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1. Souza FF, Katkar A, den Abbeele AD, Dipiro PJ: Breast angiosarcoma metastatic to the ovary. Case Rep Med; 2009;2009:381015
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  • [Title] Breast angiosarcoma metastatic to the ovary.
  • Primary angiosarcoma can arise anywhere in the body and when it arises in the breast, it usually affects women in their 3rd and 4th decades and accounts for one in 1700-2300 cases of primary breast cancer.
  • Although unusual, breast angiosarcomas tend to metastasize hematogenously rather than lymphogenously, have high rates of local recurrence, that often develop metastases soon after treatment, and have a dismal prognosis.
  • We present a case of a solitary ovarian metastasis from angiosarcoma of the breast.

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  • (PMID = 19718246.001).
  • [ISSN] 1687-9627
  • [Journal-full-title] Case reports in medicine
  • [ISO-abbreviation] Case Rep Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2729273
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2. Mattoch IW, Robbins JB, Kempson RL, Kohler S: Post-radiotherapy vascular proliferations in mammary skin: a clinicopathologic study of 11 cases. J Am Acad Dermatol; 2007 Jul;57(1):126-33
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  • BACKGROUND: Post-radiotherapy atypical vascular lesions (AVL) in mammary skin show significant clinical and histopathologic overlap with well-differentiated angiosarcoma (AS) and pose a considerable diagnostic and managerial challenge when encountered.
  • RESULTS: Clinically, all patients were women with a mean age of 68.1 years, had a history of infiltrating breast carcinoma, and were treated by excision with postoperative radiation therapy.
  • The remaining cases met most but not all diagnostic criteria for AVL and showed some features of AS, but fell short of a definitive diagnosis of AS, including the 5 cases that were subsequently diagnosed as angiosarcoma.
  • Dermatologists and pathologists need to be aware of the overlap between AVL and well-differentiated AS and all patients who receive a diagnosis of AVL should undergo complete excision with close clinical follow-up and biopsy of any new lesions.
  • [MeSH-major] Breast Neoplasms / radiotherapy. Hemangiosarcoma / diagnosis. Neoplasms, Radiation-Induced / etiology. Neoplasms, Radiation-Induced / pathology. Skin Neoplasms / etiology. Skin Neoplasms / pathology. Vascular Diseases / etiology. Vascular Diseases / pathology


3. Courtwright A, Siamakpour-Reihani S, Arbiser JL, Banet N, Hilliard E, Fried L, Livasy C, Ketelsen D, Nepal DB, Perou CM, Patterson C, Klauber-Demore N: Secreted frizzle-related protein 2 stimulates angiogenesis via a calcineurin/NFAT signaling pathway. Cancer Res; 2009 Jun 1;69(11):4621-8
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  • Secreted frizzle-related protein 2 (SFRP2), a modulator of Wnt signaling, has recently been found to be overexpressed in the vasculature of 85% of human breast tumors; however, its role in angiogenesis is unknown.
  • Tacrolimus 3 mg/kg/d inhibited the growth of SVR angiosarcoma xenografts in mice by 46% (P = 0.04).

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  • (PMID = 19458075.001).
  • [ISSN] 1538-7445
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA142657; United States / NCI NIH HHS / CA / CA098034-05; United States / NCI NIH HHS / CA / P50 CA058223-160023; None / None / / R01 AR047901-06A2; United States / NCI NIH HHS / CA / K08 CA098034-05; United States / NCI NIH HHS / CA / P50 CA058223-160024; United States / NIAMS NIH HHS / AR / R01 AR02030; United States / NCI NIH HHS / CA / P50 CA058223; United States / NCI NIH HHS / CA / P50-CA58223; United States / NIAMS NIH HHS / AR / R01 AR047901-06A2; United States / NCI NIH HHS / CA / CA058223-160024; United States / NCI NIH HHS / CA / 1 K08CA098034-01A2; United States / NIAMS NIH HHS / AR / R01 AR047901; United States / NCI NIH HHS / CA / K08 CA098034; United States / NCI NIH HHS / CA / CA058223-160023
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Membrane Proteins; 0 / NFATC Transcription Factors; 0 / RNA, Small Interfering; 0 / SFRP2 protein, human; EC 3.1.3.16 / Calcineurin
  • [Other-IDs] NLM/ NIHMS108837; NLM/ PMC2699405
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4. Saunders ND, Marshall JS, Anderson RC: A case of chest wall angiosarcoma associated with breast implants. J Thorac Cardiovasc Surg; 2007 Oct;134(4):1076-7
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  • [Title] A case of chest wall angiosarcoma associated with breast implants.
  • [MeSH-major] Breast Implants / adverse effects. Breast Neoplasms / etiology. Breast Neoplasms / surgery. Hemangiosarcoma / etiology. Hemangiosarcoma / surgery. Thoracic Wall / pathology. Thoracic Wall / surgery
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Lymphatic Metastasis. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 17903547.001).
  • [ISSN] 1097-685X
  • [Journal-full-title] The Journal of thoracic and cardiovascular surgery
  • [ISO-abbreviation] J. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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5. Kar A, Mukhopadhyay D, Das SS, Swain NN, Das BM, Nayak M, Rath J, Satpathy S: Cytodiagnosis of angiosarcoma of breast. Indian J Pathol Microbiol; 2008 Jul-Sep;51(3):427-9
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  • [Title] Cytodiagnosis of angiosarcoma of breast.
  • A 24-year-old female presented with swelling in the left breast for one-and-a-half years associated with pain for last 4 months.
  • The case was diagnosed by preoperative cytology as angiosarcoma of breast, after which, she underwent modified radical mastectomy.
  • Angiosarcoma of breast is uncommon with extremely bad prognosis.
  • [MeSH-major] Breast Neoplasms / diagnosis. Hemangiosarcoma / diagnosis

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  • (PMID = 18723981.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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6. Biswas T, Tang P, Muhs A, Ling M: Angiosarcoma of the breast: a rare clinicopathological entity. Am J Clin Oncol; 2009 Dec;32(6):582-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma of the breast: a rare clinicopathological entity.
  • OBJECTIVES: Angiosarcoma is a rare subtype of sarcoma that usually arises after radiation therapy for primary breast cancer.
  • Primary sarcomas of the breast are rare entities and account for less than 1% of all malignant breast neoplasms.
  • We examine our institutional experience with angiosarcomas of the breast that were diagnosed and treated between 1996 and 2007.
  • METHODS: To conduct a retrospective review, all female patients with a diagnosis of angiosarcoma of the breast were identified from our pathology database.
  • RESULTS: A total of 8 patients were identified who had a histologically confirmed diagnosis of angiosarcoma of the breast.
  • Median age was 70.3 years at diagnosis (range, 35.6-85.7 years).
  • Seven (87%) patients had a history of prior radiation to the breast, whereas 1 (13%) had primary angiosarcoma.
  • CONCLUSIONS: Even though angiosarcomas are rare neoplasms, they are increasingly recognized as the result of more breast-conserving therapy.
  • High clinical suspicion and MRI may contribute to early diagnosis but a biopsy is always necessary to confirm it.
  • [MeSH-major] Breast Neoplasms / pathology. Hemangiosarcoma / pathology. Neoplasms, Radiation-Induced / pathology. Neoplasms, Second Primary / pathology

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  • (PMID = 19581792.001).
  • [ISSN] 1537-453X
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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7. Lincoln DT, Singal PK, Al-Banaw A: Growth hormone in vascular pathology: neovascularization and expression of receptors is associated with cellular proliferation. Anticancer Res; 2007 Nov-Dec;27(6B):4201-18
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  • A total of 64 benign and malignant vascular tumours were obtained from different human organ sites, including the chest wall, skin, axillary contents, duodenum, female breast, abdomen, stomach, colon, lymph node, bladder, body flank and neck regions.
  • The tumours were of the following pathological entities: Haemangioma (n = 12); haemangioendothelioma (n = 10); Castleman's disease (n = 3), haemangiopericytoma (n = 4); angiosarcoma, (n = 11), Kaposi's sarcoma with focal infiltration by lymphoma, HIV +ve (n = 7), Kaposi's sarcoma (n = 17).

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  • [ErratumIn] Anticancer Res. 2008 Mar-Apr;28(2b):1439
  • (PMID = 18225592.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Receptors, Somatotropin; 9002-72-6 / Growth Hormone
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8. Mignogna C, Simonetti S, Galloro G, Magno L, De Cecio R, Insabato L: Duodenal epithelioid angiosarcoma: immunohistochemical and clinical findings. A case report. Tumori; 2007 Nov-Dec;93(6):619-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Duodenal epithelioid angiosarcoma: immunohistochemical and clinical findings. A case report.
  • Angiosarcomas mainly involve skin and soft tissue and rarely occur in breast, liver, bone, and spleen.
  • A duodenal reddish polypoid lesion was found, which on microscopic examination turned out to be an epithelioid angiosarcoma.
  • The immunohistochemical features of the lesion supported this diagnosis.
  • The patient died eight months after the diagnosis.
  • Epithelioid angiosarcoma is an aggressive variant of angiosarcoma and must be considered in the differential diagnosis of gastrointestinal tumors.
  • [MeSH-major] Duodenal Neoplasms / pathology. Hemangioendothelioma, Epithelioid / pathology. Hemangiosarcoma / pathology

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  • (PMID = 18338501.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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9. Shet T, Malaviya A, Nadkarni M, Kakade A, Parmar V, Badwe R, Chinoy R: Primary angiosarcoma of the breast: observations in Asian Indian women. J Surg Oncol; 2006 Oct 1;94(5):368-74
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary angiosarcoma of the breast: observations in Asian Indian women.
  • BACKGROUND: Primary angiosarcomas of breast are rare tumors, with a fatal outcome.
  • RESULTS: All patients had primary angiosarcoma; no case of secondary angiosarcoma was accessioned during the study period.
  • Interesting cases encountered included an epithelioid angiosarcoma and an angiosarcoma arising on the background of a biphasic tumor.
  • The patient with well-differentiated angiosarcoma also died of metastasis albeit after a longer time.
  • CONCLUSION: Primary angiosarcoma was fatal in young Indian women even in lower grade tumors.
  • [MeSH-major] Breast Neoplasms / pathology. Hemangiosarcoma / pathology. Proto-Oncogene Proteins c-kit / biosynthesis

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  • [Copyright] Copyright (c) 2006 Wiley-Liss, Inc.
  • (PMID = 16967461.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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10. Arbiser JL, Bonner MY, Berrios RL: Hemangiomas, angiosarcomas, and vascular malformations represent the signaling abnormalities of pathogenic angiogenesis. Curr Mol Med; 2009 Nov;9(8):929-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Furthermore, we have studied malignant vascular tumors, including hemangioendothelioma and angiosarcoma and have shown distinct signaling abnormalities in these tumors.
  • The incidence of these tumors is expected to rise due to environmental insults, such as radiation and lumpectomy for breast cancer, dietary and industrial carcinogens (hepatic angiosarcoma), and chronic ultraviolet exposure and potential Agent Orange exposure.
  • [MeSH-major] Hemangioma / blood supply. Hemangiosarcoma / blood supply. Neovascularization, Pathologic / pathology. Signal Transduction. Vascular Malformations / physiopathology


11. Shrestha DB, Ravichandran D, Pittam M: Discolouration of breast skin following breast conservation therapy for breast cancer: a cautionary tale of two patients. Int J Clin Pract; 2010 Jan;64(1):112-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Discolouration of breast skin following breast conservation therapy for breast cancer: a cautionary tale of two patients.
  • [MeSH-major] Breast Neoplasms / surgery. Carcinoma, Ductal, Breast / surgery. Mastectomy, Segmental / adverse effects. Pigmentation Disorders / etiology
  • [MeSH-minor] Aged. Fatal Outcome. Female. Hemangiosarcoma / etiology. Hemangiosarcoma / surgery. Humans. Lymphatic Metastasis. Middle Aged. Neoplasm Recurrence, Local / surgery. Radiotherapy / adverse effects

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  • (PMID = 20089025.001).
  • [ISSN] 1742-1241
  • [Journal-full-title] International journal of clinical practice
  • [ISO-abbreviation] Int. J. Clin. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] Angiosarcoma of the breast
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12. Soldić Z, Salopek D, Jazvić M, Radić J, Marić-Brozić J, Tomas D, Kirac P, Bolanca A, Kusić Z: Parenchymal post-irradiation angiosarcoma: a case report. Acta Clin Croat; 2009 Sep;48(4):433-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Parenchymal post-irradiation angiosarcoma: a case report.
  • Secondary angiosarcoma is an aggressive tumor that can develop in breast cancer patients treated with conserving therapy and radiotherapy.
  • A high grade of clinical suspicion is very important for early diagnosis.
  • A case of angiosarcoma involving breast parenchyma in a patient treated with quadrantectomy and radiotherapy for T1cN1Mx breast carcinoma is presented.
  • [MeSH-major] Breast Neoplasms / pathology. Hemangiosarcoma / pathology. Neoplasms, Radiation-Induced / pathology

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  • (PMID = 20405640.001).
  • [ISSN] 0353-9466
  • [Journal-full-title] Acta clinica Croatica
  • [ISO-abbreviation] Acta Clin Croat
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
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13. West J, Liao SY, Cho D: Angiosarcoma after breast conservation: diagnostic pitfalls. Clin Breast Cancer; 2008 Feb;8(1):94-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma after breast conservation: diagnostic pitfalls.
  • Although angiosarcomas are relatively rare, they are being reported with increasing frequency in patients who have previously undergone breast conserving therapy.
  • The initial clinical presentation of angiosarcomas after breast irradiation is often similar to the presentation of recurrent breast carcinomas.
  • In addition, the histologic and cytologic appearance of posttreatment angiosarcomas can be highly suggestive of recurrent breast carcinoma.
  • An accurate diagnosis is essential, because prognosis and treatment are different for each condition.
  • An early and accurate diagnosis is aided by a high index of suspicion by clinician and pathologist.
  • Herein, a case history is presented that underscores the pitfalls in attempting to achieve an accurate diagnosis.
  • [MeSH-major] Breast Neoplasms / surgery. Hemangiosarcoma / pathology. Neoplasms, Second Primary / pathology
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Mastectomy, Segmental. Middle Aged

