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1. Park JW, Serafica-Karen C, Das K: Fine-needle aspiration of metastatic radiation-induced cutaneous epithelioid angiosarcoma of the breast to the liver: A diagnostic dilemma. Diagn Cytopathol; 2010 Oct;38(10):768-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fine-needle aspiration of metastatic radiation-induced cutaneous epithelioid angiosarcoma of the breast to the liver: A diagnostic dilemma.
  • Radiation therapy is a significant risk factor for the development of angiosarcoma.
  • With the increase in breast conservation treatment, the incidence of cutaneous radiation-induced angiosarcoma of the breast is rising.
  • If the angiosarcoma demonstrates epithelioid features, the tumor cells may present a diagnostic dilemma on fine-needle aspiration cytology.
  • We present a case of metastatic radiation-induced cutaneous epithelioid angiosarcoma of the breast to the liver and a review of the literature.
  • [MeSH-minor] Breast Neoplasms / metabolism. Breast Neoplasms / secondary. Carcinoma in Situ / radiotherapy. Carcinoma in Situ / surgery. Carcinoma, Ductal, Breast / radiotherapy. Carcinoma, Ductal, Breast / surgery. Cytodiagnosis. Diagnosis, Differential. Female. Hemangiosarcoma / metabolism. Hemangiosarcoma / secondary. Humans. Immunohistochemistry. Mastectomy, Segmental. Middle Aged. Radiotherapy, Adjuvant / adverse effects. Skin Neoplasms / metabolism. Skin Neoplasms / pathology

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  • [Copyright] © 2010 Wiley-Liss, Inc.
  • (PMID = 20187111.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] Angiosarcoma of the breast
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2. Anderson SE, Keohan ML, D'Adamo DR, Maki RG: A retrospective analysis of vinorelbine chemotherapy for patients with previously treated soft-tissue sarcomas. Sarcoma; 2006;2006:15947
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  • We present retrospective single institution experience with single-agent vinorelbine in subjects with metastatic soft tissue malignancies.
  • The overall response rate was 6% (3 patients: 1 angiosarcoma, 1 epithelioid sarcoma, and 1 embryonal rhabdomyosarcoma).

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  • (PMID = 17496991.001).
  • [ISSN] 1357-714X
  • [Journal-full-title] Sarcoma
  • [ISO-abbreviation] Sarcoma
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P01 CA047179
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC1698137
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3. Yoshida K, Ito F, Nakazawa H, Maeda Y, Tomoe H, Aiba M: A case of primary renal angiosarcoma. Rare Tumors; 2009;1(2):e28
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  • [Title] A case of primary renal angiosarcoma.
  • The renal specimen was re-evaluated using whole cross-section analysis and immunohistochemistry, and diagnosed as a primary renal angiosarcoma.
  • Recombinant interleukin-2 therapy was started immediately; however, the patient died of metastatic disease 13 months after the initial operation.
  • Although contrast imaging depicted the primary lesion as a non-specific hematoma with little focal pooling, and low-grade cytological atypia was shown pathologically, the angiosarcoma was extremely aggressive.

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  • (PMID = 21139907.001).
  • [ISSN] 2036-3613
  • [Journal-full-title] Rare tumors
  • [ISO-abbreviation] Rare Tumors
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2994470
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4. Rai S, Barthwal M, Bhattacharya P, Bhargava S, Pethe M: Metastatic angiosarcoma presenting as diffuse alveolar hemorrhage. Lung India; 2008 Jan;25(1):14-6
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  • [Title] Metastatic angiosarcoma presenting as diffuse alveolar hemorrhage.
  • Angiosarcoma is a rare malignant neoplasm of the vascular or lymphatic endothelium.
  • Diffuse alveolar hemorrhage is a rare presenting manifestation of angiosarcoma.
  • We describe a case of pulmonary metastasis of angiosarcoma who presented with diffuse alveolar hemorrhage as initial manifestation.

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  • (PMID = 20396655.001).
  • [ISSN] 0974-598X
  • [Journal-full-title] Lung India : official organ of Indian Chest Society
  • [ISO-abbreviation] Lung India
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2853041
  • [Keywords] NOTNLM ; Angiosarcoma / Diffuse alveolar hemorrhage / Metastatic
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5. Choi KS, Chun HJ, Yi HJ, Kim JT: Intracranial invasion from recurrent angiosarcoma of the scalp. J Korean Neurosurg Soc; 2008 Apr;43(4):201-4
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  • [Title] Intracranial invasion from recurrent angiosarcoma of the scalp.
  • Angiosarcoma of the brain, either primary or metastatic is extremely rare.
  • Moreover, angiosarcoma metastasizing to the brain is also highly unlike to occur comparing with metastases to the other organs.
  • A 67-year-old man with past surgical history of a scalp angiosarcoma underwent surgical resection of intracranial invasion.

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  • (PMID = 19096645.001).
  • [ISSN] 2005-3711
  • [Journal-full-title] Journal of Korean Neurosurgical Society
  • [ISO-abbreviation] J Korean Neurosurg Soc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2588263
  • [Keywords] NOTNLM ; Brain neoplasm / Metastasis / Scalp Angiosarcoma / Scalp flap
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6. Chen W, Shih CS, Wang YT, Tseng GC, Hsu WH: Angiosarcoma with pulmonary metastasis presenting with spontaneous bilateral pneumothorax in an elderly man. J Formos Med Assoc; 2006 Mar;105(3):238-41
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  • [Title] Angiosarcoma with pulmonary metastasis presenting with spontaneous bilateral pneumothorax in an elderly man.
  • Cutaneous angiosarcoma is a rare and invasive endothelial-derived sarcoma that occurs most frequently in the scalp and facial skin of elderly men.
  • We report a case of angiosarcoma of the scalp with cystic metastasis to the lung in a 63-year-old man, presenting as recurrent bilateral spontaneous pneumothorax.
  • Pneumothorax in the elderly should be differentiated from malignant metastatic lung tumors.

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  • (PMID = 16520841.001).
  • [ISSN] 0929-6646
  • [Journal-full-title] Journal of the Formosan Medical Association = Taiwan yi zhi
  • [ISO-abbreviation] J. Formos. Med. Assoc.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
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7. Thompson WM, Levy AD, Aguilera NS, Gorospe L, Abbott RM: Angiosarcoma of the spleen: imaging characteristics in 12 patients. Radiology; 2005 Apr;235(1):106-15
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  • [Title] Angiosarcoma of the spleen: imaging characteristics in 12 patients.
  • PURPOSE: To retrospectively review clinical, pathologic, and imaging features of angiosarcoma of the spleen in 12 patients.
  • Records of 12 cases of proved angiosarcoma of the spleen were accessed from the files of the Armed Forces Institute of Pathology.
  • Angiosarcoma of the spleen could be suggested in the majority of cases (83%) by using the imaging features of splenic mass with evidence of metastatic disease.
  • [MeSH-major] Hemangiosarcoma / diagnosis. Splenic Neoplasms / diagnosis

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  • [Copyright] (c) RSNA, 2005
  • (PMID = 15749977.001).
  • [ISSN] 0033-8419
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
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8. Candeias CM, Luís I, Ribeiro J, Costa L, de Almeida LS, Gomes MM, Barreto L, Brito-Avô L, Ducla-Soares JL: Extended remission of metastatic epithelioid angiosarcoma of the heart with liposomal doxorubicin. BMJ Case Rep; 2010;2010
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  • [Title] Extended remission of metastatic epithelioid angiosarcoma of the heart with liposomal doxorubicin.
  • Angiosarcoma is the most common primary malignant tumour of the heart.
  • Initial presentation with metastatic disease is unusual.
  • The skin biopsy was diagnosed as intravascular metastasis of epithelioid angiosarcoma.

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  • (PMID = 22347886.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3027499
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9. Quesenberry CD, Li C, Chen AH, Zweizig SL, Ball HG 3rd: Primary angiosarcoma of the ovary: a case report of Stage I disease. Gynecol Oncol; 2005 Oct;99(1):218-21
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  • [Title] Primary angiosarcoma of the ovary: a case report of Stage I disease.
  • BACKGROUND: There are 20 documented cases of primary ovarian angiosarcoma.
  • Most patients present with metastatic disease and respond poorly to chemotherapy.
  • CASE: We present a case of Stage Ic primary ovarian angiosarcoma treated with 3 cycles of adjuvant MAID chemotherapy.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Hemangiosarcoma / drug therapy. Ovarian Neoplasms / drug therapy

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  • (PMID = 16081151.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 7GR28W0FJI / Dacarbazine; 80168379AG / Doxorubicin; NR7O1405Q9 / Mesna; UM20QQM95Y / Ifosfamide; MAID protocol
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10. Saitoh J, Sakurai H, Suzuki Y, Katoh H, Takahashi T, Nakano T: Metastatic angiosarcoma of the lung with alveolar hemorrhage. Jpn J Radiol; 2009 Nov;27(9):381-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic angiosarcoma of the lung with alveolar hemorrhage.
  • A case of metastatic angiosarcoma of the lung with alveolar hemorrhage was experienced.
  • By immunohistochemical staining, CD31, CD34 and Factor VIII were found to be positive, and the tumor was diagnosed as epithelioid angiosarcoma.
  • [MeSH-major] Hemangiosarcoma / complications. Hemangiosarcoma / secondary. Hemorrhage / etiology. Lung Neoplasms / complications. Lung Neoplasms / secondary. Uterine Cervical Neoplasms / pathology


11. Wang J, Yin J, Zou C, Xie X, Huang G, Li H, Shen J, Han S: [Surgical treatment of proximal femoral malignant tumors]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi; 2010 Jul;24(7):881-4
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  • In 41 patients with primary malignant tumors having a disease course of 0.5-14.0 months, there were 16 cases of osteosarcoma, 7 cases of fibrosarcoma, 6 cases of chondrosarcoma, 6 cases of malignant fibrous histiocytoma, 4 cases of mesenchymal sarcoma,1 case of Ewing sarcoma, and 1 case of angiosarcoma, including 3 cases of type IB, 2 cases of type IIA, 35 cases of type IIB, and 1 case of type III according to Enneking stage.
  • In 21 patients with metastatic tumors, 16 had a malignant tumor history; the disease course was 0.1-28.0 months (3.4 months on average).

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  • (PMID = 20695391.001).
  • [ISSN] 1002-1892
  • [Journal-full-title] Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
  • [ISO-abbreviation] Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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12. Maki RG, D'Adamo DR, Keohan ML, Saulle M, Schuetze SM, Undevia SD, Livingston MB, Cooney MM, Hensley ML, Mita MM, Takimoto CH, Kraft AS, Elias AD, Brockstein B, Blachère NE, Edgar MA, Schwartz LH, Qin LX, Antonescu CR, Schwartz GK: Phase II study of sorafenib in patients with metastatic or recurrent sarcomas. J Clin Oncol; 2009 Jul 01;27(19):3133-40
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  • [Title] Phase II study of sorafenib in patients with metastatic or recurrent sarcomas.
  • PURPOSE Since activity of sorafenib was observed in sarcoma patients in a phase I study, we performed a multicenter phase II study of daily oral sorafenib in patients with recurrent or metastatic sarcoma.
  • In each arm, 12 patients who received 0 to 1 prior lines of therapy were treated (0 to 3 for angiosarcoma and malignant peripheral-nerve sheath tumor).
  • Five of 37 patients with angiosarcoma had a partial response (response rate, 14%).
  • There was no correlation between phosphorylated extracellular signal regulated kinase expression and response in six patients with angiosarcoma with paired pre- and post-therapy biopsies.
  • CONCLUSION As a single agent, sorafenib has activity against angiosarcoma and minimal activity against other sarcomas.

