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1. Lee YJ, Kang SM, Kang IB: Acute angle-closure glaucoma from spontaneous massive hemorrhagic retinal detachment. Korean J Ophthalmol; 2007 Mar;21(1):61-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Acute angle-closure glaucoma from spontaneous massive hemorrhagic retinal detachment.
  • PURPOSE: To report a case of acute angle-closure glaucoma resulting from spontaneous hemorrhagic retinal detachment.
  • The left anterior chamber depth was shallow and gonioscopy of the left eye showed a closed angle.
  • In comparison, the right anterior chamber depth was normal and showed a wide, open angle.
  • After systemic and topical antiglaucoma medications failed to relieve her intractable severe ocular pain, she underwent enucleation.
  • RESULTS: The ocular pathology specimen showed that a large subretinal hemorrhage caused retinal detachment and pushed displaced the lens-iris diaphragm, resulting in secondary angle-closure glaucoma.
  • CONCLUSIONS: Prolonged anticoagulant therapy may cause hemorrhagic retinal detachment and secondary angle-closure glaucoma.
  • If medical therapy fails to relieve pain or if there is suspicion of an intraocular tumor, enucleation should be considered as a therapeutic option.
  • [MeSH-major] Glaucoma, Angle-Closure / etiology. Retinal Detachment / etiology. Retinal Hemorrhage / complications


2. Longmuir SQ, Syed NA, Boldt HC: Diffuse anterior retinoblastoma without retinal involvement. Ophthalmology; 2010 Oct;117(10):2034-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diffuse anterior retinoblastoma without retinal involvement.
  • PURPOSE: To present a unique case of an 8.5-year-old child with unilateral, anterior, pseudouveitis.
  • He was found to have unilateral, invasive, small blue cell tumor of the anterior segment that was diagnosed as diffuse infiltrating retinoblastoma despite lack of retinal involvement on fundus examination or histopathologic analysis.
  • INTERVENTION: The patient was treated with topical prednisolone acetate 1% and oral prednisone with no improvement in anterior chamber reaction.
  • The patient underwent fine-needle aspiration biopsy (FNAB) of anterior chamber fluid, the results of which were consistent with a primitive neuroectodermal neoplasm, either retinoblastoma or medulloepithelioma.
  • MAIN OUTCOME MEASURES: The patient is alive and tumor free with follow-up of 5 years.
  • RESULTS: Microscopic examination demonstrated cells similar to those seen on the FNAB infiltrating the iris stroma, trabecular meshwork, Schlemm's canal, and the inner portion of sclera in the region of the angle.
  • Serial sections of the entire globe were performed to determine the origin of the tumor.
  • No retinal involvement was identified, and tumor was not seen to arise from the ciliary epithelium.
  • CONCLUSIONS: This patient represents a case of diffuse anterior retinoblastoma with lack of obvious retinal involvement.
  • Although the patient lacked a retinal focus, he is alive at 5 years without evidence of recurrence of tumor.
  • [MeSH-major] Anterior Eye Segment / pathology. Retinal Neoplasms / pathology. Retinoblastoma / pathology
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biopsy, Needle. Child. Combined Modality Therapy. Eye Enucleation. Humans. Male. Neoplasm Invasiveness. Orbit / drug effects. Orbit / radiation effects. Retrospective Studies. Uveitis, Anterior / complications


3. Guzek WJ, Sułkowski WJ, Kowalska S, Makowska Z: [Tinnitus Center at the Nofer Institute of Occupational Medicine--earliest experience]. Med Pr; 2002;53(6):461-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Tinnitus Center at the Nofer Institute of Occupational Medicine--earliest experience].
  • Of the 150 patients admitted in 2001 to the Tinnitus Center located at the Nofer Institute of Occupational Medicine, Łódź, Poland, 80 were subjected to complex examinations consisted of standardized questionnaire on medical history, psychological tests and audiological assessment.
  • The diagnostic procedure was completed for 52 patients (23 females and 29 males; mean age: 53 years).
  • In neither of cases did this diagnosis confirm the suspected tumor development (n.
  • VIII neurinoma or pontocerebral angle tumor.
  • 4. The negative diagnostics for tumor within the cranial cavity has not only a soothing effect on the patient as it relieves his/her stress, but it can also be a good starting point for the tinnitus retraining therapy.

