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Items 1 to 100 of about 222
1. Al Ali J, Ko HH, Owen D, Steinbrecher UP: Epithelioid angiosarcoma of the small bowel. Gastrointest Endosc; 2006 Dec;64(6):1018-21
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  • [Title] Epithelioid angiosarcoma of the small bowel.
  • BACKGROUND: Angiosarcoma is a rare soft-tissue neoplasm that occurs most often in the skin and the subcutaneous tissues but very rarely in the GI tract.
  • DESIGN: We report a case of multifocal epithelioid angiosarcoma involving skin and bowel and review the 18 previously reported cases of epithelioid intestinal angiosarcoma.
  • Two small blue-black nodules were present on the skin.
  • Biopsy specimens of skin and duodenal nodules showed epithelioid angiosarcoma.
  • RESULTS: The intestinal nodules were treated with argon plasma coagulation, but the patient died 6 weeks after diagnosis.
  • CONCLUSIONS: The survival rate of intestinal angiosarcoma is poor, and most cases progress rapidly, with a 2-month median survival after diagnosis.
  • Further studies are needed to establish the role of adjuvant radiation or chemotherapy in the treatment of angiosarcoma.
  • [MeSH-major] Hemangiosarcoma / pathology. Intestinal Neoplasms / pathology. Intestine, Small
  • [MeSH-minor] Aged, 80 and over. Biopsy. Diagnosis, Differential. Endoscopy, Gastrointestinal. Fatal Outcome. Humans. Male. Tomography, X-Ray Computed

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  • (PMID = 17140922.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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2. Penel N, Bui BN, Bay JO, Cupissol D, Ray-Coquard I, Piperno-Neumann S, Kerbrat P, Fournier C, Taieb S, Jimenez M, Isambert N, Peyrade F, Chevreau C, Bompas E, Brain EG, Blay JY: Phase II trial of weekly paclitaxel for unresectable angiosarcoma: the ANGIOTAX Study. J Clin Oncol; 2008 Nov 10;26(32):5269-74
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  • [Title] Phase II trial of weekly paclitaxel for unresectable angiosarcoma: the ANGIOTAX Study.
  • PURPOSE: The objective of this phase II trial was to assess the efficacy and toxicity of weekly paclitaxel for patients with metastatic or unresectable angiosarcoma.
  • Three patients with locally advanced breast angiosarcoma presented partial response, which enabled a secondary curative-intent surgery with complete histologic response in two cases.
  • [MeSH-major] Antineoplastic Agents, Phytogenic / administration & dosage. Breast Neoplasms / drug therapy. Head and Neck Neoplasms / drug therapy. Hemangiosarcoma / drug therapy. Paclitaxel / administration & dosage. Scalp. Skin Neoplasms / drug therapy. Soft Tissue Neoplasms / drug therapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Disease-Free Survival. Drug Administration Schedule. Female. France / epidemiology. Humans. Infusions, Intravenous. Kaplan-Meier Estimate. Male. Middle Aged. Neoplasm Metastasis. Time Factors. Treatment Outcome

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  • (PMID = 18809609.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; P88XT4IS4D / Paclitaxel
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3. Kajo K, Lúcan J, Macháleková K, Beratsová Z: [Cutaneous angiosarcoma following conservative surgery and radiotherapy for breast carcinoma. A case report]. Cesk Patol; 2007 Apr;43(2):59-63
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  • [Title] [Cutaneous angiosarcoma following conservative surgery and radiotherapy for breast carcinoma. A case report].
  • Breast angiosarcomas (AS) are very rare neoplasms, which can be divided into primary (or sporadic), and secondary AS, the latter arising either on the base of lymphoedema after mastectomy (so called AS with Stewart-Treves syndrome- ASSTS), or skin AS after breast conservation surgery with subsequent radiotherapy for breast cancer (KPRAS).
  • The authors present a case of a 55-year-old female patient with a 17mm tumour in nipple region, developing 8 years after primary diagnosis of tubulolobular carcinoma of the breast which was treated by breast conservation surgery and radiotherapy.
  • [MeSH-major] Breast Neoplasms / radiotherapy. Breast Neoplasms / surgery. Hemangiosarcoma / etiology. Neoplasms, Second Primary / pathology. Skin Neoplasms / etiology

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  • (PMID = 17623978.001).
  • [ISSN] 1210-7875
  • [Journal-full-title] Československá patologie
  • [ISO-abbreviation] Cesk Patol
  • [Language] slo
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Czech Republic
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4. Dagrégorio G, Levillain P, Guillet G: [Angiosarcoma of the scalp: an unusual clinical presentation]. Ann Dermatol Venereol; 2005 Dec;132(12 Pt 1):1038-9
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  • [Title] [Angiosarcoma of the scalp: an unusual clinical presentation].
  • [Transliterated title] Angiosarcome du cuir chevelu: une présentation clinique inhabituelle.
  • [MeSH-major] Hemangiosarcoma / pathology. Scalp / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Male

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  • (PMID = 16446659.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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5. Chin WW, Heng PW, Thong PS, Bhuvaneswari R, Hirt W, Kuenzel S, Soo KC, Olivo M: Improved formulation of photosensitizer chlorin e6 polyvinylpyrrolidone for fluorescence diagnostic imaging and photodynamic therapy of human cancer. Eur J Pharm Biopharm; 2008 Aug;69(3):1083-93
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  • An improved formulation of the photosensitizer chlorin e6 (Ce6) in combination with the hydrophilic polymer polyvinylpyrrolidone (PVP) was investigated for its potential clinical applications in fluorescence diagnosis and photodynamic therapy (PDT) of cancer.
  • In patients, preferential accumulation of Ce6-PVP was observed in angiosarcoma lesions compared to normal skin following intravenous administration.
  • [MeSH-minor] Animals. Cell Line, Tumor. Cell Survival / drug effects. Chemistry, Pharmaceutical. Hemangiosarcoma / pathology. Hemangiosarcoma / therapy. Humans. Image Processing, Computer-Assisted. Male. Mice. Mice, Inbred BALB C. Microscopy, Fluorescence. Middle Aged. Nonlinear Dynamics. Povidone / chemistry. ROC Curve. Regression Analysis. Spectrometry, Fluorescence. Tissue Distribution. Xenograft Model Antitumor Assays

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  • (PMID = 18396019.001).
  • [ISSN] 0939-6411
  • [Journal-full-title] European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V
  • [ISO-abbreviation] Eur J Pharm Biopharm
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Photosensitizing Agents; 0 / Porphyrins; 19660-77-6 / chlorin e6; 9003-39-8 / Povidone
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6. Crosby MA, Chike-Obi CJ, Baumann DP, Sacks JM, Villa MT, Garvey PB, Selber JC, Feig BW: Reconstructive outcomes in patients with sarcoma of the breast. Plast Reconstr Surg; 2010 Dec;126(6):1805-14
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  • [Title] Reconstructive outcomes in patients with sarcoma of the breast.
  • The purpose of this study was to examine reconstruction techniques and outcomes in a cohort of patients with breast sarcoma to elucidate the optimal type and timing of reconstruction.
  • RESULTS: Twenty-three breast sarcoma patients underwent 24 reconstructions.
  • The mean age at diagnosis was 42 years (range, 17 to 78 years).
  • The most common histologic finding was angiosarcoma; six of the 11 angiosarcomas developed following irradiation for either breast carcinoma or lymphoma.
  • Surgical complications included implant displacement, tissue expander displacement, total flap loss, seroma, implant exposure, and partial skin graft loss.
  • Most sarcoma patients receive radiotherapy; to minimize complications, we recommend delayed autologous reconstruction after completion of radiotherapy.
  • [MeSH-major] Breast Implantation / methods. Breast Neoplasms / surgery. Mammaplasty / methods. Postoperative Complications / etiology. Sarcoma / surgery. Surgical Flaps / blood supply
  • [MeSH-minor] Adolescent. Adult. Aged. Combined Modality Therapy. Disease-Free Survival. Female. Hemangiosarcoma / mortality. Hemangiosarcoma / surgery. Humans. Middle Aged. Neoplasm Recurrence, Local / mortality. Neoplasm Recurrence, Local / surgery. Neoplasms, Radiation-Induced / mortality. Neoplasms, Radiation-Induced / surgery. Neoplasms, Second Primary / mortality. Neoplasms, Second Primary / surgery. Reoperation. Retrospective Studies. Treatment Outcome. Young Adult


7. Spillane EL, Xia Y, Turiansky GW: Atypical cutaneous presentation of Waldenström macroglobulinemia: an extensive erythematous patch mimicking an angiosarcoma. Cutis; 2008 Jan;81(1):67-8
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  • [Title] Atypical cutaneous presentation of Waldenström macroglobulinemia: an extensive erythematous patch mimicking an angiosarcoma.
  • Waldenström macroglobulinemia (WM) is an immunoglobulin M-producing lymphoproliferative disorder in elderly individuals.
  • Cutaneous manifestations of WM are rare and typically consist of plaques or nodules.
  • We describe a case of a man with WM who presented with an extensive erythematous patch on the scalp that clinically mimicked an angiosarcoma.
  • [MeSH-major] Hemangiosarcoma / diagnosis. Skin / pathology. Skin Neoplasms / diagnosis. Waldenstrom Macroglobulinemia / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged. Scalp / pathology

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  • (PMID = 18306851.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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8. Salomäki HH, Sainio AO, Söderström M, Pakkanen S, Laine J, Järveläinen HT: Differential expression of decorin by human malignant and benign vascular tumors. J Histochem Cytochem; 2008 Jul;56(7):639-46
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  • [Title] Differential expression of decorin by human malignant and benign vascular tumors.
  • Given that angiogenesis is a sine qua non for tumor growth and progression, we attempted to examine whether human malignant vascular tumors differ from human benign vascular tumors in terms of their decorin expression and synthesis.
  • CD31 immunostaining demonstrated that the human malignant vascular tumors Kaposi's sarcoma and angiosarcoma were filled with capillary-like structures, whereas in benign cavernous and capillary hemangiomas, blood vessels were not as abundantly present.
  • By utilizing in situ hybridization and immunocytochemical assays for decorin, we showed that there was no detectable decorin mRNA expression or immunoreactivity within the tumor mass in the Kaposi's sarcoma or angiosarcoma group.
  • Instead, decorin was expressed in the connective tissue stroma lining the sarcoma tissue.
  • Decorin certainly provides a usable biomarker for distinguishing between benign and malignant vascular tumors in patients.
  • [MeSH-major] Extracellular Matrix Proteins / biosynthesis. Hemangioma, Capillary / metabolism. Hemangioma, Cavernous / metabolism. Hemangiosarcoma / metabolism. Proteoglycans / biosynthesis. Sarcoma, Kaposi / metabolism. Skin Neoplasms / metabolism

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  • (PMID = 18413650.001).
  • [ISSN] 0022-1554
  • [Journal-full-title] The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
  • [ISO-abbreviation] J. Histochem. Cytochem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Collagen Type I; 0 / DCN protein, human; 0 / Decorin; 0 / Extracellular Matrix Proteins; 0 / Proteoglycans; 0 / RNA, Messenger; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
  • [Other-IDs] NLM/ PMC2430166
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9. Montgomery E, Epstein JI: Anastomosing hemangioma of the genitourinary tract: a lesion mimicking angiosarcoma. Am J Surg Pathol; 2009 Sep;33(9):1364-9
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  • [Title] Anastomosing hemangioma of the genitourinary tract: a lesion mimicking angiosarcoma.
  • BACKGROUND: We describe 6 cases of a poorly recognized vascular neoplasm that can simulate angiosarcoma.
  • Two (33%) tumors featured prominent extra-medullary hematopoiesis and 2 tumors (33%) had striking hyaline globules reminiscent of those seen in Kaposi's sarcoma.
  • In all but one submitted consultation, the possibility of angiosarcoma had been raised based on the anastomosing vascular pattern.
  • CONCLUSIONS: Anastomosing hemangioma of the genitourinary tract is a rare neoplasm displaying some overlapping features of both sinusoidal hemangioma and hobnail hemangioma of soft tissue and skin.
  • However, in our opinion, it is a unique neoplasm with a proclivity for the kidney.
  • Its anastomosing appearance can lead to concern for angiosarcoma but, despite small numbers and limited follow-up in our series, evidence to date supports that the lesion is benign.
  • [MeSH-major] Hemangioma / pathology. Hemangiosarcoma / pathology. Urogenital Neoplasms / pathology
  • [MeSH-minor] Aged. Antigens, CD31 / analysis. Antigens, CD34 / analysis. Biomarkers, Tumor / analysis. Diagnosis, Differential. Factor VIII / analysis. Female. Humans. Kidney Neoplasms / chemistry. Kidney Neoplasms / pathology. Male. Middle Aged. Prospective Studies. Testicular Neoplasms / chemistry. Testicular Neoplasms / pathology. Treatment Outcome

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  • (PMID = 19606014.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Antigens, CD34; 0 / Biomarkers, Tumor; 0 / F8 protein, human; 9001-27-8 / Factor VIII
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10. Cronin H, Mowad C, Ferringer T: Large nodular plaque on leg in the setting of chronic lymphedema--quiz case. Angiosarcoma in the setting of familial lymphedema. Arch Dermatol; 2010 Mar;146(3):337-42
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  • [Title] Large nodular plaque on leg in the setting of chronic lymphedema--quiz case. Angiosarcoma in the setting of familial lymphedema.
  • [MeSH-major] Hemangiosarcoma / diagnosis. Lymphedema / complications. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adult. Biopsy. Chronic Disease. Diagnosis, Differential. Humans. Leg. Male

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  • (PMID = 20231513.001).
  • [ISSN] 1538-3652
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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11. Perry B, Banyard J, McLaughlin ER, Watnick R, Sohn A, Brindley DN, Obata T, Cantley LC, Cohen C, Arbiser JL: AKT1 overexpression in endothelial cells leads to the development of cutaneous vascular malformations in vivo. Arch Dermatol; 2007 Apr;143(4):504-6
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  • [Title] AKT1 overexpression in endothelial cells leads to the development of cutaneous vascular malformations in vivo.
  • The histologic features of these vascular malformations is distinct from ras-transformed MS1 cells (angiosarcoma) and suggest that differing signal abnormalities give rise to human vascular malformations vs malignant vascular tumors.

