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1. Kinderyte R, Alisauskaite L, Juodzbaliene EB, Juozaityte E: [Angiosarcoma of the breast: a case report and literature review]. Medicina (Kaunas); 2006;42(7):580-5
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  • [Title] [Angiosarcoma of the breast: a case report and literature review].
  • [Transliterated title] Krūties angiosarkoma.
  • Sarcoma of the breast is a rare tumor (makes up 0.5 to 1% of all malignant breast tumors).
  • In literature, only isolated cases of primary angiosarcoma of the breast were described.
  • Secondary angiosarcomas are more frequently diagnosed in women and mostly in patients who underwent breast-conserving surgery and were treated by radiotherapy.
  • In this article a very rare case of angiosarcoma of the breast is presented.
  • After surgery the diagnosis of hematoma was made.
  • After review of histopathology slides the likely diagnosis of angiosarcoma of the breast was made.
  • A patient from the time of diagnosis survived for 8 months.
  • The mean survival of patients with angiosarcoma of the breast, described in literature, ranges from 13 to 22 months, and the treatment in this case most likely could not have an effect on survival of the patient.
  • [MeSH-major] Breast Neoplasms. Hemangiosarcoma
  • [MeSH-minor] Adult. Breast / pathology. Diagnosis, Differential. Female. Humans. Lung Neoplasms / radiography. Lung Neoplasms / secondary. Lymphatic Metastasis / diagnosis. Mastectomy, Simple. Prognosis. Radiography, Thoracic. Time Factors

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  • (PMID = 16861841.001).
  • [ISSN] 1648-9144
  • [Journal-full-title] Medicina (Kaunas, Lithuania)
  • [ISO-abbreviation] Medicina (Kaunas)
  • [Language] lit
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Lithuania
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2. Mankey CC, McHugh JB, Thomas DG, Lucas DR: Can lymphangiosarcoma be resurrected? A clinicopathological and immunohistochemical study of lymphatic differentiation in 49 angiosarcomas. Histopathology; 2010 Feb;56(3):364-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Can lymphangiosarcoma be resurrected? A clinicopathological and immunohistochemical study of lymphatic differentiation in 49 angiosarcomas.
  • AIMS: The term lymphangiosarcoma has largely been abandoned in the current classification of endothelial neoplasms.
  • Recently, a number of lymphatic-associated antibodies have been developed for immunohistochemistry, which frequently stain angiosarcomas, implying lymphatic or mixed lymphatic and blood vascular differentiation is common.
  • METHODS AND RESULTS: Forty-nine angiosarcomas in tissue microarrays were analysed with D2-40 and antibodies to Prox-1 and vascular endothelial growth factor receptor (VEGFR)-3.
  • CONCLUSIONS: Lymphatic differentiation is common in angiosarcoma, certain subsets show greater lymphatic differentiation than others, and lymphangiosarcoma may be defined pathologically, rather than clinically.
  • [MeSH-major] Antibodies, Monoclonal. Endothelium, Lymphatic / pathology. Hemangiosarcoma / pathology. Lymphangiosarcoma / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Antibodies, Monoclonal, Murine-Derived. Cell Differentiation. Female. Homeodomain Proteins / metabolism. Humans. Immunohistochemistry. Male. Middle Aged. Receptors, Vascular Endothelial Growth Factor / metabolism. Tissue Array Analysis. Tumor Suppressor Proteins / metabolism

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  • (PMID = 20459536.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Homeodomain Proteins; 0 / Tumor Suppressor Proteins; 0 / monoclonal antibody D2-40; 0 / prospero-related homeobox 1 protein; EC 2.7.10.1 / Receptors, Vascular Endothelial Growth Factor
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3. Iwamoto K, Suzuki S, Kurata A, Sato K, Niki J, Miyazaki T, Utsuki S, Oka H, Fujii K, Kan S, Masuzawa M: Efficacy of selective transarterial chemotherapy using a port systemfor angiosarcomas of the face and scalp. Interv Neuroradiol; 2008 Jun 30;14(2):137-41

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  • [Title] Efficacy of selective transarterial chemotherapy using a port systemfor angiosarcomas of the face and scalp.
  • SUMMARY: Angiosarcoma is a rare, highly malignant tumor with a poor clinical outcome.
  • From January 2004 to September 2005, we advocated transarterial chemotherapy using a port system for four patients with angiosarcomas of the face and scalp.
  • Transarterial infusion chemotherapy using such a port system may be particularly effective for angiosarcoma in the early stages because small lesions with limited invasion mean a small territory of blood supply to be covered, and useful life was possible because the port system embedded in subcutaneous tissue allows treatment in an out-patient clinic.

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  • (PMID = 20557754.001).
  • [ISSN] 1591-0199
  • [Journal-full-title] Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences
  • [ISO-abbreviation] Interv Neuroradiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3313716
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4. Aviles-Salas A, Luévano-González A: [Primary angiosarcoma of the spleen: report of one case]. Rev Med Chil; 2007 Sep;135(9):1178-81

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  • [Title] [Primary angiosarcoma of the spleen: report of one case].
  • [Transliterated title] Angiosarcoma primario del bazo: Caso clínico.
  • Primary angiosarcoma of the spleen is rare and almost always fatal.
  • It has an aggressive behavior and frequently presents with hematological abnormalities or metastatic disease.
  • He was subjected to a splenectomy and the biopsy disclosed an angiosarcoma of the spleen.
  • [MeSH-major] Hemangiosarcoma / pathology. Splenic Neoplasms / pathology

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  • (PMID = 18064374.001).
  • [ISSN] 0034-9887
  • [Journal-full-title] Revista médica de Chile
  • [ISO-abbreviation] Rev Med Chil
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Chile
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5. Peramiquel L, Barnadas MA, Sancho J, Curell R, Alonso MC, Fuentes MJ, Pernas S, Gómez A, Alomar A: [Angiosarcoma in an irradiated breast: a case description]. Actas Dermosifiliogr; 2005 Nov;96(9):602-6
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  • [Title] [Angiosarcoma in an irradiated breast: a case description].
  • [Transliterated title] Angiosarcoma en mama irradiada: descripción de un caso.
  • Post-radiotherapy cutaneous angiosarcomas have been described in different locations, including the breast.
  • We present a case of cutaneous angiosarcoma of the breast, diagnosed 6 years after a carcinoma of the breast had been treated with radiation.
  • Considering the patient's symptoms, history and the changes observed via mammography, it was decided to completely excise the lesion followed by a simple mastectomy, with the diagnosis of angiosarcoma being confirmed.
  • The patient was later treated with paclitaxel, and the disease was apparently controlled.
  • Despite this fact, two years and one month later, the angiosarcoma recurred on the internal area of the mastectomy scar.
  • This complication usually appears 5-10 years after treatment with radiotherapy, so angiosarcoma should be ruled out if any angiomatous lesions later appear on skin that had been irradiated.
  • [MeSH-major] Breast Neoplasms / etiology. Breast Neoplasms / radiotherapy. Carcinoma, Ductal, Breast / radiotherapy. Hemangiosarcoma / etiology. Neoplasms, Radiation-Induced / etiology. Skin Neoplasms / etiology

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  • (PMID = 16476306.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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6. Vogt T: [Angiosarcoma]. Hautarzt; 2008 Mar;59(3):237-48; quiz 249-50
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  • [Title] [Angiosarcoma].
  • [Transliterated title] Angiosarkom.
  • Angiosarcomas are rare tumors accounting for 1-2% of all soft tissue sarcomas.
  • Angiosarcoma favors superficial soft tissues and skin (60%) with a clear predilection for the head and neck region.
  • The average age of the patients presenting with cutaneous angiosarcomas is around 70 years with a peak incidence in the 8th decade.
  • Secondary angiosarcoma after tissue-conserving radiation therapy for carcinoma of the breast represents an increasing problem, both the differentiation between atypical vascular lesions and true aggressive angiosarcoma and the therapy are challenging.
  • The prognosis for angiosarcoma patients is gloomy despite all therapeutic efforts.
  • [MeSH-major] Hemangiosarcoma / diagnosis. Hemangiosarcoma / therapy. Skin Neoplasms / diagnosis. Skin Neoplasms / therapy

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  • (PMID = 18273583.001).
  • [ISSN] 1432-1173
  • [Journal-full-title] Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
  • [ISO-abbreviation] Hautarzt
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 27
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7. Yang WT, Hennessy BT, Dryden MJ, Valero V, Hunt KK, Krishnamurthy S: Mammary angiosarcomas: imaging findings in 24 patients. Radiology; 2007 Mar;242(3):725-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mammary angiosarcomas: imaging findings in 24 patients.
  • PURPOSE: To retrospectively evaluate the clinical, imaging, and pathologic findings of mammary angiosarcomas in 24 patients.
  • Twenty-four patients with records in the surgical pathology database who had a diagnosis of mammary angiosarcoma (n = 26) and who underwent preoperative imaging with mammography, ultrasonography (US), or magnetic resonance (MR) imaging were included.
  • Mean and median ages at time of diagnosis were 40 and 38 years, respectively (range, 15-77 years).
  • Total length of follow-up (in months) was determined by the interval from the time of diagnosis to the time of last follow-up.
  • Information on overall and disease-free survival was also obtained.
  • RESULTS: Mean tumor size at time of diagnosis was 5.9 cm (range, 1-12 cm).
  • Mammograms of 16 tumors showed a noncalcified mass in eight, focal asymmetry in five, and no abnormality in three.
  • Dynamic contrast material-enhanced MR imaging of nine tumors showed large, lobular, and intensely and heterogeneously enhancing masses with rapid enhancement and the washout characteristics of a malignant lesion.
  • CONCLUSION: A mass that shows homogeneous or heterogeneous hyperechogenicity at US (with associated architectural distortion) and has a hypervascular, hemorrhagic, and heterogeneous appearance and typical malignant enhancement characteristics at MR imaging should alert the radiologist to a possible diagnosis of angiosarcoma.
  • [MeSH-major] Breast Neoplasms / diagnosis. Hemangiosarcoma / diagnosis. Magnetic Resonance Imaging / methods. Ultrasonography, Mammary / methods

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  • (PMID = 17325063.001).
  • [ISSN] 0033-8419
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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8. Vorburger SA, Xing Y, Hunt KK, Lakin GE, Benjamin RS, Feig BW, Pisters PW, Ballo MT, Chen L, Trent J 3rd, Burgess M, Patel S, Pollock RE, Cormier JN: Angiosarcoma of the breast. Cancer; 2005 Dec 15;104(12):2682-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma of the breast.
  • BACKGROUND: Angiosarcoma of the breast is a rare entity.
  • METHODS: Clinical and pathologic factors were analyzed in all patients with angiosarcoma of the breast treated between 1990 and 2003.
  • Overall survival (OS) and disease-free survival (DFS) were estimated using the methods of Kaplan and Meier.
  • RESULTS: Fifty-five women with angiosarcoma of the breast were identified.
  • For the 32 patients with primary angiosarcoma of the breast 5-year OS was 59%.
  • These patients with radiation therapy-associated angiosarcoma were on average 30 years older and less likely to present with distant metastatic disease than patients presenting with radiation-naive angiosarcoma of the breast.
  • Although radiation-naive patients appeared to have had better early DFS and OS, the Kaplan-Meier curves were not statistically different between patients with radiation therapy-associated disease and radiation therapy-naive patients.
  • CONCLUSIONS: In this series of 55 patients with angiosarcoma of the breast, radiation therapy-naive angiosarcomas occurred in younger patients, but they behaved similarly to radiation therapy-associated angiosarcomas.
  • [MeSH-major] Breast Neoplasms / mortality. Breast Neoplasms / therapy. Hemangiosarcoma / mortality. Hemangiosarcoma / therapy. Mastectomy / methods
  • [MeSH-minor] Adult. Biopsy, Needle. Chemotherapy, Adjuvant. Cohort Studies. Combined Modality Therapy. Confidence Intervals. Disease-Free Survival. Female. Humans. Immunohistochemistry. Middle Aged. Neoplasm Staging. Probability. Prognosis. Proportional Hazards Models. Radiotherapy, Adjuvant. Retrospective Studies. Risk Assessment. Survival Analysis

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  • [Copyright] Copyright 2005 American Cancer Society.
  • (PMID = 16288486.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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9. Pfeiffer DF, Bode-Lesniewska B: Fine needle aspiration biopsy diagnosis of angiosarcoma after breast-conserving therapy for carcinoma supported by use of a cell block and immunohistochemistry. Acta Cytol; 2006 Sep-Oct;50(5):553-6
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  • [Title] Fine needle aspiration biopsy diagnosis of angiosarcoma after breast-conserving therapy for carcinoma supported by use of a cell block and immunohistochemistry.
  • BACKGROUND: Angiosarcoma is a rare malignant soft tissue tumor occurring at various sites as either a primary or secondary event.
  • Primary angiosarcoma of the breast is an unusual tumor, counting for 1 in 1700-2,000 primary malignant tumors of this organ.
  • An increasing number of secondary angiosarcomas involving skin and breast.
  • CASE: Angiosarcoma arose 6 years after breast-conserving therapy for invasive carcinoma in a 69-year-old woman.
  • Fine needle aspiration of several small, reddish, intradermal nodules over the treated area revealed malignant cells with an endothelial immunophenotype in the cel block, yielding the diagnosis of angiosarcoma, subsequently confired in a mastectomy speciman.
  • CONCLUSION: Fine needle aspiration, supported by ancillary techniques, such as cell block and immunohistochemistry, allows the cytologic diagnosis of an angiosarcoma and differentiates it from a carcinoma recurrence.
  • [MeSH-major] Breast / pathology. Breast Neoplasms / diagnosis. Carcinoma, Ductal, Breast / diagnosis. Hemangiosarcoma / diagnosis. Neoplasms, Second Primary / diagnosis. Radiotherapy / adverse effects
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Biomarkers, Tumor / metabolism. Biopsy, Fine-Needle. Cell Nucleus / pathology. Diagnosis, Differential. Epithelial Cells / pathology. Female. Humans. Immunohistochemistry / methods. Neoplasm Recurrence, Local / diagnosis

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  • (PMID = 17017445.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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10. Ordoñez-Escalante KG, Mantilla-Morales A, Gallegos F: [Nasal cavity angiosarcoma: a case report and literature review]. Gac Med Mex; 2006 Mar-Apr;142(2):155-8
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  • [Title] [Nasal cavity angiosarcoma: a case report and literature review].
  • [Transliterated title] Angiosarcoma de cavidad nasal: informe de un caso y revisión de la literatura.
  • Sarcomas constitute 5% of all of head and neck neoplasms.
  • Angiosarcomas comprise 2% of all soft tissue tumors, 60% appear in skin and soft tissue, 50% in the head and neck and only 4% are present in the upper aerodigestive tract.
  • The histopathologic diagnosis was angiosarcoma.
  • Agiosarcomas of the upper aerodigestive tract have a better prognosis and long term survival free of disease than their soft tissue and skin counterparts.
  • [MeSH-major] Hemangiosarcoma / diagnosis. Nasal Cavity. Nose Neoplasms / diagnosis

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  • (PMID = 16711550.001).
  • [ISSN] 0016-3813
  • [Journal-full-title] Gaceta médica de México
  • [ISO-abbreviation] Gac Med Mex
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Mexico
  • [Number-of-references] 22
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11. Hodgson NC, Bowen-Wells C, Moffat F, Franceschi D, Avisar E: Angiosarcomas of the breast: a review of 70 cases. Am J Clin Oncol; 2007 Dec;30(6):570-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcomas of the breast: a review of 70 cases.
  • OBJECTIVE: Angiosarcoma arising in the irradiated breast after breast-conserving therapy is being reported with increasing frequency.
  • The objective of this study was to review breast angiosarcomas diagnosed from 1981 to 2000 from our state cancer registry.
  • METHODS: A comprehensive review of a population-based registry, Florida Cancer Data System, identified 70 cases of breast angiosarcomas from 1981 to 2000.
  • RESULTS: Of the 70 cases at presentation, 39 were primary breast angiosarcomas (PBAs) and 31 were secondary breast angiosarcomas (SBAs).
  • In the SBA group the mean age of breast cancer diagnosis was 67.6.
  • The mean time to diagnosis of the angiosarcoma was 5.2 years after breast cancer irradiation.
  • At presentation 82% (n = 32) and 48% (n = 15), in the PBA and SBA groups, respectively had local disease (P = 0.003).
  • CONCLUSION: Angiosarcoma of the breast is rare and this study reports a review of 70 cases from 1980 to 2000.
  • Angiosarcoma after breast-conserving therapy is increasingly diagnosed in a small but significant portion of breast carcinoma survivors.
  • SBA patients present with more advance disease.
  • The aggressive nature of this disease demands further investigation of adjuvant therapy to prevent recurrence of disease after surgery.
  • [MeSH-major] Breast Neoplasms / etiology. Hemangiosarcoma / etiology. Mastectomy, Segmental / adverse effects. Neoplasms, Second Primary / etiology

