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1. Metwaly H, Cheng J, Maruyama S, Ohshiro K, Suzuki I, Hoshina Y, Saku T: Establishment and characterization of new cell lines derived from melanotic neuroectodermal tumor of infancy arising in the mandible. Pathol Int; 2005 Jun;55(6):331-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Establishment and characterization of new cell lines derived from melanotic neuroectodermal tumor of infancy arising in the mandible.
  • Three cell systems (MINT1/2/3) derived from a melanotic neuroectodermal tumor of infancy (MNTI) arising in the mandible of a 1-month-old newborn boy have been established, and their cytological natures have been characterized.
  • These immunohistochemical phenotypes were basically the same as those observed in tissue sections, in which, synaptophysin, myelin basic protein, c-myc gene products, carcinoembryonic antigen, and epithelial membrane antigen were also immunolocalized in tumor cells.
  • Karyotyping analyzes revealed that the chromosome numbers of the three cell systems ranged from 60 to 67 with 3n ploidies, and that there were many structural aberrations, such as del(11)(q13), del(22)(q13), add(2)(p11), add(7)(q22), extra copies for chromosomes 1, 2, 3, 5, 7, 9, 10, 11, 12, 16, 20, and 22, der(9)t(9;13)(p13;q12)add(9)(q34), and der(13;21)(q10;q10), which were shared by the three cell systems, while der(19)t(11;19)(q13;p13) was found in MINT1 and MINT3.
  • The established cell systems will be useful for further investigation on the molecular and genetic basis of MNTI to understand its pathogenesis, which is largely unknown.
  • [MeSH-major] Cell Line, Tumor. Mandibular Neoplasms / pathology. Neuroectodermal Tumor, Melanotic / pathology
  • [MeSH-minor] Animals. Antigens, Neoplasm. Carcinoembryonic Antigen / analysis. Cell Differentiation / drug effects. Cholecalciferol / pharmacology. Chromosome Aberrations. Endothelin-3 / pharmacology. Female. Fluorescent Antibody Technique. Humans. Immunohistochemistry. Infant, Newborn. Karyotyping. Keratins / analysis. Male. Melanoma-Specific Antigens. Mice. Mice, Inbred BALB C. Mice, Nude. Mucin-1 / analysis. Myelin Basic Protein / analysis. Neoplasm Proteins / analysis. Neoplasm Transplantation. Neoplasms, Experimental / pathology. Phosphopyruvate Hydratase / analysis. Proto-Oncogene Proteins c-myc / analysis. S100 Proteins / analysis. Transplantation, Heterologous. Vimentin / analysis

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  • (PMID = 15943790.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Carcinoembryonic Antigen; 0 / Endothelin-3; 0 / MYC protein, human; 0 / Melanoma-Specific Antigens; 0 / Mucin-1; 0 / Myelin Basic Protein; 0 / Neoplasm Proteins; 0 / Proto-Oncogene Proteins c-myc; 0 / S100 Proteins; 0 / Vimentin; 1C6V77QF41 / Cholecalciferol; 68238-35-7 / Keratins; EC 4.2.1.11 / Phosphopyruvate Hydratase
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