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  • (PMID = 17438183.001).
  • [ISSN] 0003-987X
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] ENG
  • [Grant] United States / NIGMS NIH HHS / GM / R01 GM041890; United States / NIAMS NIH HHS / AR / P30 AR42687; United States / NIAMS NIH HHS / AR / R01 AR47901
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.11.1 / AKT1 protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt
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12. Yoon TY, Kim HJ, Kim JW, Kim MK, Lee JY: Bowen's disease concealed by purpura. J Dermatol; 2007 Jan;34(1):65-7
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  • However, angiosarcoma has not usually been mentioned in the differential diagnosis of BD before.
  • Herein, we describe two cases of BD presenting as purpura on the scalp of the elderly with an initial clinical suspicion of angiosarcoma.
  • [MeSH-major] Bowen's Disease / complications. Purpura / complications. Scalp. Skin Neoplasms / complications
  • [MeSH-minor] Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans

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  • (PMID = 17204105.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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13. Emberger M, Laimer M, Steiner H, Zelger B: Retiform hemangioendothelioma: presentation of a case expressing D2-40. J Cutan Pathol; 2009 Sep;36(9):987-90
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  • Retiform hemangioendothelioma (RH) is a low-grade angiosarcoma with low metastatic risk, usually occurring as a single lesion on the trunk or extremity in middle-aged adults.
  • [MeSH-major] Antibodies, Monoclonal / metabolism. Hemangioendothelioma / pathology. Skin Neoplasms / pathology

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  • (PMID = 19674202.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Biomarkers, Tumor; 0 / monoclonal antibody D2-40
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14. Costache M, Ene AM, Simionescu O, Sajin M: Histopathological diagnosis of cutaneous vascular sarcomas. Rom J Morphol Embryol; 2010;51(1):105-9
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  • [Title] Histopathological diagnosis of cutaneous vascular sarcomas.
  • Cutaneous sarcomas represent a heterogeneous group of mesenchymal lesions.
  • This study investigates the histopathological and immunohistochemical features in different cases of angiosarcoma and Kaposi's sarcoma (cutaneous vascular sarcomas), which are representative for medical practice.
  • The clinical-histopathological-immunohistochemical correlations render possible the differential diagnosis and a proper treatment can be applied to obtain a favorable prognosis.
  • [MeSH-major] Hemangiosarcoma / diagnosis. Hemangiosarcoma / pathology. Skin Neoplasms / diagnosis. Skin Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Prognosis. Sarcoma, Kaposi / diagnosis. Sarcoma, Kaposi / pathology

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  • (PMID = 20191128.001).
  • [ISSN] 1220-0522
  • [Journal-full-title] Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
  • [ISO-abbreviation] Rom J Morphol Embryol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Romania
  • [Number-of-references] 18
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15. Scheinfeld N: Review of scalp alopecia due to a clinically unapparent or minimally apparent neoplasm (SACUMAN). Acta Derm Venereol; 2006;86(5):387-92
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  • [Title] Review of scalp alopecia due to a clinically unapparent or minimally apparent neoplasm (SACUMAN).
  • Neoplastic cells, both malignant and benign, local occurring and metastatic, can cause alopecia of the scalp.
  • However, the infiltration of neoplastic cells is sometimes not florid; a condition known as "scalp alopecia due to a clinically unapparent or minimally apparent neoplasm" (SACUMAN).
  • The most common neoplasm in which an uncomplicated, minimally or unapparent scalp alopecia occurs and no infiltrate of cancer is suspected is metastatic breast carcinoma.
  • Other causes include squamous and basal cell carcinomas, angiosarcoma, gastric carcinoma, placental site tromphoblastic tumor, and mycosis fungoides.
  • Dermatologists must be aware that in rare cases a bland scalp alopecia can represent a new or recurring, local or metastatic neoplasm.
  • [MeSH-major] Alopecia / etiology. Skin Neoplasms / pathology
  • [MeSH-minor] Breast Neoplasms / pathology. Carcinoma, Basal Cell / pathology. Cicatrix / pathology. Hemangiosarcoma / pathology. Humans. Keloid / complications. Keloid / pathology. Lymphoma / pathology. Scalp / pathology

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  • (PMID = 16983449.001).
  • [ISSN] 0001-5555
  • [Journal-full-title] Acta dermato-venereologica
  • [ISO-abbreviation] Acta Derm. Venereol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Norway
  • [Number-of-references] 56
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16. Venkataraman G, Hammadeh R: Report of an angiosarcoma mimic: cutaneous aneurysmal fibrous histiocytoma. APMIS; 2006 Oct;114(10):744-8
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  • [Title] Report of an angiosarcoma mimic: cutaneous aneurysmal fibrous histiocytoma.
  • It looks strikingly different from the usual cutaneous lesions encountered in clinical dermatology practice.
  • A single report of a cutaneous aneurysmal fibrous histiocytoma in the skin of the back of a 60-year-old male is described with emphasis on the immunostaining pattern and review of the literature.
  • There is a significant potential for confusion of this lesion with other cutaneous lesions, clinically as well as pathologically.
  • In our case, the patient presented with a lesion that clinically resembled a hemangioma, was pathologically interpreted initially to be an angiosarcoma, and finally, the revised pathology was interpreted as an aneurysmal variant of a fibrous histiocytoma.
  • Caution is warranted to avoid misinterpretation of cutaneous fibrohistiocytic tumors.
  • [MeSH-major] Histiocytoma, Benign Fibrous / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aneurysm / pathology. Diagnosis, Differential. Humans. Male. Middle Aged

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  • (PMID = 17004978.001).
  • [ISSN] 0903-4641
  • [Journal-full-title] APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
  • [ISO-abbreviation] APMIS
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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17. Dräger H, Schulte KW, Hengge U, Braunstein S, Ruzicka T, Reifenberger J: [Angiosarcoma after radiation therapy of a hemangioma]. Hautarzt; 2005 Oct;56(10):970-1
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  • [Title] [Angiosarcoma after radiation therapy of a hemangioma].
  • [Transliterated title] Angiosarkom nach Strahlentherapie eines Hämangioms.
  • [MeSH-major] Hemangioma / radiotherapy. Hemangiosarcoma / etiology. Hemangiosarcoma / pathology. Neoplasms, Radiation-Induced / etiology. Neoplasms, Radiation-Induced / pathology. Skin Neoplasms / etiology. Skin Neoplasms / radiotherapy

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  • (PMID = 16143874.001).
  • [ISSN] 0017-8470
  • [Journal-full-title] Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
  • [ISO-abbreviation] Hautarzt
  • [Language] ger
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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18. Ettl T, Kleinheinz J, Mehrotra R, Schwarz S, Reichert TE, Driemel O: Infraorbital cutaneous angiosarcoma: a diagnostic and therapeutic dilemma. Head Face Med; 2008;4:18
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  • [Title] Infraorbital cutaneous angiosarcoma: a diagnostic and therapeutic dilemma.
  • BACKGROUND: A cutaneous angiosarcoma is a rare malignant tumour of vascular endothelial cells with aggressive clinical behaviour and poor prognosis.
  • Diagnosis is often delayed due to its variable and often benign clinical appearance.
  • Histopathologic examination of the specimen diagnosed a cutaneous angiosarcoma.
  • Neither, finally achieved negative margins on permanent sections, nor a following chemotherapy could prevent the recurrence of the disease after five months and the patient's dead 21 months after the first diagnosis.
  • [MeSH-major] Facial Neoplasms / pathology. Hemangiosarcoma / pathology. Neoplasm Recurrence, Local / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Biopsy, Needle. Chemotherapy, Adjuvant. Combined Modality Therapy. Disease Progression. Fatal Outcome. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Staging. Radiotherapy, Adjuvant. Reoperation

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  • (PMID = 18694495.001).
  • [ISSN] 1746-160X
  • [Journal-full-title] Head & face medicine
  • [ISO-abbreviation] Head Face Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2533304
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19. Chen W, Shih CS, Wang YT, Tseng GC, Hsu WH: Angiosarcoma with pulmonary metastasis presenting with spontaneous bilateral pneumothorax in an elderly man. J Formos Med Assoc; 2006 Mar;105(3):238-41
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  • [Title] Angiosarcoma with pulmonary metastasis presenting with spontaneous bilateral pneumothorax in an elderly man.
  • Cutaneous angiosarcoma is a rare and invasive endothelial-derived sarcoma that occurs most frequently in the scalp and facial skin of elderly men.
  • We report a case of angiosarcoma of the scalp with cystic metastasis to the lung in a 63-year-old man, presenting as recurrent bilateral spontaneous pneumothorax.
  • Pneumothorax in the elderly should be differentiated from malignant metastatic lung tumors.

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  • (PMID = 16520841.001).
  • [ISSN] 0929-6646
  • [Journal-full-title] Journal of the Formosan Medical Association = Taiwan yi zhi
  • [ISO-abbreviation] J. Formos. Med. Assoc.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
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20. Conde-Taboada A, Flórez A, De la Torre C, Feal C, García-Doval I, Cruces M: Pseudoangiosarcomatous squamous cell carcinoma of skin arising adjacent to decubitus ulcers. Am J Dermatopathol; 2005 Apr;27(2):142-4
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  • [Title] Pseudoangiosarcomatous squamous cell carcinoma of skin arising adjacent to decubitus ulcers.
  • Pseudoangiosarcomatous, or pseudovascular, squamous cell carcinoma of skin is an unusual form of acantholytic (adenoid, pseudoglandular) squamous cell carcinoma that mimics the histolopathologic appearance of angiosarcoma.
  • The histopathologic examination of a wedge biopsy specimen revealed infiltrative cords of neoplastic cells that formed interanastomosing channels imitating angiosarcoma.
  • To our knowledge, our patient is the first with pseudoangiosarcomatous squamous cell carcinoma of skin developing within decubitus ulcer.
  • [MeSH-major] Carcinoma, Squamous Cell / complications. Pressure Ulcer / complications. Skin Neoplasms / complications
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Hemangiosarcoma / pathology. Humans. Immunohistochemistry

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  • (PMID = 15798440.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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21. Abbaszadeh F, Clingen PH, Arlett CF, Plowman PN, Bourton EC, Themis M, Makarov EM, Newbold RF, Green MH, Parris CN: A novel splice variant of the DNA-PKcs gene is associated with clinical and cellular radiosensitivity in a patient with xeroderma pigmentosum. J Med Genet; 2010 Mar;47(3):176-81
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  • A patient with xeroderma pigmentosum complementation group C, with a scalp angiosarcoma, exhibited dramatic clinical radiosensitivity following radiotherapy, resulting in death.
  • A fibroblast cell line from non-affected skin (XP14BRneo17) was hypersensitive to ionising radiation and defective in DNA DSB repair.
  • [MeSH-major] DNA-Activated Protein Kinase / physiology. Head and Neck Neoplasms / radiotherapy. Hemangiosarcoma / radiotherapy. Nuclear Proteins / physiology. Radiation Tolerance / genetics. Skin Neoplasms / radiotherapy. Xeroderma Pigmentosum / genetics

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  • (PMID = 19797196.001).
  • [ISSN] 1468-6244
  • [Journal-full-title] Journal of medical genetics
  • [ISO-abbreviation] J. Med. Genet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Isoenzymes; 0 / Nuclear Proteins; 0 / Protein Isoforms; EC 2.7.11.1 / DNA-Activated Protein Kinase; EC 2.7.11.1 / PRKDC protein, human
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22. Le Corre Y, Avenel-Audran M, Croué A, Steff M, Verret JL: [Cutaneous angiosarcoma of the leg without lymphoedema]. Ann Dermatol Venereol; 2008 Jun-Jul;135(6-7):488-91
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  • [Title] [Cutaneous angiosarcoma of the leg without lymphoedema].
  • [Transliterated title] Angiosarcome cutané de jambe sans lymphoedème associé.
  • BACKGROUND: Cutaneous angiosarcoma is a rare aggressive vascular neoplasm with a poor prognosis, seen chiefly in elderly subjects and usually on the scalp or face.
  • Histological examination showed vascular channels lined with atypical cells consistent with a diagnosis of angiosarcoma.
  • DISCUSSION: The leg is a rare site of cutaneous angiosarcoma.
  • [MeSH-major] Hemangiosarcoma. Leg. Skin Neoplasms
  • [MeSH-minor] Aged, 80 and over. Amputation. Female. Follow-Up Studies. Humans. Skin / pathology. Time Factors. Tomography, X-Ray Computed

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  • (PMID = 18598799.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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23. De Smet S, Vandermeeren L, Christiaens MR, Samson I, Stas M, Van Limbergen E, De Wever I: Radiation-induced sarcoma: analysis of 46 cases. Acta Chir Belg; 2008 Sep-Oct;108(5):574-9
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  • [Title] Radiation-induced sarcoma: analysis of 46 cases.
  • A retrospective analysis was performed of 46 cases of sarcoma treated in our institution between 1989 and 2007 that occurred in a previously irradiated area.
  • The interval between irradiation and the diagnosis of sarcoma ranged from 1 to 54 years (median 15 y).
  • The most common clinical findings were a mass, pain and skin dislocation.
  • Angiosarcoma and sarcoma non-otherwise-specified were the most common histological types.
  • Stage and location of the sarcoma were other prognostic factors.
  • [MeSH-major] Neoplasms, Radiation-Induced / mortality. Neoplasms, Radiation-Induced / surgery. Sarcoma / mortality. Sarcoma / surgery
  • [MeSH-minor] Abdominal Neoplasms / mortality. Abdominal Neoplasms / pathology. Abdominal Neoplasms / surgery. Adult. Aged. Aged, 80 and over. Extremities. Female. Head and Neck Neoplasms / mortality. Head and Neck Neoplasms / pathology. Head and Neck Neoplasms / surgery. Humans. Lung Neoplasms / mortality. Lung Neoplasms / pathology. Lung Neoplasms / surgery. Male. Middle Aged. Neoplasm Metastasis. Pelvic Neoplasms / mortality. Pelvic Neoplasms / pathology. Pelvic Neoplasms / surgery. Retrospective Studies. Thoracic Neoplasms / mortality. Thoracic Neoplasms / pathology. Thoracic Neoplasms / surgery. Young Adult

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  • (PMID = 19051469.001).
  • [ISSN] 0001-5458
  • [Journal-full-title] Acta chirurgica Belgica
  • [ISO-abbreviation] Acta Chir. Belg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Belgium
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24. Sutton VR, Hopkins BJ, Eble TN, Gambhir N, Lewis RA, Van den Veyver IB: Facial and physical features of Aicardi syndrome: infants to teenagers. Am J Med Genet A; 2005 Oct 15;138A(3):254-8
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  • Aicardi syndrome is a sporadic disorder that affects primarily females and is hypothesized to be caused by heterozygous mutations in an X-linked gene.
  • Various skin lesions (including multiple nevi, skin tags, hemangiomas, one giant melanotic nevus, and a history of a previously removed angiosarcoma) were present in 8/40 (20%).


