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1. Zver S, Bracko M, Andoljsek D: Primary bone angiosarcoma in a patient with Gaucher disease. Int J Hematol; 2010 Sep;92(2):374-7
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  • [Title] Primary bone angiosarcoma in a patient with Gaucher disease.
  • Skeletal pain and the resulting skeletal complications are common in Gaucher disease.
  • The paper describes the case of a patient with Gaucher disease who had advancing pain in the right knee and femur, which was first attributed to the basic disease.
  • After a pathological fracture of the painful part of the leg, it became evident that the patient suffered from primary bone angiosarcoma.
  • From this case, we learnt that not every skeletal pain in Gaucher disease represents a skeletal manifestation of this disease.
  • [MeSH-major] Bone Neoplasms / diagnosis. Gaucher Disease / complications. Hemangiosarcoma / diagnosis


2. Wiley JL, Rook KA, Clifford CA, Gregor TP, Sorenmo KU: Efficacy of doxorubicin-based chemotherapy for non-resectable canine subcutaneous haemangiosarcoma. Vet Comp Oncol; 2010 Sep;8(3):221-33
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  • [Title] Efficacy of doxorubicin-based chemotherapy for non-resectable canine subcutaneous haemangiosarcoma.
  • Eighteen dogs with measurable subcutaneous haemangiosarcoma (SQHSA) were treated with doxorubicin-based chemotherapy.
  • [MeSH-major] Antibiotics, Antineoplastic / therapeutic use. Dog Diseases / drug therapy. Doxorubicin / therapeutic use. Hemangiosarcoma / veterinary. Soft Tissue Neoplasms / veterinary

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  • (PMID = 20691029.001).
  • [ISSN] 1476-5829
  • [Journal-full-title] Veterinary and comparative oncology
  • [ISO-abbreviation] Vet Comp Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 80168379AG / Doxorubicin
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3. Contreras AL, Malpica A: Angiosarcoma arising in mature cystic teratoma of the ovary: a case report and review of the literature. Int J Gynecol Pathol; 2009 Sep;28(5):453-7
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  • [Title] Angiosarcoma arising in mature cystic teratoma of the ovary: a case report and review of the literature.
  • Malignant transformation of this neoplasm is rare and is mostly represented by squamous carcinoma.
  • Less frequently, malignant transformation is represented by a sarcoma.
  • To date, only 5 cases of angiosarcoma arising in a mature cystic teratoma of the ovary have been reported.
  • [MeSH-major] Hemangiosarcoma / pathology. Neoplasms, Multiple Primary / pathology. Ovarian Neoplasms / pathology. Teratoma / pathology

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  • (PMID = 19696615.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 80168379AG / Doxorubicin; UM20QQM95Y / Ifosfamide
  • [Number-of-references] 23
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4. Lee HM, Song SY, Park JO, Kim BH: Primary immature teratoma of the prostate with angiosarcoma component: its unusual response to chemotherapy. Int J Urol; 2006 Mar;13(3):305-7
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  • [Title] Primary immature teratoma of the prostate with angiosarcoma component: its unusual response to chemotherapy.
  • Here, we present a case of immature teratoma of prostatic origin, which included an angiosarcoma component.
  • Angiosarcoma, although quite rare, should be included in the differential diagnosis as a component of prostatic teratoma, especially in cases in which the tumor proves unresponsive to well-known chemotherapeutic protocols.
  • This is, to our knowledge, the first reported case of primary prostatic immature teratoma containing an angiosarcoma component.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Hemangiosarcoma / drug therapy. Neoplasms, Multiple Primary. Prostatic Neoplasms / drug therapy. Teratoma / drug therapy
  • [MeSH-minor] Adult. Antineoplastic Agents / administration & dosage. Biopsy, Needle. Bleomycin / administration & dosage. Bleomycin / therapeutic use. Cisplatin / administration & dosage. Cisplatin / therapeutic use. Diagnosis, Differential. Etoposide / administration & dosage. Etoposide / therapeutic use. Humans. Male. Tomography, X-Ray Computed

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  • (PMID = 16643634.001).
  • [ISSN] 0919-8172
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 11056-06-7 / Bleomycin; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin; BEP protocol
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5. Saitoh J, Sakurai H, Suzuki Y, Katoh H, Takahashi T, Nakano T: Metastatic angiosarcoma of the lung with alveolar hemorrhage. Jpn J Radiol; 2009 Nov;27(9):381-4
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  • [Title] Metastatic angiosarcoma of the lung with alveolar hemorrhage.
  • A case of metastatic angiosarcoma of the lung with alveolar hemorrhage was experienced.
  • By immunohistochemical staining, CD31, CD34 and Factor VIII were found to be positive, and the tumor was diagnosed as epithelioid angiosarcoma.
  • [MeSH-major] Hemangiosarcoma / complications. Hemangiosarcoma / secondary. Hemorrhage / etiology. Lung Neoplasms / complications. Lung Neoplasms / secondary. Uterine Cervical Neoplasms / pathology


6. Marolf A, Specht A, Thompson M, Castleman W: Imaging diagnosis: penile hemangiosarcoma. Vet Radiol Ultrasound; 2006 Sep-Oct;47(5):474-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Imaging diagnosis: penile hemangiosarcoma.
  • [MeSH-major] Dog Diseases / radiography. Hemangiosarcoma / veterinary. Penile Neoplasms / veterinary
  • [MeSH-minor] Animals. Diagnosis, Differential. Dogs. Male. Radiography, Abdominal / veterinary

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  • (PMID = 17009511.001).
  • [ISSN] 1058-8183
  • [Journal-full-title] Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association
  • [ISO-abbreviation] Vet Radiol Ultrasound
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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7. Verge J, Albiol J, Navas M, Martín C: [Primary angiosarcoma of the spleen with liver metastases. Case report and literature review]. Cir Esp; 2005 Jul;78(1):50-2
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  • [Title] [Primary angiosarcoma of the spleen with liver metastases. Case report and literature review].
  • [Transliterated title] Angiosarcoma primario de bazo con metástasis hepáticas: presentación de un caso y revisión de la bibliografía.
  • Angiosarcomas of the spleen are infrequent tumors that often present with liver metastases.
  • Immunohistochemical markers can aid preoperative diagnosis since radiological and ultrasonographic images are fairly nonspecific.
  • [MeSH-major] Hemangiosarcoma / secondary. Hemangiosarcoma / surgery. Liver Neoplasms / secondary. Liver Neoplasms / surgery. Splenic Neoplasms / pathology. Splenic Neoplasms / surgery

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  • (PMID = 16420791.001).
  • [ISSN] 0009-739X
  • [Journal-full-title] Cirugía española
  • [ISO-abbreviation] Cir Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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8. Bien E, Stachowicz-Stencel T, Balcerska A, Godzinski J, Kazanowska B, Perek-Polnik M, Madziara W, Rybczynska A, Kurylak A, Zalewska-Szewczyk B, Peregud-Pogorzelski J: Angiosarcoma in children - still uncontrollable oncological problem. The report of the Polish Paediatric Rare Tumours Study. Eur J Cancer Care (Engl); 2009 Jul;18(4):411-20
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  • [Title] Angiosarcoma in children - still uncontrollable oncological problem. The report of the Polish Paediatric Rare Tumours Study.
  • Angiosarcoma in children - still uncontrollable oncological problem.
  • The report of the Polish Paediatric Rare Tumours StudyAngiosarcoma is a rare, highly malignant vascular neoplasm with little data available on its clinical course and management in children.
  • Ten children with angiosarcoma (M/F: 6/4; aged 2, 3-16 years) registered in Polish Paediatric Rare Tumours and Soft Tissue Sarcomas Studies between 1992 and 2006.
  • Nine patients died of disease (overall survival 6-66 months), and one child after mutilating secondary resection is alive.
  • Angiosarcoma in children is highly aggressive with an extremely poor prognosis.
  • [MeSH-major] Hemangiosarcoma / pathology. Hemangiosarcoma / therapy. Sarcoma / pathology. Sarcoma / therapy
  • [MeSH-minor] Adolescent. Antineoplastic Agents / therapeutic use. Child. Child, Preschool. Disease Progression. Humans. Male. Poland / epidemiology. Prognosis. Radiotherapy. Recurrence. Retrospective Studies. Survival Rate

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  • (PMID = 19490008.001).
  • [ISSN] 1365-2354
  • [Journal-full-title] European journal of cancer care
  • [ISO-abbreviation] Eur J Cancer Care (Engl)
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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9. Chow TL, Chan TT, Chow TK, Fung SC, Lam SH: Reconstruction with submental flap for aggressive orofacial cancer. Plast Reconstr Surg; 2007 Aug;120(2):431-6
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  • METHODS: From March of 2003 to September of 2005, 10 patients (nine with intraoral squamous cell carcinoma and one with facial angiosarcoma) underwent submental flap reconstruction after surgical extirpation of aggressive orofacial malignancies.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Head and Neck Neoplasms / surgery. Hemangiosarcoma / surgery. Reconstructive Surgical Procedures / methods. Surgical Flaps

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  • (PMID = 17632345.001).
  • [ISSN] 1529-4242
  • [Journal-full-title] Plastic and reconstructive surgery
  • [ISO-abbreviation] Plast. Reconstr. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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10. Kim Y, Reinecke S, Malarkey DE: Cutaneous angiomatosis in a young dog. Vet Pathol; 2005 May;42(3):378-81
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  • The lesion on the antebrachium had been noticed since the dog was adopted at 6 months of age and appeared to have increased in size over an 11-week period, at which time skin punch biopsy revealed an infiltrative pattern of well-differentiated blood vessels leading to an interpretation that the lesion was a well-differentiated hemangiosarcoma.
  • [MeSH-minor] Animals. Diagnosis, Differential. Dogs. Female. Forelimb / pathology. Histological Techniques / veterinary. Immunohistochemistry / veterinary

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  • (PMID = 15872389.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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11. Vertse G, Svastics E, Iványi A: [Postirradiation angiosarcoma of the breast]. Magy Seb; 2010 Aug;63(4):164-7
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  • [Title] [Postirradiation angiosarcoma of the breast].
  • [Transliterated title] Besugárzás utáni angiosarcoma emloben.
  • Although secondary angiosarcomas (AS) are relatively rare neoplasms, they are increasingly recognized as the result of more breast conserving therapy (BCT) followed by radiotherapy.
  • The diagnosis of this very aggressive and rapidly spreading tumour is based on the immunohystochemical characteristics of the biopsy specimen.
  • [MeSH-major] Breast Neoplasms / radiotherapy. Hemangiosarcoma / diagnosis. Hemangiosarcoma / etiology. Mastectomy, Segmental. Neoplasms, Second Primary / diagnosis. Neoplasms, Second Primary / etiology

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  • (PMID = 20724241.001).
  • [ISSN] 0025-0295
  • [Journal-full-title] Magyar sebészet
  • [ISO-abbreviation] Magy Seb
  • [Language] hun
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Hungary
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers, Tumor
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12. Yilmazlar T, Kirdak T, Adim S, Ozturk E, Yerci O: A case of hemangiosarcoma in thyroid with severe anemia due to bone marrow metastasis. Endocr J; 2005 Feb;52(1):57-9
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  • [Title] A case of hemangiosarcoma in thyroid with severe anemia due to bone marrow metastasis.
  • Postoperative histopathological examination of the specimen revealed hemangiosarcoma of the thyroid.
  • After establishment of the diagnosis chemotherapy was started.
  • Thyroid hemangiosarcoma can metastasize to the bone marrow and anemia may be an indicator of the advanced disease.
  • In the differential diagnosis of the anemia, bone marrow metastasis and bone marrow biopsy should be considered in suspected cases.
  • [MeSH-major] Anemia / etiology. Bone Marrow Neoplasms / complications. Bone Marrow Neoplasms / secondary. Hemangiosarcoma / secondary. Thyroid Neoplasms / pathology

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  • (PMID = 15758558.001).
  • [ISSN] 0918-8959
  • [Journal-full-title] Endocrine journal
  • [ISO-abbreviation] Endocr. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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13. Liu H, Zang C, Emde A, Planas-Silva MD, Rosche M, Kühnl A, Schulz CO, Elstner E, Possinger K, Eucker J: Anti-tumor effect of honokiol alone and in combination with other anti-cancer agents in breast cancer. Eur J Pharmacol; 2008 Sep 4;591(1-3):43-51
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  • Honokiol, an active component isolated and purified from Chinese traditional herb magnolia, was demonstrated to inhibit growth and induce apoptosis of different cancer cell lines such as human leukaemia, colon, and lung cancer cell lines; to attenuate the angiogenic activities of human endothelial cells in vitro; and to efficiently suppress the growth of angiosarcoma in nude mice.


14. Khalil MF, Thomas A, Aassad A, Rubin M, Taub RN: Epithelioid Angiosarcoma of the Small Intestine After Occupational Exposure to Radiation and Polyvinyl Chloride: A case Report and Review of Literature. Sarcoma; 2005;9(3-4):161-4
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  • [Title] Epithelioid Angiosarcoma of the Small Intestine After Occupational Exposure to Radiation and Polyvinyl Chloride: A case Report and Review of Literature.
  • Angiosarcomas represent 1-2% of soft tissue sarcomas and most frequently occur in the subcutis.
  • The association between angiosarcomas and certain toxic chemical substances or previous external-beam radiation therapy is well documented.

