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1. Gkalpakiotis S, Arenberger P, Vohradnikova O, Arenbergerova M: Successful radiotherapy of facial angiosarcoma. Int J Dermatol; 2008 Nov;47(11):1190-2
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  • [Title] Successful radiotherapy of facial angiosarcoma.
  • Cutaneous angiosarcoma of the face and scalp is a rare malignant vascular tumor that affects mostly Caucasian elderly males.
  • Due to the difficult histologic evaluation, high local recurrence and tendency to early metastasing, angiosarcoma poses generally a very poor prognosis.
  • We report the case of an 80-year-old patient who experienced successful removal of large, exophytic growing angiosarcoma of the face achieved with radiotherapy with long-term relapse-free survival.
  • [MeSH-major] Hemangiosarcoma / radiotherapy. Nose Neoplasms / radiotherapy. Skin Neoplasms / radiotherapy

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  • (PMID = 18986458.001).
  • [ISSN] 1365-4632
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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2. Souza FF, Katkar A, den Abbeele AD, Dipiro PJ: Breast angiosarcoma metastatic to the ovary. Case Rep Med; 2009;2009:381015
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  • [Title] Breast angiosarcoma metastatic to the ovary.
  • Primary angiosarcoma can arise anywhere in the body and when it arises in the breast, it usually affects women in their 3rd and 4th decades and accounts for one in 1700-2300 cases of primary breast cancer.
  • Although unusual, breast angiosarcomas tend to metastasize hematogenously rather than lymphogenously, have high rates of local recurrence, that often develop metastases soon after treatment, and have a dismal prognosis.
  • We present a case of a solitary ovarian metastasis from angiosarcoma of the breast.

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  • [Cites] Breast Cancer. 2006;13(4):369-73 [17146165.001]
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  • (PMID = 19718246.001).
  • [ISSN] 1687-9627
  • [Journal-full-title] Case reports in medicine
  • [ISO-abbreviation] Case Rep Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2729273
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3. Lau OD, Bhuta S, Smart CN, Kirsch CM, St John MA: Radiology quiz case 1. Metastatic cutaneous angiosarcoma of the scalp with perineural spread. Arch Otolaryngol Head Neck Surg; 2010 Apr;136(4):411; 413
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Radiology quiz case 1. Metastatic cutaneous angiosarcoma of the scalp with perineural spread.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Hemangiosarcoma / radiography. Hemangiosarcoma / secondary. Scalp. Skin Neoplasms / pathology

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  • (PMID = 20403861.001).
  • [ISSN] 1538-361X
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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4. den Hoed ID, Granzen B, Granzen B, Aronson DC, Pauwels P, de Kraker J, van Heurn LW: Metastasized angiosarcoma of the spleen in a 2-year-old girl. Pediatr Hematol Oncol; 2005 Jul-Aug;22(5):387-90
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  • [Title] Metastasized angiosarcoma of the spleen in a 2-year-old girl.
  • Primary angiosarcoma of the spleen is rare and the prognosis is very poor.
  • The authors present a 2-year-old girl with spontaneous rupture of splenic angiosarcoma.
  • At diagnosis there were liver metastases.
  • She remained in complete remission over 2 years from diagnosis.
  • [MeSH-major] Hemangiosarcoma / secondary. Liver Neoplasms / secondary. Splenic Neoplasms / pathology

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  • (PMID = 16020128.001).
  • [ISSN] 0888-0018
  • [Journal-full-title] Pediatric hematology and oncology
  • [ISO-abbreviation] Pediatr Hematol Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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5. Tong GX, Hamele-Bena D, Borczuk A, Monaco S, Khosh MM, Greenebaum E: Fine needle aspiration biopsy of epithelioid hemangioendothelioma of the oral cavity: report of one case and review of literature. Diagn Cytopathol; 2006 Mar;34(3):218-23
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  • [Title] Fine needle aspiration biopsy of epithelioid hemangioendothelioma of the oral cavity: report of one case and review of literature.
  • Epithelioid hemangioendothelioma (EHE) is an uncommon vascular tumor with biological behavior intermediate between hemangioma and angiosarcoma.
  • Histologic sections and immunohistochemical stains confirmed the diagnosis of EHE.
  • We believe that the diagnosis of this rare tumor can be suggested when an adequate FNA specimen is obtained.
  • [MeSH-major] Hemangioendothelioma, Epithelioid / pathology. Mouth Neoplasms / pathology

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  • [Copyright] 2006 Wiley-Liss, Inc.
  • (PMID = 16470861.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Antigens, CD34
  • [Number-of-references] 45
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6. Shimada K, Nakamoto Y, Isoda H, Saito H, Arizono S, Shibata T, Togashi K: FDG PET for giant cavernous hemangioma: important clue to differentiate from a malignant vascular tumor in the liver. Clin Nucl Med; 2010 Dec;35(12):924-6
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  • [Title] FDG PET for giant cavernous hemangioma: important clue to differentiate from a malignant vascular tumor in the liver.
  • Giant cavernous hemangioma of the liver sometimes has a very inhomogeneous appearance with intratumoral degeneration on computed tomography or magnetic resonance imaging, and may mimic a malignant hepatic tumor, including angiosarcoma.
  • There are many reports about F-18 fluorodeoxyglucose (FDG) uptake of angiosarcoma; however, knowledge regarding positron emission tomography findings with FDG for giant hepatic cavernous hemangioma is still limited.
  • We herein present 2 cases of giant hepatic cavernous hemangioma in which low FDG uptake was considered helpful to differentiate from malignant hepatic tumor.
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Middle Aged

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  • (PMID = 21206221.001).
  • [ISSN] 1536-0229
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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7. Long CT, Luong R: What's your diagnosis. Tail mass in a mouse. Cutaneous hemangiosarcoma. Lab Anim (NY); 2009 Feb;38(2):49-51
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  • [Title] What's your diagnosis. Tail mass in a mouse. Cutaneous hemangiosarcoma.
  • [MeSH-major] Hemangiosarcoma / veterinary. Skin Neoplasms / veterinary
  • [MeSH-minor] Angiomatosis / diagnosis. Animals. Animals, Outbred Strains. Diagnosis, Differential. Fatal Outcome. Female. Hemangioma / diagnosis. Hematoma / diagnosis. Mice. Tail

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  • (PMID = 19165190.001).
  • [ISSN] 0093-7355
  • [Journal-full-title] Lab animal
  • [ISO-abbreviation] Lab Anim (NY)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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8. Azimi NA, Selter JG, Abott JD, Cabin HS, Hutner A, Copel J, Setaro JF: Angiosarcoma in a pregnant woman presenting with pericardial tamponade--a case report and review of the literature. Angiology; 2006 Mar-Apr;57(2):251-7
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  • [Title] Angiosarcoma in a pregnant woman presenting with pericardial tamponade--a case report and review of the literature.
  • The authors present a rare case of pericardial tamponade complicating pregnancy with resulting diagnosis of angiosarcoma.
  • They review the literature involving pericardial disease in pregnancy and discuss important issues in management and include a discussion of angiosarcoma.
  • [MeSH-major] Cardiac Tamponade / etiology. Heart Neoplasms / complications. Hemangiosarcoma / complications. Pregnancy Complications, Neoplastic
  • [MeSH-minor] Adult. Biopsy. Cardiac Surgical Procedures / methods. Diagnosis, Differential. Echocardiography. Female. Follow-Up Studies. Heart Atria. Humans. Magnetic Resonance Imaging. Pericardial Effusion / complications. Pericardial Effusion / diagnosis. Pericardial Effusion / surgery. Pregnancy. Tomography, X-Ray Computed

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  • (PMID = 16518537.001).
  • [ISSN] 0003-3197
  • [Journal-full-title] Angiology
  • [ISO-abbreviation] Angiology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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9. Bhattacharya P, Singh P, Bahal A, Gulati D, Tevatia MS, Mehta A, Muttagikar MP: Angiosarcoma of pericardium: a report of two cases. Indian J Pathol Microbiol; 2007 Oct;50(4):777-9
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  • [Title] Angiosarcoma of pericardium: a report of two cases.
  • Angiosarcomas are uncommon malignant neoplasms characterized by rapidly proliferating extensively infiltrating anaplastic cells derived from blood vessels and lining irregular, blood-filled spaces.
  • Here we present two cases of pericardial angiosarcoma, one of them showing widespread dissemination, which caused considerable diagnostic dilemma and the diagnosis could only be established very late in their course of disease.
  • [MeSH-major] Hemangiosarcoma / diagnosis. Hemangiosarcoma / pathology. Pericardium / pathology
  • [MeSH-minor] Adult. Fatal Outcome. Humans. Male. Middle Aged. Neoplasm Metastasis / diagnosis. Neoplasm Metastasis / pathology

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  • (PMID = 18306551.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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10. Koontz BF, Miles EF, Rubio MA, Madden JF, Fisher SR, Scher RL, Brizel DM: Preoperative radiotherapy and bevacizumab for angiosarcoma of the head and neck: two case studies. Head Neck; 2008 Feb;30(2):262-6
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  • [Title] Preoperative radiotherapy and bevacizumab for angiosarcoma of the head and neck: two case studies.
  • BACKGROUND: Angiosarcoma of the face is a vascular tumor with poor local control and short median survival despite standard treatment.
  • Bevacizumab is a humanized monoclonal antibody to vascular endothelial growth factor (VEGF), which can inhibit tumor growth.
  • Given the vascular nature of angiosarcoma and the need for better treatment of this disease, we investigated the concurrent use of bevacizumab with preoperative radiotherapy for head and neck angiosarcoma.
  • METHODS: Two patients diagnosed with angiosarcoma of the nose were treated preoperatively with bevacizumab (5-10 mg/kg) and concurrent radiotherapy (50 Gy), followed by resection of the tumor bed.
  • RESULTS: Both patients had a complete pathologic response with no residual disease.
  • [MeSH-major] Angiogenesis Inhibitors / therapeutic use. Antibodies, Monoclonal / therapeutic use. Head and Neck Neoplasms / drug therapy. Head and Neck Neoplasms / radiotherapy. Hemangiosarcoma / drug therapy. Hemangiosarcoma / radiotherapy

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  • (PMID = 17685450.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 2S9ZZM9Q9V / Bevacizumab
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11. Mejía AF, Gierbolini L, Jacob B, Westmoreland SV: Pediatric hepatic hemangiosarcoma in a rhesus macaque (Macaca mulatta). J Med Primatol; 2009 Apr;38(2):121-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pediatric hepatic hemangiosarcoma in a rhesus macaque (Macaca mulatta).
  • BACKGROUND: Pediatric hepatic angiosarcoma is a rare condition in children with poor prognosis.
  • Hemangiosarcoma in non-human primates is a rare finding.
  • Immunohistochemistry was used to characterize the hepatic hemangiosarcoma.
  • Histopathology confirmed a poorly differentiated hemangiosarcoma.
  • CONCLUSIONS: Hemangiosarcoma in non-human primates has been rarely reported.
  • Diagnosis was confirmed by expression of endothelial-specific markers CD31 and vWF by immunohistochemistry.
  • Due to the young age of this monkey and the particular solid pattern throughout the mass this neoplasm resembles pediatric hepatic angiosarcoma in humans.

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  • (PMID = 18671765.001).
  • [ISSN] 1600-0684
  • [Journal-full-title] Journal of medical primatology
  • [ISO-abbreviation] J. Med. Primatol.
  • [Language] ENG
  • [Grant] United States / NCRR NIH HHS / RR / T32 RR007000; United States / NCRR NIH HHS / RR / U42 RR016021; United States / NCRR NIH HHS / RR / P51 RR000168; United States / NCRR NIH HHS / RR / P40 RR003640; United States / NCRR NIH HHS / RR / 2 P40RR003640; United States / NCRR NIH HHS / RR / T32 RR007000-32; United States / NCRR NIH HHS / RR / RR007000-32
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Denmark
  • [Other-IDs] NLM/ NIHMS93255; NLM/ PMC2664403
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12. Salas S, Stock N, Stoeckle E, Kind M, Bui B, Coindre JM: Chronic lymphedema due to morbid obesity: an exceptional cause of abdominal wall angiosarcoma. Virchows Arch; 2008 Aug;453(2):217-9
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  • [Title] Chronic lymphedema due to morbid obesity: an exceptional cause of abdominal wall angiosarcoma.
  • [MeSH-major] Abdominal Wall / pathology. Hemangiosarcoma / etiology. Lymphedema / etiology. Obesity, Morbid / complications

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  • (PMID = 18560886.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Germany
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13. Hirotsune N, Terada K, Meguro T, Nishino S, Asano T, Manabe T, Toi Y: [Superselective feeder embolization for hemorrhage from cutaneous angiosarcoma in scalp]. No Shinkei Geka; 2005 Oct;33(10):995-9
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  • [Title] [Superselective feeder embolization for hemorrhage from cutaneous angiosarcoma in scalp].
  • The diagnosis of angiosarcoma was confirmed histologically.
  • The early diagnosis by neurosurgeon may lead to improved survival.
  • [MeSH-major] Embolization, Therapeutic / methods. Hemangiosarcoma / complications. Hemorrhage / therapy. Scalp. Skin Neoplasms / complications

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  • (PMID = 16223178.001).
  • [ISSN] 0301-2603
  • [Journal-full-title] No shinkei geka. Neurological surgery
  • [ISO-abbreviation] No Shinkei Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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14. Kim TO, Kim GH, Heo J, Kang DH, Song GA, Cho M: Metastasis of hepatic angiosarcoma to the stomach. J Gastroenterol; 2005 Oct;40(10):1003-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastasis of hepatic angiosarcoma to the stomach.
  • [MeSH-major] Hemangiosarcoma / secondary. Liver Neoplasms / pathology. Stomach Neoplasms / secondary

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  • (PMID = 16261442.001).
  • [ISSN] 0944-1174
  • [Journal-full-title] Journal of gastroenterology
  • [ISO-abbreviation] J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Japan
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15. Culp WT, Weisse C, Kellogg ME, Gordon IK, Clarke DL, May LR, Drobatz KJ: Spontaneous hemoperitoneum in cats: 65 cases (1994-2006). J Am Vet Med Assoc; 2010 May 1;236(9):978-82
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  • Cats were included if a definitive diagnosis of spontaneous hemoperitoneum could be obtained from review of the medical records.
  • Hemangiosarcoma was the most often diagnosed neoplasm (18/30; 60%), and the spleen was the most common location for neoplasia (11/30; 37%).
  • Cats with neoplasia were significantly older and had significantly lower PCVs than cats with non-neoplastic disease.

