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1. Vecchio FM, Valentini V, Minsky BD, Padula GD, Venkatraman ES, Balducci M, Miccichè F, Ricci R, Morganti AG, Gambacorta MA, Maurizi F, Coco C: The relationship of pathologic tumor regression grade (TRG) and outcomes after preoperative therapy in rectal cancer. Int J Radiat Oncol Biol Phys; 2005 Jul 1;62(3):752-60
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  • [Title] The relationship of pathologic tumor regression grade (TRG) and outcomes after preoperative therapy in rectal cancer.
  • PURPOSE: To examine the relationship between tumor regression grade (TRG) and outcomes in patients with rectal cancer treated with preoperative therapy.
  • METHODS AND MATERIALS: Specimens from 144 patients with cT3,4 rectal cancer who had received preoperative radiation +/- chemotherapy and had a minimum follow-up of 3 years were retrospectively reviewed.
  • TRG, which involves examining the residual neoplastic cells and scoring the degree of both cytological changes, including nuclear pyknosis or necrosis and/or eosinophilia, as well as stromal changes, including fibrosis (either dense or edematous) with or without inflammatory infiltrate and giant-cell granulomatosis around ghost cells and keratin, was quantified in five grades according to the Mandard score (Cancer 1994;73:2680-2686).
  • By univariate analysis, none of the pretreatment factors examined, including age, circumference, length, distance from the anorectal ring, pretreatment T and N stage, and INDpre (defined as the pretreatment reference index size based on digital rectal examination), had an impact on 5-year outcomes, including local control, metastases-free survival, disease-free survival, and overall survival.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Analysis of Variance. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Combined Modality Therapy. Disease-Free Survival. Female. Humans. Male. Middle Aged. Neoplasm Staging. Neoplasm, Residual. Prognosis. Remission Induction. Retrospective Studies

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  • (PMID = 15936556.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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2. Summers RM, Swift JA, Dwyer AJ, Choi JR, Pickhardt PJ: Normalized distance along the colon centerline: a method for correlating polyp location on CT colonography and optical colonoscopy. AJR Am J Roentgenol; 2009 Nov;193(5):1296-304
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  • OBJECTIVE: The ability to accurately locate a polyp found on CT colonography (CTC) at subsequent optical colonoscopy (OC) is an important part of the successful implementation of CTC for colorectal cancer screening.
  • Each polyp's normalized distance along the colon centerline was computed by dividing its distance from the anorectal junction measured along the colon centerline by the length of the colon at CTC.
  • [MeSH-major] Colonic Polyps / diagnosis. Colonography, Computed Tomographic / methods. Colonoscopy / methods

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  • (PMID = 19843745.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z01 CL040003-05; United States / Intramural NIH HHS / / Z01 CL040003-06; United States / Intramural NIH HHS / / ZIA CL040003-07; United States / Intramural NIH HHS / / ZIA CL040003-08; United States / Intramural NIH HHS / / ZIA CL040003-09
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS394808; NLM/ PMC3415798
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3. Kroesen AJ, Gröne J, Buhr HJ, Ritz JP: [Therapy of refractory proctocolitis and Crohn's disease. Incisionless laparoscopic proctocolectomy with a Brooke ileostomy]. Chirurg; 2009 Aug;80(8):730-3
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  • All patients suffered from Crohn's pancolitis with anorectal fistulas.

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  • [CommentIn] Chirurg. 2009 Aug;80(8):734 [19669717.001]
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  • (PMID = 19533065.001).
  • [ISSN] 1433-0385
  • [Journal-full-title] Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen
  • [ISO-abbreviation] Chirurg
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 22
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4. Mandhan P, Quan QB, Beasley S, Sullivan M: Sonic hedgehog, BMP4, and Hox genes in the development of anorectal malformations in Ethylenethiourea-exposed fetal rats. J Pediatr Surg; 2006 Dec;41(12):2041-5
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  • [Title] Sonic hedgehog, BMP4, and Hox genes in the development of anorectal malformations in Ethylenethiourea-exposed fetal rats.
  • In this study, we investigated the expression of shh and its targets, BMP4 and Hox genes, in the development of anorectal malformations in Ethylenethiourea (ETU)-exposed embryos.

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  • (PMID = 17161201.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bmp4 protein, rat; 0 / Bone Morphogenetic Protein 4; 0 / Bone Morphogenetic Proteins; 0 / Hedgehog Proteins; 24FOJ4N18S / Ethylenethiourea
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5. Lee SH, Ahn BK, Chang HK, Baek SU: Adenocarcinoma in ileal pouch after proctocolectomy for familial adenomatous polyposis: report of a case. J Korean Med Sci; 2009 Oct;24(5):985-8
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  • Although the risk of cancer developing in an ileal pouch is not yet clear, a few cases of adenocarcinoma arising in an ileal pouch have been reported.
  • Six years later, she underwent completion-proctectomy with ileal J pouch-anal anastomosis including anorectal mucosectomy for rectal cancer.
  • The risk of cancer in an ileal pouch and its prevention with regular surveillance must be emphasized.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenomatous Polyposis Coli / surgery. Colonic Pouches / pathology. Colorectal Neoplasms / diagnosis. Proctocolectomy, Restorative

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  • (PMID = 19795007.001).
  • [ISSN] 1598-6357
  • [Journal-full-title] Journal of Korean medical science
  • [ISO-abbreviation] J. Korean Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2752792
  • [Keywords] NOTNLM ; Adenocarcinoma / Adenomatous Polyposis Coli / Ileal Pouches
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6. Khaniya S, Koirala R, Shakya VC, Adhikary S, Regmi R, Pandey SR, Agrawal CS: Anorectal tuberculosis coexisting with adenocarcinoma: an unusual association. Cases J; 2009;2:143
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  • [Title] Anorectal tuberculosis coexisting with adenocarcinoma: an unusual association.
  • INTRODUCTION: Tuberculosis affecting the anorectum is an uncommon extra-pulmonary form of the disease, and its association with malignancy is highly unusual.
  • With the diagnosis of carcinoma lower rectum, she underwent abdomino-perineal resection of the growth.
  • CONCLUSION: The aetiological association between the tuberculosis and anorectal cancer is a matter of debate.

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  • (PMID = 19292907.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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7. Stoidis CN, Spyropoulos BG, Misiakos EP, Fountzilas CK, Paraskeva PP, Fotiadis CI: Diffuse anorectal melanoma; review of the current diagnostic and treatment aspects based on a case report. World J Surg Oncol; 2009;7:64
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  • [Title] Diffuse anorectal melanoma; review of the current diagnostic and treatment aspects based on a case report.
  • Primary anorectal melanoma is a rare and aggressive disease.
  • [MeSH-major] Anus Neoplasms / diagnosis. Melanoma / diagnosis

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  • (PMID = 19671138.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2731760
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8. Stam H, Hartman EE, Deurloo JA, Groothoff J, Grootenhuis MA: Young adult patients with a history of pediatric disease: impact on course of life and transition into adulthood. J Adolesc Health; 2006 Jul;39(1):4-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: A total of 508 young adults from the general Dutch population and 650 patients, aged 18-30 years, participated: 348 survivors of childhood cancer, 93 patients with anorectal malformations, 72 patients with Hirschsprung's disease, 61 patients with oesophageal atresia, 76 patients with end-stage renal disease.
  • The course of life of young adults grown up with esophageal atresia was not delayed compared with that of their peers, whereas that of survivors of childhood cancer and patients with end-stage renal disease was delayed most.
  • Attention should especially be directed at children and adolescents growing up with childhood cancer or with end-stage renal disease.

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  • [CommentIn] J Adolesc Health. 2006 Jul;39(1):1-2 [16781953.001]
  • (PMID = 16781955.001).
  • [ISSN] 1879-1972
  • [Journal-full-title] The Journal of adolescent health : official publication of the Society for Adolescent Medicine
  • [ISO-abbreviation] J Adolesc Health
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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9. Brooks RA, Wright JD, Powell MA, Rader JS, Gao F, Mutch DG, Wall LL: Long-term assessment of bladder and bowel dysfunction after radical hysterectomy. Gynecol Oncol; 2009 Jul;114(1):75-9
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  • METHODS: Subjects included women who underwent radical hysterectomy for early stage cervical cancer between 1993 and 2003.
  • The Manchester Health Questionnaire and Fecal Incontinence Quality of Life Scale (FIQL) were used to assess anorectal symptoms.
  • CONCLUSION: Urinary incontinence is relatively common after radical hysterectomy, but severe anorectal dysfunction is uncommon.
  • Radical hysterectomy does not appear to be associated with more long-term bladder or anorectal dysfunction than simple hysterectomy.
  • [MeSH-minor] Adult. Emotions. Female. Humans. Life Style. Middle Aged. Neoplasm Staging. Retrospective Studies. Treatment Outcome. Urinary Incontinence / epidemiology. Urinary Incontinence / etiology


10. Ceelen W, Pattyn P, Boterberg T, Peeters M: Pre-operative combined modality therapy in the management of locally advanced rectal cancer. Eur J Surg Oncol; 2006 Apr;32(3):259-68
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  • [Title] Pre-operative combined modality therapy in the management of locally advanced rectal cancer.
  • AIMS: To review the use of pre-operative combined modality therapy (CMT, chemotherapy with radiotherapy) in the management of resectable rectal cancer.
  • METHODS: A systematic search was performed on pre-operative CMT and rectal cancer.
  • The scarce available data suggest that the addition of CT might worsen anorectal function compared to pre-operative RT alone.
  • CONCLUSIONS: Pre-operative CMT enhances tumour response and could therefore, have a role in patients with possibly invaded resection margins or low lying cancers, although both acute toxicity and anorectal function are worse compared to RT alone.
  • The final results of ongoing randomized trials will more accurately establish the role of pre-operative CMT in resectable rectal cancer patients.

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  • (PMID = 16443345.001).
  • [ISSN] 0748-7983
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 120
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11. Jiang JK, Yang SH, Lin JK: Transabdominal anastomosis after low anterior resection: A prospective, randomized, controlled trial comparing long-term results between side-to-end anastomosis and colonic J-pouch. Dis Colon Rectum; 2005 Nov;48(11):2100-8; discussion 2108-10
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  • METHODS: Fifty-six consecutive patients with middle-to-low rectal cancer undergoing low anterior resection were randomly assigned to side-to-end or colonic J-pouch group preoperatively.
  • Patients underwent functional evaluation, including anorectal manometry and functional assessment, preoperatively and then 3 months, 6 months, 1 year, and 2 years postoperatively.
  • CONCLUSIONS: Anastomosis after low anterior resection for middle to low rectal cancer could be performed safely from the abdomen.

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  • [ErratumIn] Dis Colon Rectum. 2006 Feb;49(2):287
  • (PMID = 16132480.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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12. Tezuka K, Inaba Y, Hayashi K, Miura T, Moriya T, Takiguchi M, Isobe H, Watabe S, Yanagawa N: [A case of liver metastasis from anorectal malignant melanoma on hemodialysis treated by chemotherapy]. Gan To Kagaku Ryoho; 2007 Oct;34(10):1709-12
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  • [Title] [A case of liver metastasis from anorectal malignant melanoma on hemodialysis treated by chemotherapy].
  • We report a case on hemodialysis with liver metastases from anorectal malignant melanoma treated by dacarbazine (DTIC).
  • An elastic soft mass was palpated in the anal canal, and a biopsy specimen was diagnosed as anorectal malignant melanoma histologically.
  • Subsequently, the patient died of respiratory failure 4 years after surgery, 1 year and 7 months after the diagnosis of multiple liver metastases.
  • We conclude that administration of DTIC undergoing hemodialysis for malignant melanoma with renal failure seems to be useful without severe adverse events.

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  • (PMID = 17940397.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 7GR28W0FJI / Dacarbazine
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13. Yeh JJ, Shia J, Hwu WJ, Busam KJ, Paty PB, Guillem JG, Coit DG, Wong WD, Weiser MR: The role of abdominoperineal resection as surgical therapy for anorectal melanoma. Ann Surg; 2006 Dec;244(6):1012-7
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  • [Title] The role of abdominoperineal resection as surgical therapy for anorectal melanoma.
  • OBJECTIVES:. 1) Characterize changes in the surgical treatment of anorectal melanoma over time.
  • SUMMARY BACKGROUND DATA: Although early data suggested improved survival in patients undergoing abdominoperineal resection (APR) for primary anorectal melanoma, such an aggressive approach may be unwarranted as distant relapse rates are high.
  • METHODS: A retrospective review was performed of all patients with anorectal melanoma treated at our institution between 1984 and 2003.
  • CONCLUSION: The extent of surgical treatment is not associated with outcome in primary anorectal melanoma.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Retrospective Studies. Survival Rate. Treatment Outcome

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  • (PMID = 17122627.001).
  • [ISSN] 0003-4932
  • [Journal-full-title] Annals of surgery
  • [ISO-abbreviation] Ann. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1856617
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14. Taweevisit M, Wisadeopas N, Phumsuk U, Thorner PS: Increased mast cell density in haemorrhoid venous blood vessels suggests a role in pathogenesis. Singapore Med J; 2008 Dec;49(12):977-9
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  • Although increased resting anorectal pressure is deemed to be a major initiating factor, a thorough understanding of the pathogenesis is still lacking.
  • METHODS: 48 cases of haemorrhoids were retrospectively collected at King Chulalongkorn Memorial Hospital, with normal anorectal tissue from surgically-removed colorectal cancer serving as controls.

