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Items 1 to 100 of about 1135
1. Hillock R, Lainchbury J, Robinson B: Images in cardiology: Cardiac angiosarcoma: diagnosis by coronary angiography. Heart; 2005 Oct;91(10):1270

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Images in cardiology: Cardiac angiosarcoma: diagnosis by coronary angiography.
  • [MeSH-major] Heart Neoplasms / radiography. Hemangiosarcoma / radiography

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  • (PMID = 16162611.001).
  • [ISSN] 1468-201X
  • [Journal-full-title] Heart (British Cardiac Society)
  • [ISO-abbreviation] Heart
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1769124
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2. Silvariño R, Mérola V, Fígoli L, Romero C, Lapiedra J, Alonso J: [Stewart-Treves syndrome: report of one case]. Rev Med Chil; 2010 Jan;138(1):73-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Angiosarcomas are malignant tumors derived from the endothelium of blood vessel (hemangiosarcomas) or lymph vessels (lymphangiosarcomas).
  • We report a 40-year-old mole with an angiosarcoma associated with primary chronic lower limb lymph edema.
  • A biopsy of one of the skin lesions disclosed an angiosarcoma, diagnosis that was confirmed with immuno-histochemistry Chemotherapy was started but the patient died five months after the diagnosis.

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  • (PMID = 20361154.001).
  • [ISSN] 0034-9887
  • [Journal-full-title] Revista médica de Chile
  • [ISO-abbreviation] Rev Med Chil
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Chile
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3. Kinderyte R, Alisauskaite L, Juodzbaliene EB, Juozaityte E: [Angiosarcoma of the breast: a case report and literature review]. Medicina (Kaunas); 2006;42(7):580-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Angiosarcoma of the breast: a case report and literature review].
  • [Transliterated title] Krūties angiosarkoma.
  • Sarcoma of the breast is a rare tumor (makes up 0.5 to 1% of all malignant breast tumors).
  • In literature, only isolated cases of primary angiosarcoma of the breast were described.
  • Secondary angiosarcomas are more frequently diagnosed in women and mostly in patients who underwent breast-conserving surgery and were treated by radiotherapy.
  • In this article a very rare case of angiosarcoma of the breast is presented.
  • After surgery the diagnosis of hematoma was made.
  • After review of histopathology slides the likely diagnosis of angiosarcoma of the breast was made.
  • A patient from the time of diagnosis survived for 8 months.
  • The mean survival of patients with angiosarcoma of the breast, described in literature, ranges from 13 to 22 months, and the treatment in this case most likely could not have an effect on survival of the patient.
  • [MeSH-major] Breast Neoplasms. Hemangiosarcoma
  • [MeSH-minor] Adult. Breast / pathology. Diagnosis, Differential. Female. Humans. Lung Neoplasms / radiography. Lung Neoplasms / secondary. Lymphatic Metastasis / diagnosis. Mastectomy, Simple. Prognosis. Radiography, Thoracic. Time Factors

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  • (PMID = 16861841.001).
  • [ISSN] 1648-9144
  • [Journal-full-title] Medicina (Kaunas, Lithuania)
  • [ISO-abbreviation] Medicina (Kaunas)
  • [Language] lit
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Lithuania
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4. Peramiquel L, Barnadas MA, Sancho J, Curell R, Alonso MC, Fuentes MJ, Pernas S, Gómez A, Alomar A: [Angiosarcoma in an irradiated breast: a case description]. Actas Dermosifiliogr; 2005 Nov;96(9):602-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Angiosarcoma in an irradiated breast: a case description].
  • [Transliterated title] Angiosarcoma en mama irradiada: descripción de un caso.
  • Post-radiotherapy cutaneous angiosarcomas have been described in different locations, including the breast.
  • We present a case of cutaneous angiosarcoma of the breast, diagnosed 6 years after a carcinoma of the breast had been treated with radiation.
  • Considering the patient's symptoms, history and the changes observed via mammography, it was decided to completely excise the lesion followed by a simple mastectomy, with the diagnosis of angiosarcoma being confirmed.
  • The patient was later treated with paclitaxel, and the disease was apparently controlled.
  • Despite this fact, two years and one month later, the angiosarcoma recurred on the internal area of the mastectomy scar.
  • This complication usually appears 5-10 years after treatment with radiotherapy, so angiosarcoma should be ruled out if any angiomatous lesions later appear on skin that had been irradiated.
  • [MeSH-major] Breast Neoplasms / etiology. Breast Neoplasms / radiotherapy. Carcinoma, Ductal, Breast / radiotherapy. Hemangiosarcoma / etiology. Neoplasms, Radiation-Induced / etiology. Skin Neoplasms / etiology

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  • (PMID = 16476306.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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5. Ordoñez-Escalante KG, Mantilla-Morales A, Gallegos F: [Nasal cavity angiosarcoma: a case report and literature review]. Gac Med Mex; 2006 Mar-Apr;142(2):155-8
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  • [Title] [Nasal cavity angiosarcoma: a case report and literature review].
  • [Transliterated title] Angiosarcoma de cavidad nasal: informe de un caso y revisión de la literatura.
  • Sarcomas constitute 5% of all of head and neck neoplasms.
  • Angiosarcomas comprise 2% of all soft tissue tumors, 60% appear in skin and soft tissue, 50% in the head and neck and only 4% are present in the upper aerodigestive tract.
  • The histopathologic diagnosis was angiosarcoma.
  • Agiosarcomas of the upper aerodigestive tract have a better prognosis and long term survival free of disease than their soft tissue and skin counterparts.
  • [MeSH-major] Hemangiosarcoma / diagnosis. Nasal Cavity. Nose Neoplasms / diagnosis

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  • (PMID = 16711550.001).
  • [ISSN] 0016-3813
  • [Journal-full-title] Gaceta médica de México
  • [ISO-abbreviation] Gac Med Mex
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Mexico
  • [Number-of-references] 22
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6. Scow JS, Reynolds CA, Degnim AC, Petersen IA, Jakub JW, Boughey JC: Primary and secondary angiosarcoma of the breast: the Mayo Clinic experience. J Surg Oncol; 2010 Apr 1;101(5):401-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary and secondary angiosarcoma of the breast: the Mayo Clinic experience.
  • BACKGROUND AND OBJECTIVES: Angiosarcoma of the breast can be divided into primary and secondary.
  • The objective was to determine clinicopathologic factors associated with breast angiosarcoma and to compare primary versus secondary angiosarcoma.
  • METHODS: Breast angiosarcoma cases at Mayo Clinic from 1960 to 2008 were identified.
  • Characteristics of primary and secondary angiosarcoma were compared.
  • RESULTS: Twenty-seven cases of primary angiosarcoma and 14 cases of secondary angiosarcoma were identified.
  • The median age of primary angiosarcoma patients was lower than that of secondary angiosarcoma--43 years versus 73 years (P < 0.0001).
  • Primary angiosarcoma more frequently presented with a mass, whereas secondary angiosarcoma presented with a rash (P < 0.0001).
  • Median time from radiation to secondary angiosarcoma diagnosis was 6.8 years.
  • Median tumor size was 7.0 cm for primary angiosarcoma and 5.0 cm for secondary angiosarcoma (P = 0.7).
  • Tumors were high grade in 33% of primary angiosarcoma and 82% of secondary angiosarcoma (P = 0.02).
  • Five-year survival for primary and secondary angiosarcoma was 46% and 69%, respectively (P = 0.8).
  • CONCLUSION: Primary angiosarcoma occurs in younger patients than secondary and more frequently presents with a mass.
  • Mastectomy is the mainstay of treatment for breast angiosarcoma.
  • Breast angiosarcoma is a rare malignancy with poor long-term prognosis.
  • [MeSH-major] Breast Neoplasms / pathology. Hemangiosarcoma / pathology. Neoplasms, Second Primary / pathology

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  • [Copyright] (c) 2010 Wiley-Liss, Inc.
  • (PMID = 20119983.001).
  • [ISSN] 1096-9098
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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7. Verge J, Albiol J, Navas M, Martín C: [Primary angiosarcoma of the spleen with liver metastases. Case report and literature review]. Cir Esp; 2005 Jul;78(1):50-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Primary angiosarcoma of the spleen with liver metastases. Case report and literature review].
  • [Transliterated title] Angiosarcoma primario de bazo con metástasis hepáticas: presentación de un caso y revisión de la bibliografía.
  • Angiosarcomas of the spleen are infrequent tumors that often present with liver metastases.
  • Immunohistochemical markers can aid preoperative diagnosis since radiological and ultrasonographic images are fairly nonspecific.
  • [MeSH-major] Hemangiosarcoma / secondary. Hemangiosarcoma / surgery. Liver Neoplasms / secondary. Liver Neoplasms / surgery. Splenic Neoplasms / pathology. Splenic Neoplasms / surgery

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  • (PMID = 16420791.001).
  • [ISSN] 0009-739X
  • [Journal-full-title] Cirugía española
  • [ISO-abbreviation] Cir Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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8. Terada T: Fatal poorly differentiated angiosarcoma of the scalp. Int J Clin Exp Pathol; 2010;3(5):541-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fatal poorly differentiated angiosarcoma of the scalp.
  • Cutaneous angiosarcoma is a very rare but aggressive tumor.
  • Angiosarcoma of the scalp is very rare, and a review of the world literature revealed less than 60 cases.
  • Here, the author reports a case of poorly differentiated angiosarcoma of the scalp.
  • The pathological diagnosis was very difficult.
  • The biopsy showed proliferation of malignant spindle cells in the dermis.
  • Intracytoplasmic vacuoles were recognized in the malignant tumor cells in some places.
  • Immunohistochemically, the malignant spindle cells were positive for factor VIII-related antigen (F-VIII-RA), Ulex lectin, CD31, CD34, vimentin, p53 protein.
  • The intracytoplasmic vacuoles were strongly positive for F-VIII-RA, Ulex lectin, CD31, and CD34, The abortive vasoformative channels were moderately positive for these endothelial markers.
  • A pathologic diagnosis of angiosarcoma of the scalp was made.
  • [MeSH-major] Hemangiosarcoma / pathology. Scalp / pathology. Skin Neoplasms / pathology

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  • (PMID = 20606736.001).
  • [ISSN] 1936-2625
  • [Journal-full-title] International journal of clinical and experimental pathology
  • [ISO-abbreviation] Int J Clin Exp Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC2897108
  • [Keywords] NOTNLM ; CD31 / CD34 / Cutaneous angiosarcoma / Ulex lectin / for factor VIII-related antigen (F-VIII-RA) / p53 protein / scalp / vimentin
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9. Vertse G, Svastics E, Iványi A: [Postirradiation angiosarcoma of the breast]. Magy Seb; 2010 Aug;63(4):164-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Postirradiation angiosarcoma of the breast].
  • [Transliterated title] Besugárzás utáni angiosarcoma emloben.
  • Although secondary angiosarcomas (AS) are relatively rare neoplasms, they are increasingly recognized as the result of more breast conserving therapy (BCT) followed by radiotherapy.
  • The diagnosis of this very aggressive and rapidly spreading tumour is based on the immunohystochemical characteristics of the biopsy specimen.
  • [MeSH-major] Breast Neoplasms / radiotherapy. Hemangiosarcoma / diagnosis. Hemangiosarcoma / etiology. Mastectomy, Segmental. Neoplasms, Second Primary / diagnosis. Neoplasms, Second Primary / etiology

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  • (PMID = 20724241.001).
  • [ISSN] 0025-0295
  • [Journal-full-title] Magyar sebészet
  • [ISO-abbreviation] Magy Seb
  • [Language] hun
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Hungary
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers, Tumor
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10. Vogt T: [Angiosarcoma]. Hautarzt; 2008 Mar;59(3):237-48; quiz 249-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Angiosarcoma].
  • [Transliterated title] Angiosarkom.
  • Angiosarcomas are rare tumors accounting for 1-2% of all soft tissue sarcomas.
  • Angiosarcoma favors superficial soft tissues and skin (60%) with a clear predilection for the head and neck region.
  • The average age of the patients presenting with cutaneous angiosarcomas is around 70 years with a peak incidence in the 8th decade.
  • Secondary angiosarcoma after tissue-conserving radiation therapy for carcinoma of the breast represents an increasing problem, both the differentiation between atypical vascular lesions and true aggressive angiosarcoma and the therapy are challenging.
  • The prognosis for angiosarcoma patients is gloomy despite all therapeutic efforts.
  • [MeSH-major] Hemangiosarcoma / diagnosis. Hemangiosarcoma / therapy. Skin Neoplasms / diagnosis. Skin Neoplasms / therapy

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  • (PMID = 18273583.001).
  • [ISSN] 1432-1173
  • [Journal-full-title] Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
  • [ISO-abbreviation] Hautarzt
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 27
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11. Young RJ, Brown NJ, Reed MW, Hughes D, Woll PJ: Angiosarcoma. Lancet Oncol; 2010 Oct;11(10):983-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma.
  • Angiosarcomas are rare soft-tissue sarcomas of endothelial cell origin that have a poor prognosis.
  • They can arise anywhere in the body, most commonly presenting as cutaneous disease in elderly white men, involving the head and neck and particularly the scalp.
  • They can be caused by therapeutic radiation or chronic lymphoedema and hence secondary breast angiosarcomas are an important subgroup.
  • Recent work has sought to establish the molecular biology of angiosarcomas and identify specific targets for treatment.
  • Interest is now focused on trials of vascular-targeted drugs, which are showing promise in the control of angiosarcomas.
  • In this review we discuss angiosarcoma and its current management, with a focus on clinical trials investigating the treatment of advanced disease.
  • [MeSH-major] Hemangiosarcoma / therapy
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Male. Neoplasm Staging. Predictive Value of Tests. Risk Factors. Treatment Outcome

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  • [Copyright] Copyright © 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20537949.001).
  • [ISSN] 1474-5488
  • [Journal-full-title] The Lancet. Oncology
  • [ISO-abbreviation] Lancet Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
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12. Rodríguez-Bujaldón A, Vázquez-Bayo MC, Galán-Gutiérrez M, Jiménez-Puya R, Vélez García-Nieto A, Moreno-Giménez JC, Vidal-Jiménez A, Barroso-Casamitjana E: [Angiosarcoma in chronic lymphedema]. Actas Dermosifiliogr; 2006 Oct;97(8):525-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Angiosarcoma in chronic lymphedema].
  • [Transliterated title] Angiosarcoma sobre linfedema crónico.
  • Angiosarcoma that develops on a limb with chronic lymphedema is called Stewart-Treves syndrome.
  • The first corresponds to a typical syndrome of Stewart-Treves in an 83-year-old woman who was diagnosed of angiosarcoma in a chronic lymphedema territory secondary to mastectomy and radiotherapy due to breast cancer.
  • The second case is much rarer, since it is a case of diffuse angiosarcoma of the leg in a 42-year-old man with a history of lymphedema.
  • [MeSH-major] Hemangiosarcoma / etiology. Lymphedema / complications
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antibiotics, Antineoplastic / administration & dosage. Antibiotics, Antineoplastic / therapeutic use. Antineoplastic Agents, Alkylating / administration & dosage. Antineoplastic Agents, Alkylating / therapeutic use. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Arm. Doxorubicin / administration & dosage. Doxorubicin / therapeutic use. Female. Humans. Ifosfamide / administration & dosage. Ifosfamide / therapeutic use. Immunohistochemistry. Leg. Male. Skin / pathology. Skin Neoplasms / diagnosis. Skin Neoplasms / drug therapy. Skin Neoplasms / etiology. Skin Neoplasms / pathology. Skin Neoplasms / radiotherapy. Treatment Outcome

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  • (PMID = 17067532.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Antineoplastic Agents, Alkylating; 80168379AG / Doxorubicin; UM20QQM95Y / Ifosfamide
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13. Agulnik M, Okuno SH, Von Mehren M, Jovanovic B, Brockstein B, Benjamin RS, Evens AM: An open-label multicenter phase II study of bevacizumab for the treatment of angiosarcoma. J Clin Oncol; 2009 May 20;27(15_suppl):10522

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An open-label multicenter phase II study of bevacizumab for the treatment of angiosarcoma.
  • : 10522 Background: The limited therapeutic options and dismal prognosis for patients (pts) with angiosarcomas (AS) provide a strong rationale for the evaluation of new therapies.
  • METHODS: The study was a two-stage design in which patients with newly diagnosed or relapsed/refractory AS and epithelioid hemangioendotheliomas were treated with bevacizumab 15 mg/kg IV every 3 weeks.
  • Further studies with bevacizumab in combination with chemotherapy should be explored in this disease.

