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Items 1 to 100 of about 169
1. Kar A, Mukhopadhyay D, Das SS, Swain NN, Das BM, Nayak M, Rath J, Satpathy S: Cytodiagnosis of angiosarcoma of breast. Indian J Pathol Microbiol; 2008 Jul-Sep;51(3):427-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytodiagnosis of angiosarcoma of breast.
  • A 24-year-old female presented with swelling in the left breast for one-and-a-half years associated with pain for last 4 months.
  • The case was diagnosed by preoperative cytology as angiosarcoma of breast, after which, she underwent modified radical mastectomy.
  • Angiosarcoma of breast is uncommon with extremely bad prognosis.
  • [MeSH-major] Breast Neoplasms / diagnosis. Hemangiosarcoma / diagnosis

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  • (PMID = 18723981.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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2. Kim SW, Wylie J: Spontaneous regression of pulmonary metastases from breast angiosarcoma. Sarcoma; 2008;2008:940656

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spontaneous regression of pulmonary metastases from breast angiosarcoma.
  • We present a rare case of pulmonary metastases in a 72-year-old woman with metastatic breast angiosarcoma.
  • She was diagnosed with a breast angiosarcoma in 2005 and underwent a total mastectomy and postoperative radiotherapy.
  • Seven months after the diagnosis of metastatic disease, the nodules in her scalp remain controlled.

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  • (PMID = 19081840.001).
  • [ISSN] 1357-714X
  • [Journal-full-title] Sarcoma
  • [ISO-abbreviation] Sarcoma
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC2593410
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3. Vorburger SA, Xing Y, Hunt KK, Lakin GE, Benjamin RS, Feig BW, Pisters PW, Ballo MT, Chen L, Trent J 3rd, Burgess M, Patel S, Pollock RE, Cormier JN: Angiosarcoma of the breast. Cancer; 2005 Dec 15;104(12):2682-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma of the breast.
  • BACKGROUND: Angiosarcoma of the breast is a rare entity.
  • METHODS: Clinical and pathologic factors were analyzed in all patients with angiosarcoma of the breast treated between 1990 and 2003.
  • RESULTS: Fifty-five women with angiosarcoma of the breast were identified.
  • For the 32 patients with primary angiosarcoma of the breast 5-year OS was 59%.
  • Twenty-three (42%) patients had received prior radiation therapy for the treatment of breast cancer.
  • These patients with radiation therapy-associated angiosarcoma were on average 30 years older and less likely to present with distant metastatic disease than patients presenting with radiation-naive angiosarcoma of the breast.
  • CONCLUSIONS: In this series of 55 patients with angiosarcoma of the breast, radiation therapy-naive angiosarcomas occurred in younger patients, but they behaved similarly to radiation therapy-associated angiosarcomas.
  • [MeSH-major] Breast Neoplasms / mortality. Breast Neoplasms / therapy. Hemangiosarcoma / mortality. Hemangiosarcoma / therapy. Mastectomy / methods

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  • [Copyright] Copyright 2005 American Cancer Society.
  • (PMID = 16288486.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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4. Altan E, Arslan C, Dede D, Dogan E, Altundag K: Primary Angiosarcoma of the Breast after Pregnancy. Am Surg; 2010 Aug 01;76(8):115

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary Angiosarcoma of the Breast after Pregnancy.

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  • (PMID = 28958226.001).
  • [ISSN] 1555-9823
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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5. Losanoff JE, Jaber S, Esuba M, Perry M, Sauter ER: Primary angiosarcoma of the breast: do enlarged axillary nodes matter? Breast J; 2006 Jul-Aug;12(4):371-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary angiosarcoma of the breast: do enlarged axillary nodes matter?
  • Primary angiosarcoma of the breast is a rare and aggressive malignancy that is typically seen in premenopausal patients.
  • We present a case of breast angiosarcoma presenting with enlarged axillary lymph nodes treated with a modified mastectomy and axillary lymph node dissection.
  • [MeSH-major] Breast Neoplasms / pathology. Hemangiosarcoma / pathology. Lymph Nodes / pathology

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  • (PMID = 16848851.001).
  • [ISSN] 1075-122X
  • [Journal-full-title] The breast journal
  • [ISO-abbreviation] Breast J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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6. Liu H, Zhao J, Fan Y, Fu XL, Fu L: [Clinical and pathologic characteristics of primary angiosarcoma of breast]. Zhonghua Bing Li Xue Za Zhi; 2006 Oct;35(10):598-601
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinical and pathologic characteristics of primary angiosarcoma of breast].
  • OBJECTIVE: To study the clinical and pathologic characteristics of primary angiosarcoma of breast.
  • METHODS: Five cases of primary angiosarcoma of breast were reviewed.
  • RESULTS: All of the 5 patients had a history of a painless breast lump.
  • CONCLUSIONS: Primary angiosarcoma of breast is a rare entity.
  • The diagnosis is rather difficult owing to the lack of specific clinical findings and histological heterogeneity.
  • Application of Positive expression of endothelial associated antigens of the tumors cells is helpful in making a pathological diagnosis morphologically.
  • [MeSH-major] Breast Neoplasms / pathology. Breast Neoplasms, Male / pathology. Hemangiosarcoma / pathology
  • [MeSH-minor] Adult. Antigens, CD31 / metabolism. Antigens, CD34 / metabolism. Breast / metabolism. Breast / pathology. Breast / surgery. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Immunohistochemistry. Male. Mastectomy / methods. Middle Aged. von Willebrand Factor / metabolism

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  • (PMID = 17134567.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Antigens, CD34; 0 / von Willebrand Factor
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7. Rohan VS, Hanji AM, Patel JJ, Tankshali RA: Primary angiosarcoma of the breast in a postmenopausal patient. J Cancer Res Ther; 2010 Jan-Mar;6(1):120-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary angiosarcoma of the breast in a postmenopausal patient.
  • Primary angiosarcoma of the breast is a rare entity forming 0.04% of primary breast tumors.
  • [MeSH-major] Breast Neoplasms / pathology. Hemangiosarcoma / pathology

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  • (PMID = 20479566.001).
  • [ISSN] 1998-4138
  • [Journal-full-title] Journal of cancer research and therapeutics
  • [ISO-abbreviation] J Cancer Res Ther
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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8. van Geel AN, den Bakker MA: Bilateral angiosarcoma of the breast in a fourteen-year-old child. Rare Tumors; 2009;1(2):e38

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bilateral angiosarcoma of the breast in a fourteen-year-old child.
  • Malignant vascular tumors are rare and angiosarcomas of the breast in patients under 21 years of age are exceedingly uncommon.
  • In this report an angiosarcoma in the breast of a 14-year-old girl is described.
  • She died nine months after mastectomy with recurrent disease in the bones and the contralateral breast.
  • The histology of this angiosarcoma is illustrated.

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  • (PMID = 21139917.001).
  • [ISSN] 2036-3613
  • [Journal-full-title] Rare tumors
  • [ISO-abbreviation] Rare Tumors
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2994455
  • [Keywords] NOTNLM ; angiosarcoma / breast. / infancy
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9. Moore A, Hendon A, Hester M, Samayoa L: Secondary angiosarcoma of the breast: can imaging findings aid in the diagnosis? Breast J; 2008 May-Jun;14(3):293-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Secondary angiosarcoma of the breast: can imaging findings aid in the diagnosis?
  • Secondary angiosarcomas, although rare, are aggressive tumors that can develop in breast tissue that has undergone prior radiation therapy.
  • We present three cases of secondary angiosarcoma of the breast in the setting of prior breast irradiation.
  • Imaging findings include cutaneous nodules and progressive skin or trabecular thickening in an area of the breast separate from the patient's original breast carcinoma.
  • These imaging findings may enable the radiologist to suggest this diagnosis, even when the clinical presentation is more benign.
  • [MeSH-major] Breast Neoplasms / diagnosis. Hemangiosarcoma / diagnosis. Neoplasm Recurrence, Local / diagnosis. Neoplasms, Radiation-Induced / diagnosis

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  • (PMID = 18476885.001).
  • [ISSN] 1524-4741
  • [Journal-full-title] The breast journal
  • [ISO-abbreviation] Breast J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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10. Leung F, Terzibachian JJ, Gay C, Bourtembourg A, Sautière JL, Maillet R, Riethmuller D: [Radiation-induced breast angiosarcoma following breast-conserving therapy. Report of two cases]. Gynecol Obstet Fertil; 2010 Mar;38(3):214-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Radiation-induced breast angiosarcoma following breast-conserving therapy. Report of two cases].
  • [Transliterated title] Angiosarcome mammaire radio-induit après traitement conservateur du cancer du sein. A propos de deux cas.
  • Breast angiosarcoma is a rare but serious complication of radiotherapy.
  • We report two cases of radiation-induced breast angiosarcoma in two patients having benefited from breast conserving surgery with radiation.
  • [MeSH-major] Breast Neoplasms / etiology. Hemangiosarcoma / etiology. Neoplasms, Radiation-Induced

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  • [Copyright] Copyright 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20153679.001).
  • [ISSN] 1769-6682
  • [Journal-full-title] Gynécologie, obstétrique & fertilité
  • [ISO-abbreviation] Gynecol Obstet Fertil
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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11. Patnaik A, Chiorean EG, Tolcher A, Papadopoulos K, Beeram M, Kee D, Waddell M, Gilles E, Buchbinder A: EZN-2968, a novel hypoxia-inducible factor-1α (HIF-1α) messenger ribonucleic acid (mRNA) antagonist: Results of a phase I, pharmacokinetic (PK), dose-escalation study of daily administration in patients (pts) with advanced malignancies. J Clin Oncol; 2009 May 20;27(15_suppl):2564

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Tumor types included colorectal cancer (7 pts); renal cancer (4 pts); soft-tissue sarcoma (STS; 2 pts); angiosarcoma (1 pt); melanoma (1 pt); and breast, ovarian, pancreatic, and prostate cancers (1 pt each).
  • Stable disease was observed for 1 pt with angiosarcoma (28 wks) and 1 pt with renal cancer (12 wks).

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  • (PMID = 27961885.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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12. Pink D, Rahm J, Schoeler D, Schoenknecht TM, Reichardt P: Activity of paclitaxel in radiation induced and other secondary angiosarcomas. J Clin Oncol; 2009 May 20;27(15_suppl):10578

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • 12 female patients suffered from angiosarcoma of the breast/thoracic wall following operation and radiation + chemotherapy of a primary breast cancer with an interval of a median of 6 years (range 2-15 years).

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  • (PMID = 27963758.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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13. Galaychuk I: Breast sarcomas: Is now the time to change our mind? J Clin Oncol; 2009 May 20;27(15_suppl):e21524

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Breast sarcomas: Is now the time to change our mind?
  • : e21524 Background: Primary breast sarcoma usually was considered a rare malignant disease [Adem et al., 2004].
  • The aim of this study is to show the incidence of breast sarcoma in the region with female population of about 600,000.
  • METHODS: Retrospective comparative analysis of breast sarcoma and breast cancer incidence in female of Ternopil region for 2000 - 2008.
  • RESULTS: The total of 101 cases of breast sarcoma was diagnosed in female of 39 - 76 years of age.
  • Every year about 11 (6-18) primary breast sarcomas and 256 (233-279) patients with primary breast cancer were detected.
  • The incidence rate of breast sarcoma was 1.14 per 100,000 women in 2000, 2.94 (in 2001), 1.48 (2002), 0.99 (2003), 2.16 (2004), 1.67 (2005), 2.53 (2006), 2.03 (2007) and 1.87/100,000 in 2008.
  • The incidence of breast cancer was ranged from 37.3 to 46.4 per 100,000 of female population.
  • Breast sarcoma consisted of 2.5% of the breast malignancies in 2000, 6.5% (in 2001), 3.3% (2002), 2.6% (2003), 5.4% (2004), 4.1% (2005), 5.9% (2006), 4.4% (2007) and 4.7% in 2008.
  • Pathohistologic examination revealed angiosarcoma in 92.1% of cases.
  • Thus, our findings are significantly different than data of other authors: f.e., the incidence of primary breast sarcoma is at 45 new cases per 10 million women [Confavreux et al., 2003], or 17 new cases per million women [Moore and Kinne, 1996], and breast sarcoma accounting for 0.0006% of breast malignancies which were diagnosed in 1910-2000 [Adem, 2004].
  • Taking into account all historical and recent data we can suggest beginning of biological changing in correlation between breast malignant tumors-carcinoma and sarcoma.
  • CONCLUSIONS: Our statistical finding shows that incidence of breast sarcoma is 1.87 (0.99-2.94) per of 100,000 female population, and now sarcomas consist of 4.4% (2.5-6.5%) of all malignant breast tumors.
  • Angiosarcoma is a most common (92.1%) morphological type of breast sarcomas.

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  • (PMID = 27963454.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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14. Ramon Y Cajal T, Mazarico J, Lopez Pousa A, Quintana M, Sala N, Altabas M, Sebio A, Robert L, Alonso C, Barnadas A: Clinical features and outcome in primary breast sarcomas (BS): Analysis of a single-institution experience. J Clin Oncol; 2009 May 20;27(15_suppl):e21520

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical features and outcome in primary breast sarcomas (BS): Analysis of a single-institution experience.
  • Pathology: 17 cistosarcoma phylodes (CPh), 9 angiosarcoma, 2 extraesqueletical osteosarcoma, 2 fibrosarcomas, 1 liposarcoma, 1 leiomiosarcoma, 1 malignant fibrous histiocitoma (2.9%).