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  • (PMID = 18091049.001).
  • [ISSN] 1537-453X
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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12. Le Corre Y, Avenel-Audran M, Croué A, Steff M, Verret JL: [Cutaneous angiosarcoma of the leg without lymphoedema]. Ann Dermatol Venereol; 2008 Jun-Jul;135(6-7):488-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Cutaneous angiosarcoma of the leg without lymphoedema].
  • [Transliterated title] Angiosarcome cutané de jambe sans lymphoedème associé.
  • BACKGROUND: Cutaneous angiosarcoma is a rare aggressive vascular neoplasm with a poor prognosis, seen chiefly in elderly subjects and usually on the scalp or face.
  • Histological examination showed vascular channels lined with atypical cells consistent with a diagnosis of angiosarcoma.
  • DISCUSSION: The leg is a rare site of cutaneous angiosarcoma.
  • [MeSH-major] Hemangiosarcoma. Leg. Skin Neoplasms

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  • (PMID = 18598799.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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13. Yang XJ, Zheng JW, Zhou Q, Ye WM, Wang YA, Zhu HG, Wang LZ, Zhang ZY: Angiosarcomas of the head and neck: a clinico-immunohistochemical study of 8 consecutive patients. Int J Oral Maxillofac Surg; 2010 Jun;39(6):568-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcomas of the head and neck: a clinico-immunohistochemical study of 8 consecutive patients.
  • Angiosarcoma, also known as malignant hemangioendothelioma, is a rare and aggressive malignant vascular tumour arising from endothelial cells, which accounts for approximately 10% of soft tissue sarcomas in the head and neck.
  • Between October 1996 and July 2008, 10 patients were diagnosed with angiosarcomas (AS) in the head and neck region, 8 of whom were included in this study (there were 7 high-grade and 1 low-grade lesions).
  • Of the 8 patients reviewed in this study, 5 died of local recurrence or distant metastasis with a survival time of 8-19 months, 2 patients are alive with disease and 1 patient is free of disease.
  • [MeSH-major] Biomarkers, Tumor / analysis. Head and Neck Neoplasms / chemistry. Head and Neck Neoplasms / pathology. Hemangiosarcoma / chemistry. Hemangiosarcoma / pathology

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  • (PMID = 20413272.001).
  • [ISSN] 1399-0020
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Antigens, CD34; 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 9001-27-8 / Factor VIII
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14. Vertse G, Svastics E, Iványi A: [Postirradiation angiosarcoma of the breast]. Magy Seb; 2010 Aug;63(4):164-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Postirradiation angiosarcoma of the breast].
  • [Transliterated title] Besugárzás utáni angiosarcoma emloben.
  • Although secondary angiosarcomas (AS) are relatively rare neoplasms, they are increasingly recognized as the result of more breast conserving therapy (BCT) followed by radiotherapy.
  • The diagnosis of this very aggressive and rapidly spreading tumour is based on the immunohystochemical characteristics of the biopsy specimen.
  • [MeSH-major] Breast Neoplasms / radiotherapy. Hemangiosarcoma / diagnosis. Hemangiosarcoma / etiology. Mastectomy, Segmental. Neoplasms, Second Primary / diagnosis. Neoplasms, Second Primary / etiology

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  • (PMID = 20724241.001).
  • [ISSN] 0025-0295
  • [Journal-full-title] Magyar sebészet
  • [ISO-abbreviation] Magy Seb
  • [Language] hun
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Hungary
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers, Tumor
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15. Agulnik M, Okuno SH, Von Mehren M, Jovanovic B, Brockstein B, Benjamin RS, Evens AM: An open-label multicenter phase II study of bevacizumab for the treatment of angiosarcoma. J Clin Oncol; 2009 May 20;27(15_suppl):10522

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An open-label multicenter phase II study of bevacizumab for the treatment of angiosarcoma.
  • : 10522 Background: The limited therapeutic options and dismal prognosis for patients (pts) with angiosarcomas (AS) provide a strong rationale for the evaluation of new therapies.
  • METHODS: The study was a two-stage design in which patients with newly diagnosed or relapsed/refractory AS and epithelioid hemangioendotheliomas were treated with bevacizumab 15 mg/kg IV every 3 weeks.
  • Further studies with bevacizumab in combination with chemotherapy should be explored in this disease.

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  • (PMID = 27963911.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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16. Patnaik A, Chiorean EG, Tolcher A, Papadopoulos K, Beeram M, Kee D, Waddell M, Gilles E, Buchbinder A: EZN-2968, a novel hypoxia-inducible factor-1α (HIF-1α) messenger ribonucleic acid (mRNA) antagonist: Results of a phase I, pharmacokinetic (PK), dose-escalation study of daily administration in patients (pts) with advanced malignancies. J Clin Oncol; 2009 May 20;27(15_suppl):2564

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Tumor types included colorectal cancer (7 pts); renal cancer (4 pts); soft-tissue sarcoma (STS; 2 pts); angiosarcoma (1 pt); melanoma (1 pt); and breast, ovarian, pancreatic, and prostate cancers (1 pt each).
  • Stable disease was observed for 1 pt with angiosarcoma (28 wks) and 1 pt with renal cancer (12 wks).
  • Durable stable disease has been observed.

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  • (PMID = 27961885.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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17. Indelicato DJ, Keole SR, Shahlaee AH, Morris CG, Gibbs CP, Scarborough MT, Islam S, Marcus RB: Ewing tumors of the chest wall: Local control and long-term outcomes. J Clin Oncol; 2009 May 20;27(15_suppl):e21501

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • : e21501 Background: Primary sarcomas of the lungs and mediastinum are rare and few data are reported on treatment and results of therapy.
  • Pts characteristics: median age 41 (19-80 y), male/female 19/12; symptoms at diagnosis: dyspnoea (42%), chest and shoulder pain (39%), cough (35%), hemophtoae (13%), discomfort (10%).
  • 5 mediastinal tumours were located as follows: 2 in anterior part, 1 in posterior and 2 in the middle (sarcomas of the heart).
  • 26 lung sarcomas presented as a singular mass in 23 cases and as a metastatic disease in 3.
  • RESULTS: In 20/31 cases the tumour was immediately resected (3 mediastinal masses and 17 lung sarcomas).
  • The histology were: peripheral nerve tumour 7, leiomyosarcoma 4, MFH 2, fibrosarcoma 2, liposarcoma 1, angiosarcoma 2, undifferentiated sarcoma 1, solitary fibrous tumour 2, rhabdomyosarcoma 2, synovialsarcoma 2, pulmonary artery sarcoma 1, pleuropolmonary blastoma 1, malignant hemangiopericytoma 1, mixoid chondrosarcoma 1, ectopic osteosarcoma 1, aggressive fibromatosis 1.
  • Only 4 pts received neoadjuvant chemotherapy, 11 adjuvant CT, 5 exclusive CT + RT for inoperable disease.
  • Of these only 8 are alive (2 with disease).
  • Volume of disease, complete resection and grading are the dominant prognostic factors.
  • CONCLUSIONS: Primary sarcomas of the lungs and mediastinum have a very severe prognosis.

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  • (PMID = 27963390.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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18. Comandone A, Boglione A, Pochettino P, Berno E, Inguì M, Papotti M, Borasio P, Maggi G, Brach Del Prever E, Gino G: Primary sarcomas of the lungs and mediastinum: Clinicopathological study and therapy results of Piedmontese Group for Sarcomas. J Clin Oncol; 2009 May 20;27(15_suppl):e21509

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary sarcomas of the lungs and mediastinum: Clinicopathological study and therapy results of Piedmontese Group for Sarcomas.
  • : e21509 Background: Primary sarcomas of the lungs and mediastinum are rare and few data are reported on treatment and results of therapy.
  • Pts characteristics: median age 41 (19-80 y), male/female 19/12; symptoms at diagnosis: dyspnoea (42%), chest and shoulder pain (39%), cough (35%), hemophtoae (13%), discomfort (10%).
  • 5 mediastinal tumours were located as follows: 2 in anterior part, 1 in posterior and 2 in the middle (sarcomas of the heart).
  • 26 lung sarcomas presented as a singular mass in 23 cases and as a metastatic disease in 3.
  • RESULTS: In 20/31 cases the tumour was immediately resected (3 mediastinal masses and 17 lung sarcomas).
  • The histology were: peripheral nerve tumour 7, leiomyosarcoma 4, MFH 2, fibrosarcoma 2, liposarcoma 1, angiosarcoma 2, undifferentiated sarcoma 1, solitary fibrous tumour 2, rhabdomyosarcoma 2, synovialsarcoma 2, pulmonary artery sarcoma 1, pleuropolmonary blastoma 1, malignant hemangiopericytoma 1, mixoid chondrosarcoma 1, ectopic osteosarcoma 1, aggressive fibromatosis 1.
  • Only 4 pts received neoadjuvant chemotherapy, 11 adjuvant CT, 5 exclusive CT + RT for inoperable disease.
  • Of these only 8 are alive (2 with disease).
  • Volume of disease, complete resection and grading are the dominant prognostic factors.
  • CONCLUSIONS: Primary sarcomas of the lungs and mediastinum have a very severe prognosis.

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  • (PMID = 27963441.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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19. Erbersdobler A, Simon R, Hellwinkel OJ, Bokemeyer C, Sauter G, Hu-Lowe D, Levin W, Gallo-Stampino C, Fiedler W: Analysis of expression of TGF-β1 receptor (ALK-1) in normal and tumor tissues by tissue microarrays. J Clin Oncol; 2009 May 20;27(15_suppl):e22044

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Activin-like kinase I (ALK-1) is a class I TGF- β1 receptor which is almost exclusively expressed on endothelial cells.
  • The highest ALK-1 expression rate was found in lung cancer (NSCLC 49%, SCLC 83%), neuroendocrine pancreas tumor (71%), colon cancer (50%), chondrosarcoma 50%, angiosarcoma 40% and NHL (44%).

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  • (PMID = 27963226.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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20. Pink D, Rahm J, Schoeler D, Schoenknecht TM, Reichardt P: Activity of paclitaxel in radiation induced and other secondary angiosarcomas. J Clin Oncol; 2009 May 20;27(15_suppl):10578

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Activity of paclitaxel in radiation induced and other secondary angiosarcomas.
  • : 10578 Background: Angiosarcomas (AS) represent 1-2% of adult soft tissue sarcomas and can arise anywhere in the body.
  • Paclitaxel has shown an exceptionally high activity of 75-89% in angiosarcomas of the face and scalp and to a lesser and less consitent degree of 15-58% in other disease locations.
  • We report on a retrospectice single center experience with chemotherapy in 17 patients (pts.) with secondary angiosarcomas (SAS).
  • 12 female patients suffered from angiosarcoma of the breast/thoracic wall following operation and radiation + chemotherapy of a primary breast cancer with an interval of a median of 6 years (range 2-15 years).
  • 3 pts. remain free of disease.
  • All 14 patients with recurrent/metastatic disease were treated with chemotherapy.
  • Responses were 8 PR with a median PFS of 6 months (range 3-23 months), and 1 SD (PFS 4 months) with a disease control rate of 75%.
  • CONCLUSIONS: Paclitaxel shows high activity in SAS, comparable to the results in face and scalp angiosarcomas and can be considered a standard treatment option.

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  • (PMID = 27963758.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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21. Galaychuk I: Breast sarcomas: Is now the time to change our mind? J Clin Oncol; 2009 May 20;27(15_suppl):e21524

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Breast sarcomas: Is now the time to change our mind?
  • : e21524 Background: Primary breast sarcoma usually was considered a rare malignant disease [Adem et al., 2004].
  • The aim of this study is to show the incidence of breast sarcoma in the region with female population of about 600,000.
  • METHODS: Retrospective comparative analysis of breast sarcoma and breast cancer incidence in female of Ternopil region for 2000 - 2008.
  • RESULTS: The total of 101 cases of breast sarcoma was diagnosed in female of 39 - 76 years of age.
  • Every year about 11 (6-18) primary breast sarcomas and 256 (233-279) patients with primary breast cancer were detected.
  • The incidence rate of breast sarcoma was 1.14 per 100,000 women in 2000, 2.94 (in 2001), 1.48 (2002), 0.99 (2003), 2.16 (2004), 1.67 (2005), 2.53 (2006), 2.03 (2007) and 1.87/100,000 in 2008.
  • Breast sarcoma consisted of 2.5% of the breast malignancies in 2000, 6.5% (in 2001), 3.3% (2002), 2.6% (2003), 5.4% (2004), 4.1% (2005), 5.9% (2006), 4.4% (2007) and 4.7% in 2008.
  • Pathohistologic examination revealed angiosarcoma in 92.1% of cases.
  • Thus, our findings are significantly different than data of other authors: f.e., the incidence of primary breast sarcoma is at 45 new cases per 10 million women [Confavreux et al., 2003], or 17 new cases per million women [Moore and Kinne, 1996], and breast sarcoma accounting for 0.0006% of breast malignancies which were diagnosed in 1910-2000 [Adem, 2004].
  • Taking into account all historical and recent data we can suggest beginning of biological changing in correlation between breast malignant tumors-carcinoma and sarcoma.
  • CONCLUSIONS: Our statistical finding shows that incidence of breast sarcoma is 1.87 (0.99-2.94) per of 100,000 female population, and now sarcomas consist of 4.4% (2.5-6.5%) of all malignant breast tumors.
  • Angiosarcoma is a most common (92.1%) morphological type of breast sarcomas.

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  • (PMID = 27963454.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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22. Ramon Y Cajal T, Mazarico J, Lopez Pousa A, Quintana M, Sala N, Altabas M, Sebio A, Robert L, Alonso C, Barnadas A: Clinical features and outcome in primary breast sarcomas (BS): Analysis of a single-institution experience. J Clin Oncol; 2009 May 20;27(15_suppl):e21520

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical features and outcome in primary breast sarcomas (BS): Analysis of a single-institution experience.
  • Pathology: 17 cistosarcoma phylodes (CPh), 9 angiosarcoma, 2 extraesqueletical osteosarcoma, 2 fibrosarcomas, 1 liposarcoma, 1 leiomiosarcoma, 1 malignant fibrous histiocitoma (2.9%).

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  • (PMID = 27963450.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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23. Moreno-Vega A, Chavarría N, Rubio J, Villandiego I, Estepa R, Gordon M, Salvador J, Jimenez E: Primary breast sarcoma: Clinical and retrospective analysis of cases from Jerez General Hospital, Spain. J Clin Oncol; 2009 May 20;27(15_suppl):e21526

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary breast sarcoma: Clinical and retrospective analysis of cases from Jerez General Hospital, Spain.
  • : e21526 Background: Primary sarcomas of the breast (PBS) are a heterogeneous group of tumors from stromal breast, infrequent (0.1% of BC).
  • Diagnosis and treatment is unclear.
  • We analysed diseases outcomes (disease free survival, DFS) by histology high risk factors (tumor size, histology, and proliferation index).
  • RESULTS: Seven cases of PBS (1 male/6 female) were reviewed, from 790 BC diagnosed (0.8%): 2 angiosarcomas (AS), 1 malignant fibrous histiocytoma, 2 undifferentiated, one osteoclastic and other spindle-cell sarcoma.
  • CONCLUSIONS: PBS are rare and difficult diagnosis tumors.
  • There are few series published, without prospective studies to evaluate an adequate therapy, diagnosis and valuable prognostic factors.
  • Our incidence was high, but the independent pathology analysis confirmed all histopathological diagnosis.
  • This review included novel IHC and IRM images, considered necessary for diagnosis and personalized treatment.