25. Gengler C, Coindre JM, Leroux A, Trassard M, Ranchère-Vince D, Valo I, Michels JJ, Guillou L: Vascular proliferations of the skin after radiation therapy for breast cancer: clinicopathologic analysis of a series in favor of a benign process: a study from the French Sarcoma Group. Cancer; 2007 Apr 15;109(8):1584-98
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  • [Title] Vascular proliferations of the skin after radiation therapy for breast cancer: clinicopathologic analysis of a series in favor of a benign process: a study from the French Sarcoma Group.
  • BACKGROUND: Cutaneous vascular proliferations that occur in the field of prior radiotherapy include angiosarcoma and small, cutaneous lesions with a pseudosarcomatous pattern that previously were reported as atypical vascular lesions or benign lymphangiomatous papules.
  • Data from all patients were retrieved from the files of the French Sarcoma Group.
  • Follow-up information was available for 31 patients (median follow-up, 48 months): Five women developed new cutaneous lesions, and 1 woman had spontaneous regression of her lesions.
  • None of the patients developed cutaneous angiosarcoma.
  • CONCLUSIONS: Although vascular proliferations in irradiated skin may mimic angiosarcoma morphologically, the large majority of these lesions showed a benign clinical outcome.
  • [MeSH-major] Breast Neoplasms / radiotherapy. Lymphangioma / pathology. Neoplasms, Radiation-Induced / pathology. Radiotherapy / adverse effects. Skin / blood supply. Skin / radiation effects. Skin Neoplasms / etiology. Skin Neoplasms / pathology


26. Al Dhaybi R, Agoumi M, Powell J, Dubois J, Kokta V: Lymphangiosarcoma complicating extensive congenital mixed vascular malformations. Lymphat Res Biol; 2010 Sep;8(3):175-9
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  • Pediatric hepatic angiosarcoma is a very rare malignant vascular tumor.
  • A few cases have shown pediatric hepatic angiosarcoma occurring on a background of preexisting vascular lesions.
  • We report the case of a newborn girl who presented extensive limbs and upper trunk cutaneous mixed vascular malformations at birth.
  • Cutaneous biopsies revealed complex vascular malformations with a significant lymphatic component.
  • Compressive body suit therapy led to regression of the limbs' cutaneous vascular malformations.
  • The autopsy's pathological examination revealed a hepatic-based angiosarcoma with plurimetastatic dissemination to the spleen, lungs, peritoneum, pleura, mesenteric linings as well as the serosa of the stomach and small intestine.
  • Multiple cutaneous and visceral complex capillaro-lymphatico-venous malformations were also identified.
  • We hypothesize that these multiple extensive mixed vascular malformations were associated with chronic lymphedema which probably predisposed to the development of the angiosarcoma in our patient.
  • [MeSH-minor] Autopsy. Fatal Outcome. Female. Humans. Infant. Infant, Newborn. Skin Diseases, Vascular / complications. Skin Diseases, Vascular / congenital. Skin Diseases, Vascular / drug therapy

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  • (PMID = 20863270.001).
  • [ISSN] 1557-8585
  • [Journal-full-title] Lymphatic research and biology
  • [ISO-abbreviation] Lymphat Res Biol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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27. Lazova R, McNiff JM, Glusac EJ, Godic A: Promontory sign--present in patch and plaque stage of angiosarcoma! Am J Dermatopathol; 2009 Apr;31(2):132-6
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  • [Title] Promontory sign--present in patch and plaque stage of angiosarcoma!
  • Kaposi sarcoma is characterized by a proliferation of irregular jagged vascular channels, which partly surround preexisting blood vessels in some areas.
  • Cutaneous angiosarcoma (AS) is a malignant vascular neoplasm comprised of a meshwork of anastomosing irregular dilated vessels between collagen bundles and around skin appendages, lined by atypical endothelial cells.
  • We retrieved all cases of cutaneous AS from the files of Yale Dermatopathology Laboratory between 1990 and 2007.
  • The lesions were divided histologically in a patch, plaque, or tumor stage according to the depth of invasion of malignant cells.
  • The presence of promontory sign has not been emphasized in lesions other than Kaposi sarcoma, but seems to be a feature that is not uncommon in patch/plaque stage AS.
  • [MeSH-major] Dermis / pathology. Endothelial Cells / pathology. Hemangiosarcoma / pathology. Sarcoma, Kaposi / pathology. Skin Neoplasms / pathology

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  • (PMID = 19318797.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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28. Gherardi G, Rossi S, Perrone S, Scanni A: Angiosarcoma after breast-conserving therapy: fine-needle aspiration biopsy, immunocytochemistry, and clinicopathologic correlates. Cancer; 2005 Jun 25;105(3):145-51
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  • [Title] Angiosarcoma after breast-conserving therapy: fine-needle aspiration biopsy, immunocytochemistry, and clinicopathologic correlates.
  • BACKGROUND: Angiosarcoma that arises after breast-conserving therapy can present clinically as a cutaneous and/or subcutaneous breast lump, which is misinterpreted easily as a recurrence of carcinoma.
  • To the authors' knowledge, the role of fine-needle aspiration (FNA) cytology in the early diagnosis of this life-threatening complication of breast carcinoma therapy has not been established fully.
  • METHODS: The authors studied three new patients with this type of secondary angiosarcoma diagnosed by FNA biopsy and immunocytochemistry, reviewed the literature on the topic, and examined relevant differential diagnostic issues.
  • RESULTS: Patients presented with a discrete skin lump that had arisen several years after breast-conservative therapy for early-stage breast carcinoma near the scar from the previous surgery.
  • Immunostaining of smears, however, provided conclusive evidence of the endothelial differentiation of tumor cells, and an FNA diagnosis of angiosarcoma was rendered in all patients.
  • The histopathology of all surgically excised tumors confirmed the diagnosis of high-grade angiosarcoma.
  • CONCLUSIONS: Based on the authors' experience, the FNA cytologic appearance of angiosarcoma that presented as a breast skin nodule in a breast carcinoma survivor easily could have been misinterpreted as carcinoma.
  • A correct diagnosis of this tumor relies on the proper evaluation of clinical findings and, as also shown by a review of the literature, requires immunocytochemical evidence of endothelial differentiation.
  • [MeSH-major] Biopsy, Fine-Needle. Breast Neoplasms / pathology. Breast Neoplasms / surgery. Hemangiosarcoma / secondary. Mastectomy, Segmental / adverse effects. Skin Neoplasms / secondary
  • [MeSH-minor] Aged. Aged, 80 and over. Carcinoma in Situ / pathology. Carcinoma in Situ / surgery. Carcinoma, Ductal, Breast / secondary. Carcinoma, Ductal, Breast / surgery. Carcinoma, Lobular / secondary. Carcinoma, Lobular / surgery. Female. Humans. Immunohistochemistry. Neoplasm Staging. Prognosis. Risk Assessment. Sampling Studies. Sensitivity and Specificity. Survival Rate

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  • (PMID = 15844179.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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29. Terada T: Fatal poorly differentiated angiosarcoma of the scalp. Int J Clin Exp Pathol; 2010;3(5):541-4
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  • [Title] Fatal poorly differentiated angiosarcoma of the scalp.
  • Cutaneous angiosarcoma is a very rare but aggressive tumor.
  • Angiosarcoma of the scalp is very rare, and a review of the world literature revealed less than 60 cases.
  • Here, the author reports a case of poorly differentiated angiosarcoma of the scalp.
  • The pathological diagnosis was very difficult.
  • The biopsy showed proliferation of malignant spindle cells in the dermis.
  • Intracytoplasmic vacuoles were recognized in the malignant tumor cells in some places.
  • Immunohistochemically, the malignant spindle cells were positive for factor VIII-related antigen (F-VIII-RA), Ulex lectin, CD31, CD34, vimentin, p53 protein.
  • A pathologic diagnosis of angiosarcoma of the scalp was made.
  • [MeSH-major] Hemangiosarcoma / pathology. Scalp / pathology. Skin Neoplasms / pathology

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  • [Cites] Cancer. 1987 Mar 1;59(5):1046-57 [3815265.001]
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  • (PMID = 20606736.001).
  • [ISSN] 1936-2625
  • [Journal-full-title] International journal of clinical and experimental pathology
  • [ISO-abbreviation] Int J Clin Exp Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC2897108
  • [Keywords] NOTNLM ; CD31 / CD34 / Cutaneous angiosarcoma / Ulex lectin / for factor VIII-related antigen (F-VIII-RA) / p53 protein / scalp / vimentin
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30. Chapas AM, Askarian F, Demierre MF, Stefanato CM: Well-differentiated angiosarcoma of the scalp: an unusual clinical presentation. J Am Acad Dermatol; 2005 Feb;52(2 Suppl 1):58-9
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  • [Title] Well-differentiated angiosarcoma of the scalp: an unusual clinical presentation.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Hemangiosarcoma / pathology. Scalp / pathology. Skin Neoplasms / pathology

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  • (PMID = 15692518.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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31. Isoda H, Imai M, Inagawa S, Miura K, Sakahara H: Magnetic resonance imaging findings of angiosarcoma of the scalp. J Comput Assist Tomogr; 2005 Nov-Dec;29(6):858-62
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  • [Title] Magnetic resonance imaging findings of angiosarcoma of the scalp.
  • OBJECTIVE: The purpose of this study was to investigate the magnetic resonance (MR) imaging findings of angiosarcoma of the scalp retrospectively.
  • METHODS: Eight patients with angiosarcoma of the scalp were included in this study.
  • CONCLUSIONS: Magnetic resonance imaging was useful in determining the extent of angiosarcoma of the scalp because it visualized the tumor invasion into surrounding structures that could not be seen on physical inspection.
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Hemangiosarcoma / diagnosis. Magnetic Resonance Imaging / methods. Scalp / pathology. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Observer Variation. Retrospective Studies

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  • (PMID = 16272865.001).
  • [ISSN] 0363-8715
  • [Journal-full-title] Journal of computer assisted tomography
  • [ISO-abbreviation] J Comput Assist Tomogr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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32. Veliz M, Chang V, Kasimis B, Choe JK: Durable response of angiosarcoma of the face and scalp to docetaxel. Clin Oncol (R Coll Radiol); 2007 Apr;19(3):210
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  • [Title] Durable response of angiosarcoma of the face and scalp to docetaxel.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Hemangiosarcoma / drug therapy. Skin Neoplasms / drug therapy. Taxoids / therapeutic use

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  • (PMID = 17359910.001).
  • [ISSN] 0936-6555
  • [Journal-full-title] Clinical oncology (Royal College of Radiologists (Great Britain))
  • [ISO-abbreviation] Clin Oncol (R Coll Radiol)
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Taxoids; 15H5577CQD / docetaxel
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33. Moore A, Hendon A, Hester M, Samayoa L: Secondary angiosarcoma of the breast: can imaging findings aid in the diagnosis? Breast J; 2008 May-Jun;14(3):293-8
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  • [Title] Secondary angiosarcoma of the breast: can imaging findings aid in the diagnosis?
  • We present three cases of secondary angiosarcoma of the breast in the setting of prior breast irradiation.
  • Imaging findings include cutaneous nodules and progressive skin or trabecular thickening in an area of the breast separate from the patient's original breast carcinoma.
  • These imaging findings may enable the radiologist to suggest this diagnosis, even when the clinical presentation is more benign.
  • [MeSH-major] Breast Neoplasms / diagnosis. Hemangiosarcoma / diagnosis. Neoplasm Recurrence, Local / diagnosis. Neoplasms, Radiation-Induced / diagnosis

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  • (PMID = 18476885.001).
  • [ISSN] 1524-4741
  • [Journal-full-title] The breast journal
  • [ISO-abbreviation] Breast J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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34. Katagata Y, Hirayama T: Unexpected expression of Hsp47, a replacement of one amino acid (Val 7 Leu) in the amino terminal region, in cultured human tumorigenic cell lines. J Dermatol Sci; 2008 Jan;49(1):33-8
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  • OBJECTIVE: This study was intended to elucidate how the above glycoprotein co-exists in the K fraction prepared from ISO-HAS (cultured angiosarcoma cell line).
  • [MeSH-major] Carcinoma, Squamous Cell / physiopathology. HSP47 Heat-Shock Proteins / genetics. HSP47 Heat-Shock Proteins / metabolism. Keratinocytes / physiology. Skin Neoplasms / physiopathology
  • [MeSH-minor] Amino Acid Sequence. Amino Acid Substitution / physiology. Cell Line, Transformed. Fibrosarcoma. Gene Expression Regulation, Neoplastic. Glycosylation. HeLa Cells. Hemangiosarcoma. Humans. Keratins / metabolism. Melanoma. Molecular Sequence Data. Periodic Acid-Schiff Reaction

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  • (PMID = 18293509.001).
  • [ISSN] 0923-1811
  • [Journal-full-title] Journal of dermatological science
  • [ISO-abbreviation] J. Dermatol. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / HSP47 Heat-Shock Proteins; 0 / SERPINH1 protein, human; 68238-35-7 / Keratins
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35. Zhang W, He J, Wang J, Bai H, Zhang X, Zhang G, Ren Y, Wang K, Xu J, Niu L, Zhou Y, Chen W: Ulcerated epithelioid hemangioendothelioma of the right armpit in childhood. J Pediatr Hematol Oncol; 2009 Aug;31(8):595-8
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  • This low-grade malignant vascular tumor was described as a distinctive condition in 1982 by Weiss and Enzinger.
  • Although the tumor is classified in between an angiolymphoid hyperplasia with eosinophilia and an epithelioid angiosarcoma, it sometimes takes a clinical course resembling that of angiosarcoma.
  • On the basis of these findings the diagnosis of EHE was made.
  • As our case report shows, it is possibility that cutaneous ulceration of a malignant tumor such as EHE should be considered, even in children.
  • [MeSH-major] Arm / pathology. Hemangioendothelioma, Epithelioid / pathology. Skin Neoplasms / pathology. Ulcer / pathology


36. Peramiquel L, Barnadas MA, Sancho J, Curell R, Alonso MC, Fuentes MJ, Pernas S, Gómez A, Alomar A: [Angiosarcoma in an irradiated breast: a case description]. Actas Dermosifiliogr; 2005 Nov;96(9):602-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Angiosarcoma in an irradiated breast: a case description].
  • [Transliterated title] Angiosarcoma en mama irradiada: descripción de un caso.
  • Post-radiotherapy cutaneous angiosarcomas have been described in different locations, including the breast.
  • We present a case of cutaneous angiosarcoma of the breast, diagnosed 6 years after a carcinoma of the breast had been treated with radiation.
  • The histology of the skin biopsies showed angiomatous proliferation throughout the entire dermis, with no cellular atypia.
  • Considering the patient's symptoms, history and the changes observed via mammography, it was decided to completely excise the lesion followed by a simple mastectomy, with the diagnosis of angiosarcoma being confirmed.
  • Despite this fact, two years and one month later, the angiosarcoma recurred on the internal area of the mastectomy scar.
  • This complication usually appears 5-10 years after treatment with radiotherapy, so angiosarcoma should be ruled out if any angiomatous lesions later appear on skin that had been irradiated.
  • [MeSH-major] Breast Neoplasms / etiology. Breast Neoplasms / radiotherapy. Carcinoma, Ductal, Breast / radiotherapy. Hemangiosarcoma / etiology. Neoplasms, Radiation-Induced / etiology. Skin Neoplasms / etiology

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  • (PMID = 16476306.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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37. Silvariño R, Mérola V, Fígoli L, Romero C, Lapiedra J, Alonso J: [Stewart-Treves syndrome: report of one case]. Rev Med Chil; 2010 Jan;138(1):73-6
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  • Angiosarcomas are malignant tumors derived from the endothelium of blood vessel (hemangiosarcomas) or lymph vessels (lymphangiosarcomas).
  • It appears as nodular skin lesions that grow, multiply quickly and frequently metastasize.
  • We report a 40-year-old mole with an angiosarcoma associated with primary chronic lower limb lymph edema.
  • A biopsy of one of the skin lesions disclosed an angiosarcoma, diagnosis that was confirmed with immuno-histochemistry Chemotherapy was started but the patient died five months after the diagnosis.

