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1. Sher T, Hennessy BT, Valero V, Broglio K, Woodward WA, Trent J, Hunt KK, Hortobagyi GN, Gonzalez-Angulo AM: Primary angiosarcomas of the breast. Cancer; 2007 Jul 1;110(1):173-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary angiosarcomas of the breast.
  • BACKGROUND: The purpose of the study was to describe the clinicopathologic characteristics and clinical outcomes of patients with primary breast angiosarcoma.
  • METHODS: The institutional database was searched to identify breast angiosarcoma patients seen between 1965 and 2002.
  • Median tumor size at diagnosis was 5.5 cm.
  • CONCLUSIONS: Breast angiosarcoma is frequently advanced at diagnosis and has a tendency for local-regional recurrence.
  • [MeSH-major] Breast Neoplasms / pathology. Hemangiosarcoma / pathology

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  • [Copyright] Copyright (c) 2007 American Cancer Society.
  • (PMID = 17541936.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / L30 CA123630; United States / NCI NIH HHS / CA / L30 CA123630-01; United States / NCI NIH HHS / CA / L30 CA123630-02
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Estrogen; 0 / Receptors, Progesterone
  • [Other-IDs] NLM/ NIHMS283619; NLM/ PMC4329779
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2. Antonescu CR, Yoshida A, Guo T, Chang NE, Zhang L, Agaram NP, Qin LX, Brennan MF, Singer S, Maki RG: KDR activating mutations in human angiosarcomas are sensitive to specific kinase inhibitors. Cancer Res; 2009 Sep 15;69(18):7175-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] KDR activating mutations in human angiosarcomas are sensitive to specific kinase inhibitors.
  • Angiosarcomas (AS) represent a heterogeneous group of malignant vascular tumors occurring not only in different anatomic locations but also in distinct clinical settings, such as radiation or associated chronic lymphedema.
  • Although representing only 1% to 2% of soft tissue sarcomas, vascular sarcomas provide unique insight into the general process of tumor angiogenesis.
  • These data provide a basis for the activity of vascular endothelial growth factor receptor-directed therapy in the treatment of primary and radiation-induced AS.

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  • (PMID = 19723655.001).
  • [ISSN] 1538-7445
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA047179-15A29002; United States / NCI NIH HHS / CA / P01 CA047179; United States / NCI NIH HHS / CA / P01 CA047179-15A29002; United States / NCI NIH HHS / CA / P01CA47179
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / Vascular Endothelial Growth Factor Receptor-2
  • [Other-IDs] NLM/ NIHMS135278; NLM/ PMC2763376
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3. Mankey CC, McHugh JB, Thomas DG, Lucas DR: Can lymphangiosarcoma be resurrected? A clinicopathological and immunohistochemical study of lymphatic differentiation in 49 angiosarcomas. Histopathology; 2010 Feb;56(3):364-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Can lymphangiosarcoma be resurrected? A clinicopathological and immunohistochemical study of lymphatic differentiation in 49 angiosarcomas.
  • AIMS: The term lymphangiosarcoma has largely been abandoned in the current classification of endothelial neoplasms.
  • Recently, a number of lymphatic-associated antibodies have been developed for immunohistochemistry, which frequently stain angiosarcomas, implying lymphatic or mixed lymphatic and blood vascular differentiation is common.
  • METHODS AND RESULTS: Forty-nine angiosarcomas in tissue microarrays were analysed with D2-40 and antibodies to Prox-1 and vascular endothelial growth factor receptor (VEGFR)-3.
  • CONCLUSIONS: Lymphatic differentiation is common in angiosarcoma, certain subsets show greater lymphatic differentiation than others, and lymphangiosarcoma may be defined pathologically, rather than clinically.
  • [MeSH-major] Antibodies, Monoclonal. Endothelium, Lymphatic / pathology. Hemangiosarcoma / pathology. Lymphangiosarcoma / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Antibodies, Monoclonal, Murine-Derived. Cell Differentiation. Female. Homeodomain Proteins / metabolism. Humans. Immunohistochemistry. Male. Middle Aged. Receptors, Vascular Endothelial Growth Factor / metabolism. Tissue Array Analysis. Tumor Suppressor Proteins / metabolism

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  • (PMID = 20459536.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Homeodomain Proteins; 0 / Tumor Suppressor Proteins; 0 / monoclonal antibody D2-40; 0 / prospero-related homeobox 1 protein; EC 2.7.10.1 / Receptors, Vascular Endothelial Growth Factor
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4. Iwamoto K, Suzuki S, Kurata A, Sato K, Niki J, Miyazaki T, Utsuki S, Oka H, Fujii K, Kan S, Masuzawa M: Efficacy of selective transarterial chemotherapy using a port systemfor angiosarcomas of the face and scalp. Interv Neuroradiol; 2008 Jun 30;14(2):137-41

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Efficacy of selective transarterial chemotherapy using a port systemfor angiosarcomas of the face and scalp.
  • SUMMARY: Angiosarcoma is a rare, highly malignant tumor with a poor clinical outcome.
  • From January 2004 to September 2005, we advocated transarterial chemotherapy using a port system for four patients with angiosarcomas of the face and scalp.
  • Transarterial infusion chemotherapy using such a port system may be particularly effective for angiosarcoma in the early stages because small lesions with limited invasion mean a small territory of blood supply to be covered, and useful life was possible because the port system embedded in subcutaneous tissue allows treatment in an out-patient clinic.

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  • (PMID = 20557754.001).
  • [ISSN] 1591-0199
  • [Journal-full-title] Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences
  • [ISO-abbreviation] Interv Neuroradiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3313716
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5. Khalil MF, Thomas A, Aassad A, Rubin M, Taub RN: Epithelioid Angiosarcoma of the Small Intestine After Occupational Exposure to Radiation and Polyvinyl Chloride: A case Report and Review of Literature. Sarcoma; 2005;9(3-4):161-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epithelioid Angiosarcoma of the Small Intestine After Occupational Exposure to Radiation and Polyvinyl Chloride: A case Report and Review of Literature.
  • Angiosarcomas represent 1-2% of soft tissue sarcomas and most frequently occur in the subcutis.
  • The association between angiosarcomas and certain toxic chemical substances or previous external-beam radiation therapy is well documented.

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  • (PMID = 18521426.001).
  • [ISSN] 1357-714X
  • [Journal-full-title] Sarcoma
  • [ISO-abbreviation] Sarcoma
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC2395632
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6. van Geel AN, den Bakker MA: Bilateral angiosarcoma of the breast in a fourteen-year-old child. Rare Tumors; 2009;1(2):e38

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bilateral angiosarcoma of the breast in a fourteen-year-old child.
  • Malignant vascular tumors are rare and angiosarcomas of the breast in patients under 21 years of age are exceedingly uncommon.
  • In this report an angiosarcoma in the breast of a 14-year-old girl is described.
  • She died nine months after mastectomy with recurrent disease in the bones and the contralateral breast.
  • The etiology of most primary angiosarcomas is unknown.
  • Secondary angiosarcomas can develop after radiotherapy and chronic lymphedema.
  • The histology of this angiosarcoma is illustrated.

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  • (PMID = 21139917.001).
  • [ISSN] 2036-3613
  • [Journal-full-title] Rare tumors
  • [ISO-abbreviation] Rare Tumors
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2994455
  • [Keywords] NOTNLM ; angiosarcoma / breast. / infancy
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7. Manner J, Radlwimmer B, Hohenberger P, Mössinger K, Küffer S, Sauer C, Belharazem D, Zettl A, Coindre JM, Hallermann C, Hartmann JT, Katenkamp D, Katenkamp K, Schöffski P, Sciot R, Wozniak A, Lichter P, Marx A, Ströbel P: MYC high level gene amplification is a distinctive feature of angiosarcomas after irradiation or chronic lymphedema. Am J Pathol; 2010 Jan;176(1):34-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] MYC high level gene amplification is a distinctive feature of angiosarcomas after irradiation or chronic lymphedema.
  • Angiosarcomas (AS) are rare vascular malignancies that arise either de novo as primary tumors or secondary to irradiation or chronic lymphedema.
  • The cytogenetics of angiosarcomas are poorly characterized.
  • Fluorescence in situ hybridization analysis in 28 primary and 33 secondary angiosarcomas (31 tumors secondary to irradiation, 2 tumors secondary to chronic lymphedema) confirmed high level amplification of MYC on chromosome 8q24.21 as a recurrent genetic alteration found exclusively in 55% of AS secondary to irradiation or chronic lymphedema, but not in primary AS.
  • This finding may have implications both for the diagnosis and treatment of these tumors.
  • [MeSH-major] Gene Amplification / genetics. Hemangiosarcoma / etiology. Hemangiosarcoma / genetics. Lymphedema / complications. Proto-Oncogene Proteins c-myc / genetics. Radiotherapy / adverse effects
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Chromosome Deletion. Chronic Disease. DNA Copy Number Variations / genetics. Female. Genetic Loci / genetics. Homozygote. Humans. In Situ Hybridization, Fluorescence. Male. Middle Aged

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  • (PMID = 20008140.001).
  • [ISSN] 1525-2191
  • [Journal-full-title] The American journal of pathology
  • [ISO-abbreviation] Am. J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Proto-Oncogene Proteins c-myc
  • [Other-IDs] NLM/ PMC2797867
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8. Penel N, Lansiaux A, Adenis A: Angiosarcomas and taxanes. Curr Treat Options Oncol; 2007 Dec;8(6):428-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcomas and taxanes.
  • Angiosarcomas (AS) are a heterogeneous group of rare and aggressive malignancies.
  • The French Sarcoma Group has conducted a phase II clinical trial, which states the benefit of weekly paclitaxel in patients with unresectable or metastatic AS.
  • [MeSH-major] Antineoplastic Agents, Phytogenic / therapeutic use. Hemangiosarcoma / drug therapy. Taxoids / therapeutic use
  • [MeSH-minor] Antibiotics, Antineoplastic / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Disease-Free Survival. Doxorubicin / administration & dosage. Humans. Paclitaxel / therapeutic use. Radiotherapy, Adjuvant

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  • (PMID = 18066504.001).
  • [ISSN] 1534-6277
  • [Journal-full-title] Current treatment options in oncology
  • [ISO-abbreviation] Curr Treat Options Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Antineoplastic Agents, Phytogenic; 0 / Taxoids; 15H5577CQD / docetaxel; 80168379AG / Doxorubicin; P88XT4IS4D / Paclitaxel
  • [Number-of-references] 40
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9. Asgari MM, Cockerell CJ, Weitzul S: The head-tilt maneuver: a clinical aid in recognizing head and neck angiosarcomas. Arch Dermatol; 2007 Jan;143(1):75-7
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  • [Title] The head-tilt maneuver: a clinical aid in recognizing head and neck angiosarcomas.
  • BACKGROUND: Cutaneous angiosarcoma is a rare, life-threatening tumor that is often initially misdiagnosed.
  • This delay in diagnosis can affect tumor growth, metastatic potential, and prognosis.
  • [MeSH-major] Head Movements. Head and Neck Neoplasms / diagnosis. Hemangiosarcoma / diagnosis. Skin / pathology
  • [MeSH-minor] Diagnosis, Differential. Face. Head-Down Tilt. Humans. Male. Torsion Abnormality

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  • (PMID = 17224545.001).
  • [ISSN] 0003-987X
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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10. Abedalthagafi M, Rushing EJ, Auerbach A, Desouki MM, Marwaha J, Wang Z, Fanburg-Smith JC: Sporadic cutaneous angiosarcomas generally lack hypoxia-inducible factor 1alpha: a histologic and immunohistochemical study of 45 cases. Ann Diagn Pathol; 2010 Feb;14(1):15-22
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  • [Title] Sporadic cutaneous angiosarcomas generally lack hypoxia-inducible factor 1alpha: a histologic and immunohistochemical study of 45 cases.
  • Cutaneous angiosarcoma (AS) is a rare malignant neoplasm of dermis composed of infiltrating cells of endothelial phenotype with overall poor prognosis.
  • Although autocrine stimulation by vascular endothelial growth factor secretion may play a role in the pathogenesis of angiosarcoma, its mechanism has not been fully established.
  • The stability of HIF can regulate key proteins in angiogenesis and the alpha-subunit has been found in epithelial tumors, only 1 case of human retroperitoneal angiosarcoma, and rare vascular proliferations and tumors in knockout mice.
  • Cases coded as "angiosarcoma" of dermis were culled and re-reviewed for inclusion as AS, based on patient folder, slides, and obtained immunohistochemistry including CD31 and smooth muscle actin (SMA).
  • There was no history of other primary, lymphedema, radiation, breast-associated, or thorotrast-induced angiosarcoma.
  • Histopathologically, most tumors were vasoformative, with either solid architecture (n = 35) or papillary endothelial hyperplasia-like foci (n = 7).
  • CD31 highlighted malignant endothelial cells.
  • Treatment and follow-up data were only available on 4 cases: 2 died of disease within 4 years, 2 others had known recurrence within 2 years.
  • Cutaneous angiosarcoma is largely found on the scalp of older individuals.
  • Requirement for diagnosis includes extravascular proliferation of atypical endothelial cells with mitotic activity in vasoformative, solid, and papillary patterns.
  • Cutaneous angiosarcoma generally lacks HIF-1alpha expression.
  • [MeSH-major] Dermis / metabolism. Hemangiosarcoma / metabolism. Hypoxia-Inducible Factor 1, alpha Subunit / metabolism. Neovascularization, Pathologic / metabolism. Skin Neoplasms / metabolism

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  • [Copyright] Published by Elsevier Inc.
  • (PMID = 20123452.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / HIF1A protein, human; 0 / Hypoxia-Inducible Factor 1, alpha Subunit
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11. Baumhoer D, Gunawan B, Becker H, Füzesi L: Comparative genomic hybridization in four angiosarcomas of the female breast. Gynecol Oncol; 2005 May;97(2):348-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparative genomic hybridization in four angiosarcomas of the female breast.
  • OBJECTIVE: Angiosarcomas represent a heterogeneous group of malignant vascular tumors occurring in different anatomic sites.
  • In the female breast, they account for less than 1% of all malignant tumors and mainly develop as secondary angiosarcomas after prior irradiation.
  • Data on cytogenetic findings in angiosarcomas are scarce and up to now no characteristic primary aberrations have been established.
  • We herein add molecular cytogenetic findings in another 4 angiosarcomas to 11 previously reported cases.
  • METHODS: We investigated four angiosarcomas of the female breast (three primary angiosarcomas and one secondary tumor after irradiation for breast cancer) for DNA copy number changes using comparative genomic hybridization (CGH).
  • RESULTS: All angiosarcomas revealed aberrant karyotypes including multiple DNA copy number changes involving various chromosomes.
  • CONCLUSIONS: Angiosarcoma of the female breast represents a genetically heterogeneous tumor entity without a readily identifiable pattern of common chromosomal alterations.
  • However, reviewing the cytogenetic literature on angiosarcomas of different sites, gains at 8q and 20p appear to emerge as the most frequent aberrations in at least a subset of these tumors.
  • [MeSH-major] Breast Neoplasms / genetics. Hemangiosarcoma / genetics

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  • (PMID = 15863129.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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12. Arbiser JL, Bonner MY, Berrios RL: Hemangiomas, angiosarcomas, and vascular malformations represent the signaling abnormalities of pathogenic angiogenesis. Curr Mol Med; 2009 Nov;9(8):929-34
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  • [Title] Hemangiomas, angiosarcomas, and vascular malformations represent the signaling abnormalities of pathogenic angiogenesis.
  • Angiogenesis is a major factor in the development of benign, inflammatory, and malignant processes of the skin.
  • Endothelial cells are the effector cells of angiogenesis, and understanding their response to growth factors and inhibitors is critical to understanding the pathogenesis and treatment of skin disease.
  • Hemangiomas, benign tumors of endothelial cells, represent the most common tumor of childhood.
  • Furthermore, we have studied malignant vascular tumors, including hemangioendothelioma and angiosarcoma and have shown distinct signaling abnormalities in these tumors.
  • The incidence of these tumors is expected to rise due to environmental insults, such as radiation and lumpectomy for breast cancer, dietary and industrial carcinogens (hepatic angiosarcoma), and chronic ultraviolet exposure and potential Agent Orange exposure.
  • I hypothesize that hemangiomas, angiosarcomas, and vascular malformations represent the extremes of signaling abnormalities seen in pathogenic angiogenesis.
  • [MeSH-major] Hemangioma / blood supply. Hemangiosarcoma / blood supply. Neovascularization, Pathologic / pathology. Signal Transduction. Vascular Malformations / physiopathology

