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Items 1 to 54 of about 54
1. Hamilton S, Macrae D, Agrawal S, Matic D: Melanotic neuroectodermal tumour of infancy. Can J Plast Surg; 2008;16(1):41-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Melanotic neuroectodermal tumour of infancy.
  • Melanotic neuroectodermal tumour of infancy is an extremely rare neoplasm arising in newborns and young children, typically involving the face or cranium.
  • A thorough review of the literature on this unusual tumour is provided, with emphasis on prognostic factors and appropriate treatment.

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  • (PMID = 19554164.001).
  • [ISSN] 1195-2199
  • [Journal-full-title] The Canadian journal of plastic surgery = Journal canadien de chirurgie plastique
  • [ISO-abbreviation] Can J Plast Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC2690629
  • [Keywords] NOTNLM ; MNTI / Maxillectomy / Melanotic / Pediatric / Pigmented
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2. Agarwal P, Saxena S, Kumar S, Gupta R: Melanotic neuroectodermal tumor of infancy: Presentation of a case affecting the maxilla. J Oral Maxillofac Pathol; 2010 Jan;14(1):29-32

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Melanotic neuroectodermal tumor of infancy: Presentation of a case affecting the maxilla.
  • Melanotic neuroectodermal tumor of infancy is a rare, distinctive neoplasm of early infancy with rapid expansile growth and a high rate of recurrence.

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  • (PMID = 21180456.001).
  • [ISSN] 1998-393X
  • [Journal-full-title] Journal of oral and maxillofacial pathology : JOMFP
  • [ISO-abbreviation] J Oral Maxillofac Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2995998
  • [Keywords] NOTNLM ; Benign neoplasm / maxilla / melanotic neuroectodermal tumor of infancy
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3. Renner LA, Abdulai AE: Melanotic neuroectodermal tumour of infancy (progonoma) treated by radical maxillary surgery. Ghana Med J; 2009 Jun;43(2):90-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Melanotic neuroectodermal tumour of infancy (progonoma) treated by radical maxillary surgery.
  • Two cases of melanotic neuroectodermal tumour of infancy (MNTI), otherwise known as melanotic progonoma, both arising from the maxilla are presented here.
  • Radical surgery consisting of wide resection of the tumour with margins of healthy tissue via hemi-maxillectomy was performed in each case as an initial method of treatment.
  • One infant was then lost to follow up thereafter but the other was reviewed three years later, and apart from slight facial asymmetry, there was no evidence of tumour recurrence.

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  • (PMID = 21326849.001).
  • [ISSN] 0016-9560
  • [Journal-full-title] Ghana medical journal
  • [ISO-abbreviation] Ghana Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ghana
  • [Other-IDs] NLM/ PMC3039233
  • [Keywords] NOTNLM ; Melanotic neuroectodermal tumour of infancy / melanotic progonoma / radical maxillary surgery
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4. Hered RW, Smithwick W 4th, Sandler E, Goldstein JD: Orbital melanotic neuroectodermal tumor of infancy successfully treated with chemotherapy and subtotal excision. J AAPOS; 2007 Oct;11(5):504-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Orbital melanotic neuroectodermal tumor of infancy successfully treated with chemotherapy and subtotal excision.
  • Melanotic neuroectodermal tumor of infancy is a rare condition that typically presents within the first 6 months of life.
  • Melanotic neuroectodermal tumor of infancy has been reported under several other names including retinal anlage tumor and melanotic progonoma.
  • Most commonly, melanotic neuroectodermal tumor of infancy originates in the maxilla.
  • Tumors in previously reported orbital cases have arisen from adjacent structures or from orbital bone.
  • Recommended treatment of melanotic neuroectodermal tumor of infancy has consisted of complete excision with wide tissue margins, although success has been reported after incomplete resection.
  • For those patients in whom surgical resection is not possible, various chemotherapy approaches have been reported with mixed results ranging from failure to sustained tumor regression.
  • We report a case of orbital melanotic neuroectodermal tumor of infancy adherent to sclera and successfully treated with chemotherapy and subtotal excision.

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  • (PMID = 17532239.001).
  • [ISSN] 1091-8531
  • [Journal-full-title] Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus
  • [ISO-abbreviation] J AAPOS
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 6PLQ3CP4P3 / Etoposide; UM20QQM95Y / Ifosfamide
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5. Pattanayak Mohanty S, Ray JG, Richa, Mukherjee S, Mandal C, Chaudhuri K: Melanotic neuroectodermal tumour of infancy. BMJ Case Rep; 2010;2010

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Melanotic neuroectodermal tumour of infancy.
  • Melanotic neuroectodermal tumour of infancy (MNTI) is a rare benign tumour of neural crest origin that was first described by Krompecher in 1918.1 It is predominantly found in infancy, with about 92% of cases below the age of 12 months and 82% below the age of 6 months.
  • The present report deals with two cases of MNTI, a 5-month-old baby girl and a 6-month-old baby boy who reported to the Department of Oral and Maxillofacial Pathology, Dr R Ahmed Dental College and Hospital, Kolkata, India.
  • The clinical, radiological, histological and immunohistochemical findings, confirmed the diagnosis of MNTI.
  • The tumours were treated surgically with no history of recurrence to date.
  • [MeSH-major] Maxillary Neoplasms / diagnosis. Neuroectodermal Tumor, Melanotic / diagnosis

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  • (PMID = 22797196.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3029448
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6. Jain P, Garg RK, Kapoor A: Melanotic neuroectodermal tumor of infancy in oral cavity at unusual age. Fetal Pediatr Pathol; 2010;29(5):344-52

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Melanotic neuroectodermal tumor of infancy in oral cavity at unusual age.
  • The melanotic neuroectodermal tumor of infancy is an extremely rare, fast-growing but benign lesion, commonly occurring in the maxilla of children within the first year of life.
  • Only about 380 cases of this particular tumor have been documented in the medical literature and very few of them have been reported to have occurred in late childhood.
  • We describe here a relatively uncommon presentation of melanotic neuroectodermal tumor of infancy of maxilla arising from palatal gingiva of a 10 year-old female, its course and management by surgical excision with safe margins.
  • [MeSH-major] Maxilla / pathology. Maxillary Neoplasms / pathology. Neuroectodermal Tumor, Melanotic / pathology

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  • (PMID = 20704481.001).
  • [ISSN] 1551-3823
  • [Journal-full-title] Fetal and pediatric pathology
  • [ISO-abbreviation] Fetal Pediatr Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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7. Retna Kumari N, Sreedharan S, Balachandran D: Melanotic neuroectodermal tumour of infancy: a case report. J Indian Soc Pedod Prev Dent; 2007 Jul-Sep;25(3):148-51

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Melanotic neuroectodermal tumour of infancy: a case report.
  • A case of melanotic neuroectodermal tumor of infancy occurring in the maxilla in a 13 day old neonate is described.
  • The recurrence may have been caused by incomplete removal of the tumor cells and the initial surgical procedure may have stimulated tumour cell proliferation.
  • [MeSH-major] Maxillary Neoplasms / congenital. Neuroectodermal Tumor, Melanotic / congenital
  • [MeSH-minor] Biopsy, Fine-Needle. Cell Nucleus / ultrastructure. Cell Proliferation. Cytoplasm / ultrastructure. Follow-Up Studies. Humans. Infant, Newborn. Male. Neoplasm Recurrence, Local / pathology. Tomography, X-Ray Computed

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  • (PMID = 17951934.001).
  • [ISSN] 0970-4388
  • [Journal-full-title] Journal of the Indian Society of Pedodontics and Preventive Dentistry
  • [ISO-abbreviation] J Indian Soc Pedod Prev Dent
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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8. Butt FM, Guthua SW, Chindia ML, Rana F, Osundwa TM: Early outcome of three cases of melanotic neuroectodermal tumour of infancy. J Craniomaxillofac Surg; 2009 Dec;37(8):434-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Early outcome of three cases of melanotic neuroectodermal tumour of infancy.
  • Melanotic neuroectodermal tumour of infancy (MNTI)/progonoma is a rare lesion affecting infants.
  • This article contributes three more cases of MNTI surgically managed at our institution.
  • [MeSH-major] Maxillary Neoplasms / surgery. Neuroectodermal Tumor, Melanotic / surgery