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  • (PMID = 20433398.001).
  • [ISSN] 0003-1488
  • [Journal-full-title] Journal of the American Veterinary Medical Association
  • [ISO-abbreviation] J. Am. Vet. Med. Assoc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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16. Canler J, Couraud S, Etienne-Mastroïanni B, Girard N, Benabidallah S, Cordier JF: [Pulmonary metastatic angiosarcoma]. Rev Prat; 2009 Oct 20;59(8):1047
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Pulmonary metastatic angiosarcoma].
  • [Transliterated title] Angiosarcome métastatique pulmonaire.
  • [MeSH-major] Hemangiosarcoma / pathology. Hemangiosarcoma / secondary. Lung Neoplasms / secondary

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  • (PMID = 19894437.001).
  • [ISSN] 0035-2640
  • [Journal-full-title] La Revue du praticien
  • [ISO-abbreviation] Rev Prat
  • [Language] fre
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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17. Williams S, Romaguera R, Kava B: Angiosarcoma of the bladder: case report and review of the literature. ScientificWorldJournal; 2008;8:508-11
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  • [Title] Angiosarcoma of the bladder: case report and review of the literature.
  • Our objective was to present a new case of angiosarcoma of the bladder after therapeutic radiation of the prostate, and discuss the treatment and clinical course of this rare tumor; the role of multimodality treatment is also discussed.
  • We report a case of angiosarcoma of the bladder.
  • A MEDLINE search of all reported cases of angiosarcoma in the English language literature was performed.
  • Thirteen previous cases of bladder angiosarcoma have been reported and three previous cases have been reported after therapeutic radiation.
  • Angiosarcoma of the bladder is a rare disease with overall poor prognosis.
  • [MeSH-major] Hemangiosarcoma / diagnosis. Hemangiosarcoma / therapy. Urinary Bladder Neoplasms / diagnosis. Urinary Bladder Neoplasms / therapy
  • [MeSH-minor] Aged. Humans. Male. Rare Diseases / diagnosis. Rare Diseases / therapy

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  • (PMID = 18516471.001).
  • [ISSN] 1537-744X
  • [Journal-full-title] TheScientificWorldJournal
  • [ISO-abbreviation] ScientificWorldJournal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Number-of-references] 15
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18. Courtwright A, Siamakpour-Reihani S, Arbiser JL, Banet N, Hilliard E, Fried L, Livasy C, Ketelsen D, Nepal DB, Perou CM, Patterson C, Klauber-Demore N: Secreted frizzle-related protein 2 stimulates angiogenesis via a calcineurin/NFAT signaling pathway. Cancer Res; 2009 Jun 1;69(11):4621-8
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  • SFRP2 inhibited hypoxia induced endothelial cell apoptosis, increased endothelial cell migration, and induced endothelial tube formation.
  • The canonical Wnt pathway was not affected by SFRP2 in endothelial cells; however, a component of the noncanonical Wnt/Ca2+ pathway was affected by SFRP2 as shown by an increase in NFATc3 in the nuclear fraction of SFRP2-treated endothelial cells.
  • Tacrolimus, a calcineurin inhibitor that inhibits dephosphorylation of NFAT, inhibited SFRP2-induced endothelial tube formation.
  • Tacrolimus 3 mg/kg/d inhibited the growth of SVR angiosarcoma xenografts in mice by 46% (P = 0.04).

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  • (PMID = 19458075.001).
  • [ISSN] 1538-7445
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA142657; United States / NCI NIH HHS / CA / CA098034-05; United States / NCI NIH HHS / CA / P50 CA058223-160023; None / None / / R01 AR047901-06A2; United States / NCI NIH HHS / CA / K08 CA098034-05; United States / NCI NIH HHS / CA / P50 CA058223-160024; United States / NIAMS NIH HHS / AR / R01 AR02030; United States / NCI NIH HHS / CA / P50 CA058223; United States / NCI NIH HHS / CA / P50-CA58223; United States / NIAMS NIH HHS / AR / R01 AR047901-06A2; United States / NCI NIH HHS / CA / CA058223-160024; United States / NCI NIH HHS / CA / 1 K08CA098034-01A2; United States / NIAMS NIH HHS / AR / R01 AR047901; United States / NCI NIH HHS / CA / K08 CA098034; United States / NCI NIH HHS / CA / CA058223-160023
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Membrane Proteins; 0 / NFATC Transcription Factors; 0 / RNA, Small Interfering; 0 / SFRP2 protein, human; EC 3.1.3.16 / Calcineurin
  • [Other-IDs] NLM/ NIHMS108837; NLM/ PMC2699405
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19. Warman SM, McGregor R, Fews D, Ferasin L: Congestive heart failure caused by intracardiac tumours in two dogs. J Small Anim Pract; 2006 Aug;47(8):480-3
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  • Case 1 showed signs of left-sided heart failure caused by osteosarcoma within the left atrial lumen, and case 2 presented with clinical signs of right-sided heart failure due to haemangiosarcoma occupying the right atrial and ventricular lumens.
  • This case report provides further evidence for the inclusion of intracardiac neoplasia in the differential diagnosis for dogs with clinical signs of congestive heart failure.
  • [MeSH-major] Dog Diseases / diagnosis. Heart Failure / veterinary. Heart Neoplasms / veterinary. Hemangiosarcoma / veterinary. Osteosarcoma / veterinary

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  • (PMID = 16911120.001).
  • [ISSN] 0022-4510
  • [Journal-full-title] The Journal of small animal practice
  • [ISO-abbreviation] J Small Anim Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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20. Isoda H, Imai M, Inagawa S, Miura K, Sakahara H: Magnetic resonance imaging findings of angiosarcoma of the scalp. J Comput Assist Tomogr; 2005 Nov-Dec;29(6):858-62
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  • [Title] Magnetic resonance imaging findings of angiosarcoma of the scalp.
  • OBJECTIVE: The purpose of this study was to investigate the magnetic resonance (MR) imaging findings of angiosarcoma of the scalp retrospectively.
  • METHODS: Eight patients with angiosarcoma of the scalp were included in this study.
  • CONCLUSIONS: Magnetic resonance imaging was useful in determining the extent of angiosarcoma of the scalp because it visualized the tumor invasion into surrounding structures that could not be seen on physical inspection.
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Hemangiosarcoma / diagnosis. Magnetic Resonance Imaging / methods. Scalp / pathology. Skin Neoplasms / diagnosis

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  • (PMID = 16272865.001).
  • [ISSN] 0363-8715
  • [Journal-full-title] Journal of computer assisted tomography
  • [ISO-abbreviation] J Comput Assist Tomogr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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21. Pirie CG, Dubielzig RR: Feline conjunctival hemangioma and hemangiosarcoma: a retrospective evaluation of eight cases (1993-2004). Vet Ophthalmol; 2006 Jul-Aug;9(4):227-31
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  • [Title] Feline conjunctival hemangioma and hemangiosarcoma: a retrospective evaluation of eight cases (1993-2004).
  • The purpose of this retrospective study was to evaluate feline primary conjunctival vascular tumors of endothelial origin.
  • Eight cases (six hemangiomas, two hemangiosarcomas) from a collection of 3460 feline submissions between 1993 and 2004 were evaluated using routine hematoxylin and eosin (H&E).
  • Only cases of hemangiosarcoma underwent surgical re-excisions following incomplete excision; however, no further recurrences were reported.
  • No cases evaluated had evidence of metastatic disease at the time of excision.
  • [MeSH-major] Cat Diseases / epidemiology. Conjunctival Neoplasms / veterinary. Hemangioma / veterinary. Hemangiosarcoma / veterinary

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  • (PMID = 16771757.001).
  • [ISSN] 1463-5216
  • [Journal-full-title] Veterinary ophthalmology
  • [ISO-abbreviation] Vet Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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22. Al-Abbadi MA, Almasri NM, Al-Quran S, Wilkinson EJ: Cytokeratin and epithelial membrane antigen expression in angiosarcomas: an immunohistochemical study of 33 cases. Arch Pathol Lab Med; 2007 Feb;131(2):288-92
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  • [Title] Cytokeratin and epithelial membrane antigen expression in angiosarcomas: an immunohistochemical study of 33 cases.
  • CONTEXT: Expression of epithelial cell markers can occur in mesenchymal tumors and has been reported in angiosarcomas with variable frequency.
  • In these situations, establishing the diagnosis becomes problematic.
  • OBJECTIVE: To determine the expression of cytokeratin and epithelial membrane antigen in angiosarcoma.
  • DESIGN: To address this issue, 33 well-documented cases of angiosarcomas were retrieved from the archival material of Shands Hospital at the University of Florida, Gainesville, and Jackson Memorial Hospital at the University of Miami, Miami, Florida.
  • CONCLUSION: Cytokeratin and epithelial membrane antigen immunoreactivity in angiosarcomas is infrequent but may be encountered.
  • Interpretation of such expression should be done with caution and in conjunction with the characteristic clinical and morphologic features of the tumor as well as the expression of endothelial cell antigens.
  • [MeSH-major] Biomarkers, Tumor / analysis. Hemangiosarcoma / pathology. Keratins / metabolism. Mucin-1 / metabolism

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  • (PMID = 17284115.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Mucin-1; 68238-35-7 / Keratins
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23. Taib N, Yip Ch, Ranganathan S, Moosa F, Mun K: Haemorrhaging lesion in the breast: is there a role for embolisation? Biomed Imaging Interv J; 2006 Jul;2(3):e30
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  • Angiosarcoma of the breast is an extremely rare condition.
  • This case illustrates the use of embolisation as a modality of treatment for primary breast angiosarcoma.
  • No other case has been reported on the use of embolisation for this disorder.

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  • (PMID = 21614243.001).
  • [ISSN] 1823-5530
  • [Journal-full-title] Biomedical imaging and intervention journal
  • [ISO-abbreviation] Biomed Imaging Interv J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Malaysia
  • [Other-IDs] NLM/ PMC3097628
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24. Kato W, Usui A, Oshima H, Suzuki C, Kato K, Ueda Y: Primary aortic intimal sarcoma. Gen Thorac Cardiovasc Surg; 2008 May;56(5):236-8
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  • [Title] Primary aortic intimal sarcoma.
  • Aortic intimal angiosarcoma is extremely rare, and the prognosis of patients with a tumor is unfavorable even if they have undergone surgery.
  • We treated a patient with primary intimal angiosarcoma of the aortic arch who underwent an operation.
  • On histologic examination, an undifferentiated intimal sarcoma was diagnosed.
  • According to some reports endoarterectomy has been performed to treat this type of tumor, since the malignant cells are thought to be limited to the luminal surface.
  • [MeSH-major] Aorta, Thoracic / pathology. Hemangiosarcoma / pathology. Tunica Intima / pathology. Vascular Neoplasms / pathology

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  • [Cites] Circ J. 2002 Jan;66(1):111-3 [11999659.001]
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  • (PMID = 18470690.001).
  • [ISSN] 1863-6705
  • [Journal-full-title] General thoracic and cardiovascular surgery
  • [ISO-abbreviation] Gen Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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25. Gamlem H, Nordstoga K: Canine vascular neoplasia--histologic classification and inmunohistochemical analysis of 221 tumours and tumour-like lesions. APMIS Suppl; 2008;(125):19-40
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  • Four main categories of tumours are reported, i.e. benign types: haemangiomas (n=127) and lymphangioma (n=1); tumour-like lesions: papillary endothelial hyperplasia (n=8) and vascular ectasias (n=2); neoplasms of intermediate malignancy: haemangioendotheliomas (n=27), and the obvious malignant form: angiosarcomas (n=57).
  • Papillary endothelial hyperplasia and arteriovenous and venous haemangiomas are described for the first time in dogs.
  • The combination of conventional histopathologic methods and immunohistochemistry was in many cases very useful diagnostically, the latter technique being in some cases indispensable for establishing a definite diagnosis.
  • In general CD31 was the most useful marker for tumours originating from endothelial cells, especially for poorly differentiated haemangiosarcomas.
  • [MeSH-minor] Animals. Antigens, CD31 / analysis. Dogs. Hemangioendothelioma / pathology. Hemangioendothelioma / veterinary. Hemangioma / pathology. Hemangioma / veterinary. Hemangiosarcoma / pathology. Hemangiosarcoma / veterinary. Immunohistochemistry. Lymphangioma / pathology. Lymphangioma / veterinary. Vimentin / analysis. von Willebrand Factor / analysis

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  • (PMID = 19385279.001).
  • [ISSN] 0903-465X
  • [Journal-full-title] APMIS. Supplementum
  • [ISO-abbreviation] APMIS Suppl.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Vimentin; 0 / von Willebrand Factor
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26. Mignogna C, Simonetti S, Galloro G, Magno L, De Cecio R, Insabato L: Duodenal epithelioid angiosarcoma: immunohistochemical and clinical findings. A case report. Tumori; 2007 Nov-Dec;93(6):619-21
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  • [Title] Duodenal epithelioid angiosarcoma: immunohistochemical and clinical findings. A case report.
  • Angiosarcomas are uncommon malignant tumors of vascular endothelium that represent less than 1% of all sarcomas.
  • The epithelioid variant of angiosarcomas is exceptionally rare, and the gastrointestinal tract is rarely involved.
  • Angiosarcomas mainly involve skin and soft tissue and rarely occur in breast, liver, bone, and spleen.
  • A duodenal reddish polypoid lesion was found, which on microscopic examination turned out to be an epithelioid angiosarcoma.
  • The immunohistochemical features of the lesion supported this diagnosis.
  • The patient died eight months after the diagnosis.
  • Epithelioid angiosarcoma is an aggressive variant of angiosarcoma and must be considered in the differential diagnosis of gastrointestinal tumors.
  • [MeSH-major] Duodenal Neoplasms / pathology. Hemangioendothelioma, Epithelioid / pathology. Hemangiosarcoma / pathology

