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1. Singh D, Gill IS: Renal artery pseudoaneurysm following laparoscopic partial nephrectomy. J Urol; 2005 Dec;174(6):2256-9
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  • [Title] Renal artery pseudoaneurysm following laparoscopic partial nephrectomy.
  • PURPOSE: We describe the presentation, evaluation and management of hemorrhage due to renal artery pseudoaneurysm following laparoscopic partial nephrectomy.
  • MATERIALS AND METHODS: Of the 345 laparoscopic partial nephrectomies performed by us during a 5-year period 6 patients (1.7%) had postoperative hemorrhage from a renal artery pseudoaneurysm.
  • The mean percent of kidney excised was 31% and pelvicaliceal system entry was suture repaired in all 6 patients.
  • Angiography revealed a renal artery pseudoaneurysm most commonly at a third or fourth order branch (4 and 2 patients, respectively).
  • CONCLUSIONS: Renal artery pseudoaneurysm is an uncommon complication following laparoscopic partial nephrectomy.
  • [MeSH-major] Aneurysm, False / etiology. Laparoscopy. Nephrectomy / adverse effects. Nephrectomy / methods. Renal Artery / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Angiography. Angiomyolipoma / surgery. Carcinoma, Renal Cell / surgery. Embolization, Therapeutic. Female. Humans. Kidney Neoplasms / surgery. Length of Stay. Male. Middle Aged. Ohio. Postoperative Hemorrhage / etiology. Postoperative Hemorrhage / therapy. Retrospective Studies. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 16280793.001).
  • [ISSN] 0022-5347
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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2. Kamimura K, Oosaki A, Sugahara S, Mori S, Moroda T, Satoh O, Morita T, Kimura K, Kamura T, Nomoto M, Aoyagi Y: Malignant potential of hepatic angiomyolipoma: case report and literature review. Clin J Gastroenterol; 2010 Apr;3(2):104-10
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  • [Title] Malignant potential of hepatic angiomyolipoma: case report and literature review.
  • Hepatic angiomyolipoma (AML) is known as a rare benign tumor with invasive growth.

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  • [Cites] Eur J Gastroenterol Hepatol. 2000 May;12(5):579-82 [10833105.001]
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  • (PMID = 26190004.001).
  • [ISSN] 1865-7257
  • [Journal-full-title] Clinical journal of gastroenterology
  • [ISO-abbreviation] Clin J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Keywords] NOTNLM ; HMB-45 / Hepatic angiomyolipoma / Malignant / PEComa / Portal vein thrombosis
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3. Blick C, Ravindranath N, Muneer A, Jones A: Bilateral renal angiomyolipomas with invasion of the renal vein: a case report. ScientificWorldJournal; 2008;8:145-8
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  • [Title] Bilateral renal angiomyolipomas with invasion of the renal vein: a case report.
  • An angiomyolipoma (AML) is usually a benign, rare, and, more commonly, a unilateral renal tumour.
  • [MeSH-major] Angiomyolipoma / pathology. Kidney Neoplasms / pathology. Renal Veins / pathology

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  • (PMID = 18264631.001).
  • [ISSN] 1537-744X
  • [Journal-full-title] TheScientificWorldJournal
  • [ISO-abbreviation] ScientificWorldJournal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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4. Katsanos K, Sabharwal T, Ahmad F, Dourado R, Adam A: Onyx embolization of sporadic angiomyolipoma. Cardiovasc Intervent Radiol; 2009 Nov;32(6):1291-5
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  • [Title] Onyx embolization of sporadic angiomyolipoma.
  • Percutaneous embolization is the currently preferred treatment of symptomatic or ruptured renal angiomyolipomas (AMLs).
  • [MeSH-major] Angiomyolipoma / therapy. Dimethyl Sulfoxide / therapeutic use. Kidney Neoplasms / therapy. Polyvinyls / therapeutic use

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  • (PMID = 19083054.001).
  • [ISSN] 1432-086X
  • [Journal-full-title] Cardiovascular and interventional radiology
  • [ISO-abbreviation] Cardiovasc Intervent Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Onyx copolymer; 0 / Polyvinyls; YOW8V9698H / Dimethyl Sulfoxide
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5. Bissler JJ, McCormack FX, Young LR, Elwing JM, Chuck G, Leonard JM, Schmithorst VJ, Laor T, Brody AS, Bean J, Salisbury S, Franz DN: Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis. N Engl J Med; 2008 Jan 10;358(2):140-51
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  • [Title] Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis.
  • METHODS: We conducted a 24-month, nonrandomized, open-label trial to determine whether sirolimus reduces the angiomyolipoma volume in patients with the tuberous sclerosis complex or sporadic lymphangioleiomyomatosis.
  • The mean (+/-SD) angiomyolipoma volume at 12 months was 53.2+/-26.6% of the baseline value (P<0.001) and at 24 months was 85.9+/-28.5% of the baseline value (P=0.005).
  • At 24 months, five patients had a persistent reduction in the angiomyolipoma volume of 30% or more.
  • [MeSH-major] Angiomyolipoma / drug therapy. Immunosuppressive Agents / therapeutic use. Lung Neoplasms / complications. Lymphangioleiomyomatosis / complications. Sirolimus / therapeutic use. Tuberous Sclerosis / complications
  • [MeSH-minor] Adult. Brain / pathology. Female. Humans. Kidney Diseases / pathology. Liver Diseases / pathology. Lung / diagnostic imaging. Lung / physiopathology. Magnetic Resonance Imaging. Male. Middle Aged. Protein Kinase Inhibitors / therapeutic use. Protein Kinases / metabolism. Radiography. Respiratory Function Tests. TOR Serine-Threonine Kinases


6. Godara R, Vashist MG, Singla SL, Garg P, Sen J, Mathur SK, Gupta A: Adrenal angiomyolipoma: A rare entity. Indian J Urol; 2007 Jul;23(3):319-20
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  • [Title] Adrenal angiomyolipoma: A rare entity.
  • Angiomyolipoma is apparently a part of a family of neoplasms that derive from perivascular epitheloid cells.
  • It is a rare mesenchymal tumor, usually found in the kidney.
  • Extrarenal angiomyolipoma is uncommon and the most common extrarenal site is the liver.
  • Only two cases of adrenal angiomyolipoma are reported in English literature.

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  • [Cites] J Am Acad Dermatol. 2006 Jan;54(1):167-71 [16384779.001]
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  • (PMID = 19718340.001).
  • [ISSN] 0970-1591
  • [Journal-full-title] Indian journal of urology : IJU : journal of the Urological Society of India
  • [ISO-abbreviation] Indian J Urol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2721616
  • [Keywords] NOTNLM ; Adrenal / angiomyolipoma / extrarenal
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7. Yoshikawa T, Kawamitsu H, Mitchell DG, Ohno Y, Ku Y, Seo Y, Fujii M, Sugimura K: ADC measurement of abdominal organs and lesions using parallel imaging technique. AJR Am J Roentgenol; 2006 Dec;187(6):1521-30
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  • In 200 consecutive clinical patients (122 men and 78 women: mean age, 61.9 years), ADCs were calculated for liver (four segments), spleen, pancreas (head, body, tail), gallbladder, renal parenchyma, and back muscle, and then compared to evaluate the reliability of clinical ADC measurements with parallel imaging.
  • There was no significant difference among ADCs of four liver segments (1.50 +/- 0.24 [SD] x 10(-3) mm2/s - 1.56 +/- 0.31 x 10(-3) mm2/s) and between ADCs of the right and left kidneys (2.65 +/- 0.30 x 10(-3) mm2/s, 2.59 +/- 0.33 x 10(-3) mm2/s).
  • Renal ADCs were significantly lower in patients with renal failure (right: 2.15 +/- 0.30 x 10(-3) mm2/s; left: 2.11 +/- 0.25 x 10(-3) mm2/s) than in those without disease (right: 2.67 +/- 0.29 x 10(-3) mm2/s; left: 2.60 +/- 0.32 x 10(-3) mm2/s) (p < 0.005).
  • ADC of renal angiomyolipoma was significantly lower than those of renal cell carcinoma and healthy renal parenchyma (p < 0.0005).
  • [MeSH-major] Diffusion Magnetic Resonance Imaging / methods. Digestive System / pathology. Gastrointestinal Neoplasms / diagnosis

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  • (PMID = 17114546.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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8. Zhang LH, Sun RC, Chen Y: [A case report of epiglottic angiomyolipoma. ]. Zhonghua Bing Li Xue Za Zhi; 2005 Oct;34(10):645
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  • [Title] [A case report of epiglottic angiomyolipoma. ].
  • [MeSH-major] Angiomyolipoma / pathology. Epiglottis. Laryngeal Neoplasms / pathology

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  • (PMID = 17526131.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Actins; 0 / smooth muscle actin, rat; 9001-27-8 / Factor VIII
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9. Schillinger F, Montagnac R: [Renal lesions in tuberous sclerosis]. Nephrol Ther; 2006 Jan;2 Suppl 2:S123-6
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  • [Title] [Renal lesions in tuberous sclerosis].
  • Renal tumours, in tuberous sclerosis, are mainly benign and correspond to angiomyolipomas, multiple and bilateral, sometimes enormous with an hemorrhagic risk, frequently associated with cysts of variable size and number and seldom with high metastatic carcinomas.
  • Chronic renal failure is rare and related to focal glomerulosclerosis secondary to hyperfiltration due to nephronic reduction owing to surgery or to tumour invasion, in particular cysts.
  • Data about 65 patients with tuberous sclerosis and chronic renal failure were collected thanks to a national survey.
  • They were females in 63.1% of cases, with a mean age of 29, 2 years at the time of the diagnosis of tuberous sclerosis, revealed in near half of cases by renal involvement.
  • All but one of the 48 patients with end stage renal failure were treated by dialysis; 20 were transplanted, with good results.
  • [MeSH-major] Kidney / pathology. Kidney Neoplasms / epidemiology. Tuberous Sclerosis / pathology
  • [MeSH-minor] Angiomyolipoma / diagnosis. Angiomyolipoma / epidemiology. Angiomyolipoma / pathology. Glomerulosclerosis, Focal Segmental / etiology. Humans. Kidney Failure, Chronic / complications. Neoplasm Invasiveness


10. Tamai H, Takiguchi Y, Oka M, Shingaki N, Enomoto S, Shiraki T, Furuta M, Inoue I, Iguchi M, Yanaoka K, Arii K, Shimizu Y, Nakata H, Shinka T, Sanke T, Ichinose M: Contrast-enhanced ultrasonography in the diagnosis of solid renal tumors. J Ultrasound Med; 2005 Dec;24(12):1635-40
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  • [Title] Contrast-enhanced ultrasonography in the diagnosis of solid renal tumors.
  • OBJECTIVE: The purpose of this study was to evaluate the usefulness of contrast-enhanced ultrasonography (CEUS) in the diagnosis of solid renal tumors.
  • METHODS: Twenty-nine patients with solid tumors detected on gray scale ultrasonography underwent resection for suspected renal malignancy.
  • Findings of arterial phase contrast computed tomography (CT) and CEUS were compared for each diagnosis.
  • RESULTS: Histopathologic examination of resected lesions showed malignancy in 26 patients (clear cell carcinoma, n = 18; papillary renal cell carcinoma, n = 6; collecting duct carcinoma, n = 1; and infiltrative urothelial carcinoma, n = 1) and benign tumors in 3 patients (oncocytoma, n = 2; and angiomyolipoma, n = 1).
  • Positive predictive values of CEUS and contrast CT in the diagnosis of renal malignancy were 100% and 82.8%, respectively.
  • However, CEUS showed blood flow in these lesions, leading to diagnosis of hypovascular renal tumors.
  • CONCLUSIONS: Contrast-enhanced ultrasonography was more sensitive for detecting slight tumor blood flow than contrast CT and was useful in preoperatively diagnosing malignant hypovascular renal tumors but was less so for hypervascular renal tumors.
  • [MeSH-major] Contrast Media. Image Enhancement / methods. Kidney Neoplasms / radiography. Kidney Neoplasms / ultrasonography. Neovascularization, Pathologic / radiography. Neovascularization, Pathologic / ultrasonography. Ultrasonography / methods

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  • (PMID = 16301719.001).
  • [ISSN] 0278-4297
  • [Journal-full-title] Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
  • [ISO-abbreviation] J Ultrasound Med
  • [Language] eng
  • [Publication-type] Controlled Clinical Trial; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
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11. McKinney CA, Geiger JD, Castle VP, Ruiz RE, Strouse PJ: Aggressive hepatic angiomyolipoma in a child. Pediatr Hematol Oncol; 2005 Jan-Feb;22(1):17-24
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  • [Title] Aggressive hepatic angiomyolipoma in a child.
  • Angiomyolipoma is a tumor of the kidney and, more rarely, the liver, which histologically consists of smooth muscle cells, adipose cells, and abnormal blood vessels in varying proportions.
  • This tumor is generally benign and resection is curative, but here the authors present the case of a 14-year-old girl with an unusual primary hepatic angiomyolipoma that recurred following resection and behaved aggressively.
  • [MeSH-major] Angiomyolipoma / pathology. Liver Neoplasms / pathology

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  • (PMID = 15770828.001).
  • [ISSN] 0888-0018
  • [Journal-full-title] Pediatric hematology and oncology
  • [ISO-abbreviation] Pediatr Hematol Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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12. Vallmanya F, Placer J, Pou Serradell A, Cortadellas R, Gelabert-Mas A: Tuberous sclerosis complex. Forty-years of follow-up of a patient affected. Arch Esp Urol; 2006 Jan-Feb;59(1):105-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVES: To report the case of a patient diagnosed with tuberous sclerosis complex (TSC), describe its clinical features, diagnosis, and to attract attention on the fact that after 40 years of follow-up, the patient has presented practically all the manifestations described in the literature.
  • Abdominal CT scan showed a 20 cm diameter heterogeneous mass in the left kidney suggesting hemorrhage of an angiomyolipoma.
  • RESULTS: Left radical nephrectomy was performed and the pathological study of the surgical specimen confirmed the diagnosis of angiomyolipoma.
  • CT scan is usually enough for the diagnosis of angiomyolipomas.
  • Complete nephrectomy is appropriate when the whole kidney has been replaced by angiomyolipoma.
  • The identification of molecular markers (HMB-45) facilitates histopathological diagnosis.
  • [MeSH-major] Tuberous Sclerosis / diagnosis

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  • (PMID = 16568704.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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13. Williams TR, Oakes MF: Metastatic breast carcinoma to renal angiomyolipomas in tuberous sclerosis. Urology; 2008 Feb;71(2):352.e5-7
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  • [Title] Metastatic breast carcinoma to renal angiomyolipomas in tuberous sclerosis.
  • Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disease manifesting as hamartomatous involvement of several organs, including brain, kidneys, skin, heart, lungs, and retina.
  • We report the first case of a patient with TSC, with large bilateral renal angiomyolipomas (AML), who developed multiple soft tissue masses within her primarily fatty AMLs, resulting from metastatic breast cancer.
  • [MeSH-major] Angiomyolipoma / complications. Angiomyolipoma / pathology. Breast Neoplasms / complications. Breast Neoplasms / pathology. Kidney Neoplasms / complications. Kidney Neoplasms / secondary. Tuberous Sclerosis / complications


14. Wright T, Sooriakumaran P: Renal angiomyolipoma presenting with massive retroperitoneal haemorrhage due to deranged clotting factors: a case report. Cases J; 2008;1(1):213
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  • [Title] Renal angiomyolipoma presenting with massive retroperitoneal haemorrhage due to deranged clotting factors: a case report.
  • BACKGROUND: Angiomyolipomata of the kidney are unusual lesions composed of abnormal vasculature, smooth muscle, and adipose elements.
  • The underlying diagnosis of renal angiomyolipoma was diagnosed based on CT findings.
  • Emergency resuscitation and selective interpolar arterial embolization was performed which saved the patient's life as well as his kidney.
  • CONCLUSION: This case illustrates the clinical scenario of massive retroperitoneal haemorrhage in an anticoagulated patient with renal angiomyolipomata.
  • In the emergent situation, adequate resuscitation along ABC principles, as well as control of haemorrhage with either nephrectomy (partial or radical), non-selective renal arterial embolization, or selective embolization of the feeding vessel(s), is necessary.
  • For this to occur, it is imperative to consider the diagnosis early in warfarinized patients (and others at risk of bleeding) who present with abdominal pain.
  • The authors hope this case report highlights to readers the clinical scenario of massive retroperitoneal haemorrhage in anticoagulated patients with renal angiomyolipomata so that they can deal appropriately with such presentations.