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  • (PMID = 18521426.001).
  • [ISSN] 1357-714X
  • [Journal-full-title] Sarcoma
  • [ISO-abbreviation] Sarcoma
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC2395632
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15. El-Osta HE, Yammine YS, Chehab BM, Fields AS, Moore DF Jr, Mattar BI: Unexplained hemopericardium as a presenting feature of primary cardiac angiosarcoma: a case report and a review of the diagnostic dilemma. J Thorac Oncol; 2008 Jul;3(7):800-2
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  • [Title] Unexplained hemopericardium as a presenting feature of primary cardiac angiosarcoma: a case report and a review of the diagnostic dilemma.
  • This report describes a patient diagnosed with a cardiac angiosarcoma.
  • His pericardial effusion recurred 3 weeks later, at which time he was found to have a large right atrial mass which proved to be a cardiac angiosarcoma.
  • This case report underscores the difficulties encountered in the diagnosis of cardiac angiosarcoma.
  • [MeSH-major] Heart Neoplasms / complications. Hemangiosarcoma / complications. Pericardial Effusion / etiology

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  • (PMID = 18594329.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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16. Shehan JM, Ahmed I: Angiosarcoma arising in a lymphedematous abdominal pannus with histologic features reminiscent of Kaposi's sarcoma: report of a case and review of the literature. Int J Dermatol; 2006 May;45(5):499-503
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  • [Title] Angiosarcoma arising in a lymphedematous abdominal pannus with histologic features reminiscent of Kaposi's sarcoma: report of a case and review of the literature.
  • BACKGROUND: Despite common endothelial origins, angiosarcoma and Kaposi's sarcoma are clinically and histologically distinct vascular proliferations.
  • The development of angiosarcoma in a chronically edematous abdominal pannus is extremely uncommon.
  • Similarly, tumors with the combined histologic features of angiosarcoma and Kaposi's sarcoma have rarely been described.
  • METHODS: We reviewed the literature on angiosarcoma arising in a lymphedematous abdominal pannus and evaluated an 81-year-old morbidly obese woman who had profound, long-standing edema of the lower abdominal wall in which an aggressive vascular tumor developed.
  • All patients were women who generally experienced rapid disease progression.
  • In addition, in our patient, sequential cutaneous sampling from different lesional sites demonstrated disparate histologic changes, ranging from those of classic Kaposi's sarcoma to high-grade angiosarcoma, to areas with combined features of the two tumors.
  • CONCLUSION: It is important to note that angiosarcoma may develop in the abdomen in association with chronic lymphedema, as demonstrated by the cases noted in this report.
  • In addition, our case highlights the difficulty in differentiating histologically angiosarcoma from Kaposi's sarcoma in some situations, and demonstrates the value of close clinicopathologic correlation and sequential tissue sampling in evaluating problematic cases.
  • [MeSH-major] Edema. Hemangiosarcoma / diagnosis. Obesity, Morbid. Skin Neoplasms / diagnosis
  • [MeSH-minor] Abdomen / pathology. Aged. Aged, 80 and over. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Diagnosis, Differential. Fatal Outcome. Female. Humans. Lung Neoplasms / diagnosis. Lung Neoplasms / drug therapy. Lung Neoplasms / secondary. Sarcoma, Kaposi / diagnosis

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  • [CommentIn] Int J Dermatol. 2007 Jun;46(6):662 [17550576.001]
  • (PMID = 16700780.001).
  • [ISSN] 0011-9059
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 21
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17. Bhalla R, Nassar A: Cardiac angiosarcoma: report of a case diagnosed by echocardiographic-guided fine-needle aspiration. Diagn Cytopathol; 2007 Mar;35(3):164-6
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  • [Title] Cardiac angiosarcoma: report of a case diagnosed by echocardiographic-guided fine-needle aspiration.
  • The authors present a case of cardiac angiosarcoma diagnosed by fine-needle aspiration (FNA) in a 33-year-old male.
  • A diagnosis of cardiac angiosarcoma was made, following which, the patient underwent treatment with chemotherapy.
  • [MeSH-major] Echocardiography. Heart Neoplasms / pathology. Heart Neoplasms / ultrasonography. Hemangiosarcoma / pathology. Hemangiosarcoma / ultrasonography

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  • (PMID = 17415920.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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18. Hamidi M, Moody JS, Weigel TL, Kozak KR: Primary cardiac sarcoma. Ann Thorac Surg; 2010 Jul;90(1):176-81
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  • [Title] Primary cardiac sarcoma.
  • BACKGROUND: The presentation, management, and outcome of patients with primary cardiac sarcomas are not well defined.
  • Furthermore, the role of adjuvant therapy has not been delineated in the management of primary cardiac sarcomas.
  • METHODS: Patients with primary cardiac sarcoma and noncardiac sarcoma, diagnosed between 1988 and 2005, were identified in the Surveillance, Epidemiology, and End Results (SEER) database.
  • Clinical characteristics and outcomes of primary cardiac sarcoma were defined and compared with the characteristics of noncardiac sarcomas.
  • Univariate and multivariate methods were used to identify factors associated with primary cardiac sarcoma survival.
  • RESULTS: Compared with noncardiac sarcomas, primary cardiac sarcomas were found to occur in a younger age group and were more likely to present with advanced disease.
  • Primary cardiac sarcomas were ten times more likely to be vessel-derived (eg, angiosarcoma), comprising almost half of all cases.
  • Median overall survival for cardiac sarcoma patients was 6 months whereas that for noncardiac sarcoma patients was significantly longer at 93 months (p < 0.001).
  • Furthermore, cardiac sarcoma patients who underwent surgery had a median survival of 12 months whereas those who did not undergo surgery had a median survival of 1 month (p < 0.001).
  • CONCLUSIONS: Cardiac sarcomas are a distinct, rare subset of soft tissue sarcomas with a poor prognosis.
  • [MeSH-major] Heart Neoplasms / epidemiology. Sarcoma / epidemiology

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  • [Copyright] Copyright 2010 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.
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  • (PMID = 20609770.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / T32 CA009614; United States / NCI NIH HHS / CA / T32 CA009614-20
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Other-IDs] NLM/ NIHMS297876; NLM/ PMC4201046
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19. Mobini N: Cutaneous epithelioid angiosarcoma: a neoplasm with potential pitfalls in diagnosis. J Cutan Pathol; 2009 Mar;36(3):362-9
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  • [Title] Cutaneous epithelioid angiosarcoma: a neoplasm with potential pitfalls in diagnosis.
  • Angiosarcoma (AS) is a rare neoplasm.
  • The epithelioid variant of the disease, however, is a rare entity.
  • This subset can histologically mimic non-vascular neoplasms and impose serious challenges in reaching the correct diagnosis.
  • We present five patients with cutaneous epithelioid angiosarcoma (EAS); in none, the clinical diagnosis included a vascular lesion.
  • The histopathological examination of the biopsy specimens by hematoxylin and eosin method was not suggestive of a malignant vascular neoplasm initially and the differential diagnoses included carcinoma, malignant melanoma and atypical lymphoid infiltrate.
  • Only after performing immunohistochemical studies that included vascular markers, a definitive diagnosis was possible.
  • Cutaneous EAS is a rare variant of cutaneous AS that can mimic a variety of more common, non-vascular neoplasms, creating a major pitfall in the diagnosis.
  • A careful and thorough histopathological examination and a high index of suspicion, along with appropriate immunohistochemical evaluation, can help reach a correct diagnosis and provide optimal patient care.
  • [MeSH-major] Hemangiosarcoma / pathology. Melanoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. Female. Humans. Male. Middle Aged

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  • (PMID = 19220634.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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20. Rozen WM, Mann GB: Angiosarcoma arising in an unirradiated breast with subsequent pituitary metastasis. Clin Breast Cancer; 2007 Oct;7(10):811-3
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  • [Title] Angiosarcoma arising in an unirradiated breast with subsequent pituitary metastasis.
  • Angiosarcoma of the breast is a rare condition with known risk factors.
  • The Stewart-Treves syndrome describes angiosarcoma of the arm or breast in the setting of adjuvant radiation therapy (RT) after breast conservation surgery.
  • Angiosarcoma of the breast, in the absence of RT, is rarer still.
  • We present a unique case of angiosarcoma of the breast, diagnosed 6 years after conservative surgery for carcinoma of the breast when no adjuvant RT was given.
  • Chronic postoperative lymphoedema in the breast delayed the investigation of skin changes, with an eventual diagnosis of angiosarcoma.
  • An isolated pituitary metastasis 9 months from the diagnosis, the first such reported case, adds to the complexity of the case.
  • The diagnosis and management of angiosarcoma of the breast is discussed.
  • Angiosarcoma is a rare occurrence after breast conservative surgery.
  • Postoperative lymphoedema can impede early diagnosis.
  • The disease can display unique metastatic potential.
  • [MeSH-major] Breast Neoplasms / pathology. Hemangiosarcoma / secondary. Neoplasms, Second Primary / pathology. Pituitary Neoplasms / secondary

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  • (PMID = 18021485.001).
  • [ISSN] 1526-8209
  • [Journal-full-title] Clinical breast cancer
  • [ISO-abbreviation] Clin. Breast Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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21. Konishi Y, Sato H, Fujimoto T, Tanaka H, Takahashi O, Tanaka T: A case of primary uterine angiosarcoma: magnetic resonance imaging and computed tomography findings. Int J Gynecol Cancer; 2007 Jan-Feb;17(1):280-4
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  • [Title] A case of primary uterine angiosarcoma: magnetic resonance imaging and computed tomography findings.
  • Primary uterine angiosarcoma is exceedingly rare and has a poor prognosis.
  • Moreover, the radiologic findings of this disease have not been previously documented.
  • We present a case of a 62-year-old woman with primary uterine angiosarcoma who underwent abdominal hysterectomy and bilateral salpingo-oophorectomy.
  • Histologically, interlacing vascular spaces were lined by endothelial cells showing nuclear pleomorphism and mitotic activity.
  • Immunohistochemical staining was positive for the endothelial cell markers CD31, CD34, and Factor VIII, supporting the diagnosis of primary uterine angiosarcoma.
  • Radiologically, the most helpful sign in the characterization of uterine angiosarcoma is marked heterogeneity on T2-weighted MRI with focal areas of high signal intensity, known as the "cauliflower-like appearance."
  • In addition, findings of a strongly enhanced lesion on gadolinium-enhanced T1-weighted MRI and contrast-enhanced CT also support the diagnosis of angiosarcoma.
  • [MeSH-major] Hemangiosarcoma / diagnosis. Uterine Neoplasms / diagnosis

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  • (PMID = 17291268.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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22. Rudisaile SN, Hurt MA, Santa Cruz DJ: Granular cell atypical fibroxanthoma. J Cutan Pathol; 2005 Apr;32(4):314-7
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  • The differential diagnosis of granular cells in neoplasms containing cytological pleomorphism is challenging in view of the many different neoplasms that may present with granular cytoplasm.
  • These include the conventional granular cell tumor and its malignant form, leiomyoma, leiomyosarcoma, dermatofibroma, dermatofibrosarcoma protuberans, and angiosarcoma.

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  • (PMID = 15769283.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 25
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23. Asmane I, Litique V, Heymann S, Marcellin L, Métivier AC, Duclos B, Bergerat JP, Kurtz JE: Adriamycin, cisplatin, ifosfamide and paclitaxel combination as front-line chemotherapy for locally advanced and metastatic angiosarcoma. Analysis of three case reports and review of the literature. Anticancer Res; 2008 Sep-Oct;28(5B):3041-5
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  • [Title] Adriamycin, cisplatin, ifosfamide and paclitaxel combination as front-line chemotherapy for locally advanced and metastatic angiosarcoma. Analysis of three case reports and review of the literature.
  • Angiosarcoma represents 1 to 2% of soft tissue tumors.
  • It originates from endothelial cells of small blood vessels and may affect a variety of organs, including the retroperitoneum, skeletal muscle, subcutis, liver, heart and breast.
  • The outcome of angiosarcoma is poor for those patients in whom aggressive surgery cannot be considered.
  • We report three cases of angiosarcoma in which first-line chemotherapy with adriamycin 40 mg/m2 day 1, ifosfamide 3 g/m2 day 1-2, cisplatin 35 mg/m2 day 1-2 and paclitaxel 175 mg/m2 day 3 led to clinically meaningful responses.
  • We emphasize the need for designing trials specifically dedicated to angiosarcomas, as this rare and severe condition may be a target for new antiangiogenic drugs.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bone Neoplasms / drug therapy. Breast Neoplasms / drug therapy. Hemangiosarcoma / drug therapy. Soft Tissue Neoplasms / drug therapy

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  • (PMID = 19031953.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 80168379AG / Doxorubicin; P88XT4IS4D / Paclitaxel; Q20Q21Q62J / Cisplatin; UM20QQM95Y / Ifosfamide
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24. Mendiz O, Lev G, Valdivieso L, Fava C, Gallucci E, Baldessari E, Favaloro R: Lifesaving kissing stent for pulmonary trunk stenosis due to primary angiosarcoma. Ann Vasc Surg; 2010 Nov;24(8):1135.e9-12
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  • [Title] Lifesaving kissing stent for pulmonary trunk stenosis due to primary angiosarcoma.
  • [MeSH-major] Arterial Occlusive Diseases / therapy. Endovascular Procedures / instrumentation. Hemangiosarcoma / complications. Pulmonary Artery. Stents. Vascular Neoplasms / complications

