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1. Berretta M, Rupolo M, Buonadonna A, Canzonieri V, Brollo A, Morra A, Berretta S, Bearz A, Tirelli U, Frustaci S: Metastatic angiosarcoma of the kidney: a case report with treatment approach and review of the literature. J Chemother; 2006 Apr;18(2):221-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic angiosarcoma of the kidney: a case report with treatment approach and review of the literature.
  • Angiosarcomas are rare soft tissue malignancies.
  • We report the case of a 67-year-old man affected by a large angiosarcoma of the kidney.
  • [MeSH-major] Hemangiosarcoma / drug therapy. Hemangiosarcoma / surgery. Kidney Neoplasms / drug therapy. Kidney Neoplasms / surgery
  • [MeSH-minor] Aged. Anthracyclines / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Combined Modality Therapy. Fatal Outcome. Humans. Ifosfamide / administration & dosage. Liver Neoplasms / secondary. Lung Neoplasms / drug therapy. Lung Neoplasms / secondary. Male. Nephrectomy. Palliative Care. Peritoneal Neoplasms / drug therapy. Peritoneal Neoplasms / secondary. Splenic Neoplasms / drug therapy. Splenic Neoplasms / secondary. Treatment Outcome

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  • (PMID = 16736893.001).
  • [ISSN] 1120-009X
  • [Journal-full-title] Journal of chemotherapy (Florence, Italy)
  • [ISO-abbreviation] J Chemother
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Anthracyclines; UM20QQM95Y / Ifosfamide
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2. Arteche E, Ostiz S, de Miguel C: [Case 2. Diffuse hepatic angiosarcoma secondary to thorotrast deposit]. Radiologia; 2007 Jan-Feb;49(1):28; discussion 57
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  • [Title] [Case 2. Diffuse hepatic angiosarcoma secondary to thorotrast deposit].
  • [MeSH-major] Contrast Media / adverse effects. Hemangiosarcoma / chemically induced. Hemangiosarcoma / radiography. Liver Neoplasms / chemically induced. Liver Neoplasms / radiography. Thorium Dioxide / adverse effects

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  • (PMID = 17397617.001).
  • [ISSN] 0033-8338
  • [Journal-full-title] Radiología
  • [ISO-abbreviation] Radiologia
  • [Language] spa
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Carcinogens; 0 / Contrast Media; 9XA7X17UQC / Thorium Dioxide
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3. Hara T, Tsurumi H, Kasahara S, Ogawa K, Takada J, Imai K, Takai K, Kitagawa J, Kiyama S, Imai N, Oyama M, Takami T, Moriwaki H: Long-term survival of a patient with splenic angiosarcoma after resection, high-dose chemotherapy, and autologous peripheral blood stem cell transplantation. Intern Med; 2010;49(20):2253-7
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  • [Title] Long-term survival of a patient with splenic angiosarcoma after resection, high-dose chemotherapy, and autologous peripheral blood stem cell transplantation.
  • Histological examination was typical for angiosarcoma.
  • CT scan showed a hepatic tumor.
  • A fine-needle biopsy of the liver revealed the first relapse.
  • Despite hepatic lobectomy, radiofrequency ablations and administration of recombinant interleukin-2, she died from respiratory failure in 2009.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Hemangiosarcoma / therapy. Peripheral Blood Stem Cell Transplantation. Splenectomy. Splenic Neoplasms / therapy

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  • (PMID = 20962445.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Interleukin-3; 0 / Recombinant Proteins; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CHOP protocol
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4. Kopp HG, Kanz L, Hartmann JT: Complete remission of relapsing high-grade angiosarcoma with single-agent metronomic trofosfamide. Anticancer Drugs; 2006 Sep;17(8):997-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Complete remission of relapsing high-grade angiosarcoma with single-agent metronomic trofosfamide.
  • A limited repertoire of chemotherapeutics is available for the therapy of metastasizing angiosarcoma.
  • We report on a case from our clinic, in which a complete response with oral trofosfamide was achieved in a patient suffering from relapsed high-grade angiosarcoma metastasizing to the liver and lung.
  • [MeSH-major] Antineoplastic Agents, Alkylating / therapeutic use. Cyclophosphamide / analogs & derivatives. Hemangiosarcoma / drug therapy. Neoplasm Recurrence, Local / drug therapy

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  • (PMID = 16940811.001).
  • [ISSN] 0959-4973
  • [Journal-full-title] Anti-cancer drugs
  • [ISO-abbreviation] Anticancer Drugs
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 8N3DW7272P / Cyclophosphamide; H64JRU6GJ0 / trofosfamide
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5. Thompson WM, Levy AD, Aguilera NS, Gorospe L, Abbott RM: Angiosarcoma of the spleen: imaging characteristics in 12 patients. Radiology; 2005 Apr;235(1):106-15
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  • [Title] Angiosarcoma of the spleen: imaging characteristics in 12 patients.
  • PURPOSE: To retrospectively review clinical, pathologic, and imaging features of angiosarcoma of the spleen in 12 patients.
  • Records of 12 cases of proved angiosarcoma of the spleen were accessed from the files of the Armed Forces Institute of Pathology.
  • Presenting signs and symptoms were recorded, and the pathologist confirmed the diagnosis and determined gross and microscopic morphologic findings in each spleen.
  • Two patients had solitary hypervascular tumors and liver metastases.
  • Angiosarcoma of the spleen could be suggested in the majority of cases (83%) by using the imaging features of splenic mass with evidence of metastatic disease.
  • [MeSH-major] Hemangiosarcoma / diagnosis. Splenic Neoplasms / diagnosis

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  • [Copyright] (c) RSNA, 2005
  • (PMID = 15749977.001).
  • [ISSN] 0033-8419
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
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6. Arbiser JL, Bonner MY, Berrios RL: Hemangiomas, angiosarcomas, and vascular malformations represent the signaling abnormalities of pathogenic angiogenesis. Curr Mol Med; 2009 Nov;9(8):929-34
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  • [Title] Hemangiomas, angiosarcomas, and vascular malformations represent the signaling abnormalities of pathogenic angiogenesis.
  • Angiogenesis is a major factor in the development of benign, inflammatory, and malignant processes of the skin.
  • Furthermore, we have studied malignant vascular tumors, including hemangioendothelioma and angiosarcoma and have shown distinct signaling abnormalities in these tumors.
  • The incidence of these tumors is expected to rise due to environmental insults, such as radiation and lumpectomy for breast cancer, dietary and industrial carcinogens (hepatic angiosarcoma), and chronic ultraviolet exposure and potential Agent Orange exposure.
  • I hypothesize that hemangiomas, angiosarcomas, and vascular malformations represent the extremes of signaling abnormalities seen in pathogenic angiogenesis.
  • [MeSH-major] Hemangioma / blood supply. Hemangiosarcoma / blood supply. Neovascularization, Pathologic / pathology. Signal Transduction. Vascular Malformations / physiopathology


7. Puizina-Ivić N, Bezić J, Marasović D, Gotovac V, Carija A, Bozić M: Angiosarcoma arising in sclerodermatous skin. Acta Dermatovenerol Alp Pannonica Adriat; 2005 Mar;14(1):20-5
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  • [Title] Angiosarcoma arising in sclerodermatous skin.
  • We report a case of cutaneous angiosarcoma in a 77-year-old female patient with systemic sclerosis.
  • The pathohistological diagnosis was moderately differentiated angiosarcoma.
  • Despite a notable cutaneous improvement, the control check-up revealed the presence of metastases of the lung and liver.
  • This is the first report of cutaneous angiosarcoma occurring in sclerodermatous skin.
  • [MeSH-major] Facial Neoplasms / etiology. Hemangiosarcoma / etiology. Scleroderma, Systemic / complications. Scleroderma, Systemic / physiopathology. Skin Neoplasms / etiology
  • [MeSH-minor] Aged. Female. Humans. Liver Neoplasms / secondary. Lung Neoplasms / secondary

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  • (PMID = 15818442.001).
  • [ISSN] 1318-4458
  • [Journal-full-title] Acta dermatovenerologica Alpina, Pannonica, et Adriatica
  • [ISO-abbreviation] Acta Dermatovenerol Alp Pannonica Adriat
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Slovenia
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8. Sato KT, Lewandowski RJ, Mulcahy MF, Atassi B, Ryu RK, Gates VL, Nemcek AA Jr, Barakat O, Benson A 3rd, Mandal R, Talamonti M, Wong CY, Miller FH, Newman SB, Shaw JM, Thurston KG, Omary RA, Salem R: Unresectable chemorefractory liver metastases: radioembolization with 90Y microspheres--safety, efficacy, and survival. Radiology; 2008 May;247(2):507-15
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  • [Title] Unresectable chemorefractory liver metastases: radioembolization with 90Y microspheres--safety, efficacy, and survival.
  • PURPOSE: To prospectively evaluate the safety, efficacy, and survival of patients with chemorefractory liver metastases who have been treated with yttrium 90 ((90)Y) glass microspheres.
  • Primary sites (origins) included colon, breast, neuroendocrine, pancreas, lung, cholangiocarcinoma, melanoma, renal, esophageal, ovary, adenocarcinoma of unknown primary, lymphoma, gastric, duodenal, bladder, angiosarcoma, squamous cell carcinoma, thyroid, adrenal, and parotid.
  • Patients underwent evaluation of baseline and follow-up liver function and tumor markers and computed tomographic or magnetic resonance imaging.
  • CONCLUSION: (90)Y hepatic treatments are well tolerated with acceptable toxicities; tumor response and median survival are promising.
  • [MeSH-major] Liver Neoplasms / radiotherapy. Liver Neoplasms / secondary. Microspheres. Yttrium Radioisotopes / therapeutic use

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  • [Copyright] (c) RSNA, 2008.
  • (PMID = 18349311.001).
  • [ISSN] 1527-1315
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Databank-accession-numbers] ClinicalTrials.gov/ NCT00532740
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Yttrium Radioisotopes
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9. Jeong SW, Woo HY, You CR, Huh WH, Bae SH, Choi JY, Yoon SK, Jung CK, Jung ES: [A case of hepatic epithelioid hemangioendothelioma that caused extrahepatic metastases without intrahepatic recurrence after hepatic resection]. Korean J Hepatol; 2008 Dec;14(4):525-31
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  • [Title] [A case of hepatic epithelioid hemangioendothelioma that caused extrahepatic metastases without intrahepatic recurrence after hepatic resection].
  • Epithelioid hemangioendothelioma is a neoplasm of vascular origin with a low-to-intermediate malignant potential and is one of the rare sarcomas arising from the liver.
  • There is no generally accepted therapeutic strategy because of its rarity and the variable natural course between hemangioma and angiosarcoma.
  • We report a case of a 64-year old woman who underwent hepatic resection due to epithelioid hemangioendothelioma in the right lobe that progressed to extrahepatic metastases of the bone, pleura, and peritoneum 22 months later.
  • However, after resection there was no primary hepatic recurrence.
  • [MeSH-major] Hemangioendothelioma, Epithelioid / diagnosis. Hemangioendothelioma, Epithelioid / secondary. Liver Neoplasms / diagnosis
  • [MeSH-minor] Bone Neoplasms / diagnosis. Bone Neoplasms / pathology. Bone Neoplasms / secondary. Female. Hepatectomy. Humans. Lung Neoplasms / diagnosis. Lung Neoplasms / pathology. Lung Neoplasms / secondary. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 19119248.001).
  • [ISSN] 1738-222X
  • [Journal-full-title] The Korean journal of hepatology
  • [ISO-abbreviation] Korean J Hepatol
  • [Language] kor
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Korea (South)
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10. Yu RS, Chen Y, Jiang B, Wang LH, Xu XF: Primary hepatic sarcomas: CT findings. Eur Radiol; 2008 Oct;18(10):2196-205
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  • [Title] Primary hepatic sarcomas: CT findings.
  • Primary hepatic sarcomas are rare tumors that are difficult to diagnose clinically.
  • Different primary hepatic sarcomas may have different clinical, morphologic, and radiological features.
  • In this pictorial review, we summarized computed tomography (CT) findings of some relatively common types of hepatic sarcomas, including angiosarcoma, epithelioid hemangioendothelioma (EHE), liposarcoma, undifferentiated embryonal sarcoma (UES), leiomyosarcoma, malignant fibrous histiocytoma (MFH), and carcinosarcoma (including cystadenocarcinosarcoma).
  • To our knowledge, hepatic cystadenocarcinosarcoma has not been described in the English literature.
  • The advent of CT has allowed earlier detection of primary hepatic sarcomas as well as more accurate diagnosis and characterization.
  • In addition, we briefly discuss the MRI findings and diagnostic value of primary hepatic sarcomas.
  • [MeSH-major] Liver / diagnostic imaging. Liver Neoplasms / diagnostic imaging. Sarcoma / diagnostic imaging. Tomography, X-Ray Computed / methods

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  • (PMID = 18463872.001).
  • [ISSN] 0938-7994
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 53
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11. Infante PF, Petty SE, Groth DH, Markowitz G, Rosner D: Vinyl chloride propellant in hair spray and angiosarcoma of the liver among hairdressers and barbers: case reports. Int J Occup Environ Health; 2009 Jan-Mar;15(1):36-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Vinyl chloride propellant in hair spray and angiosarcoma of the liver among hairdressers and barbers: case reports.
  • Two cases of angiosarcoma of the liver (ASL) are, to the best of our knowledge, the first literature reports of such cases identified among hairdressers and barbers who used hair sprays containing vinyl chloride (VC) as a propellant.
  • As ASL is a sentinel cancer for exposure to VC, identification of these cases raises concern about the contribution of VC to hepatocellular carcinoma (HCC), a much more common type of liver cancer, as well as other VC-related cancers among hairdressers and barbers.
  • [MeSH-major] Aerosol Propellants / poisoning. Beauty Culture. Cosmetics / poisoning. Hemangiosarcoma / chemically induced. Liver Neoplasms / chemically induced. Occupational Diseases / chemically induced. Vinyl Chloride / poisoning

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  • (PMID = 19267125.001).
  • [ISSN] 1077-3525
  • [Journal-full-title] International journal of occupational and environmental health
  • [ISO-abbreviation] Int J Occup Environ Health
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Aerosol Propellants; 0 / Cosmetics; WD06X94M2D / Vinyl Chloride
  • [Number-of-references] 59
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12. Leowardi C, Hormann Y, Hinz U, Wente MN, Hallscheidt P, Flechtenmacher C, Buchler MW, Friess H, Schwarzbach MH: Ruptured angiosarcoma of the liver treated by emergency catheter-directed embolization. World J Gastroenterol; 2006 Feb 7;12(5):804-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ruptured angiosarcoma of the liver treated by emergency catheter-directed embolization.
  • Angiosarcoma is a rare primary malignant neoplasm of the liver with a poor prognosis.
  • Here, we report a case of a patient with a ruptured hepatic angiosarcoma which was treated by emergency catheter-directed embolization, followed by left-sided hemihepatectomy.
  • [MeSH-major] Embolization, Therapeutic. Hemangiosarcoma / therapy. Liver Neoplasms / therapy

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  • (PMID = 16521200.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 30
  • [Other-IDs] NLM/ PMC4066137
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13. Valbuena JR, Levenback C, Mansfield P, Liu J: Angiosarcoma of the spleen clinically presenting as metastatic ovarian cancer. A case report and review of the literature. Ann Diagn Pathol; 2005 Oct;9(5):289-92
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  • [Title] Angiosarcoma of the spleen clinically presenting as metastatic ovarian cancer. A case report and review of the literature.
  • Primary angiosarcomas of the spleen are rare and almost always fatal.
  • Grossly, this neoplasm appears as hemorrhagic and/or cystic nodules, with a low-density signal seen on computed tomographic scans.
  • The differential diagnosis includes a variety of benign and malignant vascular proliferations (littoral cell angioma and Kaposi's sarcoma) as well as metastatic tumors.
  • The liver is the most common site.
  • However, histopathologic examination of the specimen showed the tumor to be of a primary angiosarcoma.
  • We believe that the lengthy exposure to radiation may have played a role in the histopathogenesis of this neoplasm in this patient.
  • [MeSH-major] Hemangiosarcoma / pathology. Neoplasms, Second Primary / pathology. Ovarian Neoplasms / pathology. Splenic Neoplasms / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans