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  • (PMID = 19925405.001).
  • [ISSN] 1875-5666
  • [Journal-full-title] Current molecular medicine
  • [ISO-abbreviation] Curr. Mol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 81
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13. Taylor KL, Oates RK, Grane R, Leaman DW, Borden EC, Lindner DJ: IFN-alpha1,8 inhibits tumor-induced angiogenesis in murine angiosarcomas. J Interferon Cytokine Res; 2006 May;26(5):353-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] IFN-alpha1,8 inhibits tumor-induced angiogenesis in murine angiosarcomas.
  • Interferon-alpha (IFN-alpha) has proved effective in the treatment of hemangiomas, hemangioblastomas, and Kaposi's sarcoma.
  • To investigate the ability of IFNs to inhibit angiosarcoma, we used two transformed murine endothelial cell lines that form angiosarcomas in vivo.
  • SVR and MS1-VEGF cell lines express oncogenic H-ras or vascular endothelial growth factor (VEGF), respectively.
  • Both recombinant IP-10 and IFN-alpha1,8 inhibited human umbilical vein endothelial cell (HUVEC) vessel formation in the fibrin gel assay, a three-dimensional culture model of angiogenesis, by 56% at 25 ng/mL and 50% at 1.2 ng/mL, respectively (p < 0.001).
  • [MeSH-major] Hemangiosarcoma / blood supply. Hemangiosarcoma / drug therapy. Interferon-alpha / therapeutic use. Neovascularization, Pathologic / drug therapy
  • [MeSH-minor] Animals. Cell Line, Tumor. Cell Proliferation / drug effects. Chemokine CXCL10. Chemokines, CXC / biosynthesis. Chemokines, CXC / blood. Disease Progression. Humans. Mice. Xenograft Model Antitumor Assays

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  • (PMID = 16689662.001).
  • [ISSN] 1079-9907
  • [Journal-full-title] Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research
  • [ISO-abbreviation] J. Interferon Cytokine Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01CA089344-04
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chemokine CXCL10; 0 / Chemokines, CXC; 0 / Interferon-alpha
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14. Smith KJ, Skelton H: Kaposi's sarcoma-like angiosarcomas may reflect a common lymphatic endothelium differentiation pattern as Kaposi's sarcoma in association with chronic lymphedema. Int J Dermatol; 2006 May;45(5):623-6
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  • [Title] Kaposi's sarcoma-like angiosarcomas may reflect a common lymphatic endothelium differentiation pattern as Kaposi's sarcoma in association with chronic lymphedema.
  • [MeSH-major] Lymphedema / complications. Sarcoma, Kaposi / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Hemangiosarcoma / complications. Hemangiosarcoma / diagnosis. Humans

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  • (PMID = 16700808.001).
  • [ISSN] 0011-9059
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 40
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15. McIntosh BC, Narayan D: Head and neck angiosarcomas. J Craniofac Surg; 2005 Jul;16(4):699-703
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Head and neck angiosarcomas.
  • Angiosarcoma of the head and neck is a rare and lethal neoplasm.
  • Data from the Connecticut Tumor Registry was analyzed for all head and neck angiosarcomas between 1980 and 2001.
  • The authors also present the first reported case of familial angiosarcoma of the head and neck region.
  • The 1-year mortality was 48% for all patients with angiosarcomas (38% for males, 69% for females).
  • [MeSH-major] Head and Neck Neoplasms / epidemiology. Hemangiosarcoma / epidemiology
  • [MeSH-minor] Adult. Age Distribution. Aged. Chemotherapy, Adjuvant. Connecticut / epidemiology. Disease-Free Survival. Female. Humans. Incidence. Male. Middle Aged. Sex Distribution. Siblings

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  • (PMID = 16077321.001).
  • [ISSN] 1049-2275
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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16. Agulnik M, Okuno SH, Von Mehren M, Jovanovic B, Brockstein B, Benjamin RS, Evens AM: An open-label multicenter phase II study of bevacizumab for the treatment of angiosarcoma. J Clin Oncol; 2009 May 20;27(15_suppl):10522

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An open-label multicenter phase II study of bevacizumab for the treatment of angiosarcoma.
  • : 10522 Background: The limited therapeutic options and dismal prognosis for patients (pts) with angiosarcomas (AS) provide a strong rationale for the evaluation of new therapies.
  • METHODS: The study was a two-stage design in which patients with newly diagnosed or relapsed/refractory AS and epithelioid hemangioendotheliomas were treated with bevacizumab 15 mg/kg IV every 3 weeks.
  • Further studies with bevacizumab in combination with chemotherapy should be explored in this disease.

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  • (PMID = 27963911.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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17. Pink D, Rahm J, Schoeler D, Schoenknecht TM, Reichardt P: Activity of paclitaxel in radiation induced and other secondary angiosarcomas. J Clin Oncol; 2009 May 20;27(15_suppl):10578

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Activity of paclitaxel in radiation induced and other secondary angiosarcomas.
  • : 10578 Background: Angiosarcomas (AS) represent 1-2% of adult soft tissue sarcomas and can arise anywhere in the body.
  • Paclitaxel has shown an exceptionally high activity of 75-89% in angiosarcomas of the face and scalp and to a lesser and less consitent degree of 15-58% in other disease locations.
  • We report on a retrospectice single center experience with chemotherapy in 17 patients (pts.) with secondary angiosarcomas (SAS).
  • 12 female patients suffered from angiosarcoma of the breast/thoracic wall following operation and radiation + chemotherapy of a primary breast cancer with an interval of a median of 6 years (range 2-15 years).
  • 3 pts. remain free of disease.
  • All 14 patients with recurrent/metastatic disease were treated with chemotherapy.
  • Responses were 8 PR with a median PFS of 6 months (range 3-23 months), and 1 SD (PFS 4 months) with a disease control rate of 75%.
  • CONCLUSIONS: Paclitaxel shows high activity in SAS, comparable to the results in face and scalp angiosarcomas and can be considered a standard treatment option.

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  • (PMID = 27963758.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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18. Galaychuk I: Breast sarcomas: Is now the time to change our mind? J Clin Oncol; 2009 May 20;27(15_suppl):e21524

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Breast sarcomas: Is now the time to change our mind?
  • : e21524 Background: Primary breast sarcoma usually was considered a rare malignant disease [Adem et al., 2004].
  • The aim of this study is to show the incidence of breast sarcoma in the region with female population of about 600,000.
  • METHODS: Retrospective comparative analysis of breast sarcoma and breast cancer incidence in female of Ternopil region for 2000 - 2008.
  • RESULTS: The total of 101 cases of breast sarcoma was diagnosed in female of 39 - 76 years of age.
  • Every year about 11 (6-18) primary breast sarcomas and 256 (233-279) patients with primary breast cancer were detected.
  • The incidence rate of breast sarcoma was 1.14 per 100,000 women in 2000, 2.94 (in 2001), 1.48 (2002), 0.99 (2003), 2.16 (2004), 1.67 (2005), 2.53 (2006), 2.03 (2007) and 1.87/100,000 in 2008.
  • Breast sarcoma consisted of 2.5% of the breast malignancies in 2000, 6.5% (in 2001), 3.3% (2002), 2.6% (2003), 5.4% (2004), 4.1% (2005), 5.9% (2006), 4.4% (2007) and 4.7% in 2008.
  • Pathohistologic examination revealed angiosarcoma in 92.1% of cases.
  • Thus, our findings are significantly different than data of other authors: f.e., the incidence of primary breast sarcoma is at 45 new cases per 10 million women [Confavreux et al., 2003], or 17 new cases per million women [Moore and Kinne, 1996], and breast sarcoma accounting for 0.0006% of breast malignancies which were diagnosed in 1910-2000 [Adem, 2004].
  • Taking into account all historical and recent data we can suggest beginning of biological changing in correlation between breast malignant tumors-carcinoma and sarcoma.
  • CONCLUSIONS: Our statistical finding shows that incidence of breast sarcoma is 1.87 (0.99-2.94) per of 100,000 female population, and now sarcomas consist of 4.4% (2.5-6.5%) of all malignant breast tumors.
  • Angiosarcoma is a most common (92.1%) morphological type of breast sarcomas.

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  • (PMID = 27963454.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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19. Ramon Y Cajal T, Mazarico J, Lopez Pousa A, Quintana M, Sala N, Altabas M, Sebio A, Robert L, Alonso C, Barnadas A: Clinical features and outcome in primary breast sarcomas (BS): Analysis of a single-institution experience. J Clin Oncol; 2009 May 20;27(15_suppl):e21520

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical features and outcome in primary breast sarcomas (BS): Analysis of a single-institution experience.
  • Pathology: 17 cistosarcoma phylodes (CPh), 9 angiosarcoma, 2 extraesqueletical osteosarcoma, 2 fibrosarcomas, 1 liposarcoma, 1 leiomiosarcoma, 1 malignant fibrous histiocitoma (2.9%).

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  • (PMID = 27963450.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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20. Moreno-Vega A, Chavarría N, Rubio J, Villandiego I, Estepa R, Gordon M, Salvador J, Jimenez E: Primary breast sarcoma: Clinical and retrospective analysis of cases from Jerez General Hospital, Spain. J Clin Oncol; 2009 May 20;27(15_suppl):e21526

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary breast sarcoma: Clinical and retrospective analysis of cases from Jerez General Hospital, Spain.
  • : e21526 Background: Primary sarcomas of the breast (PBS) are a heterogeneous group of tumors from stromal breast, infrequent (0.1% of BC).
  • Diagnosis and treatment is unclear.
  • We analysed diseases outcomes (disease free survival, DFS) by histology high risk factors (tumor size, histology, and proliferation index).
  • RESULTS: Seven cases of PBS (1 male/6 female) were reviewed, from 790 BC diagnosed (0.8%): 2 angiosarcomas (AS), 1 malignant fibrous histiocytoma, 2 undifferentiated, one osteoclastic and other spindle-cell sarcoma.
  • CONCLUSIONS: PBS are rare and difficult diagnosis tumors.
  • There are few series published, without prospective studies to evaluate an adequate therapy, diagnosis and valuable prognostic factors.
  • Our incidence was high, but the independent pathology analysis confirmed all histopathological diagnosis.
  • This review included novel IHC and IRM images, considered necessary for diagnosis and personalized treatment.

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  • (PMID = 27963456.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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21. Shin SJ, Lesser M, Rosen PP: Hemangiomas and angiosarcomas of the breast: diagnostic utility of cell cycle markers with emphasis on Ki-67. Arch Pathol Lab Med; 2007 Apr;131(4):538-44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hemangiomas and angiosarcomas of the breast: diagnostic utility of cell cycle markers with emphasis on Ki-67.
  • CONTEXT: Vascular tumors comprise a minor subgroup of tumors arising in the breast and represent variants of hemangiomas and angiosarcomas.
  • Diagnostic challenges may arise when differentiating hemangiomas from types I and II angiosarcomas.
  • Ki-67 expression has been used as an adjunct to distinguish between benign and malignant lesions exhibiting histologic overlap at various anatomic sites.
  • OBJECTIVE: To investigate the utility of Ki-67 and other cell cycle regulatory proteins (S-phase kinase-associated protein 2 [Skp2], p27, and cyclin D1) in the differential diagnosis of mammary vascular lesions.
  • DESIGN: Thirty-four vascular tumors (21 hemangiomas and 13 angiosarcomas) of the breast were studied.
  • RESULTS: The mean value of Ki-67 index was statistically different when comparing hemangiomas and angiosarcomas (P < .001).
  • Angiosarcomas were typically positive for Skp2, whereas hemangiomas were negative (P < .001).
  • Sensitivity and specificity cutoffs for Ki-67 index to distinguish hemangiomas from angiosarcomas showed a candidate cutoff point of 175.
  • The mean values of Ki-67 of low-grade angiosarcomas were significantly different from all hemangiomas (P < .001) and also different from the subset of atypical hemangiomas (P = .02).
  • Sensitivity and specificity cutoffs for Ki-67 index to distinguish all hemangiomas from low-grade angiosarcomas showed a candidate cutoff point between 150 and 175.
  • Among angiosarcomas, positivity for Ki-67 was inversely related to that of p27 but not to Skp2 or cyclin D1.
  • CONCLUSIONS: Ki-67 index can be used as a diagnostic tool to distinguish between benign and malignant vascular lesions of the breast.
  • This can be particularly helpful in cases of histologic overlap such as low-grade angiosarcoma and hemangioma.
  • [MeSH-major] Breast Neoplasms / diagnosis. Breast Neoplasms, Male / diagnosis. Hemangioma / diagnosis. Hemangiosarcoma / diagnosis. Ki-67 Antigen / metabolism
  • [MeSH-minor] Biomarkers, Tumor / analysis. Cell Cycle. Cyclin D1 / metabolism. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Middle Aged. Proliferating Cell Nuclear Antigen / metabolism. S-Phase Kinase-Associated Proteins / metabolism. Sensitivity and Specificity

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  • (PMID = 17425381.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / Proliferating Cell Nuclear Antigen; 0 / S-Phase Kinase-Associated Proteins; 0 / p27 antigen; 136601-57-5 / Cyclin D1
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22. Al-Abbadi MA, Almasri NM, Al-Quran S, Wilkinson EJ: Cytokeratin and epithelial membrane antigen expression in angiosarcomas: an immunohistochemical study of 33 cases. Arch Pathol Lab Med; 2007 Feb;131(2):288-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytokeratin and epithelial membrane antigen expression in angiosarcomas: an immunohistochemical study of 33 cases.
  • CONTEXT: Expression of epithelial cell markers can occur in mesenchymal tumors and has been reported in angiosarcomas with variable frequency.
  • In these situations, establishing the diagnosis becomes problematic.
  • OBJECTIVE: To determine the expression of cytokeratin and epithelial membrane antigen in angiosarcoma.
  • DESIGN: To address this issue, 33 well-documented cases of angiosarcomas were retrieved from the archival material of Shands Hospital at the University of Florida, Gainesville, and Jackson Memorial Hospital at the University of Miami, Miami, Florida.
  • CONCLUSION: Cytokeratin and epithelial membrane antigen immunoreactivity in angiosarcomas is infrequent but may be encountered.
  • Interpretation of such expression should be done with caution and in conjunction with the characteristic clinical and morphologic features of the tumor as well as the expression of endothelial cell antigens.
  • [MeSH-major] Biomarkers, Tumor / analysis. Hemangiosarcoma / pathology. Keratins / metabolism. Mucin-1 / metabolism

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  • (PMID = 17284115.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Mucin-1; 68238-35-7 / Keratins
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23. Hodgson NC, Bowen-Wells C, Moffat F, Franceschi D, Avisar E: Angiosarcomas of the breast: a review of 70 cases. Am J Clin Oncol; 2007 Dec;30(6):570-3
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  • [Title] Angiosarcomas of the breast: a review of 70 cases.
  • OBJECTIVE: Angiosarcoma arising in the irradiated breast after breast-conserving therapy is being reported with increasing frequency.
  • The objective of this study was to review breast angiosarcomas diagnosed from 1981 to 2000 from our state cancer registry.
  • METHODS: A comprehensive review of a population-based registry, Florida Cancer Data System, identified 70 cases of breast angiosarcomas from 1981 to 2000.
  • RESULTS: Of the 70 cases at presentation, 39 were primary breast angiosarcomas (PBAs) and 31 were secondary breast angiosarcomas (SBAs).
  • In the SBA group the mean age of breast cancer diagnosis was 67.6.
  • The mean time to diagnosis of the angiosarcoma was 5.2 years after breast cancer irradiation.
  • At presentation 82% (n = 32) and 48% (n = 15), in the PBA and SBA groups, respectively had local disease (P = 0.003).
  • CONCLUSION: Angiosarcoma of the breast is rare and this study reports a review of 70 cases from 1980 to 2000.
  • Angiosarcoma after breast-conserving therapy is increasingly diagnosed in a small but significant portion of breast carcinoma survivors.
  • SBA patients present with more advance disease.
  • The aggressive nature of this disease demands further investigation of adjuvant therapy to prevent recurrence of disease after surgery.
  • [MeSH-major] Breast Neoplasms / etiology. Hemangiosarcoma / etiology. Mastectomy, Segmental / adverse effects. Neoplasms, Second Primary / etiology