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  • (PMID = 18834543.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2567302
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15. Marsilia GM, Boscaino A, La Mura A, Ceriello A, De Ritis R: Hepatic angiomyolipoma and intramural small intestinal schwannoma: a coincidence or a relationship? Int J Surg Pathol; 2010 Dec;18(6):537-9
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  • [Title] Hepatic angiomyolipoma and intramural small intestinal schwannoma: a coincidence or a relationship?
  • We report a case of hepatic angiomyolipoma associated to a small bowel schwannoma in a 40-years old woman.
  • Histologically, hepatic angiomyolipoma showed oncocytic features and scanty adipose tissue, the tumor cells expressed desmin, smooth muscle actin, S-100 protein and HMB45.
  • To the best of our knowledge, no case of hepatic angiomyolipoma has been previously reported in association with intestinal schwannoma.
  • [MeSH-major] Angiomyolipoma / pathology. Jejunal Neoplasms / pathology. Liver Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Neurilemmoma / pathology

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  • (PMID = 19282295.001).
  • [ISSN] 1940-2465
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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16. Jiménez Heffernan JA, González-Peramato P, Vicandi B, López Ferrer P, Serrano A, Pérez Campos A, Viguer JM: [Usefulness of cytology in diagnosis and management of renal and perirenal tumors in adults]. Actas Urol Esp; 2007 Oct;31(9):957-65
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  • [Title] [Usefulness of cytology in diagnosis and management of renal and perirenal tumors in adults].
  • INTRODUCTION: The use more and more extended of tumorectomy, partial nephrectomy and nonsurgical treatments of renal tumors has supposed a renewed interest in the diagnosis use of cytology.
  • Whether during preoperative period, through the puncture aspiration with fine needle (PAAF), or during the intraoperative analysis, the cytology offers the possibility of a specific morphologic diagnosis.
  • In this revision the information concerning the diagnostic value of the cytology in renal tumors is updated.
  • MATERIAL AND METHODS: The references related to renal masses cytological descriptions has been reviewed.
  • RESULTS: Between neoplasias with more cytological typical presentation are the clear cell renal and papillary carcinomas.
  • For the diagnosis of angiomyolipoma, urothelial carcinoma and kidney metastasis, the clinical and image information are of great interest for the pathologist.
  • The integration of these data usually allows a specific diagnosis.
  • CONCLUSION: Generally, cytology reflects with accuracy the histological characteristics of renal neoplasias, allowing in many cases a specific diagnosis.
  • [MeSH-major] Carcinoma, Renal Cell / pathology. Kidney Neoplasms / pathology

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  • (PMID = 18257365.001).
  • [ISSN] 0210-4806
  • [Journal-full-title] Actas urologicas españolas
  • [ISO-abbreviation] Actas Urol Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 52
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17. Woodward PJ, Sohaey R, Kennedy A, Koeller KK: From the archives of the AFIP: a comprehensive review of fetal tumors with pathologic correlation. Radiographics; 2005 Jan-Feb;25(1):215-42
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  • Other fetal neoplasms include soft-tissue tumors (both benign and malignant), leukemia, mesenchymal hamartoma of the kidney, and liver tumors (hemangioendothelioma, mesenchymal hamartoma, and hepatoblastoma).
  • [MeSH-major] Fetal Diseases / diagnosis. Neoplasms / diagnosis
  • [MeSH-minor] Brain Neoplasms / diagnosis. Female. Humans. Magnetic Resonance Imaging. Pregnancy. Teratoma / diagnosis. Ultrasonography, Prenatal

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  • (PMID = 15653597.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 82
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18. Ahmed M, Aslam M, Ahmed J, Faraz HA, Almahfouz A, Al Arifi A, Raef H, Dayel FA: Renal metastases from thyroid cancer masquerading as renal angiomyolipoma on ultrasonography. J Ultrasound Med; 2006 Nov;25(11):1459-64
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Renal metastases from thyroid cancer masquerading as renal angiomyolipoma on ultrasonography.
  • [MeSH-major] Angiomyolipoma / ultrasonography. Kidney Neoplasms / secondary. Kidney Neoplasms / ultrasonography. Neoplasm Metastasis / ultrasonography. Thyroid Neoplasms / ultrasonography

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  • (PMID = 17060435.001).
  • [ISSN] 0278-4297
  • [Journal-full-title] Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
  • [ISO-abbreviation] J Ultrasound Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Iodine Isotopes
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19. Hornick JL, Fletcher CD: Sclerosing PEComa: clinicopathologic analysis of a distinctive variant with a predilection for the retroperitoneum. Am J Surg Pathol; 2008 Apr;32(4):493-501
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  • PEComas (tumors showing perivascular epithelioid cell differentiation) are a family of mesenchymal neoplasms that include angiomyolipoma, clear cell "sugar" tumor of the lung, lymphangiomyomatosis, and a group of uncommon lesions that arise in soft tissue, visceral organs, and skin.

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  • (PMID = 18223480.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, Neoplasm; 0 / Calmodulin-Binding Proteins; 0 / Desmin; 0 / MART-1 Antigen; 0 / MITF protein, human; 0 / MLANA protein, human; 0 / Melanoma-Specific Antigens; 0 / Microphthalmia-Associated Transcription Factor; 0 / Mucin-1; 0 / Neoplasm Proteins; 0 / S100 Proteins; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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20. Graham RP, Coard KC: Angiomyolipoma of the kidney: the experience at the University Hospital of the West Indies. West Indian Med J; 2009 Dec;58(6):556-60
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  • [Title] Angiomyolipoma of the kidney: the experience at the University Hospital of the West Indies.
  • OBJECTIVE: Angiomyolipoma (AML) of the kidney is an uncommon tumour that, until recently, was often misdiagnosed preoperatively as renal cell carcinoma (RCC).
  • Newer radiological techniques have allowed more accurate preoperative diagnosis which can facilitate preoperative counselling and planning for conservative therapy.
  • These included patient demographics, clinical history, clinical diagnosis and pathologic characteristics of the specimen submitted.
  • The total number of primary renal tumours diagnosed in adults during the same period was also determined for comparison.
  • RESULTS: Eleven cases of AML were identified among 149 primary renal tumours in adults.
  • The correct clinical diagnosis was made pre-operatively in a single case.
  • By contrast, a diagnosis of RCC or other malignant tumour was proffered in eight cases.
  • [MeSH-major] Angiomyolipoma / diagnosis. Kidney Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma, Renal Cell / diagnosis. Diagnosis, Differential. Female. Hospitals, University. Humans. Jamaica. Male. Middle Aged. Retrospective Studies. Sex Factors. Tuberous Sclerosis / complications. Young Adult

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  • (PMID = 20583682.001).
  • [ISSN] 0043-3144
  • [Journal-full-title] The West Indian medical journal
  • [ISO-abbreviation] West Indian Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Jamaica
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21. Lipsky M, Richardson I, Tareen B: A case of pararenal angiomyolipoma arising from an existing exophytic angiomyolipoma. Can Urol Assoc J; 2010 Jun;4(3):E79-81
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  • [Title] A case of pararenal angiomyolipoma arising from an existing exophytic angiomyolipoma.
  • A 52-year-old healthy woman with a congenital solitary right kidney presented with an incidentally found pararenal mass.
  • Computed tomography and magnetic resonance imaging revealed an exophytic mass in the right kidney consistent with an angiomyolipoma and an additional enhancing pararenal mass that contained fatty elements.
  • Differential diagnosis of the mass included liposarcoma and angiomyolipoma.
  • Upon exploration, the exophytic angiomyolipoma was found to be contiguous with the pararenal mass via an isthmus of fatty tissue.
  • Frozen sections were taken from both masses which confirmed that both were angiomyolipoma.
  • This is the first case reported in the literature wherein an angiomyolipoma extended extrarenally and formed a significantly larger pararenal mass.

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  • [Cites] J Urol. 1992 Feb;147(2):447-50 [1732615.001]
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  • (PMID = 23293694.001).
  • [ISSN] 1920-1214
  • [Journal-full-title] Canadian Urological Association journal = Journal de l'Association des urologues du Canada
  • [ISO-abbreviation] Can Urol Assoc J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC3499926
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22. Umeoka S, Koyama T, Miki Y, Akai M, Tsutsui K, Togashi K: Pictorial review of tuberous sclerosis in various organs. Radiographics; 2008 Nov-Dec;28(7):e32
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  • The diagnosis is usually established on the basis of diagnostic criteria applied to physical or radiologic findings.
  • Because the classical triad of epilepsy, mental retardation, and adenoma sebaceum is uncommonly seen at clinical examination, radiologic examinations can play an important role in the diagnosis of tuberous sclerosis and in treatment.
  • Cardiac rhabdomyoma, renal angiomyolipoma, and neurologic involvement encompassing cortical or subependymal tubers and white matter abnormalities are the common radiologic findings.
  • The presence of pulmonary lymphangioleiomyomatosis, multifocal micronodular pneumocyte hyperplasia, or multiple renal cysts also raises suspicion of tuberous sclerosis.
  • Familiarity with the clinical and radiologic findings in various organs is crucial in diagnosis and treatment.
  • [MeSH-major] Multiple Organ Failure / diagnosis. Tomography, X-Ray Computed / methods. Tuberous Sclerosis / diagnosis

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  • (PMID = 18772274.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 60
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23. De Padua M, Gupta N, Broor SL, Govil D: Duodenal angiomyolipoma: a case report. Indian J Pathol Microbiol; 2007 Jul;50(3):568-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Duodenal angiomyolipoma: a case report.
  • The authors present a case of duodenal angiomyolipoma.
  • Angiomyolipoma is a benign neoplasm, the most common site being the kidney.
  • Only one case of duodenal angiomyolipoma has been reported.
  • Endoscopy revealed a duodenal polyp which on histopathology revealed features of angiomyolipoma.
  • Surgical excision of angiomyolipoma is usually curative with rare cases of local recurrence.
  • [MeSH-major] Angiomyolipoma / diagnosis. Duodenum / pathology. Intestinal Neoplasms / diagnosis

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  • [CommentIn] Indian J Pathol Microbiol. 2010 Oct-Dec;53(4):859 [21045449.001]
  • (PMID = 17883138.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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24. Kannangai R, Diehl AM, Sicklick J, Rojkind M, Thomas D, Torbenson M: Hepatic angiomyolipoma and hepatic stellate cells share a similar gene expression profile. Hum Pathol; 2005 Apr;36(4):341-7
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  • [Title] Hepatic angiomyolipoma and hepatic stellate cells share a similar gene expression profile.
  • [MeSH-major] Angiomyolipoma / metabolism. Hepatocytes / metabolism

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  • (PMID = 15891994.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Grant] United States / NIAAA NIH HHS / AA / AA010154; United States / NIAAA NIH HHS / AA / AA10541; United States / NIDA NIH HHS / DA / DA016078; United States / NIDA NIH HHS / DA / DA016370; United States / NIDDK NIH HHS / DK / DK53792
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins
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25. Ozkara H, Ozkan B, Solok V: Management of renal abscess formation after embolization due to renal angiomyolipomas in two cases. Int Urol Nephrol; 2006;38(3-4):427-9
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  • [Title] Management of renal abscess formation after embolization due to renal angiomyolipomas in two cases.
  • Current management strategies of renal angiomyolipomas (AMLs) include observation, embolization and partial or total nephrectomy.
  • Percutaneous drainage was the recommended treatment for renal abscess formation following the embolization.
  • [MeSH-major] Abscess / etiology. Abscess / therapy. Angiomyolipoma / complications. Angiomyolipoma / therapy. Embolization, Therapeutic / adverse effects. Kidney Diseases / etiology. Kidney Diseases / therapy. Kidney Neoplasms / complications. Kidney Neoplasms / therapy. Staphylococcal Infections / etiology. Staphylococcal Infections / therapy


26. Patil AR, Chandra R, Gupta A, Thukral BB: Giant aneurysm formation in sporadic renal angiomyolipoma. J Radiol Case Rep; 2010;4(6):21-7
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  • [Title] Giant aneurysm formation in sporadic renal angiomyolipoma.
  • Angiomyolipomas are the most common mesenchymal renal neoplasms.
  • Two types have been described: (i) sporadic angiomyolipoma and (ii) angiomyolipoma associated with tuberous sclerosis.
  • We report a rare case of aneurysm formation in a sporadic angiomyolipoma.