14. Bölke E, Gripp S, Peiper M, Budach W, Schwarz A, Orth K, Reinecke P, van de Nes JA: Multifocal epithelioid hemangioendothelioma: case report of a clinical chamaeleon. Eur J Med Res; 2006 Nov 30;11(11):462-6
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  • Various synonyms for epithelioid hemangioendothelioma are used clinically: low grade anaplastic angiosarcoma, cellular hemangioma, histiocytoid hemangioma and angioendothelioma.
  • Radiological findings revealed multiple lesions in the spine as well as liver and spleen involvement.
  • Tumor histology of the bone and liver biopsies confirmed the diagnosis of epithelioid hemangioendothelioma.
  • [MeSH-major] Hemangioendothelioma, Epithelioid / pathology. Liver Neoplasms / pathology. Spinal Neoplasms / pathology. Splenic Neoplasms / pathology
  • [MeSH-minor] Angiogenesis Inhibitors / therapeutic use. Diagnosis, Differential. Fatal Outcome. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Syndrome. Thalidomide / therapeutic use. Tomography, X-Ray Computed

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  • (PMID = 17182357.001).
  • [ISSN] 0949-2321
  • [Journal-full-title] European journal of medical research
  • [ISO-abbreviation] Eur. J. Med. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 4Z8R6ORS6L / Thalidomide
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15. Park YS, Kim JH, Kim KW, Lee IS, Yoon HK, Ko GY, Sung KB: Primary hepatic angiosarcoma: imaging findings and palliative treatment with transcatheter arterial chemoembolization or embolization. Clin Radiol; 2009 Aug;64(8):779-85
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  • [Title] Primary hepatic angiosarcoma: imaging findings and palliative treatment with transcatheter arterial chemoembolization or embolization.
  • AIM: To describe the image findings and results of transcatheter arterial chemoembolization (TACE) or transcatheter arterial embolization (TAE) for treating primary hepatic angiosarcoma.
  • MATERIALS AND METHODS: A retrospective review of the electronic medical database from 2002 to 2007, revealed six patients with primary hepatic angiosarcoma confirmed by percutaneous liver biopsy.
  • CONCLUSIONS: Primary hepatic angiosarcoma appears as a solitary or multiple, hypervascular lesions with heterogeneously early and progressive enhancement on CT and angiography.
  • Although TAE may be the primary procedure for achieving emergent bleeding control caused by the rupture of hepatic angiosarcomas, TACE may be effective for treating patients with a dominant hepatic angiosarcoma with or without intrahepatic metastases.
  • [MeSH-major] Hemangiosarcoma / radiography. Liver Neoplasms / radiography

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  • (PMID = 19589416.001).
  • [ISSN] 1365-229X
  • [Journal-full-title] Clinical radiology
  • [ISO-abbreviation] Clin Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; Q20Q21Q62J / Cisplatin
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16. Verge J, Albiol J, Navas M, Martín C: [Primary angiosarcoma of the spleen with liver metastases. Case report and literature review]. Cir Esp; 2005 Jul;78(1):50-2
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  • [Title] [Primary angiosarcoma of the spleen with liver metastases. Case report and literature review].
  • [Transliterated title] Angiosarcoma primario de bazo con metástasis hepáticas: presentación de un caso y revisión de la bibliografía.
  • Angiosarcomas of the spleen are infrequent tumors that often present with liver metastases.
  • Immunohistochemical markers can aid preoperative diagnosis since radiological and ultrasonographic images are fairly nonspecific.
  • [MeSH-major] Hemangiosarcoma / secondary. Hemangiosarcoma / surgery. Liver Neoplasms / secondary. Liver Neoplasms / surgery. Splenic Neoplasms / pathology. Splenic Neoplasms / surgery

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  • (PMID = 16420791.001).
  • [ISSN] 0009-739X
  • [Journal-full-title] Cirugía española
  • [ISO-abbreviation] Cir Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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17. Park JW, Serafica-Karen C, Das K: Fine-needle aspiration of metastatic radiation-induced cutaneous epithelioid angiosarcoma of the breast to the liver: A diagnostic dilemma. Diagn Cytopathol; 2010 Oct;38(10):768-71
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  • [Title] Fine-needle aspiration of metastatic radiation-induced cutaneous epithelioid angiosarcoma of the breast to the liver: A diagnostic dilemma.
  • Radiation therapy is a significant risk factor for the development of angiosarcoma.
  • With the increase in breast conservation treatment, the incidence of cutaneous radiation-induced angiosarcoma of the breast is rising.
  • If the angiosarcoma demonstrates epithelioid features, the tumor cells may present a diagnostic dilemma on fine-needle aspiration cytology.
  • We present a case of metastatic radiation-induced cutaneous epithelioid angiosarcoma of the breast to the liver and a review of the literature.
  • [MeSH-major] Biopsy, Fine-Needle. Liver Neoplasms / secondary. Neoplasms, Radiation-Induced / pathology
  • [MeSH-minor] Breast Neoplasms / metabolism. Breast Neoplasms / secondary. Carcinoma in Situ / radiotherapy. Carcinoma in Situ / surgery. Carcinoma, Ductal, Breast / radiotherapy. Carcinoma, Ductal, Breast / surgery. Cytodiagnosis. Diagnosis, Differential. Female. Hemangiosarcoma / metabolism. Hemangiosarcoma / secondary. Humans. Immunohistochemistry. Mastectomy, Segmental. Middle Aged. Radiotherapy, Adjuvant / adverse effects. Skin Neoplasms / metabolism. Skin Neoplasms / pathology

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  • [Copyright] © 2010 Wiley-Liss, Inc.
  • (PMID = 20187111.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] Angiosarcoma of the breast
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18. Bonaccorsi-Riani E, Lerut JP: Liver transplantation and vascular tumours. Transpl Int; 2010 Jul;23(7):686-91
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  • [Title] Liver transplantation and vascular tumours.
  • Based on analysis of the literature and of the audited ELITA (European Liver Intestinal Transplant Association)-ELTR (European Liver Transplant Registry) data, the place of liver transplantation (LT) in the treatment of vascular tumours is discussed.
  • Hepatic epithelioid haemangioendothelioma has currently become a good indication for LT with 5- and 10-year post-LT patient survival rates of 83% and 74% respectively and 5- and 10-year recurrence-free survival rates of 82% and 64% respectively.
  • The value of LT in the treatment of infantile haemangioendothelioma is more difficult to evaluate because of the very reduced number of reported cases and because of the often difficult differential diagnosis with angiosarcoma.
  • [MeSH-major] Hemangioendothelioma, Epithelioid / surgery. Hemangiosarcoma / surgery. Liver Neoplasms / surgery. Liver Transplantation. Vascular Neoplasms / surgery
  • [MeSH-minor] Biopsy. Child, Preschool. Diagnostic Errors. Hepatectomy. Humans. Infant. Liver / pathology. Liver / surgery. Neoplasm Recurrence, Local. Registries. Survival Rate

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  • (PMID = 20492619.001).
  • [ISSN] 1432-2277
  • [Journal-full-title] Transplant international : official journal of the European Society for Organ Transplantation
  • [ISO-abbreviation] Transpl. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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19. Kim HR, Rha SY, Cheon SH, Roh JK, Park YN, Yoo NC: Clinical features and treatment outcomes of advanced stage primary hepatic angiosarcoma. Ann Oncol; 2009 Apr;20(4):780-7
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  • [Title] Clinical features and treatment outcomes of advanced stage primary hepatic angiosarcoma.
  • BACKGROUND: Primary hepatic angiosarcoma is a very rare malignancy with a poor prognosis.
  • PATIENTS AND METHODS: Among 11,939 patients diagnosed with primary hepatic tumors from January 1985 to December 2007 at two centers, five patients were diagnosed with primary hepatic angiosarcoma.
  • Two of four patients who received chemotherapy died <3 months after diagnosis, but the other two patients survived >6 months.
  • This case study may aid in planning chemotherapy for patients with advanced hepatic angiosarcoma.

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  • (PMID = 19179547.001).
  • [ISSN] 1569-8041
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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20. Schwartz J, Hatch J, Shaaban A, Hutson W: Education and Imaging. Hepatobiliary and pancreatic: angiosarcoma of the liver. J Gastroenterol Hepatol; 2010 May;25(5):1016
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  • [Title] Education and Imaging. Hepatobiliary and pancreatic: angiosarcoma of the liver.
  • [MeSH-major] Hemangiosarcoma / diagnosis. Liver Neoplasms / diagnosis

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  • (PMID = 20546460.001).
  • [ISSN] 1440-1746
  • [Journal-full-title] Journal of gastroenterology and hepatology
  • [ISO-abbreviation] J. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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21. Deyrup AT, McKenney JK, Tighiouart M, Folpe AL, Weiss SW: Sporadic cutaneous angiosarcomas: a proposal for risk stratification based on 69 cases. Am J Surg Pathol; 2008 Jan;32(1):72-7
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  • [Title] Sporadic cutaneous angiosarcomas: a proposal for risk stratification based on 69 cases.
  • Angiosarcomas have traditionally been considered high-grade lesions for which histologic features and grading have played no role in prognostication and, consequently, they have been excluded from the American Joint Committee on Cancer staging system.
  • We have, therefore, analyzed 69 cutaneous angiosarcomas seen in consultation and not associated with lymphedema or prior radiation therapy to determine if a combination of histologic and clinical parameters could be used to differentiate indolent from aggressive tumors.
  • Recurrences developed in 18 patients (26%) and metastasis in 15 (22%) to the following sites: lung (6), lymph node (7), liver (2), bone (2), and parotid gland (1).
  • In conclusion, we report that a combination of clinical and histologic features allows stratification of angiosarcoma patients into 2 risk groups that are strongly associated with marked differences in clinical course.
  • [MeSH-major] Hemangiosarcoma / pathology. Skin Neoplasms / pathology

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  • (PMID = 18162773.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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22. Solomon GJ, Kinkhabwala MM, Akhtar M: Inflammatory myofibroblastic tumor of the liver. Arch Pathol Lab Med; 2006 Oct;130(10):1548-51
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  • [Title] Inflammatory myofibroblastic tumor of the liver.
  • We report a case of hepatic inflammatory myofibroblastic tumor in a 26-year-old African American man who presented with right upper quadrant pain, weight loss, and fatigue during the previous year.
  • A left partial hepatectomy was performed; the preoperative differential diagnosis was for angiosarcoma and hepatocellular carcinoma.
  • The resected liver specimen showed 2 contiguous, firm, tan-white nodules that microscopically represented a proliferation of spindled myofibroblast cells set in an inflammatory and collagenized background.
  • The morphologic and immunophenotypic findings, coupled with the clinical presentation, were consistent with an inflammatory myofibroblastic tumor of the liver.
  • [MeSH-major] Liver Neoplasms / pathology. Neoplasms, Muscle Tissue / pathology
  • [MeSH-minor] Actins / metabolism. Adult. Diagnosis, Differential. Hepatectomy. Hepatomegaly / etiology. Humans. Immunohistochemistry. Immunophenotyping. Inflammation / metabolism. Inflammation / pathology. Magnetic Resonance Imaging. Male. Muscle, Smooth / metabolism

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  • (PMID = 17090200.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins
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23. Ikeda K, Maehara M, Ohmura N, Kurokawa H, Koda K, Yokoyama H, Sawada S: Spontaneous rupture of a necrotic hepatic angiosarcoma: findings on dual-phase computed tomography and angiography. Radiat Med; 2006 Jun;24(5):369-72
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  • [Title] Spontaneous rupture of a necrotic hepatic angiosarcoma: findings on dual-phase computed tomography and angiography.
  • We present dual-phase computed tomographic (CT) and angiographic findings of a ruptured hepatic angiosarcoma.
  • We found that dual-phase CT and angiographic findings are able to distinguish angiosarcoma, which mimics a hemangioma, as these lesions show avascular areas that reflect a mass with gross central necrosis.
  • [MeSH-major] Hemangiosarcoma / diagnostic imaging. Liver Neoplasms / diagnostic imaging. Tomography, X-Ray Computed / methods

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  • (PMID = 16958416.001).
  • [ISSN] 0288-2043
  • [Journal-full-title] Radiation medicine
  • [ISO-abbreviation] Radiat Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
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24. Willmann JK, Cheng Z, Davis C, Lutz AM, Schipper ML, Nielsen CH, Gambhir SS: Targeted microbubbles for imaging tumor angiogenesis: assessment of whole-body biodistribution with dynamic micro-PET in mice. Radiology; 2008 Oct;249(1):212-9
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  • These MBs were then injected intravenously into nude mice (n = 4) bearing angiosarcomas, and the whole-body biodistribution of these probes was assessed for 60 minutes by using dynamic micro-PET.
  • Control studies in angiosarcoma-bearing mice were performed with injection of the radiolabeled antibodies alone (n = 3) or free SFB (n = 3).
  • RESULTS: VEGFR2-targeted MBs rapidly cleared from the blood circulation (50% blood clearance after approximately 3.5 minutes) and accumulated in the liver (mean, 33.4% injected dose [ID]/g +/- 13.7 [standard deviation] at 60 minutes) and spleen (mean, 9.3% ID/g +/- 6.5 at 60 minutes) on the basis of micro-PET imaging.
  • Immunofluorescence staining demonstrated accumulation of the targeted MBs within hepatic Kupffer cells and splenic macrophages.

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  • [Copyright] (c) RSNA, 2008.
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  • (PMID = 18695212.001).
  • [ISSN] 1527-1315
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / 1 R01 HL078632; United States / NCI NIH HHS / CA / CA114747 P50
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies; 0 / Benzoates; 0 / Fluorocarbons; 0 / N-succinimidyl 4-(fluoromethyl)benzoate; 0 / Succinimides; EC 2.7.10.1 / Vascular Endothelial Growth Factor Receptor-2
  • [Other-IDs] NLM/ PMC2657857
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25. Khalil MF, Thomas A, Aassad A, Rubin M, Taub RN: Epithelioid Angiosarcoma of the Small Intestine After Occupational Exposure to Radiation and Polyvinyl Chloride: A case Report and Review of Literature. Sarcoma; 2005;9(3-4):161-4
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  • [Title] Epithelioid Angiosarcoma of the Small Intestine After Occupational Exposure to Radiation and Polyvinyl Chloride: A case Report and Review of Literature.
  • Angiosarcomas represent 1-2% of soft tissue sarcomas and most frequently occur in the subcutis.
  • They may affect internal organs, such as the heart, liver, and spleen, and only rarely do they emerge in the gastrointestinal tract.
  • The association between angiosarcomas and certain toxic chemical substances or previous external-beam radiation therapy is well documented.