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  • (PMID = 19836964.001).
  • [ISSN] 1878-4119
  • [Journal-full-title] Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
  • [ISO-abbreviation] J Craniomaxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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9. Matsumoto M, Sakuma J, Suzuki K, Kawakami M, Sasaki T, Kodama N: Melanotic neuroectodermal tumor of infancy in the skull: case report and review of the literature. Surg Neurol; 2005 Mar;63(3):275-80

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Melanotic neuroectodermal tumor of infancy in the skull: case report and review of the literature.
  • BACKGROUND: Melanotic neuroectodermal tumor of infancy (MNTI) is a rare neoplasm that develops during the first year of life and grows rapidly.
  • We report a rare case of MNTI in the skull and discuss the importance of the radical surgery and the long-term follow-up results.
  • CASE PRESENTATION: We describe a case of a 4-month-old girl with an MNTI in the skull who underwent the operation 11 years ago.
  • By referring to the histological findings of frozen section during surgery, a total excision of the tumor including its adjacent hypertrophic bone was performed.
  • The patient has remained well without evidence of recurrence or neurological abnormality for 11 years.
  • CONCLUSION: Radical surgery for MNTI provides complete cure.
  • Especially in cases in which tumors recur, follow-up should be for longer periods because of the possibility of its malignant change.
  • [MeSH-major] Neuroectodermal Tumor, Melanotic / pathology. Neuroectodermal Tumor, Melanotic / surgery. Skull Neoplasms / pathology. Skull Neoplasms / surgery. Temporal Bone / pathology. Temporal Bone / surgery
  • [MeSH-minor] Child. Disease-Free Survival. Ectoderm / pathology. Ectoderm / ultrastructure. Female. Frontal Bone / pathology. Frontal Bone / radiography. Frontal Bone / surgery. Humans. Infant. Microscopy, Electron, Transmission. Neurosurgical Procedures. Sphenoid Bone / pathology. Sphenoid Bone / radiography. Sphenoid Bone / surgery. Tomography, X-Ray Computed

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  • (PMID = 15734527.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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10. Choi IS, Kook H, Han DK, Baek HJ, Jung ST, Lee JH, Park JG, Hwang TJ: Melanotic neuroectodermal tumor of infancy in the femur: a case report and review of the literature. J Pediatr Hematol Oncol; 2007 Dec;29(12):854-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Melanotic neuroectodermal tumor of infancy in the femur: a case report and review of the literature.
  • Melanotic neuroectodermal tumor of infancy (MNTI) is an uncommon neoplasm that most often affects the maxilla in the first year of life.
  • MNTI occurring in the long bones is extremely rare, with only 2 cases reported in the medical literature.
  • Here we report a case of MNTI in the right femur of a 5-month-old infant who underwent neoadjuvant chemotherapy followed by limb-salvage surgery.
  • [MeSH-major] Femoral Neoplasms / radiography. Femoral Neoplasms / surgery. Neuroectodermal Tumors, Primitive, Peripheral / radiography. Neuroectodermal Tumors, Primitive, Peripheral / surgery

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  • (PMID = 18090938.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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11. Metwaly H, Cheng J, Maruyama S, Ohshiro K, Suzuki I, Hoshina Y, Saku T: Establishment and characterization of new cell lines derived from melanotic neuroectodermal tumor of infancy arising in the mandible. Pathol Int; 2005 Jun;55(6):331-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Establishment and characterization of new cell lines derived from melanotic neuroectodermal tumor of infancy arising in the mandible.
  • Three cell systems (MINT1/2/3) derived from a melanotic neuroectodermal tumor of infancy (MNTI) arising in the mandible of a 1-month-old newborn boy have been established, and their cytological natures have been characterized.
  • These immunohistochemical phenotypes were basically the same as those observed in tissue sections, in which, synaptophysin, myelin basic protein, c-myc gene products, carcinoembryonic antigen, and epithelial membrane antigen were also immunolocalized in tumor cells.
  • Karyotyping analyzes revealed that the chromosome numbers of the three cell systems ranged from 60 to 67 with 3n ploidies, and that there were many structural aberrations, such as del(11)(q13), del(22)(q13), add(2)(p11), add(7)(q22), extra copies for chromosomes 1, 2, 3, 5, 7, 9, 10, 11, 12, 16, 20, and 22, der(9)t(9;13)(p13;q12)add(9)(q34), and der(13;21)(q10;q10), which were shared by the three cell systems, while der(19)t(11;19)(q13;p13) was found in MINT1 and MINT3.
  • The established cell systems will be useful for further investigation on the molecular and genetic basis of MNTI to understand its pathogenesis, which is largely unknown.
  • [MeSH-major] Cell Line, Tumor. Mandibular Neoplasms / pathology. Neuroectodermal Tumor, Melanotic / pathology
  • [MeSH-minor] Animals. Antigens, Neoplasm. Carcinoembryonic Antigen / analysis. Cell Differentiation / drug effects. Cholecalciferol / pharmacology. Chromosome Aberrations. Endothelin-3 / pharmacology. Female. Fluorescent Antibody Technique. Humans. Immunohistochemistry. Infant, Newborn. Karyotyping. Keratins / analysis. Male. Melanoma-Specific Antigens. Mice. Mice, Inbred BALB C. Mice, Nude. Mucin-1 / analysis. Myelin Basic Protein / analysis. Neoplasm Proteins / analysis. Neoplasm Transplantation. Neoplasms, Experimental / pathology. Phosphopyruvate Hydratase / analysis. Proto-Oncogene Proteins c-myc / analysis. S100 Proteins / analysis. Transplantation, Heterologous. Vimentin / analysis

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  • (PMID = 15943790.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Carcinoembryonic Antigen; 0 / Endothelin-3; 0 / MYC protein, human; 0 / Melanoma-Specific Antigens; 0 / Mucin-1; 0 / Myelin Basic Protein; 0 / Neoplasm Proteins; 0 / Proto-Oncogene Proteins c-myc; 0 / S100 Proteins; 0 / Vimentin; 1C6V77QF41 / Cholecalciferol; 68238-35-7 / Keratins; EC 4.2.1.11 / Phosphopyruvate Hydratase
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12. Desai S, Roy S, Borges AM: Recurrent melanotic neuroectodermal tumour of infancy of the epididymis and testis: a case report. Indian J Pathol Microbiol; 2005 Jul;48(3):363-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recurrent melanotic neuroectodermal tumour of infancy of the epididymis and testis: a case report.
  • Melanotic neuroectodermal tumor of infancy or melanotic progonoma is an uncommon tumor, presenting in infants.
  • This tumor can be confused with round cell tumor (RCT).
  • Since the treatment modality and prognosis of melanotic progonoma and RCT are very different, it is imperative to make a correct diagnosis.
  • [MeSH-major] Epididymis / pathology. Neuroectodermal Tumor, Melanotic. Testicular Neoplasms

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  • (PMID = 16761753.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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13. Kumar Dutta H: Jaw and gum tumours in children. Pediatr Surg Int; 2009 Sep;25(9):781-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Jaw and gum tumours in children.
  • INTRODUCTION: Jaw and gum tumours are rare conditions in children.
  • Children presenting with jaw tumours during 2001 till 2007 are presented.
  • MATERIALS AND METHODS: Fourteen children presenting with jaw and gum tumours are retrospectively analysed.
  • Relevant literature of three rare tumours noted in our series are reviewed.
  • Melanotic neuroectodermal tumour of infancy was noted in two patients.
  • Ameloblastic fibrosis, another rare tumour in children, and non-osseus fibroma were noted in one patient each.
  • CONCLUSION: Jaw and gum tumours in children are usually benign.
  • Excision of the tumour or curettage is curative in most of them.
  • [MeSH-minor] Bone Cysts, Aneurysmal / pathology. Bone Cysts, Aneurysmal / surgery. Child. Child, Preschool. Curettage. Edema / etiology. Female. Fibroma / pathology. Fibroma / surgery. Follow-Up Studies. Granuloma, Giant Cell / pathology. Granuloma, Giant Cell / surgery. Humans. Infant. Infant, Newborn. Male. Neuroectodermal Tumor, Melanotic / pathology. Neuroectodermal Tumor, Melanotic / surgery. Pain / etiology. Retrospective Studies

