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1. Moore SW, Davidson A, Hadley GP, Kruger M, Poole J, Stones D, Wainwright L, Wessels G: Malignant liver tumors in South African children: a national audit. World J Surg; 2008 Jul;32(7):1389-95
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant liver tumors in South African children: a national audit.
  • BACKGROUND: Malignant liver tumors (mostly hepatoblastoma [HB] and hepatocellular carcinoma [HCC]) are uncommon, representing 0.5%-2% of childhood malignancies worldwide.
  • The pattern of liver tumors appears to differ in Southern Africa as a result of infectious factors (e.g., hepatitis B/retroviral disease (HIV).
  • METHODS: Data were obtained from the tumor registry and pediatric oncology units in South African hospitals to audit and review the epidemiology, treatment, and outcome of malignant hepatic tumors in South African children.
  • RESULTS: Malignant primary hepatic tumors were reported in 274 children (ages 0-14 years) from 1988 through June 2006.
  • Of these 134 (48%) had HB; 77 (27%) had HCC (9 [3%] fibrolamellar subtype); 38 (13%), vascular tumors; and 17 (6%), liver sarcomas.
  • Vascular tumors included hemangioendotheliomas (12), and there were 5 malignant tumors in children with HIV, including 1 angiosarcoma and 13 Kaposi sarcoma-like tumors.
  • Hepatic sarcoma occurred at a mean age of 7.66 years and had a female predominance (M:F ratio: 0.4).
  • There appeared to be an increase in the incidence of vascular tumors, presumably the result of an increase in Kaposi-like sarcoma in retrovirus-positive patients.
  • The surgical resection rate was low because most patients presented late, with advanced disease.
  • Retroviral disease does not yet appear to have a major influence on the distribution of liver tumors in South Africa, although it possibly affects the vascular tumor prevalence.

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  • (PMID = 18305988.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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2. Guirguis A, Kanbour-Shakir A, Kelley J: Epithelioid angiosarcoma of the mons after chemoradiation for vulvar cancer. Int J Gynecol Pathol; 2007 Jul;26(3):265-8
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  • [Title] Epithelioid angiosarcoma of the mons after chemoradiation for vulvar cancer.
  • Angiosarcomas are rare malignant tumors of endothelial origin with morphological properties similar to the vascular and lymphatic endothelium.
  • Our patient is the first case report of an angiosarcoma of the mons pubis after chemoradiation and the second reported angiosarcoma of the mons.
  • She presented 4 years later with a lesion on her mons, consistent with an angiosarcoma.
  • Angiosarcomas are rare malignant tumors of endothelial origin with morphological properties similar to the vascular and lymphatic endothelium.
  • Our patient is the first case report of an angiosarcoma of the mons pubis after chemoradiation for vulvar cancer and the second reported angiosarcoma of the mons.
  • As the treatment of vulvar cancer evolves, and more radiation therapy is given, the incidence of angiosarcomas will rise, requiring better diagnostic and treatment protocols.
  • [MeSH-major] Hemangiosarcoma / pathology. Vulvar Neoplasms / pathology

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  • (PMID = 17581409.001).
  • [ISSN] 0277-1691
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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3. Yanada M, Shimada J, Ito K, Terauchi K, Shimomura M: [Cardiac angiosarcoma with diagnostic difficulty]. Kyobu Geka; 2007 Dec;60(13):1148-51
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  • [Title] [Cardiac angiosarcoma with diagnostic difficulty].
  • We report a case of cardiac angiosarcoma of the right atrium.
  • Therefore a CT-guided transthoracic needle biopsy under CT fluoroscopic guidance for definitive diagnosis was performed after obtaining the patient's informed consent.
  • Pathohistologically, the tumor was diagnosed as a cardiac angiosarcoma.
  • [MeSH-major] Heart Neoplasms / diagnosis. Hemangiosarcoma / diagnosis

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  • (PMID = 18078079.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / CA-125 Antigen
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4. Salameire D, Laverrière MH, Ferretti G, Brichon PY, Lantuéjoul S: [Pathology of primary tumors and pseudotumors of the pleura]. Rev Pneumol Clin; 2006 Apr;62(2):80-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Histological types include mesothelioma, epitheliod, biphasic or sarcomatoid tumors as well as primary lymphoma and mesenchymatous tumors which include solitary fibrous tumor, epithelioid hemangioendothelioma and angiosarcoma and synovialosarcoma.
  • [MeSH-minor] Hemangioendothelioma, Epithelioid / pathology. Humans. Lymphoma / pathology. Mesothelioma / pathology. Neoplasm Staging. Neoplasms, Connective Tissue / pathology. World Health Organization

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  • (PMID = 16670660.001).
  • [ISSN] 0761-8417
  • [Journal-full-title] Revue de pneumologie clinique
  • [ISO-abbreviation] Rev Pneumol Clin
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 13
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5. Serrano C, García Á, Brana I, Pérez-Benavente A, Oaknin A: Angiosarcoma of the ovary: is it always a lethal disease? J Clin Oncol; 2010 Nov 20;28(33):e675-7
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  • [Title] Angiosarcoma of the ovary: is it always a lethal disease?
  • [MeSH-major] Hemangiosarcoma / diagnosis. Ovarian Neoplasms / diagnosis

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  • (PMID = 20823420.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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6. Long CT, Luong R: What's your diagnosis. Tail mass in a mouse. Cutaneous hemangiosarcoma. Lab Anim (NY); 2009 Feb;38(2):49-51
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  • [Title] What's your diagnosis. Tail mass in a mouse. Cutaneous hemangiosarcoma.
  • [MeSH-major] Hemangiosarcoma / veterinary. Skin Neoplasms / veterinary
  • [MeSH-minor] Angiomatosis / diagnosis. Animals. Animals, Outbred Strains. Diagnosis, Differential. Fatal Outcome. Female. Hemangioma / diagnosis. Hematoma / diagnosis. Mice. Tail

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  • (PMID = 19165190.001).
  • [ISSN] 0093-7355
  • [Journal-full-title] Lab animal
  • [ISO-abbreviation] Lab Anim (NY)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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7. Chen TJ, Chiou CC, Chen CH, Kuo TT, Hong HS: Metastasis of mediastinal epithelioid angiosarcoma to the finger. Am J Clin Dermatol; 2008;9(3):181-3
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  • [Title] Metastasis of mediastinal epithelioid angiosarcoma to the finger.
  • Epithelioid angiosarcoma (EA) is a rare malignant, vascular tumor that is usually observed in middle-aged and elderly males.
  • Whenever a patient has metastatic disease, acrometastases should be considered in the differential diagnosis of inflammatory lesions of the digits and a skin biopsy should be performed.
  • [MeSH-major] Fingers / pathology. Hemangioendothelioma, Epithelioid / secondary. Mediastinal Neoplasms / pathology. Skin Neoplasms / secondary
  • [MeSH-minor] Adult. Biopsy. Diagnosis, Differential. Fatal Outcome. Female. Humans

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  • (PMID = 18429648.001).
  • [ISSN] 1175-0561
  • [Journal-full-title] American journal of clinical dermatology
  • [ISO-abbreviation] Am J Clin Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] New Zealand
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8. Fuller CK, Charlson JA, Dankle SK, Russell TJ: Dramatic improvement of inoperable angiosarcoma with combination paclitaxel and bevacizumab chemotherapy. J Am Acad Dermatol; 2010 Oct;63(4):e83-4
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  • [Title] Dramatic improvement of inoperable angiosarcoma with combination paclitaxel and bevacizumab chemotherapy.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Facial Neoplasms / drug therapy. Facial Neoplasms / pathology. Hemangiosarcoma / drug therapy. Hemangiosarcoma / pathology

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  • (PMID = 20846560.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 2S9ZZM9Q9V / Bevacizumab; P88XT4IS4D / Paclitaxel
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9. Salomäki HH, Sainio AO, Söderström M, Pakkanen S, Laine J, Järveläinen HT: Differential expression of decorin by human malignant and benign vascular tumors. J Histochem Cytochem; 2008 Jul;56(7):639-46
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  • [Title] Differential expression of decorin by human malignant and benign vascular tumors.
  • Given that angiogenesis is a sine qua non for tumor growth and progression, we attempted to examine whether human malignant vascular tumors differ from human benign vascular tumors in terms of their decorin expression and synthesis.
  • CD31 immunostaining demonstrated that the human malignant vascular tumors Kaposi's sarcoma and angiosarcoma were filled with capillary-like structures, whereas in benign cavernous and capillary hemangiomas, blood vessels were not as abundantly present.
  • By utilizing in situ hybridization and immunocytochemical assays for decorin, we showed that there was no detectable decorin mRNA expression or immunoreactivity within the tumor mass in the Kaposi's sarcoma or angiosarcoma group.
  • Instead, decorin was expressed in the connective tissue stroma lining the sarcoma tissue.
  • In contrast to sarcomas, in hemangiomas, decorin mRNA expression and immunoreactivity were observed also within the tumor mass, particularly in the connective tissue stroma surrounding the clusters of intratumoral blood vessels.
  • In sarcomas, angiogenesis is extremely powerful, whereas in hemangiomas, angiogenesis has ceased.
  • Decorin certainly provides a usable biomarker for distinguishing between benign and malignant vascular tumors in patients.
  • [MeSH-major] Extracellular Matrix Proteins / biosynthesis. Hemangioma, Capillary / metabolism. Hemangioma, Cavernous / metabolism. Hemangiosarcoma / metabolism. Proteoglycans / biosynthesis. Sarcoma, Kaposi / metabolism. Skin Neoplasms / metabolism

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  • (PMID = 18413650.001).
  • [ISSN] 0022-1554
  • [Journal-full-title] The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
  • [ISO-abbreviation] J. Histochem. Cytochem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Collagen Type I; 0 / DCN protein, human; 0 / Decorin; 0 / Extracellular Matrix Proteins; 0 / Proteoglycans; 0 / RNA, Messenger; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
  • [Other-IDs] NLM/ PMC2430166
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10. Tate G, Suzuki T, Mitsuya T: Mutation of the PTEN gene in a human hepatic angiosarcoma. Cancer Genet Cytogenet; 2007 Oct 15;178(2):160-2
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  • [Title] Mutation of the PTEN gene in a human hepatic angiosarcoma.
  • The PTEN protein inhibits angiogenesis, and somatic mutations of the PTEN gene are involved in canine hemangiosarcoma.
  • We screened for mutations of the PTEN gene in two patients with human hepatic angiosarcoma to determine whether PTEN is involved in the pathogenesis of human hepatic angiosarcoma.
  • In one patient, who suffered from breast cancer, pharyngeal cancer, and hepatic angiosarcoma, we found a single base substitution in exon 7 (640C>T) of the PTEN gene in both the hepatic angiosarcoma and normal tissues.
  • These findings indicate that analysis of PTEN gene mutations may be useful for characterization of the molecular event in hepatic angiosarcoma and cancer predisposition.
  • [MeSH-major] Hemangiosarcoma / genetics. Liver Neoplasms / genetics. Mutation. PTEN Phosphohydrolase / genetics
  • [MeSH-minor] Aged. Breast Neoplasms / genetics. Breast Neoplasms / pathology. Female. Genetic Predisposition to Disease. Humans. Immunohistochemistry. Male. Middle Aged. Pharyngeal Neoplasms / genetics. Pharyngeal Neoplasms / pathology. Polymerase Chain Reaction

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  • (PMID = 17954274.001).
  • [ISSN] 0165-4608
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.1.3.48 / PTEN protein, human; EC 3.1.3.67 / PTEN Phosphohydrolase
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11. Requena L, Santonja C, Stutz N, Kaddu S, Weenig RH, Kutzner H, Menzel T, Cerroni L: Pseudolymphomatous cutaneous angiosarcoma: a rare variant of cutaneous angiosarcoma readily mistaken for cutaneous lymphoma. Am J Dermatopathol; 2007 Aug;29(4):342-50
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  • [Title] Pseudolymphomatous cutaneous angiosarcoma: a rare variant of cutaneous angiosarcoma readily mistaken for cutaneous lymphoma.
  • Cutaneous angiosarcoma is probably the most malignant neoplasm involving the skin.
  • Three clinical variants of cutaneous angiosarcoma are recognized, including angiosarcoma of the scalp and face of elderly patients, angiosarcoma associated with chronic lymphedema, and postirradiation angiosarcoma.
  • Histopathologically, these three variants of angiosarcoma show similar features, which consist of poorly circumscribed, irregularly dilated, and anastomosing vascular channels lined by prominent endothelial cells that dissect through the dermis.
  • Focally, neoplastic endothelial cells show large, hyperchromatic, and pleomorphic nuclei, protruding within vascular lumina and creating small papillations.
  • In rare instances, cutaneous angiosarcomas may exhibit prominent inflammatory infiltrate, and the neoplasm may be mistaken for an inflammatory process, both from clinical and histopathologic points of view.
  • We describe four examples of cutaneous angiosarcomas with dense lymphocytic infiltrates involving the neoplasm.
  • The neoplastic endothelial cells expressed immunoreactivity for the CD31, CD34, podoplanin, Prox-1, Lyve-1, and D2-40.
  • We discuss the possible relationship between neoplastic endothelial lymphatic cells and reactive lymphocytes.
  • Cutaneous angiosarcoma with prominent lymphocytic infiltrate may be readily mistaken for cutaneous follicle center cell lymphoma or cutaneous pseudolymphoma.
  • [MeSH-major] Hemangiosarcoma / diagnosis. Lymphoma / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged. Breast Neoplasms / diagnosis. Diagnosis, Differential. Endothelial Cells / pathology. Endothelium, Vascular / pathology. Facial Neoplasms / diagnosis. Female. Humans. Lymphocytes / pathology. Lymphoma, Follicular / diagnosis. Male. Middle Aged. Neovascularization, Pathologic / pathology. Pseudolymphoma / diagnosis. Scalp / pathology. Skin Diseases / diagnosis