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  • (PMID = 18521426.001).
  • [ISSN] 1357-714X
  • [Journal-full-title] Sarcoma
  • [ISO-abbreviation] Sarcoma
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC2395632
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26. Fischer HP, Flucke U, Zhou H: [Pathology along the liver sinusoids: endothelial and perisinusoidal findings]. Pathologe; 2008 Feb;29(1):37-46
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  • [Title] [Pathology along the liver sinusoids: endothelial and perisinusoidal findings].
  • [Transliterated title] Pathologie entlang der sinusoidalen Wegstrecke: sinusendotheliale und perisinusoidale Befunde.
  • Sinusoidal alterations unrelated to primary hepatocellular damage present without characteristic clinical findings and in these cases the liver biopsy is particularly important.
  • In large regenerative nodules, focal nodular hyperplasia and liver cell adenoma CD34-positive capillaries reflect afferent parts and CD34-negative sinusoids the efferent parts of the parenchymal vascular bed.
  • Hepatic angiosarcomas and epithelioid hemangioendotheliomas can be easily overseen in liver biopsies, if they spread along the sinusoids without detoriation of the acinar architecture and without significant alteration of the surrounding liver cell plates.
  • In these cases liver biopsy might disclose occlusion of the terminal liver veins (VOD).
  • Perisinusoidal fibrosis can be caused by intrasinusoidal accumulation of pathologic cells, advanced intrasinusoidal macrophagocytic storage diseases and by activation of the vitamin A-storing hepatic stellate cells.
  • [MeSH-major] Biopsy / methods. Endothelial Cells / pathology. Hepatic Veno-Occlusive Disease / pathology. Liver / pathology. Liver Neoplasms / pathology
  • [MeSH-minor] Antigens, CD / analysis. Antigens, CD34 / analysis. Hepatic Veins / pathology. Humans. Liver Circulation. Liver Cirrhosis / pathology. Vasodilation

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  • (PMID = 18210108.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD34
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27. Shimada K, Nakamoto Y, Isoda H, Saito H, Arizono S, Shibata T, Togashi K: FDG PET for giant cavernous hemangioma: important clue to differentiate from a malignant vascular tumor in the liver. Clin Nucl Med; 2010 Dec;35(12):924-6
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  • [Title] FDG PET for giant cavernous hemangioma: important clue to differentiate from a malignant vascular tumor in the liver.
  • Giant cavernous hemangioma of the liver sometimes has a very inhomogeneous appearance with intratumoral degeneration on computed tomography or magnetic resonance imaging, and may mimic a malignant hepatic tumor, including angiosarcoma.
  • There are many reports about F-18 fluorodeoxyglucose (FDG) uptake of angiosarcoma; however, knowledge regarding positron emission tomography findings with FDG for giant hepatic cavernous hemangioma is still limited.
  • We herein present 2 cases of giant hepatic cavernous hemangioma in which low FDG uptake was considered helpful to differentiate from malignant hepatic tumor.
  • [MeSH-major] Fluorodeoxyglucose F18. Hemangioma, Cavernous / radionuclide imaging. Liver Neoplasms / radionuclide imaging. Positron-Emission Tomography
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Middle Aged

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  • (PMID = 21206221.001).
  • [ISSN] 1536-0229
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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28. Hosokawa Y, Kodani E, Kusama Y, Kamiya M, Yoshikawa M, Hirasawa Y, Nakagomi A, Atarashi H, Maeda S, Mizuno K: Cardiac angiosarcoma diagnosed by transvenous endomyocardial biopsy with the aid of transesophageal echocardiography and intra-procedural consultation. Int Heart J; 2010;51(5):367-9
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  • [Title] Cardiac angiosarcoma diagnosed by transvenous endomyocardial biopsy with the aid of transesophageal echocardiography and intra-procedural consultation.
  • Transthoracic echocardiography (TTE) and contrast-enhanced computed tomography (CT) scans demonstrated a large mass in the right atrium and multiple liver tumors thought to be due to spread of the disease.
  • In order to confirm the histological diagnosis, we attempted transvenous endomyocardial tumor biopsy under fluoroscopic guidance.
  • These findings indicated a definite diagnosis of angiosarcoma.
  • [MeSH-major] Biopsy / methods. Heart Neoplasms / diagnosis. Heart Neoplasms / pathology. Hemangiosarcoma / pathology. Ultrasonography, Interventional / methods
  • [MeSH-minor] Coronary Angiography. Dose Fractionation. Echocardiography, Transesophageal. Female. Humans. Immunohistochemistry. Liver Neoplasms / radiography. Liver Neoplasms / secondary. Middle Aged. Referral and Consultation. Tomography, X-Ray Computed

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  • (PMID = 20966612.001).
  • [ISSN] 1349-3299
  • [Journal-full-title] International heart journal
  • [ISO-abbreviation] Int Heart J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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29. Fayette J, Martin E, Piperno-Neumann S, Le Cesne A, Robert C, Bonvalot S, Ranchère D, Pouillart P, Coindre JM, Blay JY: Angiosarcomas, a heterogeneous group of sarcomas with specific behavior depending on primary site: a retrospective study of 161 cases. Ann Oncol; 2007 Dec;18(12):2030-6
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  • [Title] Angiosarcomas, a heterogeneous group of sarcomas with specific behavior depending on primary site: a retrospective study of 161 cases.
  • BACKGROUND: Angiosarcomas are rare, heterogeneous and a retrospective study was conducted to describe their natural history.
  • PATIENTS AND METHODS: We reviewed 161 files of angiosarcoma treated in three institutions of the French Sarcoma Group from 1980 to 2004.
  • Primary sites were the breast (35%), skin (20%) and soft tissues (13%).
  • At initial diagnosis, 31 (19%) had metastases.
  • With an average time since initial diagnosis of 8.1 years, 123 (76%) patients progressed and 76 (47%) died.
  • In multivariate analysis, liver primary site [relative risk (RR) = 12.62], performance status (PS) of two or more (RR = 3.83), presence of metastases at diagnosis (RR = 2.50), soft tissue tumor (RR = 0.31) were correlated to OS.
  • PS, liver and soft tissue tumors were identified as independent prognostic factors for progression-free survival.
  • CONCLUSIONS: Angiosarcomas have an overall poor outcome, but with a clearly distinct prognosis depending on the primary site.

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  • (PMID = 17974557.001).
  • [ISSN] 1569-8041
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] England
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30. Kim HR, Kim TW: Occupational hepatic disorders in Korea. J Korean Med Sci; 2010 Dec;25(Suppl):S36-40
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  • [Title] Occupational hepatic disorders in Korea.
  • Occupational hepatic disorders are classified into toxic hepatitis, viral hepatitis, and chemical-induced malignancy in Korea.
  • Hepatic angiosarcoma caused by vinyl chloride monomer (VCM) exposure is a very well known occupational disease and it has not been officially reported in Korea yet.
  • [MeSH-major] Liver Diseases / epidemiology. Occupational Diseases / chemically induced. Occupational Diseases / epidemiology
  • [MeSH-minor] Adult. Drug-Induced Liver Injury / epidemiology. Female. Health Personnel. Hepatitis, Viral, Human / epidemiology. Hepatitis, Viral, Human / prevention & control. Humans. Liver Neoplasms / chemically induced. Liver Neoplasms / epidemiology. Male. Middle Aged. Occupational Exposure / adverse effects. Republic of Korea / epidemiology. Young Adult

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  • (PMID = 21258588.001).
  • [ISSN] 1598-6357
  • [Journal-full-title] Journal of Korean medical science
  • [ISO-abbreviation] J. Korean Med. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC3023346
  • [Keywords] NOTNLM ; Dimethylformamide / Drug-Induced Liver Injury / Health Care Workers / Trichloroethylene / Viral Hepatitis
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31. Wang J, Li Q, Sun Y, Cui YL: [A case of angiosarcoma developed from liver hamartomas]. Zhonghua Gan Zang Bing Za Zhi; 2006 Sep;14(9):717
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  • [Title] [A case of angiosarcoma developed from liver hamartomas].
  • [MeSH-major] Hamartoma / pathology. Hemangiosarcoma / pathology. Liver Neoplasms / pathology

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  • (PMID = 16996000.001).
  • [ISSN] 1007-3418
  • [Journal-full-title] Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology
  • [ISO-abbreviation] Zhonghua Gan Zang Bing Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
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32. Zhou ML, Yan FH, Ye F, Xiong Z, Wang JH, Ji Y: [Images of primary hepatic angiosarcomas]. Zhonghua Gan Zang Bing Za Zhi; 2008 Feb;16(2):136-7
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  • [Title] [Images of primary hepatic angiosarcomas].
  • [MeSH-major] Hemangiosarcoma / radiography. Liver Neoplasms / radiography. Tomography, X-Ray Computed

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  • (PMID = 18304433.001).
  • [ISSN] 1007-3418
  • [Journal-full-title] Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology
  • [ISO-abbreviation] Zhonghua Gan Zang Bing Za Zhi
  • [Language] chi
  • [Publication-type] Journal Article
  • [Publication-country] China
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33. Deyrup AT, Tighiouart M, Montag AG, Weiss SW: Epithelioid hemangioendothelioma of soft tissue: a proposal for risk stratification based on 49 cases. Am J Surg Pathol; 2008 Jun;32(6):924-7
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  • Epithelioid hemangioendothelioma (EHE) of soft tissue is a distinctive vascular tumor that has been variously considered a tumor of borderline malignancy and low-grade angiosarcoma.
  • Eleven patients (22%) had metastatic disease affecting lung (6), lymph node (4), liver (2), and bone, retroperitoneum, and soft tissue (1 each).
  • [MeSH-major] Hemangioendothelioma, Epithelioid / diagnosis. Soft Tissue Neoplasms / diagnosis

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  • (PMID = 18551749.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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34. den Hoed ID, Granzen B, Granzen B, Aronson DC, Pauwels P, de Kraker J, van Heurn LW: Metastasized angiosarcoma of the spleen in a 2-year-old girl. Pediatr Hematol Oncol; 2005 Jul-Aug;22(5):387-90
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  • [Title] Metastasized angiosarcoma of the spleen in a 2-year-old girl.
  • Primary angiosarcoma of the spleen is rare and the prognosis is very poor.
  • The authors present a 2-year-old girl with spontaneous rupture of splenic angiosarcoma.
  • At diagnosis there were liver metastases.
  • After splenectomy she received chemotherapy with ifosfamide, vincristine, and actinomycine D combined with a partial liver resection.
  • She remained in complete remission over 2 years from diagnosis.
  • [MeSH-major] Hemangiosarcoma / secondary. Liver Neoplasms / secondary. Splenic Neoplasms / pathology
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Child, Preschool. Female. Hepatectomy. Humans. Neoplasm Metastasis. Prognosis. Remission Induction

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  • (PMID = 16020128.001).
  • [ISSN] 0888-0018
  • [Journal-full-title] Pediatric hematology and oncology
  • [ISO-abbreviation] Pediatr Hematol Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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35. Gambino G, Mannone T, Rizzo A, Scio A, Branca M, Airò Farulla M, Guccione M, Spallitta IS, Nicoli N: Adrenal epithelioid angiosarcoma: a case report. Chir Ital; 2008 May-Jun;60(3):463-7
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  • [Title] Adrenal epithelioid angiosarcoma: a case report.
  • We report what to the best of our knowledge is the first case of primary angiosarcoma of the adrenal gland.
  • Computed tomography revealed a suspected rupture of a liver neoplasm and surgical treatment was performed.
  • At laparotomy there was no evidence of liver tumour but a large mass was found in the right adrenal gland.
  • [MeSH-major] Adrenal Gland Neoplasms. Hemangiosarcoma

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  • (PMID = 18709789.001).
  • [ISSN] 0009-4773
  • [Journal-full-title] Chirurgia italiana
  • [ISO-abbreviation] Chir Ital
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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36. Oztürk E, Mutlu H, Sönmez G, Sildiroğlu HO: Primary angiosarcoma of the spleen. Turk J Gastroenterol; 2007 Dec;18(4):272-5
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  • [Title] Primary angiosarcoma of the spleen.
  • Primary angiosarcoma of the spleen is a rare neoplasm with a very poor prognosis.
  • We present computed tomography and magnetic resonance imaging of a 49-year-old man with primary splenic angiosarcoma and liver metastasis.
  • The literature on primary splenic angiosarcoma is reviewed and imaging variability of this rare tumor is discussed.
  • [MeSH-major] Hemangiosarcoma / diagnosis. Splenic Neoplasms / diagnosis

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  • (PMID = 18080928.001).
  • [ISSN] 2148-5607
  • [Journal-full-title] The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
  • [ISO-abbreviation] Turk J Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Turkey
  • [Number-of-references] 23
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37. Hoshi N, Mukai S, Oishi M, Takano M, Shinzawa J, Watanabe S, Yamazaki S, Sakuma H, Ohira H, Obara K, Kasukawa R, Sato Y: A case of hepatic angiosarcoma supplied by both hepatic artery and portal vein. Fukushima J Med Sci; 2006 Jun;52(1):13-9
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  • [Title] A case of hepatic angiosarcoma supplied by both hepatic artery and portal vein.
  • Liver neoplasms, whether they are benign or malignant, are usually fed by the hepatic artery.
  • We experienced a case of hepatic angiosarcoma supplied by both hepatic artery and portal vein.
  • Since there are currently no specific laboratory tests to diagnose hepatic angiosarcoma, it is important to detect suspect cases from imaging features.
  • This unique hemodynamic property was detected on computed tomography (CT) during hepatic arteriography and CT during hepatic arterioportography.
  • If any imaging examinations indicate the liver tumor to be fed by the portal vein, hepatic angiosarcoma should be suspected.
  • [MeSH-major] Hemangiosarcoma / blood supply. Hepatic Artery / radiography. Liver Neoplasms / blood supply. Portal Vein / radiography
  • [MeSH-minor] Angiography. Humans. Liver / blood supply. Liver / pathology. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 16995350.001).
  • [ISSN] 0016-2590
  • [Journal-full-title] Fukushima journal of medical science
  • [ISO-abbreviation] Fukushima J Med Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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38. Liang YM, Li XH, Lü YL, Zhong M: [Morphology and immunohistochemical characteristics of hepatic primary and metastatic malignant spindle cell tumors]. Zhonghua Yi Xue Za Zhi; 2005 Jan 12;85(2):96-100
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  • [Title] [Morphology and immunohistochemical characteristics of hepatic primary and metastatic malignant spindle cell tumors].
  • OBJECTIVE: To investigate the morphology and immunohistochemical characteristics of hepatic primary and metastatic malignant spindle cell tumors, and to conclude the diagnostic and differential diagnostic criteria for these morphologically similar tumors.
  • METHODS: Forty-six specimens of hepatic spindle cell tumors.
  • 20 primary tumors (43.4%), including 3 cases of sarcomatoid carcinoma (6.5%), 11 of angiosarcoma (23.9%), 2 of epithelioid hemangioendothelioma (5%), 1 of spindle cell carcinoid (2.2%), and 3 of undifferentiated sarcoma (6.5%).
  • and 26 metastatic malignant tumors (56.5%), including 20 cases of gastrointestinal stromal tumors (GIST, 43.4%), 3 of leiomyosarcoma (6.5%), 2 of malignant peripheral never sheath tumor (4.3%), and 1 of meningeal hemangiopericytoma (2.2%), resected during operation or collected during imaging-mediated liver puncture underwent hematoxylin-eosin staining, SP staining, and EnVision immunohistochemical staining.
  • RESULTS: Either primary or metastatic tumors showed extensive overlapping in histopathologic appearance, and hemangiopericytoma-like structure was the predominant pattern, which could be seen in nearly every kind of hepatic spindle cell tumors.
  • Most stromal tumor cases were CD117 positive, and existed the condition that the primary tumor was positive and the metastatic tumor was negative or vice versa or one part of specimen was positive but other part was negative.
  • Leiomyosarcoma was immunoreactive to smooth muscle specific antigen (SMA), malignant peripheral nerve sheath tumor was immunoreactive to S-100 protein and neurofilament (NF), and both were CD117 negative.
  • Angiosarcoma and epithelioid hemangioendothelioma expressed different immunoreactivity to CD31, CD34 and factor VIII related antigen.
  • CONCLUSION: Primary angiosarcoma is the most common form of primary spindle cell tumor in liver, and metastatic GIST is predominant in hepatic metastatic spindle cell tumors.
  • A penal of immunohistochemical markers is necessary for the final diagnosis of these tumors because of the complexity and similarity of different tumors of this kind.
  • [MeSH-major] Carcinoma / pathology. Hemangiosarcoma / pathology. Liver Neoplasms / pathology

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  • (PMID = 15774214.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Antigens, CD34; 0 / Biomarkers, Tumor
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39. Askri A, Mannai S, Landolsi S, Ben Farhat L, Said W, Dali N, Khalfallah MT, Hendaoui L: [Hepatic epithelioid hemangioendothelioma: review of 3 cases]. J Radiol; 2009 Mar;90(3 Pt 1):310-4
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  • [Title] [Hepatic epithelioid hemangioendothelioma: review of 3 cases].
  • Hepatic epithelioid hemangioendothelioma (EHE) is a rare neoplasm of vascular origin.
  • EHE is an intermediate-grade malignancy, between benign hemangioma and angiosarcoma, with variable aggressiveness.
  • Involvement often is multinodular simulating metastases from a primatry extra-hepatic malignancy leading to delays in diagnosis.
  • We report the imaging features in three cases of histologically proven hepatic EHE.
  • The imaging features suggestive of EHE will be emphasized, especially for multinodular lesions suggesting liver metastases in patients with no known primary.
  • [MeSH-major] Hemangioendothelioma, Epithelioid / diagnosis. Liver Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Contrast Media. Female. Hepatectomy. Humans. Immunohistochemistry. Liver / pathology. Magnetic Resonance Imaging / methods. Middle Aged. Tomography, X-Ray Computed / methods