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  • (PMID = 20361154.001).
  • [ISSN] 0034-9887
  • [Journal-full-title] Revista médica de Chile
  • [ISO-abbreviation] Rev Med Chil
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Chile
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38. Long CT, Luong R: What's your diagnosis. Tail mass in a mouse. Cutaneous hemangiosarcoma. Lab Anim (NY); 2009 Feb;38(2):49-51
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  • [Title] What's your diagnosis. Tail mass in a mouse. Cutaneous hemangiosarcoma.
  • [MeSH-major] Hemangiosarcoma / veterinary. Skin Neoplasms / veterinary
  • [MeSH-minor] Angiomatosis / diagnosis. Animals. Animals, Outbred Strains. Diagnosis, Differential. Fatal Outcome. Female. Hemangioma / diagnosis. Hematoma / diagnosis. Mice. Tail

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  • (PMID = 19165190.001).
  • [ISSN] 0093-7355
  • [Journal-full-title] Lab animal
  • [ISO-abbreviation] Lab Anim (NY)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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39. Gambassi G, Semeraro R, Suma V, Sebastio A, Incalzi RA: Aggressive behavior of classical Kaposi's sarcoma and coexistence with angiosarcoma. J Gerontol A Biol Sci Med Sci; 2005 Apr;60(4):520-3
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  • [Title] Aggressive behavior of classical Kaposi's sarcoma and coexistence with angiosarcoma.
  • Histology allowed a diagnosis of the classical form of Kaposi's sarcoma; the serology test result for HIV was negative, whereas the associated human herpes virus type 8 was detected by polymerase chain reaction on the skin sample.
  • Over the subsequent 6 months, skin lesions become vegetative and partially necrotic, and extended to the hands and eyelids.
  • Chemotherapy with vinblastine appeared to stabilize the cutaneous disease, but the patient developed a massive gastrointestinal hemorrhage secondary to dissemination to the stomach.
  • Twelve months after the onset of the disease, vegetative and easily bleeding lesions progressively occluded the mouth of the patient: histological features were consistent with a low-grade angiosarcoma distinct from that of Kaposi's sarcoma.
  • This case illustrates that, even in its classical form, Kaposi's sarcoma may be a malignant, rapidly progressing tumor.
  • LEARNING POINTS: a) The extent and rate of spread of initial skin lesions should be considered to be early signs of aggressive dissemination, even in the absence of other variables (i.e., histological pattern, human herpes virus type 8 positive mononuclear cells) associated with progression of the disease.
  • c) When classical Kaposi's sarcoma displays aggressive behavior a second, primary malignant tumor arising from the vascular tissue should be investigated.
  • TAKE-HOME MESSAGE: Even in its classical form, Kaposi's sarcoma may be a malignant, rapidly progressing tumor with visceral involvement; also, a second malignancy may occur in nearly one patient of four.
  • Because localized skin lesions can regress completely with radiotherapy, watchful waiting is probably inappropriate in most cases.
  • [MeSH-major] Foot Diseases / pathology. Hemangiosarcoma / pathology. Neoplasms, Multiple Primary / pathology. Palatal Neoplasms / pathology. Sarcoma, Kaposi / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Fatal Outcome. Follow-Up Studies. Humans. Male. Neoplasm Invasiveness

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  • (PMID = 15933395.001).
  • [ISSN] 1079-5006
  • [Journal-full-title] The journals of gerontology. Series A, Biological sciences and medical sciences
  • [ISO-abbreviation] J. Gerontol. A Biol. Sci. Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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40. Forton GE, Van Parys G, Hertveldt K: Primary angiosarcoma of the non-irradiated parotid gland: a most uncommon, highly malignant tumor. Eur Arch Otorhinolaryngol; 2005 Mar;262(3):173-7
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  • [Title] Primary angiosarcoma of the non-irradiated parotid gland: a most uncommon, highly malignant tumor.
  • This case report discusses the clinical presentation, imaging, surgery and further treatment and course of a primary angiosarcoma of a non-irradiated parotid gland.
  • [MeSH-major] Hemangiosarcoma / secondary. Parotid Neoplasms / pathology. Skin Neoplasms / secondary
  • [MeSH-minor] Aged. Aged, 80 and over. Antigens, CD45 / immunology. Humans. Keratins / immunology. Magnetic Resonance Imaging. Male. Neoplasm Staging. Neoplasms, Second Primary / diagnostic imaging. Neoplasms, Second Primary / pathology. Tomography, X-Ray Computed

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  • [Cites] Head Neck. 1992 Jan-Feb;14(1):1-7 [1624288.001]
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  • (PMID = 15133686.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 68238-35-7 / Keratins; EC 3.1.3.48 / Antigens, CD45
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41. Donghi D, Kerl K, Dummer R, Schoenewolf N, Cozzio A: Cutaneous angiosarcoma: own experience over 13 years. Clinical features, disease course and immunohistochemical profile. J Eur Acad Dermatol Venereol; 2010 Oct;24(10):1230-4
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  • [Title] Cutaneous angiosarcoma: own experience over 13 years. Clinical features, disease course and immunohistochemical profile.
  • BACKGROUND: Cutaneous angiosarcoma (AS) is a rare malignant tumour of endothelial origin with very poor prognosis, frequent recurrences and high metastatic potential.
  • RESULTS AND CONCLUSIONS: Cutaneous AS was clinically diagnosed in 4 of 9 patients, while systemic lupus erythematosus was the most common misdiagnosis.
  • [MeSH-major] Hemangiosarcoma / diagnosis. Hemangiosarcoma / pathology. Skin Neoplasms / diagnosis. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Antibodies, Monoclonal / metabolism. Antibodies, Monoclonal, Murine-Derived. Biomarkers, Tumor / metabolism. Combined Modality Therapy. Diagnosis, Differential. Female. Humans. Ki-67 Antigen / metabolism. Lupus Erythematosus, Systemic / diagnosis. Male. Middle Aged. Prognosis. Retrospective Studies

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  • (PMID = 20236193.001).
  • [ISSN] 1468-3083
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / monoclonal antibody D2-40
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42. Zhang G, Lu Q, Yin H, Wen H, Su Y, Li D, Xiao R: A case of retiform-hemangioendothelioma with unusual presentation and aggressive clinical features. Int J Clin Exp Pathol; 2010;3(5):528-33
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  • Retiform hemangioendothelioma (RH) is an extremely rare low-grade angiosarcoma mainly involving the skin and subcutaneous tissue.
  • Here we reported a case of RH in a 61-year-old Chinese woman who presented with a rapid growing cutaneous plaque-like lesion on her right scalp, followed by another lesion behind the right ear.
  • She underwent wide excision and skin engraftment.
  • Three months post surgery, she experienced tumor recurrence, and died 9 months after the initial diagnosis.
  • [MeSH-major] Hemangioendothelioma / pathology. Hemangiosarcoma / pathology. Scalp / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Female. Humans. Immunohistochemistry. Middle Aged. Neoplasm Recurrence, Local / pathology

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  • (PMID = 20606734.001).
  • [ISSN] 1936-2625
  • [Journal-full-title] International journal of clinical and experimental pathology
  • [ISO-abbreviation] Int J Clin Exp Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2897105
  • [Keywords] NOTNLM ; Retiform hemangioendothelioma / headache / recurrence
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43. Elawar A, Dandurand M, Jumez N, Delfour C, Branchereau P, Stoebner P, Meunier L: [Cutaneous metastasis revealing epithelioid angiosarcoma of the abdominal aorta]. Ann Dermatol Venereol; 2010 Feb;137(2):111-6
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  • [Title] [Cutaneous metastasis revealing epithelioid angiosarcoma of the abdominal aorta].
  • [Transliterated title] Métastases cutanées révélatrices d'un angiosarcome épithélioïde de l'aorte abdominale.
  • We report a case revealed by skin metastasis.
  • CASE REPORT: An 85-year-old man presented skin tumours associated with deterioration of his general condition and intense pain of the right lower limb.
  • Histological examination of a nodule showed proliferation of malignant cells with expression of vimentin, CD 31, cytokeratins AE1/AE3 and cytokeratin 7.
  • Moreover, skin and osseous F-FDG uptake was seen.
  • These findings suggested a diagnosis of EAS of the aorta with skin and osseous metastasis and vascular emboli.
  • Skin metastasis causes papular eruption, nodules and peripheral vascular disease.
  • Our case report emphasizes four key points: the diagnostic value of an association of localized malignant skin tumours, extensive livedo, ipsilateral distal ischaemia, deterioration of the general condition and intense pain; the diagnostic value of endothelial markers, especially CD31, and potentially misleading co-expression of cytokeratin markers; in selected cases, additional imaging, such as PET scans, performed in our case for the first time prior to surgery of the aorta, may be helpful for the diagnosis of such neoplastic lesions of the aortic wall.
  • [MeSH-major] Aorta, Abdominal / pathology. Hemangiosarcoma / pathology. Hemangiosarcoma / secondary. Skin Neoplasms / secondary. Vascular Neoplasms / pathology

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  • [Copyright] Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20171432.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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44. Ward KA, Ecker PM, White RR, Melnik TE, Gulbahce EH, Wilke MS, Sangueza OP: Papillary intralymphatic angioendothelioma of the thigh: A case report and review of the literature. Dermatol Online J; 2010;16(4):4
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  • The term angiosarcoma, encompasses several neoplasms, all of which exhibit a malignant process derived from endothelial cells of the vessels.
  • The most common form of angiosarcoma is highly aggressive, often fatal, and usually affects the head and neck region of elderly white men.
  • Other low-grade forms of angiosarcoma, including papillary intralymphatic angioendothelioma, also known as Dabska tumor, are less invasive, affect a wider age range, and offer a better prognosis.
  • There are several predisposing factors that increase the risk of angiosarcoma and include chronic lymphedema of the extremities, preexisting vascular lesions, and prior radiation, often as therapy for other malignancies.
  • We report an unusual case of a very small, low-grade angiosarcoma on the thigh of an adult female with no known predisposing risk factors.
  • [MeSH-major] Hemangiosarcoma / diagnosis. Skin Neoplasms / diagnosis. Thigh
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Middle Aged

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  • (PMID = 20409411.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 27
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45. Maeda T, Uchino K, Otani T, Ueda Y: [Cutaneous angiosarcoma with difficulty in differential diagnosis of thrombocytopenia]. Rinsho Ketsueki; 2010 Jun;51(6):402-6
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  • [Title] [Cutaneous angiosarcoma with difficulty in differential diagnosis of thrombocytopenia].
  • An 87-year-old man was referred to our hospital because of sustained bleeding from head skin lesions after trauma.
  • Based on the tentative diagnosis of immune thrombocytopenic purpura (ITP), immunosuppressive drugs and high-dose immunoglobulin were administered; however, the platelet count did not recover, and was followed by severe DIC, resulting in a fatal outcome due to massive bleeding from the scalp.
  • Histopathological examination of autopsy samples of skin lesions revealed angiosarcoma, suggesting that Kasabach-Merritt syndrome (KMS) complicated with DIC, but not ITP, was the primary cause of thrombocytopenia.
  • Although KMS is commonly accompanied with hemangioma in infants, it is extremely rare in patients with angiosarcoma, which is an uncommon malignant neoplasm.
  • In this case, our correct diagnosis of thrombocytopenia was difficult because of the unusual clinical setting, indicating that careful interpretation of physical, laboratory and pathological examinations is mandatory for correct diagnosis of thrombocytopenia of unknown etiology.
  • [MeSH-major] Hemangiosarcoma / complications. Hemangiosarcoma / diagnosis. Skin Neoplasms / complications. Skin Neoplasms / diagnosis. Thrombocytopenia / diagnosis. Thrombocytopenia / etiology
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. Disseminated Intravascular Coagulation / etiology. Fatal Outcome. Hemangioma / complications. Humans. Male. Syndrome

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  • (PMID = 20622486.001).
  • [ISSN] 0485-1439
  • [Journal-full-title] [Rinshō ketsueki] The Japanese journal of clinical hematology
  • [ISO-abbreviation] Rinsho Ketsueki
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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46. Santos P, Pinto GM, Pereira A, Cruz T, Afonso A, Cardoso J: Sequential treatment of angiosarcoma of the back with liposomal doxorubicin and radiotherapy. J Eur Acad Dermatol Venereol; 2005 Nov;19(6):779-80
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  • [Title] Sequential treatment of angiosarcoma of the back with liposomal doxorubicin and radiotherapy.
  • [MeSH-major] Antibiotics, Antineoplastic / therapeutic use. Back. Doxorubicin / therapeutic use. Hemangiosarcoma / drug therapy. Hemangiosarcoma / radiotherapy. Skin Neoplasms / drug therapy. Skin Neoplasms / radiotherapy

