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1. Kamimura K, Oosaki A, Sugahara S, Mori S, Moroda T, Satoh O, Morita T, Kimura K, Kamura T, Nomoto M, Aoyagi Y: Malignant potential of hepatic angiomyolipoma: case report and literature review. Clin J Gastroenterol; 2010 Apr;3(2):104-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant potential of hepatic angiomyolipoma: case report and literature review.
  • Hepatic angiomyolipoma (AML) is known as a rare benign tumor with invasive growth.

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  • (PMID = 26190004.001).
  • [ISSN] 1865-7257
  • [Journal-full-title] Clinical journal of gastroenterology
  • [ISO-abbreviation] Clin J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Keywords] NOTNLM ; HMB-45 / Hepatic angiomyolipoma / Malignant / PEComa / Portal vein thrombosis
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2. Abdulkader M, Abercrombie J, McCulloch TA, Kaye PV: Colonic angiomyolipoma with a monotypic expression and a predominant epithelioid component. J Clin Pathol; 2005 Oct;58(10):1107-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Colonic angiomyolipoma with a monotypic expression and a predominant epithelioid component.
  • Angiomyolipomas are rare lesions, often arising in the kidney, and are part of a group of tumours with a diverse appearance and evidence of dual melanocytic and smooth muscle differentiation known as PEComas (tumours of perivascular epithelioid cell origin).
  • [MeSH-major] Angiomyolipoma / ultrastructure. Cecal Neoplasms / ultrastructure

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  • (PMID = 16189161.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1770749
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3. Hao LW, Lin CM, Tsai SH: Spontaneous hemorrhagic angiomyolipoma present with massive hematuria leading to urgent nephrectomy. Am J Emerg Med; 2008 Feb;26(2):249.e3-5
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  • [Title] Spontaneous hemorrhagic angiomyolipoma present with massive hematuria leading to urgent nephrectomy.
  • An immediate surgery is sometimes required for the hemorrhagic uropathy of renal angiomyolipoma.
  • Abdominal and pelvic computed tomographic scans showed a 3 x 5-cm, fat-containing tumor at the left lower pole of the kidney and a bleeding and perirenal hematoma in the left perirenal space.
  • An urgent left nephrectomy was lifesaving for the postoperative finding of renal angiomyolipoma.
  • [MeSH-major] Angiomyolipoma / surgery. Hematuria / etiology. Kidney Neoplasms / surgery. Nephrectomy

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  • (PMID = 18272126.001).
  • [ISSN] 1532-8171
  • [Journal-full-title] The American journal of emergency medicine
  • [ISO-abbreviation] Am J Emerg Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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4. Schwartz BF: Response to the Editorial Comment on Leflore et al. Laparoscopic cryotherapy for pediatric angiomyolipoma: The first report (J Endourol 2007;21:321). J Endourol; 2007 Sep;21(9):1123
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  • [Title] Response to the Editorial Comment on Leflore et al. Laparoscopic cryotherapy for pediatric angiomyolipoma: The first report (J Endourol 2007;21:321).

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  • [CommentOn] J Endourol. 2007 Mar;21(3):321-4; discussion 324 [17444779.001]
  • (PMID = 17941798.001).
  • [ISSN] 0892-7790
  • [Journal-full-title] Journal of endourology
  • [ISO-abbreviation] J. Endourol.
  • [Language] ENG
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cellulose, Oxidized; 0 / FloSeal Matrix; 0 / Hemostatics; 82347-53-3 / Surgicel
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5. Munjal K, Agrawal S, Munjal S: Leiomyomatous angiomyolipoma of kidney. Urol J; 2009;6(2):87
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  • [Title] Leiomyomatous angiomyolipoma of kidney.
  • [MeSH-major] Angiomyolipoma / pathology. Angiomyolipoma / surgery. Kidney Neoplasms / pathology. Kidney Neoplasms / surgery

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  • (PMID = 19472124.001).
  • [ISSN] 1735-546X
  • [Journal-full-title] Urology journal
  • [ISO-abbreviation] Urol J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Iran
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6. Bharwani N, Christmas TJ, Jameson C, Moat N, Sohaib SA: Epithelioid angiomyolipoma: imaging appearances. Br J Radiol; 2009 Dec;82(984):e249-52
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  • [Title] Epithelioid angiomyolipoma: imaging appearances.
  • Epithelioid angiomyolipoma is a recently described rare variant of renal angiomyolipoma.
  • We report the imaging findings from two cases of epithelioid angiomyolipoma: the first in a patient with tuberous sclerosis complex, arising in a horse-shoe kidney and growing into the inferior vena cava and right atrium; the second in a 62-year-old hypertensive man.
  • [MeSH-major] Angiomyolipoma / diagnosis. Kidney Neoplasms / diagnosis
  • [MeSH-minor] Adult. Heart Atria / pathology. Humans. Magnetic Resonance Imaging. Male. Neoplasm Invasiveness. Renal Veins / pathology. Tomography, X-Ray Computed. Tuberous Sclerosis / diagnosis. Tuberous Sclerosis / surgery. Vena Cava, Inferior / pathology

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  • (PMID = 19934066.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3473378
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7. Wolff N, Kabbani W, Bradley T, Raj G, Watumull L, Brugarolas J: Sirolimus and temsirolimus for epithelioid angiomyolipoma. J Clin Oncol; 2010 Feb 10;28(5):e65-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sirolimus and temsirolimus for epithelioid angiomyolipoma.

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  • (PMID = 20048172.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] ENG
  • [Grant] United States / NINDS NIH HHS / NS / K08 NS051843; United States / NINDS NIH HHS / NS / NS051843-05; United States / NINDS NIH HHS / NS / K08 NS051843-05; United States / NINDS NIH HHS / NS / K08NS051843
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 624KN6GM2T / temsirolimus; W36ZG6FT64 / Sirolimus
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8. Wienecke R, Fackler I, Linsenmaier U, Mayer K, Licht T, Kretzler M: Antitumoral activity of rapamycin in renal angiomyolipoma associated with tuberous sclerosis complex. Am J Kidney Dis; 2006 Sep;48(3):e27-9
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  • [Title] Antitumoral activity of rapamycin in renal angiomyolipoma associated with tuberous sclerosis complex.
  • A 19-year old patient with tuberous sclerosis presented with a renal angiomyolipoma.
  • Because animal trials of tuberous sclerosis showed an effect of rapamycin on renal tumors, our patient was administered rapamycin for 6 months.
  • During this time, the renal angiomyolipoma shrank significantly, regrew during an 8-month period, and decreased in size again after readministration of rapamycin.
  • [MeSH-major] Angiomyolipoma / drug therapy. Antibiotics, Antineoplastic / therapeutic use. Kidney Neoplasms / drug therapy. Sirolimus / therapeutic use. Tuberous Sclerosis / complications

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  • (PMID = 16931204.001).
  • [ISSN] 1523-6838
  • [Journal-full-title] American journal of kidney diseases : the official journal of the National Kidney Foundation
  • [ISO-abbreviation] Am. J. Kidney Dis.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; W36ZG6FT64 / Sirolimus
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9. Yoshikawa T, Kawamitsu H, Mitchell DG, Ohno Y, Ku Y, Seo Y, Fujii M, Sugimura K: ADC measurement of abdominal organs and lesions using parallel imaging technique. AJR Am J Roentgenol; 2006 Dec;187(6):1521-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In 200 consecutive clinical patients (122 men and 78 women: mean age, 61.9 years), ADCs were calculated for liver (four segments), spleen, pancreas (head, body, tail), gallbladder, renal parenchyma, and back muscle, and then compared to evaluate the reliability of clinical ADC measurements with parallel imaging.
  • There was no significant difference among ADCs of four liver segments (1.50 +/- 0.24 [SD] x 10(-3) mm2/s - 1.56 +/- 0.31 x 10(-3) mm2/s) and between ADCs of the right and left kidneys (2.65 +/- 0.30 x 10(-3) mm2/s, 2.59 +/- 0.33 x 10(-3) mm2/s).
  • Renal ADCs were significantly lower in patients with renal failure (right: 2.15 +/- 0.30 x 10(-3) mm2/s; left: 2.11 +/- 0.25 x 10(-3) mm2/s) than in those without disease (right: 2.67 +/- 0.29 x 10(-3) mm2/s; left: 2.60 +/- 0.32 x 10(-3) mm2/s) (p < 0.005).
  • ADC of renal angiomyolipoma was significantly lower than those of renal cell carcinoma and healthy renal parenchyma (p < 0.0005).
  • [MeSH-major] Diffusion Magnetic Resonance Imaging / methods. Digestive System / pathology. Gastrointestinal Neoplasms / diagnosis

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  • (PMID = 17114546.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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10. Zhang LH, Sun RC, Chen Y: [A case report of epiglottic angiomyolipoma. ]. Zhonghua Bing Li Xue Za Zhi; 2005 Oct;34(10):645
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  • [Title] [A case report of epiglottic angiomyolipoma. ].
  • [MeSH-major] Angiomyolipoma / pathology. Epiglottis. Laryngeal Neoplasms / pathology

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  • (PMID = 17526131.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Actins; 0 / smooth muscle actin, rat; 9001-27-8 / Factor VIII
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11. Kazantseva IA, Pavlova TV, Iankovoĭ AG: [Angiomyolipoma of the secondary contracted kidney in a renal graft recipient]. Arkh Patol; 2008 Jan-Feb;70(1):45-6
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  • [Title] [Angiomyolipoma of the secondary contracted kidney in a renal graft recipient].
  • The special feature of the presented case is a combination of various pathological processes which developed in the recipient's kidney after renal transplantation, such as chronic glomerulonephritis progressing to nephrosclerosis; benign tumor to angiomyolipoma, xantogranulomatosis, and thesaurismosis which develop after massive infusion therapy.
  • [MeSH-major] Angiomyolipoma / pathology. Kidney Neoplasms / pathology. Kidney Transplantation. Postoperative Complications / pathology

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  • (PMID = 18368809.001).
  • [ISSN] 0004-1955
  • [Journal-full-title] Arkhiv patologii
  • [ISO-abbreviation] Arkh. Patol.
  • [Language] rus
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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12. Marsilia GM, Boscaino A, La Mura A, Ceriello A, De Ritis R: Hepatic angiomyolipoma and intramural small intestinal schwannoma: a coincidence or a relationship? Int J Surg Pathol; 2010 Dec;18(6):537-9
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  • [Title] Hepatic angiomyolipoma and intramural small intestinal schwannoma: a coincidence or a relationship?
  • We report a case of hepatic angiomyolipoma associated to a small bowel schwannoma in a 40-years old woman.
  • Histologically, hepatic angiomyolipoma showed oncocytic features and scanty adipose tissue, the tumor cells expressed desmin, smooth muscle actin, S-100 protein and HMB45.
  • To the best of our knowledge, no case of hepatic angiomyolipoma has been previously reported in association with intestinal schwannoma.
  • [MeSH-major] Angiomyolipoma / pathology. Jejunal Neoplasms / pathology. Liver Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Neurilemmoma / pathology

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  • (PMID = 19282295.001).
  • [ISSN] 1940-2465
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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13. Woodward PJ, Sohaey R, Kennedy A, Koeller KK: From the archives of the AFIP: a comprehensive review of fetal tumors with pathologic correlation. Radiographics; 2005 Jan-Feb;25(1):215-42
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  • Other fetal neoplasms include soft-tissue tumors (both benign and malignant), leukemia, mesenchymal hamartoma of the kidney, and liver tumors (hemangioendothelioma, mesenchymal hamartoma, and hepatoblastoma).
  • [MeSH-major] Fetal Diseases / diagnosis. Neoplasms / diagnosis
  • [MeSH-minor] Brain Neoplasms / diagnosis. Female. Humans. Magnetic Resonance Imaging. Pregnancy. Teratoma / diagnosis. Ultrasonography, Prenatal

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  • (PMID = 15653597.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 82
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14. Hornick JL, Fletcher CD: Sclerosing PEComa: clinicopathologic analysis of a distinctive variant with a predilection for the retroperitoneum. Am J Surg Pathol; 2008 Apr;32(4):493-501
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  • PEComas (tumors showing perivascular epithelioid cell differentiation) are a family of mesenchymal neoplasms that include angiomyolipoma, clear cell "sugar" tumor of the lung, lymphangiomyomatosis, and a group of uncommon lesions that arise in soft tissue, visceral organs, and skin.