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  • (PMID = 19421116.001).
  • [ISSN] 0221-0363
  • [Journal-full-title] Journal de radiologie
  • [ISO-abbreviation] J Radiol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Contrast Media
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40. Halkes CJ, Dijstelbloem HM, Eelkman Rooda SJ, Kramer MH: Extreme leucocytosis: not always leukaemia. Neth J Med; 2007 Jul-Aug;65(7):248-51
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  • This reaction was associated with a hepatic angiosarcoma in the first patient, with a Salmonella infection in the second patient and with a necrotic leg abscess in the third patient.
  • [MeSH-major] Leukemoid Reaction / etiology. Leukocytosis / diagnosis. Leukocytosis / etiology. Paraneoplastic Syndromes
  • [MeSH-minor] Abscess / complications. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Hemangiosarcoma / complications. Humans. Leg / physiopathology. Leukemia. Liver / physiopathology. Male. Salmonella Infections / complications

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  • (PMID = 17656811.001).
  • [ISSN] 0300-2977
  • [Journal-full-title] The Netherlands journal of medicine
  • [ISO-abbreviation] Neth J Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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41. Kostov D, Kobakov G, Dragnev N: [Operative-technical special features of the left lobectomy in colorectal cancer liver metastases]. Khirurgiia (Sofiia); 2006;(6):8-11
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  • [Title] [Operative-technical special features of the left lobectomy in colorectal cancer liver metastases].
  • The indications of the liver resection are the primary and secondary malignant neoplasms of the liver, the benign liver tumors and some inflammatory diseases.
  • Approximately 10-30% of the patients with colorectal cancer liver metastases are suitable to a curative liver resection.
  • The aim of the study is to presenti of the operative-technical special features of the anatomical left lobectomy of patients with colorectal cancer liver metastases.
  • In the course of 24 months we carried out 9 anatomical left liver resections.
  • The indications of the operation of eight of them were solitary metastases, which had appeared after an operation on colorectal cancer and at one of them the resection was performed due to an angiosarcoma of the liver.
  • The liver resection highly improves the prognosis on the following conditions: a radical treatment of the primary tumor, an absence of local recurrence, an absence of an extrahepatic incidence of the primary tumor and a preservation of a sufficient capacity of the liver.
  • [MeSH-major] Adenocarcinoma / surgery. Colorectal Neoplasms / pathology. Hepatectomy / methods. Liver Neoplasms / surgery


42. Bioulac-Sage P, Laumonier H, Laurent C, Blanc JF, Balabaud C: Benign and malignant vascular tumors of the liver in adults. Semin Liver Dis; 2008 Aug;28(3):302-14
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  • [Title] Benign and malignant vascular tumors of the liver in adults.
  • Vascular tumors of the liver in adult patients include cavernous hemangioma, a common benign tumor; epithelioid hemangioendothelioma, a rare, usually low-grade malignant tumor; and angiosarcoma, a rare and very aggressive tumor.
  • All these primary mesenchymal tumors develop on a normal liver and may also affect other organs.
  • Hepatic tumors are increasingly detected incidentally due to widespread use of modern abdominal imaging techniques.
  • Therefore, reliable noninvasive characterization and differentiation of such liver tumors is of major importance for clinical practice.
  • A definitive diagnosis of epithelioid hemangioendothelioma and angiosarcoma requires histopathologic examination.
  • Liver transplantation at an early stage has greatly improved the prognosis of epithelioid hemangioendothelioma.
  • The prognosis of angiosarcoma remains dismal.
  • [MeSH-major] Liver / blood supply. Liver Neoplasms. Neoplasms, Vascular Tissue
  • [MeSH-minor] Adult. Hemangioendothelioma, Epithelioid / pathology. Hemangioendothelioma, Epithelioid / therapy. Hemangioma, Cavernous / pathology. Hemangioma, Cavernous / therapy. Hemangiosarcoma / pathology. Hemangiosarcoma / therapy. Hepatic Stellate Cells / pathology. Humans. Sarcoma, Kaposi / pathology. Sarcoma, Kaposi / therapy. Treatment Outcome

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  • (PMID = 18814083.001).
  • [ISSN] 0272-8087
  • [Journal-full-title] Seminars in liver disease
  • [ISO-abbreviation] Semin. Liver Dis.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 45
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43. Fujii T, Zen Y, Sato Y, Sasaki M, Enomae M, Minato H, Masuda S, Uehara T, Katsuyama T, Nakanuma Y: Podoplanin is a useful diagnostic marker for epithelioid hemangioendothelioma of the liver. Mod Pathol; 2008 Feb;21(2):125-30
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  • [Title] Podoplanin is a useful diagnostic marker for epithelioid hemangioendothelioma of the liver.
  • However, its expression in non-neoplastic and neoplastic liver tissues has not been well documented.
  • In this study, we examined podoplanin expression in specimens from 10 normal livers and 73 cases of liver tumors: hemangioma (16 cases), epithelioid hemangioendothelioma (9 cases), angiosarcoma (4 cases), angiomyolipoma (7 cases), hepatocellular carcinoma (11 cases), intrahepatic cholangiocarcinoma (11 cases), and metastatic liver cancer (15 cases).
  • We compared levels of podoplanin and other endothelial markers (CD31, CD34, and factor VIII) in liver tumors.
  • In the normal liver, podoplanin was expressed in lymphatic endothelium, nerve fibers, and mesothelium in the hepatic capsule, but not observed in any cells within hepatic lobules.
  • Among liver tumors, podoplanin was specifically expressed in seven of nine cases (78%) of epithelioid hemangioendothelioma but not in other hepatic tumors.
  • The expression of CD31, CD34, and factor VIII was observed in endothelial cells in all cases of hemangioma, epithelioid hemangioendothelioma, angiosarcoma, and angiomyolipoma with one exception, a case of epithelioid hemangioendothelioma which was without CD31 expression.
  • In conclusion, podoplanin would be useful as a diagnostic marker for epithelioid hemangioendothelioma in liver tumors.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Hemangioendothelioma, Epithelioid / metabolism. Liver Neoplasms / metabolism. Membrane Glycoproteins / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Angiomyolipoma / metabolism. Angiomyolipoma / pathology. Bile Duct Neoplasms / metabolism. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / metabolism. Bile Ducts, Intrahepatic / pathology. Carcinoma, Hepatocellular / metabolism. Carcinoma, Hepatocellular / pathology. Cholangiocarcinoma / metabolism. Cholangiocarcinoma / pathology. Diagnosis, Differential. Endothelium, Lymphatic / metabolism. Endothelium, Lymphatic / pathology. Female. Hemangioma / metabolism. Hemangioma / pathology. Hemangiosarcoma / metabolism. Hemangiosarcoma / pathology. Humans. Liver / metabolism. Liver / pathology. Male. Middle Aged

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  • (PMID = 18084256.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Membrane Glycoproteins; 0 / PDPN protein, human
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44. Balamurali G, du Plessis DG, Wengoy M, Bryan N, Herwadkar A, Richardson PL: Thorotrast-induced primary cerebral angiosarcoma: case report. Neurosurgery; 2009 Jul;65(1):E210-1; discussion E211
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  • [Title] Thorotrast-induced primary cerebral angiosarcoma: case report.
  • Gliosarcomas, meningiomas, and schwannomas have been reported previously, as has Thorotrast-associated angiosarcoma, typically in the liver.
  • A unique case of a primary intracerebral well-differentiated angiosarcoma in a 68-year-old man with a history of colocalized exposure to Thorotrast is described.
  • This may be the first case of a primary angiosarcoma in the brain.
  • Primary lesions of the central nervous system associated with Thorotrast are very rarely reported, despite its extensive use in cerebral angiography and management of brain abscess between 1930 and 1960.
  • [MeSH-major] Brain Neoplasms / chemically induced. Carcinogens / pharmacology. Hemangiosarcoma / chemically induced. Hemangiosarcoma / diagnosis. Thorium Dioxide / pharmacology

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  • (PMID = 19574803.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens; 9XA7X17UQC / Thorium Dioxide
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45. Tate G, Suzuki T, Mitsuya T: Mutation of the PTEN gene in a human hepatic angiosarcoma. Cancer Genet Cytogenet; 2007 Oct 15;178(2):160-2
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  • [Title] Mutation of the PTEN gene in a human hepatic angiosarcoma.
  • The PTEN protein inhibits angiogenesis, and somatic mutations of the PTEN gene are involved in canine hemangiosarcoma.
  • We screened for mutations of the PTEN gene in two patients with human hepatic angiosarcoma to determine whether PTEN is involved in the pathogenesis of human hepatic angiosarcoma.
  • In one patient, who suffered from breast cancer, pharyngeal cancer, and hepatic angiosarcoma, we found a single base substitution in exon 7 (640C>T) of the PTEN gene in both the hepatic angiosarcoma and normal tissues.
  • These findings indicate that analysis of PTEN gene mutations may be useful for characterization of the molecular event in hepatic angiosarcoma and cancer predisposition.
  • [MeSH-major] Hemangiosarcoma / genetics. Liver Neoplasms / genetics. Mutation. PTEN Phosphohydrolase / genetics

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  • (PMID = 17954274.001).
  • [ISSN] 0165-4608
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.1.3.48 / PTEN protein, human; EC 3.1.3.67 / PTEN Phosphohydrolase
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46. Bolt HM: Vinyl chloride-a classical industrial toxicant of new interest. Crit Rev Toxicol; 2005 Apr-May;35(4):307-23
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  • The carcinogenicity of vinyl chloride in humans was recognized in 1974 based on observations of hepatic angiosarcomas in highly exposed workers.
  • The primary target organ, the liver, displays differential susceptibilities of hepatocytes and sinusoidal cells, which are modified by factors of age and dose.
  • Vinyl chloride is a pluripotent carcinogen, predominantly directed toward hepatic endothelial (sinusoidal) cells, and second toward the parenchymal cells of the liver.
  • This is consistent with the plateau of hepatic angiosarcoma incidence in rat bioassays.
  • Published risk estimates based on different sets of data (animal experiments, epidemiological studies) appear basically consistent, and on this basis an angiosarcoma risk of approximately 3 x 10(-4) has been deduced by extrapolation, for exposure to 1 ppm vinyl chloride over an entire human working lifetime.

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  • (PMID = 15989139.001).
  • [ISSN] 1040-8444
  • [Journal-full-title] Critical reviews in toxicology
  • [ISO-abbreviation] Crit. Rev. Toxicol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens; 0 / Mutagens; 9007-49-2 / DNA; WD06X94M2D / Vinyl Chloride
  • [Number-of-references] 170
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47. Le Scanff J, Durupt S, Bailly F, Rode A, Sève P: A strange Evans syndrome: a case report. Cases J; 2009;2:8001
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  • Hepatic angiosarcoma is a rare malignant vascular tumor, which accounts for up to 2% of all primary liver tumors.
  • Diagnosis of diffuse hepatic angiosarcoma can be challenging.
  • We report an original case of diffuse liver angiosarcoma revealed by haematological abnormalities initially diagnosed as an Evans syndrome.
  • Diagnosis of diffuse liver angiosarcoma can be extremely difficult and physicians should be aware of these presentation.

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  • [Cites] Medicina (B Aires). 1997;57(5):587-90 [9674228.001]
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  • (PMID = 19830043.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2740225
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48. Vasanawala MS, Wang Y, Quon A, Gambhir SS: F-18 fluorodeoxyglucose PET/CT as an imaging tool for staging and restaging cutaneous angiosarcoma of the scalp. Clin Nucl Med; 2006 Sep;31(9):534-7
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  • [Title] F-18 fluorodeoxyglucose PET/CT as an imaging tool for staging and restaging cutaneous angiosarcoma of the scalp.
  • Cutaneous angiosarcoma of the scalp is a rare highly aggressive malignant tumor that typically afflicts elderly patients and commonly presents with extensive local spread and distant metastasis.
  • Distant metastases favor lung, liver, lymph nodes, and skin.
  • We report the case of a 70-year-old man diagnosed with multifocal angiosarcoma of the scalp.
  • PET/CT imaging with F-18 2-fluoro-2-deoxyglucose (F-18 FDG) not only showed avid FDG uptake by an angiosarcoma (SUVmax = 10.7), but also simultaneously showed local extension of multifocal lesions with periosteal involvement and excluded metastatic abdominal nodal disease.
  • Evaluation of more cases of this subset of soft tissue sarcoma with FDG PET/CT may suggest a possible role in not only staging angiosarcomas to determine the extent of local as well as distant disease, but also to potentially help determine response to therapy and early recognition of local or distant recurrence.
  • [MeSH-major] Fluorodeoxyglucose F18. Hemangiosarcoma / diagnosis. Hemangiosarcoma / radionuclide imaging. Neoplasm Staging / methods. Positron-Emission Tomography / methods. Radiopharmaceuticals. Scalp / pathology. Skin Neoplasms / diagnosis. Skin Neoplasms / radionuclide imaging. Tomography, X-Ray Computed / methods

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  • (PMID = 16921276.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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49. Sherman M: Vinyl chloride and the liver. J Hepatol; 2009 Dec;51(6):1074-81
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  • [Title] Vinyl chloride and the liver.
  • Vinyl chloride monomer is a known cause of angiosarcoma of the liver.
  • It also has other toxic effects on the liver, and it has recently been suggested that exposure to vinyl chloride also causes hepatocellular carcinoma.
  • In the largest studies lack of data meant that confounding diseases such as viral hepatitis or alcoholic liver disease could not be assessed.
  • [MeSH-major] Liver / drug effects. Vinyl Chloride / toxicity
  • [MeSH-minor] Animals. Carcinoma, Hepatocellular / chemically induced. Hemangiosarcoma / chemically induced. Humans. Liver Cirrhosis / chemically induced. Liver Neoplasms / chemically induced. Mutagens / toxicity. Occupational Exposure. Risk Factors

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  • (PMID = 19836850.001).
  • [ISSN] 1600-0641
  • [Journal-full-title] Journal of hepatology
  • [ISO-abbreviation] J. Hepatol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Mutagens; WD06X94M2D / Vinyl Chloride
  • [Number-of-references] 50
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50. Kamo R, Ishina K, Hirata C, Doi K, Nakanishi T, Harada T, Ishii M: A case of ileoileal intussusception caused by metastatic pedunculated tumor of cutaneous angiosarcoma. J Dermatol; 2005 Aug;32(8):638-40
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  • [Title] A case of ileoileal intussusception caused by metastatic pedunculated tumor of cutaneous angiosarcoma.
  • Cutaneous angiosarcoma is a rare aggressive vascular tumor that occurs in elderly patients and is usually located on the head and face.
  • Metastases often develop in the cervical lymph nodes, lungs, bone, liver and spleen.
  • There have been no reports of ileoileal intussusception due to metastatic tumor from cutaneous angiosarcoma.
  • We reported a case of cutaneous angiosarcoma in a 67-year-old Japanese male accompanied with ileoileal intussusception due to metastatic angiosarcoma.
  • We assume that the metastatic tumor in the small intestine was metastasized hematogeneously from cutaneous angiosarcoma, resulting in the formation of nodules and the rapid growth of a pedunculated tumor as a forerunner of the ileoileal intessusception.
  • [MeSH-major] Hemangiosarcoma / diagnosis. Ileal Neoplasms / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Ileal Diseases / etiology. Intussusception / etiology. Male. Scalp

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  • (PMID = 16334863.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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51. Hamid KS, Rodriguez JA, Lairmore TC: Primary splenic angiosarcoma. JSLS; 2010 Jul-Sep;14(3):431-5
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  • [Title] Primary splenic angiosarcoma.
  • Primary splenic angiosarcoma is a rare, aggressive malignant neoplasm arising from splenic vascular endothelium.
  • Laparoscopic splenectomy was performed, and a primary splenic angiosarcoma was discovered.
  • After 2 rounds of chemotherapy, a CT scan showed progressive disease with metastasis to the liver and lung.
  • Primary splenic angiosarcoma is almost universally fatal despite treatment.
  • The best chance for survival is early diagnosis and prompt splenectomy prior to splenic rupture.