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  • [Copyright] Copyright © 2010 Annals of Vascular Surgery Inc. Published by Elsevier Inc. All rights reserved.
  • (PMID = 21035708.001).
  • [ISSN] 1615-5947
  • [Journal-full-title] Annals of vascular surgery
  • [ISO-abbreviation] Ann Vasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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25. Manner J, Radlwimmer B, Hohenberger P, Mössinger K, Küffer S, Sauer C, Belharazem D, Zettl A, Coindre JM, Hallermann C, Hartmann JT, Katenkamp D, Katenkamp K, Schöffski P, Sciot R, Wozniak A, Lichter P, Marx A, Ströbel P: MYC high level gene amplification is a distinctive feature of angiosarcomas after irradiation or chronic lymphedema. Am J Pathol; 2010 Jan;176(1):34-9
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  • [Title] MYC high level gene amplification is a distinctive feature of angiosarcomas after irradiation or chronic lymphedema.
  • Angiosarcomas (AS) are rare vascular malignancies that arise either de novo as primary tumors or secondary to irradiation or chronic lymphedema.
  • The cytogenetics of angiosarcomas are poorly characterized.
  • Fluorescence in situ hybridization analysis in 28 primary and 33 secondary angiosarcomas (31 tumors secondary to irradiation, 2 tumors secondary to chronic lymphedema) confirmed high level amplification of MYC on chromosome 8q24.21 as a recurrent genetic alteration found exclusively in 55% of AS secondary to irradiation or chronic lymphedema, but not in primary AS.
  • This finding may have implications both for the diagnosis and treatment of these tumors.
  • [MeSH-major] Gene Amplification / genetics. Hemangiosarcoma / etiology. Hemangiosarcoma / genetics. Lymphedema / complications. Proto-Oncogene Proteins c-myc / genetics. Radiotherapy / adverse effects
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Chromosome Deletion. Chronic Disease. DNA Copy Number Variations / genetics. Female. Genetic Loci / genetics. Homozygote. Humans. In Situ Hybridization, Fluorescence. Male. Middle Aged

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  • (PMID = 20008140.001).
  • [ISSN] 1525-2191
  • [Journal-full-title] The American journal of pathology
  • [ISO-abbreviation] Am. J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Proto-Oncogene Proteins c-myc
  • [Other-IDs] NLM/ PMC2797867
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26. Kajo K, Macháleková K, Pauer M: [Retiform hemangioendotelioma in a 8-year-old girl--case report]. Cesk Patol; 2009 Jul;45(3):72-4
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  • [Title] [Retiform hemangioendotelioma in a 8-year-old girl--case report].
  • Retiform hemangioendothelioma (RHE) is a rare vascular tumoriform lesion characterized by rete testis--like vascular structures.
  • RHE belongs to a group of vascular tumors of intermediate malignancy and together with Dabska tumor form a category of so-called hobnail hemangioendotheliomas.
  • Histologically, the tumor consisted of a net of vessel formations with retiform appearance and prominent endothelial nuclei.
  • Other benign and malignant vascular lesions with hobnail cells (hemangioma, angiosarcoma) have to be considered in differential diagnosis.
  • [MeSH-major] Hemangioendothelioma / pathology. Vascular Neoplasms / pathology

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  • (PMID = 19764161.001).
  • [ISSN] 1210-7875
  • [Journal-full-title] Československá patologie
  • [ISO-abbreviation] Cesk Patol
  • [Language] slo
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Czech Republic
  • [Chemical-registry-number] 0 / Lewis Blood-Group System
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27. Bai XF, Liang JW, Zhao DB, Shao YF, Zhao P: [Clinicopathologic features and treatment of primary splenic tumors]. Zhonghua Yi Xue Za Zhi; 2007 Jun 26;87(24):1673-5
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  • Of the 24 malignant cases, 16 suffered from splenic lymphoma and 8 from angiosarcoma.
  • The mean surviving time of angiosarcoma was only 10.4 months.

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  • (PMID = 17825145.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD20; 0 / Antigens, CD79
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28. Simpson L, Kumar SK, Okuno SH, Schaff HV, Porrata LF, Buckner JC, Moynihan TJ: Malignant primary cardiac tumors: review of a single institution experience. Cancer; 2008 Jun;112(11):2440-6
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  • [Title] Malignant primary cardiac tumors: review of a single institution experience.
  • BACKGROUND: Primary cardiac sarcomas are uncommon.
  • The authors undertook to review the Mayo Clinic's experience with primary cardiac sarcomas consisting of 34 patients seen over a 32-year period.
  • METHODS: The patient database at the Mayo Clinic was searched to identify patients with malignant tumors of the heart seen during the 32-year period between 1975 and 2007.
  • Thirty-four patients with primary cardiac sarcomas were identified and their medical records reviewed for details pertaining to presenting symptoms, staging modalities, treatment approaches, and outcomes.
  • The mean duration of symptoms at the time of diagnosis was 3.6 months.
  • The most common histologic type was angiosarcoma (41%).
  • Patients with angiosarcoma had a lower survival compared with patients with other histologies (5 months vs 17 months; P = .01).
  • The median survival of patients with metastatic disease was 5 months versus 15 months in patients without metastatic disease (P = .03 by the log-rank test).
  • CONCLUSIONS: Cardiac sarcomas remain a rare but lethal disease.
  • Compared with extracardiac sarcomas, the prognosis for patients with cardiac sarcomas remains very poor.
  • [MeSH-major] Heart Neoplasms / pathology. Sarcoma / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Disease-Free Survival. Female. Humans. Male. Middle Aged. Neoplasm Staging. Prognosis. Survival Rate. Treatment Outcome

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  • [Copyright] (c) 2008 American Cancer Society.
  • (PMID = 18428209.001).
  • [ISSN] 1097-0142
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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29. Santos P, Pinto GM, Pereira A, Cruz T, Afonso A, Cardoso J: Sequential treatment of angiosarcoma of the back with liposomal doxorubicin and radiotherapy. J Eur Acad Dermatol Venereol; 2005 Nov;19(6):779-80
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  • [Title] Sequential treatment of angiosarcoma of the back with liposomal doxorubicin and radiotherapy.
  • [MeSH-major] Antibiotics, Antineoplastic / therapeutic use. Back. Doxorubicin / therapeutic use. Hemangiosarcoma / drug therapy. Hemangiosarcoma / radiotherapy. Skin Neoplasms / drug therapy. Skin Neoplasms / radiotherapy

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  • (PMID = 16268901.001).
  • [ISSN] 0926-9959
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Liposomes; 80168379AG / Doxorubicin
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31. Walker DM, Malarkey DE, Seilkop SK, Ruecker FA, Funk KA, Wolfe MJ, Treanor CP, Foley JF, Hahn FF, Hardisty JF, Walker VE: Transplacental carcinogenicity of 3'-azido-3'-deoxythymidine in B6C3F1 mice and F344 rats. Environ Mol Mutagen; 2007 Apr-May;48(3-4):283-98
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  • Under the conditions of these two-year studies, there was clear evidence of carcinogenic activity based upon significant dose-related trends and increases in the incidences of hemangiosarcoma in male mice and mononuclear cell leukemia in female rats.

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  • [Copyright] (c) 2006 Wiley-Liss, Inc.
  • (PMID = 17358026.001).
  • [ISSN] 0893-6692
  • [Journal-full-title] Environmental and molecular mutagenesis
  • [ISO-abbreviation] Environ. Mol. Mutagen.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01CA95741; United States / NICHD NIH HHS / HD / R01HD33648
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-HIV Agents; 0 / Carcinogens; 0 / Reverse Transcriptase Inhibitors; 0 / Tumor Suppressor Protein p53; 4B9XT59T7S / Zidovudine
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32. Carda C, Ferrer J, Vilanova M, Peydró A, Llombart-Bosch A: Anaplastic carcinoma of the thyroid with rhabdomyosarcomatous differentiation: a report of two cases. Virchows Arch; 2005 Jan;446(1):46-51
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  • Anaplastic carcinoma of the thyroid gland (ACT) is a highly malignant tumor that is almost invariably associated with a fatal outcome.
  • The spindle cell variant of ACT is usually indistinguishable from a true sarcoma and it can simulate fibrosarcoma, malignant fibrous histiocytoma (MFH), hemangiopericytoma and angiosarcoma or rhabdomyosarcoma.

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  • (PMID = 15517365.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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33. Lee BA, Wanat KA, Eisen AZ: Cutaneous angiosarcoma of the knee: a case report and review of the literature. Cutis; 2009 Feb;83(2):91-4
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  • [Title] Cutaneous angiosarcoma of the knee: a case report and review of the literature.
  • Cutaneous angiosarcoma is a rare, malignant, vascular tumor that usually occurs in the scalp and face region of elderly white men.
  • We report an unusual case of angiosarcoma occurring on the knee of a 70-year-old white woman with a strong family history of malignant melanoma in the absence of any known predisposing features.
  • [MeSH-major] Hemangiosarcoma / diagnosis. Knee Joint / pathology. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans

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  • (PMID = 19326694.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 19
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34. Arlett CF, Plowman PN, Rogers PB, Parris CN, Abbaszadeh F, Green MH, McMillan TJ, Bush C, Foray N, Lehmann AR: Clinical and cellular ionizing radiation sensitivity in a patient with xeroderma pigmentosum. Br J Radiol; 2006 Jun;79(942):510-7
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  • The patient was unusual in presenting with an angiosarcoma of the scalp, treated by surgical excision and radiotherapy.
  • [MeSH-major] Head and Neck Neoplasms / radiotherapy. Hemangiosarcoma / radiotherapy. Radiation Tolerance / genetics. Scalp. Skin Neoplasms / radiotherapy. Xeroderma Pigmentosum / complications

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  • (PMID = 16714754.001).
  • [ISSN] 0007-1285
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 156533-34-5 / XPC protein, human
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35. Maki RG, D'Adamo DR, Keohan ML, Saulle M, Schuetze SM, Undevia SD, Livingston MB, Cooney MM, Hensley ML, Mita MM, Takimoto CH, Kraft AS, Elias AD, Brockstein B, Blachère NE, Edgar MA, Schwartz LH, Qin LX, Antonescu CR, Schwartz GK: Phase II study of sorafenib in patients with metastatic or recurrent sarcomas. J Clin Oncol; 2009 Jul 01;27(19):3133-40
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  • [Title] Phase II study of sorafenib in patients with metastatic or recurrent sarcomas.
  • PURPOSE Since activity of sorafenib was observed in sarcoma patients in a phase I study, we performed a multicenter phase II study of daily oral sorafenib in patients with recurrent or metastatic sarcoma.
  • PATIENTS AND METHODS We employed a multiarm study design, each representing a sarcoma subtype with its own Simon optimal two-stage design.
  • In each arm, 12 patients who received 0 to 1 prior lines of therapy were treated (0 to 3 for angiosarcoma and malignant peripheral-nerve sheath tumor).
  • If at least one Response Evaluation Criteria in Solid Tumors (RECIST) was observed, 25 further patients with that sarcoma subtype were accrued.
  • Five of 37 patients with angiosarcoma had a partial response (response rate, 14%).
  • There was no correlation between phosphorylated extracellular signal regulated kinase expression and response in six patients with angiosarcoma with paired pre- and post-therapy biopsies.
  • CONCLUSION As a single agent, sorafenib has activity against angiosarcoma and minimal activity against other sarcomas.
  • Further evaluation of sorafenib in these and possibly other sarcoma subtypes appears warranted, presumably in combination with cytotoxic or kinase-specific agents.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Benzenesulfonates / therapeutic use. Neoplasm Recurrence, Local / drug therapy. Pyridines / therapeutic use. Sarcoma / drug therapy
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Disease-Free Survival. Female. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Niacinamide / analogs & derivatives. Phenylurea Compounds. Young Adult

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  • (PMID = 19451436.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / N01CM62202; United States / NCI NIH HHS / CA / P01 CA047179
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzenesulfonates; 0 / Phenylurea Compounds; 0 / Pyridines; 25X51I8RD4 / Niacinamide; 9ZOQ3TZI87 / sorafenib
  • [Other-IDs] NLM/ PMC2716936
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36. Bölke E, Gripp S, Peiper M, Budach W, Schwarz A, Orth K, Reinecke P, van de Nes JA: Multifocal epithelioid hemangioendothelioma: case report of a clinical chamaeleon. Eur J Med Res; 2006 Nov 30;11(11):462-6
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  • [Title] Multifocal epithelioid hemangioendothelioma: case report of a clinical chamaeleon.
  • Epithelioid hemangioendothelioma is an extremely rare vascular bone tumor with a slow growth and poor prognosis.
  • The term was designed to describe neoplasms that had an appearance in between hemangiomas and sarcomas.
  • Various synonyms for epithelioid hemangioendothelioma are used clinically: low grade anaplastic angiosarcoma, cellular hemangioma, histiocytoid hemangioma and angioendothelioma.
  • We report the course of disease of a 47-year-old man who presented to our clinic with unspecific abdominal and back pain.
  • Tumor histology of the bone and liver biopsies confirmed the diagnosis of epithelioid hemangioendothelioma.
  • Although treatment was initiated with thalidomide, the patient developed multiple organ dysfunction syndrome (MODS) and succumbed to his disease.
  • [MeSH-major] Hemangioendothelioma, Epithelioid / pathology. Liver Neoplasms / pathology. Spinal Neoplasms / pathology. Splenic Neoplasms / pathology
  • [MeSH-minor] Angiogenesis Inhibitors / therapeutic use. Diagnosis, Differential. Fatal Outcome. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Syndrome. Thalidomide / therapeutic use. Tomography, X-Ray Computed