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  • (PMID = 18223480.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, Neoplasm; 0 / Calmodulin-Binding Proteins; 0 / Desmin; 0 / MART-1 Antigen; 0 / MITF protein, human; 0 / MLANA protein, human; 0 / Melanoma-Specific Antigens; 0 / Microphthalmia-Associated Transcription Factor; 0 / Mucin-1; 0 / Neoplasm Proteins; 0 / S100 Proteins; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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15. Umeoka S, Koyama T, Miki Y, Akai M, Tsutsui K, Togashi K: Pictorial review of tuberous sclerosis in various organs. Radiographics; 2008 Nov-Dec;28(7):e32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The diagnosis is usually established on the basis of diagnostic criteria applied to physical or radiologic findings.
  • Because the classical triad of epilepsy, mental retardation, and adenoma sebaceum is uncommonly seen at clinical examination, radiologic examinations can play an important role in the diagnosis of tuberous sclerosis and in treatment.
  • Cardiac rhabdomyoma, renal angiomyolipoma, and neurologic involvement encompassing cortical or subependymal tubers and white matter abnormalities are the common radiologic findings.
  • The presence of pulmonary lymphangioleiomyomatosis, multifocal micronodular pneumocyte hyperplasia, or multiple renal cysts also raises suspicion of tuberous sclerosis.
  • Familiarity with the clinical and radiologic findings in various organs is crucial in diagnosis and treatment.
  • [MeSH-major] Multiple Organ Failure / diagnosis. Tomography, X-Ray Computed / methods. Tuberous Sclerosis / diagnosis

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  • (PMID = 18772274.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 60
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16. Lesma E, Sirchia SM, Ancona S, Carelli S, Bosari S, Ghelma F, Montanari E, Di Giulio AM, Gorio A: The methylation of the TSC2 promoter underlies the abnormal growth of TSC2 angiomyolipoma-derived smooth muscle cells. Am J Pathol; 2009 Jun;174(6):2150-9
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  • [Title] The methylation of the TSC2 promoter underlies the abnormal growth of TSC2 angiomyolipoma-derived smooth muscle cells.
  • Smooth muscle-like cells (ASMs) were isolated from an angiomyolipoma of a patient with TSC.
  • [MeSH-major] Angiomyolipoma / genetics. Angiomyolipoma / pathology. DNA Methylation / genetics. Myocytes, Smooth Muscle / pathology. Tumor Suppressor Proteins / genetics
  • [MeSH-minor] Adult. Antibiotics, Antineoplastic / pharmacology. Antigens, Neoplasm. Apoptosis / drug effects. Blotting, Western. Cell Proliferation / drug effects. DNA Mutational Analysis. Germ-Line Mutation. Humans. Immunohistochemistry. In Situ Nick-End Labeling. Kidney Neoplasms / genetics. Kidney Neoplasms / metabolism. Kidney Neoplasms / pathology. Male. Melanoma-Specific Antigens. Microscopy, Fluorescence. Neoplasm Proteins. Promoter Regions, Genetic / genetics. Sirolimus / pharmacology. Tuberous Sclerosis / complications. Tuberous Sclerosis / genetics. Tuberous Sclerosis / pathology

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  • (PMID = 19443708.001).
  • [ISSN] 1525-2191
  • [Journal-full-title] The American journal of pathology
  • [ISO-abbreviation] Am. J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Antigens, Neoplasm; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins; 0 / Tumor Suppressor Proteins; 4JG2LF96VF / tuberous sclerosis complex 2 protein; W36ZG6FT64 / Sirolimus
  • [Other-IDs] NLM/ PMC2684180
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17. Katsanos K, Sabharwal T, Ahmad F, Dourado R, Adam A: Onyx embolization of sporadic angiomyolipoma. Cardiovasc Intervent Radiol; 2009 Nov;32(6):1291-5
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  • [Title] Onyx embolization of sporadic angiomyolipoma.
  • Percutaneous embolization is the currently preferred treatment of symptomatic or ruptured renal angiomyolipomas (AMLs).
  • [MeSH-major] Angiomyolipoma / therapy. Dimethyl Sulfoxide / therapeutic use. Kidney Neoplasms / therapy. Polyvinyls / therapeutic use

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  • (PMID = 19083054.001).
  • [ISSN] 1432-086X
  • [Journal-full-title] Cardiovascular and interventional radiology
  • [ISO-abbreviation] Cardiovasc Intervent Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Onyx copolymer; 0 / Polyvinyls; YOW8V9698H / Dimethyl Sulfoxide
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18. Kannangai R, Diehl AM, Sicklick J, Rojkind M, Thomas D, Torbenson M: Hepatic angiomyolipoma and hepatic stellate cells share a similar gene expression profile. Hum Pathol; 2005 Apr;36(4):341-7
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  • [Title] Hepatic angiomyolipoma and hepatic stellate cells share a similar gene expression profile.
  • [MeSH-major] Angiomyolipoma / metabolism. Hepatocytes / metabolism

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  • (PMID = 15891994.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Grant] United States / NIAAA NIH HHS / AA / AA010154; United States / NIAAA NIH HHS / AA / AA10541; United States / NIDA NIH HHS / DA / DA016078; United States / NIDA NIH HHS / DA / DA016370; United States / NIDDK NIH HHS / DK / DK53792
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins
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19. Surabhi VR, Menias C, Prasad SR, Patel AH, Nagar A, Dalrymple NC: Neoplastic and non-neoplastic proliferative disorders of the perirenal space: cross-sectional imaging findings. Radiographics; 2008 Jul-Aug;28(4):1005-17
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  • The perirenal space, located between the anterior and the posterior renal fasciae, is shaped like an inverted cone with an apex that extends into the iliac fossa.
  • Perirenal tumors and pseudotumors primarily originate either from the kidney or as part of a systemic disease process and have characteristic histopathologic features and biologic behavior.
  • The lesions may be classified on the basis of their distribution and imaging features as solitary soft-tissue masses (renal cell carcinoma, lymphangioma, hemangioma, and leiomyoma), rindlike soft-tissue lesions (lymphoma, retroperitoneal fibrosis, and Erdheim-Chester disease), masses containing macroscopic fat (angiomyolipoma, liposarcoma, myelolipoma, and extramedullary hematopoiesis), and multifocal soft-tissue masses (metastases, plasma cell tumors).
  • Because of overlap in imaging findings among these diverse perirenal lesions, a definitive diagnosis in most cases can be established only at histopathologic analysis.
  • However, an imaging pattern-based approach may facilitate the diagnosis and optimal management of perirenal tumors and pseudotumors.
  • [MeSH-major] Connective Tissue Diseases / radiography. Kidney Neoplasms / radiography. Soft Tissue Neoplasms / radiography. Tomography, X-Ray Computed / methods


20. Patil AR, Chandra R, Gupta A, Thukral BB: Giant aneurysm formation in sporadic renal angiomyolipoma. J Radiol Case Rep; 2010;4(6):21-7
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  • [Title] Giant aneurysm formation in sporadic renal angiomyolipoma.
  • Angiomyolipomas are the most common mesenchymal renal neoplasms.
  • Two types have been described: (i) sporadic angiomyolipoma and (ii) angiomyolipoma associated with tuberous sclerosis.
  • We report a rare case of aneurysm formation in a sporadic angiomyolipoma.

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  • (PMID = 22470737.001).
  • [ISSN] 1943-0922
  • [Journal-full-title] Journal of radiology case reports
  • [ISO-abbreviation] J Radiol Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3303414
  • [Keywords] NOTNLM ; Aneurysm / Angiomyolipoma / Computed Tomography / Tuberous Sclerosis complex
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21. Jiang X, Kenerson H, Aicher L, Miyaoka R, Eary J, Bissler J, Yeung RS: The tuberous sclerosis complex regulates trafficking of glucose transporters and glucose uptake. Am J Pathol; 2008 Jun;172(6):1748-56
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  • We tested this hypothesis in eight renal angiomyolipomas in which the loss of tuberous sclerosis complex (TSC) 1/2 function gave rise to constitutive mTORC1 activation.

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  • (PMID = 18511518.001).
  • [ISSN] 1525-2191
  • [Journal-full-title] The American journal of pathology
  • [ISO-abbreviation] Am. J. Pathol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA077882; United States / NCI NIH HHS / CA / R01 CA102662; United States / NCI NIH HHS / CA / CA077882; United States / NCI NIH HHS / CA / CA102662
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Crtc1 protein, rat; 0 / Glucose Transport Proteins, Facilitative; 0 / Glucose Transporter Type 1; 0 / Glucose Transporter Type 2; 0 / Glucose Transporter Type 4; 0 / Multiprotein Complexes; 0 / Proteins; 0 / Radiopharmaceuticals; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins; 0 / mechanistic target of rapamycin complex 1; 0 / tuberous sclerosis complex 1 protein; 0Z5B2CJX4D / Fluorodeoxyglucose F18; 4JG2LF96VF / tuberous sclerosis complex 2 protein; EC 2.7.1.1 / TOR Serine-Threonine Kinases; IY9XDZ35W2 / Glucose
  • [Other-IDs] NLM/ PMC2408433
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22. Williams TR, Oakes MF: Metastatic breast carcinoma to renal angiomyolipomas in tuberous sclerosis. Urology; 2008 Feb;71(2):352.e5-7
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  • [Title] Metastatic breast carcinoma to renal angiomyolipomas in tuberous sclerosis.
  • Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disease manifesting as hamartomatous involvement of several organs, including brain, kidneys, skin, heart, lungs, and retina.
  • We report the first case of a patient with TSC, with large bilateral renal angiomyolipomas (AML), who developed multiple soft tissue masses within her primarily fatty AMLs, resulting from metastatic breast cancer.
  • [MeSH-major] Angiomyolipoma / complications. Angiomyolipoma / pathology. Breast Neoplasms / complications. Breast Neoplasms / pathology. Kidney Neoplasms / complications. Kidney Neoplasms / secondary. Tuberous Sclerosis / complications


23. Schillinger F, Montagnac R: [Renal lesions in tuberous sclerosis]. Nephrol Ther; 2006 Jan;2 Suppl 2:S123-6
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  • [Title] [Renal lesions in tuberous sclerosis].
  • Renal tumours, in tuberous sclerosis, are mainly benign and correspond to angiomyolipomas, multiple and bilateral, sometimes enormous with an hemorrhagic risk, frequently associated with cysts of variable size and number and seldom with high metastatic carcinomas.
  • Chronic renal failure is rare and related to focal glomerulosclerosis secondary to hyperfiltration due to nephronic reduction owing to surgery or to tumour invasion, in particular cysts.
  • Data about 65 patients with tuberous sclerosis and chronic renal failure were collected thanks to a national survey.
  • They were females in 63.1% of cases, with a mean age of 29, 2 years at the time of the diagnosis of tuberous sclerosis, revealed in near half of cases by renal involvement.
  • All but one of the 48 patients with end stage renal failure were treated by dialysis; 20 were transplanted, with good results.
  • [MeSH-major] Kidney / pathology. Kidney Neoplasms / epidemiology. Tuberous Sclerosis / pathology
  • [MeSH-minor] Angiomyolipoma / diagnosis. Angiomyolipoma / epidemiology. Angiomyolipoma / pathology. Glomerulosclerosis, Focal Segmental / etiology. Humans. Kidney Failure, Chronic / complications. Neoplasm Invasiveness


24. McKinney CA, Geiger JD, Castle VP, Ruiz RE, Strouse PJ: Aggressive hepatic angiomyolipoma in a child. Pediatr Hematol Oncol; 2005 Jan-Feb;22(1):17-24
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  • [Title] Aggressive hepatic angiomyolipoma in a child.
  • Angiomyolipoma is a tumor of the kidney and, more rarely, the liver, which histologically consists of smooth muscle cells, adipose cells, and abnormal blood vessels in varying proportions.
  • This tumor is generally benign and resection is curative, but here the authors present the case of a 14-year-old girl with an unusual primary hepatic angiomyolipoma that recurred following resection and behaved aggressively.
  • [MeSH-major] Angiomyolipoma / pathology. Liver Neoplasms / pathology

