Hematol Oncol; 2009;2:12
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  • Chest x-ray revealed a mediastinal mass with mediastinal widening.
  • CT scan of the chest showed anterior mediastinal mass (16 cm x 10 cm).
  • PET CT scan again showed a large anterior mediastinal mass with diffuse liver involvement and abnormal activity in axial bones.
  • Thus, the diagnosis of precursor T-ALL/T-LBL was made and jaundice with elevated CA 19-9 were attributed to intrahepatic cholestasis.
  • Tissue biopsy with thorough immunohistochemistry is required to differentiate precursor T-ALL/T-LBL from thymoma and small cell carcinoma.
  • [MeSH-major] Jaundice, Obstructive / diagnosis. Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male. Obesity / complications. Synaptophysin / metabolism

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  • (PMID = 19284608.001).
  • [ISSN] 1756-8722
  • [Journal-full-title] Journal of hematology & oncology
  • [ISO-abbreviation] J Hematol Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Synaptophysin
  • [Other-IDs] NLM/ PMC2663564
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97. Braun U, Grest P, Jehle W, Kaps S, Spiess B: [Intraocular hemorrhage in a goat with thrombocytopenia and metastasis of an adenocarcinoma in the iris]. Schweiz Arch Tierheilkd; 2008 Jul;150(7):359-62
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  • Approximately 75 per cent of the anterior chamber was filled with non-coagulated blood.
  • The fluid in the anterior chamber dorsal to the blood was cloudy, and the corpora nigra could not be seen clearly.
  • Ultrasonography of the left eye confirmed cloudiness of the anterior chamber and revealed moderate thickening of the iris.
  • Based on immunohistochemical evaluation of the cells metastasis of a carcinoma was diagnosed.
  • The anterior chamber of the left eye contained blood, and the iris was thicker than normal and adhered to the posterior surface of the cornea.
  • There were neoplastic alterations in the iris, the oesophagus, the lung lobes, the liver, the kidney and in the prescapular, retropharyngeal, mediastinal and hepatic lymph nodes.
  • Histologically, a diagnosis of carcinoma was confirmed, but the origin of the tumour could not be determined.
  • [MeSH-major] Adenocarcinoma / veterinary. Eye Hemorrhage / veterinary. Goat Diseases / diagnosis. Iris Neoplasms / veterinary

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  • (PMID = 18714940.001).
  • [ISSN] 0036-7281
  • [Journal-full-title] Schweizer Archiv für Tierheilkunde
  • [ISO-abbreviation] Schweiz. Arch. Tierheilkd.
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Switzerland
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98. Kumar A, Regmi SK, Dutta R, Kumar R, Gupta SD, Das P, Halanaik D, Jindal T: Characterization of thymic masses using (18)F-FDG PET-CT. Ann Nucl Med; 2009 Aug;23(6):569-77

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: The resectability and survival may be improved in thymoma and thymic carcinoma with multimodality therapy.
  • Various diagnostic imaging modalities are required for accurate diagnosis and preoperative staging of thymic masses.
  • METHODS: A prospective study was undertaken in 23 patients who had shown either an anterior mediastinal mass consistent with thymic origin or suspicious for a thymic mass on contrast-enhanced computed tomography scan.
  • The difference between the mean SUVmax for thymic hyperplasia, thymoma and thymic carcinoma was statistically significant.
  • [MeSH-minor] Adolescent. Adult. Biopsy. Humans. Male. Mediastinum / pathology. Middle Aged. Positron-Emission Tomography. Prospective Studies. Tomography, X-Ray Computed. Young Adult

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  • (PMID = 19585212.001).
  • [ISSN] 1864-6433
  • [Journal-full-title] Annals of nuclear medicine
  • [ISO-abbreviation] Ann Nucl Med
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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99. Maniwa T, Saito Y, Saito T, Kaneda H, Imamura H: Evaluation of chest computed tomography in patients after pneumonectomy to predict contralateral pneumothorax. Gen Thorac Cardiovasc Surg; 2009 Jan;57(1):28-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We evaluated the mediastinal shift and the residual lung in patients who had undergone pneumonectomy to predict the incidence of contralateral pneumothorax.
  • When evaluating the degree of herniation 4-6 cm below the carina, the anterior and posterior pulmonary hernias were classified as grade A, B, or C.
  • Lung herniation and mediastinal shift are greater after left pneumonectomy than after right pneumonectomy, which may be related to contralateral pneumothorax after pneumonectomy.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / surgery. Lung Neoplasms / surgery. Pneumonectomy / adverse effects. Pneumothorax / radiography. Tomography, X-Ray Computed

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  • (PMID = 19160008.001).
  • [ISSN] 1863-6705
  • [Journal-full-title] General thoracic and cardiovascular surgery
  • [ISO-abbreviation] Gen Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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100. Iwazaki M, Inoue H: Microthoracoscopic one-port method for lung cancer. Ann Thorac Surg; 2009 Apr;87(4):1250-2
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  • DESCRIPTION: The subjects were the 40 patients in whom ND2 lymph node dissection was performed among those with a preoperative diagnosis of stage IA (T1 N0 M0) lung cancer who underwent thoracoscopic operations in our hospital during the 2-year period from January 2001 to December 2002.
  • With the patient in the lateral position, a Thoraco Holder (Fuji Systems Corp, Tokyo, Japan) was inserted between the fourth and fifth intercostal space on the anterior axillary line.
  • Pulmonary lobectomy and mediastinal dissection were performed in the same manner as the standard thoracoscopic two-windows method.
  • [MeSH-major] Adenocarcinoma / surgery. Carcinoma, Squamous Cell / surgery. Lung Neoplasms / surgery. Thoracoscopy / methods

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  • [CommentIn] Ann Thorac Surg. 2009 Dec;88(6):2069 [19932305.001]
  • (PMID = 19324160.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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