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  • (PMID = 27963911.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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14. Patnaik A, Chiorean EG, Tolcher A, Papadopoulos K, Beeram M, Kee D, Waddell M, Gilles E, Buchbinder A: EZN-2968, a novel hypoxia-inducible factor-1α (HIF-1α) messenger ribonucleic acid (mRNA) antagonist: Results of a phase I, pharmacokinetic (PK), dose-escalation study of daily administration in patients (pts) with advanced malignancies. J Clin Oncol; 2009 May 20;27(15_suppl):2564

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Tumor types included colorectal cancer (7 pts); renal cancer (4 pts); soft-tissue sarcoma (STS; 2 pts); angiosarcoma (1 pt); melanoma (1 pt); and breast, ovarian, pancreatic, and prostate cancers (1 pt each).
  • Stable disease was observed for 1 pt with angiosarcoma (28 wks) and 1 pt with renal cancer (12 wks).
  • Durable stable disease has been observed.

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  • (PMID = 27961885.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. Indelicato DJ, Keole SR, Shahlaee AH, Morris CG, Gibbs CP, Scarborough MT, Islam S, Marcus RB: Ewing tumors of the chest wall: Local control and long-term outcomes. J Clin Oncol; 2009 May 20;27(15_suppl):e21501

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • : e21501 Background: Primary sarcomas of the lungs and mediastinum are rare and few data are reported on treatment and results of therapy.
  • Pts characteristics: median age 41 (19-80 y), male/female 19/12; symptoms at diagnosis: dyspnoea (42%), chest and shoulder pain (39%), cough (35%), hemophtoae (13%), discomfort (10%).
  • 5 mediastinal tumours were located as follows: 2 in anterior part, 1 in posterior and 2 in the middle (sarcomas of the heart).
  • 26 lung sarcomas presented as a singular mass in 23 cases and as a metastatic disease in 3.
  • RESULTS: In 20/31 cases the tumour was immediately resected (3 mediastinal masses and 17 lung sarcomas).
  • The histology were: peripheral nerve tumour 7, leiomyosarcoma 4, MFH 2, fibrosarcoma 2, liposarcoma 1, angiosarcoma 2, undifferentiated sarcoma 1, solitary fibrous tumour 2, rhabdomyosarcoma 2, synovialsarcoma 2, pulmonary artery sarcoma 1, pleuropolmonary blastoma 1, malignant hemangiopericytoma 1, mixoid chondrosarcoma 1, ectopic osteosarcoma 1, aggressive fibromatosis 1.
  • Only 4 pts received neoadjuvant chemotherapy, 11 adjuvant CT, 5 exclusive CT + RT for inoperable disease.
  • Of these only 8 are alive (2 with disease).
  • Volume of disease, complete resection and grading are the dominant prognostic factors.
  • CONCLUSIONS: Primary sarcomas of the lungs and mediastinum have a very severe prognosis.

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  • (PMID = 27963390.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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16. Erbersdobler A, Simon R, Hellwinkel OJ, Bokemeyer C, Sauter G, Hu-Lowe D, Levin W, Gallo-Stampino C, Fiedler W: Analysis of expression of TGF-β1 receptor (ALK-1) in normal and tumor tissues by tissue microarrays. J Clin Oncol; 2009 May 20;27(15_suppl):e22044

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Activin-like kinase I (ALK-1) is a class I TGF- β1 receptor which is almost exclusively expressed on endothelial cells.
  • The highest ALK-1 expression rate was found in lung cancer (NSCLC 49%, SCLC 83%), neuroendocrine pancreas tumor (71%), colon cancer (50%), chondrosarcoma 50%, angiosarcoma 40% and NHL (44%).

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  • (PMID = 27963226.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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17. Pink D, Rahm J, Schoeler D, Schoenknecht TM, Reichardt P: Activity of paclitaxel in radiation induced and other secondary angiosarcomas. J Clin Oncol; 2009 May 20;27(15_suppl):10578

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Activity of paclitaxel in radiation induced and other secondary angiosarcomas.
  • : 10578 Background: Angiosarcomas (AS) represent 1-2% of adult soft tissue sarcomas and can arise anywhere in the body.
  • Paclitaxel has shown an exceptionally high activity of 75-89% in angiosarcomas of the face and scalp and to a lesser and less consitent degree of 15-58% in other disease locations.
  • We report on a retrospectice single center experience with chemotherapy in 17 patients (pts.) with secondary angiosarcomas (SAS).
  • 12 female patients suffered from angiosarcoma of the breast/thoracic wall following operation and radiation + chemotherapy of a primary breast cancer with an interval of a median of 6 years (range 2-15 years).
  • 3 pts. remain free of disease.
  • All 14 patients with recurrent/metastatic disease were treated with chemotherapy.
  • Responses were 8 PR with a median PFS of 6 months (range 3-23 months), and 1 SD (PFS 4 months) with a disease control rate of 75%.
  • CONCLUSIONS: Paclitaxel shows high activity in SAS, comparable to the results in face and scalp angiosarcomas and can be considered a standard treatment option.

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  • (PMID = 27963758.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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18. Galaychuk I: Breast sarcomas: Is now the time to change our mind? J Clin Oncol; 2009 May 20;27(15_suppl):e21524

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Breast sarcomas: Is now the time to change our mind?
  • : e21524 Background: Primary breast sarcoma usually was considered a rare malignant disease [Adem et al., 2004].
  • The aim of this study is to show the incidence of breast sarcoma in the region with female population of about 600,000.
  • METHODS: Retrospective comparative analysis of breast sarcoma and breast cancer incidence in female of Ternopil region for 2000 - 2008.
  • RESULTS: The total of 101 cases of breast sarcoma was diagnosed in female of 39 - 76 years of age.
  • Every year about 11 (6-18) primary breast sarcomas and 256 (233-279) patients with primary breast cancer were detected.
  • The incidence rate of breast sarcoma was 1.14 per 100,000 women in 2000, 2.94 (in 2001), 1.48 (2002), 0.99 (2003), 2.16 (2004), 1.67 (2005), 2.53 (2006), 2.03 (2007) and 1.87/100,000 in 2008.
  • Breast sarcoma consisted of 2.5% of the breast malignancies in 2000, 6.5% (in 2001), 3.3% (2002), 2.6% (2003), 5.4% (2004), 4.1% (2005), 5.9% (2006), 4.4% (2007) and 4.7% in 2008.
  • Pathohistologic examination revealed angiosarcoma in 92.1% of cases.
  • Thus, our findings are significantly different than data of other authors: f.e., the incidence of primary breast sarcoma is at 45 new cases per 10 million women [Confavreux et al., 2003], or 17 new cases per million women [Moore and Kinne, 1996], and breast sarcoma accounting for 0.0006% of breast malignancies which were diagnosed in 1910-2000 [Adem, 2004].
  • Taking into account all historical and recent data we can suggest beginning of biological changing in correlation between breast malignant tumors-carcinoma and sarcoma.
  • CONCLUSIONS: Our statistical finding shows that incidence of breast sarcoma is 1.87 (0.99-2.94) per of 100,000 female population, and now sarcomas consist of 4.4% (2.5-6.5%) of all malignant breast tumors.
  • Angiosarcoma is a most common (92.1%) morphological type of breast sarcomas.

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  • (PMID = 27963454.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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19. Comandone A, Boglione A, Pochettino P, Berno E, Inguì M, Papotti M, Borasio P, Maggi G, Brach Del Prever E, Gino G: Primary sarcomas of the lungs and mediastinum: Clinicopathological study and therapy results of Piedmontese Group for Sarcomas. J Clin Oncol; 2009 May 20;27(15_suppl):e21509

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary sarcomas of the lungs and mediastinum: Clinicopathological study and therapy results of Piedmontese Group for Sarcomas.
  • : e21509 Background: Primary sarcomas of the lungs and mediastinum are rare and few data are reported on treatment and results of therapy.
  • Pts characteristics: median age 41 (19-80 y), male/female 19/12; symptoms at diagnosis: dyspnoea (42%), chest and shoulder pain (39%), cough (35%), hemophtoae (13%), discomfort (10%).
  • 5 mediastinal tumours were located as follows: 2 in anterior part, 1 in posterior and 2 in the middle (sarcomas of the heart).
  • 26 lung sarcomas presented as a singular mass in 23 cases and as a metastatic disease in 3.
  • RESULTS: In 20/31 cases the tumour was immediately resected (3 mediastinal masses and 17 lung sarcomas).
  • The histology were: peripheral nerve tumour 7, leiomyosarcoma 4, MFH 2, fibrosarcoma 2, liposarcoma 1, angiosarcoma 2, undifferentiated sarcoma 1, solitary fibrous tumour 2, rhabdomyosarcoma 2, synovialsarcoma 2, pulmonary artery sarcoma 1, pleuropolmonary blastoma 1, malignant hemangiopericytoma 1, mixoid chondrosarcoma 1, ectopic osteosarcoma 1, aggressive fibromatosis 1.
  • Only 4 pts received neoadjuvant chemotherapy, 11 adjuvant CT, 5 exclusive CT + RT for inoperable disease.
  • Of these only 8 are alive (2 with disease).
  • Volume of disease, complete resection and grading are the dominant prognostic factors.
  • CONCLUSIONS: Primary sarcomas of the lungs and mediastinum have a very severe prognosis.

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  • (PMID = 27963441.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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20. Ramon Y Cajal T, Mazarico J, Lopez Pousa A, Quintana M, Sala N, Altabas M, Sebio A, Robert L, Alonso C, Barnadas A: Clinical features and outcome in primary breast sarcomas (BS): Analysis of a single-institution experience. J Clin Oncol; 2009 May 20;27(15_suppl):e21520

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical features and outcome in primary breast sarcomas (BS): Analysis of a single-institution experience.
  • Pathology: 17 cistosarcoma phylodes (CPh), 9 angiosarcoma, 2 extraesqueletical osteosarcoma, 2 fibrosarcomas, 1 liposarcoma, 1 leiomiosarcoma, 1 malignant fibrous histiocitoma (2.9%).

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  • (PMID = 27963450.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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21. Moreno-Vega A, Chavarría N, Rubio J, Villandiego I, Estepa R, Gordon M, Salvador J, Jimenez E: Primary breast sarcoma: Clinical and retrospective analysis of cases from Jerez General Hospital, Spain. J Clin Oncol; 2009 May 20;27(15_suppl):e21526

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary breast sarcoma: Clinical and retrospective analysis of cases from Jerez General Hospital, Spain.
  • : e21526 Background: Primary sarcomas of the breast (PBS) are a heterogeneous group of tumors from stromal breast, infrequent (0.1% of BC).
  • Diagnosis and treatment is unclear.
  • We analysed diseases outcomes (disease free survival, DFS) by histology high risk factors (tumor size, histology, and proliferation index).
  • RESULTS: Seven cases of PBS (1 male/6 female) were reviewed, from 790 BC diagnosed (0.8%): 2 angiosarcomas (AS), 1 malignant fibrous histiocytoma, 2 undifferentiated, one osteoclastic and other spindle-cell sarcoma.
  • CONCLUSIONS: PBS are rare and difficult diagnosis tumors.
  • There are few series published, without prospective studies to evaluate an adequate therapy, diagnosis and valuable prognostic factors.
  • Our incidence was high, but the independent pathology analysis confirmed all histopathological diagnosis.
  • This review included novel IHC and IRM images, considered necessary for diagnosis and personalized treatment.