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  • (PMID = 19122946.001).
  • [ISSN] 0037-5675
  • [Journal-full-title] Singapore medical journal
  • [ISO-abbreviation] Singapore Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Singapore
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15. Pucciani F, Ringressi MN, Redditi S, Masi A, Giani I: Rehabilitation of fecal incontinence after sphincter-saving surgery for rectal cancer: encouraging results. Dis Colon Rectum; 2008 Oct;51(10):1552-8
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  • [Title] Rehabilitation of fecal incontinence after sphincter-saving surgery for rectal cancer: encouraging results.
  • PURPOSE: Some patients, having undergone sphincter-saving operations for rectal cancer, may suffer from fecal incontinence.
  • After a preliminary clinical evaluation, including the Wexner Incontinence Scale score, anorectal manometry was performed.
  • At the end of program, all 88 patients were reassessed by means of a clinical evaluation and anorectal manometry; their results were compared with the clinical and manometric data from ten healthy control subjects.

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  • (PMID = 18452041.001).
  • [ISSN] 1530-0358
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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16. Stelzner F: [Autoregulatory growth control of adenomatous polyps and carcinogenesis in the colorectal region. Basics of tumor surgery Part I]. Chirurg; 2006 Nov;77(11):1048-55
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  • While colorectal adenomas have malignant potential, their transformation to cancerous lesions is exceedingly rare (e.g., in familial polyposis, or FAP, with a prevalence of only one in 10,000).
  • It has been hypothesized that "fully developed adenomas" frequently are a prestage of colorectal cancer.
  • The most prominent homing area for colorectal cancer is the rectum.
  • If the rectum is resected, metachronous cancer occurs only very rarely.
  • The most distal quarter of the rectum is cloacal in origin and a pivotal structure for anorectal continence.
  • [MeSH-minor] Adenomatous Polyposis Coli / genetics. Adenomatous Polyposis Coli / pathology. Adenomatous Polyposis Coli / surgery. Bone Marrow Cells / pathology. Cell Transformation, Neoplastic / genetics. Cell Transformation, Neoplastic / pathology. Chromosome Aberrations. Colon / pathology. Colon / surgery. Gene Expression Regulation, Neoplastic / physiology. Humans. Neoplasm Staging. Prognosis. Rectum / pathology. Rectum / surgery

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  • [CommentIn] Chirurg. 2006 Nov;77(11):1061-2 [17066270.001]
  • (PMID = 17068665.001).
  • [ISSN] 0009-4722
  • [Journal-full-title] Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen
  • [ISO-abbreviation] Chirurg
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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17. Zhou HT, Zhou ZX, Zhang HZ, Bi JJ, Zhao P: Wide local excision could be considered as the initial treatment of primary anorectal malignant melanoma. Chin Med J (Engl); 2010 Mar 5;123(5):585-8
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  • [Title] Wide local excision could be considered as the initial treatment of primary anorectal malignant melanoma.
  • BACKGROUND: Anorectal malignant melanoma was a rare disease with extremely poor prognosis.
  • The aim of this study was to explore the clinical characteristic, diagnosis and treatment strategies of anorectal malignant melanoma.
  • METHODS: The data of 57 patients with anorectal malignant melanoma was collected and retrospectively analyzed.
  • RESULTS: Rectal bleeding and anal mass were found to be common symptoms of anorectal malignant melanoma.
  • The preoperative diagnosis rate of anorectal malignant melanoma was 48.6%.
  • CONCLUSIONS: This study identified no survival advantage to abdominoperineal resection in treatment of anorectal malignant melanoma, and we propose that wide local excision could be considered as the initial treatment of choice.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Neoplasm Staging. Survival Rate

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  • (PMID = 20367986.001).
  • [ISSN] 0366-6999
  • [Journal-full-title] Chinese medical journal
  • [ISO-abbreviation] Chin. Med. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
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18. Freeman HJ, Perry T, Webber DL, Chang SD, Loh MY: Mucinous carcinoma in Crohn's disease originating in a fistulous tract. World J Gastrointest Oncol; 2010 Jul 15;2(7):307-10
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  • Malignant disease, including mucinous carcinomas of the colorectum, may complicate long-standing Crohn's disease.
  • An 18-year-old male with extensive small and large bowel involvement with Crohn's disease developed recurrent peri-rectal fistulous disease that persisted for more than a decade despite pharmacological and surgical therapy as well as later therapy with biological agents.
  • Although fistula cancer is rarely described in Crohn's disease, use of immunosuppressant and biological agents may play an initiating or exacerbating role in its development or progression.

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  • (PMID = 21160662.001).
  • [ISSN] 1948-5204
  • [Journal-full-title] World journal of gastrointestinal oncology
  • [ISO-abbreviation] World J Gastrointest Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2999135
  • [Keywords] NOTNLM ; Adalimumab / Anal fistula / Anorectal adenocarcinoma / Crohn’s disease / Fistula carcinoma / Infliximab / Tumor necrosis factor antibodies
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19. Lupattelli M, Mascioni F, Bellavita R, Draghini L, Tarducci R, Castagnoli P, Russo G, Aristei C: Long-term anorectal function after postoperative chemoradiotherapy in high-risk rectal cancer patients. Tumori; 2010 Jan-Feb;96(1):34-41
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  • [Title] Long-term anorectal function after postoperative chemoradiotherapy in high-risk rectal cancer patients.
  • AIMS AND BACKGROUND: After sphincter-preserving surgery for rectal cancer and postoperative radiochemotherapy, many patients have unsatisfactory anorectal functional results which are not considered by the most common toxicity scales.
  • The aim of the present study was to retrospectively assess the long-term incidence of impaired anorectal function in rectal cancer patients who underwent anterior resection and postoperative radiochemotherapy.
  • METHODS: Ninety-nine patients who underwent sphincter-saving surgery and postoperative radiochemotherapy for stage II-III rectal cancer from July 1991 to January 2002 were given a questionnaire on anorectal function.
  • Factors influencing anorectal function were examined.
  • CONCLUSIONS: Although retrospective, the present study included a large selected series that had undergone uniform adjuvant treatment and was followed for a median of 10 years.
  • Anorectal function assessment should enter routinely in clinical practice and should have importance in the therapeutic decisions.
  • [MeSH-minor] Activities of Daily Living. Adult. Aged. Anastomosis, Surgical. Chemotherapy, Adjuvant. Constriction, Pathologic. Defecation. Female. Flatulence. Humans. Male. Middle Aged. Neoadjuvant Therapy / methods. Neoplasm Staging. Quality of Life. Radiotherapy, Adjuvant. Retrospective Studies. Surveys and Questionnaires. Time Factors

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  • (PMID = 20437855.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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20. Miyamoto H, Nishioka M, Kurita N, Nakagawa T, Yoshikawa K, Higashijima J, Miyatani T, Shimada M: Usefulness of local excision for early lower rectal cancer. Hepatogastroenterology; 2007 Apr-May;54(75):736-9
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  • [Title] Usefulness of local excision for early lower rectal cancer.
  • BACKGROUND/AIMS: The purpose of this study was to examine the long-term results of transanal excision compared with major surgery for lower rectal cancer.
  • METHODOLOGY: This retrospective study included 14 patients with early rectal cancer within 8cm from the anal verge treated by local excision in the period from January 1991 to December 2000, and 16 patients treated by major surgery in the period from January 1996 to December 2000.
  • We evaluated the prognosis or anorectal or urinary function of these patients.
  • Anorectal and urinary function maintained a good status.
  • CONCLUSIONS: Local excision for early rectal cancer (Tis N0 M0) brought an excellent outcome, and maintained good anorectal and urinary function.
  • We recommend local excision for the early rectal cancer patients.
  • [MeSH-minor] Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Staging. Retrospective Studies. Treatment Outcome

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  • (PMID = 17591051.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
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21. Belli F, Gallino GF, Lo Vullo S, Mariani L, Poiasina E, Leo E: Melanoma of the anorectal region: the experience of the National Cancer Institute of Milano. Eur J Surg Oncol; 2009 Jul;35(7):757-62
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  • [Title] Melanoma of the anorectal region: the experience of the National Cancer Institute of Milano.
  • AIMS: This study describes the experience of the National Cancer Institute of Milano in the treatment of anorectal melanoma over the last 32 years.

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  • (PMID = 18602790.001).
  • [ISSN] 1532-2157
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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22. Guckenberger M, Pohl F, Baier K, Meyer J, Vordermark D, Flentje M: Adverse effect of a distended rectum in intensity-modulated radiotherapy (IMRT) treatment planning of prostate cancer. Radiother Oncol; 2006 Apr;79(1):59-64
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  • [Title] Adverse effect of a distended rectum in intensity-modulated radiotherapy (IMRT) treatment planning of prostate cancer.
  • BACKGROUND AND PURPOSE: The retrospective planning study for intensity-modulated radiotherapy (IMRT) of prostate cancer evaluated whether proximal rectum and supra-anal rectum/anal canal should be delineated as separated organs-at-risk (OARs) to achieve optimal dose distributions to the anorectal region.
  • PATIENTS AND METHODS: For 10 patients with localized prostate cancer IMRT plans were generated with the rectum and anal canal as separated OARs (Rec-sep) and as one single OAR (Rec-tot).
  • CONCLUSIONS: For patients with a distended rectum in the planning CT, delineation of separated OARs for proximal rectum and distal rectum/anal canal resulted in superior dose distributions to the anorectal region and therefore, we recommend this as standard procedure for IMRT planning of prostate cancer.

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  • (PMID = 16584794.001).
  • [ISSN] 0167-8140
  • [Journal-full-title] Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
  • [ISO-abbreviation] Radiother Oncol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Ireland
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23. Solaz Moreno E, Vallalta Morales M, Silla Búrdalo G, Cervera Miguel JI, Díaz Beveridge R, Rayón Martín JM: [Primary melanoma of the rectum: an infrequent neoplasia with an atypical presentation]. Clin Transl Oncol; 2005 May;7(4):171-3
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  • [Title] [Primary melanoma of the rectum: an infrequent neoplasia with an atypical presentation].
  • [Transliterated title] Melanoma primario de recto: una neoplasia infrecuente con una forma de presentación atípica.
  • Primary anorectal melanoma is a rare malignancy with an extremely aggressive biological behaviour.
  • [MeSH-major] Melanoma / diagnosis. Rectal Neoplasms / diagnosis

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  • [Cites] Expert Opin Pharmacother. 2003 Dec;4(12):2205-11 [14640919.001]
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  • [Cites] Dis Colon Rectum. 1999 Sep;42(9):1203-8 [10496563.001]
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  • (PMID = 15960927.001).
  • [ISSN] 1699-048X
  • [Journal-full-title] Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
  • [ISO-abbreviation] Clin Transl Oncol
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
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24. Pietsch AP, Fietkau R, Klautke G, Foitzik T, Klar E: Effect of neoadjuvant chemoradiation on postoperative fecal continence and anal sphincter function in rectal cancer patients. Int J Colorectal Dis; 2007 Nov;22(11):1311-7
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  • [Title] Effect of neoadjuvant chemoradiation on postoperative fecal continence and anal sphincter function in rectal cancer patients.
  • BACKGROUND AND AIMS: Neoadjuvant chemoradiation (nCRT) followed by curative surgery has gained acceptance as the therapy of choice in locally advanced rectal cancer.
  • This prospective study evaluates the effect of nCRT on postoperative anorectal function and continence.
  • All patients received a questionnaire to evaluate stool continence and anorectal function before as well as after surgery.
  • Anorectal function was further analyzed by perfusion manometry pre- and postoperatively.
  • Anorectal manometry revealed an impairment of anorectal function after low anterior resection regardless of the treatment regime.
  • CONCLUSION: nCRT does not impair anorectal function and fecal continence.