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  • (PMID = 18091049.001).
  • [ISSN] 1537-453X
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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24. Stacher E, Gruber-Mösenbacher U, Halbwedl I, Dei Tos AP, Cavazza A, Papotti M, Carvalho L, Huber M, Ermert L, Popper HH: The VEGF-system in primary pulmonary angiosarcomas and haemangioendotheliomas: new potential therapeutic targets? Lung Cancer; 2009 Jul;65(1):49-55
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  • [Title] The VEGF-system in primary pulmonary angiosarcomas and haemangioendotheliomas: new potential therapeutic targets?
  • Malignant epitheloid vascular tumors (epitheloid haemangioendotheliomas and angiosarcomas) of the lung are very rare lesions often posing difficulties in diagnosis.
  • A blockade of members of the vascular endothelial growth factor (VEGF) system either by antibodies for their ligands or by kinase inhibitors has been increasingly used for the therapy of solid tumors.
  • Next, we investigated several factors of the VEGF-signalling pathway as well as Tie 2 in eight primary pulmonary epitheloid haemangioendotheliomas and ten primary pulmonary epitheloid angiosarcomas by means of immunohistochemistry using commercially available antibodies against VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGFR-2, VEGFR-3 and endothelium specific kinase Tie2.
  • [MeSH-major] Hemangioendothelioma, Epithelioid / metabolism. Hemangiosarcoma / metabolism. Lung Neoplasms / metabolism. Receptors, Vascular Endothelial Growth Factor / metabolism. Vascular Endothelial Growth Factors / metabolism

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  • (PMID = 19100646.001).
  • [ISSN] 1872-8332
  • [Journal-full-title] Lung cancer (Amsterdam, Netherlands)
  • [ISO-abbreviation] Lung Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Vascular Endothelial Growth Factors; EC 2.7.10.1 / Receptor, TIE-2; EC 2.7.10.1 / Receptors, Vascular Endothelial Growth Factor
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25. Kaminaka C, Yamamoto Y, Yonei N, Furukawa F: Phenol application to angiosarcomas: implications and histologic studies. Int J Dermatol; 2009 May;48(5):470-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Phenol application to angiosarcomas: implications and histologic studies.
  • BACKGROUND: Cutaneous angiosarcoma (AS) is an aggressive endothelial sarcoma that arises in elderly people.
  • RESULTS: Phenol treatment induced a strong degeneration of tumor cells and endothelial cells in the dermis, when compared with nontreated areas.
  • Positive staining of tumor cells and/or endothelial cells by the TUNEL method was found in phenol-treated lesions, but not in nontreated lesions.
  • [MeSH-major] Hemangiosarcoma / drug therapy. Hemangiosarcoma / pathology. Phenol / therapeutic use. Sclerosing Solutions / therapeutic use. Skin Neoplasms / drug therapy. Skin Neoplasms / pathology

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  • (PMID = 19416375.001).
  • [ISSN] 1365-4632
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Sclerosing Solutions; 339NCG44TV / Phenol
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26. Deyrup AT, McKenney JK, Tighiouart M, Folpe AL, Weiss SW: Sporadic cutaneous angiosarcomas: a proposal for risk stratification based on 69 cases. Am J Surg Pathol; 2008 Jan;32(1):72-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sporadic cutaneous angiosarcomas: a proposal for risk stratification based on 69 cases.
  • Angiosarcomas have traditionally been considered high-grade lesions for which histologic features and grading have played no role in prognostication and, consequently, they have been excluded from the American Joint Committee on Cancer staging system.
  • We have, therefore, analyzed 69 cutaneous angiosarcomas seen in consultation and not associated with lymphedema or prior radiation therapy to determine if a combination of histologic and clinical parameters could be used to differentiate indolent from aggressive tumors.
  • Forty-seven patients died (30 of disease) and 22 were alive at last known follow-up (range, 16 to 158 mo; mean, 65; median, 36).
  • Five-year disease-specific survival was 48%.
  • In conclusion, we report that a combination of clinical and histologic features allows stratification of angiosarcoma patients into 2 risk groups that are strongly associated with marked differences in clinical course.
  • [MeSH-major] Hemangiosarcoma / pathology. Skin Neoplasms / pathology

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  • (PMID = 18162773.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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27. Styring E, Fernebro J, Jönsson PE, Ehinger A, Engellau J, Rissler P, Rydholm A, Nilbert M, Vult von Steyern F: Changing clinical presentation of angiosarcomas after breast cancer: from late tumors in edematous arms to earlier tumors on the thoracic wall. Breast Cancer Res Treat; 2010 Aug;122(3):883-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Changing clinical presentation of angiosarcomas after breast cancer: from late tumors in edematous arms to earlier tumors on the thoracic wall.
  • Angiosarcoma is a rare complication of breast cancer treatment.
  • In order to define predictors, clinical presentation, and outcome, we characterized a population-based 50-year cohort of angiosarcomas after breast cancer.
  • Clinical data were collected from all females with previous breast cancer who developed angiosarcomas/lymphangiosarcomas on the thoracic wall/upper extremity between 1958 and 2008 in the Southern Swedish health care region.
  • In total, 31 angiosarcomas developed at a median age of 71 years.
  • The patients formed two distinct groups; 14 females treated for breast cancer with radical mastectomy and radiotherapy 1949-1988 developed angiosarcomas in edematous arms (Stewart-Treves syndrome) after median 11 years, and 17 females treated by segmental resection, anti-hormonal treatment and radiotherapy 1980-2005 developed angiosarcomas in the irradiated field on the thoracic wall after median 7.3 years.
  • In this population-based cohort, the early angiosarcomas developed in edematous arms after radical mastectomies, whereas more recent cases occurred after a shorter time period in the irradiated fields following breast conserving surgery.
  • We conclude that the clinical presentation of angiosarcomas has changed, parallel with altered treatment principles for breast cancer.
  • [MeSH-major] Arm. Breast Neoplasms / therapy. Edema / etiology. Hemangiosarcoma / etiology. Neoplasm Recurrence, Local / etiology. Neoplasms, Second Primary / etiology. Thoracic Wall / pathology

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  • (PMID = 20087653.001).
  • [ISSN] 1573-7217
  • [Journal-full-title] Breast cancer research and treatment
  • [ISO-abbreviation] Breast Cancer Res. Treat.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
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28. Weissferdt A, Kalhor N, Suster S, Moran CA: Primary angiosarcomas of the anterior mediastinum: a clinicopathologic and immunohistochemical study of 9 cases. Hum Pathol; 2010 Dec;41(12):1711-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary angiosarcomas of the anterior mediastinum: a clinicopathologic and immunohistochemical study of 9 cases.
  • We report 9 cases of primary angiosarcomas of the anterior mediastinum.
  • These were either lined by bland or more pleomorphic endothelial cells.
  • Follow-up information available for 6 patients revealed that 4 were alive and free of disease at intervals ranging from 6 to 36 months after diagnosis and 1 was alive with recurrence at 48 months.
  • One patient had died of the disease 10 months after diagnosis.
  • Primary angiosarcomas of the anterior mediastinum are rare tumors that need to be added to the differential diagnosis of primary anterior mediastinal neoplasms.
  • Despite their histologic similarity to angiosarcomas at other sites, primary angiosarcomas of the anterior mediastinum appear to follow a more protracted clinical course than their counterparts in other organ systems.
  • [MeSH-major] Hemangiosarcoma / pathology. Mediastinal Neoplasms / pathology. Mediastinum / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / metabolism. Combined Modality Therapy. Disease-Free Survival. Fatal Outcome. Female. Humans. Immunohistochemistry. Male. Middle Aged. Thymus Gland / pathology

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20709359.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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29. Itakura E, Yamamoto H, Oda Y, Tsuneyoshi M: Detection and characterization of vascular endothelial growth factors and their receptors in a series of angiosarcomas. J Surg Oncol; 2008 Jan 1;97(1):74-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Detection and characterization of vascular endothelial growth factors and their receptors in a series of angiosarcomas.
  • BACKGROUND: Angiosarcomas are malignant mesenchymal neoplasms, including sarcomas of presumptive vascular endothelial origin and sarcomas of probable lymphatic origin.
  • The majority of angiosarcomas are thought to originate from vascular endothelia and spread via bloodstream to lung, but lymphatic metastases can occur.
  • METHODS: We investigated immunohistochemical expression of vascular endothelial growth factors (VEGF-A, VEGF-C) and their receptors (VEGFR-1, VEGFR-2, VEGFR-3) in a series of 34 angiosarcomas.
  • CONCLUSIONS: VEGF-A and VEGFR-1 were detected in diverse subtypes of angiosarcomas.
  • In cooperation, VEGF-A and VEGF-C are likely to be involved in the development of angiosarcoma associated with lymphedema.
  • Angiosarcoma of the scalp, which is traditionally considered as a true hemangiosarcoma, may include some cases of lymphatic origin.
  • [MeSH-major] Hemangiosarcoma / chemistry. Receptors, Vascular Endothelial Growth Factor / analysis. Vascular Endothelial Growth Factor A / analysis

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  • [Copyright] (c) 2007 Wiley-Liss, Inc.
  • (PMID = 18041747.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Vascular Endothelial Growth Factor A; EC 2.7.10.1 / Receptors, Vascular Endothelial Growth Factor
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30. Patnaik A, Chiorean EG, Tolcher A, Papadopoulos K, Beeram M, Kee D, Waddell M, Gilles E, Buchbinder A: EZN-2968, a novel hypoxia-inducible factor-1α (HIF-1α) messenger ribonucleic acid (mRNA) antagonist: Results of a phase I, pharmacokinetic (PK), dose-escalation study of daily administration in patients (pts) with advanced malignancies. J Clin Oncol; 2009 May 20;27(15_suppl):2564

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Tumor types included colorectal cancer (7 pts); renal cancer (4 pts); soft-tissue sarcoma (STS; 2 pts); angiosarcoma (1 pt); melanoma (1 pt); and breast, ovarian, pancreatic, and prostate cancers (1 pt each).
  • Stable disease was observed for 1 pt with angiosarcoma (28 wks) and 1 pt with renal cancer (12 wks).
  • Durable stable disease has been observed.

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  • (PMID = 27961885.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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31. Yang XJ, Zheng JW, Zhou Q, Ye WM, Wang YA, Zhu HG, Wang LZ, Zhang ZY: Angiosarcomas of the head and neck: a clinico-immunohistochemical study of 8 consecutive patients. Int J Oral Maxillofac Surg; 2010 Jun;39(6):568-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcomas of the head and neck: a clinico-immunohistochemical study of 8 consecutive patients.
  • Angiosarcoma, also known as malignant hemangioendothelioma, is a rare and aggressive malignant vascular tumour arising from endothelial cells, which accounts for approximately 10% of soft tissue sarcomas in the head and neck.
  • Between October 1996 and July 2008, 10 patients were diagnosed with angiosarcomas (AS) in the head and neck region, 8 of whom were included in this study (there were 7 high-grade and 1 low-grade lesions).
  • Of the 8 patients reviewed in this study, 5 died of local recurrence or distant metastasis with a survival time of 8-19 months, 2 patients are alive with disease and 1 patient is free of disease.
  • [MeSH-major] Biomarkers, Tumor / analysis. Head and Neck Neoplasms / chemistry. Head and Neck Neoplasms / pathology. Hemangiosarcoma / chemistry. Hemangiosarcoma / pathology

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  • (PMID = 20413272.001).
  • [ISSN] 1399-0020
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Antigens, CD34; 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 9001-27-8 / Factor VIII
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32. Ahmad Z, Nisa A, Idrees R, Minhas K, Pervez S, Mumtaz K: Hepatic angiosarcoma with metastasis to small intestine. J Coll Physicians Surg Pak; 2008 Jan;18(1):50-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hepatic angiosarcoma with metastasis to small intestine.
  • Hepatic angiosarcomas are rare tumours with poor prognosis, with patients usually dying within 6 months.
  • Similarly, primary or metastatic angiosarcomas in small intestine are extremely rare, often present with recurrent gastrointestinal bleeding and anemia, and have an extremely poor prognosis.
  • Both primary or metastatic intestinal angiosarcomas may exhibit epithelioid morphology.
  • [MeSH-major] Hemangiosarcoma / pathology. Ileal Neoplasms / secondary. Intestine, Small / pathology. Jejunal Neoplasms / secondary. Liver Neoplasms / pathology

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  • (PMID = 18452671.001).
  • [ISSN] 1022-386X
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Pakistan
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33. Tokuyama W, Mikami T, Masuzawa M, Okayasu I: Autocrine and paracrine roles of VEGF/VEGFR-2 and VEGF-C/VEGFR-3 signaling in angiosarcomas of the scalp and face. Hum Pathol; 2010 Mar;41(3):407-14
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Autocrine and paracrine roles of VEGF/VEGFR-2 and VEGF-C/VEGFR-3 signaling in angiosarcomas of the scalp and face.
  • Angiosarcoma of the skin is an extremely rare malignant tumor of vascular origin that usually arises in the scalp and face of elderly persons.
  • To clarify its characteristic features and cell cycle kinetics, we quantitatively evaluated the expression of cell cycle-related molecules and vascular endothelial growth factors using immunohistochemical staining, for comparison with 2 benign vascular tumors of the skin, the capillary hemangioma and the cavernous hemangioma.
  • Cell proliferation, determined with reference to the Ki-67 labeling index, was highest in angiosarcomas and lowest in cavernous hemangiomas (angiosarcomas versus capillary hemangioma, P = .014; capillary hemangioma versus cavernous hemangiomas, P = 1.4 x 10(-4)).
  • Expressions of cyclin D1 and p16(INK4A) were also significantly higher in angiosarcoma than in cavernous hemangioma.
  • Expression levels of vascular endothelial growth factor and its receptor, VEGFR-2, were highest in angiosarcomas.
  • VEGF-C expression in angiosarcomas was significantly higher than in cavernous hemangiomas, and its receptor VEGFR-3 expression was highest in angiosarcomas.
  • [MeSH-major] Head and Neck Neoplasms / metabolism. Hemangiosarcoma / metabolism. Scalp / metabolism. Vascular Endothelial Growth Factor A / metabolism. Vascular Endothelial Growth Factor C / metabolism. Vascular Endothelial Growth Factor Receptor-2 / metabolism. Vascular Endothelial Growth Factor Receptor-3 / metabolism

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 19913279.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclin A; 0 / Cyclin E; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Ki-67 Antigen; 0 / Vascular Endothelial Growth Factor A; 0 / Vascular Endothelial Growth Factor C; EC 2.7.10.1 / Vascular Endothelial Growth Factor Receptor-2; EC 2.7.10.1 / Vascular Endothelial Growth Factor Receptor-3
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34. West J, Liao SY, Cho D: Angiosarcoma after breast conservation: diagnostic pitfalls. Clin Breast Cancer; 2008 Feb;8(1):94-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma after breast conservation: diagnostic pitfalls.
  • Angiosarcomas are aggressive tumors of endovascular origin.
  • Although angiosarcomas are relatively rare, they are being reported with increasing frequency in patients who have previously undergone breast conserving therapy.
  • The initial clinical presentation of angiosarcomas after breast irradiation is often similar to the presentation of recurrent breast carcinomas.
  • In addition, the histologic and cytologic appearance of posttreatment angiosarcomas can be highly suggestive of recurrent breast carcinoma.
  • An accurate diagnosis is essential, because prognosis and treatment are different for each condition.
  • An early and accurate diagnosis is aided by a high index of suspicion by clinician and pathologist.
  • Herein, a case history is presented that underscores the pitfalls in attempting to achieve an accurate diagnosis.
  • [MeSH-major] Breast Neoplasms / surgery. Hemangiosarcoma / pathology. Neoplasms, Second Primary / pathology
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Mastectomy, Segmental. Middle Aged

