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1. Weaver J, Billings SD: Postradiation cutaneous vascular tumors of the breast: a review. Semin Diagn Pathol; 2009 Aug;26(3):141-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Postradiation cutaneous vascular tumors of the breast: a review.
  • (1) postradiation cutaneous angiosarcoma, malignant vascular neoplasms with significant morbidity and mortality; and (2) atypical vascular lesions (AVL), vascular tumors that reportedly behave in a benign manner.
  • Although first described separately 15 years ago, the relationship between postradiation cutaneous angiosarcoma and AVL remains controversial.
  • It appears that, in at least some cases, angiosarcoma can arise in the context of AVL, suggesting that these lesions are part of a spectrum of the same disease process.
  • Herein, we will discuss the evolution of this topic while reviewing the various clinical, histopathologic, and prognostic characteristics of postradiation cutaneous angiosarcoma and AVL.
  • [MeSH-major] Breast Neoplasms / radiotherapy. Hemangiosarcoma / pathology. Neoplasms, Radiation-Induced / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Female. Humans. Middle Aged. Neoplasm Recurrence, Local. Prognosis

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  • (PMID = 20043513.001).
  • [ISSN] 0740-2570
  • [Journal-full-title] Seminars in diagnostic pathology
  • [ISO-abbreviation] Semin Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 21
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2. Spillane EL, Xia Y, Turiansky GW: Atypical cutaneous presentation of Waldenström macroglobulinemia: an extensive erythematous patch mimicking an angiosarcoma. Cutis; 2008 Jan;81(1):67-8
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  • [Title] Atypical cutaneous presentation of Waldenström macroglobulinemia: an extensive erythematous patch mimicking an angiosarcoma.
  • Waldenström macroglobulinemia (WM) is an immunoglobulin M-producing lymphoproliferative disorder in elderly individuals.
  • Cutaneous manifestations of WM are rare and typically consist of plaques or nodules.
  • We describe a case of a man with WM who presented with an extensive erythematous patch on the scalp that clinically mimicked an angiosarcoma.
  • [MeSH-major] Hemangiosarcoma / diagnosis. Skin / pathology. Skin Neoplasms / diagnosis. Waldenstrom Macroglobulinemia / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged. Scalp / pathology

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  • (PMID = 18306851.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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3. Sakurai H, Hada M, Miyashita Y, Tsukamoto K, Oyama T, Ashizawa I: Simultaneous bilateral spontaneous pneumothorax secondary to metastatic angiosarcoma of the scalp: report of a case. Surg Today; 2006;36(10):919-22
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  • [Title] Simultaneous bilateral spontaneous pneumothorax secondary to metastatic angiosarcoma of the scalp: report of a case.
  • Angiosarcoma is a highly malignant neoplasm, which most often develops on the scalp or face of elderly people.
  • Common distant metastatic sites include the lung, liver, lymph nodes, and skin.
  • We report a case of angiosarcoma manifesting as simultaneous bilateral spontaneous pneumothorax secondary to pulmonary metastases in an 86-year-old man.
  • The pneumothorax preceded the diagnosis of angiosarcoma.
  • This case suggests that a finding of simultaneous bilateral spontaneous pneumothorax may indicate a serious parenchymal lung disorder.
  • [MeSH-major] Head and Neck Neoplasms / complications. Hemangiosarcoma / complications. Lung Neoplasms / complications. Pneumothorax / etiology. Scalp. Skin Neoplasms / complications


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4. Grewal JS, Daniel AR, Carson EJ, Catanzaro AT, Shehab TM, Tworek JA: Rapidly progressive metastatic multicentric epithelioid angiosarcoma of the small bowel: a case report and a review of literature. Int J Colorectal Dis; 2008 Aug;23(8):745-56
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  • [Title] Rapidly progressive metastatic multicentric epithelioid angiosarcoma of the small bowel: a case report and a review of literature.
  • BACKGROUND: Angiosarcoma is a rare high-grade neoplasm that frequently involves the skin and subcutaneous tissue.
  • Rarely, angiosarcoma can occur in the gastrointestinal tract where it frequently exhibits multicentric epithelioid morphology.
  • DESIGN: We report a case of multicentric epithelioid angiosarcoma (EAS) of the small intestine in a 73-year-old male patient who presented with weakness and melena, and was found to have bleeding lesions in the small intestine on upper gastrointestinal endoscopy.
  • In addition to this case, we extensively reviewed the clinical and pathological features of previously reported cases of angiosarcoma of the small intestine in the English literature since 1970.
  • He died within 4 months of the diagnosis.
  • CONCLUSIONS: Angiosarcoma, especially of the deep tissues and the gastrointestinal tract, is very aggressive and rapidly metastatic.
  • The survival rate in these patients is extremely poor, and most patients die within 6 months to 1 year of the diagnosis.
  • [MeSH-major] Hemangiosarcoma / pathology. Hemangiosarcoma / secondary. Intestinal Neoplasms / pathology. Intestine, Small / pathology

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  • (PMID = 18080128.001).
  • [ISSN] 0179-1958
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 59
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5. Chiu LS, Wong KH, Lam WY, Luk NM, Lo KK: Angiosarcoma of the scrotum after treatment of cancer of the rectum. Clin Exp Dermatol; 2006 Sep;31(5):706-7
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  • [Title] Angiosarcoma of the scrotum after treatment of cancer of the rectum.
  • [MeSH-major] Hemangiosarcoma / etiology. Rectal Neoplasms / therapy. Scrotum. Skin Neoplasms / etiology. Testicular Neoplasms / etiology

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  • (PMID = 16901314.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
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6. Emberger M, Laimer M, Steiner H, Zelger B: Retiform hemangioendothelioma: presentation of a case expressing D2-40. J Cutan Pathol; 2009 Sep;36(9):987-90
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  • Retiform hemangioendothelioma (RH) is a low-grade angiosarcoma with low metastatic risk, usually occurring as a single lesion on the trunk or extremity in middle-aged adults.
  • [MeSH-major] Antibodies, Monoclonal / metabolism. Hemangioendothelioma / pathology. Skin Neoplasms / pathology

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  • (PMID = 19674202.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Biomarkers, Tumor; 0 / monoclonal antibody D2-40
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7. Scheinfeld N: Review of scalp alopecia due to a clinically unapparent or minimally apparent neoplasm (SACUMAN). Acta Derm Venereol; 2006;86(5):387-92
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  • [Title] Review of scalp alopecia due to a clinically unapparent or minimally apparent neoplasm (SACUMAN).
  • Neoplastic cells, both malignant and benign, local occurring and metastatic, can cause alopecia of the scalp.
  • However, the infiltration of neoplastic cells is sometimes not florid; a condition known as "scalp alopecia due to a clinically unapparent or minimally apparent neoplasm" (SACUMAN).
  • The most common neoplasm in which an uncomplicated, minimally or unapparent scalp alopecia occurs and no infiltrate of cancer is suspected is metastatic breast carcinoma.
  • Other causes include squamous and basal cell carcinomas, angiosarcoma, gastric carcinoma, placental site tromphoblastic tumor, and mycosis fungoides.
  • Dermatologists must be aware that in rare cases a bland scalp alopecia can represent a new or recurring, local or metastatic neoplasm.
  • [MeSH-major] Alopecia / etiology. Skin Neoplasms / pathology
  • [MeSH-minor] Breast Neoplasms / pathology. Carcinoma, Basal Cell / pathology. Cicatrix / pathology. Hemangiosarcoma / pathology. Humans. Keloid / complications. Keloid / pathology. Lymphoma / pathology. Scalp / pathology

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  • (PMID = 16983449.001).
  • [ISSN] 0001-5555
  • [Journal-full-title] Acta dermato-venereologica
  • [ISO-abbreviation] Acta Derm. Venereol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Norway
  • [Number-of-references] 56
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8. Costache M, Ene AM, Simionescu O, Sajin M: Histopathological diagnosis of cutaneous vascular sarcomas. Rom J Morphol Embryol; 2010;51(1):105-9
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  • [Title] Histopathological diagnosis of cutaneous vascular sarcomas.
  • Cutaneous sarcomas represent a heterogeneous group of mesenchymal lesions.
  • This study investigates the histopathological and immunohistochemical features in different cases of angiosarcoma and Kaposi's sarcoma (cutaneous vascular sarcomas), which are representative for medical practice.
  • The clinical-histopathological-immunohistochemical correlations render possible the differential diagnosis and a proper treatment can be applied to obtain a favorable prognosis.
  • [MeSH-major] Hemangiosarcoma / diagnosis. Hemangiosarcoma / pathology. Skin Neoplasms / diagnosis. Skin Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Prognosis. Sarcoma, Kaposi / diagnosis. Sarcoma, Kaposi / pathology

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  • (PMID = 20191128.001).
  • [ISSN] 1220-0522
  • [Journal-full-title] Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
  • [ISO-abbreviation] Rom J Morphol Embryol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Romania
  • [Number-of-references] 18
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9. Weed BR, Folpe AL: Cutaneous CD30-positive epithelioid angiosarcoma following breast-conserving therapy and irradiation: a potential diagnostic pitfall. Am J Dermatopathol; 2008 Aug;30(4):370-2
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  • [Title] Cutaneous CD30-positive epithelioid angiosarcoma following breast-conserving therapy and irradiation: a potential diagnostic pitfall.
  • A case of cutaneous epithelioid angiosarcoma with anomalous CD30 expression, occurring after breast-conserving surgery and adjuvant irradiation, is reported.
  • The differential diagnosis of CD30 epithelioid angiosarcoma is discussed.
  • [MeSH-major] Antigens, CD30 / biosynthesis. Hemangiosarcoma / metabolism. Neoplasms, Radiation-Induced / metabolism. Neoplasms, Second Primary / metabolism. Skin Neoplasms / metabolism
  • [MeSH-minor] Aged, 80 and over. Breast Neoplasms / radiotherapy. Breast Neoplasms / surgery. Carcinoma, Ductal, Breast / radiotherapy. Carcinoma, Ductal, Breast / surgery. Combined Modality Therapy. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Lymphoma, Large-Cell, Anaplastic / pathology. Radiotherapy, Adjuvant / adverse effects

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  • (PMID = 18645308.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD30
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10. Shrestha DB, Ravichandran D, Pittam M: Discolouration of breast skin following breast conservation therapy for breast cancer: a cautionary tale of two patients. Int J Clin Pract; 2010 Jan;64(1):112-3
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  • [Title] Discolouration of breast skin following breast conservation therapy for breast cancer: a cautionary tale of two patients.
  • [MeSH-minor] Aged. Fatal Outcome. Female. Hemangiosarcoma / etiology. Hemangiosarcoma / surgery. Humans. Lymphatic Metastasis. Middle Aged. Neoplasm Recurrence, Local / surgery. Radiotherapy / adverse effects

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  • (PMID = 20089025.001).
  • [ISSN] 1742-1241
  • [Journal-full-title] International journal of clinical practice
  • [ISO-abbreviation] Int. J. Clin. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] Angiosarcoma of the breast
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11. Venkataraman G, Hammadeh R: Report of an angiosarcoma mimic: cutaneous aneurysmal fibrous histiocytoma. APMIS; 2006 Oct;114(10):744-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Report of an angiosarcoma mimic: cutaneous aneurysmal fibrous histiocytoma.
  • It looks strikingly different from the usual cutaneous lesions encountered in clinical dermatology practice.
  • A single report of a cutaneous aneurysmal fibrous histiocytoma in the skin of the back of a 60-year-old male is described with emphasis on the immunostaining pattern and review of the literature.
  • There is a significant potential for confusion of this lesion with other cutaneous lesions, clinically as well as pathologically.
  • In our case, the patient presented with a lesion that clinically resembled a hemangioma, was pathologically interpreted initially to be an angiosarcoma, and finally, the revised pathology was interpreted as an aneurysmal variant of a fibrous histiocytoma.
  • Caution is warranted to avoid misinterpretation of cutaneous fibrohistiocytic tumors.
  • [MeSH-major] Histiocytoma, Benign Fibrous / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aneurysm / pathology. Diagnosis, Differential. Humans. Male. Middle Aged

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  • (PMID = 17004978.001).
  • [ISSN] 0903-4641
  • [Journal-full-title] APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
  • [ISO-abbreviation] APMIS
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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12. Ettl T, Kleinheinz J, Mehrotra R, Schwarz S, Reichert TE, Driemel O: Infraorbital cutaneous angiosarcoma: a diagnostic and therapeutic dilemma. Head Face Med; 2008;4:18
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  • [Title] Infraorbital cutaneous angiosarcoma: a diagnostic and therapeutic dilemma.
  • BACKGROUND: A cutaneous angiosarcoma is a rare malignant tumour of vascular endothelial cells with aggressive clinical behaviour and poor prognosis.
  • Diagnosis is often delayed due to its variable and often benign clinical appearance.
  • Histopathologic examination of the specimen diagnosed a cutaneous angiosarcoma.
  • Neither, finally achieved negative margins on permanent sections, nor a following chemotherapy could prevent the recurrence of the disease after five months and the patient's dead 21 months after the first diagnosis.
  • [MeSH-major] Facial Neoplasms / pathology. Hemangiosarcoma / pathology. Neoplasm Recurrence, Local / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Biopsy, Needle. Chemotherapy, Adjuvant. Combined Modality Therapy. Disease Progression. Fatal Outcome. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Staging. Radiotherapy, Adjuvant. Reoperation

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  • (PMID = 18694495.001).
  • [ISSN] 1746-160X
  • [Journal-full-title] Head & face medicine
  • [ISO-abbreviation] Head Face Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2533304
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13. Kantrow SM, Boyd AS: Primary cutaneous metaplastic carcinoma: report of a case involving angiosarcoma. Am J Dermatopathol; 2007 Jun;29(3):270-3
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  • [Title] Primary cutaneous metaplastic carcinoma: report of a case involving angiosarcoma.
  • Primary cutaneous metaplastic carcinoma is an uncommon cutaneous malignancy comprising a mixture of epithelial and mesenchymal components.
  • The former is most frequently a squamous cell or basal cell carcinoma, and the latter is most typically a pleomorphic sarcoma or atypical fibroxanthoma.
  • We describe the first primary cutaneous metaplastic carcinoma with angiosarcoma as the mesenchymal component arising on the scalp of a 90-year-old woman.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Carcinosarcoma / pathology. Hemangiosarcoma / pathology. Neoplasms, Multiple Primary / pathology. Skin Neoplasms / pathology

