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6. Sham E, Leong J, Maher R, Schenberg M, Leung M, Mansour AK: Mandibular ameloblastoma: clinical experience and literature review. ANZ J Surg; 2009 Oct;79(10):739-44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Ameloblastoma is a locally aggressive odontogenic tumour of the mandible and maxilla that, if neglected, can cause severe facial disfigurement and functional impairment.
  • Two tumours involved the angle and posterior body of the mandible, one the angle and ramus, one the body and two the anterior mandibular.

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  • (PMID = 19878171.001).
  • [ISSN] 1445-2197
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Australia
  • [Number-of-references] 42
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7. Wit MA, de Vos-van Biezenbos JB, de Boe JR: [A drooping face; the importance of family history in children with recurrent peripheral facial palsy]. Ned Tijdschr Geneeskd; 2007 Feb 10;151(6):364-6
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  • [Transliterated title] Een scheef gezicht; het belang van de familieanamnese bij kinderen en jongeren met een recidiverende perifere aangezichtsverlamming.
  • After excluding Lyme borreliosis and cerebellopontine angle tumour, a diagnosis of idiopathic familial peripheral facial palsy was made.

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  • (PMID = 17352302.001).
  • [ISSN] 0028-2162
  • [Journal-full-title] Nederlands tijdschrift voor geneeskunde
  • [ISO-abbreviation] Ned Tijdschr Geneeskd
  • [Language] dut
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Netherlands
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8. Millodot M, Hendler K, Pe'er J: Iris melanoma: a case report and review. Ophthalmic Physiol Opt; 2006 Jan;26(1):120-6
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  • Iris melanoma is a rare ocular tumour, which can be detected early in its development.
  • This tumour is almost always unilateral and arises usually from a pre-existing naevus.
  • It was found that a tumour had spread throughout the iris stroma and invaded the anterior chamber angle.
  • Although enucleation would have been the treatment of choice in the past, the trend today in the treatment of a growing, large circumscribed iris tumour is to excise it.

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  • (PMID = 16390492.001).
  • [ISSN] 0275-5408
  • [Journal-full-title] Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)
  • [ISO-abbreviation] Ophthalmic Physiol Opt
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 53
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9. Szabo B, Szabo I, Mera M, Fripcea AM: [Keratotic basal cell carcinoma with orbital extension--case report]. Oftalmologia; 2005;49(2):43-9
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  • This is a description of a case of a 72-year-old female who developed a basal cell carcinoma of the external angle of the eyelid, with intraorbital extension.
  • The tumour of the eyelid and orbit was completely removed with good postoperative course and a good outcome without recurrence in the past 3 years.

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  • (PMID = 16245743.001).
  • [ISSN] 1220-0875
  • [Journal-full-title] Oftalmologia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Oftalmologia
  • [Language] rum
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Romania
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10. Preuss SF, Wittekindt C, Klussmann JP, Guntinas-Lichius O, Beutner D, Reineck S, Hüttenbrink KB: [Indolent neck tumour. A 47 year old patient with a painless tumour in the area of the left mandibular angle]. HNO; 2005 Oct;53(10):876-8
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  • [Title] [Indolent neck tumour. A 47 year old patient with a painless tumour in the area of the left mandibular angle].
  • [Transliterated title] Indolenter Halstumor. 47-jährige Patientin mit schmerzlosem Tumor im Bereich des linken Kieferwinkels.

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  • [Cites] Hum Pathol. 1999 Dec;30(12):1464-73 [10667425.001]
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  • (PMID = 15703880.001).
  • [ISSN] 0017-6192
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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11. Sánchez-Legaza E, Meléndez Guerrero B, Sánchez Legaza B, Idelfonso Miranda J: [Acoustic neurinoma shown as a facial palsy]. An Otorrinolaringol Ibero Am; 2007;34(6):565-72
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  • Acoustic neurinoma is the most frequent benign tumour at the cerebellopontile angle.

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  • (PMID = 18293776.001).
  • [ISSN] 0303-8874
  • [Journal-full-title] Anales otorrinolaringológicos ibero-americanos
  • [ISO-abbreviation] An Otorrinolaringol Ibero Am
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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12. Lee SH, Rhee BA, Choi SK, Koh JS, Lim YJ: Cerebellopontine angle tumors causing hemifacial spasm: types, incidence, and mechanism in nine reported cases and literature review. Acta Neurochir (Wien); 2010 Nov;152(11):1901-8
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  • [Title] Cerebellopontine angle tumors causing hemifacial spasm: types, incidence, and mechanism in nine reported cases and literature review.
  • OBJECTIVE: Although hemifacial spasm is usually caused by vascular compression around the root exit zone of the facial nerve, it is sometimes brought on by a cerebellopontine angle tumor.
  • We reviewed and analyzed data from past experience with hemifacial spasm induced by cerebellopontine angle tumors.
  • METHODS: Nine patients of a total 2,050, who had presented with hemifacial spasms associated with cerebellopontine angle tumors between 1986 and 2009, were reviewed.
  • With respect to the pathogenesis of hemifacial spasms, offending vessels were found in six patients, tumor encasement of the facial nerve in one patient, hypervascular tumor compression of the facial nerve without offending vessels in one patient, and a huge tumor compressing the brain stem and, thus, contralateral facial nerve compression in one patient.
  • Hemifacial spasm was resolved in seven patients, whereas in two patients with a vestibular schwannoma and an epidermoid tumor, it improved transiently and then recurred in a month.
  • CONCLUSIONS: Each type of tumor had different characteristics with respect to the induction of hemifacial spasm; therefore, it is suggested that neurosurgeons, who are planning surgeries both for the purposes of relieving hemifacial spasm and removal of cerebellopontine angle tumor, should thoroughly prepare appropriate approaches and specific dissecting strategies according to each causative lesion.

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  • (PMID = 20845049.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Austria
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13. Rouleau V, Tahery J, Rod J, Louis Y, Galateau-Sallé F, Babin E: Inflammatory myofibroblastic tumour of the left mandibular angle. J Otolaryngol; 2006 Jun;35(3):202-4
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  • [Title] Inflammatory myofibroblastic tumour of the left mandibular angle.

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  • (PMID = 16930001.001).
  • [ISSN] 0381-6605
  • [Journal-full-title] The Journal of otolaryngology
  • [ISO-abbreviation] J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
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4. Sharifi G, Jahanbakhshi A, Sabeti S: A large choroid plexus papilloma removed by the cerebellomedullary fissure approach. Case report and review of the literature. Turk Neurosurg; 2008 Jul;18(3):302-6
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  • The tumour was removed by microsurgical dissection of the cerebellomedullary fissure.
  • [MeSH-major] Cerebellopontine Angle / surgery. Fourth Ventricle / surgery. Neurosurgical Procedures / methods. Papilloma, Choroid Plexus / surgery

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  • (PMID = 18814123.001).
  • [ISSN] 1019-5149
  • [Journal-full-title] Turkish neurosurgery
  • [ISO-abbreviation] Turk Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Turkey
  • [Number-of-references] 15
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15. Andrä J, Howe J, Garidel P, Rössle M, Richter W, Leiva-León J, Moriyon I, Bartels R, Gutsmann T, Brandenburg K: Mechanism of interaction of optimized Limulus-derived cyclic peptides with endotoxins: thermodynamic, biophysical and microbiological analysis. Biochem J; 2007 Sep 1;406(2):297-307
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  • For an understanding of the mechanisms of action, we performed a detailed physicochemical and biophysical analysis of the interaction of rough mutant LPS with these peptides by applying FTIR (Fourier-transform infrared) spectroscopy, SAXS (small-angle X-ray scattering), calorimetric techniques [DSC (differential scanning calorimetry) and ITC (isothermal titration calorimetry)] and FFTEM (freeze-fracture transmission electron microscopy).
  • This can be directly correlated with the inhibition of the LPS-induced production of tumour necrosis factor alpha in human mononuclear cells, but not with the action of the peptides on bacteria.

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  • (PMID = 17501719.001).
  • [ISSN] 1470-8728
  • [Journal-full-title] The Biochemical journal
  • [ISO-abbreviation] Biochem. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Antimicrobial Cationic Peptides; 0 / Arthropod Proteins; 0 / Endotoxins; 0 / Invertebrate Hormones; 0 / Lipopolysaccharides; 0 / Liposomes; 0 / Peptides, Cyclic; 0 / Phospholipids; 0 / antilipopolysaccharide factor (Limulus)
  • [Other-IDs] NLM/ PMC1948972
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16. Sparaco M, Morelli L, Piscioli I, Donato S, Catalucci A, Licci S: Primary myxopapillary ependymoma of the cerebellopontine angle: report of a case. Neurosurg Rev; 2009 Apr;32(2):241-4; discussion 244
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  • [Title] Primary myxopapillary ependymoma of the cerebellopontine angle: report of a case.
  • We describe a myxopapillary ependymoma located in the left cerebellopontine angle of a young man suffering from peripheral vertigo and left sensorineural hearing loss for years.
  • The patient underwent surgical removal of the tumour.
  • [MeSH-major] Cerebellar Neoplasms / diagnosis. Cerebellopontine Angle. Ependymoma / diagnosis

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  • [ISSN] 1437-2320
  • [Journal-full-title] Neurosurgical review
  • [ISO-abbreviation] Neurosurg Rev
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  • [Publication-type] Case Reports; Journal Article
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17. O'Brien DF, Crooks D, Mallucci C, Javadpour M, Williams D, du Plessis D, Broome J, Foy P, Pizer B: Meningeal melanocytoma. Childs Nerv Syst; 2006 Jun;22(6):556-61
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  • BACKGROUND: Meningeal melanocytoma was first described over 30 years ago as a benign tumour derived from melanocytes.
  • Although classified as a benign tumour, this tumour shows a marked tendency towards reduced survival following subtotal resection and transformation over time in a limited number to malignant melanoma.
  • Its classification as a benign tumour should be revised, given the published 5-year survival data.
  • ILLUSTRATIVE CASE: We report a fatal case of meningeal melanocytoma in the cerebello-pontine angle in a 10-year-old child.

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  • (PMID = 16491422.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
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18. Sriganesh K, Ramesh VJ, Veena S, Chandramouli BA: Dexmedetomidine for awake fibreoptic intubation and awake self-positioning in a patient with a critically located cervical lesion for surgical removal of infra-tentorial tumour. Anaesthesia; 2010 Sep;65(9):949-51
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  • [Title] Dexmedetomidine for awake fibreoptic intubation and awake self-positioning in a patient with a critically located cervical lesion for surgical removal of infra-tentorial tumour.
  • We describe how the use of dexmedetomidine for sedation during awake fibreoptic intubation also facilitated self-positioning before surgery in a patient with a cervical cord compressive lesion and raised intracranial pressure undergoing excision of a cerebellopontine angle lesion in the lateral position, without any adverse neurological outcome.