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  • (PMID = 17497160.001).
  • [ISSN] 0179-1958
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Germany
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25. Chrysos E, Athanasakis E, Vrekousis T, Almarashdah S, Fiorentini G, Xynos E, Zoras O: Abdominal and pelvic stop-flow chemotherapy. Effect of chemotherapeutic agents and tissue ischemia on rectoanal pressures. J Exp Clin Cancer Res; 2006 Sep;25(3):303-8
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  • Furthermore, anorectal motility and sensation are not affected by any direct or indirect toxic action of the chemotherapeutic agents.
  • [MeSH-major] Abdominal Neoplasms / drug therapy. Anal Canal / drug effects. Antineoplastic Agents / pharmacokinetics. Chemotherapy, Cancer, Regional Perfusion / methods. Ischemia / pathology. Pelvic Neoplasms / drug therapy. Rectum / drug effects

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  • (PMID = 17167968.001).
  • [ISSN] 0392-9078
  • [Journal-full-title] Journal of experimental & clinical cancer research : CR
  • [ISO-abbreviation] J. Exp. Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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26. Kim BG, Chang IT, Park JS, Choi YS, Kim GH, Park ES, Choi CH: Transanal excision of a malignant fibrous histiocytoma of anal canal: a case report and literature review. World J Gastroenterol; 2008 Mar 7;14(9):1459-62
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  • [Title] Transanal excision of a malignant fibrous histiocytoma of anal canal: a case report and literature review.
  • Malignant fibrous histiocytoma, which is composed of spindle-shaped cells arranged in a pleomorphic and storiform pattern, is rarely found in the colorectum.
  • We report a case of a 63-year-old woman with an ulcerative lesion in the anorectal junction and a final diagnosis of malignant fibrous histiocytoma.
  • To our knowledge, this is the first case reported in the English literature of a malignant fibrous histiocytoma treated with the transanal local excision and adjuvant radiotherapy.
  • This report showed that this approach is selectively reserved for early-stage malignant fibrous histiocytoma and for those patients who refuse radical surgery because of the risk in a permanent colostomy.
  • [MeSH-major] Anus Neoplasms / surgery. Histiocytoma, Malignant Fibrous / surgery. Proctoscopy / methods

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  • (PMID = 18322967.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 29
  • [Other-IDs] NLM/ PMC2693701
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27. Lapray JF, Costa P, Delmas V, Haab F: [The role of ultrasound in the exploration of pelvic floor disorders]. Prog Urol; 2009 Dec;19(13):947-52
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  • [Transliterated title] Rôle de l'échographie dans l'exploration des troubles de la statique pelvienne.
  • It remains, however, clearly more limited in the precise study of posterior colpoceles, and especially in anorectal disorders, than colpocystodefecography or dynamic MRI.
  • Pelvic and endovaginal ultrasounds should be systematic, in the absence of MRI, in the presurgical assessment of a prolapse: checks for an ovarian lesion or endrometrial cancer (obesity being a risk factor in the menopaused woman), evaluation of uterine volume in the younger woman.

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  • (PMID = 19969264.001).
  • [ISSN] 1166-7087
  • [Journal-full-title] Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
  • [ISO-abbreviation] Prog. Urol.
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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28. Rao SS, Go JT: Update on the management of constipation in the elderly: new treatment options. Clin Interv Aging; 2010 Aug 09;5:163-71
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  • Loss of mobility, medications, underlying diseases, impaired anorectal sensation, and ignoring calls to defecate are as important as dyssynergic defecation or irritable bowel syndrome in causing constipation.
  • Likewise, blood tests and colonoscopy may identify organic causes such as colon cancer.
  • Physiological tests such as colonic transit study with radio-opaque markers or wireless motility capsule, anorectal manometry, and balloon expulsion tests can identify disorders of colonic and anorectal function.

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  • [CommentIn] Clin Interv Aging. 2010;5:417-8 [21904448.001]
  • (PMID = 20711435.001).
  • [ISSN] 1178-1998
  • [Journal-full-title] Clinical interventions in aging
  • [ISO-abbreviation] Clin Interv Aging
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / R01 DK057100; United States / NIDDK NIH HHS / DK / R01 DK 57100-05
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Review
  • [Publication-country] New Zealand
  • [Other-IDs] NLM/ PMC2920196
  • [Keywords] NOTNLM ; constipation / elderly / treatment
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29. Peeters ST, Lebesque JV, Heemsbergen WD, van Putten WL, Slot A, Dielwart MF, Koper PC: Localized volume effects for late rectal and anal toxicity after radiotherapy for prostate cancer. Int J Radiat Oncol Biol Phys; 2006 Mar 15;64(4):1151-61
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  • [Title] Localized volume effects for late rectal and anal toxicity after radiotherapy for prostate cancer.
  • PURPOSE: To identify dosimetric parameters derived from anorectal, rectal, and anal wall dose distributions that correlate with different late gastrointestinal (GI) complications after three-dimensional conformal radiotherapy for prostate cancer.
  • Toxicity was scored with adapted Radiation Therapy Oncology Group/European Organization for the Research and Treatment of Cancer (RTOG/EORTC) criteria and five specific complications.
  • The variables derived from dose-volume histogram of anorectal, rectal, and anal wall were as follows: % receiving > or =5-70 Gy (V5-V70), maximum dose (Dmax), and mean dose (D(mean)).
  • The anus was defined as the most caudal 3 cm of the anorectum.
  • Bleeding correlated most strongly with anorectal V55-V65, and stool frequency with anorectal V40 and D(mean).
  • Therefore, to evaluate the risk of late GI toxicity, not only intermediate and high doses to the anorectal wall volume should be taken into account, but also the dose to the anal wall.

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  • (PMID = 16414208.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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30. Heemsbergen WD, Hoogeman MS, Witte MG, Peeters ST, Incrocci L, Lebesque JV: Increased risk of biochemical and clinical failure for prostate patients with a large rectum at radiotherapy planning: results from the Dutch trial of 68 GY versus 78 Gy. Int J Radiat Oncol Biol Phys; 2007 Apr 1;67(5):1418-24
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  • [Title] Increased risk of biochemical and clinical failure for prostate patients with a large rectum at radiotherapy planning: results from the Dutch trial of 68 GY versus 78 Gy.
  • PURPOSE: To investigate whether a large rectum filling visible on the planning CT scan was associated with a decrease in freedom from any failure (FFF) and freedom from clinical failure (FFCF) for prostate cancer patients.
  • (1) an anorectal volume > or = 90 cm(3) and > or = 25% of treatment-time diarrhea (RF1); and (2) the mean cross-sectional area of the anorectum (RF2).

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  • (PMID = 17241751.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase III; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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31. Wallner C, Lange MM, Bonsing BA, Maas CP, Wallace CN, Dabhoiwala NF, Rutten HJ, Lamers WH, Deruiter MC, van de Velde CJ, Cooperative Clinical Investigators of the Dutch Total Mesorectal Excision Trial: Causes of fecal and urinary incontinence after total mesorectal excision for rectal cancer based on cadaveric surgery: a study from the Cooperative Clinical Investigators of the Dutch total mesorectal excision trial. J Clin Oncol; 2008 Sep 20;26(27):4466-72
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  • [Title] Causes of fecal and urinary incontinence after total mesorectal excision for rectal cancer based on cadaveric surgery: a study from the Cooperative Clinical Investigators of the Dutch total mesorectal excision trial.
  • PURPOSE: Total mesorectal excision (TME) for rectal cancer may result in anorectal and urogenital dysfunction.
  • Additionally, data from the Dutch TME trial were analyzed to relate anorectal and urinary dysfunction to possible nerve damage during TME procedure.

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  • [CommentIn] J Clin Oncol. 2009 Feb 20;27(6):999-1000; author reply 1000-1 [19164200.001]
  • (PMID = 18802159.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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32. Lampinen TM, Latulippe L, van Niekerk D, Schilder AJ, Miller ML, Anema A, Hogg RS: Illustrated instructions for self-collection of anorectal swab specimens and their adequacy for cytological examination. Sex Transm Dis; 2006 Jun;33(6):386-8
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  • [Title] Illustrated instructions for self-collection of anorectal swab specimens and their adequacy for cytological examination.
  • BACKGROUND: Self-collection of anorectal swab specimens would facilitate screening for anal cancer precursors and sexually transmitted rectal infections among men who have sex with men (MSM).
  • CONCLUSIONS: Provided with illustrated instructions, most MSM who are naïve to the technique can self-collect anorectal swab specimens that are suitable for screening.
  • [MeSH-major] Anal Canal / pathology. Homosexuality, Male. Self Care. Sexually Transmitted Diseases / diagnosis

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  • (PMID = 16543863.001).
  • [ISSN] 0148-5717
  • [Journal-full-title] Sexually transmitted diseases
  • [ISO-abbreviation] Sex Transm Dis
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Reagent Kits, Diagnostic
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33. Bruheim K, Guren MG, Skovlund E, Hjermstad MJ, Dahl O, Frykholm G, Carlsen E, Tveit KM: Late side effects and quality of life after radiotherapy for rectal cancer. Int J Radiat Oncol Biol Phys; 2010 Mar 15;76(4):1005-11
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  • [Title] Late side effects and quality of life after radiotherapy for rectal cancer.
  • PURPOSE: There is little knowledge on long-term morbidity after radiotherapy (50 Gy) and total mesorectal excision for rectal cancer.
  • Therefore, late effects on bowel, anorectal, and urinary function, and health-related quality of life (QoL), were studied in a national cohort (n = 535).
  • METHODS AND MATERIALS: All Norwegian patients who received pre- or postoperative (chemo-)radiotherapy for rectal cancer from 1993 to 2003 were identified.
  • Bowel and urinary function was scored with the LENT SOMA scale and the St. Marks Score for fecal incontinence and QoL with the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (QLQ-C30).
  • CONCLUSIONS: Radiotherapy for rectal cancer is associated with considerable long-term effects on anorectal function, especially in terms of bowel frequency and fecal incontinence.

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 19540058.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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34. Lian P, Gu WL, Zhang Z, Cai GX, Wang MH, Xu Y, Sheng WQ, Cai SJ: Retrospective analysis of perianal Paget's disease with underlying anorectal carcinoma. World J Gastroenterol; 2010 Jun 21;16(23):2943-8
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  • [Title] Retrospective analysis of perianal Paget's disease with underlying anorectal carcinoma.
  • METHODS: PPD patients were retrospectively collected in the institutional colorectal database of the Fudan University Shanghai Cancer Center.
  • Detailed patient histories of past medical condition, diagnosis, treatment, and pathological findings were reviewed.
  • Surgical specimen from diagnosis and surgery were reviewed by two independent pathologists for confirmation of diagnoses.
  • All patients had underlying anorectal adenocarcinoma, including seven with synchronous lesions and one with metachronous lesions.
  • Moreover, all anorectal lesions had a mucin-producing component.
  • The median age at diagnosis was 65 (range 29-81 years), and the male/female ratio was 7:1.
  • Underlying anorectal cancer was not unusual and was a significant prognostic factor.
  • Rational treatment of both anorectal cancer and PPD lesion is essential for long-term survival.
  • [MeSH-major] Anus Neoplasms / diagnosis. Paget Disease, Extramammary / diagnosis. Rectal Neoplasms / diagnosis

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  • (PMID = 20556842.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2887592
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35. Tilney HS, Heriot AG, Trickett JP, Massouh H, Edwards DP, Mellor SG, Gudgeon AM: The use of intra-operative endo-anal ultrasound in perianal disease. Colorectal Dis; 2006 May;8(4):338-41
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  • INTRODUCTION: Endoanal ultrasound (EAUS) has demonstrated high sensitivity and specificity for the structural imaging of anorectal pathology.
  • In 22 cases (51.2%) the EAUS findings affected the surgical management (extent of muscle above a fistula 9 cases, extent of sphincterotomy 7 cases, site of sepsis identified 2 cases, exclusion of sepsis 2 cases, assessment of cancer resectability 1 case, biopsy of intersphincteric lesion 1 case).
  • While not essential, it is a useful adjunct especially in recurrent perianal sepsis, undiagnosed anorectal pain and anal fissure.

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  • (PMID = 16630240.001).
  • [ISSN] 1462-8910
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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36. Gurjar SV, Kulkarni D, Khawaja HT: Outpatient general surgical follow-up: are we using this resource effectively? Int J Surg; 2009 Feb;7(1):62-5
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  • One hundred and sixty eight follow-up consultations occurred, which included cancer patients (6%), review patients (12%), patients attending for investigative results (13%) and benign post-operative follow-ups (22%).
  • Forty six of the 69 (66%) post-operative follow-ups were deemed unnecessary as patients were being seen after benign procedures (hernia repair, anorectal surgery or laparoscopic cholecystectomy).

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  • (PMID = 19095510.001).
  • [ISSN] 1743-9159
  • [Journal-full-title] International journal of surgery (London, England)
  • [ISO-abbreviation] Int J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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37. Minicozzi A, Borzellino G, Momo R, Steccanella F, Pitoni F, de Manzoni G: Perianal Paget's disease: presentation of six cases and literature review. Int J Colorectal Dis; 2010 Jan;25(1):1-7
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  • Anorectal adenocarcinoma was already existing in two cases, synchronous in 48, and subsequent to diagnosis in 11.
  • The review of the literature allows a clear identification of the primitive EMPD and the form associated to anorectal adenocarcinoma and little information about cases associated with synchronous adnexal adenocarcinoma.
  • CONCLUSIONS: Up to now, no clear guidelines have been established for the diagnosis of EMPD.