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  • (PMID = 22470737.001).
  • [ISSN] 1943-0922
  • [Journal-full-title] Journal of radiology case reports
  • [ISO-abbreviation] J Radiol Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3303414
  • [Keywords] NOTNLM ; Aneurysm / Angiomyolipoma / Computed Tomography / Tuberous Sclerosis complex
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27. Alvarez Alvarez C, Fernández Sanromán J, Fernández Castilla M, Antón Badiola I: Sporadic oral angiomyolipoma. Case report. Med Oral Patol Oral Cir Bucal; 2007 Sep;12(5):E391-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sporadic oral angiomyolipoma. Case report.
  • Angiomyolipoma (AML) is a rare, benign tumour composed of a variable proportion of lipocytes, smooth muscle and thick-walled blood vessels.
  • AML is part of a family of tumours arising from perivascular epithelioid cells (PEComas), and many cases are associated with tuberous sclerosis, with the kidney being the most frequent site involved.
  • AML occurring in the head and neck do not express HMB-45, an antibody that identifies immature melanosomes, conversely to the usual immunopositivity shown in AMLs from kidney and liver, suggesting that there are differences among them.
  • [MeSH-major] Angiomyolipoma. Jaw Neoplasms. Palate, Hard

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  • (PMID = 17767105.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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28. Bragg F, Kumar NP: Orthostatic hypotension in an octogenarian--an unusual presentation. Age Ageing; 2005 May;34(3):307-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Angiomyolipoma / radiography. Hypotension, Orthostatic / radiography. Kidney Neoplasms / radiography

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  • (PMID = 15863420.001).
  • [ISSN] 0002-0729
  • [Journal-full-title] Age and ageing
  • [ISO-abbreviation] Age Ageing
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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29. Shimada S, Harada H, Ishizawa K, Hirose T: Retroperitoneal lipomatous angiomyolipoma associated with amyloid deposition masquerading as well-differentiated liposarcoma. Pathol Int; 2006 Oct;56(10):638-41
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  • [Title] Retroperitoneal lipomatous angiomyolipoma associated with amyloid deposition masquerading as well-differentiated liposarcoma.
  • Reported herein is a case of retroperitoneal angiomyolipoma associated with amyloid deposition, masquerading as well-differentiated liposarcoma.
  • Therefore, the tumor was diagnosed as lipomatous angiomyolipoma.
  • After the diagnosis, it was found that the patient had multiple myeloma and cardiac amyloidosis, suggesting that the amyloid deposition within the tumor was a complication of the myeloma.
  • Lipomatous angiomyolipoma may be a diagnostic pitfall of retroperitoneal lipomatous tumors.
  • [MeSH-major] Amyloid / metabolism. Angiomyolipoma / diagnosis. Angiomyolipoma / metabolism. Liposarcoma / diagnosis. Liposarcoma / metabolism. Retroperitoneal Neoplasms / diagnosis. Retroperitoneal Neoplasms / metabolism
  • [MeSH-minor] Aged. Cyclin-Dependent Kinase 4 / genetics. Cyclin-Dependent Kinase 4 / metabolism. Diagnosis, Differential. Female. Gene Expression Regulation, Enzymologic. Gene Expression Regulation, Neoplastic. Humans. Proto-Oncogene Proteins c-mdm2 / genetics. Proto-Oncogene Proteins c-mdm2 / metabolism

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  • (PMID = 16984623.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Amyloid; EC 2.7.11.22 / Cyclin-Dependent Kinase 4; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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30. Hadley DA, Bryant LJ, Ruckle HC: Conservative treatment of renal angiomyolipomas in patients with tuberous sclerosis. Clin Nephrol; 2006 Jan;65(1):22-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Conservative treatment of renal angiomyolipomas in patients with tuberous sclerosis.
  • AIMS: Renal angiomyolipoma (AML) associated with tuberous sclerosis (TS) presents a treatment dilemma due to multifocal tumors with a potential for significant growth and subsequent hemorrhage.
  • MATERIALS AND METHODS: We reviewed 8 patients (16 renal units) with bilateral renal AMLs and comorbid TS.
  • We evaluated their renal function, renal imaging, and clinical course.
  • The mean serum creatinine of these patients at the time of diagnosis was 0.75 mg/dl (range 0.4 - 1.1).
  • Of the 8 patients, 6 received treatment during the course of their disease, including arterial embolization of 7 renal units in 5 symptomatic patients (2 patients needed 2 embolizations).
  • Partial nephrectomy was performed on 2 renal units in 2 patients, and a total nephrectomy was performed in 1971 on another patient.
  • Currently, all 8 patients have stable renal function; 4 patients are asymptomatic with regards to their lesions, while the other 4 patients report transient flank pain adequately controlled with oral analgesics (2 patients with propoxyphene plus acetaminophen 100/650 mg PO t.i.d. p.r.n., the other 2 patients with ibuprofen 600 mg PO p.r.n.).
  • CONCLUSIONS: Our study and a review of the literature have not revealed an obvious or quantitative risk of morbidity or mortality from renal hemorrhage directly related to AMLs of any specific size in TS patients.
  • [MeSH-major] Angiomyolipoma / therapy. Kidney Neoplasms / therapy. Tuberous Sclerosis / complications

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  • (PMID = 16429838.001).
  • [ISSN] 0301-0430
  • [Journal-full-title] Clinical nephrology
  • [ISO-abbreviation] Clin. Nephrol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Analgesics; AYI8EX34EU / Creatinine
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31. Magro G, Lanzafame S: Sporadic subcutaneous angiomyolipoma with expression of estrogen and progesterone receptors. Virchows Arch; 2007 Jan;450(1):123-5
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  • [Title] Sporadic subcutaneous angiomyolipoma with expression of estrogen and progesterone receptors.
  • [MeSH-major] Angiomyolipoma / pathology. Receptors, Estrogen / analysis. Receptors, Progesterone / analysis. Skin Neoplasms / pathology

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  • [Cites] Chest. 2000 Jan;117(1):25-30 [10631194.001]
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  • (PMID = 17124601.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Receptors, Estrogen; 0 / Receptors, Progesterone
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32. Davis CJ, Barton JH, Sesterhenn IA: Cystic angiomyolipoma of the kidney: a clinicopathologic description of 11 cases. Mod Pathol; 2006 May;19(5):669-74
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  • [Title] Cystic angiomyolipoma of the kidney: a clinicopathologic description of 11 cases.
  • This report deals with 11 examples of renal angiomyolipomas (AML) which appear to include an epithelial element as a part of the neoplasm in the form of gross or microscopic cysts-usually both.
  • Seven tumors were in the right kidney and four in the left.
  • There was usually a subepithelial collar of poorly differentiated cells, but the solid element of all tumors was myomatous angiomyolipoma; only one case had any adipose tissue.
  • [MeSH-major] Angiomyolipoma / pathology. Cysts / pathology. Kidney Neoplasms / pathology

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  • (PMID = 16528375.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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33. Sugimoto T, Morita Y, Kashiwagi A: Spontaneous hemorrhage from renal angiomyolipoma presenting with fever of unknown origin. Intern Med; 2007;46(11):793-4
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  • [Title] Spontaneous hemorrhage from renal angiomyolipoma presenting with fever of unknown origin.
  • [MeSH-major] Angiomyolipoma / complications. Fever of Unknown Origin / etiology. Hematoma / complications. Kidney Neoplasms / complications

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  • (PMID = 17541239.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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34. Kim JY, Kim JK, Kim N, Cho KS: CT histogram analysis: differentiation of angiomyolipoma without visible fat from renal cell carcinoma at CT imaging. Radiology; 2008 Feb;246(2):472-9
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  • [Title] CT histogram analysis: differentiation of angiomyolipoma without visible fat from renal cell carcinoma at CT imaging.
  • PURPOSE: To retrospectively evaluate the diagnostic performance of computed tomographic (CT) histogram analysis for differentiating angiomyolipoma (AML) without visible fat from renal cell carcinoma (RCC) at CT, by using pathologic analysis and clinical diagnosis as the reference standard.
  • [MeSH-major] Adipose Tissue / radiography. Angiomyolipoma / radiography. Carcinoma, Renal Cell / radiography. Kidney Neoplasms / radiography. Radiographic Image Enhancement / methods. Radiographic Image Interpretation, Computer-Assisted / methods. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Algorithms. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Reproducibility of Results. Sensitivity and Specificity

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  • [Copyright] (c) RSNA, 2007.
  • (PMID = 18094264.001).
  • [ISSN] 1527-1315
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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35. Li T, Fan J, Qin LX, Zhou J, Sun HC, Wang L, Ye QH, Qiu SJ, Tang ZY: [A clinicopathologic study of hepatic angiomyolipoma]. Zhonghua Wai Ke Za Zhi; 2009 Oct 15;47(20):1536-9
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  • [Title] [A clinicopathologic study of hepatic angiomyolipoma].
  • OBJECTIVE: To investigate the clinicopathologic features, diagnosis and treatment of hepatic angiomyolipoma (HAML).
  • Definitive diagnosis of HAML depends on the pathohistological findings and HMB-45 positive myoid cell is an important diagnostic marker.
  • [MeSH-major] Angiomyolipoma / pathology. Liver Neoplasms / pathology

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  • (PMID = 20092740.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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36. Johnson SC, Graham S, D'Agostino H, Elmajian DA, Shingleton WB: Percutaneous renal cryoablation of angiomyolipomas in patients with solitary kidneys. Urology; 2009 Dec;74(6):1246-9
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  • [Title] Percutaneous renal cryoablation of angiomyolipomas in patients with solitary kidneys.
  • OBJECTIVES: To determine the feasibility and safety of performing percutaneous cryoablation of angiomyolipomas (AMLs) in patients with solitary kidneys.
  • METHODS: Three patients with AMLs involving a solitary kidney underwent computed tomography-guided percutaneous cryoablation.
  • All lesions were located in the lateral/posterior part of the kidney, allowing for safe access from the skin for cryoprobe insertion.
  • CONCLUSIONS: A review of the published data suggested the necessity to prophylactically treat AMLs of solitary kidneys.
  • [MeSH-major] Angiomyolipoma / surgery. Cryosurgery. Kidney Neoplasms / surgery. Nephrectomy / methods

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  • (PMID = 19815260.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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37. Lee SY, Hsu HH, Chen YC, Huang CC, Wong YC, Wang LJ, Chuang CK, Yang CW: Embolization of renal angiomyolipomas: short-term and long-term outcomes, complications, and tumor shrinkage. Cardiovasc Intervent Radiol; 2009 Nov;32(6):1171-8
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  • [Title] Embolization of renal angiomyolipomas: short-term and long-term outcomes, complications, and tumor shrinkage.
  • This study retrospectively evaluated outcomes, complications, and tumor shrinkage in renal angiomyolipomas after transcatheter arterial embolization (TAE).
  • All renal angiomyolipoma patients who underwent TAE between August 2000 and December 2008 and had short-term (<or=6 months) or long-term (>6 months) follow-up images were evaluated.
  • Eleven renal angiomyolipoma patients who had undergone TAE were included.
  • In conclusion, selective TAE is effective for tumor shrinkage in most renal angiomyolipomas, with acceptable complication and relapse rates.
  • [MeSH-major] Angiomyolipoma / therapy. Embolization, Therapeutic / methods. Kidney Neoplasms / therapy

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  • (PMID = 19572171.001).
  • [ISSN] 1432-086X
  • [Journal-full-title] Cardiovascular and interventional radiology
  • [ISO-abbreviation] Cardiovasc Intervent Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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38. Takahara M, Miyake Y, Matsumoto K, Kawai D, Kaji E, Toyokawa T, Nakatsu M, Ando M, Hirohata M: A case of hepatic angiomyolipoma difficult to distinguish from hepatocellular carcinoma. World J Gastroenterol; 2009 Jun 21;15(23):2930-2
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  • [Title] A case of hepatic angiomyolipoma difficult to distinguish from hepatocellular carcinoma.
  • We report a case of hepatic angiomyolipoma with uncommon clinical features.
  • In cases with uncommon features of angiomyolipoma, it is quite difficult to distinguish angiomyolipoma from hepatocellular carcinoma.
  • [MeSH-major] Angiomyolipoma. Carcinoma, Hepatocellular. Liver Neoplasms

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  • [Cites] Abdom Imaging. 2002 Mar-Apr;27(2):180-3 [11847577.001]
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  • (PMID = 19533821.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC2699017
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39. Turksoy O, Tokgoz H, Toparli S: Re: Radiological classification of renal angiomyolipomas based on 127 tumors. Int Braz J Urol; 2005 May-Jun;31(3):269
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  • [Title] Re: Radiological classification of renal angiomyolipomas based on 127 tumors.
  • [MeSH-major] Angiomyolipoma / radiography. Kidney Neoplasms / radiography

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  • [CommentOn] Int Braz J Urol. 2003 May-Jun;29(3):208-15; discussion 216 [15745523.001]
  • (PMID = 15992433.001).
  • [ISSN] 1677-5538
  • [Journal-full-title] International braz j urol : official journal of the Brazilian Society of Urology
  • [ISO-abbreviation] Int Braz J Urol
  • [Language] eng
  • [Publication-type] Case Reports; Comment; Letter
  • [Publication-country] Brazil
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40. Langen HJ, Markert K, Griesser H: [CT-x ray of a renal cell carcinoma reveals an angiomyolipoma]. Rofo; 2007 Apr;179(4):425-7
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  • [Title] [CT-x ray of a renal cell carcinoma reveals an angiomyolipoma].
  • [MeSH-major] Angiomyolipoma / radiography. Angiomyolipoma / surgery. Carcinoma, Renal Cell / radiography. Carcinoma, Renal Cell / surgery. Kidney Neoplasms / radiography. Kidney Neoplasms / surgery

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  • (PMID = 17377877.001).
  • [ISSN] 1438-9029
  • [Journal-full-title] RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
  • [ISO-abbreviation] Rofo
  • [Language] ger
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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41. Corso R, Carrafiello G, Rampoldi A, Leni D, Ticca C, Vercelli R, Vanzulli A: Pseudoaneurysm after spontaneous rupture of renal angiomyolipoma in tuberous sclerosis: successful treatment with percutaneous thrombin injection. Cardiovasc Intervent Radiol; 2005 Mar-Apr;28(2):262-4
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  • [Title] Pseudoaneurysm after spontaneous rupture of renal angiomyolipoma in tuberous sclerosis: successful treatment with percutaneous thrombin injection.
  • We report a case of a large perinephric pseudoaneurysm due to spontaneous rupture of renal angiomyolipoma, occluded by percutaneous thrombin injection under ultrasound guidance in a young woman affected by tuberous sclerosis.
  • [MeSH-major] Aneurysm, False / etiology. Angiomyolipoma / complications. Embolization, Therapeutic / methods. Hemostatics / therapeutic use. Kidney Neoplasms / complications. Thrombin / therapeutic use. Tuberous Sclerosis / complications

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  • (PMID = 15719182.001).
  • [ISSN] 0174-1551
  • [Journal-full-title] Cardiovascular and interventional radiology
  • [ISO-abbreviation] Cardiovasc Intervent Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hemostatics; EC 3.4.21.5 / Thrombin
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42. Coulibaly B, Bouvier C, Payan MJ, Thomas P: Recurrent dedifferentiated liposarcoma of mediastinum involving lung and pleura. Interact Cardiovasc Thorac Surg; 2009 Oct;9(4):741-2
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  • A woman who complained of dyspnea showed on imaging features a bulky posterior mediastinal mass which was completely excised and initially misdiagnosed as an angiomyolipoma.