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  • (PMID = 19451436.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / N01CM62202; United States / NCI NIH HHS / CA / P01 CA047179
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzenesulfonates; 0 / Phenylurea Compounds; 0 / Pyridines; 25X51I8RD4 / Niacinamide; 9ZOQ3TZI87 / sorafenib
  • [Other-IDs] NLM/ PMC2716936
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13. Manouras A, Giannopoulos P, Toufektzian L, Markogiannakis H, Lagoudianakis EE, Papadima A, Papanikolaou D, Filis K, Kekis P: Splenic rupture as the presenting manifestation of primary splenic angiosarcoma in a teenage woman: a case report. J Med Case Rep; 2008;2:133
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Splenic rupture as the presenting manifestation of primary splenic angiosarcoma in a teenage woman: a case report.
  • INTRODUCTION: Primary splenic angiosarcoma is a rare neoplasm of vascular origin carrying a very poor prognosis, partly due to its high metastatic potential.
  • We report the case of a 17-year-old woman who presented with rupture of a primary splenic angiosarcoma.
  • Histopathology showed a primary splenic angiosarcoma.
  • CONCLUSION: Primary splenic angiosarcoma is rare.

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  • (PMID = 18445294.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2387157
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14. Castaldo ET, Pinson CW: Liver transplantation for non-hepatocellular carcinoma malignancy. HPB (Oxford); 2007;9(2):98-103
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • LT for other malignancies like cholangiocarcinoma (CCA), hepatoblastoma (HB), hepatic epithelioid hemangioepithelioma (HEHE), angiosarcoma (AS), and neuroendocrine tumors (NET) is being defined.
  • For NET, resection of the primary tumor and all gross metastatic disease is reported to provide 5-year survival of 70-85%.

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  • (PMID = 18333123.001).
  • [ISSN] 1365-182X
  • [Journal-full-title] HPB : the official journal of the International Hepato Pancreato Biliary Association
  • [ISO-abbreviation] HPB (Oxford)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2020792
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15. Deyrup AT, Tighiouart M, Montag AG, Weiss SW: Epithelioid hemangioendothelioma of soft tissue: a proposal for risk stratification based on 49 cases. Am J Surg Pathol; 2008 Jun;32(6):924-7
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  • Epithelioid hemangioendothelioma (EHE) of soft tissue is a distinctive vascular tumor that has been variously considered a tumor of borderline malignancy and low-grade angiosarcoma.
  • Eleven patients (22%) had metastatic disease affecting lung (6), lymph node (4), liver (2), and bone, retroperitoneum, and soft tissue (1 each).

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  • (PMID = 18551749.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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16. Avramut M, Parwani AV: Metastatic angiosarcoma in an ileal conduit: an unusual presentation. Int J Surg Pathol; 2009 Feb;17(1):60-4
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  • [Title] Metastatic angiosarcoma in an ileal conduit: an unusual presentation.
  • The authors in this study describe the case of a patient with a history of multiple malignancies who underwent total cystectomy with ileal loop urinary diversion and presented with a lower extremity angiosarcoma on the background of lymphedema a decade later.
  • Shortly thereafter, she was diagnosed with metastatic ileal conduit angiosarcoma.
  • The authors state that to their knowledge, this is the first case of ileal conduit angiosarcoma reported in the English literature.
  • [MeSH-major] Hemangiosarcoma / diagnosis. Hemangiosarcoma / secondary. Ileal Neoplasms / diagnosis. Ileal Neoplasms / secondary. Urinary Diversion

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  • (PMID = 18499689.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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17. Hertl M, Cosimi AB: Liver transplantation for malignancy. Oncologist; 2005 Apr;10(4):269-81
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  • Epitheloid hemangioendothelioma is also an appropriate indication for liver transplantation, unlike angiosarcoma.
  • Metastatic liver disease is not an indication for liver transplantation, with the exception of cases in which the primary is a neuroendocrine tumor, for which liver transplantation can result in long-term survival and even cure in a number of patients.


18. Fulciniti F, Di Mattia D, Bove P, Mastro AA, De Chiara A, Botti G, Petrillo A, Apice G: Fine needle aspiration of metastatic epithelioid angiosarcoma: a report of 2 cases. Acta Cytol; 2008 Sep-Oct;52(5):612-8
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  • [Title] Fine needle aspiration of metastatic epithelioid angiosarcoma: a report of 2 cases.
  • In both cases a cytopathologic diagnosis of metastatic EA was made.
  • Knowledge of the clinical history is of great help in diagnosing metastatic lesions.
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Hemangiosarcoma / diagnosis

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  • (PMID = 18833827.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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19. Grewal JS, Daniel AR, Carson EJ, Catanzaro AT, Shehab TM, Tworek JA: Rapidly progressive metastatic multicentric epithelioid angiosarcoma of the small bowel: a case report and a review of literature. Int J Colorectal Dis; 2008 Aug;23(8):745-56
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  • [Title] Rapidly progressive metastatic multicentric epithelioid angiosarcoma of the small bowel: a case report and a review of literature.
  • BACKGROUND: Angiosarcoma is a rare high-grade neoplasm that frequently involves the skin and subcutaneous tissue.
  • Rarely, angiosarcoma can occur in the gastrointestinal tract where it frequently exhibits multicentric epithelioid morphology.
  • DESIGN: We report a case of multicentric epithelioid angiosarcoma (EAS) of the small intestine in a 73-year-old male patient who presented with weakness and melena, and was found to have bleeding lesions in the small intestine on upper gastrointestinal endoscopy.
  • In addition to this case, we extensively reviewed the clinical and pathological features of previously reported cases of angiosarcoma of the small intestine in the English literature since 1970.
  • Despite surgical resection of the lesions, the patient continued to worsen and developed rapidly progressive metastatic disease.
  • CONCLUSIONS: Angiosarcoma, especially of the deep tissues and the gastrointestinal tract, is very aggressive and rapidly metastatic.
  • [MeSH-major] Hemangiosarcoma / pathology. Hemangiosarcoma / secondary. Intestinal Neoplasms / pathology. Intestine, Small / pathology

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  • (PMID = 18080128.001).
  • [ISSN] 0179-1958
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 59
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20. Souza FF, Katkar A, den Abbeele AD, Dipiro PJ: Breast angiosarcoma metastatic to the ovary. Case Rep Med; 2009;2009:381015
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  • [Title] Breast angiosarcoma metastatic to the ovary.
  • Approximately 5%-10% of ovarian malignancies are diagnosed as metastatic tumors.
  • Primary angiosarcoma can arise anywhere in the body and when it arises in the breast, it usually affects women in their 3rd and 4th decades and accounts for one in 1700-2300 cases of primary breast cancer.
  • We present a case of a solitary ovarian metastasis from angiosarcoma of the breast.

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  • (PMID = 19718246.001).
  • [ISSN] 1687-9627
  • [Journal-full-title] Case reports in medicine
  • [ISO-abbreviation] Case Rep Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2729273
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21. Mitsuhashi T, Shimizu Y, Ban S, Ogawa F, Hirose T, Tanaka J, Shimizu M: Multicentric contiguous variant of epithelioid angiosarcoma of the bone. A rare variant showing angiotropic spread. Ann Diagn Pathol; 2005 Feb;9(1):33-7
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  • [Title] Multicentric contiguous variant of epithelioid angiosarcoma of the bone. A rare variant showing angiotropic spread.
  • Epithelioid angiosarcoma of the bone is a rare tumor and is a diagnostic challenge.
  • Multicentric epithelioid angiosarcoma of the bone is a pitfall in pathological diagnoses, especially if a strong radiological impression of metastatic carcinoma is provided.
  • [MeSH-major] Bone Neoplasms / pathology. Epithelioid Cells / pathology. Hemangiosarcoma / secondary. Neoplasms, Multiple Primary / pathology

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  • (PMID = 15692948.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Biomarkers, Tumor; 0 / Vimentin; 0 / von Willebrand Factor; 68238-35-7 / Keratins
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22. Wierzbicka-Hainaut E, Guillet G: [Stewart-Treves syndrome (angiosarcoma on lyphoedema): A rare complication of lymphoedema]. Presse Med; 2010 Dec;39(12):1305-8
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  • [Title] [Stewart-Treves syndrome (angiosarcoma on lyphoedema): A rare complication of lymphoedema].
  • [Transliterated title] Syndrome de Stewart-Treves (angiosarcome sur lymphœdème) : complication rare du lymphœdème.
  • Locally advanced tumors or metastatic forms can be treated with mono or polychemotherapy, systemic or local.
  • [MeSH-minor] Breast Neoplasms / mortality. Breast Neoplasms / surgery. Chronic Disease. Combined Modality Therapy. Female. Hemangiosarcoma / diagnosis. Hemangiosarcoma / etiology. Hemangiosarcoma / mortality. Hemangiosarcoma / therapy. Humans. Lymphangiosarcoma / diagnosis. Lymphangiosarcoma / etiology. Lymphangiosarcoma / mortality. Lymphangiosarcoma / therapy. Mastectomy, Radical. Postoperative Complications / diagnosis. Postoperative Complications / etiology. Postoperative Complications / mortality. Prognosis. Survival Rate

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  • [Copyright] Copyright © 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20970956.001).
  • [ISSN] 2213-0276
  • [Journal-full-title] Presse medicale (Paris, France : 1983)
  • [ISO-abbreviation] Presse Med
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Chemical-registry-number] Stewart Treves syndrome
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23. Fontanesi J, Mott MP, Kraut MJ, Lucas DR, Miller PR: A unique radiation scheme for the treatment of high-grade non-metastatic soft tissue sarcoma: the detroit medical center experience. Sarcoma; 2005;9(3-4):141-5
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  • [Title] A unique radiation scheme for the treatment of high-grade non-metastatic soft tissue sarcoma: the detroit medical center experience.
  • PURPOSE: This is the initial report on the utilization of combined photon irradiation followed by a neutron boost irradiation for the initial management of patients with high-grade non-metastatic soft tissue sarcoma (STS).
  • METHODS AND MATERIALS: Between 1/1/1995 and 10/31/02, twenty-three patients with high-grade non-metastatic soft tissue sarcoma were referred to the Department of Radiation Oncology at the Detroit Medical Center.
  • The most common histology was malignant fibrous histiocytoma (n=6), followed by liposarcoma (n=5), synovial sarcoma (n=4), and angiosarcoma (n=2).

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  • (PMID = 18521422.001).
  • [ISSN] 1357-714X
  • [Journal-full-title] Sarcoma
  • [ISO-abbreviation] Sarcoma
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC2395635
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24. Sakurai H, Hada M, Miyashita Y, Tsukamoto K, Oyama T, Ashizawa I: Simultaneous bilateral spontaneous pneumothorax secondary to metastatic angiosarcoma of the scalp: report of a case. Surg Today; 2006;36(10):919-22
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  • [Title] Simultaneous bilateral spontaneous pneumothorax secondary to metastatic angiosarcoma of the scalp: report of a case.
  • Angiosarcoma is a highly malignant neoplasm, which most often develops on the scalp or face of elderly people.
  • Common distant metastatic sites include the lung, liver, lymph nodes, and skin.
  • We report a case of angiosarcoma manifesting as simultaneous bilateral spontaneous pneumothorax secondary to pulmonary metastases in an 86-year-old man.
  • The pneumothorax preceded the diagnosis of angiosarcoma.
  • Chest computed tomography showed multiple thin-walled cavitary metastatic pulmonary lesions, which increased in size as new lesions appeared over the clinical course of several months.
  • [MeSH-major] Head and Neck Neoplasms / complications. Hemangiosarcoma / complications. Lung Neoplasms / complications. Pneumothorax / etiology. Scalp. Skin Neoplasms / complications


25. Kim SW, Wylie J: Spontaneous regression of pulmonary metastases from breast angiosarcoma. Sarcoma; 2008;2008:940656
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  • [Title] Spontaneous regression of pulmonary metastases from breast angiosarcoma.
  • We present a rare case of pulmonary metastases in a 72-year-old woman with metastatic breast angiosarcoma.
  • She was diagnosed with a breast angiosarcoma in 2005 and underwent a total mastectomy and postoperative radiotherapy.
  • Seven months after the diagnosis of metastatic disease, the nodules in her scalp remain controlled.