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  • (PMID = 19707774.001).
  • [ISSN] 1432-1262
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 67
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38. Winter L, Bruhn H, Langrehr J, Neuhaus P, Felix R, Hänninen LE: Magnetic resonance imaging in suspected rectal cancer: determining tumor localization, stage, and sphincter-saving resectability at 3-Tesla-sustained high resolution. Acta Radiol; 2007 May;48(4):379-87
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  • [Title] Magnetic resonance imaging in suspected rectal cancer: determining tumor localization, stage, and sphincter-saving resectability at 3-Tesla-sustained high resolution.
  • MATERIAL AND METHODS: Twenty-three patients with suspected rectal cancer underwent unenhanced and contrast-enhanced fat-suppressed pelvic high-resolution MR imaging using a four-channel phased-array pelvic coil at 3T.
  • Image quality, tumor stage, distance from the anorectal margin, and sphincter-saving resectability were prospectively assessed by two blinded readers.
  • MRI allowed correct identification of tumor extension and its relation to surgically relevant pelvic structures including the anorectal margin and mesorectal fascia.
  • Transverse T2-weighted fast spin-echo images compared superiorly to all other sequences for the diagnosis of mesorectal infiltration and lymph node involvement.
  • [MeSH-major] Anal Canal / surgery. Image Processing, Computer-Assisted / methods. Magnetic Resonance Imaging / methods. Rectal Neoplasms / diagnosis
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / pathology. Adenocarcinoma / surgery. Adenomatous Polyps / diagnosis. Adenomatous Polyps / pathology. Adenomatous Polyps / surgery. Aged. Contrast Media. Cytomegalovirus Infections / diagnosis. Fascia / pathology. Humans. Image Enhancement / methods. Lymphatic Metastasis / diagnosis. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Predictive Value of Tests. Preoperative Care. Proctitis / diagnosis. Proctitis / virology. Prospective Studies. Rectum / pathology. Sensitivity and Specificity

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  • (PMID = 17453515.001).
  • [ISSN] 0284-1851
  • [Journal-full-title] Acta radiologica (Stockholm, Sweden : 1987)
  • [ISO-abbreviation] Acta Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Sweden
  • [Chemical-registry-number] 0 / Contrast Media
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39. Du P, Zi SM, Weng ZY, Chen W, Chen Y, Cui L: [Biofeedback therapy for fecal incontinence in patients with mid or low rectal cancer after restorative resection]. Zhonghua Wei Chang Wai Ke Za Zhi; 2010 Aug;13(8):580-2
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  • [Title] [Biofeedback therapy for fecal incontinence in patients with mid or low rectal cancer after restorative resection].
  • OBJECTIVE: To investigate the efficacy of biofeedback therapy for fecal incontinence in patients with mid or low rectal cancer.
  • METHODS: Twenty-four patients with mid or low rectal cancer received biofeedback treatments after restorative resection and therapeutic efficacy was evaluated using anorectal manometry and Vaizey and Wexner scoring systems.
  • RESULTS: The parameters of anorectal manometry in patients with rectal cancer were significantly lower than those in the control group (P<0.01).
  • CONCLUSION: Biofeedback therapy can improve the anal function in patients with rectal cancer after restorative resection.

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  • (PMID = 20737308.001).
  • [ISSN] 1671-0274
  • [Journal-full-title] Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
  • [ISO-abbreviation] Zhonghua Wei Chang Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] China
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40. Homsi J, Garrett C: Melanoma of the anal canal: a case series. Dis Colon Rectum; 2007 Jul;50(7):1004-10
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  • PURPOSE: Anal melanoma is an uncommon and aggressive cancer.
  • Lee Moffitt Cancer and Research Institute between 1987 and 2004 were reviewed.
  • RESULTS: Twelve patients were identified (8 percent of all cancer of the anal canal).
  • Four patients had nodal involvement, and one had bone metastases at the time of diagnosis.
  • Five of the 11 patients without metastatic disease relapsed or died within the first year of diagnosis (4 had local excision and 1 had abdominoperineal resection).
  • CONCLUSIONS: Anorectal melanoma is a rare and challenging disease.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / epidemiology. Prevalence. Radiotherapy, Adjuvant. Retrospective Studies. Survival Rate. Treatment Outcome

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  • (PMID = 17468984.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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41. Iddings DM, Fleisig AJ, Chen SL, Faries MB, Morton DL: Practice patterns and outcomes for anorectal melanoma in the USA, reviewing three decades of treatment: is more extensive surgical resection beneficial in all patients? Ann Surg Oncol; 2010 Jan;17(1):40-4
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  • [Title] Practice patterns and outcomes for anorectal melanoma in the USA, reviewing three decades of treatment: is more extensive surgical resection beneficial in all patients?
  • INTRODUCTION: Historically, the treatment of anorectal melanoma has been abdominoperineal resection (APR), but more recently local resection alone.
  • METHODS: The Surveillance, Epidemiology, and End Results (SEER) database was queried to identify patients treated for anorectal melanoma (1973-2003).
  • CONCLUSION: This study, the largest series to analyze widespread practice patterns and outcomes for anorectal melanoma in the USA, did not reveal a survival difference comparing TAE with APR.

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  • (PMID = 19774417.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA029605-28; United States / NCI NIH HHS / CA / P01 CA029605; United States / NCI NIH HHS / CA / CA29605; United States / NCI NIH HHS / CA / P01 CA029605-28
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS150983; NLM/ PMC2809795
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42. Giovannini M, Ardizzone S: Anorectal ultrasound for neoplastic and inflammatory lesions. Best Pract Res Clin Gastroenterol; 2006 Feb;20(1):113-35
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  • [Title] Anorectal ultrasound for neoplastic and inflammatory lesions.
  • Although, computed tomography and magnetic resonance imaging are very sensitive in detecting metastatic disease, the local staging of rectal cancer with these techniques has been disappointing.
  • Endorectal ultrasound (ERUS) and anal endosonography (AE) remain the most accurate methods for staging rectal and anal cancer.
  • [MeSH-minor] Humans. Imaging, Three-Dimensional. Neoplasm Staging. Sensitivity and Specificity

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  • (PMID = 16473804.001).
  • [ISSN] 1521-6918
  • [Journal-full-title] Best practice & research. Clinical gastroenterology
  • [ISO-abbreviation] Best Pract Res Clin Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 85
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43. van Schaik PM, Ernst MF, Meijer HA, Bosscha K: Melanoma of the rectum: a rare entity. World J Gastroenterol; 2008 Mar 14;14(10):1633-5
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  • Primary anorectal melanoma is a rare and very aggressive disorder.
  • According to current data, one should always perform a S-100 stain when anorectal sarcoma is suspected.
  • Only in the case of large and obstructing tumors an abdomino-perineal resection is the treatment of choice.
  • [MeSH-major] Melanoma / diagnosis. Rectal Neoplasms / diagnosis

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  • (PMID = 18330962.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / S100 Proteins
  • [Other-IDs] NLM/ PMC2693766
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44. Ding WX, Yang P, Deng JZ, Cheng LQ, Liao S: [Comparative study of colostomy in the laparoscopic-assisted abdominoperineal resection]. Zhonghua Wei Chang Wai Ke Za Zhi; 2007 Jul;10(4):326-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Sixty- three cases with anorectal cancer undergone LAPR from June 2001 to December 2005 were registered and followed up.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Anal Canal / surgery. Female. Humans. Laparoscopy. Male. Middle Aged. Neoplasm Staging

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  • (PMID = 17659454.001).
  • [ISSN] 1671-0274
  • [Journal-full-title] Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
  • [ISO-abbreviation] Zhonghua Wei Chang Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] China
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45. Coull DB, Lee FD, Anderson JH, McKee RF, Finlay IG, Dunlop MG: Long-term cancer risk of the anorectal cuff following restorative proctocolectomy assessed by p53 expression and cuff dysplasia. Colorectal Dis; 2007 May;9(4):321-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-term cancer risk of the anorectal cuff following restorative proctocolectomy assessed by p53 expression and cuff dysplasia.
  • OBJECTIVE: Restorative proctocolectomy (RP) for ulcerative colitis (UC) retains a 'cuff' of columnar rectal epithelium that has unknown risk of malignant change.
  • Markers of malignant potential in UC include aberrant p53 expression and dysplasia.
  • We undertook a prospective study comprising serial surveillance biopsy and assessed the occurrence of aberrant p53 expression, epithelial dysplasia and carcinoma in the retained anorectal cuff following stapled RP.
  • Median follow-up was 56 months (12-145) and median time since diagnosis of UC was 8.8 years (2-32).
  • These data suggest that in patients who do not have high-grade dysplasia or colorectal cancer at the time of RP, cuff surveillance in the first decade after pouch formation is unnecessary.

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  • (PMID = 17432983.001).
  • [ISSN] 1462-8910
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / MC/ U127527198
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Tumor Suppressor Protein p53
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46. Goodarzi M, Rashid A, Maru D: Invasive ductal adenocarcinoma arising from pancreatic heterotopia in rectum: case report and review of literature. Hum Pathol; 2010 Dec;41(12):1809-13
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  • Pancreatic heterotopia has been described at several abdominal and intrathoracic locations, most commonly in the stomach and upper part of the small intestine.
  • Its occurrence in the rectum is unusual, and malignant transformation in the rectum has not been reported.
  • The tumor was composed of well to moderately differentiated ductal adenocarcinoma infiltrating through the full thickness of the anorectal wall with extension into the vaginal septum.
  • A focus of ectopic pancreas consisting of exocrine acini and small ducts adjacent to the tumor with some ducts showing mild to severe dysplasia reminiscent of pancreatic intraepithelial neoplasia was also observed.
  • [MeSH-minor] Adult. Biomarkers, Tumor / metabolism. Bone Neoplasms / secondary. Combined Modality Therapy. Female. Humans. Immunoenzyme Techniques. Neoplasm Recurrence, Local. Sacrum

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20869744.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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47. Mandhan P, Beasley S, Hale T, Ellmers L, Roake J, Sullivan M: Sonic hedgehog expression in the development of hindgut in ETU-exposed fetal rats. Pediatr Surg Int; 2006 Jan;22(1):31-6
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  • The aim of this study was to determine the pattern of expression of Shh and its downstream genes during hindgut development in ETU-exposed embryos with anorectal malformations (ARMs).

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  • (PMID = 16369776.001).
  • [ISSN] 0179-0358
  • [Journal-full-title] Pediatric surgery international
  • [ISO-abbreviation] Pediatr. Surg. Int.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Germany
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48. Lampinen TM, Miller ML, Chan K, Anema A, van Niekerk D, Schilder AJ, Taylor R, Hogg RS: Randomized clinical evaluation of self-screening for anal cancer precursors in men who have sex with men. Cytojournal; 2006;3:4
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  • [Title] Randomized clinical evaluation of self-screening for anal cancer precursors in men who have sex with men.
  • BACKGROUND: Self-collection of anorectal swab specimens could greatly facilitate the completion of prerequisite studies and future implementation of anal cancer screening among men who have sex with men (MSM).
  • METHODS: Paired self- and clinician- collected anorectal Dacron swabs for liquid-based (Thin Prep) cytological evaluation were collected in random sequence from a mostly HIV-1 seronegative cohort of young MSM in Vancouver.
  • Among 12 men with biopsy-confirmed high-grade neoplasia, most had abnormal cytological results (including 6 patient and 9 clinician swabs) but few (2 patient and 1 clinician swab) were high-grade.
  • CONCLUSION: Self-collection of anorectal swab specimens for cytologic screening in research and possibly clinical settings appears feasible, particularly if specimen adequacy can be further improved.
  • The severity of biopsy-confirmed anorectal disease is seriously underestimated by cytological screening, regardless of collector.

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  • (PMID = 16549010.001).
  • [ISSN] 1742-6413
  • [Journal-full-title] CytoJournal
  • [ISO-abbreviation] Cytojournal
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1435770
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49. Pollack J, Holm T, Cedermark B, Holmström B, Mellgren A: Long-term effect of preoperative radiation therapy on anorectal function. Dis Colon Rectum; 2006 Mar;49(3):345-52
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  • [Title] Long-term effect of preoperative radiation therapy on anorectal function.
  • PURPOSE: Preoperative radiotherapy improves local control in rectal cancer treatment, but there are few reports on the influence of radiotherapy on anorectal function.
  • The aim of the present study was to assess late effects of short-course, high-dose radiotherapy on anorectal function after low anterior resection for rectal cancer.
  • METHODS: Sixty-four patients, randomized within the Stockholm Radiotherapy Trials and operated on with low anterior resection with or without preoperative radiotherapy (mean, 14 years), previously were followed up with quality-of-life questionnaires, clinical examination, anorectal manometry, and endoanal ultrasound.
  • RESULTS: Impaired anorectal function was common after low anterior resection for rectal cancer and the risk was increased after radiotherapy.
  • At anorectal manometry, irradiated patients had significantly lower resting (35 mmHg vs. 62 mmHg, P < 0,001) and squeeze pressures (104 mmHg vs. 143 mmHg, P = 0.05).
  • CONCLUSIONS: Short-course radiotherapy, including the anal sphincters, impairs anorectal function and increases gastrointestinal symptoms permanently when the anal sphincters are irradiated.

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  • (PMID = 16532369.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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50. Matsuoka H, Nakamura A, Iwamoto K, Sugiyama M, Hachiya J, Atomi Y, Masaki T: Anorectal malignant melanoma: preoperative usefulness of magnetic resonance imaging. J Gastroenterol; 2005 Aug;40(8):836-42
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  • [Title] Anorectal malignant melanoma: preoperative usefulness of magnetic resonance imaging.
  • Magnetic resonance imaging (MRI) findings in three patients with primary anorectal malignant melanoma are described.
  • Two patients had melanotic and one had amelanotic anorectal melanoma.
  • MRI with a pelvic coil and an endorectal coil was useful for staging anorectal melanoma.
  • This article describes the initial report of the use of an endorectal coil for malignant melanoma of the anorectum.
  • [MeSH-major] Anus Neoplasms / diagnosis. Magnetic Resonance Imaging. Melanoma, Amelanotic / diagnosis. Rectal Neoplasms / diagnosis. Sarcoma, Clear Cell / diagnosis

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  • (PMID = 16143890.001).
  • [ISSN] 0944-1174
  • [Journal-full-title] Journal of gastroenterology
  • [ISO-abbreviation] J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
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51. Böhm G, Kirschner-Hermanns R, Decius A, Heussen N, Schumpelick V, Willis S: Anorectal, bladder, and sexual function in females following colorectal surgery for carcinoma. Int J Colorectal Dis; 2008 Sep;23(9):893-900
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  • [Title] Anorectal, bladder, and sexual function in females following colorectal surgery for carcinoma.
  • BACKGROUND: The aim of this study was to establish the incidence of potential postoperative anorectal, bladder, and sexual dysfunction in women following excision of rectal cancer with total mesorectal excision (TME).
  • MATERIALS AND METHODS: All women who underwent a transabdominal rectal resection with TME for cancer between 2000 and 2003 were included.
  • Women with a colonic resection for cancer during the same time period served as the control group.
  • CONCLUSION: After rectal excision, the women showed impairment of their anorectal and sexual function.
  • Our study indicates that women seem to have less functional problems when compared to literature data on dysfunction in male following rectal surgery for cancer.