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  • (PMID = 19589790.001).
  • [ISSN] 1569-9285
  • [Journal-full-title] Interactive cardiovascular and thoracic surgery
  • [ISO-abbreviation] Interact Cardiovasc Thorac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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43. Bahrami A, Schwartz MR, Ayala AG, Goldfarb RA, Brady JR, Takei H, Ro JY: Concurrent angiomyolipoma and two oncocytomas in the same kidney. Ann Diagn Pathol; 2007 Apr;11(2):132-6
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  • [Title] Concurrent angiomyolipoma and two oncocytomas in the same kidney.
  • We report on a rare case of synchronous angiomyolipoma (AML) and 2 oncocytomas (OCs) in the same kidney of a 73-year-old woman.
  • During the course of a follow-up for a long-standing staghorn calculus in the left kidney, a 4-cm right suprarenal mass and a small solid nodule adjacent to a cyst in the midportion of the right kidney were radiographically discovered.
  • An additional OC (0.8 cm) elsewhere in the right kidney was also identified.
  • The coexistence of AML and other renal tumors is uncommon.
  • Among reported cases, conventional renal cell carcinoma, possibly reflecting its higher incidence, has been the most common concurrent tumor with AML.
  • Although only rare cases of simultaneous AML and OC have been reported in the literature, it appears that the proportion of OC among concurrent renal tumors with AML is higher than expected based on its frequency among all surgically resected renal neoplasms.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Angiomyolipoma / pathology. Kidney Neoplasms / pathology. Neoplasms, Multiple Primary / pathology

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  • (PMID = 17349574.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins
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44. Hsu YP, Chen RJ, Fang JF, Lin BC: Traumatic rupture of renal angiomyolipoma managed with angioembolization followed by elective surgery: a report of two cases. J Trauma; 2005 Sep;59(3):737-41
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  • [Title] Traumatic rupture of renal angiomyolipoma managed with angioembolization followed by elective surgery: a report of two cases.
  • [MeSH-major] Angiomyolipoma / complications. Angiomyolipoma / therapy. Elective Surgical Procedures. Embolization, Therapeutic. Kidney Neoplasms / complications. Kidney Neoplasms / therapy. Nephrectomy
  • [MeSH-minor] Accidents, Traffic. Adult. Algorithms. Aneurysm, Ruptured / radiography. Aneurysm, Ruptured / therapy. Angiography. Female. Humans. Middle Aged. Renal Artery. Rupture / radiography. Rupture / surgery. Tomography, X-Ray Computed

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  • (PMID = 16361922.001).
  • [ISSN] 0022-5282
  • [Journal-full-title] The Journal of trauma
  • [ISO-abbreviation] J Trauma
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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45. Prevoo W, van den Bosch MA, Horenblas S: Radiofrequency ablation for treatment of sporadic angiomyolipoma. Urology; 2008 Jul;72(1):188-91
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  • [Title] Radiofrequency ablation for treatment of sporadic angiomyolipoma.
  • INTRODUCTION: Symptomatic angiomyolipoma (AML) and asymptomatic AML larger than 4 cm in size are usually treated with nephron-sparing surgery or arterial embolization.
  • We used another technique, that is, radiofrequency ablation (RFA), for treatment of a sporadic AML in a patient with a solitary kidney, in whom maximal sparing of normal renal tissue was required.
  • TECHNICAL CONSIDERATIONS: Contrast-enhanced computed tomography (CT) showed an enhancing well-defined mainly lipomatous tumor, with a maximum diameter of 4.5 cm in the upper pole of the left kidney.
  • Diagnosis of AML was confirmed with fine-needle aspiration biopsy.
  • During follow-up (12 months) function of the solitary kidney of the patient was preserved and patient did not have any AML-related symptoms develop.
  • CONCLUSIONS: CT-guided RFA is a minimally invasive ablation procedure that allowed successful treatment of a sporadic AML in a patient with a solitary kidney.
  • [MeSH-major] Angiomyolipoma / surgery. Catheter Ablation. Kidney Neoplasms / surgery
  • [MeSH-minor] Aged. Humans. Kidney / abnormalities. Kidney / radiography. Male. Tomography, X-Ray Computed

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  • (PMID = 18455777.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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46. Phillips CK, Lepor H: Spontaneous retroperitoneal hemorrhage caused by segmental arterial mediolysis. Rev Urol; 2006;8(1):36-40
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  • Spontaneous retroperitoneal hemorrhage can be caused by tumors, such as renal cell carcinoma and angiomyolipoma; polyarteritis nodosa; and nephritis.
  • Although computed tomography is used for the diagnosis of spontaneous retroperitoneal hemorrhage, it can miss segmental arterial mediolysis as the cause of the hemorrhage.
  • The diagnosis of segmental arterial mediolysis as a cause of spontaneous retroperitoneal hemorrhage requires angiography, with pathologic confirmation for a definitive diagnosis.

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  • (PMID = 16985559.001).
  • [ISSN] 1523-6161
  • [Journal-full-title] Reviews in urology
  • [ISO-abbreviation] Rev Urol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1471764
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47. Pereverzev AS, Shchukin DV, Iliukhin IuA, Megera VV, Iaroslavskiĭ VL: [Spontaneous ruptures of renal tumors]. Urologiia; 2005 Mar-Apr;(2):21-4
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  • [Title] [Spontaneous ruptures of renal tumors].
  • For the last five years we treated 10 patients (7 females and 3 males) with spontaneous subcapsular or paranephral hematoma resultant from renal tumor rupture.
  • Morphologically, 4 tumors were renal angiomyolipoma and 6 tumors--renal cell carcinoma.
  • Left kidney tumor ruptures were more frequent (70%).
  • An accurate preoperative diagnosis was made in 70% cases with application of ultrasonic investigation, computed tomography, MR imaging, Of 4 patients with renal angiomyolipoma, conservative surgery (enucleation, enucleoresection) was conducted in 3 (75%) patients.
  • Of 6 patients with renal cell carcinoma, tumor removal with preservation of the kidney was feasible only in 1 (16.6%) patient, in the rest 5 patients radical nephrectomy was made.
  • Thus, patients with spontaneous rupture of renal tumors are characterized by absence of macrohematuria, prevalent location of the tumor on the left and in the middle segment of the kidney (90%), high diagnostic effectiveness of ultrasonography, no rise in local tumor recurrence consequently to rupture of the tumor tissue.
  • [MeSH-major] Angiomyolipoma / surgery. Carcinoma, Renal Cell / surgery. Hematoma / surgery. Kidney Neoplasms / surgery

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  • (PMID = 15989021.001).
  • [ISSN] 1728-2985
  • [Journal-full-title] Urologii︠a︡ (Moscow, Russia : 1999)
  • [ISO-abbreviation] Urologiia
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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48. Boorjian SA, Sheinin Y, Crispen PL, Lohse CM, Leibovich BC, Kwon ED: T-cell co-regulatory molecule expression in renal angiomyolipoma and pulmonary lymphangioleiomyomatosis. Urology; 2009 Dec;74(6):1359-64
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  • [Title] T-cell co-regulatory molecule expression in renal angiomyolipoma and pulmonary lymphangioleiomyomatosis.
  • OBJECTIVES: To investigate the expression of B7-H3 and B7-H1 in renal angiomyolipoma (AML) tumors and the related, devastating syndrome of pulmonary lymphangioleiomyomatosis (LAM).
  • We recently reported the high expression of T-cell co-regulatory B7-H ligands in renal cell carcinoma tumor vasculature and tumor cells.
  • AML is a highly vascular tumor that most frequently emanates from the kidney.
  • METHODS: Immunohistochemical methods were used to assess the tumor expression of B7-H1 and B7-H3 in paraffin-embedded tissues from 110 patients who had undergone partial or radical nephrectomy for renal AML and from 7 patients with LAM who had undergone lung biopsy.
  • B7-H3 staining was noted in a median of 90% (range 20%-100%) of cells from renal AMLs and was independent of patient age (P = .43), sex (P = .27), tumor size (P = .21), and symptomatic presentation (P = .35).
  • CONCLUSIONS: B7-H3 was expressed at high levels in renal AMLs and pulmonary LAM, and B7-H1 was infrequently expressed in these tumors.
  • [MeSH-major] Angiomyolipoma / metabolism. Antigens, CD / biosynthesis. Kidney Neoplasms / metabolism. Lung Neoplasms / metabolism. Lymphangioleiomyomatosis / metabolism. Receptors, Immunologic / biosynthesis. T-Lymphocytes / metabolism

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  • (PMID = 19501877.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01 CA134345; United States / NCI NIH HHS / CA / R01 CA134345-01A1
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD274; 0 / B7 Antigens; 0 / CD274 protein, human; 0 / CD276 protein, human; 0 / Receptors, Immunologic
  • [Other-IDs] NLM/ NIHMS160050; NLM/ PMC2789880
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49. Lu HC, Chau GY, Su CW: Clinical challenges and images in GI. Diagnosis: Hepatic angiomyolipoma mimicking hepatocellular carcinoma. Gastroenterology; 2009 Apr;136(4):1169, 1464
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  • [Title] Clinical challenges and images in GI. Diagnosis: Hepatic angiomyolipoma mimicking hepatocellular carcinoma.
  • [MeSH-major] Angiomyolipoma / diagnosis. Carcinoma, Hepatocellular / diagnosis. Liver Neoplasms / diagnosis
  • [MeSH-minor] Angiography. Biopsy, Fine-Needle. Diagnosis, Differential. Female. Hepatic Artery / radiography. Humans. Mesenteric Arteries / radiography. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 19254682.001).
  • [ISSN] 1528-0012
  • [Journal-full-title] Gastroenterology
  • [ISO-abbreviation] Gastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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50. Wang KL, Weinrach DM, Luan C, Han M, Lin F, Teh BT, Yang XJ: Renal papillary adenoma--a putative precursor of papillary renal cell carcinoma. Hum Pathol; 2007 Feb;38(2):239-46
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  • [Title] Renal papillary adenoma--a putative precursor of papillary renal cell carcinoma.
  • The precursor lesions of renal cell carcinoma (RCC) are unknown.
  • Seven papillary adenomas (18%) occurred in the setting of acquired polycystic kidney disease (APKD), 6 in clear-cell RCCs, 3 in chromophobe RCCs, 2 in end-stage kidney disease, 1 in oncocytoma, 1 in angiomyolipoma, and 1 in renal schwannoma.
  • Furthermore, papillary adenomas were more commonly found in kidneys removed for PRCC (25%, 18/71) than in kidneys harboring clear-cell RCC (1.9%, 6/318).
  • [MeSH-major] Carcinoma, Papillary / pathology. Carcinoma, Renal Cell / pathology. Kidney Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma, Clear Cell / enzymology. Adenocarcinoma, Clear Cell / pathology. Adenoma. Adenoma, Oxyphilic / enzymology. Adenoma, Oxyphilic / pathology. Adult. Aged. Aged, 80 and over. Angiomyolipoma / enzymology. Angiomyolipoma / pathology. Disease Progression. Female. Glutathione Transferase / analysis. Humans. Immunohistochemistry. Isoenzymes / analysis. Kidney / enzymology. Kidney / pathology. Kidney Failure, Chronic / enzymology. Kidney Failure, Chronic / pathology. Male. Middle Aged. Models, Biological. Polycystic Kidney Diseases / enzymology. Polycystic Kidney Diseases / pathology. Racemases and Epimerases / analysis

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  • (PMID = 17056094.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Isoenzymes; EC 2.5.1.18 / Glutathione Transferase; EC 2.5.1.18 / glutathione S-transferase alpha; EC 5.1.- / Racemases and Epimerases; EC 5.1.99.4 / alpha-methylacyl-CoA racemase
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51. Castagnetti M, Vezzù B, Laverda A, Zampieri S, Rigamonti W: Urological counseling and followup in pediatric tuberous sclerosis complex. J Urol; 2007 Nov;178(5):2155-9
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  • PURPOSE: We review our experience with renal manifestations in pediatric patients with the tuberous sclerosis complex, and offer recommendations for urological counseling, followup and treatment of these patients.
  • Patient data were gathered in a database focusing on renal involvement.
  • The risk of renal involvement was evaluated in relation to patient age, genotypic pattern and number of extrarenal manifestations.
  • RESULTS: Overall, 15 patients (36.6%) had renal involvement.
  • Angiomyolipomas were the most common lesions (11 patients), followed by renal cysts (2) and polycystic kidney disease (2).
  • Renal failure developed in the 2 patients with polycystic kidney disease by the 2nd decade of life.
  • Overall, treatment was required in 2 cases of symptomatic angiomyolipoma.
  • Both patients were female, and had multiple extrarenal manifestations and bilateral renal involvement.
  • Although most of the lesions remain silent during childhood, the incidence of renal involvement increases with age.
  • The need for treatment is highest in females with multiple extrarenal manifestations and bilateral renal involvement.
  • [MeSH-major] Counseling / methods. Kidney Diseases / therapy. Tuberous Sclerosis / therapy


52. Ameri C, Contreras P, Villasante N, Ríos Pita H, Richards N, Mazza O: [Solid renal mass up to 4 cm. Analysis of the diagnostic procedures, TNM staging and surgical treatment]. Actas Urol Esp; 2006 Sep;30(8):772-83
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  • [Title] [Solid renal mass up to 4 cm. Analysis of the diagnostic procedures, TNM staging and surgical treatment].
  • [Transliterated title] Masa ocupante renal sólida de hasta 4 cm: análisis de la metodología diagnóstica, estadificación TNM y tratamiento quirúrgico.
  • OBJECTIVES: We perform a retrospective review of renal tumors operated with a maximum size of 4 cm to determine if the diagnostic methodology was adequate, the TMN staging prognostic accuracy (UICC 2002) and the goal surgical treatment.
  • MATERIAL AND METHOD: Between 1984 to 2005, 78 renal units form 74 patients (4 bilateral synchronous) operated at the Service of Urology of the Hospital Alemán de Buenos Aires.
  • RESULTS: 78 renal units from a total of 192, 40.62% were analyzed.
  • The diagnosis was performing with ultrasound and CT scan 63 cases, in 4 was also used resonance magnetic imaging (RMI) and in 7 ultrasound and RMI.
  • Surgical treatment was radical surgery in 35 renal units (44.87%) and conservative surgery in 43 units (55.13%).
  • Pathology clear cells carcinoma (CCC) 79.48%, papillary carcinoma 1.28%, angiomyolipoma (AML) 8.97%, oncocytoma 7.69% and adenoma 2.56%.
  • CONCLUSIONS: 1)Ultrasound and CT scan obtained a highest diagnostic accuracy for solid renal mass.
  • [MeSH-major] Kidney Neoplasms / pathology. Kidney Neoplasms / surgery

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  • (PMID = 17078574.001).
  • [ISSN] 0210-4806
  • [Journal-full-title] Actas urologicas españolas
  • [ISO-abbreviation] Actas Urol Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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53. Pereverzev AS, Shchukin DV, Iliukhin IuA, Iaroslavskiĭ VL, Mys'ko SIa, Megera VV: [Renal tumors and pregnancy]. Urologiia; 2005 May-Jun;(3):3-6
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  • [Title] [Renal tumors and pregnancy].
  • The article presents a retrospective analysis of literature data on combination of renal tumors with pregnancy, three cases are reported.
  • Basic therapeutic algorithm of renal angiomyolipoma is follow-up.
  • [MeSH-major] Kidney Neoplasms / surgery. Kidney Neoplasms / ultrasonography. Nephrectomy. Pregnancy Complications, Neoplastic / surgery. Pregnancy Complications, Neoplastic / ultrasonography

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  • (PMID = 16100783.001).
  • [ISSN] 1728-2985
  • [Journal-full-title] Urologii︠a︡ (Moscow, Russia : 1999)
  • [ISO-abbreviation] Urologiia
  • [Language] rus
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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54. Katada Y, Umehara I, Ohki T, Kishino M, Shibuya H: Bilateral renal angiomyolipoma in a patient with tuberous sclerosis treated with resection of one kidney and transarterial embolization of other kidney using CT during selective arteriography: a case report. Cases J; 2009;2:6351
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  • [Title] Bilateral renal angiomyolipoma in a patient with tuberous sclerosis treated with resection of one kidney and transarterial embolization of other kidney using CT during selective arteriography: a case report.
  • Renal AML complicating tuberous sclerosis shows a rapid growth and its rupture is frequently associated with hemorrhagic shock as a result of profuse retroperitoneal bleeding, necessitating an aggressive therapeutic approach.
  • This report describes the long-term clinical progress of 28 year-old woman with tuberous sclerosis with a ruptured giant AML that underwent unilateral nephrectomy, who has been followed up after treatment with concomitant application of computed tomography during selective arteriography to conserve the remaining normal renal parenchyma, and in whom the need for initiation of dialysis has been successfully avoided, with conspicuous reduction of the tumor size.