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  • (PMID = 17519625.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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14. Brenn T, Fletcher CD: Radiation-associated cutaneous atypical vascular lesions and angiosarcoma: clinicopathologic analysis of 42 cases. Am J Surg Pathol; 2005 Aug;29(8):983-96
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  • [Title] Radiation-associated cutaneous atypical vascular lesions and angiosarcoma: clinicopathologic analysis of 42 cases.
  • Cutaneous angiosarcoma is a rare but well-recognized complication after radiation therapy.
  • A total of 42 cases diagnosed as either radiation-associated cutaneous vascular lesions or angiosarcoma were retrieved from departmental and consultation files from 1995 to 2003.
  • Reasons for radiation included breast carcinoma (35 cases) and a variety of other lesions (mainly malignant disease).
  • The time interval from radiation was significantly shorter for the development of AVL (median, 3.5 years) compared with cutaneous angiosarcoma (median, 6 years).
  • Histologic evaluation revealed 26 lesions meeting criteria for angiosarcoma, ranging from morphologically low-grade to high-grade; 16 cases were classified as AVLs.
  • All patients with systemic relapse had an initial diagnosis of angiosarcoma.
  • One patient with an AVL had a recurrence at the same site, 3 patients developed additional new lesions, and 1 patient developed multiple small papules on the chest wall, which progressed from an AVL to angiosarcoma.
  • This study outlines the morphologic spectrum of radiation-associated cutaneous AVLs.
  • [MeSH-major] Hemangiosarcoma / etiology. Hemangiosarcoma / pathology. Neoplasms, Radiation-Induced / pathology. Skin / blood supply. Skin / pathology. Skin Neoplasms / etiology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Breast Neoplasms / radiotherapy. Female. Follow-Up Studies. Humans. Middle Aged. Neoplasm Recurrence, Local. Neoplasms / radiotherapy. Time Factors

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  • (PMID = 16006792.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. Penel N, Bui BN, Bay JO, Cupissol D, Ray-Coquard I, Piperno-Neumann S, Kerbrat P, Fournier C, Taieb S, Jimenez M, Isambert N, Peyrade F, Chevreau C, Bompas E, Brain EG, Blay JY: Phase II trial of weekly paclitaxel for unresectable angiosarcoma: the ANGIOTAX Study. J Clin Oncol; 2008 Nov 10;26(32):5269-74
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  • [Title] Phase II trial of weekly paclitaxel for unresectable angiosarcoma: the ANGIOTAX Study.
  • PURPOSE: The objective of this phase II trial was to assess the efficacy and toxicity of weekly paclitaxel for patients with metastatic or unresectable angiosarcoma.
  • Three patients with locally advanced breast angiosarcoma presented partial response, which enabled a secondary curative-intent surgery with complete histologic response in two cases.
  • [MeSH-major] Antineoplastic Agents, Phytogenic / administration & dosage. Breast Neoplasms / drug therapy. Head and Neck Neoplasms / drug therapy. Hemangiosarcoma / drug therapy. Paclitaxel / administration & dosage. Scalp. Skin Neoplasms / drug therapy. Soft Tissue Neoplasms / drug therapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Disease-Free Survival. Drug Administration Schedule. Female. France / epidemiology. Humans. Infusions, Intravenous. Kaplan-Meier Estimate. Male. Middle Aged. Neoplasm Metastasis. Time Factors. Treatment Outcome

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  • (PMID = 18809609.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; P88XT4IS4D / Paclitaxel
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16. Cronin H, Mowad C, Ferringer T: Large nodular plaque on leg in the setting of chronic lymphedema--quiz case. Angiosarcoma in the setting of familial lymphedema. Arch Dermatol; 2010 Mar;146(3):337-42
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  • [Title] Large nodular plaque on leg in the setting of chronic lymphedema--quiz case. Angiosarcoma in the setting of familial lymphedema.
  • [MeSH-major] Hemangiosarcoma / diagnosis. Lymphedema / complications. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adult. Biopsy. Chronic Disease. Diagnosis, Differential. Humans. Leg. Male

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  • (PMID = 20231513.001).
  • [ISSN] 1538-3652
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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17. De Smet S, Vandermeeren L, Christiaens MR, Samson I, Stas M, Van Limbergen E, De Wever I: Radiation-induced sarcoma: analysis of 46 cases. Acta Chir Belg; 2008 Sep-Oct;108(5):574-9
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  • [Title] Radiation-induced sarcoma: analysis of 46 cases.
  • A retrospective analysis was performed of 46 cases of sarcoma treated in our institution between 1989 and 2007 that occurred in a previously irradiated area.
  • The interval between irradiation and the diagnosis of sarcoma ranged from 1 to 54 years (median 15 y).
  • The most common clinical findings were a mass, pain and skin dislocation.
  • Angiosarcoma and sarcoma non-otherwise-specified were the most common histological types.
  • Stage and location of the sarcoma were other prognostic factors.
  • [MeSH-major] Neoplasms, Radiation-Induced / mortality. Neoplasms, Radiation-Induced / surgery. Sarcoma / mortality. Sarcoma / surgery
  • [MeSH-minor] Abdominal Neoplasms / mortality. Abdominal Neoplasms / pathology. Abdominal Neoplasms / surgery. Adult. Aged. Aged, 80 and over. Extremities. Female. Head and Neck Neoplasms / mortality. Head and Neck Neoplasms / pathology. Head and Neck Neoplasms / surgery. Humans. Lung Neoplasms / mortality. Lung Neoplasms / pathology. Lung Neoplasms / surgery. Male. Middle Aged. Neoplasm Metastasis. Pelvic Neoplasms / mortality. Pelvic Neoplasms / pathology. Pelvic Neoplasms / surgery. Retrospective Studies. Thoracic Neoplasms / mortality. Thoracic Neoplasms / pathology. Thoracic Neoplasms / surgery. Young Adult

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  • (PMID = 19051469.001).
  • [ISSN] 0001-5458
  • [Journal-full-title] Acta chirurgica Belgica
  • [ISO-abbreviation] Acta Chir. Belg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Belgium
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18. Sutton VR, Hopkins BJ, Eble TN, Gambhir N, Lewis RA, Van den Veyver IB: Facial and physical features of Aicardi syndrome: infants to teenagers. Am J Med Genet A; 2005 Oct 15;138A(3):254-8
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  • Aicardi syndrome is a sporadic disorder that affects primarily females and is hypothesized to be caused by heterozygous mutations in an X-linked gene.
  • Various skin lesions (including multiple nevi, skin tags, hemangiomas, one giant melanotic nevus, and a history of a previously removed angiosarcoma) were present in 8/40 (20%).


19. Al Dhaybi R, Agoumi M, Powell J, Dubois J, Kokta V: Lymphangiosarcoma complicating extensive congenital mixed vascular malformations. Lymphat Res Biol; 2010 Sep;8(3):175-9
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  • Pediatric hepatic angiosarcoma is a very rare malignant vascular tumor.
  • A few cases have shown pediatric hepatic angiosarcoma occurring on a background of preexisting vascular lesions.
  • We report the case of a newborn girl who presented extensive limbs and upper trunk cutaneous mixed vascular malformations at birth.
  • Cutaneous biopsies revealed complex vascular malformations with a significant lymphatic component.
  • Compressive body suit therapy led to regression of the limbs' cutaneous vascular malformations.
  • The autopsy's pathological examination revealed a hepatic-based angiosarcoma with plurimetastatic dissemination to the spleen, lungs, peritoneum, pleura, mesenteric linings as well as the serosa of the stomach and small intestine.
  • Multiple cutaneous and visceral complex capillaro-lymphatico-venous malformations were also identified.
  • We hypothesize that these multiple extensive mixed vascular malformations were associated with chronic lymphedema which probably predisposed to the development of the angiosarcoma in our patient.
  • [MeSH-minor] Autopsy. Fatal Outcome. Female. Humans. Infant. Infant, Newborn. Skin Diseases, Vascular / complications. Skin Diseases, Vascular / congenital. Skin Diseases, Vascular / drug therapy

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  • (PMID = 20863270.001).
  • [ISSN] 1557-8585
  • [Journal-full-title] Lymphatic research and biology
  • [ISO-abbreviation] Lymphat Res Biol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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20. Inaba T, Yamanaka K, Asahi K, Omoto Y, Isoda K, Hurwitz D, Kupper TS, Mizutani H: Complete remission in a patient with angiosarcoma by the combination of OK-432, rhIL-2, and radiotherapy. Eur J Dermatol; 2005 Sep-Oct;15(5):411-3
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  • [Title] Complete remission in a patient with angiosarcoma by the combination of OK-432, rhIL-2, and radiotherapy.
  • [MeSH-major] Antineoplastic Agents / administration & dosage. Head and Neck Neoplasms / drug therapy. Hemangiosarcoma / therapy. Interleukin-2 / administration & dosage. Picibanil / administration & dosage. Skin Neoplasms / therapy

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  • [CommentOn] Eur J Dermatol. 1999 Mar;9(2):118-21 [10066960.001]
  • (PMID = 16208887.001).
  • [ISSN] 1167-1122
  • [Journal-full-title] European journal of dermatology : EJD
  • [ISO-abbreviation] Eur J Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Comment; Letter
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Interleukin-2; 0 / Recombinant Proteins; 39325-01-4 / Picibanil
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21. Gherardi G, Rossi S, Perrone S, Scanni A: Angiosarcoma after breast-conserving therapy: fine-needle aspiration biopsy, immunocytochemistry, and clinicopathologic correlates. Cancer; 2005 Jun 25;105(3):145-51
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  • [Title] Angiosarcoma after breast-conserving therapy: fine-needle aspiration biopsy, immunocytochemistry, and clinicopathologic correlates.
  • BACKGROUND: Angiosarcoma that arises after breast-conserving therapy can present clinically as a cutaneous and/or subcutaneous breast lump, which is misinterpreted easily as a recurrence of carcinoma.
  • To the authors' knowledge, the role of fine-needle aspiration (FNA) cytology in the early diagnosis of this life-threatening complication of breast carcinoma therapy has not been established fully.
  • METHODS: The authors studied three new patients with this type of secondary angiosarcoma diagnosed by FNA biopsy and immunocytochemistry, reviewed the literature on the topic, and examined relevant differential diagnostic issues.
  • RESULTS: Patients presented with a discrete skin lump that had arisen several years after breast-conservative therapy for early-stage breast carcinoma near the scar from the previous surgery.
  • Immunostaining of smears, however, provided conclusive evidence of the endothelial differentiation of tumor cells, and an FNA diagnosis of angiosarcoma was rendered in all patients.
  • The histopathology of all surgically excised tumors confirmed the diagnosis of high-grade angiosarcoma.
  • CONCLUSIONS: Based on the authors' experience, the FNA cytologic appearance of angiosarcoma that presented as a breast skin nodule in a breast carcinoma survivor easily could have been misinterpreted as carcinoma.
  • A correct diagnosis of this tumor relies on the proper evaluation of clinical findings and, as also shown by a review of the literature, requires immunocytochemical evidence of endothelial differentiation.
  • [MeSH-major] Biopsy, Fine-Needle. Breast Neoplasms / pathology. Breast Neoplasms / surgery. Hemangiosarcoma / secondary. Mastectomy, Segmental / adverse effects. Skin Neoplasms / secondary
  • [MeSH-minor] Aged. Aged, 80 and over. Carcinoma in Situ / pathology. Carcinoma in Situ / surgery. Carcinoma, Ductal, Breast / secondary. Carcinoma, Ductal, Breast / surgery. Carcinoma, Lobular / secondary. Carcinoma, Lobular / surgery. Female. Humans. Immunohistochemistry. Neoplasm Staging. Prognosis. Risk Assessment. Sampling Studies. Sensitivity and Specificity. Survival Rate

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  • (PMID = 15844179.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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22. Lee BA, Wanat KA, Eisen AZ: Cutaneous angiosarcoma of the knee: a case report and review of the literature. Cutis; 2009 Feb;83(2):91-4
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  • [Title] Cutaneous angiosarcoma of the knee: a case report and review of the literature.
  • Cutaneous angiosarcoma is a rare, malignant, vascular tumor that usually occurs in the scalp and face region of elderly white men.
  • We report an unusual case of angiosarcoma occurring on the knee of a 70-year-old white woman with a strong family history of malignant melanoma in the absence of any known predisposing features.
  • [MeSH-major] Hemangiosarcoma / diagnosis. Knee Joint / pathology. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans

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  • (PMID = 19326694.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 19
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23. Tanabe K, Masuzawa M, Aki R, Masuzawa M, Arai S, Hayakawa K, Katsuoka K, Kobayashi T: Angiosarcoma of the scalp with metastasis to the gingiva. Acta Derm Venereol; 2008;88(5):512-3
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  • [Title] Angiosarcoma of the scalp with metastasis to the gingiva.
  • [MeSH-major] Gingival Neoplasms / secondary. Hemangiosarcoma / pathology. Hemangiosarcoma / secondary. Scalp / pathology. Skin Neoplasms / pathology

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  • (PMID = 18779896.001).
  • [ISSN] 0001-5555
  • [Journal-full-title] Acta dermato-venereologica
  • [ISO-abbreviation] Acta Derm. Venereol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Sweden
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24. Tucci E, Della Rocca C, Santilli F: Localized bacillary angiomatosis in the oral cavity: observations about a neoplasm with atypical behavior. Description of a case and review of the literature. Minerva Stomatol; 2006 Jan-Feb;55(1-2):67-75
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  • [Title] Localized bacillary angiomatosis in the oral cavity: observations about a neoplasm with atypical behavior. Description of a case and review of the literature.
  • Bacillary angiomatosis is a rather frequent infectious pathology appearing mainly in the skin but can also affect the liver, spleen, heart, bones, lungs, muscles, central nervous system and other organs.
  • Bacillary angiomatosis can be clinically similar to the Kaposi's sarcoma and histologically confused with angiosarcoma, epitheloid hemangioma and pyogenic granuloma.
  • The high tendency to relapse, the capability in migration and to involve several localizations at the same time have induced the authors to deepen the research to exclude the possibility that it could be a Kaposi's sarcoma or a pyogenic granuloma and to get to an accurate diagnosis in order to resolve the disease.
  • [MeSH-major] Angiomatosis, Bacillary / diagnosis. Gingivitis / diagnosis
  • [MeSH-minor] Adolescent. Adult. Ampicillin / analogs & derivatives. Ampicillin / therapeutic use. Bartonella henselae / pathogenicity. Bartonella quintana / pathogenicity. Child. Chlorhexidine / therapeutic use. Combined Modality Therapy. Diagnosis, Differential. Female. Gingival Neoplasms / diagnosis. Granuloma, Pyogenic / diagnosis. Hemangioendothelioma, Epithelioid / diagnosis. Hemangiosarcoma / diagnosis. Humans. Male. Pregnancy. Pregnancy Complications, Neoplastic / diagnosis. Recurrence. Sarcoma, Kaposi / diagnosis. Tooth Extraction