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  • (PMID = 27963456.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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22. Biswas T, Tang P, Muhs A, Ling M: Angiosarcoma of the breast: a rare clinicopathological entity. Am J Clin Oncol; 2009 Dec;32(6):582-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma of the breast: a rare clinicopathological entity.
  • OBJECTIVES: Angiosarcoma is a rare subtype of sarcoma that usually arises after radiation therapy for primary breast cancer.
  • Primary sarcomas of the breast are rare entities and account for less than 1% of all malignant breast neoplasms.
  • We examine our institutional experience with angiosarcomas of the breast that were diagnosed and treated between 1996 and 2007.
  • METHODS: To conduct a retrospective review, all female patients with a diagnosis of angiosarcoma of the breast were identified from our pathology database.
  • RESULTS: A total of 8 patients were identified who had a histologically confirmed diagnosis of angiosarcoma of the breast.
  • Median age was 70.3 years at diagnosis (range, 35.6-85.7 years).
  • Seven (87%) patients had a history of prior radiation to the breast, whereas 1 (13%) had primary angiosarcoma.
  • CONCLUSIONS: Even though angiosarcomas are rare neoplasms, they are increasingly recognized as the result of more breast-conserving therapy.
  • High clinical suspicion and MRI may contribute to early diagnosis but a biopsy is always necessary to confirm it.
  • [MeSH-major] Breast Neoplasms / pathology. Hemangiosarcoma / pathology. Neoplasms, Radiation-Induced / pathology. Neoplasms, Second Primary / pathology

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  • (PMID = 19581792.001).
  • [ISSN] 1537-453X
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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23. Brenn T, Fletcher CD: Radiation-associated cutaneous atypical vascular lesions and angiosarcoma: clinicopathologic analysis of 42 cases. Am J Surg Pathol; 2005 Aug;29(8):983-96
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Radiation-associated cutaneous atypical vascular lesions and angiosarcoma: clinicopathologic analysis of 42 cases.
  • Cutaneous angiosarcoma is a rare but well-recognized complication after radiation therapy.
  • A total of 42 cases diagnosed as either radiation-associated cutaneous vascular lesions or angiosarcoma were retrieved from departmental and consultation files from 1995 to 2003.
  • Reasons for radiation included breast carcinoma (35 cases) and a variety of other lesions (mainly malignant disease).
  • Angiosarcomas presented as larger lesions (median, 7.5 cm) compared with AVLs (median, 0.5 cm).
  • The time interval from radiation was significantly shorter for the development of AVL (median, 3.5 years) compared with cutaneous angiosarcoma (median, 6 years).
  • Histologic evaluation revealed 26 lesions meeting criteria for angiosarcoma, ranging from morphologically low-grade to high-grade; 16 cases were classified as AVLs.
  • Some showed prominent hyperchromatic endothelial cells, while others were characterized by areas with a dissecting growth pattern within dermal collagen.
  • Endothelial multilayering was absent.
  • Clinical follow-up, available for 36 patients (range, 2-84 months; median, 17 months), revealed 4 patients who died of disease, 4 patients had systemic metastasis, and 12 patients with local recurrence.
  • All patients with systemic relapse had an initial diagnosis of angiosarcoma.
  • One patient with an AVL had a recurrence at the same site, 3 patients developed additional new lesions, and 1 patient developed multiple small papules on the chest wall, which progressed from an AVL to angiosarcoma.
  • This study outlines the morphologic spectrum of radiation-associated cutaneous AVLs.
  • [MeSH-major] Hemangiosarcoma / etiology. Hemangiosarcoma / pathology. Neoplasms, Radiation-Induced / pathology. Skin / blood supply. Skin / pathology. Skin Neoplasms / etiology. Skin Neoplasms / pathology

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  • (PMID = 16006792.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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24. Pfeiffer DF, Bode-Lesniewska B: Fine needle aspiration biopsy diagnosis of angiosarcoma after breast-conserving therapy for carcinoma supported by use of a cell block and immunohistochemistry. Acta Cytol; 2006 Sep-Oct;50(5):553-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fine needle aspiration biopsy diagnosis of angiosarcoma after breast-conserving therapy for carcinoma supported by use of a cell block and immunohistochemistry.
  • BACKGROUND: Angiosarcoma is a rare malignant soft tissue tumor occurring at various sites as either a primary or secondary event.
  • Primary angiosarcoma of the breast is an unusual tumor, counting for 1 in 1700-2,000 primary malignant tumors of this organ.
  • An increasing number of secondary angiosarcomas involving skin and breast.
  • CASE: Angiosarcoma arose 6 years after breast-conserving therapy for invasive carcinoma in a 69-year-old woman.
  • Fine needle aspiration of several small, reddish, intradermal nodules over the treated area revealed malignant cells with an endothelial immunophenotype in the cel block, yielding the diagnosis of angiosarcoma, subsequently confired in a mastectomy speciman.
  • CONCLUSION: Fine needle aspiration, supported by ancillary techniques, such as cell block and immunohistochemistry, allows the cytologic diagnosis of an angiosarcoma and differentiates it from a carcinoma recurrence.
  • [MeSH-major] Breast / pathology. Breast Neoplasms / diagnosis. Carcinoma, Ductal, Breast / diagnosis. Hemangiosarcoma / diagnosis. Neoplasms, Second Primary / diagnosis. Radiotherapy / adverse effects
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Biomarkers, Tumor / metabolism. Biopsy, Fine-Needle. Cell Nucleus / pathology. Diagnosis, Differential. Epithelial Cells / pathology. Female. Humans. Immunohistochemistry / methods. Neoplasm Recurrence, Local / diagnosis

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  • (PMID = 17017445.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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25. Le Corre Y, Avenel-Audran M, Croué A, Steff M, Verret JL: [Cutaneous angiosarcoma of the leg without lymphoedema]. Ann Dermatol Venereol; 2008 Jun-Jul;135(6-7):488-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Cutaneous angiosarcoma of the leg without lymphoedema].
  • [Transliterated title] Angiosarcome cutané de jambe sans lymphoedème associé.
  • BACKGROUND: Cutaneous angiosarcoma is a rare aggressive vascular neoplasm with a poor prognosis, seen chiefly in elderly subjects and usually on the scalp or face.
  • Histological examination showed vascular channels lined with atypical cells consistent with a diagnosis of angiosarcoma.
  • DISCUSSION: The leg is a rare site of cutaneous angiosarcoma.
  • [MeSH-major] Hemangiosarcoma. Leg. Skin Neoplasms

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  • (PMID = 18598799.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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26. Abraham JA, Hornicek FJ, Kaufman AM, Harmon DC, Springfield DS, Raskin KA, Mankin HJ, Kirsch DG, Rosenberg AE, Nielsen GP, Desphpande V, Suit HD, DeLaney TF, Yoon SS: Treatment and outcome of 82 patients with angiosarcoma. Ann Surg Oncol; 2007 Jun;14(6):1953-67
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Treatment and outcome of 82 patients with angiosarcoma.
  • BACKGROUND: Angiosarcomas are an uncommon type of malignancy that are generally thought to behave usually in a locally aggressive fashion; they often metastasize to distant sites.
  • METHODS: Patients with a diagnosis of angiosarcoma treated at our institution between 1980 and 2006 were analyzed for patient demographics, tumor characteristics, multimodality treatment, and outcomes.
  • RESULTS: A total of 82 patients were divided into those with primary and advanced disease.
  • Of 46 patients with primary disease, all patients underwent surgical resection, 67% received radiotherapy, and 27% received chemotherapy.
  • Five-year disease-specific survival was 60%, and negative prognostic factors included intermediate or high grade, and tumors arising in a radiated or lymphedema field.
  • Of 36 patients with advanced disease, 36% underwent a palliative operation, 78% received radiation, and 58% received chemotherapy.
  • CONCLUSIONS: Primary angiosarcomas treated with aggressive surgical resection and the addition of radiation for close margins or worrisome pathologic features can result in long-term survival in most patients.
  • Patients with advanced disease have a poor prognosis, but there can be dramatic responses to chemotherapy in a minority of patients.
  • [MeSH-major] Hemangiosarcoma / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Bone Neoplasms / pathology. Bone Neoplasms / surgery. Breast Neoplasms / pathology. Breast Neoplasms / surgery. Chemotherapy, Adjuvant. Disease-Free Survival. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoadjuvant Therapy. Neoplasm Staging. Neoplasms, Radiation-Induced / pathology. Neoplasms, Radiation-Induced / surgery. Palliative Care. Radiotherapy, Adjuvant. Retrospective Studies. Skin Neoplasms / pathology. Skin Neoplasms / surgery. Soft Tissue Neoplasms / pathology. Soft Tissue Neoplasms / surgery. Survival Rate. Treatment Outcome

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  • (PMID = 17356953.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / 5K12CA87723-03
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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27. Glazebrook KN, Magut MJ, Reynolds C: Angiosarcoma of the breast. AJR Am J Roentgenol; 2008 Feb;190(2):533-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma of the breast.
  • OBJECTIVE: This article describes the imaging findings, pathologic correlation, and clinical presentation of rare primary and secondary angiosarcomas of the breast.
  • CONCLUSION: With the increasing use of breast conservation therapy for breast cancer, reports of postirradiation angiosarcoma have increased.
  • Both primary and secondary angiosarcomas may present with bruiselike skin discoloration, which may delay the diagnosis.
  • [MeSH-major] Breast Neoplasms / diagnosis. Diagnostic Imaging / methods. Hemangiosarcoma / diagnosis. Image Enhancement / methods

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  • (PMID = 18212243.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 18
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28. Fodor J, Orosz Z, Szabó E, Sulyok Z, Polgár C, Zaka Z, Major T: Angiosarcoma after conservation treatment for breast carcinoma: our experience and a review of the literature. J Am Acad Dermatol; 2006 Mar;54(3):499-504
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma after conservation treatment for breast carcinoma: our experience and a review of the literature.
  • The development of angiosarcoma of the breast is a recognized complication of breast conservation therapy (BCT), but the evolution, prevalence, and outcome have not been accurately established.
  • We sought to evaluate and review the clinicopathologic, prognostic, and treatment attributes of angiosarcoma arising in the irradiated breast after BCT.
  • We conducted a retrospective chart and slide review of 8 patients seen between 1996 and 2004 with a diagnosis of secondary angiosarcoma.
  • The mean age of the patients at onset of the breast cancer and angiosarcoma was 65 and 72 years, respectively.
  • The mean latency period between the treatment of the breast cancer and the diagnosis of angiosarcoma was 75 months.
  • The estimated incidence of angiosarcoma after BCT was found to be 0.14 %.
  • BCT-associated angiosarcoma arises after a relatively brief interval, and breast edema-fibrosis can possibly contribute to its development.
  • As shown by a review of the literature, angiosarcomas are often resistant to surgery, chemotherapy, and radiotherapy, and targeted therapy against tumor biological properties may be a new approach to angiosarcoma treatment.
  • [MeSH-major] Breast Neoplasms / etiology. Breast Neoplasms / therapy. Hemangiosarcoma / etiology. Neoplasms, Second Primary / etiology

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  • (PMID = 16488303.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 41
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29. Markidou S, Karydas I, Papadopoulos S, Christodoulidou I, Skarpidi E, Maounis N: Fine needle aspiration cytology in primary breast angiosarcoma: a case report. Acta Cytol; 2010 Sep-Oct;54(5 Suppl):764-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fine needle aspiration cytology in primary breast angiosarcoma: a case report.
  • BACKGROUND: Angiosarcoma of the breast is an uncommon, aggressive, vascular tumor.
  • The cytomorphologic features of angiosarcomas have rarely been reported.
  • CASE: The present study describes a case of breast angiosarcoma initially diagnosed by fine needle aspiration cytology.
  • Angiosarcoma appeared in the left breast of a 58-year-old woman after 12 years of a mastectomy (without radiotherapy) of the contralateral breast for invasive ductal carcinoma.
  • Both cell types exhibited immunoreactivity for endothelial markers.
  • The diagnosis of angiosarcoma was confirmed by histopathology of the surgically excised tumor.
  • CONCLUSION: Angiosarcoma rarely occurs in the breast, and a definitive diagnosis is extremely difficult relying exclusively on cytologic features.
  • Predominance of epithelioid cells may suggest an epithelial tumor, especially in patients with a history of breast carcinoma, whereas predominance of spindle cells can be misinterpreted as phyllodes tumor or another type of sarcoma.
  • Cell block immunocytochemistry and tumor cell labeling with endothelial markers are necessary for accurate diagnosis.
  • [MeSH-major] Breast / pathology. Breast Neoplasms / pathology. Hemangiosarcoma / pathology
  • [MeSH-minor] Biopsy, Fine-Needle. Diagnosis, Differential. Epithelial Cells / pathology. Female. Humans. Immunohistochemistry. Mastectomy. Middle Aged

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  • (PMID = 21053536.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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30. Hindersin S, Schubert O, Cohnen M, Felsberg J, Schipper J, Hoffmann TK: [Angiosarcoma of the temporal bone]. Laryngorhinootologie; 2008 May;87(5):345-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Angiosarcoma of the temporal bone].
  • [Transliterated title] Angiosarkom des Os temporale.
  • Angiosarcoma of the temporal bone is an extremely rare malignant tumor, which originates from vascular endothelium.
  • After subtotal mastoidectomy histological examination revealed an angiosarcoma of the mastoid.
  • In this manuscript the morphology, imaging characteristics and current treatment options of angiosarcomas of the lateral skull base are reviewed and discussed.
  • [MeSH-major] Hemangiosarcoma / surgery. Skull Neoplasms / surgery. Temporal Bone / surgery
  • [MeSH-minor] Diagnosis, Differential. Disease Progression. Facial Paralysis / etiology. Fatal Outcome. Female. Hearing Loss, Sudden / etiology. Humans. Mastoid / pathology. Mastoid / surgery. Meninges / pathology. Middle Aged. Neck Dissection. Neoplasm Invasiveness. Neoplasm Staging

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  • (PMID = 18509895.001).
  • [ISSN] 0935-8943
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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31. Guode Z, Qi P, Hua G, Shangchen X, Hanbin W: Primary cerebellopontine angle angiosarcoma. J Clin Neurosci; 2008 Aug;15(8):942-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary cerebellopontine angle angiosarcoma.
  • Primary intracranial angiosarcomas are rare.
  • To our knowledge, no cerebellopontine (CP) angle angiosarcoma has been reported.
  • The preoperative diagnosis was neurogenic tumor with haemorrhage.
  • Histopathology and immunohistochemistry revealed an angiosarcoma.
  • This case report highlights that clinicians should be aware of the characteristics of angiosarcoma, and also stresses the need to include angiosarcoma in the differential diagnosis of rare lesions located in the CP angle.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Cerebellopontine Angle / pathology. Hemangiosarcoma / pathology

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  • (PMID = 18314334.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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32. Hirotsune N, Terada K, Meguro T, Nishino S, Asano T, Manabe T, Toi Y: [Superselective feeder embolization for hemorrhage from cutaneous angiosarcoma in scalp]. No Shinkei Geka; 2005 Oct;33(10):995-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Superselective feeder embolization for hemorrhage from cutaneous angiosarcoma in scalp].
  • The diagnosis of angiosarcoma was confirmed histologically.
  • The early diagnosis by neurosurgeon may lead to improved survival.
  • [MeSH-major] Embolization, Therapeutic / methods. Hemangiosarcoma / complications. Hemorrhage / therapy. Scalp. Skin Neoplasms / complications

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  • (PMID = 16223178.001).
  • [ISSN] 0301-2603
  • [Journal-full-title] No shinkei geka. Neurological surgery
  • [ISO-abbreviation] No Shinkei Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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33. Tsolakis I, Lampropoulos G, Zolota V, Papadoulas S, Christeas N: Aortic angiosarcoma with cutaneous metastases. Vascular; 2009 May-Jun;17(3):176-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Aortic angiosarcoma with cutaneous metastases.
  • Primary aortic tumors are rare and include a variety of histologic types, including aortic angiosarcomas, with less than 100 cases being reported since the first description of these tumors in 1873.
  • The diagnosis of aortic angiosarcoma is usually confirmed by postoperative histopathologic examination or postmortem study.
  • We present a case of primary aortic angiosarcoma presenting with intermittent claudication and radiologic findings of aortoiliac atherosclerotic disease treated initially with stenting; lower extremity embolic skin metastases developed during follow-up that prompted resection of the aortic bifurcation and restoration of the arterial continuity with a bypass.
  • [MeSH-major] Aortic Diseases / diagnostic imaging. Foot Diseases / etiology. Hemangiosarcoma / diagnostic imaging. Skin Neoplasms / secondary