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  • (PMID = 17667166.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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12. El-Osta HE, Yammine YS, Chehab BM, Fields AS, Moore DF Jr, Mattar BI: Unexplained hemopericardium as a presenting feature of primary cardiac angiosarcoma: a case report and a review of the diagnostic dilemma. J Thorac Oncol; 2008 Jul;3(7):800-2
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  • [Title] Unexplained hemopericardium as a presenting feature of primary cardiac angiosarcoma: a case report and a review of the diagnostic dilemma.
  • This report describes a patient diagnosed with a cardiac angiosarcoma.
  • His pericardial effusion recurred 3 weeks later, at which time he was found to have a large right atrial mass which proved to be a cardiac angiosarcoma.
  • This case report underscores the difficulties encountered in the diagnosis of cardiac angiosarcoma.
  • [MeSH-major] Heart Neoplasms / complications. Hemangiosarcoma / complications. Pericardial Effusion / etiology

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  • (PMID = 18594329.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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13. Sattout AH, Deolekar MV, Tait WF, Williams GT: Femoral artery angiosarcoma presenting with distal embolization: report of a case. Surg Today; 2008;38(6):541-4
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  • [Title] Femoral artery angiosarcoma presenting with distal embolization: report of a case.
  • Angiosarcoma of the femoral artery is an extremely rare malignant vascular tumor.
  • The initial diagnosis is difficult to establish and distal metastasis can sometimes be the only presenting symptom.
  • In this paper, we report the case of a 54-year-old man who presented with multiple painful necrotic lesions over the right foot secondary to an intimal angiosarcoma of the right common femoral artery.
  • [MeSH-major] Femoral Artery. Hemangiosarcoma / pathology. Neoplastic Cells, Circulating / pathology. Vascular Neoplasms / pathology

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  • [Cites] Abdom Imaging. 2004 Jul-Aug;29(4):507-10 [15136894.001]
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  • (PMID = 18516535.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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14. Culp WT, Weisse C, Kellogg ME, Gordon IK, Clarke DL, May LR, Drobatz KJ: Spontaneous hemoperitoneum in cats: 65 cases (1994-2006). J Am Vet Med Assoc; 2010 May 1;236(9):978-82
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  • Cats were included if a definitive diagnosis of spontaneous hemoperitoneum could be obtained from review of the medical records.
  • Hemangiosarcoma was the most often diagnosed neoplasm (18/30; 60%), and the spleen was the most common location for neoplasia (11/30; 37%).
  • Cats with neoplasia were significantly older and had significantly lower PCVs than cats with non-neoplastic disease.

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  • (PMID = 20433398.001).
  • [ISSN] 0003-1488
  • [Journal-full-title] Journal of the American Veterinary Medical Association
  • [ISO-abbreviation] J. Am. Vet. Med. Assoc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. Chuang SC, La Vecchia C, Boffetta P: Liver cancer: descriptive epidemiology and risk factors other than HBV and HCV infection. Cancer Lett; 2009 Dec 1;286(1):9-14
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  • Given the poor survival from this disease, the estimated number of deaths is similar to that of new cases.
  • Angiosarcoma is a rare form of liver cancer whose occurence is linked to occupational exposure to vinyl chloride.

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  • (PMID = 19091458.001).
  • [ISSN] 1872-7980
  • [Journal-full-title] Cancer letters
  • [ISO-abbreviation] Cancer Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Aflatoxins; 0 / Contraceptives, Oral
  • [Number-of-references] 48
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16. Sutton VR, Hopkins BJ, Eble TN, Gambhir N, Lewis RA, Van den Veyver IB: Facial and physical features of Aicardi syndrome: infants to teenagers. Am J Med Genet A; 2005 Oct 15;138A(3):254-8
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  • Aicardi syndrome is a sporadic disorder that affects primarily females and is hypothesized to be caused by heterozygous mutations in an X-linked gene.
  • Various skin lesions (including multiple nevi, skin tags, hemangiomas, one giant melanotic nevus, and a history of a previously removed angiosarcoma) were present in 8/40 (20%).


17. Mignogna C, Simonetti S, Galloro G, Magno L, De Cecio R, Insabato L: Duodenal epithelioid angiosarcoma: immunohistochemical and clinical findings. A case report. Tumori; 2007 Nov-Dec;93(6):619-21
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  • [Title] Duodenal epithelioid angiosarcoma: immunohistochemical and clinical findings. A case report.
  • Angiosarcomas are uncommon malignant tumors of vascular endothelium that represent less than 1% of all sarcomas.
  • The epithelioid variant of angiosarcomas is exceptionally rare, and the gastrointestinal tract is rarely involved.
  • Angiosarcomas mainly involve skin and soft tissue and rarely occur in breast, liver, bone, and spleen.
  • A duodenal reddish polypoid lesion was found, which on microscopic examination turned out to be an epithelioid angiosarcoma.
  • The immunohistochemical features of the lesion supported this diagnosis.
  • The patient died eight months after the diagnosis.
  • Epithelioid angiosarcoma is an aggressive variant of angiosarcoma and must be considered in the differential diagnosis of gastrointestinal tumors.
  • [MeSH-major] Duodenal Neoplasms / pathology. Hemangioendothelioma, Epithelioid / pathology. Hemangiosarcoma / pathology

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  • (PMID = 18338501.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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18. Tayeb T, Bouzaiene M: [Epithelioid hemangioendothelioma mimicking an occipital artery aneurysm]. Rev Stomatol Chir Maxillofac; 2007 Nov;108(5):451-4
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  • [Title] [Epithelioid hemangioendothelioma mimicking an occipital artery aneurysm].
  • INTRODUCTION: Epithelioid hemangioendothelioma (EHE) is a unique tumor of soft tissues, primarily occurring in adults.
  • It is characterized by the proliferation of epithelioid or histiocytoid endothelial cells.
  • Its clinical course being close to that of hemangioma and conventional angiosarcoma, the term epithelioid hemangioendothelioma was suggested.
  • CASE REPORT: The authors report the case of 29-year-old women complaining of a right occipital nodule of the scalp, diagnosed later as an epithelioid hemangioendothelioma located in the scalp and appearing like an aneurysm of the occipital artery on clinical examination and on radiological investigations.
  • Finally it was the histological examination which confirmed the diagnosis of epithelioid hemangioendothelioma.
  • Epithelioid hemangioendotheliomas belong to the epithelioid vascular tumor spectrum.
  • They have in common the morphologic epithelioid aspect of endothelial tumor cells.
  • [MeSH-major] Aneurysm / diagnosis. Head and Neck Neoplasms / diagnosis. Hemangioendothelioma, Epithelioid / diagnosis. Scalp / blood supply. Scalp / pathology
  • [MeSH-minor] Adult. Arteries. Diagnosis, Differential. Female. Humans. Occipital Bone

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  • (PMID = 17916371.001).
  • [ISSN] 0035-1768
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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19. Rudisaile SN, Hurt MA, Santa Cruz DJ: Granular cell atypical fibroxanthoma. J Cutan Pathol; 2005 Apr;32(4):314-7
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  • The differential diagnosis of granular cells in neoplasms containing cytological pleomorphism is challenging in view of the many different neoplasms that may present with granular cytoplasm.
  • These include the conventional granular cell tumor and its malignant form, leiomyoma, leiomyosarcoma, dermatofibroma, dermatofibrosarcoma protuberans, and angiosarcoma.

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  • (PMID = 15769283.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 25
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20. Warman SM, McGregor R, Fews D, Ferasin L: Congestive heart failure caused by intracardiac tumours in two dogs. J Small Anim Pract; 2006 Aug;47(8):480-3
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  • Case 1 showed signs of left-sided heart failure caused by osteosarcoma within the left atrial lumen, and case 2 presented with clinical signs of right-sided heart failure due to haemangiosarcoma occupying the right atrial and ventricular lumens.
  • This case report provides further evidence for the inclusion of intracardiac neoplasia in the differential diagnosis for dogs with clinical signs of congestive heart failure.
  • [MeSH-major] Dog Diseases / diagnosis. Heart Failure / veterinary. Heart Neoplasms / veterinary. Hemangiosarcoma / veterinary. Osteosarcoma / veterinary

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  • (PMID = 16911120.001).
  • [ISSN] 0022-4510
  • [Journal-full-title] The Journal of small animal practice
  • [ISO-abbreviation] J Small Anim Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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21. Zidar N, Gale N, Zupevc A, Dovsak D: Pseudovascular adenoid squamous-cell carcinoma of the oral cavity--a report of two cases. J Clin Pathol; 2006 Nov;59(11):1206-8
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  • Two cases of pseudovascular adenoid squamous-cell carcinoma (SCC) in the oral cavity are described, which were characterised by acantholysis of the tumour cells, with formation of anastomosing spaces and channels mimicking an angiosarcoma.
  • Both tumours contained foci of SCC suggesting the correct diagnosis: in one patient conventional SCC, and in the other, a spindle-cell carcinoma.
  • [MeSH-minor] Aged. Cadherins / metabolism. Diagnosis, Differential. Female. Hemangiosarcoma / pathology. Humans. Male. Middle Aged. Neoplasm Proteins / metabolism


22. Azimi NA, Selter JG, Abott JD, Cabin HS, Hutner A, Copel J, Setaro JF: Angiosarcoma in a pregnant woman presenting with pericardial tamponade--a case report and review of the literature. Angiology; 2006 Mar-Apr;57(2):251-7
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  • [Title] Angiosarcoma in a pregnant woman presenting with pericardial tamponade--a case report and review of the literature.
  • The authors present a rare case of pericardial tamponade complicating pregnancy with resulting diagnosis of angiosarcoma.
  • They review the literature involving pericardial disease in pregnancy and discuss important issues in management and include a discussion of angiosarcoma.
  • [MeSH-major] Cardiac Tamponade / etiology. Heart Neoplasms / complications. Hemangiosarcoma / complications. Pregnancy Complications, Neoplastic
  • [MeSH-minor] Adult. Biopsy. Cardiac Surgical Procedures / methods. Diagnosis, Differential. Echocardiography. Female. Follow-Up Studies. Heart Atria. Humans. Magnetic Resonance Imaging. Pericardial Effusion / complications. Pericardial Effusion / diagnosis. Pericardial Effusion / surgery. Pregnancy. Tomography, X-Ray Computed

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  • (PMID = 16518537.001).
  • [ISSN] 0003-3197
  • [Journal-full-title] Angiology
  • [ISO-abbreviation] Angiology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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23. Moe M, Bertelli G: Breast angiosarcoma following lumpectomy and radiotherapy for breast cancer: a case with short latent period and false negative result on biopsies. Ann Oncol; 2007 Apr;18(4):801
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  • [Title] Breast angiosarcoma following lumpectomy and radiotherapy for breast cancer: a case with short latent period and false negative result on biopsies.

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  • [CommentIn] Ann Oncol. 2007 Apr;18(4):619-21 [17351257.001]
  • (PMID = 17229767.001).
  • [ISSN] 0923-7534
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Letter
  • [Publication-country] England
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24. Lee NK, Kim S, Kim GH, Jeon TY, Kim DH, Jang HJ, Park DY: Hypervascular subepithelial gastrointestinal masses: CT-pathologic correlation. Radiographics; 2010 Nov;30(7):1915-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Entities that appear as intramural hypervascular subepithelial lesions include neuroendocrine tumors, GI stromal tumor, glomus tumor, hemangioma, angiosarcoma, Kaposi sarcoma, nerve sheath tumors, hypervascular metastases, heterotopic tissues, and vascular structures.
  • Entities that appear as extramural hypervascular subepithelial lesions include Castleman disease, solitary fibrous tumor, inflammatory myofibroblastic tumor, and actinomycosis.
  • Familiarity with the characteristic CT appearances of hypervascular subepithelial masses of the GI tract will help radiologists make a more confident diagnosis.