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  • (PMID = 16495874.001).
  • [ISSN] 0026-4970
  • [Journal-full-title] Minerva stomatologica
  • [ISO-abbreviation] Minerva Stomatol
  • [Language] eng; ita
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 7C782967RD / Ampicillin; 8GM2J22278 / bacampicillin; R4KO0DY52L / Chlorhexidine
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25. Santos P, Pinto GM, Pereira A, Cruz T, Afonso A, Cardoso J: Sequential treatment of angiosarcoma of the back with liposomal doxorubicin and radiotherapy. J Eur Acad Dermatol Venereol; 2005 Nov;19(6):779-80
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  • [Title] Sequential treatment of angiosarcoma of the back with liposomal doxorubicin and radiotherapy.
  • [MeSH-major] Antibiotics, Antineoplastic / therapeutic use. Back. Doxorubicin / therapeutic use. Hemangiosarcoma / drug therapy. Hemangiosarcoma / radiotherapy. Skin Neoplasms / drug therapy. Skin Neoplasms / radiotherapy

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  • (PMID = 16268901.001).
  • [ISSN] 0926-9959
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Liposomes; 80168379AG / Doxorubicin
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26. Dubner S, Bovi J, White J, Susnik B: Postirradiation morphea in a breast cancer patient. Breast J; 2006 Mar-Apr;12(2):173-6
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  • We present the case of a 52-year-old woman who underwent lumpectomy and radiation therapy for breast carcinoma and 2 years later presented with changes limited to the breast radiation field including hyperpigmentation, retraction, and skin thickening.
  • It is important to be aware of this rare complication of radiation therapy because it clinically presents with symptoms mimicking malignancy and may be misinterpreted as recurrent carcinoma or even angiosarcoma.
  • [MeSH-minor] Female. Humans. Mastectomy, Segmental. Middle Aged. Radiotherapy, Adjuvant. Skin Pigmentation. Time Factors


27. Wray JD, Bestbier M, Miller J, Smith KC: Aortic and iliac thrombosis associated with angiosarcoma of skeletal muscle in a dog. J Small Anim Pract; 2006 May;47(5):272-7
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  • [Title] Aortic and iliac thrombosis associated with angiosarcoma of skeletal muscle in a dog.
  • Ischaemic necrosis of areas of the hindlimb digits and skin and a firm swelling within the medial right thigh musculature were found on physical examination.
  • Necropsy findings were of a poorly differentiated invasive sarcoma of the skeletal muscle of the proximal right hindlimb, thrombosis of the aorta and right external iliac artery and secondary renal glomerulopathy.
  • Immunohistochemistry of the neoplastic tissue indicated angiosarcoma based on expression of CD31 and factor VIII-related antigen.
  • Aortoiliac thrombosis, paraparesis and hindlimb ischaemia are unusual sequelae of angiosarcoma in the dog.
  • [MeSH-major] Dog Diseases / diagnosis. Hemangiosarcoma / veterinary. Muscle Neoplasms / veterinary

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  • (PMID = 16674722.001).
  • [ISSN] 0022-4510
  • [Journal-full-title] The Journal of small animal practice
  • [ISO-abbreviation] J Small Anim Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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28. Aguiar Bujanda D, Camacho Galán R, Bastida Iñarrea J, Aguiar Morales J, Conde Martel A, Rivero Suárez P, de Armas Diaz F, Bohn Sarmiento U, Cabrera Suárez MA: Angiosarcoma of the abdominal wall after dermolipectomy in a morbidly obese man. A rare form of presentation of Stewart-Treves syndrome. Eur J Dermatol; 2006 May-Jun;16(3):290-2
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  • [Title] Angiosarcoma of the abdominal wall after dermolipectomy in a morbidly obese man. A rare form of presentation of Stewart-Treves syndrome.
  • Angiosarcoma is a rare malignant tumor, with a predilection for skin in the head and neck region, although it has been described in many other locations.
  • However, angiosarcoma can appear in lower limbs with chronic lymphedema and rarely in other locations such as the abdominal wall.
  • Herein, we present a unique case of angiosarcoma developing in the abdominal wall of a morbidly obese patient after extensive dermolipectomy.
  • [MeSH-major] Abdominal Wall / pathology. Dermatologic Surgical Procedures. Hemangiosarcoma / diagnosis. Lipectomy / methods. Obesity, Morbid / complications

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  • (PMID = 16709497.001).
  • [ISSN] 1167-1122
  • [Journal-full-title] European journal of dermatology : EJD
  • [ISO-abbreviation] Eur J Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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29. Selim A, Khachemoune A, Lockshin NA: Angiosarcoma: a case report and review of the literature. Cutis; 2005 Nov;76(5):313-7
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  • [Title] Angiosarcoma: a case report and review of the literature.
  • Angiosarcoma is an aggressive neoplasm that predominantly affects elderly patients.
  • [MeSH-major] Hemangiosarcoma / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. Humans. Male. Nose / pathology. Nose / surgery. Radiotherapy, Adjuvant

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  • (PMID = 16422466.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 28
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30. Peramiquel L, Barnadas MA, Sancho J, Curell R, Alonso MC, Fuentes MJ, Pernas S, Gómez A, Alomar A: [Angiosarcoma in an irradiated breast: a case description]. Actas Dermosifiliogr; 2005 Nov;96(9):602-6
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  • [Title] [Angiosarcoma in an irradiated breast: a case description].
  • [Transliterated title] Angiosarcoma en mama irradiada: descripción de un caso.
  • Post-radiotherapy cutaneous angiosarcomas have been described in different locations, including the breast.
  • We present a case of cutaneous angiosarcoma of the breast, diagnosed 6 years after a carcinoma of the breast had been treated with radiation.
  • The histology of the skin biopsies showed angiomatous proliferation throughout the entire dermis, with no cellular atypia.
  • Considering the patient's symptoms, history and the changes observed via mammography, it was decided to completely excise the lesion followed by a simple mastectomy, with the diagnosis of angiosarcoma being confirmed.
  • Despite this fact, two years and one month later, the angiosarcoma recurred on the internal area of the mastectomy scar.
  • This complication usually appears 5-10 years after treatment with radiotherapy, so angiosarcoma should be ruled out if any angiomatous lesions later appear on skin that had been irradiated.
  • [MeSH-major] Breast Neoplasms / etiology. Breast Neoplasms / radiotherapy. Carcinoma, Ductal, Breast / radiotherapy. Hemangiosarcoma / etiology. Neoplasms, Radiation-Induced / etiology. Skin Neoplasms / etiology

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  • (PMID = 16476306.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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31. Silvariño R, Mérola V, Fígoli L, Romero C, Lapiedra J, Alonso J: [Stewart-Treves syndrome: report of one case]. Rev Med Chil; 2010 Jan;138(1):73-6
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  • Angiosarcomas are malignant tumors derived from the endothelium of blood vessel (hemangiosarcomas) or lymph vessels (lymphangiosarcomas).
  • It appears as nodular skin lesions that grow, multiply quickly and frequently metastasize.
  • We report a 40-year-old mole with an angiosarcoma associated with primary chronic lower limb lymph edema.
  • A biopsy of one of the skin lesions disclosed an angiosarcoma, diagnosis that was confirmed with immuno-histochemistry Chemotherapy was started but the patient died five months after the diagnosis.

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  • (PMID = 20361154.001).
  • [ISSN] 0034-9887
  • [Journal-full-title] Revista médica de Chile
  • [ISO-abbreviation] Rev Med Chil
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Chile
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32. Arbiser JL, Bonner MY, Berrios RL: Hemangiomas, angiosarcomas, and vascular malformations represent the signaling abnormalities of pathogenic angiogenesis. Curr Mol Med; 2009 Nov;9(8):929-34
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  • Angiogenesis is a major factor in the development of benign, inflammatory, and malignant processes of the skin.
  • Endothelial cells are the effector cells of angiogenesis, and understanding their response to growth factors and inhibitors is critical to understanding the pathogenesis and treatment of skin disease.
  • Furthermore, we have studied malignant vascular tumors, including hemangioendothelioma and angiosarcoma and have shown distinct signaling abnormalities in these tumors.
  • The incidence of these tumors is expected to rise due to environmental insults, such as radiation and lumpectomy for breast cancer, dietary and industrial carcinogens (hepatic angiosarcoma), and chronic ultraviolet exposure and potential Agent Orange exposure.
  • [MeSH-major] Hemangioma / blood supply. Hemangiosarcoma / blood supply. Neovascularization, Pathologic / pathology. Signal Transduction. Vascular Malformations / physiopathology


33. Long CT, Luong R: What's your diagnosis. Tail mass in a mouse. Cutaneous hemangiosarcoma. Lab Anim (NY); 2009 Feb;38(2):49-51
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  • [Title] What's your diagnosis. Tail mass in a mouse. Cutaneous hemangiosarcoma.
  • [MeSH-major] Hemangiosarcoma / veterinary. Skin Neoplasms / veterinary
  • [MeSH-minor] Angiomatosis / diagnosis. Animals. Animals, Outbred Strains. Diagnosis, Differential. Fatal Outcome. Female. Hemangioma / diagnosis. Hematoma / diagnosis. Mice. Tail

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  • (PMID = 19165190.001).
  • [ISSN] 0093-7355
  • [Journal-full-title] Lab animal
  • [ISO-abbreviation] Lab Anim (NY)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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34. DeMartelaere SL, Roberts D, Burgess MA, Morrison WH, Pisters PW, Sturgis EM, Ho V, Esmaeli B: Neoadjuvant chemotherapy-specific and overall treatment outcomes in patients with cutaneous angiosarcoma of the face with periorbital involvement. Head Neck; 2008 May;30(5):639-46
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  • [Title] Neoadjuvant chemotherapy-specific and overall treatment outcomes in patients with cutaneous angiosarcoma of the face with periorbital involvement.
  • BACKGROUND: Recent isolated case reports have suggested a potential role for neoadjuvant chemotherapy in patients with angiosarcoma.
  • The goal of this report was to investigate the overall treatment outcomes and the neoadjuvant chemotherapy-specific outcomes in patients with cutaneous angiosarcoma of the face with periorbital involvement.
  • METHODS: Our tumor database was searched for patients with angiosarcoma and periorbital involvement seen at our institution between 1981 and 2005.
  • CONCLUSION: On the basis of this series, the authors conclude that neoadjuvant chemotherapy for periorbital angiosarcoma is a potentially attractive option and in some patients may obviate the need for major surgery, thereby preserving the eye and/or ocular adnexal structures.
  • [MeSH-major] Eyelid Neoplasms / therapy. Facial Neoplasms / therapy. Hemangiosarcoma / therapy. Neoadjuvant Therapy. Skin Neoplasms / therapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Chemotherapy, Adjuvant. Disease-Free Survival. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Radiotherapy, Adjuvant. Retrospective Studies. Survival Analysis

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  • (PMID = 18213722.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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35. Uno H, Sasaki M, Osamura K, Ohtoshi S, Nakada T, Iijima M: Angiosarcoma (Stewart-Treves syndrome): palliative role of Mohs' ointment. J Dermatol; 2010 Sep;37(9):852-3
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  • [Title] Angiosarcoma (Stewart-Treves syndrome): palliative role of Mohs' ointment.
  • [MeSH-major] Chlorides / therapeutic use. Ointments / therapeutic use. Skin Neoplasms / drug therapy. Zinc Compounds / therapeutic use
  • [MeSH-minor] Aged. Antigens, CD31 / analysis. Antigens, CD34 / analysis. Fatal Outcome. Female. Hemangiosarcoma / drug therapy. Hemangiosarcoma / pathology. Humans. Lymphangiosarcoma / drug therapy. Lymphangiosarcoma / pathology

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  • (PMID = 20883379.001).
  • [ISSN] 1346-8138
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Antigens, CD34; 0 / Chlorides; 0 / Ointments; 0 / Zinc Compounds; 86Q357L16B / zinc chloride; Stewart Treves syndrome
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36. Vogt T, Brockmeyer N, Kutzner H, Schöfer H: Short German guidelines: angiosarcoma and Kaposi sarcoma. J Dtsch Dermatol Ges; 2008 May;6 Suppl 1:S19-24
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  • [Title] Short German guidelines: angiosarcoma and Kaposi sarcoma.
  • [MeSH-major] Dermatology / standards. Hemangiosarcoma / diagnosis. Hemangiosarcoma / therapy. Medical Oncology / standards. Practice Guidelines as Topic. Sarcoma, Kaposi / diagnosis. Sarcoma, Kaposi / therapy. Skin Neoplasms / diagnosis. Skin Neoplasms / therapy

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  • (PMID = 18801138.001).
  • [ISSN] 1610-0387
  • [Journal-full-title] Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
  • [ISO-abbreviation] J Dtsch Dermatol Ges
  • [Language] eng; ger
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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37. Constantinou C, Sheldon D: Papillary endothelial hyperplasia of the adrenal gland: report of a case and review of the literature. Am Surg; 2008 Sep;74(9):813-6
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  • Papillary endothelial hyperplasia (PEH) is a benign vascular proliferative process most frequently seen in the skin and integument, but may involve any of the visceral organs.
  • Pathologic differentiation from angiosarcoma can be a difficult task requiring evaluation by an experienced pathologist.

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  • (PMID = 18807668.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 27
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38. Fessa CK, Sharma R, Fernández-Peñas P: Cutaneous epithelioid angiosarcoma occurring at a peristomal site. J Am Acad Dermatol; 2010 Aug;63(2):e55-6
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  • [Title] Cutaneous epithelioid angiosarcoma occurring at a peristomal site.
  • [MeSH-major] Colostomy. Hemangiosarcoma / pathology. Skin Neoplasms / pathology

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  • (PMID = 20633792.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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39. Yoon TY, Kim HJ, Kim JW, Kim MK, Lee JY: Bowen's disease concealed by purpura. J Dermatol; 2007 Jan;34(1):65-7
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  • However, angiosarcoma has not usually been mentioned in the differential diagnosis of BD before.
  • Herein, we describe two cases of BD presenting as purpura on the scalp of the elderly with an initial clinical suspicion of angiosarcoma.
  • [MeSH-major] Bowen's Disease / complications. Purpura / complications. Scalp. Skin Neoplasms / complications
  • [MeSH-minor] Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans

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  • (PMID = 17204105.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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40. Perry B, Banyard J, McLaughlin ER, Watnick R, Sohn A, Brindley DN, Obata T, Cantley LC, Cohen C, Arbiser JL: AKT1 overexpression in endothelial cells leads to the development of cutaneous vascular malformations in vivo. Arch Dermatol; 2007 Apr;143(4):504-6
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  • [Title] AKT1 overexpression in endothelial cells leads to the development of cutaneous vascular malformations in vivo.
  • The histologic features of these vascular malformations is distinct from ras-transformed MS1 cells (angiosarcoma) and suggest that differing signal abnormalities give rise to human vascular malformations vs malignant vascular tumors.