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  • (PMID = 27963450.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. Vertse G, Svastics E, Iványi A: [Postirradiation angiosarcoma of the breast]. Magy Seb; 2010 Aug;63(4):164-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Postirradiation angiosarcoma of the breast].
  • [Transliterated title] Besugárzás utáni angiosarcoma emloben.
  • Although secondary angiosarcomas (AS) are relatively rare neoplasms, they are increasingly recognized as the result of more breast conserving therapy (BCT) followed by radiotherapy.
  • The diagnosis of this very aggressive and rapidly spreading tumour is based on the immunohystochemical characteristics of the biopsy specimen.
  • 10 years later secondary AS occurred in the remaining breast.
  • [MeSH-major] Breast Neoplasms / radiotherapy. Hemangiosarcoma / diagnosis. Hemangiosarcoma / etiology. Mastectomy, Segmental. Neoplasms, Second Primary / diagnosis. Neoplasms, Second Primary / etiology

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  • (PMID = 20724241.001).
  • [ISSN] 0025-0295
  • [Journal-full-title] Magyar sebészet
  • [ISO-abbreviation] Magy Seb
  • [Language] hun
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Hungary
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers, Tumor
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16. Champeaux-Orange E, Bonneau C, Raharimanana B, Favre A, Ibrahim M, Breteau N: [Primary breast angiosarcoma: two case reports]. Cancer Radiother; 2009 Jun;13(3):209-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Primary breast angiosarcoma: two case reports].
  • [Transliterated title] Angiosarcome mammaire primitif: à propos de deux cas.
  • Primary angiosarcoma is a rare type of breast cancer, the diagnosis is difficult to establish and it has the worst prognostic of all breast malignancies.
  • Two cases of primary breast angiosarcoma have been observed at the centre Henry Kaplan of Tours and at the hospital La Source of Orleans since 2001.
  • [MeSH-major] Breast Neoplasms / pathology. Hemangiosarcoma / pathology

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  • (PMID = 19410492.001).
  • [ISSN] 1278-3218
  • [Journal-full-title] Cancer radiothérapie : journal de la Société française de radiothérapie oncologique
  • [ISO-abbreviation] Cancer Radiother
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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17. Pai MR, Upadhyaya K, Naik R, Malhotra S: Bilateral angiosarcoma breast diagnosed by fine needle aspiration cytology. Indian J Pathol Microbiol; 2008 Jul-Sep;51(3):421-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bilateral angiosarcoma breast diagnosed by fine needle aspiration cytology.
  • Concurrent or synchronous angiosarcoma (AS) of breast is a rarity.
  • Specific recognition of this neoplasm in cytological specimens is difficult and conclusive diagnosis in the absence of ancillary methods is achieved only uncommonly.
  • This case report emphasizes that when aspiration smears show vasoformative features consisting of microacini, arborizing microtissue fragments and intracytoplasmic lumen against a bloody background, diagnosis can be made conclusively by FNA with immunohistochemical confirmation.
  • [MeSH-major] Breast Neoplasms / diagnosis. Hemangiosarcoma / diagnosis

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  • (PMID = 18723979.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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18. Gennaro M, Valeri B, Casalini P, Carcangiu ML, Gronchi A, Conti AR, Agresti R, Greco M: Angiosarcoma of the breast and vascular endothelial growth factor receptor. Tumori; 2010 Nov-Dec;96(6):930-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma of the breast and vascular endothelial growth factor receptor.
  • BACKGROUND: Breast angiosarcoma is rare and often associated with previous breast cancer treatment.
  • PATIENTS AND METHODS: We retrospectively assessed outcomes in relation to age, association with previous breast-conserving treatment for breast cancer, tumor size, and grade in 19 patients without metastases at diagnosis.
  • [MeSH-major] Angiogenesis Inhibitors / therapeutic use. Breast Neoplasms / metabolism. Neoplasms, Second Primary / metabolism. Receptors, Vascular Endothelial Growth Factor / drug effects. Receptors, Vascular Endothelial Growth Factor / metabolism
  • [MeSH-minor] Disease-Free Survival. Female. Gene Expression Regulation, Neoplastic. Hemangiosarcoma / drug therapy. Hemangiosarcoma / etiology. Hemangiosarcoma / metabolism. Hemangiosarcoma / pathology. Hemangiosarcoma / therapy. Humans. Male. Mastectomy, Segmental. Middle Aged. Radiotherapy, Adjuvant / adverse effects. Retrospective Studies. Treatment Outcome

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  • (PMID = 21388054.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; EC 2.7.10.1 / Receptors, Vascular Endothelial Growth Factor; Angiosarcoma of the breast
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19. Scow JS, Reynolds CA, Degnim AC, Petersen IA, Jakub JW, Boughey JC: Primary and secondary angiosarcoma of the breast: the Mayo Clinic experience. J Surg Oncol; 2010 Apr 1;101(5):401-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary and secondary angiosarcoma of the breast: the Mayo Clinic experience.
  • BACKGROUND AND OBJECTIVES: Angiosarcoma of the breast can be divided into primary and secondary.
  • The objective was to determine clinicopathologic factors associated with breast angiosarcoma and to compare primary versus secondary angiosarcoma.
  • METHODS: Breast angiosarcoma cases at Mayo Clinic from 1960 to 2008 were identified.
  • Characteristics of primary and secondary angiosarcoma were compared.
  • RESULTS: Twenty-seven cases of primary angiosarcoma and 14 cases of secondary angiosarcoma were identified.
  • The median age of primary angiosarcoma patients was lower than that of secondary angiosarcoma--43 years versus 73 years (P < 0.0001).
  • Primary angiosarcoma more frequently presented with a mass, whereas secondary angiosarcoma presented with a rash (P < 0.0001).
  • Median time from radiation to secondary angiosarcoma diagnosis was 6.8 years.
  • Median tumor size was 7.0 cm for primary angiosarcoma and 5.0 cm for secondary angiosarcoma (P = 0.7).
  • Tumors were high grade in 33% of primary angiosarcoma and 82% of secondary angiosarcoma (P = 0.02).
  • Five-year survival for primary and secondary angiosarcoma was 46% and 69%, respectively (P = 0.8).
  • CONCLUSION: Primary angiosarcoma occurs in younger patients than secondary and more frequently presents with a mass.
  • Mastectomy is the mainstay of treatment for breast angiosarcoma.
  • Breast angiosarcoma is a rare malignancy with poor long-term prognosis.
  • [MeSH-major] Breast Neoplasms / pathology. Hemangiosarcoma / pathology. Neoplasms, Second Primary / pathology

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  • [Copyright] (c) 2010 Wiley-Liss, Inc.
  • (PMID = 20119983.001).
  • [ISSN] 1096-9098
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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20. Bernathova M, Jaschke W, Pechlahner C, Zelger B, Bodner G: Primary angiosarcoma of the breast associated Kasabach-Merritt syndrome during pregnancy. Breast; 2006 Apr;15(2):255-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary angiosarcoma of the breast associated Kasabach-Merritt syndrome during pregnancy.
  • Primary angiosarcoma of the breast is a rare aggressive tumour of unknown etiology.
  • A frequent clinical presentation is a painful palpable smooth mass or diffuse enlargement of the breast without a palpable mass but with purple discolouration of the overlying skin with apparent bruising.
  • An uncommon clinical presentation of an angiosarcoma is spontaneous bleeding due to disseminated intravascular coagulation (DIC) by consumption coagulopathy, known as the Kasabach-Merritt syndrome.
  • Imaging characteristics of a breast angiosarcoma are limited to a few radiological reports.
  • We report a case of a young pregnant woman with a bleeding angiosarcoma of the breast and associated Kasabach-Merritt syndrome and describe the sonographic and MRI findings.
  • [MeSH-major] Breast Neoplasms / diagnosis. Disseminated Intravascular Coagulation / diagnosis. Hemangiosarcoma / diagnosis. Pregnancy Complications, Hematologic / diagnosis. Pregnancy Complications, Neoplastic / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Pregnancy. Pregnancy Trimester, Second. Prenatal Diagnosis. Syndrome

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  • (PMID = 16000250.001).
  • [ISSN] 0960-9776
  • [Journal-full-title] Breast (Edinburgh, Scotland)
  • [ISO-abbreviation] Breast
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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21. Gatcombe HG, Olson TA, Esiashvili N: Metastatic primary angiosarcoma of the breast in a pediatric patient with a complete response to systemic chemotherapy and definitive radiation therapy: case report and review of the literature. J Pediatr Hematol Oncol; 2010 Apr;32(3):192-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic primary angiosarcoma of the breast in a pediatric patient with a complete response to systemic chemotherapy and definitive radiation therapy: case report and review of the literature.
  • We present a case of a rare malignancy, primary breast angiosarcoma, in a 15-year-old girl.
  • The patient was treated with systemic chemotherapy and definitive radiation therapy to her left breast and achieved a complete response.
  • She has no evidence of disease recurrence 44 months from her initial diagnosis.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bone Neoplasms / therapy. Breast Neoplasms / therapy. Hemangiosarcoma / therapy. Mediastinal Neoplasms / therapy. Radiotherapy

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  • (PMID = 20186104.001).
  • [ISSN] 1536-3678
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; UM20QQM95Y / Ifosfamide
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22. Kardum-Skelin I, Jelić-Puskarić B, Pazur M, Vidić-Paulisić I, Jakić-Razumović J, Separović V: A case report of breast angiosarcoma. Coll Antropol; 2010 Jun;34(2):645-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case report of breast angiosarcoma.
  • Angiosarcoma is a rare disease of the breast with the reported incidence of only 0.04% of all breast malignancies.
  • The etiology of angiosarcoma remains unknown.
  • We present a patient with angiosarcoma which developed 12 years of the diagnosis of breast carcinoma and 8 years of the operative procedure and radiotherapy for disease recurrence.
  • A small angiomatous lesion of a few mm in size, cytologically suspect of vascular tumor (hemangioma or hemangiopericytoma) and histopathologically verified to be an atypical vascular lesion, was detected two years before breast enlargement and cytologic and histologic diagnosis of angiosarcoma.
  • The patient died 15 months of the diagnosis of angiosarcoma, after two tumor recurrences and intrathoracic cavity invasion.
  • [MeSH-major] Breast Neoplasms / pathology. Hemangiosarcoma / pathology

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  • (PMID = 20698145.001).
  • [ISSN] 0350-6134
  • [Journal-full-title] Collegium antropologicum
  • [ISO-abbreviation] Coll Antropol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
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23. Souza FF, Katkar A, den Abbeele AD, Dipiro PJ: Breast angiosarcoma metastatic to the ovary. Case Rep Med; 2009;2009:381015
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Breast angiosarcoma metastatic to the ovary.
  • Primary angiosarcoma can arise anywhere in the body and when it arises in the breast, it usually affects women in their 3rd and 4th decades and accounts for one in 1700-2300 cases of primary breast cancer.
  • Although unusual, breast angiosarcomas tend to metastasize hematogenously rather than lymphogenously, have high rates of local recurrence, that often develop metastases soon after treatment, and have a dismal prognosis.
  • We present a case of a solitary ovarian metastasis from angiosarcoma of the breast.

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  • [Cites] J Surg Oncol. 2006 Oct 1;94(5):368-74 [16967461.001]
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  • (PMID = 19718246.001).
  • [ISSN] 1687-9627
  • [Journal-full-title] Case reports in medicine
  • [ISO-abbreviation] Case Rep Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2729273
  •  go-up   go-down


24. Fernández Ortega A, Gil Gil JM, Urruticoetxea A, Serra Payró JM: Angiosarcoma of the breast. Two cases following breast conserving treatment for invasive carcinoma. Clin Transl Oncol; 2006 Jul;8(7):536-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma of the breast. Two cases following breast conserving treatment for invasive carcinoma.
  • Angiosarcoma of the breast is a rare malignant tumour.
  • It can be primary or secondary in women who have been treated of a ductal carcinoma of the breast.
  • [MeSH-major] Brachytherapy. Breast Neoplasms / etiology. Carcinoma, Ductal, Breast / radiotherapy. Carcinoma, Ductal, Breast / surgery. Hemangiosarcoma / etiology. Mastectomy, Segmental. Neoplasms, Second Primary / etiology

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  • (PMID = 16870544.001).
  • [ISSN] 1699-048X
  • [Journal-full-title] Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
  • [ISO-abbreviation] Clin Transl Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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25. Fujita T, Taira N, Ogasawara Y, Omori M, Doihara H: Bilateral angiosarcoma of the breast detected by magnetic resonance imaging during pregnancy. Int J Clin Oncol; 2009 Dec;14(6):560-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bilateral angiosarcoma of the breast detected by magnetic resonance imaging during pregnancy.
  • Angiosarcoma of the breast is an aggressive malignancy of endothelial origin with a tendency for local regional recurrence.
  • Of note, due to its rarity and typically unclear clinical findings upon examination, the diagnosis of a contralateral lesion can be difficult, particularly in women during pregnancy.
  • Here we present a rare case of bilateral angiosarcoma of the breast during pregnancy.
  • A 32-year-old woman was referred to our unit with complaints of progressive swelling of the left breast, with tenderness.
  • Magnetic resonance imaging showed a small, circumscribed high-intensity area in the contralateral breast, with pattern similar to that of the lesion found in the left breast.
  • Diagnosed as angiosarcoma preoperatively, excision of the bilateral tumors was performed.
  • Histological findings of the removed bilateral tumors were compatible with high-grade angiosarcoma of the breast.
  • [MeSH-major] Breast Neoplasms / diagnosis. Hemangiosarcoma / diagnosis. Magnetic Resonance Imaging. Mammary Glands, Human / pathology. Pregnancy Complications, Neoplastic / diagnosis

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  • (PMID = 19967497.001).
  • [ISSN] 1437-7772
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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26. Biswas T, Tang P, Muhs A, Ling M: Angiosarcoma of the breast: a rare clinicopathological entity. Am J Clin Oncol; 2009 Dec;32(6):582-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma of the breast: a rare clinicopathological entity.
  • OBJECTIVES: Angiosarcoma is a rare subtype of sarcoma that usually arises after radiation therapy for primary breast cancer.
  • Primary sarcomas of the breast are rare entities and account for less than 1% of all malignant breast neoplasms.
  • We examine our institutional experience with angiosarcomas of the breast that were diagnosed and treated between 1996 and 2007.
  • METHODS: To conduct a retrospective review, all female patients with a diagnosis of angiosarcoma of the breast were identified from our pathology database.
  • RESULTS: A total of 8 patients were identified who had a histologically confirmed diagnosis of angiosarcoma of the breast.
  • Median age was 70.3 years at diagnosis (range, 35.6-85.7 years).
  • Seven (87%) patients had a history of prior radiation to the breast, whereas 1 (13%) had primary angiosarcoma.
  • CONCLUSIONS: Even though angiosarcomas are rare neoplasms, they are increasingly recognized as the result of more breast-conserving therapy.
  • High clinical suspicion and MRI may contribute to early diagnosis but a biopsy is always necessary to confirm it.
  • [MeSH-major] Breast Neoplasms / pathology. Hemangiosarcoma / pathology. Neoplasms, Radiation-Induced / pathology. Neoplasms, Second Primary / pathology

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  • (PMID = 19581792.001).
  • [ISSN] 1537-453X
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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27. Granier G, Lemoine MC, Mares P, Pignodel C, Marty-Double C: [Primary angiosarcoma of the male breast]. Ann Pathol; 2005 Jun;25(3):235-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Primary angiosarcoma of the male breast].
  • [Transliterated title] Angiosarcome primitif du sein chez l'homme.
  • We report an exceptional case of primary breast angiosarcoma in a 58-year-old man.
  • This is a very rare breast tumor (0.04% of breast tumors) which may be difficult to diagnose.
  • Diagnosis should be established as early as possible because the 10-year overall survival rate is 80% for low grade tumors and only 20% for high grade tumors.
  • [MeSH-major] Breast Neoplasms / pathology. Hemangiosarcoma / pathology

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  • (PMID = 16230950.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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28. Rozen WM, Mann GB: Angiosarcoma arising in an unirradiated breast with subsequent pituitary metastasis. Clin Breast Cancer; 2007 Oct;7(10):811-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma arising in an unirradiated breast with subsequent pituitary metastasis.
  • Angiosarcoma of the breast is a rare condition with known risk factors.
  • The Stewart-Treves syndrome describes angiosarcoma of the arm or breast in the setting of adjuvant radiation therapy (RT) after breast conservation surgery.
  • Angiosarcoma of the breast, in the absence of RT, is rarer still.
  • We present a unique case of angiosarcoma of the breast, diagnosed 6 years after conservative surgery for carcinoma of the breast when no adjuvant RT was given.
  • Chronic postoperative lymphoedema in the breast delayed the investigation of skin changes, with an eventual diagnosis of angiosarcoma.
  • An isolated pituitary metastasis 9 months from the diagnosis, the first such reported case, adds to the complexity of the case.
  • The diagnosis and management of angiosarcoma of the breast is discussed.
  • Angiosarcoma is a rare occurrence after breast conservative surgery.
  • Postoperative lymphoedema can impede early diagnosis.
  • [MeSH-major] Breast Neoplasms / pathology. Hemangiosarcoma / secondary. Neoplasms, Second Primary / pathology. Pituitary Neoplasms / secondary
  • [MeSH-minor] Carcinoma, Ductal, Breast / pathology. Carcinoma, Ductal, Breast / surgery. Female. Humans. Middle Aged. Neoplasms, Radiation-Induced / pathology