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  • (PMID = 19476753.001).
  • [ISSN] 1708-5381
  • [Journal-full-title] Vascular
  • [ISO-abbreviation] Vascular
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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34. Di Tommaso L, Colombo G, Miceli S, Ferrari B, Santoro A, Poletti A, Roncalli M: [Angiosarcoma of the nasal cavity. Report of a case and review of the literature]. Pathologica; 2007 Jun;99(3):76-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Angiosarcoma of the nasal cavity. Report of a case and review of the literature].
  • [Transliterated title] Angiosarcoma della cavità nasale. Descrizione di un caso e revisione della letteratura.
  • We report an unusual case of primary angiosarcoma of the nasal cavity (AS-nc).
  • Clinical--monolateral epistaxis in a young person--, radiological--polypoid hemorrhagic tumor arising within the nasal cavity and expanding into paranasal sinuses--, pathological--a network of anastomosing channels and solid areas immunoreactive for CD31 and CD34--and prognostic features--patient alive and well 36 months after the original diagnosis--are superimposable to those of previously reported AS-nc, suggesting that this lesion should be considered as a peculiar variant of classical AS.
  • [MeSH-major] Hemangiosarcoma / pathology. Nasal Cavity. Nose Neoplasms / pathology

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  • (PMID = 17987727.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 10
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35. Bouhaouala MH, Charfi MR, Fajraoui N, Bouaziz N, Boukhris A, Kilani T: [Primary pulmonary angiosarcoma]. Rev Pneumol Clin; 2005 Apr;61(2):115-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Primary pulmonary angiosarcoma].
  • [Transliterated title] Angiosarcome pulmonaire primitif.
  • Pulmonary angiosarcoma is an uncommon vascular and usually secondary tumor.
  • Only a few primary cases of pulmonary angiosarcoma have been described.
  • We report a case of primary pulmonary angiosarcoma in an adult man who presented with hemoptysis.
  • Pulmonary angiosarcoma was diagnosed on histological and immuno-histochemical studies of the operative specimen.
  • This observation is added to the other rare cases published of primitive pulmonary angiosarcoma.
  • [MeSH-major] Hemangiosarcoma / diagnosis. Lung Neoplasms / diagnosis

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  • (PMID = 16012366.001).
  • [ISSN] 0761-8417
  • [Journal-full-title] Revue de pneumologie clinique
  • [ISO-abbreviation] Rev Pneumol Clin
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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36. Herrak L, Alaziz S, Benosmane A: [Primary pulmonary angiosarcoma]. Rev Mal Respir; 2007 Jan;24(1):73-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Primary pulmonary angiosarcoma].
  • [Transliterated title] Angiosarcome pulmonaire primitif.
  • INTRODUCTION: Primary pulmonary angiosarcoma (PPA) is a very rare tumour with a grave and short prognosis and whose primary site is difficult to confirm.
  • The diagnosis is essentially histological and immunohistochemical because there are no specific clinical or radiological signs.
  • The diagnosis was made by histological and immunohistochemical analysis of CT guided percutaneous biopsies.
  • [MeSH-major] Hemangiosarcoma / pathology. Lung Neoplasms / pathology

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  • (PMID = 17268369.001).
  • [ISSN] 0761-8425
  • [Journal-full-title] Revue des maladies respiratoires
  • [ISO-abbreviation] Rev Mal Respir
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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37. Lo Presti M, Mazzella C, Monfrecola A, Falleti J: Angiosarcoma mimicking rhinophyma. Dermatol Res Pract; 2010;2010:365173

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma mimicking rhinophyma.
  • During that time the patient underwent several dermatological consultations, and all produced the same diagnosis: rhinophyma.
  • Punch biopsy was performed, and histopathology and immunohistochemical studies were consistent with cutaneous angiosarcoma.
  • This is the report of a face angiosarcoma with an unusual and very deceptive clinical presentation.

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  • [Cites] Clin Exp Dermatol. 2009 Oct;34(7):e227-8 [19302586.001]
  • [Cites] Dermatol Surg. 2009 Apr;35(4):679-84 [19415795.001]
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  • (PMID = 20631905.001).
  • [ISSN] 1687-6113
  • [Journal-full-title] Dermatology research and practice
  • [ISO-abbreviation] Dermatol Res Pract
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC2902059
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38. Requena L, Santonja C, Stutz N, Kaddu S, Weenig RH, Kutzner H, Menzel T, Cerroni L: Pseudolymphomatous cutaneous angiosarcoma: a rare variant of cutaneous angiosarcoma readily mistaken for cutaneous lymphoma. Am J Dermatopathol; 2007 Aug;29(4):342-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pseudolymphomatous cutaneous angiosarcoma: a rare variant of cutaneous angiosarcoma readily mistaken for cutaneous lymphoma.
  • Cutaneous angiosarcoma is probably the most malignant neoplasm involving the skin.
  • Three clinical variants of cutaneous angiosarcoma are recognized, including angiosarcoma of the scalp and face of elderly patients, angiosarcoma associated with chronic lymphedema, and postirradiation angiosarcoma.
  • Histopathologically, these three variants of angiosarcoma show similar features, which consist of poorly circumscribed, irregularly dilated, and anastomosing vascular channels lined by prominent endothelial cells that dissect through the dermis.
  • Focally, neoplastic endothelial cells show large, hyperchromatic, and pleomorphic nuclei, protruding within vascular lumina and creating small papillations.
  • In rare instances, cutaneous angiosarcomas may exhibit prominent inflammatory infiltrate, and the neoplasm may be mistaken for an inflammatory process, both from clinical and histopathologic points of view.
  • We describe four examples of cutaneous angiosarcomas with dense lymphocytic infiltrates involving the neoplasm.
  • The neoplastic endothelial cells expressed immunoreactivity for the CD31, CD34, podoplanin, Prox-1, Lyve-1, and D2-40.
  • We discuss the possible relationship between neoplastic endothelial lymphatic cells and reactive lymphocytes.
  • Cutaneous angiosarcoma with prominent lymphocytic infiltrate may be readily mistaken for cutaneous follicle center cell lymphoma or cutaneous pseudolymphoma.
  • [MeSH-major] Hemangiosarcoma / diagnosis. Lymphoma / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged. Breast Neoplasms / diagnosis. Diagnosis, Differential. Endothelial Cells / pathology. Endothelium, Vascular / pathology. Facial Neoplasms / diagnosis. Female. Humans. Lymphocytes / pathology. Lymphoma, Follicular / diagnosis. Male. Middle Aged. Neovascularization, Pathologic / pathology. Pseudolymphoma / diagnosis. Scalp / pathology. Skin Diseases / diagnosis

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  • (PMID = 17667166.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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39. Centella T, Oliva E, García Andrade I, Lamas MJ, Epeldegui A: [A patient with cardiac angiosarcoma who survived for four years. Case report and literature review]. Rev Esp Cardiol; 2005 Mar;58(3):310-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A patient with cardiac angiosarcoma who survived for four years. Case report and literature review].
  • [Transliterated title] Angiosarcoma cardíaco. Cuatro años de supervivencia. Revisión a propósito de un caso.
  • We describe a 57-year-old woman with a diagnosis of primary cardiac angiosarcoma.
  • She underwent emergency surgery with a preoperative diagnosis of atrial myxoma, and pathological analysis confirmed the diagnosis of cardiac angiosarcoma.
  • [MeSH-major] Heart Neoplasms. Hemangiosarcoma

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  • (PMID = 15766456.001).
  • [ISSN] 0300-8932
  • [Journal-full-title] Revista española de cardiología
  • [ISO-abbreviation] Rev Esp Cardiol
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 5
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40. Mittal S, Goswami C, Kanoria N, Bhattacharya A: Post-irradiation angiosarcoma of bone. J Cancer Res Ther; 2007 Apr-Jun;3(2):96-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Post-irradiation angiosarcoma of bone.
  • Radiation therapy is extensively used for treatment of malignancies, but angiosarcomas occurring in an irradiated area are uncommon.
  • We report a rare case of high-grade epithelioid angiosarcoma of upper end of right humerus in a 67-year-old male occurring ten years following irradiation for giant cell tumor of the same anatomical site.
  • After initial histopathological diagnostic dilemma the final report was given as post-radiation angiosarcoma.
  • Disease recurred at the end of one-year follow-up period where upon he underwent wide resection with prosthesis replacement.
  • [MeSH-major] Bone Neoplasms / diagnosis. Hemangiosarcoma / diagnosis. Humerus. Neoplasms, Radiation-Induced / diagnosis
  • [MeSH-minor] Aged. Humans. Male. Neoplasm Recurrence, Local / diagnosis. Treatment Outcome

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  • (PMID = 17998731.001).
  • [ISSN] 1998-4138
  • [Journal-full-title] Journal of cancer research and therapeutics
  • [ISO-abbreviation] J Cancer Res Ther
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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41. Astudillo L, Cron C, Gomez-Brouchet A, Couret B, Arlet-Suau E: [Angiosarcoma of the aorta]. Rev Med Interne; 2007 Oct;28(10):718-20

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Angiosarcoma of the aorta].
  • [Transliterated title] Angiosarcome épithélioïde de l'aorte.
  • Histopathology revealed an epithelioid angiosarcoma of the aorta.

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  • (PMID = 17587469.001).
  • [ISSN] 0248-8663
  • [Journal-full-title] La Revue de medecine interne
  • [ISO-abbreviation] Rev Med Interne
  • [Language] FRE
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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42. Mizrachi IB, Trobe JD, Deeb MG, Ramsburgh SR, Williams DM, Gebarski SS: Multiple brain infarcts and Balint syndrome in aortic arch angiosarcoma. J Neuroophthalmol; 2006 Jun;26(2):107-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multiple brain infarcts and Balint syndrome in aortic arch angiosarcoma.
  • The surgical specimen revealed angiosarcoma.
  • Of the few reported angiosarcomas involving the aorta, most have been located in the abdominal segment.
  • This is only the second reported case of aortic arch sarcoma presenting with stroke.
  • [MeSH-major] Agnosia / etiology. Aorta, Thoracic. Brain Infarction / etiology. Hemangiosarcoma / complications. Ocular Motility Disorders / etiology. Vascular Neoplasms / complications
  • [MeSH-minor] Diagnosis, Differential. Fatal Outcome. Female. Humans. Magnetic Resonance Imaging. Middle Aged. Syndrome. Tomography, X-Ray Computed

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  • (PMID = 16845310.001).
  • [ISSN] 1070-8022
  • [Journal-full-title] Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society
  • [ISO-abbreviation] J Neuroophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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43. Rozen WM, Mann GB: Angiosarcoma arising in an unirradiated breast with subsequent pituitary metastasis. Clin Breast Cancer; 2007 Oct;7(10):811-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma arising in an unirradiated breast with subsequent pituitary metastasis.
  • Angiosarcoma of the breast is a rare condition with known risk factors.
  • The Stewart-Treves syndrome describes angiosarcoma of the arm or breast in the setting of adjuvant radiation therapy (RT) after breast conservation surgery.
  • Angiosarcoma of the breast, in the absence of RT, is rarer still.
  • We present a unique case of angiosarcoma of the breast, diagnosed 6 years after conservative surgery for carcinoma of the breast when no adjuvant RT was given.
  • Chronic postoperative lymphoedema in the breast delayed the investigation of skin changes, with an eventual diagnosis of angiosarcoma.
  • An isolated pituitary metastasis 9 months from the diagnosis, the first such reported case, adds to the complexity of the case.
  • The diagnosis and management of angiosarcoma of the breast is discussed.
  • Angiosarcoma is a rare occurrence after breast conservative surgery.
  • Postoperative lymphoedema can impede early diagnosis.
  • The disease can display unique metastatic potential.
  • [MeSH-major] Breast Neoplasms / pathology. Hemangiosarcoma / secondary. Neoplasms, Second Primary / pathology. Pituitary Neoplasms / secondary

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  • (PMID = 18021485.001).
  • [ISSN] 1526-8209
  • [Journal-full-title] Clinical breast cancer
  • [ISO-abbreviation] Clin. Breast Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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44. Moore A, Hendon A, Hester M, Samayoa L: Secondary angiosarcoma of the breast: can imaging findings aid in the diagnosis? Breast J; 2008 May-Jun;14(3):293-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Secondary angiosarcoma of the breast: can imaging findings aid in the diagnosis?
  • Secondary angiosarcomas, although rare, are aggressive tumors that can develop in breast tissue that has undergone prior radiation therapy.
  • We present three cases of secondary angiosarcoma of the breast in the setting of prior breast irradiation.
  • These imaging findings may enable the radiologist to suggest this diagnosis, even when the clinical presentation is more benign.
  • [MeSH-major] Breast Neoplasms / diagnosis. Hemangiosarcoma / diagnosis. Neoplasm Recurrence, Local / diagnosis. Neoplasms, Radiation-Induced / diagnosis

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  • (PMID = 18476885.001).
  • [ISSN] 1524-4741
  • [Journal-full-title] The breast journal
  • [ISO-abbreviation] Breast J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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45. Ortiz Mendoza CM: [Recurrent breast haematoma after fine needle aspiration biopsy of angiosarcoma]. Ginecol Obstet Mex; 2007 Mar;75(3):164-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Recurrent breast haematoma after fine needle aspiration biopsy of angiosarcoma].
  • [Transliterated title] Hematoma mamario recidivante posterior a la biopsia por aspiración con aguja delgada en un angiosarcoma.
  • It is reported a rare complication after a fine needle aspiration biopsy of a breast angiosarcoma.
  • A fine needle aspiration biopsy was carried out for diagnosis, but only blood was report.
  • Four months later a recurrence presented, and a new excision was carried out with a resulting moderately differentiated angiosarcoma, then a simple mastectomy was performed for definitive treatment.
  • A recurrent haematoma after a fine needle aspiration biopsy of a breast tumor mandates to rule out an angiosarcoma.
  • [MeSH-major] Biopsy, Fine-Needle / adverse effects. Breast / injuries. Breast Neoplasms / pathology. Hemangiosarcoma / pathology. Hematoma / etiology