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  • (PMID = 17438183.001).
  • [ISSN] 0003-987X
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] ENG
  • [Grant] United States / NIGMS NIH HHS / GM / R01 GM041890; United States / NIAMS NIH HHS / AR / P30 AR42687; United States / NIAMS NIH HHS / AR / R01 AR47901
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.11.1 / AKT1 protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt
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41. Puizina-Ivić N, Bezić J, Marasović D, Gotovac V, Carija A, Bozić M: Angiosarcoma arising in sclerodermatous skin. Acta Dermatovenerol Alp Pannonica Adriat; 2005 Mar;14(1):20-5
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  • [Title] Angiosarcoma arising in sclerodermatous skin.
  • We report a case of cutaneous angiosarcoma in a 77-year-old female patient with systemic sclerosis.
  • Since the conservative therapy failed to produce any improvement, a diagnostic skin biopsy was performed.
  • The pathohistological diagnosis was moderately differentiated angiosarcoma.
  • Despite a notable cutaneous improvement, the control check-up revealed the presence of metastases of the lung and liver.
  • This is the first report of cutaneous angiosarcoma occurring in sclerodermatous skin.
  • [MeSH-major] Facial Neoplasms / etiology. Hemangiosarcoma / etiology. Scleroderma, Systemic / complications. Scleroderma, Systemic / physiopathology. Skin Neoplasms / etiology

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  • (PMID = 15818442.001).
  • [ISSN] 1318-4458
  • [Journal-full-title] Acta dermatovenerologica Alpina, Pannonica, et Adriatica
  • [ISO-abbreviation] Acta Dermatovenerol Alp Pannonica Adriat
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Slovenia
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42. Ortiz Mendoza CM: [Recurrent breast haematoma after fine needle aspiration biopsy of angiosarcoma]. Ginecol Obstet Mex; 2007 Mar;75(3):164-7
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  • [Title] [Recurrent breast haematoma after fine needle aspiration biopsy of angiosarcoma].
  • [Transliterated title] Hematoma mamario recidivante posterior a la biopsia por aspiración con aguja delgada en un angiosarcoma.
  • It is reported a rare complication after a fine needle aspiration biopsy of a breast angiosarcoma.
  • A fine needle aspiration biopsy was carried out for diagnosis, but only blood was report.
  • After the biopsy the skin showed a violaceous color, the lump was tender, reappeared in three instances and increased its size (15 cm).
  • Four months later a recurrence presented, and a new excision was carried out with a resulting moderately differentiated angiosarcoma, then a simple mastectomy was performed for definitive treatment.
  • A recurrent haematoma after a fine needle aspiration biopsy of a breast tumor mandates to rule out an angiosarcoma.
  • [MeSH-major] Biopsy, Fine-Needle / adverse effects. Breast / injuries. Breast Neoplasms / pathology. Hemangiosarcoma / pathology. Hematoma / etiology

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  • (PMID = 17547091.001).
  • [ISSN] 0300-9041
  • [Journal-full-title] Ginecología y obstetricia de México
  • [ISO-abbreviation] Ginecol Obstet Mex
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Mexico
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43. Sadhu S, Pattari S, Shaikh F, Verma R, Roy MK: Colonic metastasis from subcutaneous angiosarcoma: A diagnostic dilemma. Indian J Surg; 2010 Jul;72(Suppl 1):328-30
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  • [Title] Colonic metastasis from subcutaneous angiosarcoma: A diagnostic dilemma.
  • Primary angiosarcoma is an extremely rare and aggressive soft-tissue malignancy of endothelial cell origin that occurs most frequently in the skin and subcutaneous tissues of the extremities.
  • Presence of this disease in the intestine as a primary or metastatic deposit is an extremely uncommon incident, and might causes diagnostic confusion with primary colonic neoplasm.
  • We encountered epithelioid angiosarcoma of the sigmoid colon in a 59-year-old male patient who presented with occasional bleeding per rectum and had also had an angiosarcoma arising from the subcutaneous tissue of the right thigh.
  • Retrospective review of histopathology and immunohistochemistry of the two specimens were helpful in the final diagnosis.

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  • (PMID = 23133287.001).
  • [ISSN] 0972-2068
  • [Journal-full-title] The Indian journal of surgery
  • [ISO-abbreviation] Indian J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3451850
  • [Keywords] NOTNLM ; Angiosarcoma / Colonic metastasis
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44. Buschmann A, Lehnhardt M, Toman N, Preiler P, Salakdeh MS, Muehlberger T: Surgical treatment of angiosarcoma of the scalp: less is more. Ann Plast Surg; 2008 Oct;61(4):399-403
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  • [Title] Surgical treatment of angiosarcoma of the scalp: less is more.
  • In 19 patients, we performed a resection of the external table with the defect being covered immediately by a split skin graft.
  • In view of the difficult diagnosis, an often delayed therapy and the rapid formation of metastases, a time-saving procedure with a low rate of complications should be given preference over other reconstructive methods.
  • [MeSH-major] Head and Neck Neoplasms / surgery. Hemangiosarcoma / surgery. Reconstructive Surgical Procedures / methods. Scalp / surgery. Skin Neoplasms / surgery
  • [MeSH-minor] Aged. Aged, 80 and over. Chemotherapy, Adjuvant. Female. Humans. Length of Stay. Male. Neoplasm Recurrence, Local / radiotherapy. Neoplasm Recurrence, Local / surgery. Palliative Care. Radiotherapy, Adjuvant. Skin Transplantation. Wound Healing


45. Nakamura M, Tsushima K, Yasuo M, Yamazaki Y, Honda T, Koizumi T, Fujimoto K, Kubo K: Angiosarcoma with sacral origin metastasizing to the lung. Intern Med; 2006;45(15):923-6
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  • [Title] Angiosarcoma with sacral origin metastasizing to the lung.
  • Specimens obtained by video-assisted thoracic surgery revealed angiosarcoma, but the primary site of angiosarcoma could not be detected before autopsy.
  • Angiosarcoma is a rare malignant neoplasm with rapid proliferation and they can arise at any region of the body.
  • It can originate in the skin, soft tissue, liver or heart.
  • Their multicentric and local recurrence easily leads us to misdiagnosis, and we have struggled to reach diagnosis and its origin.
  • Angiosarcoma should be included in the different diagnosis of diffuse pulmonary hemorrhage with multiple lung nodules.
  • [MeSH-major] Hemangiosarcoma / diagnosis. Lung Neoplasms / diagnosis. Lung Neoplasms / secondary. Sacrum / pathology. Spinal Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Male

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  • (PMID = 16946576.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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46. McAbee KP, Ludwig LL, Bergman PJ, Newman SJ: Feline cutaneous hemangiosarcoma: a retrospective study of 18 cases (1998-2003). J Am Anim Hosp Assoc; 2005 Mar-Apr;41(2):110-6
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  • [Title] Feline cutaneous hemangiosarcoma: a retrospective study of 18 cases (1998-2003).
  • Cutaneous hemangiosarcoma (HSA) has been infrequently reported in dogs and cats.
  • Medical records of 18 cats diagnosed with cutaneous HSA were reviewed.
  • Age at the time of diagnosis, breed, sex, tumor location, tumor size, treatment type, survival time, disease-free interval, and cause of death were evaluated.
  • Cats with cutaneous HSA treated with aggressive surgical excision of their tumors may have a good long-term prognosis.
  • [MeSH-major] Cat Diseases / diagnosis. Cat Diseases / surgery. Hemangiosarcoma / veterinary. Skin Neoplasms / veterinary
  • [MeSH-minor] Animals. Cats. Disease-Free Survival. Female. Male. Neoplasm Recurrence, Local / veterinary. Prognosis. Retrospective Studies. Treatment Outcome


47. Shehan JM, Ahmed I: Angiosarcoma arising in a lymphedematous abdominal pannus with histologic features reminiscent of Kaposi's sarcoma: report of a case and review of the literature. Int J Dermatol; 2006 May;45(5):499-503
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  • [Title] Angiosarcoma arising in a lymphedematous abdominal pannus with histologic features reminiscent of Kaposi's sarcoma: report of a case and review of the literature.
  • BACKGROUND: Despite common endothelial origins, angiosarcoma and Kaposi's sarcoma are clinically and histologically distinct vascular proliferations.
  • The development of angiosarcoma in a chronically edematous abdominal pannus is extremely uncommon.
  • Similarly, tumors with the combined histologic features of angiosarcoma and Kaposi's sarcoma have rarely been described.
  • METHODS: We reviewed the literature on angiosarcoma arising in a lymphedematous abdominal pannus and evaluated an 81-year-old morbidly obese woman who had profound, long-standing edema of the lower abdominal wall in which an aggressive vascular tumor developed.
  • In addition, in our patient, sequential cutaneous sampling from different lesional sites demonstrated disparate histologic changes, ranging from those of classic Kaposi's sarcoma to high-grade angiosarcoma, to areas with combined features of the two tumors.
  • CONCLUSION: It is important to note that angiosarcoma may develop in the abdomen in association with chronic lymphedema, as demonstrated by the cases noted in this report.
  • In addition, our case highlights the difficulty in differentiating histologically angiosarcoma from Kaposi's sarcoma in some situations, and demonstrates the value of close clinicopathologic correlation and sequential tissue sampling in evaluating problematic cases.
  • [MeSH-major] Edema. Hemangiosarcoma / diagnosis. Obesity, Morbid. Skin Neoplasms / diagnosis
  • [MeSH-minor] Abdomen / pathology. Aged. Aged, 80 and over. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Diagnosis, Differential. Fatal Outcome. Female. Humans. Lung Neoplasms / diagnosis. Lung Neoplasms / drug therapy. Lung Neoplasms / secondary. Sarcoma, Kaposi / diagnosis

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  • [CommentIn] Int J Dermatol. 2007 Jun;46(6):662 [17550576.001]
  • (PMID = 16700780.001).
  • [ISSN] 0011-9059
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 21
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48. Hanasono MM, Osborne MP, Dielubanza EJ, Peters SB, Gayle LB: Radiation-induced angiosarcoma after mastectomy and TRAM flap breast reconstruction. Ann Plast Surg; 2005 Feb;54(2):211-4
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  • [Title] Radiation-induced angiosarcoma after mastectomy and TRAM flap breast reconstruction.
  • Radiation-induced angiosarcoma of the breast is being reported with increasing frequency as a result of the increased use of radiation therapy in conjunction with breast conservation surgery.
  • The authors present a case of angiosarcoma occurring in a patient 6 years after undergoing mastectomy for invasive duct carcinoma with immediate transverse rectus abdominis musculocutaneous flap reconstruction followed by postoperative radiation therapy.
  • The diagnosis of angiosarcoma was made by skin biopsy performed by the patient's reconstructive surgeon on routine follow-up examination.
  • This is the first reported case of postradiation angiosarcoma occurring in a postmastectomy breast reconstructed with autogenous tissue and it is unusual in that the cancer invaded the musculocutaneous flap.
  • Diagnosis and management recommendations for radiation-induced angiosarcoma are discussed.
  • [MeSH-major] Breast Neoplasms / surgery. Carcinoma, Ductal, Breast / surgery. Hemangiosarcoma / etiology. Mastectomy, Modified Radical. Neoplasms, Radiation-Induced / surgery

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  • (PMID = 15655476.001).
  • [ISSN] 0148-7043
  • [Journal-full-title] Annals of plastic surgery
  • [ISO-abbreviation] Ann Plast Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ki-67 Antigen
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49. Liu J, Waalkes MP: Liver is a target of arsenic carcinogenesis. Toxicol Sci; 2008 Sep;105(1):24-32
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  • Inorganic arsenic is clearly a human carcinogen causing tumors of the skin, lung, urinary bladder, and possibly liver (IARC, 2004).
  • Hepatocellular carcinoma and hepatic angiosarcoma, have been frequently associated with environmental or medicinal exposure to arsenicals.
  • Chronic exposure of rat liver epithelial cells to low concentrations of inorganic arsenic induces malignant transformation, producing aggressive, undifferentiated epithelial tumors when inoculated into the Nude mice.

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  • (PMID = 18566022.001).
  • [ISSN] 1096-0929
  • [Journal-full-title] Toxicological sciences : an official journal of the Society of Toxicology
  • [ISO-abbreviation] Toxicol. Sci.
  • [Language] ENG
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Estrogens; N712M78A8G / Arsenic
  • [Number-of-references] 86
  • [Other-IDs] NLM/ PMC2734307
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50. Gao Z, Chen S: Postradiation angiosarcoma of the skin featuring capillary lobules. Am J Dermatopathol; 2006 Aug;28(4):376
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  • [Title] Postradiation angiosarcoma of the skin featuring capillary lobules.
  • [MeSH-major] Hemangiosarcoma / blood supply. Hemangiosarcoma / pathology

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  • [CommentOn] Am J Dermatopathol. 2005 Aug;27(4):301-5 [16121049.001]
  • (PMID = 16871048.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Comment; Letter
  • [Publication-country] United States
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51. Sparsa A, Liozon E, Wechsler J, Soria P, Delage-Core M, Loustaud V, Bedane C, Bonnetblanc JM, Vidal E: Aortic angiosarcoma clinically mimicking polyarteritis nodosa. Scand J Rheumatol; 2006 May-Jun;35(3):237-40
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  • [Title] Aortic angiosarcoma clinically mimicking polyarteritis nodosa.
  • We report two patients in whom angiosarcoma of the aorta (ASA) with distal emboli and skin metastases was initially clinically misdiagnosed as polyarteritis nodosa (PAN).
  • Both presented with features highly suggestive of systemic necrotizing vasculitis, including constitutional symptoms, orchitis (in one), leg pain with sensory neuropathy, livedo, focal areas of skin necrosis, painful cutaneous nodules demonstrating vasculitis or inconspicuous changes on biopsy, raised acute phase reactants, and transient improvement with systemic corticosteroids.
  • Repeated skin biopsies revealed an atypical endovascular cell proliferation with strong reactivity for factor VIII.
  • [MeSH-major] Aortic Diseases / diagnosis. Hemangiosarcoma / diagnosis. Polyarteritis Nodosa / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Male. Middle Aged. Neoplastic Cells, Circulating. Skin Neoplasms / secondary

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  • (PMID = 16766373.001).
  • [ISSN] 0300-9742
  • [Journal-full-title] Scandinavian journal of rheumatology
  • [ISO-abbreviation] Scand. J. Rheumatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Norway
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52. Lahat G, Dhuka AR, Lahat S, Smith KD, Pollock RE, Hunt KK, Ravi V, Lazar AJ, Lev D: Outcome of locally recurrent and metastatic angiosarcoma. Ann Surg Oncol; 2009 Sep;16(9):2502-9
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  • [Title] Outcome of locally recurrent and metastatic angiosarcoma.
  • BACKGROUND: Angiosarcoma (AS) is a rare soft tissue sarcoma with an enhanced propensity for local and systemic failure.
  • RESULTS: Forty-four patients were treated for locally recurrent AS; the majority (59%) were <or=5 cm; the most common sites were skin (48%) and breast (32%).
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Hemangiosarcoma / secondary. Neoplasm Recurrence, Local / pathology. Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Combined Modality Therapy. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. Prognosis. Radiotherapy Dosage. Retrospective Studies. Survival Rate. Treatment Outcome. Young Adult