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  • (PMID = 18501065.001).
  • [ISSN] 1526-8209
  • [Journal-full-title] Clinical breast cancer
  • [ISO-abbreviation] Clin. Breast Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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14. Vertse G, Svastics E, Iványi A: [Postirradiation angiosarcoma of the breast]. Magy Seb; 2010 Aug;63(4):164-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Postirradiation angiosarcoma of the breast].
  • [Transliterated title] Besugárzás utáni angiosarcoma emloben.
  • Although secondary angiosarcomas (AS) are relatively rare neoplasms, they are increasingly recognized as the result of more breast conserving therapy (BCT) followed by radiotherapy.
  • The diagnosis of this very aggressive and rapidly spreading tumour is based on the immunohystochemical characteristics of the biopsy specimen.
  • 10 years later secondary AS occurred in the remaining breast.
  • [MeSH-major] Breast Neoplasms / radiotherapy. Hemangiosarcoma / diagnosis. Hemangiosarcoma / etiology. Mastectomy, Segmental. Neoplasms, Second Primary / diagnosis. Neoplasms, Second Primary / etiology

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  • (PMID = 20724241.001).
  • [ISSN] 0025-0295
  • [Journal-full-title] Magyar sebészet
  • [ISO-abbreviation] Magy Seb
  • [Language] hun
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Hungary
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers, Tumor
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16. Mobini N: Cutaneous epithelioid angiosarcoma: a neoplasm with potential pitfalls in diagnosis. J Cutan Pathol; 2009 Mar;36(3):362-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cutaneous epithelioid angiosarcoma: a neoplasm with potential pitfalls in diagnosis.
  • Angiosarcoma (AS) is a rare neoplasm.
  • This subset can histologically mimic non-vascular neoplasms and impose serious challenges in reaching the correct diagnosis.
  • We present five patients with cutaneous epithelioid angiosarcoma (EAS); in none, the clinical diagnosis included a vascular lesion.
  • Three patients had history of breast conservation surgery with/without radiation therapy.
  • Only after performing immunohistochemical studies that included vascular markers, a definitive diagnosis was possible.
  • Cutaneous EAS is a rare variant of cutaneous AS that can mimic a variety of more common, non-vascular neoplasms, creating a major pitfall in the diagnosis.
  • A careful and thorough histopathological examination and a high index of suspicion, along with appropriate immunohistochemical evaluation, can help reach a correct diagnosis and provide optimal patient care.
  • [MeSH-major] Hemangiosarcoma / pathology. Melanoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. Female. Humans. Male. Middle Aged

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  • (PMID = 19220634.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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17. Johnson KD, Glinskii OV, Mossine VV, Turk JR, Mawhinney TP, Anthony DC, Henry CJ, Huxley VH, Glinsky GV, Pienta KJ, Raz A, Glinsky VV: Galectin-3 as a potential therapeutic target in tumors arising from malignant endothelia. Neoplasia; 2007 Aug;9(8):662-70
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  • Angiosarcoma (ASA) in humans and hemangiosarcoma (HSA) in dogs are deadly neoplastic diseases characterized by an aggressive growth of malignant cells with endothelial phenotype, widespread metastasis, and poor response to chemotherapy.

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  • (PMID = 17786185.001).
  • [ISSN] 1476-5586
  • [Journal-full-title] Neoplasia (New York, N.Y.)
  • [ISO-abbreviation] Neoplasia
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R37 CA046120-19; United States / NCI NIH HHS / CA / 5R01 CA89827; United States / NCI NIH HHS / CA / R37 CA046120; United States / NHLBI NIH HHS / HL / R01 HL078816; United States / NCI NIH HHS / CA / R01 CA089827; United States / NCI NIH HHS / CA / P50 CA69568; United States / NCI NIH HHS / CA / P01 CA093900-01A2; United States / NCI NIH HHS / CA / P50 CA069568; United States / NCI NIH HHS / CA / P01 CA093900
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Galectin 3
  • [Other-IDs] NLM/ PMC1950436
  • [Keywords] NOTNLM ; Angiosarcoma / apoptosis / chemotherapy / doxorubicin / galectin-3
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18. Aguiar Bujanda D, Camacho Galán R, Bastida Iñarrea J, Aguiar Morales J, Conde Martel A, Rivero Suárez P, de Armas Diaz F, Bohn Sarmiento U, Cabrera Suárez MA: Angiosarcoma of the abdominal wall after dermolipectomy in a morbidly obese man. A rare form of presentation of Stewart-Treves syndrome. Eur J Dermatol; 2006 May-Jun;16(3):290-2
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  • [Title] Angiosarcoma of the abdominal wall after dermolipectomy in a morbidly obese man. A rare form of presentation of Stewart-Treves syndrome.
  • Angiosarcoma is a rare malignant tumor, with a predilection for skin in the head and neck region, although it has been described in many other locations.
  • Its association with chronic lymphedema is well known, mainly in the setting of postmastectomy lymphedema of the arm in breast cancer patients (termed Stewart-Treves syndrome).
  • However, angiosarcoma can appear in lower limbs with chronic lymphedema and rarely in other locations such as the abdominal wall.
  • Herein, we present a unique case of angiosarcoma developing in the abdominal wall of a morbidly obese patient after extensive dermolipectomy.
  • [MeSH-major] Abdominal Wall / pathology. Dermatologic Surgical Procedures. Hemangiosarcoma / diagnosis. Lipectomy / methods. Obesity, Morbid / complications

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  • (PMID = 16709497.001).
  • [ISSN] 1167-1122
  • [Journal-full-title] European journal of dermatology : EJD
  • [ISO-abbreviation] Eur J Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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19. Abedalthagafi M, Rushing EJ, Auerbach A, Desouki MM, Marwaha J, Wang Z, Fanburg-Smith JC: Sporadic cutaneous angiosarcomas generally lack hypoxia-inducible factor 1alpha: a histologic and immunohistochemical study of 45 cases. Ann Diagn Pathol; 2010 Feb;14(1):15-22
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  • Cutaneous angiosarcoma (AS) is a rare malignant neoplasm of dermis composed of infiltrating cells of endothelial phenotype with overall poor prognosis.
  • Although autocrine stimulation by vascular endothelial growth factor secretion may play a role in the pathogenesis of angiosarcoma, its mechanism has not been fully established.
  • The stability of HIF can regulate key proteins in angiogenesis and the alpha-subunit has been found in epithelial tumors, only 1 case of human retroperitoneal angiosarcoma, and rare vascular proliferations and tumors in knockout mice.
  • Cases coded as "angiosarcoma" of dermis were culled and re-reviewed for inclusion as AS, based on patient folder, slides, and obtained immunohistochemistry including CD31 and smooth muscle actin (SMA).
  • There was no history of other primary, lymphedema, radiation, breast-associated, or thorotrast-induced angiosarcoma.
  • Cutaneous angiosarcoma is largely found on the scalp of older individuals.
  • Requirement for diagnosis includes extravascular proliferation of atypical endothelial cells with mitotic activity in vasoformative, solid, and papillary patterns.
  • Cutaneous angiosarcoma generally lacks HIF-1alpha expression.
  • [MeSH-major] Dermis / metabolism. Hemangiosarcoma / metabolism. Hypoxia-Inducible Factor 1, alpha Subunit / metabolism. Neovascularization, Pathologic / metabolism. Skin Neoplasms / metabolism

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  • [Copyright] Published by Elsevier Inc.
  • (PMID = 20123452.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / HIF1A protein, human; 0 / Hypoxia-Inducible Factor 1, alpha Subunit
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20. Champeaux-Orange E, Bonneau C, Raharimanana B, Favre A, Ibrahim M, Breteau N: [Primary breast angiosarcoma: two case reports]. Cancer Radiother; 2009 Jun;13(3):209-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Primary breast angiosarcoma: two case reports].
  • [Transliterated title] Angiosarcome mammaire primitif: à propos de deux cas.
  • Primary angiosarcoma is a rare type of breast cancer, the diagnosis is difficult to establish and it has the worst prognostic of all breast malignancies.
  • Two cases of primary breast angiosarcoma have been observed at the centre Henry Kaplan of Tours and at the hospital La Source of Orleans since 2001.
  • [MeSH-major] Breast Neoplasms / pathology. Hemangiosarcoma / pathology

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  • (PMID = 19410492.001).
  • [ISSN] 1278-3218
  • [Journal-full-title] Cancer radiothérapie : journal de la Société française de radiothérapie oncologique
  • [ISO-abbreviation] Cancer Radiother
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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21. Kunkel T, Mylonas I, Mayr D, Friese K, Sommer HL: Recurrence of secondary angiosarcoma in a patient with post-radiated breast for breast cancer. Arch Gynecol Obstet; 2008 Nov;278(5):497-501
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recurrence of secondary angiosarcoma in a patient with post-radiated breast for breast cancer.
  • INTRODUCTION: Angiosarcoma of the breast is a rare finding.
  • Two different subtypes of angiosarcomas have been described: (a) the Stewart-Treves syndrome and (b) the cutaneous post-radiation angiosarcoma.
  • We report a case where both types of angiosarcoma occurred.
  • CASE REPORT: At first, an angiosarcoma affecting parenchyma of the breast was observed after radiotherapy following breast conserving therapy and a history of lymphoedema of the radiated area.
  • Additionally, a subsequent local recurrence of the angiosarcoma of the skin after mastectomy and complete resection of the primary angiosarcoma was diagnosed.
  • Additionally, every oncologist should be aware of this rare complication as quick diagnosis and prompt surgical treatment is indispensable due to the aggressive entity of angiosarcoma.
  • [MeSH-major] Breast Neoplasms / therapy. Hemangiosarcoma / therapy. Neoplasm Recurrence, Local / therapy. Skin Neoplasms / therapy

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  • (PMID = 18305948.001).
  • [ISSN] 0932-0067
  • [Journal-full-title] Archives of gynecology and obstetrics
  • [ISO-abbreviation] Arch. Gynecol. Obstet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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22. Fernández Ortega A, Gil Gil JM, Urruticoetxea A, Serra Payró JM: Angiosarcoma of the breast. Two cases following breast conserving treatment for invasive carcinoma. Clin Transl Oncol; 2006 Jul;8(7):536-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma of the breast. Two cases following breast conserving treatment for invasive carcinoma.
  • Angiosarcoma of the breast is a rare malignant tumour.
  • It can be primary or secondary in women who have been treated of a ductal carcinoma of the breast.
  • [MeSH-major] Brachytherapy. Breast Neoplasms / etiology. Carcinoma, Ductal, Breast / radiotherapy. Carcinoma, Ductal, Breast / surgery. Hemangiosarcoma / etiology. Mastectomy, Segmental. Neoplasms, Second Primary / etiology

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  • (PMID = 16870544.001).
  • [ISSN] 1699-048X
  • [Journal-full-title] Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
  • [ISO-abbreviation] Clin Transl Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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23. Hanasono MM, Osborne MP, Dielubanza EJ, Peters SB, Gayle LB: Radiation-induced angiosarcoma after mastectomy and TRAM flap breast reconstruction. Ann Plast Surg; 2005 Feb;54(2):211-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Radiation-induced angiosarcoma after mastectomy and TRAM flap breast reconstruction.
  • Radiation-induced angiosarcoma of the breast is being reported with increasing frequency as a result of the increased use of radiation therapy in conjunction with breast conservation surgery.
  • The authors present a case of angiosarcoma occurring in a patient 6 years after undergoing mastectomy for invasive duct carcinoma with immediate transverse rectus abdominis musculocutaneous flap reconstruction followed by postoperative radiation therapy.
  • The diagnosis of angiosarcoma was made by skin biopsy performed by the patient's reconstructive surgeon on routine follow-up examination.
  • This is the first reported case of postradiation angiosarcoma occurring in a postmastectomy breast reconstructed with autogenous tissue and it is unusual in that the cancer invaded the musculocutaneous flap.
  • Diagnosis and management recommendations for radiation-induced angiosarcoma are discussed.
  • [MeSH-major] Breast Neoplasms / surgery. Carcinoma, Ductal, Breast / surgery. Hemangiosarcoma / etiology. Mastectomy, Modified Radical. Neoplasms, Radiation-Induced / surgery

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  • (PMID = 15655476.001).
  • [ISSN] 0148-7043
  • [Journal-full-title] Annals of plastic surgery
  • [ISO-abbreviation] Ann Plast Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ki-67 Antigen
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24. Sher T, Hennessy BT, Valero V, Broglio K, Woodward WA, Trent J, Hunt KK, Hortobagyi GN, Gonzalez-Angulo AM: Primary angiosarcomas of the breast. Cancer; 2007 Jul 1;110(1):173-8
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  • [Title] Primary angiosarcomas of the breast.
  • BACKGROUND: The purpose of the study was to describe the clinicopathologic characteristics and clinical outcomes of patients with primary breast angiosarcoma.
  • METHODS: The institutional database was searched to identify breast angiosarcoma patients seen between 1965 and 2002.
  • Median tumor size at diagnosis was 5.5 cm.
  • Thirteen (18.8%) patients received prior radiation for invasive breast carcinoma.
  • CONCLUSIONS: Breast angiosarcoma is frequently advanced at diagnosis and has a tendency for local-regional recurrence.
  • [MeSH-major] Breast Neoplasms / pathology. Hemangiosarcoma / pathology

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  • [Copyright] Copyright (c) 2007 American Cancer Society.
  • (PMID = 17541936.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / L30 CA123630; United States / NCI NIH HHS / CA / L30 CA123630-01; United States / NCI NIH HHS / CA / L30 CA123630-02
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Estrogen; 0 / Receptors, Progesterone
  • [Other-IDs] NLM/ NIHMS283619; NLM/ PMC4329779
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25. AbdullGaffar B: Pseudoangiomatous stromal hyperplasia of the breast. Arch Pathol Lab Med; 2009 Aug;133(8):1335-8
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  • [Title] Pseudoangiomatous stromal hyperplasia of the breast.
  • Pseudoangiomatous stromal hyperplasia is a relatively common lesion of the breast.
  • Histologically, it can be confused with low-grade angiosarcoma.
  • [MeSH-major] Breast Diseases / pathology
  • [MeSH-minor] Antineoplastic Agents, Hormonal / therapeutic use. Biomarkers / metabolism. Diagnosis, Differential. Female. Fibroblasts / ultrastructure. Hemangiosarcoma / diagnosis. Humans. Hyperplasia / pathology. Male. Mammography. Mastectomy. Prognosis. Stromal Cells / ultrastructure. Tamoxifen / therapeutic use

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  • (PMID = 19653734.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Hormonal; 0 / Biomarkers; 094ZI81Y45 / Tamoxifen
  • [Number-of-references] 23
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26. Taira N, Ohsumi S, Aogi K, Maeba T, Kawamura S, Nishimura R, Takashima S: Nodular pseudoangiomatous stromal hyperplasia of mammary stroma in a case showing rapid tumor growth. Breast Cancer; 2005;12(4):331-6
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  • Pseudoangiomatous stromal hyperplasia (PASH) is an uncommon benign breast disease that presents as a localized breast mass.
  • Breast tissue affected by PASH is characterized by a dense, collagenous proliferation of mammary stroma, forming interanastomosing capillary-like spaces.
  • The importance of this benign lesion lies in distinguishing it from low grade angiosarcoma.
  • We report a case of a 38-year-old woman who presented with a rapidly growing breast tumor.
  • She visited our hospital with a complaint of a painless right breast mass.
  • A fine-needle aspiration sample of the breast mass showed some clusters of epithelial cells with small papillary structures and many scattered stromal cells with naked nuclei.
  • Based on these findings, a provisional diagnosis of fibroadenoma was made and the patient was followed up.
  • Histologic examination revealed normal breast ducts and lobules, and specific proliferative epithelial changes were not seen.
  • The lobular and duct structure of the breast parenchyma were separated by an increased amount of stroma.
  • [MeSH-major] Breast / pathology. Breast Diseases / pathology. Breast Diseases / radiography. Breast Neoplasms / radiography
  • [MeSH-minor] Adult. Diagnosis, Differential. Disease Progression. Female. Humans. Hyperplasia. Stromal Cells / pathology


27. Fayette J, Martin E, Piperno-Neumann S, Le Cesne A, Robert C, Bonvalot S, Ranchère D, Pouillart P, Coindre JM, Blay JY: Angiosarcomas, a heterogeneous group of sarcomas with specific behavior depending on primary site: a retrospective study of 161 cases. Ann Oncol; 2007 Dec;18(12):2030-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PATIENTS AND METHODS: We reviewed 161 files of angiosarcoma treated in three institutions of the French Sarcoma Group from 1980 to 2004.
  • Primary sites were the breast (35%), skin (20%) and soft tissues (13%).
  • At initial diagnosis, 31 (19%) had metastases.
  • With an average time since initial diagnosis of 8.1 years, 123 (76%) patients progressed and 76 (47%) died.
  • In multivariate analysis, liver primary site [relative risk (RR) = 12.62], performance status (PS) of two or more (RR = 3.83), presence of metastases at diagnosis (RR = 2.50), soft tissue tumor (RR = 0.31) were correlated to OS.