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  • (PMID = 17182357.001).
  • [ISSN] 0949-2321
  • [Journal-full-title] European journal of medical research
  • [ISO-abbreviation] Eur. J. Med. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 4Z8R6ORS6L / Thalidomide
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37. Klaunig JE, Kamendulis LM: Mode of action of butoxyethanol-induced mouse liver hemangiosarcomas and hepatocellular carcinomas. Toxicol Lett; 2005 Mar 28;156(1):107-15
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  • [Title] Mode of action of butoxyethanol-induced mouse liver hemangiosarcomas and hepatocellular carcinomas.
  • Chronic exposure to 2-butoxyethanol resulted in an increase in liver hemangiosarcomas and hepatic carcinomas in male mouse liver.
  • Our working hypothesis is that the mode of action of butoxyethanol-induced mouse liver hemangiosarcomas and hepatic neoplasia involves the metabolism of 2-butoxyethanol to butoxyacetic acid which results in the induction of RBC hemolysis.
  • In mouse liver, increased DNA synthesis was observed in hepatocytes at 90 days and in endothelial cells at 7 and 14 days at all doses.
  • These results suggest that the induction of DNA synthesis, possibly from oxidative stress and/or Kupffer cell activation, occurs selectively in the mouse liver, in endothelial cells and in hepatocytes following exposure to 2-butoxyethanol, and support the hypothesis proposed above.
  • [MeSH-major] Carcinoma, Hepatocellular / chemically induced. Ethylene Glycols / toxicity. Hemangiosarcoma / chemically induced. Liver / drug effects. Liver Neoplasms / chemically induced. Solvents / toxicity

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  • (PMID = 15705491.001).
  • [ISSN] 0378-4274
  • [Journal-full-title] Toxicology letters
  • [ISO-abbreviation] Toxicol. Lett.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Ethylene Glycols; 0 / Oxidants; 0 / Reactive Oxygen Species; 0 / Solvents; E1UOL152H7 / Iron; I0P9XEZ9WV / n-butoxyethanol
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38. Mücke T, Deppe H, Wolff KD, Kesting MR: Gingival angiosarcoma mimicking necrotizing gingivitis. Int J Oral Maxillofac Surg; 2010 Aug;39(8):827-30
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  • [Title] Gingival angiosarcoma mimicking necrotizing gingivitis.
  • The authors present a case of a rare highly malignant condition that initially appeared clinically and histologically to be the relatively common and benign condition necrotizing gingivitis.
  • Conditions that do not follow the expected clinical course mandate further investigation because rare malignant disease is not foremost in the mind of dentists and oral and maxillofacial surgeons.
  • [MeSH-major] Gingival Neoplasms / pathology. Gingivitis, Necrotizing Ulcerative / pathology. Hemangiosarcoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Fatal Outcome. Humans. Magnetic Resonance Imaging. Male. Necrosis

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  • [Copyright] Copyright 2010 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 20359867.001).
  • [ISSN] 1399-0020
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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39. Hartley C, Ladlow J, Smith KC: Cutaneous haemangiosarcoma of the lower eyelid in an elderly white cat. J Feline Med Surg; 2007 Feb;9(1):78-81
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  • [Title] Cutaneous haemangiosarcoma of the lower eyelid in an elderly white cat.
  • A case of cutaneous haemangiosarcoma of the left lower eyelid in a 15-year-old white domestic shorthair cat is reported.
  • Surgical biopsy had revealed a locally invasive tumour composed of numerous irregular blood-filled spaces lined by a single layer of plump endothelial cells and separated by thin fibrous septa.
  • Mitotic activity was rare and the appearance was consistent with a low-grade haemangiosarcoma.
  • Histopathology of the excised tissue confirmed the presence of a well-differentiated haemangiosarcoma.
  • [MeSH-major] Cat Diseases / diagnosis. Cat Diseases / surgery. Eyelid Neoplasms / veterinary. Hemangiosarcoma / veterinary

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  • (PMID = 16949321.001).
  • [ISSN] 1098-612X
  • [Journal-full-title] Journal of feline medicine and surgery
  • [ISO-abbreviation] J. Feline Med. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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40. Güvenç MG, Dereköylü L, Korkut N, Oz F, Oz B: Intravascular papillary endothelial hyperplasia (Masson lesion) of the hypopharynx and larynx. Ear Nose Throat J; 2008 Dec;87(12):700-1
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  • [Title] Intravascular papillary endothelial hyperplasia (Masson lesion) of the hypopharynx and larynx.
  • Clinically, this lesion can be misdiagnosed as mucocele, hemangioma, Kaposi sarcoma, angiosarcoma, pyogenic granuloma, and several other lesions.
  • In this article, we report a case of intravascular papillary endothelial hyperplasia of the hypopharynx and larynx, which caused dysphagia in an 18-year-old female patient.
  • We discuss the clinical and histopathologic features, differential diagnosis, and treatment of this uncommon entity.
  • [MeSH-major] Endothelium, Vascular / pathology. Hemangiosarcoma / pathology. Hyperplasia / pathology. Hypopharyngeal Neoplasms / pathology. Laryngeal Neoplasms / pathology
  • [MeSH-minor] Adolescent. Deglutition Disorders / diagnosis. Deglutition Disorders / etiology. Diagnosis, Differential. Endoscopy / methods. Female. Humans. Severity of Illness Index

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  • (PMID = 19105147.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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41. Santo K, Dandekar U: Primary right atrial angiosarcoma. Asian Cardiovasc Thorac Ann; 2008 Dec;16(6):490-1
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  • [Title] Primary right atrial angiosarcoma.
  • A rare case of right atrial angiosarcoma is described in a 55-year-old man who was admitted with acute chest pain.
  • Emergency surgery was performed to excise a right atrial tumor, which histology confirmed to be an angiosarcoma.
  • [MeSH-major] Heart Atria / pathology. Heart Neoplasms / diagnosis. Hemangiosarcoma / diagnosis

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  • (PMID = 18984761.001).
  • [ISSN] 1816-5370
  • [Journal-full-title] Asian cardiovascular & thoracic annals
  • [ISO-abbreviation] Asian Cardiovasc Thorac Ann
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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42. Pace V, Wieczorek G, Pace M, Weber K, Perentes E: Spontaneous metastatic angiosarcoma of the tongue in a Wistar rat: morphological and immunohistochemical characterization. Toxicol Pathol; 2010 Apr;38(3):472-5
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  • [Title] Spontaneous metastatic angiosarcoma of the tongue in a Wistar rat: morphological and immunohistochemical characterization.
  • A primary angiosarcoma was found in the tongue of a six-week-old female Wistar rat, sacrificed for humane reasons during the course of a four-week toxicology study.
  • The spindle-shaped endothelial cells showed pleomorphism, hyperchromatism, and low mitotic activity; large nuclei with one or more nucleoli were present.
  • The diagnosis of tongue angiosarcoma metastasizing to the lungs was made on the basis of microscopic and immunohistochemical findings.
  • [MeSH-major] Hemangiosarcoma / secondary. Hemangiosarcoma / veterinary. Lung Neoplasms / secondary. Lung Neoplasms / veterinary. Tongue Neoplasms / pathology. Tongue Neoplasms / veterinary

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  • (PMID = 20215585.001).
  • [ISSN] 1533-1601
  • [Journal-full-title] Toxicologic pathology
  • [ISO-abbreviation] Toxicol Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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43. Safapor F, Aghajanzade M, Kohsari MR, Hoda S, Safarpor D: Spontaneous rupture of the spleen: a case report and review of the literature. Saudi J Gastroenterol; 2007 Jul-Sep;13(3):136-7
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  • The diagnosis is often missed due to the absence of any history of trauma.
  • Primary angiosarcoma of the spleen is a very rare neoplasm with disastrous prognosis.
  • Increased awareness of this condition would enhance early diagnosis and effective treatment.

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  • (PMID = 19858631.001).
  • [ISSN] 1998-4049
  • [Journal-full-title] Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association
  • [ISO-abbreviation] Saudi J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Saudi Arabia
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44. Fonseca V, Reis G, Lourenço C, Alves C, Vasconcelos AP, Martelo F, Bravio I, Lousinha A, Timóteo AT, Pinto E, Granadeiro J, Pinto Saraiva A: [Pulmonary metastasis in a cardiac angiosarcoma - case report and discussion]. Rev Port Pneumol; 2009 Nov-Dec;15(6):1175-84
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  • [Title] [Pulmonary metastasis in a cardiac angiosarcoma - case report and discussion].
  • [Transliterated title] Metastização pulmonar na apresentação de angiossarcoma cardíaco - Caso clínico e discussão.
  • Admitted to the pulmonology unit patient underwent videothoracsopy which diagnosed cardiac angiosarcoma with pulmonary metastisation.
  • [MeSH-major] Heart Neoplasms / pathology. Hemangiosarcoma / secondary. Lung Neoplasms / secondary

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  • (PMID = 19859633.001).
  • [ISSN] 2172-6825
  • [Journal-full-title] Revista portuguesa de pneumologia
  • [ISO-abbreviation] Rev Port Pneumol
  • [Language] por
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Portugal
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45. Wobeser BK, Kidney BA, Powers BE, Withrow SJ, Mayer MN, Spinato MT, Allen AL: Diagnoses and clinical outcomes associated with surgically amputated feline digits submitted to multiple veterinary diagnostic laboratories. Vet Pathol; 2007 May;44(3):362-5
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  • Eighty-five separate submissions were reviewed for diagnosis, age, sex, limb of origin, and digits affected; and the original submitting clinics were surveyed to determine clinical outcome.
  • The Kaplan-Meier product-limit method was used to determine the disease-free interval and survival time.
  • Neoplastic disease was identified in 63 of 85 submissions, with exclusively inflammatory lesions composing the other 22 cases.
  • In 60 (95.2%) of the neoplastic cases, a malignant tumor was identified.
  • Squamous cell carcinoma was the most commonly identified malignant tumor (n = 15; 23.8%) and was associated with a median survival time of 73 days.
  • Other diagnoses included fibrosarcoma (n = 14; 22.2%); adenocarcinoma, likely metastases of a primary pulmonary neoplasm (n = 13; 20.6%); osteosarcoma (n = 5; 7.9%); mast cell tumor (n = 4; 6.3%); hemangiosarcoma (n = 5; 7.9%); malignant fibrous histiocytoma (n = 2; 3.2%); giant cell tumor of bone (n = 2; 3.2%); and hemangioma (n = 2; 3.2%).
  • Various neoplasms can occur in the digits of cats, and submission of the amputated digit for histopathologic diagnosis is essential to determine the histogenesis and predict the clinical outcome.
  • [MeSH-major] Amputation / veterinary. Cat Diseases / diagnosis. Foot Diseases / veterinary. Inflammation / veterinary. Neoplasms / veterinary


46. Kim DM, Hong JH, Kim SY, Yoo KD, Seo JY, Rhee KJ, Kim BO, Goh CW, Park KM, Kim JH, Huh JH, Kim HJ, Byun YS: Primary cardiac angiosarcoma presenting with cardiac tamponade. Korean Circ J; 2010 Feb;40(2):86-9
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  • [Title] Primary cardiac angiosarcoma presenting with cardiac tamponade.
  • Primary cardiac angiosarcoma is a very rare disease with a poor prognosis.
  • We report a case of a patient with a primary cardiac angiosarcoma who presented with cardiac tamponade; the angiosarcoma was successfully resected surgically.

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  • (PMID = 20182594.001).
  • [ISSN] 1738-5555
  • [Journal-full-title] Korean circulation journal
  • [ISO-abbreviation] Korean Circ J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2827808
  • [Keywords] NOTNLM ; Angiosarcoma / Cardiac tumor / Hemopericardium
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47. Ricchetti T, Paci M, Cavazza A, Ferrari G, Annessi V, De Franco S, Sgarbi G: A case of metastatic epithelioid angiosarcoma in the lamina propria of a sigmoid tubulovillous adenoma. Tumori; 2005 Mar-Apr;91(2):210-2
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  • [Title] A case of metastatic epithelioid angiosarcoma in the lamina propria of a sigmoid tubulovillous adenoma.
  • Epithelioid angiosarcoma is an extremely rare tumor.
  • We report a case of epithelioid angiosarcoma with multiple bilateral lung infiltration, bone metastasis, and metastasis of the lamina propria of a tubulovillous adenoma of the colon.
  • [MeSH-major] Adenoma / pathology. Basement Membrane / pathology. Epithelioid Cells / pathology. Hemangiosarcoma / pathology. Hemangiosarcoma / secretion. Sigmoid Neoplasms / pathology
  • [MeSH-minor] Humans. Male. Middle Aged. Platelet Endothelial Cell Adhesion Molecule-1 / metabolism

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  • (PMID = 15948556.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Platelet Endothelial Cell Adhesion Molecule-1
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48. Vogt T: [Angiosarcoma]. Hautarzt; 2008 Mar;59(3):237-48; quiz 249-50
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  • [Title] [Angiosarcoma].
  • [Transliterated title] Angiosarkom.
  • Angiosarcomas are rare tumors accounting for 1-2% of all soft tissue sarcomas.
  • Angiosarcoma favors superficial soft tissues and skin (60%) with a clear predilection for the head and neck region.
  • The average age of the patients presenting with cutaneous angiosarcomas is around 70 years with a peak incidence in the 8th decade.
  • Secondary angiosarcoma after tissue-conserving radiation therapy for carcinoma of the breast represents an increasing problem, both the differentiation between atypical vascular lesions and true aggressive angiosarcoma and the therapy are challenging.
  • The prognosis for angiosarcoma patients is gloomy despite all therapeutic efforts.
  • [MeSH-major] Hemangiosarcoma / diagnosis. Hemangiosarcoma / therapy. Skin Neoplasms / diagnosis. Skin Neoplasms / therapy

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  • (PMID = 18273583.001).
  • [ISSN] 1432-1173
  • [Journal-full-title] Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
  • [ISO-abbreviation] Hautarzt
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 27
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49. Marsch WC: [The lymphatic system and the skin. Classification, clinical aspects und histology]. Hautarzt; 2005 Mar;56(3):277-93; quiz 294-5
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  • Malignant lymphedema must be recognized immediately.
  • The differential diagnosis of regional lymphedema is also part of dermatology.
  • Complications of chronic lymphedema include recurrent erysipelas, superficial lymphangiectases, verrucous lymphedema (papillomatosis lymphostatica) and angiosarcoma, which is often multifocal.
  • Established diagnostic approaches are available to correctly diagnose lymphatic disease.
  • [MeSH-major] Lymphatic Diseases / diagnosis. Lymphatic Diseases / therapy. Lymphatic System / pathology. Lymphatic System / physiopathology. Skin / pathology. Skin / physiopathology. Skin Diseases / diagnosis. Skin Diseases / therapy

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  • (PMID = 15731928.001).
  • [ISSN] 0017-8470
  • [Journal-full-title] Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
  • [ISO-abbreviation] Hautarzt
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 39
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50. Wang ZS, Wang WX, Xiong CL, Zhan N, Li H: Spontaneous ruptured primary hepatic angiosarcoma coincident with Schistosoma Japonica liver fibrosis. Hepatol Res; 2007 Jul;37(7):572-6
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  • [Title] Spontaneous ruptured primary hepatic angiosarcoma coincident with Schistosoma Japonica liver fibrosis.
  • AIM: We report herein a case of spontaneous ruptured primary hepatic angiosarcoma coincident with Schistosoma Japonica liver fibrosis and review the correlative literature.
  • RESULTS: The final diagnosis was spontaneous ruptured primary hepatic angiosarcoma coincident with Schistosoma Japonica liver fibrosis Conclusion: Considering the nature of primary hepatic angiosarcoma, in particular the ruptured hepatic angiosarcoma, it is obviously desirable to avoid any unnecessary delay or definitive surgical treatment.
  • It is presumed that angiosarcoma in the liver has a possible association with S. japonicum and the deposition of ovae in liver.