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  • (PMID = 19081840.001).
  • [ISSN] 1357-714X
  • [Journal-full-title] Sarcoma
  • [ISO-abbreviation] Sarcoma
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC2593410
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26. Zhang G, Lu Q, Yin H, Wen H, Su Y, Li D, Xiao R: A case of retiform-hemangioendothelioma with unusual presentation and aggressive clinical features. Int J Clin Exp Pathol; 2010;3(5):528-33
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  • Retiform hemangioendothelioma (RH) is an extremely rare low-grade angiosarcoma mainly involving the skin and subcutaneous tissue.
  • RH is characterized by frequent local recurrences but a very low metastatic rate.
  • [MeSH-major] Hemangioendothelioma / pathology. Hemangiosarcoma / pathology. Scalp / pathology. Skin Neoplasms / pathology

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  • [Cites] J Am Acad Dermatol. 2000 Feb;42(2 Pt 1):290-2 [10642690.001]
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  • (PMID = 20606734.001).
  • [ISSN] 1936-2625
  • [Journal-full-title] International journal of clinical and experimental pathology
  • [ISO-abbreviation] Int J Clin Exp Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2897105
  • [Keywords] NOTNLM ; Retiform hemangioendothelioma / headache / recurrence
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27. Chen TJ, Chiou CC, Chen CH, Kuo TT, Hong HS: Metastasis of mediastinal epithelioid angiosarcoma to the finger. Am J Clin Dermatol; 2008;9(3):181-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastasis of mediastinal epithelioid angiosarcoma to the finger.
  • Epithelioid angiosarcoma (EA) is a rare malignant, vascular tumor that is usually observed in middle-aged and elderly males.
  • The skin biopsy specimen revealed metastatic EA.
  • Whenever a patient has metastatic disease, acrometastases should be considered in the differential diagnosis of inflammatory lesions of the digits and a skin biopsy should be performed.

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  • (PMID = 18429648.001).
  • [ISSN] 1175-0561
  • [Journal-full-title] American journal of clinical dermatology
  • [ISO-abbreviation] Am J Clin Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] New Zealand
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28. Simpson L, Kumar SK, Okuno SH, Schaff HV, Porrata LF, Buckner JC, Moynihan TJ: Malignant primary cardiac tumors: review of a single institution experience. Cancer; 2008 Jun;112(11):2440-6
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  • The most common histologic type was angiosarcoma (41%).
  • Patients with angiosarcoma had a lower survival compared with patients with other histologies (5 months vs 17 months; P = .01).
  • The median survival of patients with metastatic disease was 5 months versus 15 months in patients without metastatic disease (P = .03 by the log-rank test).

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  • [Copyright] (c) 2008 American Cancer Society.
  • (PMID = 18428209.001).
  • [ISSN] 1097-0142
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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29. Rossi G, Sartori G, Valli R, Bertolini F, Bigiani N, Schirosi L, Cavazza A, Luppi G: The value of c-kit mutational analysis in a cytokeratin positive gastrointestinal stromal tumour. J Clin Pathol; 2005 Sep;58(9):991-3
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  • This report describes a metastatic GIST that stained strongly for cytokeratins, CD117, and CD34 in a patient who was previously diagnosed with gastric epithelioid angiosarcoma.
  • [MeSH-minor] Adult. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Female. Hemangiosarcoma / diagnosis. Humans. Pelvic Neoplasms / diagnosis. Pelvic Neoplasms / secondary

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  • (PMID = 16126886.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 68238-35-7 / Keratins; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
  • [Other-IDs] NLM/ PMC1770815
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30. Cioffi-Pretti JL, Kalof AN, Ebert G, McCahill LE: Hepatic angiosarcoma five years following spontaneous intraperitoneal bleed of a hepatic mass. Rare Tumors; 2009;1(2):e33
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hepatic angiosarcoma five years following spontaneous intraperitoneal bleed of a hepatic mass.
  • Primary hepatic angiosarcoma is a rare and rapidly fatal disease.
  • A metastatic workup was negative and the decision was made to observe the patient clinically with radiographic follow-up, given his suspected portal hypertension based on thrombocytopenia and splenomegaly.Sequential imaging demonstrated a decrease in the size of the mass from 12.0 cm in 2003 to 3.0 cm in 2007.
  • An extremely vascular lesion with surrounding dense fibrosis was identified and pathologic examination demonstrated a high-grade angiosarcoma.We are unaware of any previous reports suggesting such a prolonged natural history of hepatic angiosarcoma.
  • This case may represent the possibility of malignant transformation of a lower grade vascular neoplasm such as hepatic epithelioid hemangioendothelioma to an angiosarcoma.

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  • (PMID = 21139912.001).
  • [ISSN] 2036-3613
  • [Journal-full-title] Rare tumors
  • [ISO-abbreviation] Rare Tumors
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2994458
  • [Keywords] NOTNLM ; hepatic angiosarcoma / hepatic mass / spontaneous intraperitoneal bleed.
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31. Brush M, Zhang J, Schuetze S, Sires B: Angiosarcoma metastatic to the orbit. Ophthal Plast Reconstr Surg; 2006 Jan-Feb;22(1):62-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma metastatic to the orbit.
  • A 61-year-old woman developed metastatic angiosarcoma in her left orbit.
  • Angiosarcoma was confirmed with histologic analysis.
  • Chemotherapy may be a useful palliative adjunct in the control of metastatic orbital angiosarcoma.
  • [MeSH-major] Breast Neoplasms / pathology. Hemangiosarcoma / secondary. Orbital Neoplasms / secondary

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  • (PMID = 16418673.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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32. Smigla GR, Lawson DS, Kaemmer DD, Shearer IR: Venous line filtration: a novel technique for cases involving inferior vena caval and right atrial tumor and associated thrombus: a two-case series. Perfusion; 2006 Nov;21(6):391-4
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  • The first case was a 44-year-old female (81 kg, 137 cm, body surface area (BSA) 1.66 m2) who presented with a metastatic pheochromocytoma with associated thrombus arising from the left adrenal gland and extending into the inferior vena cava (IVC) and right atrium.
  • The second case was a 37-year-old male (95 kg, 178 cm, BSA 2.17 m2), who presented with a very large angiosarcoma tumor involving almost the entire right atrium.
  • [MeSH-major] Heart Neoplasms / surgery. Hemangiosarcoma / surgery. Intraoperative Complications / prevention & control. Neoplastic Cells, Circulating. Vena Cava Filters

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  • (PMID = 17312864.001).
  • [ISSN] 0267-6591
  • [Journal-full-title] Perfusion
  • [ISO-abbreviation] Perfusion
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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33. Miettinen M: From morphological to molecular diagnosis of soft tissue tumors. Adv Exp Med Biol; 2006;587:99-113
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  • Activating mutations in two related receptor tyrosine kinases (RTKs), KIT, and platelet-derived growth factor receptor alpha (PDGFRA) is central to the pathogenesis of gastrointestinal stromal tumors (GISTs), and countering the mutational activation by specific tyrosine kinase inhibitors, such as Imatinib mesylate, is now standard treatment for metastatic GISTs.
  • Specific viral sequences of human herpesvirus 8 (HHV8) are diagnostic markers for Kaposi sarcoma (KS), and are absent in angiosarcoma.

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  • (PMID = 17163160.001).
  • [ISSN] 0065-2598
  • [Journal-full-title] Advances in experimental medicine and biology
  • [ISO-abbreviation] Adv. Exp. Med. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 70
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34. Moriya Y, Sugawara T, Arai M, Tsuda Y, Uchida K, Noguchi T, Arai T, Takahashi H: Bilateral massive bloody pleurisy complicated by angiosarcoma. Intern Med; 2007;46(3):125-8
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  • [Title] Bilateral massive bloody pleurisy complicated by angiosarcoma.
  • We report a case of angiosarcoma complicated by bilateral massive bloody pleurisy (hematocrit of 7.2%) in an 83-year-old woman.
  • Histological examination confirmed an anastomosing vascular channel pattern of the tumor cells with characteristic immunohistochemical findings for angiosarcoma, such as positive staining for vimentin, CD31, CD34, D2-40, and factor VIII-related antigen.
  • We also reviewed cases of hemothorax associated with angiosarcoma, which suggested that primary or metastatic pleural angiosarcoma should be considered a cause of spontaneous hemothorax, especially in patients with bilateral and/or intractable hemothorax.
  • [MeSH-major] Hemangiosarcoma / pathology. Hemothorax / etiology. Intestinal Neoplasms / pathology. Pleurisy / etiology

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  • (PMID = 17268128.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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35. Pace V, Wieczorek G, Pace M, Weber K, Perentes E: Spontaneous metastatic angiosarcoma of the tongue in a Wistar rat: morphological and immunohistochemical characterization. Toxicol Pathol; 2010 Apr;38(3):472-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spontaneous metastatic angiosarcoma of the tongue in a Wistar rat: morphological and immunohistochemical characterization.
  • A primary angiosarcoma was found in the tongue of a six-week-old female Wistar rat, sacrificed for humane reasons during the course of a four-week toxicology study.
  • The diagnosis of tongue angiosarcoma metastasizing to the lungs was made on the basis of microscopic and immunohistochemical findings.
  • [MeSH-major] Hemangiosarcoma / secondary. Hemangiosarcoma / veterinary. Lung Neoplasms / secondary. Lung Neoplasms / veterinary. Tongue Neoplasms / pathology. Tongue Neoplasms / veterinary

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  • (PMID = 20215585.001).
  • [ISSN] 1533-1601
  • [Journal-full-title] Toxicologic pathology
  • [ISO-abbreviation] Toxicol Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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36. Gagnon PJ, Galderisi C, Page BR, Holland JM: Angiosarcoma developing after curative induction chemotherapy and radiotherapy for locally advanced squamous cell carcinoma of the larynx. Head Neck; 2009 Jun;31(6):829-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma developing after curative induction chemotherapy and radiotherapy for locally advanced squamous cell carcinoma of the larynx.
  • BACKGROUND: Angiosarcoma arising after radiation is described in breast cancer but occurs elsewhere.
  • Here, we present an angiosarcoma of the neck occurring after curative chemoradiation.
  • METHODS: This is a case of angiosarcoma developing 5 years after curative therapy for T3N0 squamous cell carcinoma of the supraglottic larynx.
  • Examination showed a 7-cm mass and biopsy revealed angiosarcoma.
  • CT scans assessed the local extent of the tumor and ruled out metastatic disease prior to initiating therapy.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / adverse effects. Carcinoma, Squamous Cell / therapy. Hemangiosarcoma / etiology. Laryngeal Neoplasms / therapy. Radiotherapy, High-Energy / adverse effects. Skin Neoplasms / etiology

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  • [Copyright] (c) 2008 Wiley Periodicals, Inc.
  • (PMID = 18853452.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] P88XT4IS4D / Paclitaxel
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37. Kluger N, Girard C, Boissier E, Sibille L, Mariano-Goulart D, Guillot B: Metastatic cutaneous angiosarcoma complicated with severe thrombocytopenia. Eur J Dermatol; 2010 Sep-Oct;20(5):662-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic cutaneous angiosarcoma complicated with severe thrombocytopenia.
  • [MeSH-major] Head and Neck Neoplasms / complications. Hemangiosarcoma / complications. Hemangiosarcoma / secondary. Scalp. Skin Neoplasms / complications. Skin Neoplasms / pathology. Thrombocytopenia / complications

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  • (PMID = 20634170.001).
  • [ISSN] 1167-1122
  • [Journal-full-title] European journal of dermatology : EJD
  • [ISO-abbreviation] Eur J Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] France
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38. Sadhu S, Pattari S, Shaikh F, Verma R, Roy MK: Colonic metastasis from subcutaneous angiosarcoma: A diagnostic dilemma. Indian J Surg; 2010 Jul;72(Suppl 1):328-30
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  • [Title] Colonic metastasis from subcutaneous angiosarcoma: A diagnostic dilemma.
  • Primary angiosarcoma is an extremely rare and aggressive soft-tissue malignancy of endothelial cell origin that occurs most frequently in the skin and subcutaneous tissues of the extremities.
  • Presence of this disease in the intestine as a primary or metastatic deposit is an extremely uncommon incident, and might causes diagnostic confusion with primary colonic neoplasm.
  • We encountered epithelioid angiosarcoma of the sigmoid colon in a 59-year-old male patient who presented with occasional bleeding per rectum and had also had an angiosarcoma arising from the subcutaneous tissue of the right thigh.