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  • (PMID = 17974557.001).
  • [ISSN] 1569-8041
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] England
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28. Taib N, Yip Ch, Ranganathan S, Moosa F, Mun K: Haemorrhaging lesion in the breast: is there a role for embolisation? Biomed Imaging Interv J; 2006 Jul;2(3):e30
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  • [Title] Haemorrhaging lesion in the breast: is there a role for embolisation?
  • Angiosarcoma of the breast is an extremely rare condition.
  • This case illustrates the use of embolisation as a modality of treatment for primary breast angiosarcoma.

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  • (PMID = 21614243.001).
  • [ISSN] 1823-5530
  • [Journal-full-title] Biomedical imaging and intervention journal
  • [ISO-abbreviation] Biomed Imaging Interv J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Malaysia
  • [Other-IDs] NLM/ PMC3097628
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29. Chirife AM, Bello L, Celeste F, Giménez L, Gorostidy S: [Primary sarcomas of the breast]. Medicina (B Aires); 2006;66(2):135-8
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  • [Title] [Primary sarcomas of the breast].
  • [Transliterated title] Sarcomas primarios de mama.
  • Primary sarcomas of the breast are extremely rare with less than 1% of all malignant tumours of the breast reported in literature.
  • At our Institution 1315 malignant tumours of the breast were diagnosed between 1999-2004; nine of them corresponded to primary sarcomas: angiosarcoma (3), leiomyosarcoma (1), low-grade fibromyxoid sarcoma (1), dematofibrosarcoma protuberans (1), liposarcoma (1), osteosarcoma (1), malignant peripheral nerve sheath tumour (1).
  • [MeSH-major] Breast Neoplasms. Sarcoma


30. Kinderyte R, Alisauskaite L, Juodzbaliene EB, Juozaityte E: [Angiosarcoma of the breast: a case report and literature review]. Medicina (Kaunas); 2006;42(7):580-5
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  • [Title] [Angiosarcoma of the breast: a case report and literature review].
  • Sarcoma of the breast is a rare tumor (makes up 0.5 to 1% of all malignant breast tumors).
  • In literature, only isolated cases of primary angiosarcoma of the breast were described.
  • Secondary angiosarcomas are more frequently diagnosed in women and mostly in patients who underwent breast-conserving surgery and were treated by radiotherapy.
  • In this article a very rare case of angiosarcoma of the breast is presented.
  • The tumor in the breast was diagnosed after breast trauma.
  • After surgery the diagnosis of hematoma was made.
  • After review of histopathology slides the likely diagnosis of angiosarcoma of the breast was made.
  • A patient from the time of diagnosis survived for 8 months.
  • The mean survival of patients with angiosarcoma of the breast, described in literature, ranges from 13 to 22 months, and the treatment in this case most likely could not have an effect on survival of the patient.
  • [MeSH-major] Breast Neoplasms. Hemangiosarcoma
  • [MeSH-minor] Adult. Breast / pathology. Diagnosis, Differential. Female. Humans. Lung Neoplasms / radiography. Lung Neoplasms / secondary. Lymphatic Metastasis / diagnosis. Mastectomy, Simple. Prognosis. Radiography, Thoracic. Time Factors

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  • (PMID = 16861841.001).
  • [ISSN] 1648-9144
  • [Journal-full-title] Medicina (Kaunas, Lithuania)
  • [ISO-abbreviation] Medicina (Kaunas)
  • [Language] lit
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Lithuania
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31. Asmane I, Litique V, Heymann S, Marcellin L, Métivier AC, Duclos B, Bergerat JP, Kurtz JE: Adriamycin, cisplatin, ifosfamide and paclitaxel combination as front-line chemotherapy for locally advanced and metastatic angiosarcoma. Analysis of three case reports and review of the literature. Anticancer Res; 2008 Sep-Oct;28(5B):3041-5
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  • [Title] Adriamycin, cisplatin, ifosfamide and paclitaxel combination as front-line chemotherapy for locally advanced and metastatic angiosarcoma. Analysis of three case reports and review of the literature.
  • Angiosarcoma represents 1 to 2% of soft tissue tumors.
  • It originates from endothelial cells of small blood vessels and may affect a variety of organs, including the retroperitoneum, skeletal muscle, subcutis, liver, heart and breast.
  • The outcome of angiosarcoma is poor for those patients in whom aggressive surgery cannot be considered.
  • We report three cases of angiosarcoma in which first-line chemotherapy with adriamycin 40 mg/m2 day 1, ifosfamide 3 g/m2 day 1-2, cisplatin 35 mg/m2 day 1-2 and paclitaxel 175 mg/m2 day 3 led to clinically meaningful responses.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bone Neoplasms / drug therapy. Breast Neoplasms / drug therapy. Hemangiosarcoma / drug therapy. Soft Tissue Neoplasms / drug therapy

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  • (PMID = 19031953.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 80168379AG / Doxorubicin; P88XT4IS4D / Paclitaxel; Q20Q21Q62J / Cisplatin; UM20QQM95Y / Ifosfamide
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32. de Giorgi V, Santi R, Grazzini M, Papi F, Gori A, Rossari S, Massi D, Lotti T: Synchronous angiosarcoma, melanoma and morphea of the breast skin 14 years after radiotherapy for mammary carcinoma. Acta Derm Venereol; 2010 May;90(3):283-6
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  • [Title] Synchronous angiosarcoma, melanoma and morphea of the breast skin 14 years after radiotherapy for mammary carcinoma.
  • With the improvement in survival after breast cancer there has been increasing interest in the long-term effects of radiotherapy, including the development of tumours.
  • Compared with the general population, breast cancer survivors have a 10-50% higher risk of developing a second cancer.
  • We describe here the case of a 68-year-old woman who developed synchronous cutaneous angiosarcoma, melanoma and morphea of the breast skin and the local area, 14 years after radiotherapy for breast carcinoma.
  • Given the risk of post-radiation secondary primaries in breast cancer patients, long-term surveillance is necessary, with particular attention being paid to skin changes in the irradiation field.
  • [MeSH-major] Breast Neoplasms / radiotherapy. Carcinoma / radiotherapy. Hemangiosarcoma / etiology. Melanoma / etiology. Neoplasms, Radiation-Induced / etiology. Neoplasms, Second Primary / etiology. Scleroderma, Localized / etiology. Skin Neoplasms / etiology


33. Scalise A, Bertani A, Forlini W, Pierangeli M, Piedimonte A: Cutaneous angiosarcoma of the skin: three rare cases. Plast Reconstr Surg; 2006 Feb;117(2):687-8
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  • [Title] Cutaneous angiosarcoma of the skin: three rare cases.
  • [MeSH-major] Hemangiosarcoma / surgery. Skin Neoplasms / surgery. Surgical Flaps
  • [MeSH-minor] Aged. Aged, 80 and over. Breast Neoplasms / surgery. Fatal Outcome. Female. Humans. Lymphatic Metastasis. Male. Nose Neoplasms / surgery. Scalp

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  • (PMID = 16462373.001).
  • [ISSN] 1529-4242
  • [Journal-full-title] Plastic and reconstructive surgery
  • [ISO-abbreviation] Plast. Reconstr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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34. Neuhaus SJ, Pinnock N, Giblin V, Fisher C, Thway K, Thomas JM, Hayes AJ: Treatment and outcome of radiation-induced soft-tissue sarcomas at a specialist institution. Eur J Surg Oncol; 2009 Jun;35(6):654-9
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  • RESULTS: Previous breast cancer was the most common indication for radiotherapy.
  • The only relationship for histology with site was for angiosarcoma (n=9), all of which developed on the chest wall/breast after irradiation for breast cancer.

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  • (PMID = 19112005.001).
  • [ISSN] 1532-2157
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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35. Pai MR, Upadhyaya K, Naik R, Malhotra S: Bilateral angiosarcoma breast diagnosed by fine needle aspiration cytology. Indian J Pathol Microbiol; 2008 Jul-Sep;51(3):421-3
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  • [Title] Bilateral angiosarcoma breast diagnosed by fine needle aspiration cytology.
  • Concurrent or synchronous angiosarcoma (AS) of breast is a rarity.
  • Specific recognition of this neoplasm in cytological specimens is difficult and conclusive diagnosis in the absence of ancillary methods is achieved only uncommonly.
  • This case report emphasizes that when aspiration smears show vasoformative features consisting of microacini, arborizing microtissue fragments and intracytoplasmic lumen against a bloody background, diagnosis can be made conclusively by FNA with immunohistochemical confirmation.
  • [MeSH-major] Breast Neoplasms / diagnosis. Hemangiosarcoma / diagnosis

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  • (PMID = 18723979.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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36. Gonne E, Collignon J, Kurth W, Thiry A, Henry F, Jerusalem G, Gennigens C: [Angiosarcoma in chronic lymphoedema: a case of Stewart-Treves syndrome]. Rev Med Liege; 2009 Jul-Aug;64(7-8):409-13
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  • [Title] [Angiosarcoma in chronic lymphoedema: a case of Stewart-Treves syndrome].
  • [Transliterated title] Angiosarcome sur lymphoedème chronique: un cas de syndrome de Stewart-Treves.
  • The Stewart-Treves Syndrome is defined as an angiosarcoma (very aggressive malignant tumor originating from endothelial cells) appearing in a specific clinical setting.
  • This tumor develops in patients suffering from chronic lymphedema of the upper limb following mastectomy and axillary lymph node dissection for breast cancer.
  • The diagnosis relies on medical history, clinical examination and a histological assesment (biopsy or resection).
  • [MeSH-major] Arm / pathology. Lymphangiosarcoma / diagnosis. Lymphedema / complications. Neoplasms, Second Primary / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Breast Neoplasms / pathology. Breast Neoplasms / surgery. Carcinoma / pathology. Carcinoma / surgery. Female. Humans. Lymph Node Excision / adverse effects. Mastectomy / methods. Middle Aged. Prognosis. Syndrome


37. Miettinen M, Lasota J: KIT (CD117): a review on expression in normal and neoplastic tissues, and mutations and their clinicopathologic correlation. Appl Immunohistochem Mol Morphol; 2005 Sep;13(3):205-20
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  • Other KIT-positive normal cells include epithelial cells in skin adnexa, breast, and subsets of cerebellar neurons.
  • KIT positivity has been variably reported in sarcomas such as angiosarcoma, Ewing sarcoma, synovial sarcoma, leiomyosarcoma, and MFH; results of the last three are controversial.
  • Also, KIT is expressed in pulmonary and other small cell carcinomas, adenoid cystic carcinoma, renal chromophobe carcinoma, thymic, and some ovarian and few breast carcinomas.

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  • (PMID = 16082245.001).
  • [ISSN] 1541-2016
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
  • [Number-of-references] 239
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38. Granier G, Lemoine MC, Mares P, Pignodel C, Marty-Double C: [Primary angiosarcoma of the male breast]. Ann Pathol; 2005 Jun;25(3):235-9
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  • [Title] [Primary angiosarcoma of the male breast].
  • [Transliterated title] Angiosarcome primitif du sein chez l'homme.
  • We report an exceptional case of primary breast angiosarcoma in a 58-year-old man.
  • This is a very rare breast tumor (0.04% of breast tumors) which may be difficult to diagnose.
  • Diagnosis should be established as early as possible because the 10-year overall survival rate is 80% for low grade tumors and only 20% for high grade tumors.
  • [MeSH-major] Breast Neoplasms / pathology. Hemangiosarcoma / pathology

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  • (PMID = 16230950.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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39. Brush M, Zhang J, Schuetze S, Sires B: Angiosarcoma metastatic to the orbit. Ophthal Plast Reconstr Surg; 2006 Jan-Feb;22(1):62-4
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  • [Title] Angiosarcoma metastatic to the orbit.
  • A 61-year-old woman developed metastatic angiosarcoma in her left orbit.
  • Diagnosis was confirmed with an incisional orbital biopsy and special markers.
  • Angiosarcoma was confirmed with histologic analysis.
  • Chemotherapy may be a useful palliative adjunct in the control of metastatic orbital angiosarcoma.
  • [MeSH-major] Breast Neoplasms / pathology. Hemangiosarcoma / secondary. Orbital Neoplasms / secondary
  • [MeSH-minor] Biopsy. Diagnosis, Differential. Fatal Outcome. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Middle Aged