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  • [Cites] Arch Dis Child. 1989 Jan;64(1):145-7 [2923466.001]
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  • (PMID = 19669649.001).
  • [ISSN] 1437-9813
  • [Journal-full-title] Pediatric surgery international
  • [ISO-abbreviation] Pediatr. Surg. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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14. Ellison DA, Adada B, Qualman SJ, Parham DM: Melanotic neuroectodermal tumor of infancy: report of a case with myogenic differentiation. Pediatr Dev Pathol; 2007 Mar-Apr;10(2):157-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Melanotic neuroectodermal tumor of infancy: report of a case with myogenic differentiation.
  • An 8-month-old boy presented with a 6-week history of a skull mass of the anterior fontanelle.
  • The mass was excised, and the histopathologic features were diagnostic for melanotic neuroectodermal tumor of infancy.
  • The tumor showed focal myogenin positivity, which has not been previously reported in this tumor.
  • The patient has no evidence of recurrent tumor 10 months after the excision.
  • In addition, we stained a case of melanotic neuroectodermal tumor of infancy obtained from Columbus Children's Hospital; focal myogenin positivity was present.
  • [MeSH-major] Myogenin / metabolism. Neuroectodermal Tumor, Melanotic / diagnosis. Skull Neoplasms / diagnosis
  • [MeSH-minor] Antigens, Neoplasm. Follow-Up Studies. Humans. Immunohistochemistry. Infant. Keratins / metabolism. Male. Melanoma-Specific Antigens. Neoplasm Proteins / metabolism. Phosphopyruvate Hydratase / metabolism. Time Factors. Treatment Outcome

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  • (PMID = 17378694.001).
  • [ISSN] 1093-5266
  • [Journal-full-title] Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
  • [ISO-abbreviation] Pediatr. Dev. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Melanoma-Specific Antigens; 0 / Myogenin; 0 / Neoplasm Proteins; 68238-35-7 / Keratins; EC 4.2.1.11 / Phosphopyruvate Hydratase
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15. Elli M, Aydin O, Pinarli FG, Dagdemir A, Dabak N, Selcuk MB, Acar S: Melanotic neuroectodermal tumor of infancy of the femur. Pediatr Hematol Oncol; 2006 Oct-Nov;23(7):579-86

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Melanotic neuroectodermal tumor of infancy of the femur.
  • Melanotic neuroectodermal tumor of infancy (MNTI) is a rare neoplasm that often occurs during the first year of life.
  • MNTI has also been reported in the mediastinum, thigh, foot, shoulder, and gonads.
  • Here the authors report a rare case of MNTI of the femur in a 3-month-old child.
  • [MeSH-major] Femoral Neoplasms / diagnosis. Neuroectodermal Tumor, Melanotic / diagnosis

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  • (PMID = 16928653.001).
  • [ISSN] 1521-0669
  • [Journal-full-title] Pediatric hematology and oncology
  • [ISO-abbreviation] Pediatr Hematol Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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16. Gudinaviciene I, Pranys D, Zheng P, Kros JM: A 10-month-old boy with a large pineal tumor. Brain Pathol; 2005 Jul;15(3):263-4, 267

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A 10-month-old boy with a large pineal tumor.
  • February 2005. Case report of a 10-month-old boy with a large tumor located in the pineal gland, consisting of glia, ganglion cells, pigmented neuroepithelium and striated muscle, without immature components.
  • The combination of neuroectodermal and mesenchymal constituents includes entities as pineal anlage tumor (melanotic neuroectodermal tumor of infancy, MNTI), ectomesenchymoma, medullomyoblastoma, and teratoma in the differential diagnosis.
  • Retinal anlage tumors, to be considered as MNTI at the site of the pineal gland, usually harbor immature components as well.
  • Therefore, the present case does not match strict criteria of any of the categories mentioned and therefore we have designated it as a "pineal anlage tumor (without immature components)".

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  • (PMID = 16196394.001).
  • [ISSN] 1015-6305
  • [Journal-full-title] Brain pathology (Zurich, Switzerland)
  • [ISO-abbreviation] Brain Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Switzerland
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17. Chaudhary A, Wakhlu A, Mittal N, Misra S, Mehrotra D, Wakhlu AK: Melanotic neuroectodermal tumor of infancy: 2 decades of clinical experience with 18 patients. J Oral Maxillofac Surg; 2009 Jan;67(1):47-51

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Melanotic neuroectodermal tumor of infancy: 2 decades of clinical experience with 18 patients.
  • PURPOSE: The purpose of this article is to report our experience in the management of 18 patients with melanotic neuroectodermal tumor of infancy involving the maxillary alveolus.
  • All surgeries were performed using endotracheal anesthesia, and complete gross excision of the tumor was achieved with coverage of the defect with mucoperiosteal flaps.
  • RESULTS: The expansion of the alveolus produced by the tumor improved in 4 to 6 months.
  • CONCLUSIONS: In the absence of metastatic disease, melanotic neuroectodermal tumors of infancy can be successfully managed by local excision.
  • [MeSH-major] Biomarkers, Tumor / urine. Maxillary Neoplasms / surgery. Neuroectodermal Tumor, Melanotic / surgery. Vanilmandelic Acid / urine

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  • (PMID = 19070747.001).
  • [ISSN] 1531-5053
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 55-10-7 / Vanilmandelic Acid
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18. Kantar M, Sezak M, Turhan T, Kitis O, Mutluer S, Demirag BK, Aksoylar S, Akalin T, Ersahin Y, Cetingul N: Melanotic progonoma of the skull in infancy. Childs Nerv Syst; 2008 Nov;24(11):1371-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Melanotic progonoma of the skull in infancy.
  • INTRODUCTION: Melanotic progonoma or melanotic neuroectodermal tumor is a rare tumor in infancy.
  • CASE REPORT: The authors present a case of a 4-month-old infant with left retroauricular mass.
  • The tumor was removed by surgery.
  • A tumor, brownish-black in color, was diagnosed as melanotic progonoma.
  • Benign or malignant lesions can be differentiated by craniography, CT, or MRI scans, but exact diagnosis of melanotic progonoma is made by histopathology and immunostaining, as was in the presented case.
  • Cranial vault progonomas have a better outcome by complete surgery.
  • The tumors usually do not recur in long-term period.
  • [MeSH-major] Neuroectodermal Tumor, Melanotic / diagnostic imaging. Neuroectodermal Tumor, Melanotic / pathology. Skull Neoplasms / diagnostic imaging. Skull Neoplasms / pathology

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  • [Cites] J Craniofac Surg. 2007 Mar;18(2):450-4 [17414302.001]
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  • (PMID = 18592253.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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19. Madrid C, Aziza J, Hlali A, Bouferrache K, Abarca M: Melanotic neuroectodermal tumour of infancy: a case report and review of the aetiopathogenic hypotheses. Med Oral Patol Oral Cir Bucal; 2010 Sep;15(5):e739-42

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Melanotic neuroectodermal tumour of infancy: a case report and review of the aetiopathogenic hypotheses.
  • The case of a 2-month-old healthy infant without relevant medical history.
  • The patient was referred due to the aggravation of a swelling occupying the left half of the anterior maxilla.
  • The tooth buds of 6.1 and 6.2 were closely related to the tumour and so were removed.
  • The pathology of the lesion confirmed a melanotic neuroectodermal tumour of infancy.
  • The melanotic neuroectodermal tumour of infancy (MNTI) has been described as a rare benign pigmented painless swelling that usually occurs in the anterior region of the maxilla and in the incisor region.
  • According to Krompecher this tumour derives from epithelial nests evolved at the time of embryonic fusion of the facial processes.
  • It has also been suggested that the tumour arises from the retinal anlage by a pinching-off process of neuroepithelium during the formation of embryonic eye.
  • More recently, the presence of high levels of vanillylmandelic acid suggest a neural origin of the tumour.
  • [MeSH-major] Maxillary Neoplasms. Neuroectodermal Tumor, Melanotic