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  • [Copyright] © 2010 The Authors. Journal compilation © 2010 The Association of Anaesthetists of Great Britain and Ireland.
  • (PMID = 20569247.001).
  • [ISSN] 1365-2044
  • [Journal-full-title] Anaesthesia
  • [ISO-abbreviation] Anaesthesia
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Hypnotics and Sedatives; 67VB76HONO / Dexmedetomidine
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19. Greenberg JI, Shields DJ, Barillas SG, Acevedo LM, Murphy E, Huang J, Scheppke L, Stockmann C, Johnson RS, Angle N, Cheresh DA: A role for VEGF as a negative regulator of pericyte function and vessel maturation. Nature; 2008 Dec 11;456(7223):809-13
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  • Finally, genetic deletion of tumour cell VEGF disrupts PDGF-Rbeta/VEGF-R2 complex formation and increases tumour vessel maturation.

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  • (PMID = 18997771.001).
  • [ISSN] 1476-4687
  • [Journal-full-title] Nature
  • [ISO-abbreviation] Nature
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA095262-06; United States / NCI NIH HHS / CA / CA129660-02; United States / NCI NIH HHS / CA / R37-CA50286; United States / NCI NIH HHS / CA / CA050286-20; United States / NCI NIH HHS / CA / CA078045-100004; United States / NCI NIH HHS / CA / R01 CA095262; United States / NCI NIH HHS / CA / R37 CA050286; United States / NCI NIH HHS / CA / R01 CA082515; United States / NIGMS NIH HHS / GM / K12 GM068524; United States / NCI NIH HHS / CA / R37 CA050286-20; United States / NCI NIH HHS / CA / CA050286-19; United States / NCI NIH HHS / CA / R21 CA129660; United States / NHLBI NIH HHS / HL / R01 HL078912-04; United States / NCI NIH HHS / CA / R01 CA095262-06; United States / NHLBI NIH HHS / HL / R01 HL078912; United States / NCI NIH HHS / CA / CA078045-109001; United States / NCI NIH HHS / CA / R37 CA050286-19; United States / NCI NIH HHS / CA / P01 CA078045-050004; United States / NCI NIH HHS / CA / R37-CA082515; United States / NCI NIH HHS / CA / CA078045-050004; United States / NHLBI NIH HHS / HL / HL078912-04; United States / NCI NIH HHS / CA / R21 CA129660-02; United States / NCI NIH HHS / CA / P01 CA078045; United States / NCI NIH HHS / CA / P01 CA078045-109001; United States / NCI NIH HHS / CA / R01 CA118165; United States / NCI NIH HHS / CA / P01 CA078045-100004; United States / NIGMS NIH HHS / GM / GM 68524
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Platelet-Derived Growth Factor; 0 / Vascular Endothelial Growth Factor A; 0 / vascular endothelial growth factor A, mouse; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor beta; EC 2.7.10.1 / Receptors, Vascular Endothelial Growth Factor
  • [Other-IDs] NLM/ NIHMS69452; NLM/ PMC2605188
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20. Cadoni G, Agostino S, Volante M, Scipione MS: Sudden cochlear hearing loss as presenting symptom of arachnoid cyst of the posterior fossa. Acta Otorhinolaryngol Ital; 2006 Apr;26(2):115-7
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  • Arachnoid cysts account for almost 1% of neoformations located in the cerebellopontine angle.
  • Arachnoid cysts of the cranial posterior fossa may produce symptoms typical of a tumour such as headache, dizziness, tinnitus and progressive sensorineural hearing loss.

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  • (PMID = 16886854.001).
  • [ISSN] 0392-100X
  • [Journal-full-title] Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale
  • [ISO-abbreviation] Acta Otorhinolaryngol Ital
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2639985
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21. Wilson M, Davies NP, Brundler MA, McConville C, Grundy RG, Peet AC: High resolution magic angle spinning 1H NMR of childhood brain and nervous system tumours. Mol Cancer; 2009 Feb 10;8:6
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  • [Title] High resolution magic angle spinning 1H NMR of childhood brain and nervous system tumours.
  • 1H magic angle spinning NMR spectroscopy (1H HR-MAS) is a powerful tool for determining metabolite profiles from small pieces of intact tissue and could potentially provide important molecular information.
  • Tumour spectra were fitted to a library of individual metabolite spectra to provide metabolite values.

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  • (PMID = 19208232.001).
  • [ISSN] 1476-4598
  • [Journal-full-title] Molecular cancer
  • [ISO-abbreviation] Mol. Cancer
  • [Language] eng
  • [Grant] United Kingdom / Cancer Research UK / / 10342; United Kingdom / Medical Research Council / / G0601327
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2651110
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22. Koch HJ, Roeber S, Zimmermann UW, Schäfer C, Villarrubia V, Kuchelmeister K, Schachenmayr W, Bogdahn U, Steinbrecher A: [Spinal and cerebral leptomeningeal seeding from a melanocytoma of the cerebello-pontine angle]. Wien Med Wochenschr; 2005 Aug;155(15-16):360-4
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  • [Title] [Spinal and cerebral leptomeningeal seeding from a melanocytoma of the cerebello-pontine angle].
  • Meningeal melanocytoma refers to the uncommon clinical appearance of a generally benign tumour deriving from leptomeningeal melanocytes.
  • Meningeal spread of this tumour is very rarely observed.
  • We present the case of a 38-year-old man with meningeal melanocytoma of the cerebello-pontine angle, who showed a biphasic course of this disease, with a stable period followed by a steady progress within few months.
  • This tumor did not respond to a combined radiochemotherapy including oral temozolomide, and the patient died 5 months after starting treatment for this relapse.
  • [MeSH-major] Cerebellopontine Angle. Melanocytes / pathology. Melanoma. Meningeal Neoplasms. Meninges. Neoplasm Seeding

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  • (PMID = 16160923.001).
  • [ISSN] 0043-5341
  • [Journal-full-title] Wiener medizinische Wochenschrift (1946)
  • [ISO-abbreviation] Wien Med Wochenschr
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Austria
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 7GR28W0FJI / Dacarbazine; 85622-93-1 / temozolomide
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23. Hacker AG, Molloy S, Bernard J: The contralateral lamina: a reliable guide in subaxial, cervical pedicle screw placement. Eur Spine J; 2008 Nov;17(11):1457-61
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  • We have assessed the clinical observation that the angle of the contralateral lamina matches the angle required from the sagital plane for the placement of pedicle screws in the subaxial cervical spine.
  • Subjects were excluded if the scan showed signs of fracture, tumour or gross abnormality.
  • The following were measured; the angle of the pedicle relative to the sagital plane, the smallest internal and external diameter of the pedicles and the angle of the lamina.
  • Mean pedicle angle was 130 degrees at C3 and 140 degrees at C7.
  • The contralateral laminar angle correlated well at C3, 4, 5 (R (2) = 0.9, C3 P = 0.002, C4 P = 0.06, C5 P = 0.0004) and was within 1 degrees of pedicle angle.
  • The contralateral lamina provides a reliable intraoperative guide to the angle from the sagital plane for subaxial cervical pedicle instrumentation in adults.

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  • (PMID = 18795348.001).
  • [ISSN] 1432-0932
  • [Journal-full-title] European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
  • [ISO-abbreviation] Eur Spine J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Other-IDs] NLM/ PMC2583189
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24. Rohrbach JM, Grüb M, Schlote T: [Neoplastic secondary glaucomas]. Klin Monbl Augenheilkd; 2005 Oct;222(10):788-96
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The leading mechanisms are direct invasion of the chamber angle by tumour cells, rubeosis iridis, and forward displacement of the iris-lens-diaphragm with (lens induced) pupillary block.
  • As intraocular tumours may have pressure-lowering effects too, eyes bearing a tumour may also be hypotonic or normotonic inspite of a "glaucomatous chamber angle morphology".
  • The therapy of the tumour-induced glaucomas is hardly validated and generally follows the treatment of the other secondary glaucomas.
  • However, filtration procedures are contraindicated when a malignant tumour is diagnosed or suspected.
  • Because of the progress of tumour therapy with salvation of eyes which had to be enucleated in former times and prolongation of survival in some tumour entities (like Non Hodgkin's lymphoma and metastases) the significance of tumour-induced glaucomas will probably further increase in the future.

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  • (PMID = 16240271.001).
  • [ISSN] 0023-2165
  • [Journal-full-title] Klinische Monatsblätter für Augenheilkunde
  • [ISO-abbreviation] Klin Monbl Augenheilkd
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 93
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25. Marton E, Basaldella L, Longatti PL: Minimal surgery for a cerebellopontine angle lipoma. J Clin Neurosci; 2009 Jan;16(1):129-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Minimal surgery for a cerebellopontine angle lipoma.
  • A 46-year-old man presented with a left cerebellopontine angle lipoma of unusual size.
  • Surgical treatment with simple debridement of the arachnoid membranes to reduce internal tension in the tumour resulted in stable pain remission and hypoacusia without additional deficit.
  • [MeSH-major] Cerebellar Neoplasms / surgery. Cerebellopontine Angle / pathology. Cerebellopontine Angle / surgery. Lipoma / surgery. Microsurgery / methods

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  • (PMID = 19013814.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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26. Zaouche S, Ionescu E, Dubreuil C, Ferber-Viart C: Pre- and intraoperative predictive factors of facial palsy in vestibular schwannoma surgery. Acta Otolaryngol; 2005 Apr;125(4):363-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Qualitative parameters: gender; side of the tumor; angle between the tumor and the internal auditory canal (VS/IAC angle) < or = or > 30 degrees; MRI aspect (n = 69); surgical approach; ease of the surgical procedure, the use or non-use of laser dissection; and the histological Antoni's type of the tumor.


27. Di Cataldo A, Lanteri R, Trombatore G, Licata A: Mediastinal ganglioneuroma: a rare and often asymptomatic tumour. A case report. Chir Ital; 2005 May-Jun;57(3):403-5
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  • [Title] Mediastinal ganglioneuroma: a rare and often asymptomatic tumour. A case report.
  • Ganglioneuroma is a very rare tumour characterised by a slow evolution and arising from cells originating in the neural crest.
  • This type of tumour occurs most commonly in the posterior mediastinum and is considered malignant in childhood and benign thereafter.
  • The tumour was encapsulated and adhered tightly to the pleura of the costovertebral angle.
  • The totally asymptomatic clinical picture could be explained by the very slow growth of this type of tumour which can displace the surrounding anatomical structures without infiltration.