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  • (PMID = 27963456.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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24. McIntosh BC, Narayan D: Head and neck angiosarcomas. J Craniofac Surg; 2005 Jul;16(4):699-703
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Head and neck angiosarcomas.
  • Angiosarcoma of the head and neck is a rare and lethal neoplasm.
  • Data from the Connecticut Tumor Registry was analyzed for all head and neck angiosarcomas between 1980 and 2001.
  • The authors also present the first reported case of familial angiosarcoma of the head and neck region.
  • The 1-year mortality was 48% for all patients with angiosarcomas (38% for males, 69% for females).
  • [MeSH-major] Head and Neck Neoplasms / epidemiology. Hemangiosarcoma / epidemiology
  • [MeSH-minor] Adult. Age Distribution. Aged. Chemotherapy, Adjuvant. Connecticut / epidemiology. Disease-Free Survival. Female. Humans. Incidence. Male. Middle Aged. Sex Distribution. Siblings

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  • (PMID = 16077321.001).
  • [ISSN] 1049-2275
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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25. Hindersin S, Schubert O, Cohnen M, Felsberg J, Schipper J, Hoffmann TK: [Angiosarcoma of the temporal bone]. Laryngorhinootologie; 2008 May;87(5):345-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Angiosarcoma of the temporal bone].
  • [Transliterated title] Angiosarkom des Os temporale.
  • Angiosarcoma of the temporal bone is an extremely rare malignant tumor, which originates from vascular endothelium.
  • After subtotal mastoidectomy histological examination revealed an angiosarcoma of the mastoid.
  • In this manuscript the morphology, imaging characteristics and current treatment options of angiosarcomas of the lateral skull base are reviewed and discussed.
  • [MeSH-major] Hemangiosarcoma / surgery. Skull Neoplasms / surgery. Temporal Bone / surgery
  • [MeSH-minor] Diagnosis, Differential. Disease Progression. Facial Paralysis / etiology. Fatal Outcome. Female. Hearing Loss, Sudden / etiology. Humans. Mastoid / pathology. Mastoid / surgery. Meninges / pathology. Middle Aged. Neck Dissection. Neoplasm Invasiveness. Neoplasm Staging

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  • (PMID = 18509895.001).
  • [ISSN] 0935-8943
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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26. Leibl S, Moinfar F: Mammary NOS-type sarcoma with CD10 expression: a rare entity with features of myoepithelial differentiation. Am J Surg Pathol; 2006 Apr;30(4):450-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mammary NOS-type sarcoma with CD10 expression: a rare entity with features of myoepithelial differentiation.
  • We present an extensive immunohistochemical analysis of 7 mammary sarcomas that did not fit into any specific soft tissue sarcoma category.
  • Other myoepithelial markers and steroid receptors were absent, except androgen receptors, which were expressed in one sarcoma.
  • Five sarcomas showed positivity for EGFR.
  • The distinction of specific, histogenetically defined sarcoma entities (such as leiomyosarcoma, angiosarcoma, liposarcoma) from NOS-type sarcoma with CD10 expression is usually clear-cut because the former exhibit a characteristic histomorphology and immunoprofile.
  • Phyllodes tumors with stromal overgrowth or recurrent phyllodes tumors lacking epithelial structures as well as periductal stromal sarcomas can be ruled out by their frequent expression of CD34 and negativity for myoepithelial markers.
  • The most important differential diagnosis is sarcomatoid metaplastic carcinoma because its treatment includes axillary lymphadenectomy.
  • Since some NOS-type sarcomas with CD10 expression and most metaplastic carcinomas show positivity for CD29, SMA, and p63, differential diagnosis can be extremely difficult and requires extensive immunohistochemical evaluation for CKs and additional myoepithelial markers such as S-100, 14-3-3sigma, and maspin.
  • The immunophenotype of NOS-type sarcomas with CD10 expression suggests that these neoplasms represent a mammary sarcoma variant with myoepithelial features.
  • [MeSH-major] Breast Neoplasms / pathology. Myoepithelioma / pathology. Neprilysin / metabolism. Sarcoma / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Carcinosarcoma / diagnosis. Cell Transformation, Neoplastic. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Middle Aged


27. Herrak L, Alaziz S, Benosmane A: [Primary pulmonary angiosarcoma]. Rev Mal Respir; 2007 Jan;24(1):73-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Primary pulmonary angiosarcoma].
  • [Transliterated title] Angiosarcome pulmonaire primitif.
  • INTRODUCTION: Primary pulmonary angiosarcoma (PPA) is a very rare tumour with a grave and short prognosis and whose primary site is difficult to confirm.
  • The diagnosis is essentially histological and immunohistochemical because there are no specific clinical or radiological signs.
  • The diagnosis was made by histological and immunohistochemical analysis of CT guided percutaneous biopsies.
  • [MeSH-major] Hemangiosarcoma / pathology. Lung Neoplasms / pathology

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  • (PMID = 17268369.001).
  • [ISSN] 0761-8425
  • [Journal-full-title] Revue des maladies respiratoires
  • [ISO-abbreviation] Rev Mal Respir
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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28. Bouhaouala MH, Charfi MR, Fajraoui N, Bouaziz N, Boukhris A, Kilani T: [Primary pulmonary angiosarcoma]. Rev Pneumol Clin; 2005 Apr;61(2):115-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Primary pulmonary angiosarcoma].
  • [Transliterated title] Angiosarcome pulmonaire primitif.
  • Pulmonary angiosarcoma is an uncommon vascular and usually secondary tumor.
  • Only a few primary cases of pulmonary angiosarcoma have been described.
  • We report a case of primary pulmonary angiosarcoma in an adult man who presented with hemoptysis.
  • Pulmonary angiosarcoma was diagnosed on histological and immuno-histochemical studies of the operative specimen.
  • This observation is added to the other rare cases published of primitive pulmonary angiosarcoma.
  • [MeSH-major] Hemangiosarcoma / diagnosis. Lung Neoplasms / diagnosis

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  • (PMID = 16012366.001).
  • [ISSN] 0761-8417
  • [Journal-full-title] Revue de pneumologie clinique
  • [ISO-abbreviation] Rev Pneumol Clin
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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29. Driemel O, Berndt A, Hartmann A, Mueller-Richter UD, Bauer R, Reichert TE, Kosmehl H: [Clinical and immunohistochemical findings of intra- and extraoral angiosarcomas]. Mund Kiefer Gesichtschir; 2006 Jul;10(4):239-47
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinical and immunohistochemical findings of intra- and extraoral angiosarcomas].
  • PURPOSE: A clinico-pathologic study of typical symptoms of intra- and extraoral angiosarcomas and clinical course under therapy is presented as well as an analysis of the immunohistochemical differential diagnosis of the tumour specific formed spaces.
  • PATIENTS AND METHODS: Four male patients aged 63-78 years suffered from angiosarcomas of the maxillary sinus, the bucca (two patients) and the alveolar ridge of the lower jaw.
  • RESULTS: While the benign appearance of the lesions resulted primarily in wrong diagnoses the histopathologic examination of the biopsies revealed the characteristic pattern of angiosarcomas.
  • Wide surgical excision, radiotherapy and/or antiangiogenic chemotherapy could not prevent tumour progression and death within two and a half years after primary diagnosis.
  • All angiosarcomas reacted partially positive for factor-VIII-related antigen and CD31.
  • ) The variable presentation and the benign appearance of oral and perioral angiosarcomas may often delay diagnosis.
  • Oral and perioral angiosarcomas show poor prognosis despite of multimodal therapy. (2.
  • ) Cytoceratin and laminin-5-positivity as typical epithelial antigens don't exclude angiosarcoma.
  • Factor-VIII-related antigen, CD31 as well as Fli-1 identify angiosarcoma. (3.) alpha-smooth-muscle-actin and the loss of the tenascin-C-matrix indicate immunohistochemically the characteristic sarcomatous defect of differentiation.
  • [MeSH-major] Alveolar Process. Biomarkers, Tumor / analysis. Cheek. Hemangiosarcoma / pathology. Mandibular Neoplasms / pathology. Maxillary Sinus Neoplasms / pathology. Mouth Neoplasms / pathology

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  • (PMID = 16788797.001).
  • [ISSN] 1432-9417
  • [Journal-full-title] Mund-, Kiefer- und Gesichtschirurgie : MKG
  • [ISO-abbreviation] Mund Kiefer Gesichtschir
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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30. El Harroudi T, Moumen M, Tijami F, El Otmany A, Jalil A: [Giant epithelioid hemangioma of the hand]. Chir Main; 2008 Oct;27(5):240-2
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  • Epithelioid vascular tumors are a heterogeneous group characterized by epithelioid-appearing endothelial cells.
  • Included are benign vascular tumors (epithelioid haemangioma), borderline tumors (epithelioid haemangioendothelioma), and malignant tumors (epithelioid angiosarcoma).

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  • (PMID = 18849180.001).
  • [ISSN] 1297-3203
  • [Journal-full-title] Chirurgie de la main
  • [ISO-abbreviation] Chir Main
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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31. Baumhoer D, Gunawan B, Becker H, Füzesi L: Comparative genomic hybridization in four angiosarcomas of the female breast. Gynecol Oncol; 2005 May;97(2):348-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparative genomic hybridization in four angiosarcomas of the female breast.
  • OBJECTIVE: Angiosarcomas represent a heterogeneous group of malignant vascular tumors occurring in different anatomic sites.
  • In the female breast, they account for less than 1% of all malignant tumors and mainly develop as secondary angiosarcomas after prior irradiation.
  • Data on cytogenetic findings in angiosarcomas are scarce and up to now no characteristic primary aberrations have been established.
  • We herein add molecular cytogenetic findings in another 4 angiosarcomas to 11 previously reported cases.
  • METHODS: We investigated four angiosarcomas of the female breast (three primary angiosarcomas and one secondary tumor after irradiation for breast cancer) for DNA copy number changes using comparative genomic hybridization (CGH).
  • RESULTS: All angiosarcomas revealed aberrant karyotypes including multiple DNA copy number changes involving various chromosomes.
  • CONCLUSIONS: Angiosarcoma of the female breast represents a genetically heterogeneous tumor entity without a readily identifiable pattern of common chromosomal alterations.
  • However, reviewing the cytogenetic literature on angiosarcomas of different sites, gains at 8q and 20p appear to emerge as the most frequent aberrations in at least a subset of these tumors.
  • [MeSH-major] Breast Neoplasms / genetics. Hemangiosarcoma / genetics

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  • (PMID = 15863129.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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32. Biswas T, Tang P, Muhs A, Ling M: Angiosarcoma of the breast: a rare clinicopathological entity. Am J Clin Oncol; 2009 Dec;32(6):582-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma of the breast: a rare clinicopathological entity.
  • OBJECTIVES: Angiosarcoma is a rare subtype of sarcoma that usually arises after radiation therapy for primary breast cancer.
  • Primary sarcomas of the breast are rare entities and account for less than 1% of all malignant breast neoplasms.
  • We examine our institutional experience with angiosarcomas of the breast that were diagnosed and treated between 1996 and 2007.
  • METHODS: To conduct a retrospective review, all female patients with a diagnosis of angiosarcoma of the breast were identified from our pathology database.
  • RESULTS: A total of 8 patients were identified who had a histologically confirmed diagnosis of angiosarcoma of the breast.
  • Median age was 70.3 years at diagnosis (range, 35.6-85.7 years).
  • Seven (87%) patients had a history of prior radiation to the breast, whereas 1 (13%) had primary angiosarcoma.
  • CONCLUSIONS: Even though angiosarcomas are rare neoplasms, they are increasingly recognized as the result of more breast-conserving therapy.
  • High clinical suspicion and MRI may contribute to early diagnosis but a biopsy is always necessary to confirm it.
  • [MeSH-major] Breast Neoplasms / pathology. Hemangiosarcoma / pathology. Neoplasms, Radiation-Induced / pathology. Neoplasms, Second Primary / pathology

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  • (PMID = 19581792.001).
  • [ISSN] 1537-453X
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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33. Young RJ, Brown NJ, Reed MW, Hughes D, Woll PJ: Angiosarcoma. Lancet Oncol; 2010 Oct;11(10):983-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma.
  • Angiosarcomas are rare soft-tissue sarcomas of endothelial cell origin that have a poor prognosis.
  • They can arise anywhere in the body, most commonly presenting as cutaneous disease in elderly white men, involving the head and neck and particularly the scalp.
  • They can be caused by therapeutic radiation or chronic lymphoedema and hence secondary breast angiosarcomas are an important subgroup.
  • Recent work has sought to establish the molecular biology of angiosarcomas and identify specific targets for treatment.
  • Interest is now focused on trials of vascular-targeted drugs, which are showing promise in the control of angiosarcomas.
  • In this review we discuss angiosarcoma and its current management, with a focus on clinical trials investigating the treatment of advanced disease.
  • [MeSH-major] Hemangiosarcoma / therapy
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Male. Neoplasm Staging. Predictive Value of Tests. Risk Factors. Treatment Outcome

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  • [Copyright] Copyright © 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20537949.001).
  • [ISSN] 1474-5488
  • [Journal-full-title] The Lancet. Oncology
  • [ISO-abbreviation] Lancet Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
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34. Shin SJ, Lesser M, Rosen PP: Hemangiomas and angiosarcomas of the breast: diagnostic utility of cell cycle markers with emphasis on Ki-67. Arch Pathol Lab Med; 2007 Apr;131(4):538-44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hemangiomas and angiosarcomas of the breast: diagnostic utility of cell cycle markers with emphasis on Ki-67.
  • CONTEXT: Vascular tumors comprise a minor subgroup of tumors arising in the breast and represent variants of hemangiomas and angiosarcomas.
  • Diagnostic challenges may arise when differentiating hemangiomas from types I and II angiosarcomas.
  • Ki-67 expression has been used as an adjunct to distinguish between benign and malignant lesions exhibiting histologic overlap at various anatomic sites.
  • OBJECTIVE: To investigate the utility of Ki-67 and other cell cycle regulatory proteins (S-phase kinase-associated protein 2 [Skp2], p27, and cyclin D1) in the differential diagnosis of mammary vascular lesions.
  • DESIGN: Thirty-four vascular tumors (21 hemangiomas and 13 angiosarcomas) of the breast were studied.
  • RESULTS: The mean value of Ki-67 index was statistically different when comparing hemangiomas and angiosarcomas (P < .001).
  • Angiosarcomas were typically positive for Skp2, whereas hemangiomas were negative (P < .001).
  • Sensitivity and specificity cutoffs for Ki-67 index to distinguish hemangiomas from angiosarcomas showed a candidate cutoff point of 175.
  • The mean values of Ki-67 of low-grade angiosarcomas were significantly different from all hemangiomas (P < .001) and also different from the subset of atypical hemangiomas (P = .02).
  • Sensitivity and specificity cutoffs for Ki-67 index to distinguish all hemangiomas from low-grade angiosarcomas showed a candidate cutoff point between 150 and 175.
  • Among angiosarcomas, positivity for Ki-67 was inversely related to that of p27 but not to Skp2 or cyclin D1.
  • CONCLUSIONS: Ki-67 index can be used as a diagnostic tool to distinguish between benign and malignant vascular lesions of the breast.
  • This can be particularly helpful in cases of histologic overlap such as low-grade angiosarcoma and hemangioma.
  • [MeSH-major] Breast Neoplasms / diagnosis. Breast Neoplasms, Male / diagnosis. Hemangioma / diagnosis. Hemangiosarcoma / diagnosis. Ki-67 Antigen / metabolism
  • [MeSH-minor] Biomarkers, Tumor / analysis. Cell Cycle. Cyclin D1 / metabolism. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Middle Aged. Proliferating Cell Nuclear Antigen / metabolism. S-Phase Kinase-Associated Proteins / metabolism. Sensitivity and Specificity

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  • (PMID = 17425381.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / Proliferating Cell Nuclear Antigen; 0 / S-Phase Kinase-Associated Proteins; 0 / p27 antigen; 136601-57-5 / Cyclin D1
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35. Penel N, Lansiaux A, Adenis A: Angiosarcomas and taxanes. Curr Treat Options Oncol; 2007 Dec;8(6):428-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcomas and taxanes.
  • Angiosarcomas (AS) are a heterogeneous group of rare and aggressive malignancies.
  • The French Sarcoma Group has conducted a phase II clinical trial, which states the benefit of weekly paclitaxel in patients with unresectable or metastatic AS.
  • [MeSH-major] Antineoplastic Agents, Phytogenic / therapeutic use. Hemangiosarcoma / drug therapy. Taxoids / therapeutic use
  • [MeSH-minor] Antibiotics, Antineoplastic / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Disease-Free Survival. Doxorubicin / administration & dosage. Humans. Paclitaxel / therapeutic use. Radiotherapy, Adjuvant

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  • (PMID = 18066504.001).
  • [ISSN] 1534-6277
  • [Journal-full-title] Current treatment options in oncology
  • [ISO-abbreviation] Curr Treat Options Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Antineoplastic Agents, Phytogenic; 0 / Taxoids; 15H5577CQD / docetaxel; 80168379AG / Doxorubicin; P88XT4IS4D / Paclitaxel
  • [Number-of-references] 40
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36. Elawar A, Dandurand M, Jumez N, Delfour C, Branchereau P, Stoebner P, Meunier L: [Cutaneous metastasis revealing epithelioid angiosarcoma of the abdominal aorta]. Ann Dermatol Venereol; 2010 Feb;137(2):111-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Cutaneous metastasis revealing epithelioid angiosarcoma of the abdominal aorta].
  • [Transliterated title] Métastases cutanées révélatrices d'un angiosarcome épithélioïde de l'aorte abdominale.
  • BACKGROUND: Epithelioid angiosarcomas (EAS) of the aorta are a rare form of tumour usually diagnosed by histopathological analysis of the aorta.
  • The course of the disease involved distal ischaemia.
  • Histological examination of a nodule showed proliferation of malignant cells with expression of vimentin, CD 31, cytokeratins AE1/AE3 and cytokeratin 7.
  • These findings suggested a diagnosis of EAS of the aorta with skin and osseous metastasis and vascular emboli.
  • Skin metastasis causes papular eruption, nodules and peripheral vascular disease.
  • Our case report emphasizes four key points: the diagnostic value of an association of localized malignant skin tumours, extensive livedo, ipsilateral distal ischaemia, deterioration of the general condition and intense pain; the diagnostic value of endothelial markers, especially CD31, and potentially misleading co-expression of cytokeratin markers; in selected cases, additional imaging, such as PET scans, performed in our case for the first time prior to surgery of the aorta, may be helpful for the diagnosis of such neoplastic lesions of the aortic wall.
  • [MeSH-major] Aorta, Abdominal / pathology. Hemangiosarcoma / pathology. Hemangiosarcoma / secondary. Skin Neoplasms / secondary. Vascular Neoplasms / pathology