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  • (PMID = 20173714.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Spain
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20. Polydorides AD, Perry A, Edgar MA: Large cell medulloblastoma with myogenic and melanotic differentiation: a case report with molecular analysis. J Neurooncol; 2008 Jun;88(2):193-7
Genetic Alliance. consumer health - Medulloblastoma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Large cell medulloblastoma with myogenic and melanotic differentiation: a case report with molecular analysis.
  • We present a case of large cell medulloblastoma with myogenic and melanotic differentiation arising in the cerebellar vermis of a 2-year-old boy and following an aggressive clinical course.
  • Histologic and immunohistochemical features of this tumor include primitive neuronal, rhabdomyoblastic, and pigmented epithelial elements, along with large cell features.
  • Immunohistochemical and molecular data (c-myc gene amplification and the presence of isochromosome 17q) support the contention that this histologically diverse tumor represents a pattern of medulloblastoma with striated muscle and pigmented epithelial differentiation, rather than a teratoma or a cerebellar variant of melanotic neuroectodermal tumor of infancy ('progonoma').
  • [MeSH-major] Cerebellar Neoplasms. Medulloblastoma. Neoplasms, Muscle Tissue / pathology. Neuroectodermal Tumors, Primitive / pathology
  • [MeSH-minor] Antigens, Neoplasm / metabolism. Cell Differentiation. Child, Preschool. Chromosomes, Human, Pair 17. Epithelium / pathology. Epithelium / ultrastructure. Glial Fibrillary Acidic Protein / metabolism. Humans. Karyotyping / methods. Keratins / metabolism. Male. Melanoma-Specific Antigens. Muscle Development. Neoplasm Proteins / metabolism. Proto-Oncogene Proteins c-myc / genetics

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  • (PMID = 18317693.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Glial Fibrillary Acidic Protein; 0 / MYC protein, human; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins; 0 / Proto-Oncogene Proteins c-myc; 68238-35-7 / Keratins
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21. Karkuzhali P, Deiveegan K, Pari: Melanotic medulloblastoma of cerebellum: a case report. Indian J Pathol Microbiol; 2005 Apr;48(2):243-4
Genetic Alliance. consumer health - Medulloblastoma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Melanotic medulloblastoma of cerebellum: a case report.
  • A case of 7 yr old boy with cerebellar melanotic medulloblastoma is reported.
  • Melanotic medulloblastoma is a variant of medulloblastoma, which shares some of the histological features of Melanotic neuroectodermal tumor of infancy.
  • The melanin pigments present in these tumors have been proved to be both neuromelanin and oculocutaneous type of melanin.

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  • (PMID = 16758682.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Melanins
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22. Pantanowitz L, Galan A, Gang DL, Crisi GM, LaPolice P, Goulart RA: Diagnostic cytologic features of an epididymal melanotic neuroectodermal tumor of infancy present in scrotal fluid: a case report. Acta Cytol; 2006 Jul-Aug;50(4):460-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnostic cytologic features of an epididymal melanotic neuroectodermal tumor of infancy present in scrotal fluid: a case report.
  • BACKGROUND: The cytologic features of melanotic neuroectodermal tumor of infancy (MNTI) have been described in rare cases only, and these reports have been based solely on direct smears obtained from aspirated tumor material or from touch preparations of resected tumors.
  • CASE: We report, to our knowledge, the first documented case of an epididymal MNTI diagnosed from aspirated hydrocele fluid processed using the ThinPrep system (Cytyc Corp., Boxborough, Massachusetts, U.S.A.).
  • CONCLUSION: Based on a 15 year retrospective review of scrotal fluids submitted for cytologic evaluation to our laboratory, MNTI represented the sole neoplasm that was represented in the fluid and could be specifically diagnosed.
  • Compared to the direct smear evaluation in our case and other published reports, the ThinPrep method enables the recognition of both neuroblast-like cells and larger melanin-containing epithelial cells in scrotal fluid, thereby aiding in the specific diagnosis of MNTI and minimizing the risk of misdiagnosing this tumor as a more aggressive neoplasm.
  • [MeSH-major] Epididymis / pathology. Genital Diseases, Male / diagnosis. Genital Diseases, Male / pathology. Neuroectodermal Tumor, Melanotic / diagnosis. Neuroectodermal Tumor, Melanotic / pathology. Scrotum / pathology

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  • (PMID = 16901015.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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23. Nakanishi K, Hori H, Matsubara T, Matsuda K, Deguchi T, Komada Y: Recurrent melanotic neuroectodermal tumor in the orbit successfully treated with resection followed by pediculated periosteal flaps. Pediatr Blood Cancer; 2008 Sep;51(3):430-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recurrent melanotic neuroectodermal tumor in the orbit successfully treated with resection followed by pediculated periosteal flaps.
  • Melanotic neuroectodermal tumor of infancy (MNTI) is a rare tumor arising mainly in the orofacial bones.
  • We present a case of newborn with recurrent MNTI in the lateral wall of right orbit.
  • In this article, we describe clinical course of recurrent MNTI in the orbit and discuss management of the tumor involving the orbit.
  • [MeSH-major] Neuroectodermal Tumor, Melanotic / surgery. Orbital Neoplasms / surgery. Surgical Flaps

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 18493990.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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24. A da Fonseca M, Thikkurissy S: Maxillary melanotic neuroectodermal tumor of infancy. Int J Clin Pediatr Dent; 2009 Sep;2(3):61-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Maxillary melanotic neuroectodermal tumor of infancy.
  • The melanotic neuroectodermal tumor of infancy (MNTI) is a rare benign neoplasm of neural crest origin most commonly found in the anterior region of the maxilla.
  • The tumor almost always develops during the first year of life, although in some cases it can be present at birth.
  • MNTI's present as a rapidly growing, painless expansile, partly pigmented mass.
  • Malignant transformation has been noted in approximately 6.5% of all cases and in 2% of maxillary tumors.
  • The case of a 3-month old boy who presented with a loose primary maxillary left central incisor is discussed.
  • The diagnostic and clinico-pathological features as well as tumor management and importance of a timely diagnosis are reviewed.

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  • (PMID = 25206125.001).
  • [ISSN] 0974-7052
  • [Journal-full-title] International journal of clinical pediatric dentistry
  • [ISO-abbreviation] Int J Clin Pediatr Dent
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC4086571
  • [Keywords] NOTNLM ; Melanotic neuroectodermal tumor of infancy / maxilla / pediatric dentistry / pediatric oral pathology.
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25. Piperi EP, Rake SA, Tosios KI, Vasilopoulou EE, Rake AP, Sandler NA, Issacson T, Sklavounou A, Koutlas IG: Mandibular melanotic neuroectodermal tumor of infancy treated conservatively with enucleation. J Craniofac Surg; 2010 May;21(3):685-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mandibular melanotic neuroectodermal tumor of infancy treated conservatively with enucleation.
  • Melanotic neuroectodermal tumor of infancy (MNTI) is an uncommon, rapidly growing neoplasm of neural crest origin that primarily develops in the maxilla of infants during their first year of life.
  • In this study, we report a case of mandibular MNTI in a 4-month-old male patient that was conservatively treated with enucleation and curettage and has shown no recurrence 11 years after surgery.
  • Review of the English-language literature revealed that of more than 350 cases of MNTI reported so far, only 23, including the present one, have been encountered in the mandible.
  • In conclusion, MNTI lesions in the mandible, albeit rare, show high recurrence rate.
  • However, small-size mandibular MNTI lesions may be successfully treated with conservative enucleation.
  • [MeSH-major] Mandibular Neoplasms / surgery. Neuroectodermal Tumor, Melanotic / surgery

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  • (PMID = 20485029.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 24
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26. Di Rocco F, Roujeau T, Puget S, Peyre M, Zerah M: Slow-growing lambdoid melanotic neuroectodermal tumor of infancy. Eur J Pediatr; 2007 Jul;166(7):739-41

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Slow-growing lambdoid melanotic neuroectodermal tumor of infancy.
  • Melanotic neuroectodermal tumors of infancy are rare neoplasms that occasionally may involve the skull.
  • To illustrate this latter presentation, we present a case of a slowly growing melanotic neuroectodermal tumor of infancy located on the right lambdoid suture.
  • [MeSH-major] Cranial Sutures / pathology. Neuroectodermal Tumor, Melanotic / pathology. Skull Neoplasms / pathology