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  • (PMID = 16231835.001).
  • [ISSN] 0009-4773
  • [Journal-full-title] Chirurgia italiana
  • [ISO-abbreviation] Chir Ital
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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28. Zhou SH, Ruan LX, Gong L, Wang SQ: Primary malignant myoepithelioma of the left maxillary sinus: a case report. J Int Med Res; 2008 Mar-Apr;36(2):362-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Exploratory biopsy of the left maxillary sinus was performed and pathological examination demonstrated that the tumour was positive for calponin and cytokeratin 14, which are indicative of MME.
  • Primary recurrence and metastasis to the left angle of the mandible occurred 9 months after the surgery.

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  • (PMID = 18380949.001).
  • [ISSN] 0300-0605
  • [Journal-full-title] The Journal of international medical research
  • [ISO-abbreviation] J. Int. Med. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Calcium-Binding Proteins; 0 / Keratin-14; 0 / Microfilament Proteins; 0 / calponin
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29. Rundle P, Singh AD, Rennie I: Proton beam therapy for iris melanoma: a review of 15 cases. Eye (Lond); 2007 Jan;21(1):79-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The main outcome measures were (1) local tumour control, (2) complications, and (3) eye retention.
  • One patient presented with a newly acquired vascular nodule of the iris associated with angle seeding and glaucoma.
  • Tumour control at mean follow-up of 34 months was 93% (14 of 15 eyes).

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  • (PMID = 16410818.001).
  • [ISSN] 0950-222X
  • [Journal-full-title] Eye (London, England)
  • [ISO-abbreviation] Eye (Lond)
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Protons
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30. Ulmar B, Cakir B, Huch K, Puhl W, Richter M: Posterior stabilisation of a malignant cervico-thoracic vertebral bone defect. Acta Orthop Belg; 2005 Jun;71(3):349-52
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  • Necrosis of the tumour following radiotherapy or chemotherapy may lead to the development of fistulae between the oesophagus and adjacent tissues and organs.
  • To prevent imminent paraplegia and to alleviate severe pain, we rigidly stabilised the spine at the cervico-thoracic junction using an angle-stable system through a single posterior approach.
  • This case shows that posterior stabilisation and decompression may be a palliative option for patients with imminent paraplegia and severe pain due to advanced tumour infiltration of the cervico-thoracic spine.

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  • (PMID = 16035711.001).
  • [ISSN] 0001-6462
  • [Journal-full-title] Acta orthopaedica Belgica
  • [ISO-abbreviation] Acta Orthop Belg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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31. Round AR, Wilkinson SJ, Hall CJ, Rogers KD, Glatter O, Wess T, Ellis IO: A preliminary study of breast cancer diagnosis using laboratory based small angle x-ray scattering. Phys Med Biol; 2005 Sep 7;50(17):4159-68
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  • [Title] A preliminary study of breast cancer diagnosis using laboratory based small angle x-ray scattering.
  • Breast tissue collected from tumour samples and normal tissue from bi-lateral mastectomy procedures were examined using small angle x-ray scattering.
  • Previous work has indicated that breast tissue disease diagnosis could be performed using small angle x-ray scattering (SAXS) from a synchrotron radiation source.
  • Consistent and reliable differences in x-ray scatter distributions were observed between samples from normal and tumour tissue samples using the laboratory based 'SAXSess' system.

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  • (PMID = 16177537.001).
  • [ISSN] 0031-9155
  • [Journal-full-title] Physics in medicine and biology
  • [ISO-abbreviation] Phys Med Biol
  • [Language] eng
  • [Publication-type] Clinical Trial; Controlled Clinical Trial; Journal Article; Validation Studies
  • [Publication-country] England
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32. Aisenbrey C, Bertani P, Bechinger B: Solid-state NMR investigations of membrane-associated antimicrobial peptides. Methods Mol Biol; 2010;618:209-33
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  • These studies have shaped our view on how these peptides cause the killing of bacteria, fungi, or tumour cells and how they permeabilize model membranes.
  • Static and magic angle spinning experiments are described.

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  • (PMID = 20094867.001).
  • [ISSN] 1940-6029
  • [Journal-full-title] Methods in molecular biology (Clifton, N.J.)
  • [ISO-abbreviation] Methods Mol. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antimicrobial Cationic Peptides; 0 / Lipid Bilayers
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33. Goorden MC, Beekman FJ: High-resolution tomography of positron emitters with clustered pinhole SPECT. Phys Med Biol; 2010 Mar 7;55(5):1265-77
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  • To deal with this edge penetration, we introduce here clustered multi-pinhole SPECT (CMP): each pinhole in a cluster has a narrow opening angle to reduce photon penetration.
  • Using a digital tumour phantom, we show that CMP resolves many details not assessable with standard USPECT-II and TMP collimators.

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  • (PMID = 20134086.001).
  • [ISSN] 1361-6560
  • [Journal-full-title] Physics in medicine and biology
  • [ISO-abbreviation] Phys Med Biol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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34. Sakai H, Minemura T, Ito N, Miyazawa H, Kurashina K: Isolated osteochondroma near the mandibular angle. Int J Oral Maxillofac Surg; 2007 Mar;36(3):274-5
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  • [Title] Isolated osteochondroma near the mandibular angle.
  • A benign tumour of osseous and cartilaginous origins, osteochondroma generally develops in osseous tissue and is frequently found near the end of long bones.
  • This is a report on a rare case of osteochondroma in soft tissue near the mandibular angle without pedicle to the bone.

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  • (PMID = 17052896.001).
  • [ISSN] 0901-5027
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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35. Boghaert ER, Khandke KM, Sridharan L, Dougher M, DiJoseph JF, Kunz A, Hamann PR, Moran J, Chaudhary I, Damle NK: Determination of pharmacokinetic values of calicheamicin-antibody conjugates in mice by plasmon resonance analysis of small (5 microl) blood samples. Cancer Chemother Pharmacol; 2008 May;61(6):1027-35
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  • This detection system measures changes in the plasma resonance angle caused by the interaction of macromolecules on biosensor chips.
  • This was done by determination of changes in plasma resonance angle after binding of an anti-CM antibody.
  • The presence of a CD22-expressing tumour in mice reduced the plasma levels of the CD22-targeting conjugate but not of the CD33-targeting one.
  • Comparison between the PK-values of CM-conjugates in tumour-bearing and tumour-free mice suggested that retention of the conjugate in tumour tissue due to antigen targeting could be deduced from the plasma levels.
  • [MeSH-minor] Animals. Antibodies, Monoclonal, Humanized. Area Under Curve. Cell Line, Tumor. Half-Life. Humans. Injections, Intraperitoneal. Injections, Intravenous. Mice. Mice, Inbred BALB C. Mice, Nude. Rabbits. Surface Plasmon Resonance

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  • (PMID = 17668210.001).
  • [ISSN] 0344-5704
  • [Journal-full-title] Cancer chemotherapy and pharmacology
  • [ISO-abbreviation] Cancer Chemother. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Aminoglycosides; 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Inotuzumab Ozogamicin; 0 / gemtuzumab
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36. Kaufman MH: Further observations on the removal of an enormous facial tumour by Robert Liston in 1834. Scott Med J; 2006 Nov;51(4):38-41
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  • [Title] Further observations on the removal of an enormous facial tumour by Robert Liston in 1834.
  • Her tumour was believed to have originated as a result of trauma to the left maxillary antrum.
  • The tumour was associated with drooping and disfigurement of the left angle of her mouth and extended forwards from her left external ear to the left side of her nose.
  • The volume of the tumour was just slightly less than that of her face.
  • Since then, additional casts showing her post-operative appearance and that of her tumour have been located, and these form the basis for this follow-up account.

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  • (PMID = 17137148.001).
  • [ISSN] 0036-9330
  • [Journal-full-title] Scottish medical journal
  • [ISO-abbreviation] Scott Med J
  • [Language] eng
  • [Publication-type] Biography; Historical Article; Journal Article
  • [Publication-country] Scotland
  • [Personal-name-as-subject] Liston R
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37. Driemel O, Rieder J, Morsczeck C, Schwarz S, Hakim SG, Müller-Richter U, Reichert TE, Kosmehl H: [Comparison of clinical immunohistochemical findings in keratocystic odontogenic tumours and ameloblastomas considering their risk of recurrence]. Mund Kiefer Gesichtschir; 2007 Sep;11(4):221-31
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  • BACKGROUND: With the new term "keratocystic odontogenic tumour" (KCOT) keratocyts are even in the nomenclature a close differential diagnosis to ameloblastomas (A).
  • Region of origin mandible with predilection of the angle and the ramus: KCOT: 76; A: 12.
  • [MeSH-major] Ameloblastoma / pathology. Biomarkers, Tumor / analysis. Jaw Neoplasms / pathology. Neoplasm Recurrence, Local / pathology. Odontogenic Tumors / pathology

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  • [Cites] Int J Oral Maxillofac Surg. 2006 Aug;35(8):681-90 [16782308.001]
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  • (PMID = 17641919.001).
  • [ISSN] 1432-9417
  • [Journal-full-title] Mund-, Kiefer- und Gesichtschirurgie : MKG
  • [ISO-abbreviation] Mund Kiefer Gesichtschir
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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38. Teo BT, Lin CC, Chiou TL, Chen SC, Yen PS: Unusual magnetic resonance characteristics of a cerebellopontine angle epidermoid cyst with upper cervical spinal canal extension. J Clin Neurosci; 2006 Aug;13(7):781-4
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  • [Title] Unusual magnetic resonance characteristics of a cerebellopontine angle epidermoid cyst with upper cervical spinal canal extension.
  • We present a 27-year-old woman with an epidermoid cyst at the cerebellopontine (CP) angle with caudal extension into the upper cervical spinal canal.
  • We used microneurosurgical techniques for tumour dissection and excision.
  • To our knowledge, this is the fifth example in Index Medicus/MEDLINE of histopathologically proven CP angle epidermoid with cervical spine extension.
  • [MeSH-major] Cerebellar Diseases / pathology. Cerebellopontine Angle / pathology. Epidermal Cyst / pathology. Magnetic Resonance Imaging

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  • (PMID = 16723231.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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39. Hanna SJ, Derham C, Van Hille P, Fenwick JD: Cerebellopontine angle meningioma resulting in middle-ear polyp. J Laryngol Otol; 2006 Sep;120(9):786-8
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  • [Title] Cerebellopontine angle meningioma resulting in middle-ear polyp.
  • We present the case of a 43-year-old woman with a known cerebellopontine angle meningioma who subsequently presented with left-sided otalgia and a middle-ear mass extruding through the tympanic membrane due to local invasion of the meningioma.
  • The tumour was excised surgically.
  • [MeSH-major] Cerebellar Neoplasms / radiography. Cerebellopontine Angle. Ear, Middle / radiography. Meningioma / radiography. Tomography, X-Ray Computed