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  • (PMID = 19551444.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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53. Conde-Taboada A, Flórez A, De la Torre C, Feal C, García-Doval I, Cruces M: Pseudoangiosarcomatous squamous cell carcinoma of skin arising adjacent to decubitus ulcers. Am J Dermatopathol; 2005 Apr;27(2):142-4
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  • [Title] Pseudoangiosarcomatous squamous cell carcinoma of skin arising adjacent to decubitus ulcers.
  • Pseudoangiosarcomatous, or pseudovascular, squamous cell carcinoma of skin is an unusual form of acantholytic (adenoid, pseudoglandular) squamous cell carcinoma that mimics the histolopathologic appearance of angiosarcoma.
  • The histopathologic examination of a wedge biopsy specimen revealed infiltrative cords of neoplastic cells that formed interanastomosing channels imitating angiosarcoma.
  • To our knowledge, our patient is the first with pseudoangiosarcomatous squamous cell carcinoma of skin developing within decubitus ulcer.
  • [MeSH-major] Carcinoma, Squamous Cell / complications. Pressure Ulcer / complications. Skin Neoplasms / complications
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Hemangiosarcoma / pathology. Humans. Immunohistochemistry

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  • (PMID = 15798440.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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54. Tsolakis I, Lampropoulos G, Zolota V, Papadoulas S, Christeas N: Aortic angiosarcoma with cutaneous metastases. Vascular; 2009 May-Jun;17(3):176-80
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  • [Title] Aortic angiosarcoma with cutaneous metastases.
  • The diagnosis of aortic angiosarcoma is usually confirmed by postoperative histopathologic examination or postmortem study.
  • We present a case of primary aortic angiosarcoma presenting with intermittent claudication and radiologic findings of aortoiliac atherosclerotic disease treated initially with stenting; lower extremity embolic skin metastases developed during follow-up that prompted resection of the aortic bifurcation and restoration of the arterial continuity with a bypass.
  • [MeSH-major] Aortic Diseases / diagnostic imaging. Foot Diseases / etiology. Hemangiosarcoma / diagnostic imaging. Skin Neoplasms / secondary

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  • (PMID = 19476753.001).
  • [ISSN] 1708-5381
  • [Journal-full-title] Vascular
  • [ISO-abbreviation] Vascular
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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55. Chen W, Shih CS, Wang YT, Tseng GC, Hsu WH: Angiosarcoma with pulmonary metastasis presenting with spontaneous bilateral pneumothorax in an elderly man. J Formos Med Assoc; 2006 Mar;105(3):238-41
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  • [Title] Angiosarcoma with pulmonary metastasis presenting with spontaneous bilateral pneumothorax in an elderly man.
  • Cutaneous angiosarcoma is a rare and invasive endothelial-derived sarcoma that occurs most frequently in the scalp and facial skin of elderly men.
  • We report a case of angiosarcoma of the scalp with cystic metastasis to the lung in a 63-year-old man, presenting as recurrent bilateral spontaneous pneumothorax.
  • Pneumothorax in the elderly should be differentiated from malignant metastatic lung tumors.

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  • (PMID = 16520841.001).
  • [ISSN] 0929-6646
  • [Journal-full-title] Journal of the Formosan Medical Association = Taiwan yi zhi
  • [ISO-abbreviation] J. Formos. Med. Assoc.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
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56. Devillers C, Vanhooteghem O, de la Brassinne M: [Lymphedema and cutaneous diseases]. Rev Med Suisse; 2007 Dec 5;3(136):2802-5
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  • [Title] [Lymphedema and cutaneous diseases].
  • Clinical changes of skin can occur.
  • The major cutaneous complications are infections, dysimmune diseases and neoplasms; the most serious is angiosarcoma.
  • [MeSH-major] Lymphedema / complications. Skin Diseases / etiology
  • [MeSH-minor] Dermatomycoses / etiology. Erysipelas / etiology. Hemangiosarcoma. Humans. Intertrigo / microbiology. Pemphigoid, Bullous / etiology. Skin Neoplasms / etiology. Sweet Syndrome / etiology

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  • (PMID = 18183816.001).
  • [ISSN] 1660-9379
  • [Journal-full-title] Revue médicale suisse
  • [ISO-abbreviation] Rev Med Suisse
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Switzerland
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57. Pfeiffer DF, Bode-Lesniewska B: Fine needle aspiration biopsy diagnosis of angiosarcoma after breast-conserving therapy for carcinoma supported by use of a cell block and immunohistochemistry. Acta Cytol; 2006 Sep-Oct;50(5):553-6
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  • [Title] Fine needle aspiration biopsy diagnosis of angiosarcoma after breast-conserving therapy for carcinoma supported by use of a cell block and immunohistochemistry.
  • BACKGROUND: Angiosarcoma is a rare malignant soft tissue tumor occurring at various sites as either a primary or secondary event.
  • Primary angiosarcoma of the breast is an unusual tumor, counting for 1 in 1700-2,000 primary malignant tumors of this organ.
  • An increasing number of secondary angiosarcomas involving skin and breast.
  • CASE: Angiosarcoma arose 6 years after breast-conserving therapy for invasive carcinoma in a 69-year-old woman.
  • Fine needle aspiration of several small, reddish, intradermal nodules over the treated area revealed malignant cells with an endothelial immunophenotype in the cel block, yielding the diagnosis of angiosarcoma, subsequently confired in a mastectomy speciman.
  • CONCLUSION: Fine needle aspiration, supported by ancillary techniques, such as cell block and immunohistochemistry, allows the cytologic diagnosis of an angiosarcoma and differentiates it from a carcinoma recurrence.
  • [MeSH-major] Breast / pathology. Breast Neoplasms / diagnosis. Carcinoma, Ductal, Breast / diagnosis. Hemangiosarcoma / diagnosis. Neoplasms, Second Primary / diagnosis. Radiotherapy / adverse effects
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Biomarkers, Tumor / metabolism. Biopsy, Fine-Needle. Cell Nucleus / pathology. Diagnosis, Differential. Epithelial Cells / pathology. Female. Humans. Immunohistochemistry / methods. Neoplasm Recurrence, Local / diagnosis

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  • (PMID = 17017445.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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58. Leggio L, Addolorato G, Abenavoli L, Ferrulli A, D'Angelo C, Mirijello A, Vonghia L, Schinzari G, Arena V, Perrone L, Citterio F, Bonomo L, Rapaccini GL, Capelli A, Barone C, Gasbarrini G: Primary renal angiosarcoma: a rare malignancy. A case report and review of the literature. Urol Oncol; 2006 Jul-Aug;24(4):307-12
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  • [Title] Primary renal angiosarcoma: a rare malignancy. A case report and review of the literature.
  • Angiosarcoma is a rare malignant tumor occurring in less than 2% of soft tissue sarcomas.
  • Angiosarcoma involving the kidney usually represents metastasis from skin or visceral primary lesions, while angiosarcoma primarily occurring in the kidney is a very rare neoplasm.
  • In the English literature, from 1942 to the present, only 19 cases of primary kidney angiosarcoma have been reported.
  • A case of primary renal angiosarcoma presenting as a large kidney mass and flank pain occurring after traumatism is reported.
  • [MeSH-major] Hemangiosarcoma / pathology. Kidney Neoplasms / pathology

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  • (PMID = 16818182.001).
  • [ISSN] 1078-1439
  • [Journal-full-title] Urologic oncology
  • [ISO-abbreviation] Urol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 28
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59. Nagano T, Yamada Y, Ikeda T, Kanki H, Kamo T, Nishigori C: Docetaxel: a therapeutic option in the treatment of cutaneous angiosarcoma: report of 9 patients. Cancer; 2007 Aug 1;110(3):648-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Docetaxel: a therapeutic option in the treatment of cutaneous angiosarcoma: report of 9 patients.
  • BACKGROUND: Effective treatment options are limited for patients with cutaneous angiosarcoma (AS).
  • Another taxane drug, paclitaxel, reportedly had unique activity in the treatment of AS of the scalp and neck and acquired immunodeficiency syndrome-related Kaposi sarcoma.
  • Therefore, the authors hypothesized that docetaxel may be of value in the treatment of cutaneous AS that is resistant to conventional therapy.
  • This treatment regimen was received by 9 patients with cutaneous AS who were treated at Kobe University Hospital between January 2003 and October 2006.
  • CONCLUSIONS: The current study demonstrated that docetaxel was effective in patients with cutaneous AS.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Hemangiosarcoma / drug therapy. Skin Neoplasms / drug therapy. Taxoids / therapeutic use

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  • [Copyright] (c) 2007 American Cancer Society.
  • (PMID = 17582627.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Taxoids; 15H5577CQD / docetaxel
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60. Lucas DR: Angiosarcoma, radiation-associated angiosarcoma, and atypical vascular lesion. Arch Pathol Lab Med; 2009 Nov;133(11):1804-9
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  • [Title] Angiosarcoma, radiation-associated angiosarcoma, and atypical vascular lesion.
  • Angiosarcoma, one of the least common sarcomas, has become increasingly important because of its association with radiation therapy, especially for breast cancer.
  • Most are sporadic, presenting as cutaneous tumors in the scalp/face of elderly patients.
  • However, angiosarcoma has a wide anatomic distribution including soft tissue, visceral organ, and osseous locations.
  • Radiation-associated angiosarcoma typically presents as a cutaneous tumor several years posttherapy.
  • The latency for radiation-associated mammary angiosarcoma is relatively short, sometimes less than 3 years.
  • Atypical vascular lesion refers to a small, usually lymphatic-type vascular proliferation in radiated skin.
  • Although most atypical vascular lesions pursue a benign course, they recur and very rarely progress to angiosarcoma.
  • Distinguishing this lesion from well-differentiated angiosarcoma in a biopsy can be challenging, especially because areas indistinguishable from atypical vascular lesion are found adjacent to angiosarcoma.
  • [MeSH-major] Hemangioma / pathology. Hemangiosarcoma / pathology. Neoplasms, Radiation-Induced / pathology. Skin Neoplasms / pathology. Vascular Diseases / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Breast Neoplasms / radiotherapy. Female. Humans. Skin / blood supply

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  • (PMID = 19886715.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 12
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61. Chen SY, Takeuchi S, Urabe K, Hayashida S, Kido M, Tomoeda H, Uchi H, Dainichi T, Takahara M, Shibata S, Tu YT, Furue M, Moroi Y: Overexpression of phosphorylated-ATF2 and STAT3 in cutaneous angiosarcoma and pyogenic granuloma. J Cutan Pathol; 2008 Aug;35(8):722-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Overexpression of phosphorylated-ATF2 and STAT3 in cutaneous angiosarcoma and pyogenic granuloma.
  • BACKGROUND: Activating transcription factor-2/Activator protein-1 (AP-1), Signal transducer and activator of transcription-3 and p53 are important regulators of cellular proliferation, apoptosis, differentiation in the pathogenesis of many human tumors, but the expression of phosphorylated (p)-activating transcription factor-2 (p-ATF2), phosphorylated (p)-signal transducer and activator of transcription-3 (p-STAT3) and p53 family (p63 and p73) has not been investigated in cutaneous angiosarcoma (CAS) and pyogenic granuloma (PG) so far.
  • OBJECTIVES: To investigate the expression of p-ATF2, p-STAT3 and p53 and its family in cutaneous vascular tumors (CAS and PG).
  • The p-ATF2-, p-STAT3- and p53 expression (% positive cells) in CAS and PG were significantly higher than in normal dermal vessels, but none of these transcription factors distinguished malignant (CAS)- from benign (PG) vascular tumor.
  • CONCLUSIONS: The present study suggests that overexpression of p-ATF2, p-STAT3 and possibly p53, but not p63 or p73, may contribute to the tumorigenesis of cutaneous vascular tumors.
  • [MeSH-major] Activating Transcription Factor 2 / biosynthesis. Gene Expression Regulation, Neoplastic. Granuloma, Pyogenic / metabolism. Hemangiosarcoma / metabolism. STAT3 Transcription Factor / biosynthesis. Skin Neoplasms / metabolism. Tumor Suppressor Protein p53 / biosynthesis


62. Bernathova M, Jaschke W, Pechlahner C, Zelger B, Bodner G: Primary angiosarcoma of the breast associated Kasabach-Merritt syndrome during pregnancy. Breast; 2006 Apr;15(2):255-8
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  • [Title] Primary angiosarcoma of the breast associated Kasabach-Merritt syndrome during pregnancy.
  • Primary angiosarcoma of the breast is a rare aggressive tumour of unknown etiology.
  • A frequent clinical presentation is a painful palpable smooth mass or diffuse enlargement of the breast without a palpable mass but with purple discolouration of the overlying skin with apparent bruising.
  • An uncommon clinical presentation of an angiosarcoma is spontaneous bleeding due to disseminated intravascular coagulation (DIC) by consumption coagulopathy, known as the Kasabach-Merritt syndrome.
  • Imaging characteristics of a breast angiosarcoma are limited to a few radiological reports.
  • We report a case of a young pregnant woman with a bleeding angiosarcoma of the breast and associated Kasabach-Merritt syndrome and describe the sonographic and MRI findings.
  • [MeSH-major] Breast Neoplasms / diagnosis. Disseminated Intravascular Coagulation / diagnosis. Hemangiosarcoma / diagnosis. Pregnancy Complications, Hematologic / diagnosis. Pregnancy Complications, Neoplastic / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Pregnancy. Pregnancy Trimester, Second. Prenatal Diagnosis. Syndrome

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  • (PMID = 16000250.001).
  • [ISSN] 0960-9776
  • [Journal-full-title] Breast (Edinburgh, Scotland)
  • [ISO-abbreviation] Breast
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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63. Bhutoria B, Konar A, Chakrabarti S, Das S: Retiform hemangioendothelioma with lymph node metastasis: a rare entity. Indian J Dermatol Venereol Leprol; 2009 Jan-Feb;75(1):60-2
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  • Retiform hemangioendothelioma (RH) is a rare, recently described, unique kind of low grade angiosarcoma.
  • The tumor chiefly originates from the skin and subcutaneous tissue and has a tendency to recur locally.
  • [MeSH-major] Hemangioendothelioma / diagnosis. Hemangioendothelioma / pathology. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / pathology