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  • [Cites] J Neurosurg. 1994 May;80(5):919-24 [8169635.001]
  • [Cites] Childs Nerv Syst. 1995 Mar;11(3):186-8 [7773982.001]
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  • (PMID = 17033805.001).
  • [ISSN] 0340-6199
  • [Journal-full-title] European journal of pediatrics
  • [ISO-abbreviation] Eur. J. Pediatr.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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27. Chen Y, Li TJ, Yu GY: [Diagnosis and management of oral melanotic neuroectodermal tumor of infancy]. Beijing Da Xue Xue Bao; 2008 Feb 18;40(1):19-23
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Diagnosis and management of oral melanotic neuroectodermal tumor of infancy].
  • OBJECTIVE: To investigate the clinicopathological features of oral melanotic neuroectodermal tumor of infancy (MNTI).
  • METHODS: We retrospectively reviewed the clinical and pathological data of 13 cases of oral MNTI treated in Peking University School and Hospital of Stomatology from 1980 to 2007.
  • The most common symptom of the disease was swelling.
  • Five tumors were found purple-reddish or blue-blackish.
  • The neoplasm grew rapidly.
  • Only 1 case was diagnosed as MNTI and 3 cases were diagnosed as malignant tumor before biopsy.
  • Two of 9 cases with follow-up information recurred in one month after surgery and 1 case dead of the tumor.
  • One case with remnants of tumor did not recur after 19 years postoperatively.
  • Special attention should be paid to the color of the tumor during intra-oral examination.
  • This tumor grew rapidly and invasively and the patients require close follow-up within the first 6 months postoperatively.
  • The pathologic differential diagnosis of MNTI should include other pediatric "small round cell" neoplasms.
  • [MeSH-major] Mouth Neoplasms. Neuroectodermal Tumor, Melanotic

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  • (PMID = 18278131.001).
  • [ISSN] 1671-167X
  • [Journal-full-title] Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences
  • [ISO-abbreviation] Beijing Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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28. Kruse-Lösler B, Gaertner C, Bürger H, Seper L, Joos U, Kleinheinz J: Melanotic neuroectodermal tumor of infancy: systematic review of the literature and presentation of a case. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2006 Aug;102(2):204-16
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Melanotic neuroectodermal tumor of infancy: systematic review of the literature and presentation of a case.
  • Melanotic neuroectodermal tumor of infancy (MNTI) is a rare, distinctive neoplasm of early infancy with rapid expansile growth and a high rate of recurrences.
  • The origin of the tumor is the neural crest.
  • The expansive, destructive, and rapid growth of MNTI and its effects on the surrounding tissues are the most obvious clinical features.
  • Microscopically, large polygonal epithelioid cells resembling melanocytes, with variable deposits of melanin, and smaller neuroblast-like round cells characterize MNTI.
  • The present review supplements another 140 published cases of MNTI up to 2004, including an original case report.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Neuroectodermal Tumor, Melanotic / pathology
  • [MeSH-minor] Humans. Infant. Male. Maxillary Neoplasms / pathology. Maxillary Neoplasms / surgery. Neoplasm Invasiveness. Neoplasm Recurrence, Local

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  • (PMID = 16876064.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 118
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29. Jeon HJ, Kong DS, Shin HJ: Melanotic neuroectodermal tumor of infancy: a case report. Childs Nerv Syst; 2008 Dec;24(12):1489-92

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Melanotic neuroectodermal tumor of infancy: a case report.
  • Melanotic neuroectodermal tumor of infancy (MNTI) is a rare pigmented tumor generally occurring in the head and neck region in children 12 months of age or younger.
  • Approximately 380 instances of this tumor are reported in the medical literature.
  • We presented a case of MNTI that occurred in the left temporal bone of a 2-month old female infant.
  • [MeSH-major] Neuroectodermal Tumor, Melanotic / surgery. Skull Neoplasms / surgery. Temporal Bone
  • [MeSH-minor] Antigens, Neoplasm / analysis. Female. Humans. Immunohistochemistry. Infant. Keratins / analysis. Melanoma-Specific Antigens. Neoplasm Proteins / analysis. Synaptophysin / analysis

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  • [Cites] Oral Surg Oral Med Oral Pathol. 1990 Jun;69(6):723-6 [2162511.001]
  • [Cites] Ann Diagn Pathol. 2004 Aug;8(4):207-12 [15290671.001]
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  • (PMID = 18704448.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins; 0 / Synaptophysin; 68238-35-7 / Keratins
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30. Antunes AC, Freitas RM, Oliveira PP, Rebouças RG: Melanotic neuroectodermal tumor of infancy: case report. Arq Neuropsiquiatr; 2005 Sep;63(3A):670-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Melanotic neuroectodermal tumor of infancy: case report.
  • INTRODUCTION: Melanotic neuroectodermal tumor of infancy (MNTI) is a rare tumor, locally aggressive, usually originated from maxilla and mandible and rarely from the skull.
  • A case of a 4 month-old child presenting a bulging lesion in the midline of the occipitoparietal region with progressive growth is reported.
  • Computerized tomography scan and magnetic resonance Image showed a highly enhancing tumor, dislocating anteriorly and inferiorly the superior sinuses.
  • CONCLUSION: Based on the absence of tumor recurrence, we believe in a favorable neurological prognosis and in a possible of cure, although the patient was not submitted to any adjuvant treatment.
  • [MeSH-major] Neuroectodermal Tumor, Melanotic / diagnosis. Skull Neoplasms / diagnosis

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  • (PMID = 16172721.001).
  • [ISSN] 0004-282X
  • [Journal-full-title] Arquivos de neuro-psiquiatria
  • [ISO-abbreviation] Arq Neuropsiquiatr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Brazil
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31. Hu X, Zhuge QY, Li YF, Pan CW, Tan F: [Application of double antibody sandwich ELISA for detection of nucleoside triphosphate hydrolase-II protein of Toxoplasma gondii]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi; 2010 Oct 30;28(5):343-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: Two hybridoma cell lines, MNTI and MNT2, were developed for secreting mAbs against rTgNTPase-II.

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  • (PMID = 21351545.001).
  • [ISSN] 1000-7423
  • [Journal-full-title] Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases
  • [ISO-abbreviation] Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Protozoan; EC 3.6.1.15 / Nucleoside-Triphosphatase
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32. Tan O, Atik B, Ugras S: Melanotic neuroectodermal tumor in a newborn. Int J Pediatr Otorhinolaryngol; 2005 Oct;69(10):1441-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Melanotic neuroectodermal tumor in a newborn.
  • Melanotic neuroectodermal tumor of infancy (MNTI) is an uncommon, fast-growing, pigmented neoplasm of neural crest origin; it primarily affects the maxilla of the infants during the first year of life.
  • Approximately 200 instances of this tumor are reported in the medical literature.
  • We present a case of newborn with MNTI on the left maxillary alveolar ridge.
  • The diagnostic features and management alternatives of MNTI are discussed.
  • [MeSH-major] Alveolar Process. Maxillary Neoplasms / surgery. Neuroectodermal Tumor, Melanotic / surgery

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  • (PMID = 15963575.001).
  • [ISSN] 0165-5876
  • [Journal-full-title] International journal of pediatric otorhinolaryngology
  • [ISO-abbreviation] Int. J. Pediatr. Otorhinolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Ireland
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33. Fowler DJ, Chisholm J, Roebuck D, Newman L, Malone M, Sebire NJ: Melanotic neuroectodermal tumor of infancy: clinical, radiological, and pathological features. Fetal Pediatr Pathol; 2006 Mar-Apr;25(2):59-72
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Melanotic neuroectodermal tumor of infancy: clinical, radiological, and pathological features.
  • We present a case of a 4-month-old female infant with a maxillary melanotic neuroectodermal tumor of infancy (MNTI) and review the pooled data from previous publications on this entity.
  • The literature to date comprises 378 reported cases from 1918 to the present, from which data on the presence or absence of metastatic disease was available in 311, and on the presence or absence of local recurrence in 165.
  • [MeSH-major] Maxillary Neoplasms / pathology. Maxillary Neoplasms / radiography. Neuroectodermal Tumor, Melanotic / pathology. Neuroectodermal Tumor, Melanotic / radiography
  • [MeSH-minor] Antigens, Neoplasm. Biomarkers, Tumor / analysis. Female. Humans. Immunohistochemistry. Infant. Keratins / analysis. Magnetic Resonance Imaging. Melanoma-Specific Antigens. Neoplasm Proteins / analysis. Treatment Outcome