40. Mossböck G, Weger M, Moray M, Renner W, Haller-Schober EM, Mattes D, Schmut O, Wegscheider B, El-Shabrawi Y: TNF-alpha promoter polymorphisms and primary open-angle glaucoma. Eye (Lond); 2006 Sep;20(9):1040-3
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  • [Title] TNF-alpha promoter polymorphisms and primary open-angle glaucoma.
  • PURPOSE: Primary open-angle glaucoma (POAG) is a multifactorial optic neuropathy with a strong hereditary component.
  • Recent studies suggested a role for tumour necrosis factor-alpha(TNF-alpha) in the pathogenesis of POAG.
  • [MeSH-major] Glaucoma, Open-Angle / genetics. Polymorphism, Genetic. Promoter Regions, Genetic / genetics. Tumor Necrosis Factor-alpha / genetics

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  • (PMID = 16138112.001).
  • [ISSN] 0950-222X
  • [Journal-full-title] Eye (London, England)
  • [ISO-abbreviation] Eye (Lond)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Tumor Necrosis Factor-alpha
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41. Rousselot C, Francois P, Jan M, Bergemer AM: [Report of seven cases of clear-cell meningioma and a literature review]. Ann Pathol; 2010 Apr;30(2):73-82
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  • [Transliterated title] Etude de sept cas de méningiomes à cellules claires et revue de la littérature.
  • CCM occurred in various locations: medullary region (two), sphenoid wing (two), ponto-cerebellar angle (two), tentorium (one).
  • The tumour could be fully resected in three cases.
  • [MeSH-major] Biomarkers, Tumor / analysis. Meningeal Neoplasms / pathology. Meningioma / pathology. Neoplasm Proteins / analysis

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  • [Copyright] Copyright 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20451062.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / Mucin-1; 0 / Neoplasm Proteins; 0 / Receptors, Progesterone; 0 / S100 Proteins; 68238-35-7 / Keratins
  • [Number-of-references] 33
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42. Diaz Anadon A, Lassaletta L, Roda JM, Gavilán Bouzas J: [CSF fistulae following surgery for cerebellopontine angle tumours and their relationship with the body mass index]. Acta Otorrinolaringol Esp; 2009 Sep-Oct;60(5):318-24
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  • [Title] [CSF fistulae following surgery for cerebellopontine angle tumours and their relationship with the body mass index].
  • [Transliterated title] Fístulas de LCR tras la cirugía de tumores del ángulo pontocerebeloso y su relación con el índice de masa corporal.
  • MATERIAL AND METHODS: Retrospective study of 170 patients who had vestibular schwannoma (163) or other tumours in the cerebello pontine angle (CPA) (7).
  • There was not a significant relationship between the apparition of CSF and tumour size, type of approach, age or body mass index (BMI).

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  • (PMID = 19814983.001).
  • [ISSN] 0001-6519
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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43. Heindl LM, Naumann GO, Kruse FE, Holbach LM: Aggressive metastasising adenocarcinoma of the retinal pigment epithelium with trisomy 21. Br J Ophthalmol; 2008 Mar;92(3):389-91
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  • The tumour seeded into the lumbar spinal-cord space.
  • Metastatic foci--not in continuity with the primary process--developed in the parietal lobe and cerebellopontine angle.

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  • [CommentIn] Br J Ophthalmol. 2009 Feb;93(2):276 [19174409.001]
  • (PMID = 18303161.001).
  • [ISSN] 1468-2079
  • [Journal-full-title] The British journal of ophthalmology
  • [ISO-abbreviation] Br J Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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44. Zhang WC, Cheng JP, Li Q, Zhang L, Wang XD, Anniko M: Clinical and pathological analysis of malignant carotid body tumour: a report of nine cases. Acta Otolaryngol; 2009 Nov;129(11):1320-5
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  • [Title] Clinical and pathological analysis of malignant carotid body tumour: a report of nine cases.
  • CONCLUSIONS: Malignant carotid body tumour (MCBT) is a clinically rare disease that often invades the carotid artery and cranial nerves.
  • Diagnosis of malignant tumour should be based on extensive invasion of neighbouring organs and distant metastasis.
  • Eight patients suffered from a cranial nerve dysfunction (defect) and two suffered postoperatively from a hoarse voice, four had a glossal deviation, five had Horner's syndrome and one had a deviation of the lip angle.
  • [MeSH-major] Carotid Body Tumor / surgery

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  • (PMID = 19863331.001).
  • [ISSN] 1651-2251
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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45. Duarte IF, Rocha CM, Barros AS, Gil AM, Goodfellow BJ, Carreira IM, Bernardo J, Gomes A, Sousa V, Carvalho L: Can nuclear magnetic resonance (NMR) spectroscopy reveal different metabolic signatures for lung tumours? Virchows Arch; 2010 Dec;457(6):715-25
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • This study aims to evaluate the potential of (1)H NMR spectroscopy, combined with multivariate statistics, for discriminating between tumour and non-involved (control) pulmonary parenchyma and for providing biochemical information on different histological types.
  • Paired tissue samples from 24 primary lung tumours were directly analysed by high-resolution magic angle spinning (HRMAS) (1)H NMR spectroscopy (500 MHz), and their spectral profiles subjected to principal component analysis (PCA) and partial least squares regression discriminant analysis (PLS-DA).
  • Tumour and adjacent control parenchyma were clearly discriminated in the PLS-DA model with a high level of sensitivity (95% of tumour samples correctly classified) and 100% specificity (no false positives).
  • Furthermore, PLS-DA of a sub-set of tumour samples allowed adenocarcinomas to be discriminated from carcinoid tumours and epidermoid carcinomas, highlighting differences in metabolite levels between these histological types, and therefore revealing valuable knowledge on the biochemistry of different types of bronchial-pulmonary carcinomas.
  • [MeSH-major] Adenocarcinoma / metabolism. Carcinoid Tumor / metabolism. Carcinoma, Squamous Cell / metabolism. Lung Neoplasms / metabolism. Magnetic Resonance Spectroscopy

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  • (PMID = 20941505.001).
  • [ISSN] 1432-2307
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Lactates; IY9XDZ35W2 / Glucose
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46. Jain A, Ablett M, Wardrop P: Vanishing tumour of the internal auditory meatus. J Laryngol Otol; 2009 May;123(5):563-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Vanishing tumour of the internal auditory meatus.
  • The patient was treated with hormone injections.Tumours of the internal auditory meatus and cerebellopontine angle are mostly primary.
  • We discuss the common presenting features, investigations and treatment options for metastatic prostatic tumours of the internal auditory meatus and cerebellopontine angle.

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  • (PMID = 18694536.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Hormonal
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47. Mutlu M, Sagit M, Akin I, Keyik B: An unusual tumour of the cerebellopontine angle. B-ENT; 2009;5(4):269-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An unusual tumour of the cerebellopontine angle.
  • An unusual tumour of the cerebellopontine angle.
  • OBJECTIVE: To report an extremely rare case of lipoma of the cerebellopontine angle (CPA).
  • [MeSH-major] Cerebellar Neoplasms / diagnosis. Cerebellopontine Angle. Lipoma / diagnosis

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  • (PMID = 20163055.001).
  • [ISSN] 1781-782X
  • [Journal-full-title] B-ENT
  • [ISO-abbreviation] B-ENT
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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48. Verma S, Anthony R, Tsai V, Taplin M, Rutka J: Evaluation of cost effectiveness for conservative and active management strategies for acoustic neuroma. Clin Otolaryngol; 2009 Oct;34(5):438-46
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Entry criteria were small tumour size (less than 15 mm in the cerebellopontine angle), patient preference and/or significant co-morbidity.
  • CONCLUSION: An economic advantage can be demonstrated for the conservative management of acoustic neuromas compared to microsurgical removal and gamma knife radiotherapy on the proviso that no increase in active treatment complications arose from continued tumour growth during the period of observation.

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  • [CommentIn] Clin Otolaryngol. 2010 Feb;35(1):69-70; author reply 70-1 [20447172.001]
  • (PMID = 19793276.001).
  • [ISSN] 1749-4486
  • [Journal-full-title] Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery
  • [ISO-abbreviation] Clin Otolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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49. Nakamura M, Roser F, Dormiani M, Vorkapic P, Samii M: Surgical treatment of cerebellopontine angle meningiomas in elderly patients. Acta Neurochir (Wien); 2005 Jun;147(6):603-9; discussion 609-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical treatment of cerebellopontine angle meningiomas in elderly patients.
  • BACKGROUND: The aim of this study is to assess the morbidity and mortality of meningioma surgery in patients over 70 years of age harbouring a tumour at the cerebellopontine angle as one representative location of the posterior fossa in comparison with a matched group of young patients.
  • METHOD: A retrospective analysis based on clinical charts, surgical records, histological records, imaging studies and follow up records was conducted to select patients over 70 years who underwent surgery for cerebellopontine angle meningiomas.
  • FINDINGS: There were 421 meningiomas located in the cerebellopontine angle, 21 patients were older than 70 years (range 70-84).
  • There were 56 younger patients (mean age 52.4 years; range 24.5-69.75 years) with corresponding tumour size and location.
  • [MeSH-major] Cerebellar Neoplasms / surgery. Cerebellopontine Angle / surgery. Meningioma / surgery. Microsurgery / adverse effects. Neurosurgical Procedures / adverse effects

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  • (PMID = 15812593.001).
  • [ISSN] 0001-6268
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Austria
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50. Peet AC, McConville C, Wilson M, Levine BA, Reed M, Dyer SA, Edwards EC, Strachan MC, McMullan DJ, Wilkes TM, Grundy RG: 1H MRS identifies specific metabolite profiles associated with MYCN-amplified and non-amplified tumour subtypes of neuroblastoma cell lines. NMR Biomed; 2007 Nov;20(7):692-700
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] 1H MRS identifies specific metabolite profiles associated with MYCN-amplified and non-amplified tumour subtypes of neuroblastoma cell lines.
  • Numerous studies have sought to identify the associated genetic abnormalities in the tumour, resulting in the identification of useful prognostic markers.
  • In vitro magic angle spinning (1)H MRS was performed on cell suspensions, and the spectra analysed to obtain metabolite concentration ratios relative to total choline (tCho).
  • [MeSH-minor] Cell Line, Tumor. Choline / metabolism. Humans. N-Myc Proto-Oncogene Protein. Principal Component Analysis

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  • [Copyright] Copyright (c) 2007 John Wiley & Sons, Ltd.
  • (PMID = 17506115.001).
  • [ISSN] 0952-3480
  • [Journal-full-title] NMR in biomedicine
  • [ISO-abbreviation] NMR Biomed
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / G0601327
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / MYCN protein, human; 0 / N-Myc Proto-Oncogene Protein; 0 / Nuclear Proteins; 0 / Oncogene Proteins; N91BDP6H0X / Choline
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51. Brewis S, Baguley DM: Management of tinnitus induced by brainstem and cerebellar infarction associated with complications of cerebello-pontine angle surgery. J Laryngol Otol; 2007 Apr;121(4):393-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Management of tinnitus induced by brainstem and cerebellar infarction associated with complications of cerebello-pontine angle surgery.
  • Following surgery in the USA in 1992 to remove a large right cerebello-pontine angle tumour, a 39-year-old woman developed severe brainstem and cerebellar infarction.
  • [MeSH-major] Brain Stem Infarctions / complications. Cerebellar Neoplasms / complications. Cerebellopontine Angle. Cerebral Infarction / complications. Meningioma / complications. Tinnitus / etiology

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  • (PMID = 17403265.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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52. Gerganov VM, Giordano M, Herold C, Samii A, Samii M: An electrophysiological study on the safety of the endoscope-assisted microsurgical removal of vestibular schwannomas. Eur J Surg Oncol; 2010 Apr;36(4):422-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The structural and functional preservation of facial and cochlear nerves, radicality of tumour removal, and CSF leak rate were evaluated and compared to historical group of 50 patients (Group B), operated consecutively with classical microsurgical technique.
  • Endoscopic inspection provided early and detailed view of anatomical relations within cerebellopontine angle and internal auditory canal and confirmed completeness of tumour removal.
  • Total tumour removal was achieved in all patients from Group A and in 49/50 from Group B.