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  • (PMID = 18021485.001).
  • [ISSN] 1526-8209
  • [Journal-full-title] Clinical breast cancer
  • [ISO-abbreviation] Clin. Breast Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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29. Takenaka M, Tanaka M, Isobe M, Yamaguchi R, Kojiro M, Shirouzu K: Angiosarcoma of the breast with silicone granuloma: a case report. Kurume Med J; 2009;56(1-2):33-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma of the breast with silicone granuloma: a case report.
  • Angiosarcoma of the breast is a rare non-epithelial tumor and that accounts for less than 0.1% of primary malignancies of the breast.
  • The disease has a relatively higher occurrence among young people, and its prognosis (3-year-survival of only 38%) is extremely poor compared to breast cancer.
  • Here we present a case of an 87-year-old woman who had undergone bilateral breast augmentation with silicone injections in her youth.
  • Although she became aware of a tumor in her right breast, she waited 8 years before seeking treatment.
  • Two years later she was brought to our hospital by ambulance for continuous bleeding from the same tumor of the breast, which by that time was over 11 cm in diameter.
  • The histological diagnosis was angiosarcoma of the breast with silicone granuloma.
  • [MeSH-major] Breast Implantation / adverse effects. Breast Neoplasms / etiology. Hemangiosarcoma / etiology. Silicone Gels / adverse effects

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  • (PMID = 20103999.001).
  • [ISSN] 1881-2090
  • [Journal-full-title] The Kurume medical journal
  • [ISO-abbreviation] Kurume Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Silicone Gels
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30. Kinderyte R, Alisauskaite L, Juodzbaliene EB, Juozaityte E: [Angiosarcoma of the breast: a case report and literature review]. Medicina (Kaunas); 2006;42(7):580-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Angiosarcoma of the breast: a case report and literature review].
  • Sarcoma of the breast is a rare tumor (makes up 0.5 to 1% of all malignant breast tumors).
  • In literature, only isolated cases of primary angiosarcoma of the breast were described.
  • Secondary angiosarcomas are more frequently diagnosed in women and mostly in patients who underwent breast-conserving surgery and were treated by radiotherapy.
  • In this article a very rare case of angiosarcoma of the breast is presented.
  • The tumor in the breast was diagnosed after breast trauma.
  • After surgery the diagnosis of hematoma was made.
  • After review of histopathology slides the likely diagnosis of angiosarcoma of the breast was made.
  • A patient from the time of diagnosis survived for 8 months.
  • The mean survival of patients with angiosarcoma of the breast, described in literature, ranges from 13 to 22 months, and the treatment in this case most likely could not have an effect on survival of the patient.
  • [MeSH-major] Breast Neoplasms. Hemangiosarcoma
  • [MeSH-minor] Adult. Breast / pathology. Diagnosis, Differential. Female. Humans. Lung Neoplasms / radiography. Lung Neoplasms / secondary. Lymphatic Metastasis / diagnosis. Mastectomy, Simple. Prognosis. Radiography, Thoracic. Time Factors

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  • (PMID = 16861841.001).
  • [ISSN] 1648-9144
  • [Journal-full-title] Medicina (Kaunas, Lithuania)
  • [ISO-abbreviation] Medicina (Kaunas)
  • [Language] lit
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Lithuania
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31. Wang XY, Jakowski J, Tawfik OW, Thomas PA, Fan F: Angiosarcoma of the breast: a clinicopathologic analysis of cases from the last 10 years. Ann Diagn Pathol; 2009 Jun;13(3):147-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma of the breast: a clinicopathologic analysis of cases from the last 10 years.
  • Breast angiosarcoma may occur de novo, or as a complication of radiation therapy, or chronic lymphedema secondary to axillary lymph node dissection for mammary carcinoma.
  • In our effort to characterize the clinicopathologic features of breast angiosarcoma, we reviewed all breast angiosarcoma cases in the University of Kansas Medical Center and Ohio State University Medical Center archives from 1997 to 2007.
  • Only 11 angiosarcomas were identified among more than 5000 malignant breast neoplasms (0.1%-0.2% incidence) for the last 10 years.
  • Eight cases (6 high grade, 1 intermediate grade, 1 low grade) were identified as postradiation angiosarcoma (postradiation time interval, 4-12 years), and 3 cases were identified as primary angiosarcomas (1 high grade, 2 low grade).
  • Follow-up (median, 36 months) revealed that 3 cases of postradiation angiosarcoma recurred as skin and/or chest wall lesions and 1 case of primary angiosarcoma developed liver metastases (all high-grade).
  • In conclusion, breast angiosarcoma remains a rare disease.
  • Rosen's method for grading breast angiosarcoma is easy to implement and correlates well with clinical outcome.
  • There are no distinct clinical or histologic differences between primary and postradiation breast angiosarcomas.
  • [MeSH-major] Breast Neoplasms / pathology. Hemangiosarcoma / pathology

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  • (PMID = 19433291.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 12
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32. Tomasello L, Gardin G, Boccardo F: Secondary breast angiosarcoma: lethal response to anti-angiogenic therapy with paclitaxel chemotherapy. A case report. Anticancer Res; 2006 Nov-Dec;26(6C):4775-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Secondary breast angiosarcoma: lethal response to anti-angiogenic therapy with paclitaxel chemotherapy. A case report.
  • Angiosarcoma of the breast is a malignant tumour of vascular endothelial cells.
  • The authors report a case of cutaneous radiation-associated angiosarcoma treated with paclitaxel chemotherapy.
  • [MeSH-major] Breast Neoplasms / chemically induced. Hemangiosarcoma / chemically induced. Neoplasms, Second Primary / chemically induced. Paclitaxel / adverse effects
  • [MeSH-minor] Aged, 80 and over. Carcinoma, Ductal, Breast / drug therapy. Carcinoma, Ductal, Breast / pathology. Female. Humans

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  • (PMID = 17214340.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] P88XT4IS4D / Paclitaxel
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33. Peramiquel L, Barnadas MA, Sancho J, Curell R, Alonso MC, Fuentes MJ, Pernas S, Gómez A, Alomar A: [Angiosarcoma in an irradiated breast: a case description]. Actas Dermosifiliogr; 2005 Nov;96(9):602-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Angiosarcoma in an irradiated breast: a case description].
  • [Transliterated title] Angiosarcoma en mama irradiada: descripción de un caso.
  • Post-radiotherapy cutaneous angiosarcomas have been described in different locations, including the breast.
  • We present a case of cutaneous angiosarcoma of the breast, diagnosed 6 years after a carcinoma of the breast had been treated with radiation.
  • The patient was a 44-year-old female with a history of ductal carcinoma (CA) of the right breast treated with tumorectomy, axillary lymphadenectomy, chemotherapy (FEC) and radiotherapy, who 6 years later presented with a violaceous, indurated plaque with a satellite nodule on the same breast.
  • Considering the patient's symptoms, history and the changes observed via mammography, it was decided to completely excise the lesion followed by a simple mastectomy, with the diagnosis of angiosarcoma being confirmed.
  • Despite this fact, two years and one month later, the angiosarcoma recurred on the internal area of the mastectomy scar.
  • This complication usually appears 5-10 years after treatment with radiotherapy, so angiosarcoma should be ruled out if any angiomatous lesions later appear on skin that had been irradiated.
  • [MeSH-major] Breast Neoplasms / etiology. Breast Neoplasms / radiotherapy. Carcinoma, Ductal, Breast / radiotherapy. Hemangiosarcoma / etiology. Neoplasms, Radiation-Induced / etiology. Skin Neoplasms / etiology

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  • (PMID = 16476306.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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34. Park JW, Serafica-Karen C, Das K: Fine-needle aspiration of metastatic radiation-induced cutaneous epithelioid angiosarcoma of the breast to the liver: A diagnostic dilemma. Diagn Cytopathol; 2010 Oct;38(10):768-71
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  • [Title] Fine-needle aspiration of metastatic radiation-induced cutaneous epithelioid angiosarcoma of the breast to the liver: A diagnostic dilemma.
  • Radiation therapy is a significant risk factor for the development of angiosarcoma.
  • With the increase in breast conservation treatment, the incidence of cutaneous radiation-induced angiosarcoma of the breast is rising.
  • If the angiosarcoma demonstrates epithelioid features, the tumor cells may present a diagnostic dilemma on fine-needle aspiration cytology.
  • We present a case of metastatic radiation-induced cutaneous epithelioid angiosarcoma of the breast to the liver and a review of the literature.
  • [MeSH-minor] Breast Neoplasms / metabolism. Breast Neoplasms / secondary. Carcinoma in Situ / radiotherapy. Carcinoma in Situ / surgery. Carcinoma, Ductal, Breast / radiotherapy. Carcinoma, Ductal, Breast / surgery. Cytodiagnosis. Diagnosis, Differential. Female. Hemangiosarcoma / metabolism. Hemangiosarcoma / secondary. Humans. Immunohistochemistry. Mastectomy, Segmental. Middle Aged. Radiotherapy, Adjuvant / adverse effects. Skin Neoplasms / metabolism. Skin Neoplasms / pathology

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  • [Copyright] © 2010 Wiley-Liss, Inc.
  • (PMID = 20187111.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] Angiosarcoma of the breast
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35. Nakamura R, Nagashima T, Sakakibara M, Nakano S, Tanabe N, Fujimoto H, Arai M, Kadowaki M, Oide T, Tanizawa T, Miyazaki M: Angiosarcoma arising in the breast following breast-conserving surgery with radiation for breast carcinoma. Breast Cancer; 2007;14(2):245-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma arising in the breast following breast-conserving surgery with radiation for breast carcinoma.
  • We report a case of angiosarcoma arising in the breast following breast-conserving surgery with radiation therapy for breast carcinoma.
  • The patient, a 49-year-old postmenopausal woman, had undergone breast-conserving surgery for invasive ductal carcinoma of the left breast (pT2 pN0 M0 Stage IIA).
  • Adjuvant radiotherapy (50 Gy with a booster dose to the tumor bed of 10 Gy) was then performed for the residual breast tissue and the patient was treated with hormone therapy (tamoxifen, 20 mg daily) for 5 years.
  • Incisional biopsy revealed angiosarcoma of the breast, and total mastectomy was subsequently performed.
  • [MeSH-major] Breast Neoplasms / pathology. Hemangiosarcoma / pathology. Mastectomy, Segmental. Neoplasms, Second Primary / pathology
  • [MeSH-minor] Carcinoma, Ductal, Breast / therapy. Chemotherapy, Adjuvant. Female. Humans. Mastectomy. Middle Aged. Radiotherapy, Adjuvant. Selective Estrogen Receptor Modulators / therapeutic use. Tamoxifen / therapeutic use

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  • (PMID = 17485913.001).
  • [ISSN] 1340-6868
  • [Journal-full-title] Breast cancer (Tokyo, Japan)
  • [ISO-abbreviation] Breast Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Selective Estrogen Receptor Modulators; 094ZI81Y45 / Tamoxifen
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36. Hanasono MM, Osborne MP, Dielubanza EJ, Peters SB, Gayle LB: Radiation-induced angiosarcoma after mastectomy and TRAM flap breast reconstruction. Ann Plast Surg; 2005 Feb;54(2):211-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Radiation-induced angiosarcoma after mastectomy and TRAM flap breast reconstruction.
  • Radiation-induced angiosarcoma of the breast is being reported with increasing frequency as a result of the increased use of radiation therapy in conjunction with breast conservation surgery.
  • The authors present a case of angiosarcoma occurring in a patient 6 years after undergoing mastectomy for invasive duct carcinoma with immediate transverse rectus abdominis musculocutaneous flap reconstruction followed by postoperative radiation therapy.
  • The diagnosis of angiosarcoma was made by skin biopsy performed by the patient's reconstructive surgeon on routine follow-up examination.
  • This is the first reported case of postradiation angiosarcoma occurring in a postmastectomy breast reconstructed with autogenous tissue and it is unusual in that the cancer invaded the musculocutaneous flap.
  • Diagnosis and management recommendations for radiation-induced angiosarcoma are discussed.
  • [MeSH-major] Breast Neoplasms / surgery. Carcinoma, Ductal, Breast / surgery. Hemangiosarcoma / etiology. Mastectomy, Modified Radical. Neoplasms, Radiation-Induced / surgery

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  • (PMID = 15655476.001).
  • [ISSN] 0148-7043
  • [Journal-full-title] Annals of plastic surgery
  • [ISO-abbreviation] Ann Plast Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ki-67 Antigen
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37. Markidou S, Karydas I, Papadopoulos S, Christodoulidou I, Skarpidi E, Maounis N: Fine needle aspiration cytology in primary breast angiosarcoma: a case report. Acta Cytol; 2010 Sep-Oct;54(5 Suppl):764-70
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  • [Title] Fine needle aspiration cytology in primary breast angiosarcoma: a case report.
  • BACKGROUND: Angiosarcoma of the breast is an uncommon, aggressive, vascular tumor.
  • CASE: The present study describes a case of breast angiosarcoma initially diagnosed by fine needle aspiration cytology.
  • Angiosarcoma appeared in the left breast of a 58-year-old woman after 12 years of a mastectomy (without radiotherapy) of the contralateral breast for invasive ductal carcinoma.
  • The diagnosis of angiosarcoma was confirmed by histopathology of the surgically excised tumor.
  • CONCLUSION: Angiosarcoma rarely occurs in the breast, and a definitive diagnosis is extremely difficult relying exclusively on cytologic features.
  • Predominance of epithelioid cells may suggest an epithelial tumor, especially in patients with a history of breast carcinoma, whereas predominance of spindle cells can be misinterpreted as phyllodes tumor or another type of sarcoma.
  • Cell block immunocytochemistry and tumor cell labeling with endothelial markers are necessary for accurate diagnosis.
  • [MeSH-major] Breast / pathology. Breast Neoplasms / pathology. Hemangiosarcoma / pathology
  • [MeSH-minor] Biopsy, Fine-Needle. Diagnosis, Differential. Epithelial Cells / pathology. Female. Humans. Immunohistochemistry. Mastectomy. Middle Aged

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  • (PMID = 21053536.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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38. Rodríguez-Bujaldón A, Vázquez-Bayo MC, Galán-Gutiérrez M, Jiménez-Puya R, Vélez García-Nieto A, Moreno-Giménez JC, Vidal-Jiménez A, Barroso-Casamitjana E: [Angiosarcoma in chronic lymphedema]. Actas Dermosifiliogr; 2006 Oct;97(8):525-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Angiosarcoma in chronic lymphedema].
  • [Transliterated title] Angiosarcoma sobre linfedema crónico.
  • Angiosarcoma that develops on a limb with chronic lymphedema is called Stewart-Treves syndrome.
  • This typically appears as a complication of a long course lymphedema located on the arm, after mastectomy and/or radiotherapy due to breast cancer.
  • There are cases of Stewart-Treves syndrome in chronic lymphedema in the upper limb contralateral to the breast treated for cancer and in chronic lymphedema of the leg.
  • The first corresponds to a typical syndrome of Stewart-Treves in an 83-year-old woman who was diagnosed of angiosarcoma in a chronic lymphedema territory secondary to mastectomy and radiotherapy due to breast cancer.
  • The second case is much rarer, since it is a case of diffuse angiosarcoma of the leg in a 42-year-old man with a history of lymphedema.
  • [MeSH-major] Hemangiosarcoma / etiology. Lymphedema / complications
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antibiotics, Antineoplastic / administration & dosage. Antibiotics, Antineoplastic / therapeutic use. Antineoplastic Agents, Alkylating / administration & dosage. Antineoplastic Agents, Alkylating / therapeutic use. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Arm. Doxorubicin / administration & dosage. Doxorubicin / therapeutic use. Female. Humans. Ifosfamide / administration & dosage. Ifosfamide / therapeutic use. Immunohistochemistry. Leg. Male. Skin / pathology. Skin Neoplasms / diagnosis. Skin Neoplasms / drug therapy. Skin Neoplasms / etiology. Skin Neoplasms / pathology. Skin Neoplasms / radiotherapy. Treatment Outcome