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  • [Copyright] © RSNA, 2010.
  • (PMID = 21057127.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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25. Yu K, Liu Y, Wang H, Hu S, Long C: Epidemiological and pathological characteristics of cardiac tumors: a clinical study of 242 cases. Interact Cardiovasc Thorac Surg; 2007 Oct;6(5):636-9
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  • Of primary cardiac tumors, the incidence of benign neoplasm was much higher than malignant masses (90.6% vs. 9.4%, P<0.01).
  • Mesenchymoma and angiosarcoma were the most common primary malignant cardiac tumors.
  • The primary malignant tumors have a tendency to be of multi-center origination (23%).
  • [MeSH-major] Asian Continental Ancestry Group / statistics & numerical data. Heart Neoplasms. Hemangiosarcoma. Lipoma. Mesenchymoma. Myxoma. Rhabdomyoma

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  • (PMID = 17670730.001).
  • [ISSN] 1569-9285
  • [Journal-full-title] Interactive cardiovascular and thoracic surgery
  • [ISO-abbreviation] Interact Cardiovasc Thorac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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26. Blankenburg F, Scheer I, Sarioglu N, Henze G, Driever PH, Riebel T: Spontaneous regression of a vascular tumor of the skull base--infantile hemangioendothelioma? J Pediatr Hematol Oncol; 2008 Sep;30(9):712-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spontaneous regression of a vascular tumor of the skull base--infantile hemangioendothelioma?
  • Histopathologically, vessel malformation, epitheloid hemangioendothelioma, and angiosarcoma were possible diagnoses.
  • Retrospectively, histologic and radiologic findings and clinical course prompted the diagnosis of an infantile hemangioendothelioma.
  • To our knowledge, this is the first report on an infantile hemangioendothelioma of the skull base.
  • [MeSH-major] Hemangioendothelioma / diagnosis. Neoplasm Regression, Spontaneous. Skull Base / blood supply. Vascular Neoplasms / diagnosis

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  • (PMID = 18776768.001).
  • [ISSN] 1536-3678
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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27. Pirie CG, Dubielzig RR: Feline conjunctival hemangioma and hemangiosarcoma: a retrospective evaluation of eight cases (1993-2004). Vet Ophthalmol; 2006 Jul-Aug;9(4):227-31
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  • [Title] Feline conjunctival hemangioma and hemangiosarcoma: a retrospective evaluation of eight cases (1993-2004).
  • The purpose of this retrospective study was to evaluate feline primary conjunctival vascular tumors of endothelial origin.
  • Eight cases (six hemangiomas, two hemangiosarcomas) from a collection of 3460 feline submissions between 1993 and 2004 were evaluated using routine hematoxylin and eosin (H&E).
  • Only cases of hemangiosarcoma underwent surgical re-excisions following incomplete excision; however, no further recurrences were reported.
  • No cases evaluated had evidence of metastatic disease at the time of excision.
  • [MeSH-major] Cat Diseases / epidemiology. Conjunctival Neoplasms / veterinary. Hemangioma / veterinary. Hemangiosarcoma / veterinary

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  • (PMID = 16771757.001).
  • [ISSN] 1463-5216
  • [Journal-full-title] Veterinary ophthalmology
  • [ISO-abbreviation] Vet Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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28. Plotnik AN, Schweder P, Tsui A, Kavar B: Splenic angiosarcoma metastasis to the brain. J Clin Neurosci; 2008 Aug;15(8):927-9
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  • [Title] Splenic angiosarcoma metastasis to the brain.
  • Angiosarcoma is a rare primary non-haematolymphoid malignant neoplasm of the spleen.
  • This neoplastic process has a poor prognosis, with disease usually widespread by the time of presentation.
  • In the literature there has been only six case reports of cerebral metastasis from splenic angiosarcomas.
  • We report a 61-year-old woman who presented with a right occipital metastasis of a splenic angiosarcoma, 5 years after initial diagnosis, treated by stereotactic occipital craniotomy and resection of metastasis.
  • [MeSH-major] Brain Neoplasms / secondary. Hemangiosarcoma / pathology. Splenic Neoplasms / pathology

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  • (PMID = 18411053.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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29. de Giorgi V, Santi R, Grazzini M, Papi F, Gori A, Rossari S, Massi D, Lotti T: Synchronous angiosarcoma, melanoma and morphea of the breast skin 14 years after radiotherapy for mammary carcinoma. Acta Derm Venereol; 2010 May;90(3):283-6
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  • [Title] Synchronous angiosarcoma, melanoma and morphea of the breast skin 14 years after radiotherapy for mammary carcinoma.
  • We describe here the case of a 68-year-old woman who developed synchronous cutaneous angiosarcoma, melanoma and morphea of the breast skin and the local area, 14 years after radiotherapy for breast carcinoma.
  • Radiation-induced morphea is a rare complication in which immunological abnormalities may stimulate malignant transformation.
  • [MeSH-major] Breast Neoplasms / radiotherapy. Carcinoma / radiotherapy. Hemangiosarcoma / etiology. Melanoma / etiology. Neoplasms, Radiation-Induced / etiology. Neoplasms, Second Primary / etiology. Scleroderma, Localized / etiology. Skin Neoplasms / etiology


30. Lucas DR: Angiosarcoma, radiation-associated angiosarcoma, and atypical vascular lesion. Arch Pathol Lab Med; 2009 Nov;133(11):1804-9
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  • [Title] Angiosarcoma, radiation-associated angiosarcoma, and atypical vascular lesion.
  • Angiosarcoma, one of the least common sarcomas, has become increasingly important because of its association with radiation therapy, especially for breast cancer.
  • However, angiosarcoma has a wide anatomic distribution including soft tissue, visceral organ, and osseous locations.
  • Radiation-associated angiosarcoma typically presents as a cutaneous tumor several years posttherapy.
  • The latency for radiation-associated mammary angiosarcoma is relatively short, sometimes less than 3 years.
  • Although most atypical vascular lesions pursue a benign course, they recur and very rarely progress to angiosarcoma.
  • Distinguishing this lesion from well-differentiated angiosarcoma in a biopsy can be challenging, especially because areas indistinguishable from atypical vascular lesion are found adjacent to angiosarcoma.
  • [MeSH-major] Hemangioma / pathology. Hemangiosarcoma / pathology. Neoplasms, Radiation-Induced / pathology. Skin Neoplasms / pathology. Vascular Diseases / pathology

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  • (PMID = 19886715.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 12
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31. Schwab J, Haack G, Wünsch PH, Bär I, Zahn R: Cardiac angiosarcoma: case report and review of the literatur : R. R. Brandt, R. Arnold, R.M. Bohle, T. Dill, C.W. Hamm; Z Kardiol 94:824-828 (2005). Clin Res Cardiol; 2006 Jun;95(6):351-2; author reply 352-3
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  • [Title] Cardiac angiosarcoma: case report and review of the literatur : R. R. Brandt, R. Arnold, R.M. Bohle, T. Dill, C.W. Hamm; Z Kardiol 94:824-828 (2005).
  • [MeSH-major] Heart Neoplasms / pathology. Hemangiosarcoma / pathology. Magnetic Resonance Imaging

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  • [CommentOn] Z Kardiol. 2005 Dec;94(12):824-8 [16382384.001]
  • [Cites] Radiographics. 1999 Nov-Dec;19(6):1421-34 [10555666.001]
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  • (PMID = 16741594.001).
  • [ISSN] 1861-0684
  • [Journal-full-title] Clinical research in cardiology : official journal of the German Cardiac Society
  • [ISO-abbreviation] Clin Res Cardiol
  • [Language] eng
  • [Publication-type] Case Reports; Comment; Letter
  • [Publication-country] Germany
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32. Veliz M, Chang V, Kasimis B, Choe JK: Durable response of angiosarcoma of the face and scalp to docetaxel. Clin Oncol (R Coll Radiol); 2007 Apr;19(3):210
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  • [Title] Durable response of angiosarcoma of the face and scalp to docetaxel.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Hemangiosarcoma / drug therapy. Skin Neoplasms / drug therapy. Taxoids / therapeutic use

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  • (PMID = 17359910.001).
  • [ISSN] 0936-6555
  • [Journal-full-title] Clinical oncology (Royal College of Radiologists (Great Britain))
  • [ISO-abbreviation] Clin Oncol (R Coll Radiol)
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Taxoids; 15H5577CQD / docetaxel
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33. Castillo JG, Silvay G: Characterization and management of cardiac tumors. Semin Cardiothorac Vasc Anesth; 2010 Mar;14(1):6-20
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  • Among malignant primary cardiac tumors, the most reported are those histopathologically considered as undifferentiated, followed by angiosarcomas and leiomyosarcomas.
  • [MeSH-minor] Adult. Child. Echocardiography / methods. Fibroma / diagnosis. Fibroma / pathology. Fibroma / therapy. Humans. Magnetic Resonance Imaging / methods. Rhabdomyoma / diagnosis. Rhabdomyoma / pathology. Rhabdomyoma / therapy. Time Factors

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  • (PMID = 20472615.001).
  • [ISSN] 1940-5596
  • [Journal-full-title] Seminars in cardiothoracic and vascular anesthesia
  • [ISO-abbreviation] Semin Cardiothorac Vasc Anesth
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 81
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34. Hofmann UB, Wobser M, Kneitz H, Kleine P, Becker JC, Bröcker EB, Ugurel S: Major response to paclitaxel combined with irradiation as second-line therapy in metastatic angiosarcoma of the face and scalp. Br J Dermatol; 2009 Feb;160(2):456-8
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  • [Title] Major response to paclitaxel combined with irradiation as second-line therapy in metastatic angiosarcoma of the face and scalp.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Head and Neck Neoplasms. Hemangiosarcoma. Scalp

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  • (PMID = 19077074.001).
  • [ISSN] 1365-2133
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 80168379AG / Doxorubicin; P88XT4IS4D / Paclitaxel
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35. Itakura E, Yamamoto H, Oda Y, Tsuneyoshi M: Detection and characterization of vascular endothelial growth factors and their receptors in a series of angiosarcomas. J Surg Oncol; 2008 Jan 1;97(1):74-81
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  • [Title] Detection and characterization of vascular endothelial growth factors and their receptors in a series of angiosarcomas.
  • BACKGROUND: Angiosarcomas are malignant mesenchymal neoplasms, including sarcomas of presumptive vascular endothelial origin and sarcomas of probable lymphatic origin.
  • The majority of angiosarcomas are thought to originate from vascular endothelia and spread via bloodstream to lung, but lymphatic metastases can occur.
  • METHODS: We investigated immunohistochemical expression of vascular endothelial growth factors (VEGF-A, VEGF-C) and their receptors (VEGFR-1, VEGFR-2, VEGFR-3) in a series of 34 angiosarcomas.
  • CONCLUSIONS: VEGF-A and VEGFR-1 were detected in diverse subtypes of angiosarcomas.
  • In cooperation, VEGF-A and VEGF-C are likely to be involved in the development of angiosarcoma associated with lymphedema.
  • Angiosarcoma of the scalp, which is traditionally considered as a true hemangiosarcoma, may include some cases of lymphatic origin.
  • [MeSH-major] Hemangiosarcoma / chemistry. Receptors, Vascular Endothelial Growth Factor / analysis. Vascular Endothelial Growth Factor A / analysis

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  • [Copyright] (c) 2007 Wiley-Liss, Inc.
  • (PMID = 18041747.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Vascular Endothelial Growth Factor A; EC 2.7.10.1 / Receptors, Vascular Endothelial Growth Factor
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36. Tyson M, French M, McNulty N, Lerner L: A case of severe bladder wall hypertrophy: bladder cancer or sequela of bladder outlet obstruction? Can J Urol; 2009 Feb;16(1):4516-8
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  • Angiosarcomas are soft tissue malignancies of connective tissue origin with rapid hematogenous spread, but are extremely uncommon primary tumors of the bladder with approximately ten reported cases in the 20th century.
  • This case serves as a unique example of how the sequelae of bladder outlet obstruction (BOO) can resemble a malignant process on presentation but represent no more than hypertrophic adaptations in the bladder wall musculature of a patient with BPH and significant outlet obstruction.