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  • (PMID = 18338501.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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27. Sluzevich JC, Gloster HJ, Mutasim DF: A case of regressing central facial cutaneous angiosarcoma. J Am Acad Dermatol; 2008 May;58(5 Suppl 1):S113-5
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  • [Title] A case of regressing central facial cutaneous angiosarcoma.
  • [MeSH-major] Eyelid Neoplasms / pathology. Hemangiosarcoma / pathology. Skin Neoplasms / pathology

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  • (PMID = 18489041.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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28. Korkolis DP, Papaevangelou M, Koulaxouzidis G, Zirganos N, Psichogiou H, Vassilopoulos PP: Intravascular papillary endothelial hyperplasia (Masson's hemangioma) presenting as a soft-tissue sarcoma. Anticancer Res; 2005 Mar-Apr;25(2B):1409-12
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  • [Title] Intravascular papillary endothelial hyperplasia (Masson's hemangioma) presenting as a soft-tissue sarcoma.
  • Intravascular papillary endothelial hyperplasia (Masson's hemangioma) is an unusual benign, non-neoplastic, vascular lesion characterized histologically by papillary fronds lined by proliferating endothelium.
  • The main significance of intravascular papillary endothelial hyperplasia is its clinical and histological resemblance to soft-tissue sarcoma and possible misinterpretation as such.
  • A case of intravascular papillary endothelial hyperplasia clinically diagnosed and treated as a low-grade angiosarcoma, in a 60-year-old man, presenting with a mass in the left thigh, is reported.
  • [MeSH-major] Hemangioendothelioma / diagnosis. Thigh
  • [MeSH-minor] Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Sarcoma / diagnosis. Soft Tissue Neoplasms / diagnosis


29. Wang X, Wang X, Liang D, Lan K, Guo W, Ren G: Classic Kaposi's sarcoma in Han Chinese and useful tools for differential diagnosis. Oral Oncol; 2010 Sep;46(9):654-6
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  • [Title] Classic Kaposi's sarcoma in Han Chinese and useful tools for differential diagnosis.
  • Kaposi's sarcoma (KS) is a common AIDS-related malignant neoplasm in the head and neck region, especially in the oral cavity, but is rarely described in the HIV-negative and non-immunosuppressed individual.
  • The lesions were diagnosed as angiosarcomas twice.
  • The clinical presentation, therapeutic options, and tools for differentiating Kaposi sarcoma from other vascular and nonvascular spindle cell lesions are presented, and the relevant literature is reviewed.
  • [MeSH-major] HIV Seronegativity. Head and Neck Neoplasms / pathology. Hemangiosarcoma / pathology. Sarcoma, Kaposi / pathology
  • [MeSH-minor] China / ethnology. Diagnosis, Differential. Facial Neoplasms / ethnology. Facial Neoplasms / pathology. Female. Humans. Immune Tolerance. Middle Aged

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  • [Copyright] Copyright 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20656545.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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30. Higashiyama S, Kawabe J, Hayashi T, Kurooka H, Oe A, Kawamura E, Shiomi S: Effectiveness of preoperative PET examination of huge angiosarcoma of the heart. Clin Nucl Med; 2009 Feb;34(2):99-102
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  • [Title] Effectiveness of preoperative PET examination of huge angiosarcoma of the heart.
  • [MeSH-major] Heart Neoplasms / radionuclide imaging. Heart Neoplasms / surgery. Hemangiosarcoma / radionuclide imaging. Hemangiosarcoma / surgery. Preoperative Care

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  • (PMID = 19352263.001).
  • [ISSN] 1536-0229
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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31. Idrees MT, Kuhar M, Ulbright TM, Zhang S, Agaram N, Wang M, Grignon DJ, Eble JN, Cheng L: Clonal evidence for the progression of a testicular germ cell tumor to angiosarcoma. Hum Pathol; 2010 Jan;41(1):139-44
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  • [Title] Clonal evidence for the progression of a testicular germ cell tumor to angiosarcoma.
  • An alternative hypothesis for the development of angiosarcoma in a patient with germ cell tumors is secondary to radiation or chemotherapy.
  • Forty months after his original diagnosis, a mediastinal angiosarcoma was diagnosed.
  • Using tissue microdissection-loss of heterozygosity analysis and fluorescence in situ hybridization, we analyzed the clonality of the primary germ cell tumor, angiosarcoma, and metastatic teratoma.
  • Loss of heterozygosity was demonstrated for microsatellite loci of all 3 chromosomes, and completely concordant loss of heterozygosity patterns were observed among primary germ cell tumor components, metastatic teratoma, and angiosarcoma.
  • Isochromosome 12p and 12p overrepresentations were consistently found in the primary germ cell tumor components, metastatic teratoma, and angiosarcoma.
  • The results indicated a clonal origin of the tumors, which supports that angiosarcoma, as well as the teratomas, arose from the testicular germ cell tumors.
  • [MeSH-major] Hemangiosarcoma / pathology. Mediastinal Neoplasms / pathology. Neoplasms, Second Primary / pathology. Teratoma / secondary. Testicular Neoplasms / pathology
  • [MeSH-minor] Clone Cells. DNA, Neoplasm / analysis. Disease Progression. Disease-Free Survival. Humans. In Situ Hybridization, Fluorescence. Loss of Heterozygosity. Male. Microdissection. Microsatellite Repeats / genetics

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  • (PMID = 19836053.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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32. Wierzbicka-Hainaut E, Guillet G: [Stewart-Treves syndrome (angiosarcoma on lyphoedema): A rare complication of lymphoedema]. Presse Med; 2010 Dec;39(12):1305-8
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  • [Title] [Stewart-Treves syndrome (angiosarcoma on lyphoedema): A rare complication of lymphoedema].
  • [Transliterated title] Syndrome de Stewart-Treves (angiosarcome sur lymphœdème) : complication rare du lymphœdème.
  • [MeSH-major] Lymphedema / complications. Lymphedema / diagnosis
  • [MeSH-minor] Breast Neoplasms / mortality. Breast Neoplasms / surgery. Chronic Disease. Combined Modality Therapy. Female. Hemangiosarcoma / diagnosis. Hemangiosarcoma / etiology. Hemangiosarcoma / mortality. Hemangiosarcoma / therapy. Humans. Lymphangiosarcoma / diagnosis. Lymphangiosarcoma / etiology. Lymphangiosarcoma / mortality. Lymphangiosarcoma / therapy. Mastectomy, Radical. Postoperative Complications / diagnosis. Postoperative Complications / etiology. Postoperative Complications / mortality. Prognosis. Survival Rate

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  • [Copyright] Copyright © 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20970956.001).
  • [ISSN] 2213-0276
  • [Journal-full-title] Presse medicale (Paris, France : 1983)
  • [ISO-abbreviation] Presse Med
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Chemical-registry-number] Stewart Treves syndrome
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33. Chen SY, Huang CZ, Qian Y, Wu Y, Tu YT: [Clinicopathologic study of 8 cases of poorly differentiated cutaneous angiosarcoma of scalp]. Zhonghua Bing Li Xue Za Zhi; 2008 May;37(5):313-5
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  • [Title] [Clinicopathologic study of 8 cases of poorly differentiated cutaneous angiosarcoma of scalp].
  • OBJECTIVE: To study the clinical and pathologic characteristics of poorly differentiated cutaneous angiosarcoma of scalp.
  • METHODS: Eight cases of poorly differentiated cutaneous angiosarcoma of scalp were enrolled into this study.
  • Conclusions Angiosarcoma needs to be excluded by histologic examination whenever bruise-like and erythematous lesions occurring on scalp skin of elderly patients.
  • The endothelial origin of the tumor cells can be confirmed with immunostaining for CD31, CD34 and factor VIII-related antigen.
  • [MeSH-major] Antigens, CD31 / immunology. Antigens, CD34 / immunology. Hemangiosarcoma / immunology. Scalp / pathology. Skin Neoplasms / immunology. Vimentin / analysis

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  • (PMID = 18956649.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Antigens, CD34; 0 / Biomarkers, Tumor; 0 / Cell Adhesion Molecules; 0 / Vimentin
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34. Magri K, Demoulin G, Millon G, Duvert B: [Metastasis to the breast from non mammary metastasis. Clinical, radiological characteristics and diagnostic process. A report of two cases and a review of literature]. J Gynecol Obstet Biol Reprod (Paris); 2007 Oct;36(6):602-6
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  • Their clinical and radiological presentation polymorphic installation a problem of differential diagnosis between benign tumor, like the fibroadenomas on the one hand, and malignant tumors of other share.
  • The presence of multiple, bilateral round tumors, superficial without the traditional signs of malignity which one meets with the primitive tumors: irregular margins, spiculations, microcalcifications, posterior cone of shadow is evocative diagnosis.
  • Pathologic examination completed with immunohistochemical tests is a key point for diagnosis.
  • The search for a primitive tumor is essential, in particular for neuroendocrine carcinoma, stromal sarcoma, and the angiosarcoma which can be primitive tumors of the breast.
  • Treatment is therefore modified, taking into consideration the treatment and prognosis of the primary disease.
  • [MeSH-minor] Aged. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Brain Neoplasms / diagnosis. Brain Neoplasms / secondary. Brain Neoplasms / therapy. Female. Humans. Immunohistochemistry. Lung Neoplasms / diagnosis. Magnetic Resonance Imaging. Mammography. Melanoma / diagnosis. Middle Aged. Radiotherapy

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  • (PMID = 17590284.001).
  • [ISSN] 0368-2315
  • [Journal-full-title] Journal de gynécologie, obstétrique et biologie de la reproduction
  • [ISO-abbreviation] J Gynecol Obstet Biol Reprod (Paris)
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 17
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35. Grégoire F, Mousset B, Hanrez D, Cassart D, Desmecht D, Linden A: Cavernous haemangiosarcoma in a free-living red deer (Cervus elaphus). Vet Rec; 2008 May 24;162(21):692-3
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  • [Title] Cavernous haemangiosarcoma in a free-living red deer (Cervus elaphus).
  • [MeSH-major] Bone Neoplasms / veterinary. Deer. Hemangiosarcoma / veterinary. Lung Neoplasms / veterinary. Ribs

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  • (PMID = 18503071.001).
  • [ISSN] 0042-4900
  • [Journal-full-title] The Veterinary record
  • [ISO-abbreviation] Vet. Rec.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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36. Taira N, Ohsumi S, Aogi K, Maeba T, Kawamura S, Nishimura R, Takashima S: Nodular pseudoangiomatous stromal hyperplasia of mammary stroma in a case showing rapid tumor growth. Breast Cancer; 2005;12(4):331-6
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  • Pseudoangiomatous stromal hyperplasia (PASH) is an uncommon benign breast disease that presents as a localized breast mass.
  • The importance of this benign lesion lies in distinguishing it from low grade angiosarcoma.
  • Based on these findings, a provisional diagnosis of fibroadenoma was made and the patient was followed up.
  • Isolated spindle cells appeared intermittently at the margins of the spaces resembled endothelial cells.
  • Immunohistochemical staining showed that endothelial cells lining true blood vessels were positive for Factor VIII-related antigen, but the spindle cells were negative for Factor VIII.
  • [MeSH-minor] Adult. Diagnosis, Differential. Disease Progression. Female. Humans. Hyperplasia. Stromal Cells / pathology


37. Adhikari M, Wu ML, Zhao X: Gastrointestinal stromal tumor colliding with angiosarcoma. Int J Surg Pathol; 2006 Jul;14(3):252-6
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  • [Title] Gastrointestinal stromal tumor colliding with angiosarcoma.
  • The collision of gastric tumors is rare, and those involving gastrointestinal stromal tumor and angiosarcoma have not been previously reported.
  • This article reports a gastric tumor involving collision of gastrointestinal stromal tumor and angiosarcoma.
  • Occasional prominent foci showed dissecting and anastomosing channels of ectatic vascular spaces lined by cytologically malignant cells that were positive focally for CD117 and diffusely positive for multiple vascular markers, indicating angiosarcoma.
  • [MeSH-major] Gastrointestinal Stromal Tumors / pathology. Hemangiosarcoma / pathology. Neoplasms, Multiple Primary. Stomach Neoplasms / pathology

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  • (PMID = 16959715.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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38. Pohar-Marinsek Z, Lamovec J: Angiosarcoma in FNA smears: diagnostic accuracy, morphology, immunocytochemistry and differential diagnoses. Cytopathology; 2010 Oct;21(5):311-9
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  • [Title] Angiosarcoma in FNA smears: diagnostic accuracy, morphology, immunocytochemistry and differential diagnoses.
  • OBJECTIVE: The aim of our study was to analyse the diagnostic accuracy in recognizing angiosarcoma from fine needle aspiration (FNA) samples and to determine morphological features of angiosarcoma in cytology.
  • METHODS: FNA samples from 18 histologically confirmed angiosarcomas obtained between 1985 and 2009 were included in the study.
  • RESULTS: There were 13 primary angiosarcomas and five recurrent tumours; nine tumours were epithelioid.
  • Twelve tumours were cytologically diagnosed as malignant, three as suspicious and three were judged unsatisfactory.
  • Cytomorphology did not correlate well with histology in mixed and spindle cell types of angiosarcomas.
  • Immunocytochemistry was applied in seven cases, specific vascular marker CD31 only twice at the time of diagnosis and three times retrospectively.
  • CONCLUSIONS: Angiosarcomas are difficult to recognize on FNA smears when they lack the typical dual, spindle and epithelioid cell population and when they occur in internal organs where carcinomas are more common.
  • [MeSH-major] Hemangiosarcoma / pathology
  • [MeSH-minor] Adult. Aged. Antigens, CD31. Biomarkers, Tumor / metabolism. Biopsy, Fine-Needle. Cytodiagnosis. Diagnosis, Differential. Diagnostic Errors. Epithelioid Cells / metabolism. Epithelioid Cells / pathology. Female. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Recurrence, Local. Reproducibility of Results

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  • (PMID = 20105214.001).
  • [ISSN] 1365-2303
  • [Journal-full-title] Cytopathology : official journal of the British Society for Clinical Cytology
  • [ISO-abbreviation] Cytopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Biomarkers, Tumor
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39. Ji J, Hemminki K: Familial blood vessel tumors and subsequent cancers. Ann Oncol; 2007 Jul;18(7):1260-7
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  • Offspring angiosarcoma in the trunk and extremities was associated with maternal breast cancer.
  • Second Kaposi's sarcoma, non-Hodgkin's lymphoma, Hodgkin's disease and myeloma were increased following primary skin Kaposi's sarcoma.
  • CONCLUSIONS: Our data showed that familial clustering of nervous system hemangioblastoma and hemangioma and the risks of subsequent cancers were primarily related to von-Hippel-Lindau disease.
  • Similarly, offspring angiosarcoma is associated with maternal breast cancer.
  • Immunodeficiency may explain the excess of lymphoproliferative diseases after skin Kaposi's sarcoma.