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  • (PMID = 17540001.001).
  • [ISSN] 1386-6346
  • [Journal-full-title] Hepatology research : the official journal of the Japan Society of Hepatology
  • [ISO-abbreviation] Hepatol. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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51. Kato Y, Asano K, Mizutani I, Konno T, Sasaki Y, Kutara K, Teshima K, Edamura K, Kano R, Suzuki K, Shibuya H, Sato T, Hasegawa A, Tanaka S: Gene expressions of canine angiopoietin-1 and -2 in normal tissues and spontaneous tumours. Res Vet Sci; 2006 Oct;81(2):280-6
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  • Higher mRNA expression level of canine Ang-2 was demonstrated in mammary simple carcinomas, haemangiosarcoma and hepatocellular carcinoma in comparison with normal tissues.
  • [MeSH-minor] Amino Acid Sequence. Animals. Base Sequence. Dogs. Gene Expression. Molecular Sequence Data. Neovascularization, Pathologic / genetics. Neovascularization, Pathologic / metabolism. Neovascularization, Pathologic / veterinary. RNA, Messenger / biosynthesis. RNA, Messenger / genetics. Reverse Transcriptase Polymerase Chain Reaction / veterinary. Sequence Alignment. Vascular Endothelial Growth Factor A / biosynthesis. Vascular Endothelial Growth Factor A / genetics

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  • (PMID = 16545849.001).
  • [ISSN] 0034-5288
  • [Journal-full-title] Research in veterinary science
  • [ISO-abbreviation] Res. Vet. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Angiopoietin-1; 0 / Angiopoietin-2; 0 / RNA, Messenger; 0 / Vascular Endothelial Growth Factor A
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52. Zhang PJ, Brooks JS, Goldblum JR, Yoder B, Seethala R, Pawel B, Gorman JH, Gorman RC, Huang JH, Acker M, Narula N: Primary cardiac sarcomas: a clinicopathologic analysis of a series with follow-up information in 17 patients and emphasis on long-term survival. Hum Pathol; 2008 Sep;39(9):1385-95
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  • [Title] Primary cardiac sarcomas: a clinicopathologic analysis of a series with follow-up information in 17 patients and emphasis on long-term survival.
  • Although cardiac sarcomas are rare in comparison to their soft tissue counterparts, they are the second most common type of primary cardiac neoplasm.
  • A series of 27 cardiac sarcomas removed at surgery for curative and diagnostic intent were reviewed for clinicopathologic features with correlation to available postoperative follow-up data in 17 patients.
  • There were 6 angiosarcomas, 6 myxofibrosarcomas, 3 malignant peripheral nerve sheath tumors, 3 leiomyosarcomas, 2 synovial sarcomas, 1 epithelioid hemangioendothelioma, 1 chondrosarcoma, 1 osteosarcoma, and 4 poorly differentiated sarcomas.
  • In 17 patients with follow-up data, 6 of 12 patients with high-grade tumor died (4 within 5 days of the initial surgery, 1 in 21 months, and 1 in 131 months), and 1 patient with moderate-grade tumor and all 4 patients with low-grade tumor were alive without evidence of disease at the end of follow-up.
  • Tumor grade appeared to be prognostically important in cardiac sarcoma.
  • [MeSH-major] Heart Neoplasms / pathology. Sarcoma / pathology

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  • (PMID = 18602663.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / R01 HL063954
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS522251; NLM/ PMC4081532
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53. Kajo K, Lúcan J, Macháleková K, Beratsová Z: [Cutaneous angiosarcoma following conservative surgery and radiotherapy for breast carcinoma. A case report]. Cesk Patol; 2007 Apr;43(2):59-63
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  • [Title] [Cutaneous angiosarcoma following conservative surgery and radiotherapy for breast carcinoma. A case report].
  • Breast angiosarcomas (AS) are very rare neoplasms, which can be divided into primary (or sporadic), and secondary AS, the latter arising either on the base of lymphoedema after mastectomy (so called AS with Stewart-Treves syndrome- ASSTS), or skin AS after breast conservation surgery with subsequent radiotherapy for breast cancer (KPRAS).
  • The authors present a case of a 55-year-old female patient with a 17mm tumour in nipple region, developing 8 years after primary diagnosis of tubulolobular carcinoma of the breast which was treated by breast conservation surgery and radiotherapy.
  • However, it will be needed to assess in the future new indicators of prognosis of patients with this rare disease.
  • [MeSH-major] Breast Neoplasms / radiotherapy. Breast Neoplasms / surgery. Hemangiosarcoma / etiology. Neoplasms, Second Primary / pathology. Skin Neoplasms / etiology

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  • (PMID = 17623978.001).
  • [ISSN] 1210-7875
  • [Journal-full-title] Československá patologie
  • [ISO-abbreviation] Cesk Patol
  • [Language] slo
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Czech Republic
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54. Ji T, Guo W, Yang R, Tang X: [Short-term outcome of reconstruction for defect after removal of tumor with global modular replacement system]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi; 2010 Oct;24(10):1192-5
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  • The preoperative diagnoses were osteosarcoma in 15 cases, malignant fibro-histiocytoma in 4, giant cell tumor in 3, chondrosarcoma in 2, and Ewing's sarcoma and angiosarcoma in 1 respectively.

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  • (PMID = 21046805.001).
  • [ISSN] 1002-1892
  • [Journal-full-title] Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
  • [ISO-abbreviation] Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] China
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55. Hamid KS, Rodriguez JA, Lairmore TC: Primary splenic angiosarcoma. JSLS; 2010 Jul-Sep;14(3):431-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary splenic angiosarcoma.
  • Primary splenic angiosarcoma is a rare, aggressive malignant neoplasm arising from splenic vascular endothelium.
  • Laparoscopic splenectomy was performed, and a primary splenic angiosarcoma was discovered.
  • After 2 rounds of chemotherapy, a CT scan showed progressive disease with metastasis to the liver and lung.
  • She is currently alive with evidence of disease at 9 months but without further progression.
  • Primary splenic angiosarcoma is almost universally fatal despite treatment.
  • The best chance for survival is early diagnosis and prompt splenectomy prior to splenic rupture.

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  • (PMID = 21333203.001).
  • [ISSN] 1086-8089
  • [Journal-full-title] JSLS : Journal of the Society of Laparoendoscopic Surgeons
  • [ISO-abbreviation] JSLS
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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56. Deyrup AT, Weiss SW: Grading of soft tissue sarcomas: the challenge of providing precise information in an imprecise world. Histopathology; 2006 Jan;48(1):42-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Grading of soft tissue sarcomas: the challenge of providing precise information in an imprecise world.
  • By identifying patients at greatest risk for distant metastasis and, hence, most likely to benefit from adjuvant therapy, the grading of sarcomas has been one of the most important contributions pathologists have made to the treatment of sarcomas.
  • However, no system performs perfectly on all sarcomas.
  • Sarcomas that do not lend themselves well to grading include (i) those in which grade provides no incremental information over histological subtypes (e.g. well-differentiated liposarcoma/atypical lipomatous neoplasm, Ewing's sarcoma);.
  • (ii) tumours traditionally considered "ungradable" (e.g. epithelioid sarcoma, clear cell sarcoma, angiosarcoma); and (iii) sarcomas that customarily have been graded but in which grade has recently been shown not to correlate well with outcome (e.g. malignant peripheral nerve sheath tumour).
  • Consequently, several sarcoma-specific risk stratification schemes have been proposed.
  • Nomograms, which incorporate clinical, histological and demographic findings, have proved accurate in predicting disease-specific survival in sarcomas.
  • Diagnosis and grading are increasingly based on tissue obtained by core needle biopsy, which poses new challenges for pathologists, particularly if neoadjuvant therapy is to be given.
  • [MeSH-major] Soft Tissue Neoplasms / classification. Soft Tissue Neoplasms / diagnosis

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  • (PMID = 16359536.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 37
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57. Ikeda K, Maehara M, Ohmura N, Kurokawa H, Koda K, Yokoyama H, Sawada S: Spontaneous rupture of a necrotic hepatic angiosarcoma: findings on dual-phase computed tomography and angiography. Radiat Med; 2006 Jun;24(5):369-72
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  • [Title] Spontaneous rupture of a necrotic hepatic angiosarcoma: findings on dual-phase computed tomography and angiography.
  • We present dual-phase computed tomographic (CT) and angiographic findings of a ruptured hepatic angiosarcoma.
  • We found that dual-phase CT and angiographic findings are able to distinguish angiosarcoma, which mimics a hemangioma, as these lesions show avascular areas that reflect a mass with gross central necrosis.
  • [MeSH-major] Hemangiosarcoma / diagnostic imaging. Liver Neoplasms / diagnostic imaging. Tomography, X-Ray Computed / methods

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  • (PMID = 16958416.001).
  • [ISSN] 0288-2043
  • [Journal-full-title] Radiation medicine
  • [ISO-abbreviation] Radiat Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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58. Duncan SF, Krochmal DJ, Craft RO, Merritt MV, Smith AA: Epithelioid Hemangioendothelioma of the Distal Radius: A Case Report. Radiol Case Rep; 2007;2(4):119
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  • [Title] Epithelioid Hemangioendothelioma of the Distal Radius: A Case Report.
  • Epithelioid hemangioendothelioma is a rare vascular tumor with cytologic behavior between angiosarcoma and hemangioma.
  • We present the case of a 58-year-old male with primary epithelioid hemangioendothelioma of the distal radius measuring 6.2 × 5 cm with extension into the pronator quadratus and brachioradialis muscles.
  • A review of the clinical, radiographic, and pathologic features of epithelioid hemangioendothelioma is also presented.

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  • (PMID = 27303497.001).
  • [ISSN] 1930-0433
  • [Journal-full-title] Radiology case reports
  • [ISO-abbreviation] Radiol Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Other-IDs] NLM/ PMC4895778
  • [Keywords] NOTNLM ; CT, computed tomography / EH, epithelioid hemangioendothelioma / MRI, magnetic resonance imaging
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59. Hooda S, Humphreys MR, Wong SW, Evans AS: Masson's pseudotumour of the ethmoid sinus - a case report. J Laryngol Otol; 2008 Sep;122(9):990-2
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  • OBJECTIVE: We report a case of Masson's pseudotumour or intravascular papillary endothelial hyperplasia presenting in the ethmoid sinus.
  • CONCLUSION: Intravascular papillary endothelial hyperplasia is a benign, reactive lesion first described by the French pathologist Pierre Masson in 1923.
  • It can lead to diagnostic uncertainty due to its close resemblance clinically, radiologically and histopathologically to angiosarcoma.
  • [MeSH-major] Ethmoid Sinus. Hemangioendothelioma / diagnosis. Paranasal Sinus Neoplasms / diagnosis

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  • (PMID = 17666137.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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61. Kutara K, Asano K, Kito A, Teshima K, Kato Y, Sasaki Y, Edamura K, Shibuya H, Sato T, Hasegawa A, Tanaka S: Contrast harmonic imaging of canine hepatic tumors. J Vet Med Sci; 2006 May;68(5):433-8
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  • In addition, 8 dogs with hepatocellular carcinoma (HCC) and 2 dogs with metastatic hepatic hemangiosarcoma (HSA) were used to characterize both the CHI findings with Levovist.
  • As a characteristic CHI finding in the 8 dogs with HCC, the early arterial phase showed a fine network of blood flow enhanced at the surrounding region and within the tumor in all the 8 dogs (100%), and the post vascular phase demonstrated a defect in the whole tumor and an enhancement of the surrounding hepatic tissues in 7 dogs (87.5%).
  • In the 2 dogs with HSA, characteristic finding in which the early arterial and late vascular phases showed a rim contrast enhancement pattern, and the post vascular phase revealed that the whole tumor lacked contrast enhancement and the surrounding hepatic tissues was clearly enhanced.
  • Therefore, CHI is thought to be useful for the diagnosis of HCC and metastatic hepatic HSA in dogs as well as in humans.