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  • (PMID = 23133287.001).
  • [ISSN] 0972-2068
  • [Journal-full-title] The Indian journal of surgery
  • [ISO-abbreviation] Indian J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3451850
  • [Keywords] NOTNLM ; Angiosarcoma / Colonic metastasis
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39. Mathew P, Vakar-Lopez F, Troncoso P: Protracted remission of metastatic epithelioid angiosarcoma with weekly infusion of doxorubicin, paclitaxel, and cisplatin. Lancet Oncol; 2006 Jan;7(1):92-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Protracted remission of metastatic epithelioid angiosarcoma with weekly infusion of doxorubicin, paclitaxel, and cisplatin.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Hemangiosarcoma / drug therapy. Hemangiosarcoma / pathology. Testicular Neoplasms / drug therapy. Testicular Neoplasms / pathology

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  • (PMID = 16389189.001).
  • [ISSN] 1470-2045
  • [Journal-full-title] The Lancet. Oncology
  • [ISO-abbreviation] Lancet Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 80168379AG / Doxorubicin; P88XT4IS4D / Paclitaxel; Q20Q21Q62J / Cisplatin
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40. Eng SP, Goh CH, Khoo JB, Yang TL, Lim LH: Metastatic angiosarcoma to the thyroid. Rev Laryngol Otol Rhinol (Bord); 2005;126(2):111-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic angiosarcoma to the thyroid.
  • BACKGROUND: Angiosarcoma (AS) in non-alpine areas is exceptionally rare, and so is metastatic AS to the thyroid.
  • RESULTS: A Chinese gentleman with AS metastatic to the thyroid presented a year after radiotherapy to his scalp AS.
  • CONCLUSION: AS metastatic to the thyroid is possible.
  • [MeSH-major] Hemangiosarcoma / secondary. Thyroid Neoplasms / secondary

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  • (PMID = 16180351.001).
  • [ISSN] 0035-1334
  • [Journal-full-title] Revue de laryngologie - otologie - rhinologie
  • [ISO-abbreviation] Rev Laryngol Otol Rhinol (Bord)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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41. Agarwal PP, Dennie CJ, Matzinger FR, Peterson RA, Seely JM: Pulmonary artery pseudoaneurysm secondary to metastatic angiosarcoma. Thorax; 2006 Apr;61(4):366
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pulmonary artery pseudoaneurysm secondary to metastatic angiosarcoma.
  • [MeSH-major] Aneurysm, False / radiography. Head and Neck Neoplasms. Hemangiosarcoma / secondary. Lung Neoplasms / secondary. Pulmonary Artery / radiography. Soft Tissue Neoplasms

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  • [Cites] AJR Am J Roentgenol. 2003 Jun;180(6):1671-4 [12760941.001]
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  • (PMID = 16565273.001).
  • [ISSN] 0040-6376
  • [Journal-full-title] Thorax
  • [ISO-abbreviation] Thorax
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2104616
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42. Hsu JT, Chen HM, Lin CY, Yeh CN, Hwang TL, Jan YY, Chen MF: Primary angiosarcoma of the spleen. J Surg Oncol; 2005 Dec 15;92(4):312-6
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  • [Title] Primary angiosarcoma of the spleen.
  • BACKGROUND AND OBJECTIVES: Primary splenic angiosarcoma is a very rare and aggressive neoplasm with a high metastatic rate and dismal prognosis.
  • METHODS: The records of all cases of primary splenic angiosarcoma treated at Chang Gung Memorial Hospital from April 1991 to July 2004 were retrospectively reviewed.
  • CONCLUSIONS: The clinical presentations of splenic angiosarcoma were similar to those of previous reports apart from the higher rate of splenomegaly observed in this study.
  • [MeSH-major] Hemangiosarcoma. Splenic Neoplasms

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  • [Copyright] 2005 Wiley-Liss, Inc.
  • (PMID = 16299797.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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43. Carassai P, Caput M: Report of a case of epithelioid hemangioendothelioma of the anterior mediastinum metastatic to pleura. Pathologica; 2010 Jun;102(3):112-4
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  • [Title] Report of a case of epithelioid hemangioendothelioma of the anterior mediastinum metastatic to pleura.
  • We present a case of epithelioid hemangioendothelioma metastatic to pleura, in a 69-year-old woman with chest pain.
  • Epithelioid hemangioendothelioma should be distinguished mainly from primary or metastatic carcinomas and angiosarcoma.
  • Its clinical course is unpredictable, although survival rates are better than for angiosarcoma.

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  • (PMID = 21171516.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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44. Agaimy A, Wünsch PH: Distribution of neural cell adhesion molecule (NCAM/CD56) in gastrointestinal stromal tumours and their intra-abdominal mesenchymal mimics. J Clin Pathol; 2008 Apr;61(4):499-503
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  • METHODS: 275 histologically and immunohistochemically well characterised primary and metastatic intra-abdominal mesenchymal lesions were analysed by conventional immunohistochemistry, with emphasis on GIST and GI smooth muscle neoplasms.
  • Mesenteric fibromatoses, angiosarcoma/Kaposi sarcoma, reactive tumefactive fibrogenic lesions and 12/13 primary anorectal and oesophageal melanomas were negative.

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  • (PMID = 17923471.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD56; 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins
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45. Armah HB, Rao UN, Parwani AV: Primary angiosarcoma of the testis: report of a rare entity and review of the literature. Diagn Pathol; 2007;2:23
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  • [Title] Primary angiosarcoma of the testis: report of a rare entity and review of the literature.
  • After excluding 2 cases because they did not involve the testis, we identified 4 previously reported cases of true primary testicular angiosarcoma.
  • One patient had multiple metastatic recurrences but eventual outcome was not available, and 1 patient died a month after diagnosis from stroke but no autopsy was performed.

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  • (PMID = 17601346.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1919353
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46. Scheinfeld N: Review of scalp alopecia due to a clinically unapparent or minimally apparent neoplasm (SACUMAN). Acta Derm Venereol; 2006;86(5):387-92
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  • Neoplastic cells, both malignant and benign, local occurring and metastatic, can cause alopecia of the scalp.
  • The most common neoplasm in which an uncomplicated, minimally or unapparent scalp alopecia occurs and no infiltrate of cancer is suspected is metastatic breast carcinoma.
  • Other causes include squamous and basal cell carcinomas, angiosarcoma, gastric carcinoma, placental site tromphoblastic tumor, and mycosis fungoides.
  • Dermatologists must be aware that in rare cases a bland scalp alopecia can represent a new or recurring, local or metastatic neoplasm.
  • [MeSH-minor] Breast Neoplasms / pathology. Carcinoma, Basal Cell / pathology. Cicatrix / pathology. Hemangiosarcoma / pathology. Humans. Keloid / complications. Keloid / pathology. Lymphoma / pathology. Scalp / pathology

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  • (PMID = 16983449.001).
  • [ISSN] 0001-5555
  • [Journal-full-title] Acta dermato-venereologica
  • [ISO-abbreviation] Acta Derm. Venereol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Norway
  • [Number-of-references] 56
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47. Asgari MM, Cockerell CJ, Weitzul S: The head-tilt maneuver: a clinical aid in recognizing head and neck angiosarcomas. Arch Dermatol; 2007 Jan;143(1):75-7
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  • BACKGROUND: Cutaneous angiosarcoma is a rare, life-threatening tumor that is often initially misdiagnosed.
  • This delay in diagnosis can affect tumor growth, metastatic potential, and prognosis.
  • [MeSH-major] Head Movements. Head and Neck Neoplasms / diagnosis. Hemangiosarcoma / diagnosis. Skin / pathology

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  • (PMID = 17224545.001).
  • [ISSN] 0003-987X
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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48. Benoit L, Arnould L, Cheynel N, Goui S, Collin F, Fraisse J, Cuisenier J: The role of surgery and treatment trends in uterine sarcoma. Eur J Surg Oncol; 2005 May;31(4):434-42
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  • The control of pelvic, local and/or metastatic disease were also studied.
  • RESULTS: The histological types consisted in 34 leiomyosarcomas, 25 mixte mullerian tumours, 12 endometrial stromal sarcoma and one angiosarcoma.
  • Local and regional disease control, as adjuvant therapies do not seem to decrease the risk of metastatic spread or increase survival.

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  • (PMID = 15837053.001).
  • [ISSN] 0748-7983
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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49. Abbott R, Palmieri C: Angiosarcoma of the breast following surgery and radiotherapy for breast cancer. Nat Clin Pract Oncol; 2008 Dec;5(12):727-36
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  • [Title] Angiosarcoma of the breast following surgery and radiotherapy for breast cancer.
  • Breast angiosarcoma following surgery and radiotherapy for breast cancer is a rare but important clinical entity.
  • Breast angiosarcoma remains challenging clinically, radiologically and histologically, and thus a high index of suspicion is required in susceptible patients.
  • There have been recent reports of patients with metastatic disease responding to taxane chemotherapy, and there might be a future role for targeted agents given the expression of c-KIT in a subset of angiosarcomas.
  • [MeSH-major] Breast Neoplasms / epidemiology. Hemangiosarcoma / epidemiology. Neoplasm Recurrence, Local / epidemiology. Neoplasms, Radiation-Induced

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  • (PMID = 18936792.001).
  • [ISSN] 1743-4262
  • [Journal-full-title] Nature clinical practice. Oncology
  • [ISO-abbreviation] Nat Clin Pract Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 90
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50. Magri K, Demoulin G, Millon G, Duvert B: [Metastasis to the breast from non mammary metastasis. Clinical, radiological characteristics and diagnostic process. A report of two cases and a review of literature]. J Gynecol Obstet Biol Reprod (Paris); 2007 Oct;36(6):602-6
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  • The metastatic involvement of the breast from non-mammary neoplasms is a relatively rare condition: 0.5 to 6% of the breast cancers.
  • The search for a primitive tumor is essential, in particular for neuroendocrine carcinoma, stromal sarcoma, and the angiosarcoma which can be primitive tumors of the breast.

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  • (PMID = 17590284.001).
  • [ISSN] 0368-2315
  • [Journal-full-title] Journal de gynécologie, obstétrique et biologie de la reproduction
  • [ISO-abbreviation] J Gynecol Obstet Biol Reprod (Paris)
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 17
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51. Ishibashi N, Mitachi Y, Sugawara S, Shinozaki S, Miura M, Fukuju T, Katahira Y, Koyama K, Fujikawa N, Kato T, Murakami K: [A case of cardiac angiosarcoma successfully treated with docetaxel]. Gan To Kagaku Ryoho; 2007 Nov;34(11):1849-52
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  • [Title] [A case of cardiac angiosarcoma successfully treated with docetaxel].
  • We report a case of angiosarcoma of the right atrium presenting superior vena cava syndrome.
  • The pathological diagnosis was angiosarcoma.
  • The patient agreed to chemotherapy with docetaxel, which is known to be often effective against angiosarcoma of the scalp or face.
  • The tumor, however, became resistant to docetaxel and formed metastatic involvements in the liver.
  • An effective treatment for cardiac angiosarcoma has not yet been established.
  • Chemotherapy with docetaxel should be considered in the treatment of patients with cardiac angiosarcoma.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Heart Neoplasms / drug therapy. Hemangiosarcoma / drug therapy. Taxoids / therapeutic use

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  • (PMID = 18030022.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Taxoids; 15H5577CQD / docetaxel
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52. Nicolas MM, Nayar R, Yeldandi A, De Frias DV: Pulmonary metastasis of a postradiation breast epithelioid angiosarcoma mimicking adenocarcinoma. A case report. Acta Cytol; 2006 Nov-Dec;50(6):672-6
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  • [Title] Pulmonary metastasis of a postradiation breast epithelioid angiosarcoma mimicking adenocarcinoma. A case report.
  • BACKGROUND: Epithelioid angiosarcoma (EAS) is a mesenchymal neoplasm that may appear indistinguishable from carcinoma, melanoma and other tumors with epithelioid/epithelial differentiation.
  • We report a case of metastatic postradiation EAS to the lungs that was mistaken for adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / pathology. Breast Neoplasms / pathology. Carcinoma, Intraductal, Noninfiltrating / radiotherapy. Hemangiosarcoma / secondary. Lung Neoplasms / secondary. Neoplasms, Radiation-Induced / pathology. Radiotherapy / adverse effects


53. Neragi-Miandoab S, Kim J, Vlahakes GJ: Malignant tumours of the heart: a review of tumour type, diagnosis and therapy. Clin Oncol (R Coll Radiol); 2007 Dec;19(10):748-56
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  • Primary cardiac neoplasms are rare and occur less commonly than metastatic disease of the heart.
  • Sarcomas are the most common cardiac tumours and include myxosarcoma, liposarcoma, angiosarcoma, fibrosarcoma, leiomyosarcoma, osteosarcoma, synovial sarcoma, rhabdomyosarcoma, neurofibrosarcoma, malignant fibrous histiocytoma and undifferentiated sarcoma.