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  • (PMID = 17426058.001).
  • [ISSN] 0923-7534
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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40. Kabukçuoğlu F, Kabukçuoğlu Y, Livaoğlu A, Ozağari A, Armağan R, Kuzgun U: [Epithelioid hemangioendothelioma of bone]. Acta Orthop Traumatol Turc; 2006;40(4):324-8
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  • [Title] [Epithelioid hemangioendothelioma of bone].
  • Epithelioid hemangioendothelioma is a low-grade malignant tumor with a histologic appearance and clinical course between that of a hemangioma and angiosarcoma.
  • Histopathologic examination showed a neoplastic lesion consisting of atypical endothelial cells lining vascular structures or forming solid nests in a myxoid stroma.
  • A diagnosis of epithelioid hemangioendothelioma was made and the patient underwent subtotal resection of the metatarsal bone with reconstruction of the fibula, and a wide resection of the tibial lesion.
  • [MeSH-major] Bone Neoplasms / diagnosis. Hemangioendothelioma, Epithelioid / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Female. Fibula / pathology. Fibula / radiography. Fibula / surgery. Humans. Metatarsal Bones / pathology. Metatarsal Bones / radiography. Metatarsal Bones / surgery. Middle Aged. Tibia / pathology. Tibia / radiography. Tibia / surgery. Wounds and Injuries

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  • (PMID = 17063057.001).
  • [ISSN] 1017-995X
  • [Journal-full-title] Acta orthopaedica et traumatologica turcica
  • [ISO-abbreviation] Acta Orthop Traumatol Turc
  • [Language] tur
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Turkey
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41. Kirova YM, Vilcoq JR, Asselain B, Sastre-Garau X, Fourquet A: Radiation-induced sarcomas after radiotherapy for breast carcinoma: a large-scale single-institution review. Cancer; 2005 Aug 15;104(4):856-63
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  • [Title] Radiation-induced sarcomas after radiotherapy for breast carcinoma: a large-scale single-institution review.
  • BACKGROUND: Sarcomas are a rare complication of radiotherapy for breast carcinoma and patients have a poor prognosis.
  • The incidence, histology, and management of patients with sarcomas were reviewed in the current study.
  • Treatment of radiation-induced sarcomas (RIS) consisted mostly of radical surgery and chemotherapy.
  • RESULTS: Overall, 35 patients developed sarcomas.
  • Thirteen sarcomas were located in the breast, 5- in the chest wall, 3 in the sternum, 2 in the supraclavicle, 1 in the scapula, and 3 in the axilla.
  • Histologic evaluation identified 13 angiosarcomas, 3 osteosarcomas, 5 undifferentiated sarcomas, 1 malignant fibrous histiocytoma, 2 leiomyosarcomas, 1 fibrosarcoma, 1 rhabdomyosarcoma, and 1 myosarcoma.
  • Of the 27 patients, 15 died of sarcoma within 1 month to 14.5 years (mean, 34.2 +/- 0.7 months).
  • The 5-year actuarial survival rate after diagnosis of RIS was 36% (+/- 0.11).
  • [MeSH-major] Breast Neoplasms / radiotherapy. Neoplasms, Radiation-Induced / epidemiology. Sarcoma / epidemiology. Sarcoma / etiology

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  • (PMID = 15981282.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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42. Neragi-Miandoab S, Kim J, Vlahakes GJ: Malignant tumours of the heart: a review of tumour type, diagnosis and therapy. Clin Oncol (R Coll Radiol); 2007 Dec;19(10):748-56
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  • [Title] Malignant tumours of the heart: a review of tumour type, diagnosis and therapy.
  • Primary cardiac neoplasms are rare and occur less commonly than metastatic disease of the heart.
  • In this overview, current published studies concerning malignant neoplasms of the heart are reviewed, together with some insights into their aetiology, diagnosis and management.
  • Sarcomas are the most common cardiac tumours and include myxosarcoma, liposarcoma, angiosarcoma, fibrosarcoma, leiomyosarcoma, osteosarcoma, synovial sarcoma, rhabdomyosarcoma, neurofibrosarcoma, malignant fibrous histiocytoma and undifferentiated sarcoma.
  • The prognosis after surgery is usually excellent in the case of benign tumours, but the prognosis of malignant tumours remains dismal.
  • Therefore, a high level of suspicion is required for early diagnosis.
  • [MeSH-major] Heart Neoplasms. Sarcoma

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  • (PMID = 17693068.001).
  • [ISSN] 0936-6555
  • [Journal-full-title] Clinical oncology (Royal College of Radiologists (Great Britain))
  • [ISO-abbreviation] Clin Oncol (R Coll Radiol)
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 77
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43. Christensen N, Canfield P, Martin P, Krockenberger M, Spielman D, Bosward K: Cytopathological and histopathological diagnosis of canine splenic disorders. Aust Vet J; 2009 May;87(5):175-81
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  • [Title] Cytopathological and histopathological diagnosis of canine splenic disorders.
  • OBJECTIVES: To determine (1) the common types of canine splenic disorders, and the breeds affected, that are diagnosed by cytopathological and histopathological examination in Sydney, Australia and (2) the accuracy of cytopathological examination compared with histopathological examination for the diagnosis of canine splenic disorders.
  • RESULTS: The most common cytopathological diagnoses were benign disorders of growth, vascular disturbances and necrosis (29%), followed by no abnormalities detectable (28%), malignant neoplasms (20%), equivocal diagnoses (20%) and inflammatory disorders (3%).
  • The most common histopathological diagnoses were benign disorders of growth, vascular disturbances and necrosis (49%), followed by malignant neoplasms (43%) and inflammatory disorders (8%).
  • German Shepherd Dogs were the most common breed diagnosed histopathologically with haemangiosarcoma.
  • Although cytopathological and histopathological splenic examinations are complementary for diagnosis, this study has shown a high correlation for complete and partial agreement between the two.

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  • (PMID = 19382924.001).
  • [ISSN] 0005-0423
  • [Journal-full-title] Australian veterinary journal
  • [ISO-abbreviation] Aust. Vet. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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44. Nakamura R, Nagashima T, Sakakibara M, Nakano S, Tanabe N, Fujimoto H, Arai M, Kadowaki M, Oide T, Tanizawa T, Miyazaki M: Angiosarcoma arising in the breast following breast-conserving surgery with radiation for breast carcinoma. Breast Cancer; 2007;14(2):245-9
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  • [Title] Angiosarcoma arising in the breast following breast-conserving surgery with radiation for breast carcinoma.
  • We report a case of angiosarcoma arising in the breast following breast-conserving surgery with radiation therapy for breast carcinoma.
  • Incisional biopsy revealed angiosarcoma of the breast, and total mastectomy was subsequently performed.
  • [MeSH-major] Breast Neoplasms / pathology. Hemangiosarcoma / pathology. Mastectomy, Segmental. Neoplasms, Second Primary / pathology

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  • (PMID = 17485913.001).
  • [ISSN] 1340-6868
  • [Journal-full-title] Breast cancer (Tokyo, Japan)
  • [ISO-abbreviation] Breast Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Selective Estrogen Receptor Modulators; 094ZI81Y45 / Tamoxifen
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45. Hsu JT, Lin CY, Wu TJ, Chen HM, Hwang TL, Jan YY: Splenic angiosarcoma metastasis to small bowel presented with gastrointestinal bleeding. World J Gastroenterol; 2005 Nov 7;11(41):6560-2
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  • [Title] Splenic angiosarcoma metastasis to small bowel presented with gastrointestinal bleeding.
  • Primary splenic angiosarcoma is a very rare, aggressive neoplasm with a high metastatic rate and dismal prognosis.
  • Splenic angiosarcoma with bleeding gastrointestinal metastases is extremely rare.
  • This study reported a 44-year-old male patient with splenic angiosarcoma with sustained repeated gastrointestinal bleeding due to small bowel metastases.
  • The post-operative course was uneventful; the patient survived with the disease and had no GI bleeding, 7 mo after surgery.
  • [MeSH-major] Gastrointestinal Hemorrhage / etiology. Hemangiosarcoma / secondary. Intestinal Neoplasms / secondary. Splenic Neoplasms / pathology

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  • (PMID = 16425436.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4355806
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46. Sorenmo K, Samluk M, Clifford C, Baez J, Barrett JS, Poppenga R, Overley B, Skorupski K, Oberthaler K, Van Winkle T, Seiler G, Shofer F: Clinical and pharmacokinetic characteristics of intracavitary administration of pegylated liposomal encapsulated doxorubicin in dogs with splenic hemangiosarcoma. J Vet Intern Med; 2007 Nov-Dec;21(6):1347-54
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  • [Title] Clinical and pharmacokinetic characteristics of intracavitary administration of pegylated liposomal encapsulated doxorubicin in dogs with splenic hemangiosarcoma.
  • BACKGROUND: Canine splenic hemangiosarcoma (HSA) is a fatal malignancy, and most affected dogs die within a few months of diagnosis.
  • The abdomen is also the main site of disease recurrence.
  • After staging of disease status and splenectomy, pegylated liposomal encapsulated doxorubicin was administered intraperitoneally (1 mg/kg body weight) every 3 weeks for 4 cycles.

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  • (PMID = 18196746.001).
  • [ISSN] 0891-6640
  • [Journal-full-title] Journal of veterinary internal medicine
  • [ISO-abbreviation] J. Vet. Intern. Med.
  • [Language] ENG
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / liposomal doxorubicin; 30IQX730WE / Polyethylene Glycols; 80168379AG / Doxorubicin
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47. Umscheid TW, Rouhani G, Morlang T, Lorey T, Klein PJ, Ziegler P, Stelter WJ: Hemangiosarcoma after endovascular aortic aneurysm repair. J Endovasc Ther; 2007 Feb;14(1):101-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hemangiosarcoma after endovascular aortic aneurysm repair.
  • PURPOSE: To report a rare case of hemangiosarcoma after endovascular aneurysm repair (EVAR).
  • CONCLUSION: Morphological changes of the aneurysm wall seen on computed tomographic scans of EVAR patients may not be incidental or signs of infection; rather, a malignant tumor of the aorta or lymphatic disease, although rare, have to be taken into consideration as well.
  • [MeSH-major] Aortic Aneurysm, Abdominal / surgery. Blood Vessel Prosthesis Implantation / adverse effects. Hemangiosarcoma / etiology. Stents

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  • (PMID = 17291154.001).
  • [ISSN] 1526-6028
  • [Journal-full-title] Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists
  • [ISO-abbreviation] J. Endovasc. Ther.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Polyethylene Terephthalates
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48. Fuller CK, Charlson JA, Dankle SK, Russell TJ: Dramatic improvement of inoperable angiosarcoma with combination paclitaxel and bevacizumab chemotherapy. J Am Acad Dermatol; 2010 Oct;63(4):e83-4
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  • [Title] Dramatic improvement of inoperable angiosarcoma with combination paclitaxel and bevacizumab chemotherapy.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Facial Neoplasms / drug therapy. Facial Neoplasms / pathology. Hemangiosarcoma / drug therapy. Hemangiosarcoma / pathology

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  • (PMID = 20846560.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 2S9ZZM9Q9V / Bevacizumab; P88XT4IS4D / Paclitaxel
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49. Di Tommaso L, Colombo G, Miceli S, Ferrari B, Santoro A, Poletti A, Roncalli M: [Angiosarcoma of the nasal cavity. Report of a case and review of the literature]. Pathologica; 2007 Jun;99(3):76-80
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  • [Title] [Angiosarcoma of the nasal cavity. Report of a case and review of the literature].
  • [Transliterated title] Angiosarcoma della cavità nasale. Descrizione di un caso e revisione della letteratura.
  • We report an unusual case of primary angiosarcoma of the nasal cavity (AS-nc).
  • Clinical--monolateral epistaxis in a young person--, radiological--polypoid hemorrhagic tumor arising within the nasal cavity and expanding into paranasal sinuses--, pathological--a network of anastomosing channels and solid areas immunoreactive for CD31 and CD34--and prognostic features--patient alive and well 36 months after the original diagnosis--are superimposable to those of previously reported AS-nc, suggesting that this lesion should be considered as a peculiar variant of classical AS.
  • [MeSH-major] Hemangiosarcoma / pathology. Nasal Cavity. Nose Neoplasms / pathology

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  • (PMID = 17987727.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 10
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50. Fine SW, Lisanti MP, Argani P, Li M: Caveolin-3 is a sensitive and specific marker for rhabdomyosarcoma. Appl Immunohistochem Mol Morphol; 2005 Sep;13(3):231-6
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  • In this study the authors evaluated the distribution of Cav-3 in normal human tissues and compared the expression of Cav-3 with that of myogenin and myoD1 in rhabdomyosarcoma (RMS), malignant mixed mullerian tumor (MMMT), and an array of neoplasms that mimic RMS to assess the utility of Cav-3 as a diagnostic marker for tumors with skeletal muscle differentiation.
  • Fifty-four other neoplasms (13 leiomyosarcomas, 8 neuroblastomas, 5 lymphomas, 6 Wilms tumors without skeletal muscle differentiation, 5 Ewing sarcomas, 4 malignant fibrous histiocytomas, 4 angiosarcomas, 6 malignant melanomas, and 3 synovial sarcomas) were negative for Cav-3 expression.