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  • (PMID = 15770828.001).
  • [ISSN] 0888-0018
  • [Journal-full-title] Pediatric hematology and oncology
  • [ISO-abbreviation] Pediatr Hematol Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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25. Shimada S, Harada H, Ishizawa K, Hirose T: Retroperitoneal lipomatous angiomyolipoma associated with amyloid deposition masquerading as well-differentiated liposarcoma. Pathol Int; 2006 Oct;56(10):638-41
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  • [Title] Retroperitoneal lipomatous angiomyolipoma associated with amyloid deposition masquerading as well-differentiated liposarcoma.
  • Reported herein is a case of retroperitoneal angiomyolipoma associated with amyloid deposition, masquerading as well-differentiated liposarcoma.
  • Therefore, the tumor was diagnosed as lipomatous angiomyolipoma.
  • After the diagnosis, it was found that the patient had multiple myeloma and cardiac amyloidosis, suggesting that the amyloid deposition within the tumor was a complication of the myeloma.
  • Lipomatous angiomyolipoma may be a diagnostic pitfall of retroperitoneal lipomatous tumors.
  • [MeSH-major] Amyloid / metabolism. Angiomyolipoma / diagnosis. Angiomyolipoma / metabolism. Liposarcoma / diagnosis. Liposarcoma / metabolism. Retroperitoneal Neoplasms / diagnosis. Retroperitoneal Neoplasms / metabolism
  • [MeSH-minor] Aged. Cyclin-Dependent Kinase 4 / genetics. Cyclin-Dependent Kinase 4 / metabolism. Diagnosis, Differential. Female. Gene Expression Regulation, Enzymologic. Gene Expression Regulation, Neoplastic. Humans. Proto-Oncogene Proteins c-mdm2 / genetics. Proto-Oncogene Proteins c-mdm2 / metabolism

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  • (PMID = 16984623.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Amyloid; EC 2.7.11.22 / Cyclin-Dependent Kinase 4; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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26. Prasad SR, Surabhi VR, Menias CO, Raut AA, Chintapalli KN: Benign renal neoplasms in adults: cross-sectional imaging findings. AJR Am J Roentgenol; 2008 Jan;190(1):158-64
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  • [Title] Benign renal neoplasms in adults: cross-sectional imaging findings.
  • OBJECTIVE: A broad spectrum of benign renal neoplasms in adults shows characteristic ontogeny, histology, and tumor biology.
  • Benign renal tumors are classified into renal cell tumors, metanephric tumors, mesenchymal tumors, and mixed epithelial and mesenchymal tumors.
  • However, because of overlapping of findings between benign and malignant renal tumors, histologic evaluation may be required to establish a definitive diagnosis.
  • CONCLUSION: We attempt to provide a comprehensive, contemporary review of benign renal neoplasms that occur in adults, focusing on cross-sectional imaging characteristics.
  • [MeSH-major] Kidney Neoplasms / diagnosis
  • [MeSH-minor] Adenofibroma / diagnosis. Adenoma / diagnosis. Adenoma, Oxyphilic / diagnosis. Adult. Aged. Angiomyolipoma / diagnosis. Carcinoma, Renal Cell / diagnosis. Cross-Sectional Studies. Diagnosis, Differential. Female. Hemangioma / diagnosis. Humans. Leiomyoma / diagnosis. Magnetic Resonance Imaging. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 18094306.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 62
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27. Vallmanya F, Placer J, Pou Serradell A, Cortadellas R, Gelabert-Mas A: Tuberous sclerosis complex. Forty-years of follow-up of a patient affected. Arch Esp Urol; 2006 Jan-Feb;59(1):105-7
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  • OBJECTIVES: To report the case of a patient diagnosed with tuberous sclerosis complex (TSC), describe its clinical features, diagnosis, and to attract attention on the fact that after 40 years of follow-up, the patient has presented practically all the manifestations described in the literature.
  • Abdominal CT scan showed a 20 cm diameter heterogeneous mass in the left kidney suggesting hemorrhage of an angiomyolipoma.
  • RESULTS: Left radical nephrectomy was performed and the pathological study of the surgical specimen confirmed the diagnosis of angiomyolipoma.
  • CT scan is usually enough for the diagnosis of angiomyolipomas.
  • Complete nephrectomy is appropriate when the whole kidney has been replaced by angiomyolipoma.
  • The identification of molecular markers (HMB-45) facilitates histopathological diagnosis.
  • [MeSH-major] Tuberous Sclerosis / diagnosis

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  • (PMID = 16568704.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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28. Magro G, Lanzafame S: Sporadic subcutaneous angiomyolipoma with expression of estrogen and progesterone receptors. Virchows Arch; 2007 Jan;450(1):123-5
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  • [Title] Sporadic subcutaneous angiomyolipoma with expression of estrogen and progesterone receptors.
  • [MeSH-major] Angiomyolipoma / pathology. Receptors, Estrogen / analysis. Receptors, Progesterone / analysis. Skin Neoplasms / pathology

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  • [Cites] Chest. 2000 Jan;117(1):25-30 [10631194.001]
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  • (PMID = 17124601.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Receptors, Estrogen; 0 / Receptors, Progesterone
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29. Wright T, Sooriakumaran P: Renal angiomyolipoma presenting with massive retroperitoneal haemorrhage due to deranged clotting factors: a case report. Cases J; 2008;1(1):213
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  • [Title] Renal angiomyolipoma presenting with massive retroperitoneal haemorrhage due to deranged clotting factors: a case report.
  • BACKGROUND: Angiomyolipomata of the kidney are unusual lesions composed of abnormal vasculature, smooth muscle, and adipose elements.
  • The underlying diagnosis of renal angiomyolipoma was diagnosed based on CT findings.
  • Emergency resuscitation and selective interpolar arterial embolization was performed which saved the patient's life as well as his kidney.
  • CONCLUSION: This case illustrates the clinical scenario of massive retroperitoneal haemorrhage in an anticoagulated patient with renal angiomyolipomata.
  • In the emergent situation, adequate resuscitation along ABC principles, as well as control of haemorrhage with either nephrectomy (partial or radical), non-selective renal arterial embolization, or selective embolization of the feeding vessel(s), is necessary.
  • For this to occur, it is imperative to consider the diagnosis early in warfarinized patients (and others at risk of bleeding) who present with abdominal pain.
  • The authors hope this case report highlights to readers the clinical scenario of massive retroperitoneal haemorrhage in anticoagulated patients with renal angiomyolipomata so that they can deal appropriately with such presentations.

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  • [Cites] Clin Nephrol. 1998 May;49(5):281-6 [9617489.001]
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  • (PMID = 18834543.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2567302
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30. Verhoest G, Manunta A, Bensalah K, Vincendeau S, Rioux-Leclercq N, Guillé F, Patard JJ: Laparoscopic partial nephrectomy with clamping of the renal parenchyma: initial experience. Eur Urol; 2007 Nov;52(5):1340-6
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  • [Title] Laparoscopic partial nephrectomy with clamping of the renal parenchyma: initial experience.
  • OBJECTIVES: Partial nephrectomy by laparoscopy offers patients conservative surgery and a mini-invasive approach; however, clamping of the renal pedicle and the induced warm ischaemia can damage the renal parenchyma.
  • We present a technique of laparoscopic partial nephrectomy with haemostasis obtained by clamping of the renal parenchyma.
  • After a working space is created by pneumodissection, Gerota's fascia is incised and the kidney convexity is dissected.
  • The renal parenchyma is clamped and the tumour is excised in a bloodless field.
  • The cut renal parenchyma is coated with biologic glue.
  • Final pathologic examination revealed clear cell carcinoma in three cases and angiomyolipoma and oncocytoma in one case each.
  • CONCLUSION: Laparoscopic partial nephrectomy with clamping of the renal parenchyma can be performed in selected patients with peripherally placed tumours.
  • [MeSH-major] Carcinoma, Renal Cell / surgery. Hemostasis, Endoscopic / methods. Kidney Neoplasms / surgery. Laparoscopy / methods. Nephrectomy / methods. Reperfusion Injury / prevention & control

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  • [CommentIn] Eur Urol. 2007 Nov;52(5):1303-5 [17566640.001]
  • (PMID = 17498865.001).
  • [ISSN] 0302-2838
  • [Journal-full-title] European urology
  • [ISO-abbreviation] Eur. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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31. Mai KT, Elkeilani A, Veinot JP: Mixed epithelial and stromal tumour (MEST) of the kidney: report of 14 cases with male and PEComatous variants and proposed histopathogenesis. Pathology; 2007 Apr;39(2):235-40
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  • [Title] Mixed epithelial and stromal tumour (MEST) of the kidney: report of 14 cases with male and PEComatous variants and proposed histopathogenesis.
  • METHODS AND RESULTS: Fourteen MEST were originally diagnosed as cystic nephroma which represents an incidence of 1.6% of renal neoplasms in adults.
  • The epithelial component displayed features of müllerian epithelium and reactive renal tubular cells.
  • In two male cases, MEST consisted of fibrous and smooth muscle stroma and cysts lined only by reactive renal tubular cells.
  • CONCLUSIONS: MEST represents a tumour developing from müllerian-like stromal cells in the kidney.
  • The neoplastic stroma encroaches on the renal tubules and has the potential to stimulate the growth of the renal tubules by contact, with development into cysts.
  • Furthermore, the müllerian stroma likely induces the renal tubules to differentiate into müllerian-like epithelium.
  • [MeSH-major] Kidney Neoplasms / pathology. Neoplasms, Complex and Mixed / pathology
  • [MeSH-minor] Adult. Aged. Angiomyolipoma / pathology. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Kidney Diseases, Cystic / pathology. Male. Middle Aged. Receptors, Estrogen / metabolism. Receptors, Progesterone / metabolism. Sex Factors

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  • (PMID = 17454754.001).
  • [ISSN] 0031-3025
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Receptors, Estrogen; 0 / Receptors, Progesterone
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32. Mahimainathan L, Ghosh-Choudhury N, Venkatesan B, Das F, Mandal CC, Dey N, Habib SL, Kasinath BS, Abboud HE, Ghosh Choudhury G: TSC2 deficiency increases PTEN via HIF1alpha. J Biol Chem; 2009 Oct 9;284(41):27790-8
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  • Finally, we demonstrate a positive correlation between expression of HIF1alpha and PTEN in renal angiomyolipomas from TSC patients.

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  • (PMID = 19648120.001).
  • [ISSN] 1083-351X
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / R01 DK50190; United States / NIAMS NIH HHS / AR / R01 AR52425; United States / NIDDK NIH HHS / DK / R29 DK050190; United States / NIDDK NIH HHS / DK / R01 DK078971; United States / NIDDK NIH HHS / DK / R01 DK050190
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / HIF1A protein, human; 0 / Hif1a protein, mouse; 0 / Hypoxia-Inducible Factor 1, alpha Subunit; 0 / RNA, Small Interfering; 0 / Tumor Suppressor Proteins; 4JG2LF96VF / tuberous sclerosis complex 2 protein; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 3.1.3.48 / PTEN protein, human; EC 3.1.3.48 / Pten protein, mouse; EC 3.1.3.67 / PTEN Phosphohydrolase
  • [Other-IDs] NLM/ PMC2788829
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33. Jiménez Heffernan JA, González-Peramato P, Vicandi B, López Ferrer P, Serrano A, Pérez Campos A, Viguer JM: [Usefulness of cytology in diagnosis and management of renal and perirenal tumors in adults]. Actas Urol Esp; 2007 Oct;31(9):957-65
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  • [Title] [Usefulness of cytology in diagnosis and management of renal and perirenal tumors in adults].
  • INTRODUCTION: The use more and more extended of tumorectomy, partial nephrectomy and nonsurgical treatments of renal tumors has supposed a renewed interest in the diagnosis use of cytology.
  • Whether during preoperative period, through the puncture aspiration with fine needle (PAAF), or during the intraoperative analysis, the cytology offers the possibility of a specific morphologic diagnosis.
  • In this revision the information concerning the diagnostic value of the cytology in renal tumors is updated.
  • MATERIAL AND METHODS: The references related to renal masses cytological descriptions has been reviewed.
  • RESULTS: Between neoplasias with more cytological typical presentation are the clear cell renal and papillary carcinomas.
  • For the diagnosis of angiomyolipoma, urothelial carcinoma and kidney metastasis, the clinical and image information are of great interest for the pathologist.
  • The integration of these data usually allows a specific diagnosis.
  • CONCLUSION: Generally, cytology reflects with accuracy the histological characteristics of renal neoplasias, allowing in many cases a specific diagnosis.
  • [MeSH-major] Carcinoma, Renal Cell / pathology. Kidney Neoplasms / pathology