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  • (PMID = 18535831.001).
  • [ISSN] 0179-1958
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
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52. Porzionato A, Macchi V, Gardi M, Parenti A, De Caro R: Histotopographic study of the rectourethralis muscle. Clin Anat; 2005 Oct;18(7):510-7
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  • Radical perineal prostatectomy, relative to retropubic prostatectomy, has become an increasingly used surgical technique for prostate cancer, following advances in laparoscopic methods for pelvic lymph node dissection.
  • These structural associations suggest a functional cooperation between the two muscles, particularly in determining the anorectal flexure.

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  • [Copyright] Copyright (c) 2005 Wiley-Liss, Inc.
  • (PMID = 16121390.001).
  • [ISSN] 0897-3806
  • [Journal-full-title] Clinical anatomy (New York, N.Y.)
  • [ISO-abbreviation] Clin Anat
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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53. Marks J, Mizrahi B, Dalane S, Nweze I, Marks G: Laparoscopic transanal abdominal transanal resection with sphincter preservation for rectal cancer in the distal 3 cm of the rectum after neoadjuvant therapy. Surg Endosc; 2010 Nov;24(11):2700-7
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  • [Title] Laparoscopic transanal abdominal transanal resection with sphincter preservation for rectal cancer in the distal 3 cm of the rectum after neoadjuvant therapy.
  • BACKGROUND: This study reports the short- and long-term results for a prospective rectal cancer management program using laparoscopic radical transanal abdominal transanal proctosigmoidectomy with coloanal anastomosis (TATA) after neoadjuvant therapy.
  • METHODS: A prospective database included 102 rectal cancer patients treated with laparoscopic TATA from 1998 to 2008.
  • Patients with distant metastasis at presentation, patients with a tumor more than 3 cm from the anorectal ring, and patients not undergoing neoadjuvant therapy were excluded, leaving 79 patients (54 men and 25 women) with a mean age of 59.2 years (range, 22-85 years) for this study.
  • The mean level in the rectum superior to the anorectal ring was 1.2 cm (range, -0.5 to 3 cm).

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  • (PMID = 20414681.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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54. Ruffolo C, Scarpa M, Polese L, D'Amico FE, Boetto R, Pozza A, D'Incà R, Checchin D, Sturniolo GC, Bassi N, Angriman I: Clinical presentation and diagnosis of intestinal adenocarcinoma in Crohn's disease: analysis of clinical predictors and of the life-time risk. J Gastrointest Surg; 2010 Nov;14(11):1746-51
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  • [Title] Clinical presentation and diagnosis of intestinal adenocarcinoma in Crohn's disease: analysis of clinical predictors and of the life-time risk.
  • BACKGROUND: Late diagnosis of cancer in CD often occurs, and the prognosis is poor.
  • The primary aim of this study was to assess the relationship between clinical presentation and diagnosis of intestinal adenocarcinoma in CD; the secondary aim was to evaluate the timing of cancer occurrence in CD patients.
  • Life table analysis and uni/multivariate analyses were performed.
  • RESULTS: Ten men and two women underwent surgery for intestinal cancer in CD with a median age of 50 years (31-68).
  • Carcinomas were localized in the terminal ileum in four cases, right colon in three, transverse colon in one, sigmoid colon in one, rectum in two, and an anorectal fistula in one.
  • Only three patients were pre-operatively diagnosed with cancer.
  • At multivariate analysis only age (OR 1.057 (95% CI 0.999-1.107), p = 0.05) and obstruction (OR 6.530 (95% CI 1.533-27.806), p = 0.01) significantly predicted cancer diagnosis.
  • The risk rate (RR) for cancer occurrence started to rise at the end of the third decade of life (RR = 0.005).
  • The analysis of risk rate for cancer occurrence during overt CD showed that it is initially high at onset (RR = 0.001) and after two other peaks at 150 months from onset, it began to rise again.
  • The presence of Crohn's colitis was associated to a significant risk of cancer (HR = 4.790, p = 0.009) while the use of 5-ASA resulted to be a protective factor against cancer occurrence (HR = 0.122, p = 0.013).
  • DISCUSSION: In CD, rectal bleeding, the most common alarm symptom for intestinal cancer, is not useful for an early diagnosis.
  • There is probably no safe interval of CD where surveillance for intestinal cancer can be omitted.
  • [MeSH-major] Adenocarcinoma / diagnosis. Crohn Disease / complications. Intestinal Neoplasms / diagnosis

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  • (PMID = 20628906.001).
  • [ISSN] 1873-4626
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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55. Murad-Regadas SM, Regadas FS, Rodrigues LV, Barreto RG, Monteiro FC, Landim BB, Holanda EC: Role of three-dimensional anorectal ultrasonography in the assessment of rectal cancer after neoadjuvant radiochemotherapy: preliminary results. Surg Endosc; 2009 Jun;23(6):1286-91
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  • [Title] Role of three-dimensional anorectal ultrasonography in the assessment of rectal cancer after neoadjuvant radiochemotherapy: preliminary results.
  • BACKGROUND: Three-dimensional anorectal ultrasound (3-DAUS) scanning provides accurate information on tumor size and its relation to the anal muscles.
  • The purpose of this study was to evaluate the ability of 3-DAUS to assess response to radiochemotherapy (RCT) for rectal cancer by comparing 3-DAUS images to pathological findings.
  • [MeSH-minor] Adult. Aged. Disease Progression. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoadjuvant Therapy. Neoplasm Staging / methods. Prospective Studies. Young Adult

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  • (PMID = 18813985.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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56. Liang JT, Lai HS, Lee PH, Huang KC: Comparison of functional and surgical outcomes of laparoscopic-assisted colonic J-pouch versus straight reconstruction after total mesorectal excision for lower rectal cancer. Ann Surg Oncol; 2007 Jul;14(7):1972-9
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  • [Title] Comparison of functional and surgical outcomes of laparoscopic-assisted colonic J-pouch versus straight reconstruction after total mesorectal excision for lower rectal cancer.
  • Patients with lower rectal cancer requiring laparoscopic total mesorectal excision were equally randomized to either laparoscopic-assisted colonic J-pouch reconstruction or laparoscopic straight end-to-end anastomosis.
  • The anorectal function of patients by colonic J-pouch were better than those by straight anastomosis in 3 months after operation, as evaluated by stool frequency (mean +/- standard deviation: 4.0 +/- 2.0 vs. 7.0 +/- 2.4 times/day, P < .001); use of antidiarrheal agents (29.2% [n = 7] vs. 75.0% [n = 18], P = .004); and perineal irritation (45.8% [n = 11] vs. 79.2% [n = 19], P = .037).
  • CONCLUSIONS: Because laparoscopic-assisted creation of a colonic J-pouch achieved better short-term functional results of the anorectum and did not increase surgical morbidity, as compared with laparoscopic straight anastomosis, this reconstruction procedure could be recommended to patients with lower rectal cancer requiring laparoscopic total mesorectal excision.
  • [MeSH-major] Intestine, Large / surgery. Proctocolectomy, Restorative / methods. Rectal Neoplasms / surgery

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  • (PMID = 17431725.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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57. Ishizone S, Koide N, Karasawa F, Akita N, Muranaka F, Uhara H, Miyagawa S: Surgical treatment for anorectal malignant melanoma: report of five cases and review of 79 Japanese cases. Int J Colorectal Dis; 2008 Dec;23(12):1257-62
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  • [Title] Surgical treatment for anorectal malignant melanoma: report of five cases and review of 79 Japanese cases.
  • INTRODUCTION: Anorectal malignant melanoma (AMM) is a relatively rare disease.

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  • (PMID = 18633625.001).
  • [ISSN] 0179-1958
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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58. Bouguen G, Siproudhis L, Bretagne JF, Bigard MA, Peyrin-Biroulet L: Nonfistulizing perianal Crohn's disease: clinical features, epidemiology, and treatment. Inflamm Bowel Dis; 2010 Aug;16(8):1431-42
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  • Anorectal strictures associated with rectal lesions should first be managed with medical therapy.
  • Anal cancer is uncommon.
  • Its treatment is similar to that recommended for anal cancer occurring in non-Crohn's disease patients.
  • After reviewing the classification, clinical features, and epidemiology of each type of nonfistulizing perianal lesion (ulceration, stricture, skin tags, and anal cancer), we discuss the efficacy of medical treatment and surgery.

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  • (PMID = 20310013.001).
  • [ISSN] 1536-4844
  • [Journal-full-title] Inflammatory bowel diseases
  • [ISO-abbreviation] Inflamm. Bowel Dis.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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59. Nakabayashi M, Beard C, Kelly SM, Carr-Locke DL, Oh WK: Treatment of a radiation-induced rectal ulcer with hyperbaric oxygen therapy in a man with prostate cancer. Urol Oncol; 2006 Nov-Dec;24(6):503-8
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  • [Title] Treatment of a radiation-induced rectal ulcer with hyperbaric oxygen therapy in a man with prostate cancer.
  • We report a case of a 55-year-old man with prostate cancer, and complaints of tenesmus and severe rectal pain after radiation therapy.
  • The patient was diagnosed with a locally advanced Gleason score 8 prostate cancer and an increased prostate-specific antigen of 42.3 ng/ml.
  • Fourteen months after 3-dimensional conformal radiation therapy, sigmoidoscopy revealed a single chronic deep ulcer at the anorectal junction.


60. Kazimi M, Ulas M, Ibis C, Unver M, Ozsan N, Yilmaz F, Ersoz G, Zeytunlu M, Kilic M, Coker A: A rare cause of recurrent gastrointestinal bleeding: mesenteric hemangioma. World J Emerg Surg; 2009;4:5
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  • The most common causes of lower gastrointestinal hemorrhage in adults are diverticular disease, inflammatory bowel disease, benign anorectal diseases, intestinal neoplasias, coagulopathies and arterio-venous malformations.
  • After partial resection of small bowel segment, the histopathologic examination revealed a cavernous hemagioma of mesenteric origin.Although rare, gastrointestinal hemangioma should be thought in differential diagnosis as a cause of recurrent lower gastrointestinal bleeding.

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  • (PMID = 19178725.001).
  • [ISSN] 1749-7922
  • [Journal-full-title] World journal of emergency surgery : WJES
  • [ISO-abbreviation] World J Emerg Surg
  • [Language] eng
  • [Publication-type] Journal Article
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61. Valentini V, Barba MC, Gambacorta MA: The role of multimodality treatment in M0 rectal cancer: evidence and research. Eur Rev Med Pharmacol Sci; 2010 Apr;14(4):334-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The role of multimodality treatment in M0 rectal cancer: evidence and research.
  • In the last two decades we have seen major advances in the strategy of the treatment of rectal cancer.
  • Many studies demonstrated that MRI is equivalent to histology in measurement of extramural depth, is also highly accurate in staging advanced rectal cancer, in the assessment of mesorectal fascia infiltration and to distinguish cT3 from cT4, in the measuring the distance from the anorectal ring.
  • In this time of changing therapeutic approaches, a common standard for large heterogeneous patient groups will likely be substituted by more individualised therapies.
  • It will depend from new evidence of more tailored diagnosis, surgery, radiotherapy and chemotherapy.

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  • (PMID = 20496544.001).
  • [ISSN] 1128-3602
  • [Journal-full-title] European review for medical and pharmacological sciences
  • [ISO-abbreviation] Eur Rev Med Pharmacol Sci
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 31
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62. Boland E, Hsu A, Brand MI, Saclarides TJ: Hartmann's colostomy reversal: outcome of patients undergoing surgery with the intention of eliminating fecal diversion. Am Surg; 2007 Jul;73(7):664-7; discussion 668
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  • Twenty-one (60%) patients had their Hartmann's for diverticular disease, 7 (20%) for anorectal cancer, 4 (11%) for volvulus, and 3 for miscellaneous reasons.

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  • (PMID = 17674937.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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63. Badin S, Iqbal A, Sikder M, Chang VT: Persistent pain in anal cancer survivors. J Cancer Surviv; 2008 Jun;2(2):79-83
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  • [Title] Persistent pain in anal cancer survivors.
  • INTRODUCTION: Anorectal cancers are highly curable malignancies.
  • IMPLICATIONS FOR CANCER SURVIVORS: Treatment related lumbosacral plexopathy may be an unrecognized consequence of the successful treatment of anal carcinoma.