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  • (PMID = 16082247.001).
  • [ISSN] 1541-2016
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / MyoD Protein; 0 / MyoD1 myogenic differentiation protein; 0 / Myogenin
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51. Gengler C, Coindre JM, Leroux A, Trassard M, Ranchère-Vince D, Valo I, Michels JJ, Guillou L: Vascular proliferations of the skin after radiation therapy for breast cancer: clinicopathologic analysis of a series in favor of a benign process: a study from the French Sarcoma Group. Cancer; 2007 Apr 15;109(8):1584-98
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  • [Title] Vascular proliferations of the skin after radiation therapy for breast cancer: clinicopathologic analysis of a series in favor of a benign process: a study from the French Sarcoma Group.
  • BACKGROUND: Cutaneous vascular proliferations that occur in the field of prior radiotherapy include angiosarcoma and small, cutaneous lesions with a pseudosarcomatous pattern that previously were reported as atypical vascular lesions or benign lymphangiomatous papules.
  • Data from all patients were retrieved from the files of the French Sarcoma Group.
  • They were composed of dilated or irregular-jagged vascular channels that were lined by a single layer of bland endothelial cells, and they demonstrated either a predominately lymphangioendothelioma-like or lymphangioma/lymphangioma circumscriptum-like growth pattern.
  • None of the patients developed cutaneous angiosarcoma.
  • CONCLUSIONS: Although vascular proliferations in irradiated skin may mimic angiosarcoma morphologically, the large majority of these lesions showed a benign clinical outcome.


52. Pernas Simon S, Fuentes Raspall MJ, de Andrés Basauri L, Barnadas Andiñach MA: [Breast angiosarcoma after conservative treatment for breast carcinoma]. Med Clin (Barc); 2005 Apr 9;124(13):515
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  • [Title] [Breast angiosarcoma after conservative treatment for breast carcinoma].
  • [Transliterated title] Angiosarcoma de mama tras tratamiento conservador en cáncer de mama.
  • [MeSH-major] Breast Neoplasms / pathology. Hemangiosarcoma / pathology. Neoplasms, Second Primary / pathology

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  • (PMID = 15847772.001).
  • [ISSN] 0025-7753
  • [Journal-full-title] Medicina clínica
  • [ISO-abbreviation] Med Clin (Barc)
  • [Language] spa
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Antigens, CD34
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53. Dogliotti E: Molecular mechanisms of carcinogenesis by vinyl chloride. Ann Ist Super Sanita; 2006;42(2):163-9
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  • In 1974 vinyl chloride (VC), a gas used in the plastics industry, was shown to be a human carcinogen, inducing a very rare type of tumor, angiosarcoma of the liver.

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  • (PMID = 17033136.001).
  • [ISSN] 0021-2571
  • [Journal-full-title] Annali dell'Istituto superiore di sanità
  • [ISO-abbreviation] Ann. Ist. Super. Sanita
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Carcinogens; WD06X94M2D / Vinyl Chloride
  • [Number-of-references] 60
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54. Jin M, Matsumoto S, Dewa Y, Nishimura J, Saekusa Y, Hasumi K, Mitsumori K: Extremely weak tumor-promoting effect of troglitazone on splenic hemangiosarcomas in rasH2 mice induced by urethane. Arch Toxicol; 2008 Oct;82(10):771-7
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  • [Title] Extremely weak tumor-promoting effect of troglitazone on splenic hemangiosarcomas in rasH2 mice induced by urethane.
  • To examine the tumor-promoting effect of troglitazone (TRG), a novel thiazolidinedione insulin-sensitizing agent, on splenic hemangiosarcomas in rasH2 mice, histopathological and molecular analyses were performed in the spleen of female rasH2 mice fed a diet containing 6,000 or 0 ppm TRG for 16 weeks after 1,000 or 0 mg/kg urethane (UR) initiation.
  • Histopathologically, splenic hemangiosarcomas were observed in the UR-alone and UR + TRG groups, but there was no significant difference in the incidence of splenic hemangiosarcomas between the UR-alone and UR+TRG groups.
  • These results suggest that the vascular tumor-promoting activity of TRG in rasH2 mice is extremely low in the present experimental condition and a part of the gene related to angiogenesis probably contributes to the promotion of splenic hemangiosarcomas in rasH2 mice given TRG.
  • [MeSH-major] Carcinogens / toxicity. Chromans / toxicity. Hemangiosarcoma / chemically induced. Neoplasms, Experimental / chemically induced. Proto-Oncogene Proteins p21(ras) / genetics. Splenic Neoplasms / chemically induced. Thiazolidinediones / toxicity

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  • (PMID = 18465119.001).
  • [ISSN] 1432-0738
  • [Journal-full-title] Archives of toxicology
  • [ISO-abbreviation] Arch. Toxicol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Angiogenic Proteins; 0 / Carcinogens; 0 / Chromans; 0 / Thiazolidinediones; 3IN71E75Z5 / Urethane; EC 3.6.5.2 / HRAS protein, human; EC 3.6.5.2 / Proto-Oncogene Proteins p21(ras); I66ZZ0ZN0E / troglitazone
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56. Haris M, Koulaouzidis A, Chattington P: Scalp angiosarcoma with pulmonary metastases. Intern Med J; 2007 Dec;37(12):833-4
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  • [Title] Scalp angiosarcoma with pulmonary metastases.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Hemangiosarcoma / pathology. Lung Neoplasms / secondary. Scalp. Skin Neoplasms / pathology

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  • (PMID = 18028087.001).
  • [ISSN] 1445-5994
  • [Journal-full-title] Internal medicine journal
  • [ISO-abbreviation] Intern Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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57. Ganguly R, Mukherjee A: Infantile hemangioendothelioma: A case report and discussion. Pathol Res Pract; 2010 Jan 15;206(1):53-8
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  • [Title] Infantile hemangioendothelioma: A case report and discussion.
  • Infantile hepatic hamangioendothelioma type II is similar to angiosarcoma in terms of histomorphology and behavior.
  • The two jejunal masses and the hepatic lesion were diagnosed as angiosarcoma histomorphologically (IHHE type II), and were positive for vascular markers (CD31 and CD34) on immunohistochemistry.
  • [MeSH-major] Hemangioendothelioma / secondary. Jejunal Neoplasms / secondary. Liver Neoplasms / pathology

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  • [Copyright] Copyright 2009 Elsevier GmbH. All rights reserved.
  • (PMID = 19321270.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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58. Ikeda K, Maehara M, Ohmura N, Kurokawa H, Koda K, Yokoyama H, Sawada S: Spontaneous rupture of a necrotic hepatic angiosarcoma: findings on dual-phase computed tomography and angiography. Radiat Med; 2006 Jun;24(5):369-72
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  • [Title] Spontaneous rupture of a necrotic hepatic angiosarcoma: findings on dual-phase computed tomography and angiography.
  • We present dual-phase computed tomographic (CT) and angiographic findings of a ruptured hepatic angiosarcoma.
  • We found that dual-phase CT and angiographic findings are able to distinguish angiosarcoma, which mimics a hemangioma, as these lesions show avascular areas that reflect a mass with gross central necrosis.
  • [MeSH-major] Hemangiosarcoma / diagnostic imaging. Liver Neoplasms / diagnostic imaging. Tomography, X-Ray Computed / methods

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  • [Journal-full-title] Radiation medicine
  • [ISO-abbreviation] Radiat Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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59. Koutelidakis IM, Tsiaousis PZ, Papaziogas BT, Patsas AG, Atmatzidis SK, Atmatzidis KS: Spleen rupture due to primary angiosarcoma: a case report. J Gastrointest Cancer; 2007;38(2-4):74-7
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  • [Title] Spleen rupture due to primary angiosarcoma: a case report.
  • A case of a 79-year-old female with rupture of the spleen due to primary angiosarcoma is presented.
  • Diagnosis was based on histology postoperatively.
  • Primary angiosarcoma of the spleen is a very rare and aggressive neoplasm with a high metastatic rate and almost uniformly fatal.
  • [MeSH-major] Hemangiosarcoma / complications. Splenic Neoplasms / complications. Splenic Rupture / etiology

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  • (PMID = 19016352.001).
  • [ISSN] 1941-6628
  • [Journal-full-title] Journal of gastrointestinal cancer
  • [ISO-abbreviation] J Gastrointest Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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60. Welsh SJ, Khan S: Radiological localizing techniques in adrenal tumors. Minerva Endocrinol; 2009 Jun;34(2):161-9
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  • Unfortunately, there may be significant overlap between the imaging appearances of benign lesions such as lipid-poor adenomas and malignant lesions, particularly metastases and small adrenal carcinomas.
  • This review highlights recent advances in radiological imaging of adrenal lesions and we discuss the relative merits of CT and magnetic resonance imaging to aid the identification of benign and malignant adrenal lesions and their roles, in combination with biochemical and clinical data, in recognizing common pathologies such as adrenal adenoma, phaeochromocytoma, carcinoma and metastases.
  • We also discuss the radiological characteristics of rarer adrenal lesions including lymphoma, neuroblastic tumours (neuroblastoma, ganglioneuroblastoma, and ganglioneuroma), lipomatous tumours (myelolipoma, angiolipoma, teratoma, lipoma and liposarcoma), in addition to hemangioma, hemangiosarcoma and leiomyosarcoma.
  • [MeSH-minor] Adrenal Cortex Neoplasms / radiography. Adrenocortical Adenoma / radiography. Adrenocortical Carcinoma / radiography. Diagnosis, Differential. Ganglioneuroblastoma / radiography. Ganglioneuroma / radiography. Humans. Lymphoma / radiography. Magnetic Resonance Imaging. Neoplasm Metastasis. Neoplasms, Adipose Tissue / radiography. Neoplasms, Vascular Tissue / radiography. Neuroblastoma / radiography. Pheochromocytoma / radiography. Predictive Value of Tests. Sensitivity and Specificity. Teratoma / radiography

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  • (PMID = 19471240.001).
  • [ISSN] 0391-1977
  • [Journal-full-title] Minerva endocrinologica
  • [ISO-abbreviation] Minerva Endocrinol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 42
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61. McCartney E, Valluri S, Rushing D, Burgett R: Upper and lower system nasolacrimal duct stenosis secondary to paclitaxel. Ophthal Plast Reconstr Surg; 2007 Mar-Apr;23(2):170-1
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  • A 66-year-old man underwent chemotherapy and radiation for angiosarcoma of the head and neck.
  • [MeSH-minor] Aged. Combined Modality Therapy. Head and Neck Neoplasms / drug therapy. Head and Neck Neoplasms / radiotherapy. Hemangiosarcoma / drug therapy. Hemangiosarcoma / radiotherapy. Humans. Male

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  • [CommentIn] Ophthal Plast Reconstr Surg. 2009 Sep-Oct;25(5):418-9; author reply 419 [19966671.001]
  • (PMID = 17413646.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Tubulin Modulators; P88XT4IS4D / Paclitaxel
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62. Falleiro J, Singh P, Bhattacharya P, Kaushish R, Tutakne N: Angiosarcoma Presenting as Pleuro-pericardial Effusion. Med J Armed Forces India; 2006 Jan;62(1):75-6
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  • [Title] Angiosarcoma Presenting as Pleuro-pericardial Effusion.

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  • (PMID = 27407853.001).
  • [ISSN] 0377-1237
  • [Journal-full-title] Medical journal, Armed Forces India
  • [ISO-abbreviation] Med J Armed Forces India
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC4923307
  • [Keywords] NOTNLM ; Angiosarcoma / Pericardial effusion / Pleural effusion
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63. Ravi V, Benjamin RS: Systemic therapy for cardiac sarcomas. Methodist Debakey Cardiovasc J; 2010 Jul-Sep;6(3):57-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Systemic therapy for cardiac sarcomas.
  • Cardiac sarcomas create 2 risks: local problems and metastatic disease.
  • Most frequently, the histologies are angiosarcoma and high-grade pleomorphic unclassified sarcoma (formerly called MFH or malignant fibrous histiocytoma).
  • There is also a clinical-pathological entity without distinctive histological features of tumors that originate in the pulmonary artery and are referred to as pulmonary artery sarcomas or intimal sarcomas of the pulmonary artery.
  • Conventional wisdom indicates that soft-tissue sarcomas are poorly responsive to chemotherapy.
  • Attempts to concentrate on the local problem only with therapies up to and including cardiac transplantation have been unsuccessful due to the high rate of fatal metastatic disease.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Heart Neoplasms / drug therapy. Sarcoma / drug therapy

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  • (PMID = 20834213.001).
  • [ISSN] 1947-6094
  • [Journal-full-title] Methodist DeBakey cardiovascular journal
  • [ISO-abbreviation] Methodist Debakey Cardiovasc J
  • [Language] eng
  • [Publication-type] Journal Article; Portraits
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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64. Kajo K, Macháleková K, Pauer M: [Retiform hemangioendotelioma in a 8-year-old girl--case report]. Cesk Patol; 2009 Jul;45(3):72-4
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  • [Title] [Retiform hemangioendotelioma in a 8-year-old girl--case report].
  • Retiform hemangioendothelioma (RHE) is a rare vascular tumoriform lesion characterized by rete testis--like vascular structures.
  • RHE belongs to a group of vascular tumors of intermediate malignancy and together with Dabska tumor form a category of so-called hobnail hemangioendotheliomas.
  • Histologically, the tumor consisted of a net of vessel formations with retiform appearance and prominent endothelial nuclei.
  • Other benign and malignant vascular lesions with hobnail cells (hemangioma, angiosarcoma) have to be considered in differential diagnosis.
  • [MeSH-major] Hemangioendothelioma / pathology. Vascular Neoplasms / pathology