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  • (PMID = 18257365.001).
  • [ISSN] 0210-4806
  • [Journal-full-title] Actas urologicas españolas
  • [ISO-abbreviation] Actas Urol Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 52
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34. Culty T, Molinie V, Lebret T, Savareux L, Souid M, Delahousse M, Botto H: TSC2/PKD1 contiguous gene syndrome in an adult. Minerva Urol Nefrol; 2006 Dec;58(4):351-4
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  • A 48-year-old woman with a history of autosomal-dominant polycystic kidney disease (ADPKD), was found to have multiple renal angiomyolipomas on a pathological examination after nephrectomy.
  • The clinical and pathological presentation is consistent with the diagnosis of TSC2/PKD1 contiguous gene syndrome, caused by the simultaneous loss of TSC2 and PKD1, the two major genes for tuberous sclerosis complex and ADPKD.
  • [MeSH-major] Angiomyolipoma / genetics. Polycystic Kidney, Autosomal Dominant / genetics. TRPP Cation Channels. Tuberous Sclerosis / genetics. Tumor Suppressor Proteins / genetics

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  • (PMID = 17268401.001).
  • [ISSN] 0393-2249
  • [Journal-full-title] Minerva urologica e nefrologica = The Italian journal of urology and nephrology
  • [ISO-abbreviation] Minerva Urol Nefrol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / TRPP Cation Channels; 0 / Tumor Suppressor Proteins; 0 / polycystic kidney disease 1 protein; 4JG2LF96VF / tuberous sclerosis complex 2 protein
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35. Li T, Fan J, Qin LX, Zhou J, Sun HC, Wang L, Ye QH, Qiu SJ, Tang ZY: [A clinicopathologic study of hepatic angiomyolipoma]. Zhonghua Wai Ke Za Zhi; 2009 Oct 15;47(20):1536-9
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  • [Title] [A clinicopathologic study of hepatic angiomyolipoma].
  • OBJECTIVE: To investigate the clinicopathologic features, diagnosis and treatment of hepatic angiomyolipoma (HAML).
  • Definitive diagnosis of HAML depends on the pathohistological findings and HMB-45 positive myoid cell is an important diagnostic marker.
  • [MeSH-major] Angiomyolipoma / pathology. Liver Neoplasms / pathology

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  • (PMID = 20092740.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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36. Lipsky M, Richardson I, Tareen B: A case of pararenal angiomyolipoma arising from an existing exophytic angiomyolipoma. Can Urol Assoc J; 2010 Jun;4(3):E79-81
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  • [Title] A case of pararenal angiomyolipoma arising from an existing exophytic angiomyolipoma.
  • A 52-year-old healthy woman with a congenital solitary right kidney presented with an incidentally found pararenal mass.
  • Computed tomography and magnetic resonance imaging revealed an exophytic mass in the right kidney consistent with an angiomyolipoma and an additional enhancing pararenal mass that contained fatty elements.
  • Differential diagnosis of the mass included liposarcoma and angiomyolipoma.
  • Upon exploration, the exophytic angiomyolipoma was found to be contiguous with the pararenal mass via an isthmus of fatty tissue.
  • Frozen sections were taken from both masses which confirmed that both were angiomyolipoma.
  • This is the first case reported in the literature wherein an angiomyolipoma extended extrarenally and formed a significantly larger pararenal mass.

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  • [Publication-type] Journal Article
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37. Takahara M, Miyake Y, Matsumoto K, Kawai D, Kaji E, Toyokawa T, Nakatsu M, Ando M, Hirohata M: A case of hepatic angiomyolipoma difficult to distinguish from hepatocellular carcinoma. World J Gastroenterol; 2009 Jun 21;15(23):2930-2
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  • [Title] A case of hepatic angiomyolipoma difficult to distinguish from hepatocellular carcinoma.
  • We report a case of hepatic angiomyolipoma with uncommon clinical features.
  • In cases with uncommon features of angiomyolipoma, it is quite difficult to distinguish angiomyolipoma from hepatocellular carcinoma.
  • [MeSH-major] Angiomyolipoma. Carcinoma, Hepatocellular. Liver Neoplasms

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  • [Cites] Abdom Imaging. 2002 Mar-Apr;27(2):180-3 [11847577.001]
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  • (PMID = 19533821.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC2699017
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38. De Padua M, Gupta N, Broor SL, Govil D: Duodenal angiomyolipoma: a case report. Indian J Pathol Microbiol; 2007 Jul;50(3):568-9
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  • [Title] Duodenal angiomyolipoma: a case report.
  • The authors present a case of duodenal angiomyolipoma.
  • Angiomyolipoma is a benign neoplasm, the most common site being the kidney.
  • Only one case of duodenal angiomyolipoma has been reported.
  • Endoscopy revealed a duodenal polyp which on histopathology revealed features of angiomyolipoma.
  • Surgical excision of angiomyolipoma is usually curative with rare cases of local recurrence.
  • [MeSH-major] Angiomyolipoma / diagnosis. Duodenum / pathology. Intestinal Neoplasms / diagnosis

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  • [CommentIn] Indian J Pathol Microbiol. 2010 Oct-Dec;53(4):859 [21045449.001]
  • (PMID = 17883138.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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39. Yang Y, Song Y, Hong BF: [The use of balloon catheter in surgical treatment of renal angiomyolipoma with a caval thrombus: 1 case report and literature review]. Zhonghua Wai Ke Za Zhi; 2007 Jun 15;45(12):836-8
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  • [Title] [The use of balloon catheter in surgical treatment of renal angiomyolipoma with a caval thrombus: 1 case report and literature review].
  • OBJECTIVE: To present one cases of the use of balloon catheter in surgical treatment of renal angiomyolipoma involving the renal vein and vena cava as a tumor thrombus and review literatures.
  • METHODS: Abdominal ultrasound and CT and MRI demonstrated a large right renal mass with tumor thrombus in the inferior vena cava.
  • RESULTS: The pathological diagnosis was angiomyolipoma.
  • CONCLUSION: Renal angiomyolipoma with a tumor thrombus should be paid more attention.
  • [MeSH-major] Angiomyolipoma / surgery. Balloon Occlusion. Embolectomy / methods. Embolism / surgery. Kidney Neoplasms / surgery

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  • (PMID = 17845787.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 10
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40. Coulibaly B, Bouvier C, Payan MJ, Thomas P: Recurrent dedifferentiated liposarcoma of mediastinum involving lung and pleura. Interact Cardiovasc Thorac Surg; 2009 Oct;9(4):741-2
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  • A woman who complained of dyspnea showed on imaging features a bulky posterior mediastinal mass which was completely excised and initially misdiagnosed as an angiomyolipoma.

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  • (PMID = 19589790.001).
  • [ISSN] 1569-9285
  • [Journal-full-title] Interactive cardiovascular and thoracic surgery
  • [ISO-abbreviation] Interact Cardiovasc Thorac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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41. Park BK: Comments on "Distribution of renal tumor growth rates determined by using serial volumetric CT measurements". Radiology; 2009 Jul;252(1):314; author reply 314-5
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  • [Title] Comments on "Distribution of renal tumor growth rates determined by using serial volumetric CT measurements".
  • [MeSH-major] Cone-Beam Computed Tomography / methods. Kidney Cortex / radiography. Kidney Neoplasms / radiography
  • [MeSH-minor] Adenoma, Oxyphilic / pathology. Adenoma, Oxyphilic / radiography. Adenoma, Oxyphilic / surgery. Adult. Aged. Aged, 80 and over. Angiomyolipoma / pathology. Angiomyolipoma / radiography. Angiomyolipoma / surgery. Carcinoma, Papillary / pathology. Carcinoma, Papillary / radiography. Carcinoma, Papillary / surgery. Carcinoma, Renal Cell / pathology. Carcinoma, Renal Cell / radiography. Carcinoma, Renal Cell / surgery. Disease Progression. Female. Humans. Male. Mathematical Computing. Middle Aged. Neoplasm Staging

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  • [CommentOn] Radiology. 2009 Jan;250(1):137-44 [19092093.001]
  • (PMID = 19561267.001).
  • [ISSN] 1527-1315
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
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42. Ozkara H, Ozkan B, Solok V: Management of renal abscess formation after embolization due to renal angiomyolipomas in two cases. Int Urol Nephrol; 2006;38(3-4):427-9
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  • [Title] Management of renal abscess formation after embolization due to renal angiomyolipomas in two cases.
  • Current management strategies of renal angiomyolipomas (AMLs) include observation, embolization and partial or total nephrectomy.
  • Percutaneous drainage was the recommended treatment for renal abscess formation following the embolization.
  • [MeSH-major] Abscess / etiology. Abscess / therapy. Angiomyolipoma / complications. Angiomyolipoma / therapy. Embolization, Therapeutic / adverse effects. Kidney Diseases / etiology. Kidney Diseases / therapy. Kidney Neoplasms / complications. Kidney Neoplasms / therapy. Staphylococcal Infections / etiology. Staphylococcal Infections / therapy


43. Phillips CK, Lepor H: Spontaneous retroperitoneal hemorrhage caused by segmental arterial mediolysis. Rev Urol; 2006;8(1):36-40
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  • Spontaneous retroperitoneal hemorrhage can be caused by tumors, such as renal cell carcinoma and angiomyolipoma; polyarteritis nodosa; and nephritis.
  • Although computed tomography is used for the diagnosis of spontaneous retroperitoneal hemorrhage, it can miss segmental arterial mediolysis as the cause of the hemorrhage.
  • The diagnosis of segmental arterial mediolysis as a cause of spontaneous retroperitoneal hemorrhage requires angiography, with pathologic confirmation for a definitive diagnosis.

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  • (PMID = 16985559.001).
  • [ISSN] 1523-6161
  • [Journal-full-title] Reviews in urology
  • [ISO-abbreviation] Rev Urol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1471764
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44. Linder B, Hong Y, Jarrett T: Intra-renal adrenal adenoma: a compelling addition to the differential diagnosis of renal mass. Int J Urol; 2009 Nov;16(11):912-4
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  • [Title] Intra-renal adrenal adenoma: a compelling addition to the differential diagnosis of renal mass.
  • We report a case of an adrenal rest arising in the kidney of a 37-year-old male.
  • Laparoscopic renal exploration and biopsy revealed angiomyolipoma on frozen section.
  • However, final pathological analysis of the partial nephrectomy specimen revealed intra-renal adrenal adenoma.
  • The diagnosis was confirmed by immunohistochemistries and transmission electron microscopy.
  • We review the reported literature on intra-renal adrenal adenoma and highlight the aspects that raise the index of suspicion for this entity on the differential diagnosis of renal masses.
  • [MeSH-major] Adenoma / diagnosis. Adrenal Gland Neoplasms / diagnosis. Kidney Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male. Neoplasm Invasiveness

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  • (PMID = 19863627.001).
  • [ISSN] 1442-2042
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Australia
  • [Number-of-references] 8
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45. Alvarez Alvarez C, Fernández Sanromán J, Fernández Castilla M, Antón Badiola I: Sporadic oral angiomyolipoma. Case report. Med Oral Patol Oral Cir Bucal; 2007 Sep;12(5):E391-3
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  • [Title] Sporadic oral angiomyolipoma. Case report.
  • Angiomyolipoma (AML) is a rare, benign tumour composed of a variable proportion of lipocytes, smooth muscle and thick-walled blood vessels.
  • AML is part of a family of tumours arising from perivascular epithelioid cells (PEComas), and many cases are associated with tuberous sclerosis, with the kidney being the most frequent site involved.
  • AML occurring in the head and neck do not express HMB-45, an antibody that identifies immature melanosomes, conversely to the usual immunopositivity shown in AMLs from kidney and liver, suggesting that there are differences among them.
  • [MeSH-major] Angiomyolipoma. Jaw Neoplasms. Palate, Hard