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  • (PMID = 19172034.001).
  • [ISSN] 0973-3922
  • [Journal-full-title] Indian journal of dermatology, venereology and leprology
  • [ISO-abbreviation] Indian J Dermatol Venereol Leprol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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64. Lazova R, McNiff JM, Glusac EJ, Godic A: Promontory sign--present in patch and plaque stage of angiosarcoma! Am J Dermatopathol; 2009 Apr;31(2):132-6
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  • [Title] Promontory sign--present in patch and plaque stage of angiosarcoma!
  • Kaposi sarcoma is characterized by a proliferation of irregular jagged vascular channels, which partly surround preexisting blood vessels in some areas.
  • Cutaneous angiosarcoma (AS) is a malignant vascular neoplasm comprised of a meshwork of anastomosing irregular dilated vessels between collagen bundles and around skin appendages, lined by atypical endothelial cells.
  • We retrieved all cases of cutaneous AS from the files of Yale Dermatopathology Laboratory between 1990 and 2007.
  • The lesions were divided histologically in a patch, plaque, or tumor stage according to the depth of invasion of malignant cells.
  • The presence of promontory sign has not been emphasized in lesions other than Kaposi sarcoma, but seems to be a feature that is not uncommon in patch/plaque stage AS.
  • [MeSH-major] Dermis / pathology. Endothelial Cells / pathology. Hemangiosarcoma / pathology. Sarcoma, Kaposi / pathology. Skin Neoplasms / pathology

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  • (PMID = 19318797.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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65. Jain M, Singh S, Agarwal K: Spindle cell neoplasm of skin: diagnostic dilemma. Indian J Pathol Microbiol; 2007 Oct;50(4):814-6
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  • [Title] Spindle cell neoplasm of skin: diagnostic dilemma.
  • Poorly differentiated, spindle cell malignancies, on sun damaged skin frequently pose a diagnostic challenge for pathologists.
  • The vast majority of these neoplasms ultimately are diagnosed as either atypical fibroxanthoma (AFX), spindle cell melanoma (SCM), and very rarely as spindle cell squamous cell carcinoma (SCSCC), leiomyosarcoma or angiosarcoma.
  • Light microscopic clues may suggest one of these neoplasms, but subtle and overlapping characteristics often render precise diagnosis impossible based on morphological features alone.
  • Immunohistochemistry therefore is necessary to firmly and accurately diagnose the majority of spindle cell malignancies on sun damaged skin.
  • [MeSH-major] Sarcoma / diagnosis. Sarcoma / pathology. Skin Neoplasms / diagnosis. Skin Neoplasms / pathology
  • [MeSH-minor] Aged, 80 and over. Carcinoma, Squamous Cell / pathology. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Keratins / analysis. Melanoma / pathology. S100 Proteins / analysis. Vimentin / analysis. Xanthomatosis / pathology

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  • (PMID = 18306566.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / S100 Proteins; 0 / Vimentin; 68238-35-7 / Keratins
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66. Williams SB, Reed M: Cutaneous angiosarcoma after breast conserving treatment for bilateral breast cancers in a BRCA-1 gene mutation carrier--a case report and review of the literature. Surgeon; 2009 Aug;7(4):250
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  • [Title] Cutaneous angiosarcoma after breast conserving treatment for bilateral breast cancers in a BRCA-1 gene mutation carrier--a case report and review of the literature.
  • [MeSH-major] Breast Neoplasms / genetics. Genes, BRCA1. Hemangiosarcoma / genetics. Hemangiosarcoma / pathology. Skin Neoplasms / genetics. Skin Neoplasms / pathology

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  • (PMID = 19736894.001).
  • [ISSN] 1479-666X
  • [Journal-full-title] The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
  • [ISO-abbreviation] Surgeon
  • [Language] eng
  • [Publication-type] Case Reports; Letter; Review
  • [Publication-country] Scotland
  • [Number-of-references] 5
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67. Kunkel T, Mylonas I, Mayr D, Friese K, Sommer HL: Recurrence of secondary angiosarcoma in a patient with post-radiated breast for breast cancer. Arch Gynecol Obstet; 2008 Nov;278(5):497-501
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  • [Title] Recurrence of secondary angiosarcoma in a patient with post-radiated breast for breast cancer.
  • INTRODUCTION: Angiosarcoma of the breast is a rare finding.
  • Two different subtypes of angiosarcomas have been described: (a) the Stewart-Treves syndrome and (b) the cutaneous post-radiation angiosarcoma.
  • We report a case where both types of angiosarcoma occurred.
  • CASE REPORT: At first, an angiosarcoma affecting parenchyma of the breast was observed after radiotherapy following breast conserving therapy and a history of lymphoedema of the radiated area.
  • Additionally, a subsequent local recurrence of the angiosarcoma of the skin after mastectomy and complete resection of the primary angiosarcoma was diagnosed.
  • Patients should be pointed to this possible complication of radiotherapy and transferred to seek medical advice immediately in case of skin lesion in the irradiated area: even many years after radiotherapy.
  • Additionally, every oncologist should be aware of this rare complication as quick diagnosis and prompt surgical treatment is indispensable due to the aggressive entity of angiosarcoma.
  • [MeSH-major] Breast Neoplasms / therapy. Hemangiosarcoma / therapy. Neoplasm Recurrence, Local / therapy. Skin Neoplasms / therapy

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  • (PMID = 18305948.001).
  • [ISSN] 0932-0067
  • [Journal-full-title] Archives of gynecology and obstetrics
  • [ISO-abbreviation] Arch. Gynecol. Obstet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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68. Asgari MM, Cockerell CJ, Weitzul S: The head-tilt maneuver: a clinical aid in recognizing head and neck angiosarcomas. Arch Dermatol; 2007 Jan;143(1):75-7
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  • BACKGROUND: Cutaneous angiosarcoma is a rare, life-threatening tumor that is often initially misdiagnosed.
  • This delay in diagnosis can affect tumor growth, metastatic potential, and prognosis.
  • [MeSH-major] Head Movements. Head and Neck Neoplasms / diagnosis. Hemangiosarcoma / diagnosis. Skin / pathology
  • [MeSH-minor] Diagnosis, Differential. Face. Head-Down Tilt. Humans. Male. Torsion Abnormality

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  • (PMID = 17224545.001).
  • [ISSN] 0003-987X
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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69. Boswell JS, Davis MD: Violaceous plaque on the forehead clinically resembling angiosarcoma: cutaneous metastasis in a patient with prostatic adenocarcinoma. J Am Acad Dermatol; 2005 Oct;53(4):744-5
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  • [Title] Violaceous plaque on the forehead clinically resembling angiosarcoma: cutaneous metastasis in a patient with prostatic adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / secondary. Hemangiosarcoma / diagnosis. Prostatic Neoplasms / pathology. Skin Neoplasms / secondary

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  • (PMID = 16198815.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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70. Kisseberth WC, Vail DM, Yaissle J, Jeglum KA, Couto CG, Ward H, Khanna C, Obradovich JE: Phase I clinical evaluation of carboplatin in tumor-bearing cats: a Veterinary Cooperative Oncology Group study. J Vet Intern Med; 2008 Jan-Feb;22(1):83-8
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  • There was 1 complete response (cutaneous hemangiosarcoma) and 6 partial responses (4 injection site sarcomas, 1 oral squamous cell carcinoma, 1 lymphoma).

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  • (PMID = 18289293.001).
  • [ISSN] 0891-6640
  • [Journal-full-title] Journal of veterinary internal medicine
  • [ISO-abbreviation] J. Vet. Intern. Med.
  • [Language] ENG
  • [Publication-type] Clinical Trial, Phase I; Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; AYI8EX34EU / Creatinine; BG3F62OND5 / Carboplatin
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71. Brenn T, Fletcher CD: Postradiation vascular proliferations: an increasing problem. Histopathology; 2006 Jan;48(1):106-14
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  • The occurrence of cutaneous vascular lesions is a rare but well-documented complication of radiation treatment and may be associated with significant morbidity as well as mortality.
  • The spectrum of postradiation vascular lesions is wide and ranges from atypical vascular lesions with reportedly benign clinical behaviour to frank cutaneous angiosarcoma.
  • [MeSH-major] Hemangiosarcoma / pathology. Neoplasms, Radiation-Induced / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Skin / blood supply. Skin / pathology. Skin / radiation effects

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  • (PMID = 16359542.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 80
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72. Park JW, Serafica-Karen C, Das K: Fine-needle aspiration of metastatic radiation-induced cutaneous epithelioid angiosarcoma of the breast to the liver: A diagnostic dilemma. Diagn Cytopathol; 2010 Oct;38(10):768-71
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  • [Title] Fine-needle aspiration of metastatic radiation-induced cutaneous epithelioid angiosarcoma of the breast to the liver: A diagnostic dilemma.
  • Radiation therapy is a significant risk factor for the development of angiosarcoma.
  • With the increase in breast conservation treatment, the incidence of cutaneous radiation-induced angiosarcoma of the breast is rising.
  • If the angiosarcoma demonstrates epithelioid features, the tumor cells may present a diagnostic dilemma on fine-needle aspiration cytology.
  • We present a case of metastatic radiation-induced cutaneous epithelioid angiosarcoma of the breast to the liver and a review of the literature.
  • [MeSH-minor] Breast Neoplasms / metabolism. Breast Neoplasms / secondary. Carcinoma in Situ / radiotherapy. Carcinoma in Situ / surgery. Carcinoma, Ductal, Breast / radiotherapy. Carcinoma, Ductal, Breast / surgery. Cytodiagnosis. Diagnosis, Differential. Female. Hemangiosarcoma / metabolism. Hemangiosarcoma / secondary. Humans. Immunohistochemistry. Mastectomy, Segmental. Middle Aged. Radiotherapy, Adjuvant / adverse effects. Skin Neoplasms / metabolism. Skin Neoplasms / pathology

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  • [Copyright] © 2010 Wiley-Liss, Inc.
  • (PMID = 20187111.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] Angiosarcoma of the breast
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73. Forton GE, Van Parys G, Hertveldt K: Primary angiosarcoma of the non-irradiated parotid gland: a most uncommon, highly malignant tumor. Eur Arch Otorhinolaryngol; 2005 Mar;262(3):173-7
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  • [Title] Primary angiosarcoma of the non-irradiated parotid gland: a most uncommon, highly malignant tumor.
  • This case report discusses the clinical presentation, imaging, surgery and further treatment and course of a primary angiosarcoma of a non-irradiated parotid gland.
  • [MeSH-major] Hemangiosarcoma / secondary. Parotid Neoplasms / pathology. Skin Neoplasms / secondary
  • [MeSH-minor] Aged. Aged, 80 and over. Antigens, CD45 / immunology. Humans. Keratins / immunology. Magnetic Resonance Imaging. Male. Neoplasm Staging. Neoplasms, Second Primary / diagnostic imaging. Neoplasms, Second Primary / pathology. Tomography, X-Ray Computed

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  • [Cites] Head Neck. 1992 Jan-Feb;14(1):1-7 [1624288.001]
  • [Cites] Histopathology. 1998 Dec;33(6):586-7 [9870161.001]
  • [Cites] Mod Pathol. 2003 Mar;16(3):263-71 [12640107.001]
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  • (PMID = 15133686.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 68238-35-7 / Keratins; EC 3.1.3.48 / Antigens, CD45
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74. Kaminaka C, Yamamoto Y, Yonei N, Furukawa F: Phenol application to angiosarcomas: implications and histologic studies. Int J Dermatol; 2009 May;48(5):470-5
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  • BACKGROUND: Cutaneous angiosarcoma (AS) is an aggressive endothelial sarcoma that arises in elderly people.
  • AIMS: To evaluate the efficacy of phenol application for the treatment of AS, and to examine the histologic changes in three cases of cutaneous AS with phenol application.
  • METHODS: After phenol application, biopsy specimens were collected from three patients with cutaneous AS.
  • Paraffin-embedded sections of the skin specimens were then stained with hematoxylin and eosin.
  • [MeSH-major] Hemangiosarcoma / drug therapy. Hemangiosarcoma / pathology. Phenol / therapeutic use. Sclerosing Solutions / therapeutic use. Skin Neoplasms / drug therapy. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Apoptosis / drug effects. Biopsy. Female. Humans. In Situ Nick-End Labeling. Skin / pathology

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  • (PMID = 19416375.001).
  • [ISSN] 1365-4632
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Sclerosing Solutions; 339NCG44TV / Phenol
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75. Tokyol C, Demir Y, Aktepe F: Cutaneous intravascular papillary endothelial hyperplasia of the hand: a case report and review of the literature. Turk J Pediatr; 2005 Jan-Mar;47(1):71-4
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  • [Title] Cutaneous intravascular papillary endothelial hyperplasia of the hand: a case report and review of the literature.
  • Intravascular papillary endothelial hyperplasia (IPEH) is a rare benign endothelial proliferation that bears a remarkable resemblance to angiosarcoma.
  • We report a case of cutaneous IPEH in the thumb of a seven-year old girl which was successfully treated with excision.
  • The relevant literature is reviewed and histopathological features, differential diagnosis and natural history of the lesion are discussed.
  • [MeSH-major] Endothelium, Vascular / pathology. Hyperplasia / diagnosis
  • [MeSH-minor] Child. Diagnosis, Differential. Female. Hemangiosarcoma / diagnosis. Humans. Skin Neoplasms / pathology. Thumb / pathology. Treatment Outcome

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  • (PMID = 15884634.001).
  • [ISSN] 0041-4301
  • [Journal-full-title] The Turkish journal of pediatrics
  • [ISO-abbreviation] Turk. J. Pediatr.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Turkey
  • [Number-of-references] 17
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76. Maeda T, Uchino K, Otani T, Ueda Y: [Cutaneous angiosarcoma with difficulty in differential diagnosis of thrombocytopenia]. Rinsho Ketsueki; 2010 Jun;51(6):402-6
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  • [Title] [Cutaneous angiosarcoma with difficulty in differential diagnosis of thrombocytopenia].
  • An 87-year-old man was referred to our hospital because of sustained bleeding from head skin lesions after trauma.
  • Based on the tentative diagnosis of immune thrombocytopenic purpura (ITP), immunosuppressive drugs and high-dose immunoglobulin were administered; however, the platelet count did not recover, and was followed by severe DIC, resulting in a fatal outcome due to massive bleeding from the scalp.
  • Histopathological examination of autopsy samples of skin lesions revealed angiosarcoma, suggesting that Kasabach-Merritt syndrome (KMS) complicated with DIC, but not ITP, was the primary cause of thrombocytopenia.
  • Although KMS is commonly accompanied with hemangioma in infants, it is extremely rare in patients with angiosarcoma, which is an uncommon malignant neoplasm.
  • In this case, our correct diagnosis of thrombocytopenia was difficult because of the unusual clinical setting, indicating that careful interpretation of physical, laboratory and pathological examinations is mandatory for correct diagnosis of thrombocytopenia of unknown etiology.
  • [MeSH-major] Hemangiosarcoma / complications. Hemangiosarcoma / diagnosis. Skin Neoplasms / complications. Skin Neoplasms / diagnosis. Thrombocytopenia / diagnosis. Thrombocytopenia / etiology
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. Disseminated Intravascular Coagulation / etiology. Fatal Outcome. Hemangioma / complications. Humans. Male. Syndrome