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  • (PMID = 17067532.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Antineoplastic Agents, Alkylating; 80168379AG / Doxorubicin; UM20QQM95Y / Ifosfamide
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39. Kunkel T, Mylonas I, Mayr D, Friese K, Sommer HL: Recurrence of secondary angiosarcoma in a patient with post-radiated breast for breast cancer. Arch Gynecol Obstet; 2008 Nov;278(5):497-501
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recurrence of secondary angiosarcoma in a patient with post-radiated breast for breast cancer.
  • INTRODUCTION: Angiosarcoma of the breast is a rare finding.
  • Two different subtypes of angiosarcomas have been described: (a) the Stewart-Treves syndrome and (b) the cutaneous post-radiation angiosarcoma.
  • We report a case where both types of angiosarcoma occurred.
  • CASE REPORT: At first, an angiosarcoma affecting parenchyma of the breast was observed after radiotherapy following breast conserving therapy and a history of lymphoedema of the radiated area.
  • Additionally, a subsequent local recurrence of the angiosarcoma of the skin after mastectomy and complete resection of the primary angiosarcoma was diagnosed.
  • Additionally, every oncologist should be aware of this rare complication as quick diagnosis and prompt surgical treatment is indispensable due to the aggressive entity of angiosarcoma.
  • [MeSH-major] Breast Neoplasms / therapy. Hemangiosarcoma / therapy. Neoplasm Recurrence, Local / therapy. Skin Neoplasms / therapy

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  • (PMID = 18305948.001).
  • [ISSN] 0932-0067
  • [Journal-full-title] Archives of gynecology and obstetrics
  • [ISO-abbreviation] Arch. Gynecol. Obstet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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40. Kiyozuka Y, Koyama H, Nakata M, Matsuyama T, Nikaido Y, Shimano N, Tsubura A: Diagnostic cytopathology in type II angiosarcoma of the breast: a case report. Acta Cytol; 2005 Sep-Oct;49(5):560-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnostic cytopathology in type II angiosarcoma of the breast: a case report.
  • BACKGROUND: The rare occurrence of angiosarcoma of the breast is reflected in limited descriptions of fine needle aspiration (FNA) cytomorphologic findings in this neoplasm.
  • We present a case of angiosarcoma of the breast and discuss the pitfalls in diagnostic cytopathology that can potentially lead to incorrect diagnoses in such cases.
  • CASE: A 45-year-old woman presented with a 2-year history of a right-sided breast mass.
  • The overall cytologic diagnosis was inconclusive but suggested phyllodes tumor (of borderline malignancy).
  • Histologic features were consistent with angiosarcoma, a diagnosis that was supported by immunohistochemical studies.
  • Angiosarcoma rarely occurs in the breast, and a definitive diagnosis is difficult based on cytologic examination of hypocellular smears alone.
  • [MeSH-major] Blood Vessels / pathology. Breast Neoplasms / pathology. Hemangiosarcoma / pathology. Mammary Glands, Human / blood supply. Mammary Glands, Human / pathology

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  • (PMID = 16334037.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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41. Glazebrook KN, Magut MJ, Reynolds C: Angiosarcoma of the breast. AJR Am J Roentgenol; 2008 Feb;190(2):533-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma of the breast.
  • OBJECTIVE: This article describes the imaging findings, pathologic correlation, and clinical presentation of rare primary and secondary angiosarcomas of the breast.
  • CONCLUSION: With the increasing use of breast conservation therapy for breast cancer, reports of postirradiation angiosarcoma have increased.
  • Both primary and secondary angiosarcomas may present with bruiselike skin discoloration, which may delay the diagnosis.
  • [MeSH-major] Breast Neoplasms / diagnosis. Diagnostic Imaging / methods. Hemangiosarcoma / diagnosis. Image Enhancement / methods

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  • (PMID = 18212243.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 18
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42. Lai MH, Lui CY: Mammary angiosarcoma in two patients at either end of the age spectrum. Hong Kong Med J; 2010 Apr;16(2):141-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mammary angiosarcoma in two patients at either end of the age spectrum.
  • Angiosarcoma of the breast is rare and has a poor prognosis due to its aggressive nature.
  • One is an 18-year-old woman who presented with a rapidly enlarging breast mass, and the other a 72-year-old woman whose breast mass was found during screening mammography.
  • The radiological features of mammary angiosarcoma are summarised in this report.

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  • (PMID = 20354250.001).
  • [ISSN] 1024-2708
  • [Journal-full-title] Hong Kong medical journal = Xianggang yi xue za zhi
  • [ISO-abbreviation] Hong Kong Med J
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
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43. Ortiz Mendoza CM: [Recurrent breast haematoma after fine needle aspiration biopsy of angiosarcoma]. Ginecol Obstet Mex; 2007 Mar;75(3):164-7
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  • [Title] [Recurrent breast haematoma after fine needle aspiration biopsy of angiosarcoma].
  • [Transliterated title] Hematoma mamario recidivante posterior a la biopsia por aspiración con aguja delgada en un angiosarcoma.
  • It is reported a rare complication after a fine needle aspiration biopsy of a breast angiosarcoma.
  • A 30-years-old female presented with a right breast lump.
  • A fine needle aspiration biopsy was carried out for diagnosis, but only blood was report.
  • A capillary and cavernous breast hemangioma was diagnosed.
  • Four months later a recurrence presented, and a new excision was carried out with a resulting moderately differentiated angiosarcoma, then a simple mastectomy was performed for definitive treatment.
  • A recurrent haematoma after a fine needle aspiration biopsy of a breast tumor mandates to rule out an angiosarcoma.
  • [MeSH-major] Biopsy, Fine-Needle / adverse effects. Breast / injuries. Breast Neoplasms / pathology. Hemangiosarcoma / pathology. Hematoma / etiology

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  • (PMID = 17547091.001).
  • [ISSN] 0300-9041
  • [Journal-full-title] Ginecología y obstetricia de México
  • [ISO-abbreviation] Ginecol Obstet Mex
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Mexico
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44. Fodor J, Orosz Z, Szabó E, Sulyok Z, Polgár C, Zaka Z, Major T: Angiosarcoma after conservation treatment for breast carcinoma: our experience and a review of the literature. J Am Acad Dermatol; 2006 Mar;54(3):499-504
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  • [Title] Angiosarcoma after conservation treatment for breast carcinoma: our experience and a review of the literature.
  • The development of angiosarcoma of the breast is a recognized complication of breast conservation therapy (BCT), but the evolution, prevalence, and outcome have not been accurately established.
  • We sought to evaluate and review the clinicopathologic, prognostic, and treatment attributes of angiosarcoma arising in the irradiated breast after BCT.
  • We conducted a retrospective chart and slide review of 8 patients seen between 1996 and 2004 with a diagnosis of secondary angiosarcoma.
  • Primary surgery-related breast edema and cellulitis was observed in 7 and 5 patients of the 8 patients studied, respectively.
  • Postirradiation breast edema and grade 2/3 fibrosis occurred in 5 and 8 patients, respectively.
  • The mean age of the patients at onset of the breast cancer and angiosarcoma was 65 and 72 years, respectively.
  • The mean latency period between the treatment of the breast cancer and the diagnosis of angiosarcoma was 75 months.
  • The estimated incidence of angiosarcoma after BCT was found to be 0.14 %.
  • BCT-associated angiosarcoma arises after a relatively brief interval, and breast edema-fibrosis can possibly contribute to its development.
  • As shown by a review of the literature, angiosarcomas are often resistant to surgery, chemotherapy, and radiotherapy, and targeted therapy against tumor biological properties may be a new approach to angiosarcoma treatment.
  • [MeSH-major] Breast Neoplasms / etiology. Breast Neoplasms / therapy. Hemangiosarcoma / etiology. Neoplasms, Second Primary / etiology

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  • (PMID = 16488303.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 41
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45. Pfeiffer DF, Bode-Lesniewska B: Fine needle aspiration biopsy diagnosis of angiosarcoma after breast-conserving therapy for carcinoma supported by use of a cell block and immunohistochemistry. Acta Cytol; 2006 Sep-Oct;50(5):553-6
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  • [Title] Fine needle aspiration biopsy diagnosis of angiosarcoma after breast-conserving therapy for carcinoma supported by use of a cell block and immunohistochemistry.
  • BACKGROUND: Angiosarcoma is a rare malignant soft tissue tumor occurring at various sites as either a primary or secondary event.
  • Primary angiosarcoma of the breast is an unusual tumor, counting for 1 in 1700-2,000 primary malignant tumors of this organ.
  • An increasing number of secondary angiosarcomas involving skin and breast.
  • CASE: Angiosarcoma arose 6 years after breast-conserving therapy for invasive carcinoma in a 69-year-old woman.
  • Fine needle aspiration of several small, reddish, intradermal nodules over the treated area revealed malignant cells with an endothelial immunophenotype in the cel block, yielding the diagnosis of angiosarcoma, subsequently confired in a mastectomy speciman.
  • CONCLUSION: Fine needle aspiration, supported by ancillary techniques, such as cell block and immunohistochemistry, allows the cytologic diagnosis of an angiosarcoma and differentiates it from a carcinoma recurrence.
  • [MeSH-major] Breast / pathology. Breast Neoplasms / diagnosis. Carcinoma, Ductal, Breast / diagnosis. Hemangiosarcoma / diagnosis. Neoplasms, Second Primary / diagnosis. Radiotherapy / adverse effects
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Biomarkers, Tumor / metabolism. Biopsy, Fine-Needle. Cell Nucleus / pathology. Diagnosis, Differential. Epithelial Cells / pathology. Female. Humans. Immunohistochemistry / methods. Neoplasm Recurrence, Local / diagnosis

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  • (PMID = 17017445.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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46. Muzumder S, Das P, Kumar M, Bhasker S, Sarkar C, Medhi K, Iyer VK, Rath GK: Primary epithelioid angiosarcoma of the breast masquerading as carcinoma. Curr Oncol; 2010 Feb;17(1):64-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary epithelioid angiosarcoma of the breast masquerading as carcinoma.
  • Here we report a case of primary epithelioid angiosarcoma (eas) of the breast occurring in a 30-year-old woman.
  • Postoperative histopathologic examination and immunohistochemistry revealed a diagnosis of primary epithelioid angiosarcoma of the breast.
  • Indeed, this is an area of potential diagnostic error because, nowadays, neoadjuvant therapy is often instituted after core biopsy of a breast mass.

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  • (PMID = 20179806.001).
  • [ISSN] 1718-7729
  • [Journal-full-title] Current oncology (Toronto, Ont.)
  • [ISO-abbreviation] Curr Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC2826780
  • [Keywords] NOTNLM ; Breast / primary epithelioid angiosarcoma
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47. Abbott R, Palmieri C: Angiosarcoma of the breast following surgery and radiotherapy for breast cancer. Nat Clin Pract Oncol; 2008 Dec;5(12):727-36
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma of the breast following surgery and radiotherapy for breast cancer.
  • Breast angiosarcoma following surgery and radiotherapy for breast cancer is a rare but important clinical entity.
  • This article reviews all published cases and includes data on incidence, etiology, presentation, diagnosis, management and prognosis.
  • Breast angiosarcoma remains challenging clinically, radiologically and histologically, and thus a high index of suspicion is required in susceptible patients.
  • [MeSH-major] Breast Neoplasms / epidemiology. Hemangiosarcoma / epidemiology. Neoplasm Recurrence, Local / epidemiology. Neoplasms, Radiation-Induced

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  • (PMID = 18936792.001).
  • [ISSN] 1743-4262
  • [Journal-full-title] Nature clinical practice. Oncology
  • [ISO-abbreviation] Nat Clin Pract Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 90
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48. Kikawa Y, Konishi Y, Nakamoto Y, Harada T, Takeo M, Ogata M, Yamamoto M, Usuki N, Toyoshima M, Katsuyama E: Angiosarcoma of the breast - specific findings of MRI. Breast Cancer; 2006;13(4):369-73
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma of the breast - specific findings of MRI.
  • We present a case of low-grade angiosarcoma of the breast.
  • A 26-year old woman presented with a lump in the left breast.
  • An elastic hard and ill-defined tumor, 80 x 50 mm in size, was palpated in the upper region of her left breast.
  • Therefore, she was followed with a diagnosis of mastopathy.
  • A contrast-enhanced MRI of the breast was performed.
  • Core needle biopsy was performed, and a possible angiosarcoma was diagnosed.
  • It is not easy to diagnose the mammary angiosarcoma.
  • MRI may contribute to the accurate diagnosis and play an important role regarding this entity.
  • [MeSH-major] Breast Neoplasms / diagnosis. Hemangiosarcoma / diagnosis. Magnetic Resonance Imaging

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  • (PMID = 17146165.001).
  • [ISSN] 1340-6868
  • [Journal-full-title] Breast cancer (Tokyo, Japan)
  • [ISO-abbreviation] Breast Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Organometallic Compounds; 1BJ477IO2L / gadobutrol
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49. Vogt T: [Angiosarcoma]. Hautarzt; 2008 Mar;59(3):237-48; quiz 249-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Angiosarcoma].
  • [Transliterated title] Angiosarkom.
  • Angiosarcoma favors superficial soft tissues and skin (60%) with a clear predilection for the head and neck region.
  • Secondary angiosarcoma after tissue-conserving radiation therapy for carcinoma of the breast represents an increasing problem, both the differentiation between atypical vascular lesions and true aggressive angiosarcoma and the therapy are challenging.
  • The prognosis for angiosarcoma patients is gloomy despite all therapeutic efforts.
  • [MeSH-major] Hemangiosarcoma / diagnosis. Hemangiosarcoma / therapy. Skin Neoplasms / diagnosis. Skin Neoplasms / therapy

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  • (PMID = 18273583.001).
  • [ISSN] 1432-1173
  • [Journal-full-title] Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
  • [ISO-abbreviation] Hautarzt
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 27
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50. Young RJ, Brown NJ, Reed MW, Hughes D, Woll PJ: Angiosarcoma. Lancet Oncol; 2010 Oct;11(10):983-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma.
  • They can be caused by therapeutic radiation or chronic lymphoedema and hence secondary breast angiosarcomas are an important subgroup.
  • In this review we discuss angiosarcoma and its current management, with a focus on clinical trials investigating the treatment of advanced disease.
  • [MeSH-major] Hemangiosarcoma / therapy
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Male. Neoplasm Staging. Predictive Value of Tests. Risk Factors. Treatment Outcome

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  • [Copyright] Copyright © 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20537949.001).
  • [ISSN] 1474-5488
  • [Journal-full-title] The Lancet. Oncology
  • [ISO-abbreviation] Lancet Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
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51. Luini A, Gatti G, Diaz J, Botteri E, Oliveira E, Cecilio Sahium de Almeida R, Veronesi P, Intra M, Pagani G, Naninato P, Viale G: Angiosarcoma of the breast: the experience of the European Institute of Oncology and a review of the literature. Breast Cancer Res Treat; 2007 Sep;105(1):81-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma of the breast: the experience of the European Institute of Oncology and a review of the literature.
  • Angiosarcoma of the breast (AB) is a rare entity: its overall incidence is estimated at between 0.002% and 0.005% per year.
  • Some potential risk factors have been described, mainly previous irradiation of the breast.
  • We report the experience of the European Institute of Oncology with this unusual disease from January 1996 to January 2006: sixteen patients with angiosarcoma, 9 (56%) of whom had primary AB and 7 (44%), secondary AB, are discussed.
  • [MeSH-major] Breast Neoplasms / diagnosis. Hemangiosarcoma / diagnosis
  • [MeSH-minor] Adult. Aged. Disease-Free Survival. Europe. Female. Humans. Middle Aged. Retrospective Studies. Risk Factors. Sarcoma / diagnosis. Sarcoma / pathology. Sarcoma / radiotherapy. Soft Tissue Neoplasms / diagnosis. Soft Tissue Neoplasms / pathology. Soft Tissue Neoplasms / radiotherapy. Time Factors

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  • (PMID = 17115110.001).
  • [ISSN] 0167-6806
  • [Journal-full-title] Breast cancer research and treatment
  • [ISO-abbreviation] Breast Cancer Res. Treat.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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52. Shet T, Malaviya A, Nadkarni M, Kakade A, Parmar V, Badwe R, Chinoy R: Primary angiosarcoma of the breast: observations in Asian Indian women. J Surg Oncol; 2006 Oct 1;94(5):368-74
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary angiosarcoma of the breast: observations in Asian Indian women.
  • BACKGROUND: Primary angiosarcomas of breast are rare tumors, with a fatal outcome.
  • RESULTS: All patients had primary angiosarcoma; no case of secondary angiosarcoma was accessioned during the study period.
  • Interesting cases encountered included an epithelioid angiosarcoma and an angiosarcoma arising on the background of a biphasic tumor.
  • The patient with well-differentiated angiosarcoma also died of metastasis albeit after a longer time.
  • CONCLUSION: Primary angiosarcoma was fatal in young Indian women even in lower grade tumors.
  • [MeSH-major] Breast Neoplasms / pathology. Hemangiosarcoma / pathology. Proto-Oncogene Proteins c-kit / biosynthesis

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  • [Copyright] Copyright (c) 2006 Wiley-Liss, Inc.
  • (PMID = 16967461.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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53. Taib N, Yip Ch, Ranganathan S, Moosa F, Mun K: Haemorrhaging lesion in the breast: is there a role for embolisation? Biomed Imaging Interv J; 2006 Jul;2(3):e30

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Haemorrhaging lesion in the breast: is there a role for embolisation?
  • Angiosarcoma of the breast is an extremely rare condition.
  • This case illustrates the use of embolisation as a modality of treatment for primary breast angiosarcoma.