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  • (PMID = 19829792.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2740105
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55. Liang SX, Pearl M, Liu J, Hwang S, Tornos C: "Malignant" uterine perivascular epithelioid cell tumor, pelvic lymph node lymphangioleiomyomatosis, and gynecological pecomatosis in a patient with tuberous sclerosis: a case report and review of the literature. Int J Gynecol Pathol; 2008 Jan;27(1):86-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Angiomyolipoma / complications. Angiomyolipoma / metabolism. Angiomyolipoma / pathology. Biomarkers, Tumor / analysis. Female. Humans. Immunohistochemistry. Kidney Neoplasms / pathology. Kidney Neoplasms / surgery. Lymph Nodes / metabolism. Lymph Nodes / pathology. Middle Aged. Nephrectomy. Pelvis / pathology. Skin Neoplasms / pathology


56. Habib SL: Insight into mechanism of oxidative DNA damage in angiomyolipomas from TSC patients. Mol Cancer; 2009;8:13
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  • TSC-2 gene encodes tuberin, a protein involved in the pathogenesis of kidney tumors, both angiomyolipomas and renal cell carcinomas.
  • Loss of heterozygosity at the 8-oxoG-DNA glycosylase (OGG1) allele is found in human kidney clear cell carcinoma identifying loss of OGG1 function as a possible contributor to tumorigenesis in the kidney.
  • The purpose of this study is to determine the effect of tuberin-deficiency on OGG1 protein and mRNA levels as well as on 8-oxodG levels in kidney tumors from patients with TSC.
  • In addition we evaluated the phophorylation level of downstream targets of mTOR, phospho-S70K, in kidney tumor tissue from TSC patients.
  • RESULTS: Kidney angiomyolipoma tissue from TSC patients expresses significant levels of phopho-tuberin and low levels of tuberin compared to control kidney tissue.
  • The increase in tuberin phosphorylation and the decrease tuberin expression are associated with decrease in OGG1 protein and mRNA levels in tumor samples compared to normal kidney samples.
  • Cyclin D1 expression is also 3-fold higher in increase in the tumor tissues compared to normal kidney tissues.
  • CONCLUSION: These data indicate that tuberin deficiency in angiomyolipoma enhances mTOR activation by phosphorylation of S6K and downregulation of protein and mRNA expression of OGG1 resulted in accumulation of oxidized DNA in patients with TSC.
  • These data suggest that tuberin and OGG1 are important proteins in the pathogenesis of angiomyolipoma in TSC patients.
  • [MeSH-major] Angiomyolipoma / genetics. Angiomyolipoma / metabolism. DNA Damage / physiology. DNA Glycosylases / metabolism. Tuberous Sclerosis / genetics. Tuberous Sclerosis / metabolism
  • [MeSH-minor] Animals. CCAAT-Binding Factor / metabolism. Cell Line. Cyclin D1 / metabolism. Deoxyguanosine / analogs & derivatives. Deoxyguanosine / metabolism. Humans. Immunoblotting. In Vitro Techniques. Kidney / metabolism. Kidney / pathology. Mice. Oxidative Stress. Phosphorylation. Protein Kinases / metabolism. Rats. Reverse Transcriptase Polymerase Chain Reaction. TOR Serine-Threonine Kinases. Tumor Suppressor Proteins / metabolism. Tumor Suppressor Proteins / physiology

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  • (PMID = 19265534.001).
  • [ISSN] 1476-4598
  • [Journal-full-title] Molecular cancer
  • [ISO-abbreviation] Mol. Cancer
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / P50 DK061597
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CCAAT-Binding Factor; 0 / NFYA protein, human; 0 / Tumor Suppressor Proteins; 136601-57-5 / Cyclin D1; 4JG2LF96VF / tuberous sclerosis complex 2 protein; 88847-89-6 / 8-oxo-7-hydrodeoxyguanosine; EC 2.7.- / Protein Kinases; EC 2.7.1.1 / MTOR protein, human; EC 2.7.1.1 / TOR Serine-Threonine Kinases; EC 2.7.1.1 / mTOR protein, mouse; EC 3.2.2.- / DNA Glycosylases; EC 3.2.2.- / oxoguanine glycosylase 1, human; G9481N71RO / Deoxyguanosine
  • [Other-IDs] NLM/ PMC2657104
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57. Belanger EC, Dhamanaskar PK, Mai KT: Epithelioid angiomyolipoma of the kidney mimicking renal sarcoma. Histopathology; 2005 Oct;47(4):433-5
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  • [Title] Epithelioid angiomyolipoma of the kidney mimicking renal sarcoma.
  • [MeSH-major] Angiomyolipoma / pathology. Epithelioid Cells / pathology. Kidney Neoplasms / pathology
  • [MeSH-minor] Antigens, Neoplasm. Carcinosarcoma / metabolism. Carcinosarcoma / pathology. Diagnosis, Differential. Humans. Immunohistochemistry. Melanoma-Specific Antigens. Neoplasm Proteins / metabolism. Sarcoma / metabolism. Sarcoma / pathology

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  • (PMID = 16178901.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins
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58. Sukumar S, Balagopal Nair T, Mohammed Saheed CS, Sanjay Bhat H: Bilateral nephron sparing surgeries for multiple renal angiomyolipomas in Bourneville's disease. Int Urol Nephrol; 2007;39(2):389-91
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  • [Title] Bilateral nephron sparing surgeries for multiple renal angiomyolipomas in Bourneville's disease.
  • INTRODUCTION: Angiomyolipomas are the most common renal lesions in tuberous sclerosis complex.
  • CASE-HISTORY: A 22-year-old lady with bilateral multiple large symptomatic renal angiomyolipomas associated with other manifestations of tuberous sclerosis was managed with partial nephrectomies on either side.
  • At 30 months of follow-up, the patient has normal renal functions and no evidence of recurrence.
  • DISCUSSION: Intervention for renal angiomyolipomas is indicated in symptomatic tumors larger than four centimetres.
  • Nephron sparing surgery of both kidneys for angiomyolipomas in association with tuberous sclerosis has only been sparingly reported in literature.
  • [MeSH-major] Angiomyolipoma / surgery. Kidney Neoplasms / surgery. Nephrectomy / methods. Tuberous Sclerosis / complications

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  • (PMID = 17004032.001).
  • [ISSN] 0301-1623
  • [Journal-full-title] International urology and nephrology
  • [ISO-abbreviation] Int Urol Nephrol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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59. Yamashita R, Nakamura M, Matsuzaki M, Matsui T, Yamaguchi R, Niwakawa M, Tobisu K, Asakura K, Ito I: [Clinical factors associated with benign renal tumors]. Nihon Hinyokika Gakkai Zasshi; 2009 Nov;100(7):679-85
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  • [Title] [Clinical factors associated with benign renal tumors].
  • OBJECTIVES: In this study, we sought to define the incidence of benign renal tumors in our institute and to clarify the clinical factors associated with benign renal tumors, in order to assist in forming preoperative differential diagnoses.
  • METHODS: From October 2002 to July 2007, we performed 157 nephrectomies in patients preoperatively diagnosed with renal cell carcinoma.
  • We also compared clinical factors, including age, sex and tumor size, between the benign and malignant renal tumors.
  • Benign renal tumors were found in 10 (12%) of the 81 tumors; these included seven cases of oncocytoma and three cases of angiomyolipoma with minimal fat.
  • Several factors were significant clinical determinants of differentiation between benign and malignant renal tumors: homogeneity in CT, female gender, and small tumor size all predominated in cases of benign tumors.
  • CONCLUSIONS: When a patient, especially a female, presents with a small and homogeneous renal tumor, careful consideration should be given to the possibility of a benign process, which needs further consideration before performing excessive surgery.
  • [MeSH-major] Adenoma, Oxyphilic. Angiomyolipoma. Kidney Neoplasms
  • [MeSH-minor] Age Factors. Aged. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Retrospective Studies. Sex Factors. Tomography, Spiral Computed

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  • (PMID = 19999132.001).
  • [ISSN] 0021-5287
  • [Journal-full-title] Nihon Hinyōkika Gakkai zasshi. The japanese journal of urology
  • [ISO-abbreviation] Nippon Hinyokika Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Japan
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60. Sutter R, Boehler A, Willmann JK: Adrenal angiomyolipoma in lymphangioleiomyomatosis. Eur Radiol; 2007 Feb;17(2):565-6
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  • [Title] Adrenal angiomyolipoma in lymphangioleiomyomatosis.
  • [MeSH-major] Adrenal Gland Neoplasms / secondary. Angiomyolipoma / pathology. Lymphangioleiomyomatosis / pathology

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  • [Cites] Radiology. 2000 Jul;216(1):147-53 [10887241.001]
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  • (PMID = 16586050.001).
  • [ISSN] 0938-7994
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Germany
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61. Larrea JS, Pino LB, Cabrera RS, Mena AL: Urological conservative management of a patient with tuberous sclerosis complex (Bourneville disease). Arch Esp Urol; 2009 Sep;62(7):596-9
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  • OBJECTIVE: To report the clinical and radiological data of a 23-year-woman with bilateral angiomyolipoma and Tuberous Sclerosis with conservative treatment.
  • CONCLUSIONS: Renal lesions associated with tuberous sclerosis are frequent and serious.
  • Monitoring should be based on a careful monitoring since the renal lesions are the second death cause after the lesions of the nervous system.
  • [MeSH-major] Angiomyolipoma / therapy. Kidney Neoplasms / therapy. Tuberous Sclerosis / complications


62. Koh JL, Lee YH, Kang CY, Lin CN: Simultaneous cesarean section and radical nephrectomy for angiomyolipoma with spontaneous bleeding during pregnancy: a case report. J Reprod Med; 2007 Apr;52(4):338-40
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  • [Title] Simultaneous cesarean section and radical nephrectomy for angiomyolipoma with spontaneous bleeding during pregnancy: a case report.
  • BACKGROUND: Renal angiomyolipoma with spontaneous bleeding during pregnancy is an extremely rare condition and may jeopardize both the mother and fetus.
  • The ethics of reproductive medicine, method of diagnosis, option for management and optimal time for surgical intervention can be arguable in this situation.
  • Abdominal sonography and renal magnetic resonance imaging revealed a hypervascular and fat-containing mass with mother and fetus bleeding at the right kidney.
  • Angiomyolipoma of the right kidney was diagnosed on pathologic examination.
  • CONCLUSION: Renal angiomyolipoma with spontaneous bleeding during pregnancy is a dangerous condition that may cause mortality in the mother and fetus, but elective, simultaneous cesarean section and radical nephrectomy can be performed safely if the hemodynamic status is stable.
  • [MeSH-major] Angiomyolipoma / surgery. Cesarean Section / methods. Kidney Neoplasms / surgery. Nephrectomy / methods. Pregnancy Complications, Neoplastic / surgery


63. Shi H, Cao D, Wei L, Sun L, Guo A: Inflammatory angiomyolipomas of the liver: a clinicopathologic and immunohistochemical analysis of 5 cases. Ann Diagn Pathol; 2010 Aug;14(4):240-6
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  • Hepatic angiomyolipoma (AML) may demonstrate a marked histologic diversity.
  • [MeSH-major] Angiomyolipoma / pathology. Liver Neoplasms / pathology

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20637427.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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64. Katayama K, Hayashi T, Tsutahara K, Matsuoka A, Fujimoto N, Koide T: [Bilateral giant renal angiomyolipoma following hemodialysis in a patient with tuberous sclerosis]. Hinyokika Kiyo; 2009 Jun;55(6):335-8
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  • [Title] [Bilateral giant renal angiomyolipoma following hemodialysis in a patient with tuberous sclerosis].
  • She had been diagnosed with bilateral renal angiomyolipoma (AML) when she was 32 years old and had been on maintenance hemodialysis since the age of 44.
  • Magnetic resonance imaging showed bilateral giant renal AML and hemorrhage in the AML of the left kidney.
  • The histological diagnosis was consistent with AML.
  • In addition, the Japanese literature on giant renal AML was reviewed and discussed.
  • [MeSH-major] Angiomyolipoma / etiology. Kidney Neoplasms / etiology. Renal Dialysis. Tuberous Sclerosis / complications


65. Schuetz AN, Yin-Goen Q, Amin MB, Moreno CS, Cohen C, Hornsby CD, Yang WL, Petros JA, Issa MM, Pattaras JG, Ogan K, Marshall FF, Young AN: Molecular classification of renal tumors by gene expression profiling. J Mol Diagn; 2005 May;7(2):206-18
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  • [Title] Molecular classification of renal tumors by gene expression profiling.
  • Renal tumor classification is important because histopathological subtypes are associated with distinct clinical behavior.
  • However, diagnosis is difficult because tumor subtypes have overlapping microscopic characteristics.
  • We used oligonucleotide microarrays to analyze 31 adult renal tumors, including clear cell renal cell carcinoma (RCC), papillary RCC, chromophobe RCC, oncocytoma, and angiomyolipoma.
  • Clear cell RCC overexpressed proximal nephron, angiogenic, and immune response genes, chromophobe RCC oncocytoma overexpressed distal nephron and oxidative phosphorylation genes, papillary RCC overexpressed serine protease inhibitors, and extracellular matrix products, and angiomyolipoma overexpressed muscle developmental, lipid biosynthetic, melanocytic, and distinct angiogenic factors.
  • Quantitative reverse transcriptase-polymerase chain reaction and immunohistochemistry of formalin-fixed renal tumors confirmed overexpression of proximal nephron markers (megalin/low-density lipoprotein-related protein 2, alpha-methylacyl CoA racemase) in clear cell and papillary RCC and distal nephron markers (beta-defensin 1, claudin 7) in chromophobe RCC/oncocytoma.
  • In summary, renal tumor subtypes were classified by distinct gene expression profiles, illustrating tumor pathobiology and translating into novel molecular bioassays using fixed tissue.
  • [MeSH-major] Gene Expression Profiling. Kidney Neoplasms / classification. Oligonucleotide Array Sequence Analysis

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  • (PMID = 15858144.001).
  • [ISSN] 1525-1578
  • [Journal-full-title] The Journal of molecular diagnostics : JMD
  • [ISO-abbreviation] J Mol Diagn
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1867531
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66. Ben Hamida F, Gorsane I, Gharbi C, Kaaroud H, Barbouch S, Smaoui W, Helal I, Beji S, Goucha R, Hedri H, Ben Moussa F, Ben Abdallah T, Ben Maiz H, Kheder A: [Renal manifestations in tuberous sclerosis]. Rev Med Interne; 2006 Nov;27(11):836-42
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  • [Title] [Renal manifestations in tuberous sclerosis].
  • Renal involvement is one of the most severe manifestations of the disease.
  • We analysed in this study renal involvement of tuberous sclerosis.
  • METHODS: We studied retrospectively nine cases of tuberous sclerosis with renal involvement diagnosed between 1994 and 2005.
  • The diagnosis was based on the presence of typical extra-renal manifestations and familial history of tuberous sclerosis.
  • At first presentation, we noted hypertension in three cases, proteinuria in seven cases, hematuria in eight cases and renal failure in five cases (end stage renal failure in four cases).
  • By ultrasonography, we found angiomyolipoma in one case, cysts in four cases and angiomyolipoma associated to cysts in four cases.
  • In the later, pathological examination revealed renal carcinoma.
  • At last evaluation, two patients were lost to follow-up, one had normal serum creatinine, five were on renal replacement therapy and the latter died from sepsis following kidney removal.
  • CONCLUSIONS: In our patients, renal disease was diagnosed late at chronic renal failure stage.
  • Patients with end-stage renal failure require dialysis and renal transplantation, but we recommend binephrectomy after starting dialysis and before transplantation due to the risk of cancer and bleeding related to angiomyolipomas.