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  • (PMID = 17693068.001).
  • [ISSN] 0936-6555
  • [Journal-full-title] Clinical oncology (Royal College of Radiologists (Great Britain))
  • [ISO-abbreviation] Clin Oncol (R Coll Radiol)
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 77
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54. Ikeya E, Taguchi J, Yamaguchi M, Shibuya M, Kanabuchi K: Primary cardiac angiosarcoma: presenting with cardiac tamponade followed by cerebral hemorrhage with brain metastases. Jpn J Thorac Cardiovasc Surg; 2006 Dec;54(12):528-31
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  • [Title] Primary cardiac angiosarcoma: presenting with cardiac tamponade followed by cerebral hemorrhage with brain metastases.
  • Pathology examination of samples at pericardiotomy revealed them to be angiosarcoma.
  • Primary cardiac angiosarcoma is rare, and mostly arises from the right side of the heart.
  • Common metastatic sites are the lungs and liver.
  • In conclusion, this is a rare report of cardiac angiosarcoma presenting with pericardial tamponade.
  • [MeSH-major] Brain Neoplasms / complications. Brain Neoplasms / secondary. Cardiac Tamponade / etiology. Cerebral Hemorrhage / etiology. Heart Neoplasms / pathology. Hemangiosarcoma / pathology

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  • (PMID = 17236655.001).
  • [ISSN] 1344-4964
  • [Journal-full-title] The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai zasshi
  • [ISO-abbreviation] Jpn. J. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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55. Aviles-Salas A, Luévano-González A: [Primary angiosarcoma of the spleen: report of one case]. Rev Med Chil; 2007 Sep;135(9):1178-81
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  • [Title] [Primary angiosarcoma of the spleen: report of one case].
  • [Transliterated title] Angiosarcoma primario del bazo: Caso clínico.
  • Primary angiosarcoma of the spleen is rare and almost always fatal.
  • It has an aggressive behavior and frequently presents with hematological abnormalities or metastatic disease.
  • He was subjected to a splenectomy and the biopsy disclosed an angiosarcoma of the spleen.
  • [MeSH-major] Hemangiosarcoma / pathology. Splenic Neoplasms / pathology

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  • (PMID = 18064374.001).
  • [ISSN] 0034-9887
  • [Journal-full-title] Revista médica de Chile
  • [ISO-abbreviation] Rev Med Chil
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Chile
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56. Fujii T, Zen Y, Sato Y, Sasaki M, Enomae M, Minato H, Masuda S, Uehara T, Katsuyama T, Nakanuma Y: Podoplanin is a useful diagnostic marker for epithelioid hemangioendothelioma of the liver. Mod Pathol; 2008 Feb;21(2):125-30
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  • In this study, we examined podoplanin expression in specimens from 10 normal livers and 73 cases of liver tumors: hemangioma (16 cases), epithelioid hemangioendothelioma (9 cases), angiosarcoma (4 cases), angiomyolipoma (7 cases), hepatocellular carcinoma (11 cases), intrahepatic cholangiocarcinoma (11 cases), and metastatic liver cancer (15 cases).
  • The expression of CD31, CD34, and factor VIII was observed in endothelial cells in all cases of hemangioma, epithelioid hemangioendothelioma, angiosarcoma, and angiomyolipoma with one exception, a case of epithelioid hemangioendothelioma which was without CD31 expression.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Angiomyolipoma / metabolism. Angiomyolipoma / pathology. Bile Duct Neoplasms / metabolism. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / metabolism. Bile Ducts, Intrahepatic / pathology. Carcinoma, Hepatocellular / metabolism. Carcinoma, Hepatocellular / pathology. Cholangiocarcinoma / metabolism. Cholangiocarcinoma / pathology. Diagnosis, Differential. Endothelium, Lymphatic / metabolism. Endothelium, Lymphatic / pathology. Female. Hemangioma / metabolism. Hemangioma / pathology. Hemangiosarcoma / metabolism. Hemangiosarcoma / pathology. Humans. Liver / metabolism. Liver / pathology. Male. Middle Aged

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  • (PMID = 18084256.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Membrane Glycoproteins; 0 / PDPN protein, human
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57. Donghi D, Kerl K, Dummer R, Schoenewolf N, Cozzio A: Cutaneous angiosarcoma: own experience over 13 years. Clinical features, disease course and immunohistochemical profile. J Eur Acad Dermatol Venereol; 2010 Oct;24(10):1230-4
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  • [Title] Cutaneous angiosarcoma: own experience over 13 years. Clinical features, disease course and immunohistochemical profile.
  • BACKGROUND: Cutaneous angiosarcoma (AS) is a rare malignant tumour of endothelial origin with very poor prognosis, frequent recurrences and high metastatic potential.
  • [MeSH-major] Hemangiosarcoma / diagnosis. Hemangiosarcoma / pathology. Skin Neoplasms / diagnosis. Skin Neoplasms / pathology

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  • (PMID = 20236193.001).
  • [ISSN] 1468-3083
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / monoclonal antibody D2-40
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58. Scholsem M, Raket D, Flandroy P, Sciot R, Deprez M: Primary temporal bone angiosarcoma: a case report. J Neurooncol; 2005 Nov;75(2):121-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary temporal bone angiosarcoma: a case report.
  • We present a rare case of temporal bone angiosarcoma diagnosed in a 26-year-old female patient at 36 week of pregnancy.
  • Pathological findings were those of a poorly differentiated, highly malignant sarcoma with a large epitheloid component and immunohistochemical evidence of endothelial differentiation (CD31, Factor VIII related antigen, CD34), consistent with an angiosarcoma with epitheloid features.
  • Despite an initial good response, she died with metastatic disease 26 months after diagnosis.
  • We present a rare case of primary temporal bone angiosarcoma and report our experience with a multimode therapeutic approach combining surgery, radiotherapy and chemotherapy.
  • [MeSH-major] Hemangiosarcoma / diagnosis. Pregnancy Complications, Neoplastic / diagnosis. Skull Neoplasms / diagnosis. Skull Neoplasms / pathology. Temporal Bone

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  • (PMID = 16132518.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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59. Emberger M, Laimer M, Steiner H, Zelger B: Retiform hemangioendothelioma: presentation of a case expressing D2-40. J Cutan Pathol; 2009 Sep;36(9):987-90
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  • Retiform hemangioendothelioma (RH) is a low-grade angiosarcoma with low metastatic risk, usually occurring as a single lesion on the trunk or extremity in middle-aged adults.

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  • (PMID = 19674202.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Biomarkers, Tumor; 0 / monoclonal antibody D2-40
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60. Nord KM, Kandel J, Lefkowitch JH, Lobritto SJ, Morel KD, North PE, Garzon MC: Multiple cutaneous infantile hemangiomas associated with hepatic angiosarcoma: case report and review of the literature. Pediatrics; 2006 Sep;118(3):e907-13
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  • [Title] Multiple cutaneous infantile hemangiomas associated with hepatic angiosarcoma: case report and review of the literature.
  • Histopathologic evaluation of the liver revealed a diagnosis of type 2 infantile hepatic hemangioendothelioma (regarded as synonymous with angiosarcoma) rather than benign infantile hemangioma of the liver.
  • Subsequent skin biopsies confirmed that her multiple cutaneous lesions were infantile hemangiomas and not metastatic angiosarcoma.
  • We report this case and a review of the literature on pediatric angiosarcoma of the liver associated with cutaneous infantile hemangiomas.
  • [MeSH-major] Hemangioma / pathology. Hemangiosarcoma / pathology. Liver Neoplasms / pathology. Skin Neoplasms / pathology

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  • [ErratumIn] Pediatrics. 2007 Jun;119(6):1271
  • (PMID = 16880251.001).
  • [ISSN] 1098-4275
  • [Journal-full-title] Pediatrics
  • [ISO-abbreviation] Pediatrics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 27
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61. Sebenik M, Ricci A Jr, DiPasquale B, Mody K, Pytel P, Jee KJ, Knuutila S, Scholes J: Undifferentiated intimal sarcoma of large systemic blood vessels: report of 14 cases with immunohistochemical profile and review of the literature. Am J Surg Pathol; 2005 Sep;29(9):1184-93
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  • The distinctive histopathologic appearance of the primary luminal lesion was lost whenever tumor invaded outside the vessel wall (into adventitia and beyond) or in metastatic sites.
  • Such extravascular tumors assumed a variety of patterns reminiscent of undifferentiated pleomorphic sarcoma (UPS; in older literature also known as pleomorphic malignant fibrous histiocytoma, MFH) or other distinct types of sarcomas, including osteosarcoma, angiosarcoma, and rhabdomyosarcoma.

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  • (PMID = 16096408.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / FLII protein, human; 0 / Gelsolin; 0 / Microfilament Proteins; 0 / Receptors, Cytoplasmic and Nuclear
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62. Böge G, Gallix B, Gresillon C, Khau Van Kien A, Veerapen R, Quéré I: [Primary angiosarcoma of the aorta]. Vasa; 2007 Feb;36(1):33-40
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  • [Title] [Primary angiosarcoma of the aorta].
  • [Transliterated title] Primäres Angiosarkom der Aorta.
  • Primary angiosarcoma of the aorta is a rare disease.
  • The prognosis is poor, resulting of embolic complications and early metastatic disease, with a median survival of nine months.
  • We report the case of a 68-year-old woman referred for a thrombosis of the superior mesenteric artery, occurring a few weeks after resection of an angiosarcoma of the small intestine, disclosing a primary angiosarcoma of the aortic wall with metastatic disease.
  • [MeSH-major] Aorta, Thoracic. Aortic Diseases / diagnosis. Hemangiosarcoma / diagnosis. Mesenteric Artery, Superior. Mesenteric Vascular Occlusion / etiology. Thrombosis / etiology. Vascular Neoplasms / diagnosis

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  • (PMID = 17323296.001).
  • [ISSN] 0301-1526
  • [Journal-full-title] VASA. Zeitschrift für Gefässkrankheiten
  • [ISO-abbreviation] VASA
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 34
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63. Lahat G, Dhuka AR, Hallevi H, Xiao L, Zou C, Smith KD, Phung TL, Pollock RE, Benjamin R, Hunt KK, Lazar AJ, Lev D: Angiosarcoma: clinical and molecular insights. Ann Surg; 2010 Jun;251(6):1098-106
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  • [Title] Angiosarcoma: clinical and molecular insights.
  • OBJECTIVE: Angiosarcoma (AS) is a rare understudied soft tissue sarcoma exhibiting endothelial cell differentiation.
  • RESULTS: Forty-three (19.4%) metastatic AS patients and 179 patients (80.6%) with localized disease were included.
  • Median survival of localized versus metastatic AS was 49 (range, 2-188) versus 10 (range, 1-69) months (P < 0.0001).
  • [MeSH-major] Hemangiosarcoma / mortality