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  • (PMID = 16757885.001).
  • [ISSN] 0916-7250
  • [Journal-full-title] The Journal of veterinary medical science
  • [ISO-abbreviation] J. Vet. Med. Sci.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Polysaccharides; 127279-08-7 / SHU 508
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62. Arbiser JL, Bonner MY, Berrios RL: Hemangiomas, angiosarcomas, and vascular malformations represent the signaling abnormalities of pathogenic angiogenesis. Curr Mol Med; 2009 Nov;9(8):929-34
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  • [Title] Hemangiomas, angiosarcomas, and vascular malformations represent the signaling abnormalities of pathogenic angiogenesis.
  • Angiogenesis is a major factor in the development of benign, inflammatory, and malignant processes of the skin.
  • Endothelial cells are the effector cells of angiogenesis, and understanding their response to growth factors and inhibitors is critical to understanding the pathogenesis and treatment of skin disease.
  • Hemangiomas, benign tumors of endothelial cells, represent the most common tumor of childhood.
  • Furthermore, we have studied malignant vascular tumors, including hemangioendothelioma and angiosarcoma and have shown distinct signaling abnormalities in these tumors.
  • The incidence of these tumors is expected to rise due to environmental insults, such as radiation and lumpectomy for breast cancer, dietary and industrial carcinogens (hepatic angiosarcoma), and chronic ultraviolet exposure and potential Agent Orange exposure.
  • I hypothesize that hemangiomas, angiosarcomas, and vascular malformations represent the extremes of signaling abnormalities seen in pathogenic angiogenesis.
  • [MeSH-major] Hemangioma / blood supply. Hemangiosarcoma / blood supply. Neovascularization, Pathologic / pathology. Signal Transduction. Vascular Malformations / physiopathology


63. Barber W, Scriven P, Turner D, Hughes D, Wyld D: Epithelioid angiosarcoma: Use of angiographic embolisation and radiotherapy to control recurrent haemorrhage. J Surg Case Rep; 2010;2010(5):7
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  • [Title] Epithelioid angiosarcoma: Use of angiographic embolisation and radiotherapy to control recurrent haemorrhage.
  • Epithelioid angiosarcoma is a rare, highly malignant tumour with a poor prognosis.

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  • [Copyright] © JSCR.
  • (PMID = 24946325.001).
  • [ISSN] 2042-8812
  • [Journal-full-title] Journal of surgical case reports
  • [ISO-abbreviation] J Surg Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3649120
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64. Taira N, Ohsumi S, Aogi K, Maeba T, Kawamura S, Nishimura R, Takashima S: Nodular pseudoangiomatous stromal hyperplasia of mammary stroma in a case showing rapid tumor growth. Breast Cancer; 2005;12(4):331-6
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  • Pseudoangiomatous stromal hyperplasia (PASH) is an uncommon benign breast disease that presents as a localized breast mass.
  • The importance of this benign lesion lies in distinguishing it from low grade angiosarcoma.
  • Based on these findings, a provisional diagnosis of fibroadenoma was made and the patient was followed up.
  • Isolated spindle cells appeared intermittently at the margins of the spaces resembled endothelial cells.
  • Immunohistochemical staining showed that endothelial cells lining true blood vessels were positive for Factor VIII-related antigen, but the spindle cells were negative for Factor VIII.
  • [MeSH-minor] Adult. Diagnosis, Differential. Disease Progression. Female. Humans. Hyperplasia. Stromal Cells / pathology


65. Requena L, Luis Díaz J, Manzarbeitia F, Carrillo R, Fernández-Herrera J, Kutzner H: Cutaneous composite hemangioendothelioma with satellitosis and lymph node metastases. J Cutan Pathol; 2008 Feb;35(2):225-30
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  • [Title] Cutaneous composite hemangioendothelioma with satellitosis and lymph node metastases.
  • The term hemangioendothelioma has been used in recent years to name a heterogeneous group of vascular neoplasms, intermediate in both biological behavior and histopathologic appearance between benign tumors (hemangiomas) and frankly malignant tumors (angiosarcomas).
  • Thus, within the spectrum of hemangioendothelioma have been successively included epithelioid hemangioendothelioma, spindle cell hemangioendothelioma, retiform hemangioendothelioma, kaposiform hemangioendothelioma, polymorphous hemagioendothelioma of the lymph nodes, papillary intralymphatic angioendothelioma (PILA) and composite hemangioendothelioma.
  • The latter is a vascular neoplasm showing varying combinations of benign, low-grade malignant and malignant vascular components.
  • We herein report a case of composite hemangioendothelioma showing a combination of retiform hemangioendothelioma, epithelioid hemangioendothelioma, spindle cell hemangioma and PILA.
  • The neoplasm showed a more aggressive behavior than other reported cases of composite hemangioendothelioma and it developed satellitosis and metastases to the inguinal lymph nodes.
  • [MeSH-major] Foot Diseases / pathology. Hemangioendothelioma / pathology. Leg / pathology. Lymphatic Metastasis / pathology. Skin Neoplasms / pathology

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  • (PMID = 18190450.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Homeodomain Proteins; 0 / Tumor Suppressor Proteins; 0 / prospero-related homeobox 1 protein
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66. Ahmad A, Jamieson T, Balsitis M, Diament R: Radiation-induced angiosarcoma of the rectum: a case report and review of literature. Colorectal Dis; 2008 Oct;10(8):847-8
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  • [Title] Radiation-induced angiosarcoma of the rectum: a case report and review of literature.
  • We report a case of rectal angiosarcoma after prostatic radiotherapy, illustrating diagnostic difficulty.
  • Awareness of this potential diagnosis is important with increasing use of radiotherapy in the treatment of pelvic cancers.
  • [MeSH-major] Hemangiosarcoma / etiology. Neoplasms, Radiation-Induced / etiology. Prostatic Neoplasms / radiotherapy. Rectal Neoplasms / etiology

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  • (PMID = 18294267.001).
  • [ISSN] 1463-1318
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 5
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67. Oztürk E, Mutlu H, Sönmez G, Sildiroğlu HO: Primary angiosarcoma of the spleen. Turk J Gastroenterol; 2007 Dec;18(4):272-5
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  • [Title] Primary angiosarcoma of the spleen.
  • Primary angiosarcoma of the spleen is a rare neoplasm with a very poor prognosis.
  • We present computed tomography and magnetic resonance imaging of a 49-year-old man with primary splenic angiosarcoma and liver metastasis.
  • The literature on primary splenic angiosarcoma is reviewed and imaging variability of this rare tumor is discussed.
  • [MeSH-major] Hemangiosarcoma / diagnosis. Splenic Neoplasms / diagnosis

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  • (PMID = 18080928.001).
  • [ISSN] 2148-5607
  • [Journal-full-title] The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
  • [ISO-abbreviation] Turk J Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Turkey
  • [Number-of-references] 23
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68. Good AB, Nascimento A, Welker KM, Arndt CA: Congenital angiosarcoma with transient response to paclitaxel. J Pediatr Hematol Oncol; 2008 Jun;30(6):451-3
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  • [Title] Congenital angiosarcoma with transient response to paclitaxel.
  • Angiosarcoma is a rare diagnosis with a poor prognosis.
  • We report the first known case of congenital angiosarcoma.
  • We also report a transient response with paclitaxel, an agent that may have a role in unresectable angiosarcoma.
  • [MeSH-major] Antineoplastic Agents, Phytogenic / therapeutic use. Head and Neck Neoplasms / congenital. Head and Neck Neoplasms / drug therapy. Hemangiosarcoma / congenital. Hemangiosarcoma / drug therapy. Paclitaxel / therapeutic use
  • [MeSH-minor] Diagnosis, Differential. Fatal Outcome. Female. Humans. Immunohistochemistry. Infant. Lymphangioma, Cystic / pathology

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  • (PMID = 18525462.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; P88XT4IS4D / Paclitaxel
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69. Jowett AJ, Parvin SD: Angiosarcoma in an area of lipodermatosclerosis. Ann R Coll Surg Engl; 2008 Jul;90(5):W15-6
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  • [Title] Angiosarcoma in an area of lipodermatosclerosis.
  • An area within this broke down as a result of an angiosarcoma rather than the more probable: formation of a venous ulcer.
  • [MeSH-major] Hemangiosarcoma / etiology. Leg Ulcer / complications. Skin Neoplasms / etiology

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70. Liu J, Waalkes MP: Liver is a target of arsenic carcinogenesis. Toxicol Sci; 2008 Sep;105(1):24-32
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  • Hepatocellular carcinoma and hepatic angiosarcoma, have been frequently associated with environmental or medicinal exposure to arsenicals.
  • Chronic exposure of rat liver epithelial cells to low concentrations of inorganic arsenic induces malignant transformation, producing aggressive, undifferentiated epithelial tumors when inoculated into the Nude mice.

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  • (PMID = 18566022.001).
  • [ISSN] 1096-0929
  • [Journal-full-title] Toxicological sciences : an official journal of the Society of Toxicology
  • [ISO-abbreviation] Toxicol. Sci.
  • [Language] ENG
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Estrogens; N712M78A8G / Arsenic
  • [Number-of-references] 86
  • [Other-IDs] NLM/ PMC2734307
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71. Smigla GR, Lawson DS, Kaemmer DD, Shearer IR: Venous line filtration: a novel technique for cases involving inferior vena caval and right atrial tumor and associated thrombus: a two-case series. Perfusion; 2006 Nov;21(6):391-4
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  • The second case was a 37-year-old male (95 kg, 178 cm, BSA 2.17 m2), who presented with a very large angiosarcoma tumor involving almost the entire right atrium.
  • [MeSH-major] Heart Neoplasms / surgery. Hemangiosarcoma / surgery. Intraoperative Complications / prevention & control. Neoplastic Cells, Circulating. Vena Cava Filters

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  • (PMID = 17312864.001).
  • [ISSN] 0267-6591
  • [Journal-full-title] Perfusion
  • [ISO-abbreviation] Perfusion
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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72. Catalano O, Sandomenico F, Raso MM, Siani A: Real-time, contrast-enhanced sonography: a new tool for detecting active bleeding. J Trauma; 2005 Oct;59(4):933-9
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  • These included spleen injury (n = 8), liver injury (n = 3), kidney injury (n = 1), abdominal aortic aneurysm rupture (n = 5), splenic angiosarcoma rupture (n = 1), postsurgical bleeding after abdominal aortic aneurysm repair (n = 1), and postsplenectomy bleeding (n = 1).

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  • (PMID = 16374284.001).
  • [ISSN] 0022-5282
  • [Journal-full-title] The Journal of trauma
  • [ISO-abbreviation] J Trauma
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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73. Yoshida K, Ito F, Nakazawa H, Maeda Y, Tomoe H, Aiba M: A case of primary renal angiosarcoma. Rare Tumors; 2009;1(2):e28
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  • [Title] A case of primary renal angiosarcoma.
  • The initial pathological diagnosis was a benign chronic hematoma.
  • The renal specimen was re-evaluated using whole cross-section analysis and immunohistochemistry, and diagnosed as a primary renal angiosarcoma.
  • Recombinant interleukin-2 therapy was started immediately; however, the patient died of metastatic disease 13 months after the initial operation.
  • Although contrast imaging depicted the primary lesion as a non-specific hematoma with little focal pooling, and low-grade cytological atypia was shown pathologically, the angiosarcoma was extremely aggressive.

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  • (PMID = 21139907.001).
  • [ISSN] 2036-3613
  • [Journal-full-title] Rare tumors
  • [ISO-abbreviation] Rare Tumors
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2994470
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74. Ishiguro N, Motoi T, Araki N, Ito H, Moriyama M, Yoshida H: Expression of cardiac ankyrin repeat protein, CARP, in malignant tumors: diagnostic use of CARP protein immunostaining in rhabdomyosarcoma. Hum Pathol; 2008 Nov;39(11):1673-9
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  • [Title] Expression of cardiac ankyrin repeat protein, CARP, in malignant tumors: diagnostic use of CARP protein immunostaining in rhabdomyosarcoma.
  • Arpp, a close homolog of CARP, has been demonstrated to be useful for distinguishing rhabdomyosarcoma from other malignant tumors.
  • However, the CARP distributions among malignant tumors have been poorly investigated.
  • Here, we analyzed the comprehensive expression of CARP in malignant tumors and evaluated its potential use for rhabdomyosarcoma diagnosis.
  • A total of 159 malignant tumors, including 34 rhabdomyosarcomas, 85 non-rhabdomyosarcomas, and 40 carcinomas, were immunohistochemically analyzed for CARP expression.
  • In contrast, focal immunoreactivity for CARP was only observed in 5 (4%) of 125 non-rhabdomyosarcomas, comprising 2 malignant fibrous histiocytomas, 1 angiosarcoma, 1 epithelioid sarcoma, and 1 squamous cell carcinoma of the lung.
  • Our results indicate that CARP is a sensitive and specific marker for rhabdomyosarcoma and that it will be useful for the differential diagnosis of rhabdomyosarcoma.
  • [MeSH-major] Biomarkers, Tumor / analysis. Muscle Proteins / biosynthesis. Nuclear Proteins / biosynthesis. Repressor Proteins / biosynthesis. Rhabdomyosarcoma / diagnosis. Rhabdomyosarcoma / metabolism

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  • (PMID = 18656235.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ANKRD1 protein, human; 0 / Biomarkers, Tumor; 0 / Muscle Proteins; 0 / Nuclear Proteins; 0 / Repressor Proteins
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75. Bolt HM: Vinyl chloride-a classical industrial toxicant of new interest. Crit Rev Toxicol; 2005 Apr-May;35(4):307-23
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  • The carcinogenicity of vinyl chloride in humans was recognized in 1974 based on observations of hepatic angiosarcomas in highly exposed workers.
  • Vinyl chloride is a pluripotent carcinogen, predominantly directed toward hepatic endothelial (sinusoidal) cells, and second toward the parenchymal cells of the liver.
  • This is consistent with the plateau of hepatic angiosarcoma incidence in rat bioassays.
  • Published risk estimates based on different sets of data (animal experiments, epidemiological studies) appear basically consistent, and on this basis an angiosarcoma risk of approximately 3 x 10(-4) has been deduced by extrapolation, for exposure to 1 ppm vinyl chloride over an entire human working lifetime.