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  • (PMID = 18648976.001).
  • [ISSN] 1932-2267
  • [Journal-full-title] Journal of cancer survivorship : research and practice
  • [ISO-abbreviation] J Cancer Surviv
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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64. Park JS, Kang SB, Kim DW, Namgung HW, Kim HL: The efficacy and adverse effects of topical phenylephrine for anal incontinence after low anterior resection in patients with rectal cancer. Int J Colorectal Dis; 2007 Nov;22(11):1319-24
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  • [Title] The efficacy and adverse effects of topical phenylephrine for anal incontinence after low anterior resection in patients with rectal cancer.
  • BACKGROUND: Anal incontinence is experienced by some patients with rectal cancer who received low anterior resection.
  • Anal sphincter function was evaluated using anorectal manometry.
  • CONCLUSION: In the patients with anal incontinence after low anterior resection for rectal cancer, phenylephrine gel did not seem to be helpful in relieving symptoms with some adverse effects.

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  • Hazardous Substances Data Bank. PHENYLEPHRINE .
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  • (PMID = 17569063.001).
  • [ISSN] 0179-1958
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Adrenergic alpha-Agonists; 1WS297W6MV / Phenylephrine
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65. Kim JS, Hur H, Kim NK, Kim YW, Cho SY, Kim JY, Min BS, Ahn JB, Keum KC, Kim H, Sohn SK, Cho CH: Oncologic outcomes after radical surgery following preoperative chemoradiotherapy for locally advanced lower rectal cancer: abdominoperineal resection versus sphincter-preserving procedure. Ann Surg Oncol; 2009 May;16(5):1266-73
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  • [Title] Oncologic outcomes after radical surgery following preoperative chemoradiotherapy for locally advanced lower rectal cancer: abdominoperineal resection versus sphincter-preserving procedure.
  • BACKGROUND: Over the past several years, preoperative chemoradiotherapy (CRT) has contributed remarkably to make more sphincter-preserving procedure (SPP) possible for lower rectal cancer.
  • The aim of this study was to compare the outcomes between abdominoperineal resection (APR) and SPP after preoperative CRT in patients with locally advanced lower rectal cancer.
  • METHODS: A retrospective investigation was conducted with a total of 122 patients who underwent radical surgery combined with preoperative CRT for locally advanced lower rectal cancer.
  • Patients who underwent APR had a higher 5-year local recurrence (22.0% vs. 11.5%, P = 0.028) and lower 5-year cancer-specific survival (52.9% vs. 71.1%, P = 0.03) rate than those who underwent SPP.
  • We suggest that sharp perineal dissection and wider cylindrical excision at the level of the anorectal junction are required to avoid CRM involvement and improve oncologic outcomes in patients who undergo APR following preoperative CRT.
  • [MeSH-minor] Chemotherapy, Adjuvant. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Neoadjuvant Therapy. Neoplasm Staging. Radiotherapy, Adjuvant. Retrospective Studies. Treatment Outcome


66. Radcliffe A: Can the results of anorectal (abdominoperineal) resection be improved: are circumferential resection margins too often positive? Colorectal Dis; 2006 Mar;8(3):160-7
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  • [Title] Can the results of anorectal (abdominoperineal) resection be improved: are circumferential resection margins too often positive?
  • Carefully executed surgery for rectal cancer has reduced the incidence of local recurrence after restorative resection.
  • Three recent large prospective series have confirmed the perception of a higher positive circumferential resection margin (CRM) rate after abdominoperineal resection.
  • Tumour spread is different for low tumours and the surgical technique of abdominoperineal resection, perhaps better known as anorectal excision, may vary between surgeons.
  • There is a need to redefine the place of anorectal excision and the contribution that can be made by pre-operative chemoradiation and/or extended surgery to reduce local recurrence and increase survival.
  • Unnecessary R1 or R2 resections and operative perforation can be minimized by an understanding of the surgical anatomy, the pattern of spread and difference in operative technique between anorectal excision and a low restorative operation.
  • With the adoption of even lower restorative resection (intersphincteric) there is a need to reassess the method of anorectal excision.
  • [MeSH-minor] Humans. Neoplasm Recurrence, Local / prevention & control. Treatment Outcome

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  • (PMID = 16466553.001).
  • [ISSN] 1462-8910
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 70
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67. Remzi FH, El Gazzaz G, Kiran RP, Kirat HT, Fazio VW: Outcomes following Turnbull-Cutait abdominoperineal pull-through compared with coloanal anastomosis. Br J Surg; 2009 Apr;96(4):424-9
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  • BACKGROUND: The Turnbull-Cutait abdominoperineal pull-through procedure (T-C) is used as a last resort to avoid permanent diversion in patients with complex anorectal conditions.
  • METHODS: Patients undergoing T-C from 1996 to 2007 were reviewed retrospectively in terms of demographics, diagnosis, indications and postoperative complications.
  • Functional outcomes were compared with those in a matched group of patients undergoing handsewn coloanal anastomosis (CAA) for rectal cancer.
  • CONCLUSION: T-C is an option for patients with complex anorectal conditions that might otherwise require permanent diversion.

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  • [Copyright] (c) 2009 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
  • (PMID = 19283735.001).
  • [ISSN] 1365-2168
  • [Journal-full-title] The British journal of surgery
  • [ISO-abbreviation] Br J Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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68. Gervaz P, Morel P, Vozenin-Brotons MC: Molecular aspects of intestinal radiation-induced fibrosis. Curr Mol Med; 2009 Apr;9(3):273-80
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  • Radiation therapy is a key component of the management of various pelvic tumors, including prostate, gynecological, and anorectal carcinomas.
  • Unfortunately, normal tissues located in the vicinity of target organs are radiosensitive, and long-term cancer survivors may develop late treatment-related injury, most notably radiation-induced fibrosis (RIF) of the small bowel.
  • [MeSH-major] Fibrosis / pathology. Intestinal Diseases. Intestine, Small. Radiotherapy / adverse effects

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  • (PMID = 19355909.001).
  • [ISSN] 1566-5240
  • [Journal-full-title] Current molecular medicine
  • [ISO-abbreviation] Curr. Mol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Platelet-Derived Growth Factor; 0 / Proto-Oncogene Proteins c-sis; 0 / Transforming Growth Factor beta1; 0 / platelet-derived growth factor BB; 139568-91-5 / Connective Tissue Growth Factor; EC 2.7.11.1 / rho-Associated Kinases; EC 3.6.5.2 / rho GTP-Binding Proteins
  • [Number-of-references] 72
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69. Draus JM Jr, Huss SA, Harty NJ, Cheadle WG, Larson GM: Enterocutaneous fistula: are treatments improving? Surgery; 2006 Oct;140(4):570-6; discussion 576-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: We reviewed all cases of gastrointestinal-cutaneous fistula from 1997 to 2005 at 2 large teaching hospitals.
  • We identified 106 patients with enterocutaneous fistula; patients with irritable bowel disease and anorectal fistulas were excluded.
  • Operative repair was performed in 77 patients and was successful in 69 (89%), failing in 6 patients with persistent cancer or infection.
  • The cause of death was persistence or recurrence of cancer in 4 patients and persistent sepsis in 3.

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  • (PMID = 17011904.001).
  • [ISSN] 0039-6060
  • [Journal-full-title] Surgery
  • [ISO-abbreviation] Surgery
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Fibrin Tissue Adhesive; 0 / Gastrointestinal Agents; 0 / Tissue Adhesives; RWM8CCW8GP / Octreotide
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70. Benzoni E, Lorenzin D, Baccarani U, Adani GL, Favero A, Cojutti A, Bresadola F, Uzzau A: Resective surgery for liver tumor: a multivariate analysis of causes and risk factors linked to postoperative complications. Hepatobiliary Pancreat Dis Int; 2006 Nov;5(4):526-33
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  • In 104 colorectal metastases, 71% were due to colon cancer, 25% rectal, 3% sigmoid, and 1% anorectal.
  • In 49 non-colorectal metastases, 22.4% were derived from breast cancer, 63.2% gastrointestinal tumors (excluding colon) and 14.4% other cancers.

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  • (PMID = 17085337.001).
  • [ISSN] 1499-3872
  • [Journal-full-title] Hepatobiliary & pancreatic diseases international : HBPD INT
  • [ISO-abbreviation] HBPD INT
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
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71. Moriya Y: [Selection and techniques of surgical procedures based on the mode of cancer spread of rectal cancer]. Nihon Geka Gakkai Zasshi; 2005 Apr;106(4):302-5
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  • [Title] [Selection and techniques of surgical procedures based on the mode of cancer spread of rectal cancer].
  • The author reviewed recent results of Japanese and international studies on preoperative staging, pathology of bisopied specimens, sentinel node navigation surgery, and single tumor cells in rectal cancer.
  • Examination of circumferential resection margins is incompatible with that of lymph nodes Intersphincteric resection can be an alternative to abdominoperineal resection for selected rectal tumors located at the anorectal junction without compromising the chance for cure.
  • We emphasize that multiinstitutional clinical trials of adjuvant chemoradiotherapy and surgical treatment are indispensable for developing treatments for rectal cancer in Japan.
  • [MeSH-minor] Digestive System Surgical Procedures / methods. Humans. Neoplasm Metastasis / pathology. Neoplasm Staging. Sentinel Lymph Node Biopsy

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  • (PMID = 15859142.001).
  • [ISSN] 0301-4894
  • [Journal-full-title] Nihon Geka Gakkai zasshi
  • [ISO-abbreviation] Nihon Geka Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 14
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72. Chao M, Gibbs P, Tjandra J, Darben P, Lim-Joon D, Jones IT: Evaluation of the use of computed tomography versus conventional orthogonal X-ray simulation in the treatment of rectal cancer. Australas Radiol; 2005 Apr;49(2):122-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Evaluation of the use of computed tomography versus conventional orthogonal X-ray simulation in the treatment of rectal cancer.
  • The aim of this study is to compare and contrast the treatment fields designed using CT versus conventional orthogonal X-ray simulation in the treatment of patients with rectal cancer given preoperative chemotherapy and radiotherapy.
  • The coverage of treatment fields, the volume of treatment fields, and the position of the anorectal junction in relation to the inferior border of the obturator foramen as the delineator of the pelvic floor were evaluated in each patient using CT and conventional orthogonal X-ray simulation.
  • In addition, the inferior border of the obturator foramen proved to be a poor delineator of the pelvic floor with the anorectal junction situated up to 2 cm superiorly in seven of nine patients.
  • In conclusion, CT simulation is superior to conventional orthogonal X-ray simulation when designing treatment fields for patients with rectal cancer.

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  • (PMID = 15845048.001).
  • [ISSN] 0004-8461
  • [Journal-full-title] Australasian radiology
  • [ISO-abbreviation] Australas Radiol
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] Australia
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73. Heyn J, Placzek M, Ozimek A, Baumgaertner AK, Siebeck M, Volkenandt M: Malignant melanoma of the anal region. Clin Exp Dermatol; 2007 Sep;32(5):603-7
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  • [Title] Malignant melanoma of the anal region.
  • Malignant melanoma (MM) of the anal region is an uncommon disease.
  • Owing to delayed diagnosis and early metastases, the prognosis is often poor.
  • Anorectal melanomas (AM) are most common in the rectum, followed by the anal canal and anal verge.
  • Ras mutations, especially in codon 61 of the N-ras oncogene, are common in CM and rare in melanomas of the vulva and anorectum.
  • The diagnosis of an AM is usually made using a biopsy.
  • The tumour was histologically confirmed to be malignant melanoma.
  • [MeSH-minor] Adult. Angiogenesis Inhibitors / therapeutic use. Cancer Vaccines / therapeutic use. Diagnosis, Differential. Humans. Interferon-alpha / therapeutic use. Male. Prognosis. Treatment Outcome

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  • (PMID = 17376215.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Cancer Vaccines; 0 / Interferon-alpha
  • [Number-of-references] 25
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74. Stelzner F: [Regional growth preferences in hereditary, synchronous, and metachronous colorectal carcinomas. Basics of tumor surgery Part II]. Chirurg; 2006 Nov;77(11):1056-60
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  • Malignant changes do not occur randomly in existing adenomas of FAP patients, and the adenomas' cell division--as in other adenomas--is governed by some degree of self-regulation.
  • Clinical decisions about rectal resection must be informed by understanding of the importance of this organ for anorectal continence as well as the described growth of colorectal malignancies.
  • [MeSH-minor] Cell Division / genetics. Cell Division / physiology. Cell Transformation, Neoplastic / genetics. Cell Transformation, Neoplastic / pathology. Chromosome Aberrations. Colorectal Neoplasms, Hereditary Nonpolyposis / genetics. Colorectal Neoplasms, Hereditary Nonpolyposis / pathology. Colorectal Neoplasms, Hereditary Nonpolyposis / surgery. Homeostasis / genetics. Humans. Intestinal Mucosa / pathology. Intestinal Mucosa / surgery. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Prognosis

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  • (PMID = 17072493.001).
  • [ISSN] 0009-4722
  • [Journal-full-title] Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen
  • [ISO-abbreviation] Chirurg
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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75. Sobala A, Herbst F, Novacek G, Vogelsang H: Colorectal carcinoma and preceding fistula in Crohn's disease. J Crohns Colitis; 2010 Jun;4(2):189-93
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: We retrospectively investigated 591 patients with CD who underwent abdominal surgery during the last 10 years (1997-2006) and found seven patients (5 male, 2 female, median age: 53 years (range 37-74)) with colorectal cancer (Dukes A-C), four of them (57%) with fistula associated CRC.
  • RESULTS: Colorectal cancer was significantly (p=0.048) associated with longstanding anorectal fistula (median=11 years (range 0-28 years)) in the CRC group compared to the matched Crohn's patients (median=1 year (range 0-6 years)).
  • Two patients underwent ileocolonoscopy within 1 year before the diagnosis of malignancy and 2 patients underwent MRI of the pelvic region within 4 months.
  • CONCLUSION: Colorectal carcinoma is frequently associated with the presence of longstanding anorectal fistula.