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  • [Copyright] Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20171432.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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37. Rodríguez-Bujaldón A, Vázquez-Bayo MC, Galán-Gutiérrez M, Jiménez-Puya R, Vélez García-Nieto A, Moreno-Giménez JC, Vidal-Jiménez A, Barroso-Casamitjana E: [Angiosarcoma in chronic lymphedema]. Actas Dermosifiliogr; 2006 Oct;97(8):525-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Angiosarcoma in chronic lymphedema].
  • [Transliterated title] Angiosarcoma sobre linfedema crónico.
  • Angiosarcoma that develops on a limb with chronic lymphedema is called Stewart-Treves syndrome.
  • The first corresponds to a typical syndrome of Stewart-Treves in an 83-year-old woman who was diagnosed of angiosarcoma in a chronic lymphedema territory secondary to mastectomy and radiotherapy due to breast cancer.
  • The second case is much rarer, since it is a case of diffuse angiosarcoma of the leg in a 42-year-old man with a history of lymphedema.
  • [MeSH-major] Hemangiosarcoma / etiology. Lymphedema / complications
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antibiotics, Antineoplastic / administration & dosage. Antibiotics, Antineoplastic / therapeutic use. Antineoplastic Agents, Alkylating / administration & dosage. Antineoplastic Agents, Alkylating / therapeutic use. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Arm. Doxorubicin / administration & dosage. Doxorubicin / therapeutic use. Female. Humans. Ifosfamide / administration & dosage. Ifosfamide / therapeutic use. Immunohistochemistry. Leg. Male. Skin / pathology. Skin Neoplasms / diagnosis. Skin Neoplasms / drug therapy. Skin Neoplasms / etiology. Skin Neoplasms / pathology. Skin Neoplasms / radiotherapy. Treatment Outcome

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  • (PMID = 17067532.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Antineoplastic Agents, Alkylating; 80168379AG / Doxorubicin; UM20QQM95Y / Ifosfamide
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38. Arbiser JL, Bonner MY, Berrios RL: Hemangiomas, angiosarcomas, and vascular malformations represent the signaling abnormalities of pathogenic angiogenesis. Curr Mol Med; 2009 Nov;9(8):929-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hemangiomas, angiosarcomas, and vascular malformations represent the signaling abnormalities of pathogenic angiogenesis.
  • Angiogenesis is a major factor in the development of benign, inflammatory, and malignant processes of the skin.
  • Endothelial cells are the effector cells of angiogenesis, and understanding their response to growth factors and inhibitors is critical to understanding the pathogenesis and treatment of skin disease.
  • Hemangiomas, benign tumors of endothelial cells, represent the most common tumor of childhood.
  • Furthermore, we have studied malignant vascular tumors, including hemangioendothelioma and angiosarcoma and have shown distinct signaling abnormalities in these tumors.
  • The incidence of these tumors is expected to rise due to environmental insults, such as radiation and lumpectomy for breast cancer, dietary and industrial carcinogens (hepatic angiosarcoma), and chronic ultraviolet exposure and potential Agent Orange exposure.
  • I hypothesize that hemangiomas, angiosarcomas, and vascular malformations represent the extremes of signaling abnormalities seen in pathogenic angiogenesis.
  • [MeSH-major] Hemangioma / blood supply. Hemangiosarcoma / blood supply. Neovascularization, Pathologic / pathology. Signal Transduction. Vascular Malformations / physiopathology

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  • (PMID = 19925405.001).
  • [ISSN] 1875-5666
  • [Journal-full-title] Current molecular medicine
  • [ISO-abbreviation] Curr. Mol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 81
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39. Taylor KL, Oates RK, Grane R, Leaman DW, Borden EC, Lindner DJ: IFN-alpha1,8 inhibits tumor-induced angiogenesis in murine angiosarcomas. J Interferon Cytokine Res; 2006 May;26(5):353-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] IFN-alpha1,8 inhibits tumor-induced angiogenesis in murine angiosarcomas.
  • Interferon-alpha (IFN-alpha) has proved effective in the treatment of hemangiomas, hemangioblastomas, and Kaposi's sarcoma.
  • To investigate the ability of IFNs to inhibit angiosarcoma, we used two transformed murine endothelial cell lines that form angiosarcomas in vivo.
  • SVR and MS1-VEGF cell lines express oncogenic H-ras or vascular endothelial growth factor (VEGF), respectively.
  • Both recombinant IP-10 and IFN-alpha1,8 inhibited human umbilical vein endothelial cell (HUVEC) vessel formation in the fibrin gel assay, a three-dimensional culture model of angiogenesis, by 56% at 25 ng/mL and 50% at 1.2 ng/mL, respectively (p < 0.001).
  • [MeSH-major] Hemangiosarcoma / blood supply. Hemangiosarcoma / drug therapy. Interferon-alpha / therapeutic use. Neovascularization, Pathologic / drug therapy
  • [MeSH-minor] Animals. Cell Line, Tumor. Cell Proliferation / drug effects. Chemokine CXCL10. Chemokines, CXC / biosynthesis. Chemokines, CXC / blood. Disease Progression. Humans. Mice. Xenograft Model Antitumor Assays

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  • (PMID = 16689662.001).
  • [ISSN] 1079-9907
  • [Journal-full-title] Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research
  • [ISO-abbreviation] J. Interferon Cytokine Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01CA089344-04
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chemokine CXCL10; 0 / Chemokines, CXC; 0 / Interferon-alpha
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40. Markidou S, Karydas I, Papadopoulos S, Christodoulidou I, Skarpidi E, Maounis N: Fine needle aspiration cytology in primary breast angiosarcoma: a case report. Acta Cytol; 2010 Sep-Oct;54(5 Suppl):764-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fine needle aspiration cytology in primary breast angiosarcoma: a case report.
  • BACKGROUND: Angiosarcoma of the breast is an uncommon, aggressive, vascular tumor.
  • The cytomorphologic features of angiosarcomas have rarely been reported.
  • CASE: The present study describes a case of breast angiosarcoma initially diagnosed by fine needle aspiration cytology.
  • Angiosarcoma appeared in the left breast of a 58-year-old woman after 12 years of a mastectomy (without radiotherapy) of the contralateral breast for invasive ductal carcinoma.
  • Both cell types exhibited immunoreactivity for endothelial markers.
  • The diagnosis of angiosarcoma was confirmed by histopathology of the surgically excised tumor.
  • CONCLUSION: Angiosarcoma rarely occurs in the breast, and a definitive diagnosis is extremely difficult relying exclusively on cytologic features.
  • Predominance of epithelioid cells may suggest an epithelial tumor, especially in patients with a history of breast carcinoma, whereas predominance of spindle cells can be misinterpreted as phyllodes tumor or another type of sarcoma.
  • Cell block immunocytochemistry and tumor cell labeling with endothelial markers are necessary for accurate diagnosis.
  • [MeSH-major] Breast / pathology. Breast Neoplasms / pathology. Hemangiosarcoma / pathology
  • [MeSH-minor] Biopsy, Fine-Needle. Diagnosis, Differential. Epithelial Cells / pathology. Female. Humans. Immunohistochemistry. Mastectomy. Middle Aged

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  • (PMID = 21053536.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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41. Hayn MH, Bastacky S, Franks ME: Epididymal angiosarcoma. Urology; 2007 Mar;69(3):576.e5-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epididymal angiosarcoma.
  • Sarcomas are rare and account for approximately 1% of all malignancies.
  • The subtype angiosarcoma is derived from vascular and lymphatic tissue and generally has a poor prognosis.
  • Prior radiation therapy is a known risk factor for the development of angiosarcomas.
  • We present what we believe to be the first case of an angiosarcoma arising in the epididymis in an 80-year-old man who presented with right scrotal swelling.
  • [MeSH-major] Epididymis. Genital Neoplasms, Male / surgery. Hemangiosarcoma / surgery. Neoplasms, Second Primary / surgery

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  • (PMID = 17382180.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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42. Astudillo L, Cron C, Gomez-Brouchet A, Couret B, Arlet-Suau E: [Angiosarcoma of the aorta]. Rev Med Interne; 2007 Oct;28(10):718-20

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Angiosarcoma of the aorta].
  • [Transliterated title] Angiosarcome épithélioïde de l'aorte.
  • Histopathology revealed an epithelioid angiosarcoma of the aorta.

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  • (PMID = 17587469.001).
  • [ISSN] 0248-8663
  • [Journal-full-title] La Revue de medecine interne
  • [ISO-abbreviation] Rev Med Interne
  • [Language] FRE
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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43. Al-Abbadi MA, Almasri NM, Al-Quran S, Wilkinson EJ: Cytokeratin and epithelial membrane antigen expression in angiosarcomas: an immunohistochemical study of 33 cases. Arch Pathol Lab Med; 2007 Feb;131(2):288-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytokeratin and epithelial membrane antigen expression in angiosarcomas: an immunohistochemical study of 33 cases.
  • CONTEXT: Expression of epithelial cell markers can occur in mesenchymal tumors and has been reported in angiosarcomas with variable frequency.
  • In these situations, establishing the diagnosis becomes problematic.
  • OBJECTIVE: To determine the expression of cytokeratin and epithelial membrane antigen in angiosarcoma.
  • DESIGN: To address this issue, 33 well-documented cases of angiosarcomas were retrieved from the archival material of Shands Hospital at the University of Florida, Gainesville, and Jackson Memorial Hospital at the University of Miami, Miami, Florida.
  • CONCLUSION: Cytokeratin and epithelial membrane antigen immunoreactivity in angiosarcomas is infrequent but may be encountered.
  • Interpretation of such expression should be done with caution and in conjunction with the characteristic clinical and morphologic features of the tumor as well as the expression of endothelial cell antigens.
  • [MeSH-major] Biomarkers, Tumor / analysis. Hemangiosarcoma / pathology. Keratins / metabolism. Mucin-1 / metabolism

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  • (PMID = 17284115.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Mucin-1; 68238-35-7 / Keratins
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44. Böge G, Gallix B, Gresillon C, Khau Van Kien A, Veerapen R, Quéré I: [Primary angiosarcoma of the aorta]. Vasa; 2007 Feb;36(1):33-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Primary angiosarcoma of the aorta].
  • [Transliterated title] Primäres Angiosarkom der Aorta.
  • Primary angiosarcoma of the aorta is a rare disease.
  • The prognosis is poor, resulting of embolic complications and early metastatic disease, with a median survival of nine months.
  • Diagnosis is difficult and often made post-mortem.
  • We report the case of a 68-year-old woman referred for a thrombosis of the superior mesenteric artery, occurring a few weeks after resection of an angiosarcoma of the small intestine, disclosing a primary angiosarcoma of the aortic wall with metastatic disease.
  • [MeSH-major] Aorta, Thoracic. Aortic Diseases / diagnosis. Hemangiosarcoma / diagnosis. Mesenteric Artery, Superior. Mesenteric Vascular Occlusion / etiology. Thrombosis / etiology. Vascular Neoplasms / diagnosis
  • [MeSH-minor] Aged. Aortography. Combined Modality Therapy. Diagnosis, Differential. Female. Humans. Ileal Neoplasms / diagnosis. Ileal Neoplasms / pathology. Ileal Neoplasms / secondary. Ileal Neoplasms / therapy. Image Processing, Computer-Assisted. Imaging, Three-Dimensional. Jejunal Neoplasms / diagnosis. Jejunal Neoplasms / pathology. Jejunal Neoplasms / secondary. Jejunal Neoplasms / therapy. Palliative Care. Tomography, X-Ray Computed

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  • (PMID = 17323296.001).
  • [ISSN] 0301-1526
  • [Journal-full-title] VASA. Zeitschrift für Gefässkrankheiten
  • [ISO-abbreviation] VASA
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 34
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45. Fodor J, Orosz Z, Szabó E, Sulyok Z, Polgár C, Zaka Z, Major T: Angiosarcoma after conservation treatment for breast carcinoma: our experience and a review of the literature. J Am Acad Dermatol; 2006 Mar;54(3):499-504
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma after conservation treatment for breast carcinoma: our experience and a review of the literature.
  • The development of angiosarcoma of the breast is a recognized complication of breast conservation therapy (BCT), but the evolution, prevalence, and outcome have not been accurately established.
  • We sought to evaluate and review the clinicopathologic, prognostic, and treatment attributes of angiosarcoma arising in the irradiated breast after BCT.
  • We conducted a retrospective chart and slide review of 8 patients seen between 1996 and 2004 with a diagnosis of secondary angiosarcoma.
  • The mean age of the patients at onset of the breast cancer and angiosarcoma was 65 and 72 years, respectively.
  • The mean latency period between the treatment of the breast cancer and the diagnosis of angiosarcoma was 75 months.
  • The estimated incidence of angiosarcoma after BCT was found to be 0.14 %.
  • BCT-associated angiosarcoma arises after a relatively brief interval, and breast edema-fibrosis can possibly contribute to its development.
  • As shown by a review of the literature, angiosarcomas are often resistant to surgery, chemotherapy, and radiotherapy, and targeted therapy against tumor biological properties may be a new approach to angiosarcoma treatment.
  • [MeSH-major] Breast Neoplasms / etiology. Breast Neoplasms / therapy. Hemangiosarcoma / etiology. Neoplasms, Second Primary / etiology

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  • (PMID = 16488303.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 41
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46. Delacruz V, Jorda M, Gomez-Fernandez C, Benedetto P, Ganjei P: Fine-needle aspiration diagnosis of angiosarcoma of the spleen: a case report and review of the literature. Arch Pathol Lab Med; 2005 Aug;129(8):1054-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fine-needle aspiration diagnosis of angiosarcoma of the spleen: a case report and review of the literature.
  • Primary angiosarcoma of the spleen is a very rare neoplasm with a poor prognosis.
  • The definitive diagnosis is usually based on the histologic evaluation of the splenectomy specimen.
  • We describe a case of angiosarcoma diagnosed by fine-needle aspiration cytology prior to splenectomy.
  • A malignant endothelial neoplasm was diagnosed by fine-needle aspiration cytology using immunocytochemistry, and a splenectomy confirmed the presence of angiosarcoma.
  • To our knowledge, this is the first well-documented and confirmed case of primary angiosarcoma of the spleen diagnosed by fine-needle aspiration cytology.
  • [MeSH-major] Biopsy, Fine-Needle. Hemangiosarcoma / secondary. Splenic Neoplasms / pathology

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  • (PMID = 16048401.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Biomarkers, Tumor; 9001-27-8 / Factor VIII
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47. Styring E, Fernebro J, Jönsson PE, Ehinger A, Engellau J, Rissler P, Rydholm A, Nilbert M, Vult von Steyern F: Changing clinical presentation of angiosarcomas after breast cancer: from late tumors in edematous arms to earlier tumors on the thoracic wall. Breast Cancer Res Treat; 2010 Aug;122(3):883-7
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  • [Title] Changing clinical presentation of angiosarcomas after breast cancer: from late tumors in edematous arms to earlier tumors on the thoracic wall.
  • Angiosarcoma is a rare complication of breast cancer treatment.
  • In order to define predictors, clinical presentation, and outcome, we characterized a population-based 50-year cohort of angiosarcomas after breast cancer.
  • Clinical data were collected from all females with previous breast cancer who developed angiosarcomas/lymphangiosarcomas on the thoracic wall/upper extremity between 1958 and 2008 in the Southern Swedish health care region.
  • In total, 31 angiosarcomas developed at a median age of 71 years.
  • The patients formed two distinct groups; 14 females treated for breast cancer with radical mastectomy and radiotherapy 1949-1988 developed angiosarcomas in edematous arms (Stewart-Treves syndrome) after median 11 years, and 17 females treated by segmental resection, anti-hormonal treatment and radiotherapy 1980-2005 developed angiosarcomas in the irradiated field on the thoracic wall after median 7.3 years.
  • In this population-based cohort, the early angiosarcomas developed in edematous arms after radical mastectomies, whereas more recent cases occurred after a shorter time period in the irradiated fields following breast conserving surgery.
  • We conclude that the clinical presentation of angiosarcomas has changed, parallel with altered treatment principles for breast cancer.
  • [MeSH-major] Arm. Breast Neoplasms / therapy. Edema / etiology. Hemangiosarcoma / etiology. Neoplasm Recurrence, Local / etiology. Neoplasms, Second Primary / etiology. Thoracic Wall / pathology