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  • (PMID = 19222895.001).
  • [ISSN] 1195-9479
  • [Journal-full-title] The Canadian journal of urology
  • [ISO-abbreviation] Can J Urol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
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37. Nascimento AF, Raut CP, Fletcher CD: Primary angiosarcoma of the breast: clinicopathologic analysis of 49 cases, suggesting that grade is not prognostic. Am J Surg Pathol; 2008 Dec;32(12):1896-904
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  • [Title] Primary angiosarcoma of the breast: clinicopathologic analysis of 49 cases, suggesting that grade is not prognostic.
  • Mammary angiosarcoma is a rare neoplasm, accounting for about 0.05% of all primary malignancies of the breast.
  • It is currently believed that histologic grading of mammary angiosarcomas plays an important role in prognostication.
  • Forty-nine cases of primary angiosarcoma of the breast were retrieved from our files.
  • Ten patients (24.4%) showed evidence of local recurrence within 11 to 60 months (median 36) after diagnosis.
  • Time interval between diagnosis and metastasis ranged from 2 to 144 months (median 34).
  • Eighteen patients (44%) so far have died of disease and 1 died of presumably disseminated breast carcinoma.
  • Five patients (12.2%) are alive with disease and 15 patients (36.6%) are alive with no evidence of disease.
  • Statistical analysis evaluating correlation between tumor grade and size, and rate of local recurrence, metastasis, and death owing to disease showed no significant difference among tumors of different grades.
  • In conclusion, mammary angiosarcoma is a rare disease that affects relatively younger patients.
  • This tumor seems to have an overall similar clinical course as other types of angiosarcoma arising in skin or soft tissue; it carries a moderate risk of local recurrence, and a high risk of metastasis and death.
  • In this large series, there is no correlation between histologic grade and patient outcome, more in line with angiosarcomas at other sites.
  • [MeSH-major] Breast Neoplasms / pathology. Hemangiosarcoma / pathology
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Aged. Disease-Free Survival. Female. Humans. Middle Aged. Prognosis

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  • (PMID = 18813119.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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38. Juergens KU, Hoffmeier A, Riemann B, Maintz D: Early detection of local tumour recurrence and pulmonary metastasis in cardiac angiosarcoma with PET-CT and MRI. Eur Heart J; 2007 Mar;28(6):663
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  • [Title] Early detection of local tumour recurrence and pulmonary metastasis in cardiac angiosarcoma with PET-CT and MRI.
  • [MeSH-major] Heart Neoplasms / diagnosis. Hemangiosarcoma / diagnosis. Hemangiosarcoma / secondary. Lung Neoplasms / secondary
  • [MeSH-minor] Early Diagnosis. Female. Humans. Magnetic Resonance Angiography. Middle Aged. Neoplasm Recurrence, Local / diagnosis. Positron-Emission Tomography

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  • (PMID = 17363449.001).
  • [ISSN] 0195-668X
  • [Journal-full-title] European heart journal
  • [ISO-abbreviation] Eur. Heart J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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39. Kurian KM, Tagkalakis P, Erridge SC, Ironside JW, Whittle IR: Primary intracranial angiosarcoma of the Pineal gland: an unusual cause of recurrent intraventricular haemorrhage and superficial haemosiderosis. Neuropathol Appl Neurobiol; 2006 Oct;32(5):557-61
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  • [Title] Primary intracranial angiosarcoma of the Pineal gland: an unusual cause of recurrent intraventricular haemorrhage and superficial haemosiderosis.
  • [MeSH-major] Cerebral Ventricles / pathology. Hemangiosarcoma / complications. Hemosiderosis / pathology. Intracranial Hemorrhages / etiology. Pinealoma / complications

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  • (PMID = 16972889.001).
  • [ISSN] 0305-1846
  • [Journal-full-title] Neuropathology and applied neurobiology
  • [ISO-abbreviation] Neuropathol. Appl. Neurobiol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
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40. Inaba T, Yamanaka K, Asahi K, Omoto Y, Isoda K, Hurwitz D, Kupper TS, Mizutani H: Complete remission in a patient with angiosarcoma by the combination of OK-432, rhIL-2, and radiotherapy. Eur J Dermatol; 2005 Sep-Oct;15(5):411-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Complete remission in a patient with angiosarcoma by the combination of OK-432, rhIL-2, and radiotherapy.
  • [MeSH-major] Antineoplastic Agents / administration & dosage. Head and Neck Neoplasms / drug therapy. Hemangiosarcoma / therapy. Interleukin-2 / administration & dosage. Picibanil / administration & dosage. Skin Neoplasms / therapy

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  • [CommentOn] Eur J Dermatol. 1999 Mar;9(2):118-21 [10066960.001]
  • (PMID = 16208887.001).
  • [ISSN] 1167-1122
  • [Journal-full-title] European journal of dermatology : EJD
  • [ISO-abbreviation] Eur J Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Comment; Letter
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Interleukin-2; 0 / Recombinant Proteins; 39325-01-4 / Picibanil
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41. Al Dhaybi R, Powell J, McCuaig C, Kokta V: Differentiation of vascular tumors from vascular malformations by expression of Wilms tumor 1 gene: evaluation of 126 cases. J Am Acad Dermatol; 2010 Dec;63(6):1052-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Based on the International Society for the Study of Vascular Anomalies classification of vascular anomalies, we studied the expression of WT1 in vascular tumors composed of infantile hemangioma, congenital hemangiomas (non-involuting, rapidly involuting, and not otherwise specified), pyogenic granuloma, tufted angioma, cherry angioma, Kaposi sarcoma, and angiosarcoma.
  • RESULTS: All vascular tumors and proliferations had positive WT1 cytoplasmic endothelial immunostaining whereas only 3 vascular malformations were WT1 positive.
  • LIMITATIONS: The low number of malignant vascular tumors is a limitation.
  • [MeSH-minor] Adolescent. Adult. Aged. Biopsy. Cell Division / physiology. Child. Child, Preschool. Cytoplasm / metabolism. Diagnosis, Differential. Humans. Immunohistochemistry. Infant. Infant, Newborn. Middle Aged. Young Adult


42. Kostov D, Kobakov G, Dragnev N: [Operative-technical special features of the left lobectomy in colorectal cancer liver metastases]. Khirurgiia (Sofiia); 2006;(6):8-11
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  • The indications of the liver resection are the primary and secondary malignant neoplasms of the liver, the benign liver tumors and some inflammatory diseases.
  • The indications of the operation of eight of them were solitary metastases, which had appeared after an operation on colorectal cancer and at one of them the resection was performed due to an angiosarcoma of the liver.


43. Perry B, Banyard J, McLaughlin ER, Watnick R, Sohn A, Brindley DN, Obata T, Cantley LC, Cohen C, Arbiser JL: AKT1 overexpression in endothelial cells leads to the development of cutaneous vascular malformations in vivo. Arch Dermatol; 2007 Apr;143(4):504-6
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  • [Title] AKT1 overexpression in endothelial cells leads to the development of cutaneous vascular malformations in vivo.
  • BACKGROUND: Vascular malformations are clinical disorders in which endothelial cells fail to remodel and/or undergo programmed cell death, leading to abnormal persistence of blood vessels.
  • OBSERVATIONS: We examined the effect of constitutive activation of Akt1 in murine endothelial cells (MS1 cells).
  • Overexpression of active AKT1 in MS1 cells led to the development of vascular malformations, characterized by wide endothelial lumens and minimal investment of smooth muscle surrounding the vessels.
  • The histologic features of these vascular malformations is distinct from ras-transformed MS1 cells (angiosarcoma) and suggest that differing signal abnormalities give rise to human vascular malformations vs malignant vascular tumors.

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  • (PMID = 17438183.001).
  • [ISSN] 0003-987X
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] ENG
  • [Grant] United States / NIGMS NIH HHS / GM / R01 GM041890; United States / NIAMS NIH HHS / AR / P30 AR42687; United States / NIAMS NIH HHS / AR / R01 AR47901
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.11.1 / AKT1 protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt
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44. Gambini D, Visintin R, Locatelli E, Galassi B, Bareggi C, Runza L, Onida F, Tomirotti M: Paclitaxel-dependent prolonged and persistent complete remission four years from first recurrence of secondary breast angiosarcoma. Tumori; 2009 Nov-Dec;95(6):828-31
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  • [Title] Paclitaxel-dependent prolonged and persistent complete remission four years from first recurrence of secondary breast angiosarcoma.
  • Among angiosarcomas, radiation-induced breast sarcomas (RIBS) represent a well-known entity generally characterized by a poor outcome, especially in patients with advanced disease.
  • Treatments with demonstrated activity against sarcomas include ifosfamide-based regimens and, more recently, taxane derivatives.
  • We report a case of a patient having a secondary breast angiosarcoma recurring early after surgery, who achieved complete remission following treatment with weekly paclitaxel.
  • [MeSH-major] Angiogenesis Inhibitors / therapeutic use. Antineoplastic Agents, Phytogenic / therapeutic use. Breast Neoplasms / drug therapy. Hemangiosarcoma / drug therapy. Mastectomy, Segmental. Neoplasm Recurrence, Local / drug therapy. Paclitaxel / therapeutic use

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  • (PMID = 20210253.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Antineoplastic Agents, Phytogenic; P88XT4IS4D / Paclitaxel
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45. Papadimitriou VD, Stamatiou KN, Takos DM, Adamopoulos VM, Heretis IE, Sofras FA: Angiosarcoma of kidney: a case report and review of literature. Urol J; 2009;6(3):223-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma of kidney: a case report and review of literature.
  • [MeSH-major] Hemangiosarcoma / etiology. Kidney Neoplasms / etiology. Multicystic Dysplastic Kidney / complications

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  • (PMID = 19711281.001).
  • [ISSN] 1735-546X
  • [Journal-full-title] Urology journal
  • [ISO-abbreviation] Urol J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Iran
  • [Number-of-references] 18
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46. Grégoire F, Mousset B, Hanrez D, Cassart D, Desmecht D, Linden A: Cavernous haemangiosarcoma in a free-living red deer (Cervus elaphus). Vet Rec; 2008 May 24;162(21):692-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cavernous haemangiosarcoma in a free-living red deer (Cervus elaphus).
  • [MeSH-major] Bone Neoplasms / veterinary. Deer. Hemangiosarcoma / veterinary. Lung Neoplasms / veterinary. Ribs

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  • (PMID = 18503071.001).
  • [ISSN] 0042-4900
  • [Journal-full-title] The Veterinary record
  • [ISO-abbreviation] Vet. Rec.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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47. Berretta M, Rupolo M, Buonadonna A, Canzonieri V, Brollo A, Morra A, Berretta S, Bearz A, Tirelli U, Frustaci S: Metastatic angiosarcoma of the kidney: a case report with treatment approach and review of the literature. J Chemother; 2006 Apr;18(2):221-4
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  • [Title] Metastatic angiosarcoma of the kidney: a case report with treatment approach and review of the literature.
  • Angiosarcomas are rare soft tissue malignancies.
  • Typically they originate from the skin of the scalp or face, whereas visceral sarcomas are very rare.
  • We report the case of a 67-year-old man affected by a large angiosarcoma of the kidney.
  • Palliative chemotherapy, based on anthracycline and ifosfamide, which are normally used to treat all other high-grade spindle cell sarcomas, was totally inactive.
  • Antiangiogenetic agents are of interest for this disease due to the peculiar origin of the cells of these sarcomas.
  • [MeSH-major] Hemangiosarcoma / drug therapy. Hemangiosarcoma / surgery. Kidney Neoplasms / drug therapy. Kidney Neoplasms / surgery

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  • (PMID = 16736893.001).
  • [ISSN] 1120-009X
  • [Journal-full-title] Journal of chemotherapy (Florence, Italy)
  • [ISO-abbreviation] J Chemother
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Anthracyclines; UM20QQM95Y / Ifosfamide
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48. Gupta A, Saifuddin A, Briggs TW, Flanagan AM: Subperiosteal hemangioendothelioma of the femur. Skeletal Radiol; 2006 Oct;35(10):793-6
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  • [Title] Subperiosteal hemangioendothelioma of the femur.
  • Primary neoplastic vascular lesions of bone are rare, and include haemangiomas, haemangioendothelioma, epithelioid haemangioendothelioma and angiosarcoma.
  • We report a case of haemangioendothelioma localised to the subperiosteum of the femur, a site not previously described for this lesion.
  • [MeSH-major] Femoral Neoplasms / diagnosis. Hemangioendothelioma / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male. Tomography, X-Ray Computed

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  • (PMID = 16421750.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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49. Oe A, Habu D, Kawabe J, Torii K, Kawamura E, Kotani J, Hayashi T, Sakaguchi H, Shiomi S: A case of diffuse hepatic angiosarcoma diagnosed by FDG-PET. Ann Nucl Med; 2005 Sep;19(6):519-21
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  • [Title] A case of diffuse hepatic angiosarcoma diagnosed by FDG-PET.
  • She was diagnosed by histopathological examination as having hepatic angiosarcoma causing veno-occlusive disease (VOD).
  • This is the first report of hepatic angiosarcoma with FDG-PET.
  • [MeSH-major] Fluorodeoxyglucose F18. Hemangiosarcoma / complications. Hemangiosarcoma / radionuclide imaging. Hepatic Veno-Occlusive Disease / etiology. Hepatic Veno-Occlusive Disease / radionuclide imaging. Liver Neoplasms / complications. Liver Neoplasms / radionuclide imaging