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  • (PMID = 17767105.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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46. Petrolla AA, MacLennan GT: Renal cell carcinoma and other concurrent renal neoplasms. J Urol; 2007 Nov;178(5):2163
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  • [Title] Renal cell carcinoma and other concurrent renal neoplasms.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Angiomyolipoma / pathology. Carcinoma, Renal Cell / pathology. Kidney Neoplasms / pathology. Neoplasms, Multiple Primary / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Nephrectomy. Prognosis

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  • (PMID = 17870118.001).
  • [ISSN] 0022-5347
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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47. Lu HC, Chau GY, Su CW: Clinical challenges and images in GI. Diagnosis: Hepatic angiomyolipoma mimicking hepatocellular carcinoma. Gastroenterology; 2009 Apr;136(4):1169, 1464
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  • [Title] Clinical challenges and images in GI. Diagnosis: Hepatic angiomyolipoma mimicking hepatocellular carcinoma.
  • [MeSH-major] Angiomyolipoma / diagnosis. Carcinoma, Hepatocellular / diagnosis. Liver Neoplasms / diagnosis
  • [MeSH-minor] Angiography. Biopsy, Fine-Needle. Diagnosis, Differential. Female. Hepatic Artery / radiography. Humans. Mesenteric Arteries / radiography. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 19254682.001).
  • [ISSN] 1528-0012
  • [Journal-full-title] Gastroenterology
  • [ISO-abbreviation] Gastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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48. Hadley DA, Bryant LJ, Ruckle HC: Conservative treatment of renal angiomyolipomas in patients with tuberous sclerosis. Clin Nephrol; 2006 Jan;65(1):22-7
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  • [Title] Conservative treatment of renal angiomyolipomas in patients with tuberous sclerosis.
  • AIMS: Renal angiomyolipoma (AML) associated with tuberous sclerosis (TS) presents a treatment dilemma due to multifocal tumors with a potential for significant growth and subsequent hemorrhage.
  • MATERIALS AND METHODS: We reviewed 8 patients (16 renal units) with bilateral renal AMLs and comorbid TS.
  • We evaluated their renal function, renal imaging, and clinical course.
  • The mean serum creatinine of these patients at the time of diagnosis was 0.75 mg/dl (range 0.4 - 1.1).
  • Of the 8 patients, 6 received treatment during the course of their disease, including arterial embolization of 7 renal units in 5 symptomatic patients (2 patients needed 2 embolizations).
  • Partial nephrectomy was performed on 2 renal units in 2 patients, and a total nephrectomy was performed in 1971 on another patient.
  • Currently, all 8 patients have stable renal function; 4 patients are asymptomatic with regards to their lesions, while the other 4 patients report transient flank pain adequately controlled with oral analgesics (2 patients with propoxyphene plus acetaminophen 100/650 mg PO t.i.d. p.r.n., the other 2 patients with ibuprofen 600 mg PO p.r.n.).
  • CONCLUSIONS: Our study and a review of the literature have not revealed an obvious or quantitative risk of morbidity or mortality from renal hemorrhage directly related to AMLs of any specific size in TS patients.
  • [MeSH-major] Angiomyolipoma / therapy. Kidney Neoplasms / therapy. Tuberous Sclerosis / complications

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  • (PMID = 16429838.001).
  • [ISSN] 0301-0430
  • [Journal-full-title] Clinical nephrology
  • [ISO-abbreviation] Clin. Nephrol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Analgesics; AYI8EX34EU / Creatinine
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49. Schieven LW, Smedts F, Hopman AH, van der Wijk J, Nijman RJ, de Jong IJ: Fine needle aspiration using improved agar microbiopsy is highly concordant with renal mass final diagnosis and subclassification. J Urol; 2009 Dec;182(6):2590-3
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  • [Title] Fine needle aspiration using improved agar microbiopsy is highly concordant with renal mass final diagnosis and subclassification.
  • PURPOSE: Computerized tomography and ultrasound are usually sufficient for preoperative evaluation of renal masses greater than 5 cm.
  • For renal masses less than 5 cm additional histological evaluation could improve diagnosis and treatment decisions.
  • We investigated the concordance between an improved agar microbiopsy technique and conventional cytology for diagnosing renal tumors.
  • MATERIALS AND METHODS: We performed fine needle aspiration in 40 renal masses after nephrectomy using a 22 gauge needle, obtaining multiple blind aspirations from the tumor surrounded by Gerota's fascia.
  • Cytology smears and agar microbiopsy sections were evaluated by 2 pathologists blinded to the definitive histological diagnosis.
  • RESULTS: The series consisted of 28 renal cell carcinomas, including 25 clear cell, 2 chromophobe and 1 papillary lesions, 7 urothelial cell carcinomas, 3 oncocytomas, 1 angiomyolipoma and 1 unclassified malignant tumor.
  • Agar microbiopsy was concordant with the final histological diagnosis in 39 of 40 cases (correlation 0.98).
  • CONCLUSIONS: Ex vivo fine needle aspiration using an improved agar microbiopsy block technique is highly concordant (98%) with the final diagnosis and subclassification of renal masses.
  • [MeSH-major] Biopsy, Fine-Needle / methods. Carcinoma, Renal Cell / classification. Carcinoma, Renal Cell / pathology. Kidney Neoplasms / classification. Kidney Neoplasms / pathology

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  • [CommentIn] J Urol. 2009 Dec;182(6):2594 [19836801.001]
  • (PMID = 19836783.001).
  • [ISSN] 1527-3792
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 9002-18-0 / Agar
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50. Linam LE, Yu X, Calvo-Garcia MA, Rubio EI, Crombleholme TM, Bove K, Kline-Fath BM: Contribution of magnetic resonance imaging to prenatal differential diagnosis of renal tumors: report of two cases and review of the literature. Fetal Diagn Ther; 2010;28(2):100-8
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  • [Title] Contribution of magnetic resonance imaging to prenatal differential diagnosis of renal tumors: report of two cases and review of the literature.
  • Enlargement of a kidney on prenatal imaging is usually due to hydronephrosis or cystic renal disease, and much less often results from solid tumors such as mesoblastic nephroma, Wilms' tumor, nephroblastomatosis, renal sarcoma, and angiomyolipoma.
  • Magnetic resonance imaging is useful not only in confirming the presence of a renal mass, but also in the evaluation of the contralateral kidney for subtle abnormalities.
  • [MeSH-major] Kidney Neoplasms / pathology. Nephroma, Mesoblastic / pathology. Prenatal Diagnosis / methods. Wilms Tumor / pathology
  • [MeSH-minor] Adolescent. Adult. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Pregnancy

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  • [Copyright] Copyright (c) 2010 S. Karger AG, Basel.
  • (PMID = 20587988.001).
  • [ISSN] 1421-9964
  • [Journal-full-title] Fetal diagnosis and therapy
  • [ISO-abbreviation] Fetal. Diagn. Ther.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Switzerland
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51. Wang HB, Yeh CL, Hsu KF: Spontaneous rupture renal angiomyolipoma with hemorrhagic shock. Intern Med; 2009;48(12):1111-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spontaneous rupture renal angiomyolipoma with hemorrhagic shock.
  • [MeSH-major] Angiomyolipoma / complications. Kidney Neoplasms / complications. Shock, Hemorrhagic / etiology

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  • (PMID = 19525611.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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52. Kim JY, Kim JK, Kim N, Cho KS: CT histogram analysis: differentiation of angiomyolipoma without visible fat from renal cell carcinoma at CT imaging. Radiology; 2008 Feb;246(2):472-9
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  • [Title] CT histogram analysis: differentiation of angiomyolipoma without visible fat from renal cell carcinoma at CT imaging.
  • PURPOSE: To retrospectively evaluate the diagnostic performance of computed tomographic (CT) histogram analysis for differentiating angiomyolipoma (AML) without visible fat from renal cell carcinoma (RCC) at CT, by using pathologic analysis and clinical diagnosis as the reference standard.
  • [MeSH-major] Adipose Tissue / radiography. Angiomyolipoma / radiography. Carcinoma, Renal Cell / radiography. Kidney Neoplasms / radiography. Radiographic Image Enhancement / methods. Radiographic Image Interpretation, Computer-Assisted / methods. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Algorithms. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Reproducibility of Results. Sensitivity and Specificity

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  • [Copyright] (c) RSNA, 2007.
  • (PMID = 18094264.001).
  • [ISSN] 1527-1315
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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53. Lee SY, Hsu HH, Chen YC, Huang CC, Wong YC, Wang LJ, Chuang CK, Yang CW: Embolization of renal angiomyolipomas: short-term and long-term outcomes, complications, and tumor shrinkage. Cardiovasc Intervent Radiol; 2009 Nov;32(6):1171-8
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  • [Title] Embolization of renal angiomyolipomas: short-term and long-term outcomes, complications, and tumor shrinkage.
  • This study retrospectively evaluated outcomes, complications, and tumor shrinkage in renal angiomyolipomas after transcatheter arterial embolization (TAE).
  • All renal angiomyolipoma patients who underwent TAE between August 2000 and December 2008 and had short-term (<or=6 months) or long-term (>6 months) follow-up images were evaluated.
  • Eleven renal angiomyolipoma patients who had undergone TAE were included.
  • In conclusion, selective TAE is effective for tumor shrinkage in most renal angiomyolipomas, with acceptable complication and relapse rates.
  • [MeSH-major] Angiomyolipoma / therapy. Embolization, Therapeutic / methods. Kidney Neoplasms / therapy

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  • (PMID = 19572171.001).
  • [ISSN] 1432-086X
  • [Journal-full-title] Cardiovascular and interventional radiology
  • [ISO-abbreviation] Cardiovasc Intervent Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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54. Johnson SC, Graham S, D'Agostino H, Elmajian DA, Shingleton WB: Percutaneous renal cryoablation of angiomyolipomas in patients with solitary kidneys. Urology; 2009 Dec;74(6):1246-9
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  • [Title] Percutaneous renal cryoablation of angiomyolipomas in patients with solitary kidneys.
  • OBJECTIVES: To determine the feasibility and safety of performing percutaneous cryoablation of angiomyolipomas (AMLs) in patients with solitary kidneys.
  • METHODS: Three patients with AMLs involving a solitary kidney underwent computed tomography-guided percutaneous cryoablation.
  • All lesions were located in the lateral/posterior part of the kidney, allowing for safe access from the skin for cryoprobe insertion.
  • CONCLUSIONS: A review of the published data suggested the necessity to prophylactically treat AMLs of solitary kidneys.
  • [MeSH-major] Angiomyolipoma / surgery. Cryosurgery. Kidney Neoplasms / surgery. Nephrectomy / methods

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  • (PMID = 19815260.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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55. Setola SV, Catalano O, Sandomenico F, Siani A: Contrast-enhanced sonography of the kidney. Abdom Imaging; 2007 Jan-Feb;32(1):21-8
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  • [Title] Contrast-enhanced sonography of the kidney.
  • Contrast-enhanced sonography (CEUS) is a recently introduced, promising technique in the evaluation of the kidney.
  • CEUS allows real-time assessment of normal and abnormal renal perfusions.
  • US contrast media are not nephrotoxic and can be employed safely, even in subjects with impaired renal function.
  • There are several clinical scenarios where CEUS may play the role of a low-cost, scarcely invasive tool, including renal tumors (with special reference to small, indeterminate masses, i.e., differentiation between carcinoma and angiomyolipoma), renal atypical cystic masses (i.e., differentiation of malignant from benign cysts and follow-up of cystic lesions managed conservatively), renal infarction, renal infections, and renal injuries.
  • In addition, CEUS can be useful in the assessment of renal pseudotumors (including any case with possible renal mass on conventional US imaging) and has been employed in radiofrequency ablation guidance.
  • This pictorial review illustrates the CEUS findings recognizable in a wide spectrum of renal disorders and discusses the strengths and limitations of renal imaging with CEUS.
  • [MeSH-major] Contrast Media. Image Enhancement / methods. Kidney / ultrasonography. Kidney Diseases / ultrasonography
  • [MeSH-minor] Adult. Aged. Angiomyolipoma / ultrasonography. Carcinoma / ultrasonography. Catheter Ablation. Female. Humans. Infarction / ultrasonography. Kidney Diseases, Cystic / ultrasonography. Kidney Neoplasms / ultrasonography. Male. Microbubbles. Microcirculation / ultrasonography. Middle Aged. Phospholipids. Pyelonephritis / ultrasonography. Sulfur Hexafluoride. Ultrasonography, Doppler / methods. Ultrasonography, Interventional