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  • (PMID = 20087653.001).
  • [ISSN] 1573-7217
  • [Journal-full-title] Breast cancer research and treatment
  • [ISO-abbreviation] Breast Cancer Res. Treat.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
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48. Abraham JA, Hornicek FJ, Kaufman AM, Harmon DC, Springfield DS, Raskin KA, Mankin HJ, Kirsch DG, Rosenberg AE, Nielsen GP, Desphpande V, Suit HD, DeLaney TF, Yoon SS: Treatment and outcome of 82 patients with angiosarcoma. Ann Surg Oncol; 2007 Jun;14(6):1953-67
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Treatment and outcome of 82 patients with angiosarcoma.
  • BACKGROUND: Angiosarcomas are an uncommon type of malignancy that are generally thought to behave usually in a locally aggressive fashion; they often metastasize to distant sites.
  • METHODS: Patients with a diagnosis of angiosarcoma treated at our institution between 1980 and 2006 were analyzed for patient demographics, tumor characteristics, multimodality treatment, and outcomes.
  • RESULTS: A total of 82 patients were divided into those with primary and advanced disease.
  • Of 46 patients with primary disease, all patients underwent surgical resection, 67% received radiotherapy, and 27% received chemotherapy.
  • Five-year disease-specific survival was 60%, and negative prognostic factors included intermediate or high grade, and tumors arising in a radiated or lymphedema field.
  • Of 36 patients with advanced disease, 36% underwent a palliative operation, 78% received radiation, and 58% received chemotherapy.
  • CONCLUSIONS: Primary angiosarcomas treated with aggressive surgical resection and the addition of radiation for close margins or worrisome pathologic features can result in long-term survival in most patients.
  • Patients with advanced disease have a poor prognosis, but there can be dramatic responses to chemotherapy in a minority of patients.
  • [MeSH-major] Hemangiosarcoma / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Bone Neoplasms / pathology. Bone Neoplasms / surgery. Breast Neoplasms / pathology. Breast Neoplasms / surgery. Chemotherapy, Adjuvant. Disease-Free Survival. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoadjuvant Therapy. Neoplasm Staging. Neoplasms, Radiation-Induced / pathology. Neoplasms, Radiation-Induced / surgery. Palliative Care. Radiotherapy, Adjuvant. Retrospective Studies. Skin Neoplasms / pathology. Skin Neoplasms / surgery. Soft Tissue Neoplasms / pathology. Soft Tissue Neoplasms / surgery. Survival Rate. Treatment Outcome

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  • (PMID = 17356953.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / 5K12CA87723-03
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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49. Brenn T, Fletcher CD: Radiation-associated cutaneous atypical vascular lesions and angiosarcoma: clinicopathologic analysis of 42 cases. Am J Surg Pathol; 2005 Aug;29(8):983-96
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Radiation-associated cutaneous atypical vascular lesions and angiosarcoma: clinicopathologic analysis of 42 cases.
  • Cutaneous angiosarcoma is a rare but well-recognized complication after radiation therapy.
  • A total of 42 cases diagnosed as either radiation-associated cutaneous vascular lesions or angiosarcoma were retrieved from departmental and consultation files from 1995 to 2003.
  • Reasons for radiation included breast carcinoma (35 cases) and a variety of other lesions (mainly malignant disease).
  • Angiosarcomas presented as larger lesions (median, 7.5 cm) compared with AVLs (median, 0.5 cm).
  • The time interval from radiation was significantly shorter for the development of AVL (median, 3.5 years) compared with cutaneous angiosarcoma (median, 6 years).
  • Histologic evaluation revealed 26 lesions meeting criteria for angiosarcoma, ranging from morphologically low-grade to high-grade; 16 cases were classified as AVLs.
  • Some showed prominent hyperchromatic endothelial cells, while others were characterized by areas with a dissecting growth pattern within dermal collagen.
  • Endothelial multilayering was absent.
  • Clinical follow-up, available for 36 patients (range, 2-84 months; median, 17 months), revealed 4 patients who died of disease, 4 patients had systemic metastasis, and 12 patients with local recurrence.
  • All patients with systemic relapse had an initial diagnosis of angiosarcoma.
  • One patient with an AVL had a recurrence at the same site, 3 patients developed additional new lesions, and 1 patient developed multiple small papules on the chest wall, which progressed from an AVL to angiosarcoma.
  • This study outlines the morphologic spectrum of radiation-associated cutaneous AVLs.
  • [MeSH-major] Hemangiosarcoma / etiology. Hemangiosarcoma / pathology. Neoplasms, Radiation-Induced / pathology. Skin / blood supply. Skin / pathology. Skin Neoplasms / etiology. Skin Neoplasms / pathology

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  • (PMID = 16006792.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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50. Wohlsein P, Schöpper H, Kämmerling J, Wünsch U, Schulze C: [Primary cutaneous and metastasing haemangiosarcoma in an addax (Addax nasomaculatus)]. Dtsch Tierarztl Wochenschr; 2008 Jan;115(1):20-5
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  • [Title] [Primary cutaneous and metastasing haemangiosarcoma in an addax (Addax nasomaculatus)].
  • In this communication clinical signs, morphological and immunohistological findings in a 15-year-old, female addax with a primary cutaneous, re-occurring and metastasing haemangiosarcoma of a forelimb are reported.
  • [MeSH-major] Antelopes. Hemangiosarcoma / veterinary. Lung Neoplasms / veterinary. Skin Neoplasms / veterinary

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  • (PMID = 18265754.001).
  • [ISSN] 0341-6593
  • [Journal-full-title] DTW. Deutsche tierärztliche Wochenschrift
  • [ISO-abbreviation] DTW. Dtsch. Tierarztl. Wochenschr.
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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51. Granier G, Lemoine MC, Mares P, Pignodel C, Marty-Double C: [Primary angiosarcoma of the male breast]. Ann Pathol; 2005 Jun;25(3):235-9
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  • [Title] [Primary angiosarcoma of the male breast].
  • [Transliterated title] Angiosarcome primitif du sein chez l'homme.
  • We report an exceptional case of primary breast angiosarcoma in a 58-year-old man.
  • Diagnosis should be established as early as possible because the 10-year overall survival rate is 80% for low grade tumors and only 20% for high grade tumors.
  • [MeSH-major] Breast Neoplasms / pathology. Hemangiosarcoma / pathology

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  • (PMID = 16230950.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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52. Itakura E, Yamamoto H, Oda Y, Tsuneyoshi M: Detection and characterization of vascular endothelial growth factors and their receptors in a series of angiosarcomas. J Surg Oncol; 2008 Jan 1;97(1):74-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Detection and characterization of vascular endothelial growth factors and their receptors in a series of angiosarcomas.
  • BACKGROUND: Angiosarcomas are malignant mesenchymal neoplasms, including sarcomas of presumptive vascular endothelial origin and sarcomas of probable lymphatic origin.
  • The majority of angiosarcomas are thought to originate from vascular endothelia and spread via bloodstream to lung, but lymphatic metastases can occur.
  • METHODS: We investigated immunohistochemical expression of vascular endothelial growth factors (VEGF-A, VEGF-C) and their receptors (VEGFR-1, VEGFR-2, VEGFR-3) in a series of 34 angiosarcomas.
  • CONCLUSIONS: VEGF-A and VEGFR-1 were detected in diverse subtypes of angiosarcomas.
  • In cooperation, VEGF-A and VEGF-C are likely to be involved in the development of angiosarcoma associated with lymphedema.
  • Angiosarcoma of the scalp, which is traditionally considered as a true hemangiosarcoma, may include some cases of lymphatic origin.
  • [MeSH-major] Hemangiosarcoma / chemistry. Receptors, Vascular Endothelial Growth Factor / analysis. Vascular Endothelial Growth Factor A / analysis

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  • [Copyright] (c) 2007 Wiley-Liss, Inc.
  • (PMID = 18041747.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Vascular Endothelial Growth Factor A; EC 2.7.10.1 / Receptors, Vascular Endothelial Growth Factor
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53. Deyrup AT, McKenney JK, Tighiouart M, Folpe AL, Weiss SW: Sporadic cutaneous angiosarcomas: a proposal for risk stratification based on 69 cases. Am J Surg Pathol; 2008 Jan;32(1):72-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sporadic cutaneous angiosarcomas: a proposal for risk stratification based on 69 cases.
  • Angiosarcomas have traditionally been considered high-grade lesions for which histologic features and grading have played no role in prognostication and, consequently, they have been excluded from the American Joint Committee on Cancer staging system.
  • We have, therefore, analyzed 69 cutaneous angiosarcomas seen in consultation and not associated with lymphedema or prior radiation therapy to determine if a combination of histologic and clinical parameters could be used to differentiate indolent from aggressive tumors.
  • Forty-seven patients died (30 of disease) and 22 were alive at last known follow-up (range, 16 to 158 mo; mean, 65; median, 36).
  • Five-year disease-specific survival was 48%.
  • In conclusion, we report that a combination of clinical and histologic features allows stratification of angiosarcoma patients into 2 risk groups that are strongly associated with marked differences in clinical course.
  • [MeSH-major] Hemangiosarcoma / pathology. Skin Neoplasms / pathology

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  • (PMID = 18162773.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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54. Hirotsune N, Terada K, Meguro T, Nishino S, Asano T, Manabe T, Toi Y: [Superselective feeder embolization for hemorrhage from cutaneous angiosarcoma in scalp]. No Shinkei Geka; 2005 Oct;33(10):995-9
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  • [Title] [Superselective feeder embolization for hemorrhage from cutaneous angiosarcoma in scalp].
  • The diagnosis of angiosarcoma was confirmed histologically.
  • The early diagnosis by neurosurgeon may lead to improved survival.
  • [MeSH-major] Embolization, Therapeutic / methods. Hemangiosarcoma / complications. Hemorrhage / therapy. Scalp. Skin Neoplasms / complications

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  • (PMID = 16223178.001).
  • [ISSN] 0301-2603
  • [Journal-full-title] No shinkei geka. Neurological surgery
  • [ISO-abbreviation] No Shinkei Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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55. Tokuyama W, Mikami T, Masuzawa M, Okayasu I: Autocrine and paracrine roles of VEGF/VEGFR-2 and VEGF-C/VEGFR-3 signaling in angiosarcomas of the scalp and face. Hum Pathol; 2010 Mar;41(3):407-14
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  • [Title] Autocrine and paracrine roles of VEGF/VEGFR-2 and VEGF-C/VEGFR-3 signaling in angiosarcomas of the scalp and face.
  • Angiosarcoma of the skin is an extremely rare malignant tumor of vascular origin that usually arises in the scalp and face of elderly persons.
  • To clarify its characteristic features and cell cycle kinetics, we quantitatively evaluated the expression of cell cycle-related molecules and vascular endothelial growth factors using immunohistochemical staining, for comparison with 2 benign vascular tumors of the skin, the capillary hemangioma and the cavernous hemangioma.
  • Cell proliferation, determined with reference to the Ki-67 labeling index, was highest in angiosarcomas and lowest in cavernous hemangiomas (angiosarcomas versus capillary hemangioma, P = .014; capillary hemangioma versus cavernous hemangiomas, P = 1.4 x 10(-4)).
  • Expressions of cyclin D1 and p16(INK4A) were also significantly higher in angiosarcoma than in cavernous hemangioma.
  • Expression levels of vascular endothelial growth factor and its receptor, VEGFR-2, were highest in angiosarcomas.
  • VEGF-C expression in angiosarcomas was significantly higher than in cavernous hemangiomas, and its receptor VEGFR-3 expression was highest in angiosarcomas.
  • [MeSH-major] Head and Neck Neoplasms / metabolism. Hemangiosarcoma / metabolism. Scalp / metabolism. Vascular Endothelial Growth Factor A / metabolism. Vascular Endothelial Growth Factor C / metabolism. Vascular Endothelial Growth Factor Receptor-2 / metabolism. Vascular Endothelial Growth Factor Receptor-3 / metabolism

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 19913279.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclin A; 0 / Cyclin E; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Ki-67 Antigen; 0 / Vascular Endothelial Growth Factor A; 0 / Vascular Endothelial Growth Factor C; EC 2.7.10.1 / Vascular Endothelial Growth Factor Receptor-2; EC 2.7.10.1 / Vascular Endothelial Growth Factor Receptor-3
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56. Teltzrow T, Hallermann C, Müller S, Schwipper V: [Foreign body-induced angiosarcoma 60 years after a shell splinter injury]. Mund Kiefer Gesichtschir; 2006 Nov;10(6):415-8
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  • [Title] [Foreign body-induced angiosarcoma 60 years after a shell splinter injury].
  • [Transliterated title] Fremdkörperinduziertes Angiosarkom 60 Jahre nach Granatsplitterverletzung.
  • An 84-year-old gentleman developed an angiosarcoma in the lateral temporal fossa 60 years after a World War II injury.
  • [MeSH-major] Blast Injuries / pathology. Foreign Bodies / pathology. Foreign-Body Reaction / pathology. Hemangiosarcoma / pathology. Maxillary Sinus / injuries. Maxillary Sinus Neoplasms / pathology. Metals

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  • (PMID = 17006674.001).
  • [ISSN] 1432-9417
  • [Journal-full-title] Mund-, Kiefer- und Gesichtschirurgie : MKG
  • [ISO-abbreviation] Mund Kiefer Gesichtschir
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Metals
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57. Schlemmer M, Reichardt P, Verweij J, Hartmann JT, Judson I, Thyss A, Hogendoorn PC, Marreaud S, Van Glabbeke M, Blay JY: Paclitaxel in patients with advanced angiosarcomas of soft tissue: a retrospective study of the EORTC soft tissue and bone sarcoma group. Eur J Cancer; 2008 Nov;44(16):2433-6
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  • [Title] Paclitaxel in patients with advanced angiosarcomas of soft tissue: a retrospective study of the EORTC soft tissue and bone sarcoma group.
  • RATIONALE: Angiosarcomas of soft tissue represent a heterogenous group of rare sarcomas with specific clinical behaviour and risk factors.
  • Paclitaxel appears to induce tumour control in a higher proportion of patients with angiosarcoma, as compared to other sarcomas.
  • METHOD: Clinical data from patients with angiosarcomas of soft tissue treated with single agent paclitaxel were collected from the centres of the soft tissue and bone sarcoma group of EORTC, using a standardised data collection form.
  • Primary angiosarcomas were located in scalp and face in 8 patients (25%) and at other primary sites in 24 patients (75%).
  • Eleven (34%) patients had been irradiated before as treatment for angiosarcoma.
  • In 8 (25%) patients, the angiosarcoma occurred at sites of prior radiation therapy for other malignancies.
  • The response rate was 62% (21/32) in the whole series, 75% (6/8) in scalp angiosarcomas and 58% (14/24) in other primary sites.
  • For the face/scalp group it was 9.5 months, and for patients with angiosarcomas at other sites it was 7.0 months, respectively.
  • CONCLUSION: Paclitaxel was found to be an active agent in angiosarcoma of soft tissue in this retrospective analysis.
  • [MeSH-major] Antineoplastic Agents, Phytogenic / therapeutic use. Hemangiosarcoma / drug therapy. Paclitaxel / therapeutic use. Soft Tissue Neoplasms / drug therapy


58. Scow JS, Reynolds CA, Degnim AC, Petersen IA, Jakub JW, Boughey JC: Primary and secondary angiosarcoma of the breast: the Mayo Clinic experience. J Surg Oncol; 2010 Apr 1;101(5):401-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary and secondary angiosarcoma of the breast: the Mayo Clinic experience.
  • BACKGROUND AND OBJECTIVES: Angiosarcoma of the breast can be divided into primary and secondary.
  • The objective was to determine clinicopathologic factors associated with breast angiosarcoma and to compare primary versus secondary angiosarcoma.
  • METHODS: Breast angiosarcoma cases at Mayo Clinic from 1960 to 2008 were identified.
  • Characteristics of primary and secondary angiosarcoma were compared.
  • RESULTS: Twenty-seven cases of primary angiosarcoma and 14 cases of secondary angiosarcoma were identified.
  • The median age of primary angiosarcoma patients was lower than that of secondary angiosarcoma--43 years versus 73 years (P < 0.0001).
  • Primary angiosarcoma more frequently presented with a mass, whereas secondary angiosarcoma presented with a rash (P < 0.0001).
  • Median time from radiation to secondary angiosarcoma diagnosis was 6.8 years.
  • Median tumor size was 7.0 cm for primary angiosarcoma and 5.0 cm for secondary angiosarcoma (P = 0.7).
  • Tumors were high grade in 33% of primary angiosarcoma and 82% of secondary angiosarcoma (P = 0.02).
  • Five-year survival for primary and secondary angiosarcoma was 46% and 69%, respectively (P = 0.8).
  • CONCLUSION: Primary angiosarcoma occurs in younger patients than secondary and more frequently presents with a mass.
  • Mastectomy is the mainstay of treatment for breast angiosarcoma.
  • Breast angiosarcoma is a rare malignancy with poor long-term prognosis.
  • [MeSH-major] Breast Neoplasms / pathology. Hemangiosarcoma / pathology. Neoplasms, Second Primary / pathology