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  • (PMID = 12701536.001).
  • [ISSN] 0465-5893
  • [Journal-full-title] Medycyna pracy
  • [ISO-abbreviation] Med Pr
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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4. Ardjomand N, Komericki P, Langmann G, Mattes D, Moray M, Scarpatetti M, El-Shabrawi Y: Lymph node metastases arising from uveal melanoma. Wien Klin Wochenschr; 2005 Jun;117(11-12):433-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Pigment dispersion glaucoma was diagnosed and since the intraocular pressure could not be managed with topical medication, transscleral cyclophotocoagulation and two trabeculectomies had to be performed.
  • Due to enlargement of the pigmented iris mass and cell deposits in the chamber angle, a ciliary body ring melanoma was presumed and the eye enucleated.
  • Tumor seeding through the trabeculectomy site into the bleb and then via conjunctival lymphatic vessels might be the crucial factor for this pathway of metastases.
  • [MeSH-major] Ciliary Body / pathology. Glaucoma, Open-Angle / surgery. Light Coagulation. Lymphatic Metastasis / pathology. Melanoma / pathology. Postoperative Complications / pathology. Trabeculectomy. Uveal Neoplasms / pathology
  • [MeSH-minor] Adult. Anterior Chamber / pathology. Eye Enucleation. Female. Follow-Up Studies. Humans. Iris / pathology. Lymph Nodes / pathology. Microscopy. Neck. Neoplasm Invasiveness / pathology. Ophthalmoscopy. Reoperation. Trabecular Meshwork / pathology


5. Demirci H, Shields CL, Shields JA, Eagle RC Jr, Honavar S: Ring melanoma of the anterior chamber angle: a report of fourteen cases. Am J Ophthalmol; 2001 Sep;132(3):336-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ring melanoma of the anterior chamber angle: a report of fourteen cases.
  • PURPOSE: Ring melanoma of the anterior chamber angle is a rare variant of uveal melanoma that manifests as circumferential, flat tumor growth predominantly confined to the trabecular meshwork and other anterior chamber angle structures.
  • We report the clinical and histopathological features, management, and prognosis of ring melanoma of anterior chamber angle.
  • Of 8800 patients with uveal melanoma examined on the Oncology Service at Wills Eye Hospital over a 25-year period, only 14 patients (0.2%; 14 eyes) were classified clinically as ring melanoma of the anterior chamber angle.
  • Upon referral to the Oncology Service, the intraocular pressure was greater than 22 mm Hg in the affected eye in all patients (mean, 36 mm Hg; median, 35 mm Hg; range, 24 to 48 mm Hg), and all patients were using at least two glaucoma medications.
  • The melanoma infiltrated the anterior chamber angle for a mean of 10 clock hours (range, 8 to 12 clock hours).
  • Tumor management consisted of enucleation in 13 cases and plaque radiotherapy in one case.
  • Histopathologic examination revealed epithelioid cell type melanoma in one case, mixed cell type in nine, and spindle cell type in four.
  • Of the 13 patients who underwent enucleation, tumor cells were found within the Schlemm canal in all cases.
  • CONCLUSIONS: Ring melanoma of the trabecular meshwork and angle structures is a rare variant of diffuse uveal melanoma.
  • Despite the relatively small tumor volume, life prognosis is guarded with distant metastasis in 25% at mean 6 years follow-up.
  • [MeSH-major] Anterior Chamber / pathology. Melanoma / pathology. Uveal Neoplasms / pathology

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  • (PMID = 11530045.001).
  • [ISSN] 0002-9394
  • [Journal-full-title] American journal of ophthalmology
  • [ISO-abbreviation] Am. J. Ophthalmol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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