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  • (PMID = 16418673.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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40. Zúbor P, Kajo K, Dussan CA, Szunyogh N, Danko J: Rapidly growing nodular pseudoangiomatous stromal hyperplasia of the breast in an 18-year-old girl. APMIS; 2006 May;114(5):389-92
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  • [Title] Rapidly growing nodular pseudoangiomatous stromal hyperplasia of the breast in an 18-year-old girl.
  • Pseudoangiomatous stromal hyperplasia (PASH) of the breast is a rare benign proliferation of mesenchymal stromal cells with irregular slit-like formations resembling angiomatous structures.
  • In the majority of cases this lesion is a focal microscopic finding in breast biopsies performed for benign or malignant diseases.
  • A large 12 x 9 x 3.5 cm rapidly growing nodular form of PASH of the breast in an 18-year-old woman is here described with clinical and histological findings.
  • Different diagnostic lesions, such as giant fibroadenoma and low-grade angiosarcoma, are discussed.
  • To the authors' knowledge this is only the fourth case of nodular PASH of the breast reported in the English literature.
  • [MeSH-major] Breast / cytology. Breast / pathology. Breast Neoplasms / diagnosis. Neoplasms, Muscle Tissue / pathology
  • [MeSH-minor] Adolescent. Anovulation. Diagnosis, Differential. Female. Humans. Hyperplasia / diagnosis. Hyperplasia / pathology. Progesterone / blood. Stromal Cells / pathology

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  • (PMID = 16725017.001).
  • [ISSN] 0903-4641
  • [Journal-full-title] APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
  • [ISO-abbreviation] APMIS
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 4G7DS2Q64Y / Progesterone
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41. Brenn T, Fletcher CD: Radiation-associated cutaneous atypical vascular lesions and angiosarcoma: clinicopathologic analysis of 42 cases. Am J Surg Pathol; 2005 Aug;29(8):983-96
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  • [Title] Radiation-associated cutaneous atypical vascular lesions and angiosarcoma: clinicopathologic analysis of 42 cases.
  • Cutaneous angiosarcoma is a rare but well-recognized complication after radiation therapy.
  • A total of 42 cases diagnosed as either radiation-associated cutaneous vascular lesions or angiosarcoma were retrieved from departmental and consultation files from 1995 to 2003.
  • Reasons for radiation included breast carcinoma (35 cases) and a variety of other lesions (mainly malignant disease).
  • The time interval from radiation was significantly shorter for the development of AVL (median, 3.5 years) compared with cutaneous angiosarcoma (median, 6 years).
  • Histologic evaluation revealed 26 lesions meeting criteria for angiosarcoma, ranging from morphologically low-grade to high-grade; 16 cases were classified as AVLs.
  • All patients with systemic relapse had an initial diagnosis of angiosarcoma.
  • One patient with an AVL had a recurrence at the same site, 3 patients developed additional new lesions, and 1 patient developed multiple small papules on the chest wall, which progressed from an AVL to angiosarcoma.
  • [MeSH-major] Hemangiosarcoma / etiology. Hemangiosarcoma / pathology. Neoplasms, Radiation-Induced / pathology. Skin / blood supply. Skin / pathology. Skin Neoplasms / etiology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Breast Neoplasms / radiotherapy. Female. Follow-Up Studies. Humans. Middle Aged. Neoplasm Recurrence, Local. Neoplasms / radiotherapy. Time Factors

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  • (PMID = 16006792.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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42. Gherardi G, Rossi S, Perrone S, Scanni A: Angiosarcoma after breast-conserving therapy: fine-needle aspiration biopsy, immunocytochemistry, and clinicopathologic correlates. Cancer; 2005 Jun 25;105(3):145-51
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  • [Title] Angiosarcoma after breast-conserving therapy: fine-needle aspiration biopsy, immunocytochemistry, and clinicopathologic correlates.
  • BACKGROUND: Angiosarcoma that arises after breast-conserving therapy can present clinically as a cutaneous and/or subcutaneous breast lump, which is misinterpreted easily as a recurrence of carcinoma.
  • To the authors' knowledge, the role of fine-needle aspiration (FNA) cytology in the early diagnosis of this life-threatening complication of breast carcinoma therapy has not been established fully.
  • METHODS: The authors studied three new patients with this type of secondary angiosarcoma diagnosed by FNA biopsy and immunocytochemistry, reviewed the literature on the topic, and examined relevant differential diagnostic issues.
  • RESULTS: Patients presented with a discrete skin lump that had arisen several years after breast-conservative therapy for early-stage breast carcinoma near the scar from the previous surgery.
  • Immunostaining of smears, however, provided conclusive evidence of the endothelial differentiation of tumor cells, and an FNA diagnosis of angiosarcoma was rendered in all patients.
  • The histopathology of all surgically excised tumors confirmed the diagnosis of high-grade angiosarcoma.
  • CONCLUSIONS: Based on the authors' experience, the FNA cytologic appearance of angiosarcoma that presented as a breast skin nodule in a breast carcinoma survivor easily could have been misinterpreted as carcinoma.
  • A correct diagnosis of this tumor relies on the proper evaluation of clinical findings and, as also shown by a review of the literature, requires immunocytochemical evidence of endothelial differentiation.
  • [MeSH-major] Biopsy, Fine-Needle. Breast Neoplasms / pathology. Breast Neoplasms / surgery. Hemangiosarcoma / secondary. Mastectomy, Segmental / adverse effects. Skin Neoplasms / secondary
  • [MeSH-minor] Aged. Aged, 80 and over. Carcinoma in Situ / pathology. Carcinoma in Situ / surgery. Carcinoma, Ductal, Breast / secondary. Carcinoma, Ductal, Breast / surgery. Carcinoma, Lobular / secondary. Carcinoma, Lobular / surgery. Female. Humans. Immunohistochemistry. Neoplasm Staging. Prognosis. Risk Assessment. Sampling Studies. Sensitivity and Specificity. Survival Rate

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  • (PMID = 15844179.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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43. Gambini D, Visintin R, Locatelli E, Galassi B, Bareggi C, Runza L, Onida F, Tomirotti M: Paclitaxel-dependent prolonged and persistent complete remission four years from first recurrence of secondary breast angiosarcoma. Tumori; 2009 Nov-Dec;95(6):828-31
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  • [Title] Paclitaxel-dependent prolonged and persistent complete remission four years from first recurrence of secondary breast angiosarcoma.
  • Among angiosarcomas, radiation-induced breast sarcomas (RIBS) represent a well-known entity generally characterized by a poor outcome, especially in patients with advanced disease.
  • We report a case of a patient having a secondary breast angiosarcoma recurring early after surgery, who achieved complete remission following treatment with weekly paclitaxel.
  • [MeSH-major] Angiogenesis Inhibitors / therapeutic use. Antineoplastic Agents, Phytogenic / therapeutic use. Breast Neoplasms / drug therapy. Hemangiosarcoma / drug therapy. Mastectomy, Segmental. Neoplasm Recurrence, Local / drug therapy. Paclitaxel / therapeutic use

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  • (PMID = 20210253.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Antineoplastic Agents, Phytogenic; P88XT4IS4D / Paclitaxel
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44. Virtanen A, Pukkala E, Auvinen A: Angiosarcoma after radiotherapy: a cohort study of 332,163 Finnish cancer patients. Br J Cancer; 2007 Jul 2;97(1):115-7
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  • [Title] Angiosarcoma after radiotherapy: a cohort study of 332,163 Finnish cancer patients.
  • We evaluated the risk of angiosarcoma after radiotherapy among all patients with cancers of breast, cervix uteri, corpus uteri, lung, ovary, prostate, or rectum, and lymphoma diagnosed in Finland during 1953-2003, identified from the Finnish Cancer Registry.
  • In the follow-up of 1.8 million person-years at risk, 19 angiosarcomas developed, all after breast and gynaecological cancer.
  • Although an increased risk of angiosarcoma among cancer patients is evident, especially with breast and gynaecological cancer, the excess does not appear to be strongly related to radiotherapy.
  • [MeSH-major] Hemangiosarcoma / epidemiology. Neoplasms / radiotherapy. Neoplasms, Radiation-Induced / epidemiology. Neoplasms, Second Primary / epidemiology. Radiotherapy / adverse effects

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  • (PMID = 17519906.001).
  • [ISSN] 0007-0920
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2359658
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45. Parekh J, Visser BC, Leong SP: Image of the month: angiosarcoma of the breast. Arch Surg; 2005 Aug;140(8):809-10
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  • [Title] Image of the month: angiosarcoma of the breast.
  • [MeSH-major] Breast Neoplasms / pathology. Carcinoma, Ductal, Breast / pathology. Hemangiosarcoma / pathology. Magnetic Resonance Imaging. Neoplasms, Second Primary / pathology

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  • (PMID = 16103292.001).
  • [ISSN] 0004-0010
  • [Journal-full-title] Archives of surgery (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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46. Rozen WM, Mann GB: Angiosarcoma arising in an unirradiated breast with subsequent pituitary metastasis. Clin Breast Cancer; 2007 Oct;7(10):811-3
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  • [Title] Angiosarcoma arising in an unirradiated breast with subsequent pituitary metastasis.
  • Angiosarcoma of the breast is a rare condition with known risk factors.
  • The Stewart-Treves syndrome describes angiosarcoma of the arm or breast in the setting of adjuvant radiation therapy (RT) after breast conservation surgery.
  • Angiosarcoma of the breast, in the absence of RT, is rarer still.
  • We present a unique case of angiosarcoma of the breast, diagnosed 6 years after conservative surgery for carcinoma of the breast when no adjuvant RT was given.
  • Chronic postoperative lymphoedema in the breast delayed the investigation of skin changes, with an eventual diagnosis of angiosarcoma.
  • An isolated pituitary metastasis 9 months from the diagnosis, the first such reported case, adds to the complexity of the case.
  • The diagnosis and management of angiosarcoma of the breast is discussed.
  • Angiosarcoma is a rare occurrence after breast conservative surgery.
  • Postoperative lymphoedema can impede early diagnosis.
  • [MeSH-major] Breast Neoplasms / pathology. Hemangiosarcoma / secondary. Neoplasms, Second Primary / pathology. Pituitary Neoplasms / secondary
  • [MeSH-minor] Carcinoma, Ductal, Breast / pathology. Carcinoma, Ductal, Breast / surgery. Female. Humans. Middle Aged. Neoplasms, Radiation-Induced / pathology

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  • (PMID = 18021485.001).
  • [ISSN] 1526-8209
  • [Journal-full-title] Clinical breast cancer
  • [ISO-abbreviation] Clin. Breast Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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47. Ricchetti T, Paci M, Cavazza A, Ferrari G, Annessi V, De Franco S, Sgarbi G: A case of metastatic epithelioid angiosarcoma in the lamina propria of a sigmoid tubulovillous adenoma. Tumori; 2005 Mar-Apr;91(2):210-2
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  • [Title] A case of metastatic epithelioid angiosarcoma in the lamina propria of a sigmoid tubulovillous adenoma.
  • Epithelioid angiosarcoma is an extremely rare tumor.
  • It is generally a secondary tumor and the preferred sites of such metastases are the heart, pericardium, lung, breast, liver, spleen, bone, and brain.
  • We report a case of epithelioid angiosarcoma with multiple bilateral lung infiltration, bone metastasis, and metastasis of the lamina propria of a tubulovillous adenoma of the colon.
  • [MeSH-major] Adenoma / pathology. Basement Membrane / pathology. Epithelioid Cells / pathology. Hemangiosarcoma / pathology. Hemangiosarcoma / secretion. Sigmoid Neoplasms / pathology

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  • (PMID = 15948556.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Platelet Endothelial Cell Adhesion Molecule-1
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48. Pfeiffer DF, Bode-Lesniewska B: Fine needle aspiration biopsy diagnosis of angiosarcoma after breast-conserving therapy for carcinoma supported by use of a cell block and immunohistochemistry. Acta Cytol; 2006 Sep-Oct;50(5):553-6
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  • [Title] Fine needle aspiration biopsy diagnosis of angiosarcoma after breast-conserving therapy for carcinoma supported by use of a cell block and immunohistochemistry.
  • BACKGROUND: Angiosarcoma is a rare malignant soft tissue tumor occurring at various sites as either a primary or secondary event.
  • Primary angiosarcoma of the breast is an unusual tumor, counting for 1 in 1700-2,000 primary malignant tumors of this organ.
  • An increasing number of secondary angiosarcomas involving skin and breast.
  • CASE: Angiosarcoma arose 6 years after breast-conserving therapy for invasive carcinoma in a 69-year-old woman.
  • Fine needle aspiration of several small, reddish, intradermal nodules over the treated area revealed malignant cells with an endothelial immunophenotype in the cel block, yielding the diagnosis of angiosarcoma, subsequently confired in a mastectomy speciman.
  • CONCLUSION: Fine needle aspiration, supported by ancillary techniques, such as cell block and immunohistochemistry, allows the cytologic diagnosis of an angiosarcoma and differentiates it from a carcinoma recurrence.
  • [MeSH-major] Breast / pathology. Breast Neoplasms / diagnosis. Carcinoma, Ductal, Breast / diagnosis. Hemangiosarcoma / diagnosis. Neoplasms, Second Primary / diagnosis. Radiotherapy / adverse effects
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Biomarkers, Tumor / metabolism. Biopsy, Fine-Needle. Cell Nucleus / pathology. Diagnosis, Differential. Epithelial Cells / pathology. Female. Humans. Immunohistochemistry / methods. Neoplasm Recurrence, Local / diagnosis

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  • (PMID = 17017445.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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49. Gatcombe HG, Olson TA, Esiashvili N: Metastatic primary angiosarcoma of the breast in a pediatric patient with a complete response to systemic chemotherapy and definitive radiation therapy: case report and review of the literature. J Pediatr Hematol Oncol; 2010 Apr;32(3):192-4
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  • [Title] Metastatic primary angiosarcoma of the breast in a pediatric patient with a complete response to systemic chemotherapy and definitive radiation therapy: case report and review of the literature.
  • We present a case of a rare malignancy, primary breast angiosarcoma, in a 15-year-old girl.
  • The patient was treated with systemic chemotherapy and definitive radiation therapy to her left breast and achieved a complete response.
  • She has no evidence of disease recurrence 44 months from her initial diagnosis.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bone Neoplasms / therapy. Breast Neoplasms / therapy. Hemangiosarcoma / therapy. Mediastinal Neoplasms / therapy. Radiotherapy

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  • (PMID = 20186104.001).
  • [ISSN] 1536-3678
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; UM20QQM95Y / Ifosfamide
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50. Patton KT, Deyrup AT, Weiss SW: Atypical vascular lesions after surgery and radiation of the breast: a clinicopathologic study of 32 cases analyzing histologic heterogeneity and association with angiosarcoma. Am J Surg Pathol; 2008 Jun;32(6):943-50
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  • [Title] Atypical vascular lesions after surgery and radiation of the breast: a clinicopathologic study of 32 cases analyzing histologic heterogeneity and association with angiosarcoma.
  • We report the clinicopathologic study of 32 cases of atypical vascular lesions (AVLs) after surgery and radiation of the breast, which were referred to us in consultation over a 17-year period.
  • Of the 21 patients, 17 are alive without disease, 1 is alive with disease, 1 died of breast carcinoma, 1 died of unknown causes, and 1 showed progressive histologic changes in the AVLs over a period of 5 years resulting in a well-differentiated angiosarcoma.
  • One patient underwent a mastectomy that revealed extensive residual AVL and the second developed a high-grade angiosarcoma after 14 months.
  • There seems to be an association of AVL with angiosarcoma that differs depending on the histologic features, with the VT AVLs having the higher risk.
  • In the 2 patients who developed angiosarcoma, morphologic evidence suggested AVLs to be a precursor rather than simply a risk factor.
  • [MeSH-major] Breast Neoplasms / pathology. Hemangiosarcoma / pathology. Neoplasms, Radiation-Induced / pathology