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  • (PMID = 16908456.001).
  • [ISSN] 1551-3815
  • [Journal-full-title] Fetal and pediatric pathology
  • [ISO-abbreviation] Fetal Pediatr Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins; 68238-35-7 / Keratins
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34. Nazira B, Gupta H, Chaturvedi AK, Rao SA, Jena A: Melanotic neuroectodermal tumor of infancy: discussion of a case and a review of the imaging findings. Cancer Imaging; 2009;9:121-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Melanotic neuroectodermal tumor of infancy: discussion of a case and a review of the imaging findings.
  • Melanotic neuroectodermal tumor of infancy (MNTI) is an uncommon melanin-containing mesenchymal tumor of neural crest origin.
  • What make this tumor unique and interesting is its characteristic predilection for anterior maxilla (premaxilla) and the presence of pigment melanin which gives the tumor distinct clinicopathological, immunohistochemical, ultrastructural and imaging features.
  • Although first described almost a century ago, to the authors' knowledge, only a few hundred cases of MNTI have been reported worldwide in the English medical literature.
  • We document a case of MNTI and describe the imaging findings with intent to contribute to its small but accruing radiological data.
  • [MeSH-major] Magnetic Resonance Imaging. Maxillary Neoplasms / pathology. Neuroectodermal Tumor, Melanotic / pathology. Tomography, Spiral Computed
  • [MeSH-minor] Antigens, CD57 / analysis. Antigens, Neoplasm / analysis. Biomarkers, Tumor / analysis. Biopsy, Needle. Diagnosis, Differential. Glial Fibrillary Acidic Protein / analysis. Humans. Infant. Keratins / analysis. Male. Melanoma-Specific Antigens. Mucin-1 / analysis. Neoplasm Proteins / analysis. Phosphopyruvate Hydratase / analysis. Synaptophysin / analysis

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  • [Cites] Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002 Jun;93(6):688-98 [12142876.001]
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  • (PMID = 20080455.001).
  • [ISSN] 1470-7330
  • [Journal-full-title] Cancer imaging : the official publication of the International Cancer Imaging Society
  • [ISO-abbreviation] Cancer Imaging
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD57; 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Glial Fibrillary Acidic Protein; 0 / Melanoma-Specific Antigens; 0 / Mucin-1; 0 / Neoplasm Proteins; 0 / Synaptophysin; 68238-35-7 / Keratins; EC 4.2.1.11 / Phosphopyruvate Hydratase
  • [Number-of-references] 25
  • [Other-IDs] NLM/ PMC2821590
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35. Lacy SR, Kuhar M: Melanotic neuroectodermal tumor of infancy presenting in the subcutaneous soft tissue of the thigh. Am J Dermatopathol; 2010 May;32(3):282-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Melanotic neuroectodermal tumor of infancy presenting in the subcutaneous soft tissue of the thigh.
  • Melanotic neuroectodermal tumor of infancy (MNTI) is a rare and diagnostically challenging neoplasm typically presenting in the bones of the maxilla, skull, or mandible.
  • We describe a case of MNTI presenting as a palpable, subcutaneous, thigh mass in a 5-month-old girl.
  • Microscopically, the tumor consisted of nested foci of primitive-appearing small round blue cells with an increased nuclear to cytoplasmic ratio, stippled chromatin, and occasional mitotic figures.
  • A larger and more epithelioid second cell population exhibited eosinophilic cytoplasm and sparse pigmented granules.
  • The differential diagnosis of soft tissue MNTI can include melanoma, neuroblastoma, rhabdomyosarcoma, desmoplastic small round cell tumor, and other pediatric "small round cell" neoplasms.
  • The tumor had the characteristic immunophenotype of MNTI: cytokeratin+, HMB-45+, neuron-specific enolase+, and synaptophysin+.
  • MNTI should be considered in the differential diagnosis of pigmented soft tissue lesions in children.
  • Our patient remains disease-free 40 months after excision, although these tumors can locally recur (10%-20%) and rarely metastasize.
  • [MeSH-major] Neuroectodermal Tumor, Melanotic / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Carcinoma, Small Cell / diagnosis. Diagnosis, Differential. Female. Humans. Infant. Melanoma / diagnosis. Neuroblastoma / diagnosis. Rhabdomyosarcoma / diagnosis. Thigh. Treatment Outcome

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  • (PMID = 20010403.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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36. Ahmed HU, Arya M, Muneer A, Mushtaq I, Sebire NJ: Testicular and paratesticular tumours in the prepubertal population. Lancet Oncol; 2010 May;11(5):476-83
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Testicular and paratesticular tumours in the prepubertal population.
  • Prepubertal testicular and paratesticular tumours are a rare group of tumours, distinct from postpubertal paediatric and adult tumours of this region.
  • Tumours within this group are testicular germ-cell tumours (such as benign teratoma, epidermoid cyst and malignant yolk-sac tumours) and stromal tumours (such as juvenile granulosa-cell, Leydig-cell, and Sertoli-cell tumours).
  • Paratesticular tumours can be benign (lipoma, leiomyoma, haemangioma) or malignant (rhabdomyosarcoma, melanotic neuroectodermal tumour of infancy).
  • Because of their rarity, centralised pathology and treatment, and national collaborative clinical trials have been important in establishing the optimum management of malignant tumours in this group.
  • We provide an up-to-date and comprehensive review of the clinical presentation, imaging, pathology, and clinical management of prepubertal paratesticular and testicular tumours.
  • [MeSH-minor] Child. Combined Modality Therapy. Humans. Male. Neoplasm Staging. Neoplasms, Germ Cell and Embryonal / diagnosis. Neoplasms, Germ Cell and Embryonal / epidemiology. Neoplasms, Germ Cell and Embryonal / therapy. Sex Cord-Gonadal Stromal Tumors / diagnosis. Sex Cord-Gonadal Stromal Tumors / epidemiology. Sex Cord-Gonadal Stromal Tumors / therapy. Testicular Neoplasms / diagnosis. Testicular Neoplasms / epidemiology. Testicular Neoplasms / therapy

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  • [Copyright] 2010 Elsevier Ltd. All rights reserved.
  • [CommentIn] Lancet Oncol. 2010 Sep;11(9):814 [20816371.001]
  • (PMID = 20434716.001).
  • [ISSN] 1474-5488
  • [Journal-full-title] The Lancet. Oncology
  • [ISO-abbreviation] Lancet Oncol.
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / G0701302; United Kingdom / Medical Research Council / / G1002509
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Number-of-references] 62
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37. Neven J, Hulsbergen-van der Kaa C, Groot-Loonen J, de Wilde PC, Merkx MA: Recurrent melanotic neuroectodermal tumor of infancy: a proposal for treatment protocol with surgery and adjuvant chemotherapy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2008 Oct;106(4):493-6
Hazardous Substances Data Bank. VINCRISTINE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recurrent melanotic neuroectodermal tumor of infancy: a proposal for treatment protocol with surgery and adjuvant chemotherapy.
  • The case of a 4-month-old male infant treated with combined surgery and chemotherapy for an aggressive recurrent melanotic neuroectodermal tumor of infancy (MNTI) on the top of the alveolar process of the mandible with a long-term follow-up is presented.
  • The reason for this protocol was because molecular genetic studies of this tumor showed loss of heterozygosity of chromosome 1p and gain of chromosome 7q analogue to neuroblastomas.
  • A combination of surgery and chemotherapy should be the preferred treatment in case of a recurrence MNTI because optimal functional and aesthetic outcome.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Mandibular Neoplasms / drug therapy. Mandibular Neoplasms / surgery. Neuroectodermal Tumor, Melanotic / drug therapy. Neuroectodermal Tumor, Melanotic / surgery
  • [MeSH-minor] Carboplatin / administration & dosage. Chemotherapy, Adjuvant. Chromosomes, Human, Pair 1. Chromosomes, Human, Pair 7. Comparative Genomic Hybridization. Etoposide / administration & dosage. Humans. Ifosfamide / administration & dosage. Infant. Loss of Heterozygosity. Male. Neoplasm Recurrence, Local. Vincristine / administration & dosage

  • Hazardous Substances Data Bank. ETOPOSIDE .
  • Hazardous Substances Data Bank. IFOSFAMIDE .
  • Hazardous Substances Data Bank. CARBOPLATIN .
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  • (PMID = 18602297.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 6PLQ3CP4P3 / Etoposide; BG3F62OND5 / Carboplatin; UM20QQM95Y / Ifosfamide; CEV regimen
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38. Oda D: Soft-tissue lesions in children. Oral Maxillofac Surg Clin North Am; 2005 Nov;17(4):383-402

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Diseases discussed include reactive gingival swelling, generalized gingival fibromatosis, melanotic neuroectodermal tumor of infancy, fibromas, vascular lesions, salivary gland lesions, and infantile rhabdomyomas.