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  • (PMID = 17547091.001).
  • [ISSN] 0300-9041
  • [Journal-full-title] Ginecología y obstetricia de México
  • [ISO-abbreviation] Ginecol Obstet Mex
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Mexico
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46. Ozcelik C, Onat S, Yaldiz M, Ozcelik Z: Primary epithelioid angiosarcoma of the lung presenting as pulmonary hemorrhage. Asian Cardiovasc Thorac Ann; 2006 Feb;14(1):69-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary epithelioid angiosarcoma of the lung presenting as pulmonary hemorrhage.
  • Pulmonary angiosarcomas are usually secondary tumors, and only a few primary cases have been reported.
  • We report a unique case of epithelioid angiosarcoma presenting as a solitary mass in the right upper lobe with pulmonary hemorrhage.
  • Because of its epithelioid histology, this tumor may resemble a carcinoma or a variety of vascular lesions with epithelioid endothelial cells.
  • Therefore, the diagnosis of epithelioid angiosarcoma should be based on immunohistochemical staining.
  • [MeSH-major] Epithelioid Cells / pathology. Hemangiosarcoma / diagnosis. Hemorrhage / etiology. Lung Diseases / etiology. Lung Neoplasms / diagnosis
  • [MeSH-minor] Chest Pain / etiology. Cough / etiology. Diagnosis, Differential. Fatal Outcome. Hemoptysis / etiology. Humans. Immunohistochemistry. Lung / diagnostic imaging. Lung / pathology. Lung / surgery. Male. Middle Aged. Rare Diseases. Tomography, X-Ray Computed

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  • (PMID = 16432125.001).
  • [ISSN] 1816-5370
  • [Journal-full-title] Asian cardiovascular & thoracic annals
  • [ISO-abbreviation] Asian Cardiovasc Thorac Ann
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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47. Bhattacharya P, Singh P, Bahal A, Gulati D, Tevatia MS, Mehta A, Muttagikar MP: Angiosarcoma of pericardium: a report of two cases. Indian J Pathol Microbiol; 2007 Oct;50(4):777-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma of pericardium: a report of two cases.
  • Angiosarcomas are uncommon malignant neoplasms characterized by rapidly proliferating extensively infiltrating anaplastic cells derived from blood vessels and lining irregular, blood-filled spaces.
  • Here we present two cases of pericardial angiosarcoma, one of them showing widespread dissemination, which caused considerable diagnostic dilemma and the diagnosis could only be established very late in their course of disease.
  • [MeSH-major] Hemangiosarcoma / diagnosis. Hemangiosarcoma / pathology. Pericardium / pathology
  • [MeSH-minor] Adult. Fatal Outcome. Humans. Male. Middle Aged. Neoplasm Metastasis / diagnosis. Neoplasm Metastasis / pathology

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  • (PMID = 18306551.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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48. Plotnik AN, Schweder P, Tsui A, Kavar B: Splenic angiosarcoma metastasis to the brain. J Clin Neurosci; 2008 Aug;15(8):927-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Splenic angiosarcoma metastasis to the brain.
  • Angiosarcoma is a rare primary non-haematolymphoid malignant neoplasm of the spleen.
  • This neoplastic process has a poor prognosis, with disease usually widespread by the time of presentation.
  • In the literature there has been only six case reports of cerebral metastasis from splenic angiosarcomas.
  • We report a 61-year-old woman who presented with a right occipital metastasis of a splenic angiosarcoma, 5 years after initial diagnosis, treated by stereotactic occipital craniotomy and resection of metastasis.
  • [MeSH-major] Brain Neoplasms / secondary. Hemangiosarcoma / pathology. Splenic Neoplasms / pathology

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  • (PMID = 18411053.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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49. Carnero López B, Fernández Pérez I, Carrasco Alvarez JA, Lázaro Quintela ME, López Jato C, Jorge Fernández M, Gentil González M, Vázquez Tuñas L, Castellanos Díez J: Renal primary angiosarcoma. Clin Transl Oncol; 2007 Dec;9(12):806-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Renal primary angiosarcoma.
  • Angiosarcomas account for 2% of all soft tissue sarcomas and of them, primary renal angiosarcomas represent 1%.
  • We report the second case to be described in a middle-aged female, with pulmonary metastases at diagnosis, and fatal outcome despite surgery and chemotherapy.
  • [MeSH-major] Hemangiosarcoma / pathology. Kidney Neoplasms / pathology

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  • (PMID = 18158986.001).
  • [ISSN] 1699-048X
  • [Journal-full-title] Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
  • [ISO-abbreviation] Clin Transl Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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50. Amonkar GP, Deshpande JR: Cardiac angiosarcoma. Cardiovasc Pathol; 2006 Jan-Feb;15(1):57-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cardiac angiosarcoma.
  • Myxoma is the most common primary cardiac tumor, while angiosarcoma is the commonest primary malignant tumor.
  • A malignant mass was seen arising in the right atrium, with pericardial effusion and multiple metastases in the lung.
  • A complete autopsy was performed and a diagnosis of cardiac angiosarcoma was confirmed on histology and immunohistochemistry.
  • [MeSH-major] Heart Neoplasms / pathology. Hemangiosarcoma / secondary

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  • (PMID = 16414459.001).
  • [ISSN] 1054-8807
  • [Journal-full-title] Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology
  • [ISO-abbreviation] Cardiovasc. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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51. Mendenhall WM, Mendenhall CM, Werning JW, Reith JD, Mendenhall NP: Cutaneous angiosarcoma. Am J Clin Oncol; 2006 Oct;29(5):524-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cutaneous angiosarcoma.
  • OBJECTIVE: To discuss the treatment and outcomes for cutaneous angiosarcoma.
  • RESULTS: Cutaneous angiosarcoma is a rare, aggressive malignancy with a poor prognosis.
  • A subset of patients presents with multifocal disease and/or positive regional nodes.
  • Although the optimal treatment is surgery followed by wide-field radiotherapy (RT), the disease is frequently so extensive at diagnosis that it is not completely resectable.
  • CONCLUSION: Cutaneous angiosarcoma is a rare, aggressive malignancy that is optimally treated with resection and wide-field postoperative RT.
  • [MeSH-major] Hemangiosarcoma / therapy. Skin Neoplasms / therapy

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  • (PMID = 17023791.001).
  • [ISSN] 1537-453X
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 27
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52. Abbott R, Palmieri C: Angiosarcoma of the breast following surgery and radiotherapy for breast cancer. Nat Clin Pract Oncol; 2008 Dec;5(12):727-36
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma of the breast following surgery and radiotherapy for breast cancer.
  • Breast angiosarcoma following surgery and radiotherapy for breast cancer is a rare but important clinical entity.
  • This article reviews all published cases and includes data on incidence, etiology, presentation, diagnosis, management and prognosis.
  • Breast angiosarcoma remains challenging clinically, radiologically and histologically, and thus a high index of suspicion is required in susceptible patients.
  • There have been recent reports of patients with metastatic disease responding to taxane chemotherapy, and there might be a future role for targeted agents given the expression of c-KIT in a subset of angiosarcomas.
  • [MeSH-major] Breast Neoplasms / epidemiology. Hemangiosarcoma / epidemiology. Neoplasm Recurrence, Local / epidemiology. Neoplasms, Radiation-Induced

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  • (PMID = 18936792.001).
  • [ISSN] 1743-4262
  • [Journal-full-title] Nature clinical practice. Oncology
  • [ISO-abbreviation] Nat Clin Pract Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 90
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53. Suzuki H, Komatsu A, Fujioka Y, Yamashiro K, Takeda H, Hamada T: Angiosarcoma-like metastatic carcinoma of the liver. Pathol Res Pract; 2010 Jul 15;206(7):484-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma-like metastatic carcinoma of the liver.
  • Two cases of metastatic carcinoma strikingly simulating angiosarcoma in the liver are described.
  • Both cases had an angiosarcoma-like appearance macroscopically and microscopically.
  • Immunohistochemically, the tumor cells of both cases were negative for CD31, CD34, and Factor VIII-related antigen and positive for several types of cytokeratin, suggesting that they were not angiosarcomas but carcinomas.
  • Angiosarcoma is the most common sarcoma arising in the liver.
  • Thus, metastatic carcinoma, which resembles angiosarcoma, might be mistaken for angiosarcoma.
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. Female. Hemangiosarcoma / pathology. Humans. Immunohistochemistry. Middle Aged

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  • [Copyright] Copyright 2009 Elsevier GmbH. All rights reserved.
  • (PMID = 20097483.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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54. Fujita T, Taira N, Ogasawara Y, Omori M, Doihara H: Bilateral angiosarcoma of the breast detected by magnetic resonance imaging during pregnancy. Int J Clin Oncol; 2009 Dec;14(6):560-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bilateral angiosarcoma of the breast detected by magnetic resonance imaging during pregnancy.
  • Angiosarcoma of the breast is an aggressive malignancy of endothelial origin with a tendency for local regional recurrence.
  • The involvement of angiosarcomas in the bilateral breasts has rarely been documented.
  • Of note, due to its rarity and typically unclear clinical findings upon examination, the diagnosis of a contralateral lesion can be difficult, particularly in women during pregnancy.
  • Here we present a rare case of bilateral angiosarcoma of the breast during pregnancy.
  • Diagnosed as angiosarcoma preoperatively, excision of the bilateral tumors was performed.
  • Histological findings of the removed bilateral tumors were compatible with high-grade angiosarcoma of the breast.
  • [MeSH-major] Breast Neoplasms / diagnosis. Hemangiosarcoma / diagnosis. Magnetic Resonance Imaging. Mammary Glands, Human / pathology. Pregnancy Complications, Neoplastic / diagnosis

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  • (PMID = 19967497.001).
  • [ISSN] 1437-7772
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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55. Ishigami N, Horiba K: Primary cardiac angiosarcoma resection combined with right coronary artery bypass grafting. Jpn J Thorac Cardiovasc Surg; 2005 Nov;53(11):624-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary cardiac angiosarcoma resection combined with right coronary artery bypass grafting.
  • Diagnosis of a primary malignant tumor in the right atrium without distant metastasis was made by echocardiography, computed tomography and coronary angiography.
  • Final diagnosis was of angiosarcoma by pathological examination.
  • [MeSH-major] Coronary Artery Bypass / methods. Heart Neoplasms / surgery. Hemangiosarcoma / surgery

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  • (PMID = 16363724.001).
  • [ISSN] 1344-4964
  • [Journal-full-title] The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai zasshi
  • [ISO-abbreviation] Jpn. J. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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56. Chen YB, Guo LC, Yang L, Feng W, Zhang XQ, Ling CH, Ji C, Huang JA: Angiosarcoma of the lung: 2 cases report and literature reviewed. Lung Cancer; 2010 Dec;70(3):352-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma of the lung: 2 cases report and literature reviewed.
  • Angiosarcoma is a kind of malignant tumors derived from vascular endothelial cell.
  • Pulmonary angiosarcomas are usually secondary tumors, and primary cases are less than 20 so far.
  • Here we presented two cases of angiosarcoma involved the lung, and we only confirmed case 2 as a primary pulmonary angiosarcoma.
  • The clinical characteristics, diagnosis, treatment options and prognosis of pulmonary angiosarcoma were reviewed in this article too.
  • [MeSH-major] Brain Neoplasms / diagnosis. Hemangiosarcoma / diagnosis. Liver Neoplasms / diagnosis. Lung Neoplasms / diagnosis

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  • [Copyright] Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 20952087.001).
  • [ISSN] 1872-8332
  • [Journal-full-title] Lung cancer (Amsterdam, Netherlands)
  • [ISO-abbreviation] Lung Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Antigens, CD34
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57. Karamlou T, Li MK, Williamson WK, Heller L, Wiest JW: Angiosarcoma of the thoracoabdominal aorta presenting with systemic hypertension, anemia, and visceral ischemia. Ann Vasc Surg; 2008 May-Jun;22(3):459-64
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma of the thoracoabdominal aorta presenting with systemic hypertension, anemia, and visceral ischemia.
  • Aortic angiosarcomas, one of the three major types of primary aortic tumors, are exceedingly rare, with only 25 cases reported in the literature.
  • Peripheral thromboembolic complications are the most frequently described presenting feature, and therefore, these tumors can be mistaken for aortoiliac occlusive disease.
  • We describe a rare case of an extensive thoracoabdominal angiosarcoma that manifested with hypertension, profound anemia, and visceral ischemia in a young woman.
  • [MeSH-major] Anemia / etiology. Aorta, Thoracic / pathology. Hemangiosarcoma / diagnosis. Hypertension / etiology. Ischemia / etiology. Vascular Neoplasms / diagnosis. Viscera / blood supply

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  • (PMID = 18367372.001).
  • [ISSN] 1615-5947
  • [Journal-full-title] Annals of vascular surgery
  • [ISO-abbreviation] Ann Vasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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58. Kardum-Skelin I, Jelić-Puskarić B, Pazur M, Vidić-Paulisić I, Jakić-Razumović J, Separović V: A case report of breast angiosarcoma. Coll Antropol; 2010 Jun;34(2):645-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case report of breast angiosarcoma.
  • Angiosarcoma is a rare disease of the breast with the reported incidence of only 0.04% of all breast malignancies.
  • The etiology of angiosarcoma remains unknown.
  • We present a patient with angiosarcoma which developed 12 years of the diagnosis of breast carcinoma and 8 years of the operative procedure and radiotherapy for disease recurrence.
  • A small angiomatous lesion of a few mm in size, cytologically suspect of vascular tumor (hemangioma or hemangiopericytoma) and histopathologically verified to be an atypical vascular lesion, was detected two years before breast enlargement and cytologic and histologic diagnosis of angiosarcoma.
  • The patient died 15 months of the diagnosis of angiosarcoma, after two tumor recurrences and intrathoracic cavity invasion.
  • [MeSH-major] Breast Neoplasms / pathology. Hemangiosarcoma / pathology

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  • (PMID = 20698145.001).
  • [ISSN] 0350-6134
  • [Journal-full-title] Collegium antropologicum
  • [ISO-abbreviation] Coll Antropol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
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59. Ito T, Tsutsumi T, Ohno K, Takizawa T, Kitamura K: Intracranial angiosarcoma arising from a schwannoma. J Laryngol Otol; 2007 Jan;121(1):68-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intracranial angiosarcoma arising from a schwannoma.
  • Angiosarcomas rarely arise from schwannomas, but we describe here a case of angiosarcoma that arose from a remnant of a benign vestibular schwannoma that had been removed 10 years earlier.
  • The patient died nine months after diagnosis, primarily as result of an abscess in the cerebellum and base of the skull.
  • The histological diagnosis was confirmed by the immunohistochemical findings of positivity for CD34 antigen and S-100 protein in the resected tumour.A review of the literature revealed four other cases of angiosarcoma with schwannoma, all of which arose from an extracranial nerve.
  • The present case is the first report of an angiosarcoma with schwannoma arising from an intracranial locus.
  • [MeSH-major] Brain Neoplasms / pathology. Hemangiosarcoma / pathology. Neoplasms, Second Primary / pathology. Neurilemmoma / pathology