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  • [Cites] Rofo. 2001 Aug;173(8):763-5 [11570248.001]
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  • (PMID = 21614243.001).
  • [ISSN] 1823-5530
  • [Journal-full-title] Biomedical imaging and intervention journal
  • [ISO-abbreviation] Biomed Imaging Interv J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Malaysia
  • [Other-IDs] NLM/ PMC3097628
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54. Nascimento AF, Raut CP, Fletcher CD: Primary angiosarcoma of the breast: clinicopathologic analysis of 49 cases, suggesting that grade is not prognostic. Am J Surg Pathol; 2008 Dec;32(12):1896-904
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary angiosarcoma of the breast: clinicopathologic analysis of 49 cases, suggesting that grade is not prognostic.
  • Mammary angiosarcoma is a rare neoplasm, accounting for about 0.05% of all primary malignancies of the breast.
  • Forty-nine cases of primary angiosarcoma of the breast were retrieved from our files.
  • All tumors examined were located within breast parenchyma with or without minor cutaneous involvement.
  • Two patients had a history of prior radiation treatment for breast carcinoma.
  • Ten patients (24.4%) showed evidence of local recurrence within 11 to 60 months (median 36) after diagnosis.
  • Time interval between diagnosis and metastasis ranged from 2 to 144 months (median 34).
  • Eighteen patients (44%) so far have died of disease and 1 died of presumably disseminated breast carcinoma.
  • In conclusion, mammary angiosarcoma is a rare disease that affects relatively younger patients.
  • This tumor seems to have an overall similar clinical course as other types of angiosarcoma arising in skin or soft tissue; it carries a moderate risk of local recurrence, and a high risk of metastasis and death.
  • [MeSH-major] Breast Neoplasms / pathology. Hemangiosarcoma / pathology

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  • (PMID = 18813119.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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55. Gambini D, Visintin R, Locatelli E, Galassi B, Bareggi C, Runza L, Onida F, Tomirotti M: Paclitaxel-dependent prolonged and persistent complete remission four years from first recurrence of secondary breast angiosarcoma. Tumori; 2009 Nov-Dec;95(6):828-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Paclitaxel-dependent prolonged and persistent complete remission four years from first recurrence of secondary breast angiosarcoma.
  • Among angiosarcomas, radiation-induced breast sarcomas (RIBS) represent a well-known entity generally characterized by a poor outcome, especially in patients with advanced disease.
  • We report a case of a patient having a secondary breast angiosarcoma recurring early after surgery, who achieved complete remission following treatment with weekly paclitaxel.
  • [MeSH-major] Angiogenesis Inhibitors / therapeutic use. Antineoplastic Agents, Phytogenic / therapeutic use. Breast Neoplasms / drug therapy. Hemangiosarcoma / drug therapy. Mastectomy, Segmental. Neoplasm Recurrence, Local / drug therapy. Paclitaxel / therapeutic use

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  • (PMID = 20210253.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Antineoplastic Agents, Phytogenic; P88XT4IS4D / Paclitaxel
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56. Sher T, Hennessy BT, Valero V, Broglio K, Woodward WA, Trent J, Hunt KK, Hortobagyi GN, Gonzalez-Angulo AM: Primary angiosarcomas of the breast. Cancer; 2007 Jul 1;110(1):173-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary angiosarcomas of the breast.
  • BACKGROUND: The purpose of the study was to describe the clinicopathologic characteristics and clinical outcomes of patients with primary breast angiosarcoma.
  • METHODS: The institutional database was searched to identify breast angiosarcoma patients seen between 1965 and 2002.
  • Median tumor size at diagnosis was 5.5 cm.
  • Thirteen (18.8%) patients received prior radiation for invasive breast carcinoma.
  • CONCLUSIONS: Breast angiosarcoma is frequently advanced at diagnosis and has a tendency for local-regional recurrence.
  • [MeSH-major] Breast Neoplasms / pathology. Hemangiosarcoma / pathology

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  • [Copyright] Copyright (c) 2007 American Cancer Society.
  • (PMID = 17541936.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / L30 CA123630; United States / NCI NIH HHS / CA / L30 CA123630-01; United States / NCI NIH HHS / CA / L30 CA123630-02
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Estrogen; 0 / Receptors, Progesterone
  • [Other-IDs] NLM/ NIHMS283619; NLM/ PMC4329779
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57. Mano MS, Fraser G, Kerr J, Gray M, Evans V, Kazmi A, Canney P: Radiation-induced angiosarcoma of the breast shows major response to docetaxel after failure of anthracycline-based chemotherapy. Breast; 2006 Feb;15(1):117-8
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  • [Title] Radiation-induced angiosarcoma of the breast shows major response to docetaxel after failure of anthracycline-based chemotherapy.
  • We report on the case of a patient with a diagnosis of an uncommon breast tumour, namely a radiation-induced angiosarcoma, which was primarily refractory to anthracycline-based chemotherapy, but highly sensitive to docetaxel.
  • [MeSH-major] Antineoplastic Agents, Phytogenic / therapeutic use. Breast Neoplasms / drug therapy. Breast Neoplasms / etiology. Hemangiosarcoma / drug therapy. Hemangiosarcoma / etiology. Neoplasms, Radiation-Induced / drug therapy. Taxoids / therapeutic use

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  • (PMID = 16473744.001).
  • [ISSN] 0960-9776
  • [Journal-full-title] Breast (Edinburgh, Scotland)
  • [ISO-abbreviation] Breast
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; 0 / Taxoids; 15H5577CQD / docetaxel; 3Z8479ZZ5X / Epirubicin; 8N3DW7272P / Cyclophosphamide; U3P01618RT / Fluorouracil
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58. Hodgson NC, Bowen-Wells C, Moffat F, Franceschi D, Avisar E: Angiosarcomas of the breast: a review of 70 cases. Am J Clin Oncol; 2007 Dec;30(6):570-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcomas of the breast: a review of 70 cases.
  • OBJECTIVE: Angiosarcoma arising in the irradiated breast after breast-conserving therapy is being reported with increasing frequency.
  • As more women undergo breast-conserving therapy, the incidence can be expected to increase.
  • The objective of this study was to review breast angiosarcomas diagnosed from 1981 to 2000 from our state cancer registry.
  • METHODS: A comprehensive review of a population-based registry, Florida Cancer Data System, identified 70 cases of breast angiosarcomas from 1981 to 2000.
  • RESULTS: Of the 70 cases at presentation, 39 were primary breast angiosarcomas (PBAs) and 31 were secondary breast angiosarcomas (SBAs).
  • In the SBA group the mean age of breast cancer diagnosis was 67.6.
  • The mean time to diagnosis of the angiosarcoma was 5.2 years after breast cancer irradiation.
  • CONCLUSION: Angiosarcoma of the breast is rare and this study reports a review of 70 cases from 1980 to 2000.
  • Angiosarcoma after breast-conserving therapy is increasingly diagnosed in a small but significant portion of breast carcinoma survivors.
  • [MeSH-major] Breast Neoplasms / etiology. Hemangiosarcoma / etiology. Mastectomy, Segmental / adverse effects. Neoplasms, Second Primary / etiology

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  • (PMID = 18091049.001).
  • [ISSN] 1537-453X
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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59. Penel N, Bui BN, Bay JO, Cupissol D, Ray-Coquard I, Piperno-Neumann S, Kerbrat P, Fournier C, Taieb S, Jimenez M, Isambert N, Peyrade F, Chevreau C, Bompas E, Brain EG, Blay JY: Phase II trial of weekly paclitaxel for unresectable angiosarcoma: the ANGIOTAX Study. J Clin Oncol; 2008 Nov 10;26(32):5269-74
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Phase II trial of weekly paclitaxel for unresectable angiosarcoma: the ANGIOTAX Study.
  • PURPOSE: The objective of this phase II trial was to assess the efficacy and toxicity of weekly paclitaxel for patients with metastatic or unresectable angiosarcoma.
  • Three patients with locally advanced breast angiosarcoma presented partial response, which enabled a secondary curative-intent surgery with complete histologic response in two cases.
  • [MeSH-major] Antineoplastic Agents, Phytogenic / administration & dosage. Breast Neoplasms / drug therapy. Head and Neck Neoplasms / drug therapy. Hemangiosarcoma / drug therapy. Paclitaxel / administration & dosage. Scalp. Skin Neoplasms / drug therapy. Soft Tissue Neoplasms / drug therapy

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  • (PMID = 18809609.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; P88XT4IS4D / Paclitaxel
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60. Lucas DR: Angiosarcoma, radiation-associated angiosarcoma, and atypical vascular lesion. Arch Pathol Lab Med; 2009 Nov;133(11):1804-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma, radiation-associated angiosarcoma, and atypical vascular lesion.
  • Angiosarcoma, one of the least common sarcomas, has become increasingly important because of its association with radiation therapy, especially for breast cancer.
  • However, angiosarcoma has a wide anatomic distribution including soft tissue, visceral organ, and osseous locations.
  • Radiation-associated angiosarcoma typically presents as a cutaneous tumor several years posttherapy.
  • The latency for radiation-associated mammary angiosarcoma is relatively short, sometimes less than 3 years.
  • Although most atypical vascular lesions pursue a benign course, they recur and very rarely progress to angiosarcoma.
  • Distinguishing this lesion from well-differentiated angiosarcoma in a biopsy can be challenging, especially because areas indistinguishable from atypical vascular lesion are found adjacent to angiosarcoma.
  • [MeSH-major] Hemangioma / pathology. Hemangiosarcoma / pathology. Neoplasms, Radiation-Induced / pathology. Skin Neoplasms / pathology. Vascular Diseases / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Breast Neoplasms / radiotherapy. Female. Humans. Skin / blood supply

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  • (PMID = 19886715.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 12
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61. Andrews S, Wilcoxon R, Benda J, Jacobson G: Angiosarcoma following MammoSite partial breast irradiation. Breast Cancer Res Treat; 2010 Nov;124(1):279-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma following MammoSite partial breast irradiation.
  • Angiosarcoma is a rare tumor of endothelial origin which commonly arises in small blood or lymphatic vessels.
  • Its development in the treated breast following adjuvant external beam radiation is also rare.
  • To our knowledge, there are no reported cases in the literature or MammoSite registry which describe the occurrence of angiosarcoma in the treated breast following MammoSite brachytherapy.
  • This is a case report of a 74 year old female who developed angiosarcoma 4 years after receiving MammoSite balloon brachytherapy following surgical resection of a T1mic N0 M0 infiltrating ductal carcinoma.
  • [MeSH-major] Brachytherapy / adverse effects. Breast Neoplasms / radiotherapy. Carcinoma, Ductal, Breast / radiotherapy. Hemangiosarcoma / etiology. Neoplasms, Radiation-Induced / etiology

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  • (PMID = 20496164.001).
  • [ISSN] 1573-7217
  • [Journal-full-title] Breast cancer research and treatment
  • [ISO-abbreviation] Breast Cancer Res. Treat.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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62. Fodor J: [Evidence-based radiotherapy in the treatment of early-stage invasive breast cancer: traditional clinical features and biomarkers]. Magy Onkol; 2009 Mar;53(1):7-14
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  • [Title] [Evidence-based radiotherapy in the treatment of early-stage invasive breast cancer: traditional clinical features and biomarkers].
  • Adjuvant radiotherapy after modified radical mastectomy and breast-conserving surgery for early-stage invasive breast cancer substantially reduces the risk of locoregional failure and is evidence-based.
  • After mastectomy the chest wall, and after breast conserving surgery the ipsilateral breast are the sites at greatest risk of recurrence.
  • Patients with </=2 cm ipsilateral breast recurrence might receive a second conservative surgery.
  • The estimated incidence of ipsilateral breast angiosarcoma is less than 0.2%, but the mortality rate is high.
  • [MeSH-major] Biomarkers, Tumor / analysis. Breast Neoplasms / pathology. Breast Neoplasms / radiotherapy. Neoplasm Recurrence, Local / prevention & control. Radiation Injuries / etiology

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  • (PMID = 19318321.001).
  • [ISSN] 0025-0244
  • [Journal-full-title] Magyar onkologia
  • [ISO-abbreviation] Magy Onkol
  • [Language] hun
  • [Publication-type] Addresses; English Abstract
  • [Publication-country] Hungary
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Receptors, Estrogen; 0 / Receptors, Progesterone; EC 2.7.10.1 / Receptor, ErbB-2
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63. Mehta RS, Mikhail M: Post-irradiation cutaneous angiosarcoma. Cases J; 2008;1(1):241

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Post-irradiation cutaneous angiosarcoma.
  • Angiosarcoma is a rare and highly malignant tumor with potential to recur despite treatment, and carries a poor prognosis.
  • We present a case of cutaneous angiosarcoma which occurred at lumpectomy site in a patient with a history of breast cancer and radiation to the breast.
  • The tumor kept on recurring repetitively despite continual treatments, and the patient finally succumbed to the disease roughly four years after initial diagnosis.