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  • (PMID = 16268901.001).
  • [ISSN] 0926-9959
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Liposomes; 80168379AG / Doxorubicin
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47. Fernandez-Flores A, Rodriguez R: Promontory sign in a reactive benign vascular proliferation. Am J Dermatopathol; 2010 Oct;32(7):700-3
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  • The promontory sign was described 27 years ago and it was claimed to be useful in the diagnosis of early stages of Kaposi sarcoma.
  • However, it is not pathognomonic, because it has also been described in angiosarcoma and in benign vascular tumors.
  • We report the case of a vascular cutaneous lesion on the breast of a 75-year-old woman, which had a benign clinical behavior, and presented with the promontory sign.
  • [MeSH-major] Breast Diseases / pathology. Skin Diseases / pathology. Vascular Diseases / pathology
  • [MeSH-minor] Aged. Blood Vessels / pathology. Breast Neoplasms / pathology. Cardiomyopathy, Hypertrophic / complications. Diagnosis, Differential. Female. Humans. Hypothyroidism / complications

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  • (PMID = 20577080.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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48. Furusawa T, Matsumoto I, Oda M, Yachi T, Miyazu K, Watanabe G, Zen Y, Minato H, Shibata Y, Koda W: [Intractable pneumothorax secondary to pulmonary metastasis of angiosarcoma]. Kyobu Geka; 2008 Aug;61(9):779-83
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  • [Title] [Intractable pneumothorax secondary to pulmonary metastasis of angiosarcoma].
  • He had a previous history of angiosarcoma of the scalp, and had received local resection and chemoradiotherapy.
  • Although surgical resection for pneumothorax secondary to metastatic lung cancer is usually efficient, it is very hard to manage the pneumothorax of metastatic angiosarcoma.
  • [MeSH-major] Hemangiosarcoma / pathology. Lung Neoplasms / complications. Lung Neoplasms / secondary. Pneumothorax / etiology. Scalp. Skin Neoplasms / pathology

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  • (PMID = 18697460.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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49. McAbee KP, Ludwig LL, Bergman PJ, Newman SJ: Feline cutaneous hemangiosarcoma: a retrospective study of 18 cases (1998-2003). J Am Anim Hosp Assoc; 2005 Mar-Apr;41(2):110-6
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  • [Title] Feline cutaneous hemangiosarcoma: a retrospective study of 18 cases (1998-2003).
  • Cutaneous hemangiosarcoma (HSA) has been infrequently reported in dogs and cats.
  • Medical records of 18 cats diagnosed with cutaneous HSA were reviewed.
  • Age at the time of diagnosis, breed, sex, tumor location, tumor size, treatment type, survival time, disease-free interval, and cause of death were evaluated.
  • Cats with cutaneous HSA treated with aggressive surgical excision of their tumors may have a good long-term prognosis.
  • [MeSH-major] Cat Diseases / diagnosis. Cat Diseases / surgery. Hemangiosarcoma / veterinary. Skin Neoplasms / veterinary
  • [MeSH-minor] Animals. Cats. Disease-Free Survival. Female. Male. Neoplasm Recurrence, Local / veterinary. Prognosis. Retrospective Studies. Treatment Outcome


50. Ortiz Mendoza CM: [Recurrent breast haematoma after fine needle aspiration biopsy of angiosarcoma]. Ginecol Obstet Mex; 2007 Mar;75(3):164-7
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  • [Title] [Recurrent breast haematoma after fine needle aspiration biopsy of angiosarcoma].
  • [Transliterated title] Hematoma mamario recidivante posterior a la biopsia por aspiración con aguja delgada en un angiosarcoma.
  • It is reported a rare complication after a fine needle aspiration biopsy of a breast angiosarcoma.
  • A fine needle aspiration biopsy was carried out for diagnosis, but only blood was report.
  • After the biopsy the skin showed a violaceous color, the lump was tender, reappeared in three instances and increased its size (15 cm).
  • Four months later a recurrence presented, and a new excision was carried out with a resulting moderately differentiated angiosarcoma, then a simple mastectomy was performed for definitive treatment.
  • A recurrent haematoma after a fine needle aspiration biopsy of a breast tumor mandates to rule out an angiosarcoma.
  • [MeSH-major] Biopsy, Fine-Needle / adverse effects. Breast / injuries. Breast Neoplasms / pathology. Hemangiosarcoma / pathology. Hematoma / etiology

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  • (PMID = 17547091.001).
  • [ISSN] 0300-9041
  • [Journal-full-title] Ginecología y obstetricia de México
  • [ISO-abbreviation] Ginecol Obstet Mex
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Mexico
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51. Puizina-Ivić N, Bezić J, Marasović D, Gotovac V, Carija A, Bozić M: Angiosarcoma arising in sclerodermatous skin. Acta Dermatovenerol Alp Pannonica Adriat; 2005 Mar;14(1):20-5
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  • [Title] Angiosarcoma arising in sclerodermatous skin.
  • We report a case of cutaneous angiosarcoma in a 77-year-old female patient with systemic sclerosis.
  • Since the conservative therapy failed to produce any improvement, a diagnostic skin biopsy was performed.
  • The pathohistological diagnosis was moderately differentiated angiosarcoma.
  • Despite a notable cutaneous improvement, the control check-up revealed the presence of metastases of the lung and liver.
  • This is the first report of cutaneous angiosarcoma occurring in sclerodermatous skin.
  • [MeSH-major] Facial Neoplasms / etiology. Hemangiosarcoma / etiology. Scleroderma, Systemic / complications. Scleroderma, Systemic / physiopathology. Skin Neoplasms / etiology

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  • (PMID = 15818442.001).
  • [ISSN] 1318-4458
  • [Journal-full-title] Acta dermatovenerologica Alpina, Pannonica, et Adriatica
  • [ISO-abbreviation] Acta Dermatovenerol Alp Pannonica Adriat
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Slovenia
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52. Suzuki H, Komatsu A, Fujioka Y, Yamashiro K, Takeda H, Hamada T: Angiosarcoma-like metastatic carcinoma of the liver. Pathol Res Pract; 2010 Jul 15;206(7):484-8
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  • [Title] Angiosarcoma-like metastatic carcinoma of the liver.
  • Two cases of metastatic carcinoma strikingly simulating angiosarcoma in the liver are described.
  • She had undergone surgery for skin cancer three years before.
  • Both cases had an angiosarcoma-like appearance macroscopically and microscopically.
  • Angiosarcoma is the most common sarcoma arising in the liver.
  • Thus, metastatic carcinoma, which resembles angiosarcoma, might be mistaken for angiosarcoma.
  • [MeSH-major] Carcinoma / secondary. Liver Neoplasms / secondary. Skin Neoplasms / pathology. Ureteral Neoplasms / pathology
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. Female. Hemangiosarcoma / pathology. Humans. Immunohistochemistry. Middle Aged

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  • [Copyright] Copyright 2009 Elsevier GmbH. All rights reserved.
  • (PMID = 20097483.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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53. Scalise A, Bertani A, Forlini W, Pierangeli M, Piedimonte A: Cutaneous angiosarcoma of the skin: three rare cases. Plast Reconstr Surg; 2006 Feb;117(2):687-8
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  • [Title] Cutaneous angiosarcoma of the skin: three rare cases.
  • [MeSH-major] Hemangiosarcoma / surgery. Skin Neoplasms / surgery. Surgical Flaps

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  • (PMID = 16462373.001).
  • [ISSN] 1529-4242
  • [Journal-full-title] Plastic and reconstructive surgery
  • [ISO-abbreviation] Plast. Reconstr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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54. Leggio L, Addolorato G, Abenavoli L, Ferrulli A, D'Angelo C, Mirijello A, Vonghia L, Schinzari G, Arena V, Perrone L, Citterio F, Bonomo L, Rapaccini GL, Capelli A, Barone C, Gasbarrini G: Primary renal angiosarcoma: a rare malignancy. A case report and review of the literature. Urol Oncol; 2006 Jul-Aug;24(4):307-12
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  • [Title] Primary renal angiosarcoma: a rare malignancy. A case report and review of the literature.
  • Angiosarcoma is a rare malignant tumor occurring in less than 2% of soft tissue sarcomas.
  • Angiosarcoma involving the kidney usually represents metastasis from skin or visceral primary lesions, while angiosarcoma primarily occurring in the kidney is a very rare neoplasm.
  • In the English literature, from 1942 to the present, only 19 cases of primary kidney angiosarcoma have been reported.
  • A case of primary renal angiosarcoma presenting as a large kidney mass and flank pain occurring after traumatism is reported.
  • [MeSH-major] Hemangiosarcoma / pathology. Kidney Neoplasms / pathology

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  • (PMID = 16818182.001).
  • [ISSN] 1078-1439
  • [Journal-full-title] Urologic oncology
  • [ISO-abbreviation] Urol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 28
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55. Requena L, Santonja C, Stutz N, Kaddu S, Weenig RH, Kutzner H, Menzel T, Cerroni L: Pseudolymphomatous cutaneous angiosarcoma: a rare variant of cutaneous angiosarcoma readily mistaken for cutaneous lymphoma. Am J Dermatopathol; 2007 Aug;29(4):342-50
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  • [Title] Pseudolymphomatous cutaneous angiosarcoma: a rare variant of cutaneous angiosarcoma readily mistaken for cutaneous lymphoma.
  • Cutaneous angiosarcoma is probably the most malignant neoplasm involving the skin.
  • Three clinical variants of cutaneous angiosarcoma are recognized, including angiosarcoma of the scalp and face of elderly patients, angiosarcoma associated with chronic lymphedema, and postirradiation angiosarcoma.
  • Histopathologically, these three variants of angiosarcoma show similar features, which consist of poorly circumscribed, irregularly dilated, and anastomosing vascular channels lined by prominent endothelial cells that dissect through the dermis.
  • In rare instances, cutaneous angiosarcomas may exhibit prominent inflammatory infiltrate, and the neoplasm may be mistaken for an inflammatory process, both from clinical and histopathologic points of view.
  • We describe four examples of cutaneous angiosarcomas with dense lymphocytic infiltrates involving the neoplasm.
  • Cutaneous angiosarcoma with prominent lymphocytic infiltrate may be readily mistaken for cutaneous follicle center cell lymphoma or cutaneous pseudolymphoma.
  • [MeSH-major] Hemangiosarcoma / diagnosis. Lymphoma / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged. Breast Neoplasms / diagnosis. Diagnosis, Differential. Endothelial Cells / pathology. Endothelium, Vascular / pathology. Facial Neoplasms / diagnosis. Female. Humans. Lymphocytes / pathology. Lymphoma, Follicular / diagnosis. Male. Middle Aged. Neovascularization, Pathologic / pathology. Pseudolymphoma / diagnosis. Scalp / pathology. Skin Diseases / diagnosis

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  • (PMID = 17667166.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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56. Ryu DY, Hwang SY, Lee DW, Kim TO, Park DY, Kim GH, Heo J, Kang DH, Song GA, Cho M: [A case of primary angiosarcoma of small intestine presenting as recurrent gastrointestinal bleeding]. Korean J Gastroenterol; 2005 Nov;46(5):404-8
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  • [Title] [A case of primary angiosarcoma of small intestine presenting as recurrent gastrointestinal bleeding].
  • Angiosarcoma is a rare malignant tumor which occurs frequently in the skin and soft subcutis.
  • The diagnosis is often made at an advanced stage.
  • We report a case of primary angiosarcoma of the small intestine presenting as recurrent gastrointestinal bleeding.
  • The ileal mass was diagnosed as angiosarcoma on immunohistochemical stain.
  • He received 3 cycles of chemotherapy, but died 5 months after the diagnosis.
  • [MeSH-major] Gastrointestinal Hemorrhage / etiology. Hemangiosarcoma / diagnosis. Intestinal Neoplasms / diagnosis. Intestine, Small

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  • (PMID = 16301855.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Korea (South)
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57. Gao Z, Chen S: Postradiation angiosarcoma of the skin featuring capillary lobules. Am J Dermatopathol; 2006 Aug;28(4):376
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  • [Title] Postradiation angiosarcoma of the skin featuring capillary lobules.
  • [MeSH-major] Hemangiosarcoma / blood supply. Hemangiosarcoma / pathology

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  • [CommentOn] Am J Dermatopathol. 2005 Aug;27(4):301-5 [16121049.001]
  • (PMID = 16871048.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Comment; Letter
  • [Publication-country] United States
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58. Arbiser JL, Bonner MY, Berrios RL: Hemangiomas, angiosarcomas, and vascular malformations represent the signaling abnormalities of pathogenic angiogenesis. Curr Mol Med; 2009 Nov;9(8):929-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Angiogenesis is a major factor in the development of benign, inflammatory, and malignant processes of the skin.
  • Endothelial cells are the effector cells of angiogenesis, and understanding their response to growth factors and inhibitors is critical to understanding the pathogenesis and treatment of skin disease.
  • Furthermore, we have studied malignant vascular tumors, including hemangioendothelioma and angiosarcoma and have shown distinct signaling abnormalities in these tumors.
  • The incidence of these tumors is expected to rise due to environmental insults, such as radiation and lumpectomy for breast cancer, dietary and industrial carcinogens (hepatic angiosarcoma), and chronic ultraviolet exposure and potential Agent Orange exposure.
  • [MeSH-major] Hemangioma / blood supply. Hemangiosarcoma / blood supply. Neovascularization, Pathologic / pathology. Signal Transduction. Vascular Malformations / physiopathology


59. Chen TJ, Chiou CC, Chen CH, Kuo TT, Hong HS: Metastasis of mediastinal epithelioid angiosarcoma to the finger. Am J Clin Dermatol; 2008;9(3):181-3
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  • [Title] Metastasis of mediastinal epithelioid angiosarcoma to the finger.
  • Epithelioid angiosarcoma (EA) is a rare malignant, vascular tumor that is usually observed in middle-aged and elderly males.
  • Cutaneous metastasis of EA is extremely rare.
  • The skin biopsy specimen revealed metastatic EA.
  • Whenever a patient has metastatic disease, acrometastases should be considered in the differential diagnosis of inflammatory lesions of the digits and a skin biopsy should be performed.
  • [MeSH-major] Fingers / pathology. Hemangioendothelioma, Epithelioid / secondary. Mediastinal Neoplasms / pathology. Skin Neoplasms / secondary
  • [MeSH-minor] Adult. Biopsy. Diagnosis, Differential. Fatal Outcome. Female. Humans