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  • (PMID = 16995966.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 11
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60. Pohar-Marinsek Z, Lamovec J: Angiosarcoma in FNA smears: diagnostic accuracy, morphology, immunocytochemistry and differential diagnoses. Cytopathology; 2010 Oct;21(5):311-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma in FNA smears: diagnostic accuracy, morphology, immunocytochemistry and differential diagnoses.
  • OBJECTIVE: The aim of our study was to analyse the diagnostic accuracy in recognizing angiosarcoma from fine needle aspiration (FNA) samples and to determine morphological features of angiosarcoma in cytology.
  • METHODS: FNA samples from 18 histologically confirmed angiosarcomas obtained between 1985 and 2009 were included in the study.
  • RESULTS: There were 13 primary angiosarcomas and five recurrent tumours; nine tumours were epithelioid.
  • Twelve tumours were cytologically diagnosed as malignant, three as suspicious and three were judged unsatisfactory.
  • Cytomorphology did not correlate well with histology in mixed and spindle cell types of angiosarcomas.
  • Immunocytochemistry was applied in seven cases, specific vascular marker CD31 only twice at the time of diagnosis and three times retrospectively.
  • CONCLUSIONS: Angiosarcomas are difficult to recognize on FNA smears when they lack the typical dual, spindle and epithelioid cell population and when they occur in internal organs where carcinomas are more common.
  • [MeSH-major] Hemangiosarcoma / pathology
  • [MeSH-minor] Adult. Aged. Antigens, CD31. Biomarkers, Tumor / metabolism. Biopsy, Fine-Needle. Cytodiagnosis. Diagnosis, Differential. Diagnostic Errors. Epithelioid Cells / metabolism. Epithelioid Cells / pathology. Female. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Recurrence, Local. Reproducibility of Results

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  • (PMID = 20105214.001).
  • [ISSN] 1365-2303
  • [Journal-full-title] Cytopathology : official journal of the British Society for Clinical Cytology
  • [ISO-abbreviation] Cytopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Biomarkers, Tumor
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61. Böge G, Gallix B, Gresillon C, Khau Van Kien A, Veerapen R, Quéré I: [Primary angiosarcoma of the aorta]. Vasa; 2007 Feb;36(1):33-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Primary angiosarcoma of the aorta].
  • [Transliterated title] Primäres Angiosarkom der Aorta.
  • Primary angiosarcoma of the aorta is a rare disease.
  • The prognosis is poor, resulting of embolic complications and early metastatic disease, with a median survival of nine months.
  • Diagnosis is difficult and often made post-mortem.
  • We report the case of a 68-year-old woman referred for a thrombosis of the superior mesenteric artery, occurring a few weeks after resection of an angiosarcoma of the small intestine, disclosing a primary angiosarcoma of the aortic wall with metastatic disease.
  • [MeSH-major] Aorta, Thoracic. Aortic Diseases / diagnosis. Hemangiosarcoma / diagnosis. Mesenteric Artery, Superior. Mesenteric Vascular Occlusion / etiology. Thrombosis / etiology. Vascular Neoplasms / diagnosis
  • [MeSH-minor] Aged. Aortography. Combined Modality Therapy. Diagnosis, Differential. Female. Humans. Ileal Neoplasms / diagnosis. Ileal Neoplasms / pathology. Ileal Neoplasms / secondary. Ileal Neoplasms / therapy. Image Processing, Computer-Assisted. Imaging, Three-Dimensional. Jejunal Neoplasms / diagnosis. Jejunal Neoplasms / pathology. Jejunal Neoplasms / secondary. Jejunal Neoplasms / therapy. Palliative Care. Tomography, X-Ray Computed

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  • (PMID = 17323296.001).
  • [ISSN] 0301-1526
  • [Journal-full-title] VASA. Zeitschrift für Gefässkrankheiten
  • [ISO-abbreviation] VASA
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 34
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62. Elawar A, Dandurand M, Jumez N, Delfour C, Branchereau P, Stoebner P, Meunier L: [Cutaneous metastasis revealing epithelioid angiosarcoma of the abdominal aorta]. Ann Dermatol Venereol; 2010 Feb;137(2):111-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Cutaneous metastasis revealing epithelioid angiosarcoma of the abdominal aorta].
  • [Transliterated title] Métastases cutanées révélatrices d'un angiosarcome épithélioïde de l'aorte abdominale.
  • BACKGROUND: Epithelioid angiosarcomas (EAS) of the aorta are a rare form of tumour usually diagnosed by histopathological analysis of the aorta.
  • The course of the disease involved distal ischaemia.
  • Histological examination of a nodule showed proliferation of malignant cells with expression of vimentin, CD 31, cytokeratins AE1/AE3 and cytokeratin 7.
  • These findings suggested a diagnosis of EAS of the aorta with skin and osseous metastasis and vascular emboli.
  • Skin metastasis causes papular eruption, nodules and peripheral vascular disease.
  • Our case report emphasizes four key points: the diagnostic value of an association of localized malignant skin tumours, extensive livedo, ipsilateral distal ischaemia, deterioration of the general condition and intense pain; the diagnostic value of endothelial markers, especially CD31, and potentially misleading co-expression of cytokeratin markers; in selected cases, additional imaging, such as PET scans, performed in our case for the first time prior to surgery of the aorta, may be helpful for the diagnosis of such neoplastic lesions of the aortic wall.
  • [MeSH-major] Aorta, Abdominal / pathology. Hemangiosarcoma / pathology. Hemangiosarcoma / secondary. Skin Neoplasms / secondary. Vascular Neoplasms / pathology

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  • [Copyright] Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20171432.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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63. Lin CF, DeFrias D, Lin X: Epithelioid angiosarcoma: a neoplasm with potential diagnostic challenges. Diagn Cytopathol; 2010 Feb;38(2):154-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epithelioid angiosarcoma: a neoplasm with potential diagnostic challenges.
  • Epithelioid angiosarcomas are extremely rare tumors associated with poor prognosis and early metastases.
  • Further, immunohistochemical evaluation demonstrated positive CD31 and Factor VIII staining and established the final diagnosis of epithelioid angiosarcoma.
  • This case is reported to illustrate the importance of considering the diagnosis of epithelioid angiosarcoma when encountering an "epithelioid" neoplasm particularly with unusual immunoreactivity for CK7 and CD30.
  • [MeSH-major] Biomarkers, Tumor / analysis. Hemangioendothelioma, Epithelioid / secondary. Pelvic Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Diagnosis, Differential. Humans. Immunohistochemistry. Liver Neoplasms / secondary. Male. Young Adult

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  • (PMID = 19813270.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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64. Hanasono MM, Osborne MP, Dielubanza EJ, Peters SB, Gayle LB: Radiation-induced angiosarcoma after mastectomy and TRAM flap breast reconstruction. Ann Plast Surg; 2005 Feb;54(2):211-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Radiation-induced angiosarcoma after mastectomy and TRAM flap breast reconstruction.
  • Radiation-induced angiosarcoma of the breast is being reported with increasing frequency as a result of the increased use of radiation therapy in conjunction with breast conservation surgery.
  • The authors present a case of angiosarcoma occurring in a patient 6 years after undergoing mastectomy for invasive duct carcinoma with immediate transverse rectus abdominis musculocutaneous flap reconstruction followed by postoperative radiation therapy.
  • The diagnosis of angiosarcoma was made by skin biopsy performed by the patient's reconstructive surgeon on routine follow-up examination.
  • This is the first reported case of postradiation angiosarcoma occurring in a postmastectomy breast reconstructed with autogenous tissue and it is unusual in that the cancer invaded the musculocutaneous flap.
  • Diagnosis and management recommendations for radiation-induced angiosarcoma are discussed.
  • [MeSH-major] Breast Neoplasms / surgery. Carcinoma, Ductal, Breast / surgery. Hemangiosarcoma / etiology. Mastectomy, Modified Radical. Neoplasms, Radiation-Induced / surgery

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  • (PMID = 15655476.001).
  • [ISSN] 0148-7043
  • [Journal-full-title] Annals of plastic surgery
  • [ISO-abbreviation] Ann Plast Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ki-67 Antigen
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65. Delacruz V, Jorda M, Gomez-Fernandez C, Benedetto P, Ganjei P: Fine-needle aspiration diagnosis of angiosarcoma of the spleen: a case report and review of the literature. Arch Pathol Lab Med; 2005 Aug;129(8):1054-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fine-needle aspiration diagnosis of angiosarcoma of the spleen: a case report and review of the literature.
  • Primary angiosarcoma of the spleen is a very rare neoplasm with a poor prognosis.
  • The definitive diagnosis is usually based on the histologic evaluation of the splenectomy specimen.
  • We describe a case of angiosarcoma diagnosed by fine-needle aspiration cytology prior to splenectomy.
  • A malignant endothelial neoplasm was diagnosed by fine-needle aspiration cytology using immunocytochemistry, and a splenectomy confirmed the presence of angiosarcoma.
  • To our knowledge, this is the first well-documented and confirmed case of primary angiosarcoma of the spleen diagnosed by fine-needle aspiration cytology.
  • [MeSH-major] Biopsy, Fine-Needle. Hemangiosarcoma / secondary. Splenic Neoplasms / pathology

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  • (PMID = 16048401.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Biomarkers, Tumor; 9001-27-8 / Factor VIII
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66. Gherardi G, Rossi S, Perrone S, Scanni A: Angiosarcoma after breast-conserving therapy: fine-needle aspiration biopsy, immunocytochemistry, and clinicopathologic correlates. Cancer; 2005 Jun 25;105(3):145-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma after breast-conserving therapy: fine-needle aspiration biopsy, immunocytochemistry, and clinicopathologic correlates.
  • BACKGROUND: Angiosarcoma that arises after breast-conserving therapy can present clinically as a cutaneous and/or subcutaneous breast lump, which is misinterpreted easily as a recurrence of carcinoma.
  • To the authors' knowledge, the role of fine-needle aspiration (FNA) cytology in the early diagnosis of this life-threatening complication of breast carcinoma therapy has not been established fully.
  • METHODS: The authors studied three new patients with this type of secondary angiosarcoma diagnosed by FNA biopsy and immunocytochemistry, reviewed the literature on the topic, and examined relevant differential diagnostic issues.
  • Immunostaining of smears, however, provided conclusive evidence of the endothelial differentiation of tumor cells, and an FNA diagnosis of angiosarcoma was rendered in all patients.
  • The histopathology of all surgically excised tumors confirmed the diagnosis of high-grade angiosarcoma.
  • CONCLUSIONS: Based on the authors' experience, the FNA cytologic appearance of angiosarcoma that presented as a breast skin nodule in a breast carcinoma survivor easily could have been misinterpreted as carcinoma.
  • A correct diagnosis of this tumor relies on the proper evaluation of clinical findings and, as also shown by a review of the literature, requires immunocytochemical evidence of endothelial differentiation.
  • [MeSH-major] Biopsy, Fine-Needle. Breast Neoplasms / pathology. Breast Neoplasms / surgery. Hemangiosarcoma / secondary. Mastectomy, Segmental / adverse effects. Skin Neoplasms / secondary

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  • (PMID = 15844179.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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67. Mignogna C, Simonetti S, Galloro G, Magno L, De Cecio R, Insabato L: Duodenal epithelioid angiosarcoma: immunohistochemical and clinical findings. A case report. Tumori; 2007 Nov-Dec;93(6):619-21
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  • [Title] Duodenal epithelioid angiosarcoma: immunohistochemical and clinical findings. A case report.
  • Angiosarcomas are uncommon malignant tumors of vascular endothelium that represent less than 1% of all sarcomas.
  • The epithelioid variant of angiosarcomas is exceptionally rare, and the gastrointestinal tract is rarely involved.
  • Angiosarcomas mainly involve skin and soft tissue and rarely occur in breast, liver, bone, and spleen.
  • A duodenal reddish polypoid lesion was found, which on microscopic examination turned out to be an epithelioid angiosarcoma.
  • The immunohistochemical features of the lesion supported this diagnosis.
  • The patient died eight months after the diagnosis.
  • Epithelioid angiosarcoma is an aggressive variant of angiosarcoma and must be considered in the differential diagnosis of gastrointestinal tumors.
  • [MeSH-major] Duodenal Neoplasms / pathology. Hemangioendothelioma, Epithelioid / pathology. Hemangiosarcoma / pathology

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  • (PMID = 18338501.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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68. Erpolat OP, Icli F, Dogan OV, Gokaslan G, Akmansu M, Erekul S, Yucel E: Primary cardiac angiosarcoma: a case report. Tumori; 2008 Nov-Dec;94(6):892-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary cardiac angiosarcoma: a case report.
  • Cardiac angiosarcomas are malignant tumors that almost always have a poor prognosis.
  • We describe a 29-year-old man with primary cardiac angiosarcoma with multiple site metastases.
  • We discuss the diagnosis and treatment of cardiac angiosarcoma in the light of a case report.
  • [MeSH-major] Heart Neoplasms / pathology. Hemangiosarcoma / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male. Prognosis. Tomography, X-Ray Computed

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  • (PMID = 19267115.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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69. Takenaka M, Tanaka M, Isobe M, Yamaguchi R, Kojiro M, Shirouzu K: Angiosarcoma of the breast with silicone granuloma: a case report. Kurume Med J; 2009;56(1-2):33-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma of the breast with silicone granuloma: a case report.
  • Angiosarcoma of the breast is a rare non-epithelial tumor and that accounts for less than 0.1% of primary malignancies of the breast.
  • The disease has a relatively higher occurrence among young people, and its prognosis (3-year-survival of only 38%) is extremely poor compared to breast cancer.
  • The histological diagnosis was angiosarcoma of the breast with silicone granuloma.
  • [MeSH-major] Breast Implantation / adverse effects. Breast Neoplasms / etiology. Hemangiosarcoma / etiology. Silicone Gels / adverse effects

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  • (PMID = 20103999.001).
  • [ISSN] 1881-2090
  • [Journal-full-title] The Kurume medical journal
  • [ISO-abbreviation] Kurume Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Silicone Gels
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70. Ishibashi N, Mitachi Y, Sugawara S, Shinozaki S, Miura M, Fukuju T, Katahira Y, Koyama K, Fujikawa N, Kato T, Murakami K: [A case of cardiac angiosarcoma successfully treated with docetaxel]. Gan To Kagaku Ryoho; 2007 Nov;34(11):1849-52
Hazardous Substances Data Bank. DOCETAXEL .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of cardiac angiosarcoma successfully treated with docetaxel].
  • We report a case of angiosarcoma of the right atrium presenting superior vena cava syndrome.
  • The pathological diagnosis was angiosarcoma.
  • The patient agreed to chemotherapy with docetaxel, which is known to be often effective against angiosarcoma of the scalp or face.
  • He had long-term survival 31 months after the diagnosis.
  • An effective treatment for cardiac angiosarcoma has not yet been established.
  • Chemotherapy with docetaxel should be considered in the treatment of patients with cardiac angiosarcoma.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Heart Neoplasms / drug therapy. Hemangiosarcoma / drug therapy. Taxoids / therapeutic use