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  • [Copyright] Copyright © 2009 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved.
  • (PMID = 21122504.001).
  • [ISSN] 1876-4479
  • [Journal-full-title] Journal of Crohn's & colitis
  • [ISO-abbreviation] J Crohns Colitis
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Immunosuppressive Agents
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76. Urso E, Serpentini S, Pucciarelli S, De Salvo GL, Friso ML, Fabris G, Lonardi S, Ferraro B, Bruttocao A, Aschele C, Nitti D: Complications, functional outcome and quality of life after intensive preoperative chemoradiotherapy for rectal cancer. Eur J Surg Oncol; 2006 Dec;32(10):1201-8
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  • [Title] Complications, functional outcome and quality of life after intensive preoperative chemoradiotherapy for rectal cancer.
  • AIMS: To investigate early and late complications in 44 patients with locally advanced mid-low rectal cancer enrolled in a phase I-II study, who had received an aggressive chemoradiation treatment (50.4Gy/28F; 5-FU continuous infusion and weekly Oxaliplatin) followed by total mesorectal excision and 5-FU based postoperative chemotherapy.
  • Anorectal function and QoL were also investigated in 22 patients who underwent surgery in the same surgical unit, using the fecal incontinence scoring system (FIS) and EORTC-QLQ-CR38 questionnaires, compiled before and after radiotherapy and at least 8 months after surgery.
  • CONCLUSION: Our findings seem to indicate that this aggressive 5-FU-Oxalipaltin-based treatment implies no impairment of QoL and anorectal function, even if a high rate of late major complications was observed.

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  • (PMID = 16872799.001).
  • [ISSN] 0748-7983
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase I; Clinical Trial, Phase II; Journal Article; Multicenter Study
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; 04ZR38536J / oxaliplatin; U3P01618RT / Fluorouracil
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77. Heemsbergen WD, Hoogeman MS, Hart GA, Lebesque JV, Koper PC: Gastrointestinal toxicity and its relation to dose distributions in the anorectal region of prostate cancer patients treated with radiotherapy. Int J Radiat Oncol Biol Phys; 2005 Mar 15;61(4):1011-8
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  • [Title] Gastrointestinal toxicity and its relation to dose distributions in the anorectal region of prostate cancer patients treated with radiotherapy.
  • PURPOSE: To study the correlations between the dose distributions in the anorectal region and late GI symptoms in patients treated for localized prostate carcinoma.
  • The distributions of the anorectal region were projected on maps, and the dose parameters were calculated.
  • Finally, we tested a series of dose parameters originating from different parts of the anorectal region.
  • For bleeding and mucus loss, the strongest correlation was found for the dose received by the upper 70-80% of the anorectal region (p < 0.01).

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  • (PMID = 15752880.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Clinical Trial; Clinical Trial, Phase III; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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78. Walega P, Kenig J, Richter P, Nowak W: Functional and clinical results of transanal endoscopic microsurgery combined with endoscopic posterior mesorectum resection for the treatment of patients with t1 rectal cancer. World J Surg; 2010 Jul;34(7):1604-8
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  • [Title] Functional and clinical results of transanal endoscopic microsurgery combined with endoscopic posterior mesorectum resection for the treatment of patients with t1 rectal cancer.
  • The study evaluated the influence of combined TEM and EPMR treatment on the anorectal functions of this group of patients.
  • METHODS: Six consecutive patients (3 women and 3 men; mean age, 71.3 years) with T1 cancer of the rectum were operated on using TEM in combination with EPMR as a two-stage procedure between 2007 and 2009.
  • CONCLUSIONS: EPMR in combination with TEM seems to be safe, feasible, and with no impact on the basic anorectal functions.

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  • (PMID = 20174804.001).
  • [ISSN] 1432-2323
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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79. Kakodkar R, Gupta S, Nundy S: Low anterior resection with total mesorectal excision for rectal cancer: functional assessment and factors affecting outcome. Colorectal Dis; 2006 Oct;8(8):650-6
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  • [Title] Low anterior resection with total mesorectal excision for rectal cancer: functional assessment and factors affecting outcome.
  • We analysed the anorectal function of these patients to determine which factors might contribute to this problem.
  • PATIENTS AND METHODS: Between November 2002 and January 2004, 18 consecutive patients (11 males and 7 females) who underwent LARR with total mesorectal excision (TME) for rectal cancer were assessed by anorectal manometry, balloon proctometry and the Wexner continence questionnaire before operation and at 6 months and 1 year following stoma closure.
  • Comparing patients having a good anorectal function (Wexner score > or = 5) with those having an unsatisfactory function, we found that, on multivariate analysis, the factors that independently contributed to a poor outcome at 12 months after operation were the absence of RAIR as well as an MTV and HPZ below the fifth percentile of normal individuals.
  • CONCLUSIONS: Many patients undergoing LARR with TME for rectal cancer experience an anterior resection syndrome that persists for at least 1 year.

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  • (PMID = 16970574.001).
  • [ISSN] 1462-8910
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
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80. Weyandt GH, Becker JC: Prognostic factors and therapy for primary anorectal melanoma. Int J Colorectal Dis; 2006 Jul;21(5):488-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prognostic factors and therapy for primary anorectal melanoma.

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  • [CommentOn] Int J Colorectal Dis. 2004 Mar;19(2):121-3 [12942268.001]
  • [Cites] Dis Colon Rectum. 1997 Jun;40(6):661-8 [9194459.001]
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  • (PMID = 15770493.001).
  • [ISSN] 0179-1958
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] Germany
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81. Junginger T, Gönner U, Trinh TT, Lollert A, Oberholzer K, Berres M: Permanent stoma after low anterior resection for rectal cancer. Dis Colon Rectum; 2010 Dec;53(12):1632-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Permanent stoma after low anterior resection for rectal cancer.
  • Permanent stomas are primarily necessary in cases of poor anorectal function and local recurrence.
  • METHODS: Of 1032 consecutive patients with rectal cancer, 397 were treated by low anterior resection (R0 and R1 resections) between 1985 and 2007 at the Department of General and Abdominal Surgery of the University Hospital, Mainz (Germany).
  • CONCLUSIONS: The possibility of a permanent stoma should be considered when planning surgery for treating rectal cancer.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Anastomosis, Surgical. Chi-Square Distribution. Female. Humans. Logistic Models. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Recurrence, Local. Postoperative Complications. Retrospective Studies. Risk Factors. Statistics, Nonparametric. Treatment Outcome

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  • (PMID = 21178857.001).
  • [ISSN] 1530-0358
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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82. Jeong SY, Chessin DB, Guillem JG: Surgical treatment of rectal cancer: radical resection. Surg Oncol Clin N Am; 2006 Jan;15(1):95-107, vi-vii
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  • [Title] Surgical treatment of rectal cancer: radical resection.
  • Currently, surgery is the only potentially curative treatment modality for rectal cancer.
  • The major goals of surgery for rectal cancer are to optimize oncologic outcome and maintain anorectal and genitourinary function.
  • This article reviews the surgical management of primary rectal cancer and discusses major surgical considerations in the treatment of this disease.

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  • (PMID = 16389152.001).
  • [ISSN] 1055-3207
  • [Journal-full-title] Surgical oncology clinics of North America
  • [ISO-abbreviation] Surg. Oncol. Clin. N. Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 79
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83. Snoj M, Rudolf Z, Cemazar M, Jancar B, Sersa G: Successful sphincter-saving treatment of anorectal malignant melanoma with electrochemotherapy, local excision and adjuvant brachytherapy. Anticancer Drugs; 2005 Mar;16(3):345-8
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  • [Title] Successful sphincter-saving treatment of anorectal malignant melanoma with electrochemotherapy, local excision and adjuvant brachytherapy.
  • Anorectal malignant melanoma is a rare tumor and there is no consensus on whether aggressive or local management is more appropriate.
  • In our case, a large anorectal malignant melanoma was successfully treated preoperatively by electrochemotherapy with cisplatin that, by reducing the tumor size, enabled sphincter-saving local excision.


84. Füredi G, Szilágyi A, Gilde K, Lövey J, Altorjay A: [Primary anorectal melanoma--an uncommon disease with a poor prognosis]. Magy Seb; 2005 Oct;58(5):337-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Primary anorectal melanoma--an uncommon disease with a poor prognosis].
  • [Transliterated title] Primer anorektális melanoma--egy ritka, de igen rossz prognózisú betegség.
  • Primary anorectal melanoma is a rare disease with poor prognosis.
  • Screening for colorectal cancer may help to detect this disease earlier and the early diagnosis should give better outcome.
  • We present a case report and evaluate--based on literature--epidemiology, most common symptoms, histopathology, diagnosis, treatments and the prognosis of primary anorectal melanomas.
  • [MeSH-minor] Chemotherapy, Adjuvant. Diagnosis, Differential. Humans. Immunotherapy. Male. Middle Aged. Prognosis. Radiotherapy, Adjuvant

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  • (PMID = 16496780.001).
  • [ISSN] 0025-0295
  • [Journal-full-title] Magyar sebészet
  • [ISO-abbreviation] Magy Seb
  • [Language] hun
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Hungary
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85. Fokdal L, Honoré H, Høyer M, von der Maase H: Dose-volume histograms associated to long-term colorectal functions in patients receiving pelvic radiotherapy. Radiother Oncol; 2005 Feb;74(2):203-10
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  • BACKGROUND AND PURPOSE: To correlate long-term colorectal dysfunctions following radical radiotherapy for bladder or prostate cancer with clinical parameters and dose-volume histogram parameters of the small intestine, rectum, and anal canal volume.
  • MATERIALS AND METHODS: Seventy-one patients previously treated for bladder or prostate cancer were interviewed following CT-based radiotherapy of 60-70 Gy with questions concerning long-term colorectal dysfunctions.
  • Dose-volume parameters of the small intestine were not related to any late dysfunctions.
  • CONCLUSIONS: A relationship between several late anorectal dysfunctions and dose-volume parameters from the rectum and anal canal volume was demonstrated.
  • It is recommended to exclude the anal canal volume from the high dose-volume and to apply rectal shielding whenever possible to prevent late anorectal dysfunctions.
  • [MeSH-major] Anal Canal / radiation effects. Intestine, Small / radiation effects. Prostatic Neoplasms / radiotherapy. Radiation Injuries. Radiotherapy, Conformal / adverse effects. Rectum / radiation effects. Urinary Bladder Neoplasms / radiotherapy

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  • (PMID = 15734208.001).
  • [ISSN] 0167-8140
  • [Journal-full-title] Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
  • [ISO-abbreviation] Radiother Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
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86. Esfahani SA, Montaser-Kouhsari L, Saeedi P, Sadeghi Z, Kajbafzadeh AM: An antenatally diagnosed rhabdomyosarcoma of the bladder treated without extensive surgery. Nat Rev Urol; 2009 Aug;6(8):449-53
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  • BACKGROUND: A female fetus was followed up from week 30 of gestation after bilateral hydroureteronephrosis and a large pelvic mass were detected on fetal imaging.
  • At birth, the patient had high respiratory rate, a palpable bladder up to the umbilicus and a large pelvic mass, which compressed the anorectal wall.
  • DIAGNOSIS: Botryoid subtype of rhabdomyosarcoma occupying most of the bladder and protruding through the urethra, with bilateral hydroureteronephrosis.
  • [MeSH-major] Infant, Newborn, Diseases / therapy. Prenatal Diagnosis. Rhabdomyosarcoma / diagnosis. Rhabdomyosarcoma / therapy. Urinary Bladder Neoplasms / diagnosis. Urinary Bladder Neoplasms / therapy


87. Devroe H, Coene L, Mortelmans LJ, Jutten G: Colloid carcinoma arising in an anorectal fistula in Crohn's disease: a case report. Acta Chir Belg; 2005 Feb;105(1):110-1
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  • [Title] Colloid carcinoma arising in an anorectal fistula in Crohn's disease: a case report.
  • Carcinoma arising in a chronic anorectal fistula in Crohn's disease is rare, but the association has been reported in the literature.
  • Probably chronic irritation at either end of a fistula can trigger the degeneration of scar tissue into cancer.
  • The diagnosis is difficult, due to lack of specificity of symptoms and signs, and is often delayed, resulting in a poor prognosis.
  • A 70-year-old female, diagnosed with Crohn's disease at the age of 45, developed a pararectal colloid carcinoma in an anorectal fistula that had existed for years.
  • A high index of suspicion and regular surveillance is recommended in chronic anorectal fistulas in Crohn's disease.