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  • (PMID = 18429648.001).
  • [ISSN] 1175-0561
  • [Journal-full-title] American journal of clinical dermatology
  • [ISO-abbreviation] Am J Clin Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] New Zealand
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60. Nagano T, Yamada Y, Ikeda T, Kanki H, Kamo T, Nishigori C: Docetaxel: a therapeutic option in the treatment of cutaneous angiosarcoma: report of 9 patients. Cancer; 2007 Aug 1;110(3):648-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Docetaxel: a therapeutic option in the treatment of cutaneous angiosarcoma: report of 9 patients.
  • BACKGROUND: Effective treatment options are limited for patients with cutaneous angiosarcoma (AS).
  • Another taxane drug, paclitaxel, reportedly had unique activity in the treatment of AS of the scalp and neck and acquired immunodeficiency syndrome-related Kaposi sarcoma.
  • Therefore, the authors hypothesized that docetaxel may be of value in the treatment of cutaneous AS that is resistant to conventional therapy.
  • This treatment regimen was received by 9 patients with cutaneous AS who were treated at Kobe University Hospital between January 2003 and October 2006.
  • CONCLUSIONS: The current study demonstrated that docetaxel was effective in patients with cutaneous AS.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Hemangiosarcoma / drug therapy. Skin Neoplasms / drug therapy. Taxoids / therapeutic use

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  • [Copyright] (c) 2007 American Cancer Society.
  • (PMID = 17582627.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Taxoids; 15H5577CQD / docetaxel
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61. Hanasono MM, Osborne MP, Dielubanza EJ, Peters SB, Gayle LB: Radiation-induced angiosarcoma after mastectomy and TRAM flap breast reconstruction. Ann Plast Surg; 2005 Feb;54(2):211-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Radiation-induced angiosarcoma after mastectomy and TRAM flap breast reconstruction.
  • Radiation-induced angiosarcoma of the breast is being reported with increasing frequency as a result of the increased use of radiation therapy in conjunction with breast conservation surgery.
  • The authors present a case of angiosarcoma occurring in a patient 6 years after undergoing mastectomy for invasive duct carcinoma with immediate transverse rectus abdominis musculocutaneous flap reconstruction followed by postoperative radiation therapy.
  • The diagnosis of angiosarcoma was made by skin biopsy performed by the patient's reconstructive surgeon on routine follow-up examination.
  • This is the first reported case of postradiation angiosarcoma occurring in a postmastectomy breast reconstructed with autogenous tissue and it is unusual in that the cancer invaded the musculocutaneous flap.
  • Diagnosis and management recommendations for radiation-induced angiosarcoma are discussed.
  • [MeSH-major] Breast Neoplasms / surgery. Carcinoma, Ductal, Breast / surgery. Hemangiosarcoma / etiology. Mastectomy, Modified Radical. Neoplasms, Radiation-Induced / surgery

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  • (PMID = 15655476.001).
  • [ISSN] 0148-7043
  • [Journal-full-title] Annals of plastic surgery
  • [ISO-abbreviation] Ann Plast Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ki-67 Antigen
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62. Di Tommaso L, Rosai J: The capillary lobule: a deceptively benign feature of post-radiation angiosarcoma of the skin: report of three cases. Am J Dermatopathol; 2005 Aug;27(4):301-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The capillary lobule: a deceptively benign feature of post-radiation angiosarcoma of the skin: report of three cases.
  • Three cases are presented of a proliferative vascular lesion of the skin developing in the chest wall of women who had received radiation therapy for breast carcinoma.
  • All 3 lesions were characterized microscopically by the presence of the so-called capillary lobule, a formation generally regarded as a sign of benignancy but that in this setting proved to be a forerunner or indicator of angiosarcoma (malignant hemangioendothelioma).
  • Therefore, the detection of capillary lobules in irradiated skin ought to be regarded with great suspicion, and other morphologic signs suggestive of angiosarcoma should be sought in the specimen.
  • [MeSH-major] Hemangiosarcoma / pathology. Neoplasms, Radiation-Induced / pathology. Neoplasms, Second Primary / pathology. Skin Neoplasms / pathology

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  • [CommentIn] Am J Dermatopathol. 2006 Aug;28(4):376 [16871048.001]
  • (PMID = 16121049.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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63. Boswell JS, Davis MD: Violaceous plaque on the forehead clinically resembling angiosarcoma: cutaneous metastasis in a patient with prostatic adenocarcinoma. J Am Acad Dermatol; 2005 Oct;53(4):744-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Violaceous plaque on the forehead clinically resembling angiosarcoma: cutaneous metastasis in a patient with prostatic adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / secondary. Hemangiosarcoma / diagnosis. Prostatic Neoplasms / pathology. Skin Neoplasms / secondary

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  • (PMID = 16198815.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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64. Weaver J, Billings SD: Postradiation cutaneous vascular tumors of the breast: a review. Semin Diagn Pathol; 2009 Aug;26(3):141-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Postradiation cutaneous vascular tumors of the breast: a review.
  • (1) postradiation cutaneous angiosarcoma, malignant vascular neoplasms with significant morbidity and mortality; and (2) atypical vascular lesions (AVL), vascular tumors that reportedly behave in a benign manner.
  • Although first described separately 15 years ago, the relationship between postradiation cutaneous angiosarcoma and AVL remains controversial.
  • It appears that, in at least some cases, angiosarcoma can arise in the context of AVL, suggesting that these lesions are part of a spectrum of the same disease process.
  • Herein, we will discuss the evolution of this topic while reviewing the various clinical, histopathologic, and prognostic characteristics of postradiation cutaneous angiosarcoma and AVL.
  • [MeSH-major] Breast Neoplasms / radiotherapy. Hemangiosarcoma / pathology. Neoplasms, Radiation-Induced / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Female. Humans. Middle Aged. Neoplasm Recurrence, Local. Prognosis

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  • (PMID = 20043513.001).
  • [ISSN] 0740-2570
  • [Journal-full-title] Seminars in diagnostic pathology
  • [ISO-abbreviation] Semin Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 21
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65. Thong PS, Olivo M, Kho KW, Bhuvaneswari R, Chin WW, Ong KW, Soo KC: Immune response against angiosarcoma following lower fluence rate clinical photodynamic therapy. J Environ Pathol Toxicol Oncol; 2008;27(1):35-42
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  • [Title] Immune response against angiosarcoma following lower fluence rate clinical photodynamic therapy.
  • In this clinical case report, we describe the response of angiosarcoma to PDT carried out using different fluence rates and drug and light doses.
  • A patient with recurrent multifocal angiosarcoma of the head and neck was recruited for PDT.
  • [MeSH-major] Head and Neck Neoplasms / drug therapy. Hemangiosarcoma / drug therapy. Neoplasm Recurrence, Local. Photochemotherapy / methods. Skin Neoplasms / drug therapy

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  • (PMID = 18551894.001).
  • [ISSN] 0731-8898
  • [Journal-full-title] Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer
  • [ISO-abbreviation] J. Environ. Pathol. Toxicol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Photolon; 0 / Photosensitizing Agents; 0 / Protoporphyrins; 9003-39-8 / Povidone
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66. Sparsa A, Liozon E, Wechsler J, Soria P, Delage-Core M, Loustaud V, Bedane C, Bonnetblanc JM, Vidal E: Aortic angiosarcoma clinically mimicking polyarteritis nodosa. Scand J Rheumatol; 2006 May-Jun;35(3):237-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Aortic angiosarcoma clinically mimicking polyarteritis nodosa.
  • We report two patients in whom angiosarcoma of the aorta (ASA) with distal emboli and skin metastases was initially clinically misdiagnosed as polyarteritis nodosa (PAN).
  • Both presented with features highly suggestive of systemic necrotizing vasculitis, including constitutional symptoms, orchitis (in one), leg pain with sensory neuropathy, livedo, focal areas of skin necrosis, painful cutaneous nodules demonstrating vasculitis or inconspicuous changes on biopsy, raised acute phase reactants, and transient improvement with systemic corticosteroids.
  • Repeated skin biopsies revealed an atypical endovascular cell proliferation with strong reactivity for factor VIII.
  • [MeSH-major] Aortic Diseases / diagnosis. Hemangiosarcoma / diagnosis. Polyarteritis Nodosa / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Male. Middle Aged. Neoplastic Cells, Circulating. Skin Neoplasms / secondary

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  • (PMID = 16766373.001).
  • [ISSN] 0300-9742
  • [Journal-full-title] Scandinavian journal of rheumatology
  • [ISO-abbreviation] Scand. J. Rheumatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Norway
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67. Lahat G, Dhuka AR, Lahat S, Smith KD, Pollock RE, Hunt KK, Ravi V, Lazar AJ, Lev D: Outcome of locally recurrent and metastatic angiosarcoma. Ann Surg Oncol; 2009 Sep;16(9):2502-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Outcome of locally recurrent and metastatic angiosarcoma.
  • BACKGROUND: Angiosarcoma (AS) is a rare soft tissue sarcoma with an enhanced propensity for local and systemic failure.
  • RESULTS: Forty-four patients were treated for locally recurrent AS; the majority (59%) were <or=5 cm; the most common sites were skin (48%) and breast (32%).
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Hemangiosarcoma / secondary. Neoplasm Recurrence, Local / pathology. Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Combined Modality Therapy. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. Prognosis. Radiotherapy Dosage. Retrospective Studies. Survival Rate. Treatment Outcome. Young Adult

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  • (PMID = 19551444.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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68. Tsolakis I, Lampropoulos G, Zolota V, Papadoulas S, Christeas N: Aortic angiosarcoma with cutaneous metastases. Vascular; 2009 May-Jun;17(3):176-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Aortic angiosarcoma with cutaneous metastases.
  • The diagnosis of aortic angiosarcoma is usually confirmed by postoperative histopathologic examination or postmortem study.
  • We present a case of primary aortic angiosarcoma presenting with intermittent claudication and radiologic findings of aortoiliac atherosclerotic disease treated initially with stenting; lower extremity embolic skin metastases developed during follow-up that prompted resection of the aortic bifurcation and restoration of the arterial continuity with a bypass.
  • [MeSH-major] Aortic Diseases / diagnostic imaging. Foot Diseases / etiology. Hemangiosarcoma / diagnostic imaging. Skin Neoplasms / secondary

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  • (PMID = 19476753.001).
  • [ISSN] 1708-5381
  • [Journal-full-title] Vascular
  • [ISO-abbreviation] Vascular
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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69. Arlett CF, Plowman PN, Rogers PB, Parris CN, Abbaszadeh F, Green MH, McMillan TJ, Bush C, Foray N, Lehmann AR: Clinical and cellular ionizing radiation sensitivity in a patient with xeroderma pigmentosum. Br J Radiol; 2006 Jun;79(942):510-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The patient was unusual in presenting with an angiosarcoma of the scalp, treated by surgical excision and radiotherapy.
  • [MeSH-major] Head and Neck Neoplasms / radiotherapy. Hemangiosarcoma / radiotherapy. Radiation Tolerance / genetics. Scalp. Skin Neoplasms / radiotherapy. Xeroderma Pigmentosum / complications

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  • (PMID = 16714754.001).
  • [ISSN] 0007-1285
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 156533-34-5 / XPC protein, human
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70. Mallick A, Jain S, Proctor A, Pandey R: Angiosarcoma around a revision total hip arthroplasty and review of literature. J Arthroplasty; 2009 Feb;24(2):323.e17-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma around a revision total hip arthroplasty and review of literature.
  • We report a case of angiosarcoma at the site of a revision total hip arthroplasty.
  • We found only 3 previous reports on angiosarcoma associated with hip arthroplasty in English literature.
  • Association between malignant tumor and hip arthroplasty deserves attention because this surgical procedure is so common that possible risk of a neoplasm should be quantified.
  • Sarcoma is rare, and its possible causation by retained foreign body material has been reported only as single cases.
  • [MeSH-major] Arthroplasty, Replacement, Hip / adverse effects. Hemangiosarcoma / diagnosis. Hip Prosthesis / adverse effects. Skin Neoplasms / diagnosis. Soft Tissue Neoplasms / diagnosis

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  • (PMID = 18617362.001).
  • [ISSN] 1532-8406
  • [Journal-full-title] The Journal of arthroplasty
  • [ISO-abbreviation] J Arthroplasty
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Metals
  • [Number-of-references] 25
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71. Devillers C, Vanhooteghem O, de la Brassinne M: [Lymphedema and cutaneous diseases]. Rev Med Suisse; 2007 Dec 5;3(136):2802-5
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  • [Title] [Lymphedema and cutaneous diseases].
  • Clinical changes of skin can occur.
  • The major cutaneous complications are infections, dysimmune diseases and neoplasms; the most serious is angiosarcoma.
  • [MeSH-major] Lymphedema / complications. Skin Diseases / etiology
  • [MeSH-minor] Dermatomycoses / etiology. Erysipelas / etiology. Hemangiosarcoma. Humans. Intertrigo / microbiology. Pemphigoid, Bullous / etiology. Skin Neoplasms / etiology. Sweet Syndrome / etiology

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  • (PMID = 18183816.001).
  • [ISSN] 1660-9379
  • [Journal-full-title] Revue médicale suisse
  • [ISO-abbreviation] Rev Med Suisse
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Switzerland
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72. Pfeiffer DF, Bode-Lesniewska B: Fine needle aspiration biopsy diagnosis of angiosarcoma after breast-conserving therapy for carcinoma supported by use of a cell block and immunohistochemistry. Acta Cytol; 2006 Sep-Oct;50(5):553-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fine needle aspiration biopsy diagnosis of angiosarcoma after breast-conserving therapy for carcinoma supported by use of a cell block and immunohistochemistry.
  • BACKGROUND: Angiosarcoma is a rare malignant soft tissue tumor occurring at various sites as either a primary or secondary event.
  • Primary angiosarcoma of the breast is an unusual tumor, counting for 1 in 1700-2,000 primary malignant tumors of this organ.
  • An increasing number of secondary angiosarcomas involving skin and breast.
  • CASE: Angiosarcoma arose 6 years after breast-conserving therapy for invasive carcinoma in a 69-year-old woman.
  • Fine needle aspiration of several small, reddish, intradermal nodules over the treated area revealed malignant cells with an endothelial immunophenotype in the cel block, yielding the diagnosis of angiosarcoma, subsequently confired in a mastectomy speciman.
  • CONCLUSION: Fine needle aspiration, supported by ancillary techniques, such as cell block and immunohistochemistry, allows the cytologic diagnosis of an angiosarcoma and differentiates it from a carcinoma recurrence.
  • [MeSH-major] Breast / pathology. Breast Neoplasms / diagnosis. Carcinoma, Ductal, Breast / diagnosis. Hemangiosarcoma / diagnosis. Neoplasms, Second Primary / diagnosis. Radiotherapy / adverse effects
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Biomarkers, Tumor / metabolism. Biopsy, Fine-Needle. Cell Nucleus / pathology. Diagnosis, Differential. Epithelial Cells / pathology. Female. Humans. Immunohistochemistry / methods. Neoplasm Recurrence, Local / diagnosis