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  • (PMID = 20622486.001).
  • [ISSN] 0485-1439
  • [Journal-full-title] [Rinshō ketsueki] The Japanese journal of clinical hematology
  • [ISO-abbreviation] Rinsho Ketsueki
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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77. Martorell-Calatayud A, Balmer N, Sanmartín O, Díaz-Recuero JL, Sangueza OP: Definition of the features of acquired elastotic hemangioma reporting the clinical and histopathological characteristics of 14 patients. J Cutan Pathol; 2010 Apr;37(4):460-4
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  • BACKGROUND: During the last few years, new cutaneous vascular proliferations have been described, including a distinctive clinicopathologic variant of hemangioma, denominated acquired elastotic hemangioma.
  • RESULTS: Acquired elastotic hemangioma affects sun-damaged skin of upper extremities and neck.
  • CONCLUSION: Acquired elastotic hemangioma is a distinctive variant of hemangioma which should be differentiated from other cutaneous vascular tumors with a hobnail endothelial pattern, including angiosarcoma.
  • [MeSH-major] Blood Vessels / pathology. Hemangioma / pathology. Skin / pathology. Skin Neoplasms / pathology

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  • (PMID = 19615005.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Biomarkers, Tumor
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78. Znati K, Daoudi A, Chbani L, Elfatemi H, Harmouch T, Bouteyeb F, Amarti A: [Intravascular papillary endothelial hyperplasia of the ankle: a case report]. Ann Chir Plast Esthet; 2009 Dec;54(6):600-2
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  • This lesion has the propensity to occur in the skin and the subcutis.
  • Many histological features are similar to those of low-grade angiosarcoma, a common, but more serious condition.
  • We report a case of cutaneous IPEH in the ankle of a 30-year-old girl, which was successfully treated by excision.
  • The pathologic findings, differential diagnosis and a review of recent literature are discussed.
  • [MeSH-minor] Adult. Diagnosis, Differential. Endothelium, Vascular / pathology. Female. Humans. Hyperplasia / pathology. Treatment Outcome

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  • (PMID = 19443095.001).
  • [ISSN] 1768-319X
  • [Journal-full-title] Annales de chirurgie plastique et esthétique
  • [ISO-abbreviation] Ann Chir Plast Esthet
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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79. Fernandez-Flores A, Rodriguez R: Promontory sign in a reactive benign vascular proliferation. Am J Dermatopathol; 2010 Oct;32(7):700-3
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  • The promontory sign was described 27 years ago and it was claimed to be useful in the diagnosis of early stages of Kaposi sarcoma.
  • However, it is not pathognomonic, because it has also been described in angiosarcoma and in benign vascular tumors.
  • We report the case of a vascular cutaneous lesion on the breast of a 75-year-old woman, which had a benign clinical behavior, and presented with the promontory sign.
  • [MeSH-major] Breast Diseases / pathology. Skin Diseases / pathology. Vascular Diseases / pathology
  • [MeSH-minor] Aged. Blood Vessels / pathology. Breast Neoplasms / pathology. Cardiomyopathy, Hypertrophic / complications. Diagnosis, Differential. Female. Humans. Hypothyroidism / complications

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  • (PMID = 20577080.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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80. Vogt T: [Angiosarcoma]. Hautarzt; 2008 Mar;59(3):237-48; quiz 249-50
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  • [Title] [Angiosarcoma].
  • [Transliterated title] Angiosarkom.
  • Angiosarcoma favors superficial soft tissues and skin (60%) with a clear predilection for the head and neck region.
  • The average age of the patients presenting with cutaneous angiosarcomas is around 70 years with a peak incidence in the 8th decade.
  • Secondary angiosarcoma after tissue-conserving radiation therapy for carcinoma of the breast represents an increasing problem, both the differentiation between atypical vascular lesions and true aggressive angiosarcoma and the therapy are challenging.
  • The prognosis for angiosarcoma patients is gloomy despite all therapeutic efforts.
  • [MeSH-major] Hemangiosarcoma / diagnosis. Hemangiosarcoma / therapy. Skin Neoplasms / diagnosis. Skin Neoplasms / therapy

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  • (PMID = 18273583.001).
  • [ISSN] 1432-1173
  • [Journal-full-title] Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
  • [ISO-abbreviation] Hautarzt
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 27
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81. Di Tommaso L, Rosai J: The capillary lobule: a deceptively benign feature of post-radiation angiosarcoma of the skin: report of three cases. Am J Dermatopathol; 2005 Aug;27(4):301-5
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  • [Title] The capillary lobule: a deceptively benign feature of post-radiation angiosarcoma of the skin: report of three cases.
  • Three cases are presented of a proliferative vascular lesion of the skin developing in the chest wall of women who had received radiation therapy for breast carcinoma.
  • All 3 lesions were characterized microscopically by the presence of the so-called capillary lobule, a formation generally regarded as a sign of benignancy but that in this setting proved to be a forerunner or indicator of angiosarcoma (malignant hemangioendothelioma).
  • Therefore, the detection of capillary lobules in irradiated skin ought to be regarded with great suspicion, and other morphologic signs suggestive of angiosarcoma should be sought in the specimen.
  • [MeSH-major] Hemangiosarcoma / pathology. Neoplasms, Radiation-Induced / pathology. Neoplasms, Second Primary / pathology. Skin Neoplasms / pathology

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  • [CommentIn] Am J Dermatopathol. 2006 Aug;28(4):376 [16871048.001]
  • (PMID = 16121049.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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82. Gudewer E, Hölzle E, Li L: Widespread cutaneous angiosarcoma of the scalp: diagnosis and soft tissue reconstruction with a combined double-muscle-free flap and split-thickness-skin graft. Oral Maxillofac Surg; 2009 Jun;13(2):95-8
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  • [Title] Widespread cutaneous angiosarcoma of the scalp: diagnosis and soft tissue reconstruction with a combined double-muscle-free flap and split-thickness-skin graft.
  • BACKGROUND: Cutaneous angiosarcoma is a rare vascular tumor, which is usually located in the head and neck region.
  • CASE REPORT: After three punch biopsies, a 67-year-old patient, who had been healthy so far, was diagnosed with a cutaneous multilocated angiosarcoma of the scalp.
  • This flap was covered with split-thickness-skin in a second step.
  • [MeSH-major] Head and Neck Neoplasms / surgery. Hemangiosarcoma / surgery. Muscle, Skeletal / transplantation. Reconstructive Surgical Procedures / methods. Scalp / surgery. Skin Neoplasms / surgery. Skin Transplantation / methods. Surgical Flaps
  • [MeSH-minor] Aged. Biopsy, Needle / methods. Humans. Male. Microsurgery / methods. Neoplasm Staging. Radiotherapy, Adjuvant. Tomography, X-Ray Computed

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  • (PMID = 19301046.001).
  • [ISSN] 1865-1550
  • [Journal-full-title] Oral and maxillofacial surgery
  • [ISO-abbreviation] Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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83. Furusawa T, Matsumoto I, Oda M, Yachi T, Miyazu K, Watanabe G, Zen Y, Minato H, Shibata Y, Koda W: [Intractable pneumothorax secondary to pulmonary metastasis of angiosarcoma]. Kyobu Geka; 2008 Aug;61(9):779-83
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  • [Title] [Intractable pneumothorax secondary to pulmonary metastasis of angiosarcoma].
  • He had a previous history of angiosarcoma of the scalp, and had received local resection and chemoradiotherapy.
  • Although surgical resection for pneumothorax secondary to metastatic lung cancer is usually efficient, it is very hard to manage the pneumothorax of metastatic angiosarcoma.
  • [MeSH-major] Hemangiosarcoma / pathology. Lung Neoplasms / complications. Lung Neoplasms / secondary. Pneumothorax / etiology. Scalp. Skin Neoplasms / pathology

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  • (PMID = 18697460.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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84. Wiwatwongwana D, White VA, Dolman PJ: Two cases of periocular cutaneous angiosarcoma. Ophthal Plast Reconstr Surg; 2010 Sep-Oct;26(5):365-6
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  • [Title] Two cases of periocular cutaneous angiosarcoma.
  • Angiosarcoma is a rare malignancy with only 8 previous reports of eyelid involvement.
  • Although wide surgical margins were obtained and adjuvant radiotherapy and chemotherapy was undertaken, one patient had died from distant metastasis, while the second had distant cutaneous recurrences within 1 year.
  • [MeSH-major] Eyelid Neoplasms / pathology. Hemangiosarcoma / pathology. Hemangiosarcoma / secondary. Lung Neoplasms / secondary. Neoplasm Recurrence, Local / diagnosis. Skin Neoplasms / pathology

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  • [CommentIn] Ophthal Plast Reconstr Surg. 2012 Sep-Oct;28(5):386-7; author reply 387 [22965021.001]
  • (PMID = 20856078.001).
  • [ISSN] 1537-2677
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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85. Chen SY, Huang CZ, Qian Y, Wu Y, Tu YT: [Clinicopathologic study of 8 cases of poorly differentiated cutaneous angiosarcoma of scalp]. Zhonghua Bing Li Xue Za Zhi; 2008 May;37(5):313-5
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  • [Title] [Clinicopathologic study of 8 cases of poorly differentiated cutaneous angiosarcoma of scalp].
  • OBJECTIVE: To study the clinical and pathologic characteristics of poorly differentiated cutaneous angiosarcoma of scalp.
  • METHODS: Eight cases of poorly differentiated cutaneous angiosarcoma of scalp were enrolled into this study.
  • Conclusions Angiosarcoma needs to be excluded by histologic examination whenever bruise-like and erythematous lesions occurring on scalp skin of elderly patients.
  • [MeSH-major] Antigens, CD31 / immunology. Antigens, CD34 / immunology. Hemangiosarcoma / immunology. Scalp / pathology. Skin Neoplasms / immunology. Vimentin / analysis

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  • (PMID = 18956649.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Antigens, CD34; 0 / Biomarkers, Tumor; 0 / Cell Adhesion Molecules; 0 / Vimentin
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86. Marthya A, Patinharayil G, Puthezeth K, Sreedharan S, Kumar A, Kumaran CM: Multicentric epithelioid angiosarcoma of the spine: a case report of a rare bone tumor. Spine J; 2007 Nov-Dec;7(6):716-9
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  • [Title] Multicentric epithelioid angiosarcoma of the spine: a case report of a rare bone tumor.
  • BACKGROUND CONTEXT: Epithelioid angiosarcoma (EA) is a high-grade sarcoma of vascular origin.
  • EA is a rare variant of angiosarcoma.
  • EA has been reported in sites like skin thyroid, adrenal gland, soft tissue, and rarely in bone.
  • The tumor was composed of nests and cords of malignant cells with epithelioid morphology with areas of vascular differentiation, necrosis, and hemorrhage.
  • The authors point out the need for immunohistochemical evaluation after careful histological analysis for vascular differentiation for an accurate diagnosis of vascular bone tumors with epithelioid features so that an erroneous diagnosis of metastatic carcinoma can be avoided.
  • EA is marked by the presence of large polygonal epithelioid malignant cells with marked cellular atypia and pleomorphism.
  • The arrangement of the cells may mimic epithelial neoplasm.
  • Careful histologic and immunohistochemical analysis will clinch the diagnosis.
  • Even though rare, we stress the importance to be aware of the existence of this tumor, which is essential for correct diagnosis.
  • [MeSH-major] Bone Neoplasms / pathology. Epithelioid Cells / pathology. Hemangiosarcoma / pathology. Magnetic Resonance Imaging. Thoracic Vertebrae / pathology

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  • (PMID = 17998131.001).
  • [ISSN] 1529-9430
  • [Journal-full-title] The spine journal : official journal of the North American Spine Society
  • [ISO-abbreviation] Spine J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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87. Rozen WM, Mann GB: Angiosarcoma arising in an unirradiated breast with subsequent pituitary metastasis. Clin Breast Cancer; 2007 Oct;7(10):811-3
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  • [Title] Angiosarcoma arising in an unirradiated breast with subsequent pituitary metastasis.
  • Angiosarcoma of the breast is a rare condition with known risk factors.
  • The Stewart-Treves syndrome describes angiosarcoma of the arm or breast in the setting of adjuvant radiation therapy (RT) after breast conservation surgery.
  • Angiosarcoma of the breast, in the absence of RT, is rarer still.
  • We present a unique case of angiosarcoma of the breast, diagnosed 6 years after conservative surgery for carcinoma of the breast when no adjuvant RT was given.
  • Chronic postoperative lymphoedema in the breast delayed the investigation of skin changes, with an eventual diagnosis of angiosarcoma.
  • An isolated pituitary metastasis 9 months from the diagnosis, the first such reported case, adds to the complexity of the case.
  • The diagnosis and management of angiosarcoma of the breast is discussed.
  • Angiosarcoma is a rare occurrence after breast conservative surgery.
  • Postoperative lymphoedema can impede early diagnosis.
  • [MeSH-major] Breast Neoplasms / pathology. Hemangiosarcoma / secondary. Neoplasms, Second Primary / pathology. Pituitary Neoplasms / secondary

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  • (PMID = 18021485.001).
  • [ISSN] 1526-8209
  • [Journal-full-title] Clinical breast cancer
  • [ISO-abbreviation] Clin. Breast Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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88. Sanders LM, Groves AC, Schaefer S: Cutaneous angiosarcoma of the breast on MRI. AJR Am J Roentgenol; 2006 Aug;187(2):W143-6
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  • [Title] Cutaneous angiosarcoma of the breast on MRI.
  • [MeSH-major] Breast Neoplasms / diagnosis. Hemangiosarcoma / diagnosis. Magnetic Resonance Imaging. Skin Neoplasms / diagnosis