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  • (PMID = 15989139.001).
  • [ISSN] 1040-8444
  • [Journal-full-title] Critical reviews in toxicology
  • [ISO-abbreviation] Crit. Rev. Toxicol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens; 0 / Mutagens; 9007-49-2 / DNA; WD06X94M2D / Vinyl Chloride
  • [Number-of-references] 170
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76. Lamerato-Kozicki AR, Helm KM, Jubala CM, Cutter GC, Modiano JF: Canine hemangiosarcoma originates from hematopoietic precursors with potential for endothelial differentiation. Exp Hematol; 2006 Jul;34(7):870-8
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  • [Title] Canine hemangiosarcoma originates from hematopoietic precursors with potential for endothelial differentiation.
  • OBJECTIVE: Two competing hypotheses can be formulated regarding the origin of canine hemangiosarcoma (HSA).
  • One states HSA originates from differentiated vascular endothelial cells that undergo mutations which endow them with malignant potential.
  • This study was designed to begin to distinguish between these possibilities, as well as to test if flow cytometry was sufficiently sensitive to detect malignant cells in blood samples from dogs with HSA.
  • RESULTS: The data show that HSA cells coexpress surface markers associated with hematopoietic precursors and with commitment to endothelial lineage, providing a means to identify their presence in circulation and distinguish them from normal or malignant white blood cells.
  • In addition, these expression patterns may assist to confirm an HSA diagnosis, monitor minimal residual disease, and detect the disease in early stages.
  • [MeSH-major] Cell Differentiation. Hemangiosarcoma / pathology


77. Kiyozuka Y, Koyama H, Nakata M, Matsuyama T, Nikaido Y, Shimano N, Tsubura A: Diagnostic cytopathology in type II angiosarcoma of the breast: a case report. Acta Cytol; 2005 Sep-Oct;49(5):560-6
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  • [Title] Diagnostic cytopathology in type II angiosarcoma of the breast: a case report.
  • BACKGROUND: The rare occurrence of angiosarcoma of the breast is reflected in limited descriptions of fine needle aspiration (FNA) cytomorphologic findings in this neoplasm.
  • We present a case of angiosarcoma of the breast and discuss the pitfalls in diagnostic cytopathology that can potentially lead to incorrect diagnoses in such cases.
  • The overall cytologic diagnosis was inconclusive but suggested phyllodes tumor (of borderline malignancy).
  • Histologic features were consistent with angiosarcoma, a diagnosis that was supported by immunohistochemical studies.
  • CONCLUSION: On FNA smear, 49.1% of isolated atypical cells were positive for the endothelial marker CD34; however, cytomorphologic appearance of these cells resembled that of CD34-negative active mesenchymal cells.
  • Angiosarcoma rarely occurs in the breast, and a definitive diagnosis is difficult based on cytologic examination of hypocellular smears alone.
  • [MeSH-major] Blood Vessels / pathology. Breast Neoplasms / pathology. Hemangiosarcoma / pathology. Mammary Glands, Human / blood supply. Mammary Glands, Human / pathology
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Biopsy, Fine-Needle. Endothelial Cells / pathology. Epithelial Cells / pathology. Female. Fibroblasts / pathology. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Mammography. Mastectomy. Middle Aged. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 16334037.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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78. Pai MR, Upadhyaya K, Naik R, Malhotra S: Bilateral angiosarcoma breast diagnosed by fine needle aspiration cytology. Indian J Pathol Microbiol; 2008 Jul-Sep;51(3):421-3
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  • [Title] Bilateral angiosarcoma breast diagnosed by fine needle aspiration cytology.
  • Concurrent or synchronous angiosarcoma (AS) of breast is a rarity.
  • Specific recognition of this neoplasm in cytological specimens is difficult and conclusive diagnosis in the absence of ancillary methods is achieved only uncommonly.
  • This case report emphasizes that when aspiration smears show vasoformative features consisting of microacini, arborizing microtissue fragments and intracytoplasmic lumen against a bloody background, diagnosis can be made conclusively by FNA with immunohistochemical confirmation.
  • [MeSH-major] Breast Neoplasms / diagnosis. Hemangiosarcoma / diagnosis

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  • (PMID = 18723979.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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79. Amonkar GP, Deshpande JR: Cardiac angiosarcoma. Cardiovasc Pathol; 2006 Jan-Feb;15(1):57-8
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  • [Title] Cardiac angiosarcoma.
  • Myxoma is the most common primary cardiac tumor, while angiosarcoma is the commonest primary malignant tumor.
  • A malignant mass was seen arising in the right atrium, with pericardial effusion and multiple metastases in the lung.
  • A complete autopsy was performed and a diagnosis of cardiac angiosarcoma was confirmed on histology and immunohistochemistry.
  • [MeSH-major] Heart Neoplasms / pathology. Hemangiosarcoma / secondary

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  • (PMID = 16414459.001).
  • [ISSN] 1054-8807
  • [Journal-full-title] Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology
  • [ISO-abbreviation] Cardiovasc. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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80. Al Dhaybi R, Powell J, McCuaig C, Kokta V: Differentiation of vascular tumors from vascular malformations by expression of Wilms tumor 1 gene: evaluation of 126 cases. J Am Acad Dermatol; 2010 Dec;63(6):1052-7
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  • METHODS: Based on the International Society for the Study of Vascular Anomalies classification of vascular anomalies, we studied the expression of WT1 in vascular tumors composed of infantile hemangioma, congenital hemangiomas (non-involuting, rapidly involuting, and not otherwise specified), pyogenic granuloma, tufted angioma, cherry angioma, Kaposi sarcoma, and angiosarcoma.
  • RESULTS: All vascular tumors and proliferations had positive WT1 cytoplasmic endothelial immunostaining whereas only 3 vascular malformations were WT1 positive.
  • LIMITATIONS: The low number of malignant vascular tumors is a limitation.
  • [MeSH-minor] Adolescent. Adult. Aged. Biopsy. Cell Division / physiology. Child. Child, Preschool. Cytoplasm / metabolism. Diagnosis, Differential. Humans. Immunohistochemistry. Infant. Infant, Newborn. Middle Aged. Young Adult


81. Butrón Vila T, García Villar O, Alonso García S, Bonachia Naranjo O, Pérez Espejo G, Lomas Espadas M, Hidalgo Pascual M: Angiosarcoma in the small intestine. Apropos of a particular case. Hepatogastroenterology; 2005 Jul-Aug;52(64):1139-42
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  • [Title] Angiosarcoma in the small intestine. Apropos of a particular case.
  • Presentation of a case of small intestine primary angiosarcoma in a 70-year-old male.
  • An immunohistochemical study is usually essential for its anatomopathological diagnosis.
  • The diagnosis is generally arrived at in its advanced stages, and that makes for a bad prognosis.
  • [MeSH-major] Hemangiosarcoma / pathology. Ileal Neoplasms / pathology

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  • (PMID = 16001647.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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82. Heo SH, Jeong YY, Shin SS, Chung TW, Kang HK: Solitary small hepatic angiosarcoma: initial and follow-up imaging findings. Korean J Radiol; 2007 Mar-Apr;8(2):180-3
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  • [Title] Solitary small hepatic angiosarcoma: initial and follow-up imaging findings.
  • We report an uncommon case of solitary, small hepatic angiosarcoma that was initially considered as a hemangioma.
  • We present the imaging findings, with an emphasis on the initial and follow-up CT and MR findings, as well as report on the more suggestive findings of angiosarcoma than those of a hemangioma.
  • [MeSH-major] Hemangiosarcoma / diagnosis. Liver Neoplasms / diagnosis
  • [MeSH-minor] Contrast Media. Diagnosis, Differential. Gadolinium DTPA. Hemangioma / diagnosis. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 17420638.001).
  • [ISSN] 1229-6929
  • [Journal-full-title] Korean journal of radiology
  • [ISO-abbreviation] Korean J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Contrast Media; K2I13DR72L / Gadolinium DTPA
  • [Other-IDs] NLM/ PMC2626776
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83. Del Rio P, Cataldo S, Sommaruga L, Corcione L, Guazzi A, Sianesi M: A rare case of thyroid haemangiosarcoma. Chir Ital; 2007 Sep-Oct;59(5):747-9
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  • [Title] A rare case of thyroid haemangiosarcoma.
  • The incidence of haemangiosarcoma in the literature is variable especially in the Alpine region and in Austria, ranging from 2 to 10% of all thyroid neoplastic lesions.
  • This thyroid disease is characterised by positive endothelial markers (CD 31, CD 34 and FVIII), and co-positive markers for cytokeratins, epithelial membrane antigen and a loss of thyroglobulin can sometimes be found.
  • Immunochemistry does not help the physician to classify the neoplasia as a variant of anaplastic carcinoma or sarcoma of endothelial origin.
  • We present a case of epithelioid haemangiosarcoma in an elderly woman from outside the Alpine region with a contralateral papillary cancer treated by total thyroidectomy.
  • [MeSH-major] Hemangiosarcoma. Thyroid Neoplasms

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  • (PMID = 18019649.001).
  • [ISSN] 0009-4773
  • [Journal-full-title] Chirurgia italiana
  • [ISO-abbreviation] Chir Ital
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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84. Huang J, Bouvette MJ, Zhou J, Dwyer GJ 3rd, Bhopatkar S, Bhatia A: A large angiosarcoma of the right atrium. Anesth Analg; 2009 Jun;108(6):1755-7
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  • [Title] A large angiosarcoma of the right atrium.
  • [MeSH-major] Heart Neoplasms / ultrasonography. Hemangiosarcoma / ultrasonography

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  • (PMID = 19448197.001).
  • [ISSN] 1526-7598
  • [Journal-full-title] Anesthesia and analgesia
  • [ISO-abbreviation] Anesth. Analg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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85. Agarwal PP, Dennie CJ, Matzinger FR, Peterson RA, Seely JM: Pulmonary artery pseudoaneurysm secondary to metastatic angiosarcoma. Thorax; 2006 Apr;61(4):366
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  • [Title] Pulmonary artery pseudoaneurysm secondary to metastatic angiosarcoma.
  • [MeSH-major] Aneurysm, False / radiography. Head and Neck Neoplasms. Hemangiosarcoma / secondary. Lung Neoplasms / secondary. Pulmonary Artery / radiography. Soft Tissue Neoplasms

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  • [Cites] AJR Am J Roentgenol. 2003 Jun;180(6):1671-4 [12760941.001]
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  • (PMID = 16565273.001).
  • [ISSN] 0040-6376
  • [Journal-full-title] Thorax
  • [ISO-abbreviation] Thorax
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2104616
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86. Zhou ML, Yan FH, Ye F, Xiong Z, Wang JH, Ji Y: [Images of primary hepatic angiosarcomas]. Zhonghua Gan Zang Bing Za Zhi; 2008 Feb;16(2):136-7
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  • [Title] [Images of primary hepatic angiosarcomas].
  • [MeSH-major] Hemangiosarcoma / radiography. Liver Neoplasms / radiography. Tomography, X-Ray Computed

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  • (PMID = 18304433.001).
  • [ISSN] 1007-3418
  • [Journal-full-title] Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology
  • [ISO-abbreviation] Zhonghua Gan Zang Bing Za Zhi
  • [Language] chi
  • [Publication-type] Journal Article
  • [Publication-country] China
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87. Berretta M, Rupolo M, Buonadonna A, Canzonieri V, Brollo A, Morra A, Berretta S, Bearz A, Tirelli U, Frustaci S: Metastatic angiosarcoma of the kidney: a case report with treatment approach and review of the literature. J Chemother; 2006 Apr;18(2):221-4
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  • [Title] Metastatic angiosarcoma of the kidney: a case report with treatment approach and review of the literature.
  • Angiosarcomas are rare soft tissue malignancies.
  • Typically they originate from the skin of the scalp or face, whereas visceral sarcomas are very rare.
  • We report the case of a 67-year-old man affected by a large angiosarcoma of the kidney.
  • Palliative chemotherapy, based on anthracycline and ifosfamide, which are normally used to treat all other high-grade spindle cell sarcomas, was totally inactive.
  • Antiangiogenetic agents are of interest for this disease due to the peculiar origin of the cells of these sarcomas.
  • [MeSH-major] Hemangiosarcoma / drug therapy. Hemangiosarcoma / surgery. Kidney Neoplasms / drug therapy. Kidney Neoplasms / surgery