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  • (PMID = 19764161.001).
  • [ISSN] 1210-7875
  • [Journal-full-title] Československá patologie
  • [ISO-abbreviation] Cesk Patol
  • [Language] slo
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Czech Republic
  • [Chemical-registry-number] 0 / Lewis Blood-Group System
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65. Yamada M, Hatta N, Mizuno M, Oishi N, Takehara K: Weekly low-dose docetaxel in the treatment of lung metastases from angiosarcoma of the head. Br J Dermatol; 2005 Apr;152(4):811-2
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  • [Title] Weekly low-dose docetaxel in the treatment of lung metastases from angiosarcoma of the head.
  • [MeSH-major] Antineoplastic Agents, Phytogenic / administration & dosage. Head and Neck Neoplasms. Hemangiosarcoma / drug therapy. Lung Neoplasms / drug therapy. Taxoids / administration & dosage

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  • (PMID = 15840125.001).
  • [ISSN] 0007-0963
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; 0 / Taxoids; 15H5577CQD / docetaxel
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66. Namysłowski G, Scierski W, Turecka L, Urbaniec N, Lange D: [A very rare case of low-grade angiosarcoma of the nose and paranasal sinuses]. Otolaryngol Pol; 2005;59(1):105-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A very rare case of low-grade angiosarcoma of the nose and paranasal sinuses].
  • Angiosarcomas of the nose and paranasal sinuses are extremely rare.
  • Histologically angiosarcomas are divided into two groups: low and high-grade.
  • We present a case of angiosarcoma of apparent low-grade malignancy localized within the nasal cavity and paranasal sinuses in a 74-year old woman treated by radiotherapy due to middle ear chemodectoma 21 years ago.
  • [MeSH-major] Hemangiosarcoma. Nose Neoplasms. Paranasal Sinus Neoplasms

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  • (PMID = 15915928.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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67. Kalitova P, Plzak J, Kodet R, Astl J: Angiosarcoma of the thyroid. Eur Arch Otorhinolaryngol; 2009 Jun;266(6):903-5
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  • [Title] Angiosarcoma of the thyroid.
  • Hemangiosarcoma of the thyroid gland is a very rare entity.
  • The histological diagnosis of thyroid hemangiosarcoma is mostly difficult.
  • [MeSH-major] Hemangiosarcoma / surgery. Thyroid Neoplasms / surgery. Thyroidectomy / methods

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  • [Cites] Endocr J. 2005 Feb;52(1):57-9 [15758558.001]
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  • (PMID = 18941766.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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68. Defawe OD, Thiry A, Lapiere CM, Limet R, Sakalihasan N: Primary sarcoma of an abdominal aortic aneurysm. Abdom Imaging; 2006 Jan-Feb;31(1):117-9
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  • [Title] Primary sarcoma of an abdominal aortic aneurysm.
  • Primary tumors of the aorta are extremely rare and the diagnosis is made most often after surgery or autopsy.
  • Because clinical symptoms of abdominal sarcoma are similar to those of occlusive or aneurysmal disease, aortic sarcomas are frequently mistaken for these lesions.
  • The imaging findings are frequently nonspecific and therefore do not allow a definitive preoperative diagnosis.
  • We report a case of an epithelioid angiosarcoma in the vessel wall of an abdominal aortic aneurysm.
  • [MeSH-major] Aortic Aneurysm, Abdominal / complications. Aortic Diseases / complications. Hemangiosarcoma / complications. Vascular Neoplasms / complications

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  • (PMID = 16314988.001).
  • [ISSN] 0942-8925
  • [Journal-full-title] Abdominal imaging
  • [ISO-abbreviation] Abdom Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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69. Kasper DA, Smetanick MT, Ermolovich T: Angiosarcoma clinically resembling morpheaform basal cell carcinoma. Dermatol Surg; 2008 Oct;34(10):1407-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma clinically resembling morpheaform basal cell carcinoma.
  • [MeSH-major] Carcinoma, Basal Cell / diagnosis. Hemangiosarcoma / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. Face. Female. Humans. Skin Ulcer / diagnosis

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  • (PMID = 18637812.001).
  • [ISSN] 1524-4725
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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70. Hoti E, Adam R: Liver transplantation for primary and metastatic liver cancers. Transpl Int; 2008 Dec;21(12):1107-17
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  • Liver resection may offer similar survival results to orthotopic liver transplantation (OLT) in the short term, and does not carry the long-term effects of immunosuppression; however, long-term and disease-free survival favours liver transplantation.
  • Survival rate in these selected patients can approach that of patients with cholestatic liver disease, and the role of transplantation now requires re-evaluation.
  • Epithelioid hemangioendothelioma is also an appropriate indication for liver transplantation, even in the presence of extrahepatic metastases, unlike angiosarcoma which is associated with a very poor survival and considered as a contraindication.
  • And finally for metastatic liver disease from neuroendocrine tumours, liver transplantation can result in long-term survival and even cure in well selected patients.
  • [MeSH-minor] Bile Duct Neoplasms / surgery. Carcinoma, Hepatocellular / pathology. Carcinoma, Hepatocellular / surgery. Cholangiocarcinoma / surgery. Colorectal Neoplasms / pathology. Hemangioendothelioma / surgery. Hemangiosarcoma / surgery. Humans. Neoplasm Metastasis. Neoplasm Staging. Neuroendocrine Tumors / surgery. Survival Analysis. Survivors. Treatment Outcome

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  • (PMID = 18713148.001).
  • [ISSN] 0934-0874
  • [Journal-full-title] Transplant international : official journal of the European Society for Organ Transplantation
  • [ISO-abbreviation] Transpl. Int.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 75
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71. Kopp HG, Kanz L, Hartmann JT: Complete remission of relapsing high-grade angiosarcoma with single-agent metronomic trofosfamide. Anticancer Drugs; 2006 Sep;17(8):997-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Complete remission of relapsing high-grade angiosarcoma with single-agent metronomic trofosfamide.
  • A limited repertoire of chemotherapeutics is available for the therapy of metastasizing angiosarcoma.
  • We report on a case from our clinic, in which a complete response with oral trofosfamide was achieved in a patient suffering from relapsed high-grade angiosarcoma metastasizing to the liver and lung.
  • Responses like this are encouraging and should make us rethink treatment approaches for metastasizing soft-tissue sarcoma.
  • [MeSH-major] Antineoplastic Agents, Alkylating / therapeutic use. Cyclophosphamide / analogs & derivatives. Hemangiosarcoma / drug therapy. Neoplasm Recurrence, Local / drug therapy

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  • (PMID = 16940811.001).
  • [ISSN] 0959-4973
  • [Journal-full-title] Anti-cancer drugs
  • [ISO-abbreviation] Anticancer Drugs
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 8N3DW7272P / Cyclophosphamide; H64JRU6GJ0 / trofosfamide
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72. Suzuki H, Komatsu A, Fujioka Y, Yamashiro K, Takeda H, Hamada T: Angiosarcoma-like metastatic carcinoma of the liver. Pathol Res Pract; 2010 Jul 15;206(7):484-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma-like metastatic carcinoma of the liver.
  • Two cases of metastatic carcinoma strikingly simulating angiosarcoma in the liver are described.
  • Both cases had an angiosarcoma-like appearance macroscopically and microscopically.
  • Immunohistochemically, the tumor cells of both cases were negative for CD31, CD34, and Factor VIII-related antigen and positive for several types of cytokeratin, suggesting that they were not angiosarcomas but carcinomas.
  • Angiosarcoma is the most common sarcoma arising in the liver.
  • Thus, metastatic carcinoma, which resembles angiosarcoma, might be mistaken for angiosarcoma.
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. Female. Hemangiosarcoma / pathology. Humans. Immunohistochemistry. Middle Aged

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  • [Copyright] Copyright 2009 Elsevier GmbH. All rights reserved.
  • (PMID = 20097483.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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73. Kaddu S, Wolf I, Horn M, Kerl H: Epithelioid sarcoma with angiomatoid features: report of an unusual case arising in an elderly patient within a burn scar. J Cutan Pathol; 2008 Mar;35(3):324-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epithelioid sarcoma with angiomatoid features: report of an unusual case arising in an elderly patient within a burn scar.
  • Epithelioid sarcoma (ES) is a rare, aggressive soft tissue tumor with a characteristic predilection for adolescents and young adults, and a tendency to occur on distal extremities.
  • The overall histopathologic features were consistent with a diagnosis of ES.
  • In this uncommon setting, this tumor should be especially distinguished from epithelioid hemangioendothelioma and epithelioid angiosarcoma.
  • [MeSH-major] Angiomatosis / pathology. Burns / pathology. Cicatrix / pathology. Sarcoma / pathology. Soft Tissue Neoplasms / pathology


74. Eriksson M: Histology-driven chemotherapy of soft-tissue sarcoma. Ann Oncol; 2010 Oct;21 Suppl 7:vii270-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Histology-driven chemotherapy of soft-tissue sarcoma.
  • Soft-tissue sarcomas are rare diseases with >50 subtypes.
  • Surgery is the most important treatment in localized disease, sometimes combined with radiotherapy.
  • Chemotherapy is used as palliation in advanced disease, sometimes also with a potential to decrease tumour size and eradicate micro-metastases, making meaningful surgery possible.
  • The role of chemotherapy as adjuvant treatment in localized disease is not finally settled.
  • Doxorubicin and ifosfamide are the two drugs with the best established response rates in soft-tissue sarcoma, and a combination of these drugs has been a 'gold standard' for several years.
  • Examples are trabectedin in lyposarcoma and leiomyosarcoma, and taxanes in angiosarcoma.

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  • (PMID = 20943627.001).
  • [ISSN] 1569-8041
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
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75. Méndez-Sánchez N, Roldán-Valadéz E, Motola-Kuba D, Almeda-Valdés P, Uribe M: Hepatic angiosarcoma. Ann Hepatol; 2005 Jan-Mar;4(1):60-1
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hepatic angiosarcoma.
  • [MeSH-major] Hemangiosarcoma / diagnosis. Liver Neoplasms / diagnosis

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  • (PMID = 15798664.001).
  • [ISSN] 1665-2681
  • [Journal-full-title] Annals of hepatology
  • [ISO-abbreviation] Ann Hepatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Mexico
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76. Leggio L: Primary angiosarcoma of the kidney: size is the main prognostic factor. Int J Urol; 2007 Aug;14(8):777; author reply 777-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary angiosarcoma of the kidney: size is the main prognostic factor.
  • [MeSH-major] Hemangiosarcoma / pathology. Hemangiosarcoma / surgery. Kidney Neoplasms / pathology. Kidney Neoplasms / surgery

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  • [CommentOn] Int J Urol. 2006 Aug;13(8):1112-4 [16903939.001]
  • (PMID = 17681076.001).
  • [ISSN] 0919-8172
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Comment; Letter
  • [Publication-country] Australia
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77. Newell-Fugate A, Lane E: Periaortic haemangiosarcoma in an African wild dog (Lycaon pictus). J S Afr Vet Assoc; 2009 Jun;80(2):108-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Periaortic haemangiosarcoma in an African wild dog (Lycaon pictus).
  • Histologically, the mass was consistent with a haemangiosarcoma.
  • [MeSH-major] Canidae. Heart Neoplasms / veterinary. Hemangiosarcoma / veterinary

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  • (PMID = 19831274.001).
  • [ISSN] 1019-9128
  • [Journal-full-title] Journal of the South African Veterinary Association
  • [ISO-abbreviation] J S Afr Vet Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] South Africa
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78. Cardinale L, Mirra M, Galli C, Goldblum JR, Pizzolitto S, Falconieri G: Angiosarcoma of the uterus: report of 2 new cases with deviant clinicopathologic features and review of the literature. Ann Diagn Pathol; 2008 Jun;12(3):217-21
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  • [Title] Angiosarcoma of the uterus: report of 2 new cases with deviant clinicopathologic features and review of the literature.
  • A few cases of uterine angiosarcoma have been detailed in the literature: 2 new cases are herein described featuring some unusual clinical or phenotypic differences compared with previously published cases, such as occurrence in premenopausal age or a poorly differentiated histology.
  • In one case, the neoplastic growth deceitfully recalled a poorly differentiated leiomyosarcoma showing focal rudimentary endothelial differentiation.
  • One patient died shortly during the follow-up, whereas the other is alive with evidence of disseminated disease.
  • Occurrence in childbearing age or a deviant histologic pattern, as documented in this report, may be added to the clinicopathologic spectrum of uterine angiosarcoma.
  • [MeSH-major] Hemangiosarcoma / secondary. Uterine Neoplasms / pathology
  • [MeSH-minor] Adult. Aged, 80 and over. Antigens, CD / analysis. Biomarkers, Tumor / analysis. Diagnosis, Differential. Factor VIII / analysis. Fatal Outcome. Female. Humans. Immunohistochemistry. Leiomyosarcoma / diagnosis. Necrosis

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  • (PMID = 18486900.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Biomarkers, Tumor; 9001-27-8 / Factor VIII
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79. Roblin P, Ross DA: Use of the vertical rectus abdominis myocutaneous flap after abdominoplasty. Br J Plast Surg; 2005 Sep;58(6):838-40
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  • A vertical rectus abdominis myocutaneous flap was used to provide cover for a recurrent angiosarcoma in the abdominal skin.
  • [MeSH-major] Abdominal Neoplasms / surgery. Hemangiosarcoma / surgery. Rectus Abdominis / transplantation. Skin Neoplasms / surgery. Surgical Flaps

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  • (PMID = 16086991.001).
  • [ISSN] 0007-1226
  • [Journal-full-title] British journal of plastic surgery
  • [ISO-abbreviation] Br J Plast Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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80. Halkes CJ, Dijstelbloem HM, Eelkman Rooda SJ, Kramer MH: Extreme leucocytosis: not always leukaemia. Neth J Med; 2007 Jul-Aug;65(7):248-51
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  • This reaction was associated with a hepatic angiosarcoma in the first patient, with a Salmonella infection in the second patient and with a necrotic leg abscess in the third patient.
  • [MeSH-major] Leukemoid Reaction / etiology. Leukocytosis / diagnosis. Leukocytosis / etiology. Paraneoplastic Syndromes
  • [MeSH-minor] Abscess / complications. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Hemangiosarcoma / complications. Humans. Leg / physiopathology. Leukemia. Liver / physiopathology. Male. Salmonella Infections / complications

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  • (PMID = 17656811.001).
  • [ISSN] 0300-2977
  • [Journal-full-title] The Netherlands journal of medicine
  • [ISO-abbreviation] Neth J Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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81. Li L, Wang HY, Zhao H, Ruan YM, Lü FY, Wang QZ, Meng Y, Liu L: [Clinicopathologic studies of 11 cases of primary cardiac valve tumors]. Zhonghua Bing Li Xue Za Zhi; 2006 Mar;35(3):142-4
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  • The tumor subtypes included papillary fibroelastoma (4/11), cavernous hemangioma (4/11), glomus tumor (1/11), angiosarcoma (1/11) and hamartoma (1/11).
  • The diagnosis was established by preoperative echocardiography in 7 patients.
  • CONCLUSIONS: Preoperative diagnosis of primary cardiac valve tumors can be difficult due to lack of detailed information related to this group of lesions.