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  • (PMID = 20485141.001).
  • [ISSN] 1528-1140
  • [Journal-full-title] Annals of surgery
  • [ISO-abbreviation] Ann. Surg.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01 CA138345
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Benzamides; 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / EIF4EBP1 protein, human; 0 / ELF4 protein, human; 0 / Phosphoproteins; 0 / Transcription Factors; 0 / Vascular Endothelial Growth Factor A; 82558-50-7 / isoxaben; EC 2.7.- / Phosphotransferases; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt
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64. Conde-Taboada A, Flórez A, De la Torre C, Feal C, García-Doval I, Cruces M: Pseudoangiosarcomatous squamous cell carcinoma of skin arising adjacent to decubitus ulcers. Am J Dermatopathol; 2005 Apr;27(2):142-4
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  • Pseudoangiosarcomatous, or pseudovascular, squamous cell carcinoma of skin is an unusual form of acantholytic (adenoid, pseudoglandular) squamous cell carcinoma that mimics the histolopathologic appearance of angiosarcoma.
  • The histopathologic examination of a wedge biopsy specimen revealed infiltrative cords of neoplastic cells that formed interanastomosing channels imitating angiosarcoma.
  • Because of metastatic disease, palliative measures were undertaken and the patient died four months later.
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Hemangiosarcoma / pathology. Humans. Immunohistochemistry

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  • (PMID = 15798440.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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65. Valbuena JR, Levenback C, Mansfield P, Liu J: Angiosarcoma of the spleen clinically presenting as metastatic ovarian cancer. A case report and review of the literature. Ann Diagn Pathol; 2005 Oct;9(5):289-92
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  • [Title] Angiosarcoma of the spleen clinically presenting as metastatic ovarian cancer. A case report and review of the literature.
  • The differential diagnosis includes a variety of benign and malignant vascular proliferations (littoral cell angioma and Kaposi's sarcoma) as well as metastatic tumors.
  • We report a case of the 43-year-old woman with a long-standing history of recurrent ovarian carcinoma treated with surgery and multiple courses of radiation therapy and chemotherapy who clinically appeared to have a metastatic ovarian cancer to the spleen and treated with partial resection of stomach and splenectomy.
  • However, histopathologic examination of the specimen showed the tumor to be of a primary angiosarcoma.
  • [MeSH-major] Hemangiosarcoma / pathology. Neoplasms, Second Primary / pathology. Ovarian Neoplasms / pathology. Splenic Neoplasms / pathology


66. Gamlem H, Nordstoga K, Arnesen K: Canine vascular neoplasia--a population-based clinicopathologic study of 439 tumours and tumour-like lesions in 420 dogs. APMIS Suppl; 2008;(125):41-54
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  • Clinical behaviour, comprising recurrence and metastatic disposition, is included.
  • Dissemination involved a further 23 cases (22 had angiosarcoma).
  • [MeSH-minor] Animals. Dogs. Female. Hemangioma / pathology. Hemangioma / veterinary. Hemangiosarcoma / pathology. Hemangiosarcoma / veterinary. Lymphangioma / pathology. Lymphangioma / veterinary. Male

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  • (PMID = 19385280.001).
  • [ISSN] 0903-465X
  • [Journal-full-title] APMIS. Supplementum
  • [ISO-abbreviation] APMIS Suppl.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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67. Ravi V, Benjamin RS: Systemic therapy for cardiac sarcomas. Methodist Debakey Cardiovasc J; 2010 Jul-Sep;6(3):57-60
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  • Cardiac sarcomas create 2 risks: local problems and metastatic disease.
  • Most frequently, the histologies are angiosarcoma and high-grade pleomorphic unclassified sarcoma (formerly called MFH or malignant fibrous histiocytoma).
  • Attempts to concentrate on the local problem only with therapies up to and including cardiac transplantation have been unsuccessful due to the high rate of fatal metastatic disease.

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  • (PMID = 20834213.001).
  • [ISSN] 1947-6094
  • [Journal-full-title] Methodist DeBakey cardiovascular journal
  • [ISO-abbreviation] Methodist Debakey Cardiovasc J
  • [Language] eng
  • [Publication-type] Journal Article; Portraits
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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68. Gatcombe HG, Olson TA, Esiashvili N: Metastatic primary angiosarcoma of the breast in a pediatric patient with a complete response to systemic chemotherapy and definitive radiation therapy: case report and review of the literature. J Pediatr Hematol Oncol; 2010 Apr;32(3):192-4
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  • [Title] Metastatic primary angiosarcoma of the breast in a pediatric patient with a complete response to systemic chemotherapy and definitive radiation therapy: case report and review of the literature.
  • We present a case of a rare malignancy, primary breast angiosarcoma, in a 15-year-old girl.
  • She presented with a locally advanced tumor and suspected metastatic disease to the mediastinum and bones on PET imaging.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bone Neoplasms / therapy. Breast Neoplasms / therapy. Hemangiosarcoma / therapy. Mediastinal Neoplasms / therapy. Radiotherapy

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  • (PMID = 20186104.001).
  • [ISSN] 1536-3678
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; UM20QQM95Y / Ifosfamide
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69. Vorburger SA, Xing Y, Hunt KK, Lakin GE, Benjamin RS, Feig BW, Pisters PW, Ballo MT, Chen L, Trent J 3rd, Burgess M, Patel S, Pollock RE, Cormier JN: Angiosarcoma of the breast. Cancer; 2005 Dec 15;104(12):2682-8
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  • [Title] Angiosarcoma of the breast.
  • BACKGROUND: Angiosarcoma of the breast is a rare entity.
  • METHODS: Clinical and pathologic factors were analyzed in all patients with angiosarcoma of the breast treated between 1990 and 2003.
  • RESULTS: Fifty-five women with angiosarcoma of the breast were identified.
  • For the 32 patients with primary angiosarcoma of the breast 5-year OS was 59%.
  • These patients with radiation therapy-associated angiosarcoma were on average 30 years older and less likely to present with distant metastatic disease than patients presenting with radiation-naive angiosarcoma of the breast.
  • CONCLUSIONS: In this series of 55 patients with angiosarcoma of the breast, radiation therapy-naive angiosarcomas occurred in younger patients, but they behaved similarly to radiation therapy-associated angiosarcomas.
  • [MeSH-major] Breast Neoplasms / mortality. Breast Neoplasms / therapy. Hemangiosarcoma / mortality. Hemangiosarcoma / therapy. Mastectomy / methods

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  • [Copyright] Copyright 2005 American Cancer Society.
  • (PMID = 16288486.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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70. Lau OD, Bhuta S, Smart CN, Kirsch CM, St John MA: Radiology quiz case 1. Metastatic cutaneous angiosarcoma of the scalp with perineural spread. Arch Otolaryngol Head Neck Surg; 2010 Apr;136(4):411; 413
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  • [Title] Radiology quiz case 1. Metastatic cutaneous angiosarcoma of the scalp with perineural spread.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Hemangiosarcoma / radiography. Hemangiosarcoma / secondary. Scalp. Skin Neoplasms / pathology

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  • (PMID = 20403861.001).
  • [ISSN] 1538-361X
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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71. Wedmid A, Masterson TA, Maki RG, Russo P: A case of high-risk penile epithelioid hemangioendothelioma. Nat Rev Urol; 2009 Apr;6(4):223-7
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  • Following the results of a biopsy, multifocal angiosarcoma was diagnosed.
  • CT of the chest, abdomen and pelvis was negative for metastatic disease.

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  • (PMID = 19352397.001).
  • [ISSN] 1759-4820
  • [Journal-full-title] Nature reviews. Urology
  • [ISO-abbreviation] Nat Rev Urol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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72. Qi XP, Lin GB, Zhu YL, Wang JQ, Dai XW, Ma JM, Yan L: [Pseudoangiosarcomatous squamous cell carcinoma of the penis: a case report with clinicopathological and human papilloma virus analyses]. Zhonghua Nan Ke Xue; 2009 Feb;15(2):134-9
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  • HPV DNA (HPVpan, HPV6B/11, HPV16/18, HPV31/33) was not detected by in situ hybridization in the primary and metastatic tumors.
  • CONCLUSION: PASCC is a specific and extremely rare subtype of penile SCC with dramatic similarity to angiosarcoma under the microscope, with poor prognosis.


73. Husted TL, Neff G, Thomas MJ, Gross TG, Woodle ES, Buell JF: Liver transplantation for primary or metastatic sarcoma to the liver. Am J Transplant; 2006 Feb;6(2):392-7
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  • [Title] Liver transplantation for primary or metastatic sarcoma to the liver.
  • Sarcoma is generally a rare disease in the US, with poor survival in patients with both primary angiosarcoma and metastatic disease from sarcoma and GIST.
  • Those patients with liver failure from primary or metastatic liver sarcoma were evaluated.
  • 19 patients are identified having received liver transplantation after treatment for sarcoma of the liver, 6 patients with primary hepatic sarcoma and 13 patients with metastatic sarcoma of the liver.
  • Given the early recurrence of tumor and meager 1-year survival outcome, liver transplantation is a poor therapeutic choice for patients with either primary or metastatic liver sarcoma, including high-grade leiomyosarcoma (GIST) regardless of primary site or primary therapy.


74. Hsu JT, Lin CY, Wu TJ, Chen HM, Hwang TL, Jan YY: Splenic angiosarcoma metastasis to small bowel presented with gastrointestinal bleeding. World J Gastroenterol; 2005 Nov 7;11(41):6560-2
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  • [Title] Splenic angiosarcoma metastasis to small bowel presented with gastrointestinal bleeding.
  • Primary splenic angiosarcoma is a very rare, aggressive neoplasm with a high metastatic rate and dismal prognosis.
  • Splenic angiosarcoma with bleeding gastrointestinal metastases is extremely rare.
  • This study reported a 44-year-old male patient with splenic angiosarcoma with sustained repeated gastrointestinal bleeding due to small bowel metastases.
  • Salvage surgery was performed by splenectomy and resection of the metastatic small bowel tumors.
  • [MeSH-major] Gastrointestinal Hemorrhage / etiology. Hemangiosarcoma / secondary. Intestinal Neoplasms / secondary. Splenic Neoplasms / pathology

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  • (PMID = 16425436.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4355806
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75. Asmane I, Litique V, Heymann S, Marcellin L, Métivier AC, Duclos B, Bergerat JP, Kurtz JE: Adriamycin, cisplatin, ifosfamide and paclitaxel combination as front-line chemotherapy for locally advanced and metastatic angiosarcoma. Analysis of three case reports and review of the literature. Anticancer Res; 2008 Sep-Oct;28(5B):3041-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adriamycin, cisplatin, ifosfamide and paclitaxel combination as front-line chemotherapy for locally advanced and metastatic angiosarcoma. Analysis of three case reports and review of the literature.
  • Angiosarcoma represents 1 to 2% of soft tissue tumors.
  • The outcome of angiosarcoma is poor for those patients in whom aggressive surgery cannot be considered.
  • We report three cases of angiosarcoma in which first-line chemotherapy with adriamycin 40 mg/m2 day 1, ifosfamide 3 g/m2 day 1-2, cisplatin 35 mg/m2 day 1-2 and paclitaxel 175 mg/m2 day 3 led to clinically meaningful responses.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bone Neoplasms / drug therapy. Breast Neoplasms / drug therapy. Hemangiosarcoma / drug therapy. Soft Tissue Neoplasms / drug therapy

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  • (PMID = 19031953.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 80168379AG / Doxorubicin; P88XT4IS4D / Paclitaxel; Q20Q21Q62J / Cisplatin; UM20QQM95Y / Ifosfamide
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76. Marthya A, Patinharayil G, Puthezeth K, Sreedharan S, Kumar A, Kumaran CM: Multicentric epithelioid angiosarcoma of the spine: a case report of a rare bone tumor. Spine J; 2007 Nov-Dec;7(6):716-9
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  • [Title] Multicentric epithelioid angiosarcoma of the spine: a case report of a rare bone tumor.
  • BACKGROUND CONTEXT: Epithelioid angiosarcoma (EA) is a high-grade sarcoma of vascular origin.
  • EA is a rare variant of angiosarcoma.
  • The authors point out the need for immunohistochemical evaluation after careful histological analysis for vascular differentiation for an accurate diagnosis of vascular bone tumors with epithelioid features so that an erroneous diagnosis of metastatic carcinoma can be avoided.
  • [MeSH-major] Bone Neoplasms / pathology. Epithelioid Cells / pathology. Hemangiosarcoma / pathology. Magnetic Resonance Imaging. Thoracic Vertebrae / pathology