67. Takanami K, Kaneta T, Hitachi S, Yamada T, Ishida K, Rikiyama T, Katayose Y, Unno M, Yamada S, Takahashi S: F-18 FDG PET/CT findings in two patients with hepatic angiomyolipoma with and without intratumoral hemorrhage. Clin Nucl Med; 2010 Jan;35(1):18-21
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  • [Title] F-18 FDG PET/CT findings in two patients with hepatic angiomyolipoma with and without intratumoral hemorrhage.
  • [MeSH-major] Angiomyolipoma / diagnosis. Fluorodeoxyglucose F18. Hemorrhage / radionuclide imaging. Liver Neoplasms / diagnosis. Positron-Emission Tomography / methods. Tomography, X-Ray Computed / methods

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  • (PMID = 20026966.001).
  • [ISSN] 1536-0229
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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68. Suzuki T, Ueda Y, Shincho M, Mitsui Y, Higuchi Y, Maruyama T, Kondoh N, Nojima M, Yamamoto S, Hirota S, Shima H: [Myolipoma arising from the renal capsule: a case report]. Hinyokika Kiyo; 2008 May;54(5):349-52
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  • [Title] [Myolipoma arising from the renal capsule: a case report].
  • A 53-year-old female visited us with an asymptomatic renal mass, which was incidentally found on abdominal ultrasonography (US).
  • US showed a heterogeneous renal mass measuring 5 cm in diameter.
  • Computed tomorraphy and magnetic resonance imaging showed that the tumor was mixed with muscle and fat tissue, faintly enhanced, and located at the lower portion of the left kidney.
  • Although renal angiomyolipoma (AML) was suspected from these findings, we could not rule out a malignant tumor.
  • Histopathological examination revealed the tumor composed of smooth muscle and mature adipose tissue without cytological atypia arising from the renal capsule.
  • The final diagnosis was myolipoma arising from the renal capsule.
  • [MeSH-major] Kidney Neoplasms / diagnosis. Lipoma / diagnosis

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  • (PMID = 18546859.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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69. Linder B, Hong Y, Jarrett T: Intra-renal adrenal adenoma: a compelling addition to the differential diagnosis of renal mass. Int J Urol; 2009 Nov;16(11):912-4
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  • [Title] Intra-renal adrenal adenoma: a compelling addition to the differential diagnosis of renal mass.
  • We report a case of an adrenal rest arising in the kidney of a 37-year-old male.
  • Laparoscopic renal exploration and biopsy revealed angiomyolipoma on frozen section.
  • However, final pathological analysis of the partial nephrectomy specimen revealed intra-renal adrenal adenoma.
  • The diagnosis was confirmed by immunohistochemistries and transmission electron microscopy.
  • We review the reported literature on intra-renal adrenal adenoma and highlight the aspects that raise the index of suspicion for this entity on the differential diagnosis of renal masses.
  • [MeSH-major] Adenoma / diagnosis. Adrenal Gland Neoplasms / diagnosis. Kidney Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male. Neoplasm Invasiveness

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  • (PMID = 19863627.001).
  • [ISSN] 1442-2042
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Australia
  • [Number-of-references] 8
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70. Israel GM, Hindman N, Hecht E, Krinsky G: The use of opposed-phase chemical shift MRI in the diagnosis of renal angiomyolipomas. AJR Am J Roentgenol; 2005 Jun;184(6):1868-72
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  • [Title] The use of opposed-phase chemical shift MRI in the diagnosis of renal angiomyolipomas.
  • OBJECTIVE: The objective of our study was to determine the reliability of the location of the india ink artifact and signal loss on opposed-phase chemical shift MRI to differentiate angiomyolipomas from solid renal masses and from hemorrhagic-proteinaceous renal cysts.
  • MATERIALS AND METHODS: Twenty-three angiomyolipomas, 24 hemorrhagic-proteinaceous cysts, and 23 solid renal masses (nonangiomyolipomas) were retrospectively evaluated at 1.5 T with chemical shift MRI using TEs of 2.1-2.7 msec (opposed phase) and 4.8-5.3 msec (in phase).
  • An angiomyolipoma was diagnosed if the india ink artifact was identified at the interface of the mass and the kidney or was present within the renal mass.
  • RESULTS: Twenty-three (100%) of the 23 angiomyolipomas showed india ink artifact within the mass or at its interface with the kidney, and 18 (78.3%) of the 23 angiomyolipomas showed signal loss on opposed-phase MR images.
  • In 24 (100%) of the 24 hemorrhagic-proteinaceous cysts, india ink artifact was not present within the mass or at its interface with the kidney.
  • In one (4%) of the 23 solid (nonangiomyolipoma) renal masses, the india ink artifact was identified at the interface of the mass with the kidney, and in two (9%) of the 23 masses, loss of signal was identified on the opposed-phase MR images.
  • CONCLUSION: The presence of india artifact at a renal mass-kidney interface or within a renal mass is indicative of angiomyolipoma.
  • [MeSH-major] Angiomyolipoma / diagnosis. Kidney Neoplasms / diagnosis. Magnetic Resonance Imaging
  • [MeSH-minor] Aged. Artifacts. Carbon. Female. Humans. Ink. Kidney / pathology. Kidney Diseases, Cystic / diagnosis. Male. Retrospective Studies

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  • (PMID = 15908544.001).
  • [ISSN] 0361-803X
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / chinese ink; 7440-44-0 / Carbon
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71. Adachi Y, Horie Y, Kitamura Y, Nakamura H, Taniguchi Y, Miwa K, Fujioka S, Nishimura M, Hayashi K: CD1a expression in PEComas. Pathol Int; 2008 Mar;58(3):169-73
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  • Nineteen PEComas were obtained, which included angiomyolipoma of the kidney or liver, lymphangiomyomatosis of the uterus or lung and clear cell sugar tumor of the lung.

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  • (PMID = 18251780.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antigens, CD1; 0 / Biomarkers, Tumor; 0 / CD1a antigen
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72. Schachter LR, Cookson MS, Chang SS, Smith JA Jr, Dietrich MS, Jayaram G, Herrell SD: Second prize: frequency of benign renal cortical tumors and histologic subtypes based on size in a contemporary series: what to tell our patients. J Endourol; 2007 Aug;21(8):819-23
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  • [Title] Second prize: frequency of benign renal cortical tumors and histologic subtypes based on size in a contemporary series: what to tell our patients.
  • BACKGROUND AND PURPOSE: Historically, 85% to 90% of renal masses have been malignant, with the majority being renal-cell carcinoma.
  • However, with the increasing frequency of incidentally discovered renal masses, only 70% to 85% of lesions are found to be malignant.
  • This study sought to determine the incidence of the various histologic subtypes of renal cortical tumors according to size in a contemporary series of surgically treated patients.
  • MATERIALS AND METHODS: Our prospectively collected database of all 482 patients who underwent partial or radical nephrectomy for a unilateral, unifocal, suspicious renal cortical tumor between January 2001 and October 2005 was reviewed.
  • CONCLUSIONS: This study examined the largest contemporary database evaluating the histologic type of renal lesions according to size.
  • Given the differences in the biological behavior of the various histologic subtypes of these tumors, these data are important when counseling patients about the treated and untreated natural history of small renal masses.

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  • (PMID = 17867935.001).
  • [ISSN] 0892-7790
  • [Journal-full-title] Journal of endourology
  • [ISO-abbreviation] J. Endourol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
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73. Rotman S, Déruaz C, Venetz JP, Chaubert P, Benhattar J, Meuwly JY, Jichlinski P, Guillou L, Moll S, Pascual M, Lemoine R: De novo concurrent papillary renal cell carcinoma and angiomyolipoma in a kidney allograft: evidence of donor origin. Hum Pathol; 2006 Apr;37(4):481-7
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  • [Title] De novo concurrent papillary renal cell carcinoma and angiomyolipoma in a kidney allograft: evidence of donor origin.
  • In the general population, renal cell carcinoma (RCC) is a relatively common neoplasm; however, the papillary RCC subtype is infrequent and represents only 10 to 15% of all RCC.
  • Angiomyolipoma is a well-known common benign tumor.
  • The occurrence of RCC in association with angiomyolipoma is a rare event, with only approximately 50 cases reported in the nontransplantation setting.
  • In transplant recipients, RCC can develop in native kidneys, but its occurrence "de novo" in the renal allograft is very rare with an estimated incidence of less than 0.5%.
  • We report here the case of a 39-year-old woman who underwent cadaveric renal transplantation in 1990.
  • She underwent allograft nephrectomy and the histologic findings revealed that one of the tumors was a chromophilic (type 1) papillary RCC (2.5 cm in diameter) and the other, an angiomyolipoma (1.5 cm).
  • To our knowledge, this is the first report of de novo concurrent papillary RCC and angiomyolipoma in a renal allograft.
  • [MeSH-major] Angiomyolipoma / etiology. Carcinoma, Renal Cell / etiology. Kidney Neoplasms / etiology. Kidney Transplantation / adverse effects. Tissue Donors


74. Siroky BJ, Czyzyk-Krzeska MF, Bissler JJ: Renal involvement in tuberous sclerosis complex and von Hippel-Lindau disease: shared disease mechanisms? Nat Clin Pract Nephrol; 2009 Mar;5(3):143-56
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  • [Title] Renal involvement in tuberous sclerosis complex and von Hippel-Lindau disease: shared disease mechanisms?
  • Tuberous sclerosis complex and von Hippel-Lindau disease are distinct autosomal dominant tumor suppressor syndromes that can exhibit similar renal phenotypes and seem to share some signaling pathway components.
  • [MeSH-major] Kidney Diseases, Cystic / genetics. Kidney Neoplasms / genetics. Tuberous Sclerosis / genetics. von Hippel-Lindau Disease / genetics
  • [MeSH-minor] Adenoma, Oxyphilic / genetics. Angiomyolipoma / genetics. Carcinoma, Renal Cell / genetics. Cell Proliferation. Humans. Hypoxia-Inducible Factor 1 / metabolism. Signal Transduction. Tumor Suppressor Proteins / metabolism

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  • (PMID = 19240728.001).
  • [ISSN] 1745-8331
  • [Journal-full-title] Nature clinical practice. Nephrology
  • [ISO-abbreviation] Nat Clin Pract Nephrol
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA122346; United States / NIDDK NIH HHS / DK / DK061458; United States / PHS HHS / / DODPR064135; United States / PHS HHS / / DODTS050008
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Hypoxia-Inducible Factor 1; 0 / Tumor Suppressor Proteins
  • [Number-of-references] 148
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75. El-Hashemite N, Walker V, Kwiatkowski DJ: Estrogen enhances whereas tamoxifen retards development of Tsc mouse liver hemangioma: a tumor related to renal angiomyolipoma and pulmonary lymphangioleiomyomatosis. Cancer Res; 2005 Mar 15;65(6):2474-81
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  • [Title] Estrogen enhances whereas tamoxifen retards development of Tsc mouse liver hemangioma: a tumor related to renal angiomyolipoma and pulmonary lymphangioleiomyomatosis.
  • Pulmonary lymphangioleiomyomatosis and abdominal angiomyolipoma are related lesions for which there is no authentic animal model.
  • We found that the Tsc mouse liver hemangioma are composed predominantly of endothelial cells but with a smooth muscle component, and express HMB45 antigen, estrogen receptor, and progesterone receptor, similar to lymphangioleiomyomatosis and angiomyolipoma.
  • These mouse model observations indicate the importance of estrogen signaling in vivo for the growth of tuberous sclerosis lesions, suggesting the possible benefits of tamoxifen therapy for the treatment of angiomyolipoma and lymphangioleiomyomatosis.
  • [MeSH-minor] Angiomyolipoma / genetics. Angiomyolipoma / pathology. Animals. Cystadenoma / genetics. Cystadenoma / pathology. Female. Kidney Neoplasms. Lung Neoplasms / genetics. Lung Neoplasms / pathology. Lymphangioleiomyomatosis / genetics. Lymphangioleiomyomatosis / pathology. Mice. Neovascularization, Pathologic / metabolism. Neovascularization, Pathologic / pathology. Vascular Endothelial Growth Factor A / biosynthesis

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  • (PMID = 15781664.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Grant] United States / NINDS NIH HHS / NS / NS24279; United States / NINDS NIH HHS / NS / NS31535
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Repressor Proteins; 0 / Tumor Suppressor Proteins; 0 / Vascular Endothelial Growth Factor A; 0 / tuberous sclerosis complex 1 protein; 094ZI81Y45 / Tamoxifen; 4JG2LF96VF / tuberous sclerosis complex 2 protein; 4TI98Z838E / Estradiol
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76. Ramírez Daniel L, García Sabela L, Rey Jorge R, Calvo Antonio O: [Retroperitoneal angiomyolipoma: review of the literature and report of a new case]. Actas Urol Esp; 2010 Oct;34(9):815-7
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  • [Title] [Retroperitoneal angiomyolipoma: review of the literature and report of a new case].
  • [Transliterated title] Angiomiolipoma retroperitoneal: revisión de la literatura y reporte de un nuevo caso.
  • [MeSH-major] Angiomyolipoma. Puerperal Disorders. Retroperitoneal Neoplasms