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  • (PMID = 17017445.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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73. Schlauder SM, Bowers J, Morgan MB: A surreptitious sinister sarcoma. Am J Dermatopathol; 2007 Jun;29(3):311-2; discussion 313
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A surreptitious sinister sarcoma.
  • Angiosarcoma is an exceedingly rare endothelial-derived sarcoma that, when seen, usually presents as an expanding bruise-like patch or violaceous papule/nodule on the head of an elderly patient.
  • Herein, we present the histologic features of an unusual case that defied initial diagnosis.
  • [MeSH-major] Hemangiosarcoma / pathology. Skin Neoplasms / pathology

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  • (PMID = 17519636.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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74. Lee BA, Wanat KA, Eisen AZ: Cutaneous angiosarcoma of the knee: a case report and review of the literature. Cutis; 2009 Feb;83(2):91-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cutaneous angiosarcoma of the knee: a case report and review of the literature.
  • Cutaneous angiosarcoma is a rare, malignant, vascular tumor that usually occurs in the scalp and face region of elderly white men.
  • We report an unusual case of angiosarcoma occurring on the knee of a 70-year-old white woman with a strong family history of malignant melanoma in the absence of any known predisposing features.
  • [MeSH-major] Hemangiosarcoma / diagnosis. Knee Joint / pathology. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans

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  • (PMID = 19326694.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 19
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75. Wong J, Huerter C: Clinicopathologic challenge. Angiosarcoma of the scalp. Int J Dermatol; 2008 Sep;47(9):881-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinicopathologic challenge. Angiosarcoma of the scalp.
  • [MeSH-major] Hemangiosarcoma / pathology. Scalp. Skin Neoplasms / pathology
  • [MeSH-minor] Aged, 80 and over. Biopsy, Needle. Early Diagnosis. Female. Humans. Immunohistochemistry. Neoplasm Staging. Prognosis. Risk Assessment

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  • (PMID = 18937648.001).
  • [ISSN] 1365-4632
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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76. Park JW, Serafica-Karen C, Das K: Fine-needle aspiration of metastatic radiation-induced cutaneous epithelioid angiosarcoma of the breast to the liver: A diagnostic dilemma. Diagn Cytopathol; 2010 Oct;38(10):768-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fine-needle aspiration of metastatic radiation-induced cutaneous epithelioid angiosarcoma of the breast to the liver: A diagnostic dilemma.
  • Radiation therapy is a significant risk factor for the development of angiosarcoma.
  • With the increase in breast conservation treatment, the incidence of cutaneous radiation-induced angiosarcoma of the breast is rising.
  • If the angiosarcoma demonstrates epithelioid features, the tumor cells may present a diagnostic dilemma on fine-needle aspiration cytology.
  • We present a case of metastatic radiation-induced cutaneous epithelioid angiosarcoma of the breast to the liver and a review of the literature.
  • [MeSH-minor] Breast Neoplasms / metabolism. Breast Neoplasms / secondary. Carcinoma in Situ / radiotherapy. Carcinoma in Situ / surgery. Carcinoma, Ductal, Breast / radiotherapy. Carcinoma, Ductal, Breast / surgery. Cytodiagnosis. Diagnosis, Differential. Female. Hemangiosarcoma / metabolism. Hemangiosarcoma / secondary. Humans. Immunohistochemistry. Mastectomy, Segmental. Middle Aged. Radiotherapy, Adjuvant / adverse effects. Skin Neoplasms / metabolism. Skin Neoplasms / pathology

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  • [Copyright] © 2010 Wiley-Liss, Inc.
  • (PMID = 20187111.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] Angiosarcoma of the breast
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77. Rajinikanth J, Gaikwad P, Raj JP, Tirkey AJ, Muthusami JC: Angiosarcoma of the scalp. Otolaryngol Head Neck Surg; 2008 Feb;138(2):255-6
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  • [Title] Angiosarcoma of the scalp.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Hemangiosarcoma / pathology. Scalp. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Biopsy. Combined Modality Therapy / methods. Diagnosis, Differential. Humans. Male

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  • (PMID = 18241726.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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78. Constantinou C, Sheldon D: Papillary endothelial hyperplasia of the adrenal gland: report of a case and review of the literature. Am Surg; 2008 Sep;74(9):813-6
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  • Papillary endothelial hyperplasia (PEH) is a benign vascular proliferative process most frequently seen in the skin and integument, but may involve any of the visceral organs.
  • Pathologic differentiation from angiosarcoma can be a difficult task requiring evaluation by an experienced pathologist.

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  • (PMID = 18807668.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 27
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79. Kunkel T, Mylonas I, Mayr D, Friese K, Sommer HL: Recurrence of secondary angiosarcoma in a patient with post-radiated breast for breast cancer. Arch Gynecol Obstet; 2008 Nov;278(5):497-501
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  • [Title] Recurrence of secondary angiosarcoma in a patient with post-radiated breast for breast cancer.
  • INTRODUCTION: Angiosarcoma of the breast is a rare finding.
  • Two different subtypes of angiosarcomas have been described: (a) the Stewart-Treves syndrome and (b) the cutaneous post-radiation angiosarcoma.
  • We report a case where both types of angiosarcoma occurred.
  • CASE REPORT: At first, an angiosarcoma affecting parenchyma of the breast was observed after radiotherapy following breast conserving therapy and a history of lymphoedema of the radiated area.
  • Additionally, a subsequent local recurrence of the angiosarcoma of the skin after mastectomy and complete resection of the primary angiosarcoma was diagnosed.
  • Patients should be pointed to this possible complication of radiotherapy and transferred to seek medical advice immediately in case of skin lesion in the irradiated area: even many years after radiotherapy.
  • Additionally, every oncologist should be aware of this rare complication as quick diagnosis and prompt surgical treatment is indispensable due to the aggressive entity of angiosarcoma.
  • [MeSH-major] Breast Neoplasms / therapy. Hemangiosarcoma / therapy. Neoplasm Recurrence, Local / therapy. Skin Neoplasms / therapy

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  • (PMID = 18305948.001).
  • [ISSN] 0932-0067
  • [Journal-full-title] Archives of gynecology and obstetrics
  • [ISO-abbreviation] Arch. Gynecol. Obstet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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80. Salameire D, Templier I, Charles J, Pinel N, Morand P, Leccia MT, Lantuejoul S: An "anaplastic" Kaposi's sarcoma mimicking a Stewart-Treves syndrome. A case report and a review of literature. Am J Dermatopathol; 2008 Jun;30(3):265-8
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  • [Title] An "anaplastic" Kaposi's sarcoma mimicking a Stewart-Treves syndrome. A case report and a review of literature.
  • Cutaneous angiosarcoma (AGS) developing in a lymphedematous arm, after lymphadenectomy in the context of breast cancer, is the definition of the classical Stewart-Treves syndrome.
  • Like AGS, many tumors such as Kaposi's sarcoma (KS) could develop in chronic lymphedema.
  • The final diagnosis was an "anaplastic" KS mimicking a Stewart-Treves syndrome.
  • "Anaplastic" KS is a rare histological form of nodular KS, which mimics a cutaneous AGS but classically expresses herpes human virus 8.
  • [MeSH-major] Hemangiosarcoma / diagnosis. Lymphangiosarcoma / diagnosis. Lymphedema / pathology. Sarcoma, Kaposi / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. DNA, Neoplasm / analysis. Diagnosis, Differential. Female. Herpesvirus 8, Human / isolation & purification. Humans. Middle Aged. Syndrome. Viral Proteins / metabolism

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  • (PMID = 18496429.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / Viral Proteins; 0 / assembly protein, Human herpesvirus 8
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81. Lucas DR: Angiosarcoma, radiation-associated angiosarcoma, and atypical vascular lesion. Arch Pathol Lab Med; 2009 Nov;133(11):1804-9
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  • [Title] Angiosarcoma, radiation-associated angiosarcoma, and atypical vascular lesion.
  • Angiosarcoma, one of the least common sarcomas, has become increasingly important because of its association with radiation therapy, especially for breast cancer.
  • Most are sporadic, presenting as cutaneous tumors in the scalp/face of elderly patients.
  • However, angiosarcoma has a wide anatomic distribution including soft tissue, visceral organ, and osseous locations.
  • Radiation-associated angiosarcoma typically presents as a cutaneous tumor several years posttherapy.
  • The latency for radiation-associated mammary angiosarcoma is relatively short, sometimes less than 3 years.
  • Atypical vascular lesion refers to a small, usually lymphatic-type vascular proliferation in radiated skin.
  • Although most atypical vascular lesions pursue a benign course, they recur and very rarely progress to angiosarcoma.
  • Distinguishing this lesion from well-differentiated angiosarcoma in a biopsy can be challenging, especially because areas indistinguishable from atypical vascular lesion are found adjacent to angiosarcoma.
  • [MeSH-major] Hemangioma / pathology. Hemangiosarcoma / pathology. Neoplasms, Radiation-Induced / pathology. Skin Neoplasms / pathology. Vascular Diseases / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Breast Neoplasms / radiotherapy. Female. Humans. Skin / blood supply

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  • (PMID = 19886715.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 12
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82. Grewal JS, Daniel AR, Carson EJ, Catanzaro AT, Shehab TM, Tworek JA: Rapidly progressive metastatic multicentric epithelioid angiosarcoma of the small bowel: a case report and a review of literature. Int J Colorectal Dis; 2008 Aug;23(8):745-56
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  • [Title] Rapidly progressive metastatic multicentric epithelioid angiosarcoma of the small bowel: a case report and a review of literature.
  • BACKGROUND: Angiosarcoma is a rare high-grade neoplasm that frequently involves the skin and subcutaneous tissue.
  • Rarely, angiosarcoma can occur in the gastrointestinal tract where it frequently exhibits multicentric epithelioid morphology.
  • DESIGN: We report a case of multicentric epithelioid angiosarcoma (EAS) of the small intestine in a 73-year-old male patient who presented with weakness and melena, and was found to have bleeding lesions in the small intestine on upper gastrointestinal endoscopy.
  • In addition to this case, we extensively reviewed the clinical and pathological features of previously reported cases of angiosarcoma of the small intestine in the English literature since 1970.
  • He died within 4 months of the diagnosis.
  • CONCLUSIONS: Angiosarcoma, especially of the deep tissues and the gastrointestinal tract, is very aggressive and rapidly metastatic.
  • The survival rate in these patients is extremely poor, and most patients die within 6 months to 1 year of the diagnosis.
  • [MeSH-major] Hemangiosarcoma / pathology. Hemangiosarcoma / secondary. Intestinal Neoplasms / pathology. Intestine, Small / pathology

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  • (PMID = 18080128.001).
  • [ISSN] 0179-1958
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 59
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83. Kasper DA, Smetanick MT, Ermolovich T: Angiosarcoma clinically resembling morpheaform basal cell carcinoma. Dermatol Surg; 2008 Oct;34(10):1407-10
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  • [Title] Angiosarcoma clinically resembling morpheaform basal cell carcinoma.
  • [MeSH-major] Carcinoma, Basal Cell / diagnosis. Hemangiosarcoma / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. Face. Female. Humans. Skin Ulcer / diagnosis

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  • (PMID = 18637812.001).
  • [ISSN] 1524-4725
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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84. Vasanawala MS, Wang Y, Quon A, Gambhir SS: F-18 fluorodeoxyglucose PET/CT as an imaging tool for staging and restaging cutaneous angiosarcoma of the scalp. Clin Nucl Med; 2006 Sep;31(9):534-7
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  • [Title] F-18 fluorodeoxyglucose PET/CT as an imaging tool for staging and restaging cutaneous angiosarcoma of the scalp.
  • Cutaneous angiosarcoma of the scalp is a rare highly aggressive malignant tumor that typically afflicts elderly patients and commonly presents with extensive local spread and distant metastasis.
  • Distant metastases favor lung, liver, lymph nodes, and skin.
  • We report the case of a 70-year-old man diagnosed with multifocal angiosarcoma of the scalp.
  • PET/CT imaging with F-18 2-fluoro-2-deoxyglucose (F-18 FDG) not only showed avid FDG uptake by an angiosarcoma (SUVmax = 10.7), but also simultaneously showed local extension of multifocal lesions with periosteal involvement and excluded metastatic abdominal nodal disease.
  • Evaluation of more cases of this subset of soft tissue sarcoma with FDG PET/CT may suggest a possible role in not only staging angiosarcomas to determine the extent of local as well as distant disease, but also to potentially help determine response to therapy and early recognition of local or distant recurrence.
  • [MeSH-major] Fluorodeoxyglucose F18. Hemangiosarcoma / diagnosis. Hemangiosarcoma / radionuclide imaging. Neoplasm Staging / methods. Positron-Emission Tomography / methods. Radiopharmaceuticals. Scalp / pathology. Skin Neoplasms / diagnosis. Skin Neoplasms / radionuclide imaging. Tomography, X-Ray Computed / methods