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  • [Copyright] Copyright (c) 2009 Elsevier Ltd. All rights reserved.
  • (PMID = 19942394.001).
  • [ISSN] 1532-2157
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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53. Falzon G, Pearson S, Murison R, Hall C, Siu K, Round A, Schültke E, Kaye AH, Lewis R: Myelin structure is a key difference in the x-ray scattering signature between meningioma, schwannoma and glioblastoma multiforme. Phys Med Biol; 2007 Nov 7;52(21):6543-53
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Small angle x-ray scattering (SAXS) patterns of benign and malignant brain tumour tissue were examined.


54. Tran TA, Hirst LW, Axelsen RA, Welch R: Iris melanoma in 12-year-old boy. Clin Exp Ophthalmol; 2006 Jul;34(5):489-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • There were smaller scattered nodules scattered within the iris and anterior chamber.
  • Ultrasound biomicroscopy examination revealed no tumour behind the iris.
  • Histopathologic examination confirmed malignant melanoma confined to the iridocorneal angle, iris, ciliary body and inner layer of the anterior sclera.

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  • (PMID = 16872348.001).
  • [ISSN] 1442-6404
  • [Journal-full-title] Clinical & experimental ophthalmology
  • [ISO-abbreviation] Clin. Experiment. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
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55. Klieb HB, Freeman BV: Trigeminal neuralgia caused by intracranial epidermoid tumour: report of a case. J Can Dent Assoc; 2008 Feb;74(1):63-5
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  • [Title] Trigeminal neuralgia caused by intracranial epidermoid tumour: report of a case.
  • This case report describes an epidermoid tumour at the cerebellopontine angle in a middle-aged man with otherwise classical unilateral trigeminal neuralgia.
  • The case highlights the difficulties of diagnosis and the importance of a multidisciplinary approach when trigeminal neuralgia occurs concurrently with a brain tumour.
  • [MeSH-minor] Adult. Cerebellopontine Angle. Humans. Magnetic Resonance Imaging. Male

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  • (PMID = 18298887.001).
  • [ISSN] 1488-2159
  • [Journal-full-title] Journal (Canadian Dental Association)
  • [ISO-abbreviation] J Can Dent Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
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56. Oishi M, Fukuda M, Saito A, Hiraishi T, Fuji Y: [Presurgical evaluaton for lateral suboccipital craniotomy using contrast-enhanced CT volumetric imaging]. No Shinkei Geka; 2009 May;37(5):459-65
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The morphologic analysis for our 48 cases with cerebello-pontine angle tumor or neurovascular compression syndrome showed running patterns of OA, varieties of MEV and PCEV in their sizes and connections, right dominance of TSS, and the various relationship between the TSS and the asterion.

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  • (PMID = 19432094.001).
  • [ISSN] 0301-2603
  • [Journal-full-title] No shinkei geka. Neurological surgery
  • [ISO-abbreviation] No Shinkei Geka
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Contrast Media
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57. Kovaĺ J, Krempaská S: Anatomic logic of the foramen Luschka in neurootologic surgery. Otolaryngol Pol; 2009 Sep-Oct;63(5):398-402
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  • Blockage of the foramen of Luschka with a medium or big tumour may impaire the CSF circulation.
  • In all other situations where there is no blockage of the CSF circulation in the affected pontocerebellar angle the choice of a surgical approach is determined by the state of hearing and character of disease.
  • [MeSH-minor] Cerebellopontine Angle. Humans. Neuronavigation / methods

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  • (PMID = 20169903.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] eng
  • [Publication-type] Editorial
  • [Publication-country] Poland
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58. Nannapaneni R, Satheesan K, Nath FP: Lintene granuloma following microvascular decompression mimicking a cerebellopontine angle tumour. J Clin Neurosci; 2006 Apr;13(3):380-3
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  • [Title] Lintene granuloma following microvascular decompression mimicking a cerebellopontine angle tumour.
  • At presentation, the clinical and radiological findings were suggestive of a tumor.

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  • (PMID = 16540325.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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59. Seker A, Toktas ZO, Peker S, Batirel HA, Necmettin Pamir M: Asystole due to trigemino-cardiac reflex: a rare complication of trans-sphenoidal surgery for pituitary adenoma. J Clin Neurosci; 2009 Feb;16(2):338-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • This reflex occurs during craniofacial surgery and other operations on or near the cerebellopontine angle, petrosal sinus, orbit and trigeminal ganglion.
  • Intra-operative MRI showed a small tumour remnant in the right cavernous sinus.
  • The operation was terminated but subsequent radiosurgery was planned for the residual tumor.

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  • [CommentIn] J Clin Neurosci. 2009 Dec;16(12):1709 [19766494.001]
  • [CommentIn] J Clin Neurosci. 2009 Nov;16(11):1508 [19632118.001]
  • (PMID = 19056276.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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60. Hong XY, Chou YC, Lazareff JA: Brain stem candidiasis mimicking cerebellopontine angle tumor. Surg Neurol; 2008 Jul;70(1):87-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Brain stem candidiasis mimicking cerebellopontine angle tumor.
  • The MRI of the patient showed an enhancing partially cystic and partially solid mass in the right CP angle cistern, interpreting as CP tumor.
  • CONCLUSIONS: Brainstem candidiasis in immunocompetent host can masquerade the CP angle tumor.
  • [MeSH-major] Candidiasis / diagnosis. Central Nervous System Fungal Infections / diagnosis. Cerebellar Neoplasms / diagnosis. Cerebellopontine Angle

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  • (PMID = 18313733.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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61. Davies NP, Wilson M, Harris LM, Natarajan K, Lateef S, Macpherson L, Sgouros S, Grundy RG, Arvanitis TN, Peet AC: Identification and characterisation of childhood cerebellar tumours by in vivo proton MRS. NMR Biomed; 2008 Oct;21(8):908-18
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Spectra were analysed using LCModel to yield metabolite profiles, and key metabolite assignments were verified by comparison with high-resolution magic-angle-spinning NMR of representative tumour biopsy samples.
  • [MeSH-major] Biomarkers, Tumor / analysis. Cerebellar Neoplasms / diagnosis. Cerebellar Neoplasms / metabolism. Magnetic Resonance Spectroscopy / methods. Protons

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  • [Copyright] Copyright (c) 2008 John Wiley & Sons, Ltd.
  • (PMID = 18613254.001).
  • [ISSN] 0952-3480
  • [Journal-full-title] NMR in biomedicine
  • [ISO-abbreviation] NMR Biomed
  • [Language] eng
  • [Grant] United Kingdom / Cancer Research UK / / 10342; United Kingdom / Medical Research Council / / G0601327; United Kingdom / Department of Health / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Protons
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62. Meng L, Yuguang L, Feng L, Wandong S, Shugan Z, Chengyuan W: Cerebellopontine angle epidermoids presenting with trigeminal neuralgia. J Clin Neurosci; 2005 Sep;12(7):784-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cerebellopontine angle epidermoids presenting with trigeminal neuralgia.
  • We studied the clinical characteristics of cerebellopontine angle (CPA) epidermoids presenting with trigeminal neuralgia (TN).
  • In addition to complete resection of the tumour, arterial compression at the root entry zone (REZ) of the trigeminal nerve should be sought, and if found, a microvascular decompression (MVD) should be performed.
  • [MeSH-major] Cerebellar Diseases / complications. Cerebellopontine Angle / pathology. Trigeminal Neuralgia / complications

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  • (PMID = 16150598.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article
  • [Publication-country] Scotland
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63. Dragne C, Filip M, Magureanu M, Nicodin A: [Anterior uveal malignant melanoma with subconjunctival extension--a clinical case]. Oftalmologia; 2005;49(1):22-5
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  • [Title] [Anterior uveal malignant melanoma with subconjunctival extension--a clinical case].
  • [Transliterated title] Melanom malign de tract uveal anterior diseminat, posibil iatrogen--caz clinic.
  • The authors present the case of a patient with intraocular tumour and secondary glaucoma, which has been surgically treated for acute angle-closure glaucoma in a local hospital.
  • [MeSH-major] Ciliary Body. Conjunctival Neoplasms. Glaucoma, Angle-Closure. Melanoma. Uveal Neoplasms

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  • (PMID = 15934332.001).
  • [ISSN] 1220-0875
  • [Journal-full-title] Oftalmologia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Oftalmologia
  • [Language] rum
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Romania
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64. Dizdarević K, Link MJ: [Operative treatment of the vestibular schwannoma (acoustic neuroma): correlation between the microsurgical approach and cranial nerve lesion]. Med Arh; 2005;59(3):160-3
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  • INTRODUCTION: Vestibular schwannoma (VS) is a benign tumour of cerebellopontine angle which total microsurgical resection is considered as a complex surgery.


65. Hajioff D, Raut VV, Walsh RM, Bath AP, Bance ML, Guha A, Tator CH, Rutka JA: Conservative management of vestibular schwannomas: third review of a 10-year prospective study. Clin Otolaryngol; 2008 Jun;33(3):255-9
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  • No factors predictive of tumour growth or failure of conservative management could be identified.
  • Cerebellopontine angle tumours grew faster (1.4 mm/year) than intracanalicular tumours (0 mm/year, P < 0.01); 92% had growth rates under 2 mm/year.