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  • (PMID = 18501065.001).
  • [ISSN] 1526-8209
  • [Journal-full-title] Clinical breast cancer
  • [ISO-abbreviation] Clin. Breast Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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35. Carnero López B, Fernández Pérez I, Carrasco Alvarez JA, Lázaro Quintela ME, López Jato C, Jorge Fernández M, Gentil González M, Vázquez Tuñas L, Castellanos Díez J: Renal primary angiosarcoma. Clin Transl Oncol; 2007 Dec;9(12):806-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Renal primary angiosarcoma.
  • Angiosarcomas account for 2% of all soft tissue sarcomas and of them, primary renal angiosarcomas represent 1%.
  • We report the second case to be described in a middle-aged female, with pulmonary metastases at diagnosis, and fatal outcome despite surgery and chemotherapy.
  • [MeSH-major] Hemangiosarcoma / pathology. Kidney Neoplasms / pathology

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  • (PMID = 18158986.001).
  • [ISSN] 1699-048X
  • [Journal-full-title] Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
  • [ISO-abbreviation] Clin Transl Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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36. Zhou ML, Yan FH, Ye F, Xiong Z, Wang JH, Ji Y: [Images of primary hepatic angiosarcomas]. Zhonghua Gan Zang Bing Za Zhi; 2008 Feb;16(2):136-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Images of primary hepatic angiosarcomas].
  • [MeSH-major] Hemangiosarcoma / radiography. Liver Neoplasms / radiography. Tomography, X-Ray Computed

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  • (PMID = 18304433.001).
  • [ISSN] 1007-3418
  • [Journal-full-title] Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology
  • [ISO-abbreviation] Zhonghua Gan Zang Bing Za Zhi
  • [Language] chi
  • [Publication-type] Journal Article
  • [Publication-country] China
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37. Young RJ, Brown NJ, Reed MW, Hughes D, Woll PJ: Angiosarcoma. Lancet Oncol; 2010 Oct;11(10):983-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma.
  • Angiosarcomas are rare soft-tissue sarcomas of endothelial cell origin that have a poor prognosis.
  • They can arise anywhere in the body, most commonly presenting as cutaneous disease in elderly white men, involving the head and neck and particularly the scalp.
  • They can be caused by therapeutic radiation or chronic lymphoedema and hence secondary breast angiosarcomas are an important subgroup.
  • Recent work has sought to establish the molecular biology of angiosarcomas and identify specific targets for treatment.
  • Interest is now focused on trials of vascular-targeted drugs, which are showing promise in the control of angiosarcomas.
  • In this review we discuss angiosarcoma and its current management, with a focus on clinical trials investigating the treatment of advanced disease.
  • [MeSH-major] Hemangiosarcoma / therapy
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Male. Neoplasm Staging. Predictive Value of Tests. Risk Factors. Treatment Outcome

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  • [Copyright] Copyright © 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20537949.001).
  • [ISSN] 1474-5488
  • [Journal-full-title] The Lancet. Oncology
  • [ISO-abbreviation] Lancet Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
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38. Glazebrook KN, Magut MJ, Reynolds C: Angiosarcoma of the breast. AJR Am J Roentgenol; 2008 Feb;190(2):533-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma of the breast.
  • OBJECTIVE: This article describes the imaging findings, pathologic correlation, and clinical presentation of rare primary and secondary angiosarcomas of the breast.
  • CONCLUSION: With the increasing use of breast conservation therapy for breast cancer, reports of postirradiation angiosarcoma have increased.
  • Both primary and secondary angiosarcomas may present with bruiselike skin discoloration, which may delay the diagnosis.
  • [MeSH-major] Breast Neoplasms / diagnosis. Diagnostic Imaging / methods. Hemangiosarcoma / diagnosis. Image Enhancement / methods

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  • (PMID = 18212243.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 18
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39. Domfeh AB, Fichera M, Hunt JL: Allelic loss of 3 different tumor suppressor gene loci in benign and malignant endothelial tumors of the head and neck. Arch Pathol Lab Med; 2006 Aug;130(8):1184-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Allelic loss of 3 different tumor suppressor gene loci in benign and malignant endothelial tumors of the head and neck.
  • CONTEXT: Angiosarcomas are rare malignancies that commonly arise in the head and neck.
  • No definitive precursor lesion or etiological link between hemangiomas and angiosarcoma has been postulated.
  • Evidence at the cell culture level suggests that loss of heterozygosity of 13q might be involved in tumorigenesis of endothelial cells.
  • Although overexpression of p53 and WT-1 has been found in angiosarcoma, little is known about the molecular changes involved.
  • OBJECTIVE: This study compared the molecular profile of angiosarcoma with that in some benign vascular lesions.
  • DESIGN: Specimens from 6 cases of angiosarcoma, 5 of hemangioma, and 5 of granulation tissue were microdissected.
  • RESULTS: The mean fractional allelic loss was 43% for angiosarcomas and 29% for hemangiomas.
  • Eighty-three percent of angiosarcomas had allelic loss at 17p13, 66% at 13q14, and 50% at 11p13.
  • CONCLUSIONS: In our study, 11p13, 13q14, and 17p13 allelic losses were present in both hemangiomas and angiosarcomas.
  • This supports the cell culture-based theories that tumorigenesis in endothelial cells likely involves these chromosomes and provides some insight into the potential pathogenesis of angiosarcomas and benign hemangiomas.
  • [MeSH-major] Genes, Tumor Suppressor. Head and Neck Neoplasms / genetics. Hemangioma / genetics. Hemangiosarcoma / genetics. Loss of Heterozygosity / genetics

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  • (PMID = 16879020.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / Genetic Markers
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40. Carillo GA, Carretero MA, Vazquez JE, Fontan EG, Ramos MB, Ventura JA, Rodriguez AP, Salmon AS, Tejedor JL: Epithelioid angiosarcoma of the lung with pleural metastases: a rare cause of haemoptysis clinicopathological conference. Heart Lung Circ; 2010 Oct;19(10):624-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epithelioid angiosarcoma of the lung with pleural metastases: a rare cause of haemoptysis clinicopathological conference.
  • Angiosarcomas are a rare type of malignant vascular tumour characterised by proliferation of tumour cells with vascular endothelial features.
  • Pulmonary angiosarcomas are usually secondary tumours, and only a few primary cases have been reported.
  • We present a case of a 56 year-old male with persistent haemoptysis secondary to lung epithelioid angiosarcoma with pleural metastases.
  • [MeSH-major] Hemangiosarcoma / pathology. Hemoptysis / etiology. Lung Neoplasms / pathology. Pleural Neoplasms / secondary

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  • [Copyright] Copyright © 2010 Australasian Society of Cardiac and Thoracic Surgeons and the Cardiac Society of Australia and New Zealand. Published by Elsevier B.V. All rights reserved.
  • (PMID = 20541463.001).
  • [ISSN] 1444-2892
  • [Journal-full-title] Heart, lung & circulation
  • [ISO-abbreviation] Heart Lung Circ
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Coloring Agents; YKM8PY2Z55 / Hematoxylin
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41. Namysłowski G, Scierski W, Turecka L, Urbaniec N, Lange D: [A very rare case of low-grade angiosarcoma of the nose and paranasal sinuses]. Otolaryngol Pol; 2005;59(1):105-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A very rare case of low-grade angiosarcoma of the nose and paranasal sinuses].
  • Angiosarcomas of the nose and paranasal sinuses are extremely rare.
  • Histologically angiosarcomas are divided into two groups: low and high-grade.
  • We present a case of angiosarcoma of apparent low-grade malignancy localized within the nasal cavity and paranasal sinuses in a 74-year old woman treated by radiotherapy due to middle ear chemodectoma 21 years ago.
  • [MeSH-major] Hemangiosarcoma. Nose Neoplasms. Paranasal Sinus Neoplasms

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  • (PMID = 15915928.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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42. Altan E, Arslan C, Dede D, Dogan E, Altundag K: Primary Angiosarcoma of the Breast after Pregnancy. Am Surg; 2010 Aug 01;76(8):115

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary Angiosarcoma of the Breast after Pregnancy.

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  • (PMID = 28958226.001).
  • [ISSN] 1555-9823
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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43. Costantini R, Di Bartolomeo N, Francomano F, Angelucci D, Innocenti P: Epithelioid angiosarcoma of the gallbladder: case report. J Gastrointest Surg; 2005 Jul-Aug;9(6):822-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epithelioid angiosarcoma of the gallbladder: case report.
  • A patient with epithelioid angiosarcoma of the gallbladder is described.
  • Pathophysiological, clinical, and therapeutic aspects are discussed in relation to the available data on angiosarcomas of the gallbladder.
  • [MeSH-major] Cholecystectomy / methods. Gallbladder Neoplasms / pathology. Gallbladder Neoplasms / surgery. Hemangiosarcoma / secondary. Hemangiosarcoma / surgery. Liver Neoplasms / secondary

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  • (PMID = 15985238.001).
  • [ISSN] 1091-255X
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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44. Kim SM, Kim HH, Shin HJ, Gong G, Ahn SH: Cavernous haemangioma of the breast. Br J Radiol; 2006 Nov;79(947):e177-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Vascular tumours of the breast are rare and most can be classified as either angiosarcomas or haemangiomas.
  • [MeSH-major] Breast Neoplasms / diagnosis. Calcinosis / diagnosis. Hemangioma, Cavernous / diagnosis

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  • (PMID = 17065282.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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45. Pohar-Marinsek Z, Lamovec J: Angiosarcoma in FNA smears: diagnostic accuracy, morphology, immunocytochemistry and differential diagnoses. Cytopathology; 2010 Oct;21(5):311-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma in FNA smears: diagnostic accuracy, morphology, immunocytochemistry and differential diagnoses.
  • OBJECTIVE: The aim of our study was to analyse the diagnostic accuracy in recognizing angiosarcoma from fine needle aspiration (FNA) samples and to determine morphological features of angiosarcoma in cytology.
  • METHODS: FNA samples from 18 histologically confirmed angiosarcomas obtained between 1985 and 2009 were included in the study.
  • RESULTS: There were 13 primary angiosarcomas and five recurrent tumours; nine tumours were epithelioid.
  • Twelve tumours were cytologically diagnosed as malignant, three as suspicious and three were judged unsatisfactory.
  • Cytomorphology did not correlate well with histology in mixed and spindle cell types of angiosarcomas.
  • Immunocytochemistry was applied in seven cases, specific vascular marker CD31 only twice at the time of diagnosis and three times retrospectively.
  • CONCLUSIONS: Angiosarcomas are difficult to recognize on FNA smears when they lack the typical dual, spindle and epithelioid cell population and when they occur in internal organs where carcinomas are more common.
  • [MeSH-major] Hemangiosarcoma / pathology
  • [MeSH-minor] Adult. Aged. Antigens, CD31. Biomarkers, Tumor / metabolism. Biopsy, Fine-Needle. Cytodiagnosis. Diagnosis, Differential. Diagnostic Errors. Epithelioid Cells / metabolism. Epithelioid Cells / pathology. Female. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Recurrence, Local. Reproducibility of Results

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  • (PMID = 20105214.001).
  • [ISSN] 1365-2303
  • [Journal-full-title] Cytopathology : official journal of the British Society for Clinical Cytology
  • [ISO-abbreviation] Cytopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Biomarkers, Tumor
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46. Ayadi L, Khabir A: Pediatric angiosarcoma of soft tissue: a rare clinicopathologic entity. Arch Pathol Lab Med; 2010 Mar;134(3):481-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pediatric angiosarcoma of soft tissue: a rare clinicopathologic entity.
  • Angiosarcomas are rare tumors that predominantly affect adults and elderly patients.
  • Although angiosarcomas are well described in a variety of clinical settings, they have been poorly studied in children and little is known about their biology, natural history, or optimal treatment.
  • Childhood angiosarcomas are exceedingly rare.
  • The differential diagnosis includes Kaposi sarcoma, epithelioid hemangioendothelioma, hemangiopericytoma, and spindle cell hemangioendothelioma whose prognosis is different.
  • Malignant vascular tumors are rare in children in the first 2 decades of life and when they do occur they seem to be more aggressive than in adults.
  • Pathologic diagnosis is difficult particularly in poorly differentiated angiosarcomas requiring immunohistochemical study to confirm vascular differentiation.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Hemangiosarcoma / pathology. Mediastinal Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adolescent. Biomarkers, Tumor / analysis. Child. Child, Preschool. Combined Modality Therapy. Diagnosis, Differential. Female. Hemangioendothelioma, Epithelioid / diagnosis. Hemangiopericytoma / diagnosis. Humans. Infant. Male. Prognosis. Sarcoma, Kaposi / diagnosis

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  • (PMID = 20196675.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 17
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47. Keenan N, Davies S, Sheppard MN, Maceira A, Serino W, Mohiaddin RH: Angiosarcoma of the right atrium: a diagnostic dilemma. Int J Cardiol; 2006 Nov 18;113(3):425-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma of the right atrium: a diagnostic dilemma.
  • Angiosarcomas of the heart are rare and usually fatal.
  • We describe a case where cardiovascular magnetic resonance imaging was crucial in making the diagnosis.
  • Surgical resection was performed and the diagnosis was confirmed by histology.
  • [MeSH-major] Heart Atria. Heart Neoplasms / diagnosis. Hemangiosarcoma / diagnosis. Magnetic Resonance Imaging

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  • (PMID = 16310265.001).
  • [ISSN] 1874-1754
  • [Journal-full-title] International journal of cardiology
  • [ISO-abbreviation] Int. J. Cardiol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Netherlands
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48. Seethala RR, Gomez JA, Vakar-Lopez F: Primary angiosarcoma of the bladder. Arch Pathol Lab Med; 2006 Oct;130(10):1543-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary angiosarcoma of the bladder.
  • CONTEXT: Primary bladder angiosarcomas are extremely rare, and their clinical and pathologic features are not well described.
  • OBJECTIVE: To further refine the clinical features of primary bladder angiosarcomas and define their pathologic spectra.
  • STUDY SELECTION: After excluding 4 cases that likely secondarily involved the bladder, we identified 9 true primary bladder angiosarcomas.
  • DATA SYNTHESIS: Primary bladder angiosarcomas were found at a mean age of 64.2 years, with a male-female ratio of 8:1.
  • Primary bladder angiosarcomas typically presented with hematuria and were grossly hemorrhagic, raised masses (mean size, 6.7 cm) of the trigone and/or dome.
  • Three (43%) of 7 patients died within a year, but only 1 patient died with evidence of disease.
  • CONCLUSIONS: Primary angiosarcomas of the bladder are typically rare tumors of middle-aged and elderly men that present with locally advanced disease and show a wide histologic spectrum.
  • [MeSH-major] Hemangiosarcoma / complications. Hemangiosarcoma / pathology. Hematuria / etiology. Hemorrhage / etiology. Urinary Bladder / blood supply. Urinary Bladder Neoplasms / complications. Urinary Bladder Neoplasms / pathology

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  • (PMID = 17090199.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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49. Armah HB, Rao UN, Parwani AV: Primary angiosarcoma of the testis: report of a rare entity and review of the literature. Diagn Pathol; 2007;2:23
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary angiosarcoma of the testis: report of a rare entity and review of the literature.
  • BACKGROUND: Primary testicular angiosarcomas are extremely rare, and their clinicopathologic features are not well described.
  • Our objective was to further define the clinical features and pathologic spectra of primary testicular angiosarcomas.
  • After excluding 2 cases because they did not involve the testis, we identified 4 previously reported cases of true primary testicular angiosarcoma.
  • We also searched the electronic medical archival records of our institution and identified one additional unreported case of true primary testicular angiosarcomas.
  • Data were extracted on the demographics, predisposing factors, clinical presentation, gross pathology, microscopic pathology, immunophenotype, therapy, and outcomes of each of these 5 cases of true primary testicular angiosarcomas.
  • RESULTS: Primary testicular angiosarcomas were found at a mean age of 43.4 years.
  • One patient had multiple metastatic recurrences but eventual outcome was not available, and 1 patient died a month after diagnosis from stroke but no autopsy was performed.
  • CONCLUSION: Primary testicular angiosarcomas are typically rare tumors of men of all ages that appear to segregate into 2 groups; one associated with teratoma and occurring in young people, and the other occurring in the elderly and not associated with germ cell neoplasm, but may be associated with chronic hydrocele.
  • They present with advanced disease and show a wide histologic spectrum.