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  • [Cites] Ann Surg Oncol. 2007 Jun;14(6):1953-67 [17356953.001]
  • [Cites] Cancer. 1994 May 15;73(10):2653-62 [8174066.001]
  • [Cites] Cancer. 1996 Jun 1;77(11):2400-6 [8635113.001]
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  • (PMID = 18925942.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2605761
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64. Lahat G, Dhuka AR, Lahat S, Smith KD, Pollock RE, Hunt KK, Ravi V, Lazar AJ, Lev D: Outcome of locally recurrent and metastatic angiosarcoma. Ann Surg Oncol; 2009 Sep;16(9):2502-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Outcome of locally recurrent and metastatic angiosarcoma.
  • BACKGROUND: Angiosarcoma (AS) is a rare soft tissue sarcoma with an enhanced propensity for local and systemic failure.
  • RESULTS: Forty-four patients were treated for locally recurrent AS; the majority (59%) were <or=5 cm; the most common sites were skin (48%) and breast (32%).
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Hemangiosarcoma / secondary. Neoplasm Recurrence, Local / pathology. Neoplasms / pathology

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  • (PMID = 19551444.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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65. Palta M, Morris CG, Grobmyer SR, Copeland EM 3rd, Mendenhall NP: Angiosarcoma after breast-conserving therapy: long-term outcomes with hyperfractionated radiotherapy. Cancer; 2010 Apr 15;116(8):1872-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma after breast-conserving therapy: long-term outcomes with hyperfractionated radiotherapy.
  • BACKGROUND: With breast-conserving therapy (BCT) as the standard of care for patients with noninvasive and early stage invasive breast cancer, a small incidence of post-BCT angiosarcoma has emerged.
  • The current study was conducted to report the long-term outcomes of a novel approach using hyperfractionated and accelerated radiotherapy (HART) for angiosarcoma developing after BCT.
  • METHODS: The authors retrospectively reviewed the outcomes of 14 patients treated with HART with or without surgery at the University of Florida between November 1997 and March 2006 for angiosarcoma that developed after BCT.
  • Five patients had further manifestations of angiosarcoma after HART at a median of 1 month (range, 1-28 months): 3 with progressive pulmonary and/or mediastinal disease that was likely present before HART and 2 with local or regional disease extension.
  • CONCLUSIONS: To the best of the authors' knowledge, HART with or without subsequent surgery, as documented in the current series, is the first approach to provide a high rate of local control, disease-free survival, and overall survival after the development of post-BCT angiosarcoma.
  • [MeSH-major] Breast Neoplasms / radiotherapy. Breast Neoplasms / surgery. Dose Fractionation. Hemangiosarcoma / cerebrospinal fluid. Hemangiosarcoma / radiotherapy

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  • [Copyright] (c) 2010 American Cancer Society.
  • (PMID = 20162708.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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66. West JG, Qureshi A, West JE, Chacon M, Sutherland ML, Haghighi B, Harrison J: Risk of angiosarcoma following breast conservation: a clinical alert. Breast J; 2005 Mar-Apr;11(2):115-23
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Risk of angiosarcoma following breast conservation: a clinical alert.
  • Approximately 100 cases of angiosarcoma following breast-conserving therapy have been reported.
  • The prevalence of angiosarcoma following breast conservation has not been accurately established and optimal treatment has not been defined.
  • The Fisher's exact test was used to compare the prevalence of postirradiation angiosarcoma seen in our private practice to the prevalence reported from the two largest national database studies.
  • The results of the comparison indicated that the prevalence of postirradiation angiosarcoma seen in our practice was significantly higher than that reported in the two national database studies at p-values of 0.0124 and 0.0080.
  • The data are insufficient to draw firm conclusions, but suggest that the current literature underestimates the prevalence of angiosarcoma following breast-conserving therapy.
  • Since elderly women derive less benefit from radiation and may be more prone to develop postirradiation angiosarcoma, confirmation of our findings could lead to a reappraisal of the management of elderly patients with early stage breast cancer.
  • [MeSH-major] Breast Neoplasms / epidemiology. Breast Neoplasms / therapy. Hemangiosarcoma / epidemiology. Hemangiosarcoma / etiology. Mastectomy, Segmental. Neoplasms, Radiation-Induced / epidemiology

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  • (PMID = 15730457.001).
  • [ISSN] 1075-122X
  • [Journal-full-title] The breast journal
  • [ISO-abbreviation] Breast J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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67. West JG, Weitzel JN, Tao ML, Carpenter M, West JE, Fanning C: BRCA mutations and the risk of angiosarcoma after breast cancer treatment. Clin Breast Cancer; 2008 Dec;8(6):533-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] BRCA mutations and the risk of angiosarcoma after breast cancer treatment.
  • Post-breast cancer treatment-related angiosarcomas were first observed in lymphedematous extremities after mastectomy and are now being reported with increasing frequency after lumpectomy and radiation.
  • A case history is presented of a BRCA2 carrier who had a postmastectomy chest wall angiosarcoma but had neither therapeutic radiation nor clinically evident lymphedema.
  • The absence of established risk factors led to speculation that the BRCA2 germline mutation could be a causative factor in the development of this patient's angiosarcoma.
  • [MeSH-major] BRCA2 Protein / genetics. Breast Neoplasms / surgery. Carcinoma, Ductal, Breast / surgery. Germ-Line Mutation. Hemangiosarcoma / genetics. Neoplasms, Second Primary / genetics. Skin Neoplasms / genetics

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  • (PMID = 19073510.001).
  • [ISSN] 1526-8209
  • [Journal-full-title] Clinical breast cancer
  • [ISO-abbreviation] Clin. Breast Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / BRCA2 Protein
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68. Chopra S, Ors F, Bergin D: MRI of angiosarcoma associated with chronic lymphoedema: Stewart Treves syndrome. Br J Radiol; 2007 Dec;80(960):e310-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] MRI of angiosarcoma associated with chronic lymphoedema: Stewart Treves syndrome.
  • Cutaneous angiosarcoma is a rare complication of a chronic lymphedematous extremity (Stewart-Treves syndrome).
  • This report describes the MRI appearance of Stewart-Treves syndrome in a patient with a background of lumpectomy, axillary node dissection and radiotherapy for breast carcinoma.
  • [MeSH-major] Lymphangiosarcoma / diagnosis. Lymphedema / complications. Skin Neoplasms / diagnosis
  • [MeSH-minor] Arm. Breast Neoplasms / surgery. Chronic Disease. Female. Humans. Lymph Node Excision / adverse effects. Magnetic Resonance Imaging. Middle Aged. Syndrome

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  • (PMID = 18065640.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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69. de Giorgi V, Santi R, Grazzini M, Papi F, Gori A, Rossari S, Massi D, Lotti T: Synchronous angiosarcoma, melanoma and morphea of the breast skin 14 years after radiotherapy for mammary carcinoma. Acta Derm Venereol; 2010 May;90(3):283-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Synchronous angiosarcoma, melanoma and morphea of the breast skin 14 years after radiotherapy for mammary carcinoma.
  • With the improvement in survival after breast cancer there has been increasing interest in the long-term effects of radiotherapy, including the development of tumours.
  • Compared with the general population, breast cancer survivors have a 10-50% higher risk of developing a second cancer.
  • We describe here the case of a 68-year-old woman who developed synchronous cutaneous angiosarcoma, melanoma and morphea of the breast skin and the local area, 14 years after radiotherapy for breast carcinoma.
  • Given the risk of post-radiation secondary primaries in breast cancer patients, long-term surveillance is necessary, with particular attention being paid to skin changes in the irradiation field.
  • [MeSH-major] Breast Neoplasms / radiotherapy. Carcinoma / radiotherapy. Hemangiosarcoma / etiology. Melanoma / etiology. Neoplasms, Radiation-Induced / etiology. Neoplasms, Second Primary / etiology. Scleroderma, Localized / etiology. Skin Neoplasms / etiology


70. Gherardi G, Rossi S, Perrone S, Scanni A: Angiosarcoma after breast-conserving therapy: fine-needle aspiration biopsy, immunocytochemistry, and clinicopathologic correlates. Cancer; 2005 Jun 25;105(3):145-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma after breast-conserving therapy: fine-needle aspiration biopsy, immunocytochemistry, and clinicopathologic correlates.
  • BACKGROUND: Angiosarcoma that arises after breast-conserving therapy can present clinically as a cutaneous and/or subcutaneous breast lump, which is misinterpreted easily as a recurrence of carcinoma.
  • To the authors' knowledge, the role of fine-needle aspiration (FNA) cytology in the early diagnosis of this life-threatening complication of breast carcinoma therapy has not been established fully.
  • METHODS: The authors studied three new patients with this type of secondary angiosarcoma diagnosed by FNA biopsy and immunocytochemistry, reviewed the literature on the topic, and examined relevant differential diagnostic issues.
  • RESULTS: Patients presented with a discrete skin lump that had arisen several years after breast-conservative therapy for early-stage breast carcinoma near the scar from the previous surgery.
  • Immunostaining of smears, however, provided conclusive evidence of the endothelial differentiation of tumor cells, and an FNA diagnosis of angiosarcoma was rendered in all patients.
  • The histopathology of all surgically excised tumors confirmed the diagnosis of high-grade angiosarcoma.
  • CONCLUSIONS: Based on the authors' experience, the FNA cytologic appearance of angiosarcoma that presented as a breast skin nodule in a breast carcinoma survivor easily could have been misinterpreted as carcinoma.
  • A correct diagnosis of this tumor relies on the proper evaluation of clinical findings and, as also shown by a review of the literature, requires immunocytochemical evidence of endothelial differentiation.
  • [MeSH-major] Biopsy, Fine-Needle. Breast Neoplasms / pathology. Breast Neoplasms / surgery. Hemangiosarcoma / secondary. Mastectomy, Segmental / adverse effects. Skin Neoplasms / secondary
  • [MeSH-minor] Aged. Aged, 80 and over. Carcinoma in Situ / pathology. Carcinoma in Situ / surgery. Carcinoma, Ductal, Breast / secondary. Carcinoma, Ductal, Breast / surgery. Carcinoma, Lobular / secondary. Carcinoma, Lobular / surgery. Female. Humans. Immunohistochemistry. Neoplasm Staging. Prognosis. Risk Assessment. Sampling Studies. Sensitivity and Specificity. Survival Rate

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  • (PMID = 15844179.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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71. Requena L, Santonja C, Stutz N, Kaddu S, Weenig RH, Kutzner H, Menzel T, Cerroni L: Pseudolymphomatous cutaneous angiosarcoma: a rare variant of cutaneous angiosarcoma readily mistaken for cutaneous lymphoma. Am J Dermatopathol; 2007 Aug;29(4):342-50
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  • [Title] Pseudolymphomatous cutaneous angiosarcoma: a rare variant of cutaneous angiosarcoma readily mistaken for cutaneous lymphoma.
  • Cutaneous angiosarcoma is probably the most malignant neoplasm involving the skin.
  • Three clinical variants of cutaneous angiosarcoma are recognized, including angiosarcoma of the scalp and face of elderly patients, angiosarcoma associated with chronic lymphedema, and postirradiation angiosarcoma.
  • Histopathologically, these three variants of angiosarcoma show similar features, which consist of poorly circumscribed, irregularly dilated, and anastomosing vascular channels lined by prominent endothelial cells that dissect through the dermis.
  • Cutaneous angiosarcoma with prominent lymphocytic infiltrate may be readily mistaken for cutaneous follicle center cell lymphoma or cutaneous pseudolymphoma.
  • [MeSH-major] Hemangiosarcoma / diagnosis. Lymphoma / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged. Breast Neoplasms / diagnosis. Diagnosis, Differential. Endothelial Cells / pathology. Endothelium, Vascular / pathology. Facial Neoplasms / diagnosis. Female. Humans. Lymphocytes / pathology. Lymphoma, Follicular / diagnosis. Male. Middle Aged. Neovascularization, Pathologic / pathology. Pseudolymphoma / diagnosis. Scalp / pathology. Skin Diseases / diagnosis

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  • (PMID = 17667166.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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72. Wang ZS, Zhan N, Xiong CL, Li H: Primary epithelioid angiosarcoma of the male breast: report of a case. Surg Today; 2007;37(9):782-6
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  • [Title] Primary epithelioid angiosarcoma of the male breast: report of a case.
  • We report a case of primary epithelioid angiosarcoma of the male breast.
  • Histopathological examination and immunohistochemical analysis confirmed a diagnosis of primary epithelioid angiosarcoma of the male breast, without axillary lymph node metastasis.
  • [MeSH-major] Breast Neoplasms, Male / pathology. Hemangiosarcoma / pathology. Neoplasms, Glandular and Epithelial / pathology

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  • (PMID = 17713733.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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73. Catena F, Santini D, Di Saverio S, Laneve A, Ansaloni L, Fogacci T, Gagliardi S, Gazzotti F, Guidi G, De Cataldis A, Taffurelli M: Skin angiosarcoma arising in an irradiated breast: case-report and literature review. Dermatol Surg; 2006 Mar;32(3):447-55
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Skin angiosarcoma arising in an irradiated breast: case-report and literature review.
  • BACKGROUND: Angiosarcoma (AS) is a rare, invasive malignancy originating from endothelial cells caused by many different clinical situations.
  • AS following radiotherapy for breast cancer after conservative surgery is a rare but well-known association.
  • OBJECTIVE: The aim of this article is to describe a case of AS after breast conserving surgery and to review the literature to date.
  • She presented with a one-month history or red papular skin eruptions on the operated breast.
  • The patients was subjected to surgical excision of the remaining breast including all AS lesions.
  • CONCLUSION: Post-radiotherapy AS is rare neoplasm, but it should be considered in the case of patients with red lesions after breast conserving surgery and adjuvant radiotherapy.
  • [MeSH-major] Breast Neoplasms / radiotherapy. Carcinoma, Ductal, Breast / radiotherapy. Hemangiosarcoma / pathology. Skin Neoplasms / pathology

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  • (PMID = 16640696.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 74
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74. Weed BR, Folpe AL: Cutaneous CD30-positive epithelioid angiosarcoma following breast-conserving therapy and irradiation: a potential diagnostic pitfall. Am J Dermatopathol; 2008 Aug;30(4):370-2
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  • [Title] Cutaneous CD30-positive epithelioid angiosarcoma following breast-conserving therapy and irradiation: a potential diagnostic pitfall.
  • A case of cutaneous epithelioid angiosarcoma with anomalous CD30 expression, occurring after breast-conserving surgery and adjuvant irradiation, is reported.
  • The differential diagnosis of CD30 epithelioid angiosarcoma is discussed.
  • [MeSH-major] Antigens, CD30 / biosynthesis. Hemangiosarcoma / metabolism. Neoplasms, Radiation-Induced / metabolism. Neoplasms, Second Primary / metabolism. Skin Neoplasms / metabolism
  • [MeSH-minor] Aged, 80 and over. Breast Neoplasms / radiotherapy. Breast Neoplasms / surgery. Carcinoma, Ductal, Breast / radiotherapy. Carcinoma, Ductal, Breast / surgery. Combined Modality Therapy. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Lymphoma, Large-Cell, Anaplastic / pathology. Radiotherapy, Adjuvant / adverse effects

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  • (PMID = 18645308.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD30
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75. West J, Liao SY, Cho D: Angiosarcoma after breast conservation: diagnostic pitfalls. Clin Breast Cancer; 2008 Feb;8(1):94-6
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  • [Title] Angiosarcoma after breast conservation: diagnostic pitfalls.
  • Although angiosarcomas are relatively rare, they are being reported with increasing frequency in patients who have previously undergone breast conserving therapy.
  • The initial clinical presentation of angiosarcomas after breast irradiation is often similar to the presentation of recurrent breast carcinomas.
  • In addition, the histologic and cytologic appearance of posttreatment angiosarcomas can be highly suggestive of recurrent breast carcinoma.
  • An accurate diagnosis is essential, because prognosis and treatment are different for each condition.
  • An early and accurate diagnosis is aided by a high index of suspicion by clinician and pathologist.
  • Herein, a case history is presented that underscores the pitfalls in attempting to achieve an accurate diagnosis.
  • [MeSH-major] Breast Neoplasms / surgery. Hemangiosarcoma / pathology. Neoplasms, Second Primary / pathology
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Mastectomy, Segmental. Middle Aged

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  • (PMID = 18501065.001).
  • [ISSN] 1526-8209
  • [Journal-full-title] Clinical breast cancer
  • [ISO-abbreviation] Clin. Breast Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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76. Nicolas MM, Nayar R, Yeldandi A, De Frias DV: Pulmonary metastasis of a postradiation breast epithelioid angiosarcoma mimicking adenocarcinoma. A case report. Acta Cytol; 2006 Nov-Dec;50(6):672-6
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  • [Title] Pulmonary metastasis of a postradiation breast epithelioid angiosarcoma mimicking adenocarcinoma. A case report.
  • BACKGROUND: Epithelioid angiosarcoma (EAS) is a mesenchymal neoplasm that may appear indistinguishable from carcinoma, melanoma and other tumors with epithelioid/epithelial differentiation.
  • The original breast tumor was typical of cribriform DCIS.
  • Review of the recurrent breast tumor (initially reported as DCIS) and a prior wedge resection of the lung nodules (reported as EAS) showed an epithelial-appearing tumor exhibiting an endothelial immunophenotype CONCLUSION: The cytologic features of EAS may resemble those of other neoplasms.
  • [MeSH-major] Adenocarcinoma / pathology. Breast Neoplasms / pathology. Carcinoma, Intraductal, Noninfiltrating / radiotherapy. Hemangiosarcoma / secondary. Lung Neoplasms / secondary. Neoplasms, Radiation-Induced / pathology. Radiotherapy / adverse effects
  • [MeSH-minor] Biopsy, Fine-Needle / methods. Diagnosis, Differential. Epithelioid Cells / pathology. Female. Humans. Middle Aged