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  • (PMID = 16248391.001).
  • [ISSN] 0914-7187
  • [Journal-full-title] Annals of nuclear medicine
  • [ISO-abbreviation] Ann Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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50. Miyake M, Tateishi U, Maeda T, Arai Y, Hasegawa T, Sugimura K: MR features of angiosarcoma in a patient with Maffucci's syndrome. Radiat Med; 2005 Nov;23(7):508-12
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  • [Title] MR features of angiosarcoma in a patient with Maffucci's syndrome.
  • Maffucci's syndrome is a rare sporadic congenital disorder associated with multiple enchondromas and soft tissue hemangiomas.
  • These bone and soft tissue tumors have the potential of malignant transformation to various histologic types: chondrosarcoma, osteosarcoma, fibrosarcoma, and angiosarcoma.
  • We report a rare case of Maffucci's syndrome with soft tissue angiosarcoma of the leg to illustrate MRI findings with pathologic correlations.
  • [MeSH-major] Hemangiosarcoma / diagnosis. Magnetic Resonance Imaging / methods. Soft Tissue Neoplasms / diagnosis

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  • (PMID = 16485543.001).
  • [ISSN] 0288-2043
  • [Journal-full-title] Radiation medicine
  • [ISO-abbreviation] Radiat Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Contrast Media; K2I13DR72L / Gadolinium DTPA
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51. Manner J, Radlwimmer B, Hohenberger P, Mössinger K, Küffer S, Sauer C, Belharazem D, Zettl A, Coindre JM, Hallermann C, Hartmann JT, Katenkamp D, Katenkamp K, Schöffski P, Sciot R, Wozniak A, Lichter P, Marx A, Ströbel P: MYC high level gene amplification is a distinctive feature of angiosarcomas after irradiation or chronic lymphedema. Am J Pathol; 2010 Jan;176(1):34-9
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  • [Title] MYC high level gene amplification is a distinctive feature of angiosarcomas after irradiation or chronic lymphedema.
  • Angiosarcomas (AS) are rare vascular malignancies that arise either de novo as primary tumors or secondary to irradiation or chronic lymphedema.
  • The cytogenetics of angiosarcomas are poorly characterized.
  • Fluorescence in situ hybridization analysis in 28 primary and 33 secondary angiosarcomas (31 tumors secondary to irradiation, 2 tumors secondary to chronic lymphedema) confirmed high level amplification of MYC on chromosome 8q24.21 as a recurrent genetic alteration found exclusively in 55% of AS secondary to irradiation or chronic lymphedema, but not in primary AS.
  • This finding may have implications both for the diagnosis and treatment of these tumors.
  • [MeSH-major] Gene Amplification / genetics. Hemangiosarcoma / etiology. Hemangiosarcoma / genetics. Lymphedema / complications. Proto-Oncogene Proteins c-myc / genetics. Radiotherapy / adverse effects
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Chromosome Deletion. Chronic Disease. DNA Copy Number Variations / genetics. Female. Genetic Loci / genetics. Homozygote. Humans. In Situ Hybridization, Fluorescence. Male. Middle Aged

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  • (PMID = 20008140.001).
  • [ISSN] 1525-2191
  • [Journal-full-title] The American journal of pathology
  • [ISO-abbreviation] Am. J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Proto-Oncogene Proteins c-myc
  • [Other-IDs] NLM/ PMC2797867
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52. Bioulac-Sage P, Laumonier H, Laurent C, Blanc JF, Balabaud C: Benign and malignant vascular tumors of the liver in adults. Semin Liver Dis; 2008 Aug;28(3):302-14
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  • [Title] Benign and malignant vascular tumors of the liver in adults.
  • Vascular tumors of the liver in adult patients include cavernous hemangioma, a common benign tumor; epithelioid hemangioendothelioma, a rare, usually low-grade malignant tumor; and angiosarcoma, a rare and very aggressive tumor.
  • A definitive diagnosis of epithelioid hemangioendothelioma and angiosarcoma requires histopathologic examination.
  • Liver transplantation at an early stage has greatly improved the prognosis of epithelioid hemangioendothelioma.
  • The prognosis of angiosarcoma remains dismal.
  • [MeSH-minor] Adult. Hemangioendothelioma, Epithelioid / pathology. Hemangioendothelioma, Epithelioid / therapy. Hemangioma, Cavernous / pathology. Hemangioma, Cavernous / therapy. Hemangiosarcoma / pathology. Hemangiosarcoma / therapy. Hepatic Stellate Cells / pathology. Humans. Sarcoma, Kaposi / pathology. Sarcoma, Kaposi / therapy. Treatment Outcome

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  • (PMID = 18814083.001).
  • [ISSN] 0272-8087
  • [Journal-full-title] Seminars in liver disease
  • [ISO-abbreviation] Semin. Liver Dis.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 45
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53. Christensen N, Canfield P, Martin P, Krockenberger M, Spielman D, Bosward K: Cytopathological and histopathological diagnosis of canine splenic disorders. Aust Vet J; 2009 May;87(5):175-81
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  • [Title] Cytopathological and histopathological diagnosis of canine splenic disorders.
  • OBJECTIVES: To determine (1) the common types of canine splenic disorders, and the breeds affected, that are diagnosed by cytopathological and histopathological examination in Sydney, Australia and (2) the accuracy of cytopathological examination compared with histopathological examination for the diagnosis of canine splenic disorders.
  • RESULTS: The most common cytopathological diagnoses were benign disorders of growth, vascular disturbances and necrosis (29%), followed by no abnormalities detectable (28%), malignant neoplasms (20%), equivocal diagnoses (20%) and inflammatory disorders (3%).
  • The most common histopathological diagnoses were benign disorders of growth, vascular disturbances and necrosis (49%), followed by malignant neoplasms (43%) and inflammatory disorders (8%).
  • German Shepherd Dogs were the most common breed diagnosed histopathologically with haemangiosarcoma.
  • Although cytopathological and histopathological splenic examinations are complementary for diagnosis, this study has shown a high correlation for complete and partial agreement between the two.

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  • (PMID = 19382924.001).
  • [ISSN] 0005-0423
  • [Journal-full-title] Australian veterinary journal
  • [ISO-abbreviation] Aust. Vet. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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54. Liu ZH, Lee ST, Jung SM, Tu PH: Primary spinal angiosarcoma. J Clin Neurosci; 2010 Mar;17(3):387-9
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  • [Title] Primary spinal angiosarcoma.
  • Primary angiosarcoma of the spine is rare.
  • To our knowledge, primary angiosarcoma in the posterior element of the spine has not been reported previously.
  • [MeSH-major] Hemangiosarcoma. Spinal Neoplasms

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  • [Copyright] Copyright 2009 Elsevier Ltd. All rights reserved.
  • (PMID = 20074966.001).
  • [ISSN] 1532-2653
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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55. Bonaccorsi-Riani E, Lerut JP: Liver transplantation and vascular tumours. Transpl Int; 2010 Jul;23(7):686-91
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  • Hepatic epithelioid haemangioendothelioma has currently become a good indication for LT with 5- and 10-year post-LT patient survival rates of 83% and 74% respectively and 5- and 10-year recurrence-free survival rates of 82% and 64% respectively.
  • In contrast, the results of LT for haemangiosarcoma (HAS) are disastrous with an universal tumour recurrence within 6 months and no single patient survival after 2 years.
  • The value of LT in the treatment of infantile haemangioendothelioma is more difficult to evaluate because of the very reduced number of reported cases and because of the often difficult differential diagnosis with angiosarcoma.
  • [MeSH-major] Hemangioendothelioma, Epithelioid / surgery. Hemangiosarcoma / surgery. Liver Neoplasms / surgery. Liver Transplantation. Vascular Neoplasms / surgery

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  • (PMID = 20492619.001).
  • [ISSN] 1432-2277
  • [Journal-full-title] Transplant international : official journal of the European Society for Organ Transplantation
  • [ISO-abbreviation] Transpl. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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56. Meyers RL: Tumors of the liver in children. Surg Oncol; 2007 Nov;16(3):195-203
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  • In this review we examine the diagnosis and treatment of pediatric liver tumors- both malignant and benign.
  • The two most common malignant tumors are hepatoblastoma and hepatocellular carcinoma.
  • Other malignant liver tumors are quite rare and include biliary rhabdomyosarcoma, angiosarcoma, rhabdoid tumor, and undifferentiated sarcoma.

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  • (PMID = 17714939.001).
  • [ISSN] 0960-7404
  • [Journal-full-title] Surgical oncology
  • [ISO-abbreviation] Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 69
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57. Lim RF, Goei R: Best cases from the AFIP: angiosarcoma of the breast. Radiographics; 2007 Oct;27 Suppl 1:S125-30
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  • [Title] Best cases from the AFIP: angiosarcoma of the breast.
  • [MeSH-major] Breast Neoplasms / pathology. Hemangiosarcoma / pathology

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  • (PMID = 18180222.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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58. Poellinger A, Landt S, Diekmann F, Guski H, Bick U: Rapid growth of an exophytic angiosarcoma of the breast. Breast J; 2006 Jan-Feb;12(1):80-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Rapid growth of an exophytic angiosarcoma of the breast.
  • [MeSH-major] Breast Neoplasms / diagnosis. Hemangiosarcoma / diagnosis
  • [MeSH-minor] Aged. Aged, 80 and over. Carcinoma, Ductal, Breast / diagnosis. Carcinoma, Ductal, Breast / pathology. Carcinoma, Ductal, Breast / radiography. Carcinoma, Ductal, Breast / surgery. Diagnosis, Differential. Female. Humans. Mammography. Mastectomy

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  • (PMID = 16409594.001).
  • [ISSN] 1075-122X
  • [Journal-full-title] The breast journal
  • [ISO-abbreviation] Breast J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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59. Sorenmo K, Samluk M, Clifford C, Baez J, Barrett JS, Poppenga R, Overley B, Skorupski K, Oberthaler K, Van Winkle T, Seiler G, Shofer F: Clinical and pharmacokinetic characteristics of intracavitary administration of pegylated liposomal encapsulated doxorubicin in dogs with splenic hemangiosarcoma. J Vet Intern Med; 2007 Nov-Dec;21(6):1347-54
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  • [Title] Clinical and pharmacokinetic characteristics of intracavitary administration of pegylated liposomal encapsulated doxorubicin in dogs with splenic hemangiosarcoma.
  • BACKGROUND: Canine splenic hemangiosarcoma (HSA) is a fatal malignancy, and most affected dogs die within a few months of diagnosis.
  • The abdomen is also the main site of disease recurrence.
  • After staging of disease status and splenectomy, pegylated liposomal encapsulated doxorubicin was administered intraperitoneally (1 mg/kg body weight) every 3 weeks for 4 cycles.

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  • (PMID = 18196746.001).
  • [ISSN] 0891-6640
  • [Journal-full-title] Journal of veterinary internal medicine
  • [ISO-abbreviation] J. Vet. Intern. Med.
  • [Language] ENG
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / liposomal doxorubicin; 30IQX730WE / Polyethylene Glycols; 80168379AG / Doxorubicin
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60. Umscheid TW, Rouhani G, Morlang T, Lorey T, Klein PJ, Ziegler P, Stelter WJ: Hemangiosarcoma after endovascular aortic aneurysm repair. J Endovasc Ther; 2007 Feb;14(1):101-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hemangiosarcoma after endovascular aortic aneurysm repair.
  • PURPOSE: To report a rare case of hemangiosarcoma after endovascular aneurysm repair (EVAR).
  • CONCLUSION: Morphological changes of the aneurysm wall seen on computed tomographic scans of EVAR patients may not be incidental or signs of infection; rather, a malignant tumor of the aorta or lymphatic disease, although rare, have to be taken into consideration as well.
  • [MeSH-major] Aortic Aneurysm, Abdominal / surgery. Blood Vessel Prosthesis Implantation / adverse effects. Hemangiosarcoma / etiology. Stents

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  • (PMID = 17291154.001).
  • [ISSN] 1526-6028
  • [Journal-full-title] Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists
  • [ISO-abbreviation] J. Endovasc. Ther.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Polyethylene Terephthalates
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61. Choi KS, Chun HJ, Yi HJ, Kim JT: Intracranial invasion from recurrent angiosarcoma of the scalp. J Korean Neurosurg Soc; 2008 Apr;43(4):201-4
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  • [Title] Intracranial invasion from recurrent angiosarcoma of the scalp.
  • Angiosarcoma of the brain, either primary or metastatic is extremely rare.
  • Moreover, angiosarcoma metastasizing to the brain is also highly unlike to occur comparing with metastases to the other organs.
  • A 67-year-old man with past surgical history of a scalp angiosarcoma underwent surgical resection of intracranial invasion.