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  • (PMID = 17601346.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1919353
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50. Dunlap JB, Magenis RE, Davis C, Himoe E, Mansoor A: Cytogenetic analysis of a primary bone angiosarcoma. Cancer Genet Cytogenet; 2009 Oct;194(1):1-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytogenetic analysis of a primary bone angiosarcoma.
  • Primary bone angiosarcomas are rare and aggressive vascular malignancies with a high mortality rate.
  • To our knowledge, there are no reported cytogenetic abnormalities in primary bone angiosarcomas, although several have been reported in soft tissue angiosarcomas.
  • We report a case of primary bone angiosarcoma, arising in the tibia of a 79-year-old woman, with a unique clonal chromosomal rearrangement: t(1;14)(p21;q24), that has not been reported in either soft tissue or primary bone angiosarcoma.
  • [MeSH-major] Bone Neoplasms / genetics. Hemangiosarcoma / genetics. Translocation, Genetic

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  • (PMID = 19737647.001).
  • [ISSN] 1873-4456
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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51. Castro EC, Galambos C, Shaw PH, Ranganathan S: Primary mesenteric angiosarcoma in a child with associated lymphangiectasia: a case report. Pediatr Dev Pathol; 2008 Nov-Dec;11(6):482-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary mesenteric angiosarcoma in a child with associated lymphangiectasia: a case report.
  • Angiosarcomas are rare tumors in children, usually occurring in soft tissue and liver.
  • By contrast, angiosarcoma in adults usually occurs in the extremities in conjunction with lymphedema.
  • Mesenteric angiosarcoma has only rarely been reported.
  • When angiosarcomas arise in this location, they usually represent a 2nd malignancy following Hodgkin's lymphoma.
  • We report a child who presented to the emergency room with an acute abdomen and underwent emergency surgery for a mesenteric angiosarcoma with associated lymphangiectasia of the bowel and mesentery.
  • [MeSH-major] Hemangiosarcoma / secondary. Lymphangiectasis, Intestinal / pathology. Peritoneal Neoplasms / pathology

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  • (PMID = 19143455.001).
  • [ISSN] 1093-5266
  • [Journal-full-title] Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
  • [ISO-abbreviation] Pediatr. Dev. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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52. Karamlou T, Li MK, Williamson WK, Heller L, Wiest JW: Angiosarcoma of the thoracoabdominal aorta presenting with systemic hypertension, anemia, and visceral ischemia. Ann Vasc Surg; 2008 May-Jun;22(3):459-64
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma of the thoracoabdominal aorta presenting with systemic hypertension, anemia, and visceral ischemia.
  • Aortic angiosarcomas, one of the three major types of primary aortic tumors, are exceedingly rare, with only 25 cases reported in the literature.
  • Peripheral thromboembolic complications are the most frequently described presenting feature, and therefore, these tumors can be mistaken for aortoiliac occlusive disease.
  • We describe a rare case of an extensive thoracoabdominal angiosarcoma that manifested with hypertension, profound anemia, and visceral ischemia in a young woman.
  • [MeSH-major] Anemia / etiology. Aorta, Thoracic / pathology. Hemangiosarcoma / diagnosis. Hypertension / etiology. Ischemia / etiology. Vascular Neoplasms / diagnosis. Viscera / blood supply

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  • (PMID = 18367372.001).
  • [ISSN] 1615-5947
  • [Journal-full-title] Annals of vascular surgery
  • [ISO-abbreviation] Ann Vasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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53. Mignogna C, Simonetti S, Galloro G, Magno L, De Cecio R, Insabato L: Duodenal epithelioid angiosarcoma: immunohistochemical and clinical findings. A case report. Tumori; 2007 Nov-Dec;93(6):619-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Duodenal epithelioid angiosarcoma: immunohistochemical and clinical findings. A case report.
  • Angiosarcomas are uncommon malignant tumors of vascular endothelium that represent less than 1% of all sarcomas.
  • The epithelioid variant of angiosarcomas is exceptionally rare, and the gastrointestinal tract is rarely involved.
  • Angiosarcomas mainly involve skin and soft tissue and rarely occur in breast, liver, bone, and spleen.
  • A duodenal reddish polypoid lesion was found, which on microscopic examination turned out to be an epithelioid angiosarcoma.
  • The immunohistochemical features of the lesion supported this diagnosis.
  • The patient died eight months after the diagnosis.
  • Epithelioid angiosarcoma is an aggressive variant of angiosarcoma and must be considered in the differential diagnosis of gastrointestinal tumors.
  • [MeSH-major] Duodenal Neoplasms / pathology. Hemangioendothelioma, Epithelioid / pathology. Hemangiosarcoma / pathology

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  • (PMID = 18338501.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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54. Treviño-González JL, Santos-Lartigue R, González-Andrade B, Villagomez-Ortiz VJ, Villegas M, Venegas-García EM: Angiosarcoma of the nasal cavity: a case report. Cases J; 2009;2(1):104

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma of the nasal cavity: a case report.
  • Angiosarcomas are malignant neoplasias of rapid growth that develop from endothelial cells.
  • They represent 2% of all sarcomas and only 1-4% are located in the aerodigestive tract.
  • A biopsy revealed an intermediate-grade angiosarcoma.
  • Aerodigestive angiosarcomas have a better prognosis than angiosarcomas of other locations due to better cell differentiation and the presence of early symptoms.

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  • (PMID = 19178724.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
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55. Dehqanzada ZA, Menezes G, Mukherjee D: Epithelioid angiosarcoma of the aorta in a 47-year-old man: a case report and literature review. J Surg Educ; 2007 May-Jun;64(3):165-70

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epithelioid angiosarcoma of the aorta in a 47-year-old man: a case report and literature review.
  • Epithelioid angiosarcomas of the aorta are extremely rare neoplasms with only 26 previous reports in the literature.
  • An extremely unusual case is reported of an aortic epithelioid angiosarcoma diagnosed in a 47-year-old man who was being evaluated for his rectal adenocarcinoma.
  • No previous reports of a synchronous aortic angiosarcomas and adenocarcinomas of the colorectum have been reported.
  • Even though the occurrence of the aortic intimal neoplasia and rectal cancer in this patient is most likely coincidental, the onset of this disease in a young man without risk factors for either disease probably suggests a genetic basis of his disease.
  • [MeSH-major] Adenocarcinoma / pathology. Aortic Diseases / pathology. Hemangiosarcoma / pathology. Rectal Neoplasms / pathology

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  • (PMID = 17574179.001).
  • [ISSN] 1931-7204
  • [Journal-full-title] Journal of surgical education
  • [ISO-abbreviation] J Surg Educ
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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56. Chen X, Mitsutake N, LaPerle K, Akeno N, Zanzonico P, Longo VA, Mitsutake S, Kimura ET, Geiger H, Santos E, Wendel HG, Franco A, Knauf JA, Fagin JA: Endogenous expression of Hras(G12V) induces developmental defects and neoplasms with copy number imbalances of the oncogene. Proc Natl Acad Sci U S A; 2009 May 12;106(19):7979-84
SciCrunch. Marmoset Gene list: Data: Gene Annotation .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • These mice developed papillomas and angiosarcomas, which were associated with Hras(G12V) allelic imbalance and augmented Hras signaling.
  • Tumor initiation by Hras(G12V) likely requires augmentation of signal output, which in papillomas and angiosarcomas is achieved via increased Hras-gene copy number, which may be favored by a higher mutation frequency in cells expressing the oncoprotein.

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  • (PMID = 19416908.001).
  • [ISSN] 1091-6490
  • [Journal-full-title] Proceedings of the National Academy of Sciences of the United States of America
  • [ISO-abbreviation] Proc. Natl. Acad. Sci. U.S.A.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA072597; United States / NCI NIH HHS / CA / R01 CA050706; United States / NCI NIH HHS / CA / P30 CA08748; United States / NIDDK NIH HHS / DK / T32 DK07313; United States / NCI NIH HHS / CA / CA72597; United States / NCI NIH HHS / CA / P30 CA008748; United States / NCI NIH HHS / CA / CA50706; United States / NIDDK NIH HHS / DK / T32 DK007313; United States / NCI NIH HHS / CA / R24 CA83084; United States / NCI NIH HHS / CA / R24 CA083084
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.6.5.2 / ras Proteins
  • [Other-IDs] NLM/ PMC2674938
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57. Bhardwaj M, Gautam RK, Sharma PK, Kar HK, Magoon N, Sharma A: Angiosarcoma of scalp: a case report. Indian J Pathol Microbiol; 2005 Oct;48(4):497-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma of scalp: a case report.
  • Cutaneous angiosarcomas are rare and constitute less than 1% of all malignant mesenchymal tumours.
  • Most angiosarcomas of skin arise in the following clinical settings: 1. face and scalp of elderly 2. following lymphoedema and 3. post radiation.
  • Histological examination of the biopsy revealed features of an angiosarcoma, which showed imunohistochemical positivity for factor VIII related antigen.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Hemangiosarcoma / pathology. Scalp. Skin Neoplasms / pathology

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  • (PMID = 16366109.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / von Willebrand Factor
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58. Uchiyama Y, Murakami S, Kishino M, Furukawa S: A case report of primary gingival angiosarcoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2009 Dec;108(6):e17-21

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case report of primary gingival angiosarcoma.
  • Angiosarcoma is a rare malignant neoplasm and primary angiosarcoma is extremely rare.
  • This study reports clinico-pathological features and CT image finding of a case of primary angiosarcoma in the upper gingival and a review of previously reported cases of primary gingival angiosarcomas including the present case.
  • [MeSH-major] Gingival Neoplasms / pathology. Hemangiosarcoma / pathology. Maxillary Neoplasms / pathology

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  • (PMID = 19913715.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Interleukin-2; 0 / Recombinant Proteins
  • [Number-of-references] 12
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59. Bhattacharya P, Singh P, Bahal A, Gulati D, Tevatia MS, Mehta A, Muttagikar MP: Angiosarcoma of pericardium: a report of two cases. Indian J Pathol Microbiol; 2007 Oct;50(4):777-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma of pericardium: a report of two cases.
  • Angiosarcomas are uncommon malignant neoplasms characterized by rapidly proliferating extensively infiltrating anaplastic cells derived from blood vessels and lining irregular, blood-filled spaces.
  • Here we present two cases of pericardial angiosarcoma, one of them showing widespread dissemination, which caused considerable diagnostic dilemma and the diagnosis could only be established very late in their course of disease.
  • [MeSH-major] Hemangiosarcoma / diagnosis. Hemangiosarcoma / pathology. Pericardium / pathology
  • [MeSH-minor] Adult. Fatal Outcome. Humans. Male. Middle Aged. Neoplasm Metastasis / diagnosis. Neoplasm Metastasis / pathology

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  • (PMID = 18306551.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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60. Mano MS, Fraser G, Kerr J, Gray M, Evans V, Kazmi A, Canney P: Radiation-induced angiosarcoma of the breast shows major response to docetaxel after failure of anthracycline-based chemotherapy. Breast; 2006 Feb;15(1):117-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Radiation-induced angiosarcoma of the breast shows major response to docetaxel after failure of anthracycline-based chemotherapy.
  • We report on the case of a patient with a diagnosis of an uncommon breast tumour, namely a radiation-induced angiosarcoma, which was primarily refractory to anthracycline-based chemotherapy, but highly sensitive to docetaxel.
  • Although the sarcomas in general tend to be relatively refractory to taxanes, there is some evidence that the angiosarcomas may be sensitive to these agents.
  • [MeSH-major] Antineoplastic Agents, Phytogenic / therapeutic use. Breast Neoplasms / drug therapy. Breast Neoplasms / etiology. Hemangiosarcoma / drug therapy. Hemangiosarcoma / etiology. Neoplasms, Radiation-Induced / drug therapy. Taxoids / therapeutic use

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  • Hazardous Substances Data Bank. DOCETAXEL .
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  • (PMID = 16473744.001).
  • [ISSN] 0960-9776
  • [Journal-full-title] Breast (Edinburgh, Scotland)
  • [ISO-abbreviation] Breast
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; 0 / Taxoids; 15H5577CQD / docetaxel; 3Z8479ZZ5X / Epirubicin; 8N3DW7272P / Cyclophosphamide; U3P01618RT / Fluorouracil
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61. Yoo C, Kim JE, Yoon SK, Kim SC, Ahn JH, Kim TW, Suh C, Lee JL: Angiosarcoma of the retroperitoneum: report on a patient treated with sunitinib. Sarcoma; 2009;2009:360875

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma of the retroperitoneum: report on a patient treated with sunitinib.
  • A 52 year-old woman presented with an incidentally detected retroperitoneal angiosarcoma and multiple hepatic metastases.
  • After chemotherapy with weekly paclitaxel and doxorubicin, angiosarcoma had progressed rapidly.
  • With this case report, we suggest sunitinib may be effective against angiosarcomas.
  • When sunitinib is administered to patients with angiosarcomas, hematologic abnormalities should be monitored frequently as severe hematologic toxicity may be caused either by sunitinib per se or angiosarcoma.

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  • (PMID = 19478954.001).
  • [ISSN] 1357-714X
  • [Journal-full-title] Sarcoma
  • [ISO-abbreviation] Sarcoma
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC2685913
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62. Dhawan SS, Raza M: Spindle cell hemangioendothelioma. Cutis; 2007 Feb;79(2):125-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spindle cell hemangioendothelioma.
  • Prior to the 1980s, the term hemangioendothelioma (HE) loosely applied to a spectrum of vascular tumors ranging from benign tumors, such as capillary hemangiomas, to fully malignant angiosarcomas.
  • In the early 1980s, the term epithelioid HE was used to describe a heterogeneous group of vascular tumors with an intermediate clinical course between hemangiomas and conventional angiosarcomas, thereby bringing to notice the borderline nature of these tumors.
  • [MeSH-major] Hemangioendothelioma / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 17388212.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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63. Verge J, Albiol J, Navas M, Martín C: [Primary angiosarcoma of the spleen with liver metastases. Case report and literature review]. Cir Esp; 2005 Jul;78(1):50-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Primary angiosarcoma of the spleen with liver metastases. Case report and literature review].
  • [Transliterated title] Angiosarcoma primario de bazo con metástasis hepáticas: presentación de un caso y revisión de la bibliografía.
  • Angiosarcomas of the spleen are infrequent tumors that often present with liver metastases.
  • Immunohistochemical markers can aid preoperative diagnosis since radiological and ultrasonographic images are fairly nonspecific.
  • [MeSH-major] Hemangiosarcoma / secondary. Hemangiosarcoma / surgery. Liver Neoplasms / secondary. Liver Neoplasms / surgery. Splenic Neoplasms / pathology. Splenic Neoplasms / surgery

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  • (PMID = 16420791.001).
  • [ISSN] 0009-739X
  • [Journal-full-title] Cirugía española
  • [ISO-abbreviation] Cir Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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64. Virtanen A, Pukkala E, Auvinen A: Angiosarcoma after radiotherapy: a cohort study of 332,163 Finnish cancer patients. Br J Cancer; 2007 Jul 2;97(1):115-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma after radiotherapy: a cohort study of 332,163 Finnish cancer patients.
  • We evaluated the risk of angiosarcoma after radiotherapy among all patients with cancers of breast, cervix uteri, corpus uteri, lung, ovary, prostate, or rectum, and lymphoma diagnosed in Finland during 1953-2003, identified from the Finnish Cancer Registry.
  • Only angiosarcomas of the trunk were considered, this being the target of radiotherapy for the first cancer.
  • In the follow-up of 1.8 million person-years at risk, 19 angiosarcomas developed, all after breast and gynaecological cancer.
  • Excess of angiosarcomas over national incidence rates were observed after radiotherapy without chemotherapy (standardised incidence ratio (SIR) 6.0, 95% confidence interval (CI) 2.7-11), after both radiotherapy and chemotherapy (SIR 100, 95% CI 12-360), and after other treatments (SIR 3.6, 95% CI 1.6-7.1).
  • Although an increased risk of angiosarcoma among cancer patients is evident, especially with breast and gynaecological cancer, the excess does not appear to be strongly related to radiotherapy.
  • [MeSH-major] Hemangiosarcoma / epidemiology. Neoplasms / radiotherapy. Neoplasms, Radiation-Induced / epidemiology. Neoplasms, Second Primary / epidemiology. Radiotherapy / adverse effects