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  • (PMID = 18088794.001).
  • [ISSN] 1042-3699
  • [Journal-full-title] Oral and maxillofacial surgery clinics of North America
  • [ISO-abbreviation] Oral Maxillofac Surg Clin North Am
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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39. Kumari TP, Venugopal M, Mathews A, Kusumakumary P: Effectiveness of chemotherapy in melanotic neurectodermal tumor of infancy. Pediatr Hematol Oncol; 2005 Apr-May;22(3):199-206

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effectiveness of chemotherapy in melanotic neurectodermal tumor of infancy.
  • MNTI is an uncommon tumor mainly of infants.
  • Chemotherapy has been tried for recurrent/residual tumors.
  • In 2 of them complete residual tumor resection became possible; 2 of them are alive and tumor regression continues.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Neoplasm, Residual / drug therapy. Neuroectodermal Tumor, Melanotic / drug therapy. Orbital Neoplasms / drug therapy. Skull Neoplasms / drug therapy. Temporal Bone / pathology
  • [MeSH-minor] Female. Humans. Infant. Male. Neoplasm Recurrence, Local. Pigmentation. Treatment Outcome

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  • (PMID = 16020102.001).
  • [ISSN] 0888-0018
  • [Journal-full-title] Pediatric hematology and oncology
  • [ISO-abbreviation] Pediatr Hematol Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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40. Selim H, Shaheen S, Barakat K, Selim AA: Melanotic neuroectodermal tumor of infancy: review of literature and case report. J Pediatr Surg; 2008 Jun;43(6):E25-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Melanotic neuroectodermal tumor of infancy: review of literature and case report.
  • Melanotic neuroectodermal tumor of infancy (MNTI) is an uncommon, fast-growing, pigmented neoplasm of neural crest origin.
  • Approximately, a few hundred of these tumors have been reported in medical literature.
  • We present a case of a newborn with MNTI involving the anterior maxillary region.
  • The diagnostic features and management alternatives of MNTI are discussed.
  • [MeSH-major] Maxillary Neoplasms / diagnosis. Maxillary Neoplasms / surgery. Neuroectodermal Tumor, Melanotic / diagnosis. Neuroectodermal Tumor, Melanotic / surgery. Surgery, Oral / methods

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  • (PMID = 18558161.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 15
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41. Eckardt AM, Barth EL, Berten J, Gellrich NC: Pediatric mandibular resection and reconstruction: long-term results with autogenous rib grafts. Craniomaxillofac Trauma Reconstr; 2010 Mar;3(1):25-32

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Reconstruction of mandibular defects following tumor resection in infants is a particular challenge.
  • Although autogenous rib grafts have no relevance in the restoration of mandibular bone defects occurring after ablative tumor surgery due to limited bone stock and the availability of other donor areas, they are a useful surgical alternative following tumor surgery in infants.
  • We here report on a 2, 5, 8, and 15-year follow-up of four children who were diagnosed with benign tumors of the mandible with osseous destruction at the age of 4, 6, 15, and 18 months, respectively.
  • Histologic diagnoses were melanotic neuroectodermal tumor (n = 2), hemangioendothelioma of the mandible (n = 1), and ameloblastoma (n = 1).

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  • (PMID = 22110815.001).
  • [ISSN] 1943-3883
  • [Journal-full-title] Craniomaxillofacial trauma & reconstruction
  • [ISO-abbreviation] Craniomaxillofac Trauma Reconstr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3052664
  • [Keywords] NOTNLM ; Mandibular reconstruction / bone graft / facial growth / pediatric maxillofacial tumor / rib graft
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42. Eckardt A, Swennen G, Brachvogel P: [Autologous rib graft for restoration of continuity defects of the mandible]. Mund Kiefer Gesichtschir; 2005 Mar;9(2):66-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Reconstruction of mandibular defects following tumor resection in infants is a particular challenge.
  • Although autologous rib grafts have no relevance nowadays for restoration of mandibular bone defects following ablative tumor surgery due to limited bone stock and the availability of other donor areas, they are a useful surgical alternative following tumor surgery in infants.
  • PATIENTS AND METHOD: We here report on the 5- and 10-year follow-up of two children who were diagnosed with benign tumors of the mandible with osseous destruction at the age of 4 and 6 months, respectively.
  • Histological diagnoses were melanotic neuroectodermal tumor and hemangioendothelioma of the mandible.
  • [MeSH-major] Bone Transplantation / methods. Hemangioendothelioma / surgery. Mandible / surgery. Mandibular Neoplasms / surgery. Neuroectodermal Tumor, Melanotic / surgery

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  • [Cites] J Craniofac Surg. 2001 Jul;12(4):349-54 [11482619.001]
  • [Cites] Plast Reconstr Surg. 1972 Sep;50(3):270-4 [5050787.001]
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  • (PMID = 15685458.001).
  • [ISSN] 1432-9417
  • [Journal-full-title] Mund-, Kiefer- und Gesichtschirurgie : MKG
  • [ISO-abbreviation] Mund Kiefer Gesichtschir
  • [Language] ger
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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43. Lambropoulos V, Neofytou A, Sfougaris D, Mouravas V, Petropoulos A: Melanotic neuroectodermal tumor of infancy (MNT1) arising in the skull. Short review of two cases. Acta Neurochir (Wien); 2010 May;152(5):869-75
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Melanotic neuroectodermal tumor of infancy (MNT1) arising in the skull. Short review of two cases.
  • INTRODUCTION: Melanotic neuroectodermal tumor of infancy (MNT1) is a rare congenital pigmented neoplasm of neural crest origin, locally aggressive, and rapidly growing that develops during the first year of life.
  • CONCLUSION: Melanotic neuroectodermal tumor of infancy should be included in the differential diagnosis of skull lesions in infants.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Neuroectodermal Tumor, Melanotic / pathology. Skull / pathology. Skull Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Biomarkers, Tumor / metabolism. Biopsy. Combined Modality Therapy / methods. Combined Modality Therapy / standards. Diagnosis, Differential. Humans. Immunohistochemistry / methods. Infant. Male. Neoplasm Invasiveness / pathology. Neoplasm Invasiveness / physiopathology. Neoplasm Invasiveness / prevention & control. Neoplasm Recurrence, Local / prevention & control. Neurosurgical Procedures / methods. Radiotherapy / methods. Radiotherapy / standards. Stem Cells / metabolism. Stem Cells / pathology

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  • (PMID = 19669690.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Randomized Controlled Trial; Review
  • [Publication-country] Austria
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 60
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44. Omodaka S, Saito R, Kumabe T, Kawagishi J, Jokura H, Sonoda Y, Watanabe M, Kayama T, Tominaga T: Melanotic neuroectodermal tumor of the brain recurring 12 years after complete remission: case report. Brain Tumor Pathol; 2010 Apr;27(1):51-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Melanotic neuroectodermal tumor of the brain recurring 12 years after complete remission: case report.
  • We describe a rare case of melanotic neuroectodermal tumor (MNT) of the brain recurring 12 years after complete remission.
  • Magnetic resonance (MR) imaging revealed an intracranial extraaxial large tumor at the midfrontal region.
  • T(1)-weighted MR imaging showed the tumor to be well delineated with homogeneous enhancement by gadolinium.
  • The tumor was subtotally removed, and the histological diagnosis was MNT.
  • The residual tumor became enlarged, so gamma knife radiosurgery was performed 5 months after initial surgery.
  • This tumor was subtotally removed.
  • [MeSH-major] Brain Neoplasms / surgery. Neoplasm Recurrence, Local. Neuroectodermal Tumor, Melanotic / surgery. Remission Induction
  • [MeSH-minor] Biomarkers, Tumor / analysis. Child. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Radiosurgery. Time Factors