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  • [Cites] Neurosurgery. 1996 Mar;38(3):583-5; discussion 585-6 [8837814.001]
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  • (PMID = 19096645.001).
  • [ISSN] 2005-3711
  • [Journal-full-title] Journal of Korean Neurosurgical Society
  • [ISO-abbreviation] J Korean Neurosurg Soc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2588263
  • [Keywords] NOTNLM ; Brain neoplasm / Metastasis / Scalp Angiosarcoma / Scalp flap
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62. Berry MF, Williams M, Welsby I, Lin S: Cardiac angiosarcoma presenting with right coronary artery pseudoaneurysm. J Cardiothorac Vasc Anesth; 2010 Aug;24(4):633-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cardiac angiosarcoma presenting with right coronary artery pseudoaneurysm.
  • [MeSH-major] Aneurysm, False / diagnosis. Coronary Vessels / pathology. Heart Neoplasms / diagnosis. Hemangiosarcoma / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male

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  • (PMID = 19525126.001).
  • [ISSN] 1532-8422
  • [Journal-full-title] Journal of cardiothoracic and vascular anesthesia
  • [ISO-abbreviation] J. Cardiothorac. Vasc. Anesth.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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63. Sluzevich JC, Gloster HJ, Mutasim DF: A case of regressing central facial cutaneous angiosarcoma. J Am Acad Dermatol; 2008 May;58(5 Suppl 1):S113-5
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  • [Title] A case of regressing central facial cutaneous angiosarcoma.
  • [MeSH-major] Eyelid Neoplasms / pathology. Hemangiosarcoma / pathology. Skin Neoplasms / pathology

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  • (PMID = 18489041.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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64. van Geel AN, den Bakker MA: Bilateral angiosarcoma of the breast in a fourteen-year-old child. Rare Tumors; 2009;1(2):e38
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  • [Title] Bilateral angiosarcoma of the breast in a fourteen-year-old child.
  • Malignant vascular tumors are rare and angiosarcomas of the breast in patients under 21 years of age are exceedingly uncommon.
  • In this report an angiosarcoma in the breast of a 14-year-old girl is described.
  • She died nine months after mastectomy with recurrent disease in the bones and the contralateral breast.
  • The etiology of most primary angiosarcomas is unknown.
  • Secondary angiosarcomas can develop after radiotherapy and chronic lymphedema.
  • The histology of this angiosarcoma is illustrated.

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  • (PMID = 21139917.001).
  • [ISSN] 2036-3613
  • [Journal-full-title] Rare tumors
  • [ISO-abbreviation] Rare Tumors
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2994455
  • [Keywords] NOTNLM ; angiosarcoma / breast. / infancy
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65. Holloway CL, Turner AR, Dundas GS: Cutaneous angiosarcoma of the scalp: a case report of sustained complete response following liposomal Doxorubicin and radiation therapy. Sarcoma; 2005;9(1-2):29-31
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  • [Title] Cutaneous angiosarcoma of the scalp: a case report of sustained complete response following liposomal Doxorubicin and radiation therapy.
  • Cutaneous angiosarcomas of the head and neck are aggressive cancers with a mean overall survival of 30 months.
  • We add to the literature a case report of a 65-year-old man with a large, >10 cm, unresectable, angiosarcoma of the scalp who was treated with two cycles of liposomal doxorubicin (Caelyx(R)) followed by electron beam radiation therapy (30 Gy in 10 fractions over 2 weeks) who has sustained a complete response with a 4-year follow-up.

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  • (PMID = 18521414.001).
  • [ISSN] 1357-714X
  • [Journal-full-title] Sarcoma
  • [ISO-abbreviation] Sarcoma
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC2395620
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66. Jin M, Matsumoto S, Dewa Y, Nishimura J, Saekusa Y, Hasumi K, Mitsumori K: Extremely weak tumor-promoting effect of troglitazone on splenic hemangiosarcomas in rasH2 mice induced by urethane. Arch Toxicol; 2008 Oct;82(10):771-7
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  • [Title] Extremely weak tumor-promoting effect of troglitazone on splenic hemangiosarcomas in rasH2 mice induced by urethane.
  • To examine the tumor-promoting effect of troglitazone (TRG), a novel thiazolidinedione insulin-sensitizing agent, on splenic hemangiosarcomas in rasH2 mice, histopathological and molecular analyses were performed in the spleen of female rasH2 mice fed a diet containing 6,000 or 0 ppm TRG for 16 weeks after 1,000 or 0 mg/kg urethane (UR) initiation.
  • Histopathologically, splenic hemangiosarcomas were observed in the UR-alone and UR + TRG groups, but there was no significant difference in the incidence of splenic hemangiosarcomas between the UR-alone and UR+TRG groups.
  • These results suggest that the vascular tumor-promoting activity of TRG in rasH2 mice is extremely low in the present experimental condition and a part of the gene related to angiogenesis probably contributes to the promotion of splenic hemangiosarcomas in rasH2 mice given TRG.
  • [MeSH-major] Carcinogens / toxicity. Chromans / toxicity. Hemangiosarcoma / chemically induced. Neoplasms, Experimental / chemically induced. Proto-Oncogene Proteins p21(ras) / genetics. Splenic Neoplasms / chemically induced. Thiazolidinediones / toxicity

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  • (PMID = 18465119.001).
  • [ISSN] 1432-0738
  • [Journal-full-title] Archives of toxicology
  • [ISO-abbreviation] Arch. Toxicol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Angiogenic Proteins; 0 / Carcinogens; 0 / Chromans; 0 / Thiazolidinediones; 3IN71E75Z5 / Urethane; EC 3.6.5.2 / HRAS protein, human; EC 3.6.5.2 / Proto-Oncogene Proteins p21(ras); I66ZZ0ZN0E / troglitazone
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67. Dunlap JB, Magenis RE, Davis C, Himoe E, Mansoor A: Cytogenetic analysis of a primary bone angiosarcoma. Cancer Genet Cytogenet; 2009 Oct;194(1):1-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytogenetic analysis of a primary bone angiosarcoma.
  • Primary bone angiosarcomas are rare and aggressive vascular malignancies with a high mortality rate.
  • To our knowledge, there are no reported cytogenetic abnormalities in primary bone angiosarcomas, although several have been reported in soft tissue angiosarcomas.
  • We report a case of primary bone angiosarcoma, arising in the tibia of a 79-year-old woman, with a unique clonal chromosomal rearrangement: t(1;14)(p21;q24), that has not been reported in either soft tissue or primary bone angiosarcoma.
  • [MeSH-major] Bone Neoplasms / genetics. Hemangiosarcoma / genetics. Translocation, Genetic

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  • (PMID = 19737647.001).
  • [ISSN] 1873-4456
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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68. Korkolis DP, Papaevangelou M, Koulaxouzidis G, Zirganos N, Psichogiou H, Vassilopoulos PP: Intravascular papillary endothelial hyperplasia (Masson's hemangioma) presenting as a soft-tissue sarcoma. Anticancer Res; 2005 Mar-Apr;25(2B):1409-12
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  • [Title] Intravascular papillary endothelial hyperplasia (Masson's hemangioma) presenting as a soft-tissue sarcoma.
  • Intravascular papillary endothelial hyperplasia (Masson's hemangioma) is an unusual benign, non-neoplastic, vascular lesion characterized histologically by papillary fronds lined by proliferating endothelium.
  • The main significance of intravascular papillary endothelial hyperplasia is its clinical and histological resemblance to soft-tissue sarcoma and possible misinterpretation as such.
  • A case of intravascular papillary endothelial hyperplasia clinically diagnosed and treated as a low-grade angiosarcoma, in a 60-year-old man, presenting with a mass in the left thigh, is reported.
  • [MeSH-major] Hemangioendothelioma / diagnosis. Thigh
  • [MeSH-minor] Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Sarcoma / diagnosis. Soft Tissue Neoplasms / diagnosis


69. Heo SH, Jeong YY, Shin SS, Chung TW, Kang HK: Solitary small hepatic angiosarcoma: initial and follow-up imaging findings. Korean J Radiol; 2007 Mar-Apr;8(2):180-3
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  • [Title] Solitary small hepatic angiosarcoma: initial and follow-up imaging findings.
  • We report an uncommon case of solitary, small hepatic angiosarcoma that was initially considered as a hemangioma.
  • We present the imaging findings, with an emphasis on the initial and follow-up CT and MR findings, as well as report on the more suggestive findings of angiosarcoma than those of a hemangioma.
  • [MeSH-major] Hemangiosarcoma / diagnosis. Liver Neoplasms / diagnosis
  • [MeSH-minor] Contrast Media. Diagnosis, Differential. Gadolinium DTPA. Hemangioma / diagnosis. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Tomography, X-Ray Computed

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  • [Cites] AJR Am J Roentgenol. 2000 Jul;175(1):165-70 [10882268.001]
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  • (PMID = 17420638.001).
  • [ISSN] 1229-6929
  • [Journal-full-title] Korean journal of radiology
  • [ISO-abbreviation] Korean J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Contrast Media; K2I13DR72L / Gadolinium DTPA
  • [Other-IDs] NLM/ PMC2626776
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70. Welsh SJ, Khan S: Radiological localizing techniques in adrenal tumors. Minerva Endocrinol; 2009 Jun;34(2):161-9
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  • Unfortunately, there may be significant overlap between the imaging appearances of benign lesions such as lipid-poor adenomas and malignant lesions, particularly metastases and small adrenal carcinomas.
  • This review highlights recent advances in radiological imaging of adrenal lesions and we discuss the relative merits of CT and magnetic resonance imaging to aid the identification of benign and malignant adrenal lesions and their roles, in combination with biochemical and clinical data, in recognizing common pathologies such as adrenal adenoma, phaeochromocytoma, carcinoma and metastases.
  • We also discuss the radiological characteristics of rarer adrenal lesions including lymphoma, neuroblastic tumours (neuroblastoma, ganglioneuroblastoma, and ganglioneuroma), lipomatous tumours (myelolipoma, angiolipoma, teratoma, lipoma and liposarcoma), in addition to hemangioma, hemangiosarcoma and leiomyosarcoma.
  • [MeSH-minor] Adrenal Cortex Neoplasms / radiography. Adrenocortical Adenoma / radiography. Adrenocortical Carcinoma / radiography. Diagnosis, Differential. Ganglioneuroblastoma / radiography. Ganglioneuroma / radiography. Humans. Lymphoma / radiography. Magnetic Resonance Imaging. Neoplasm Metastasis. Neoplasms, Adipose Tissue / radiography. Neoplasms, Vascular Tissue / radiography. Neuroblastoma / radiography. Pheochromocytoma / radiography. Predictive Value of Tests. Sensitivity and Specificity. Teratoma / radiography

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  • (PMID = 19471240.001).
  • [ISSN] 0391-1977
  • [Journal-full-title] Minerva endocrinologica
  • [ISO-abbreviation] Minerva Endocrinol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 42
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71. Lincoln DT, Singal PK, Al-Banaw A: Growth hormone in vascular pathology: neovascularization and expression of receptors is associated with cellular proliferation. Anticancer Res; 2007 Nov-Dec;27(6B):4201-18
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  • The well-differentiated tumours consist of irregular anastomosing, blood-filled vascular channels that are lined by variably atypical endothelial cells.
  • Several growth factors, including basic fibroblast growth factor, transforming growth factors and vascular endothelial growth factor, play a role in tumour angiogenesis.
  • Growth hormone (GH) is mitogenic for a variety of vascular tissue cells, including smooth muscle cells, fibroblasts and endothelial cells and exerts its regulatory functions in controlling metabolism, balanced growth and differentiated cell expression by acting on specific membrane-bound receptors, which trigger a phosphorylation cascade resulting in the modulation of numerous signalling pathways and of gene expression.
  • A total of 64 benign and malignant vascular tumours were obtained from different human organ sites, including the chest wall, skin, axillary contents, duodenum, female breast, abdomen, stomach, colon, lymph node, bladder, body flank and neck regions.
  • The tumours were of the following pathological entities: Haemangioma (n = 12); haemangioendothelioma (n = 10); Castleman's disease (n = 3), haemangiopericytoma (n = 4); angiosarcoma, (n = 11), Kaposi's sarcoma with focal infiltration by lymphoma, HIV +ve (n = 7), Kaposi's sarcoma (n = 17).
  • The endothelial cell marker CD-31 was used to establish endothelial cell characteristics and microvascular density.
  • Results show that, compared to their normal tissue counterparts, nuclear and cytoplasmic expression of GHR consistently result in strong receptor immunoreactivity in the highly malignant angiosarcomas and Kaposi's sarcomas and was localized in the cell membranes and cytoplasm, but strong nuclear immunoreactivity was also identified.
  • Malignant cells, which are highly expressive of the receptor, have a greater proliferation rate and thereby also higher survival rate compared to tumours expressing lower or minimal receptor level.
  • The presence of GHR in endothelial cells of vascular neoplasm indicates that they are target cells and GH is of importance in the proliferation of vascular tumour angiogenesis.