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  • (PMID = 17519906.001).
  • [ISSN] 0007-0920
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2359658
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65. Schmid H, Zietz C: Human herpesvirus 8 and angiosarcoma: analysis of 40 cases and review of the literature. Pathology; 2005 Aug;37(4):284-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Human herpesvirus 8 and angiosarcoma: analysis of 40 cases and review of the literature.
  • AIMS: To prove a possible involvement of the endotheliotropic human herpesvirus 8 (HHV-8) in the pathogenesis of angiosarcoma in samples from patients in a low HHV-8 seroprevalence area.
  • METHODS: A comprehensive series of angiosarcomas (n = 40) as well as positive and negative control tissues from patients with Kaposi's sarcoma, human immunodeficiency virus (HIV)-associated multicentric Castleman's disease or juvenile haemangioma, respectively, was analysed with two sensitive methods: immunohistochemical staining for the HHV-8 latency-associated nuclear antigen 1 (LANA-1); and polymerase chain reaction (PCR) for HHV-8 VP23 DNA sequences.
  • RESULTS: None of the angiosarcoma cases and none of the negative control samples (juvenile haemangiomas) revealed positive immunohistochemical staining with the LANA-1 antibody.
  • In contrast, HHV-8 LANA-1 was clearly detected in all analysed cases of Kaposi's sarcoma and multicentric Castleman's disease.
  • CONCLUSION: In conclusion, the great majority of angiosarcomas investigated to date, including the series of 40 angiosarcomas analysed here, does not contain HHV-8 DNA sequences or protein.
  • This argues against a relevant role of the endotheliotropic HHV-8 in the pathogenesis of angiosarcoma and, for vascular diseases, speaks in favour of a relatively restricted pathogenic role of HHV-8 to Kaposi's sarcoma and multicentric Castleman's disease.
  • [MeSH-major] Hemangiosarcoma / virology. Herpesviridae Infections / epidemiology. Herpesvirus 8, Human / isolation & purification. Tumor Virus Infections / epidemiology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Animals. Female. Giant Lymph Node Hyperplasia / virology. Humans. Immunohistochemistry. Male. Middle Aged. Oncogenic Viruses / isolation & purification. Polymerase Chain Reaction. Sarcoma, Kaposi / virology

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  • (PMID = 16194826.001).
  • [ISSN] 0031-3025
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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66. Hayn MH, Bastacky S, Franks ME: Epididymal angiosarcoma. Urology; 2007 Mar;69(3):576.e5-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epididymal angiosarcoma.
  • Sarcomas are rare and account for approximately 1% of all malignancies.
  • The subtype angiosarcoma is derived from vascular and lymphatic tissue and generally has a poor prognosis.
  • Prior radiation therapy is a known risk factor for the development of angiosarcomas.
  • We present what we believe to be the first case of an angiosarcoma arising in the epididymis in an 80-year-old man who presented with right scrotal swelling.
  • [MeSH-major] Epididymis. Genital Neoplasms, Male / surgery. Hemangiosarcoma / surgery. Neoplasms, Second Primary / surgery

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  • (PMID = 17382180.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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67. Koch M, Nielsen GP, Yoon SS: Malignant tumors of blood vessels: angiosarcomas, hemangioendotheliomas, and hemangioperictyomas. J Surg Oncol; 2008 Mar 15;97(4):321-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant tumors of blood vessels: angiosarcomas, hemangioendotheliomas, and hemangioperictyomas.
  • Sarcomas that arise from or resemble the components of blood vessels are uncommon and include angiosarcomas, hemangioendotheliomas, and hemangiopericytomas.
  • This article reviews the management of these three types of sarcomas.
  • Diagnosis can sometimes be difficult, with the diagnosis of hemangiopericytoma versus solitary fibrous tumor currently in debate.
  • Each of these sarcomas subtypes has certain unique clinical traits.
  • For patients with advanced disease, various chemotherapeutic regimens may result in meaningful responses in a minority of patients.
  • [MeSH-major] Hemangioendothelioma / diagnosis. Hemangioendothelioma / therapy. Hemangiopericytoma / diagnosis. Hemangiopericytoma / therapy. Hemangiosarcoma / diagnosis. Hemangiosarcoma / therapy
  • [MeSH-minor] Chemotherapy, Adjuvant. Combined Modality Therapy. Humans. Neoplasms, Radiation-Induced. Prognosis. Radiotherapy / adverse effects. Skin Neoplasms / diagnosis. Skin Neoplasms / etiology. Skin Neoplasms / therapy

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 18286475.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 89
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68. Qureshi YA, Strauss DC, Thway K, Fisher C, Thomas JM: Angiosarcoma developing in a non-functioning arteriovenous fistula post-renal transplant. J Surg Oncol; 2010 May 1;101(6):520-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma developing in a non-functioning arteriovenous fistula post-renal transplant.
  • BACKGROUND: Angiosarcomas comprise less than 1% of all sarcomas, arising from endothelial cells of blood or lymph vessels.
  • Chronic immunosuppression increases the risk of many malignancies and an association between the development of angiosarcoma with an immunosuppressed state is established.
  • A few cases have been reported of angiosarcomas arising in the post-renal transplant patient.
  • Specifically, there have been six cases of an angiosarcoma arising in arteriovenous (AV) fistulae in this patient population.
  • We describe a further case and review the relevant literature with specific emphasis on a possible mechanism for the development of angiosarcoma in the post-transplant patient.
  • CASE PRESENTATION: We report the case of a 48-year-old male who developed an angiosarcoma in a ligated native AV fistula.
  • CONCLUSION: Angiosarcomas are extremely rare tumours but should be considered as a differential diagnosis for an evolving mass near the site of an AV fistula.
  • Diagnosis relies on an index of suspicion and obtaining a definitive histological diagnosis.
  • [MeSH-major] Arteriovenous Shunt, Surgical / adverse effects. Hemangiosarcoma / etiology. Kidney Transplantation. Vascular Neoplasms / etiology

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  • [Copyright] (c) 2010 Wiley-Liss, Inc.
  • (PMID = 20191610.001).
  • [ISSN] 1096-9098
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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69. Florescu M, Simionescu C, Mărgăritescu C, Georgescu CV: Gingival angiosarcoma: histopathologic and immunohistochemical study. Rom J Morphol Embryol; 2005;46(1):57-61

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gingival angiosarcoma: histopathologic and immunohistochemical study.
  • Angiosarcomas of the head and neck are rare tumors, the intra-oral localization being considered exceptionally in the specialty literature.
  • The diagnosis of this kind of tumor in gingival location is difficult, both to the rarity of this lesion at this site, and to the various histopathological aspects.
  • We present the case of 70 years old male patient clinically diagnosed with tumor of the alveolar crest of mandible, which, histopathologically, associated areas of predominant vascular proliferation, with areas of carcinoma and sarcoma.
  • [MeSH-major] Gingival Neoplasms / pathology. Hemangiosarcoma / pathology

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  • (PMID = 16286986.001).
  • [ISSN] 1220-0522
  • [Journal-full-title] Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
  • [ISO-abbreviation] Rom J Morphol Embryol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Vimentin
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70. Macák J, Skálová A: Angiosarcoma of the parotid gland. Cesk Patol; 2009 Jul;45(3):69-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma of the parotid gland.
  • Angiosarcomas of the major salivary glands are rare tumours.
  • In some parts, primitive mutually anastomosing irregularly shaped vascular spaces with atypical endothelial cells were found.
  • Due to the relatively short follow-up period the prognosis of the disease is difficult to estimate.
  • [MeSH-major] Hemangiosarcoma / pathology. Parotid Neoplasms / pathology

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  • (PMID = 19764160.001).
  • [ISSN] 1210-7875
  • [Journal-full-title] Československá patologie
  • [ISO-abbreviation] Cesk Patol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Czech Republic
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71. Brodie C, Provenzano E: Vascular proliferations of the breast. Histopathology; 2008 Jan;52(1):30-44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Clinically apparent processes are more likely to be malignant; however, a range of benign entities which must be differentiated from angiosarcoma also exists.
  • Subsequently, more diagnostically challenging, atypical haemangiomas, papillary endothelial hyperplasia, angiomatosis and angiolymphoid hyperplasia with eosinophilia (epithelioid haemangioma) are considered.
  • In addition, lesions with low-grade malignant potential such as haemangiopericytomas and epithelioid haemangioendotheliomas may rarely present in the breast.
  • However, primary angiosarcomas and radiation-associated vascular lesions are reviewed in depth, as these entities are of greatest clinical and pathological significance.
  • [MeSH-major] Breast Neoplasms / pathology. Hemangiosarcoma / pathology
  • [MeSH-minor] Diagnosis, Differential. Female. Hemangioendothelioma, Epithelioid / diagnosis. Hemangioendothelioma, Epithelioid / pathology. Hemangioma / diagnosis. Hemangioma / pathology. Hemangiopericytoma / diagnosis. Hemangiopericytoma / pathology. Humans. Hyperplasia / diagnosis. Hyperplasia / pathology. Neoplasms, Radiation-Induced / diagnosis. Neoplasms, Radiation-Induced / pathology

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  • (PMID = 18171415.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 97
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72. Moore A, Hendon A, Hester M, Samayoa L: Secondary angiosarcoma of the breast: can imaging findings aid in the diagnosis? Breast J; 2008 May-Jun;14(3):293-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Secondary angiosarcoma of the breast: can imaging findings aid in the diagnosis?
  • Secondary angiosarcomas, although rare, are aggressive tumors that can develop in breast tissue that has undergone prior radiation therapy.
  • We present three cases of secondary angiosarcoma of the breast in the setting of prior breast irradiation.
  • These imaging findings may enable the radiologist to suggest this diagnosis, even when the clinical presentation is more benign.
  • [MeSH-major] Breast Neoplasms / diagnosis. Hemangiosarcoma / diagnosis. Neoplasm Recurrence, Local / diagnosis. Neoplasms, Radiation-Induced / diagnosis

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  • (PMID = 18476885.001).
  • [ISSN] 1524-4741
  • [Journal-full-title] The breast journal
  • [ISO-abbreviation] Breast J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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73. Ordóñez NG: Podoplanin: a novel diagnostic immunohistochemical marker. Adv Anat Pathol; 2006 Mar;13(2):83-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Recent investigations have shown that podoplanin is selectively expressed in lymphatic endothelium as well as lymphangiomas, Kaposi sarcomas, and in a subset of angiosarcomas with probable lymphatic differentiation.
  • Podoplanin has also been shown to be strongly expressed in seminomas, epithelioid mesotheliomas, and hemangioblastomas, and immunostaining for this marker can assist in the diagnosis of these tumors.
  • [MeSH-major] Biomarkers, Tumor / analysis. Immunohistochemistry. Membrane Glycoproteins / analysis. Neoplasms, Germ Cell and Embryonal / diagnosis. Neoplasms, Gonadal Tissue / diagnosis. Neoplasms, Vascular Tissue / diagnosis
  • [MeSH-minor] Antibodies, Monoclonal. Antibodies, Monoclonal, Murine-Derived. Endothelium, Lymphatic / metabolism. Female. Humans. Male. Mesothelioma / diagnosis. Mesothelioma / metabolism. Ovarian Neoplasms / diagnosis

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  • (PMID = 16670463.001).
  • [ISSN] 1072-4109
  • [Journal-full-title] Advances in anatomic pathology
  • [ISO-abbreviation] Adv Anat Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Biomarkers, Tumor; 0 / Membrane Glycoproteins; 0 / PDPN protein, human; 0 / monoclonal antibody D2-40
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74. Guirguis A, Kanbour-Shakir A, Kelley J: Epithelioid angiosarcoma of the mons after chemoradiation for vulvar cancer. Int J Gynecol Pathol; 2007 Jul;26(3):265-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epithelioid angiosarcoma of the mons after chemoradiation for vulvar cancer.
  • Angiosarcomas are rare malignant tumors of endothelial origin with morphological properties similar to the vascular and lymphatic endothelium.
  • Our patient is the first case report of an angiosarcoma of the mons pubis after chemoradiation and the second reported angiosarcoma of the mons.
  • She presented 4 years later with a lesion on her mons, consistent with an angiosarcoma.
  • Angiosarcomas are rare malignant tumors of endothelial origin with morphological properties similar to the vascular and lymphatic endothelium.
  • Our patient is the first case report of an angiosarcoma of the mons pubis after chemoradiation for vulvar cancer and the second reported angiosarcoma of the mons.
  • As the treatment of vulvar cancer evolves, and more radiation therapy is given, the incidence of angiosarcomas will rise, requiring better diagnostic and treatment protocols.
  • [MeSH-major] Hemangiosarcoma / pathology. Vulvar Neoplasms / pathology

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  • (PMID = 17581409.001).
  • [ISSN] 0277-1691
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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75. Burke A: Primary malignant cardiac tumors. Semin Diagn Pathol; 2008 Feb;25(1):39-46
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary malignant cardiac tumors.
  • Approximately 10% of surgically resected heart tumors are malignant.
  • Of these, over 90% are sarcomas, and the remainder lymphomas.
  • Sarcomas of the heart may be of a variety of histologic types.
  • Angiosarcomas are usually right-sided, typically in the atrium.
  • Most other heart sarcomas arise in the left atrium and may be clinically mistaken for myxoma.
  • Left atrial sarcomas are typically pleomorphic, and may have areas of osteosarcoma or chondrosarcoma.
  • [MeSH-major] Heart Neoplasms / pathology. Lymphoma / pathology. Neoplasm Metastasis / pathology. Sarcoma / pathology

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  • (PMID = 18350921.001).
  • [ISSN] 0740-2570
  • [Journal-full-title] Seminars in diagnostic pathology
  • [ISO-abbreviation] Semin Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 45
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76. Fukunaga M: Expression of D2-40 in lymphatic endothelium of normal tissues and in vascular tumours. Histopathology; 2005 Apr;46(4):396-402
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Normal lymphatic endothelial cells in all normal tissues expressed D2-40.
  • Its positive staining delineated flattened channels or open spaces lined by a single layer of endothelial cells whose lumena were sometimes filled with lymphocytes.
  • Ten of 10 cases of lymphangioma, nine of 10 Kaposi's sarcomas (KSs), one of five spindle cell haemangiomas, one of one reactive angioenodotheliomatosis, one of one vascular transformation of lymph node sinuses, three of three Dabska tumours, one of 10 epithelioid haemangioendotheliomas (HEs) and seven of 15 angiosarcomas were positive for D2-40.
  • Positively staining angiosarcomas were characterized by epithelioid or papillary endothelial cells.
  • In comparison, CD31 was expressed in five of 10 lymphangiomas, nine of 10 KSs, 27 of 27 haemangiomas, three of three Dabska tumours, 10 of 10 epithelioid HEs, 15 of 15 angiosarcomas and one of one each of retiform HE, Kaposiform HE, reactive angioendotheliomatosis, and vascular transformation of node sinuses.
  • The findings support the concept that these tumours show at least partial lymphatic endothelial differentiation.
  • Subsets of angiosarcomas and HEs show both vascular and lymphatic endothelial differentiation.