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  • [Copyright] (c) 2010 Wiley-Liss, Inc.
  • (PMID = 20119983.001).
  • [ISSN] 1096-9098
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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59. Rozen WM, Mann GB: Angiosarcoma arising in an unirradiated breast with subsequent pituitary metastasis. Clin Breast Cancer; 2007 Oct;7(10):811-3
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  • [Title] Angiosarcoma arising in an unirradiated breast with subsequent pituitary metastasis.
  • Angiosarcoma of the breast is a rare condition with known risk factors.
  • The Stewart-Treves syndrome describes angiosarcoma of the arm or breast in the setting of adjuvant radiation therapy (RT) after breast conservation surgery.
  • Angiosarcoma of the breast, in the absence of RT, is rarer still.
  • We present a unique case of angiosarcoma of the breast, diagnosed 6 years after conservative surgery for carcinoma of the breast when no adjuvant RT was given.
  • Chronic postoperative lymphoedema in the breast delayed the investigation of skin changes, with an eventual diagnosis of angiosarcoma.
  • An isolated pituitary metastasis 9 months from the diagnosis, the first such reported case, adds to the complexity of the case.
  • The diagnosis and management of angiosarcoma of the breast is discussed.
  • Angiosarcoma is a rare occurrence after breast conservative surgery.
  • Postoperative lymphoedema can impede early diagnosis.
  • The disease can display unique metastatic potential.
  • [MeSH-major] Breast Neoplasms / pathology. Hemangiosarcoma / secondary. Neoplasms, Second Primary / pathology. Pituitary Neoplasms / secondary

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  • (PMID = 18021485.001).
  • [ISSN] 1526-8209
  • [Journal-full-title] Clinical breast cancer
  • [ISO-abbreviation] Clin. Breast Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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60. Nayar S, Nayar PG, Cherian K: Angiosarcoma presenting as syncope. Asian Cardiovasc Thorac Ann; 2008 Apr;16(2):154-6
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  • [Title] Angiosarcoma presenting as syncope.
  • Histopathology revealed a high grade angiosarcoma.
  • After three months the patient had extensive metastasis and succumbed to the disease.
  • This case report highlights the clinical presentation, rapid and aggressive course of cardiac angiosarcomas.
  • [MeSH-major] Heart Neoplasms / complications. Hemangiosarcoma / complications. Syncope / etiology

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  • (PMID = 18381877.001).
  • [ISSN] 1816-5370
  • [Journal-full-title] Asian cardiovascular & thoracic annals
  • [ISO-abbreviation] Asian Cardiovasc Thorac Ann
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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61. Glazebrook KN, Magut MJ, Reynolds C: Angiosarcoma of the breast. AJR Am J Roentgenol; 2008 Feb;190(2):533-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma of the breast.
  • OBJECTIVE: This article describes the imaging findings, pathologic correlation, and clinical presentation of rare primary and secondary angiosarcomas of the breast.
  • CONCLUSION: With the increasing use of breast conservation therapy for breast cancer, reports of postirradiation angiosarcoma have increased.
  • Both primary and secondary angiosarcomas may present with bruiselike skin discoloration, which may delay the diagnosis.
  • [MeSH-major] Breast Neoplasms / diagnosis. Diagnostic Imaging / methods. Hemangiosarcoma / diagnosis. Image Enhancement / methods

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  • (PMID = 18212243.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 18
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62. Fayette J, Martin E, Piperno-Neumann S, Le Cesne A, Robert C, Bonvalot S, Ranchère D, Pouillart P, Coindre JM, Blay JY: Angiosarcomas, a heterogeneous group of sarcomas with specific behavior depending on primary site: a retrospective study of 161 cases. Ann Oncol; 2007 Dec;18(12):2030-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcomas, a heterogeneous group of sarcomas with specific behavior depending on primary site: a retrospective study of 161 cases.
  • BACKGROUND: Angiosarcomas are rare, heterogeneous and a retrospective study was conducted to describe their natural history.
  • PATIENTS AND METHODS: We reviewed 161 files of angiosarcoma treated in three institutions of the French Sarcoma Group from 1980 to 2004.
  • At initial diagnosis, 31 (19%) had metastases.
  • With an average time since initial diagnosis of 8.1 years, 123 (76%) patients progressed and 76 (47%) died.
  • In multivariate analysis, liver primary site [relative risk (RR) = 12.62], performance status (PS) of two or more (RR = 3.83), presence of metastases at diagnosis (RR = 2.50), soft tissue tumor (RR = 0.31) were correlated to OS.
  • CONCLUSIONS: Angiosarcomas have an overall poor outcome, but with a clearly distinct prognosis depending on the primary site.

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  • (PMID = 17974557.001).
  • [ISSN] 1569-8041
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] England
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63. Kardum-Skelin I, Jelić-Puskarić B, Pazur M, Vidić-Paulisić I, Jakić-Razumović J, Separović V: A case report of breast angiosarcoma. Coll Antropol; 2010 Jun;34(2):645-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case report of breast angiosarcoma.
  • Angiosarcoma is a rare disease of the breast with the reported incidence of only 0.04% of all breast malignancies.
  • The etiology of angiosarcoma remains unknown.
  • We present a patient with angiosarcoma which developed 12 years of the diagnosis of breast carcinoma and 8 years of the operative procedure and radiotherapy for disease recurrence.
  • A small angiomatous lesion of a few mm in size, cytologically suspect of vascular tumor (hemangioma or hemangiopericytoma) and histopathologically verified to be an atypical vascular lesion, was detected two years before breast enlargement and cytologic and histologic diagnosis of angiosarcoma.
  • The patient died 15 months of the diagnosis of angiosarcoma, after two tumor recurrences and intrathoracic cavity invasion.
  • [MeSH-major] Breast Neoplasms / pathology. Hemangiosarcoma / pathology

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  • (PMID = 20698145.001).
  • [ISSN] 0350-6134
  • [Journal-full-title] Collegium antropologicum
  • [ISO-abbreviation] Coll Antropol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
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64. Hanasono MM, Osborne MP, Dielubanza EJ, Peters SB, Gayle LB: Radiation-induced angiosarcoma after mastectomy and TRAM flap breast reconstruction. Ann Plast Surg; 2005 Feb;54(2):211-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Radiation-induced angiosarcoma after mastectomy and TRAM flap breast reconstruction.
  • Radiation-induced angiosarcoma of the breast is being reported with increasing frequency as a result of the increased use of radiation therapy in conjunction with breast conservation surgery.
  • The authors present a case of angiosarcoma occurring in a patient 6 years after undergoing mastectomy for invasive duct carcinoma with immediate transverse rectus abdominis musculocutaneous flap reconstruction followed by postoperative radiation therapy.
  • The diagnosis of angiosarcoma was made by skin biopsy performed by the patient's reconstructive surgeon on routine follow-up examination.
  • This is the first reported case of postradiation angiosarcoma occurring in a postmastectomy breast reconstructed with autogenous tissue and it is unusual in that the cancer invaded the musculocutaneous flap.
  • Diagnosis and management recommendations for radiation-induced angiosarcoma are discussed.
  • [MeSH-major] Breast Neoplasms / surgery. Carcinoma, Ductal, Breast / surgery. Hemangiosarcoma / etiology. Mastectomy, Modified Radical. Neoplasms, Radiation-Induced / surgery

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  • (PMID = 15655476.001).
  • [ISSN] 0148-7043
  • [Journal-full-title] Annals of plastic surgery
  • [ISO-abbreviation] Ann Plast Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ki-67 Antigen
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65. Azimi NA, Selter JG, Abott JD, Cabin HS, Hutner A, Copel J, Setaro JF: Angiosarcoma in a pregnant woman presenting with pericardial tamponade--a case report and review of the literature. Angiology; 2006 Mar-Apr;57(2):251-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma in a pregnant woman presenting with pericardial tamponade--a case report and review of the literature.
  • The authors present a rare case of pericardial tamponade complicating pregnancy with resulting diagnosis of angiosarcoma.
  • They review the literature involving pericardial disease in pregnancy and discuss important issues in management and include a discussion of angiosarcoma.
  • [MeSH-major] Cardiac Tamponade / etiology. Heart Neoplasms / complications. Hemangiosarcoma / complications. Pregnancy Complications, Neoplastic
  • [MeSH-minor] Adult. Biopsy. Cardiac Surgical Procedures / methods. Diagnosis, Differential. Echocardiography. Female. Follow-Up Studies. Heart Atria. Humans. Magnetic Resonance Imaging. Pericardial Effusion / complications. Pericardial Effusion / diagnosis. Pericardial Effusion / surgery. Pregnancy. Tomography, X-Ray Computed

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  • (PMID = 16518537.001).
  • [ISSN] 0003-3197
  • [Journal-full-title] Angiology
  • [ISO-abbreviation] Angiology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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66. Sher T, Hennessy BT, Valero V, Broglio K, Woodward WA, Trent J, Hunt KK, Hortobagyi GN, Gonzalez-Angulo AM: Primary angiosarcomas of the breast. Cancer; 2007 Jul 1;110(1):173-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary angiosarcomas of the breast.
  • BACKGROUND: The purpose of the study was to describe the clinicopathologic characteristics and clinical outcomes of patients with primary breast angiosarcoma.
  • METHODS: The institutional database was searched to identify breast angiosarcoma patients seen between 1965 and 2002.
  • Median tumor size at diagnosis was 5.5 cm.
  • CONCLUSIONS: Breast angiosarcoma is frequently advanced at diagnosis and has a tendency for local-regional recurrence.
  • [MeSH-major] Breast Neoplasms / pathology. Hemangiosarcoma / pathology

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  • [Copyright] Copyright (c) 2007 American Cancer Society.
  • (PMID = 17541936.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / L30 CA123630; United States / NCI NIH HHS / CA / L30 CA123630-01; United States / NCI NIH HHS / CA / L30 CA123630-02
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Estrogen; 0 / Receptors, Progesterone
  • [Other-IDs] NLM/ NIHMS283619; NLM/ PMC4329779
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67. Kahraman A, Miller M, Baba H, Gerken G, Hilgard P: [Angiosarcoma of the liver as a rare cause of rapidly progressive liver failure]. Med Klin (Munich); 2006 Sep 15;101(9):746-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Angiosarcoma of the liver as a rare cause of rapidly progressive liver failure].
  • [Transliterated title] Angiosarkom der Leber als seltene Ursache eines rasch progredienten Leberversagens.
  • BACKGROUND: Angiosarcoma of the liver is a rare, highly malignant and sometimes diffusely infiltrating vessel tumor with rapid progression and poor prognosis.
  • The patient was referred to the authors' center for evaluation of liver transplantation, but a massive weight loss despite long absence of any alcohol intake raised the suspicion of a malignant disease.
  • A following MRI demonstrated diffuse focal contrast enhancement in the entire liver parenchyma, confirming diffuse infiltration of the organ by a malignant tumor.
  • Sonographically guided percutaneous liver biopsy established the diagnosis of a malignant vascular tumor with diffuse infiltration of the liver parenchyma.
  • Therefore, the differential diagnosis of a peliosis hepatis was raised.
  • However, histology confirmed the diagnosis of a malignant angiosarcoma with diffuse osseous metastases.
  • CONCLUSION: A diffuse infiltration of the liver by an angiosarcoma in the absence of any definite lesions may lead to a substantial delay of the diagnosis.
  • The only relevant differential diagnosis in this case is the equally rare peliosis hepatis.
  • [MeSH-major] Hemangiosarcoma / diagnosis. Liver Failure / etiology. Liver Neoplasms / diagnosis
  • [MeSH-minor] Biopsy. Bone Neoplasms / diagnosis. Bone Neoplasms / pathology. Bone Neoplasms / secondary. Diagnosis, Differential. Disease Progression. Esophageal and Gastric Varices / pathology. Fatal Outcome. Gastrointestinal Hemorrhage / pathology. Humans. Liver / pathology. Liver Cirrhosis, Alcoholic / diagnosis. Liver Cirrhosis, Alcoholic / pathology. Magnetic Resonance Imaging. Male. Middle Aged. Peliosis Hepatis / diagnosis. Peliosis Hepatis / pathology

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  • (PMID = 16977400.001).
  • [ISSN] 0723-5003
  • [Journal-full-title] Medizinische Klinik (Munich, Germany : 1983)
  • [ISO-abbreviation] Med. Klin. (Munich)
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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68. Verge J, Albiol J, Navas M, Martín C: [Primary angiosarcoma of the spleen with liver metastases. Case report and literature review]. Cir Esp; 2005 Jul;78(1):50-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Primary angiosarcoma of the spleen with liver metastases. Case report and literature review].
  • [Transliterated title] Angiosarcoma primario de bazo con metástasis hepáticas: presentación de un caso y revisión de la bibliografía.
  • Angiosarcomas of the spleen are infrequent tumors that often present with liver metastases.
  • Immunohistochemical markers can aid preoperative diagnosis since radiological and ultrasonographic images are fairly nonspecific.
  • [MeSH-major] Hemangiosarcoma / secondary. Hemangiosarcoma / surgery. Liver Neoplasms / secondary. Liver Neoplasms / surgery. Splenic Neoplasms / pathology. Splenic Neoplasms / surgery

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  • (PMID = 16420791.001).
  • [ISSN] 0009-739X
  • [Journal-full-title] Cirugía española
  • [ISO-abbreviation] Cir Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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69. Guode Z, Qi P, Hua G, Shangchen X, Hanbin W: Primary cerebellopontine angle angiosarcoma. J Clin Neurosci; 2008 Aug;15(8):942-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary cerebellopontine angle angiosarcoma.
  • Primary intracranial angiosarcomas are rare.
  • To our knowledge, no cerebellopontine (CP) angle angiosarcoma has been reported.
  • The preoperative diagnosis was neurogenic tumor with haemorrhage.
  • Histopathology and immunohistochemistry revealed an angiosarcoma.
  • This case report highlights that clinicians should be aware of the characteristics of angiosarcoma, and also stresses the need to include angiosarcoma in the differential diagnosis of rare lesions located in the CP angle.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Cerebellopontine Angle / pathology. Hemangiosarcoma / pathology

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  • (PMID = 18314334.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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70. Koch M, Nielsen GP, Yoon SS: Malignant tumors of blood vessels: angiosarcomas, hemangioendotheliomas, and hemangioperictyomas. J Surg Oncol; 2008 Mar 15;97(4):321-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant tumors of blood vessels: angiosarcomas, hemangioendotheliomas, and hemangioperictyomas.
  • Sarcomas that arise from or resemble the components of blood vessels are uncommon and include angiosarcomas, hemangioendotheliomas, and hemangiopericytomas.
  • This article reviews the management of these three types of sarcomas.
  • Diagnosis can sometimes be difficult, with the diagnosis of hemangiopericytoma versus solitary fibrous tumor currently in debate.
  • Each of these sarcomas subtypes has certain unique clinical traits.
  • For patients with advanced disease, various chemotherapeutic regimens may result in meaningful responses in a minority of patients.
  • [MeSH-major] Hemangioendothelioma / diagnosis. Hemangioendothelioma / therapy. Hemangiopericytoma / diagnosis. Hemangiopericytoma / therapy. Hemangiosarcoma / diagnosis. Hemangiosarcoma / therapy
  • [MeSH-minor] Chemotherapy, Adjuvant. Combined Modality Therapy. Humans. Neoplasms, Radiation-Induced. Prognosis. Radiotherapy / adverse effects. Skin Neoplasms / diagnosis. Skin Neoplasms / etiology. Skin Neoplasms / therapy

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 18286475.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 89
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71. Champeaux-Orange E, Bonneau C, Raharimanana B, Favre A, Ibrahim M, Breteau N: [Primary breast angiosarcoma: two case reports]. Cancer Radiother; 2009 Jun;13(3):209-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Primary breast angiosarcoma: two case reports].
  • [Transliterated title] Angiosarcome mammaire primitif: à propos de deux cas.
  • Primary angiosarcoma is a rare type of breast cancer, the diagnosis is difficult to establish and it has the worst prognostic of all breast malignancies.
  • Two cases of primary breast angiosarcoma have been observed at the centre Henry Kaplan of Tours and at the hospital La Source of Orleans since 2001.
  • [MeSH-major] Breast Neoplasms / pathology. Hemangiosarcoma / pathology

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  • (PMID = 19410492.001).
  • [ISSN] 1278-3218
  • [Journal-full-title] Cancer radiothérapie : journal de la Société française de radiothérapie oncologique
  • [ISO-abbreviation] Cancer Radiother
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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72. Terada T: Fatal poorly differentiated angiosarcoma of the scalp. Int J Clin Exp Pathol; 2010;3(5):541-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fatal poorly differentiated angiosarcoma of the scalp.
  • Cutaneous angiosarcoma is a very rare but aggressive tumor.
  • Angiosarcoma of the scalp is very rare, and a review of the world literature revealed less than 60 cases.
  • Here, the author reports a case of poorly differentiated angiosarcoma of the scalp.
  • The pathological diagnosis was very difficult.
  • The biopsy showed proliferation of malignant spindle cells in the dermis.
  • Intracytoplasmic vacuoles were recognized in the malignant tumor cells in some places.
  • Immunohistochemically, the malignant spindle cells were positive for factor VIII-related antigen (F-VIII-RA), Ulex lectin, CD31, CD34, vimentin, p53 protein.
  • The intracytoplasmic vacuoles were strongly positive for F-VIII-RA, Ulex lectin, CD31, and CD34, The abortive vasoformative channels were moderately positive for these endothelial markers.
  • A pathologic diagnosis of angiosarcoma of the scalp was made.
  • [MeSH-major] Hemangiosarcoma / pathology. Scalp / pathology. Skin Neoplasms / pathology