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  • (PMID = 21333203.001).
  • [ISSN] 1086-8089
  • [Journal-full-title] JSLS : Journal of the Society of Laparoendoscopic Surgeons
  • [ISO-abbreviation] JSLS
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3041046
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52. Kutara K, Asano K, Kito A, Teshima K, Kato Y, Sasaki Y, Edamura K, Shibuya H, Sato T, Hasegawa A, Tanaka S: Contrast harmonic imaging of canine hepatic tumors. J Vet Med Sci; 2006 May;68(5):433-8
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  • [Title] Contrast harmonic imaging of canine hepatic tumors.
  • Six adult healthy Beagles were used to investigate the hepatic perfusion dynamics of Levovist, a contrast agent used in contrast harmonic imaging (CHI).
  • In addition, 8 dogs with hepatocellular carcinoma (HCC) and 2 dogs with metastatic hepatic hemangiosarcoma (HSA) were used to characterize both the CHI findings with Levovist.
  • In the Beagles, the start of intravenously injected Levovist into the aorta between the cranial mesenteric and renal arteries and the portal vein at the hepatic hilum were 5.47 +/- 1.52 sec and 16.03 +/- 3.39 sec, respectively.
  • As a characteristic CHI finding in the 8 dogs with HCC, the early arterial phase showed a fine network of blood flow enhanced at the surrounding region and within the tumor in all the 8 dogs (100%), and the post vascular phase demonstrated a defect in the whole tumor and an enhancement of the surrounding hepatic tissues in 7 dogs (87.5%).
  • In the 2 dogs with HSA, characteristic finding in which the early arterial and late vascular phases showed a rim contrast enhancement pattern, and the post vascular phase revealed that the whole tumor lacked contrast enhancement and the surrounding hepatic tissues was clearly enhanced.
  • Therefore, CHI is thought to be useful for the diagnosis of HCC and metastatic hepatic HSA in dogs as well as in humans.

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  • (PMID = 16757885.001).
  • [ISSN] 0916-7250
  • [Journal-full-title] The Journal of veterinary medical science
  • [ISO-abbreviation] J. Vet. Med. Sci.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Polysaccharides; 127279-08-7 / SHU 508
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53. Wang ZS, Wang WX, Xiong CL, Zhan N, Li H: Spontaneous ruptured primary hepatic angiosarcoma coincident with Schistosoma Japonica liver fibrosis. Hepatol Res; 2007 Jul;37(7):572-6
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  • [Title] Spontaneous ruptured primary hepatic angiosarcoma coincident with Schistosoma Japonica liver fibrosis.
  • AIM: We report herein a case of spontaneous ruptured primary hepatic angiosarcoma coincident with Schistosoma Japonica liver fibrosis and review the correlative literature.
  • RESULTS: The final diagnosis was spontaneous ruptured primary hepatic angiosarcoma coincident with Schistosoma Japonica liver fibrosis Conclusion: Considering the nature of primary hepatic angiosarcoma, in particular the ruptured hepatic angiosarcoma, it is obviously desirable to avoid any unnecessary delay or definitive surgical treatment.
  • It is presumed that angiosarcoma in the liver has a possible association with S. japonicum and the deposition of ovae in liver.

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  • (PMID = 17540001.001).
  • [ISSN] 1386-6346
  • [Journal-full-title] Hepatology research : the official journal of the Japan Society of Hepatology
  • [ISO-abbreviation] Hepatol. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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54. Husted TL, Neff G, Thomas MJ, Gross TG, Woodle ES, Buell JF: Liver transplantation for primary or metastatic sarcoma to the liver. Am J Transplant; 2006 Feb;6(2):392-7
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  • [Title] Liver transplantation for primary or metastatic sarcoma to the liver.
  • Sarcoma is generally a rare disease in the US, with poor survival in patients with both primary angiosarcoma and metastatic disease from sarcoma and GIST.
  • In order to determine if liver transplantation for sarcoma is a realistic option, we examined records of all patients in the US component of the Israel Penn International Transplant Tumor Registry were reviewed.
  • Those patients with liver failure from primary or metastatic liver sarcoma were evaluated.
  • 19 patients are identified having received liver transplantation after treatment for sarcoma of the liver, 6 patients with primary hepatic sarcoma and 13 patients with metastatic sarcoma of the liver.
  • Given the early recurrence of tumor and meager 1-year survival outcome, liver transplantation is a poor therapeutic choice for patients with either primary or metastatic liver sarcoma, including high-grade leiomyosarcoma (GIST) regardless of primary site or primary therapy.
  • [MeSH-major] Liver Neoplasms / surgery. Liver Transplantation. Sarcoma / surgery


55. Castro EC, Galambos C, Shaw PH, Ranganathan S: Primary mesenteric angiosarcoma in a child with associated lymphangiectasia: a case report. Pediatr Dev Pathol; 2008 Nov-Dec;11(6):482-6
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  • [Title] Primary mesenteric angiosarcoma in a child with associated lymphangiectasia: a case report.
  • Angiosarcomas are rare tumors in children, usually occurring in soft tissue and liver.
  • By contrast, angiosarcoma in adults usually occurs in the extremities in conjunction with lymphedema.
  • Mesenteric angiosarcoma has only rarely been reported.
  • When angiosarcomas arise in this location, they usually represent a 2nd malignancy following Hodgkin's lymphoma.
  • We report a child who presented to the emergency room with an acute abdomen and underwent emergency surgery for a mesenteric angiosarcoma with associated lymphangiectasia of the bowel and mesentery.
  • [MeSH-major] Hemangiosarcoma / secondary. Lymphangiectasis, Intestinal / pathology. Peritoneal Neoplasms / pathology

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  • (PMID = 19143455.001).
  • [ISSN] 1093-5266
  • [Journal-full-title] Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
  • [ISO-abbreviation] Pediatr. Dev. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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56. Li Q, Wang J, Sun Y, Cui Y, Hao X: Hepatic angiosarcoma arising in an adult mesenchymal hamartoma. Int Semin Surg Oncol; 2007;4:3
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  • [Title] Hepatic angiosarcoma arising in an adult mesenchymal hamartoma.
  • The histogenesis of the hepatic sarcoma and its association with hamartoma is not well understood.
  • We hereby present a Chinese patient with hepatic angiosarcoma arising from an adult mesenchymal hamartoma of liver.
  • A 33-yr-old woman was diagnosed hepatic hamartoma eight years ago and presented with epigastric distention recently.
  • Now she was admitted to our hospital with some unusual features: (a) this patient was diagnosed in mid-twenties, (b) the tumor occupied the whole liver and most importantly (c) the hepatic angiosarcoma appeared 8 years after the diagnosis of hamartoma.
  • Based on this case and some reports, hepatic hamartoma may develop to hepatic angiosarcoma.

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  • [Cites] Mod Pathol. 1994 May;7(4):490-3 [8066077.001]
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  • (PMID = 17257403.001).
  • [ISSN] 1477-7800
  • [Journal-full-title] International seminars in surgical oncology : ISSO
  • [ISO-abbreviation] Int Semin Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1796548
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57. Nakamura M, Tsushima K, Yasuo M, Yamazaki Y, Honda T, Koizumi T, Fujimoto K, Kubo K: Angiosarcoma with sacral origin metastasizing to the lung. Intern Med; 2006;45(15):923-6
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  • [Title] Angiosarcoma with sacral origin metastasizing to the lung.
  • Specimens obtained by video-assisted thoracic surgery revealed angiosarcoma, but the primary site of angiosarcoma could not be detected before autopsy.
  • Angiosarcoma is a rare malignant neoplasm with rapid proliferation and they can arise at any region of the body.
  • It can originate in the skin, soft tissue, liver or heart.
  • Their multicentric and local recurrence easily leads us to misdiagnosis, and we have struggled to reach diagnosis and its origin.
  • Angiosarcoma should be included in the different diagnosis of diffuse pulmonary hemorrhage with multiple lung nodules.
  • [MeSH-major] Hemangiosarcoma / diagnosis. Lung Neoplasms / diagnosis. Lung Neoplasms / secondary. Sacrum / pathology. Spinal Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Male

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  • (PMID = 16946576.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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58. Chuang SC, La Vecchia C, Boffetta P: Liver cancer: descriptive epidemiology and risk factors other than HBV and HCV infection. Cancer Lett; 2009 Dec 1;286(1):9-14
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  • [Title] Liver cancer: descriptive epidemiology and risk factors other than HBV and HCV infection.
  • The incidence of liver cancer is high in all low-resource regions of the world, with the exception of Northern Africa and Western Asia.
  • The estimated worldwide number of new cases of liver cancer in 2002 is 600,000, of which 82% are from developing countries.
  • Hepatocellular carcinoma (HCC) is the main form of liver cancer.
  • The second most important type of liver cancer is cholangiocarcinoma, whose main known cause is infestation with the liver flukes, Opistorchis viverrini and Clonorchis sinensis, which is frequent in some areas in South-East Asia.
  • Angiosarcoma is a rare form of liver cancer whose occurence is linked to occupational exposure to vinyl chloride.
  • [MeSH-major] Carcinoma, Hepatocellular / epidemiology. Liver Neoplasms / epidemiology

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  • (PMID = 19091458.001).
  • [ISSN] 1872-7980
  • [Journal-full-title] Cancer letters
  • [ISO-abbreviation] Cancer Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Aflatoxins; 0 / Contraceptives, Oral
  • [Number-of-references] 48
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59. Suzuki H, Komatsu A, Fujioka Y, Yamashiro K, Takeda H, Hamada T: Angiosarcoma-like metastatic carcinoma of the liver. Pathol Res Pract; 2010 Jul 15;206(7):484-8
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  • [Title] Angiosarcoma-like metastatic carcinoma of the liver.
  • Two cases of metastatic carcinoma strikingly simulating angiosarcoma in the liver are described.
  • The first case was a 53-year-old female with cystic liver tumors which were found 22 months after surgery for ureteral cancer.
  • The second case was an 81-year-old female with multiple tumors in the liver and the pancreas, and a post-mortem examination was carried out.
  • Both cases had an angiosarcoma-like appearance macroscopically and microscopically.
  • Immunohistochemically, the tumor cells of both cases were negative for CD31, CD34, and Factor VIII-related antigen and positive for several types of cytokeratin, suggesting that they were not angiosarcomas but carcinomas.
  • Angiosarcoma is the most common sarcoma arising in the liver.
  • Thus, metastatic carcinoma, which resembles angiosarcoma, might be mistaken for angiosarcoma.
  • [MeSH-major] Carcinoma / secondary. Liver Neoplasms / secondary. Skin Neoplasms / pathology. Ureteral Neoplasms / pathology
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. Female. Hemangiosarcoma / pathology. Humans. Immunohistochemistry. Middle Aged

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  • [Copyright] Copyright 2009 Elsevier GmbH. All rights reserved.
  • (PMID = 20097483.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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60. Yoshida K, Ito F, Nakazawa H, Maeda Y, Tomoe H, Aiba M: A case of primary renal angiosarcoma. Rare Tumors; 2009;1(2):e28
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  • [Title] A case of primary renal angiosarcoma.
  • Serial CT scans revealed the left kidney mass to be increasing in size and a new lesion in the liver.
  • Renal cell carcinoma with liver metastasis was diagnosed and a radical nephrectomy performed.
  • The initial pathological diagnosis was a benign chronic hematoma.
  • However, the liver mass increased in size and multiplied, while another mass emerged in the twelfth thoracic vertebra with spinal paralysis and was immediately removed.
  • The renal specimen was re-evaluated using whole cross-section analysis and immunohistochemistry, and diagnosed as a primary renal angiosarcoma.
  • Although contrast imaging depicted the primary lesion as a non-specific hematoma with little focal pooling, and low-grade cytological atypia was shown pathologically, the angiosarcoma was extremely aggressive.

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  • (PMID = 21139907.001).
  • [ISSN] 2036-3613
  • [Journal-full-title] Rare tumors
  • [ISO-abbreviation] Rare Tumors
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2994470
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61. Spiess PE, Kassouf W, Steinberg JR, Tuziak T, Hernandez M, Tibbs RF, Czerniak B, Kamat AM, Dinney CP, Grossman HB: Review of the M.D. Anderson experience in the treatment of bladder sarcoma. Urol Oncol; 2007 Jan-Feb;25(1):38-45
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  • METHODS: Between January 1985 and July 2004, 19 patients (12 men and 7 women) with primary bladder sarcoma were evaluated at the University of Texas M.D.
  • The histologic subtypes of bladder sarcoma were leiomyosarcoma (N = 14), angiosarcoma (N = 3), and unclassified sarcoma (N = 2).
  • The primary treatment modalities used were surgery in 16 (84%) patients, chemotherapy in 2 (11%), and palliation in 1 (5%).
  • The most common sites of distant metastases were the lungs, bone, brain, and liver.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / epidemiology. Neoplasm Staging. Prognosis. Retrospective Studies

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  • (PMID = 17208137.001).
  • [ISSN] 1078-1439
  • [Journal-full-title] Urologic oncology
  • [ISO-abbreviation] Urol. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA91846
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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62. Maeda T, Tateishi U, Hasegawa T, Ojima H, Arai Y, Sugimura K: Primary hepatic angiosarcoma on coregistered FDG PET and CT images. AJR Am J Roentgenol; 2007 Jun;188(6):1615-7
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  • [Title] Primary hepatic angiosarcoma on coregistered FDG PET and CT images.
  • [MeSH-major] Fluorodeoxyglucose F18. Hemangiosarcoma / radiography. Liver Neoplasms / radiography. Positron-Emission Tomography / methods. Subtraction Technique. Tomography, X-Ray Computed / methods

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  • (PMID = 17515384.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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63. Odashiro AN, Pereira PR, Odashiro Miiji LN, Nguyen GK: Angiosarcoma of the gallbladder: case report and review of the literature. Can J Gastroenterol; 2005 Apr;19(4):257-9
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  • [Title] Angiosarcoma of the gallbladder: case report and review of the literature.
  • At autopsy, an angiosarcoma measuring 5 cm in diameter was found in the liver, at the site of the gallbladder fossa.
  • There were multiple hepatic, splenic, ovarian and peritoneal metastases and a massive hemoperitoneum consisting of 8 L of blood and blood clots.
  • Review of the tissue sections from the patient's gallbladder confirmed the presence of an acute hemorrhagic and chronic cholecystitis and also revealed residual foci of an angiosarcoma.
  • A review of eight previously reported cases of gallbladder angiosarcoma is also presented.
  • [MeSH-major] Gallbladder Neoplasms / diagnosis. Hemangiosarcoma / diagnosis
  • [MeSH-minor] Cholecystectomy. Cholecystitis / diagnosis. Cholelithiasis / diagnosis. Fatal Outcome. Female. Hemoperitoneum / etiology. Humans. Middle Aged. Postoperative Complications

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  • (PMID = 15861270.001).
  • [ISSN] 0835-7900
  • [Journal-full-title] Canadian journal of gastroenterology = Journal canadien de gastroenterologie
  • [ISO-abbreviation] Can. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Canada
  • [Number-of-references] 11
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64. Wang XY, Jakowski J, Tawfik OW, Thomas PA, Fan F: Angiosarcoma of the breast: a clinicopathologic analysis of cases from the last 10 years. Ann Diagn Pathol; 2009 Jun;13(3):147-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma of the breast: a clinicopathologic analysis of cases from the last 10 years.
  • Breast angiosarcoma may occur de novo, or as a complication of radiation therapy, or chronic lymphedema secondary to axillary lymph node dissection for mammary carcinoma.
  • In our effort to characterize the clinicopathologic features of breast angiosarcoma, we reviewed all breast angiosarcoma cases in the University of Kansas Medical Center and Ohio State University Medical Center archives from 1997 to 2007.
  • Only 11 angiosarcomas were identified among more than 5000 malignant breast neoplasms (0.1%-0.2% incidence) for the last 10 years.
  • Eight cases (6 high grade, 1 intermediate grade, 1 low grade) were identified as postradiation angiosarcoma (postradiation time interval, 4-12 years), and 3 cases were identified as primary angiosarcomas (1 high grade, 2 low grade).
  • Follow-up (median, 36 months) revealed that 3 cases of postradiation angiosarcoma recurred as skin and/or chest wall lesions and 1 case of primary angiosarcoma developed liver metastases (all high-grade).
  • In conclusion, breast angiosarcoma remains a rare disease.
  • Rosen's method for grading breast angiosarcoma is easy to implement and correlates well with clinical outcome.
  • There are no distinct clinical or histologic differences between primary and postradiation breast angiosarcomas.
  • [MeSH-major] Breast Neoplasms / pathology. Hemangiosarcoma / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Chemotherapy, Adjuvant. Combined Modality Therapy. Female. Humans. Mastectomy. Middle Aged. Neoplasm Recurrence, Local / epidemiology. Neoplasms, Radiation-Induced / pathology. Neoplasms, Radiation-Induced / therapy