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  • (PMID = 15810951.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antigens, CD31; 0 / Antigens, Neoplasm; 0 / monoclonal antibody D2-40; 0 / oncofetal antigens
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77. Gamlem H, Nordstoga K, Arnesen K: Canine vascular neoplasia--a population-based clinicopathologic study of 439 tumours and tumour-like lesions in 420 dogs. APMIS Suppl; 2008;(125):41-54

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A distinction is made between benign neoplasms, tumours of intermediate malignancy, and obvious malignant processes (angiosarcomas).
  • Splenic involvement was followed by the liver, with 13 out of 17 processes being angiosarcomas.
  • Eleven of 12 heart tumours were angiosarcomas.
  • Most tumour-like proliferations were papillary endothelial hyperplasias.
  • Recurrence occurred in 17 dogs, some of which had received a primary benign diagnosis.
  • Dissemination involved a further 23 cases (22 had angiosarcoma).
  • The male/female rate of benign tumours was 0.78, for tumour-like processes 1.83, intermediate malignant tumours 1.65, and angiosarcomas 1.60.
  • [MeSH-minor] Animals. Dogs. Female. Hemangioma / pathology. Hemangioma / veterinary. Hemangiosarcoma / pathology. Hemangiosarcoma / veterinary. Lymphangioma / pathology. Lymphangioma / veterinary. Male

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  • (PMID = 19385280.001).
  • [ISSN] 0903-465X
  • [Journal-full-title] APMIS. Supplementum
  • [ISO-abbreviation] APMIS Suppl.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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78. Chen YB, Guo LC, Yang L, Feng W, Zhang XQ, Ling CH, Ji C, Huang JA: Angiosarcoma of the lung: 2 cases report and literature reviewed. Lung Cancer; 2010 Dec;70(3):352-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma of the lung: 2 cases report and literature reviewed.
  • Angiosarcoma is a kind of malignant tumors derived from vascular endothelial cell.
  • Pulmonary angiosarcomas are usually secondary tumors, and primary cases are less than 20 so far.
  • Here we presented two cases of angiosarcoma involved the lung, and we only confirmed case 2 as a primary pulmonary angiosarcoma.
  • The clinical characteristics, diagnosis, treatment options and prognosis of pulmonary angiosarcoma were reviewed in this article too.
  • [MeSH-major] Brain Neoplasms / diagnosis. Hemangiosarcoma / diagnosis. Liver Neoplasms / diagnosis. Lung Neoplasms / diagnosis

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  • [Copyright] Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 20952087.001).
  • [ISSN] 1872-8332
  • [Journal-full-title] Lung cancer (Amsterdam, Netherlands)
  • [ISO-abbreviation] Lung Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Antigens, CD34
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79. Skubitz KM, Haddad PA: Paclitaxel and pegylated-liposomal doxorubicin are both active in angiosarcoma. Cancer; 2005 Jul 15;104(2):361-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Paclitaxel and pegylated-liposomal doxorubicin are both active in angiosarcoma.
  • BACKGROUND: Paclitaxel has unique activity in angiosarcomas of the face and scalp, but its activity in angiosarcomas originating at other sites is less well defined.
  • Paclitaxel and pegylated-liposomal doxorubicin (PLD) are highly effective in Kaposi sarcoma (KS).
  • Because of the efficacy of PLD in soft tissue sarcoma in general, and in KS in particular, coupled with potential similarities in KS and angiosarcoma, and the apparent activity of paclitaxel in angiosarcomas, the authors treated patients with angiosarcoma with either paclitaxel or PLD as initial chemotherapy.
  • METHODS: To better define the efficacy of these agents in angiosarcoma, the authors reviewed their experience with paclitaxel and PLD in patients with angiosarcoma treated between 1994 and 2004.
  • RESULTS: They identified seven patients with angiosarcoma treated with paclitaxel, and six treated with PLD.
  • Only one patient in the series had an angiosarcoma of the scalp.
  • Of the eight patients treated with paclitaxel, five had major responses (three had partial responses [PR] and two had complete disease remission [CR]) and three had progressive disease (PD).
  • Of the 6 patients who received PLD, 3 had a PR for 6, 19, and >20 months, respectively, 2 had stable disease for 7 and 11 months, respectively, and 1 had PD.
  • CONCLUSIONS: The current study demonstrated the activity of PLD (five of six patients experienced clinical benefit) and extended the data on paclitaxel in angiosarcoma, both of the face and scalp, as well as angiosarcoma originating at other sites.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Doxorubicin / therapeutic use. Hemangiosarcoma / drug therapy. Paclitaxel / therapeutic use

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  • (PMID = 15948172.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 30IQX730WE / Polyethylene Glycols; 80168379AG / Doxorubicin; P88XT4IS4D / Paclitaxel
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80. Wang XY, Jakowski J, Tawfik OW, Thomas PA, Fan F: Angiosarcoma of the breast: a clinicopathologic analysis of cases from the last 10 years. Ann Diagn Pathol; 2009 Jun;13(3):147-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma of the breast: a clinicopathologic analysis of cases from the last 10 years.
  • Breast angiosarcoma may occur de novo, or as a complication of radiation therapy, or chronic lymphedema secondary to axillary lymph node dissection for mammary carcinoma.
  • In our effort to characterize the clinicopathologic features of breast angiosarcoma, we reviewed all breast angiosarcoma cases in the University of Kansas Medical Center and Ohio State University Medical Center archives from 1997 to 2007.
  • Only 11 angiosarcomas were identified among more than 5000 malignant breast neoplasms (0.1%-0.2% incidence) for the last 10 years.
  • Eight cases (6 high grade, 1 intermediate grade, 1 low grade) were identified as postradiation angiosarcoma (postradiation time interval, 4-12 years), and 3 cases were identified as primary angiosarcomas (1 high grade, 2 low grade).
  • Follow-up (median, 36 months) revealed that 3 cases of postradiation angiosarcoma recurred as skin and/or chest wall lesions and 1 case of primary angiosarcoma developed liver metastases (all high-grade).
  • In conclusion, breast angiosarcoma remains a rare disease.
  • Rosen's method for grading breast angiosarcoma is easy to implement and correlates well with clinical outcome.
  • There are no distinct clinical or histologic differences between primary and postradiation breast angiosarcomas.
  • [MeSH-major] Breast Neoplasms / pathology. Hemangiosarcoma / pathology

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  • (PMID = 19433291.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 12
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81. Vertse G, Svastics E, Iványi A: [Postirradiation angiosarcoma of the breast]. Magy Seb; 2010 Aug;63(4):164-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Postirradiation angiosarcoma of the breast].
  • [Transliterated title] Besugárzás utáni angiosarcoma emloben.
  • Although secondary angiosarcomas (AS) are relatively rare neoplasms, they are increasingly recognized as the result of more breast conserving therapy (BCT) followed by radiotherapy.
  • The diagnosis of this very aggressive and rapidly spreading tumour is based on the immunohystochemical characteristics of the biopsy specimen.
  • [MeSH-major] Breast Neoplasms / radiotherapy. Hemangiosarcoma / diagnosis. Hemangiosarcoma / etiology. Mastectomy, Segmental. Neoplasms, Second Primary / diagnosis. Neoplasms, Second Primary / etiology

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  • (PMID = 20724241.001).
  • [ISSN] 0025-0295
  • [Journal-full-title] Magyar sebészet
  • [ISO-abbreviation] Magy Seb
  • [Language] hun
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Hungary
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers, Tumor
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82. Souza FF, Katkar A, den Abbeele AD, Dipiro PJ: Breast angiosarcoma metastatic to the ovary. Case Rep Med; 2009;2009:381015
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Breast angiosarcoma metastatic to the ovary.
  • Primary angiosarcoma can arise anywhere in the body and when it arises in the breast, it usually affects women in their 3rd and 4th decades and accounts for one in 1700-2300 cases of primary breast cancer.
  • Although unusual, breast angiosarcomas tend to metastasize hematogenously rather than lymphogenously, have high rates of local recurrence, that often develop metastases soon after treatment, and have a dismal prognosis.
  • We present a case of a solitary ovarian metastasis from angiosarcoma of the breast.

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  • [Cites] Breast Cancer. 2006;13(4):369-73 [17146165.001]
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  • (PMID = 19718246.001).
  • [ISSN] 1687-9627
  • [Journal-full-title] Case reports in medicine
  • [ISO-abbreviation] Case Rep Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2729273
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83. Plotnik AN, Schweder P, Tsui A, Kavar B: Splenic angiosarcoma metastasis to the brain. J Clin Neurosci; 2008 Aug;15(8):927-9
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  • [Title] Splenic angiosarcoma metastasis to the brain.
  • Angiosarcoma is a rare primary non-haematolymphoid malignant neoplasm of the spleen.
  • This neoplastic process has a poor prognosis, with disease usually widespread by the time of presentation.
  • In the literature there has been only six case reports of cerebral metastasis from splenic angiosarcomas.
  • We report a 61-year-old woman who presented with a right occipital metastasis of a splenic angiosarcoma, 5 years after initial diagnosis, treated by stereotactic occipital craniotomy and resection of metastasis.
  • [MeSH-major] Brain Neoplasms / secondary. Hemangiosarcoma / pathology. Splenic Neoplasms / pathology

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  • (PMID = 18411053.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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84. Ozcelik C, Onat S, Yaldiz M, Ozcelik Z: Primary epithelioid angiosarcoma of the lung presenting as pulmonary hemorrhage. Asian Cardiovasc Thorac Ann; 2006 Feb;14(1):69-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary epithelioid angiosarcoma of the lung presenting as pulmonary hemorrhage.
  • Pulmonary angiosarcomas are usually secondary tumors, and only a few primary cases have been reported.
  • We report a unique case of epithelioid angiosarcoma presenting as a solitary mass in the right upper lobe with pulmonary hemorrhage.
  • Because of its epithelioid histology, this tumor may resemble a carcinoma or a variety of vascular lesions with epithelioid endothelial cells.
  • Therefore, the diagnosis of epithelioid angiosarcoma should be based on immunohistochemical staining.
  • [MeSH-major] Epithelioid Cells / pathology. Hemangiosarcoma / diagnosis. Hemorrhage / etiology. Lung Diseases / etiology. Lung Neoplasms / diagnosis
  • [MeSH-minor] Chest Pain / etiology. Cough / etiology. Diagnosis, Differential. Fatal Outcome. Hemoptysis / etiology. Humans. Immunohistochemistry. Lung / diagnostic imaging. Lung / pathology. Lung / surgery. Male. Middle Aged. Rare Diseases. Tomography, X-Ray Computed

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  • (PMID = 16432125.001).
  • [ISSN] 1816-5370
  • [Journal-full-title] Asian cardiovascular & thoracic annals
  • [ISO-abbreviation] Asian Cardiovasc Thorac Ann
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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85. Mullah-Ali A, Ramsay JA, Bourgeois JM, Hodson I, Macdonald P, Midia M, Portwine C: Paraspinal synovial sarcoma as an unusual postradiation complication in pediatric abdominal neuroblastoma. J Pediatr Hematol Oncol; 2008 Jul;30(7):553-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Paraspinal synovial sarcoma as an unusual postradiation complication in pediatric abdominal neuroblastoma.
  • SUMMARY: The development of a soft-tissue sarcoma is an infrequent but well-known long-term complication of radiotherapy.
  • Malignant fibrous histiocytomas, extraskeletal osteosarcomas, fibrosarcomas, malignant peripheral nerve sheath tumors, and angiosarcomas are most frequently encountered.
  • Radiation-associated synovial sarcomas are uncommon and exceedingly rare in pediatric patients.
  • We report an unusual case of paraspinal synovial sarcoma presenting in an adolescent female 13 years after radiation therapy for her neuroblastoma.
  • [MeSH-major] Muscle Neoplasms / etiology. Neoplasms, Radiation-Induced / etiology. Neoplasms, Second Primary / etiology. Neuroblastoma / radiotherapy. Retroperitoneal Neoplasms / radiotherapy. Sarcoma, Synovial / etiology


86. Gajda M, Hommann M, Böttcher J, Henning K, Kaiser WA, Settmacher U, Katenkamp D: [Primary liposarcoma of the liver--a rare mesenchymal tumor]. Z Gastroenterol; 2007 Dec;45(12):1241-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Most often angiosarcomas have been reported.
  • [MeSH-major] Liposarcoma / diagnosis. Liver Neoplasms / diagnosis
  • [MeSH-minor] Cell Nucleus / pathology. Diagnosis, Differential. Female. Hepatectomy. Humans. Liver / pathology. Magnetic Resonance Imaging. Middle Aged

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  • (PMID = 18080225.001).
  • [ISSN] 0044-2771
  • [Journal-full-title] Zeitschrift für Gastroenterologie
  • [ISO-abbreviation] Z Gastroenterol
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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87. Tahir M, Hendry P, Baird L, Qureshi NA, Ritchie D, Whitford P: Radiation induced angiosarcoma a sequela of radiotherapy for breast cancer following conservative surgery. Int Semin Surg Oncol; 2006;3:26

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Radiation induced angiosarcoma a sequela of radiotherapy for breast cancer following conservative surgery.
  • Radiation induced angiosarcomas (RIA) can affect breast cancer patients who had radiotherapy following conservative breast surgery.
  • They are very rare tumors and often their diagnosis is delayed due to their benign appearance and difficulty in differentiation from radiation induced skin changes.

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  • [Cites] Int J Radiat Oncol Biol Phys. 1999 Apr 1;44(1):113-9 [10219803.001]
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  • (PMID = 16965616.001).
  • [ISSN] 1477-7800
  • [Journal-full-title] International seminars in surgical oncology : ISSO
  • [ISO-abbreviation] Int Semin Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1570350
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88. Requena L, Santonja C, Stutz N, Kaddu S, Weenig RH, Kutzner H, Menzel T, Cerroni L: Pseudolymphomatous cutaneous angiosarcoma: a rare variant of cutaneous angiosarcoma readily mistaken for cutaneous lymphoma. Am J Dermatopathol; 2007 Aug;29(4):342-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pseudolymphomatous cutaneous angiosarcoma: a rare variant of cutaneous angiosarcoma readily mistaken for cutaneous lymphoma.
  • Cutaneous angiosarcoma is probably the most malignant neoplasm involving the skin.
  • Three clinical variants of cutaneous angiosarcoma are recognized, including angiosarcoma of the scalp and face of elderly patients, angiosarcoma associated with chronic lymphedema, and postirradiation angiosarcoma.
  • Histopathologically, these three variants of angiosarcoma show similar features, which consist of poorly circumscribed, irregularly dilated, and anastomosing vascular channels lined by prominent endothelial cells that dissect through the dermis.
  • Focally, neoplastic endothelial cells show large, hyperchromatic, and pleomorphic nuclei, protruding within vascular lumina and creating small papillations.
  • In rare instances, cutaneous angiosarcomas may exhibit prominent inflammatory infiltrate, and the neoplasm may be mistaken for an inflammatory process, both from clinical and histopathologic points of view.
  • We describe four examples of cutaneous angiosarcomas with dense lymphocytic infiltrates involving the neoplasm.
  • The neoplastic endothelial cells expressed immunoreactivity for the CD31, CD34, podoplanin, Prox-1, Lyve-1, and D2-40.
  • We discuss the possible relationship between neoplastic endothelial lymphatic cells and reactive lymphocytes.
  • Cutaneous angiosarcoma with prominent lymphocytic infiltrate may be readily mistaken for cutaneous follicle center cell lymphoma or cutaneous pseudolymphoma.
  • [MeSH-major] Hemangiosarcoma / diagnosis. Lymphoma / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged. Breast Neoplasms / diagnosis. Diagnosis, Differential. Endothelial Cells / pathology. Endothelium, Vascular / pathology. Facial Neoplasms / diagnosis. Female. Humans. Lymphocytes / pathology. Lymphoma, Follicular / diagnosis. Male. Middle Aged. Neovascularization, Pathologic / pathology. Pseudolymphoma / diagnosis. Scalp / pathology. Skin Diseases / diagnosis

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  • (PMID = 17667166.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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89. Jha S, Chan KK, Poole CJ, Rollason TP: Pregnancy following recurrent angiosarcoma of the ovary--a case report and review of literature. Gynecol Oncol; 2005 Jun;97(3):935-7
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  • [Title] Pregnancy following recurrent angiosarcoma of the ovary--a case report and review of literature.
  • BACKGROUND: Ovarian angiosarcomas are rare tumors which may to be distinguished from other unusual primary ovarian tumors such as clear cell carcinoma, yolk sac tumor and leiomyosarcoma on the basis of histological appearance and immunohistochemistry.
  • Angiosarcomas of the ovary occur in all age groups but are more frequent in women of child bearing age (less than 40 years).
  • CASE: The case we present is the only reported long-term survivor of recurrent ovarian angiosarcoma.
  • CONCLUSION: Adjuvant chemotherapy of ovarian angiosarcoma with a combination of doxorubicin and ifosfamide appears effective and should be considered in women at risk of relapse who wish to conserve fertility.
  • [MeSH-major] Hemangiosarcoma / therapy. Neoplasm Recurrence, Local. Ovarian Neoplasms / therapy. Pregnancy Complications, Neoplastic