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  • (PMID = 20843462.001).
  • [ISSN] 1699-7980
  • [Journal-full-title] Actas urologicas españolas
  • [ISO-abbreviation] Actas Urol Esp
  • [Language] spa
  • [Publication-type] Case Reports; Letter; Review
  • [Publication-country] Spain
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77. Chang MH, Yao-Peng H: Lymphangioleiomyomatosis, multifocal micronodular pneumocyte hyperplasia, and clear-cell micronodules in a 39-year-old woman with tuberous sclerosis: a case report. Int J Surg Pathol; 2010 Dec;18(6):522-5
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  • Bilateral renal angiomyolipomas (AMLs) and cerebral periventricular spots were also present.
  • [MeSH-minor] Adult. Angiomyolipoma / complications. Angiomyolipoma / pathology. Female. Humans. Hyperplasia / complications. Hyperplasia / pathology. Kidney Neoplasms / complications. Kidney Neoplasms / pathology. Perivascular Epithelioid Cell Neoplasms / complications. Perivascular Epithelioid Cell Neoplasms / pathology


78. Iarrobino G, Capasso L, Buonincontro S, Alderisio A, Sciano D, Calabrese R, Borsi E: [Preservative surgery of the kidney for haemorrhagic angiomyolipoma: a report of two cases]. Chir Ital; 2008 Jul-Aug;60(4):587-93
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  • [Title] [Preservative surgery of the kidney for haemorrhagic angiomyolipoma: a report of two cases].
  • [Transliterated title] Chirurgia conservativa del parenchima renale per angiomiolipoma emorragico: due casi clinici.
  • Renal angiomyolipomas are very rare benign tumours (3% of renal tumours) that may present as isolated tumours or tumours associated with other pathologies, particularly tuberous sclerosis (40%), neurofibro-matosis, or Sturge-Webers disease.
  • Clinically, renal angiomyolipoma is asymptomatic until the tumour becomes larger than 4 cm, causing urinary symptoms such as pain, infection, and microhaematuria.
  • On the basis of case reports starting with haemorrhage and treated in urgency and of a review of the literature, we conclude that it is possible and mandatory to perform emergency preservative treatments of the kidney with an angiographic or surgical approach, and to ensure haemostasis.
  • [MeSH-major] Angiomyolipoma / surgery. Kidney Neoplasms / surgery. Nephrectomy / methods

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  • (PMID = 18837263.001).
  • [ISSN] 0009-4773
  • [Journal-full-title] Chirurgia italiana
  • [ISO-abbreviation] Chir Ital
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
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79. Morton JM, McLean C, Booth SS, Snell GI, Whitford HM: Regression of pulmonary lymphangioleiomyomatosis (PLAM)-associated retroperitoneal angiomyolipoma post-lung transplantation with rapamycin treatment. J Heart Lung Transplant; 2008 Apr;27(4):462-5
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  • [Title] Regression of pulmonary lymphangioleiomyomatosis (PLAM)-associated retroperitoneal angiomyolipoma post-lung transplantation with rapamycin treatment.
  • Computed tomography (CT) scan demonstrated no pulmonary abnormality, but identified a retroperitoneal mass confirmed as angiomyolipoma by CT-guided core biopsy.
  • Based on experimental work that rapamycin may inhibit angiomyolipoma cells, we commenced the patient on low-dose rapamycin.
  • [MeSH-major] Angiomyolipoma / drug therapy. Antibiotics, Antineoplastic / therapeutic use. Lung Neoplasms / surgery. Lung Transplantation. Lymphangioleiomyomatosis / surgery. Neoplasms, Second Primary. Retroperitoneal Neoplasms / drug therapy. Sirolimus / therapeutic use

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  • [CommentIn] J Heart Lung Transplant. 2008 Nov;27(11):1268 [18971103.001]
  • (PMID = 18374885.001).
  • [ISSN] 1557-3117
  • [Journal-full-title] The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
  • [ISO-abbreviation] J. Heart Lung Transplant.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; W36ZG6FT64 / Sirolimus
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80. Green DE, Woodward PJ: The management of indeterminate incidental findings detected at abdominal CT. Semin Ultrasound CT MR; 2005 Feb;26(1):2-13
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  • Some of these findings can be characterized without additional imaging (including simple renal cyst, angiomyolipoma, hepatic steatosis).
  • While some of these indeterminate incidental findings can be ignored based on statistical arguments (for example, a sharply circumscribed homogeneous low-attenuation renal lesion under 1 cm in patients without a predisposition to develop renal cell carcinoma), many may need additional imaging studies to either characterize them or demonstrate stability over time.
  • [MeSH-major] Abdominal Neoplasms / diagnosis. Abdominal Neoplasms / therapy. Digestive System Diseases / diagnosis. Digestive System Diseases / therapy. Incidental Findings. Radiography, Abdominal / methods
  • [MeSH-minor] Aortic Aneurysm / diagnosis. Aortic Aneurysm / therapy. Cysts / diagnosis. Cysts / therapy. Digestive System / radiography. Humans. Tomography, X-Ray Computed / methods

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  • (PMID = 15771259.001).
  • [ISSN] 0887-2171
  • [Journal-full-title] Seminars in ultrasound, CT, and MR
  • [ISO-abbreviation] Semin. Ultrasound CT MR
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 60
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81. Pan CC, Chung MY, Ng KF, Liu CY, Wang JS, Chai CY, Huang SH, Chen PC, Ho DM: Constant allelic alteration on chromosome 16p (TSC2 gene) in perivascular epithelioid cell tumour (PEComa): genetic evidence for the relationship of PEComa with angiomyolipoma. J Pathol; 2008 Feb;214(3):387-93
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Constant allelic alteration on chromosome 16p (TSC2 gene) in perivascular epithelioid cell tumour (PEComa): genetic evidence for the relationship of PEComa with angiomyolipoma.
  • Perivascular epithelioid cell tumours (PEComas) are a family of tumours including classic angiomyolipoma, lymphangioleiomyomatosis, and clear epithelioid cell tumours reported under a variety of names such as epithelioid angiomyolipoma, pulmonary and extrapulmonary clear cell sugar tumour, and PEComa.
  • We collected ten sporadic and two tuberous sclerosis complex-associated PEComas, as well as 14 sporadic classic hepatic and renal angiomyolipomas (AMLs) as controls.
  • Our observations of frequent deletion of TSC2 and the mTOR signalling pathway provide evidence that the oncogenetic lineage of PEComa, as a distinct TSC2-linked neoplasm, is similar to that of angiomyolipoma.
  • [MeSH-major] Angiomyolipoma / genetics. Biomarkers, Tumor. Kidney Neoplasms / genetics. Tumor Suppressor Proteins / genetics


82. Zhou YM, Li B, Xu F, Wang B, Li DQ, Zhang XF, Liu P, Yang JM: Clinical features of hepatic angiomyolipoma. Hepatobiliary Pancreat Dis Int; 2008 Jun;7(3):284-7
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  • [Title] Clinical features of hepatic angiomyolipoma.
  • BACKGROUND: Hepatic angiomyolipoma (HAML) is a rare hepatic mesenchymal tumor.
  • Pre-operative diagnosis was made in only 3 patients.
  • CONCLUSIONS: Pre-operative diagnosis of HAML is difficult.
  • [MeSH-major] Angiomyolipoma / pathology. Hepatectomy / methods. Liver Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Antigens, Neoplasm / metabolism. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Immunohistochemistry. Male. Melanoma-Specific Antigens. Middle Aged. Neoplasm Proteins / metabolism. Neoplasm Staging. Prognosis. Retrospective Studies

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  • (PMID = 18522883.001).
  • [ISSN] 1499-3872
  • [Journal-full-title] Hepatobiliary & pancreatic diseases international : HBPD INT
  • [ISO-abbreviation] HBPD INT
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins
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83. Luo DL, Liu YH, Zhuang HG, Luo XL: [Tumors showing perivascular epithelioid cell differentiation: a clinicopathologic study of 39 cases]. Zhonghua Yi Xue Za Zhi; 2007 Nov 6;87(41):2909-13
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  • METHODS: The clinicopathologic data of 39 cases pf angiomyolipoma (AML), 17 males and 22 females, with the primary focus in the kidney on 30 cases, in the liver in 4 cases, in the lung, uterus and broad ligament, abdominal wall, retroperitoneum, and nasal cavity in 1 case respectively, were analyzed.
  • RESULTS: Pathological examination showed branched capillaries or arterioles, often thick-walled similar to those in the renal cell carcinoma, and the cancerous cells consisting of the mixture of epithelial cells and spindle cells.
  • [MeSH-major] Angiomyolipoma / pathology. Epithelioid Cells / pathology. Kidney Neoplasms / pathology

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  • (PMID = 18261305.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Desmin; 0 / S100 Proteins; 0 / Vimentin; 68238-35-7 / Keratins; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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84. Dillon RC, Friedman AC, Miller FH: MR signal intensity calculations are not reliable for differentiating renal cell carcinoma from lipid poor angiomyolipoma. Radiology; 2010 Oct;257(1):299-300; author reply 300
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  • [Title] MR signal intensity calculations are not reliable for differentiating renal cell carcinoma from lipid poor angiomyolipoma.
  • [MeSH-major] Angiomyolipoma / pathology. Carcinoma, Renal Cell / pathology. Kidney Neoplasms / pathology. Magnetic Resonance Imaging / methods
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Middle Aged


85. Sato K, Ueda Y, Tachibana H, Miyazawa K, Chikazawa I, Kaji S, Nojima T, Katsuda S: Malignant epithelioid angiomyolipoma of the kidney in a patient with tuberous sclerosis: an autopsy case report with p53 gene mutation analysis. Pathol Res Pract; 2008;204(10):771-7
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  • [Title] Malignant epithelioid angiomyolipoma of the kidney in a patient with tuberous sclerosis: an autopsy case report with p53 gene mutation analysis.
  • We report an autopsy case of malignant epithelioid angiomyolipoma in a 36-year-old male tuberous sclerosis patient.
  • He had been diagnosed to have a bilateral renal tumor 20 years previously.
  • The left kidney had been surgically resected at the age of 34, and the left renal tumor was pathologically diagnosed as classic angiomyolipoma and epithelioid angiomyolipoma.
  • He suddenly died of cardiac arrest, and at autopsy the right kidney weighed 7120 g.
  • Immunohistochemical examination showed epithelioid angiomyolipoma cells that were focally reactive for HMB-45 and showed diffuse positive staining for Melan-A.
  • This case was proven to be malignant because of the occurrence of distant metastases, and showed that p53 mutations are not always associated with malignant transformation in epithelioid angiomyolipoma.
  • [MeSH-major] Angiomyolipoma / genetics. DNA Mutational Analysis. Epithelioid Cells / pathology. Gene Expression Regulation, Neoplastic. Kidney Neoplasms / genetics. Tuberous Sclerosis / complications. Tuberous Sclerosis / genetics. Tumor Suppressor Protein p53 / genetics

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  • (PMID = 18547741.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53
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86. Surabhi VR, Menias C, Prasad SR, Patel AH, Nagar A, Dalrymple NC: Neoplastic and non-neoplastic proliferative disorders of the perirenal space: cross-sectional imaging findings. Radiographics; 2008 Jul-Aug;28(4):1005-17
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  • The perirenal space, located between the anterior and the posterior renal fasciae, is shaped like an inverted cone with an apex that extends into the iliac fossa.
  • Perirenal tumors and pseudotumors primarily originate either from the kidney or as part of a systemic disease process and have characteristic histopathologic features and biologic behavior.
  • The lesions may be classified on the basis of their distribution and imaging features as solitary soft-tissue masses (renal cell carcinoma, lymphangioma, hemangioma, and leiomyoma), rindlike soft-tissue lesions (lymphoma, retroperitoneal fibrosis, and Erdheim-Chester disease), masses containing macroscopic fat (angiomyolipoma, liposarcoma, myelolipoma, and extramedullary hematopoiesis), and multifocal soft-tissue masses (metastases, plasma cell tumors).
  • Because of overlap in imaging findings among these diverse perirenal lesions, a definitive diagnosis in most cases can be established only at histopathologic analysis.
  • However, an imaging pattern-based approach may facilitate the diagnosis and optimal management of perirenal tumors and pseudotumors.
  • [MeSH-major] Connective Tissue Diseases / radiography. Kidney Neoplasms / radiography. Soft Tissue Neoplasms / radiography. Tomography, X-Ray Computed / methods


87. Sooriakumaran P, Gibbs P, Coughlin G, Attard V, Elmslie F, Kingswood C, Taylor J, Corbishley C, Patel U, Anderson C: Angiomyolipomata: challenges, solutions, and future prospects based on over 100 cases treated. BJU Int; 2010 Jan;105(1):101-6
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  • OBJECTIVE: To examine the presentation, management and outcomes of patients with renal angiomyolipoma (AML) over a period of 10 years, at St George's Hospital, London, UK.
  • [MeSH-major] Angiomyolipoma / therapy. Catheter Ablation / methods. Embolization, Therapeutic / methods. Kidney Neoplasms / therapy. Nephrectomy / methods. Tuberous Sclerosis / therapy


88. Fujii T, Zen Y, Sato Y, Sasaki M, Enomae M, Minato H, Masuda S, Uehara T, Katsuyama T, Nakanuma Y: Podoplanin is a useful diagnostic marker for epithelioid hemangioendothelioma of the liver. Mod Pathol; 2008 Feb;21(2):125-30
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  • In this study, we examined podoplanin expression in specimens from 10 normal livers and 73 cases of liver tumors: hemangioma (16 cases), epithelioid hemangioendothelioma (9 cases), angiosarcoma (4 cases), angiomyolipoma (7 cases), hepatocellular carcinoma (11 cases), intrahepatic cholangiocarcinoma (11 cases), and metastatic liver cancer (15 cases).
  • The expression of CD31, CD34, and factor VIII was observed in endothelial cells in all cases of hemangioma, epithelioid hemangioendothelioma, angiosarcoma, and angiomyolipoma with one exception, a case of epithelioid hemangioendothelioma which was without CD31 expression.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Angiomyolipoma / metabolism. Angiomyolipoma / pathology. Bile Duct Neoplasms / metabolism. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / metabolism. Bile Ducts, Intrahepatic / pathology. Carcinoma, Hepatocellular / metabolism. Carcinoma, Hepatocellular / pathology. Cholangiocarcinoma / metabolism. Cholangiocarcinoma / pathology. Diagnosis, Differential. Endothelium, Lymphatic / metabolism. Endothelium, Lymphatic / pathology. Female. Hemangioma / metabolism. Hemangioma / pathology. Hemangiosarcoma / metabolism. Hemangiosarcoma / pathology. Humans. Liver / metabolism. Liver / pathology. Male. Middle Aged