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  • (PMID = 20425049.001).
  • [ISSN] 1861-387X
  • [Journal-full-title] Brain tumor pathology
  • [ISO-abbreviation] Brain Tumor Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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45. Eckardt A, Swennen G, Barth EL, Brachvogel P: Long-term results after mandibular continuity resection in infancy: the role of autogenous rib grafts for mandibular restoration. J Craniofac Surg; 2006 Mar;17(2):255-60
MedlinePlus Health Information. consumer health - Plastic and Cosmetic Surgery.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-term results after mandibular continuity resection in infancy: the role of autogenous rib grafts for mandibular restoration.
  • Reconstruction of mandibular defects after tumor resection in infants is a particular challenge.
  • Although autogenous rib grafts have no relevance nowadays for restoration of mandibular bone defects after ablative tumor surgery because of limited bone stock and the availability of other donor areas, they are a useful surgical alternative after tumor surgery in infants.
  • We here report on a 6-month, 5-year, and 10-year follow-up of three children who were diagnosed with benign tumors of the mandible with osseous destruction at the ages of 4 months, 6 months, and 2 years, respectively.
  • Histologic diagnoses were melanotic neuroectodermal tumor, hemangioendothelioma of the mandible, and ameloblastoma.
  • [MeSH-minor] Ameloblastoma / rehabilitation. Ameloblastoma / surgery. Child, Preschool. Female. Follow-Up Studies. Hemangioendothelioma / rehabilitation. Hemangioendothelioma / surgery. Humans. Infant. Male. Maxillofacial Development. Neuroectodermal Tumor, Melanotic / rehabilitation. Neuroectodermal Tumor, Melanotic / surgery. Ribs / transplantation

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  • (PMID = 16633171.001).
  • [ISSN] 1049-2275
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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46. Al-Otaibi M, Lach B, Al Shail E: December 2004: one-year-old girl with aggressive skull tumor. Brain Pathol; 2005 Apr;15(2):171-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] December 2004: one-year-old girl with aggressive skull tumor.
  • December 2004. Twelve-month old girl presented with recurrent subcutaneous lesion in the left parietal region, one year after excision of a "benign" tumor.
  • An MRI demonstrated left temporo-parietal skull tumor infiltrating the soft tissue, surrounding craniotomy flap, and extending to the brain parenchyma.
  • Biopsy revealed biphasic neoplasm displaying nests of poorly differentiated neuroblastic cells positive for synaptophysin and pigmented cuboidal epithelioid cell positive for keratins, epithelial membrane antigen and MHB-45.
  • Interestingly, cell with the neuroblastic immunophenotype displayed 80% nuclear MIB-1 reactivity indicating that the aggressiveness of the neoplasm was confined mostly to this pattern of differentiation.
  • The overall histological features are consistent with a rare malignant variant of a melanotic neuroectodermal tumor of infancy.
  • [MeSH-major] Neoplasm Recurrence, Local / pathology. Neuroectodermal Tumor, Melanotic / pathology. Parietal Bone / pathology. Skull Neoplasms / pathology

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  • (PMID = 15912891.001).
  • [ISSN] 1015-6305
  • [Journal-full-title] Brain pathology (Zurich, Switzerland)
  • [ISO-abbreviation] Brain Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Switzerland
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47. Koral K, Derinkuyu B, Timmons C, Schwartz-Dabney CL, Swift D: Melanotic neuroectodermal tumor of infancy: report of one calvarial lesion with T1 shortening and one maxillary lesion. Clin Imaging; 2010 Sep-Oct;34(5):382-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Melanotic neuroectodermal tumor of infancy: report of one calvarial lesion with T1 shortening and one maxillary lesion.
  • Melanotic neuroectodermal tumor of infancy (MNTI) is a rare tumor which commonly involves the mandible, maxilla and calvarium.
  • We report two infants with this rare tumor.
  • T1 shortening due to melanin content has been rarely described in MNTI.
  • The calvarial MNTI showed T1 shortening which was helpful in diagnosis.
  • [MeSH-major] Magnetic Resonance Imaging / methods. Maxillary Neoplasms / diagnosis. Neuroectodermal Tumor, Melanotic / diagnosis. Skull Neoplasms / diagnosis. Tomography, X-Ray Computed / methods

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  • (PMID = 20813304.001).
  • [ISSN] 1873-4499
  • [Journal-full-title] Clinical imaging
  • [ISO-abbreviation] Clin Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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48. Michelow P, Meyers T, Dubb M, Wright C: The utility of fine needle aspiration in HIV positive children. Cytopathology; 2008 Apr;19(2):86-93
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To determine the spectrum of disease, diagnostic accuracy and adequacy of fine needle aspirates (FNA) in human immunodeficiency virus (HIV) positive children who present with mass lesions.
  • Groin masses were aspirated in six children, flank and abdominal masses in four children, buttock masses in three children, a chest wall mass in one child and a sonar guided FNA of a lung mass in one child.
  • There was one case each of nephroblastoma, rhabdomyosarcoma, myeloma, melanotic progonoma and spindle cells, not otherwise specified.


49. Suzuki C, Maeda M, Matsushima N, Takamura M, Matsubara T, Taki W, Takeda K: Melanotic neuroectodermal tumor of infancy in the skull: CT and MRI features. J Neuroradiol; 2007 Jul;34(3):212-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Melanotic neuroectodermal tumor of infancy in the skull: CT and MRI features.
  • [MeSH-major] Neuroectodermal Tumor, Melanotic / pathology. Neuroectodermal Tumor, Melanotic / radiography. Skull Neoplasms / pathology. Skull Neoplasms / radiography

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  • (PMID = 17582497.001).
  • [ISSN] 0150-9861
  • [Journal-full-title] Journal of neuroradiology. Journal de neuroradiologie
  • [ISO-abbreviation] J Neuroradiol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] France
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50. Gupta N, Kumar V, Srinivasan R, Nijhawan R, Rajwanshi A: Cytomorphological variation in two cases of melanotic neuroectodermal tumor of infancy. Diagn Cytopathol; 2005 Jan;32(1):58-60

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytomorphological variation in two cases of melanotic neuroectodermal tumor of infancy.
  • [MeSH-major] Biopsy, Fine-Needle / methods. Maxillary Neoplasms / pathology. Neuroectodermal Tumor, Melanotic / pathology

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  • (PMID = 15584044.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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51. Saleem S, Altinok D: Melanotic neuroectodermal tumor of the calvarium. Pediatr Radiol; 2010 Dec;40 Suppl 1:S159
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Melanotic neuroectodermal tumor of the calvarium.
  • [MeSH-major] Magnetic Resonance Imaging. Neuroectodermal Tumor, Melanotic / diagnosis. Skull / diagnostic imaging. Skull / pathology. Skull Neoplasms / diagnosis. Tomography, X-Ray Computed

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  • [Cites] Radiographics. 2009 Sep-Oct;29(5):1503-24 [19755608.001]
  • (PMID = 20574653.001).
  • [ISSN] 1432-1998
  • [Journal-full-title] Pediatric radiology
  • [ISO-abbreviation] Pediatr Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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52. Nelson BL, Thompson LD: Melanotic neuroectodermal tumor of infancy. Ear Nose Throat J; 2006 Jun;85(6):365
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Melanotic neuroectodermal tumor of infancy.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Neuroectodermal Tumor, Melanotic / pathology

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  • (PMID = 16866106.001).
  • [ISSN] 0145-5613
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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53. Agoumi M, Al Dhaybi R, Powell J, Brochu P, Lapointe A, Kokta V: Rapidly growing gingival mass in an infant--quiz case. Melanotic neuroectodermal tumor of infancy (MNTI). Arch Dermatol; 2010 Mar;146(3):337-42

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Rapidly growing gingival mass in an infant--quiz case. Melanotic neuroectodermal tumor of infancy (MNTI).
  • [MeSH-major] Gingival Neoplasms / diagnosis. Neuroectodermal Tumor, Melanotic / diagnosis
  • [MeSH-minor] Biopsy. Diagnosis, Differential. Disease Progression. Humans. Immunohistochemistry. Infant. Male. Phosphopyruvate Hydratase / metabolism

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  • (PMID = 20231510.001).
  • [ISSN] 1538-3652
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 4.2.1.11 / Phosphopyruvate Hydratase
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54. Gonçalves CF, Costa Ndo L, Oliveira-Neto HH, Jesus LA, Sant'Ana SS, Leles JL, Silva MA, Mendonça EF, Batista AC: Melanotic neuroectodermal tumor of infancy: report of 2 cases. J Oral Maxillofac Surg; 2010 Sep;68(9):2341-6
The Weizmann Institute of Science GeneCards and MalaCards databases. gene/protein/disease-specific - MalaCards for melanotic neuroectodermal tumor .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Melanotic neuroectodermal tumor of infancy: report of 2 cases.
  • [MeSH-major] Maxillary Neoplasms / pathology. Neuroectodermal Tumor, Melanotic / pathology

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  • (PMID = 20646814.001).
  • [ISSN] 1531-5053
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / S100 Proteins
  • [Number-of-references] 32
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