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  • (PMID = 19433291.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 12
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65. Burns CJ, Jammer BL, Bodnar CM: Mortality rates among chemical workers in the Kanawha Valley of West Virginia: 1940-1999. W V Med J; 2006 Jul-Aug;102(4):24-8
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  • We observed no new cases of angiosarcoma of the liver, a cause of death previously reported in association with vinyl chloride production at the South Charleston location.
  • [MeSH-minor] Adult. Aged. Carcinogens, Environmental / adverse effects. Cause of Death. Cohort Studies. Employment. Female. Follow-Up Studies. Healthy Worker Effect. Hemangiosarcoma / chemically induced. Hemangiosarcoma / mortality. Humans. Liver Neoplasms / chemically induced. Liver Neoplasms / mortality. Lymphoma, Large B-Cell, Diffuse / chemically induced. Lymphoma, Large B-Cell, Diffuse / mortality. Lymphoma, Non-Hodgkin / chemically induced. Lymphoma, Non-Hodgkin / mortality. Male. Middle Aged. Risk. Risk Factors. Sex Factors. Time Factors. Vinyl Chloride / adverse effects. West Virginia

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  • [CommentIn] W V Med J. 2006 Sep-Oct;102(5):5 [17285946.001]
  • (PMID = 17111678.001).
  • [ISSN] 0043-3284
  • [Journal-full-title] The West Virginia medical journal
  • [ISO-abbreviation] W V Med J
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens, Environmental; WD06X94M2D / Vinyl Chloride
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66. Zhou YM, Li B, Yin ZM, Xu F, Wang B, Xu W, Liu P, Yang JM: Results of hepatic resection for primary hepatic angiosarcoma in adults. Med Sci Monit; 2010 Feb;16(2):CR61-6
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  • [Title] Results of hepatic resection for primary hepatic angiosarcoma in adults.
  • BACKGROUND: Primary hepatic angiosarcoma is an uncommon but aggressive malignancy with poor prognosis.
  • MATERIAL/METHODS: Medical records of 6 patients who underwent surgical resection for primary hepatic angiosarcoma at our institution between 1998 and 2006 were reviewed retrospectively.
  • The most common symptoms at diagnosis were pain in the right upper quadrant, abdominal distension, weakness and weight loss.
  • CONCLUSIONS: Although the overall outcome of surgical resection remains unsatisfactory, complete surgical resection may prolong survival of patients with solitary primary hepatic angiosarcoma without spontaneous rupture.
  • [MeSH-major] Hemangiosarcoma / surgery. Liver Neoplasms / surgery

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  • (PMID = 20110916.001).
  • [ISSN] 1643-3750
  • [Journal-full-title] Medical science monitor : international medical journal of experimental and clinical research
  • [ISO-abbreviation] Med. Sci. Monit.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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67. Mayer F, Aebert H, Rudert M, Königsrainer A, Horger M, Kanz L, Bamberg M, Ziemer G, Hartmann JT: Primary malignant sarcomas of the heart and great vessels in adult patients--a single-center experience. Oncologist; 2007 Sep;12(9):1134-42
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  • [Title] Primary malignant sarcomas of the heart and great vessels in adult patients--a single-center experience.
  • METHODS: Between January 1993 and September 2006, of 1,429 patients registered to the Sarcoma Center, 14 had a primary sarcoma of the heart or large vessels.
  • The most frequently encountered histologic subtypes were leiomyosarcoma and angiosarcoma.
  • Six patients presented with distant metastases to the lungs (n = 5), lymph nodes (n = 2), and liver (n = 1).
  • After a median follow-up of 14.5 months (range, 2-156), three patients were alive with no evidence of disease 11, 52, and 156 months after diagnosis.
  • CONCLUSIONS: Patients with primary sarcomas of the heart and the large vessels were of a young age, and more than half of them presented with advanced disease.
  • [MeSH-minor] Adult. Aortic Diseases / epidemiology. Female. Follow-Up Studies. Germany / epidemiology. Hemangiosarcoma / epidemiology. Humans. Leiomyosarcoma / epidemiology. Lung Neoplasms / secondary. Lymphatic Metastasis. Male. Middle Aged. Neoadjuvant Therapy / statistics & numerical data. Pulmonary Artery / pathology. Remission Induction. Retrospective Studies. Survival Rate. Venae Cavae / pathology

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  • (PMID = 17914083.001).
  • [ISSN] 1083-7159
  • [Journal-full-title] The oncologist
  • [ISO-abbreviation] Oncologist
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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68. Maluf D, Cotterell A, Clark B, Stravitz T, Kauffman HM, Fisher RA: Hepatic angiosarcoma and liver transplantation: case report and literature review. Transplant Proc; 2005 Jun;37(5):2195-9
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  • [Title] Hepatic angiosarcoma and liver transplantation: case report and literature review.
  • Hepatic angiosarcoma is a rare malignant vascular tumor that accounts for up to 2% of all primary liver tumors.
  • Accurate diagnosis of this tumor is difficult, especially if the patient has no history of exposure to specific carcinogens including thorotrast, arsenicals, and vinyl chloride monomer.
  • Diagnosis of diffuse angiosarcoma by means of liver biopsy has been reported as treacherous and nondiagnostic.
  • Herein, we present a case of a 61-year-old Caucasian male with history of cryptogenic cirrhosis, normal alpha-fetoprotein, and pretransplant abnormal liver MRI who underwent nondiagnostic liver biopsies followed by liver transplantation.
  • High grade diffuse angiosarcoma was diagnosed in the explanted liver.
  • Diffuse liver tissue infiltration seen pretransplant on CT scan or MRI, suggesting the possibility of diffuse liver lesions (HCC, angiosarcoma, etc) must be fully investigated with all techniques available including multiple open liver biopsies to avoid the sacrifice of a liver allograft in these patients.
  • [MeSH-major] Hemangiosarcoma / pathology. Hemangiosarcoma / surgery. Liver Neoplasms / pathology. Liver Neoplasms / surgery. Liver Transplantation

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  • (PMID = 15964377.001).
  • [ISSN] 0041-1345
  • [Journal-full-title] Transplantation proceedings
  • [ISO-abbreviation] Transplant. Proc.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 17
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69. Mignogna C, Simonetti S, Galloro G, Magno L, De Cecio R, Insabato L: Duodenal epithelioid angiosarcoma: immunohistochemical and clinical findings. A case report. Tumori; 2007 Nov-Dec;93(6):619-21
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  • [Title] Duodenal epithelioid angiosarcoma: immunohistochemical and clinical findings. A case report.
  • Angiosarcomas are uncommon malignant tumors of vascular endothelium that represent less than 1% of all sarcomas.
  • The epithelioid variant of angiosarcomas is exceptionally rare, and the gastrointestinal tract is rarely involved.
  • Angiosarcomas mainly involve skin and soft tissue and rarely occur in breast, liver, bone, and spleen.
  • A duodenal reddish polypoid lesion was found, which on microscopic examination turned out to be an epithelioid angiosarcoma.
  • The immunohistochemical features of the lesion supported this diagnosis.
  • The patient died eight months after the diagnosis.
  • Epithelioid angiosarcoma is an aggressive variant of angiosarcoma and must be considered in the differential diagnosis of gastrointestinal tumors.
  • [MeSH-major] Duodenal Neoplasms / pathology. Hemangioendothelioma, Epithelioid / pathology. Hemangiosarcoma / pathology

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  • (PMID = 18338501.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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70. Catalano O, Sandomenico F, Raso MM, Siani A: Real-time, contrast-enhanced sonography: a new tool for detecting active bleeding. J Trauma; 2005 Oct;59(4):933-9
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  • These included spleen injury (n = 8), liver injury (n = 3), kidney injury (n = 1), abdominal aortic aneurysm rupture (n = 5), splenic angiosarcoma rupture (n = 1), postsurgical bleeding after abdominal aortic aneurysm repair (n = 1), and postsplenectomy bleeding (n = 1).

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  • (PMID = 16374284.001).
  • [ISSN] 0022-5282
  • [Journal-full-title] The Journal of trauma
  • [ISO-abbreviation] J Trauma
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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71. García-Botella A, Díez-Valladares L, Martín-Antona E, Sánchez-Pernaute A, Pérez-Aguirre E, Ortega L, Rodríguez R, Balibrea JL: Epithelioid hemangioendothelioma of the liver. J Hepatobiliary Pancreat Surg; 2006;13(2):167-71
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  • [Title] Epithelioid hemangioendothelioma of the liver.
  • Epithelioid hemangioendothelioma (EH) is a rare tumor of vascular origin, which occurs at sites such as soft tissues, liver, or lung, and has a highly unpredictable malignant potential.
  • It is an intermediate entity between well-differentiated hemangioma and angiosarcoma.
  • We present two cases of this rare disease in which the tumor was detected fortuitously and the definitive diagnosis was based on histological evidence.
  • Both our cases are highly illustrative of the two ways in which hepatic EH can present (nodular or diffuse) and of its diagnostic and therapeutic management.
  • Treatment was surgical resection in one patient and liver transplant in the other.
  • Although EH of the liver has a better prognosis than other hepatic neoplasms, conservative treatment is not recommended.
  • Our cases highlight the importance of a histological diagnosis to avoid it being mistaken for another entity.
  • [MeSH-major] Hemangioendothelioma, Epithelioid / pathology. Hemangioendothelioma, Epithelioid / surgery. Liver Neoplasms / pathology. Liver Neoplasms / surgery. Liver Transplantation
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Middle Aged


72. Heo SH, Jeong YY, Shin SS, Chung TW, Kang HK: Solitary small hepatic angiosarcoma: initial and follow-up imaging findings. Korean J Radiol; 2007 Mar-Apr;8(2):180-3
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  • [Title] Solitary small hepatic angiosarcoma: initial and follow-up imaging findings.
  • We report an uncommon case of solitary, small hepatic angiosarcoma that was initially considered as a hemangioma.
  • We present the imaging findings, with an emphasis on the initial and follow-up CT and MR findings, as well as report on the more suggestive findings of angiosarcoma than those of a hemangioma.
  • [MeSH-major] Hemangiosarcoma / diagnosis. Liver Neoplasms / diagnosis
  • [MeSH-minor] Contrast Media. Diagnosis, Differential. Gadolinium DTPA. Hemangioma / diagnosis. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 17420638.001).
  • [ISSN] 1229-6929
  • [Journal-full-title] Korean journal of radiology
  • [ISO-abbreviation] Korean J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Contrast Media; K2I13DR72L / Gadolinium DTPA
  • [Other-IDs] NLM/ PMC2626776
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73. Lee SW, Song CY, Gi YH, Kang SB, Kim YS, Nam SW, Lee DS, Kim JO: Hepatic angiosarcoma manifested as recurrent hemoperitoneum. World J Gastroenterol; 2008 May 14;14(18):2935-8
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  • [Title] Hepatic angiosarcoma manifested as recurrent hemoperitoneum.
  • Angiosarcoma is a rare tumor that account for less than 1% of all sarcomas.
  • Although hepatic angiosarcoma usually presents with unspecific symptoms, it rapidly progresses and has a high mortality.
  • We report a rare case of primary hepatic angiosarcoma manifested as recurrent hemoperitoneum.
  • [MeSH-major] Hemangiosarcoma / complications. Hemoperitoneum / diagnosis. Hemoperitoneum / etiology. Liver Neoplasms / complications

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  • (PMID = 18473427.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2710744
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74. Lin CF, DeFrias D, Lin X: Epithelioid angiosarcoma: a neoplasm with potential diagnostic challenges. Diagn Cytopathol; 2010 Feb;38(2):154-8
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  • [Title] Epithelioid angiosarcoma: a neoplasm with potential diagnostic challenges.
  • Epithelioid angiosarcomas are extremely rare tumors associated with poor prognosis and early metastases.
  • In this report, the patient is a 24-year-old man presenting with testicular pain, a pelvic mass, and innumerable liver nodules.
  • Immediate interpretation of the needle core biopsies of the pelvic mass and liver lesions initially favored a poorly differentiated adenocarcinoma.
  • Further, immunohistochemical evaluation demonstrated positive CD31 and Factor VIII staining and established the final diagnosis of epithelioid angiosarcoma.
  • This case is reported to illustrate the importance of considering the diagnosis of epithelioid angiosarcoma when encountering an "epithelioid" neoplasm particularly with unusual immunoreactivity for CK7 and CD30.
  • [MeSH-minor] Adenocarcinoma / pathology. Diagnosis, Differential. Humans. Immunohistochemistry. Liver Neoplasms / secondary. Male. Young Adult

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  • (PMID = 19813270.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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75. Beland FA, Benson RW, Mellick PW, Kovatch RM, Roberts DW, Fang JL, Doerge DR: Effect of ethanol on the tumorigenicity of urethane (ethyl carbamate) in B6C3F1 mice. Food Chem Toxicol; 2005 Jan;43(1):1-19
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  • Hepatic levels of the DNA adduct 1,N(6)-ethenodeoxyadenosine were increased by exposure to urethane and decreased by treatment with ethanol.
  • Urethane caused dose-dependent increases in liver, lung, and harderian gland adenoma or carcinoma and hemangiosarcoma of the liver and heart in both sexes, mammary gland and ovarian tumors in females, and squamous cell papilloma or carcinoma of the skin and forestomach in males.
  • The increase in hepatocellular tumors occurred in a relatively linear manner and was attributed to the formation of 1,N(6)-ethenodeoxyadenosine in hepatic DNA coupled with an increase in cell replication.
  • In female mice administered 10 ppm and 90 ppm urethane, ethanol caused dose-related increases in alveolar/bronchiolar adenoma or carcinoma and hemangiosarcoma of the heart, respectively.
  • [MeSH-minor] Animals. Apoptosis / drug effects. Body Weight / drug effects. Carcinogenicity Tests. Cell Division / drug effects. Cytochrome P-450 Enzyme System / metabolism. DNA Adducts. Dose-Response Relationship, Drug. Female. Liver / drug effects. Liver / enzymology. Liver / pathology. Lung / drug effects. Lung / pathology. Male. Mice. Mice, Inbred Strains. Random Allocation. Sex Factors. Survival Analysis

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  • (PMID = 15582191.001).
  • [ISSN] 0278-6915
  • [Journal-full-title] Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • [ISO-abbreviation] Food Chem. Toxicol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Carcinogens; 0 / DNA Adducts; 3IN71E75Z5 / Urethane; 3K9958V90M / Ethanol; 9035-51-2 / Cytochrome P-450 Enzyme System
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76. Yamamoto Y, Chikawa J, Uegaki Y, Usuda N, Kuwahara Y, Fukumoto M: Histological type of Thorotrast-induced liver tumors associated with the translocation of deposited radionuclides. Cancer Sci; 2010 Feb;101(2):336-40
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  • [Title] Histological type of Thorotrast-induced liver tumors associated with the translocation of deposited radionuclides.
  • Exposure to internally deposited radionuclides is known to induce malignant tumors of various histological types.
  • Thorotrast is known to induce liver tumors, particularly intrahepatic cholangiocarcinoma (ICC) and angiosarcoma (AS), decades after injection.
  • Autoradiography and X-ray fluorescence spectrometry (XRF) were carried out on non-tumorous liver sections from Thorotrast-induced ICC (T-ICC) and Thorotrast-induced AS (T-AS).
  • Autoradiography revealed that the slope of the regression line of the number of alpha tracks for the amount of deposited Thorium ((232)Th) was higher in non-tumorous parts of the liver with T-ICC than those with T-AS.
  • XRF showed that the intensity ratio of Radium (Ra) to Thorium (Th) in non-tumorous liver tissue with T-ICC was significantly higher than that with T-AS.
  • These suggest that the metabolic behavior of radionuclides such as relocation and excretion, as well as the content of deposited radionuclides, is a major factor in determining the histological type of Thorotrast-induced liver tumors.
  • [MeSH-major] Liver Neoplasms / etiology. Radium / pharmacokinetics. Thorium / pharmacokinetics. Thorium Dioxide / adverse effects
  • [MeSH-minor] Adult. Alpha Particles. Autoradiography. Biological Transport. Humans. Liver / metabolism. Radiation Dosage. Spectrometry, X-Ray Emission