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  • (PMID = 18084256.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Membrane Glycoproteins; 0 / PDPN protein, human
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89. Buĭlov VM, Teodorovich OV, Borisanov AV: [Spiral computed tomography in the differential diagnosis of renal angiomyolipoma with the minimum amount of fatty tissue and renal-cell carcinoma with fatty inclusions]. Vestn Rentgenol Radiol; 2005 Jul-Aug;(4):42-6
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  • [Title] [Spiral computed tomography in the differential diagnosis of renal angiomyolipoma with the minimum amount of fatty tissue and renal-cell carcinoma with fatty inclusions].
  • [MeSH-major] Angiomyolipoma / radiography. Carcinoma, Renal Cell / radiography. Kidney Neoplasms / radiography. Neoplasms, Multiple Primary / radiography. Tomography, Spiral Computed
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Male. Nephrectomy

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  • (PMID = 16353901.001).
  • [ISSN] 0042-4676
  • [Journal-full-title] Vestnik rentgenologii i radiologii
  • [ISO-abbreviation] Vestn Rentgenol Radiol
  • [Language] rus
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Russia (Federation)
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90. Yen YH, Wang JH, Lu SN, Changchien CS: Contrast-enhanced ultrasonography in hepatic angiomyolipoma. J Ultrasound Med; 2005 Jun;24(6):855-9
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  • [Title] Contrast-enhanced ultrasonography in hepatic angiomyolipoma.
  • [MeSH-major] Angiomyolipoma / ultrasonography. Liver Neoplasms / ultrasonography. Ultrasonography, Doppler / methods
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Image Enhancement. Male. Tomography, X-Ray Computed

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  • (PMID = 15914690.001).
  • [ISSN] 0278-4297
  • [Journal-full-title] Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
  • [ISO-abbreviation] J Ultrasound Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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91. Caviezel A, Terraz S, Schmidlin F, Becker C, Iselin CE: Percutaneous cryoablation of small kidney tumours under magnetic resonance imaging guidance: medium-term follow-up. Scand J Urol Nephrol; 2008;42(5):412-6
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  • [Title] Percutaneous cryoablation of small kidney tumours under magnetic resonance imaging guidance: medium-term follow-up.
  • OBJECTIVE: Minimally invasive treatment of small kidney tumours remains a challenge.
  • The goal of this retrospective study was to evaluate the initial clinical experience of magnetic resonance imaging (MRI)-guided percutaneous cryotherapy of small renal tumours.
  • MATERIAL AND METHODS: Seven patients with small renal tumours [mean diameter 21 (11-30) mm] underwent percutaneous renal tumour cryoablation using the Cryo-Hit delivery system.
  • The patients had a solitary kidney (n = 2), renal insufficiency (n = 4) or a kidney graft (n = 1).
  • CONCLUSIONS: In this small group of patients, percutaneous renal tumour cryoablation under MRI guidance was efficient and carried no morbidity.
  • [MeSH-major] Angiomyolipoma / surgery. Carcinoma, Renal Cell / surgery. Cryosurgery / methods. Kidney Neoplasms / surgery. Magnetic Resonance Imaging / methods. Minimally Invasive Surgical Procedures / methods. Postoperative Complications / blood. Surgery, Computer-Assisted / methods

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  • (PMID = 18609277.001).
  • [ISSN] 0036-5599
  • [Journal-full-title] Scandinavian journal of urology and nephrology
  • [ISO-abbreviation] Scand. J. Urol. Nephrol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Sweden
  • [Chemical-registry-number] AYI8EX34EU / Creatinine
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92. Kato S, Seike K, Masue T, Yamamoto N, Maeda S: Epithelioid angiomyolipoma associated with a classic angiomyolipoma. Can J Urol; 2009 Oct;16(5):4857-9
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  • [Title] Epithelioid angiomyolipoma associated with a classic angiomyolipoma.
  • We report a case of renal epithelioid angiomyolipoma that arose in association with a classic angiomyolipoma in a 54-year-old Japanese man without tuberous sclerosis.
  • On the basis of a review of the literature, we suggest that large epithelioid angiomyolipoma may have malignant potential and therefore requires close follow up.
  • [MeSH-major] Angiomyolipoma / diagnosis. Epithelioid Cells / pathology. Kidney Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Follow-Up Studies. Humans. Male. Middle Aged. Nephrectomy. Tomography, X-Ray Computed

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  • (PMID = 19796467.001).
  • [ISSN] 1195-9479
  • [Journal-full-title] The Canadian journal of urology
  • [ISO-abbreviation] Can J Urol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
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93. Xu ZF, Xu HX, Xie XY, Liu GJ, Zheng YL, Lu MD: Renal cell carcinoma and renal angiomyolipoma: differential diagnosis with real-time contrast-enhanced ultrasonography. J Ultrasound Med; 2010 May;29(5):709-17
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  • [Title] Renal cell carcinoma and renal angiomyolipoma: differential diagnosis with real-time contrast-enhanced ultrasonography.
  • OBJECTIVE: The purpose of this study was to evaluate the usefulness of contrast-enhanced ultrasonography (CEUS) in differentiating renal cell carcinoma (RCC) from renal angiomyolipoma (RAML).
  • METHODS: One hundred nineteen patients with 126 renal lesions (33 RAMLs and 93 RCCs) who had undergone CEUS were retrospectively studied.
  • [MeSH-major] Angiomyolipoma / ultrasonography. Carcinoma, Renal Cell / ultrasonography. Kidney Neoplasms / ultrasonography. Phospholipids. Sulfur Hexafluoride. Ultrasonography / methods
  • [MeSH-minor] Adult. Aged. Computer Systems. Contrast Media. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Reproducibility of Results. Sensitivity and Specificity

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  • (PMID = 20427782.001).
  • [ISSN] 1550-9613
  • [Journal-full-title] Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
  • [ISO-abbreviation] J Ultrasound Med
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Phospholipids; 0 / contrast agent BR1; WS7LR3I1D6 / Sulfur Hexafluoride
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94. Radopoulos D, Tahmatzopoulos A, Kalinderis N, Dimitriadis G: Bilateral synchronous occurrence of three different histological types of renal tumor: a case report. J Med Case Rep; 2009;3:6798
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  • [Title] Bilateral synchronous occurrence of three different histological types of renal tumor: a case report.
  • INTRODUCTION: Renal cell carcinomas account for 85% of all renal neoplasms.
  • With the introduction of modern imaging modalities, there has been an increased diagnosis of renal tumors.
  • Recent studies have shown that partial nephrectomy can be as safe as radical nephrectomy for smaller renal tumors.
  • Renal cell carcinomas are usually unilateral, however, they can be bilateral in 2% to 4% of sporadic cases and considerably more common in familial cases.
  • CASE PRESENTATION: In this case report, we describe an unusual case of two bilateral synchronous chromophobe renal cell carcinomas accompanied by an oncocytoma and an angiomyolipoma, that were all treated by open partial nephrectomy.
  • CONCLUSIONS: To the best of our knowledge, this is the first case report on the synchronous occurrence of bilateral chromophobe renal cell carcinomas associated with an oncocytoma and an angiomyolipoma.

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  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
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95. Sibony M, Vieillefond A: [Non clear cell renal cell carcinoma. 2008 update in renal tumor pathology]. Ann Pathol; 2008 Oct;28(5):381-401
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  • [Title] [Non clear cell renal cell carcinoma. 2008 update in renal tumor pathology].
  • Non clear cell renal cell carcinomas represent almost 20% of all renal neoplasms.
  • Since molecular techniques are expensive, diagnosis still relies on morphological and immuno-histochemical criteria detailed hereby.
  • Papillary renal cell carcinomas are the most important group and its classification is more and more complex.
  • It encompasses low-grade papillary carcinomas (type 1 papillary renal cell carcinoma, oncocytic papillary renal cell carcinoma) and high-grade papillary carcinomas (type 2 papillary renal cell carcinoma, juvenile papillary carcinoma corresponding to renal carcinoma associated with Xp11.2 translocations and unclassified carcinomas).
  • The so-called carcinoma of collecting ducts of Bellini and renal medullary carcinoma should be considered as intrarenal urothelial carcinoma or as high-grade papillary or unclassified carcinoma.
  • Sarcomatoid carcinoma derives from morphological progression of any type of renal cell carcinoma.
  • The group of oncocytomas/chromophobe renal cell carcinomas can be considered as a spectrum from benign (oncocytoma) to malignant neoplasm (chromophobe renal cell carcinoma).
  • Angiomyolipoma is usually a benign mesenchymatous neoplasm, that can be sporadic or familial (tuberous sclerosis).
  • In the latter situation, some cases of epithelioid angiomyolipoma (potentially malignant) have been described.
  • Renal epithelial and stromal tumors (REST) is a new concept gathering two benign mixed mesenchymal and epithelial tumors: cystic nephroma and mixed epithelial and stromal tumors (MEST).
  • [MeSH-major] Adenocarcinoma, Clear Cell / pathology. Carcinoma, Renal Cell / pathology. Kidney Neoplasms / pathology
  • [MeSH-minor] Adenoma, Oxyphilic / classification. Adenoma, Oxyphilic / genetics. Adenoma, Oxyphilic / pathology. Carcinoma / classification. Carcinoma / genetics. Carcinoma / pathology. Chromosome Mapping. Chromosomes, Human. Humans. Immunohistochemistry. Kidney / pathology. Kidney Tubules, Collecting / pathology. Necrosis


96. Yamagata Y, Kawauchi S, Tamura H, Murakami A, Sasaki K, Sugino N: A case of HMB45-negative perivascular epithelioid cell tumor (PEComa) of the uterine corpus: a possible diagnostic application of molecular-cytogenetic analysis. Eur J Gynaecol Oncol; 2009;30(2):216-9
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  • We report a case of uterine angiomyolipoma confirmed with molecular-genetic analysis by fluorescence in situ hybridization (FISH).
  • FISH examination revealed chromosome X trisomy, which was comparable to a previously reported molecular-genetic finding of PEComa family tumors including angiomyolipoma.
  • Although the tumor was immunohistochemically negative for HMB-45 antigen, the histological and FISH findings were compatible with angiomyolipoma.
  • [MeSH-major] Antigens, Neoplasm / analysis. Biomarkers, Tumor / analysis. Neoplasm Proteins / analysis. Perivascular Epithelioid Cell Neoplasms / diagnosis. Uterine Neoplasms / diagnosis
  • [MeSH-minor] Adult. Angiomyolipoma / diagnosis. Angiomyolipoma / immunology. Angiomyolipoma / pathology. Chromosomes, Human, X / genetics. Cytogenetic Analysis. Female. Humans. In Situ Hybridization, Fluorescence. Melanoma-Specific Antigens. Trisomy

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  • (PMID = 19480261.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins
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97. Milner J, McNeil B, Alioto J, Proud K, Rubinas T, Picken M, Demos T, Turk T, Perry KT Jr: Fat poor renal angiomyolipoma: patient, computerized tomography and histological findings. J Urol; 2006 Sep;176(3):905-9
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  • [Title] Fat poor renal angiomyolipoma: patient, computerized tomography and histological findings.
  • PURPOSE: We reviewed our experience with fat poor cases of angiomyolipoma.
  • MATERIALS AND METHODS: The records of patients with angiomyolipoma, as determined by pathological study, from 1998 to 2004 were reviewed by recording patient demographics and outcomes.
  • RESULTS: Histologically confirmed angiomyolipoma was found in 15 patients.
  • Of these 15 patients who underwent surgery 11 (73%) had unsuspected angiomyolipoma due to absent fat on computerized tomography and they underwent intervention for presumed renal cell carcinoma.
  • The percent of fat identified per high power field was less than 25% in 12 of 13 fat poor angiomyolipoma lesions (92%) compared to 2 of 4 classic lesions (50%) known to be angiomyolipoma before surgery (p = 0.04).
  • CONCLUSIONS: We suggest that a general definition of fat poor angiomyolipoma should be the failure of imaging to reveal fat within a lesion, thus, making it unsuspected at surgery.
  • These lesions cannot be reliably identified by imaging and they should be managed like all enhancing renal masses.
  • [MeSH-major] Angiolipoma / pathology. Angiolipoma / radiography. Kidney Neoplasms / pathology. Kidney Neoplasms / radiography. Tomography, X-Ray Computed

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  • (PMID = 16890650.001).
  • [ISSN] 0022-5347
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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98. Painuly GP, Goyal S, Nautiyal S: Giant renal angiomyolipoma. BMJ Case Rep; 2009;2009
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  • [Title] Giant renal angiomyolipoma.
  • Ultrasound revealed a large retroperitoneal tumour with fatty elements, arising from the right kidney.
  • Findings of the computed tomography scan were typical for renal angiomyolipoma.

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  • (PMID = 22171231.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3027913
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99. Glasgow CG, Steagall WK, Taveira-Dasilva A, Pacheco-Rodriguez G, Cai X, El-Chemaly S, Moses M, Darling T, Moss J: Lymphangioleiomyomatosis (LAM): molecular insights lead to targeted therapies. Respir Med; 2010 Jul;104 Suppl 1:S45-58
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  • LAM is a rare lung disease, found primarily in women of childbearing age, characterized by cystic lung destruction and abdominal tumors (e.g., renal angiomyolipoma, lymphangioleiomyoma).

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  • [Copyright] Copyright (c) 2010. Published by Elsevier Ltd.
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  • (PMID = 20630348.001).
  • [ISSN] 1532-3064
  • [Journal-full-title] Respiratory medicine
  • [ISO-abbreviation] Respir Med
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z01 HL002541-12; United States / Intramural NIH HHS / / Z01 HL002541-13; United States / Intramural NIH HHS / / ZIA HL002541-14
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p21; 0 / Tumor Suppressor Proteins; 0 / tuberous sclerosis complex 1 protein; 4JG2LF96VF / tuberous sclerosis complex 2 protein; EC 2.7.1.1 / TOR Serine-Threonine Kinases
  • [Other-IDs] NLM/ NIHMS206406; NLM/ PMC3030250
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100. Aguilera Tubet C, Portillo Martín JA, Gutiérrez Baños JL, Ruiz Izquierdo F, Ballestero Diego R, Zubillaga Guerrero S: [Emergency conservative surgery on a unique kidney with broken multiple angiomyolipoma]. Actas Urol Esp; 2007 Feb;31(2):164-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Emergency conservative surgery on a unique kidney with broken multiple angiomyolipoma].
  • [Transliterated title] Cirugía conservadora de urgencia en monorrena por rotura de angiomiolipoma múltiple.
  • A case of retroperitoneal hemorrhage due to the rupture of a multiple angiomyolipoma in a female with a unique kidney is described.
  • [MeSH-major] Angiomyolipoma / complications. Angiomyolipoma / surgery. Emergency Treatment. Kidney / abnormalities. Kidney Neoplasms / complications. Kidney Neoplasms / surgery

  • MedlinePlus Health Information. consumer health - Kidney Cancer.
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  • (PMID = 17645098.001).
  • [ISSN] 0210-4806
  • [Journal-full-title] Actas urologicas españolas
  • [ISO-abbreviation] Actas Urol Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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