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  • (PMID = 18030022.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Taxoids; 15H5577CQD / docetaxel
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76. Souza OE, Etchebehere RM, Lima MA, Monti PR: Primary renal angiosarcoma. Int Braz J Urol; 2006 Jul-Aug;32(4):448-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary renal angiosarcoma.
  • Primary renal Angiosarcoma is a rare neoplasm and only 24 cases have been reported in specialized literature.
  • We describe a case of primary renal angiosarcoma in a patient presenting with hematuria, palpable abdominal mass, left flank pain and anemia.
  • Diagnosis was given in a morphologic base and proven by an immunohistochemical study.
  • Primary renal angiosarcoma should be included among differential diagnosis of retroperitoneal hematoma and hemorrhagic renal tumors.
  • [MeSH-major] Hemangiosarcoma / diagnosis. Kidney Neoplasms / diagnosis

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  • (PMID = 16953913.001).
  • [ISSN] 1677-5538
  • [Journal-full-title] International braz j urol : official journal of the Brazilian Society of Urology
  • [ISO-abbreviation] Int Braz J Urol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Brazil
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77. Vasanawala MS, Wang Y, Quon A, Gambhir SS: F-18 fluorodeoxyglucose PET/CT as an imaging tool for staging and restaging cutaneous angiosarcoma of the scalp. Clin Nucl Med; 2006 Sep;31(9):534-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] F-18 fluorodeoxyglucose PET/CT as an imaging tool for staging and restaging cutaneous angiosarcoma of the scalp.
  • Cutaneous angiosarcoma of the scalp is a rare highly aggressive malignant tumor that typically afflicts elderly patients and commonly presents with extensive local spread and distant metastasis.
  • It differs from other soft tissue sarcomas in that the size of the lesion at presentation instead of tumor grade is the important prognostic factor.
  • Local extent is critical in surgical planning, especially in the head and face, and is difficult to determine accurately with clinical examination and morphologic imaging tools.
  • We report the case of a 70-year-old man diagnosed with multifocal angiosarcoma of the scalp.
  • PET/CT imaging with F-18 2-fluoro-2-deoxyglucose (F-18 FDG) not only showed avid FDG uptake by an angiosarcoma (SUVmax = 10.7), but also simultaneously showed local extension of multifocal lesions with periosteal involvement and excluded metastatic abdominal nodal disease.
  • Evaluation of more cases of this subset of soft tissue sarcoma with FDG PET/CT may suggest a possible role in not only staging angiosarcomas to determine the extent of local as well as distant disease, but also to potentially help determine response to therapy and early recognition of local or distant recurrence.
  • [MeSH-major] Fluorodeoxyglucose F18. Hemangiosarcoma / diagnosis. Hemangiosarcoma / radionuclide imaging. Neoplasm Staging / methods. Positron-Emission Tomography / methods. Radiopharmaceuticals. Scalp / pathology. Skin Neoplasms / diagnosis. Skin Neoplasms / radionuclide imaging. Tomography, X-Ray Computed / methods

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  • (PMID = 16921276.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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78. Olsun A, Duzyol C, Gur AK, Kaplan M, Tosun R: Right atrial angiosarcoma: a case report. Heart Surg Forum; 2007;10(3):E219-21

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Right atrial angiosarcoma: a case report.
  • The pathological diagnosis based on the samples obtained during the operation was angiosarcoma.
  • We believe that advancements in radiotherapy and chemotherapy regimes combined with surgery (radical, if possible) for the treatment of cardiac angiosarcomas may provide better survival and quality-of-life results.
  • [MeSH-major] Heart Neoplasms / diagnosis. Heart Neoplasms / surgery. Hemangiosarcoma / diagnosis. Hemangiosarcoma / surgery

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  • (PMID = 17599895.001).
  • [ISSN] 1522-6662
  • [Journal-full-title] The heart surgery forum
  • [ISO-abbreviation] Heart Surg Forum
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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79. Policarpio-Nicolas ML, Nicolas MM, Keh P, Laskin WB: Postradiation angiosarcoma of the small intestine: a case report and review of literature. Ann Diagn Pathol; 2006 Oct;10(5):301-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Postradiation angiosarcoma of the small intestine: a case report and review of literature.
  • Postradiation angiosarcoma is typically a high-grade sarcoma that presents mainly in the skin and superficial tissues.
  • Postradiation angiosarcoma arising in the small intestine is rare with only 11 cases documented in the English-language literature.
  • Herein, we report a postradiation angiosarcoma of the small intestine 9 years after radiotherapy for uterine cervical adenocarcinoma.
  • The diagnosis of angiosarcoma was confirmed immunohistochemically by tumor cell expression of CD31, CD34, and factor VIII-related antigen.
  • The diagnosis of PRA should be entertained for any poorly differentiated neoplasm arising in a previously irradiated site.
  • The correct diagnosis of PRA depends upon histomorphologic identification of vascular differentiation, coupled with immunohistochemical expression of endothelial-related markers.
  • [MeSH-major] Hemangiosarcoma / etiology. Intestinal Neoplasms / etiology. Intestine, Small. Neoplasms, Radiation-Induced / diagnosis

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  • (PMID = 16979525.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Antigens, CD34; 9001-27-8 / Factor VIII
  • [Number-of-references] 17
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80. Hsu CW, Lin CH, Yang TL, Chang HT: Splenic inflammatory pseudotumor mimicking angiosarcoma. World J Gastroenterol; 2008 Nov 7;14(41):6421-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Splenic inflammatory pseudotumor mimicking angiosarcoma.
  • A case of a 32-year-old man with a splenic inflammatory pseudotumor (IPT) mimicking splenic angiosarcoma is described.
  • The tumor was highly suspected of being splenic angiosarcoma based on radiological findings preoperatively.
  • Splenic IPT and angiosarcoma are rare and often pose diagnostic difficulties because the clinical and radiological findings are obscure.
  • [MeSH-major] Granuloma, Plasma Cell / pathology. Hemangiosarcoma / pathology. Splenic Diseases / pathology. Splenic Neoplasms / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male. Splenectomy. Tomography, X-Ray Computed. Treatment Outcome. Ultrasonography

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  • (PMID = 19009664.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2766130
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81. Hosokawa Y, Kodani E, Kusama Y, Kamiya M, Yoshikawa M, Hirasawa Y, Nakagomi A, Atarashi H, Maeda S, Mizuno K: Cardiac angiosarcoma diagnosed by transvenous endomyocardial biopsy with the aid of transesophageal echocardiography and intra-procedural consultation. Int Heart J; 2010;51(5):367-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cardiac angiosarcoma diagnosed by transvenous endomyocardial biopsy with the aid of transesophageal echocardiography and intra-procedural consultation.
  • Transthoracic echocardiography (TTE) and contrast-enhanced computed tomography (CT) scans demonstrated a large mass in the right atrium and multiple liver tumors thought to be due to spread of the disease.
  • In order to confirm the histological diagnosis, we attempted transvenous endomyocardial tumor biopsy under fluoroscopic guidance.
  • These findings indicated a definite diagnosis of angiosarcoma.
  • [MeSH-major] Biopsy / methods. Heart Neoplasms / diagnosis. Heart Neoplasms / pathology. Hemangiosarcoma / pathology. Ultrasonography, Interventional / methods

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  • (PMID = 20966612.001).
  • [ISSN] 1349-3299
  • [Journal-full-title] International heart journal
  • [ISO-abbreviation] Int Heart J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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82. Granier G, Lemoine MC, Mares P, Pignodel C, Marty-Double C: [Primary angiosarcoma of the male breast]. Ann Pathol; 2005 Jun;25(3):235-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Primary angiosarcoma of the male breast].
  • [Transliterated title] Angiosarcome primitif du sein chez l'homme.
  • We report an exceptional case of primary breast angiosarcoma in a 58-year-old man.
  • Diagnosis should be established as early as possible because the 10-year overall survival rate is 80% for low grade tumors and only 20% for high grade tumors.
  • [MeSH-major] Breast Neoplasms / pathology. Hemangiosarcoma / pathology

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  • (PMID = 16230950.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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83. Hamid KS, Rodriguez JA, Lairmore TC: Primary splenic angiosarcoma. JSLS; 2010 Jul-Sep;14(3):431-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary splenic angiosarcoma.
  • Primary splenic angiosarcoma is a rare, aggressive malignant neoplasm arising from splenic vascular endothelium.
  • Laparoscopic splenectomy was performed, and a primary splenic angiosarcoma was discovered.
  • After 2 rounds of chemotherapy, a CT scan showed progressive disease with metastasis to the liver and lung.
  • She is currently alive with evidence of disease at 9 months but without further progression.
  • Primary splenic angiosarcoma is almost universally fatal despite treatment.
  • The best chance for survival is early diagnosis and prompt splenectomy prior to splenic rupture.

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  • (PMID = 21333203.001).
  • [ISSN] 1086-8089
  • [Journal-full-title] JSLS : Journal of the Society of Laparoendoscopic Surgeons
  • [ISO-abbreviation] JSLS
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3041046
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84. Nascimento AF, Raut CP, Fletcher CD: Primary angiosarcoma of the breast: clinicopathologic analysis of 49 cases, suggesting that grade is not prognostic. Am J Surg Pathol; 2008 Dec;32(12):1896-904
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary angiosarcoma of the breast: clinicopathologic analysis of 49 cases, suggesting that grade is not prognostic.
  • Mammary angiosarcoma is a rare neoplasm, accounting for about 0.05% of all primary malignancies of the breast.
  • It is currently believed that histologic grading of mammary angiosarcomas plays an important role in prognostication.
  • Forty-nine cases of primary angiosarcoma of the breast were retrieved from our files.
  • Ten patients (24.4%) showed evidence of local recurrence within 11 to 60 months (median 36) after diagnosis.
  • Time interval between diagnosis and metastasis ranged from 2 to 144 months (median 34).
  • Eighteen patients (44%) so far have died of disease and 1 died of presumably disseminated breast carcinoma.
  • Five patients (12.2%) are alive with disease and 15 patients (36.6%) are alive with no evidence of disease.
  • Statistical analysis evaluating correlation between tumor grade and size, and rate of local recurrence, metastasis, and death owing to disease showed no significant difference among tumors of different grades.
  • In conclusion, mammary angiosarcoma is a rare disease that affects relatively younger patients.
  • This tumor seems to have an overall similar clinical course as other types of angiosarcoma arising in skin or soft tissue; it carries a moderate risk of local recurrence, and a high risk of metastasis and death.
  • In this large series, there is no correlation between histologic grade and patient outcome, more in line with angiosarcomas at other sites.
  • [MeSH-major] Breast Neoplasms / pathology. Hemangiosarcoma / pathology
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Aged. Disease-Free Survival. Female. Humans. Middle Aged. Prognosis

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  • (PMID = 18813119.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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85. Sparsa A, Liozon E, Wechsler J, Soria P, Delage-Core M, Loustaud V, Bedane C, Bonnetblanc JM, Vidal E: Aortic angiosarcoma clinically mimicking polyarteritis nodosa. Scand J Rheumatol; 2006 May-Jun;35(3):237-40
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  • [Title] Aortic angiosarcoma clinically mimicking polyarteritis nodosa.
  • We report two patients in whom angiosarcoma of the aorta (ASA) with distal emboli and skin metastases was initially clinically misdiagnosed as polyarteritis nodosa (PAN).
  • [MeSH-major] Aortic Diseases / diagnosis. Hemangiosarcoma / diagnosis. Polyarteritis Nodosa / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Male. Middle Aged. Neoplastic Cells, Circulating. Skin Neoplasms / secondary

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  • (PMID = 16766373.001).
  • [ISSN] 0300-9742
  • [Journal-full-title] Scandinavian journal of rheumatology
  • [ISO-abbreviation] Scand. J. Rheumatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Norway
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86. Ryu DY, Hwang SY, Lee DW, Kim TO, Park DY, Kim GH, Heo J, Kang DH, Song GA, Cho M: [A case of primary angiosarcoma of small intestine presenting as recurrent gastrointestinal bleeding]. Korean J Gastroenterol; 2005 Nov;46(5):404-8
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  • [Title] [A case of primary angiosarcoma of small intestine presenting as recurrent gastrointestinal bleeding].
  • Angiosarcoma is a rare malignant tumor which occurs frequently in the skin and soft subcutis.
  • Moreover, primary gastrointestinal angiosarcomas are very rare.
  • The diagnosis is often made at an advanced stage.
  • We report a case of primary angiosarcoma of the small intestine presenting as recurrent gastrointestinal bleeding.
  • The ileal mass was diagnosed as angiosarcoma on immunohistochemical stain.
  • He received 3 cycles of chemotherapy, but died 5 months after the diagnosis.
  • [MeSH-major] Gastrointestinal Hemorrhage / etiology. Hemangiosarcoma / diagnosis. Intestinal Neoplasms / diagnosis. Intestine, Small

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  • (PMID = 16301855.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Korea (South)
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87. Lund L, Amre R: Epithelioid angiosarcoma involving the lungs. Arch Pathol Lab Med; 2005 Jan;129(1):e7-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epithelioid angiosarcoma involving the lungs.
  • Although cytologic features and pattern of metastatic spread can guide in narrowing the list of possible primary neoplasms, immunohistochemistry remains pivotal in determining the phenotype of metastatic disease.
  • Electron microscopy of formalin-fixed tissue revealed multiple Weibel-Palade bodies and pinocytosis, supporting the diagnosis of epithelioid angiosarcoma.
  • Doppler studies performed after pathologic diagnosis was rendered demonstrated 2 discrete hypoechoic masses within the medial aspect of the left proximal calf musculature, suggestive of solid soft tissue neoplasm-a possible source of pulmonary metastatic disease.
  • [MeSH-major] Epithelioid Cells / pathology. Hemangiosarcoma / secondary. Lung Neoplasms / secondary. Neoplasms, Unknown Primary / diagnosis