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  • (PMID = 15943995.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 80168379AG / Doxorubicin; UM20QQM95Y / Ifosfamide
  • [Number-of-references] 15
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90. Zanetta L, Corada M, Grazia Lampugnani M, Zanetti A, Breviario F, Moons L, Carmeliet P, Pepper MS, Dejana E: Downregulation of vascular endothelial-cadherin expression is associated with an increase in vascular tumor growth and hemorrhagic complications. Thromb Haemost; 2005 Jun;93(6):1041-6
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  • [Title] Downregulation of vascular endothelial-cadherin expression is associated with an increase in vascular tumor growth and hemorrhagic complications.
  • The pathogenesis of vascular tumors such as angiosarcomas is poorly understood.
  • Cadherin expression inversely correlates with tumor malignancy and the endothelial specific VE-cadherin is low or absent in angiosarcomas, suggesting an inhibitory role for this protein in tumor progression.
  • In this paper we report that PmyT VE-cadherin null (VEC null) endothelial cells form larger vascular tumors in nude mice when injected subcutaneously as compared to isogenic VE-cadherin positive (VEC pos) cells.
  • Overall, these data strongly suggest that downregulation of VE-cadherin in endothelial tumors may have important consequences for tumor growth and bleeding complications.
  • [MeSH-major] Cadherins / genetics. Hemangiosarcoma / etiology. Hemorrhage / etiology

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  • (PMID = 15968386.001).
  • [ISSN] 0340-6245
  • [Journal-full-title] Thrombosis and haemostasis
  • [ISO-abbreviation] Thromb. Haemost.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Cadherins; 0 / Plasminogen Activator Inhibitor 1; 0 / RNA, Messenger; 0 / cadherin 5
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91. Vogt T: [Angiosarcoma]. Hautarzt; 2008 Mar;59(3):237-48; quiz 249-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Angiosarcoma].
  • [Transliterated title] Angiosarkom.
  • Angiosarcomas are rare tumors accounting for 1-2% of all soft tissue sarcomas.
  • Angiosarcoma favors superficial soft tissues and skin (60%) with a clear predilection for the head and neck region.
  • The average age of the patients presenting with cutaneous angiosarcomas is around 70 years with a peak incidence in the 8th decade.
  • Secondary angiosarcoma after tissue-conserving radiation therapy for carcinoma of the breast represents an increasing problem, both the differentiation between atypical vascular lesions and true aggressive angiosarcoma and the therapy are challenging.
  • The prognosis for angiosarcoma patients is gloomy despite all therapeutic efforts.
  • [MeSH-major] Hemangiosarcoma / diagnosis. Hemangiosarcoma / therapy. Skin Neoplasms / diagnosis. Skin Neoplasms / therapy

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  • (PMID = 18273583.001).
  • [ISSN] 1432-1173
  • [Journal-full-title] Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
  • [ISO-abbreviation] Hautarzt
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 27
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92. Ordóñez NG: D2-40 and podoplanin are highly specific and sensitive immunohistochemical markers of epithelioid malignant mesothelioma. Hum Pathol; 2005 Apr;36(4):372-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] D2-40 and podoplanin are highly specific and sensitive immunohistochemical markers of epithelioid malignant mesothelioma.
  • Recent investigations have shown that podoplanin and the D2-40 monoclonal antibody, which reacts with an oncofetal antigen present in fetal germ cells, are highly reliable lymphatic endothelial markers.
  • The observation that both of these markers are also expressed in normal and reactive mesothelial cells prompted an investigation into their potential value in the diagnosis of mesotheliomas.
  • To determine whether podoplanin and D2-40 had any use in the diagnosis of these tumors, 40 mesotheliomas (29 epithelioid, 5 biphasic, and 6 sarcomatoid), 34 carcinomas of the lung (24 adenocarcinomas, 10 squamous carcinomas), 80 nonpulmonary adenocarcinomas (17 ovary, 10 breast, 10 colon, 10 kidney, 5 endometrium, 5 stomach, 5 pancreas, 5 prostate, 3 thyroid), 12 synovial sarcomas (6 biphasic and 6 monophasic), 5 angiosarcomas, and 2 adenomatoid tumors were immunostained with a monoclonal antibody to podoplanin and with the D2-40 antibody.
  • Positivity for D2-40 and podoplanin was also seen in the epithelioid components of 4 of 5 biphasic mesotheliomas and 4 of 6 synovial sarcomas, whereas the spindle cell components of these tumors were negative as were the monophasic synovial sarcomas.
  • Two (40%) of the 5 angiosarcomas expressed these markers, thus confirming previous reports suggesting that some angiosarcomas may have lymphatic endothelial differentiation.
  • Both of the adenomatoid tumors were also positive for D2-40 and podoplanin, a finding which provides further support for the mesothelial derivation of these tumors.
  • It is concluded that, because of their high specificity and sensitivity for epithelioid mesotheliomas, D2-40 and podoplanin are very useful markers for the diagnosis of these tumors.
  • [MeSH-major] Antibodies, Monoclonal / analysis. Membrane Glycoproteins / analysis. Mesothelioma / diagnosis

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  • (PMID = 15891998.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Membrane Glycoproteins; 0 / PDPN protein, human; 0 / monoclonal antibody D2-40; 0 / oncofetal antigens
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93. Fayette J, Martin E, Piperno-Neumann S, Le Cesne A, Robert C, Bonvalot S, Ranchère D, Pouillart P, Coindre JM, Blay JY: Angiosarcomas, a heterogeneous group of sarcomas with specific behavior depending on primary site: a retrospective study of 161 cases. Ann Oncol; 2007 Dec;18(12):2030-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcomas, a heterogeneous group of sarcomas with specific behavior depending on primary site: a retrospective study of 161 cases.
  • BACKGROUND: Angiosarcomas are rare, heterogeneous and a retrospective study was conducted to describe their natural history.
  • PATIENTS AND METHODS: We reviewed 161 files of angiosarcoma treated in three institutions of the French Sarcoma Group from 1980 to 2004.
  • At initial diagnosis, 31 (19%) had metastases.
  • With an average time since initial diagnosis of 8.1 years, 123 (76%) patients progressed and 76 (47%) died.
  • In multivariate analysis, liver primary site [relative risk (RR) = 12.62], performance status (PS) of two or more (RR = 3.83), presence of metastases at diagnosis (RR = 2.50), soft tissue tumor (RR = 0.31) were correlated to OS.
  • CONCLUSIONS: Angiosarcomas have an overall poor outcome, but with a clearly distinct prognosis depending on the primary site.

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  • (PMID = 17974557.001).
  • [ISSN] 1569-8041
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] England
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94. Quesenberry CD, Li C, Chen AH, Zweizig SL, Ball HG 3rd: Primary angiosarcoma of the ovary: a case report of Stage I disease. Gynecol Oncol; 2005 Oct;99(1):218-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary angiosarcoma of the ovary: a case report of Stage I disease.
  • BACKGROUND: There are 20 documented cases of primary ovarian angiosarcoma.
  • Most patients present with metastatic disease and respond poorly to chemotherapy.
  • CASE: We present a case of Stage Ic primary ovarian angiosarcoma treated with 3 cycles of adjuvant MAID chemotherapy.
  • The patient is without evidence of disease 10 months post-operatively.
  • CONCLUSION: A review of the literature indicates a potential role for MAID chemotherapy in the treatment of ovarian angiosarcomas.
  • Detection of Stage I disease appears to confer a better prognosis regardless of the utilization of adjuvant chemotherapy.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Hemangiosarcoma / drug therapy. Ovarian Neoplasms / drug therapy

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  • (PMID = 16081151.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 7GR28W0FJI / Dacarbazine; 80168379AG / Doxorubicin; NR7O1405Q9 / Mesna; UM20QQM95Y / Ifosfamide; MAID protocol
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95. Tavora F, Montgomery E, Epstein JI: A series of vascular tumors and tumorlike lesions of the bladder. Am J Surg Pathol; 2008 Aug;32(8):1213-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We identified 13 lesions that included 3 hemangiomas, 3 intravascular papillary endothelial hyperplasias (Masson vegetant hemangioendotheliomas), 2 arteriovenous malformations (AVMs), 1 epithelioid hemangioendothelioma (EHE), and 4 angiosarcomas.
  • One of the angiosarcomas was associated with conventional high-grade urothelial carcinoma (sarcomatoid carcinoma).
  • There was no statistical difference among the various lesions in terms of age, although angiosarcomas tended to arise in older patients (mean 71 y vs. 60 y of the remainder).
  • Hematuria was the most common presentation of both benign and malignant lesions.
  • Histologically, benign and malignant lesions were similar to their counterparts in other organ systems.
  • Patients with hemangiomas, papillary endothelial hyperplasias, and AVM had an invariably benign prognosis and needed no further therapy.
  • All cases of angiosarcoma and EHE involved the muscularis propria.
  • Two of four patients with angiosarcoma had a history of prior radiation therapy and all 4 were dead of disease at 6 months.
  • Angiosarcomas measured 3, 4.5, 5, and 5.8 cm in greatest diameter at cystoscopy.
  • The patient with EHE had a single nodule treated by transurethral resection of the bladder and no evidence of disease at 4 years of follow-up.
  • A wide spectrum of benign, intermediate malignant, and malignant vascular lesions primarily involved the bladder.
  • Papillary endothelial hyperplasia occurs in the bladder and must be differentiated from angiosarcoma, which has a rapidly fatal outcome.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Arteriovenous Malformations / pathology. Endothelium, Vascular / pathology. Female. Hemangioendothelioma / pathology. Hemangioendothelioma, Epithelioid / pathology. Hemangioma / pathology. Hemangiosarcoma / pathology. Hematuria / etiology. Humans. Hyperplasia. Male. Middle Aged. Neoplasm Invasiveness. Prognosis. Retrospective Studies

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  • (PMID = 18580491.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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96. Indelicato DJ, Keole SR, Shahlaee AH, Morris CG, Gibbs CP, Scarborough MT, Islam S, Marcus RB: Ewing tumors of the chest wall: Local control and long-term outcomes. J Clin Oncol; 2009 May 20;27(15_suppl):e21501

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • : e21501 Background: Primary sarcomas of the lungs and mediastinum are rare and few data are reported on treatment and results of therapy.
  • Pts characteristics: median age 41 (19-80 y), male/female 19/12; symptoms at diagnosis: dyspnoea (42%), chest and shoulder pain (39%), cough (35%), hemophtoae (13%), discomfort (10%).
  • 5 mediastinal tumours were located as follows: 2 in anterior part, 1 in posterior and 2 in the middle (sarcomas of the heart).
  • 26 lung sarcomas presented as a singular mass in 23 cases and as a metastatic disease in 3.
  • RESULTS: In 20/31 cases the tumour was immediately resected (3 mediastinal masses and 17 lung sarcomas).
  • The histology were: peripheral nerve tumour 7, leiomyosarcoma 4, MFH 2, fibrosarcoma 2, liposarcoma 1, angiosarcoma 2, undifferentiated sarcoma 1, solitary fibrous tumour 2, rhabdomyosarcoma 2, synovialsarcoma 2, pulmonary artery sarcoma 1, pleuropolmonary blastoma 1, malignant hemangiopericytoma 1, mixoid chondrosarcoma 1, ectopic osteosarcoma 1, aggressive fibromatosis 1.
  • Only 4 pts received neoadjuvant chemotherapy, 11 adjuvant CT, 5 exclusive CT + RT for inoperable disease.
  • Of these only 8 are alive (2 with disease).
  • Volume of disease, complete resection and grading are the dominant prognostic factors.
  • CONCLUSIONS: Primary sarcomas of the lungs and mediastinum have a very severe prognosis.

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  • (PMID = 27963390.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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97. Deyrup AT, Miettinen M, North PE, Khoury JD, Tighiouart M, Spunt SL, Parham D, Weiss SW, Shehata BM: Angiosarcomas arising in the viscera and soft tissue of children and young adults: a clinicopathologic study of 15 cases. Am J Surg Pathol; 2009 Feb;33(2):264-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcomas arising in the viscera and soft tissue of children and young adults: a clinicopathologic study of 15 cases.
  • Angiosarcomas are rare tumors that predominantly affect adult and elderly patients and pursue an aggressive clinical course with high mortality.
  • Although angiosarcomas are well described in a variety of clinical settings, they have been incompletely characterized.
  • We identified 15 high-grade angiosarcomas arising from the viscera and soft tissue of patients 21 years old and younger from institutional and consultation files.
  • Tumors arose in both sexes (8 males; 7 females); age at diagnosis ranged from 3 months to 19 years (mean, 10 y, 5 mo; median, 11 y).
  • Clinical follow-up was obtained for all patients: 10 (67%) died of disease (range, 27 mo to 11 y; mean, 6 y 8 mo) and 4 patients were alive without disease (range, 27 to 132 mo; mean, 79 mo).
  • Although extremely rare, angiosarcomas do affect children and young adults and this diagnosis should be considered in atypical vascular tumors occurring in the mediastinum and those with brisk mitotic activity and/or necrosis.
  • [MeSH-major] Hemangiosarcoma / pathology. Soft Tissue Neoplasms / pathology. Viscera / pathology

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  • (PMID = 18987547.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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98. Abbott R, Palmieri C: Angiosarcoma of the breast following surgery and radiotherapy for breast cancer. Nat Clin Pract Oncol; 2008 Dec;5(12):727-36
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma of the breast following surgery and radiotherapy for breast cancer.
  • Breast angiosarcoma following surgery and radiotherapy for breast cancer is a rare but important clinical entity.
  • This article reviews all published cases and includes data on incidence, etiology, presentation, diagnosis, management and prognosis.
  • Breast angiosarcoma remains challenging clinically, radiologically and histologically, and thus a high index of suspicion is required in susceptible patients.
  • There have been recent reports of patients with metastatic disease responding to taxane chemotherapy, and there might be a future role for targeted agents given the expression of c-KIT in a subset of angiosarcomas.
  • [MeSH-major] Breast Neoplasms / epidemiology. Hemangiosarcoma / epidemiology. Neoplasm Recurrence, Local / epidemiology. Neoplasms, Radiation-Induced

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  • (PMID = 18936792.001).
  • [ISSN] 1743-4262
  • [Journal-full-title] Nature clinical practice. Oncology
  • [ISO-abbreviation] Nat Clin Pract Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 90
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99. Erpolat OP, Icli F, Dogan OV, Gokaslan G, Akmansu M, Erekul S, Yucel E: Primary cardiac angiosarcoma: a case report. Tumori; 2008 Nov-Dec;94(6):892-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary cardiac angiosarcoma: a case report.
  • Cardiac angiosarcomas are malignant tumors that almost always have a poor prognosis.
  • We describe a 29-year-old man with primary cardiac angiosarcoma with multiple site metastases.
  • We discuss the diagnosis and treatment of cardiac angiosarcoma in the light of a case report.
  • [MeSH-major] Heart Neoplasms / pathology. Hemangiosarcoma / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male. Prognosis. Tomography, X-Ray Computed

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  • (PMID = 19267115.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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100. Arribas-Garcia I, Domínguez MF, Alcalá-Galiano A, García AF, Valls JC, De Rasche EN: Oral primary angiosarcoma of the lower lip mucosa: report of a case in a 15-year-old boy. Head Neck; 2008 Oct;30(10):1384-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Oral primary angiosarcoma of the lower lip mucosa: report of a case in a 15-year-old boy.
  • BACKGROUND: Angiosarcomas are rare soft tissue malignant tumors with dismal prognosis.
  • METHODS AND RESULTS: We present the case of an inferior lip mucosal low-grade angiosarcoma in a 15-year-old boy treated exclusively with surgery.
  • Prompt and accurate diagnosis with adequate imaging modalities and multidisciplinary treatment are crucial for optimal management of these neoplasms.
  • [MeSH-major] Hemangiosarcoma. Lip Neoplasms

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  • [Copyright] Copyright (c) 2008 Wiley Periodicals, Inc. Head Neck 2008.
  • (PMID = 18286486.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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