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  • (PMID = 18551753.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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51. Bernathova M, Jaschke W, Pechlahner C, Zelger B, Bodner G: Primary angiosarcoma of the breast associated Kasabach-Merritt syndrome during pregnancy. Breast; 2006 Apr;15(2):255-8
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  • [Title] Primary angiosarcoma of the breast associated Kasabach-Merritt syndrome during pregnancy.
  • Primary angiosarcoma of the breast is a rare aggressive tumour of unknown etiology.
  • A frequent clinical presentation is a painful palpable smooth mass or diffuse enlargement of the breast without a palpable mass but with purple discolouration of the overlying skin with apparent bruising.
  • An uncommon clinical presentation of an angiosarcoma is spontaneous bleeding due to disseminated intravascular coagulation (DIC) by consumption coagulopathy, known as the Kasabach-Merritt syndrome.
  • Imaging characteristics of a breast angiosarcoma are limited to a few radiological reports.
  • We report a case of a young pregnant woman with a bleeding angiosarcoma of the breast and associated Kasabach-Merritt syndrome and describe the sonographic and MRI findings.
  • [MeSH-major] Breast Neoplasms / diagnosis. Disseminated Intravascular Coagulation / diagnosis. Hemangiosarcoma / diagnosis. Pregnancy Complications, Hematologic / diagnosis. Pregnancy Complications, Neoplastic / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Pregnancy. Pregnancy Trimester, Second. Prenatal Diagnosis. Syndrome

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  • (PMID = 16000250.001).
  • [ISSN] 0960-9776
  • [Journal-full-title] Breast (Edinburgh, Scotland)
  • [ISO-abbreviation] Breast
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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52. Peramiquel L, Barnadas MA, Sancho J, Curell R, Alonso MC, Fuentes MJ, Pernas S, Gómez A, Alomar A: [Angiosarcoma in an irradiated breast: a case description]. Actas Dermosifiliogr; 2005 Nov;96(9):602-6
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  • [Title] [Angiosarcoma in an irradiated breast: a case description].
  • [Transliterated title] Angiosarcoma en mama irradiada: descripción de un caso.
  • Post-radiotherapy cutaneous angiosarcomas have been described in different locations, including the breast.
  • We present a case of cutaneous angiosarcoma of the breast, diagnosed 6 years after a carcinoma of the breast had been treated with radiation.
  • The patient was a 44-year-old female with a history of ductal carcinoma (CA) of the right breast treated with tumorectomy, axillary lymphadenectomy, chemotherapy (FEC) and radiotherapy, who 6 years later presented with a violaceous, indurated plaque with a satellite nodule on the same breast.
  • Considering the patient's symptoms, history and the changes observed via mammography, it was decided to completely excise the lesion followed by a simple mastectomy, with the diagnosis of angiosarcoma being confirmed.
  • Despite this fact, two years and one month later, the angiosarcoma recurred on the internal area of the mastectomy scar.
  • This complication usually appears 5-10 years after treatment with radiotherapy, so angiosarcoma should be ruled out if any angiomatous lesions later appear on skin that had been irradiated.
  • [MeSH-major] Breast Neoplasms / etiology. Breast Neoplasms / radiotherapy. Carcinoma, Ductal, Breast / radiotherapy. Hemangiosarcoma / etiology. Neoplasms, Radiation-Induced / etiology. Skin Neoplasms / etiology

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  • (PMID = 16476306.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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53. Poellinger A, Landt S, Diekmann F, Guski H, Bick U: Rapid growth of an exophytic angiosarcoma of the breast. Breast J; 2006 Jan-Feb;12(1):80-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Rapid growth of an exophytic angiosarcoma of the breast.
  • [MeSH-major] Breast Neoplasms / diagnosis. Hemangiosarcoma / diagnosis
  • [MeSH-minor] Aged. Aged, 80 and over. Carcinoma, Ductal, Breast / diagnosis. Carcinoma, Ductal, Breast / pathology. Carcinoma, Ductal, Breast / radiography. Carcinoma, Ductal, Breast / surgery. Diagnosis, Differential. Female. Humans. Mammography. Mastectomy

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  • (PMID = 16409594.001).
  • [ISSN] 1075-122X
  • [Journal-full-title] The breast journal
  • [ISO-abbreviation] Breast J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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54. West JG, Qureshi A, West JE, Chacon M, Sutherland ML, Haghighi B, Harrison J: Risk of angiosarcoma following breast conservation: a clinical alert. Breast J; 2005 Mar-Apr;11(2):115-23
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Risk of angiosarcoma following breast conservation: a clinical alert.
  • Approximately 100 cases of angiosarcoma following breast-conserving therapy have been reported.
  • The prevalence of angiosarcoma following breast conservation has not been accurately established and optimal treatment has not been defined.
  • The Fisher's exact test was used to compare the prevalence of postirradiation angiosarcoma seen in our private practice to the prevalence reported from the two largest national database studies.
  • The results of the comparison indicated that the prevalence of postirradiation angiosarcoma seen in our practice was significantly higher than that reported in the two national database studies at p-values of 0.0124 and 0.0080.
  • The data are insufficient to draw firm conclusions, but suggest that the current literature underestimates the prevalence of angiosarcoma following breast-conserving therapy.
  • Since elderly women derive less benefit from radiation and may be more prone to develop postirradiation angiosarcoma, confirmation of our findings could lead to a reappraisal of the management of elderly patients with early stage breast cancer.
  • [MeSH-major] Breast Neoplasms / epidemiology. Breast Neoplasms / therapy. Hemangiosarcoma / epidemiology. Hemangiosarcoma / etiology. Mastectomy, Segmental. Neoplasms, Radiation-Induced / epidemiology

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  • (PMID = 15730457.001).
  • [ISSN] 1075-122X
  • [Journal-full-title] The breast journal
  • [ISO-abbreviation] Breast J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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55. Styring E, Fernebro J, Jönsson PE, Ehinger A, Engellau J, Rissler P, Rydholm A, Nilbert M, Vult von Steyern F: Changing clinical presentation of angiosarcomas after breast cancer: from late tumors in edematous arms to earlier tumors on the thoracic wall. Breast Cancer Res Treat; 2010 Aug;122(3):883-7
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  • [Title] Changing clinical presentation of angiosarcomas after breast cancer: from late tumors in edematous arms to earlier tumors on the thoracic wall.
  • Angiosarcoma is a rare complication of breast cancer treatment.
  • In order to define predictors, clinical presentation, and outcome, we characterized a population-based 50-year cohort of angiosarcomas after breast cancer.
  • Clinical data were collected from all females with previous breast cancer who developed angiosarcomas/lymphangiosarcomas on the thoracic wall/upper extremity between 1958 and 2008 in the Southern Swedish health care region.
  • The patients formed two distinct groups; 14 females treated for breast cancer with radical mastectomy and radiotherapy 1949-1988 developed angiosarcomas in edematous arms (Stewart-Treves syndrome) after median 11 years, and 17 females treated by segmental resection, anti-hormonal treatment and radiotherapy 1980-2005 developed angiosarcomas in the irradiated field on the thoracic wall after median 7.3 years.
  • In this population-based cohort, the early angiosarcomas developed in edematous arms after radical mastectomies, whereas more recent cases occurred after a shorter time period in the irradiated fields following breast conserving surgery.
  • We conclude that the clinical presentation of angiosarcomas has changed, parallel with altered treatment principles for breast cancer.
  • [MeSH-major] Arm. Breast Neoplasms / therapy. Edema / etiology. Hemangiosarcoma / etiology. Neoplasm Recurrence, Local / etiology. Neoplasms, Second Primary / etiology. Thoracic Wall / pathology

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  • (PMID = 20087653.001).
  • [ISSN] 1573-7217
  • [Journal-full-title] Breast cancer research and treatment
  • [ISO-abbreviation] Breast Cancer Res. Treat.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
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56. Lvoff NM, Leung JW: Case of the season: primary angiosarcoma of the breast: correlative imaging and pathology. Semin Roentgenol; 2007 Oct;42(4):208-10
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  • [Title] Case of the season: primary angiosarcoma of the breast: correlative imaging and pathology.
  • [MeSH-major] Breast Neoplasms / diagnosis. Diagnostic Imaging. Hemangiosarcoma / diagnosis
  • [MeSH-minor] Adult. Contrast Media. Diagnosis, Differential. Female. Humans. Mastectomy, Radical

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  • (PMID = 17919522.001).
  • [ISSN] 0037-198X
  • [Journal-full-title] Seminars in roentgenology
  • [ISO-abbreviation] Semin Roentgenol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
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57. Shin SJ, Lesser M, Rosen PP: Hemangiomas and angiosarcomas of the breast: diagnostic utility of cell cycle markers with emphasis on Ki-67. Arch Pathol Lab Med; 2007 Apr;131(4):538-44
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  • [Title] Hemangiomas and angiosarcomas of the breast: diagnostic utility of cell cycle markers with emphasis on Ki-67.
  • CONTEXT: Vascular tumors comprise a minor subgroup of tumors arising in the breast and represent variants of hemangiomas and angiosarcomas.
  • OBJECTIVE: To investigate the utility of Ki-67 and other cell cycle regulatory proteins (S-phase kinase-associated protein 2 [Skp2], p27, and cyclin D1) in the differential diagnosis of mammary vascular lesions.
  • DESIGN: Thirty-four vascular tumors (21 hemangiomas and 13 angiosarcomas) of the breast were studied.
  • CONCLUSIONS: Ki-67 index can be used as a diagnostic tool to distinguish between benign and malignant vascular lesions of the breast.
  • This can be particularly helpful in cases of histologic overlap such as low-grade angiosarcoma and hemangioma.
  • [MeSH-major] Breast Neoplasms / diagnosis. Breast Neoplasms, Male / diagnosis. Hemangioma / diagnosis. Hemangiosarcoma / diagnosis. Ki-67 Antigen / metabolism
  • [MeSH-minor] Biomarkers, Tumor / analysis. Cell Cycle. Cyclin D1 / metabolism. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Middle Aged. Proliferating Cell Nuclear Antigen / metabolism. S-Phase Kinase-Associated Proteins / metabolism. Sensitivity and Specificity


58. Vorburger SA, Xing Y, Hunt KK, Lakin GE, Benjamin RS, Feig BW, Pisters PW, Ballo MT, Chen L, Trent J 3rd, Burgess M, Patel S, Pollock RE, Cormier JN: Angiosarcoma of the breast. Cancer; 2005 Dec 15;104(12):2682-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma of the breast.
  • BACKGROUND: Angiosarcoma of the breast is a rare entity.
  • METHODS: Clinical and pathologic factors were analyzed in all patients with angiosarcoma of the breast treated between 1990 and 2003.
  • RESULTS: Fifty-five women with angiosarcoma of the breast were identified.
  • For the 32 patients with primary angiosarcoma of the breast 5-year OS was 59%.
  • Twenty-three (42%) patients had received prior radiation therapy for the treatment of breast cancer.
  • These patients with radiation therapy-associated angiosarcoma were on average 30 years older and less likely to present with distant metastatic disease than patients presenting with radiation-naive angiosarcoma of the breast.
  • CONCLUSIONS: In this series of 55 patients with angiosarcoma of the breast, radiation therapy-naive angiosarcomas occurred in younger patients, but they behaved similarly to radiation therapy-associated angiosarcomas.
  • [MeSH-major] Breast Neoplasms / mortality. Breast Neoplasms / therapy. Hemangiosarcoma / mortality. Hemangiosarcoma / therapy. Mastectomy / methods

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  • [Copyright] Copyright 2005 American Cancer Society.
  • (PMID = 16288486.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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59. Vourtsi A, Zervoudis S, Pafiti A, Athanasiadis S: Male breast hemangioma--a rare entity: a case report and review of the literature. Breast J; 2006 May-Jun;12(3):260-2
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  • [Title] Male breast hemangioma--a rare entity: a case report and review of the literature.
  • We report the case of a 77-year-old man with a very rare breast tumor: hemangioma.
  • The histology confirmed the diagnosis of benign hemangioma.
  • Generally hemangiomas are large and ultrasound and magnetic resonance imaging (MRI) are useful for the diagnosis.
  • The important differential diagnosis with angiosarcoma is based on specific histologic patterns.
  • [MeSH-major] Breast Neoplasms, Male / diagnosis. Hemangioma / diagnosis


60. Ji J, Hemminki K: Familial blood vessel tumors and subsequent cancers. Ann Oncol; 2007 Jul;18(7):1260-7
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  • Offspring angiosarcoma in the trunk and extremities was associated with maternal breast cancer.
  • Similarly, offspring angiosarcoma is associated with maternal breast cancer.