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  • (PMID = 17998131.001).
  • [ISSN] 1529-9430
  • [Journal-full-title] The spine journal : official journal of the North American Spine Society
  • [ISO-abbreviation] Spine J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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77. Hejmadi RK, Walker C, Rashid A, Marsden JR: Radiation-induced angiosarcoma following treatment of metastatic melanoma. J Cutan Pathol; 2009 Nov;36(11):1229-31
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  • [Title] Radiation-induced angiosarcoma following treatment of metastatic melanoma.
  • [MeSH-major] Hemangiosarcoma / etiology. Hemangiosarcoma / pathology. Neoplasms, Radiation-Induced / pathology. Soft Tissue Neoplasms / etiology. Soft Tissue Neoplasms / pathology

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  • (PMID = 19615010.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Denmark
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78. Berretta M, Rupolo M, Buonadonna A, Canzonieri V, Brollo A, Morra A, Berretta S, Bearz A, Tirelli U, Frustaci S: Metastatic angiosarcoma of the kidney: a case report with treatment approach and review of the literature. J Chemother; 2006 Apr;18(2):221-4
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  • [Title] Metastatic angiosarcoma of the kidney: a case report with treatment approach and review of the literature.
  • We report the case of a 67-year-old man affected by a large angiosarcoma of the kidney.
  • [MeSH-major] Hemangiosarcoma / drug therapy. Hemangiosarcoma / surgery. Kidney Neoplasms / drug therapy. Kidney Neoplasms / surgery

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  • (PMID = 16736893.001).
  • [ISSN] 1120-009X
  • [Journal-full-title] Journal of chemotherapy (Florence, Italy)
  • [ISO-abbreviation] J Chemother
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Anthracyclines; UM20QQM95Y / Ifosfamide
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79. Horn LC, Liebert UG, Edelmann J, Höckel M, Einenkel J: Adenoid squamous carcinoma (pseudoangiosarcomatous carcinoma) of the vulva: a rare but highly aggressive variant of squamous cell carcinoma-report of a case and review of the literature. Int J Gynecol Pathol; 2008 Apr;27(2):288-91
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  • Pseudoangiosarcomatous squamous cell carcinoma is an unusual but aggressive variant of acantholytic squamous cell carcinoma of the vulva that mimics angiosarcoma on histology.
  • We present a case of a 57-year-old woman with bilateral inguinal metastatic disease at the time of diagnosis, who died 4 months later because of distant metastatic disease to the lungs.
  • [MeSH-minor] Diagnosis, Differential. Female. Hemangiosarcoma / diagnosis. Hemangiosarcoma / metabolism. Hemangiosarcoma / pathology. Humans. Middle Aged. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 18317210.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Tumor Suppressor Protein p53
  • [Number-of-references] 16
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81. Guirguis A, Kanbour-Shakir A, Kelley J: Epithelioid angiosarcoma of the mons after chemoradiation for vulvar cancer. Int J Gynecol Pathol; 2007 Jul;26(3):265-8
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  • [Title] Epithelioid angiosarcoma of the mons after chemoradiation for vulvar cancer.
  • Our patient is the first case report of an angiosarcoma of the mons pubis after chemoradiation and the second reported angiosarcoma of the mons.
  • She presented 4 years later with a lesion on her mons, consistent with an angiosarcoma.
  • Our patient is the first case report of an angiosarcoma of the mons pubis after chemoradiation for vulvar cancer and the second reported angiosarcoma of the mons.
  • She currently is undergoing systemic chemotherapy after being diagnosed with a metastatic pelvic lymph node.
  • [MeSH-major] Hemangiosarcoma / pathology. Vulvar Neoplasms / pathology

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  • (PMID = 17581409.001).
  • [ISSN] 0277-1691
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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82. Lahat G, Dhuka AR, Lahat S, Smith KD, Pollock RE, Hunt KK, Ravi V, Lazar AJ, Lev D: Outcome of locally recurrent and metastatic angiosarcoma. Ann Surg Oncol; 2009 Sep;16(9):2502-9
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  • [Title] Outcome of locally recurrent and metastatic angiosarcoma.
  • BACKGROUND: Angiosarcoma (AS) is a rare soft tissue sarcoma with an enhanced propensity for local and systemic failure.
  • The outcome of locally recurrent and metastatic AS treated at a single institution was evaluated.
  • Ninety-nine patients were treated for metastatic AS; 73% had multiple metastatic sites; the lung was the most common site (36%).
  • In contrast, metastatic patients have a grave prognosis; however, patients with isolated lymphatic spread and possibly those treated with taxol-based chemotherapeutic regimens have a favorable outcome.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Hemangiosarcoma / secondary. Neoplasm Recurrence, Local / pathology. Neoplasms / pathology

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  • (PMID = 19551444.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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83. Guillou L, Aurias A: Soft tissue sarcomas with complex genomic profiles. Virchows Arch; 2010 Feb;456(2):201-17
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  • Soft tissue sarcomas (STS) with complex genomic profiles (50% of all STS) are predominantly composed of spindle cell/pleomorphic sarcomas, including leiomyosarcoma, myxofibrosarcoma, pleomorphic liposarcoma, pleomorphic rhabdomyosarcoma, malignant peripheral nerve sheath tumor, angiosarcoma, extraskeletal osteosarcoma, and spindle cell/pleomorphic unclassified sarcoma (previously called spindle cell/pleomorphic malignant fibrous histiocytoma).
  • Many of them share recurrent aberrations (e.g., gain of 5p13-p15) that seem to play a significant role in tumor progression and/or metastatic dissemination.

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  • (PMID = 20217954.001).
  • [ISSN] 1432-2307
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / DNA, Neoplasm
  • [Number-of-references] 109
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84. Penel N, Bui BN, Bay JO, Cupissol D, Ray-Coquard I, Piperno-Neumann S, Kerbrat P, Fournier C, Taieb S, Jimenez M, Isambert N, Peyrade F, Chevreau C, Bompas E, Brain EG, Blay JY: Phase II trial of weekly paclitaxel for unresectable angiosarcoma: the ANGIOTAX Study. J Clin Oncol; 2008 Nov 10;26(32):5269-74
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  • [Title] Phase II trial of weekly paclitaxel for unresectable angiosarcoma: the ANGIOTAX Study.
  • PURPOSE: The objective of this phase II trial was to assess the efficacy and toxicity of weekly paclitaxel for patients with metastatic or unresectable angiosarcoma.
  • Three patients with locally advanced breast angiosarcoma presented partial response, which enabled a secondary curative-intent surgery with complete histologic response in two cases.
  • [MeSH-major] Antineoplastic Agents, Phytogenic / administration & dosage. Breast Neoplasms / drug therapy. Head and Neck Neoplasms / drug therapy. Hemangiosarcoma / drug therapy. Paclitaxel / administration & dosage. Scalp. Skin Neoplasms / drug therapy. Soft Tissue Neoplasms / drug therapy

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  • (PMID = 18809609.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; P88XT4IS4D / Paclitaxel
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85. Koutelidakis IM, Tsiaousis PZ, Papaziogas BT, Patsas AG, Atmatzidis SK, Atmatzidis KS: Spleen rupture due to primary angiosarcoma: a case report. J Gastrointest Cancer; 2007;38(2-4):74-7
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  • [Title] Spleen rupture due to primary angiosarcoma: a case report.
  • A case of a 79-year-old female with rupture of the spleen due to primary angiosarcoma is presented.
  • Primary angiosarcoma of the spleen is a very rare and aggressive neoplasm with a high metastatic rate and almost uniformly fatal.
  • [MeSH-major] Hemangiosarcoma / complications. Splenic Neoplasms / complications. Splenic Rupture / etiology

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  • (PMID = 19016352.001).
  • [ISSN] 1941-6628
  • [Journal-full-title] Journal of gastrointestinal cancer
  • [ISO-abbreviation] J Gastrointest Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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86. Bien E, Stachowicz-Stencel T, Balcerska A, Godzinski J, Kazanowska B, Perek-Polnik M, Madziara W, Rybczynska A, Kurylak A, Zalewska-Szewczyk B, Peregud-Pogorzelski J: Angiosarcoma in children - still uncontrollable oncological problem. The report of the Polish Paediatric Rare Tumours Study. Eur J Cancer Care (Engl); 2009 Jul;18(4):411-20
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  • [Title] Angiosarcoma in children - still uncontrollable oncological problem. The report of the Polish Paediatric Rare Tumours Study.
  • Angiosarcoma in children - still uncontrollable oncological problem.
  • Ten children with angiosarcoma (M/F: 6/4; aged 2, 3-16 years) registered in Polish Paediatric Rare Tumours and Soft Tissue Sarcomas Studies between 1992 and 2006.
  • Four patients had regional and two metastatic diseases (lungs and bones).
  • Seven patients experienced relapses (mainly metastatic) and two continuous progression.
  • Angiosarcoma in children is highly aggressive with an extremely poor prognosis.
  • The response to chemotherapy is poor and the large number of metastatic recurrences suggests a need for systemic therapy modifications.
  • [MeSH-major] Hemangiosarcoma / pathology. Hemangiosarcoma / therapy. Sarcoma / pathology. Sarcoma / therapy

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  • (PMID = 19490008.001).
  • [ISSN] 1365-2354
  • [Journal-full-title] European journal of cancer care
  • [ISO-abbreviation] Eur J Cancer Care (Engl)
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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87. Hoti E, Adam R: Liver transplantation for primary and metastatic liver cancers. Transpl Int; 2008 Dec;21(12):1107-17
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  • [Title] Liver transplantation for primary and metastatic liver cancers.
  • Epithelioid hemangioendothelioma is also an appropriate indication for liver transplantation, even in the presence of extrahepatic metastases, unlike angiosarcoma which is associated with a very poor survival and considered as a contraindication.
  • And finally for metastatic liver disease from neuroendocrine tumours, liver transplantation can result in long-term survival and even cure in well selected patients.
  • [MeSH-minor] Bile Duct Neoplasms / surgery. Carcinoma, Hepatocellular / pathology. Carcinoma, Hepatocellular / surgery. Cholangiocarcinoma / surgery. Colorectal Neoplasms / pathology. Hemangioendothelioma / surgery. Hemangiosarcoma / surgery. Humans. Neoplasm Metastasis. Neoplasm Staging. Neuroendocrine Tumors / surgery. Survival Analysis. Survivors. Treatment Outcome

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  • (PMID = 18713148.001).
  • [ISSN] 0934-0874
  • [Journal-full-title] Transplant international : official journal of the European Society for Organ Transplantation
  • [ISO-abbreviation] Transpl. Int.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 75
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88. Plaza JA, Torres-Cabala C, Evans H, Diwan HA, Suster S, Prieto VG: Cutaneous metastases of malignant melanoma: a clinicopathologic study of 192 cases with emphasis on the morphologic spectrum. Am J Dermatopathol; 2010 Apr;32(2):129-36
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  • Metastatic melanoma represents one of the most common types of cutaneous metastases.
  • In up to 5% of patients, metastatic melanoma can be the first manifestation of the disease.
  • For the most part, the histologic diagnosis of metastatic melanoma poses little diagnostic difficulty; however, some metastases may adopt unusual or unfamiliar appearances mimicking other benign and malignant conditions.
  • We present a study of 192 cases of cutaneous metastatic melanomas with special emphasis on their spectrum of morphologic features.
  • The histologic diagnosis of cutaneous metastatic melanoma can pose difficulties for diagnosis, especially in the face of an unknown primary neoplasm.
  • Unusual features observed in this series included examples of cutaneous metastatic melanoma that closely simulated metastatic carcinoma, dermatofibroma, leiomyosarcoma, angiosarcoma, nevoid melanoma, halo nevus, blue nevi, and atypical fibroxanthoma.
  • Our series illustrates that the differential diagnosis of cutaneous metastatic melanoma can be broad and difficult.
  • To the best of our knowledge, this is the largest series of cutaneous metastatic melanomas reported in the literature.