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  • [CommentIn] Clin Otolaryngol. 2008 Jun;33(3):236-8 [18559029.001]
  • (PMID = 18559034.001).
  • [ISSN] 1749-4486
  • [Journal-full-title] Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery
  • [ISO-abbreviation] Clin Otolaryngol
  • [Language] eng
  • [Publication-type] Letter; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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66. Both M, Schultze J, Reuter M, Bewig B, Hubner R, Bobis I, Noth R, Heller M, Biederer J: Fast T1- and T2-weighted pulmonary MR-imaging in patients with bronchial carcinoma. Eur J Radiol; 2005 Mar;53(3):478-88
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  • MATERIAL AND METHODS: Three fast chest MRI sequences from 20 patients with central or peripheral bronchial carcinoma were evaluated by two observers for relation of tumour to adjacent structures, lymph node enlargement, additional pulmonary lesions and artefacts.
  • MRI comprised a T1-3D-GRE breath-hold examination ("VIBE", TR/TE 4.5/1.9 ms, flip-angle 12 degrees , matrix 502 x 512, 2.5 mm coronal slices), a breath-hold, T2-HASTE sequence (TR/TE 2000/43 ms, matrix 192 x 256, 10 mm coronal slices) and a respiration-triggered T2-TSE sequence (TR/TE 3000-6000/120 ms, matrix 270 x 512, 6 mm transverse slices).
  • RESULTS: The presence of the primary bronchial carcinoma and infiltration of thoracic structures by tumour tissue could be demonstrated by all sequences.
  • Concerning the differentiation between tumour and adjacent atelectasis (n = 8), T2-weighted TSE imaging was superior to CT and VIBE in all cases and to HASTE sequence in 4/8 patients.
  • To obtain more detail resolution and to differentiate tumour tissue from adjacent atelectasis, T2-TSE examination may be added in selected cases.

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  • (PMID = 15741023.001).
  • [ISSN] 0720-048X
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Ireland
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67. Gao HC, Lin DH: [Applications of 1H nuclear magnetic resonance spectroscopy and nuclear magnetic resonance-based metabonomics in tumour studies]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao; 2007 Dec;29(6):803-10
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  • [Title] [Applications of 1H nuclear magnetic resonance spectroscopy and nuclear magnetic resonance-based metabonomics in tumour studies].
  • 1H nuclear magnetic resonance (1H NMR) spectroscopy has found widespread applications in tumour studies.
  • Several complementary NMR techniques have provided valuable information concerning tumours, including in vivo localized 1H NMR spectroscopy, ex vivo high-resolution 1H NMR spectroscopy of extracts of intact tissue biopsy samples, high-resolution magic angle spinning 1H NMR spectroscopy of intact tissue biopsy samples, and in vitro high-resolution 1H NMR spectroscopy of body fluids.
  • On the basis of the combination of NMR measurements with multivariate data analysis, 1H NMR-based metabonomics has become a promisingly novel approach in the studies of tumour early diagnosis, processes and prognosis estimate.

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  • (PMID = 18595263.001).
  • [ISSN] 1000-503X
  • [Journal-full-title] Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
  • [ISO-abbreviation] Zhongguo Yi Xue Ke Xue Yuan Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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68. Jaspers GW, Stegenga B: [Trigeminal neuralgia by an acoustic neuroma. The need of imaging]. Ned Tijdschr Tandheelkd; 2005 Jun;112(6):231-3
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  • [Transliterated title] Trigeminusneuralgie door een neurinoom van de nervus acusticus. De noodzaak van beeldvormend onderzoek.
  • This investigation showed an acoustic neuroma in the cerebellopontine angle.
  • Without magnetic resonance imaging this benign tumour would be diagnosed in a much later stage and the patient would have suffered unnecessary co-morbidity.
  • [MeSH-minor] Adult. Cerebellopontine Angle. Female. Humans


69. Cantarella C, Sepe L, Fioretti F, Ferrari MC, Paolella G: Analysis and modelling of motility of cell populations with MotoCell. BMC Bioinformatics; 2009;10 Suppl 12:S12
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  • BACKGROUND: Cell motility plays a central role in development, wound-healing and tumour invasion.
  • Statistical analysis of cell behaviour consists of the evaluation of descriptive parameters such as average speed and angle, directional persistence, path vector length, calculated for the whole population as well as for each cell and for each step of the migration; in this way the behaviour of a whole cell population may be assessed as a whole or as a sum of individual entities.

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  • (PMID = 19828072.001).
  • [ISSN] 1471-2105
  • [Journal-full-title] BMC bioinformatics
  • [ISO-abbreviation] BMC Bioinformatics
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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70. Bayley E, Zia Z, Kerslake R, Klezl Z, Boszczyk BM: Lamina-guided lateral mass screw placement in the sub-axial cervical spine. Eur Spine J; 2010 Apr;19(4):660-4
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  • Several screw trajectories have been described to overcome the risks of neurovascular injury; however, each of these techniques relies on the surgeon's visual estimation of the trajectory angle.
  • Exclusion criteria were severe degeneration, malformations, tumour, vertebral body fractures and an age of less than 18 or greater than 80 years.

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  • (PMID = 19949819.001).
  • [ISSN] 1432-0932
  • [Journal-full-title] European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
  • [ISO-abbreviation] Eur Spine J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Other-IDs] NLM/ PMC2899841
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71. Payne GS, Troy H, Vaidya SJ, Griffiths JR, Leach MO, Chung YL: Evaluation of 31P high-resolution magic angle spinning of intact tissue samples. NMR Biomed; 2006 Aug;19(5):593-8
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  • [Title] Evaluation of 31P high-resolution magic angle spinning of intact tissue samples.
  • The first detailed evaluation is presented of high-resolution (31)P MRS using magic angle spinning (MAS) of intact tissue samples and comparison with the conventional method of studying tissue extracts.
  • In tumour samples there was no significant change in peak areas over a 2-h period, while peaks sensitive to pH (inorganic phosphate, PE and PC) showed a small change in chemical shift, corresponding to a change of 0.13 +/- 0.06 pH units.
  • The methodology has particular application in studying phospholipid metabolism in cancer and in monitoring tumour response to treatment, where concentrations of phospholipid-related metabolites are found to alter following response to a wide range of anti-cancer therapies.

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  • (PMID = 16645958.001).
  • [ISSN] 0952-3480
  • [Journal-full-title] NMR in biomedicine
  • [ISO-abbreviation] NMR Biomed
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Phosphates; 0 / Phosphorus Isotopes; 0 / Tissue Extracts
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72. Conceição AL, Antoniassi M, Poletti ME: Analysis of breast cancer by small angle X-ray scattering (SAXS). Analyst; 2009 Jun;134(6):1077-82
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  • [Title] Analysis of breast cancer by small angle X-ray scattering (SAXS).
  • Small angle X-ray scattering (SAXS) images of normal breast tissue and benign and malignant breast tumour tissues, fixed in formalin, were measured at the momentum transfer range of 0.063 nm(-1) < or = q (= 4pisin(theta/2)/lambda) < or = 2.720 nm(-1).
  • [MeSH-major] Breast Neoplasms / pathology. Scattering, Small Angle. X-Ray Diffraction

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  • (PMID = 19475132.001).
  • [ISSN] 1364-5528
  • [Journal-full-title] The Analyst
  • [ISO-abbreviation] Analyst
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 1HG84L3525 / Formaldehyde
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73. Röllinghoff M, Siewe J, Zarghooni K, Sobottke R, Alparslan Y, Eysel P, Delank KS: Effectiveness, security and height restoration on fresh compression fractures--a comparative prospective study of vertebroplasty and kyphoplasty. Minim Invasive Neurosurg; 2009 Oct;52(5-6):233-7
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  • Clinical analysis included Oswestry score and VAS index; the vertebral body height restoration (mean vertebral body height, kyphosis angle, anterior/posterior edge) was evaluated radiologically; furthermore, all occurring complications were recorded.
  • The follow-up time was 1 year, 80 patients could be examined at follow-up; 8 patients had died of a tumour disease, lost to follow-up were 2.2%.

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  • (PMID = 20077364.001).
  • [ISSN] 1439-2291
  • [Journal-full-title] Minimally invasive neurosurgery : MIN
  • [ISO-abbreviation] Minim Invasive Neurosurg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Bone Cements
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74. Changizi V, Oghabian MA, Speller R, Sarkar S, Kheradmand AA: Application of small angle X-ray scattering (SAXS) for differentiation between normal and cancerous breast tissue. Int J Med Sci; 2005;2(3):118-21
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  • [Title] Application of small angle X-ray scattering (SAXS) for differentiation between normal and cancerous breast tissue.
  • INTRODUCTION: Small angle, between 3 degrees and 10 degrees, X ray scattering is predominantly coherent giving rise to diffraction effects that can be observed as constructive and destructive interferences.
  • The optimum scattering angle, determined from a series of measurements on adipose breast tissue at several angles from 4 to 7.3 degrees, was found to be 6.5 degrees.
  • The samples were both normal and tumour samples.
  • Adipose tissue, mixed tissue (adipose & fibroglandular) and tumor have peaks at different values of momentum transfer that can be used to identify the tissue.
  • CONCLUSION: We were able to differentiate between normal, benign and malignant breast tissues by using energy dispersive small angle x-ray scattering.

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  • (PMID = 16007264.001).
  • [ISSN] 1449-1907
  • [Journal-full-title] International journal of medical sciences
  • [ISO-abbreviation] Int J Med Sci
  • [Language] eng
  • [Publication-type] Journal Article
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  • [Other-IDs] NLM/ PMC1168877
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75. Zouari IB, Chtourou I, Ghariani M, Makni S, Khabir A, Gouiaa N, Boudawara Z, Sallemi Boudawara T: [Epithelioid schwannoma of the acoustic nerve: a case report]. Ann Pathol; 2006 Dec;26(6):450-3
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  • We report the sixth case of epithelioid schwannoma of the acoustic nerve diagnosed in a 57 year-old woman operated for neurinoma of the right cerebellopontine angle.
  • Histologically, the tumour was composed of round or polygonal atypic cells associated with spindle cell areas.

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  • (PMID = 17255905.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Ki-67 Antigen
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81. Bonneville F, Savatovsky J, Chiras J: Imaging of cerebellopontine angle lesions: an update. Part 2: intra-axial lesions, skull base lesions that may invade the CPA region, and non-enhancing extra-axial lesions. Eur Radiol; 2007 Nov;17(11):2908-20
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  • [Title] Imaging of cerebellopontine angle lesions: an update. Part 2: intra-axial lesions, skull base lesions that may invade the CPA region, and non-enhancing extra-axial lesions.
  • Computed tomography (CT) and magnetic resonance (MR) imaging reliably demonstrate typical features of vestibular schwannomas or meningiomas in the vast majority of mass lesions responsible for cerebellopontine angle (CPA) syndrome.
  • Tumours can also extend into the CPA by extension from the skull base (paraganglioma, chondromatous tumours, chordoma, cholesterol granuloma, endolymphatic sac tumour).
  • Finally, brain stem or ventricular tumours can present with a significant exophytic component in the CPA that may be difficult to differentiate from an extra-axial lesion (lymphoma, hemangioblastoma, choroid plexus papilloma, ependymoma, glioma, medulloblastoma, dysembryoplastic neuroepithelial tumour).
  • [MeSH-major] Cerebellar Neoplasms / diagnosis. Cerebellopontine Angle. Magnetic Resonance Imaging / methods. Tomography, X-Ray Computed

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  • (PMID = 17569053.001).
  • [ISSN] 0938-7994
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] AU0V1LM3JT / Gadolinium
  • [Number-of-references] 75
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82. Chen B, Hu SY, Wang L, Wang KX, Zhang GY, Zhang HF: Reoperation of biliary tract by laparoscopy: a consecutive series of 26 cases. Acta Chir Belg; 2007 Jun;107(3):292-6
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  • In the 26 patients, preoperatively, stenosis of bile duct and malignant tumour were excluded by both radiological examination and detection of serological tumour markers.
  • One patient was converted to open operation and the common duct stones were removed by right angle forceps through short incision.