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  • (PMID = 16921276.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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85. Chen SY, Takeuchi S, Urabe K, Hayashida S, Kido M, Tomoeda H, Uchi H, Dainichi T, Takahara M, Shibata S, Tu YT, Furue M, Moroi Y: Overexpression of phosphorylated-ATF2 and STAT3 in cutaneous angiosarcoma and pyogenic granuloma. J Cutan Pathol; 2008 Aug;35(8):722-30
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  • [Title] Overexpression of phosphorylated-ATF2 and STAT3 in cutaneous angiosarcoma and pyogenic granuloma.
  • BACKGROUND: Activating transcription factor-2/Activator protein-1 (AP-1), Signal transducer and activator of transcription-3 and p53 are important regulators of cellular proliferation, apoptosis, differentiation in the pathogenesis of many human tumors, but the expression of phosphorylated (p)-activating transcription factor-2 (p-ATF2), phosphorylated (p)-signal transducer and activator of transcription-3 (p-STAT3) and p53 family (p63 and p73) has not been investigated in cutaneous angiosarcoma (CAS) and pyogenic granuloma (PG) so far.
  • OBJECTIVES: To investigate the expression of p-ATF2, p-STAT3 and p53 and its family in cutaneous vascular tumors (CAS and PG).
  • The p-ATF2-, p-STAT3- and p53 expression (% positive cells) in CAS and PG were significantly higher than in normal dermal vessels, but none of these transcription factors distinguished malignant (CAS)- from benign (PG) vascular tumor.
  • CONCLUSIONS: The present study suggests that overexpression of p-ATF2, p-STAT3 and possibly p53, but not p63 or p73, may contribute to the tumorigenesis of cutaneous vascular tumors.
  • [MeSH-major] Activating Transcription Factor 2 / biosynthesis. Gene Expression Regulation, Neoplastic. Granuloma, Pyogenic / metabolism. Hemangiosarcoma / metabolism. STAT3 Transcription Factor / biosynthesis. Skin Neoplasms / metabolism. Tumor Suppressor Protein p53 / biosynthesis


86. Chiu LS, Wong KH, Lam WY, Luk NM, Lo KK: Angiosarcoma of the scrotum after treatment of cancer of the rectum. Clin Exp Dermatol; 2006 Sep;31(5):706-7
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  • [Title] Angiosarcoma of the scrotum after treatment of cancer of the rectum.
  • [MeSH-major] Hemangiosarcoma / etiology. Rectal Neoplasms / therapy. Scrotum. Skin Neoplasms / etiology. Testicular Neoplasms / etiology

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  • (PMID = 16901314.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
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87. Bhutoria B, Konar A, Chakrabarti S, Das S: Retiform hemangioendothelioma with lymph node metastasis: a rare entity. Indian J Dermatol Venereol Leprol; 2009 Jan-Feb;75(1):60-2
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  • Retiform hemangioendothelioma (RH) is a rare, recently described, unique kind of low grade angiosarcoma.
  • The tumor chiefly originates from the skin and subcutaneous tissue and has a tendency to recur locally.
  • [MeSH-major] Hemangioendothelioma / diagnosis. Hemangioendothelioma / pathology. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / pathology

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  • (PMID = 19172034.001).
  • [ISSN] 0973-3922
  • [Journal-full-title] Indian journal of dermatology, venereology and leprology
  • [ISO-abbreviation] Indian J Dermatol Venereol Leprol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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88. de Giorgi V, Santi R, Grazzini M, Papi F, Gori A, Rossari S, Massi D, Lotti T: Synchronous angiosarcoma, melanoma and morphea of the breast skin 14 years after radiotherapy for mammary carcinoma. Acta Derm Venereol; 2010 May;90(3):283-6
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  • [Title] Synchronous angiosarcoma, melanoma and morphea of the breast skin 14 years after radiotherapy for mammary carcinoma.
  • We describe here the case of a 68-year-old woman who developed synchronous cutaneous angiosarcoma, melanoma and morphea of the breast skin and the local area, 14 years after radiotherapy for breast carcinoma.
  • Given the risk of post-radiation secondary primaries in breast cancer patients, long-term surveillance is necessary, with particular attention being paid to skin changes in the irradiation field.
  • Radiation-induced morphea is a rare complication in which immunological abnormalities may stimulate malignant transformation.
  • [MeSH-major] Breast Neoplasms / radiotherapy. Carcinoma / radiotherapy. Hemangiosarcoma / etiology. Melanoma / etiology. Neoplasms, Radiation-Induced / etiology. Neoplasms, Second Primary / etiology. Scleroderma, Localized / etiology. Skin Neoplasms / etiology
  • [MeSH-minor] Aged. Female. Humans. Radiotherapy / adverse effects. Skin / pathology. Skin / radiation effects. Time Factors


89. Buschmann A, Lehnhardt M, Toman N, Preiler P, Salakdeh MS, Muehlberger T: Surgical treatment of angiosarcoma of the scalp: less is more. Ann Plast Surg; 2008 Oct;61(4):399-403
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  • [Title] Surgical treatment of angiosarcoma of the scalp: less is more.
  • In 19 patients, we performed a resection of the external table with the defect being covered immediately by a split skin graft.
  • In view of the difficult diagnosis, an often delayed therapy and the rapid formation of metastases, a time-saving procedure with a low rate of complications should be given preference over other reconstructive methods.
  • [MeSH-major] Head and Neck Neoplasms / surgery. Hemangiosarcoma / surgery. Reconstructive Surgical Procedures / methods. Scalp / surgery. Skin Neoplasms / surgery
  • [MeSH-minor] Aged. Aged, 80 and over. Chemotherapy, Adjuvant. Female. Humans. Length of Stay. Male. Neoplasm Recurrence, Local / radiotherapy. Neoplasm Recurrence, Local / surgery. Palliative Care. Radiotherapy, Adjuvant. Skin Transplantation. Wound Healing


90. Bacchi CE, Silva TR, Zambrano E, Plaza J, Suster S, Luzar B, Lamovec J, Pizzolitto S, Falconieri G: Epithelioid angiosarcoma of the skin: a study of 18 cases with emphasis on its clinicopathologic spectrum and unusual morphologic features. Am J Surg Pathol; 2010 Sep;34(9):1334-43
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  • [Title] Epithelioid angiosarcoma of the skin: a study of 18 cases with emphasis on its clinicopathologic spectrum and unusual morphologic features.
  • We report 18 cases of cutaneous angiosarcoma with predominant or exclusive epithelioid morphology.
  • In elderly patients scalp or facial lesions and cutaneous lesions arising within irradiated breast skin predominated.
  • Our data show that epithelioid cutaneous angiosarcoma may have a broad morphological spectrum, raising interpretive challenges on microscopy.
  • [MeSH-major] Epithelioid Cells / pathology. Hemangiosarcoma / pathology. Skin Neoplasms / pathology

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  • (PMID = 20697249.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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91. Glazebrook KN, Magut MJ, Reynolds C: Angiosarcoma of the breast. AJR Am J Roentgenol; 2008 Feb;190(2):533-8
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  • [Title] Angiosarcoma of the breast.
  • CONCLUSION: With the increasing use of breast conservation therapy for breast cancer, reports of postirradiation angiosarcoma have increased.
  • Both primary and secondary angiosarcomas may present with bruiselike skin discoloration, which may delay the diagnosis.
  • [MeSH-major] Breast Neoplasms / diagnosis. Diagnostic Imaging / methods. Hemangiosarcoma / diagnosis. Image Enhancement / methods

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  • (PMID = 18212243.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 18
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92. Jain M, Singh S, Agarwal K: Spindle cell neoplasm of skin: diagnostic dilemma. Indian J Pathol Microbiol; 2007 Oct;50(4):814-6
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  • [Title] Spindle cell neoplasm of skin: diagnostic dilemma.
  • Poorly differentiated, spindle cell malignancies, on sun damaged skin frequently pose a diagnostic challenge for pathologists.
  • The vast majority of these neoplasms ultimately are diagnosed as either atypical fibroxanthoma (AFX), spindle cell melanoma (SCM), and very rarely as spindle cell squamous cell carcinoma (SCSCC), leiomyosarcoma or angiosarcoma.
  • Light microscopic clues may suggest one of these neoplasms, but subtle and overlapping characteristics often render precise diagnosis impossible based on morphological features alone.
  • Immunohistochemistry therefore is necessary to firmly and accurately diagnose the majority of spindle cell malignancies on sun damaged skin.
  • [MeSH-major] Sarcoma / diagnosis. Sarcoma / pathology. Skin Neoplasms / diagnosis. Skin Neoplasms / pathology
  • [MeSH-minor] Aged, 80 and over. Carcinoma, Squamous Cell / pathology. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Keratins / analysis. Melanoma / pathology. S100 Proteins / analysis. Vimentin / analysis. Xanthomatosis / pathology

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  • (PMID = 18306566.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / S100 Proteins; 0 / Vimentin; 68238-35-7 / Keratins
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93. Kisseberth WC, Vail DM, Yaissle J, Jeglum KA, Couto CG, Ward H, Khanna C, Obradovich JE: Phase I clinical evaluation of carboplatin in tumor-bearing cats: a Veterinary Cooperative Oncology Group study. J Vet Intern Med; 2008 Jan-Feb;22(1):83-8
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  • There was 1 complete response (cutaneous hemangiosarcoma) and 6 partial responses (4 injection site sarcomas, 1 oral squamous cell carcinoma, 1 lymphoma).

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  • (PMID = 18289293.001).
  • [ISSN] 0891-6640
  • [Journal-full-title] Journal of veterinary internal medicine
  • [ISO-abbreviation] J. Vet. Intern. Med.
  • [Language] ENG
  • [Publication-type] Clinical Trial, Phase I; Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; AYI8EX34EU / Creatinine; BG3F62OND5 / Carboplatin
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94. Jowett AJ, Parvin SD: Angiosarcoma in an area of lipodermatosclerosis. Ann R Coll Surg Engl; 2008 Jul;90(5):W15-6
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  • [Title] Angiosarcoma in an area of lipodermatosclerosis.
  • An area within this broke down as a result of an angiosarcoma rather than the more probable: formation of a venous ulcer.
  • [MeSH-major] Hemangiosarcoma / etiology. Leg Ulcer / complications. Skin Neoplasms / etiology

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  • [Cites] J Surg Oncol. 2000 Mar;73(3):182-8 [10738275.001]
  • [Cites] CA Cancer J Clin. 1981 Sep-Oct;31(5):284-99 [6793218.001]
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  • (PMID = 18634723.001).
  • [ISSN] 1478-7083
  • [Journal-full-title] Annals of the Royal College of Surgeons of England
  • [ISO-abbreviation] Ann R Coll Surg Engl
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2645745
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95. Selim A, Khachemoune A, Lockshin NA: Angiosarcoma: a case report and review of the literature. Cutis; 2005 Nov;76(5):313-7
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  • [Title] Angiosarcoma: a case report and review of the literature.
  • Angiosarcoma is an aggressive neoplasm that predominantly affects elderly patients.
  • [MeSH-major] Hemangiosarcoma / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. Humans. Male. Nose / pathology. Nose / surgery. Radiotherapy, Adjuvant

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  • (PMID = 16422466.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 28
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96. Gonzalez MJ, Koehler MM, Satter EK: Angiosarcoma of the scalp: a case report and review of current and novel therapeutic regimens. Dermatol Surg; 2009 Apr;35(4):679-84
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  • [Title] Angiosarcoma of the scalp: a case report and review of current and novel therapeutic regimens.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Head and Neck Neoplasms / therapy. Hemangiosarcoma / therapy. Neoplasm Recurrence, Local / therapy. Surgical Flaps
  • [MeSH-minor] Aged, 80 and over. Combined Modality Therapy. Humans. Male. Radiotherapy, Adjuvant. Scalp. Skin Transplantation

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  • (PMID = 19415795.001).
  • [ISSN] 1524-4725
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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97. Chen JL, Mok KT, Tseng HH, Wang BW, Liu SI, Chen CW: Duodenal angiosarcoma: an unusual cause of severe gastrointestinal bleeding. J Chin Med Assoc; 2007 Aug;70(8):352-5
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  • [Title] Duodenal angiosarcoma: an unusual cause of severe gastrointestinal bleeding.
  • Angiosarcoma is a rare soft-tissue neoplasm that occurs most often in the skin and the subcutaneous tissues but very rarely in the gastrointestinal tract.
  • We report a case of primary intestinal angiosarcoma with severe gastrointestinal bleeding.
  • The pathology was consistent with angiosarcoma of the duodenum.
  • [MeSH-major] Duodenal Neoplasms / complications. Gastrointestinal Hemorrhage / etiology. Hemangiosarcoma / complications

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  • (PMID = 17698438.001).
  • [ISSN] 1726-4901
  • [Journal-full-title] Journal of the Chinese Medical Association : JCMA
  • [ISO-abbreviation] J Chin Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
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98. Brenn T, Fletcher CD: Postradiation vascular proliferations: an increasing problem. Histopathology; 2006 Jan;48(1):106-14
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  • The occurrence of cutaneous vascular lesions is a rare but well-documented complication of radiation treatment and may be associated with significant morbidity as well as mortality.
  • The spectrum of postradiation vascular lesions is wide and ranges from atypical vascular lesions with reportedly benign clinical behaviour to frank cutaneous angiosarcoma.
  • [MeSH-major] Hemangiosarcoma / pathology. Neoplasms, Radiation-Induced / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Skin / blood supply. Skin / pathology. Skin / radiation effects

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  • (PMID = 16359542.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 80
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99. Asgari MM, Cockerell CJ, Weitzul S: The head-tilt maneuver: a clinical aid in recognizing head and neck angiosarcomas. Arch Dermatol; 2007 Jan;143(1):75-7
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  • BACKGROUND: Cutaneous angiosarcoma is a rare, life-threatening tumor that is often initially misdiagnosed.
  • This delay in diagnosis can affect tumor growth, metastatic potential, and prognosis.
  • [MeSH-major] Head Movements. Head and Neck Neoplasms / diagnosis. Hemangiosarcoma / diagnosis. Skin / pathology
  • [MeSH-minor] Diagnosis, Differential. Face. Head-Down Tilt. Humans. Male. Torsion Abnormality

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  • (PMID = 17224545.001).
  • [ISSN] 0003-987X
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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100. Kaminaka C, Yamamoto Y, Yonei N, Furukawa F: Phenol application to angiosarcomas: implications and histologic studies. Int J Dermatol; 2009 May;48(5):470-5
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  • BACKGROUND: Cutaneous angiosarcoma (AS) is an aggressive endothelial sarcoma that arises in elderly people.
  • AIMS: To evaluate the efficacy of phenol application for the treatment of AS, and to examine the histologic changes in three cases of cutaneous AS with phenol application.
  • METHODS: After phenol application, biopsy specimens were collected from three patients with cutaneous AS.
  • Paraffin-embedded sections of the skin specimens were then stained with hematoxylin and eosin.
  • [MeSH-major] Hemangiosarcoma / drug therapy. Hemangiosarcoma / pathology. Phenol / therapeutic use. Sclerosing Solutions / therapeutic use. Skin Neoplasms / drug therapy. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Apoptosis / drug effects. Biopsy. Female. Humans. In Situ Nick-End Labeling. Skin / pathology

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  • (PMID = 19416375.001).
  • [ISSN] 1365-4632
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Sclerosing Solutions; 339NCG44TV / Phenol
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