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  • (PMID = 17152281.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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77. Brenn T, Fletcher CD: Radiation-associated cutaneous atypical vascular lesions and angiosarcoma: clinicopathologic analysis of 42 cases. Am J Surg Pathol; 2005 Aug;29(8):983-96
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Radiation-associated cutaneous atypical vascular lesions and angiosarcoma: clinicopathologic analysis of 42 cases.
  • Cutaneous angiosarcoma is a rare but well-recognized complication after radiation therapy.
  • A total of 42 cases diagnosed as either radiation-associated cutaneous vascular lesions or angiosarcoma were retrieved from departmental and consultation files from 1995 to 2003.
  • Reasons for radiation included breast carcinoma (35 cases) and a variety of other lesions (mainly malignant disease).
  • The time interval from radiation was significantly shorter for the development of AVL (median, 3.5 years) compared with cutaneous angiosarcoma (median, 6 years).
  • Histologic evaluation revealed 26 lesions meeting criteria for angiosarcoma, ranging from morphologically low-grade to high-grade; 16 cases were classified as AVLs.
  • All patients with systemic relapse had an initial diagnosis of angiosarcoma.
  • One patient with an AVL had a recurrence at the same site, 3 patients developed additional new lesions, and 1 patient developed multiple small papules on the chest wall, which progressed from an AVL to angiosarcoma.
  • [MeSH-major] Hemangiosarcoma / etiology. Hemangiosarcoma / pathology. Neoplasms, Radiation-Induced / pathology. Skin / blood supply. Skin / pathology. Skin Neoplasms / etiology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Breast Neoplasms / radiotherapy. Female. Follow-Up Studies. Humans. Middle Aged. Neoplasm Recurrence, Local. Neoplasms / radiotherapy. Time Factors

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  • (PMID = 16006792.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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78. Sanz C, Moreno F, Armas A, Casado A, Castillo MC: Groin angiosarcoma following radiotherapy for vulvar cancer. Gynecol Oncol; 2005 May;97(2):677-80
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  • [Title] Groin angiosarcoma following radiotherapy for vulvar cancer.
  • However, they represent 15% of radiotherapy-induced sarcomas, usually associated to the treatment for breast cancer, cervical cancer, and lymphomas.
  • CASE REPORT: We report the case of a 56-year-old patient who developed a soft tissue angiosarcoma in the right groin 25 years after receiving radiotherapy for vulvar cancer.
  • To our knowledge, this is the second case reported of a soft tissue angiosarcoma after radiotherapy for a vulvar cancer.
  • [MeSH-major] Hemangiosarcoma / etiology. Neoplasms, Radiation-Induced / etiology. Vulvar Neoplasms / radiotherapy

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  • (PMID = 15863181.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 14
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79. Brush M, Zhang J, Schuetze S, Sires B: Angiosarcoma metastatic to the orbit. Ophthal Plast Reconstr Surg; 2006 Jan-Feb;22(1):62-4
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  • [Title] Angiosarcoma metastatic to the orbit.
  • A 61-year-old woman developed metastatic angiosarcoma in her left orbit.
  • Diagnosis was confirmed with an incisional orbital biopsy and special markers.
  • Angiosarcoma was confirmed with histologic analysis.
  • Chemotherapy may be a useful palliative adjunct in the control of metastatic orbital angiosarcoma.
  • [MeSH-major] Breast Neoplasms / pathology. Hemangiosarcoma / secondary. Orbital Neoplasms / secondary
  • [MeSH-minor] Biopsy. Diagnosis, Differential. Fatal Outcome. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Middle Aged

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  • (PMID = 16418673.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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80. Soldić Z, Salopek D, Jazvić M, Radić J, Marić-Brozić J, Tomas D, Kirac P, Bolanca A, Kusić Z: Parenchymal post-irradiation angiosarcoma: a case report. Acta Clin Croat; 2009 Sep;48(4):433-7
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  • [Title] Parenchymal post-irradiation angiosarcoma: a case report.
  • Secondary angiosarcoma is an aggressive tumor that can develop in breast cancer patients treated with conserving therapy and radiotherapy.
  • A high grade of clinical suspicion is very important for early diagnosis.
  • A case of angiosarcoma involving breast parenchyma in a patient treated with quadrantectomy and radiotherapy for T1cN1Mx breast carcinoma is presented.
  • [MeSH-major] Breast Neoplasms / pathology. Hemangiosarcoma / pathology. Neoplasms, Radiation-Induced / pathology

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  • (PMID = 20405640.001).
  • [ISSN] 0353-9466
  • [Journal-full-title] Acta clinica Croatica
  • [ISO-abbreviation] Acta Clin Croat
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
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81. Tate G, Suzuki T, Mitsuya T: Mutation of the PTEN gene in a human hepatic angiosarcoma. Cancer Genet Cytogenet; 2007 Oct 15;178(2):160-2
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  • [Title] Mutation of the PTEN gene in a human hepatic angiosarcoma.
  • The PTEN protein inhibits angiogenesis, and somatic mutations of the PTEN gene are involved in canine hemangiosarcoma.
  • We screened for mutations of the PTEN gene in two patients with human hepatic angiosarcoma to determine whether PTEN is involved in the pathogenesis of human hepatic angiosarcoma.
  • In one patient, who suffered from breast cancer, pharyngeal cancer, and hepatic angiosarcoma, we found a single base substitution in exon 7 (640C>T) of the PTEN gene in both the hepatic angiosarcoma and normal tissues.
  • These findings indicate that analysis of PTEN gene mutations may be useful for characterization of the molecular event in hepatic angiosarcoma and cancer predisposition.
  • [MeSH-major] Hemangiosarcoma / genetics. Liver Neoplasms / genetics. Mutation. PTEN Phosphohydrolase / genetics
  • [MeSH-minor] Aged. Breast Neoplasms / genetics. Breast Neoplasms / pathology. Female. Genetic Predisposition to Disease. Humans. Immunohistochemistry. Male. Middle Aged. Pharyngeal Neoplasms / genetics. Pharyngeal Neoplasms / pathology. Polymerase Chain Reaction

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  • (PMID = 17954274.001).
  • [ISSN] 0165-4608
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.1.3.48 / PTEN protein, human; EC 3.1.3.67 / PTEN Phosphohydrolase
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82. Abraham JA, Hornicek FJ, Kaufman AM, Harmon DC, Springfield DS, Raskin KA, Mankin HJ, Kirsch DG, Rosenberg AE, Nielsen GP, Desphpande V, Suit HD, DeLaney TF, Yoon SS: Treatment and outcome of 82 patients with angiosarcoma. Ann Surg Oncol; 2007 Jun;14(6):1953-67
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Treatment and outcome of 82 patients with angiosarcoma.
  • METHODS: Patients with a diagnosis of angiosarcoma treated at our institution between 1980 and 2006 were analyzed for patient demographics, tumor characteristics, multimodality treatment, and outcomes.
  • Tumors were located throughout the body: 32 cutaneous, 22 deep soft tissues or organs, 10 radiation or lymphedema field, 8 bone, and 7 nonirradiated breast.
  • [MeSH-major] Hemangiosarcoma / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Bone Neoplasms / pathology. Bone Neoplasms / surgery. Breast Neoplasms / pathology. Breast Neoplasms / surgery. Chemotherapy, Adjuvant. Disease-Free Survival. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoadjuvant Therapy. Neoplasm Staging. Neoplasms, Radiation-Induced / pathology. Neoplasms, Radiation-Induced / surgery. Palliative Care. Radiotherapy, Adjuvant. Retrospective Studies. Skin Neoplasms / pathology. Skin Neoplasms / surgery. Soft Tissue Neoplasms / pathology. Soft Tissue Neoplasms / surgery. Survival Rate. Treatment Outcome

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  • (PMID = 17356953.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / 5K12CA87723-03
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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83. Gonne E, Collignon J, Kurth W, Thiry A, Henry F, Jerusalem G, Gennigens C: [Angiosarcoma in chronic lymphoedema: a case of Stewart-Treves syndrome]. Rev Med Liege; 2009 Jul-Aug;64(7-8):409-13
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  • [Title] [Angiosarcoma in chronic lymphoedema: a case of Stewart-Treves syndrome].
  • [Transliterated title] Angiosarcome sur lymphoedème chronique: un cas de syndrome de Stewart-Treves.
  • The Stewart-Treves Syndrome is defined as an angiosarcoma (very aggressive malignant tumor originating from endothelial cells) appearing in a specific clinical setting.
  • This tumor develops in patients suffering from chronic lymphedema of the upper limb following mastectomy and axillary lymph node dissection for breast cancer.
  • The diagnosis relies on medical history, clinical examination and a histological assesment (biopsy or resection).
  • [MeSH-major] Arm / pathology. Lymphangiosarcoma / diagnosis. Lymphedema / complications. Neoplasms, Second Primary / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Breast Neoplasms / pathology. Breast Neoplasms / surgery. Carcinoma / pathology. Carcinoma / surgery. Female. Humans. Lymph Node Excision / adverse effects. Mastectomy / methods. Middle Aged. Prognosis. Syndrome

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  • (PMID = 19777923.001).
  • [ISSN] 0370-629X
  • [Journal-full-title] Revue médicale de Liège
  • [ISO-abbreviation] Rev Med Liege
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Belgium
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84. Mobini N: Cutaneous epithelioid angiosarcoma: a neoplasm with potential pitfalls in diagnosis. J Cutan Pathol; 2009 Mar;36(3):362-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cutaneous epithelioid angiosarcoma: a neoplasm with potential pitfalls in diagnosis.
  • Angiosarcoma (AS) is a rare neoplasm.
  • This subset can histologically mimic non-vascular neoplasms and impose serious challenges in reaching the correct diagnosis.
  • We present five patients with cutaneous epithelioid angiosarcoma (EAS); in none, the clinical diagnosis included a vascular lesion.
  • Three patients had history of breast conservation surgery with/without radiation therapy.
  • Only after performing immunohistochemical studies that included vascular markers, a definitive diagnosis was possible.
  • Cutaneous EAS is a rare variant of cutaneous AS that can mimic a variety of more common, non-vascular neoplasms, creating a major pitfall in the diagnosis.
  • A careful and thorough histopathological examination and a high index of suspicion, along with appropriate immunohistochemical evaluation, can help reach a correct diagnosis and provide optimal patient care.
  • [MeSH-major] Hemangiosarcoma / pathology. Melanoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. Female. Humans. Male. Middle Aged

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  • (PMID = 19220634.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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85. Ricchetti T, Paci M, Cavazza A, Ferrari G, Annessi V, De Franco S, Sgarbi G: A case of metastatic epithelioid angiosarcoma in the lamina propria of a sigmoid tubulovillous adenoma. Tumori; 2005 Mar-Apr;91(2):210-2

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  • [Title] A case of metastatic epithelioid angiosarcoma in the lamina propria of a sigmoid tubulovillous adenoma.
  • Epithelioid angiosarcoma is an extremely rare tumor.
  • It is generally a secondary tumor and the preferred sites of such metastases are the heart, pericardium, lung, breast, liver, spleen, bone, and brain.
  • We report a case of epithelioid angiosarcoma with multiple bilateral lung infiltration, bone metastasis, and metastasis of the lamina propria of a tubulovillous adenoma of the colon.
  • [MeSH-major] Adenoma / pathology. Basement Membrane / pathology. Epithelioid Cells / pathology. Hemangiosarcoma / pathology. Hemangiosarcoma / secretion. Sigmoid Neoplasms / pathology

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  • (PMID = 15948556.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antigens, CD31
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86. Patton KT, Deyrup AT, Weiss SW: Atypical vascular lesions after surgery and radiation of the breast: a clinicopathologic study of 32 cases analyzing histologic heterogeneity and association with angiosarcoma. Am J Surg Pathol; 2008 Jun;32(6):943-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atypical vascular lesions after surgery and radiation of the breast: a clinicopathologic study of 32 cases analyzing histologic heterogeneity and association with angiosarcoma.
  • We report the clinicopathologic study of 32 cases of atypical vascular lesions (AVLs) after surgery and radiation of the breast, which were referred to us in consultation over a 17-year period.
  • Of the 21 patients, 17 are alive without disease, 1 is alive with disease, 1 died of breast carcinoma, 1 died of unknown causes, and 1 showed progressive histologic changes in the AVLs over a period of 5 years resulting in a well-differentiated angiosarcoma.
  • One patient underwent a mastectomy that revealed extensive residual AVL and the second developed a high-grade angiosarcoma after 14 months.
  • There seems to be an association of AVL with angiosarcoma that differs depending on the histologic features, with the VT AVLs having the higher risk.
  • In the 2 patients who developed angiosarcoma, morphologic evidence suggested AVLs to be a precursor rather than simply a risk factor.
  • [MeSH-major] Breast Neoplasms / pathology. Hemangiosarcoma / pathology. Neoplasms, Radiation-Induced / pathology

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  • (PMID = 18551753.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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87. Di Tommaso L, Rosai J: The capillary lobule: a deceptively benign feature of post-radiation angiosarcoma of the skin: report of three cases. Am J Dermatopathol; 2005 Aug;27(4):301-5
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  • [Title] The capillary lobule: a deceptively benign feature of post-radiation angiosarcoma of the skin: report of three cases.
  • Three cases are presented of a proliferative vascular lesion of the skin developing in the chest wall of women who had received radiation therapy for breast carcinoma.
  • All 3 lesions were characterized microscopically by the presence of the so-called capillary lobule, a formation generally regarded as a sign of benignancy but that in this setting proved to be a forerunner or indicator of angiosarcoma (malignant hemangioendothelioma).
  • Therefore, the detection of capillary lobules in irradiated skin ought to be regarded with great suspicion, and other morphologic signs suggestive of angiosarcoma should be sought in the specimen.
  • [MeSH-major] Hemangiosarcoma / pathology. Neoplasms, Radiation-Induced / pathology. Neoplasms, Second Primary / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Breast Neoplasms / therapy. Female. Humans

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  • [CommentIn] Am J Dermatopathol. 2006 Aug;28(4):376 [16871048.001]
  • (PMID = 16121049.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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88. Mignogna C, Simonetti S, Galloro G, Magno L, De Cecio R, Insabato L: Duodenal epithelioid angiosarcoma: immunohistochemical and clinical findings. A case report. Tumori; 2007 Nov-Dec;93(6):619-21
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  • [Title] Duodenal epithelioid angiosarcoma: immunohistochemical and clinical findings. A case report.
  • Angiosarcomas mainly involve skin and soft tissue and rarely occur in breast, liver, bone, and spleen.
  • A duodenal reddish polypoid lesion was found, which on microscopic examination turned out to be an epithelioid angiosarcoma.
  • The immunohistochemical features of the lesion supported this diagnosis.
  • The patient died eight months after the diagnosis.
  • Epithelioid angiosarcoma is an aggressive variant of angiosarcoma and must be considered in the differential diagnosis of gastrointestinal tumors.
  • [MeSH-major] Duodenal Neoplasms / pathology. Hemangioendothelioma, Epithelioid / pathology. Hemangiosarcoma / pathology