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  • (PMID = 19917057.001).
  • [ISSN] 1349-7006
  • [Journal-full-title] Cancer science
  • [ISO-abbreviation] Cancer Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 60YU5MIG9W / Thorium; 9XA7X17UQC / Thorium Dioxide; W90AYD6R3Q / Radium
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77. Kahraman A, Miller M, Baba H, Gerken G, Hilgard P: [Angiosarcoma of the liver as a rare cause of rapidly progressive liver failure]. Med Klin (Munich); 2006 Sep 15;101(9):746-50
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  • [Title] [Angiosarcoma of the liver as a rare cause of rapidly progressive liver failure].
  • [Transliterated title] Angiosarkom der Leber als seltene Ursache eines rasch progredienten Leberversagens.
  • BACKGROUND: Angiosarcoma of the liver is a rare, highly malignant and sometimes diffusely infiltrating vessel tumor with rapid progression and poor prognosis.
  • CASE REPORT: A 46-year-old male patient with rapidly progressive liver failure, initially regarded as decompensation of known alcoholic liver cirrhosis, is reported.
  • The patient was referred to the authors' center for evaluation of liver transplantation, but a massive weight loss despite long absence of any alcohol intake raised the suspicion of a malignant disease.
  • A following MRI demonstrated diffuse focal contrast enhancement in the entire liver parenchyma, confirming diffuse infiltration of the organ by a malignant tumor.
  • Sonographically guided percutaneous liver biopsy established the diagnosis of a malignant vascular tumor with diffuse infiltration of the liver parenchyma.
  • Macroscopic examination of the liver during autopsy showed multiple lacunae filled with blood.
  • Therefore, the differential diagnosis of a peliosis hepatis was raised.
  • However, histology confirmed the diagnosis of a malignant angiosarcoma with diffuse osseous metastases.
  • CONCLUSION: A diffuse infiltration of the liver by an angiosarcoma in the absence of any definite lesions may lead to a substantial delay of the diagnosis.
  • The only relevant differential diagnosis in this case is the equally rare peliosis hepatis.
  • [MeSH-major] Hemangiosarcoma / diagnosis. Liver Failure / etiology. Liver Neoplasms / diagnosis
  • [MeSH-minor] Biopsy. Bone Neoplasms / diagnosis. Bone Neoplasms / pathology. Bone Neoplasms / secondary. Diagnosis, Differential. Disease Progression. Esophageal and Gastric Varices / pathology. Fatal Outcome. Gastrointestinal Hemorrhage / pathology. Humans. Liver / pathology. Liver Cirrhosis, Alcoholic / diagnosis. Liver Cirrhosis, Alcoholic / pathology. Magnetic Resonance Imaging. Male. Middle Aged. Peliosis Hepatis / diagnosis. Peliosis Hepatis / pathology

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  • (PMID = 16977400.001).
  • [ISSN] 0723-5003
  • [Journal-full-title] Medizinische Klinik (Munich, Germany : 1983)
  • [ISO-abbreviation] Med. Klin. (Munich)
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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78. Luk A, Nwachukwu H, Lim KD, Cusimano RJ, Butany J: Cardiac angiosarcoma: a case report and review of the literature. Cardiovasc Pathol; 2010 May-Jun;19(3):e69-74
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  • [Title] Cardiac angiosarcoma: a case report and review of the literature.
  • We present the case of a 36-year-old woman with widespread metastatic cardiac angiosarcoma to the lungs and the liver.
  • [MeSH-major] Heart Neoplasms / pathology. Hemangiosarcoma / secondary
  • [MeSH-minor] Adult. Antineoplastic Agents / therapeutic use. Cardiovascular Surgical Procedures. Combined Modality Therapy. Female. Humans. Liver Neoplasms / secondary. Liver Neoplasms / therapy. Lung Neoplasms / secondary. Lung Neoplasms / therapy. Neoadjuvant Therapy

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 19150248.001).
  • [ISSN] 1879-1336
  • [Journal-full-title] Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology
  • [ISO-abbreviation] Cardiovasc. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 34
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79. Ishibashi N, Mitachi Y, Sugawara S, Shinozaki S, Miura M, Fukuju T, Katahira Y, Koyama K, Fujikawa N, Kato T, Murakami K: [A case of cardiac angiosarcoma successfully treated with docetaxel]. Gan To Kagaku Ryoho; 2007 Nov;34(11):1849-52
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  • [Title] [A case of cardiac angiosarcoma successfully treated with docetaxel].
  • We report a case of angiosarcoma of the right atrium presenting superior vena cava syndrome.
  • The pathological diagnosis was angiosarcoma.
  • The patient agreed to chemotherapy with docetaxel, which is known to be often effective against angiosarcoma of the scalp or face.
  • The tumor, however, became resistant to docetaxel and formed metastatic involvements in the liver.
  • Following treatments with paclitaxel, IL-2 and CPT-11 were ineffective for the primary tumor and liver metastases.
  • He had long-term survival 31 months after the diagnosis.
  • An effective treatment for cardiac angiosarcoma has not yet been established.
  • Chemotherapy with docetaxel should be considered in the treatment of patients with cardiac angiosarcoma.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Heart Neoplasms / drug therapy. Hemangiosarcoma / drug therapy. Taxoids / therapeutic use
  • [MeSH-minor] Drug Administration Routes. Drug Resistance, Neoplasm. Heart Atria. Humans. Liver Neoplasms / secondary. Male. Middle Aged

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  • (PMID = 18030022.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Taxoids; 15H5577CQD / docetaxel
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80. Hoti E, Adam R: Liver transplantation for primary and metastatic liver cancers. Transpl Int; 2008 Dec;21(12):1107-17
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Liver transplantation for primary and metastatic liver cancers.
  • Liver transplantation for hepatic malignancies has emerged as a well-documented and proven treatment modality.
  • Currently, 15% of all liver transplants performed are for hepatocellular carcinoma (HCC).
  • There is no controversy about the fact that liver transplantation for HCC in the adult population yields good results for patients whose tumour masses do not exceed the Milan criteria.
  • In patients with small HCC at an early stage and preserved liver function, liver resection provides an alternative to transplant.
  • Liver resection may offer similar survival results to orthotopic liver transplantation (OLT) in the short term, and does not carry the long-term effects of immunosuppression; however, long-term and disease-free survival favours liver transplantation.
  • Survival rate in these selected patients can approach that of patients with cholestatic liver disease, and the role of transplantation now requires re-evaluation.
  • Epithelioid hemangioendothelioma is also an appropriate indication for liver transplantation, even in the presence of extrahepatic metastases, unlike angiosarcoma which is associated with a very poor survival and considered as a contraindication.
  • And finally for metastatic liver disease from neuroendocrine tumours, liver transplantation can result in long-term survival and even cure in well selected patients.
  • Conversely, the value of transplantation for colorectal liver metastases (currently a contraindication) requires further evaluation by well-designed trials.
  • [MeSH-major] Liver Neoplasms / pathology. Liver Neoplasms / surgery. Liver Transplantation
  • [MeSH-minor] Bile Duct Neoplasms / surgery. Carcinoma, Hepatocellular / pathology. Carcinoma, Hepatocellular / surgery. Cholangiocarcinoma / surgery. Colorectal Neoplasms / pathology. Hemangioendothelioma / surgery. Hemangiosarcoma / surgery. Humans. Neoplasm Metastasis. Neoplasm Staging. Neuroendocrine Tumors / surgery. Survival Analysis. Survivors. Treatment Outcome

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  • (PMID = 18713148.001).
  • [ISSN] 0934-0874
  • [Journal-full-title] Transplant international : official journal of the European Society for Organ Transplantation
  • [ISO-abbreviation] Transpl. Int.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 75
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81. Nunes ML, Rault A, Teynie J, Valli N, Guyot M, Gaye D, Belleannee G, Tabarin A: 18F-FDG PET for the identification of adrenocortical carcinomas among indeterminate adrenal tumors at computed tomography scanning. World J Surg; 2010 Jul;34(7):1506-10
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  • However, only scarce data are available to evaluate its usefulness for the identification of primary adrenal carcinomas in patients with no previous history of cancer and equivocal tumors on computed tomography (CT) scan.
  • The ratio of maxSUV adrenal tumor on maxSUV liver (adrenal/liver maxSUV ratio) during 18F-FDG PET was compared to Weiss pathological criteria.
  • RESULTS: Seventeen patients had an adrenal adenoma, 2 had small size adrenal carcinomas (<5 cm), 1 had an angiosarcoma, and 3 had noncortical benign lesions.
  • An adrenal/liver maxSUV ratio above 1.6 provided 100% sensitivity, 90% specificity, and 100% negative predictive value for the diagnosis of malignant tumor.

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  • [Cites] J Clin Endocrinol Metab. 2006 Jul;91(7):2650-5 [16670169.001]
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  • (PMID = 20396886.001).
  • [ISSN] 1432-2323
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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82. Castaldo ET, Pinson CW: Liver transplantation for non-hepatocellular carcinoma malignancy. HPB (Oxford); 2007;9(2):98-103
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  • [Title] Liver transplantation for non-hepatocellular carcinoma malignancy.
  • Liver transplantation (LT) for hepatocellular carcinoma is effective for selected patients.
  • LT for other malignancies like cholangiocarcinoma (CCA), hepatoblastoma (HB), hepatic epithelioid hemangioepithelioma (HEHE), angiosarcoma (AS), and neuroendocrine tumors (NET) is being defined.
  • LT plays a role as primary surgical therapy for those individuals in whom tumors remain unresectable after chemotherapy or as rescue therapy for those who are incompletely resected, recur after resection, or develop hepatic insufficiency after chemotherapy and/or resection.
  • HEHE is a multifocal tumor that lies somewhere between benign hemangiomas and malignant AS.
  • For NET, resection of the primary tumor and all gross metastatic disease is reported to provide 5-year survival of 70-85%.

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  • (PMID = 18333123.001).
  • [ISSN] 1365-182X
  • [Journal-full-title] HPB : the official journal of the International Hepato Pancreato Biliary Association
  • [ISO-abbreviation] HPB (Oxford)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2020792
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83. Matsumoto M, Tamura M, Komiya T, Aridome G, Narita R, Hisaoka M, Ohtsuki M, Otsuji Y: Hepatic angiosarcoma: a rare liver tumor in a hemodialysis patient. Clin Nephrol; 2009 May;71(5):590-2
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  • [Title] Hepatic angiosarcoma: a rare liver tumor in a hemodialysis patient.
  • [MeSH-major] Hemangiosarcoma / diagnosis. Kidney Failure, Chronic / therapy. Liver Neoplasms / diagnosis. Renal Dialysis / methods
  • [MeSH-minor] Adult. Biopsy, Needle. Diagnosis, Differential. Fatal Outcome. Humans. Liver / pathology. Liver / radiography. Male. Tomography, X-Ray Computed

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  • (PMID = 19473625.001).
  • [ISSN] 0301-0430
  • [Journal-full-title] Clinical nephrology
  • [ISO-abbreviation] Clin. Nephrol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Germany
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84. Egea Valenzuela J, López Poveda MJ, Pérez Fuenzalida FJ, Garre Sánchez C, Martínez Barba E, Carballo Alvarez F: Hepatic angiosarcoma. Presentation of two cases. Rev Esp Enferm Dig; 2009 Jun;101(6):430-4, 434-7
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  • [Title] Hepatic angiosarcoma. Presentation of two cases.
  • Hepatic angiosarcoma is a rare primary tumor of the liver with a mesenchymal origin.
  • Diagnosis is difficult because clinical manifestations and imaging studies are inconclusive.
  • In many cases a diagnosis is obtained during necropsy, not being apparent during the course of disease.
  • When clinical manifestations begin progression is often fast, and possibilities for curative treatment are limited.We report two cases of hepatic angiosarcoma.
  • In the first one, our patient had an insidious initial course, and then suddenly presented with hepatic failure followed by acute respiratory distress.
  • A diagnosis was reached during necropsy.
  • In the second case, we initiated the study of a chronic liver disease using fine-needle aspiration biopsy, which showed findings suggestive of hepatic angiosarcoma.
  • [MeSH-major] Hemangiosarcoma. Liver Neoplasms

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  • (PMID = 19630468.001).
  • [ISSN] 1130-0108
  • [Journal-full-title] Revista española de enfermedades digestivas : organo oficial de la Sociedad Española de Patología Digestiva
  • [ISO-abbreviation] Rev Esp Enferm Dig
  • [Language] eng; spa
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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85. Sahmel J, Unice K, Scott P, Cowan D, Paustenbach D: The use of multizone models to estimate an airborne chemical contaminant generation and decay profile: occupational exposures of hairdressers to vinyl chloride in hairspray during the 1960s and 1970s. Risk Anal; 2009 Dec;29(12):1699-725
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  • The question has arisen whether occupational exposures of hairdressers to VC-containing hairsprays in hair salons were sufficient to increase the risk for developing hepatic angiosarcoma (HAS).
  • [MeSH-minor] Beauty Culture. Female. Hemangiosarcoma / epidemiology. Hemangiosarcoma / etiology. Hemangiosarcoma / history. History, 20th Century. Humans. Liver Neoplasms / epidemiology. Liver Neoplasms / etiology. Liver Neoplasms / history. Models, Theoretical. Occupational Diseases / epidemiology. Occupational Diseases / etiology. Occupational Diseases / history. Risk Assessment. United States / epidemiology. United States Occupational Safety and Health Administration

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  • Hazardous Substances Data Bank. VINYL CHLORIDE .
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  • (PMID = 19948002.001).
  • [ISSN] 1539-6924
  • [Journal-full-title] Risk analysis : an official publication of the Society for Risk Analysis
  • [ISO-abbreviation] Risk Anal.
  • [Language] eng
  • [Publication-type] Historical Article; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Air Pollutants, Occupational; 0 / Hair Preparations; WD06X94M2D / Vinyl Chloride
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86. Bismuth B, Castel H, Boleslawski E, Buob D, Lambert M, Declerck N, Canva V, Zafrani ES, Mathurin P, Pruvot FR, Dharancy S: Primary sarcoma of the liver and transplantation: a case study and literature review. Rare Tumors; 2009;1(2):e31
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  • [Title] Primary sarcoma of the liver and transplantation: a case study and literature review.
  • Primary sarcomas of the liver are rare tumors and their diagnosis is difficult to assess, particularly on percutaneous liver biopsy.
  • Epithelioid hemangioendothelioma (EHE) is an infrequent indication for liver transplantation, and angiosarcoma (AS) is a widely recognized contraindication because of its poor prognosis.
  • We report the case of a young woman who underwent liver transplantation (LT) for an infiltrative hepatic tumor with several features suggestive of EHE, although the analysis of the native liver revealed AS.