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  • (PMID = 17420958.001).
  • [ISSN] 0942-8925
  • [Journal-full-title] Abdominal imaging
  • [ISO-abbreviation] Abdom Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Phospholipids; 0 / contrast agent BR1; WS7LR3I1D6 / Sulfur Hexafluoride
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56. Sutter R, Boehler A, Willmann JK: Adrenal angiomyolipoma in lymphangioleiomyomatosis. Eur Radiol; 2007 Feb;17(2):565-6
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  • [Title] Adrenal angiomyolipoma in lymphangioleiomyomatosis.
  • [MeSH-major] Adrenal Gland Neoplasms / secondary. Angiomyolipoma / pathology. Lymphangioleiomyomatosis / pathology

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  • [Cites] Radiology. 2000 Jul;216(1):147-53 [10887241.001]
  • [Cites] Eur Respir J. 1996 Mar;9(3):402-5 [8729995.001]
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  • (PMID = 16586050.001).
  • [ISSN] 0938-7994
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Germany
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57. Morioka M, Kinugawa K, Funabiki S, Matsuda T, Furukawa Y, Wani Y: Monotypic epithelioid angiomyolipoma of the kidney: a case report. Int J Urol; 2006 Sep;13(9):1240-2
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  • [Title] Monotypic epithelioid angiomyolipoma of the kidney: a case report.
  • A case of monotypic variant of epithelioid angiomyolipoma (AML) observed in a 62-year old woman is reported.
  • The patient complained of abdominal fullness caused by a huge left renal mass without evidence of tuberous sclerosis complex.
  • Imaging studies showed a left renal mass with an area showing hemorrhage and necrosis.
  • The left renal mass, spleen and pancreatic tail were removed en bloc transabdominally.
  • As this tumor had none of the typical elements of classic AML, the final pathological diagnosis was monotypic epithelioid AML.
  • [MeSH-major] Angiomyolipoma / pathology. Kidney Neoplasms / pathology. Neoplasms, Glandular and Epithelial / pathology

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  • (PMID = 16984561.001).
  • [ISSN] 0919-8172
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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58. Shi H, Cao D, Wei L, Sun L, Guo A: Inflammatory angiomyolipomas of the liver: a clinicopathologic and immunohistochemical analysis of 5 cases. Ann Diagn Pathol; 2010 Aug;14(4):240-6
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  • Hepatic angiomyolipoma (AML) may demonstrate a marked histologic diversity.
  • [MeSH-major] Angiomyolipoma / pathology. Liver Neoplasms / pathology

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20637427.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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59. Boorjian SA, Sheinin Y, Crispen PL, Lohse CM, Leibovich BC, Kwon ED: T-cell co-regulatory molecule expression in renal angiomyolipoma and pulmonary lymphangioleiomyomatosis. Urology; 2009 Dec;74(6):1359-64
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  • [Title] T-cell co-regulatory molecule expression in renal angiomyolipoma and pulmonary lymphangioleiomyomatosis.
  • OBJECTIVES: To investigate the expression of B7-H3 and B7-H1 in renal angiomyolipoma (AML) tumors and the related, devastating syndrome of pulmonary lymphangioleiomyomatosis (LAM).
  • We recently reported the high expression of T-cell co-regulatory B7-H ligands in renal cell carcinoma tumor vasculature and tumor cells.
  • AML is a highly vascular tumor that most frequently emanates from the kidney.
  • METHODS: Immunohistochemical methods were used to assess the tumor expression of B7-H1 and B7-H3 in paraffin-embedded tissues from 110 patients who had undergone partial or radical nephrectomy for renal AML and from 7 patients with LAM who had undergone lung biopsy.
  • B7-H3 staining was noted in a median of 90% (range 20%-100%) of cells from renal AMLs and was independent of patient age (P = .43), sex (P = .27), tumor size (P = .21), and symptomatic presentation (P = .35).
  • CONCLUSIONS: B7-H3 was expressed at high levels in renal AMLs and pulmonary LAM, and B7-H1 was infrequently expressed in these tumors.
  • [MeSH-major] Angiomyolipoma / metabolism. Antigens, CD / biosynthesis. Kidney Neoplasms / metabolism. Lung Neoplasms / metabolism. Lymphangioleiomyomatosis / metabolism. Receptors, Immunologic / biosynthesis. T-Lymphocytes / metabolism

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  • (PMID = 19501877.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01 CA134345; United States / NCI NIH HHS / CA / R01 CA134345-01A1
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD274; 0 / B7 Antigens; 0 / CD274 protein, human; 0 / CD276 protein, human; 0 / Receptors, Immunologic
  • [Other-IDs] NLM/ NIHMS160050; NLM/ PMC2789880
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60. Pereverzev AS, Shchukin DV, Iliukhin IuA, Megera VV, Iaroslavskiĭ VL: [Spontaneous ruptures of renal tumors]. Urologiia; 2005 Mar-Apr;(2):21-4
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  • [Title] [Spontaneous ruptures of renal tumors].
  • For the last five years we treated 10 patients (7 females and 3 males) with spontaneous subcapsular or paranephral hematoma resultant from renal tumor rupture.
  • Morphologically, 4 tumors were renal angiomyolipoma and 6 tumors--renal cell carcinoma.
  • Left kidney tumor ruptures were more frequent (70%).
  • An accurate preoperative diagnosis was made in 70% cases with application of ultrasonic investigation, computed tomography, MR imaging, Of 4 patients with renal angiomyolipoma, conservative surgery (enucleation, enucleoresection) was conducted in 3 (75%) patients.
  • Of 6 patients with renal cell carcinoma, tumor removal with preservation of the kidney was feasible only in 1 (16.6%) patient, in the rest 5 patients radical nephrectomy was made.
  • Thus, patients with spontaneous rupture of renal tumors are characterized by absence of macrohematuria, prevalent location of the tumor on the left and in the middle segment of the kidney (90%), high diagnostic effectiveness of ultrasonography, no rise in local tumor recurrence consequently to rupture of the tumor tissue.
  • [MeSH-major] Angiomyolipoma / surgery. Carcinoma, Renal Cell / surgery. Hematoma / surgery. Kidney Neoplasms / surgery

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  • (PMID = 15989021.001).
  • [ISSN] 1728-2985
  • [Journal-full-title] Urologii︠a︡ (Moscow, Russia : 1999)
  • [ISO-abbreviation] Urologiia
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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61. Gupta P: Re: Imaging in renal lymphangiectasia: report of two cases and review of literature. Clin Radiol; 2009 May;64(5):564
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  • [Title] Re: Imaging in renal lymphangiectasia: report of two cases and review of literature.
  • [MeSH-major] Kidney Neoplasms / radiography. Lymphangiectasis / radiography
  • [MeSH-minor] Angiomyolipoma / radiography. Carcinoma, Renal Cell / radiography. Diagnosis, Differential. Humans. Tomography, X-Ray Computed

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  • [CommentOn] Clin Radiol. 2008 Sep;63(9):1057-62 [18718237.001]
  • (PMID = 19348856.001).
  • [ISSN] 1365-229X
  • [Journal-full-title] Clinical radiology
  • [ISO-abbreviation] Clin Radiol
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] England
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62. Takanami K, Kaneta T, Hitachi S, Yamada T, Ishida K, Rikiyama T, Katayose Y, Unno M, Yamada S, Takahashi S: F-18 FDG PET/CT findings in two patients with hepatic angiomyolipoma with and without intratumoral hemorrhage. Clin Nucl Med; 2010 Jan;35(1):18-21
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  • [Title] F-18 FDG PET/CT findings in two patients with hepatic angiomyolipoma with and without intratumoral hemorrhage.
  • [MeSH-major] Angiomyolipoma / diagnosis. Fluorodeoxyglucose F18. Hemorrhage / radionuclide imaging. Liver Neoplasms / diagnosis. Positron-Emission Tomography / methods. Tomography, X-Ray Computed / methods

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  • (PMID = 20026966.001).
  • [ISSN] 1536-0229
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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63. Huang YY, Wu HL, Tsou MY, Zong HJ, Guo WY, Chan KH, Ting CK: Paradoxical carbon dioxide embolism during pneumoperitoneum in laparoscopic surgery for a huge renal angiomyolipoma. J Chin Med Assoc; 2008 Apr;71(4):214-7
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  • [Title] Paradoxical carbon dioxide embolism during pneumoperitoneum in laparoscopic surgery for a huge renal angiomyolipoma.
  • We present a case of paradoxical gas embolism during CO2 insufflation in laparoscopic nephrectomy for a huge renal angiomyolipoma.
  • We speculate that rapid pneumoperitoneum introduction pushed CO2 into the abnormal vasculature of the angiomyolipoma, which communicates with the systemic vascular system, causing pseudoaneurysm formation.
  • Therefore, laparoscopic surgery for huge angiomyolipoma should be performed with extreme caution; an open procedure may be considered as an alternative.
  • [MeSH-major] Angiomyolipoma / surgery. Carbon Dioxide / adverse effects. Embolism, Air / etiology. Embolism, Paradoxical / etiology. Kidney Neoplasms / surgery. Laparoscopy / adverse effects. Pneumoperitoneum, Artificial / adverse effects

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  • (PMID = 18436506.001).
  • [ISSN] 1726-4901
  • [Journal-full-title] Journal of the Chinese Medical Association : JCMA
  • [ISO-abbreviation] J Chin Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
  • [Chemical-registry-number] 142M471B3J / Carbon Dioxide
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64. Yu W, Fraser RB, Gaskin DA, Fernandez CV, Wright JR Jr: C-Kit-positive metastatic malignant pigmented clear-cell epithelioid tumor arising from the kidney in a child without tuberous sclerosis. Ann Diagn Pathol; 2005 Dec;9(6):330-4
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  • [Title] C-Kit-positive metastatic malignant pigmented clear-cell epithelioid tumor arising from the kidney in a child without tuberous sclerosis.
  • We report the first pediatric case of malignant pigmented epithelioid clear-cell tumor arising from kidney; the lesion occurred in a 12-year-old girl without tuberous sclerosis.
  • The tumor was widely metastatic to the retroperitoneum and chest, and the patient died of the disease 9 months after diagnosis, despite active chemotherapy.
  • Pigmented epithelioid clear-cell tumor of the kidney is a rare variant of epithelioid angiomyolipoma and a member of the family of perivascular epithelioid cell tumors (PEComas).
  • The tumor demonstrated overlapping features between clear-cell sugar tumor and epithelioid variant of angiomyolipoma.
  • [MeSH-major] Angiomyolipoma / metabolism. Kidney Neoplasms / metabolism. Proto-Oncogene Proteins c-kit / metabolism

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  • (PMID = 16308163.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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65. Wang KL, Weinrach DM, Luan C, Han M, Lin F, Teh BT, Yang XJ: Renal papillary adenoma--a putative precursor of papillary renal cell carcinoma. Hum Pathol; 2007 Feb;38(2):239-46
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  • [Title] Renal papillary adenoma--a putative precursor of papillary renal cell carcinoma.
  • The precursor lesions of renal cell carcinoma (RCC) are unknown.
  • Seven papillary adenomas (18%) occurred in the setting of acquired polycystic kidney disease (APKD), 6 in clear-cell RCCs, 3 in chromophobe RCCs, 2 in end-stage kidney disease, 1 in oncocytoma, 1 in angiomyolipoma, and 1 in renal schwannoma.
  • Furthermore, papillary adenomas were more commonly found in kidneys removed for PRCC (25%, 18/71) than in kidneys harboring clear-cell RCC (1.9%, 6/318).
  • [MeSH-major] Carcinoma, Papillary / pathology. Carcinoma, Renal Cell / pathology. Kidney Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma, Clear Cell / enzymology. Adenocarcinoma, Clear Cell / pathology. Adenoma. Adenoma, Oxyphilic / enzymology. Adenoma, Oxyphilic / pathology. Adult. Aged. Aged, 80 and over. Angiomyolipoma / enzymology. Angiomyolipoma / pathology. Disease Progression. Female. Glutathione Transferase / analysis. Humans. Immunohistochemistry. Isoenzymes / analysis. Kidney / enzymology. Kidney / pathology. Kidney Failure, Chronic / enzymology. Kidney Failure, Chronic / pathology. Male. Middle Aged. Models, Biological. Polycystic Kidney Diseases / enzymology. Polycystic Kidney Diseases / pathology. Racemases and Epimerases / analysis