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  • (PMID = 17685256.001).
  • [ISSN] 0001-5458
  • [Journal-full-title] Acta chirurgica Belgica
  • [ISO-abbreviation] Acta Chir. Belg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Belgium
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83. Yuguang L, Chengyuan W, Meng L, Shugan Z, Wandong S, Gang L, Xingang L: Neuroendoscopic anatomy and surgery of the cerebellopontine angle. J Clin Neurosci; 2005 Apr;12(3):256-60
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  • [Title] Neuroendoscopic anatomy and surgery of the cerebellopontine angle.
  • To probe the feasibility and utility of neuroendoscopic inspection of the anatomy of the cerebellopontine angle (CPA) and of neuroendoscopic assisted microneurosurgery (NEAMN) for CPA lesions via a retrosigmoid approach, we used retrosigmoid NEAMN in 28 patients with CPA lesions.
  • NEAMN tumour resection was performed in eight acoustic neuromas, one meningioma and 14 cholesteatomas and NEAMN vascular decompression was performed in five patients with trigeminal neuralgia.
  • Complete excision of the tumour with preservation of the facial nerve was achieved in all eight acoustic neuromas.
  • Likewise, total resection of the tumour was possible in the 14 cholesteatomas and one meningioma.
  • [MeSH-major] Cerebellopontine Angle / anatomy & histology. Cerebellopontine Angle / surgery. Neurosurgical Procedures

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  • (PMID = 15851077.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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84. James ML, Husain AM: Brainstem auditory evoked potential monitoring: when is change in wave V significant? Neurology; 2005 Nov 22;65(10):1551-5
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  • BACKGROUND: The probability of hearing loss during cerebellopontine angle (CPA) surgery can be reduced by using brainstem auditory evoked potential (BAEP) intraoperative monitoring (IOM).
  • When patients with CPA tumor were excluded, a significantly higher number of patients in Group 4 had hearing loss.
  • Analysis of the patients with CPA tumor showed no difference in the frequency of hearing loss in any of the groups; even a large number (50%) of Group 1 patients had hearing impairment.
  • For non-cerebellopontine angle tumor surgery, hearing loss occurs usually only with permanent loss of wave V; much smaller changes may be important in cerebellopontine angle tumor surgery.

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  • [CommentIn] Neurology. 2005 Nov 22;65(10):1522-3 [16301476.001]
  • (PMID = 16301480.001).
  • [ISSN] 1526-632X
  • [Journal-full-title] Neurology
  • [ISO-abbreviation] Neurology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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85. Stefanović I, Dacić-Krnjaja B, Djurić S: [Ultrasound biomicroscopy in diagnosis of anterior segment pathology]. Srp Arh Celok Lek; 2009 Mar-Apr;137(3-4):185-8
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  • [Title] [Ultrasound biomicroscopy in diagnosis of anterior segment pathology].
  • INTRODUCTION: Ultrasound biomicroscopy (UBM) is a non-invasive diagnostic procedure, developed in order to achieve better visualization of the anterior segment of the eye.
  • The existence of the ciliary body tumour was suspected, so she underwent a UBM diagnostic procedure.
  • UBM showed fibrin in the anterior chamber of the eye, occlusion of the pupil, and the absence of tumour.
  • The second patient had a part of the chamber angle filled with solid lesion.
  • UBM showed a solid tumour lesion filling the chamber angle in the lower part of the anterior chamber.
  • The origin of the tumour was the ciliary body rather than the choroid which was shown by the B scan ultrasound.
  • Our fourth patient underwent an antiglaucomatous procedure, and the assessment of the chamber angle opening was the reason for the UBM examination.
  • Comparing them to normal values, we came to the conclusion that the chamber angle was open in the lower part of the anterior chamber.
  • CONCLUSION: Ultrasound biomicroscopy gives us plenty of useful information when it comes to diagnosing the anterior chamber pathology.
  • [MeSH-major] Anterior Eye Segment / ultrasonography. Eye Diseases / ultrasonography. Microscopy, Acoustic
  • [MeSH-minor] Ciliary Body. Female. Glaucoma, Angle-Closure / ultrasonography. Humans. Male. Uveal Neoplasms / ultrasonography

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  • (PMID = 19459567.001).
  • [ISSN] 0370-8179
  • [Journal-full-title] Srpski arhiv za celokupno lekarstvo
  • [ISO-abbreviation] Srp Arh Celok Lek
  • [Language] srp
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Serbia
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86. Mariani PB, Kowalski LP, Magrin J: Reconstruction of large defects postmandibulectomy for oral cancer using plates and myocutaneous flaps: a long-term follow-up. Int J Oral Maxillofac Surg; 2006 May;35(5):427-32
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  • In all cases mandibular resection was indicated for treatment of squamous cell carcinoma of the oral cavity: 25 pelviglossomandibulectomies (resulting in large defects from the angle of the mandible), 2 Commando operations (resulting in lateral defects) and 1 anterior sectional mandibulectomy (resulting in an anterior defect).
  • Tumour stages were T1-T2 (4 cases) and T3-T4 (24 cases).

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  • (PMID = 16442779.001).
  • [ISSN] 0901-5027
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Dental Alloys; 12597-68-1 / Stainless Steel; D1JT611TNE / Titanium
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87. Wolf G, Schindler S, Koch A, Abolmaali N: Diffusion-weighted MRI for tumour volume delineation: comparison with morphological MRI. J Med Imaging Radiat Oncol; 2010 Jun;54(3):194-201
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  • [Title] Diffusion-weighted MRI for tumour volume delineation: comparison with morphological MRI.
  • Diffusion-weighted magnetic resonance imaging (dwMRI) is sensitive to tissue microstructure on the cellular level and may therefore help to define biological tumour subvolumes and add complementary information to morphology-based cancer treatment protocols and therapy monitoring.
  • The purpose of this study was therefore to evaluate the potential of dwMRI as compared with morphological MRI (mMRI) for tumour volume delineation using a nude rat human tumour xenograft model.
  • Sixteen tumour-bearing rats (10 H1299, six FaDu) were examined with mMRI (T2-weighted true fast imaging with steady precession (TrueFISP), T1-weighted fast low angle shot (FLASH), T2-weighted dual echo steady state (DESS)) and echo-planar dwMRI in a clinical scanner at 1.5 T.
  • For each method, we compared tumour volume and intra- and inter-observer variability of tumour outer edge delineation (disregarding intra-tumoural structure) as well as tumour signal-to-noise ratio (SNR) and tumour-to-muscle contrast-to-noise ratio (CNR).
  • Median tumour volumes as measured by dwMRI (3.5 cm(3)) and mMRI (TrueFISP: 3.3 cm(3); FLASH: 3.3 cm(3); DESS: 3.2 cm(3)) were not significantly different and significantly correlated.
  • In conclusion, dwMRI allows tumour delineation with overall volume estimation comparable with mMRI approaches but slightly higher observer variability.
  • Thus, besides tumour outline, it may potentially supplement morphology-based therapy planning and monitoring with additional biological information.
  • [MeSH-minor] Animals. Cell Line, Tumor. Humans. Male. Rats. Rats, Nude. Reproducibility of Results. Sensitivity and Specificity

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  • (PMID = 20598006.001).
  • [ISSN] 1754-9485
  • [Journal-full-title] Journal of medical imaging and radiation oncology
  • [ISO-abbreviation] J Med Imaging Radiat Oncol
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
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88. Perrini P, Rasile F, Leggate J: Trigeminal neuralgia as initial symptom of paramedian tentorial meningioma. Neurol Sci; 2009 Feb;30(1):81-3
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  • Posterior cranial fossa tumours, not involving the cerebellopontine angle cistern, are a rare cause of trigeminal neuralgia (TN).
  • Trigeminal pain resolved after gross total tumour resection and postoperative magnetic resonance images disclosed a minimal residual tumour in the torcular region as well as ascent of cerebellar tonsils.

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  • (PMID = 19169626.001).
  • [ISSN] 1590-1874
  • [Journal-full-title] Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
  • [ISO-abbreviation] Neurol. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
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89. Lee H, Khan R, O'Keefe M: Aniridia: current pathology and management. Acta Ophthalmol; 2008 Nov;86(7):708-15
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  • Aniridia is a rare panocular disorder affecting the cornea, anterior chamber, iris, lens, retina, macula and optic nerve.
  • It is associated with a number of syndromes, including Wilm's tumour, bilateral sporadic aniridia, genitourinary abnormalities and mental retardation (WAGR) syndrome.
  • It also results in abnormalities in the differentiation of the angle, resulting in glaucoma.
  • Glaucoma may also develop as a result of progressive angle closure from synechiae.
  • Aniridia is a profibrotic disorder, and as a result many interventions--including penetrating keratoplasty and filtration surgery--fail.