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  • (PMID = 17426058.001).
  • [ISSN] 0923-7534
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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61. Rodríguez-Bujaldón A, Vázquez-Bayo MC, Galán-Gutiérrez M, Jiménez-Puya R, Vélez García-Nieto A, Moreno-Giménez JC, Vidal-Jiménez A, Barroso-Casamitjana E: [Angiosarcoma in chronic lymphedema]. Actas Dermosifiliogr; 2006 Oct;97(8):525-8
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  • [Title] [Angiosarcoma in chronic lymphedema].
  • [Transliterated title] Angiosarcoma sobre linfedema crónico.
  • Angiosarcoma that develops on a limb with chronic lymphedema is called Stewart-Treves syndrome.
  • This typically appears as a complication of a long course lymphedema located on the arm, after mastectomy and/or radiotherapy due to breast cancer.
  • There are cases of Stewart-Treves syndrome in chronic lymphedema in the upper limb contralateral to the breast treated for cancer and in chronic lymphedema of the leg.
  • The first corresponds to a typical syndrome of Stewart-Treves in an 83-year-old woman who was diagnosed of angiosarcoma in a chronic lymphedema territory secondary to mastectomy and radiotherapy due to breast cancer.
  • The second case is much rarer, since it is a case of diffuse angiosarcoma of the leg in a 42-year-old man with a history of lymphedema.
  • [MeSH-major] Hemangiosarcoma / etiology. Lymphedema / complications
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antibiotics, Antineoplastic / administration & dosage. Antibiotics, Antineoplastic / therapeutic use. Antineoplastic Agents, Alkylating / administration & dosage. Antineoplastic Agents, Alkylating / therapeutic use. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Arm. Doxorubicin / administration & dosage. Doxorubicin / therapeutic use. Female. Humans. Ifosfamide / administration & dosage. Ifosfamide / therapeutic use. Immunohistochemistry. Leg. Male. Skin / pathology. Skin Neoplasms / diagnosis. Skin Neoplasms / drug therapy. Skin Neoplasms / etiology. Skin Neoplasms / pathology. Skin Neoplasms / radiotherapy. Treatment Outcome

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  • (PMID = 17067532.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Antineoplastic Agents, Alkylating; 80168379AG / Doxorubicin; UM20QQM95Y / Ifosfamide
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62. Salameire D, Templier I, Charles J, Pinel N, Morand P, Leccia MT, Lantuejoul S: An "anaplastic" Kaposi's sarcoma mimicking a Stewart-Treves syndrome. A case report and a review of literature. Am J Dermatopathol; 2008 Jun;30(3):265-8
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  • Cutaneous angiosarcoma (AGS) developing in a lymphedematous arm, after lymphadenectomy in the context of breast cancer, is the definition of the classical Stewart-Treves syndrome.
  • The final diagnosis was an "anaplastic" KS mimicking a Stewart-Treves syndrome.
  • [MeSH-major] Hemangiosarcoma / diagnosis. Lymphangiosarcoma / diagnosis. Lymphedema / pathology. Sarcoma, Kaposi / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. DNA, Neoplasm / analysis. Diagnosis, Differential. Female. Herpesvirus 8, Human / isolation & purification. Humans. Middle Aged. Syndrome. Viral Proteins / metabolism

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  • (PMID = 18496429.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / Viral Proteins; 0 / assembly protein, Human herpesvirus 8
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63. Shin DH, Lee MH, Kim DY, Lee KJ, Park JY, Ahn SH, Han KH, Chon CY: [A case of hepatic congestion due to right heart failure mimicking liver tumor]. Korean J Gastroenterol; 2010 Oct;56(4):264-7
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  • The patient had a history of breast cancer and left total mastectomy 30 years ago, tricuspid valve regurgitation and tricuspid valve replacement 4 years ago.
  • In magnetic resonance imaging (MRI), numerous variable sized ill-defined nodules replacing entire liver with progressing centripetal enhancement, which were suggestive of malignancy such as angiosarcoma, were noted.
  • MRI finding suspects malignancy or hemangiosarcoma.
  • [MeSH-major] Heart Failure / complications. Liver Diseases / diagnosis
  • [MeSH-minor] Biopsy, Needle. Female. Humans. Liver Neoplasms / diagnosis. Magnetic Resonance Imaging. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 20962564.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Korea (South)
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64. Solin LJ, Fourquet A, Vicini FA, Taylor M, Haffty B, Strom EA, Wai E, Pierce LJ, Marks LB, Bartelink H, Campana F, McNeese MD, Jhingran A, Olivotto IA, Bijker N, Hwang WT: Salvage treatment for local or local-regional recurrence after initial breast conservation treatment with radiation for ductal carcinoma in situ. Eur J Cancer; 2005 Aug;41(12):1715-23
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  • [Title] Salvage treatment for local or local-regional recurrence after initial breast conservation treatment with radiation for ductal carcinoma in situ.
  • The present study evaluated the outcome of salvage treatment for women with local or local-regional recurrence after initial breast conservation treatment with radiation for mammographically detected ductal carcinoma in situ (DCIS; intraductal carcinoma) of the breast.
  • The histology at the time of recurrence was invasive carcinoma for 53 patients (59%), non-invasive carcinoma for 34 patients (38%), angiosarcoma for one patient (1%), and unknown for two patients (2%).
  • Close follow-up after initial breast conservation treatment with radiation is warranted for the early detection of potentially salvageable local and local-regional recurrences.
  • [MeSH-major] Breast Neoplasms / surgery. Carcinoma, Intraductal, Noninfiltrating / surgery. Mastectomy, Segmental / methods. Neoplasm Recurrence, Local / surgery. Salvage Therapy / methods

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  • (PMID = 16043350.001).
  • [ISSN] 0959-8049
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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65. Tomasello L, Gardin G, Boccardo F: Secondary breast angiosarcoma: lethal response to anti-angiogenic therapy with paclitaxel chemotherapy. A case report. Anticancer Res; 2006 Nov-Dec;26(6C):4775-7
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  • [Title] Secondary breast angiosarcoma: lethal response to anti-angiogenic therapy with paclitaxel chemotherapy. A case report.
  • Angiosarcoma of the breast is a malignant tumour of vascular endothelial cells.
  • The authors report a case of cutaneous radiation-associated angiosarcoma treated with paclitaxel chemotherapy.
  • [MeSH-major] Breast Neoplasms / chemically induced. Hemangiosarcoma / chemically induced. Neoplasms, Second Primary / chemically induced. Paclitaxel / adverse effects
  • [MeSH-minor] Aged, 80 and over. Carcinoma, Ductal, Breast / drug therapy. Carcinoma, Ductal, Breast / pathology. Female. Humans

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  • (PMID = 17214340.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] P88XT4IS4D / Paclitaxel
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66. Requena L, Santonja C, Stutz N, Kaddu S, Weenig RH, Kutzner H, Menzel T, Cerroni L: Pseudolymphomatous cutaneous angiosarcoma: a rare variant of cutaneous angiosarcoma readily mistaken for cutaneous lymphoma. Am J Dermatopathol; 2007 Aug;29(4):342-50
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  • [Title] Pseudolymphomatous cutaneous angiosarcoma: a rare variant of cutaneous angiosarcoma readily mistaken for cutaneous lymphoma.
  • Cutaneous angiosarcoma is probably the most malignant neoplasm involving the skin.
  • Three clinical variants of cutaneous angiosarcoma are recognized, including angiosarcoma of the scalp and face of elderly patients, angiosarcoma associated with chronic lymphedema, and postirradiation angiosarcoma.
  • Histopathologically, these three variants of angiosarcoma show similar features, which consist of poorly circumscribed, irregularly dilated, and anastomosing vascular channels lined by prominent endothelial cells that dissect through the dermis.
  • Cutaneous angiosarcoma with prominent lymphocytic infiltrate may be readily mistaken for cutaneous follicle center cell lymphoma or cutaneous pseudolymphoma.
  • [MeSH-major] Hemangiosarcoma / diagnosis. Lymphoma / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged. Breast Neoplasms / diagnosis. Diagnosis, Differential. Endothelial Cells / pathology. Endothelium, Vascular / pathology. Facial Neoplasms / diagnosis. Female. Humans. Lymphocytes / pathology. Lymphoma, Follicular / diagnosis. Male. Middle Aged. Neovascularization, Pathologic / pathology. Pseudolymphoma / diagnosis. Scalp / pathology. Skin Diseases / diagnosis

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  • (PMID = 17667166.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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67. Liu H, Zhao J, Fan Y, Fu XL, Fu L: [Clinical and pathologic characteristics of primary angiosarcoma of breast]. Zhonghua Bing Li Xue Za Zhi; 2006 Oct;35(10):598-601
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  • [Title] [Clinical and pathologic characteristics of primary angiosarcoma of breast].
  • OBJECTIVE: To study the clinical and pathologic characteristics of primary angiosarcoma of breast.
  • METHODS: Five cases of primary angiosarcoma of breast were reviewed.
  • RESULTS: All of the 5 patients had a history of a painless breast lump.
  • CONCLUSIONS: Primary angiosarcoma of breast is a rare entity.
  • The diagnosis is rather difficult owing to the lack of specific clinical findings and histological heterogeneity.
  • Application of Positive expression of endothelial associated antigens of the tumors cells is helpful in making a pathological diagnosis morphologically.
  • [MeSH-major] Breast Neoplasms / pathology. Breast Neoplasms, Male / pathology. Hemangiosarcoma / pathology
  • [MeSH-minor] Adult. Antigens, CD31 / metabolism. Antigens, CD34 / metabolism. Breast / metabolism. Breast / pathology. Breast / surgery. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Immunohistochemistry. Male. Mastectomy / methods. Middle Aged. von Willebrand Factor / metabolism

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  • (PMID = 17134567.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Antigens, CD34; 0 / von Willebrand Factor
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68. Fujita T, Taira N, Ogasawara Y, Omori M, Doihara H: Bilateral angiosarcoma of the breast detected by magnetic resonance imaging during pregnancy. Int J Clin Oncol; 2009 Dec;14(6):560-3
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  • [Title] Bilateral angiosarcoma of the breast detected by magnetic resonance imaging during pregnancy.
  • Angiosarcoma of the breast is an aggressive malignancy of endothelial origin with a tendency for local regional recurrence.
  • Of note, due to its rarity and typically unclear clinical findings upon examination, the diagnosis of a contralateral lesion can be difficult, particularly in women during pregnancy.
  • Here we present a rare case of bilateral angiosarcoma of the breast during pregnancy.
  • A 32-year-old woman was referred to our unit with complaints of progressive swelling of the left breast, with tenderness.
  • Magnetic resonance imaging showed a small, circumscribed high-intensity area in the contralateral breast, with pattern similar to that of the lesion found in the left breast.
  • Diagnosed as angiosarcoma preoperatively, excision of the bilateral tumors was performed.
  • Histological findings of the removed bilateral tumors were compatible with high-grade angiosarcoma of the breast.
  • [MeSH-major] Breast Neoplasms / diagnosis. Hemangiosarcoma / diagnosis. Magnetic Resonance Imaging. Mammary Glands, Human / pathology. Pregnancy Complications, Neoplastic / diagnosis


69. Penel N, Bui BN, Bay JO, Cupissol D, Ray-Coquard I, Piperno-Neumann S, Kerbrat P, Fournier C, Taieb S, Jimenez M, Isambert N, Peyrade F, Chevreau C, Bompas E, Brain EG, Blay JY: Phase II trial of weekly paclitaxel for unresectable angiosarcoma: the ANGIOTAX Study. J Clin Oncol; 2008 Nov 10;26(32):5269-74
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  • [Title] Phase II trial of weekly paclitaxel for unresectable angiosarcoma: the ANGIOTAX Study.
  • PURPOSE: The objective of this phase II trial was to assess the efficacy and toxicity of weekly paclitaxel for patients with metastatic or unresectable angiosarcoma.
  • Three patients with locally advanced breast angiosarcoma presented partial response, which enabled a secondary curative-intent surgery with complete histologic response in two cases.
  • [MeSH-major] Antineoplastic Agents, Phytogenic / administration & dosage. Breast Neoplasms / drug therapy. Head and Neck Neoplasms / drug therapy. Hemangiosarcoma / drug therapy. Paclitaxel / administration & dosage. Scalp. Skin Neoplasms / drug therapy. Soft Tissue Neoplasms / drug therapy

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  • (PMID = 18809609.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; P88XT4IS4D / Paclitaxel
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70. Di Tommaso L, Rosai J: The capillary lobule: a deceptively benign feature of post-radiation angiosarcoma of the skin: report of three cases. Am J Dermatopathol; 2005 Aug;27(4):301-5
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  • [Title] The capillary lobule: a deceptively benign feature of post-radiation angiosarcoma of the skin: report of three cases.
  • Three cases are presented of a proliferative vascular lesion of the skin developing in the chest wall of women who had received radiation therapy for breast carcinoma.
  • All 3 lesions were characterized microscopically by the presence of the so-called capillary lobule, a formation generally regarded as a sign of benignancy but that in this setting proved to be a forerunner or indicator of angiosarcoma (malignant hemangioendothelioma).
  • Therefore, the detection of capillary lobules in irradiated skin ought to be regarded with great suspicion, and other morphologic signs suggestive of angiosarcoma should be sought in the specimen.
  • [MeSH-major] Hemangiosarcoma / pathology. Neoplasms, Radiation-Induced / pathology. Neoplasms, Second Primary / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Breast Neoplasms / therapy. Female. Humans

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  • [CommentIn] Am J Dermatopathol. 2006 Aug;28(4):376 [16871048.001]
  • (PMID = 16121049.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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71. Campone M, Levy V, Bourbouloux E, Berton Rigaud D, Bootle D, Dutreix C, Zoellner U, Shand N, Calvo F, Raymond E: Safety and pharmacokinetics of paclitaxel and the oral mTOR inhibitor everolimus in advanced solid tumours. Br J Cancer; 2009 Jan 27;100(2):315-21
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  • A total of 16 patients (median age 54.5 years, range 33-69) were entered; 11 had prior taxane therapy for breast (n=5), ovarian (n=3), and vaginal cancer (n=1) or angiosarcoma (n=2).
  • Tumour stabilisation reported in 11 patients exceeded 6 months in 2 patients with breast cancer.