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  • (PMID = 15790217.001).
  • [ISSN] 0001-5458
  • [Journal-full-title] Acta chirurgica Belgica
  • [ISO-abbreviation] Acta Chir. Belg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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88. Lim JF, Tjandra JJ, Hiscock R, Chao MW, Gibbs P: Preoperative chemoradiation for rectal cancer causes prolonged pudendal nerve terminal motor latency. Dis Colon Rectum; 2006 Jan;49(1):12-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Preoperative chemoradiation for rectal cancer causes prolonged pudendal nerve terminal motor latency.
  • PURPOSE: A worsened anorectal function after chemoradiation for high-risk rectal cancer is often attributed to radiation damage of the anorectum and pelvic floor.
  • This prospective study evaluated the short-term effect of preoperative combined chemoradiation on anorectal physiologic and pudendal nerve function.
  • METHODS: Sixty-six patients (39 men, 27 women) with localized resectable (T3, T4, or N1) rectal cancer were included in the study.
  • Patients who had rectal cancer with a distal margin within 6 cm of the anal verge had the anus included in the field of radiotherapy (Group A, n = 26).
  • Patients who had rectal cancer with a distal margin 6 to 12 cm from the anal verge had shielding of the anus during radiotherapy (Group B, n = 40).
  • The Wexner continence score, anorectal manometry and pudendal nerve terminal motor latency were assessed at baseline and four weeks after completion of chemoradiation.
  • CONCLUSIONS: Preoperative chemoradiation for rectal cancer carries a significant risk of pudendal neuropathy, which might contribute to the incidence of fecal incontinence after restorative proctectomy for rectal cancer.

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  • (PMID = 16292664.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 12001-76-2 / Vitamin B Complex; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil
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89. Peeters ST, Hoogeman MS, Heemsbergen WD, Hart AA, Koper PC, Lebesque JV: Rectal bleeding, fecal incontinence, and high stool frequency after conformal radiotherapy for prostate cancer: normal tissue complication probability modeling. Int J Radiat Oncol Biol Phys; 2006 Sep 1;66(1):11-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Rectal bleeding, fecal incontinence, and high stool frequency after conformal radiotherapy for prostate cancer: normal tissue complication probability modeling.
  • METHODS AND MATERIALS: This study includes 468 prostate cancer patients participating in a randomized trial comparing 68 with 78 Gy.
  • Dose distributions of anorectal (bleeding and frequency) and anal wall (fecal incontinence) were used.


90. Cera SM, Wexner SD: Muscle transposition: does it still have a role? Clin Colon Rectal Surg; 2005 Feb;18(1):46-54
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  • In European countries, the stimulated graciloplasty continues to evolve, leading to expansion of its use in total anorectal reconstruction for anal atresia and after abdominoperineal resection.

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  • (PMID = 20011340.001).
  • [ISSN] 1530-9681
  • [Journal-full-title] Clinics in colon and rectal surgery
  • [ISO-abbreviation] Clin Colon Rectal Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2780125
  • [Keywords] NOTNLM ; Fecal incontinence / gluteoplasty / graciloplasty / muscle transposition / neosphincter construction
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91. Chessin DB, Hartley J, Cohen AM, Mazumdar M, Cordeiro P, Disa J, Mehrara B, Minsky BD, Paty P, Weiser M, Wong WD, Guillem JG: Rectus flap reconstruction decreases perineal wound complications after pelvic chemoradiation and surgery: a cohort study. Ann Surg Oncol; 2005 Feb;12(2):104-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: The study group consisted of 19 patients with anorectal cancer treated with external beam pelvic radiation followed by APR and RAM flap reconstruction of the perineum.
  • A prospectively collected database was queried to identify a control group (n = 59) with anorectal cancer treated with similar radiation doses that subsequently underwent an APR without a RAM flap during the same time period.
  • CONCLUSIONS: Perineal closure with a RAM flap significantly decreases the incidence of perineal wound complications in patients undergoing external beam pelvic radiation and APR for anorectal neoplasia.


92. O'Lorcain P, Deady S, Comber H: Mortality predictions for colon and anorectal cancer for Ireland, 2003-17. Colorectal Dis; 2006 Jun;8(5):393-401
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mortality predictions for colon and anorectal cancer for Ireland, 2003-17.
  • OBJECTIVE: Colorectal cancer mortality predictions for Ireland are presented for all ages and for the age group 0-64 years.
  • METHODS: Log and log-linear Poisson regression modelling was fitted to colorectal cancer mortality data for each year between 1950 and 2002 to predict average European age standardized mortality rates (EASMRs) per 100,000 person years (100,000 PY(-1)) and average numbers of deaths.
  • RESULTS: EASMRs for colon cancer are predicted to fall to 17.3 100,000 PY(-1) (95%PI 14.4, 20.2) in men and to 8.4 100,000 PY(-1) (95%PI 6.9, 10.2) in women by 2013-17.
  • EASMRs for anorectal cancer are also predicted to fall to 8.0 100,000 PY(-1) (95%PI 6.6, 9.5) in men and to 3.0 100,000 PY(-1) (95%PI 2.3, 3.8) in women by this time.
  • Truncated EASMRs for colon cancer for those aged between 0 and 64 years are predicted over the next 15 years to fall from their current levels to 4.4 100,000 PY(-1) (95%PI 3.0, 5.8) in men and to 2.3 100,000 PY(-1) (95%PI 1.5, 3.2) in women.
  • For anorectal cancer, truncated EASMRs for those aged between 0 and 64 years are also predicted over the next 15 years to fall from their current levels to 2.9 100,000 PY(-1) (95%PI 2.0, 3.8) in men and to 0.9 100,000 PY(-1) (95%PI 0.4, 1.3) in women.


93. Peytremann-Bridevaux I, Arditi C, Froehlich F, O'Malley J, Fairclough P, Le Moine O, Dubois RW, Gonvers JJ, Schusselé Filliettaz S, Vader JP, Juillerat P, Pittet V, Burnand B, EPAGE II Study Group: Appropriateness of colonoscopy in Europe (EPAGE II). Iron-deficiency anemia and hematochezia. Endoscopy; 2009 Mar;41(3):227-33
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  • Colonoscopy for IDA yields one colorectal cancer (CRC) in every 9-13 colonoscopies.
  • Most patients with scant hematochezia have an anorectal or a distal source of bleeding.

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  • (PMID = 19280534.001).
  • [ISSN] 1438-8812
  • [Journal-full-title] Endoscopy
  • [ISO-abbreviation] Endoscopy
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Germany
  • [Number-of-references] 64
  • [Investigator] Agréus L; Beglinger C; Bytzer P; Delvaux M; Eckardt V; Fairclough P; Lacaine F; Le Moine O; Lorenzo-Zúñiga V; Minoli G; Numans M; Oertli D; O'Malley J; Windsor A
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94. Dursun P, Ayhan A, Kuscu E: Nerve-sparing radical hysterectomy for cervical carcinoma. Crit Rev Oncol Hematol; 2009 Jun;70(3):195-205
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  • It has been demonstrated that RH frequently causes bladder dysfunction, anorectal mobility disorders, and sexual dissatisfaction in cervical cancer survivors due to surgical trauma involving the sympathetic and parasympathetic branches of the autonomous innervation of the pelvic organs.

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  • (PMID = 18926716.001).
  • [ISSN] 1879-0461
  • [Journal-full-title] Critical reviews in oncology/hematology
  • [ISO-abbreviation] Crit. Rev. Oncol. Hematol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 57
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95. Gérard JP, Ortholan C, Benezery K, Ginot A, Hannoun-Levi JM, Chamorey E, Benchimol D, François E: Contact X-ray therapy for rectal cancer: experience in Centre Antoine-Lacassagne, Nice, 2002-2006. Int J Radiat Oncol Biol Phys; 2008 Nov 1;72(3):665-70
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  • [Title] Contact X-ray therapy for rectal cancer: experience in Centre Antoine-Lacassagne, Nice, 2002-2006.
  • PURPOSE: To report the results of using contact X-ray (CXR), which has been used in the Centre-Lacassagne since 2002 for rectal cancer.
  • In the 7 patients who underwent TLE first, no local failure was observed, and their anorectal function was good.
  • CONCLUSION: These early results have confirmed that CXR combined with surgery (or alone with EBRT) can play a major role in the conservative and curative treatment of rectal cancer.
  • [MeSH-minor] Aged. Aged, 80 and over. Female. Follow-Up Studies. France. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / epidemiology. Neoplasm Staging. Randomized Controlled Trials as Topic. Retrospective Studies. Time Factors

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  • (PMID = 18455327.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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96. Sermier A, Gervaz P, Egger JF, Dao M, Allal AS, Bonet M, Morel P: Lymph node retrieval in abdominoperineal surgical specimen is radiation time-dependent. World J Surg Oncol; 2006;4:29
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  • BACKGROUND: A low yield of lymph nodes (LN) in abdominoperineal resection (APR) specimen has been associated with preoperative radiation therapy (XRT) in population-based studies, which may preclude adequate staging of anorectal carcinomas.
  • We hypothesized that the number of LN retrieved in APR specimen was correlated with the dose and the timing of pelvic irradiation.
  • There were 12 patients operated for squamous cell carcinoma of the anal canal (SCCA) and 90 for rectal cancer.
  • 83% and 46% of patients with anal and rectal cancer respectively underwent radical/neoadjuvant radiotherapy.
  • The mean +/- SD number of LN in APR specimen was 9.2 +/- 5.9.
  • The mean number of LN in APR specimen was significantly lower in patients who underwent preoperative XRT (8 +/- 5.5 vs. 10.5 +/- 6.1, Mann-Whitney U test, p = 0.02).
  • The mean number of LN was not significantly different after XRT in patients with SCCA than in patients with rectal cancer (6.2 +/- 5.3 vs. 7.8 +/- 5.3, p = 0.33).
  • Finally, there was an inverse correlation between the yield of LN and the time elapsed between XRT and surgery (linear regression coefficient r = -0.32, p = 0.03).
  • 1) radiation therapy affects the yield of LN retrieval in APR specimen;.

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  • (PMID = 16749931.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1524768
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97. Anderson C, Koshy M, Staley C, Esiashvili N, Ghavidel S, Fowler Z, Fox T, Esteves F, Landry J, Godette K: PET-CT fusion in radiation management of patients with anorectal tumors. Int J Radiat Oncol Biol Phys; 2007 Sep 1;69(1):155-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] PET-CT fusion in radiation management of patients with anorectal tumors.
  • PURPOSE: To compare computed tomography (CT) with positron emission tomography-CT (PET-CT) scans with respect to anorectal tumor volumes, correlation in overlap, and influence on radiation treatment fields and patient care.
  • PATIENTS AND METHODS: From March to November 2003, 20 patients with rectal cancer and 3 patients with anal cancer were treated with preoperative or definitive chemoradiation, respectively.
  • For 25% of patients with rectal cancer, PET detected distant metastases and changed overall management.
  • Ten rectal cancer patients underwent surgery.
  • Positron emission tomography can change the management for anorectal tumors by early detection of metastatic disease or disease outside standard radiation fields.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Combined Modality Therapy / methods. Female. Fluorodeoxyglucose F18. Humans. Male. Middle Aged. Neoplasm Staging. Radiopharmaceuticals. Radiotherapy, Conformal / methods. Tumor Burden

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  • (PMID = 17707268.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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98. Nisar PJ, Scott HJ: Myocutaneous flap reconstruction of the pelvis after abdominoperineal excision. Colorectal Dis; 2009 Oct;11(8):806-16
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  • OBJECTIVE: Perineal wound complications after abdominoperineal excision (APE) for anorectal cancer represent a considerable source of morbidity for patients.
  • The implications of an expanding role for radiotherapy in the treatment of low rectal cancer and radical dissection to achieve negative circumferential margins, necessitate close co-operation between colorectal and reconstructive surgeons to achieve APE with reduced wound morbidity.

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  • (PMID = 19055518.001).
  • [ISSN] 1463-1318
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 51
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99. Matsuoka H, Masaki T, Sugiyama M, Atomi Y: Impact of lateral pelvic lymph node dissection on evacuatory and urinary functions following low anterior resection for advanced rectal carcinoma. Langenbecks Arch Surg; 2005 Nov;390(6):517-22
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  • However, the impact of LPLD on bowel function has not yet been determined by means of anorectal physiologic investigation.
  • PATIENTS AND METHODS: Fifty-seven rectal cancer patients who underwent low anterior resection were evaluated with clinical and physiologic parameters.
  • The postoperative bowel and urinary function were evaluated with patients' questionnaire and anorectal manometry before and after the operation.

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  • (PMID = 16133268.001).
  • [ISSN] 1435-2443
  • [Journal-full-title] Langenbeck's archives of surgery
  • [ISO-abbreviation] Langenbecks Arch Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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100. Machado M, Nygren J, Goldman S, Ljungqvist O: Functional and physiologic assessment of the colonic reservoir or side-to-end anastomosis after low anterior resection for rectal cancer: a two-year follow-up. Dis Colon Rectum; 2005 Jan;48(1):29-36
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Functional and physiologic assessment of the colonic reservoir or side-to-end anastomosis after low anterior resection for rectal cancer: a two-year follow-up.
  • PURPOSE: Functional disturbances are common after anterior resection for rectal cancer.
  • Anorectal manometry was performed preoperatively and at six months, one year, and two years postoperatively.

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  • (PMID = 15690654.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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