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  • (PMID = 18937825.001).
  • [ISSN] 1755-3768
  • [Journal-full-title] Acta ophthalmologica
  • [ISO-abbreviation] Acta Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Eye Proteins; 0 / Homeodomain Proteins; 0 / PAX6 protein; 0 / Paired Box Transcription Factors; 0 / Repressor Proteins
  • [Number-of-references] 89
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90. Wilson M, Davies NP, Grundy RG, Peet AC: A quantitative comparison of metabolite signals as detected by in vivo MRS with ex vivo 1H HR-MAS for childhood brain tumours. NMR Biomed; 2009 Feb;22(2):213-9
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  • (1)H MRS provides a powerful method for investigating tumour metabolism by allowing the measurement of metabolites in vivo.
  • Recently, the technique of (1)H high-resolution magic angle spinning (HR-MAS) has been shown to produce high-quality data, allowing the accurate measurement of many metabolites present in unprocessed biopsy tissue.
  • The generally good agreement observed between the two techniques suggests that both MRS and HR-MAS can be used to reliably estimate metabolite quantities in brain tumour tissue and that tumour heterogeneity and metabolite degradation do not have an important effect on the HR-MAS metabolite profile for the tumours investigated.
  • [MeSH-major] Biomarkers, Tumor / analysis. Brain / metabolism. Brain / pathology. Brain Neoplasms / diagnosis. Brain Neoplasms / metabolism. Magnetic Resonance Spectroscopy / methods

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  • [Copyright] Copyright (c) 2009 John Wiley & Sons, Ltd.
  • (PMID = 19067434.001).
  • [ISSN] 0952-3480
  • [Journal-full-title] NMR in biomedicine
  • [ISO-abbreviation] NMR Biomed
  • [Language] eng
  • [Grant] United Kingdom / Cancer Research UK / / 10342; United Kingdom / Medical Research Council / / G0601327; United Kingdom / Department of Health / /
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Protons
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91. Capote-Moreno A, Acero J, García-Recuero I, Ruiz J, Serrano R, de Paz V: Giant aneurysmal bone cyst of the mandible with unusual presentation. Med Oral Patol Oral Cir Bucal; 2009 Mar;14(3):E137-40
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  • On the X-ray study, an expansive multilocular and high vascularized bony lesion within the mandibular angle was observed.
  • After selective embolization of the tumour, surgical resection was done with curettage and immediate reconstruction of the defect with an anterior iliac crest graft.

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  • (PMID = 19242394.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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92. Akata S, Kajiwara N, Park J, Yoshimura M, Kakizaki D, Abe K, Hirano T, Ohira T, Tsuboi M, Kato H: Evaluation of chest wall invasion by lung cancer using respiratory dynamic MRI. J Med Imaging Radiat Oncol; 2008 Feb;52(1):36-9
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  • For preoperative evaluation of chest wall invasion by peripheral lung cancer, respiratory dynamic (RD) MRI was carried out in 98 patients in whom conventional CT scan showed that the tumour was abutting the pleural surface, but there was no evidence of definite tumour invasion.
  • RD MR images were acquired by snapshot fast field echo sequence (repetition time = 8, echo time = 3, flip angle = 100) and 25 consecutive images were taken while the patient took deep breaths.
  • These images were evaluated in cine mode to assess tumour movement along the chest wall.
  • Sixty-one patients underwent surgical resection of the tumour and RD MR findings were compared with those in pathological specimens.
  • RD MR showed free tumour movement along the chest wall in 34 patients.

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  • (PMID = 18373824.001).
  • [ISSN] 1754-9477
  • [Journal-full-title] Journal of medical imaging and radiation oncology
  • [ISO-abbreviation] J Med Imaging Radiat Oncol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Australia
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93. Vacher C, Lkah C: The osteomuscular dorsal scapular (OMDS) flap: an alternative technique of mandibular reconstruction. J Plast Reconstr Aesthet Surg; 2010 Feb;63(2):198-204
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  • The pedicle was located 41.2 mm (+/-5.51) lateral to the superior angle and 24.6 mm (+/-7.50) lateral to the medial angle.
  • The main disadvantages of the OMDS flap are the impossibility of placing implants in the bone that have been harvested because of its thickness and the lateral position that has to be changed to supine to allow access for resection of the tumour.

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  • [Copyright] 2008 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 19058774.001).
  • [ISSN] 1878-0539
  • [Journal-full-title] Journal of plastic, reconstructive & aesthetic surgery : JPRAS
  • [ISO-abbreviation] J Plast Reconstr Aesthet Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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94. Gosau M, Vogel C, Moralis A, Proff P, Kleinheinz J, Driemel O: Mandibular prognathism caused by acromegaly - a surgical orthodontic case. Head Face Med; 2009;5:16
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  • This disease and its complications not only affect the entire body but increase mortality if the pituitary gland tumour remains untreated.
  • [MeSH-minor] Adenoma / complications. Cephalometry. Humans. Macroglossia / etiology. Macroglossia / surgery. Male. Malocclusion, Angle Class III / etiology. Pituitary Neoplasms / complications. Pituitary Neoplasms / surgery. Young Adult

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  • [Cites] Med J Aust. 2004 Apr 19;180(8):419-25 [15089738.001]
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  • (PMID = 19660127.001).
  • [ISSN] 1746-160X
  • [Journal-full-title] Head & face medicine
  • [ISO-abbreviation] Head Face Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2741435
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95. Fernández M, Keyriläinen J, Serimaa R, Torkkeli M, Karjalainen-Lindsberg ML, Leidenius M, von Smitten K, Tenhunen M, Fiedler S, Bravin A, Weiss TM, Suortti P: Human breast cancer in vitro: matching histo-pathology with small-angle x-ray scattering and diffraction enhanced x-ray imaging. Phys Med Biol; 2005 Jul 7;50(13):2991-3006
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  • [Title] Human breast cancer in vitro: matching histo-pathology with small-angle x-ray scattering and diffraction enhanced x-ray imaging.
  • Twenty-eight human breast tumour specimens were studied with small-angle x-ray scattering (SAXS), and 10 of those were imaged by the diffraction enhanced x-ray imaging (DEI) technique.
  • The correspondence between the DEI images, the SAXS maps and the histo-pathology suggests that definitive information on tumour growth and malignancy is obtained by combining these x-ray methods.

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  • (PMID = 15972976.001).
  • [ISSN] 0031-9155
  • [Journal-full-title] Physics in medicine and biology
  • [ISO-abbreviation] Phys Med Biol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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96. de Jonge T, Slullitel H, Dubousset J, Miladi L, Wicart P, Illés T: Late-onset spinal deformities in children treated by laminectomy and radiation therapy for malignant tumours. Eur Spine J; 2005 Oct;14(8):765-71
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  • Surgery consisted of combined anterior and posterior fusion in 39 cases and posterior fusion in seven cases.
  • Nine children did not develop deformity following the primary tumour treatment.
  • The mean scoliotic angle correction was 66 degrees preoperatively to 34 degrees postoperatively.

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  • (PMID = 16012842.001).
  • [ISSN] 0940-6719
  • [Journal-full-title] European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
  • [ISO-abbreviation] Eur Spine J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Other-IDs] NLM/ PMC3489260
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97. Mehrotra N, Behari S, Pal L, Banerji D, Sahu RN, Jain VK: Giant vestibular schwannomas: focusing on the differences between the solid and the cystic variants. Br J Neurosurg; 2008 Aug;22(4):550-6
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  • In vestibular schwannomas (VS), the tumour size, as well as the size of the cystic component, have a considerable bearing on the outcome.
  • The study included 62 patients with giant VSs, of which 40 were solid and 22 were cystic (those in which cystic component greater or equal to 30% of the total tumour volume).
  • The cystic tumour group was further divided into type A (31-60% volume of the cyst within tumour), type B (61-90% intra-tumoural cyst volume) and type C (more than 90% volume of the cyst).
  • In cystic lesions, VIIth nerve preservation was higher due to early decompression of the lesion that facilitated in early identification of the VIIth nerve, except in patients with type C cystic tumour.
  • [MeSH-major] Cerebellopontine Angle / pathology. Neuroma, Acoustic / pathology

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  • (PMID = 18803080.001).
  • [ISSN] 1360-046X
  • [Journal-full-title] British journal of neurosurgery
  • [ISO-abbreviation] Br J Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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98. Lokaj J, Kettmann V, Solčan T, Katuščák S: 1-Methyl-6-nitro-1H-benzimidazole. Acta Crystallogr Sect E Struct Rep Online; 2008;64(Pt 4):o671-2
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  • The title compound, C(8)H(7)N(3)O(2), a potential anti-tumour drug and an anti-oxidant agent, was studied in order to give more insight into structure-function relationships.
  • The 1-methyl-benzimidazole unit of the mol-ecule was found to be exactly planar and the nitro group is inclined at an angle of 10.4 (2)° to the plane of the heterocycle.

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  • (PMID = 21202065.001).
  • [ISSN] 1600-5368
  • [Journal-full-title] Acta crystallographica. Section E, Structure reports online
  • [ISO-abbreviation] Acta Crystallogr Sect E Struct Rep Online
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2961028
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99. Opstad KS, Bell BA, Griffiths JR, Howe FA: An assessment of the effects of sample ischaemia and spinning time on the metabolic profile of brain tumour biopsy specimens as determined by high-resolution magic angle spinning (1)H NMR. NMR Biomed; 2008 Nov;21(10):1138-47
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  • [Title] An assessment of the effects of sample ischaemia and spinning time on the metabolic profile of brain tumour biopsy specimens as determined by high-resolution magic angle spinning (1)H NMR.
  • High-resolution magic angle spinning (HRMAS) (1)H NMR of biopsy tissue provides a biochemical profile that has potential diagnostic and prognostic value, and can aid interpretation of the lower-resolution (1)H-NMR spectra obtained in vivo.
  • In particular, the 18% total creatine increase observed is unlikely to be de novo synthesis of creatine.
  • [MeSH-major] Biomarkers, Tumor / analysis. Brain Ischemia / metabolism. Brain Ischemia / pathology. Brain Neoplasms / metabolism. Brain Neoplasms / pathology. Magnetic Resonance Spectroscopy / methods. Specimen Handling / methods
  • [MeSH-minor] Animals. Biopsy / methods. Cell Line, Tumor. Female. Glioma / metabolism. Glioma / pathology. Humans. Protons. Rats. Rats, Wistar. Reproducibility of Results. Sensitivity and Specificity. Spin Labels

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  • [Copyright] Copyright (c) 2008 John Wiley & Sons, Ltd.
  • (PMID = 18666093.001).
  • [ISSN] 0952-3480
  • [Journal-full-title] NMR in biomedicine
  • [ISO-abbreviation] NMR Biomed
  • [Language] eng
  • [Grant] United Kingdom / Cancer Research UK / / C1459/A2592
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Protons; 0 / Spin Labels
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100. Martínez A, Lorenzo J, Prieto MJ, Font-Bardia M, Solans X, Avilés FX, Moreno V: Influence of the position of substituents in the cytotoxic activity of trans platinum complexes with hydroxymethyl pyridines. Bioorg Med Chem; 2007 Jan 15;15(2):969-79
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  • The values of the dihedral angle (85 degrees , 57 degrees and 42 degrees for 1, 2 and 3, respectively) demonstrate how important is the position of substituent from a structural point of view.
  • Studies of antiproliferative activity of complexes 1 and 2 against cell tumour lines (HL-60) and apoptosis assays have also been carried out, showing that 1 as well as 2 are far less active than the previously described complex 3 (IC(50)=19; 19 and 3 microM, respectively).

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  • (PMID = 17088064.001).
  • [ISSN] 0968-0896
  • [Journal-full-title] Bioorganic & medicinal chemistry
  • [ISO-abbreviation] Bioorg. Med. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Indicators and Reagents; 0 / Organoplatinum Compounds; 0 / Pyridines; 9007-49-2 / DNA
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