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  • Hazardous Substances Data Bank. IFOSFAMIDE .
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  • (PMID = 16736893.001).
  • [ISSN] 1120-009X
  • [Journal-full-title] Journal of chemotherapy (Florence, Italy)
  • [ISO-abbreviation] J Chemother
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Anthracyclines; UM20QQM95Y / Ifosfamide
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88. Sledge DG, Radi ZA, Miller DL, Lynn BS: Subcutaneous haemangiosarcoma in a cockatiel (Nymphicus hollandicus). J Vet Med A Physiol Pathol Clin Med; 2006 Aug;53(6):293-5
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  • [Title] Subcutaneous haemangiosarcoma in a cockatiel (Nymphicus hollandicus).
  • Neoplastic cells had diffuse immunoreactivity to factor VIII supporting a diagnosis of haemangiosarcoma.
  • [MeSH-major] Bird Diseases / diagnosis. Cockatoos. Hemangiosarcoma / veterinary. Skin Neoplasms / veterinary

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  • (PMID = 16901272.001).
  • [ISSN] 0931-184X
  • [Journal-full-title] Journal of veterinary medicine. A, Physiology, pathology, clinical medicine
  • [ISO-abbreviation] J Vet Med A Physiol Pathol Clin Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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89. Abularrage CJ, Weiswasser JM, White PW, Arora S, Sidawy AN: Aortic angiosarcoma presenting as distal arterial embolization. Ann Vasc Surg; 2005 Sep;19(5):744-8
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  • [Title] Aortic angiosarcoma presenting as distal arterial embolization.
  • Aortic angiosarcoma is a rare, malignant neoplasm of the vasculature, with 24 case reports in the literature.
  • Patients usually present with either aneurysmal or occlusive disease.
  • Despite surgery and adjunctive measures, prognosis remains dismal as a result of early metastasis and late diagnosis.
  • We report a case of aortic angiosarcoma that presented with distal thromboembolic phenomenon.
  • [MeSH-major] Aorta. Hemangiosarcoma / diagnosis. Neoplastic Cells, Circulating. Tibial Arteries. Vascular Neoplasms / diagnosis
  • [MeSH-minor] Aged. Arterial Occlusive Diseases / diagnosis. Arterial Occlusive Diseases / etiology. Arterial Occlusive Diseases / surgery. Blood Vessel Prosthesis Implantation. Fatal Outcome. Humans. Male. Thrombectomy

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  • (PMID = 16027993.001).
  • [ISSN] 0890-5096
  • [Journal-full-title] Annals of vascular surgery
  • [ISO-abbreviation] Ann Vasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 26
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90. Akiyama T, Hamazaki S, Monobe Y, Nishimura H, Irei I, Sadahira Y: Sphingosine-1-phosphate receptor 1 is a useful adjunct for distinguishing vascular neoplasms from morphological mimics. Virchows Arch; 2009 Feb;454(2):217-22
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  • Sphingosine-1-phosphate receptor 1 (S1P(1)) has been shown to play an important role in the migration, proliferation, and survival of endothelial cells.
  • S1P(1) of vascular and lymphatic endothelial cells can be detected by immunostaining of paraffin-embedded sections using a rabbit anti-S1P(1) antibody.
  • S1P(1) expression was observed in eight of eight hemangiomas, four of four lymphangiomas, four of four epithelioid hemangioendotheliomas, three of three Kaposi's sarcomas, and 15 of 15 angiosarcomas with vasoformative, spindle, epithelioid, and undifferentiated features.
  • Conventional analysis and use of a tissue microarray of soft tissue tumors revealed three of 21 liposarcomas to have weak cytoplasmic staining and one of five squamous cell carcinomas to have membranous staining in a very limited area among 115 nonvascular tumors including histological mimics of angiosarcoma such as undifferentiated carcinoma, melanoma, and epithelioid sarcoma.
  • The sensitivity with regards to the angiosarcoma cases was equal to, or even exceeded in undifferentiated angiosarcoma, that of CD31.
  • Based on this study, S1P(1) may be a useful adjunct to CD31 in cases where a vascular neoplasm requires a differential diagnosis.
  • [MeSH-major] Biomarkers, Tumor / analysis. Neoplasms, Vascular Tissue / diagnosis. Receptors, Lysosphingolipid / analysis
  • [MeSH-minor] Adult. Aged. Female. Hemangioma / diagnosis. Hemangiosarcoma / diagnosis. Humans. Immunohistochemistry. Lymphangioma / diagnosis. Male. Middle Aged

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  • (PMID = 19005676.001).
  • [ISSN] 1432-2307
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Receptors, Lysosphingolipid
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91. Zhu XW, Guo JP, Chen H, Ren GP, Li FY, Fang JJ, Zhong DC: [Deep sarcoma of the penis: a report of 2 cases and review of the literature]. Zhonghua Nan Ke Xue; 2007 Oct;13(10):915-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Deep sarcoma of the penis: a report of 2 cases and review of the literature].
  • OBJECTIVE: To investigate the clinical characteristics, diagnosis, treatment and prognosis of deep sarcoma of the penis.
  • METHODS: The pathological and clinical data of 2 cases of deep sarcoma of the penis were analyzed retrospectively and the literature reviewed.
  • Epithelioid angiosarcoma of the penis was confirmed by postoperative pathology in one patient, who died of pulmonary metastasis in the eighth month after the operation; and epithelioid sarcoma of the penis was confirmed in the other, who died of brain metastasis in the second month after the operation.
  • CONCLUSION: Deep sarcoma of the penis is rare but can be diagnosed pathologically.
  • [MeSH-major] Penile Neoplasms / diagnosis. Penile Neoplasms / surgery. Sarcoma / diagnosis. Sarcoma / surgery

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  • (PMID = 17977325.001).
  • [ISSN] 1009-3591
  • [Journal-full-title] Zhonghua nan ke xue = National journal of andrology
  • [ISO-abbreviation] Zhonghua Nan Ke Xue
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 10
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92. Albert A, Lootvoet L, Lejeune E, Beugnies A, Himmer O: Angiosarcoma around a knee arthroplasty. Report of a case and literature review. Acta Orthop Belg; 2009 Aug;75(4):549-53
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  • [Title] Angiosarcoma around a knee arthroplasty. Report of a case and literature review.
  • We report a case of tibial angiosarcoma, an extremely rare malignancy, which developed in proximity to a primary knee arthroplasty performed ten years before.
  • While implantation of orthopaedic material can induce the development of malignant tumours in experimental animals, the overall incidence of malignancy recorded following arthroplasty in clinical studies does not appear to be increased compared to the control population.
  • [MeSH-major] Arthroplasty, Replacement, Knee. Hemangiosarcoma / etiology. Soft Tissue Neoplasms / etiology

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  • (PMID = 19774826.001).
  • [ISSN] 0001-6462
  • [Journal-full-title] Acta orthopaedica Belgica
  • [ISO-abbreviation] Acta Orthop Belg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Belgium
  • [Number-of-references] 24
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93. Carpino F, Pezzoli F, Petrozza V, Carpino G, Evangelista A, Mutone D, Reali M, Gaudio C: Angiosarcoma of the heart: structural and ultrastructural study. Eur Rev Med Pharmacol Sci; 2005 Jul-Aug;9(4):231-40
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  • [Title] Angiosarcoma of the heart: structural and ultrastructural study.
  • The most frequent primary cardiac neoplasm is the angiosarcoma that represents 31% of primary cardiac malignant.
  • We report a particular clinical case of cardiac angiosarcoma, its light and transmission electron microscopic aspects and a review of the recent literature.
  • The presence of blood-filled lumina and the identification of typical markers of endothelial cells seems to indicate a well-differentiated nature.
  • [MeSH-major] Heart Neoplasms / pathology. Hemangiosarcoma / pathology

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  • (PMID = 16128044.001).
  • [ISSN] 1128-3602
  • [Journal-full-title] European review for medical and pharmacological sciences
  • [ISO-abbreviation] Eur Rev Med Pharmacol Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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94. Dogliotti E: Molecular mechanisms of carcinogenesis by vinyl chloride. Ann Ist Super Sanita; 2006;42(2):163-9
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  • In 1974 vinyl chloride (VC), a gas used in the plastics industry, was shown to be a human carcinogen, inducing a very rare type of tumor, angiosarcoma of the liver.

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  • (PMID = 17033136.001).
  • [ISSN] 0021-2571
  • [Journal-full-title] Annali dell'Istituto superiore di sanità
  • [ISO-abbreviation] Ann. Ist. Super. Sanita
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Carcinogens; WD06X94M2D / Vinyl Chloride
  • [Number-of-references] 60
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95. Tan SM, Tay YK, Liu TT, Mancer K: Cutaneous angiosarcoma associated with the Kasabach-Merritt syndrome. Ann Acad Med Singapore; 2010 Dec;39(12):941-2
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  • [Title] Cutaneous angiosarcoma associated with the Kasabach-Merritt syndrome.
  • [MeSH-major] Hemangiosarcoma / etiology

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  • (PMID = 21274494.001).
  • [ISSN] 0304-4602
  • [Journal-full-title] Annals of the Academy of Medicine, Singapore
  • [ISO-abbreviation] Ann. Acad. Med. Singap.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Singapore
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96. Furusawa T, Matsumoto I, Oda M, Yachi T, Miyazu K, Watanabe G, Zen Y, Minato H, Shibata Y, Koda W: [Intractable pneumothorax secondary to pulmonary metastasis of angiosarcoma]. Kyobu Geka; 2008 Aug;61(9):779-83
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  • [Title] [Intractable pneumothorax secondary to pulmonary metastasis of angiosarcoma].
  • He had a previous history of angiosarcoma of the scalp, and had received local resection and chemoradiotherapy.
  • Although surgical resection for pneumothorax secondary to metastatic lung cancer is usually efficient, it is very hard to manage the pneumothorax of metastatic angiosarcoma.
  • [MeSH-major] Hemangiosarcoma / pathology. Lung Neoplasms / complications. Lung Neoplasms / secondary. Pneumothorax / etiology. Scalp. Skin Neoplasms / pathology

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  • (PMID = 18697460.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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97. Hardisty JF, Elwell MR, Ernst H, Greaves P, Kolenda-Roberts H, Malarkey DE, Mann PC, Tellier PA: Histopathology of hemangiosarcomas in mice and hamsters and liposarcomas/fibrosarcomas in rats associated with PPAR agonists. Toxicol Pathol; 2007 Dec;35(7):928-41
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  • [Title] Histopathology of hemangiosarcomas in mice and hamsters and liposarcomas/fibrosarcomas in rats associated with PPAR agonists.
  • Since the most commonly observed tumor types reported in rodents are hemangiosarcomas, fibrosarcomas and liposarcomas, the PPAR Agonist Project Committee approved a Pathology Working Group (PWG) to develop consensus of morphologic criteria for tumor diagnoses and consistency of diagnoses across multiple studies for hemangiosarcomas in mice and hamsters and liposarcomas/fibrosarcomas in rats.
  • Therefore, the focus of the PWG review was to establish consistent tumor diagnostic criteria, to assess evidence of potentially preneoplastic changes and to identify distinguishing morphologic differences which may exist between spontaneous changes present in control animals with similar changes from treated animals.
  • [MeSH-major] Fibrosarcoma / chemically induced. Hemangiosarcoma / chemically induced. Liposarcoma / chemically induced. Peroxisome Proliferator-Activated Receptors / agonists


98. U'Ren LW, Biller BJ, Elmslie RE, Thamm DH, Dow SW: Evaluation of a novel tumor vaccine in dogs with hemangiosarcoma. J Vet Intern Med; 2007 Jan-Feb;21(1):113-20
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  • [Title] Evaluation of a novel tumor vaccine in dogs with hemangiosarcoma.
  • BACKGROUND: Hemangiosarcoma (HSA) is a highly metastatic and often rapidly fatal tumor of dogs.


99. Weed BR, Folpe AL: Cutaneous CD30-positive epithelioid angiosarcoma following breast-conserving therapy and irradiation: a potential diagnostic pitfall. Am J Dermatopathol; 2008 Aug;30(4):370-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cutaneous CD30-positive epithelioid angiosarcoma following breast-conserving therapy and irradiation: a potential diagnostic pitfall.
  • A case of cutaneous epithelioid angiosarcoma with anomalous CD30 expression, occurring after breast-conserving surgery and adjuvant irradiation, is reported.
  • The differential diagnosis of CD30 epithelioid angiosarcoma is discussed.
  • [MeSH-major] Antigens, CD30 / biosynthesis. Hemangiosarcoma / metabolism. Neoplasms, Radiation-Induced / metabolism. Neoplasms, Second Primary / metabolism. Skin Neoplasms / metabolism
  • [MeSH-minor] Aged, 80 and over. Breast Neoplasms / radiotherapy. Breast Neoplasms / surgery. Carcinoma, Ductal, Breast / radiotherapy. Carcinoma, Ductal, Breast / surgery. Combined Modality Therapy. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Lymphoma, Large-Cell, Anaplastic / pathology. Radiotherapy, Adjuvant / adverse effects

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  • (PMID = 18645308.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD30
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100. Alvite Canosa M, Alonso Fernández L, Seoane Vigo M, Berdeal Díaz M, Pérez Grobas J, Bouzón Alejandro A, Carral Freire M, de Llano Monelos P, Gómez Freijoso C: [Primary angiosarcoma of the spleen]. Rev Esp Enferm Dig; 2008 Jun;100(6):375-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Primary angiosarcoma of the spleen].
  • [Transliterated title] Angiosarcoma primario de bazo.
  • [MeSH-major] Hemangiosarcoma. Splenic Neoplasms

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  • (PMID = 18752372.001).
  • [ISSN] 1130-0108
  • [Journal-full-title] Revista española de enfermedades digestivas : organo oficial de la Sociedad Española de Patología Digestiva
  • [ISO-abbreviation] Rev Esp Enferm Dig
  • [Language] spa
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Spain
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