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  • (PMID = 19127256.001).
  • [ISSN] 1532-1827
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 9HW64Q8G6G / Everolimus; EC 2.7.- / Protein Kinases; EC 2.7.1.1 / MTOR protein, human; EC 2.7.1.1 / TOR Serine-Threonine Kinases; P88XT4IS4D / Paclitaxel; W36ZG6FT64 / Sirolimus
  • [Other-IDs] NLM/ PMC2634724
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72. Wang XY, Jakowski J, Tawfik OW, Thomas PA, Fan F: Angiosarcoma of the breast: a clinicopathologic analysis of cases from the last 10 years. Ann Diagn Pathol; 2009 Jun;13(3):147-50
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  • [Title] Angiosarcoma of the breast: a clinicopathologic analysis of cases from the last 10 years.
  • Breast angiosarcoma may occur de novo, or as a complication of radiation therapy, or chronic lymphedema secondary to axillary lymph node dissection for mammary carcinoma.
  • In our effort to characterize the clinicopathologic features of breast angiosarcoma, we reviewed all breast angiosarcoma cases in the University of Kansas Medical Center and Ohio State University Medical Center archives from 1997 to 2007.
  • Only 11 angiosarcomas were identified among more than 5000 malignant breast neoplasms (0.1%-0.2% incidence) for the last 10 years.
  • Eight cases (6 high grade, 1 intermediate grade, 1 low grade) were identified as postradiation angiosarcoma (postradiation time interval, 4-12 years), and 3 cases were identified as primary angiosarcomas (1 high grade, 2 low grade).
  • Follow-up (median, 36 months) revealed that 3 cases of postradiation angiosarcoma recurred as skin and/or chest wall lesions and 1 case of primary angiosarcoma developed liver metastases (all high-grade).
  • In conclusion, breast angiosarcoma remains a rare disease.
  • Rosen's method for grading breast angiosarcoma is easy to implement and correlates well with clinical outcome.
  • There are no distinct clinical or histologic differences between primary and postradiation breast angiosarcomas.
  • [MeSH-major] Breast Neoplasms / pathology. Hemangiosarcoma / pathology

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  • (PMID = 19433291.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 12
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73. Gagnon PJ, Galderisi C, Page BR, Holland JM: Angiosarcoma developing after curative induction chemotherapy and radiotherapy for locally advanced squamous cell carcinoma of the larynx. Head Neck; 2009 Jun;31(6):829-32
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  • [Title] Angiosarcoma developing after curative induction chemotherapy and radiotherapy for locally advanced squamous cell carcinoma of the larynx.
  • BACKGROUND: Angiosarcoma arising after radiation is described in breast cancer but occurs elsewhere.
  • Here, we present an angiosarcoma of the neck occurring after curative chemoradiation.
  • METHODS: This is a case of angiosarcoma developing 5 years after curative therapy for T3N0 squamous cell carcinoma of the supraglottic larynx.
  • Examination showed a 7-cm mass and biopsy revealed angiosarcoma.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / adverse effects. Carcinoma, Squamous Cell / therapy. Hemangiosarcoma / etiology. Laryngeal Neoplasms / therapy. Radiotherapy, High-Energy / adverse effects. Skin Neoplasms / etiology

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  • [Copyright] (c) 2008 Wiley Periodicals, Inc.
  • (PMID = 18853452.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] P88XT4IS4D / Paclitaxel
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74. Takenaka M, Tanaka M, Isobe M, Yamaguchi R, Kojiro M, Shirouzu K: Angiosarcoma of the breast with silicone granuloma: a case report. Kurume Med J; 2009;56(1-2):33-7
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  • [Title] Angiosarcoma of the breast with silicone granuloma: a case report.
  • Angiosarcoma of the breast is a rare non-epithelial tumor and that accounts for less than 0.1% of primary malignancies of the breast.
  • The disease has a relatively higher occurrence among young people, and its prognosis (3-year-survival of only 38%) is extremely poor compared to breast cancer.
  • Here we present a case of an 87-year-old woman who had undergone bilateral breast augmentation with silicone injections in her youth.
  • Although she became aware of a tumor in her right breast, she waited 8 years before seeking treatment.
  • Two years later she was brought to our hospital by ambulance for continuous bleeding from the same tumor of the breast, which by that time was over 11 cm in diameter.
  • The histological diagnosis was angiosarcoma of the breast with silicone granuloma.
  • [MeSH-major] Breast Implantation / adverse effects. Breast Neoplasms / etiology. Hemangiosarcoma / etiology. Silicone Gels / adverse effects

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  • (PMID = 20103999.001).
  • [ISSN] 1881-2090
  • [Journal-full-title] The Kurume medical journal
  • [ISO-abbreviation] Kurume Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Silicone Gels
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75. Weaver J, Billings SD: Postradiation cutaneous vascular tumors of the breast: a review. Semin Diagn Pathol; 2009 Aug;26(3):141-9
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  • [Title] Postradiation cutaneous vascular tumors of the breast: a review.
  • (1) postradiation cutaneous angiosarcoma, malignant vascular neoplasms with significant morbidity and mortality; and (2) atypical vascular lesions (AVL), vascular tumors that reportedly behave in a benign manner.
  • Although first described separately 15 years ago, the relationship between postradiation cutaneous angiosarcoma and AVL remains controversial.
  • It appears that, in at least some cases, angiosarcoma can arise in the context of AVL, suggesting that these lesions are part of a spectrum of the same disease process.
  • Herein, we will discuss the evolution of this topic while reviewing the various clinical, histopathologic, and prognostic characteristics of postradiation cutaneous angiosarcoma and AVL.
  • [MeSH-major] Breast Neoplasms / radiotherapy. Hemangiosarcoma / pathology. Neoplasms, Radiation-Induced / pathology. Skin Neoplasms / pathology

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  • (PMID = 20043513.001).
  • [ISSN] 0740-2570
  • [Journal-full-title] Seminars in diagnostic pathology
  • [ISO-abbreviation] Semin Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 21
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76. Perez-Ruiz E, Ribelles N, Sanchez-Muñoz A, Roman A, Marquez A: Response to paclitaxel in a radiotherapy-induced breast angiosarcoma. Acta Oncol; 2009;48(7):1078-9
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  • [Title] Response to paclitaxel in a radiotherapy-induced breast angiosarcoma.
  • [MeSH-major] Antineoplastic Agents, Phytogenic / therapeutic use. Breast Neoplasms / drug therapy. Breast Neoplasms / radiotherapy. Carcinoma, Ductal, Breast / radiotherapy. Hemangiosarcoma / drug therapy. Neoplasms, Radiation-Induced / drug therapy. Paclitaxel / therapeutic use

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  • (PMID = 19235566.001).
  • [ISSN] 1651-226X
  • [Journal-full-title] Acta oncologica (Stockholm, Sweden)
  • [ISO-abbreviation] Acta Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; P88XT4IS4D / Paclitaxel
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77. Sanz C, Moreno F, Armas A, Casado A, Castillo MC: Groin angiosarcoma following radiotherapy for vulvar cancer. Gynecol Oncol; 2005 May;97(2):677-80
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  • [Title] Groin angiosarcoma following radiotherapy for vulvar cancer.
  • However, they represent 15% of radiotherapy-induced sarcomas, usually associated to the treatment for breast cancer, cervical cancer, and lymphomas.
  • CASE REPORT: We report the case of a 56-year-old patient who developed a soft tissue angiosarcoma in the right groin 25 years after receiving radiotherapy for vulvar cancer.
  • To our knowledge, this is the second case reported of a soft tissue angiosarcoma after radiotherapy for a vulvar cancer.
  • [MeSH-major] Hemangiosarcoma / etiology. Neoplasms, Radiation-Induced / etiology. Vulvar Neoplasms / radiotherapy

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  • (PMID = 15863181.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 14
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78. Raina V, Sengar M, Shukla NK, Deo SS, Mohanty BK, Sharma D, Ray R, Das P, Rath GK: Complete response from thalidomide in angiosarcoma after treatment of breast cancer. J Clin Oncol; 2007 Mar 1;25(7):900-1
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  • [Title] Complete response from thalidomide in angiosarcoma after treatment of breast cancer.
  • [MeSH-major] Breast Neoplasms / drug therapy. Hemangiosarcoma / drug therapy. Thalidomide / therapeutic use

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  • (PMID = 17327613.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 4Z8R6ORS6L / Thalidomide
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79. Kiyozuka Y, Koyama H, Nakata M, Matsuyama T, Nikaido Y, Shimano N, Tsubura A: Diagnostic cytopathology in type II angiosarcoma of the breast: a case report. Acta Cytol; 2005 Sep-Oct;49(5):560-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnostic cytopathology in type II angiosarcoma of the breast: a case report.
  • BACKGROUND: The rare occurrence of angiosarcoma of the breast is reflected in limited descriptions of fine needle aspiration (FNA) cytomorphologic findings in this neoplasm.
  • We present a case of angiosarcoma of the breast and discuss the pitfalls in diagnostic cytopathology that can potentially lead to incorrect diagnoses in such cases.
  • CASE: A 45-year-old woman presented with a 2-year history of a right-sided breast mass.
  • The overall cytologic diagnosis was inconclusive but suggested phyllodes tumor (of borderline malignancy).
  • Histologic features were consistent with angiosarcoma, a diagnosis that was supported by immunohistochemical studies.
  • Angiosarcoma rarely occurs in the breast, and a definitive diagnosis is difficult based on cytologic examination of hypocellular smears alone.
  • [MeSH-major] Blood Vessels / pathology. Breast Neoplasms / pathology. Hemangiosarcoma / pathology. Mammary Glands, Human / blood supply. Mammary Glands, Human / pathology

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  • (PMID = 16334037.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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80. Pernas Simon S, Fuentes Raspall MJ, de Andrés Basauri L, Barnadas Andiñach MA: [Breast angiosarcoma after conservative treatment for breast carcinoma]. Med Clin (Barc); 2005 Apr 9;124(13):515
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  • [Title] [Breast angiosarcoma after conservative treatment for breast carcinoma].
  • [Transliterated title] Angiosarcoma de mama tras tratamiento conservador en cáncer de mama.
  • [MeSH-major] Breast Neoplasms / pathology. Hemangiosarcoma / pathology. Neoplasms, Second Primary / pathology
  • [MeSH-minor] Aged. Antigens, CD31 / immunology. Antigens, CD34 / immunology. Carcinoma, Ductal, Breast / pathology. Carcinoma, Ductal, Breast / radiotherapy. Carcinoma, Ductal, Breast / surgery. Female. Humans. Immunohistochemistry. Neoplasm Recurrence, Local. Neoplasm Staging. Time Factors

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  • (PMID = 15847772.001).
  • [ISSN] 0025-7753
  • [Journal-full-title] Medicina clínica
  • [ISO-abbreviation] Med Clin (Barc)
  • [Language] spa
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Antigens, CD34
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81. Ortiz Mendoza CM: [Recurrent breast haematoma after fine needle aspiration biopsy of angiosarcoma]. Ginecol Obstet Mex; 2007 Mar;75(3):164-7
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  • [Title] [Recurrent breast haematoma after fine needle aspiration biopsy of angiosarcoma].
  • [Transliterated title] Hematoma mamario recidivante posterior a la biopsia por aspiración con aguja delgada en un angiosarcoma.
  • It is reported a rare complication after a fine needle aspiration biopsy of a breast angiosarcoma.
  • A 30-years-old female presented with a right breast lump.
  • A fine needle aspiration biopsy was carried out for diagnosis, but only blood was report.
  • A capillary and cavernous breast hemangioma was diagnosed.
  • Four months later a recurrence presented, and a new excision was carried out with a resulting moderately differentiated angiosarcoma, then a simple mastectomy was performed for definitive treatment.
  • A recurrent haematoma after a fine needle aspiration biopsy of a breast tumor mandates to rule out an angiosarcoma.
  • [MeSH-major] Biopsy, Fine-Needle / adverse effects. Breast / injuries. Breast Neoplasms / pathology. Hemangiosarcoma / pathology. Hematoma / etiology

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  • (PMID = 17547091.001).
  • [ISSN] 0300-9041
  • [Journal-full-title] Ginecología y obstetricia de México
  • [ISO-abbreviation] Ginecol Obstet Mex
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Mexico
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82. Moe M, Bertelli G: Breast angiosarcoma following lumpectomy and radiotherapy for breast cancer: a case with short latent period and false negative result on biopsies. Ann Oncol; 2007 Apr;18(4):801
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Breast angiosarcoma following lumpectomy and radiotherapy for breast cancer: a case with short latent period and false negative result on biopsies.

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  • [CommentIn] Ann Oncol. 2007 Apr;18(4):619-21 [17351257.001]
  • (PMID = 17229767.001).
  • [ISSN] 0923-7534
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Letter
  • [Publication-country] England
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83. Nascimento AF, Raut CP, Fletcher CD: Primary angiosarcoma of the breast: clinicopathologic analysis of 49 cases, suggesting that grade is not prognostic. Am J Surg Pathol; 2008 Dec;32(12):1896-904
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary angiosarcoma of the breast: clinicopathologic analysis of 49 cases, suggesting that grade is not prognostic.
  • Mammary angiosarcoma is a rare neoplasm, accounting for about 0.05% of all primary malignancies of the breast.
  • Forty-nine cases of primary angiosarcoma of the breast were retrieved from our files.
  • All tumors examined were located within breast parenchyma with or without minor cutaneous involvement.
  • Two patients had a history of prior radiation treatment for breast carcinoma.
  • Ten patients (24.4%) showed evidence of local recurrence within 11 to 60 months (median 36) after diagnosis.
  • Time interval between diagnosis and metastasis ranged from 2 to 144 months (median 34).
  • Eighteen patients (44%) so far have died of disease and 1 died of presumably disseminated breast carcinoma.
  • In conclusion, mammary angiosarcoma is a rare disease that affects relatively younger patients.
  • This tumor seems to have an overall similar clinical course as other types of angiosarcoma arising in skin or soft tissue; it carries a moderate risk of local recurrence, and a high risk of metastasis and death.
  • [MeSH-major] Breast Neoplasms / pathology. Hemangiosarcoma / pathology

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  • (PMID = 18813119.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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84. Losanoff JE, Jaber S, Esuba M, Perry M, Sauter ER: Primary angiosarcoma of the breast: do enlarged axillary nodes matter? Breast J; 2006 Jul-Aug;12(4):371-4
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  • [Title] Primary angiosarcoma of the breast: do enlarged axillary nodes matter?
  • Primary angiosarcoma of the breast is a rare and aggressive malignancy that is typically seen in premenopausal patients.
  • We present a case of breast angiosarcoma presenting with enlarged axillary lymph nodes treated with a modified mastectomy and axillary lymph node dissection.
  • [MeSH-major] Breast Neoplasms / pathology. Hemangiosarcoma / pathology. Lymph Nodes / pathology

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  • (PMID = 16848851.001).
  • [ISSN] 1075-122X
  • [Journal-full-title] The breast journal
  • [ISO-abbreviation] Breast J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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85. Hodgson NC, Bowen-Wells C, Moffat F, Franceschi D, Avisar E: Angiosarcomas of the breast: a review of 70 cases. Am J Clin Oncol; 2007 Dec;30(6):570-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcomas of the breast: a review of 70 cases.
  • OBJECTIVE: Angiosarcoma arising in the irradiated breast after breast-conserving therapy is being reported with increasing frequency.
  • As more women undergo breast-conserving therapy, the incidence can be expected to increase.
  • The objective of this study was to review breast angiosarcomas diagnosed from 1981 to 2000 from our state cancer registry.
  • METHODS: A comprehensive review of a population-based registry, Florida Cancer Data System, identified 70 cases of breast angiosarcomas from 1981 to 2000.
  • RESULTS: Of the 70 cases at presentation, 39 were primary breast angiosarcomas (PBAs) and 31 were secondary breast angiosarcomas (SBAs).
  • In the SBA group the mean age of breast cancer diagnosis was 67.6.
  • The mean time to diagnosis of the angiosarcoma was 5.2 years after breast cancer irradiation.
  • CONCLUSION: Angiosarcoma of the breast is rare and this study reports a review of 70 cases from 1980 to 2000.
  • Angiosarcoma after breast-conserving therapy is increasingly diagnosed in a small but significant portion of breast carcinoma survivors.
  • [MeSH-major] Breast Neoplasms / etiology. Hemangiosarcoma / etiology. Mastectomy, Segmental / adverse effects. Neoplasms, Second Primary / etiology

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  • (PMID = 18091049.001).
  • [ISSN] 1537-453X
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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86. De Smet S, Vandermeeren L, Christiaens MR, Samson I, Stas M, Van Limbergen E, De Wever I: Radiation-induced sarcoma: analysis of 46 cases. Acta Chir Belg; 2008 Sep-Oct;108(5):574-9
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  • Eight male and 38 female patients had received radiotherapy, mainly for breast cancer and genitourinary tumours.
  • The interval between irradiation and the diagnosis of sarcoma ranged from 1 to 54 years (median 15 y).
  • Angiosarcoma and sarcoma non-otherwise-specified were the most common histological types.