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  • (PMID = 18338501.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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89. Schindera ST, Streit M, Kaelin U, Stauffer E, Steinbach L, Anderson SE: Stewart-Treves syndrome: MR imaging of a postmastectomy upper-limb chronic lymphedema with angiosarcoma. Skeletal Radiol; 2005 Mar;34(3):156-60
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  • [Title] Stewart-Treves syndrome: MR imaging of a postmastectomy upper-limb chronic lymphedema with angiosarcoma.
  • The rare occurrence of angiosarcoma in postmastectomy upper-limb lymphedema with magnetic resonance (MR) imaging is discussed.
  • Unfamiliarity with this aggressive vascular tumor and its harmless appearance often leads to delayed diagnosis.
  • Angiosarcoma complicating chronic lymphedema may be low in signal intensity on T2-weighting and short tau inversion recovery (STIR) imaging reflecting the densely cellular, fibrous stroma, and sparsely vascularized tumor histology.
  • Awareness of angiosarcoma and its MR imaging appearance in patients with chronic lymphedema may be a key to early diagnosis or allow at least inclusion in the differential diagnosis.
  • [MeSH-major] Lymphangiosarcoma / diagnosis. Lymphedema / complications. Magnetic Resonance Imaging / methods. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged, 80 and over. Arm. Breast Neoplasms / radiotherapy. Breast Neoplasms / surgery. Chronic Disease. Diagnosis, Differential. Female. Humans. Mastectomy / adverse effects. Syndrome


90. Aguiar Bujanda D, Camacho Galán R, Bastida Iñarrea J, Aguiar Morales J, Conde Martel A, Rivero Suárez P, de Armas Diaz F, Bohn Sarmiento U, Cabrera Suárez MA: Angiosarcoma of the abdominal wall after dermolipectomy in a morbidly obese man. A rare form of presentation of Stewart-Treves syndrome. Eur J Dermatol; 2006 May-Jun;16(3):290-2
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  • [Title] Angiosarcoma of the abdominal wall after dermolipectomy in a morbidly obese man. A rare form of presentation of Stewart-Treves syndrome.
  • Angiosarcoma is a rare malignant tumor, with a predilection for skin in the head and neck region, although it has been described in many other locations.
  • Its association with chronic lymphedema is well known, mainly in the setting of postmastectomy lymphedema of the arm in breast cancer patients (termed Stewart-Treves syndrome).
  • However, angiosarcoma can appear in lower limbs with chronic lymphedema and rarely in other locations such as the abdominal wall.
  • Herein, we present a unique case of angiosarcoma developing in the abdominal wall of a morbidly obese patient after extensive dermolipectomy.
  • [MeSH-major] Abdominal Wall / pathology. Dermatologic Surgical Procedures. Hemangiosarcoma / diagnosis. Lipectomy / methods. Obesity, Morbid / complications

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  • (PMID = 16709497.001).
  • [ISSN] 1167-1122
  • [Journal-full-title] European journal of dermatology : EJD
  • [ISO-abbreviation] Eur J Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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91. Virtanen A, Pukkala E, Auvinen A: Angiosarcoma after radiotherapy: a cohort study of 332,163 Finnish cancer patients. Br J Cancer; 2007 Jul 2;97(1):115-7
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  • [Title] Angiosarcoma after radiotherapy: a cohort study of 332,163 Finnish cancer patients.
  • We evaluated the risk of angiosarcoma after radiotherapy among all patients with cancers of breast, cervix uteri, corpus uteri, lung, ovary, prostate, or rectum, and lymphoma diagnosed in Finland during 1953-2003, identified from the Finnish Cancer Registry.
  • In the follow-up of 1.8 million person-years at risk, 19 angiosarcomas developed, all after breast and gynaecological cancer.
  • Although an increased risk of angiosarcoma among cancer patients is evident, especially with breast and gynaecological cancer, the excess does not appear to be strongly related to radiotherapy.
  • [MeSH-major] Hemangiosarcoma / epidemiology. Neoplasms / radiotherapy. Neoplasms, Radiation-Induced / epidemiology. Neoplasms, Second Primary / epidemiology. Radiotherapy / adverse effects

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  • (PMID = 17519906.001).
  • [ISSN] 0007-0920
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2359658
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92. Asmane I, Litique V, Heymann S, Marcellin L, Métivier AC, Duclos B, Bergerat JP, Kurtz JE: Adriamycin, cisplatin, ifosfamide and paclitaxel combination as front-line chemotherapy for locally advanced and metastatic angiosarcoma. Analysis of three case reports and review of the literature. Anticancer Res; 2008 Sep-Oct;28(5B):3041-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adriamycin, cisplatin, ifosfamide and paclitaxel combination as front-line chemotherapy for locally advanced and metastatic angiosarcoma. Analysis of three case reports and review of the literature.
  • Angiosarcoma represents 1 to 2% of soft tissue tumors.
  • It originates from endothelial cells of small blood vessels and may affect a variety of organs, including the retroperitoneum, skeletal muscle, subcutis, liver, heart and breast.
  • The outcome of angiosarcoma is poor for those patients in whom aggressive surgery cannot be considered.
  • We report three cases of angiosarcoma in which first-line chemotherapy with adriamycin 40 mg/m2 day 1, ifosfamide 3 g/m2 day 1-2, cisplatin 35 mg/m2 day 1-2 and paclitaxel 175 mg/m2 day 3 led to clinically meaningful responses.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bone Neoplasms / drug therapy. Breast Neoplasms / drug therapy. Hemangiosarcoma / drug therapy. Soft Tissue Neoplasms / drug therapy

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  • (PMID = 19031953.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 80168379AG / Doxorubicin; P88XT4IS4D / Paclitaxel; Q20Q21Q62J / Cisplatin; UM20QQM95Y / Ifosfamide
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93. Gagnon PJ, Galderisi C, Page BR, Holland JM: Angiosarcoma developing after curative induction chemotherapy and radiotherapy for locally advanced squamous cell carcinoma of the larynx. Head Neck; 2009 Jun;31(6):829-32
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  • [Title] Angiosarcoma developing after curative induction chemotherapy and radiotherapy for locally advanced squamous cell carcinoma of the larynx.
  • BACKGROUND: Angiosarcoma arising after radiation is described in breast cancer but occurs elsewhere.
  • Here, we present an angiosarcoma of the neck occurring after curative chemoradiation.
  • METHODS: This is a case of angiosarcoma developing 5 years after curative therapy for T3N0 squamous cell carcinoma of the supraglottic larynx.
  • Examination showed a 7-cm mass and biopsy revealed angiosarcoma.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / adverse effects. Carcinoma, Squamous Cell / therapy. Hemangiosarcoma / etiology. Laryngeal Neoplasms / therapy. Radiotherapy, High-Energy / adverse effects. Skin Neoplasms / etiology

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  • [Copyright] (c) 2008 Wiley Periodicals, Inc.
  • (PMID = 18853452.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] P88XT4IS4D / Paclitaxel
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94. Nagano T, Yamada Y, Ikeda T, Kanki H, Kamo T, Nishigori C: Docetaxel: a therapeutic option in the treatment of cutaneous angiosarcoma: report of 9 patients. Cancer; 2007 Aug 1;110(3):648-51
Hazardous Substances Data Bank. DOCETAXEL .

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  • [Title] Docetaxel: a therapeutic option in the treatment of cutaneous angiosarcoma: report of 9 patients.
  • BACKGROUND: Effective treatment options are limited for patients with cutaneous angiosarcoma (AS).
  • Docetaxel, a member of the taxane family of drugs, reportedly has been effective in the treatment of lung, head and neck, and breast cancers.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Hemangiosarcoma / drug therapy. Skin Neoplasms / drug therapy. Taxoids / therapeutic use

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  • [Copyright] (c) 2007 American Cancer Society.
  • (PMID = 17582627.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Taxoids; 15H5577CQD / docetaxel
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95. Bacchi CE, Silva TR, Zambrano E, Plaza J, Suster S, Luzar B, Lamovec J, Pizzolitto S, Falconieri G: Epithelioid angiosarcoma of the skin: a study of 18 cases with emphasis on its clinicopathologic spectrum and unusual morphologic features. Am J Surg Pathol; 2010 Sep;34(9):1334-43
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epithelioid angiosarcoma of the skin: a study of 18 cases with emphasis on its clinicopathologic spectrum and unusual morphologic features.
  • We report 18 cases of cutaneous angiosarcoma with predominant or exclusive epithelioid morphology.
  • In elderly patients scalp or facial lesions and cutaneous lesions arising within irradiated breast skin predominated.
  • Our data show that epithelioid cutaneous angiosarcoma may have a broad morphological spectrum, raising interpretive challenges on microscopy.
  • [MeSH-major] Epithelioid Cells / pathology. Hemangiosarcoma / pathology. Skin Neoplasms / pathology

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  • (PMID = 20697249.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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96. Kajo K, Lúcan J, Macháleková K, Beratsová Z: [Cutaneous angiosarcoma following conservative surgery and radiotherapy for breast carcinoma. A case report]. Cesk Patol; 2007 Apr;43(2):59-63
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  • [Title] [Cutaneous angiosarcoma following conservative surgery and radiotherapy for breast carcinoma. A case report].
  • Breast angiosarcomas (AS) are very rare neoplasms, which can be divided into primary (or sporadic), and secondary AS, the latter arising either on the base of lymphoedema after mastectomy (so called AS with Stewart-Treves syndrome- ASSTS), or skin AS after breast conservation surgery with subsequent radiotherapy for breast cancer (KPRAS).
  • The authors present a case of a 55-year-old female patient with a 17mm tumour in nipple region, developing 8 years after primary diagnosis of tubulolobular carcinoma of the breast which was treated by breast conservation surgery and radiotherapy.
  • The authors analyse the basic clinical and morphological features of KPRAS, which distinguish it from other forms of AS, e.g. occurrence in older age, shorter period of latency after radiation therapy when compared to ASSTS, absence of lymphoedema, and rare involvement of the breast tissue.
  • [MeSH-major] Breast Neoplasms / radiotherapy. Breast Neoplasms / surgery. Hemangiosarcoma / etiology. Neoplasms, Second Primary / pathology. Skin Neoplasms / etiology
  • [MeSH-minor] Breast. Female. Humans. Mastectomy, Segmental. Middle Aged. Neoplasms, Radiation-Induced / pathology

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  • (PMID = 17623978.001).
  • [ISSN] 1210-7875
  • [Journal-full-title] Československá patologie
  • [ISO-abbreviation] Cesk Patol
  • [Language] slo
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Czech Republic
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97. Wierzbicka-Hainaut E, Guillet G: [Stewart-Treves syndrome (angiosarcoma on lyphoedema): A rare complication of lymphoedema]. Presse Med; 2010 Dec;39(12):1305-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Stewart-Treves syndrome (angiosarcoma on lyphoedema): A rare complication of lymphoedema].
  • [Transliterated title] Syndrome de Stewart-Treves (angiosarcome sur lymphœdème) : complication rare du lymphœdème.
  • Stewart-Treves syndrome (SST) or former lymphangiosarcoma is a rare complication of chronic lymphoedema mainly related to the breast cancer (90% of cases).
  • [MeSH-major] Lymphedema / complications. Lymphedema / diagnosis
  • [MeSH-minor] Breast Neoplasms / mortality. Breast Neoplasms / surgery. Chronic Disease. Combined Modality Therapy. Female. Hemangiosarcoma / diagnosis. Hemangiosarcoma / etiology. Hemangiosarcoma / mortality. Hemangiosarcoma / therapy. Humans. Lymphangiosarcoma / diagnosis. Lymphangiosarcoma / etiology. Lymphangiosarcoma / mortality. Lymphangiosarcoma / therapy. Mastectomy, Radical. Postoperative Complications / diagnosis. Postoperative Complications / etiology. Postoperative Complications / mortality. Prognosis. Survival Rate

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  • [Copyright] Copyright © 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20970956.001).
  • [ISSN] 2213-0276
  • [Journal-full-title] Presse medicale (Paris, France : 1983)
  • [ISO-abbreviation] Presse Med
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Chemical-registry-number] Stewart Treves syndrome
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98. AbdullGaffar B: Pseudoangiomatous stromal hyperplasia of the breast. Arch Pathol Lab Med; 2009 Aug;133(8):1335-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pseudoangiomatous stromal hyperplasia of the breast.
  • Pseudoangiomatous stromal hyperplasia is a relatively common lesion of the breast.
  • Histologically, it can be confused with low-grade angiosarcoma.
  • [MeSH-major] Breast Diseases / pathology
  • [MeSH-minor] Antineoplastic Agents, Hormonal / therapeutic use. Biomarkers / metabolism. Diagnosis, Differential. Female. Fibroblasts / ultrastructure. Hemangiosarcoma / diagnosis. Humans. Hyperplasia / pathology. Male. Mammography. Mastectomy. Prognosis. Stromal Cells / ultrastructure. Tamoxifen / therapeutic use

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  • (PMID = 19653734.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Hormonal; 0 / Biomarkers; 094ZI81Y45 / Tamoxifen
  • [Number-of-references] 23
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99. Tahir M, Hendry P, Baird L, Qureshi NA, Ritchie D, Whitford P: Radiation induced angiosarcoma a sequela of radiotherapy for breast cancer following conservative surgery. Int Semin Surg Oncol; 2006;3:26

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Radiation induced angiosarcoma a sequela of radiotherapy for breast cancer following conservative surgery.
  • Radiation induced angiosarcomas (RIA) can affect breast cancer patients who had radiotherapy following conservative breast surgery.
  • They are very rare tumors and often their diagnosis is delayed due to their benign appearance and difficulty in differentiation from radiation induced skin changes.

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  • (PMID = 16965616.001).
  • [ISSN] 1477-7800
  • [Journal-full-title] International seminars in surgical oncology : ISSO
  • [ISO-abbreviation] Int Semin Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1570350
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100. Crosby MA, Chike-Obi CJ, Baumann DP, Sacks JM, Villa MT, Garvey PB, Selber JC, Feig BW: Reconstructive outcomes in patients with sarcoma of the breast. Plast Reconstr Surg; 2010 Dec;126(6):1805-14
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Reconstructive outcomes in patients with sarcoma of the breast.
  • BACKGROUND: Primary soft-tissue sarcomas account for less than 1 percent of all breast malignancies.
  • The purpose of this study was to examine reconstruction techniques and outcomes in a cohort of patients with breast sarcoma to elucidate the optimal type and timing of reconstruction.
  • METHODS: The authors conducted a retrospective review of all patients diagnosed and treated for soft-tissue breast sarcomas between July 1, 1988, and December 9, 2009, at a tertiary cancer center.
  • RESULTS: Twenty-three breast sarcoma patients underwent 24 reconstructions.
  • The mean age at diagnosis was 42 years (range, 17 to 78 years).
  • The most common histologic finding was angiosarcoma; six of the 11 angiosarcomas developed following irradiation for either breast carcinoma or lymphoma.
  • CONCLUSIONS: Soft-tissue breast sarcomas are uncommon and demand aggressive, multimodal treatment and well-planned reconstruction.
  • [MeSH-major] Breast Implantation / methods. Breast Neoplasms / surgery. Mammaplasty / methods. Postoperative Complications / etiology. Sarcoma / surgery. Surgical Flaps / blood supply
  • [MeSH-minor] Adolescent. Adult. Aged. Combined Modality Therapy. Disease-Free Survival. Female. Hemangiosarcoma / mortality. Hemangiosarcoma / surgery. Humans. Middle Aged. Neoplasm Recurrence, Local / mortality. Neoplasm Recurrence, Local / surgery. Neoplasms, Radiation-Induced / mortality. Neoplasms, Radiation-Induced / surgery. Neoplasms, Second Primary / mortality. Neoplasms, Second Primary / surgery. Reoperation. Retrospective Studies. Treatment Outcome. Young Adult






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