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  • (PMID = 17056094.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Isoenzymes; EC 2.5.1.18 / Glutathione Transferase; EC 2.5.1.18 / glutathione S-transferase alpha; EC 5.1.- / Racemases and Epimerases; EC 5.1.99.4 / alpha-methylacyl-CoA racemase
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66. Pereverzev AS, Shchukin DV, Iliukhin IuA, Iaroslavskiĭ VL, Mys'ko SIa, Megera VV: [Renal tumors and pregnancy]. Urologiia; 2005 May-Jun;(3):3-6
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  • [Title] [Renal tumors and pregnancy].
  • The article presents a retrospective analysis of literature data on combination of renal tumors with pregnancy, three cases are reported.
  • Basic therapeutic algorithm of renal angiomyolipoma is follow-up.
  • [MeSH-major] Kidney Neoplasms / surgery. Kidney Neoplasms / ultrasonography. Nephrectomy. Pregnancy Complications, Neoplastic / surgery. Pregnancy Complications, Neoplastic / ultrasonography

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  • (PMID = 16100783.001).
  • [ISSN] 1728-2985
  • [Journal-full-title] Urologii︠a︡ (Moscow, Russia : 1999)
  • [ISO-abbreviation] Urologiia
  • [Language] rus
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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67. Katada Y, Umehara I, Ohki T, Kishino M, Shibuya H: Bilateral renal angiomyolipoma in a patient with tuberous sclerosis treated with resection of one kidney and transarterial embolization of other kidney using CT during selective arteriography: a case report. Cases J; 2009;2:6351
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  • [Title] Bilateral renal angiomyolipoma in a patient with tuberous sclerosis treated with resection of one kidney and transarterial embolization of other kidney using CT during selective arteriography: a case report.
  • Renal AML complicating tuberous sclerosis shows a rapid growth and its rupture is frequently associated with hemorrhagic shock as a result of profuse retroperitoneal bleeding, necessitating an aggressive therapeutic approach.
  • This report describes the long-term clinical progress of 28 year-old woman with tuberous sclerosis with a ruptured giant AML that underwent unilateral nephrectomy, who has been followed up after treatment with concomitant application of computed tomography during selective arteriography to conserve the remaining normal renal parenchyma, and in whom the need for initiation of dialysis has been successfully avoided, with conspicuous reduction of the tumor size.

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  • [Cites] J Urol. 1977 Jan;117(1):122-3 [830960.001]
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  • (PMID = 19829792.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2740105
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68. Colović R, Colović N, Grubor N, Radak V, Micev M, Stojković M: [Bilateral angiomyolipoma of the kidney in patient with tuberous sclerosis]. Srp Arh Celok Lek; 2005 Sep-Oct;133(9-10):433-7
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  • [Title] [Bilateral angiomyolipoma of the kidney in patient with tuberous sclerosis].
  • Angiomyolipomas are relatively frequent tumours of the kidney.
  • Due to the benign nature of angiomyolipomas, surgical treatment and embolisation of the tumours are generally not recommended, unless renal function is endangered, the symptoms are severe, or the kidney in question becomes completely dysfunctional.
  • We present a 24-year-old woman with tuberous sclerosis in whom bilateral kidney tumours were diagnosed 7 years earlier and in whom we carried out a left nephrectomy of a 5300 gram angiomyolipoma, which caused pain and complete loss of function.
  • Although tumourous, the right kidney was functional, so it was left untouched.
  • After an uneventful recovery, a close follow-up was recommended, as well as HLA typing, as it is highly probable that the right kidney will gradually become inadequate or completely dysfunctional, so that haemodialysis and/or kidney transplantation along with nephrectomy will become necessary.
  • [MeSH-major] Angiomyolipoma / complications. Kidney Neoplasms / complications. Tuberous Sclerosis / complications

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  • (PMID = 16640189.001).
  • [ISSN] 0370-8179
  • [Journal-full-title] Srpski arhiv za celokupno lekarstvo
  • [ISO-abbreviation] Srp Arh Celok Lek
  • [Language] srp
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Serbia and Montenegro
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69. Blick C, Ravindranath N, Muneer A, Jones A: Bilateral renal angiomyolipomas with invasion of the renal vein: a case report. ScientificWorldJournal; 2008;8:145-8
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  • [Title] Bilateral renal angiomyolipomas with invasion of the renal vein: a case report.
  • An angiomyolipoma (AML) is usually a benign, rare, and, more commonly, a unilateral renal tumour.
  • [MeSH-major] Angiomyolipoma / pathology. Kidney Neoplasms / pathology. Renal Veins / pathology

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  • (PMID = 18264631.001).
  • [ISSN] 1537-744X
  • [Journal-full-title] TheScientificWorldJournal
  • [ISO-abbreviation] ScientificWorldJournal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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70. Ramírez Daniel L, García Sabela L, Rey Jorge R, Calvo Antonio O: [Retroperitoneal angiomyolipoma: review of the literature and report of a new case]. Actas Urol Esp; 2010 Oct;34(9):815-7
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  • [Title] [Retroperitoneal angiomyolipoma: review of the literature and report of a new case].
  • [Transliterated title] Angiomiolipoma retroperitoneal: revisión de la literatura y reporte de un nuevo caso.
  • [MeSH-major] Angiomyolipoma. Puerperal Disorders. Retroperitoneal Neoplasms

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  • (PMID = 20843462.001).
  • [ISSN] 1699-7980
  • [Journal-full-title] Actas urologicas españolas
  • [ISO-abbreviation] Actas Urol Esp
  • [Language] spa
  • [Publication-type] Case Reports; Letter; Review
  • [Publication-country] Spain
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71. Sukumar S, Balagopal Nair T, Mohammed Saheed CS, Sanjay Bhat H: Bilateral nephron sparing surgeries for multiple renal angiomyolipomas in Bourneville's disease. Int Urol Nephrol; 2007;39(2):389-91
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  • [Title] Bilateral nephron sparing surgeries for multiple renal angiomyolipomas in Bourneville's disease.
  • INTRODUCTION: Angiomyolipomas are the most common renal lesions in tuberous sclerosis complex.
  • CASE-HISTORY: A 22-year-old lady with bilateral multiple large symptomatic renal angiomyolipomas associated with other manifestations of tuberous sclerosis was managed with partial nephrectomies on either side.
  • At 30 months of follow-up, the patient has normal renal functions and no evidence of recurrence.
  • DISCUSSION: Intervention for renal angiomyolipomas is indicated in symptomatic tumors larger than four centimetres.
  • Nephron sparing surgery of both kidneys for angiomyolipomas in association with tuberous sclerosis has only been sparingly reported in literature.
  • [MeSH-major] Angiomyolipoma / surgery. Kidney Neoplasms / surgery. Nephrectomy / methods. Tuberous Sclerosis / complications

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  • (PMID = 17004032.001).
  • [ISSN] 0301-1623
  • [Journal-full-title] International urology and nephrology
  • [ISO-abbreviation] Int Urol Nephrol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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72. Habib SL: Insight into mechanism of oxidative DNA damage in angiomyolipomas from TSC patients. Mol Cancer; 2009;8:13
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  • TSC-2 gene encodes tuberin, a protein involved in the pathogenesis of kidney tumors, both angiomyolipomas and renal cell carcinomas.
  • Loss of heterozygosity at the 8-oxoG-DNA glycosylase (OGG1) allele is found in human kidney clear cell carcinoma identifying loss of OGG1 function as a possible contributor to tumorigenesis in the kidney.
  • The purpose of this study is to determine the effect of tuberin-deficiency on OGG1 protein and mRNA levels as well as on 8-oxodG levels in kidney tumors from patients with TSC.
  • In addition we evaluated the phophorylation level of downstream targets of mTOR, phospho-S70K, in kidney tumor tissue from TSC patients.
  • RESULTS: Kidney angiomyolipoma tissue from TSC patients expresses significant levels of phopho-tuberin and low levels of tuberin compared to control kidney tissue.
  • The increase in tuberin phosphorylation and the decrease tuberin expression are associated with decrease in OGG1 protein and mRNA levels in tumor samples compared to normal kidney samples.
  • Cyclin D1 expression is also 3-fold higher in increase in the tumor tissues compared to normal kidney tissues.
  • CONCLUSION: These data indicate that tuberin deficiency in angiomyolipoma enhances mTOR activation by phosphorylation of S6K and downregulation of protein and mRNA expression of OGG1 resulted in accumulation of oxidized DNA in patients with TSC.
  • These data suggest that tuberin and OGG1 are important proteins in the pathogenesis of angiomyolipoma in TSC patients.
  • [MeSH-major] Angiomyolipoma / genetics. Angiomyolipoma / metabolism. DNA Damage / physiology. DNA Glycosylases / metabolism. Tuberous Sclerosis / genetics. Tuberous Sclerosis / metabolism
  • [MeSH-minor] Animals. CCAAT-Binding Factor / metabolism. Cell Line. Cyclin D1 / metabolism. Deoxyguanosine / analogs & derivatives. Deoxyguanosine / metabolism. Humans. Immunoblotting. In Vitro Techniques. Kidney / metabolism. Kidney / pathology. Mice. Oxidative Stress. Phosphorylation. Protein Kinases / metabolism. Rats. Reverse Transcriptase Polymerase Chain Reaction. TOR Serine-Threonine Kinases. Tumor Suppressor Proteins / metabolism. Tumor Suppressor Proteins / physiology

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  • (PMID = 19265534.001).
  • [ISSN] 1476-4598
  • [Journal-full-title] Molecular cancer
  • [ISO-abbreviation] Mol. Cancer
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / P50 DK061597
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CCAAT-Binding Factor; 0 / NFYA protein, human; 0 / Tumor Suppressor Proteins; 136601-57-5 / Cyclin D1; 4JG2LF96VF / tuberous sclerosis complex 2 protein; 88847-89-6 / 8-oxo-7-hydrodeoxyguanosine; EC 2.7.- / Protein Kinases; EC 2.7.1.1 / MTOR protein, human; EC 2.7.1.1 / TOR Serine-Threonine Kinases; EC 2.7.1.1 / mTOR protein, mouse; EC 3.2.2.- / DNA Glycosylases; EC 3.2.2.- / oxoguanine glycosylase 1, human; G9481N71RO / Deoxyguanosine
  • [Other-IDs] NLM/ PMC2657104
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73. Parikh P, Chan TY, Epstein JI, Argani P: Incidental stromal-predominant mixed epithelial-stromal tumors of the kidney: a mimic of intraparenchymal renal leiomyoma. Arch Pathol Lab Med; 2005 Jul;129(7):910-4
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  • [Title] Incidental stromal-predominant mixed epithelial-stromal tumors of the kidney: a mimic of intraparenchymal renal leiomyoma.
  • CONTEXT: Mixed epithelial-stromal tumor of the kidney is a recently recognized benign renal tumor that usually occurs in adult women and typically forms a sizable lesion with solid and cystic areas.
  • OBJECTIVE: To review the clinicopathologic features of 3 small mixed epithelial-stromal tumors of the kidney that were incidental findings in kidneys removed for other reasons.
  • CONCLUSIONS: Mixed epithelial-stromal tumor of the kidney may present as an incidental stromal-predominant lesion within the kidney.
  • [MeSH-major] Angiomyolipoma / diagnosis. Kidney Neoplasms / diagnosis. Leiomyoma / diagnosis. Neoplasms, Complex and Mixed / diagnosis. Neoplasms, Glandular and Epithelial / diagnosis. Smooth Muscle Tumor / diagnosis. Stromal Cells / pathology
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Female. Humans. Middle Aged