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  • (PMID = 21139910.001).
  • [ISSN] 2036-3613
  • [Journal-full-title] Rare tumors
  • [ISO-abbreviation] Rare Tumors
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2994467
  • [Keywords] NOTNLM ; angiosarcoma / epithelioid hemangioendothelioma / liver transplantation
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87. Bien E, Stachowicz-Stencel T, Balcerska A, Godzinski J, Kazanowska B, Perek-Polnik M, Madziara W, Rybczynska A, Kurylak A, Zalewska-Szewczyk B, Peregud-Pogorzelski J: Angiosarcoma in children - still uncontrollable oncological problem. The report of the Polish Paediatric Rare Tumours Study. Eur J Cancer Care (Engl); 2009 Jul;18(4):411-20
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  • [Title] Angiosarcoma in children - still uncontrollable oncological problem. The report of the Polish Paediatric Rare Tumours Study.
  • Angiosarcoma in children - still uncontrollable oncological problem.
  • The report of the Polish Paediatric Rare Tumours StudyAngiosarcoma is a rare, highly malignant vascular neoplasm with little data available on its clinical course and management in children.
  • Ten children with angiosarcoma (M/F: 6/4; aged 2, 3-16 years) registered in Polish Paediatric Rare Tumours and Soft Tissue Sarcomas Studies between 1992 and 2006.
  • Primary tumour exceeded 5 cm in seven patients and affected mainly deep tissues (heart-2, head/neck, bladder, brain, liver and upper limb - one patient each).
  • Complete primary excision was unfeasible even in local stages.
  • Angiosarcoma in children is highly aggressive with an extremely poor prognosis.
  • Complete primary excision is unfeasible, even in seemingly local stages.
  • [MeSH-major] Hemangiosarcoma / pathology. Hemangiosarcoma / therapy. Sarcoma / pathology. Sarcoma / therapy

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  • (PMID = 19490008.001).
  • [ISSN] 1365-2354
  • [Journal-full-title] European journal of cancer care
  • [ISO-abbreviation] Eur J Cancer Care (Engl)
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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88. Srivastava A, Nielsen PG, Dal Cin P, Rosenberg AE: Monophasic synovial sarcoma of the liver. Arch Pathol Lab Med; 2005 Aug;129(8):1047-9
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  • [Title] Monophasic synovial sarcoma of the liver.
  • We report a hepatic monophasic synovial sarcoma in a 60-year-old woman who presented with right upper quadrant pain subsequent to an intrahepatic bleed from a highly vascular tumor mass.
  • Imaging studies showed a dominant tumor mass in the right hepatic lobe with multiple satellite nodules.
  • A detailed physical examination and radiologic workup failed to reveal a primary tumor elsewhere.
  • A right partial hepatectomy was performed with a preoperative differential diagnosis of angiosarcoma versus hepatocellular carcinoma.
  • The presence of multiple lesions in the liver certainly suggests the possibility of metastatic disease.
  • It would, however, be very unusual for a synovial sarcoma to present as an occult primary, and the negative radiologic workup 1 month after the partial hepatectomy also argues against this possibility.
  • The clinical presentation, radiographic findings, and subsequent course in this patient was therefore most consistent with a primary monophasic synovial sarcoma of the liver.
  • [MeSH-major] Liver Neoplasms / diagnosis. Sarcoma, Synovial / diagnosis
  • [MeSH-minor] Carcinoma, Hepatocellular / diagnosis. Chemotherapy, Adjuvant. Chromosomes, Human, Pair 18. Chromosomes, Human, X. Diagnosis, Differential. Fatal Outcome. Female. Genetic Markers. Hemangiosarcoma / diagnosis. Hepatectomy. Humans. Middle Aged. Translocation, Genetic

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  • (PMID = 16048399.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Genetic Markers
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89. Hadidy A, Alsharif A, Sheikh-Ali R, Abukhalaf M, Awidi A, Abukaraki A, Nimri C, Omari A: Odontogenic myxofibroma synchronous with primary angiosarcoma of the spleen. Br J Radiol; 2010 Jan;83(985):e10-3
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  • [Title] Odontogenic myxofibroma synchronous with primary angiosarcoma of the spleen.
  • Odontogenic myxofibroma of the temporomandibular joint (TMJ) is a rare tumour; moreover, primary splenic angiosarcoma (PAS) in paediatric patients is extremely rare.
  • The TMJ swelling proved to be odontogenic myxofibroma and the abdominal pain was a result of primary splenic angiosarcoma with hepatic metastasis.
  • We report for the first time the synchronous presentation of PAS and odontogenic myxofibroma in a paediatric patient, and we describe the radiological features along with the histological diagnosis and clinical outcome.
  • [MeSH-major] Fibroma / diagnosis. Hemangiosarcoma / diagnosis. Neoplasms, Multiple Primary / diagnosis. Odontogenic Tumors / diagnosis. Splenic Neoplasms / diagnosis. Temporomandibular Joint Disorders / diagnosis
  • [MeSH-minor] Adolescent. Bone Neoplasms / secondary. Diagnosis, Differential. Fatal Outcome. Humans. Liver Neoplasms / secondary. Male

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  • (PMID = 20139242.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3487256
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90. Bernardos L, García Marín A, Rey Valcárcel C, Martín Gil J, Turégano Fuentes F: [Hepatic angiosarcoma]. Rev Esp Enferm Dig; 2008 Dec;100(12):804-6
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  • [Title] [Hepatic angiosarcoma].
  • [Transliterated title] Angiosarcoma hepático.
  • [MeSH-major] Hemangiosarcoma / pathology. Liver Neoplasms / pathology

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  • (PMID = 19222346.001).
  • [ISSN] 1130-0108
  • [Journal-full-title] Revista española de enfermedades digestivas : organo oficial de la Sociedad Española de Patología Digestiva
  • [ISO-abbreviation] Rev Esp Enferm Dig
  • [Language] spa
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Spain
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91. García-Marin A, Martín-Gil J, Nofuentes-Riera C, Vaquero-Rodríguez A, Sanz-Sánchez M, Turégano-Fuentes F: [Local resection and radiofrequency hepatic epithelioid hemangioendothelioma]. Rev Gastroenterol Mex; 2010;75(3):335-8
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  • [Title] [Local resection and radiofrequency hepatic epithelioid hemangioendothelioma].
  • Epithelioid hemangioendothelioma is an uncommon tumor of vascular endothelial cell origin with a clinical course between hemangioma and angiosarcoma.
  • Clinical manifestations and radiological findings are nonspecific, and histopathologic examination is required to establish a definitive diagnosis.
  • Currently, hepatic resection or liver transplantation is the best therapeutic options.
  • [MeSH-major] Catheter Ablation / methods. Hemangioendothelioma, Epithelioid / surgery. Liver Neoplasms / surgery

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  • (PMID = 20959187.001).
  • [ISSN] 0375-0906
  • [Journal-full-title] Revista de gastroenterología de México
  • [ISO-abbreviation] Rev Gastroenterol Mex
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Mexico
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92. Di Matteo FM, De Stefano M, Vanni B, Palermo S, Biancafarina A, Giusti D, Savino G, Di Marco C, Casalvieri L, De Antoni E: [Retroperitoneal giant mixed sarcoma. Case report]. G Chir; 2008 May;29(5):238-41
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  • CT scan showed a solid abdominal expansive mass, with compression and displacement of the left lobe of the liver, spleen, stomach, pancreas, and left kidney.
  • Histology showed a mixed liposarcoma and angiosarcoma with high grade of malignancy and positivity for vimentin, factor VIII, CD34, CD31 and negativity for S-100, CD68, AMS, AML.
  • [MeSH-major] Hemangiosarcoma / surgery. Liposarcoma / surgery. Neoplasms, Multiple Primary / surgery. Retroperitoneal Neoplasms / surgery

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  • (PMID = 18507961.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
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93. Ganguly R, Mukherjee A: Infantile hemangioendothelioma: A case report and discussion. Pathol Res Pract; 2010 Jan 15;206(1):53-8
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  • Infantile hepatic hamangioendothelioma type II is similar to angiosarcoma in terms of histomorphology and behavior.
  • Various presentations of this lesion have been reported in the literature, e.g. cases with a hepatic mass, cutaneous hemangiomas, heart failure, etc.
  • We report on a patient, male/2 years, who had two jejunal masses and a hepatic mass accompanied by lower GI bleeding and intestinal obstruction.
  • The two jejunal masses and the hepatic lesion were diagnosed as angiosarcoma histomorphologically (IHHE type II), and were positive for vascular markers (CD31 and CD34) on immunohistochemistry.
  • [MeSH-major] Hemangioendothelioma / secondary. Jejunal Neoplasms / secondary. Liver Neoplasms / pathology

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  • [Copyright] Copyright 2009 Elsevier GmbH. All rights reserved.
  • (PMID = 19321270.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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94. Cioffi-Pretti JL, Kalof AN, Ebert G, McCahill LE: Hepatic angiosarcoma five years following spontaneous intraperitoneal bleed of a hepatic mass. Rare Tumors; 2009;1(2):e33
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  • [Title] Hepatic angiosarcoma five years following spontaneous intraperitoneal bleed of a hepatic mass.
  • Primary hepatic angiosarcoma is a rare and rapidly fatal disease.
  • A CT scan showed a hepatic mass with intralesional hemorrhage, intraperitoneal blood, and splenomegaly.
  • Contralateral lobe biopsies revealed normal liver tissue.
  • A repeat biopsy demonstrated a neoplasm of vascular etiology and uncertain malignant potential.
  • By early 2008 the lesion had increased to 4.8 cm and was resected via a left hepatic lobectomy.
  • An extremely vascular lesion with surrounding dense fibrosis was identified and pathologic examination demonstrated a high-grade angiosarcoma.We are unaware of any previous reports suggesting such a prolonged natural history of hepatic angiosarcoma.
  • This case may represent the possibility of malignant transformation of a lower grade vascular neoplasm such as hepatic epithelioid hemangioendothelioma to an angiosarcoma.

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  • (PMID = 21139912.001).
  • [ISSN] 2036-3613
  • [Journal-full-title] Rare tumors
  • [ISO-abbreviation] Rare Tumors
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2994458
  • [Keywords] NOTNLM ; hepatic angiosarcoma / hepatic mass / spontaneous intraperitoneal bleed.
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95. Glickstein J, Sebelik ME, Lu Q: Cutaneous angiosarcoma of the head and neck: a case presentation and review of the literature. Ear Nose Throat J; 2006 Oct;85(10):672-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cutaneous angiosarcoma of the head and neck: a case presentation and review of the literature.
  • Cutaneous angiosarcoma of the head and neck is a rare vascular neoplasm.
  • Early diagnosis and treatment are essential for local control of this aggressive tumor but recognition can be delayed because of its rarity or because of difficulty in making a pathologic diagnosis.
  • After a diagnosis of low-grade angiosarcoma was definitively established, the lesions were locally excised with good cosmetic and functional results.
  • We review the literature on cutaneous angiosarcoma, and we discuss its epidemiology, presentation, tissue diagnosis, treatment, and prognosis in an effort to increase awareness of this rare malignancy.
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Hemangiosarcoma / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged. Humans. Liver Neoplasms / secondary. Male. Prognosis. Retroperitoneal Neoplasms / secondary. Treatment Outcome

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  • (PMID = 17124942.001).
  • [ISSN] 0145-5613
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 13
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96. Oe A, Habu D, Kawabe J, Torii K, Kawamura E, Kotani J, Hayashi T, Sakaguchi H, Shiomi S: A case of diffuse hepatic angiosarcoma diagnosed by FDG-PET. Ann Nucl Med; 2005 Sep;19(6):519-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of diffuse hepatic angiosarcoma diagnosed by FDG-PET.
  • Fluorine-18 2-deoxy-2-fluoro-D-glucose (FDG)-positron emission tomography (PET) showed diffuse abnormal accumulation throughout the entire liver.
  • She was diagnosed by histopathological examination as having hepatic angiosarcoma causing veno-occlusive disease (VOD).
  • This is the first report of hepatic angiosarcoma with FDG-PET.
  • [MeSH-major] Fluorodeoxyglucose F18. Hemangiosarcoma / complications. Hemangiosarcoma / radionuclide imaging. Hepatic Veno-Occlusive Disease / etiology. Hepatic Veno-Occlusive Disease / radionuclide imaging. Liver Neoplasms / complications. Liver Neoplasms / radionuclide imaging

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  • (PMID = 16248391.001).
  • [ISSN] 0914-7187
  • [Journal-full-title] Annals of nuclear medicine
  • [ISO-abbreviation] Ann Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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97. Hertl M, Cosimi AB: Liver transplantation for malignancy. Oncologist; 2005 Apr;10(4):269-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Liver transplantation for malignancy.
  • Liver transplantation for hepatic malignancies has emerged from an exotic and desperate approach to a well-documented and proven treatment modality for these unfortunate patients.
  • Currently, <10% of all liver transplants performed are for hepatocellular cancer (HCC).
  • Similarly, liver transplantation for HCC in the adult population yields good results for patients whose tumor masses do not exceed the Milan criteria.
  • Epitheloid hemangioendothelioma is also an appropriate indication for liver transplantation, unlike angiosarcoma.
  • Metastatic liver disease is not an indication for liver transplantation, with the exception of cases in which the primary is a neuroendocrine tumor, for which liver transplantation can result in long-term survival and even cure in a number of patients.
  • And finally, while gallbladder cancers are never an indication for liver transplantation, rare cases of cholangiocellular cancer might qualify if aggressive combination therapies, including chemotherapy and radiotherapy followed by OLT, are carried through.
  • Survival in these selected patients can approach that for patients with cholestatic liver disease.
  • [MeSH-major] Bile Duct Neoplasms / surgery. Carcinoma, Hepatocellular / surgery. Liver Neoplasms / surgery. Liver Transplantation
  • [MeSH-minor] Cholangiocarcinoma / mortality. Cholangiocarcinoma / pathology. Cholangiocarcinoma / surgery. Hemangioendothelioma, Epithelioid / mortality. Hemangioendothelioma, Epithelioid / pathology. Hemangioendothelioma, Epithelioid / surgery. Hepatoblastoma / mortality. Hepatoblastoma / pathology. Hepatoblastoma / surgery. Humans. Medical Oncology / trends. Neoplasm Metastasis. Patient Selection. Survival Rate. Treatment Outcome. Waiting Lists


98. Burns C, Harrison K, Jammer B, Zuccarini D, Lafrance B: A cancer incidence and mortality study of Dow Chemical Canada Inc. manufacturing sites. Occup Med (Lond); 2005 Dec;55(8):618-24
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  • There were no cases of angiosarcoma of the liver.
  • These cancers were included in the 12 deaths with malignant mesothelioma at Sarnia.
  • CONCLUSION: Consistent with the earlier report, lower mortality rates were observed for the major classifications of disease and malignant neoplasms.
  • Past asbestos exposure prior to 1980 is probably a contributor to the deaths due to malignant mesothelioma but is not reflected in lung cancer mortality.

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  • (PMID = 16174663.001).
  • [ISSN] 0962-7480
  • [Journal-full-title] Occupational medicine (Oxford, England)
  • [ISO-abbreviation] Occup Med (Lond)
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] England
  • [Chemical-registry-number] 1332-21-4 / Asbestos
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99. Schima W, Kölblinger C, Eisenhuber-Stadler E, Kulinna-Cosentini C, Ba-Ssalamah A: [Diseases of the hepatobiliary system as a cause of acute abdomen]. Radiologe; 2010 Mar;50(3):252, 254-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Diseases of the liver and biliary system are common causes of acute abdominal pain and gallstone disease predisposes to cholecystitis and cholangiolithiasis.
  • Pyogenic, amebic and fungal liver abscesses are reliably diagnosed with MDCT which can also be used for interventional radiologic therapy of liver abscesses by percutaneous aspiration or drainage procedures.
  • The second most common cause of liver rupture after blunt trauma is spontaneous rupture of hypervascular liver tumors (i.e., HCC, adenoma, angiosarcoma) and due to medical procedures.
  • [MeSH-major] Abdomen, Acute / diagnosis. Abdomen, Acute / etiology. Biliary Tract Diseases / complications. Biliary Tract Diseases / diagnosis. Diagnostic Imaging / methods. Liver Diseases / complications. Liver Diseases / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Humans

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  • (PMID = 20157692.001).
  • [ISSN] 1432-2102
  • [Journal-full-title] Der Radiologe
  • [ISO-abbreviation] Radiologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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100. Di Bisceglie AM, Osmack P, Brunt EM: Chemoprevention of hepatocellular carcinoma: use of tamoxifen in an animal model of hepatocarcinogenesis. J Lab Clin Med; 2005 Mar;145(3):134-8
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  • HCC often occurs against a background of liver disease, tends to present at an advanced stage, and has a poor prognosis, suggesting that it is an ideal target for chemoprevention.
  • To this end, we induced liver tumors by injecting ethyl-nitrosourea in 6-week-old male B6C3F1 mice.
  • All liver lesions (altered foci, adenomata, HCC) occurred significantly less frequently in the tamoxifen-treated group than the group given only ethylnitrosourea (HCC developed in 2 of 47 (4%) vs 11 of 44 (25%); P < .001).
  • On the other hand, retinoic acid appeared to increase the number of liver tumors, and in 2 animals angiosarcoma developed.
  • [MeSH-major] Anticarcinogenic Agents / therapeutic use. Carcinoma, Hepatocellular / prevention & control. Liver Neoplasms, Experimental / prevention & control. Tamoxifen / therapeutic use
  • [MeSH-minor] Adenoma, Liver Cell / pathology. Adenoma, Liver Cell / prevention & control. Animals. Chemoprevention. Disease Models, Animal. Ethylnitrosourea. Male. Mice. Mice, Inbred Strains. Precancerous Conditions / pathology. Precancerous Conditions / prevention & control. Tretinoin / therapeutic use

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  • (PMID = 15871304.001).
  • [ISSN] 0022-2143
  • [Journal-full-title] The Journal of laboratory and clinical medicine
  • [ISO-abbreviation] J. Lab. Clin. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anticarcinogenic Agents; 094ZI81Y45 / Tamoxifen; 5688UTC01R / Tretinoin; P8M1T4190R / Ethylnitrosourea
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