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  • (PMID = 15628928.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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88. Qureshi YA, Strauss DC, Thway K, Fisher C, Thomas JM: Angiosarcoma developing in a non-functioning arteriovenous fistula post-renal transplant. J Surg Oncol; 2010 May 1;101(6):520-3
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  • [Title] Angiosarcoma developing in a non-functioning arteriovenous fistula post-renal transplant.
  • BACKGROUND: Angiosarcomas comprise less than 1% of all sarcomas, arising from endothelial cells of blood or lymph vessels.
  • Chronic immunosuppression increases the risk of many malignancies and an association between the development of angiosarcoma with an immunosuppressed state is established.
  • A few cases have been reported of angiosarcomas arising in the post-renal transplant patient.
  • Specifically, there have been six cases of an angiosarcoma arising in arteriovenous (AV) fistulae in this patient population.
  • We describe a further case and review the relevant literature with specific emphasis on a possible mechanism for the development of angiosarcoma in the post-transplant patient.
  • CASE PRESENTATION: We report the case of a 48-year-old male who developed an angiosarcoma in a ligated native AV fistula.
  • CONCLUSION: Angiosarcomas are extremely rare tumours but should be considered as a differential diagnosis for an evolving mass near the site of an AV fistula.
  • Diagnosis relies on an index of suspicion and obtaining a definitive histological diagnosis.
  • [MeSH-major] Arteriovenous Shunt, Surgical / adverse effects. Hemangiosarcoma / etiology. Kidney Transplantation. Vascular Neoplasms / etiology

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  • [Copyright] (c) 2010 Wiley-Liss, Inc.
  • (PMID = 20191610.001).
  • [ISSN] 1096-9098
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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89. Mano MS, Fraser G, Kerr J, Gray M, Evans V, Kazmi A, Canney P: Radiation-induced angiosarcoma of the breast shows major response to docetaxel after failure of anthracycline-based chemotherapy. Breast; 2006 Feb;15(1):117-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Radiation-induced angiosarcoma of the breast shows major response to docetaxel after failure of anthracycline-based chemotherapy.
  • We report on the case of a patient with a diagnosis of an uncommon breast tumour, namely a radiation-induced angiosarcoma, which was primarily refractory to anthracycline-based chemotherapy, but highly sensitive to docetaxel.
  • Although the sarcomas in general tend to be relatively refractory to taxanes, there is some evidence that the angiosarcomas may be sensitive to these agents.
  • [MeSH-major] Antineoplastic Agents, Phytogenic / therapeutic use. Breast Neoplasms / drug therapy. Breast Neoplasms / etiology. Hemangiosarcoma / drug therapy. Hemangiosarcoma / etiology. Neoplasms, Radiation-Induced / drug therapy. Taxoids / therapeutic use

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  • (PMID = 16473744.001).
  • [ISSN] 0960-9776
  • [Journal-full-title] Breast (Edinburgh, Scotland)
  • [ISO-abbreviation] Breast
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; 0 / Taxoids; 15H5577CQD / docetaxel; 3Z8479ZZ5X / Epirubicin; 8N3DW7272P / Cyclophosphamide; U3P01618RT / Fluorouracil
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90. Kodali D, Seetharaman K: Primary cardiac angiosarcoma. Sarcoma; 2006;2006:39130

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary cardiac angiosarcoma.
  • Primary cardiac sarcoma is a rare clinical entity, with an incidence of 0.0001% in collected autopsy series.
  • Early heart transplantation and novel radiation therapy approaches may offer a survival benefit in nonmetastatic tumors, but up to 80% of the patients present with systemic metastasis at diagnosis.
  • Liposomal doxorubicin (PLD) has been shown to be useful in the treatment of soft tissue sarcomas, and our case supports its use in cardiac angiosarcoma.

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  • [Cites] Cancer. 1999 Nov 15;86(10):2034-7 [10570428.001]
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  • (PMID = 17251657.001).
  • [ISSN] 1357-714X
  • [Journal-full-title] Sarcoma
  • [ISO-abbreviation] Sarcoma
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC1698140
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91. Fujii Y, Koibuchi-Yamaoka H, Taniguchi N, Yasuda Y, Nagai H: Metastasis from a primary angiosarcoma of the scalp to the colon: sonographic and CT findings. J Clin Ultrasound; 2008 Feb;36(2):110-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastasis from a primary angiosarcoma of the scalp to the colon: sonographic and CT findings.
  • We report a case of metastasis to the colon from a primary angiosarcoma of the scalp in a 61-year-old Japanese man and describe the sonographic features and CT findings, with a brief discussion of the clinical and histopathologic findings.
  • Although this entity is extremely rare, it should be considered when a patient with prior diagnosis of angiosarcoma in another organ has focal thickening with preserved compressibility of the wall of the colon.
  • [MeSH-major] Colonic Neoplasms / secondary. Head and Neck Neoplasms / pathology. Hemangiosarcoma / secondary. Scalp. Skin Neoplasms / pathology. Tomography, X-Ray Computed / methods. Ultrasonography, Doppler / methods
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged

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  • [Copyright] (c) 2007 Wiley Periodicals, Inc.
  • (PMID = 17636504.001).
  • [ISSN] 0091-2751
  • [Journal-full-title] Journal of clinical ultrasound : JCU
  • [ISO-abbreviation] J Clin Ultrasound
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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92. Bertazzolo W, Dell'Orco M, Bonfanti U, Ghisleni G, Caniatti M, Masserdotti C, Antoniazzi E, Crippa L, Roccabianca P: Canine angiosarcoma: cytologic, histologic, and immunohistochemical correlations. Vet Clin Pathol; 2005;34(1):28-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Canine angiosarcoma: cytologic, histologic, and immunohistochemical correlations.
  • BACKGROUND: Angiosarcomas (AS) are malignant tumors that arise from vascular endothelial cells and are common in dogs.
  • Immunohistochemically, tumor cells in 16 cases were positive for both endothelial markers tested (Factor VIII-related antigen [FVIII-ra] and CD31 antigen), 2 were positive for CD31 only, and 1 was positive for FVIII-ra only.
  • CONCLUSIONS: The cytologic characteristics of canine AS are widely heterogeneous, but supplementary findings can provide clues that are useful for making a cytologic diagnosis.

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  • (PMID = 15732014.001).
  • [ISSN] 0275-6382
  • [Journal-full-title] Veterinary clinical pathology
  • [ISO-abbreviation] Vet Clin Pathol
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
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93. Tada Y, Takiguchi Y, Terada J, Yoshida T, Shinozaki A, Sakao S, Kasahara Y, Kurosu K, Tanabe N, Tatsumi K, Hiroshima K, Kuriyama T: [A case of angiosarcoma of pelvis with pulmonary metastases which responded to paclitaxel]. Gan To Kagaku Ryoho; 2007 Dec;34(13):2275-7
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  • [Title] [A case of angiosarcoma of pelvis with pulmonary metastases which responded to paclitaxel].
  • Biopsy of the bone lesion established a diagnosis of angiosarcoma.
  • [MeSH-major] Antineoplastic Agents, Phytogenic / therapeutic use. Bone Neoplasms / drug therapy. Hemangiosarcoma / drug therapy. Lung Neoplasms / secondary. Paclitaxel / therapeutic use. Pelvic Bones

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  • (PMID = 18079629.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; P88XT4IS4D / Paclitaxel
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94. Joo YT, Jeong CY, Jung EJ, Lee YJ, Hong SC, Choi SK, Park ST, Ha WS: Intra-abdominal angiosarcoma developing in a capsule of a foreign body: report of a case with associated hemorrhagic diathesis. World J Surg Oncol; 2005 Sep 14;3:60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intra-abdominal angiosarcoma developing in a capsule of a foreign body: report of a case with associated hemorrhagic diathesis.
  • BACKGROUND: Angiosarcoma occurs very rarely in the gastrointestinal tract and can present great diagnostic difficulty, especially when it is associated with intraabdominal abscess or granulation tissue.
  • CASE PRESENTATION: We report a case where the angiosarcoma was diagnosed after the occurrence of disseminated angiosarcoma and concurrent hemoperitoneum.
  • The tumor developed in the fibrous capsule of a foreign body, which was possibly related to the previous appendectomy twenty years ago, and became a widely disseminated malignant neoplasm in the abdomen.
  • Pathologic examination of the multiple intra-abdominal lesions showed the histological and immunohistological characteristics of the angiosarcoma.
  • CONCLUSION: Even though angiosarcoma in the gastrointestinal tract is extremely rare, when dealing with intraabdominal abscess or the gastrointestinal bleeding in patients who have undergone surgery or radiation therapy in the past, the possibility of angiosarcoma should be considered.
  • To make the definite diagnosis of angiosarcoma and to avoid the misdiagnosis of foreign body granuloma, thorough histological examination and immunohistochemical staining may be prerequisite.

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  • (PMID = 16159405.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1242259
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95. Santo K, Dandekar U: Primary right atrial angiosarcoma. Asian Cardiovasc Thorac Ann; 2008 Dec;16(6):490-1

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary right atrial angiosarcoma.
  • A rare case of right atrial angiosarcoma is described in a 55-year-old man who was admitted with acute chest pain.
  • Emergency surgery was performed to excise a right atrial tumor, which histology confirmed to be an angiosarcoma.
  • [MeSH-major] Heart Atria / pathology. Heart Neoplasms / diagnosis. Hemangiosarcoma / diagnosis

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  • (PMID = 18984761.001).
  • [ISSN] 1816-5370
  • [Journal-full-title] Asian cardiovascular & thoracic annals
  • [ISO-abbreviation] Asian Cardiovasc Thorac Ann
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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96. Egea Valenzuela J, López Poveda MJ, Pérez Fuenzalida FJ, Garre Sánchez C, Martínez Barba E, Carballo Alvarez F: Hepatic angiosarcoma. Presentation of two cases. Rev Esp Enferm Dig; 2009 Jun;101(6):430-4, 434-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hepatic angiosarcoma. Presentation of two cases.
  • Hepatic angiosarcoma is a rare primary tumor of the liver with a mesenchymal origin.
  • Diagnosis is difficult because clinical manifestations and imaging studies are inconclusive.
  • In many cases a diagnosis is obtained during necropsy, not being apparent during the course of disease.
  • When clinical manifestations begin progression is often fast, and possibilities for curative treatment are limited.We report two cases of hepatic angiosarcoma.
  • A diagnosis was reached during necropsy.
  • In the second case, we initiated the study of a chronic liver disease using fine-needle aspiration biopsy, which showed findings suggestive of hepatic angiosarcoma.
  • [MeSH-major] Hemangiosarcoma. Liver Neoplasms

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  • (PMID = 19630468.001).
  • [ISSN] 1130-0108
  • [Journal-full-title] Revista española de enfermedades digestivas : organo oficial de la Sociedad Española de Patología Digestiva
  • [ISO-abbreviation] Rev Esp Enferm Dig
  • [Language] eng; spa
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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97. Wiwatwongwana D, White VA, Dolman PJ: Two cases of periocular cutaneous angiosarcoma. Ophthal Plast Reconstr Surg; 2010 Sep-Oct;26(5):365-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Two cases of periocular cutaneous angiosarcoma.
  • Angiosarcoma is a rare malignancy with only 8 previous reports of eyelid involvement.
  • [MeSH-major] Eyelid Neoplasms / pathology. Hemangiosarcoma / pathology. Hemangiosarcoma / secondary. Lung Neoplasms / secondary. Neoplasm Recurrence, Local / diagnosis. Skin Neoplasms / pathology

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  • [CommentIn] Ophthal Plast Reconstr Surg. 2012 Sep-Oct;28(5):386-7; author reply 387 [22965021.001]
  • (PMID = 20856078.001).
  • [ISSN] 1537-2677
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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98. Oztürk E, Mutlu H, Sönmez G, Sildiroğlu HO: Primary angiosarcoma of the spleen. Turk J Gastroenterol; 2007 Dec;18(4):272-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary angiosarcoma of the spleen.
  • Primary angiosarcoma of the spleen is a rare neoplasm with a very poor prognosis.
  • We present computed tomography and magnetic resonance imaging of a 49-year-old man with primary splenic angiosarcoma and liver metastasis.
  • The literature on primary splenic angiosarcoma is reviewed and imaging variability of this rare tumor is discussed.
  • [MeSH-major] Hemangiosarcoma / diagnosis. Splenic Neoplasms / diagnosis

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  • (PMID = 18080928.001).
  • [ISSN] 2148-5607
  • [Journal-full-title] The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
  • [ISO-abbreviation] Turk J Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Turkey
  • [Number-of-references] 23
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99. West J, Liao SY, Cho D: Angiosarcoma after breast conservation: diagnostic pitfalls. Clin Breast Cancer; 2008 Feb;8(1):94-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma after breast conservation: diagnostic pitfalls.
  • Angiosarcomas are aggressive tumors of endovascular origin.
  • Although angiosarcomas are relatively rare, they are being reported with increasing frequency in patients who have previously undergone breast conserving therapy.
  • The initial clinical presentation of angiosarcomas after breast irradiation is often similar to the presentation of recurrent breast carcinomas.
  • In addition, the histologic and cytologic appearance of posttreatment angiosarcomas can be highly suggestive of recurrent breast carcinoma.
  • An accurate diagnosis is essential, because prognosis and treatment are different for each condition.
  • An early and accurate diagnosis is aided by a high index of suspicion by clinician and pathologist.
  • Herein, a case history is presented that underscores the pitfalls in attempting to achieve an accurate diagnosis.
  • [MeSH-major] Breast Neoplasms / surgery. Hemangiosarcoma / pathology. Neoplasms, Second Primary / pathology
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Mastectomy, Segmental. Middle Aged

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  • (PMID = 18501065.001).
  • [ISSN] 1526-8209
  • [Journal-full-title] Clinical breast cancer
  • [ISO-abbreviation] Clin. Breast Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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100. Armah HB, Rao UN, Parwani AV: Primary angiosarcoma of the testis: report of a rare entity and review of the literature. Diagn Pathol; 2007;2:23
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary angiosarcoma of the testis: report of a rare entity and review of the literature.
  • BACKGROUND: Primary testicular angiosarcomas are extremely rare, and their clinicopathologic features are not well described.
  • Our objective was to further define the clinical features and pathologic spectra of primary testicular angiosarcomas.
  • After excluding 2 cases because they did not involve the testis, we identified 4 previously reported cases of true primary testicular angiosarcoma.
  • We also searched the electronic medical archival records of our institution and identified one additional unreported case of true primary testicular angiosarcomas.
  • Data were extracted on the demographics, predisposing factors, clinical presentation, gross pathology, microscopic pathology, immunophenotype, therapy, and outcomes of each of these 5 cases of true primary testicular angiosarcomas.
  • RESULTS: Primary testicular angiosarcomas were found at a mean age of 43.4 years.
  • One patient had multiple metastatic recurrences but eventual outcome was not available, and 1 patient died a month after diagnosis from stroke but no autopsy was performed.
  • CONCLUSION: Primary testicular angiosarcomas are typically rare tumors of men of all ages that appear to segregate into 2 groups; one associated with teratoma and occurring in young people, and the other occurring in the elderly and not associated with germ cell neoplasm, but may be associated with chronic hydrocele.
  • They present with advanced disease and show a wide histologic spectrum.

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  • (PMID = 17601346.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1919353
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