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  • (PMID = 19051469.001).
  • [ISSN] 0001-5458
  • [Journal-full-title] Acta chirurgica Belgica
  • [ISO-abbreviation] Acta Chir. Belg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Belgium
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87. Dubner S, Bovi J, White J, Susnik B: Postirradiation morphea in a breast cancer patient. Breast J; 2006 Mar-Apr;12(2):173-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Postirradiation morphea in a breast cancer patient.
  • We present the case of a 52-year-old woman who underwent lumpectomy and radiation therapy for breast carcinoma and 2 years later presented with changes limited to the breast radiation field including hyperpigmentation, retraction, and skin thickening.
  • It is important to be aware of this rare complication of radiation therapy because it clinically presents with symptoms mimicking malignancy and may be misinterpreted as recurrent carcinoma or even angiosarcoma.
  • [MeSH-major] Breast Neoplasms / radiotherapy. Radiation Injuries / pathology. Scleroderma, Localized / etiology


88. Esler-Brauer L, Jaggernauth W, Zeitouni NC: Angiosarcoma developing after conservative treatment for breast carcinoma: case report with review of the current literature. Dermatol Surg; 2007 Jun;33(6):749-55
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma developing after conservative treatment for breast carcinoma: case report with review of the current literature.
  • [MeSH-major] Breast Neoplasms / etiology. Breast Neoplasms / radiotherapy. Carcinoma, Ductal, Breast / radiotherapy. Hemangiosarcoma / etiology. Neoplasms, Radiation-Induced / etiology. Neoplasms, Second Primary / etiology

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  • (PMID = 17550458.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 54
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89. Eilender D, LoRusso P, Thomas L, McCormick C, Rodgers AH, Hooper CL, Tornyos K, Krementz ET, Parker S, Morgan LR: 4,4'-Dihydroxybenzophenone-2,4-dinitrophenylhydrazone (A-007): a topical treatment for cutaneous metastases from malignant cancers. Cancer Chemother Pharmacol; 2006 Jun;57(6):719-26
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PATIENTS AND METHODS: This is a multicenter study involving 27 patients with inoperable skin lesions from histologically confirmed cancers of the breast and oral cavity, non-Hodgkin's lymphoma, Kaposi's sarcoma, and angiosarcoma that had failed radiotherapy or systemic treatment.
  • For patients with breast cancer, hormonal status did not have an impact on response.

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  • (PMID = 16184382.001).
  • [ISSN] 0344-5704
  • [Journal-full-title] Cancer chemotherapy and pharmacology
  • [ISO-abbreviation] Cancer Chemother. Pharmacol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA 16672; United States / NCI NIH HHS / CA / CA 49310; United States / NCI NIH HHS / CA / CA 89772
  • [Publication-type] Clinical Trial; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / 4,4'-dihydroxybenzophenone-2,4-dinitrophenylhydrazone; 0 / Antineoplastic Agents; 0 / Hydrazones; 0 / Phenols
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90. Magri K, Demoulin G, Millon G, Duvert B: [Metastasis to the breast from non mammary metastasis. Clinical, radiological characteristics and diagnostic process. A report of two cases and a review of literature]. J Gynecol Obstet Biol Reprod (Paris); 2007 Oct;36(6):602-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Metastasis to the breast from non mammary metastasis. Clinical, radiological characteristics and diagnostic process. A report of two cases and a review of literature].
  • [Transliterated title] Métastases au niveau des seins de tumeurs extramammaires. Caractéristiques cliniques, radiologiques et démarche diagnostique. A propos de deux cas et revue de la littérature.
  • The metastatic involvement of the breast from non-mammary neoplasms is a relatively rare condition: 0.5 to 6% of the breast cancers.
  • All cancers can give breast metastases, several months after the discovery of the primitive tumor or in 25% of the cases in being the first sign.
  • Their clinical and radiological presentation polymorphic installation a problem of differential diagnosis between benign tumor, like the fibroadenomas on the one hand, and malignant tumors of other share.
  • The presence of multiple, bilateral round tumors, superficial without the traditional signs of malignity which one meets with the primitive tumors: irregular margins, spiculations, microcalcifications, posterior cone of shadow is evocative diagnosis.
  • Pathologic examination completed with immunohistochemical tests is a key point for diagnosis.
  • The search for a primitive tumor is essential, in particular for neuroendocrine carcinoma, stromal sarcoma, and the angiosarcoma which can be primitive tumors of the breast.
  • [MeSH-major] Breast Neoplasms / secondary
  • [MeSH-minor] Aged. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Brain Neoplasms / diagnosis. Brain Neoplasms / secondary. Brain Neoplasms / therapy. Female. Humans. Immunohistochemistry. Lung Neoplasms / diagnosis. Magnetic Resonance Imaging. Mammography. Melanoma / diagnosis. Middle Aged. Radiotherapy

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  • (PMID = 17590284.001).
  • [ISSN] 0368-2315
  • [Journal-full-title] Journal de gynécologie, obstétrique et biologie de la reproduction
  • [ISO-abbreviation] J Gynecol Obstet Biol Reprod (Paris)
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 17
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91. Sato KT, Lewandowski RJ, Mulcahy MF, Atassi B, Ryu RK, Gates VL, Nemcek AA Jr, Barakat O, Benson A 3rd, Mandal R, Talamonti M, Wong CY, Miller FH, Newman SB, Shaw JM, Thurston KG, Omary RA, Salem R: Unresectable chemorefractory liver metastases: radioembolization with 90Y microspheres--safety, efficacy, and survival. Radiology; 2008 May;247(2):507-15
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Primary sites (origins) included colon, breast, neuroendocrine, pancreas, lung, cholangiocarcinoma, melanoma, renal, esophageal, ovary, adenocarcinoma of unknown primary, lymphoma, gastric, duodenal, bladder, angiosarcoma, squamous cell carcinoma, thyroid, adrenal, and parotid.

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  • [Copyright] (c) RSNA, 2008.
  • (PMID = 18349311.001).
  • [ISSN] 1527-1315
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Databank-accession-numbers] ClinicalTrials.gov/ NCT00532740
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Yttrium Radioisotopes
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92. Kiluk JV, Yeh KA: Primary angiosarcoma of the breast. Breast J; 2005 Nov-Dec;11(6):517-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary angiosarcoma of the breast.
  • [MeSH-major] Breast Neoplasms / pathology. Hemangiosarcoma / pathology

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  • (PMID = 16297124.001).
  • [ISSN] 1075-122X
  • [Journal-full-title] The breast journal
  • [ISO-abbreviation] Breast J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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93. Bousquet G, Confavreux C, Magné N, de Lara CT, Poortmans P, Senkus E, de Lafontan B, Bolla M, Largillier R, Lagneau E, Kadish S, Lemanski C, Ozsahin M, Belkacémi Y: Outcome and prognostic factors in breast sarcoma: a multicenter study from the rare cancer network. Radiother Oncol; 2007 Dec;85(3):355-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Outcome and prognostic factors in breast sarcoma: a multicenter study from the rare cancer network.
  • BACKGROUND AND PURPOSE: Breast sarcoma (BS) is a rare tumour.
  • In multivariate analysis, favourable prognostic factors for better local control were: no residual tumour after treatment, no cellular pleomorphism, and histology other than angiosarcoma.
  • For DFS, the five favourable prognostic factors were non-menopausal status, no residual tumour after treatment, non-angiosarcoma histology, absence of tumour necrosis, and grade 1-2 histology.
  • CONCLUSION: While angiosarcoma has the worst prognosis, the outcome of the other types of sarcomas may be worsened by residual tumour after loco-regional treatment and high grade histology, a classical prognostic factor of the other soft tissue sarcomas.
  • [MeSH-major] Breast Neoplasms / therapy. Hemangiosarcoma / therapy

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  • (PMID = 18023492.001).
  • [ISSN] 0167-8140
  • [Journal-full-title] Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
  • [ISO-abbreviation] Radiother Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] Ireland
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94. Scow JS, Reynolds CA, Degnim AC, Petersen IA, Jakub JW, Boughey JC: Primary and secondary angiosarcoma of the breast: the Mayo Clinic experience. J Surg Oncol; 2010 Apr 1;101(5):401-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary and secondary angiosarcoma of the breast: the Mayo Clinic experience.
  • BACKGROUND AND OBJECTIVES: Angiosarcoma of the breast can be divided into primary and secondary.
  • The objective was to determine clinicopathologic factors associated with breast angiosarcoma and to compare primary versus secondary angiosarcoma.
  • METHODS: Breast angiosarcoma cases at Mayo Clinic from 1960 to 2008 were identified.
  • Characteristics of primary and secondary angiosarcoma were compared.
  • RESULTS: Twenty-seven cases of primary angiosarcoma and 14 cases of secondary angiosarcoma were identified.
  • The median age of primary angiosarcoma patients was lower than that of secondary angiosarcoma--43 years versus 73 years (P < 0.0001).
  • Primary angiosarcoma more frequently presented with a mass, whereas secondary angiosarcoma presented with a rash (P < 0.0001).
  • Median time from radiation to secondary angiosarcoma diagnosis was 6.8 years.
  • Median tumor size was 7.0 cm for primary angiosarcoma and 5.0 cm for secondary angiosarcoma (P = 0.7).
  • Tumors were high grade in 33% of primary angiosarcoma and 82% of secondary angiosarcoma (P = 0.02).
  • Five-year survival for primary and secondary angiosarcoma was 46% and 69%, respectively (P = 0.8).
  • CONCLUSION: Primary angiosarcoma occurs in younger patients than secondary and more frequently presents with a mass.
  • Mastectomy is the mainstay of treatment for breast angiosarcoma.
  • Breast angiosarcoma is a rare malignancy with poor long-term prognosis.
  • [MeSH-major] Breast Neoplasms / pathology. Hemangiosarcoma / pathology. Neoplasms, Second Primary / pathology

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  • [Copyright] (c) 2010 Wiley-Liss, Inc.
  • (PMID = 20119983.001).
  • [ISSN] 1096-9098
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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96. Catena F, Santini D, Di Saverio S, Laneve A, Ansaloni L, Fogacci T, Gagliardi S, Gazzotti F, Guidi G, De Cataldis A, Taffurelli M: Skin angiosarcoma arising in an irradiated breast: case-report and literature review. Dermatol Surg; 2006 Mar;32(3):447-55
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Skin angiosarcoma arising in an irradiated breast: case-report and literature review.
  • BACKGROUND: Angiosarcoma (AS) is a rare, invasive malignancy originating from endothelial cells caused by many different clinical situations.
  • AS following radiotherapy for breast cancer after conservative surgery is a rare but well-known association.
  • OBJECTIVE: The aim of this article is to describe a case of AS after breast conserving surgery and to review the literature to date.
  • She presented with a one-month history or red papular skin eruptions on the operated breast.
  • The patients was subjected to surgical excision of the remaining breast including all AS lesions.
  • CONCLUSION: Post-radiotherapy AS is rare neoplasm, but it should be considered in the case of patients with red lesions after breast conserving surgery and adjuvant radiotherapy.
  • [MeSH-major] Breast Neoplasms / radiotherapy. Carcinoma, Ductal, Breast / radiotherapy. Hemangiosarcoma / pathology. Skin Neoplasms / pathology

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  • (PMID = 16640696.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 74
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97. Ding HJ, Wei GG, Yu LQ, Wu QS, Dong YG: [Epithelioid angiosarcoma after radical mastectomy for breast carcinoma: a case report]. Zhonghua Bing Li Xue Za Zhi; 2006 Oct;35(10):637-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Epithelioid angiosarcoma after radical mastectomy for breast carcinoma: a case report].
  • [MeSH-major] Breast Neoplasms / pathology. Hemangiosarcoma / pathology. Neoplasms, Second Primary / pathology

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  • (PMID = 17134578.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Vimentin
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98. Altan E, Arslan C, Dede D, Dogan E, Altundag K: Primary angiosarcoma of the breast after pregnancy. Am Surg; 2010 Aug;76(8):E115
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary angiosarcoma of the breast after pregnancy.
  • [MeSH-major] Breast Neoplasms. Hemangiosarcoma
  • [MeSH-minor] Adult. Biopsy. Diagnosis, Differential. Female. Humans. Mastectomy. Ultrasonography, Mammary

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  • (PMID = 21513627.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] Angiosarcoma of the breast
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99. Bernier J: Potential risks and benefits of radiation therapy as adjuvant treatment in patients with low-risk carcinoma of the mammary gland: taking cutaneous postradiation angiosarcoma as an opportunity for a critical appraisal of postoperative radiotherapy. Ann Oncol; 2007 Apr;18(4):619-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Potential risks and benefits of radiation therapy as adjuvant treatment in patients with low-risk carcinoma of the mammary gland: taking cutaneous postradiation angiosarcoma as an opportunity for a critical appraisal of postoperative radiotherapy.

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  • [CommentOn] Ann Oncol. 2007 Apr;18(4):801 [17229767.001]
  • (PMID = 17351257.001).
  • [ISSN] 0923-7534
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Comment; Editorial
  • [Publication-country] England
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100. Lucas DR: Angiosarcoma, radiation-associated angiosarcoma, and atypical vascular lesion. Arch Pathol Lab Med; 2009 Nov;133(11):1804-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma, radiation-associated angiosarcoma, and atypical vascular lesion.
  • Angiosarcoma, one of the least common sarcomas, has become increasingly important because of its association with radiation therapy, especially for breast cancer.
  • However, angiosarcoma has a wide anatomic distribution including soft tissue, visceral organ, and osseous locations.
  • Radiation-associated angiosarcoma typically presents as a cutaneous tumor several years posttherapy.
  • The latency for radiation-associated mammary angiosarcoma is relatively short, sometimes less than 3 years.
  • Although most atypical vascular lesions pursue a benign course, they recur and very rarely progress to angiosarcoma.
  • Distinguishing this lesion from well-differentiated angiosarcoma in a biopsy can be challenging, especially because areas indistinguishable from atypical vascular lesion are found adjacent to angiosarcoma.
  • [MeSH-major] Hemangioma / pathology. Hemangiosarcoma / pathology. Neoplasms, Radiation-Induced / pathology. Skin Neoplasms / pathology. Vascular Diseases / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Breast Neoplasms / radiotherapy. Female. Humans. Skin / blood supply

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  • (PMID = 19886715.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 12
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