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  • [ErratumIn] Anticancer Res. 2008 Mar-Apr;28(2b):1439
  • (PMID = 18225592.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Receptors, Somatotropin; 9002-72-6 / Growth Hormone
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72. Peramiquel L, Barnadas MA, Sancho J, Curell R, Alonso MC, Fuentes MJ, Pernas S, Gómez A, Alomar A: [Angiosarcoma in an irradiated breast: a case description]. Actas Dermosifiliogr; 2005 Nov;96(9):602-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Angiosarcoma in an irradiated breast: a case description].
  • [Transliterated title] Angiosarcoma en mama irradiada: descripción de un caso.
  • Post-radiotherapy cutaneous angiosarcomas have been described in different locations, including the breast.
  • We present a case of cutaneous angiosarcoma of the breast, diagnosed 6 years after a carcinoma of the breast had been treated with radiation.
  • Considering the patient's symptoms, history and the changes observed via mammography, it was decided to completely excise the lesion followed by a simple mastectomy, with the diagnosis of angiosarcoma being confirmed.
  • The patient was later treated with paclitaxel, and the disease was apparently controlled.
  • Despite this fact, two years and one month later, the angiosarcoma recurred on the internal area of the mastectomy scar.
  • This complication usually appears 5-10 years after treatment with radiotherapy, so angiosarcoma should be ruled out if any angiomatous lesions later appear on skin that had been irradiated.
  • [MeSH-major] Breast Neoplasms / etiology. Breast Neoplasms / radiotherapy. Carcinoma, Ductal, Breast / radiotherapy. Hemangiosarcoma / etiology. Neoplasms, Radiation-Induced / etiology. Skin Neoplasms / etiology

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  • (PMID = 16476306.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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73. Rodríguez-Bujaldón A, Vázquez-Bayo MC, Galán-Gutiérrez M, Jiménez-Puya R, Vélez García-Nieto A, Moreno-Giménez JC, Vidal-Jiménez A, Barroso-Casamitjana E: [Angiosarcoma in chronic lymphedema]. Actas Dermosifiliogr; 2006 Oct;97(8):525-8
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  • [Title] [Angiosarcoma in chronic lymphedema].
  • [Transliterated title] Angiosarcoma sobre linfedema crónico.
  • Angiosarcoma that develops on a limb with chronic lymphedema is called Stewart-Treves syndrome.
  • The first corresponds to a typical syndrome of Stewart-Treves in an 83-year-old woman who was diagnosed of angiosarcoma in a chronic lymphedema territory secondary to mastectomy and radiotherapy due to breast cancer.
  • The second case is much rarer, since it is a case of diffuse angiosarcoma of the leg in a 42-year-old man with a history of lymphedema.
  • [MeSH-major] Hemangiosarcoma / etiology. Lymphedema / complications
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antibiotics, Antineoplastic / administration & dosage. Antibiotics, Antineoplastic / therapeutic use. Antineoplastic Agents, Alkylating / administration & dosage. Antineoplastic Agents, Alkylating / therapeutic use. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Arm. Doxorubicin / administration & dosage. Doxorubicin / therapeutic use. Female. Humans. Ifosfamide / administration & dosage. Ifosfamide / therapeutic use. Immunohistochemistry. Leg. Male. Skin / pathology. Skin Neoplasms / diagnosis. Skin Neoplasms / drug therapy. Skin Neoplasms / etiology. Skin Neoplasms / pathology. Skin Neoplasms / radiotherapy. Treatment Outcome

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  • (PMID = 17067532.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Antineoplastic Agents, Alkylating; 80168379AG / Doxorubicin; UM20QQM95Y / Ifosfamide
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74. Lee SW, Song CY, Gi YH, Kang SB, Kim YS, Nam SW, Lee DS, Kim JO: Hepatic angiosarcoma manifested as recurrent hemoperitoneum. World J Gastroenterol; 2008 May 14;14(18):2935-8
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  • [Title] Hepatic angiosarcoma manifested as recurrent hemoperitoneum.
  • Angiosarcoma is a rare tumor that account for less than 1% of all sarcomas.
  • Although hepatic angiosarcoma usually presents with unspecific symptoms, it rapidly progresses and has a high mortality.
  • We report a rare case of primary hepatic angiosarcoma manifested as recurrent hemoperitoneum.
  • [MeSH-major] Hemangiosarcoma / complications. Hemoperitoneum / diagnosis. Hemoperitoneum / etiology. Liver Neoplasms / complications
  • [MeSH-minor] Aged. Disease Progression. Female. Humans. Recurrence

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  • (PMID = 18473427.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2710744
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75. Deetjen AG, Conradi G, Möllmann S, Hamm CW, Dill T: Cardiac angiosarcoma diagnosed and characterized by cardiac magnetic resonance imaging. Cardiol Rev; 2006 Mar-Apr;14(2):101-3
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  • [Title] Cardiac angiosarcoma diagnosed and characterized by cardiac magnetic resonance imaging.
  • New imaging methods like cardiac magnetic resonance imaging (MRI) play an important role in the early diagnosis and differentiation of cardiac masses.
  • By presenting the case of a 63-year-old woman with an angiosarcoma of the right atrium and its characteristic findings on cardiac MRI, the role of this new imaging method is emphasized.
  • [MeSH-major] Heart Neoplasms / diagnosis. Hemangiosarcoma / diagnosis. Magnetic Resonance Imaging, Cine / methods

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  • (PMID = 16493248.001).
  • [ISSN] 1061-5377
  • [Journal-full-title] Cardiology in review
  • [ISO-abbreviation] Cardiol Rev
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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76. Kaddu S, Wolf I, Horn M, Kerl H: Epithelioid sarcoma with angiomatoid features: report of an unusual case arising in an elderly patient within a burn scar. J Cutan Pathol; 2008 Mar;35(3):324-8
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  • [Title] Epithelioid sarcoma with angiomatoid features: report of an unusual case arising in an elderly patient within a burn scar.
  • Epithelioid sarcoma (ES) is a rare, aggressive soft tissue tumor with a characteristic predilection for adolescents and young adults, and a tendency to occur on distal extremities.
  • The overall histopathologic features were consistent with a diagnosis of ES.
  • In this uncommon setting, this tumor should be especially distinguished from epithelioid hemangioendothelioma and epithelioid angiosarcoma.
  • [MeSH-major] Angiomatosis / pathology. Burns / pathology. Cicatrix / pathology. Sarcoma / pathology. Soft Tissue Neoplasms / pathology


77. Maeda T, Tateishi U, Hasegawa T, Ojima H, Arai Y, Sugimura K: Primary hepatic angiosarcoma on coregistered FDG PET and CT images. AJR Am J Roentgenol; 2007 Jun;188(6):1615-7
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  • [Title] Primary hepatic angiosarcoma on coregistered FDG PET and CT images.
  • [MeSH-major] Fluorodeoxyglucose F18. Hemangiosarcoma / radiography. Liver Neoplasms / radiography. Positron-Emission Tomography / methods. Subtraction Technique. Tomography, X-Ray Computed / methods

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  • (PMID = 17515384.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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78. Chapas AM, Askarian F, Demierre MF, Stefanato CM: Well-differentiated angiosarcoma of the scalp: an unusual clinical presentation. J Am Acad Dermatol; 2005 Feb;52(2 Suppl 1):58-9
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  • [Title] Well-differentiated angiosarcoma of the scalp: an unusual clinical presentation.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Hemangiosarcoma / pathology. Scalp / pathology. Skin Neoplasms / pathology

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  • (PMID = 15692518.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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79. Ettl T, Kleinheinz J, Mehrotra R, Schwarz S, Reichert TE, Driemel O: Infraorbital cutaneous angiosarcoma: a diagnostic and therapeutic dilemma. Head Face Med; 2008;4:18
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  • [Title] Infraorbital cutaneous angiosarcoma: a diagnostic and therapeutic dilemma.
  • BACKGROUND: A cutaneous angiosarcoma is a rare malignant tumour of vascular endothelial cells with aggressive clinical behaviour and poor prognosis.
  • Diagnosis is often delayed due to its variable and often benign clinical appearance.
  • Histopathologic examination of the specimen diagnosed a cutaneous angiosarcoma.
  • Neither, finally achieved negative margins on permanent sections, nor a following chemotherapy could prevent the recurrence of the disease after five months and the patient's dead 21 months after the first diagnosis.
  • [MeSH-major] Facial Neoplasms / pathology. Hemangiosarcoma / pathology. Neoplasm Recurrence, Local / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Biopsy, Needle. Chemotherapy, Adjuvant. Combined Modality Therapy. Disease Progression. Fatal Outcome. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Staging. Radiotherapy, Adjuvant. Reoperation

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  • (PMID = 18694495.001).
  • [ISSN] 1746-160X
  • [Journal-full-title] Head & face medicine
  • [ISO-abbreviation] Head Face Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2533304
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80. Kuppahally SS, Litwin SE, Michaels AD: Endomyocardial biopsy of right atrial angiosarcoma guided by intracardiac echocardiography. Cardiol Res Pract; 2010;2010:681726
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  • [Title] Endomyocardial biopsy of right atrial angiosarcoma guided by intracardiac echocardiography.

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  • [Cites] Eur J Echocardiogr. 2007 Dec;8(6):505-6 [17015040.001]
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  • (PMID = 20585357.001).
  • [ISSN] 2090-0597
  • [Journal-full-title] Cardiology research and practice
  • [ISO-abbreviation] Cardiol Res Pract
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC2878669
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81. Andrews S, Wilcoxon R, Benda J, Jacobson G: Angiosarcoma following MammoSite partial breast irradiation. Breast Cancer Res Treat; 2010 Nov;124(1):279-82
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  • [Title] Angiosarcoma following MammoSite partial breast irradiation.
  • Angiosarcoma is a rare tumor of endothelial origin which commonly arises in small blood or lymphatic vessels.
  • To our knowledge, there are no reported cases in the literature or MammoSite registry which describe the occurrence of angiosarcoma in the treated breast following MammoSite brachytherapy.
  • This is a case report of a 74 year old female who developed angiosarcoma 4 years after receiving MammoSite balloon brachytherapy following surgical resection of a T1mic N0 M0 infiltrating ductal carcinoma.
  • [MeSH-major] Brachytherapy / adverse effects. Breast Neoplasms / radiotherapy. Carcinoma, Ductal, Breast / radiotherapy. Hemangiosarcoma / etiology. Neoplasms, Radiation-Induced / etiology

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  • (PMID = 20496164.001).
  • [ISSN] 1573-7217
  • [Journal-full-title] Breast cancer research and treatment
  • [ISO-abbreviation] Breast Cancer Res. Treat.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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82. Altamirano JC, Gratz SR, Wolnik KA: Investigation of pyrrolizidine alkaloids and their N-oxides in commercial comfrey-containing products and botanical materials by liquid chromatography electrospray ionization mass spectrometry. J AOAC Int; 2005 Mar-Apr;88(2):406-12
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  • PAs are also carcinogenic to animals, and they have been linked to the development of hepatocellular and skin squamous cell carcinomas as well as liver angiosarcomas.

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  • (PMID = 15859063.001).
  • [ISSN] 1060-3271
  • [Journal-full-title] Journal of AOAC International
  • [ISO-abbreviation] J AOAC Int
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Alkaloids; 0 / Indicators and Reagents; 0 / Oxides; 0 / Plant Preparations; 0 / Pyrrolizidine Alkaloids
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83. Patton KT, Deyrup AT, Weiss SW: Atypical vascular lesions after surgery and radiation of the breast: a clinicopathologic study of 32 cases analyzing histologic heterogeneity and association with angiosarcoma. Am J Surg Pathol; 2008 Jun;32(6):943-50
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  • [Title] Atypical vascular lesions after surgery and radiation of the breast: a clinicopathologic study of 32 cases analyzing histologic heterogeneity and association with angiosarcoma.
  • In 4 cases, endothelial atypia, consisting of nuclear and nucleolar enlargement, was noted.
  • Of the 21 patients, 17 are alive without disease, 1 is alive with disease, 1 died of breast carcinoma, 1 died of unknown causes, and 1 showed progressive histologic changes in the AVLs over a period of 5 years resulting in a well-differentiated angiosarcoma.
  • Follow-up in 8 patients with VT AVL (2 to 181 mo; mean 40 mo) disclosed that 6 were alive and well, but 2 of the 4 patients whose lesions displayed endothelial atypia had additional complications.
  • One patient underwent a mastectomy that revealed extensive residual AVL and the second developed a high-grade angiosarcoma after 14 months.
  • There seems to be an association of AVL with angiosarcoma that differs depending on the histologic features, with the VT AVLs having the higher risk.
  • In the 2 patients who developed angiosarcoma, morphologic evidence suggested AVLs to be a precursor rather than simply a risk factor.
  • [MeSH-major] Breast Neoplasms / pathology. Hemangiosarcoma / pathology. Neoplasms, Radiation-Induced / pathology