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  • (PMID = 16861502.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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89. Rodríguez-Bujaldón A, Vázquez-Bayo MC, Galán-Gutiérrez M, Jiménez-Puya R, Vélez García-Nieto A, Moreno-Giménez JC, Vidal-Jiménez A, Barroso-Casamitjana E: [Angiosarcoma in chronic lymphedema]. Actas Dermosifiliogr; 2006 Oct;97(8):525-8
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  • [Title] [Angiosarcoma in chronic lymphedema].
  • [Transliterated title] Angiosarcoma sobre linfedema crónico.
  • Angiosarcoma that develops on a limb with chronic lymphedema is called Stewart-Treves syndrome.
  • The first corresponds to a typical syndrome of Stewart-Treves in an 83-year-old woman who was diagnosed of angiosarcoma in a chronic lymphedema territory secondary to mastectomy and radiotherapy due to breast cancer.
  • The second case is much rarer, since it is a case of diffuse angiosarcoma of the leg in a 42-year-old man with a history of lymphedema.
  • [MeSH-major] Hemangiosarcoma / etiology. Lymphedema / complications
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antibiotics, Antineoplastic / administration & dosage. Antibiotics, Antineoplastic / therapeutic use. Antineoplastic Agents, Alkylating / administration & dosage. Antineoplastic Agents, Alkylating / therapeutic use. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Arm. Doxorubicin / administration & dosage. Doxorubicin / therapeutic use. Female. Humans. Ifosfamide / administration & dosage. Ifosfamide / therapeutic use. Immunohistochemistry. Leg. Male. Skin / pathology. Skin Neoplasms / diagnosis. Skin Neoplasms / drug therapy. Skin Neoplasms / etiology. Skin Neoplasms / pathology. Skin Neoplasms / radiotherapy. Treatment Outcome

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  • (PMID = 17067532.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Antineoplastic Agents, Alkylating; 80168379AG / Doxorubicin; UM20QQM95Y / Ifosfamide
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90. Gambassi G, Semeraro R, Suma V, Sebastio A, Incalzi RA: Aggressive behavior of classical Kaposi's sarcoma and coexistence with angiosarcoma. J Gerontol A Biol Sci Med Sci; 2005 Apr;60(4):520-3
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  • [Title] Aggressive behavior of classical Kaposi's sarcoma and coexistence with angiosarcoma.
  • Histology allowed a diagnosis of the classical form of Kaposi's sarcoma; the serology test result for HIV was negative, whereas the associated human herpes virus type 8 was detected by polymerase chain reaction on the skin sample.
  • Over the subsequent 6 months, skin lesions become vegetative and partially necrotic, and extended to the hands and eyelids.
  • Chemotherapy with vinblastine appeared to stabilize the cutaneous disease, but the patient developed a massive gastrointestinal hemorrhage secondary to dissemination to the stomach.
  • Twelve months after the onset of the disease, vegetative and easily bleeding lesions progressively occluded the mouth of the patient: histological features were consistent with a low-grade angiosarcoma distinct from that of Kaposi's sarcoma.
  • This case illustrates that, even in its classical form, Kaposi's sarcoma may be a malignant, rapidly progressing tumor.
  • LEARNING POINTS: a) The extent and rate of spread of initial skin lesions should be considered to be early signs of aggressive dissemination, even in the absence of other variables (i.e., histological pattern, human herpes virus type 8 positive mononuclear cells) associated with progression of the disease.
  • c) When classical Kaposi's sarcoma displays aggressive behavior a second, primary malignant tumor arising from the vascular tissue should be investigated.
  • TAKE-HOME MESSAGE: Even in its classical form, Kaposi's sarcoma may be a malignant, rapidly progressing tumor with visceral involvement; also, a second malignancy may occur in nearly one patient of four.
  • Because localized skin lesions can regress completely with radiotherapy, watchful waiting is probably inappropriate in most cases.
  • [MeSH-major] Foot Diseases / pathology. Hemangiosarcoma / pathology. Neoplasms, Multiple Primary / pathology. Palatal Neoplasms / pathology. Sarcoma, Kaposi / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Fatal Outcome. Follow-Up Studies. Humans. Male. Neoplasm Invasiveness

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  • (PMID = 15933395.001).
  • [ISSN] 1079-5006
  • [Journal-full-title] The journals of gerontology. Series A, Biological sciences and medical sciences
  • [ISO-abbreviation] J. Gerontol. A Biol. Sci. Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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91. Gengler C, Coindre JM, Leroux A, Trassard M, Ranchère-Vince D, Valo I, Michels JJ, Guillou L: Vascular proliferations of the skin after radiation therapy for breast cancer: clinicopathologic analysis of a series in favor of a benign process: a study from the French Sarcoma Group. Cancer; 2007 Apr 15;109(8):1584-98
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  • [Title] Vascular proliferations of the skin after radiation therapy for breast cancer: clinicopathologic analysis of a series in favor of a benign process: a study from the French Sarcoma Group.
  • BACKGROUND: Cutaneous vascular proliferations that occur in the field of prior radiotherapy include angiosarcoma and small, cutaneous lesions with a pseudosarcomatous pattern that previously were reported as atypical vascular lesions or benign lymphangiomatous papules.
  • Data from all patients were retrieved from the files of the French Sarcoma Group.
  • Follow-up information was available for 31 patients (median follow-up, 48 months): Five women developed new cutaneous lesions, and 1 woman had spontaneous regression of her lesions.
  • None of the patients developed cutaneous angiosarcoma.
  • CONCLUSIONS: Although vascular proliferations in irradiated skin may mimic angiosarcoma morphologically, the large majority of these lesions showed a benign clinical outcome.
  • [MeSH-major] Breast Neoplasms / radiotherapy. Lymphangioma / pathology. Neoplasms, Radiation-Induced / pathology. Radiotherapy / adverse effects. Skin / blood supply. Skin / radiation effects. Skin Neoplasms / etiology. Skin Neoplasms / pathology


92. Pan Z, Albertson D, Bhuller A, Wang B, Shehan JM, Sarma DP: Angiosarcoma of the scalp mimicking a sebaceous cyst. Dermatol Online J; 2008;14(6):13
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  • [Title] Angiosarcoma of the scalp mimicking a sebaceous cyst.
  • Because there was no resolution, a biopsy was performed that revealed a high grade angiosarcoma.
  • Cutaneous angiosarcoma is an extremely aggressive tumor.
  • Therefore early diagnosis and management is crucial in providing better patient care.
  • [MeSH-major] Epidermal Cyst / pathology. Hemangiosarcoma / pathology. Scalp. Scalp Dermatoses / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Drainage. Ear. Fatal Outcome. Female. Humans. Immunohistochemistry. Infection / diagnosis. Middle Aged


93. Perrotto J, Glick B: Lower extremity malignancies masquerading as ulcers. Ostomy Wound Manage; 2006 Oct;52(10):46-52
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  • Cutaneous malignancies that may masquerade as ulcers include nodulo-ulcerative basal cell carcinoma, squamous cell carcinoma, keratoacanthoma, nodular melanoma, tumor stage mycosis fungoides, lymphomatoid granulomatosis, lymphomatoid papulosis, angiosarcoma, and cutaneous metastases from internal malignancy.
  • [MeSH-major] Neoplasms / diagnosis. Skin Ulcer / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Humans

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  • (PMID = 17041254.001).
  • [ISSN] 0889-5899
  • [Journal-full-title] Ostomy/wound management
  • [ISO-abbreviation] Ostomy Wound Manage
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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94. Donghi D, Kerl K, Dummer R, Schoenewolf N, Cozzio A: Cutaneous angiosarcoma: own experience over 13 years. Clinical features, disease course and immunohistochemical profile. J Eur Acad Dermatol Venereol; 2010 Oct;24(10):1230-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cutaneous angiosarcoma: own experience over 13 years. Clinical features, disease course and immunohistochemical profile.
  • BACKGROUND: Cutaneous angiosarcoma (AS) is a rare malignant tumour of endothelial origin with very poor prognosis, frequent recurrences and high metastatic potential.
  • RESULTS AND CONCLUSIONS: Cutaneous AS was clinically diagnosed in 4 of 9 patients, while systemic lupus erythematosus was the most common misdiagnosis.
  • [MeSH-major] Hemangiosarcoma / diagnosis. Hemangiosarcoma / pathology. Skin Neoplasms / diagnosis. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Antibodies, Monoclonal / metabolism. Antibodies, Monoclonal, Murine-Derived. Biomarkers, Tumor / metabolism. Combined Modality Therapy. Diagnosis, Differential. Female. Humans. Ki-67 Antigen / metabolism. Lupus Erythematosus, Systemic / diagnosis. Male. Middle Aged. Prognosis. Retrospective Studies

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  • (PMID = 20236193.001).
  • [ISSN] 1468-3083
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / monoclonal antibody D2-40
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95. Nakamura Y, Nakamura Y, Hori E, Furuta J, Kawachi Y, Otsuka F: Complete long-term response of angiosarcoma of the scalp with cervical lymph node metastases treated with a combination of weekly and monthly docetaxel. Br J Dermatol; 2010 Dec;163(6):1357-8
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  • [Title] Complete long-term response of angiosarcoma of the scalp with cervical lymph node metastases treated with a combination of weekly and monthly docetaxel.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Head and Neck Neoplasms / drug therapy. Hemangiosarcoma / drug therapy. Scalp. Skin Neoplasms / drug therapy. Taxoids / therapeutic use

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  • (PMID = 20731655.001).
  • [ISSN] 1365-2133
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Taxoids; 15H5577CQD / docetaxel
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96. Ordoñez-Escalante KG, Mantilla-Morales A, Gallegos F: [Nasal cavity angiosarcoma: a case report and literature review]. Gac Med Mex; 2006 Mar-Apr;142(2):155-8
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  • [Title] [Nasal cavity angiosarcoma: a case report and literature review].
  • [Transliterated title] Angiosarcoma de cavidad nasal: informe de un caso y revisión de la literatura.
  • Angiosarcomas comprise 2% of all soft tissue tumors, 60% appear in skin and soft tissue, 50% in the head and neck and only 4% are present in the upper aerodigestive tract.
  • The histopathologic diagnosis was angiosarcoma.
  • Agiosarcomas of the upper aerodigestive tract have a better prognosis and long term survival free of disease than their soft tissue and skin counterparts.
  • [MeSH-major] Hemangiosarcoma / diagnosis. Nasal Cavity. Nose Neoplasms / diagnosis

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  • (PMID = 16711550.001).
  • [ISSN] 0016-3813
  • [Journal-full-title] Gaceta médica de México
  • [ISO-abbreviation] Gac Med Mex
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Mexico
  • [Number-of-references] 22
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97. Ryu DY, Hwang SY, Lee DW, Kim TO, Park DY, Kim GH, Heo J, Kang DH, Song GA, Cho M: [A case of primary angiosarcoma of small intestine presenting as recurrent gastrointestinal bleeding]. Korean J Gastroenterol; 2005 Nov;46(5):404-8
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  • [Title] [A case of primary angiosarcoma of small intestine presenting as recurrent gastrointestinal bleeding].
  • Angiosarcoma is a rare malignant tumor which occurs frequently in the skin and soft subcutis.
  • The diagnosis is often made at an advanced stage.
  • We report a case of primary angiosarcoma of the small intestine presenting as recurrent gastrointestinal bleeding.
  • The ileal mass was diagnosed as angiosarcoma on immunohistochemical stain.
  • He received 3 cycles of chemotherapy, but died 5 months after the diagnosis.
  • [MeSH-major] Gastrointestinal Hemorrhage / etiology. Hemangiosarcoma / diagnosis. Intestinal Neoplasms / diagnosis. Intestine, Small

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  • (PMID = 16301855.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Korea (South)
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98. Abraham JA, Hornicek FJ, Kaufman AM, Harmon DC, Springfield DS, Raskin KA, Mankin HJ, Kirsch DG, Rosenberg AE, Nielsen GP, Desphpande V, Suit HD, DeLaney TF, Yoon SS: Treatment and outcome of 82 patients with angiosarcoma. Ann Surg Oncol; 2007 Jun;14(6):1953-67
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Treatment and outcome of 82 patients with angiosarcoma.
  • METHODS: Patients with a diagnosis of angiosarcoma treated at our institution between 1980 and 2006 were analyzed for patient demographics, tumor characteristics, multimodality treatment, and outcomes.
  • Tumors were located throughout the body: 32 cutaneous, 22 deep soft tissues or organs, 10 radiation or lymphedema field, 8 bone, and 7 nonirradiated breast.
  • Median survival was just 7.3 months, and cutaneous tumors predicted a better prognosis compared with other sites.
  • [MeSH-major] Hemangiosarcoma / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Bone Neoplasms / pathology. Bone Neoplasms / surgery. Breast Neoplasms / pathology. Breast Neoplasms / surgery. Chemotherapy, Adjuvant. Disease-Free Survival. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoadjuvant Therapy. Neoplasm Staging. Neoplasms, Radiation-Induced / pathology. Neoplasms, Radiation-Induced / surgery. Palliative Care. Radiotherapy, Adjuvant. Retrospective Studies. Skin Neoplasms / pathology. Skin Neoplasms / surgery. Soft Tissue Neoplasms / pathology. Soft Tissue Neoplasms / surgery. Survival Rate. Treatment Outcome

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  • (PMID = 17356953.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / 5K12CA87723-03
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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99. Imafuku S, Hosokawa C, Moroi Y, Furue M: Kasabach-Merritt syndrome associated with angiosarcoma of the scalp successfully treated with chemoradiotherapy. Acta Derm Venereol; 2008;88(2):193-4
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  • [Title] Kasabach-Merritt syndrome associated with angiosarcoma of the scalp successfully treated with chemoradiotherapy.
  • [MeSH-major] Disseminated Intravascular Coagulation / complications. Head and Neck Neoplasms / complications. Hemangiosarcoma / complications. Scalp. Skin Neoplasms / complications

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  • (PMID = 18311463.001).
  • [ISSN] 0001-5555
  • [Journal-full-title] Acta dermato-venereologica
  • [ISO-abbreviation] Acta Derm. Venereol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Sweden
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100. Al Ali J, Ko HH, Owen D, Steinbrecher UP: Epithelioid angiosarcoma of the small bowel. Gastrointest Endosc; 2006 Dec;64(6):1018-21
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  • [Title] Epithelioid angiosarcoma of the small bowel.
  • BACKGROUND: Angiosarcoma is a rare soft-tissue neoplasm that occurs most often in the skin and the subcutaneous tissues but very rarely in the GI tract.
  • DESIGN: We report a case of multifocal epithelioid angiosarcoma involving skin and bowel and review the 18 previously reported cases of epithelioid intestinal angiosarcoma.
  • Two small blue-black nodules were present on the skin.
  • Biopsy specimens of skin and duodenal nodules showed epithelioid angiosarcoma.
  • RESULTS: The intestinal nodules were treated with argon plasma coagulation, but the patient died 6 weeks after diagnosis.
  • CONCLUSIONS: The survival rate of intestinal angiosarcoma is poor, and most cases progress rapidly, with a 2-month median survival after diagnosis.
  • Further studies are needed to establish the role of adjuvant radiation or chemotherapy in the treatment of angiosarcoma.
  • [MeSH-major] Hemangiosarcoma / pathology. Intestinal Neoplasms / pathology. Intestine, Small
  • [MeSH-minor] Aged, 80 and over. Biopsy. Diagnosis, Differential. Endoscopy, Gastrointestinal. Fatal Outcome. Humans. Male. Tomography, X-Ray Computed

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  • (PMID = 17140922.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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