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  • [Cites] Cancer. 1987 Mar 1;59(5):1046-57 [3815265.001]
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  • (PMID = 20606736.001).
  • [ISSN] 1936-2625
  • [Journal-full-title] International journal of clinical and experimental pathology
  • [ISO-abbreviation] Int J Clin Exp Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC2897108
  • [Keywords] NOTNLM ; CD31 / CD34 / Cutaneous angiosarcoma / Ulex lectin / for factor VIII-related antigen (F-VIII-RA) / p53 protein / scalp / vimentin
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73. Saint-Blancard P, Hardy K, Bonnichon A, Jancovici R, Vaylet F, Margery J: [Three-year survival after treatment of a primary pulmonary angiosarcoma]. Rev Pneumol Clin; 2007 Feb;63(1):55-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Three-year survival after treatment of a primary pulmonary angiosarcoma].
  • [Transliterated title] Trois ans de survie après traitement d'un angiosarcome pulmonaire primitif.
  • We report an observation of angiosarcoma of the pulmonary artery in a 65-year-old man hospitalized for acute dyspnea revealing a left mass hilaire which arose from the pulmonary artery before the development of obstructive endobronchial extension.
  • [MeSH-major] Hemangiosarcoma / therapy. Lung Neoplasms / therapy
  • [MeSH-minor] Aged. Antibiotics, Antineoplastic / administration & dosage. Antibiotics, Antineoplastic / therapeutic use. Antineoplastic Agents, Alkylating / administration & dosage. Antineoplastic Agents, Alkylating / therapeutic use. Chemotherapy, Adjuvant. Disease-Free Survival. Doxorubicin / administration & dosage. Doxorubicin / therapeutic use. Endoscopy. Follow-Up Studies. Humans. Ifosfamide / administration & dosage. Ifosfamide / therapeutic use. Immunohistochemistry. Lung / pathology. Male. Pneumonectomy. Positron-Emission Tomography. Radiography, Thoracic. Time Factors. Tomography, X-Ray Computed

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  • (PMID = 17457286.001).
  • [ISSN] 0761-8417
  • [Journal-full-title] Revue de pneumologie clinique
  • [ISO-abbreviation] Rev Pneumol Clin
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Antineoplastic Agents, Alkylating; 80168379AG / Doxorubicin; UM20QQM95Y / Ifosfamide
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74. Fujii Y, Koibuchi-Yamaoka H, Taniguchi N, Yasuda Y, Nagai H: Metastasis from a primary angiosarcoma of the scalp to the colon: sonographic and CT findings. J Clin Ultrasound; 2008 Feb;36(2):110-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastasis from a primary angiosarcoma of the scalp to the colon: sonographic and CT findings.
  • We report a case of metastasis to the colon from a primary angiosarcoma of the scalp in a 61-year-old Japanese man and describe the sonographic features and CT findings, with a brief discussion of the clinical and histopathologic findings.
  • Although this entity is extremely rare, it should be considered when a patient with prior diagnosis of angiosarcoma in another organ has focal thickening with preserved compressibility of the wall of the colon.
  • [MeSH-major] Colonic Neoplasms / secondary. Head and Neck Neoplasms / pathology. Hemangiosarcoma / secondary. Scalp. Skin Neoplasms / pathology. Tomography, X-Ray Computed / methods. Ultrasonography, Doppler / methods
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged

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  • [Copyright] (c) 2007 Wiley Periodicals, Inc.
  • (PMID = 17636504.001).
  • [ISSN] 0091-2751
  • [Journal-full-title] Journal of clinical ultrasound : JCU
  • [ISO-abbreviation] J Clin Ultrasound
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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75. Konishi Y, Sato H, Fujimoto T, Tanaka H, Takahashi O, Tanaka T: A case of primary uterine angiosarcoma: magnetic resonance imaging and computed tomography findings. Int J Gynecol Cancer; 2007 Jan-Feb;17(1):280-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of primary uterine angiosarcoma: magnetic resonance imaging and computed tomography findings.
  • Primary uterine angiosarcoma is exceedingly rare and has a poor prognosis.
  • Moreover, the radiologic findings of this disease have not been previously documented.
  • We present a case of a 62-year-old woman with primary uterine angiosarcoma who underwent abdominal hysterectomy and bilateral salpingo-oophorectomy.
  • Histologically, interlacing vascular spaces were lined by endothelial cells showing nuclear pleomorphism and mitotic activity.
  • Immunohistochemical staining was positive for the endothelial cell markers CD31, CD34, and Factor VIII, supporting the diagnosis of primary uterine angiosarcoma.
  • Radiologically, the most helpful sign in the characterization of uterine angiosarcoma is marked heterogeneity on T2-weighted MRI with focal areas of high signal intensity, known as the "cauliflower-like appearance."
  • In addition, findings of a strongly enhanced lesion on gadolinium-enhanced T1-weighted MRI and contrast-enhanced CT also support the diagnosis of angiosarcoma.
  • [MeSH-major] Hemangiosarcoma / diagnosis. Uterine Neoplasms / diagnosis

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  • (PMID = 17291268.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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76. van Geel AN, den Bakker MA: Bilateral angiosarcoma of the breast in a fourteen-year-old child. Rare Tumors; 2009;1(2):e38

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bilateral angiosarcoma of the breast in a fourteen-year-old child.
  • Malignant vascular tumors are rare and angiosarcomas of the breast in patients under 21 years of age are exceedingly uncommon.
  • In this report an angiosarcoma in the breast of a 14-year-old girl is described.
  • She died nine months after mastectomy with recurrent disease in the bones and the contralateral breast.
  • The etiology of most primary angiosarcomas is unknown.
  • Secondary angiosarcomas can develop after radiotherapy and chronic lymphedema.
  • The histology of this angiosarcoma is illustrated.

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  • (PMID = 21139917.001).
  • [ISSN] 2036-3613
  • [Journal-full-title] Rare tumors
  • [ISO-abbreviation] Rare Tumors
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2994455
  • [Keywords] NOTNLM ; angiosarcoma / breast. / infancy
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77. Tsolakis I, Lampropoulos G, Zolota V, Papadoulas S, Christeas N: Aortic angiosarcoma with cutaneous metastases. Vascular; 2009 May-Jun;17(3):176-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Aortic angiosarcoma with cutaneous metastases.
  • Primary aortic tumors are rare and include a variety of histologic types, including aortic angiosarcomas, with less than 100 cases being reported since the first description of these tumors in 1873.
  • The diagnosis of aortic angiosarcoma is usually confirmed by postoperative histopathologic examination or postmortem study.
  • We present a case of primary aortic angiosarcoma presenting with intermittent claudication and radiologic findings of aortoiliac atherosclerotic disease treated initially with stenting; lower extremity embolic skin metastases developed during follow-up that prompted resection of the aortic bifurcation and restoration of the arterial continuity with a bypass.
  • [MeSH-major] Aortic Diseases / diagnostic imaging. Foot Diseases / etiology. Hemangiosarcoma / diagnostic imaging. Skin Neoplasms / secondary

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  • (PMID = 19476753.001).
  • [ISSN] 1708-5381
  • [Journal-full-title] Vascular
  • [ISO-abbreviation] Vascular
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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78. Jobke B, Werner M, Jundt G, Ostertag H, Freyschmidt J: Protracted disseminated skeletal metastases from angiosarcoma of the spleen. Clin Exp Metastasis; 2010 Feb;27(2):117-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Protracted disseminated skeletal metastases from angiosarcoma of the spleen.
  • Angiosarcomas are high-grade vascular tumors associated with poor prognosis due to their aggressive nature.
  • The 55-years-old patient presented in this case report had a disease-free 4 years interval between splenectomy after primary angiosarcoma of the spleen and an unusual skeletal metastatic pattern mimicking benign angiomatosis.
  • Despite lacking radiographic evidence for a highly aggressive osseous process, the histopathological resemblance of the bone biopsy with the primary tumor manifestation and the fulminant course of disease after onset of disseminated osseous spread confirmed the malignant character of the vascular tumor.
  • [MeSH-major] Bone Neoplasms / secondary. Hemangiosarcoma / pathology. Splenic Neoplasms / pathology

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  • (PMID = 20174857.001).
  • [ISSN] 1573-7276
  • [Journal-full-title] Clinical & experimental metastasis
  • [ISO-abbreviation] Clin. Exp. Metastasis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 21
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79. Ishigami N, Horiba K: Primary cardiac angiosarcoma resection combined with right coronary artery bypass grafting. Jpn J Thorac Cardiovasc Surg; 2005 Nov;53(11):624-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary cardiac angiosarcoma resection combined with right coronary artery bypass grafting.
  • Diagnosis of a primary malignant tumor in the right atrium without distant metastasis was made by echocardiography, computed tomography and coronary angiography.
  • Final diagnosis was of angiosarcoma by pathological examination.
  • [MeSH-major] Coronary Artery Bypass / methods. Heart Neoplasms / surgery. Hemangiosarcoma / surgery

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  • (PMID = 16363724.001).
  • [ISSN] 1344-4964
  • [Journal-full-title] The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai zasshi
  • [ISO-abbreviation] Jpn. J. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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80. Sakurai H, Hada M, Miyashita Y, Tsukamoto K, Oyama T, Ashizawa I: Simultaneous bilateral spontaneous pneumothorax secondary to metastatic angiosarcoma of the scalp: report of a case. Surg Today; 2006;36(10):919-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Simultaneous bilateral spontaneous pneumothorax secondary to metastatic angiosarcoma of the scalp: report of a case.
  • Angiosarcoma is a highly malignant neoplasm, which most often develops on the scalp or face of elderly people.
  • We report a case of angiosarcoma manifesting as simultaneous bilateral spontaneous pneumothorax secondary to pulmonary metastases in an 86-year-old man.
  • The pneumothorax preceded the diagnosis of angiosarcoma.
  • This case suggests that a finding of simultaneous bilateral spontaneous pneumothorax may indicate a serious parenchymal lung disorder.
  • [MeSH-major] Head and Neck Neoplasms / complications. Hemangiosarcoma / complications. Lung Neoplasms / complications. Pneumothorax / etiology. Scalp. Skin Neoplasms / complications


81. Leung F, Terzibachian JJ, Gay C, Bourtembourg A, Sautière JL, Maillet R, Riethmuller D: [Radiation-induced breast angiosarcoma following breast-conserving therapy. Report of two cases]. Gynecol Obstet Fertil; 2010 Mar;38(3):214-6
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  • [Title] [Radiation-induced breast angiosarcoma following breast-conserving therapy. Report of two cases].
  • [Transliterated title] Angiosarcome mammaire radio-induit après traitement conservateur du cancer du sein. A propos de deux cas.
  • Breast angiosarcoma is a rare but serious complication of radiotherapy.
  • We report two cases of radiation-induced breast angiosarcoma in two patients having benefited from breast conserving surgery with radiation.
  • [MeSH-major] Breast Neoplasms / etiology. Hemangiosarcoma / etiology. Neoplasms, Radiation-Induced

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  • [Copyright] Copyright 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20153679.001).
  • [ISSN] 1769-6682
  • [Journal-full-title] Gynécologie, obstétrique & fertilité
  • [ISO-abbreviation] Gynecol Obstet Fertil
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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82. Arima-Iwasa S, Chijiiwa K, Makino I, Tanabe R, Ohuchida J, Kondo K: A case of hepatic angiosarcoma surviving for more than 16 months after hepatic resection. Hepatogastroenterology; 2007 Mar;54(74):533-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of hepatic angiosarcoma surviving for more than 16 months after hepatic resection.
  • Hepatic angiosarcoma is a non-epithelial malignant tumor and a rare primary neoplasm accounting for only a 0.1% of primary liver malignant tumors.
  • Hepatic angiosarcoma progresses rapidly; therefore, most cases are discovered at an advanced stage, and less than 20% of the patients have received surgery.
  • The lack of specific symptoms and radiological findings leads to the delay of diagnosis resulting in the poor prognosis.
  • To the best of our knowledge, only three patients have been reported to survive for more than one year after hepatic resection for angiosarcoma.
  • We herein report a patient with hepatic angiosarcoma, 4 cm in size, who underwent hepatic resection after confirming the diagnosis as angiosarcoma by the intraoperative frozen section examination.
  • [MeSH-major] Hemangiosarcoma / surgery. Hepatectomy. Liver Neoplasms / surgery
  • [MeSH-minor] Disease-Free Survival. Follow-Up Studies. Frozen Sections. Humans. Liver / pathology. Magnetic Resonance Imaging. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 17523315.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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83. Gherardi G, Rossi S, Perrone S, Scanni A: Angiosarcoma after breast-conserving therapy: fine-needle aspiration biopsy, immunocytochemistry, and clinicopathologic correlates. Cancer; 2005 Jun 25;105(3):145-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma after breast-conserving therapy: fine-needle aspiration biopsy, immunocytochemistry, and clinicopathologic correlates.
  • BACKGROUND: Angiosarcoma that arises after breast-conserving therapy can present clinically as a cutaneous and/or subcutaneous breast lump, which is misinterpreted easily as a recurrence of carcinoma.
  • To the authors' knowledge, the role of fine-needle aspiration (FNA) cytology in the early diagnosis of this life-threatening complication of breast carcinoma therapy has not been established fully.
  • METHODS: The authors studied three new patients with this type of secondary angiosarcoma diagnosed by FNA biopsy and immunocytochemistry, reviewed the literature on the topic, and examined relevant differential diagnostic issues.
  • Immunostaining of smears, however, provided conclusive evidence of the endothelial differentiation of tumor cells, and an FNA diagnosis of angiosarcoma was rendered in all patients.
  • The histopathology of all surgically excised tumors confirmed the diagnosis of high-grade angiosarcoma.
  • CONCLUSIONS: Based on the authors' experience, the FNA cytologic appearance of angiosarcoma that presented as a breast skin nodule in a breast carcinoma survivor easily could have been misinterpreted as carcinoma.
  • A correct diagnosis of this tumor relies on the proper evaluation of clinical findings and, as also shown by a review of the literature, requires immunocytochemical evidence of endothelial differentiation.
  • [MeSH-major] Biopsy, Fine-Needle. Breast Neoplasms / pathology. Breast Neoplasms / surgery. Hemangiosarcoma / secondary. Mastectomy, Segmental / adverse effects. Skin Neoplasms / secondary

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  • (PMID = 15844179.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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84. Costantini R, Di Bartolomeo N, Francomano F, Angelucci D, Innocenti P: Epithelioid angiosarcoma of the gallbladder: case report. J Gastrointest Surg; 2005 Jul-Aug;9(6):822-5
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  • [Title] Epithelioid angiosarcoma of the gallbladder: case report.
  • A patient with epithelioid angiosarcoma of the gallbladder is described.
  • Pathophysiological, clinical, and therapeutic aspects are discussed in relation to the available data on angiosarcomas of the gallbladder.
  • [MeSH-major] Cholecystectomy / methods. Gallbladder Neoplasms / pathology. Gallbladder Neoplasms / surgery. Hemangiosarcoma / secondary. Hemangiosarcoma / surgery. Liver Neoplasms / secondary

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  • (PMID = 15985238.001).
  • [ISSN] 1091-255X
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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85. Antonescu CR, Yoshida A, Guo T, Chang NE, Zhang L, Agaram NP, Qin LX, Brennan MF, Singer S, Maki RG: KDR activating mutations in human angiosarcomas are sensitive to specific kinase inhibitors. Cancer Res; 2009 Sep 15;69(18):7175-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] KDR activating mutations in human angiosarcomas are sensitive to specific kinase inhibitors.
  • Angiosarcomas (AS) represent a heterogeneous group of malignant vascular tumors occurring not only in different anatomic locations but also in distinct clinical settings, such as radiation or associated chronic lymphedema.
  • Although representing only 1% to 2% of soft tissue sarcomas, vascular sarcomas provide unique insight into the general process of tumor angiogenesis.
  • These data provide a basis for the activity of vascular endothelial growth factor receptor-directed therapy in the treatment of primary and radiation-induced AS.