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  • (PMID = 18551753.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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84. Wang ZS, Zhan N, Xiong CL, Li H: Primary epithelioid angiosarcoma of the male breast: report of a case. Surg Today; 2007;37(9):782-6
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  • [Title] Primary epithelioid angiosarcoma of the male breast: report of a case.
  • We report a case of primary epithelioid angiosarcoma of the male breast.
  • Histopathological examination and immunohistochemical analysis confirmed a diagnosis of primary epithelioid angiosarcoma of the male breast, without axillary lymph node metastasis.
  • We review the relevant literature on this rare malignant tumor.
  • [MeSH-major] Breast Neoplasms, Male / pathology. Hemangiosarcoma / pathology. Neoplasms, Glandular and Epithelial / pathology

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  • (PMID = 17713733.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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85. Arribas-Garcia I, Domínguez MF, Alcalá-Galiano A, García AF, Valls JC, De Rasche EN: Oral primary angiosarcoma of the lower lip mucosa: report of a case in a 15-year-old boy. Head Neck; 2008 Oct;30(10):1384-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Oral primary angiosarcoma of the lower lip mucosa: report of a case in a 15-year-old boy.
  • BACKGROUND: Angiosarcomas are rare soft tissue malignant tumors with dismal prognosis.
  • METHODS AND RESULTS: We present the case of an inferior lip mucosal low-grade angiosarcoma in a 15-year-old boy treated exclusively with surgery.
  • Prompt and accurate diagnosis with adequate imaging modalities and multidisciplinary treatment are crucial for optimal management of these neoplasms.
  • [MeSH-major] Hemangiosarcoma. Lip Neoplasms

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  • [Copyright] Copyright (c) 2008 Wiley Periodicals, Inc. Head Neck 2008.
  • (PMID = 18286486.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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86. Stanislas S: [Splenic pathology. Case 5. Splenic angiosarcoma]. Ann Pathol; 2010 Jun;30(3):223-7
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  • [Title] [Splenic pathology. Case 5. Splenic angiosarcoma].
  • [Transliterated title] Pathologie splénique. Cas n(o) 5. Angiosarcome primitif splénique.
  • [MeSH-major] Hemangiosarcoma / pathology. Splenic Neoplasms / pathology

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  • (PMID = 20621601.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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87. Gajda M, Hommann M, Böttcher J, Henning K, Kaiser WA, Settmacher U, Katenkamp D: [Primary liposarcoma of the liver--a rare mesenchymal tumor]. Z Gastroenterol; 2007 Dec;45(12):1241-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Most often angiosarcomas have been reported.
  • [MeSH-major] Liposarcoma / diagnosis. Liver Neoplasms / diagnosis
  • [MeSH-minor] Cell Nucleus / pathology. Diagnosis, Differential. Female. Hepatectomy. Humans. Liver / pathology. Magnetic Resonance Imaging. Middle Aged

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  • (PMID = 18080225.001).
  • [ISSN] 0044-2771
  • [Journal-full-title] Zeitschrift für Gastroenterologie
  • [ISO-abbreviation] Z Gastroenterol
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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88. Wiedemann D, Bonaros N, Schachner T, Bonatti J, Laufer G, Kocher A: Cardiac angiosarcoma with reconstruction of the right atrium. Heart Surg Forum; 2010 Dec;13(6):E397-8
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  • [Title] Cardiac angiosarcoma with reconstruction of the right atrium.
  • A tumor highly suspicious for an angiosarcoma was identified by computed tomography and was suggestive of infiltration into the superior vena cava (SVC) and the majority of the right atrium.
  • [MeSH-major] Cardiovascular Surgical Procedures / methods. Heart Neoplasms / surgery. Hemangiosarcoma / surgery. Reconstructive Surgical Procedures / instrumentation. Reconstructive Surgical Procedures / methods

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  • (PMID = 21169152.001).
  • [ISSN] 1522-6662
  • [Journal-full-title] The heart surgery forum
  • [ISO-abbreviation] Heart Surg Forum
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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89. Lin N, Uchi H, Moroi Y, Fukiwake N, Dainichi T, Takeuchi S, Takahara M, Tu Y, Furue M, Urabe K: Significance of the expression of phosphorylated signal transducer and activator of transcription-3, -Akt, and -cyclin D1 in angiosarcoma. J Dermatol Sci; 2007 Oct;48(1):64-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Significance of the expression of phosphorylated signal transducer and activator of transcription-3, -Akt, and -cyclin D1 in angiosarcoma.
  • [MeSH-major] Cyclin D1 / metabolism. Hemangiosarcoma / metabolism. Proto-Oncogene Proteins c-akt / metabolism. STAT3 Transcription Factor / metabolism. Vascular Neoplasms / metabolism
  • [MeSH-minor] Biopsy. Endothelial Cells / metabolism. Endothelial Cells / pathology. Gene Expression Regulation, Neoplastic. Granuloma, Pyogenic / metabolism. Granuloma, Pyogenic / pathology. Hemangioma, Capillary / metabolism. Hemangioma, Capillary / pathology. Humans. Vascular Diseases / metabolism. Vascular Diseases / pathology


90. Newell-Fugate A, Lane E: Periaortic haemangiosarcoma in an African wild dog (Lycaon pictus). J S Afr Vet Assoc; 2009 Jun;80(2):108-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Periaortic haemangiosarcoma in an African wild dog (Lycaon pictus).
  • Histologically, the mass was consistent with a haemangiosarcoma.
  • [MeSH-major] Canidae. Heart Neoplasms / veterinary. Hemangiosarcoma / veterinary

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  • (PMID = 19831274.001).
  • [ISSN] 1019-9128
  • [Journal-full-title] Journal of the South African Veterinary Association
  • [ISO-abbreviation] J S Afr Vet Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] South Africa
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91. Sopena P, Uruburu E, Abreu P, Giménez A, Martínez B, Martínez C: [Angiosarcoma of the scalp: extension study with PET-CT]. Rev Esp Med Nucl; 2010 Mar-Apr;29(2):91-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Angiosarcoma of the scalp: extension study with PET-CT].
  • [Transliterated title] Angiosarcoma de cuero cabelludo: estudio de extensión con PET-TAC.
  • [MeSH-major] Bone Neoplasms / secondary. Head and Neck Neoplasms / pathology. Hemangiosarcoma / secondary. Positron-Emission Tomography. Scalp / pathology. Skin Neoplasms / secondary. Tomography, X-Ray Computed


92. Yoon TY, Kim HJ, Kim JW, Kim MK, Lee JY: Bowen's disease concealed by purpura. J Dermatol; 2007 Jan;34(1):65-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bowen's disease concealed by purpura.
  • Bowen's disease (BD) is a squamous cell carcinoma in situ characterized by a well-demarcated scaly erythematous thin plaque with an irregular outline.
  • However, angiosarcoma has not usually been mentioned in the differential diagnosis of BD before.
  • Herein, we describe two cases of BD presenting as purpura on the scalp of the elderly with an initial clinical suspicion of angiosarcoma.
  • [MeSH-major] Bowen's Disease / complications. Purpura / complications. Scalp. Skin Neoplasms / complications
  • [MeSH-minor] Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans

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  • (PMID = 17204105.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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93. Lo Presti M, Mazzella C, Monfrecola A, Falleti J: Angiosarcoma mimicking rhinophyma. Dermatol Res Pract; 2010;2010:365173
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma mimicking rhinophyma.
  • During that time the patient underwent several dermatological consultations, and all produced the same diagnosis: rhinophyma.
  • Punch biopsy was performed, and histopathology and immunohistochemical studies were consistent with cutaneous angiosarcoma.
  • This is the report of a face angiosarcoma with an unusual and very deceptive clinical presentation.

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  • [Cites] Clin Exp Dermatol. 2009 Oct;34(7):e227-8 [19302586.001]
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  • (PMID = 20631905.001).
  • [ISSN] 1687-6113
  • [Journal-full-title] Dermatology research and practice
  • [ISO-abbreviation] Dermatol Res Pract
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC2902059
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94. Ravi V, Benjamin RS: Systemic therapy for cardiac sarcomas. Methodist Debakey Cardiovasc J; 2010 Jul-Sep;6(3):57-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Systemic therapy for cardiac sarcomas.
  • Cardiac sarcomas create 2 risks: local problems and metastatic disease.
  • Most frequently, the histologies are angiosarcoma and high-grade pleomorphic unclassified sarcoma (formerly called MFH or malignant fibrous histiocytoma).
  • There is also a clinical-pathological entity without distinctive histological features of tumors that originate in the pulmonary artery and are referred to as pulmonary artery sarcomas or intimal sarcomas of the pulmonary artery.
  • Conventional wisdom indicates that soft-tissue sarcomas are poorly responsive to chemotherapy.
  • Attempts to concentrate on the local problem only with therapies up to and including cardiac transplantation have been unsuccessful due to the high rate of fatal metastatic disease.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Heart Neoplasms / drug therapy. Sarcoma / drug therapy

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  • (PMID = 20834213.001).
  • [ISSN] 1947-6094
  • [Journal-full-title] Methodist DeBakey cardiovascular journal
  • [ISO-abbreviation] Methodist Debakey Cardiovasc J
  • [Language] eng
  • [Publication-type] Journal Article; Portraits
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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95. Kajo K, Macháleková K, Pauer M: [Retiform hemangioendotelioma in a 8-year-old girl--case report]. Cesk Patol; 2009 Jul;45(3):72-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Retiform hemangioendotelioma in a 8-year-old girl--case report].
  • Retiform hemangioendothelioma (RHE) is a rare vascular tumoriform lesion characterized by rete testis--like vascular structures.
  • RHE belongs to a group of vascular tumors of intermediate malignancy and together with Dabska tumor form a category of so-called hobnail hemangioendotheliomas.
  • Histologically, the tumor consisted of a net of vessel formations with retiform appearance and prominent endothelial nuclei.
  • Other benign and malignant vascular lesions with hobnail cells (hemangioma, angiosarcoma) have to be considered in differential diagnosis.
  • [MeSH-major] Hemangioendothelioma / pathology. Vascular Neoplasms / pathology

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  • (PMID = 19764161.001).
  • [ISSN] 1210-7875
  • [Journal-full-title] Československá patologie
  • [ISO-abbreviation] Cesk Patol
  • [Language] slo
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Czech Republic
  • [Chemical-registry-number] 0 / Lewis Blood-Group System
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96. Astudillo L, Cron C, Gomez-Brouchet A, Couret B, Arlet-Suau E: [Angiosarcoma of the aorta]. Rev Med Interne; 2007 Oct;28(10):718-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Angiosarcoma of the aorta].
  • [Transliterated title] Angiosarcome épithélioïde de l'aorte.
  • Histopathology revealed an epithelioid angiosarcoma of the aorta.

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  • (PMID = 17587469.001).
  • [ISSN] 0248-8663
  • [Journal-full-title] La Revue de medecine interne
  • [ISO-abbreviation] Rev Med Interne
  • [Language] FRE
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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97. Craddock KJ, Labonte S, Ghazarian D: Anaplastic Kaposi sarcoma resembling epithelioid angiosarcoma in an HIV-positive man. Eur J Dermatol; 2008 May-Jun;18(3):358-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anaplastic Kaposi sarcoma resembling epithelioid angiosarcoma in an HIV-positive man.
  • [MeSH-major] AIDS-Related Opportunistic Infections / diagnosis. HIV Infections / complications. Hemangiosarcoma / diagnosis. Herpesvirus 8, Human. Sarcoma, Kaposi / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Immunohistochemistry. Male. Nuclear Proteins / metabolism. Phosphoproteins / metabolism. Skin / pathology


98. Raina V, Sengar M, Shukla NK, Deo SS, Mohanty BK, Sharma D, Ray R, Das P, Rath GK: Complete response from thalidomide in angiosarcoma after treatment of breast cancer. J Clin Oncol; 2007 Mar 1;25(7):900-1
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Complete response from thalidomide in angiosarcoma after treatment of breast cancer.
  • [MeSH-major] Breast Neoplasms / drug therapy. Hemangiosarcoma / drug therapy. Thalidomide / therapeutic use

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  • (PMID = 17327613.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 4Z8R6ORS6L / Thalidomide
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99. Pazona JF, Gupta R, Wysock J, Schaeffer AJ, Smith ND: Angiosarcoma of bladder: long-term survival after multimodal therapy. Urology; 2007 Mar;69(3):575.e9-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma of bladder: long-term survival after multimodal therapy.
  • Angiosarcoma of the bladder is extremely rare and carries a dismal prognosis because of the uniformly high-grade and aggressive tumor biology of the neoplasm.
  • We report the long-term disease-free survival of 1 patient, treated with multimodal therapy, whom we have previously reported on.
  • Six years after the initial presentation, the patient died, and the postmortem analysis revealed no evidence of residual disease.
  • Our case represents the longest reported survival of a patient with angiosarcoma of the bladder.
  • [MeSH-major] Hemangiosarcoma / surgery. Urinary Bladder Neoplasms / surgery

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  • (PMID = 17382176.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD31
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