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  • (PMID = 16630501.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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82. Cheshier SH, Bababeygy SR, Higgins D, Parsonnet J, Huhn SL: Cerebral myiasis associated with angiosarcoma of the scalp: case report. Neurosurgery; 2007 Jul;61(1):E167; discussion E167
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cerebral myiasis associated with angiosarcoma of the scalp: case report.
  • Biopsy of the scalp and cranium revealed angiosarcoma, for which operative treatment was refused.
  • [MeSH-major] Brain Diseases / parasitology. Brain Diseases / therapy. Myiasis / diagnosis. Myiasis / parasitology. Myiasis / therapy. Scalp / parasitology. Skin Neoplasms / parasitology

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  • (PMID = 17621006.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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83. Moses KA, Tillett JW, Master VA: Primary penile angiosarcoma in a patient with AIDS: a case report. AIDS; 2007 Nov 12;21(17):2355-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary penile angiosarcoma in a patient with AIDS: a case report.
  • [MeSH-major] Acquired Immunodeficiency Syndrome / complications. Hemangiosarcoma / virology. Penile Neoplasms / virology
  • [MeSH-minor] Adult. Humans. Male. Sarcoma, Kaposi / complications

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  • (PMID = 18090289.001).
  • [ISSN] 0269-9370
  • [Journal-full-title] AIDS (London, England)
  • [ISO-abbreviation] AIDS
  • [Language] eng
  • [Publication-type] Case Reports; Letter; Review
  • [Publication-country] England
  • [Number-of-references] 11
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84. Dow N, Giblen G, Sobin LH, Miettinen M: Gastrointestinal stromal tumors: differential diagnosis. Semin Diagn Pathol; 2006 May;23(2):111-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gastrointestinal stromal tumors: differential diagnosis.
  • Availability of KIT tyrosine kinase inhibitors for specific treatment of GISTs has magnified the importance of accurate differential diagnosis of GIST from other tumors occurring in the GI tract and abdomen.
  • The identification of these tumors as GISTs is based on knowledge of the spectrum of GIST morphology, and can be supported by molecular diagnosis of KIT and PDGFRA mutations (the latter pertain to gastric tumors).
  • GI schwannomas, melanoma, and rare primary clear cell sarcoma are S100-positive, usually with characteristic histology.
  • KIT-positive non-GISTs include some sarcomas, especially angiosarcoma and Ewing sarcoma, extramedullary myeloid tumor, seminoma, and a few carcinomas, notably small cell carcinoma of lung.
  • Spurious KIT-positivity, seen with some polyclonal KIT antibodies, has been a source of confusion leading to probable false-positive results in fibroblastic tumors and occasional other sarcomas, such as leiomyosarcomas.
  • Integration of histological features with carefully standardized immunohistochemistry, supported by KIT and PDGFRA mutation analysis, is the cornerstone of state-of-the art differential diagnosis of GIST.
  • [MeSH-major] Gastrointestinal Stromal Tumors / diagnosis. Proto-Oncogene Proteins c-kit / metabolism
  • [MeSH-minor] Diagnosis, Differential. Humans. Immunohistochemistry. Neoplasms, Connective and Soft Tissue / diagnosis

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  • (PMID = 17193824.001).
  • [ISSN] 0740-2570
  • [Journal-full-title] Seminars in diagnostic pathology
  • [ISO-abbreviation] Semin Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
  • [Number-of-references] 67
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85. Deyrup AT, Tighiouart M, Montag AG, Weiss SW: Epithelioid hemangioendothelioma of soft tissue: a proposal for risk stratification based on 49 cases. Am J Surg Pathol; 2008 Jun;32(6):924-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epithelioid hemangioendothelioma of soft tissue: a proposal for risk stratification based on 49 cases.
  • Epithelioid hemangioendothelioma (EHE) of soft tissue is a distinctive vascular tumor that has been variously considered a tumor of borderline malignancy and low-grade angiosarcoma.
  • For actuarial analysis, disease-specific overall survival was evaluated using univariate and multivariable analysis.
  • Clinical follow-up was obtained for all patients and ranged from 1.5 to 170 months (mean, 57.9 mo); 31 patients were alive without disease, 5 patients were alive with disease, 9 patients died of disease and 4 died of other causes.
  • Overall 5-year disease-specific survival was 81%.
  • Eleven patients (22%) had metastatic disease affecting lung (6), lymph node (4), liver (2), and bone, retroperitoneum, and soft tissue (1 each).
  • Patients with high-risk tumors had a 5-year disease-specific survival of 59%; no patients with low-risk tumors died.
  • [MeSH-major] Hemangioendothelioma, Epithelioid / diagnosis. Soft Tissue Neoplasms / diagnosis

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  • (PMID = 18551749.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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86. Di Matteo FM, De Stefano M, Vanni B, Palermo S, Biancafarina A, Giusti D, Savino G, Di Marco C, Casalvieri L, De Antoni E: [Retroperitoneal giant mixed sarcoma. Case report]. G Chir; 2008 May;29(5):238-41
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  • [Title] [Retroperitoneal giant mixed sarcoma. Case report].
  • [Transliterated title] Un caso di sarcoma misto retroperitoneale gigante.
  • Histology showed a mixed liposarcoma and angiosarcoma with high grade of malignancy and positivity for vimentin, factor VIII, CD34, CD31 and negativity for S-100, CD68, AMS, AML.
  • [MeSH-major] Hemangiosarcoma / surgery. Liposarcoma / surgery. Neoplasms, Multiple Primary / surgery. Retroperitoneal Neoplasms / surgery

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  • (PMID = 18507961.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
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87. Saitou M, Niitsuma K: [A case of pyothorax-associated pleural angiosarcoma diagnosed by autopsy]. Kekkaku; 2009 Jul;84(7):531-4
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  • [Title] [A case of pyothorax-associated pleural angiosarcoma diagnosed by autopsy].
  • Neither CT nor sonographically guided fine needle biopsies and cytological examinations were helpful in diagnosing this disease.
  • Finally, the diagnosis was made of pyothorax-associated pleural Angiosarcoma.
  • Angiosarcoma is rare and difficult to diagnosis, however, we have to keep in mind the presence of disease pyothorax-associated pleural angiosarcoma.
  • [MeSH-major] Empyema, Pleural / complications. Hemangiosarcoma / etiology. Pleural Neoplasms / etiology

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  • (PMID = 19670800.001).
  • [ISSN] 0022-9776
  • [Journal-full-title] Kekkaku : [Tuberculosis]
  • [ISO-abbreviation] Kekkaku
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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88. Takeuchi T, Iwasaki S, Miyazaki J, Nozaki Y, Takahashi M, Ono M, Saibara T, Furihata M: Matrix metalloproteinase-1 expression in splenic angiosarcoma metastasizing to the serous membrane. Int J Clin Exp Pathol; 2010;3(6):634-9
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  • [Title] Matrix metalloproteinase-1 expression in splenic angiosarcoma metastasizing to the serous membrane.
  • Angiosarcoma involving the serous membrane may mimic mesothelioma; therefore, the term "pseudomesotheliomatous angiosarcoma" has been suggested for this entity.
  • However, the pathogenesis of pseudomesotheliomatous angiosarcoma remains unclear.
  • Here, we report an autopsy case of splenic angiosarcoma, which systemically metastasized to the serous membrane of both the peritoneum and pleura, closely resembling a mesothelioma.
  • In the present case, immunohistochemical staining showed that the tumor expressed not only the endothelial cell markers, such as CD31, vascular endothelial growth factor receptor 3, and podoplanin (D2-40), but also matrix metalloproteinase-1 (also known as collagenase-1), which is known to increase the invasiveness of mesothelioma cells.
  • MMP-1 expression was not observed in the other cases of angiosarcoma, examined.
  • [MeSH-major] Hemangiosarcoma / enzymology. Matrix Metalloproteinase 1 / biosynthesis. Peritoneal Neoplasms / secondary. Pleural Neoplasms / secondary. Splenic Neoplasms / enzymology

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  • (PMID = 20661412.001).
  • [ISSN] 1936-2625
  • [Journal-full-title] International journal of clinical and experimental pathology
  • [ISO-abbreviation] Int J Clin Exp Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 3.4.24.7 / Matrix Metalloproteinase 1
  • [Other-IDs] NLM/ PMC2907126
  • [Keywords] NOTNLM ; Angiosarcoma / MMP-1 / collagenase-1 / pseudomesothelioma
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89. Yang WT, Hennessy BT, Dryden MJ, Valero V, Hunt KK, Krishnamurthy S: Mammary angiosarcomas: imaging findings in 24 patients. Radiology; 2007 Mar;242(3):725-34
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  • [Title] Mammary angiosarcomas: imaging findings in 24 patients.
  • PURPOSE: To retrospectively evaluate the clinical, imaging, and pathologic findings of mammary angiosarcomas in 24 patients.
  • Twenty-four patients with records in the surgical pathology database who had a diagnosis of mammary angiosarcoma (n = 26) and who underwent preoperative imaging with mammography, ultrasonography (US), or magnetic resonance (MR) imaging were included.
  • Mean and median ages at time of diagnosis were 40 and 38 years, respectively (range, 15-77 years).
  • Total length of follow-up (in months) was determined by the interval from the time of diagnosis to the time of last follow-up.
  • Information on overall and disease-free survival was also obtained.
  • RESULTS: Mean tumor size at time of diagnosis was 5.9 cm (range, 1-12 cm).
  • Mammograms of 16 tumors showed a noncalcified mass in eight, focal asymmetry in five, and no abnormality in three.
  • Dynamic contrast material-enhanced MR imaging of nine tumors showed large, lobular, and intensely and heterogeneously enhancing masses with rapid enhancement and the washout characteristics of a malignant lesion.
  • CONCLUSION: A mass that shows homogeneous or heterogeneous hyperechogenicity at US (with associated architectural distortion) and has a hypervascular, hemorrhagic, and heterogeneous appearance and typical malignant enhancement characteristics at MR imaging should alert the radiologist to a possible diagnosis of angiosarcoma.
  • [MeSH-major] Breast Neoplasms / diagnosis. Hemangiosarcoma / diagnosis. Magnetic Resonance Imaging / methods. Ultrasonography, Mammary / methods

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  • (PMID = 17325063.001).
  • [ISSN] 0033-8419
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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90. Al Dhaybi R, Powell J, McCuaig C, Kokta V: Differentiation of vascular tumors from vascular malformations by expression of Wilms tumor 1 gene: evaluation of 126 cases. J Am Acad Dermatol; 2010 Dec;63(6):1052-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Based on the International Society for the Study of Vascular Anomalies classification of vascular anomalies, we studied the expression of WT1 in vascular tumors composed of infantile hemangioma, congenital hemangiomas (non-involuting, rapidly involuting, and not otherwise specified), pyogenic granuloma, tufted angioma, cherry angioma, Kaposi sarcoma, and angiosarcoma.
  • RESULTS: All vascular tumors and proliferations had positive WT1 cytoplasmic endothelial immunostaining whereas only 3 vascular malformations were WT1 positive.
  • LIMITATIONS: The low number of malignant vascular tumors is a limitation.
  • [MeSH-minor] Adolescent. Adult. Aged. Biopsy. Cell Division / physiology. Child. Child, Preschool. Cytoplasm / metabolism. Diagnosis, Differential. Humans. Immunohistochemistry. Infant. Infant, Newborn. Middle Aged. Young Adult


91. Ramjee V, Ellozy S: Aortic angiosarcoma masquerading as a thoracic aortic aneurysm. J Vasc Surg; 2009 Dec;50(6):1477-80
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  • [Title] Aortic angiosarcoma masquerading as a thoracic aortic aneurysm.
  • Aortic angiosarcoma is an exceedingly rare clinical entity.
  • Significant delay in diagnosis can occur due to a low index of suspicion on the part of the clinician.
  • We report a case of aortic angiosarcoma masquerading as a descending thoracic aneurysm arising from a penetrating ulcer.
  • FDG-PET CT scan and biopsy ultimately confirmed the diagnosis of aortic angiosarcoma.
  • This case highlights some of the difficulties of making the early diagnosis of aortic angiosarcoma.
  • [MeSH-major] Aorta / pathology. Aortic Aneurysm, Thoracic / diagnosis. Diagnostic Errors. Hemangiosarcoma / diagnosis. Vascular Neoplasms / diagnosis