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  • [Cites] Cancer. 1999 Nov 15;86(10):2034-7 [10570428.001]
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  • (PMID = 19723655.001).
  • [ISSN] 1538-7445
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA047179-15A29002; United States / NCI NIH HHS / CA / P01 CA047179; United States / NCI NIH HHS / CA / P01 CA047179-15A29002; United States / NCI NIH HHS / CA / P01CA47179
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / Vascular Endothelial Growth Factor Receptor-2
  • [Other-IDs] NLM/ NIHMS135278; NLM/ PMC2763376
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86. Braun U, Tschuor AC, Hilbe M, Lange CE, Schwarzwald C: [Ultrasonographic findings and treatment in a cow with a haemangiosarcoma of the urinary bladder]. Schweiz Arch Tierheilkd; 2009 Oct;151(10):490-4
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  • [Title] [Ultrasonographic findings and treatment in a cow with a haemangiosarcoma of the urinary bladder].
  • Histological examination of the mass revealed a haemangiosarcoma.
  • [MeSH-major] Cattle Diseases / surgery. Cattle Diseases / ultrasonography. Electrocoagulation / veterinary. Hemangiosarcoma / veterinary. Urinary Bladder Neoplasms / veterinary

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  • (PMID = 19780010.001).
  • [ISSN] 0036-7281
  • [Journal-full-title] Schweizer Archiv für Tierheilkunde
  • [ISO-abbreviation] Schweiz. Arch. Tierheilkd.
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Switzerland
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87. Souza FF, Katkar A, den Abbeele AD, Dipiro PJ: Breast angiosarcoma metastatic to the ovary. Case Rep Med; 2009;2009:381015
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Breast angiosarcoma metastatic to the ovary.
  • Primary angiosarcoma can arise anywhere in the body and when it arises in the breast, it usually affects women in their 3rd and 4th decades and accounts for one in 1700-2300 cases of primary breast cancer.
  • Although unusual, breast angiosarcomas tend to metastasize hematogenously rather than lymphogenously, have high rates of local recurrence, that often develop metastases soon after treatment, and have a dismal prognosis.
  • We present a case of a solitary ovarian metastasis from angiosarcoma of the breast.

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  • (PMID = 19718246.001).
  • [ISSN] 1687-9627
  • [Journal-full-title] Case reports in medicine
  • [ISO-abbreviation] Case Rep Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2729273
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88. Plotnik AN, Schweder P, Tsui A, Kavar B: Splenic angiosarcoma metastasis to the brain. J Clin Neurosci; 2008 Aug;15(8):927-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Splenic angiosarcoma metastasis to the brain.
  • Angiosarcoma is a rare primary non-haematolymphoid malignant neoplasm of the spleen.
  • This neoplastic process has a poor prognosis, with disease usually widespread by the time of presentation.
  • In the literature there has been only six case reports of cerebral metastasis from splenic angiosarcomas.
  • We report a 61-year-old woman who presented with a right occipital metastasis of a splenic angiosarcoma, 5 years after initial diagnosis, treated by stereotactic occipital craniotomy and resection of metastasis.
  • [MeSH-major] Brain Neoplasms / secondary. Hemangiosarcoma / pathology. Splenic Neoplasms / pathology

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  • (PMID = 18411053.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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89. Ozcelik C, Onat S, Yaldiz M, Ozcelik Z: Primary epithelioid angiosarcoma of the lung presenting as pulmonary hemorrhage. Asian Cardiovasc Thorac Ann; 2006 Feb;14(1):69-71
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  • [Title] Primary epithelioid angiosarcoma of the lung presenting as pulmonary hemorrhage.
  • Pulmonary angiosarcomas are usually secondary tumors, and only a few primary cases have been reported.
  • We report a unique case of epithelioid angiosarcoma presenting as a solitary mass in the right upper lobe with pulmonary hemorrhage.
  • Because of its epithelioid histology, this tumor may resemble a carcinoma or a variety of vascular lesions with epithelioid endothelial cells.
  • Therefore, the diagnosis of epithelioid angiosarcoma should be based on immunohistochemical staining.
  • [MeSH-major] Epithelioid Cells / pathology. Hemangiosarcoma / diagnosis. Hemorrhage / etiology. Lung Diseases / etiology. Lung Neoplasms / diagnosis
  • [MeSH-minor] Chest Pain / etiology. Cough / etiology. Diagnosis, Differential. Fatal Outcome. Hemoptysis / etiology. Humans. Immunohistochemistry. Lung / diagnostic imaging. Lung / pathology. Lung / surgery. Male. Middle Aged. Rare Diseases. Tomography, X-Ray Computed

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  • (PMID = 16432125.001).
  • [ISSN] 1816-5370
  • [Journal-full-title] Asian cardiovascular & thoracic annals
  • [ISO-abbreviation] Asian Cardiovasc Thorac Ann
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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90. Policarpio-Nicolas ML, Nicolas MM, Keh P, Laskin WB: Postradiation angiosarcoma of the small intestine: a case report and review of literature. Ann Diagn Pathol; 2006 Oct;10(5):301-5
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  • [Title] Postradiation angiosarcoma of the small intestine: a case report and review of literature.
  • Postradiation angiosarcoma is typically a high-grade sarcoma that presents mainly in the skin and superficial tissues.
  • Postradiation angiosarcoma arising in the small intestine is rare with only 11 cases documented in the English-language literature.
  • Herein, we report a postradiation angiosarcoma of the small intestine 9 years after radiotherapy for uterine cervical adenocarcinoma.
  • The diagnosis of angiosarcoma was confirmed immunohistochemically by tumor cell expression of CD31, CD34, and factor VIII-related antigen.
  • The diagnosis of PRA should be entertained for any poorly differentiated neoplasm arising in a previously irradiated site.
  • The correct diagnosis of PRA depends upon histomorphologic identification of vascular differentiation, coupled with immunohistochemical expression of endothelial-related markers.
  • [MeSH-major] Hemangiosarcoma / etiology. Intestinal Neoplasms / etiology. Intestine, Small. Neoplasms, Radiation-Induced / diagnosis

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  • (PMID = 16979525.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Antigens, CD34; 9001-27-8 / Factor VIII
  • [Number-of-references] 17
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91. Joo YT, Jeong CY, Jung EJ, Lee YJ, Hong SC, Choi SK, Park ST, Ha WS: Intra-abdominal angiosarcoma developing in a capsule of a foreign body: report of a case with associated hemorrhagic diathesis. World J Surg Oncol; 2005 Sep 14;3:60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intra-abdominal angiosarcoma developing in a capsule of a foreign body: report of a case with associated hemorrhagic diathesis.
  • BACKGROUND: Angiosarcoma occurs very rarely in the gastrointestinal tract and can present great diagnostic difficulty, especially when it is associated with intraabdominal abscess or granulation tissue.
  • CASE PRESENTATION: We report a case where the angiosarcoma was diagnosed after the occurrence of disseminated angiosarcoma and concurrent hemoperitoneum.
  • The tumor developed in the fibrous capsule of a foreign body, which was possibly related to the previous appendectomy twenty years ago, and became a widely disseminated malignant neoplasm in the abdomen.
  • Pathologic examination of the multiple intra-abdominal lesions showed the histological and immunohistological characteristics of the angiosarcoma.
  • CONCLUSION: Even though angiosarcoma in the gastrointestinal tract is extremely rare, when dealing with intraabdominal abscess or the gastrointestinal bleeding in patients who have undergone surgery or radiation therapy in the past, the possibility of angiosarcoma should be considered.
  • To make the definite diagnosis of angiosarcoma and to avoid the misdiagnosis of foreign body granuloma, thorough histological examination and immunohistochemical staining may be prerequisite.

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  • (PMID = 16159405.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1242259
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92. Mizrachi IB, Trobe JD, Deeb MG, Ramsburgh SR, Williams DM, Gebarski SS: Multiple brain infarcts and Balint syndrome in aortic arch angiosarcoma. J Neuroophthalmol; 2006 Jun;26(2):107-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multiple brain infarcts and Balint syndrome in aortic arch angiosarcoma.
  • The surgical specimen revealed angiosarcoma.
  • Of the few reported angiosarcomas involving the aorta, most have been located in the abdominal segment.
  • This is only the second reported case of aortic arch sarcoma presenting with stroke.
  • [MeSH-major] Agnosia / etiology. Aorta, Thoracic. Brain Infarction / etiology. Hemangiosarcoma / complications. Ocular Motility Disorders / etiology. Vascular Neoplasms / complications
  • [MeSH-minor] Diagnosis, Differential. Fatal Outcome. Female. Humans. Magnetic Resonance Imaging. Middle Aged. Syndrome. Tomography, X-Ray Computed

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  • (PMID = 16845310.001).
  • [ISSN] 1070-8022
  • [Journal-full-title] Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society
  • [ISO-abbreviation] J Neuroophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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93. Namysłowski G, Scierski W, Turecka L, Urbaniec N, Lange D: [A very rare case of low-grade angiosarcoma of the nose and paranasal sinuses]. Otolaryngol Pol; 2005;59(1):105-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A very rare case of low-grade angiosarcoma of the nose and paranasal sinuses].
  • Angiosarcomas of the nose and paranasal sinuses are extremely rare.
  • Histologically angiosarcomas are divided into two groups: low and high-grade.
  • We present a case of angiosarcoma of apparent low-grade malignancy localized within the nasal cavity and paranasal sinuses in a 74-year old woman treated by radiotherapy due to middle ear chemodectoma 21 years ago.
  • [MeSH-major] Hemangiosarcoma. Nose Neoplasms. Paranasal Sinus Neoplasms

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  • (PMID = 15915928.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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94. Moore A, Hendon A, Hester M, Samayoa L: Secondary angiosarcoma of the breast: can imaging findings aid in the diagnosis? Breast J; 2008 May-Jun;14(3):293-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Secondary angiosarcoma of the breast: can imaging findings aid in the diagnosis?
  • Secondary angiosarcomas, although rare, are aggressive tumors that can develop in breast tissue that has undergone prior radiation therapy.
  • We present three cases of secondary angiosarcoma of the breast in the setting of prior breast irradiation.
  • These imaging findings may enable the radiologist to suggest this diagnosis, even when the clinical presentation is more benign.
  • [MeSH-major] Breast Neoplasms / diagnosis. Hemangiosarcoma / diagnosis. Neoplasm Recurrence, Local / diagnosis. Neoplasms, Radiation-Induced / diagnosis

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  • (PMID = 18476885.001).
  • [ISSN] 1524-4741
  • [Journal-full-title] The breast journal
  • [ISO-abbreviation] Breast J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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95. Gonne E, Collignon J, Kurth W, Thiry A, Henry F, Jerusalem G, Gennigens C: [Angiosarcoma in chronic lymphoedema: a case of Stewart-Treves syndrome]. Rev Med Liege; 2009 Jul-Aug;64(7-8):409-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Angiosarcoma in chronic lymphoedema: a case of Stewart-Treves syndrome].
  • [Transliterated title] Angiosarcome sur lymphoedème chronique: un cas de syndrome de Stewart-Treves.
  • The Stewart-Treves Syndrome is defined as an angiosarcoma (very aggressive malignant tumor originating from endothelial cells) appearing in a specific clinical setting.
  • The diagnosis relies on medical history, clinical examination and a histological assesment (biopsy or resection).
  • [MeSH-major] Arm / pathology. Lymphangiosarcoma / diagnosis. Lymphedema / complications. Neoplasms, Second Primary / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 19777923.001).
  • [ISSN] 0370-629X
  • [Journal-full-title] Revue médicale de Liège
  • [ISO-abbreviation] Rev Med Liege
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Belgium
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96. Di Tommaso L, Colombo G, Miceli S, Ferrari B, Santoro A, Poletti A, Roncalli M: [Angiosarcoma of the nasal cavity. Report of a case and review of the literature]. Pathologica; 2007 Jun;99(3):76-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Angiosarcoma of the nasal cavity. Report of a case and review of the literature].
  • [Transliterated title] Angiosarcoma della cavità nasale. Descrizione di un caso e revisione della letteratura.
  • We report an unusual case of primary angiosarcoma of the nasal cavity (AS-nc).
  • Clinical--monolateral epistaxis in a young person--, radiological--polypoid hemorrhagic tumor arising within the nasal cavity and expanding into paranasal sinuses--, pathological--a network of anastomosing channels and solid areas immunoreactive for CD31 and CD34--and prognostic features--patient alive and well 36 months after the original diagnosis--are superimposable to those of previously reported AS-nc, suggesting that this lesion should be considered as a peculiar variant of classical AS.
  • [MeSH-major] Hemangiosarcoma / pathology. Nasal Cavity. Nose Neoplasms / pathology

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  • (PMID = 17987727.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 10
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97. West JG, Weitzel JN, Tao ML, Carpenter M, West JE, Fanning C: BRCA mutations and the risk of angiosarcoma after breast cancer treatment. Clin Breast Cancer; 2008 Dec;8(6):533-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] BRCA mutations and the risk of angiosarcoma after breast cancer treatment.
  • Post-breast cancer treatment-related angiosarcomas were first observed in lymphedematous extremities after mastectomy and are now being reported with increasing frequency after lumpectomy and radiation.
  • A case history is presented of a BRCA2 carrier who had a postmastectomy chest wall angiosarcoma but had neither therapeutic radiation nor clinically evident lymphedema.
  • The absence of established risk factors led to speculation that the BRCA2 germline mutation could be a causative factor in the development of this patient's angiosarcoma.
  • [MeSH-major] BRCA2 Protein / genetics. Breast Neoplasms / surgery. Carcinoma, Ductal, Breast / surgery. Germ-Line Mutation. Hemangiosarcoma / genetics. Neoplasms, Second Primary / genetics. Skin Neoplasms / genetics
  • [MeSH-minor] Adult. Female. Genetic Predisposition to Disease. Humans. Mastectomy. Neoplasm Recurrence, Local

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  • (PMID = 19073510.001).
  • [ISSN] 1526-8209
  • [Journal-full-title] Clinical breast cancer
  • [ISO-abbreviation] Clin. Breast Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / BRCA2 Protein
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98. Skubitz KM, Haddad PA: Paclitaxel and pegylated-liposomal doxorubicin are both active in angiosarcoma. Cancer; 2005 Jul 15;104(2):361-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Paclitaxel and pegylated-liposomal doxorubicin are both active in angiosarcoma.
  • BACKGROUND: Paclitaxel has unique activity in angiosarcomas of the face and scalp, but its activity in angiosarcomas originating at other sites is less well defined.
  • Paclitaxel and pegylated-liposomal doxorubicin (PLD) are highly effective in Kaposi sarcoma (KS).
  • Because of the efficacy of PLD in soft tissue sarcoma in general, and in KS in particular, coupled with potential similarities in KS and angiosarcoma, and the apparent activity of paclitaxel in angiosarcomas, the authors treated patients with angiosarcoma with either paclitaxel or PLD as initial chemotherapy.
  • METHODS: To better define the efficacy of these agents in angiosarcoma, the authors reviewed their experience with paclitaxel and PLD in patients with angiosarcoma treated between 1994 and 2004.
  • RESULTS: They identified seven patients with angiosarcoma treated with paclitaxel, and six treated with PLD.
  • Only one patient in the series had an angiosarcoma of the scalp.
  • Of the eight patients treated with paclitaxel, five had major responses (three had partial responses [PR] and two had complete disease remission [CR]) and three had progressive disease (PD).
  • Of the 6 patients who received PLD, 3 had a PR for 6, 19, and >20 months, respectively, 2 had stable disease for 7 and 11 months, respectively, and 1 had PD.
  • CONCLUSIONS: The current study demonstrated the activity of PLD (five of six patients experienced clinical benefit) and extended the data on paclitaxel in angiosarcoma, both of the face and scalp, as well as angiosarcoma originating at other sites.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Doxorubicin / therapeutic use. Hemangiosarcoma / drug therapy. Paclitaxel / therapeutic use

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  • (PMID = 15948172.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 30IQX730WE / Polyethylene Glycols; 80168379AG / Doxorubicin; P88XT4IS4D / Paclitaxel
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99. Yoo C, Kim JE, Yoon SK, Kim SC, Ahn JH, Kim TW, Suh C, Lee JL: Angiosarcoma of the retroperitoneum: report on a patient treated with sunitinib. Sarcoma; 2009;2009:360875

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma of the retroperitoneum: report on a patient treated with sunitinib.
  • A 52 year-old woman presented with an incidentally detected retroperitoneal angiosarcoma and multiple hepatic metastases.
  • After chemotherapy with weekly paclitaxel and doxorubicin, angiosarcoma had progressed rapidly.
  • With this case report, we suggest sunitinib may be effective against angiosarcomas.
  • When sunitinib is administered to patients with angiosarcomas, hematologic abnormalities should be monitored frequently as severe hematologic toxicity may be caused either by sunitinib per se or angiosarcoma.

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  • (PMID = 19478954.001).
  • [ISSN] 1357-714X
  • [Journal-full-title] Sarcoma
  • [ISO-abbreviation] Sarcoma
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC2685913
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100. Uchiyama Y, Murakami S, Kishino M, Furukawa S: A case report of primary gingival angiosarcoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2009 Dec;108(6):e17-21

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case report of primary gingival angiosarcoma.
  • Angiosarcoma is a rare malignant neoplasm and primary angiosarcoma is extremely rare.
  • This study reports clinico-pathological features and CT image finding of a case of primary angiosarcoma in the upper gingival and a review of previously reported cases of primary gingival angiosarcomas including the present case.
  • [MeSH-major] Gingival Neoplasms / pathology. Hemangiosarcoma / pathology. Maxillary Neoplasms / pathology

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  • (PMID = 19913715.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Interleukin-2; 0 / Recombinant Proteins
  • [Number-of-references] 12
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