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  • (PMID = 20010406.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD34; 0 / Antigens, Differentiation, Myelomonocytic; 0 / Antigens, Neoplasm; 0 / CD68 antigen, human; 0 / Desmin; 0 / Ki-67 Antigen; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins
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89. Lund L, Amre R: Epithelioid angiosarcoma involving the lungs. Arch Pathol Lab Med; 2005 Jan;129(1):e7-10
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  • [Title] Epithelioid angiosarcoma involving the lungs.
  • Diffuse lung involvement by metastatic tumor from an unknown primary site often constitutes a diagnostic dilemma.
  • Although cytologic features and pattern of metastatic spread can guide in narrowing the list of possible primary neoplasms, immunohistochemistry remains pivotal in determining the phenotype of metastatic disease.
  • We report a case with extensive involvement of lung parenchyma by a metastatic epithelioid neoplasm exhibiting a variety of distinctive patterns with a predominance of intra-arterial and lymphangitic spread.
  • Electron microscopy of formalin-fixed tissue revealed multiple Weibel-Palade bodies and pinocytosis, supporting the diagnosis of epithelioid angiosarcoma.
  • Doppler studies performed after pathologic diagnosis was rendered demonstrated 2 discrete hypoechoic masses within the medial aspect of the left proximal calf musculature, suggestive of solid soft tissue neoplasm-a possible source of pulmonary metastatic disease.
  • [MeSH-major] Epithelioid Cells / pathology. Hemangiosarcoma / secondary. Lung Neoplasms / secondary. Neoplasms, Unknown Primary / diagnosis

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  • (PMID = 15628928.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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90. Lee TY, Lawen J, Gupta R: Renal angiosarcoma: a case report and literature review. Can J Urol; 2007 Feb;14(1):3471-6
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  • [Title] Renal angiosarcoma: a case report and literature review.
  • A much more rare and aggressive malignant tumor of the kidney is angiosarcoma (AS) with less than 25 cases described internationally.
  • Hematogenous metastatic spread often occurred with median survival time of 3.5 months from time of diagnosis (mean 5.8 months).
  • Histologically, the tumors have classical features of angiosarcoma with numerous blood-filled vascular spaces lined by plump pleomorphic endothelial cells with CD31 and CD34 staining positivity.
  • [MeSH-major] Hemangiosarcoma / diagnosis. Hemangiosarcoma / pathology. Kidney Neoplasms / diagnosis. Kidney Neoplasms / pathology

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  • (PMID = 17324331.001).
  • [ISSN] 1195-9479
  • [Journal-full-title] The Canadian journal of urology
  • [ISO-abbreviation] Can J Urol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Canada
  • [Number-of-references] 28
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91. Canler J, Couraud S, Etienne-Mastroïanni B, Girard N, Benabidallah S, Cordier JF: [Pulmonary metastatic angiosarcoma]. Rev Prat; 2009 Oct 20;59(8):1047
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  • [Title] [Pulmonary metastatic angiosarcoma].
  • [Transliterated title] Angiosarcome métastatique pulmonaire.
  • [MeSH-major] Hemangiosarcoma / pathology. Hemangiosarcoma / secondary. Lung Neoplasms / secondary

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  • (PMID = 19894437.001).
  • [ISSN] 0035-2640
  • [Journal-full-title] La Revue du praticien
  • [ISO-abbreviation] Rev Prat
  • [Language] fre
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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92. Takeuchi K, Deguchi M, Hamana S, Motoyama S, Kitazawa S, Maruo T: A case of postirradiation vaginal angiosarcoma treated with recombinant interleukin-2 therapy. Int J Gynecol Cancer; 2005 Nov-Dec;15(6):1163-5
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  • [Title] A case of postirradiation vaginal angiosarcoma treated with recombinant interleukin-2 therapy.
  • Angiosarcoma of the vagina is an extremely rare neoplasm and is characterized by frequent recurrence and early metastatic spread.
  • We report a case of angiosarcoma of the vagina, in which the diagnosis was made 9 years after intrapelvic irradiation, and recombinant interleukin-2 (rIL-2) therapy could be effective to suppress the development of distant metastasis.
  • We recommend rIL-2 therapy in combination with irradiation as a palliative therapeutic option for vaginal angiosarcoma when the tumor is inoperable or the patient refuses to undergo surgery.
  • Although vaginal angiosarcoma is an extremely rare condition, its possibility should be borne in mind when finding a vaginal mass in a previously irradiated patient.
  • [MeSH-major] Hemangiosarcoma / therapy. Lung Neoplasms / therapy. Neoplasms, Radiation-Induced / etiology. Radiotherapy / adverse effects. Vaginal Neoplasms / therapy

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  • (PMID = 16343203.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Interleukin-2
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93. Kawasaki T, Hen K, Satoh E, Kanno H, Watanabe K, Hasegawa H: Oral presentation of epithelioid angiosarcoma with first sign in the scapula: report of a case and review of the literature. Fukushima J Med Sci; 2005 Dec;51(2):77-85
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  • [Title] Oral presentation of epithelioid angiosarcoma with first sign in the scapula: report of a case and review of the literature.
  • Occurrence of a primary or metastatic angiosarcoma in the oral cavity is extremely rare.
  • The term "epithelioid angiosarcoma" (EA) has been used to designate a morphological variant of angiosarcoma characterized by poorly differentiated epithelial-like cells arranged in carcinoma-like fashion, but which still forms identifiable vascular channels.
  • The oral EA described here almost certainly represents a metastatic focus, rather than the primary site of tumor origin.
  • [MeSH-major] Bone Neoplasms / pathology. Hemangiosarcoma / pathology. Mouth Neoplasms / pathology. Scapula

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  • (PMID = 16555628.001).
  • [ISSN] 0016-2590
  • [Journal-full-title] Fukushima journal of medical science
  • [ISO-abbreviation] Fukushima J Med Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 12
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94. Sher T, Hennessy BT, Valero V, Broglio K, Woodward WA, Trent J, Hunt KK, Hortobagyi GN, Gonzalez-Angulo AM: Primary angiosarcomas of the breast. Cancer; 2007 Jul 1;110(1):173-8
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  • BACKGROUND: The purpose of the study was to describe the clinicopathologic characteristics and clinical outcomes of patients with primary breast angiosarcoma.
  • METHODS: The institutional database was searched to identify breast angiosarcoma patients seen between 1965 and 2002.
  • CONCLUSIONS: Breast angiosarcoma is frequently advanced at diagnosis and has a tendency for local-regional recurrence.
  • A significant number of responses to chemotherapy was observed in the metastatic setting.
  • [MeSH-major] Breast Neoplasms / pathology. Hemangiosarcoma / pathology

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  • [Copyright] Copyright (c) 2007 American Cancer Society.
  • (PMID = 17541936.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / L30 CA123630; United States / NCI NIH HHS / CA / L30 CA123630-01; United States / NCI NIH HHS / CA / L30 CA123630-02
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Estrogen; 0 / Receptors, Progesterone
  • [Other-IDs] NLM/ NIHMS283619; NLM/ PMC4329779
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95. Hofmann UB, Wobser M, Kneitz H, Kleine P, Becker JC, Bröcker EB, Ugurel S: Major response to paclitaxel combined with irradiation as second-line therapy in metastatic angiosarcoma of the face and scalp. Br J Dermatol; 2009 Feb;160(2):456-8
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  • [Title] Major response to paclitaxel combined with irradiation as second-line therapy in metastatic angiosarcoma of the face and scalp.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Head and Neck Neoplasms. Hemangiosarcoma. Scalp

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  • (PMID = 19077074.001).
  • [ISSN] 1365-2133
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 80168379AG / Doxorubicin; P88XT4IS4D / Paclitaxel
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96. Yoo C, Kim JE, Yoon SK, Kim SC, Ahn JH, Kim TW, Suh C, Lee JL: Angiosarcoma of the retroperitoneum: report on a patient treated with sunitinib. Sarcoma; 2009;2009:360875
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  • [Title] Angiosarcoma of the retroperitoneum: report on a patient treated with sunitinib.
  • A 52 year-old woman presented with an incidentally detected retroperitoneal angiosarcoma and multiple hepatic metastases.
  • After chemotherapy with weekly paclitaxel and doxorubicin, angiosarcoma had progressed rapidly.
  • Although sunitinib was interrupted after two weeks due to hematologic abnormalities, some metastatic nodules were regressed.
  • When sunitinib is administered to patients with angiosarcomas, hematologic abnormalities should be monitored frequently as severe hematologic toxicity may be caused either by sunitinib per se or angiosarcoma.

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  • [ISSN] 1357-714X
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  • [ISO-abbreviation] Sarcoma
  • [Language] eng
  • [Publication-type] Journal Article
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97. Masih I, McIlwaine W: Metastatic angiosarcoma: a vascular tumour or an intracranial haemorrhage? BMJ Case Rep; 2010;2010
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  • [Title] Metastatic angiosarcoma: a vascular tumour or an intracranial haemorrhage?
  • Suspected haemorrhages in the past were reported as the metastatic deposits.
  • Biopsy and immunohistochemical staining confirmed angiosarcoma of the scalp.
  • Being vascular tumours, angiosarcoma can mimic a brain haemorrhage.
  • Diagnosing metastatic angiosarcoma of the brain proved difficult without visible primary and histology.
  • [MeSH-major] Brain Neoplasms / secondary. Head and Neck Neoplasms / pathology. Hemangiosarcoma / pathology. Scalp

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  • (PMID = 22736558.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anticoagulants
  • [Other-IDs] NLM/ PMC3047381
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98. Salameh F, Henig I, Bar-Shalom R, Maza I: Metastatic angiosarcoma of the scalp causing Kasabach-Merritt syndrome. Am J Med Sci; 2007 May;333(5):293-5
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  • [Title] Metastatic angiosarcoma of the scalp causing Kasabach-Merritt syndrome.
  • We report a case of thrombocytopenia caused by Kasabach-Merritt syndrome (KMS) in a 69-year-old man with a metastatic angiosarcoma of the scalp.
  • A review of the literature revealed that only 4 cases of KMS associated with angiosarcoma have been previously reported.
  • This is the first case of thrombocytopenia caused by KMS associated with small metastatic lesions of angiosarcoma that developed after the primary lesion has been completely removed.
  • [MeSH-major] Head and Neck Neoplasms. Hemangioma, Capillary / complications. Hemangiosarcoma / secondary. Scalp. Skin Neoplasms. Thrombocytopenia / complications

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  • (PMID = 17505172.001).
  • [ISSN] 0002-9629
  • [Journal-full-title] The American journal of the medical sciences
  • [ISO-abbreviation] Am. J. Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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99. Suárez Antelo J, Rodríguez García C, Montero Martínez C, Verea Hernando H: [Pulmonary Ewing sarcoma/primitive neuroectodermal tumor: a case report and a review of the literature]. Arch Bronconeumol; 2010 Jan;46(1):44-6
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  • The most common intrathoracic variants are synovial sarcoma, angiosarcoma, leiomyosarcoma, rhabdomyosarcoma, and sarcomatoid mesothelioma.
  • Radiography, ventilation-perfusion scintigraphy, and a bone marrow biopsy confirmed that the tumor was not metastatic.

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  • [Copyright] Copyright (c) 2009 SEPAR. Published by Elsevier Espana. All rights reserved.
  • (PMID = 19656607.001).
  • [ISSN] 1579-2129
  • [Journal-full-title] Archivos de bronconeumología
  • [ISO-abbreviation] Arch. Bronconeumol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 13
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100. Luk A, Nwachukwu H, Lim KD, Cusimano RJ, Butany J: Cardiac angiosarcoma: a case report and review of the literature. Cardiovasc Pathol; 2010 May-Jun;19(3):e69-74
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cardiac angiosarcoma: a case report and review of the literature.
  • We present the case of a 36-year-old woman with widespread metastatic cardiac angiosarcoma to the lungs and the liver.
  • [MeSH-major] Heart Neoplasms / pathology. Hemangiosarcoma / secondary

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 19150248.001).
  • [ISSN] 1879-1336
  • [Journal-full-title] Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology
  • [ISO-abbreviation] Cardiovasc. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 34
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