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  • (PMID = 19703752.001).
  • [ISSN] 1097-6809
  • [Journal-full-title] Journal of vascular surgery
  • [ISO-abbreviation] J. Vasc. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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92. Pradhan S, Bazan H, Salem R, Gusberg RJ: Intravenous lobular capillary hemangioma originating in the iliac veins: a case report. J Vasc Surg; 2008 Jun;47(6):1346-9
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  • Intravenous lobular capillary hemangioma is a rare benign lesion that can mimic other intravascular lesions encountered by vascular surgeons, such as angiosarcoma, papillary endothelial hyperplasia, and deep vein thrombus.
  • Diagnosis of these lesions can be difficult.
  • We describe the utility of duplex ultrasound and magnetic resonance venography in aiding preoperative diagnosis and surgical planning.
  • The diagnosis is ultimately confirmed with histology that demonstrates multiple capillaries lined with flattened endothelial cells grouped in a lobular fashion admixed with fibromyxoid stroma containing collagenous fibers, spindle cells, and mitotic figures.
  • Treatment should be with resection and specimen processing to rule-out malignant vascular tumors.
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Magnetic Resonance Angiography. Phlebography. Tomography, X-Ray Computed. Ultrasonography, Doppler, Duplex. Vascular Neoplasms / pathology. Vascular Surgical Procedures. Venous Thrombosis / pathology


93. Körner M, Waser B, Reubi JC: High expression of neuropeptide Y1 receptors in ewing sarcoma tumors. Clin Cancer Res; 2008 Aug 15;14(16):5043-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] High expression of neuropeptide Y1 receptors in ewing sarcoma tumors.
  • Because NPY receptors are expressed in selected sarcoma cell lines and because novel treatment options are needed for sarcomas, this study assessed the NPY receptor in primary human sarcomas.
  • EXPERIMENTAL DESIGN: Tumor tissues of 88 cases, including Ewing sarcoma family of tumors (ESFT), synovial sarcomas, osteosarcomas, chondrosarcomas, liposarcomas, angiosarcomas, rhabdomyosarcomas, leiomyosarcomas, and desmoid tumors, were investigated for NPY receptor protein with in vitro receptor autoradiography using (125)I-labeled NPY receptor ligands and for NPY receptor mRNA expression with in situ hybridization.
  • Likewise, synovial sarcomas expressed Y1 on tumor cells in high density (mean, 7,497 dpm/mg; incidence, 40%).
  • Moreover, many of the sarcomas showed Y1 expression on intratumoral blood vessels.
  • CONCLUSIONS: NPY receptors are novel molecular markers for human sarcomas.
  • Y1 may inhibit growth of specific sarcomas, as previously shown in an in vivo mouse model of human ESFT.
  • The high Y1 expression on tumor cells of ESFT and synovial sarcomas and on blood vessels in many other sarcomas represents an attractive basis for an in vivo tumor targeting.
  • [MeSH-major] Biomarkers, Tumor / analysis. Bone Neoplasms / metabolism. Receptors, Neuropeptide Y / biosynthesis. Sarcoma, Ewing / metabolism
  • [MeSH-minor] Arteries / metabolism. Autoradiography. Gene Expression. Humans. In Situ Hybridization. RNA, Messenger / analysis. Sarcoma / blood supply. Sarcoma / metabolism. Soft Tissue Neoplasms / blood supply. Soft Tissue Neoplasms / metabolism

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  • (PMID = 18698022.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / RNA, Messenger; 0 / Receptors, Neuropeptide Y; 0 / neuropeptide Y-Y1 receptor
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94. Rüsseler AV, Brors B, Fischer T, Hartmann JT, Hartmann W, Hohenberger P, Lichter P, Marx A, Mechtersheimer G, Penzel R, Renner M, Schildhaus HU, Schirmacher P, Sievers E, Ströbel P, Wardelmann E, Ziesché E, Büttner R: [Molecular pathology of sarcomas. Update on the research group "Molecular Diagnosis of Sarcomas"]. Pathologe; 2010 Oct;31 Suppl 2:211-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Molecular pathology of sarcomas. Update on the research group "Molecular Diagnosis of Sarcomas"].
  • To establish precise diagnostic algorithms and standardised treatment of sarcomas in specialized centers, the interdisciplinary research group KoSar (sarcoma competence network) has been funded by German Cancer Aid.
  • A sarcoma tissue repository and a diagnostic reference center have been set up, presently containing about 1000 accurately diagnosed sarcomas of different entities.
  • Significant gene expression profiles for synovial sarcomas, leiomyosarcomas, myxoid liposarcomas and a small profile for myxofibrosarcomas as well as a new classification of angiosarcomas were defined.
  • We systematically searched for activated signal transduction pathways in sarcoma cell lines and xenograft transplant models and candidate targets for molecular therapies were identified.
  • Based on these results first clinical studies have been initiated by the German Interdisciplinary Sarcoma Study Group (GISG).
  • [MeSH-major] Sarcoma / genetics. Sarcoma / pathology
  • [MeSH-minor] Animals. Biomedical Research. Cell Line, Tumor. Cooperative Behavior. Drug Evaluation, Preclinical. Fibrosarcoma / diagnosis. Fibrosarcoma / drug therapy. Fibrosarcoma / genetics. Fibrosarcoma / pathology. Gene Expression Profiling. Gene Expression Regulation, Neoplastic / genetics. Humans. Interdisciplinary Communication. Leiomyosarcoma / diagnosis. Leiomyosarcoma / drug therapy. Leiomyosarcoma / genetics. Leiomyosarcoma / pathology. Liposarcoma, Myxoid / diagnosis. Liposarcoma, Myxoid / drug therapy. Liposarcoma, Myxoid / genetics. Liposarcoma, Myxoid / pathology. Molecular Diagnostic Techniques. Molecular Targeted Therapy. Neoplasm Transplantation. Sarcoma, Synovial / diagnosis. Sarcoma, Synovial / drug therapy. Sarcoma, Synovial / genetics. Sarcoma, Synovial / pathology. Signal Transduction / genetics

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  • (PMID = 20711583.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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95. Mankey CC, McHugh JB, Thomas DG, Lucas DR: Can lymphangiosarcoma be resurrected? A clinicopathological and immunohistochemical study of lymphatic differentiation in 49 angiosarcomas. Histopathology; 2010 Feb;56(3):364-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Can lymphangiosarcoma be resurrected? A clinicopathological and immunohistochemical study of lymphatic differentiation in 49 angiosarcomas.
  • AIMS: The term lymphangiosarcoma has largely been abandoned in the current classification of endothelial neoplasms.
  • Recently, a number of lymphatic-associated antibodies have been developed for immunohistochemistry, which frequently stain angiosarcomas, implying lymphatic or mixed lymphatic and blood vascular differentiation is common.
  • METHODS AND RESULTS: Forty-nine angiosarcomas in tissue microarrays were analysed with D2-40 and antibodies to Prox-1 and vascular endothelial growth factor receptor (VEGFR)-3.
  • CONCLUSIONS: Lymphatic differentiation is common in angiosarcoma, certain subsets show greater lymphatic differentiation than others, and lymphangiosarcoma may be defined pathologically, rather than clinically.
  • [MeSH-major] Antibodies, Monoclonal. Endothelium, Lymphatic / pathology. Hemangiosarcoma / pathology. Lymphangiosarcoma / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Antibodies, Monoclonal, Murine-Derived. Cell Differentiation. Female. Homeodomain Proteins / metabolism. Humans. Immunohistochemistry. Male. Middle Aged. Receptors, Vascular Endothelial Growth Factor / metabolism. Tissue Array Analysis. Tumor Suppressor Proteins / metabolism

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  • (PMID = 20459536.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Homeodomain Proteins; 0 / Tumor Suppressor Proteins; 0 / monoclonal antibody D2-40; 0 / prospero-related homeobox 1 protein; EC 2.7.10.1 / Receptors, Vascular Endothelial Growth Factor
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96. Rapidis AD: Sarcomas of the head and neck in adult patients: current concepts and future perspectives. Expert Rev Anticancer Ther; 2008 Aug;8(8):1271-97
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sarcomas of the head and neck in adult patients: current concepts and future perspectives.
  • Sarcomas comprise a heterogeneous and biologically diverse group of malignant neoplasms having as a common denominator their origin from mesenchymal cells.
  • Head and neck sarcomas account for 4 to less than 20% of total body sarcomas depending on the criteria, such as age of patients (pediatric vs adult population), type of sarcomas (soft-tissue vs bony sarcomas) and site of location.
  • Although head and neck sarcomas occur infrequently in adults, in the pediatric population one in three sarcomas will occur in the head and neck region.
  • Most head and neck sarcomas are of the soft-tissue type, with only 20% being of bony or cartilaginous origin.
  • Sarcomas display a diverse array of histologies and a wide spectrum of clinical behavior, ranging from relatively slow growing lesions to aggressive locally and regionally destructive tumors with the potential for systemic metastases.
  • Osteosarcomas, rhabdomyosarcomas, pleomorphic sarcomas (malignant fibrous histiocytomas), fibrosarcomas and angiosarcomas are among the most common histologic types of sarcoma found in the head and neck.
  • Surgery has been the primary therapeutic approach for the management of head and neck sarcomas.
  • Survival rates for head and neck sarcomas suggest worse outcomes than for their extremity counterparts.
  • Lymph node metastasis only occurs in 3-10% of sarcomas of the head and neck.
  • An improvement in local disease control has recently been suggested with the combined use of surgery and radiotherapy.
  • Conflicting results have been reported on the benefit from the use of chemotherapy as an adjuvant or neoadjuvant regimen, especially for high-grade sarcomas in long-term survival or local disease control.
  • [MeSH-major] Head and Neck Neoplasms / therapy. Sarcoma / therapy

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  • (PMID = 18699765.001).
  • [ISSN] 1744-8328
  • [Journal-full-title] Expert review of anticancer therapy
  • [ISO-abbreviation] Expert Rev Anticancer Ther
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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97. Guirguis A, Kanbour-Shakir A, Kelley J: Epithelioid angiosarcoma of the mons after chemoradiation for vulvar cancer. Int J Gynecol Pathol; 2007 Jul;26(3):265-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epithelioid angiosarcoma of the mons after chemoradiation for vulvar cancer.
  • Angiosarcomas are rare malignant tumors of endothelial origin with morphological properties similar to the vascular and lymphatic endothelium.
  • Our patient is the first case report of an angiosarcoma of the mons pubis after chemoradiation and the second reported angiosarcoma of the mons.
  • She presented 4 years later with a lesion on her mons, consistent with an angiosarcoma.
  • Angiosarcomas are rare malignant tumors of endothelial origin with morphological properties similar to the vascular and lymphatic endothelium.
  • Our patient is the first case report of an angiosarcoma of the mons pubis after chemoradiation for vulvar cancer and the second reported angiosarcoma of the mons.
  • As the treatment of vulvar cancer evolves, and more radiation therapy is given, the incidence of angiosarcomas will rise, requiring better diagnostic and treatment protocols.
  • [MeSH-major] Hemangiosarcoma / pathology. Vulvar Neoplasms / pathology

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  • (PMID = 17581409.001).
  • [ISSN] 0277-1691
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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98. Tse LF, Ek ET, Slavin JL, Schlicht SM, Choong PF: Intraosseous angiosarcoma with secondary aneurysmal bone cysts presenting as an elusive diagnostic challenge. Int Semin Surg Oncol; 2008;5:10
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  • [Title] Intraosseous angiosarcoma with secondary aneurysmal bone cysts presenting as an elusive diagnostic challenge.
  • Angiosarcoma of bone is an exceedingly rare primary bone malignancy that can present as an aggressive osteolytic lesion.
  • Histological diagnosis can be extremely challenging, as the pathological features often resemble that of aneurysmal bone cysts.
  • We report an interesting and peculiar case of an intraosseous angiosarcoma that presented as a diagnostic dilemma and discuss the relevant radiological and pathologic findings.

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  • [ISSN] 1477-7800
  • [Journal-full-title] International seminars in surgical oncology : ISSO
  • [ISO-abbreviation] Int Semin Surg Oncol
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99. Husain EA, Prescott RJ, Haider SA, Al-Mahmoud RW, Zelger BG, Zelger B, Al-Daraji WI: Gallbladder sarcoma: a clinicopathological study of seven cases from the UK and Austria with emphasis on morphological subtypes. Dig Dis Sci; 2009 Feb;54(2):395-400
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gallbladder sarcoma: a clinicopathological study of seven cases from the UK and Austria with emphasis on morphological subtypes.
  • BACKGROUND: Primary sarcoma of the gallbladder (PGBS) is rare, with only 40 cases reported in the literature.
  • DESIGN: Cases recorded as "gallbladder sarcoma" from different institutes were reviewed and the clinicopathological features of these cases were recorded.
  • Epithelial tumors, mixed tumors (carcinosarcoma or sarcomatoid carcinoma), and tumors extending into the gallbladder from the abdomen or sarcoma with other known primaries were specifically excluded.
  • Based on morphological and immunohistochemical features of the PGBS, there were three myxofibrosarcomas (malignant fibrous histiocytoma, MFH, storiform pleomorphic), one leiomyosarcoma (LMS), one angiosarcoma (AS), and two liposarcomas (LS).
  • Follow-up revealed that six patients died of the disease 6 weeks to 2 years after diagnosis and one died of unrelated causes.
  • A variety of sarcoma types are found with MFH being the predominant variant.
  • [MeSH-major] Gallbladder / pathology. Gallbladder Neoplasms / pathology. Sarcoma / pathology

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  • (PMID = 18618258.001).
  • [ISSN] 1573-2568
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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100. Gabor LJ, Vanderstichel RV: Primary cerebral hemangiosarcoma in a 6-week-old dog. Vet Pathol; 2006 Sep;43(5):782-4
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  • [Title] Primary cerebral hemangiosarcoma in a 6-week-old dog.
  • A primary cerebral hemangiosarcoma was identified in a 6-week-old, female, cross-breed dog.
  • Microscopically, the tumor was composed of an infiltrative mass of small vascular channels lined by neoplastic endothelial cells that stained variably with factor VIII-related antigen and negatively with glial fibrillary acidic protein.
  • This is the first description of a primary intracranial hemangiosarcoma in an immature dog.
  • [MeSH-major] Brain Neoplasms / veterinary. Dog Diseases / pathology. Hemangiosarcoma / veterinary

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  • (PMID = 16966462.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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