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  • (PMID = 15974815.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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74. Morton JM, McLean C, Booth SS, Snell GI, Whitford HM: Regression of pulmonary lymphangioleiomyomatosis (PLAM)-associated retroperitoneal angiomyolipoma post-lung transplantation with rapamycin treatment. J Heart Lung Transplant; 2008 Apr;27(4):462-5
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  • [Title] Regression of pulmonary lymphangioleiomyomatosis (PLAM)-associated retroperitoneal angiomyolipoma post-lung transplantation with rapamycin treatment.
  • Computed tomography (CT) scan demonstrated no pulmonary abnormality, but identified a retroperitoneal mass confirmed as angiomyolipoma by CT-guided core biopsy.
  • Based on experimental work that rapamycin may inhibit angiomyolipoma cells, we commenced the patient on low-dose rapamycin.
  • [MeSH-major] Angiomyolipoma / drug therapy. Antibiotics, Antineoplastic / therapeutic use. Lung Neoplasms / surgery. Lung Transplantation. Lymphangioleiomyomatosis / surgery. Neoplasms, Second Primary. Retroperitoneal Neoplasms / drug therapy. Sirolimus / therapeutic use

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  • [CommentIn] J Heart Lung Transplant. 2008 Nov;27(11):1268 [18971103.001]
  • (PMID = 18374885.001).
  • [ISSN] 1557-3117
  • [Journal-full-title] The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
  • [ISO-abbreviation] J. Heart Lung Transplant.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; W36ZG6FT64 / Sirolimus
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75. Green DE, Woodward PJ: The management of indeterminate incidental findings detected at abdominal CT. Semin Ultrasound CT MR; 2005 Feb;26(1):2-13
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  • Some of these findings can be characterized without additional imaging (including simple renal cyst, angiomyolipoma, hepatic steatosis).
  • While some of these indeterminate incidental findings can be ignored based on statistical arguments (for example, a sharply circumscribed homogeneous low-attenuation renal lesion under 1 cm in patients without a predisposition to develop renal cell carcinoma), many may need additional imaging studies to either characterize them or demonstrate stability over time.
  • [MeSH-major] Abdominal Neoplasms / diagnosis. Abdominal Neoplasms / therapy. Digestive System Diseases / diagnosis. Digestive System Diseases / therapy. Incidental Findings. Radiography, Abdominal / methods
  • [MeSH-minor] Aortic Aneurysm / diagnosis. Aortic Aneurysm / therapy. Cysts / diagnosis. Cysts / therapy. Digestive System / radiography. Humans. Tomography, X-Ray Computed / methods

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  • (PMID = 15771259.001).
  • [ISSN] 0887-2171
  • [Journal-full-title] Seminars in ultrasound, CT, and MR
  • [ISO-abbreviation] Semin. Ultrasound CT MR
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 60
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76. Matuszewski M, Michajłowski J, Bianek-Bodzak A, Krajka K: Radiofrequency ablation of small symptomatic angiomyolipomas of the kidney: Report of two cases. Pol J Radiol; 2010 Jul;75(3):68-71
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  • [Title] Radiofrequency ablation of small symptomatic angiomyolipomas of the kidney: Report of two cases.
  • BACKGROUND: The development of more sensitive imaging techniques caused an increase in the number of diagnosed small renal tumors.
  • AML is a rare benign tumor of the kidney, sometimes causing pain and hematuria.
  • This paper demonstrated the evolution of our attitude leading to utilization of radiofrequency ablation (RFA) as a minimally invasive option in the management of small symptomatic AMLs of the kidneys.
  • MATERIAL/METHODS: We presented clinical data of two cases of symptomatic AML tumors in the kidney, treated with RFA.
  • RESULTS: RFA proved to be an effective and safe method of treatment of renal AMLs.

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  • [Cites] AJR Am J Roentgenol. 1988 Sep;151(3):497-501 [3044036.001]
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  • (PMID = 22802796.001).
  • [ISSN] 1733-134X
  • [Journal-full-title] Polish journal of radiology
  • [ISO-abbreviation] Pol J Radiol
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] Poland
  • [Other-IDs] NLM/ PMC3389883
  • [Keywords] NOTNLM ; RFA / angiomyolipoma of the kidney / minimally invasive treatment
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77. Larrea JS, Pino LB, Cabrera RS, Mena AL: Urological conservative management of a patient with tuberous sclerosis complex (Bourneville disease). Arch Esp Urol; 2009 Sep;62(7):596-9
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  • OBJECTIVE: To report the clinical and radiological data of a 23-year-woman with bilateral angiomyolipoma and Tuberous Sclerosis with conservative treatment.
  • CONCLUSIONS: Renal lesions associated with tuberous sclerosis are frequent and serious.
  • Monitoring should be based on a careful monitoring since the renal lesions are the second death cause after the lesions of the nervous system.
  • [MeSH-major] Angiomyolipoma / therapy. Kidney Neoplasms / therapy. Tuberous Sclerosis / complications


78. Zhou YM, Li B, Xu F, Wang B, Li DQ, Zhang XF, Liu P, Yang JM: Clinical features of hepatic angiomyolipoma. Hepatobiliary Pancreat Dis Int; 2008 Jun;7(3):284-7
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  • [Title] Clinical features of hepatic angiomyolipoma.
  • BACKGROUND: Hepatic angiomyolipoma (HAML) is a rare hepatic mesenchymal tumor.
  • Pre-operative diagnosis was made in only 3 patients.
  • CONCLUSIONS: Pre-operative diagnosis of HAML is difficult.
  • [MeSH-major] Angiomyolipoma / pathology. Hepatectomy / methods. Liver Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Antigens, Neoplasm / metabolism. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Immunohistochemistry. Male. Melanoma-Specific Antigens. Middle Aged. Neoplasm Proteins / metabolism. Neoplasm Staging. Prognosis. Retrospective Studies

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  • (PMID = 18522883.001).
  • [ISSN] 1499-3872
  • [Journal-full-title] Hepatobiliary & pancreatic diseases international : HBPD INT
  • [ISO-abbreviation] HBPD INT
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins
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79. Hoda MR, Popken G: Surgical outcomes of fluorescence-guided laparoscopic partial nephrectomy using 5-aminolevulinic acid-induced protoporphyrin IX. J Surg Res; 2009 Jun 15;154(2):220-5
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  • A total of 77 patients with a renal mass < 4 cm diameter underwent laparoscopic partial nephrectomy (LPN).
  • Fifty-eight of 61 (95.1%) renal cell carcinomas showed a positive response when exposed to excitation light.
  • However, characteristic fluorescence was also detected in 1 angiomyolipoma of 16 nonmalignant lesions.
  • CONCLUSIONS: PDD after systemic administration of 5-ALA is a reliable tool to assess the type and the resection status of a suspected renal tumor during laparoscopic nephron-sparing surgery.
  • [MeSH-major] Aminolevulinic Acid. Carcinoma, Renal Cell / pathology. Carcinoma, Renal Cell / surgery. Kidney Neoplasms / pathology. Kidney Neoplasms / surgery. Nephrectomy / methods. Photosensitizing Agents

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  • (PMID = 19375717.001).
  • [ISSN] 1095-8673
  • [Journal-full-title] The Journal of surgical research
  • [ISO-abbreviation] J. Surg. Res.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Photosensitizing Agents; 0 / Protoporphyrins; 553-12-8 / protoporphyrin IX; 88755TAZ87 / Aminolevulinic Acid
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80. Katayama K, Hayashi T, Tsutahara K, Matsuoka A, Fujimoto N, Koide T: [Bilateral giant renal angiomyolipoma following hemodialysis in a patient with tuberous sclerosis]. Hinyokika Kiyo; 2009 Jun;55(6):335-8
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  • [Title] [Bilateral giant renal angiomyolipoma following hemodialysis in a patient with tuberous sclerosis].
  • She had been diagnosed with bilateral renal angiomyolipoma (AML) when she was 32 years old and had been on maintenance hemodialysis since the age of 44.
  • Magnetic resonance imaging showed bilateral giant renal AML and hemorrhage in the AML of the left kidney.
  • The histological diagnosis was consistent with AML.
  • In addition, the Japanese literature on giant renal AML was reviewed and discussed.
  • [MeSH-major] Angiomyolipoma / etiology. Kidney Neoplasms / etiology. Renal Dialysis. Tuberous Sclerosis / complications


81. Dillon RC, Friedman AC, Miller FH: MR signal intensity calculations are not reliable for differentiating renal cell carcinoma from lipid poor angiomyolipoma. Radiology; 2010 Oct;257(1):299-300; author reply 300
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  • [Title] MR signal intensity calculations are not reliable for differentiating renal cell carcinoma from lipid poor angiomyolipoma.
  • [MeSH-major] Angiomyolipoma / pathology. Carcinoma, Renal Cell / pathology. Kidney Neoplasms / pathology. Magnetic Resonance Imaging / methods
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Middle Aged


82. Németh I, Sükösd F, Béli L, Kiss A, Pajor L, Mikó T, Iványi B: [Adult renal neoplasms in the material of the Pathology Department of the Szeged University]. Orv Hetil; 2005 Apr 3;146(14):653-8
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  • [Title] [Adult renal neoplasms in the material of the Pathology Department of the Szeged University].
  • AIMS: The authors investigated the frequencies of the various histological types of adult renal tumours.
  • Among the malignant tumours, the frequency of renal cell carcinomas was 91.1% (n = 371).
  • 88.4% of the renal cell carcinomas (n = 328) were of conventional type, 5.6% (n = 21) were papillary and 4% (n = 15) were chromophobe.
  • CONCLUSIONS: Adult malignant renal tumours affect mainly patients around the age of 60.
  • The commonest diagnosis was clear cell carcinoma of conventional type.
  • In comparison with the literature data, oncocytomas were relatively common (8% instead of 3%), and not rarely, it was difficult to distinguish them from renal cell carcinomas.
  • [MeSH-major] Carcinoma / epidemiology. Carcinoma / pathology. Kidney Neoplasms / epidemiology. Kidney Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma, Clear Cell / epidemiology. Adenocarcinoma, Clear Cell / pathology. Adenoma, Chromophobe / epidemiology. Adenoma, Chromophobe / pathology. Adenoma, Oxyphilic / epidemiology. Adenoma, Oxyphilic / pathology. Adult. Aged. Angiomyolipoma / epidemiology. Angiomyolipoma / pathology. Carcinoma, Papillary / epidemiology. Carcinoma, Papillary / pathology. Carcinoma, Renal Cell / epidemiology. Carcinoma, Renal Cell / pathology. Carcinoma, Transitional Cell / epidemiology. Carcinoma, Transitional Cell / pathology. Female. Humans. Hungary / epidemiology. Male. Middle Aged. Nephrectomy

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  • (PMID = 15889540.001).
  • [ISSN] 0030-6002
  • [Journal-full-title] Orvosi hetilap
  • [ISO-abbreviation] Orv Hetil
  • [Language] hun
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Hungary
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83. Ben Hamida F, Gorsane I, Gharbi C, Kaaroud H, Barbouch S, Smaoui W, Helal I, Beji S, Goucha R, Hedri H, Ben Moussa F, Ben Abdallah T, Ben Maiz H, Kheder A: [Renal manifestations in tuberous sclerosis]. Rev Med Interne; 2006 Nov;27(11):836-42
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  • [Title] [Renal manifestations in tuberous sclerosis].
  • Renal involvement is one of the most severe manifestations of the disease.
  • We analysed in this study renal involvement of tuberous sclerosis.
  • METHODS: We studied retrospectively nine cases of tuberous sclerosis with renal involvement diagnosed between 1994 and 2005.
  • The diagnosis was based on the presence of typical extra-renal manifestations and familial history of tuberous sclerosis.
  • At first presentation, we noted hypertension in three cases, proteinuria in seven cases, hematuria in eight cases and renal failure in five cases (end stage renal failure in four cases).
  • By ultrasonography, we found angiomyolipoma in one case, cysts in four cases and angiomyolipoma associated to cysts in four cases.
  • In the later, pathological examination revealed renal carcinoma.
  • At last evaluation, two patients were lost to follow-up, one had normal serum creatinine, five were on renal replacement therapy and the latter died from sepsis following kidney removal.
  • CONCLUSIONS: In our patients, renal disease was diagnosed late at chronic renal failure stage.
  • Patients with end-stage renal failure require dialysis and renal transplantation, but we recommend binephrectomy after starting dialysis and before transplantation due to the risk of cancer and bleeding related to angiomyolipomas.


84. Peces R, Peces C, Cuesta-López E, Pérez-Dueñas V, Vega-Cabrera C, Azorín S, Selgas R: Low-dose rapamycin reduces kidney volume angiomyolipomas and prevents the loss of renal function in a patient with tuberous sclerosis complex. Nephrol Dial Transplant; 2010 Nov;25(11):3787-91
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  • [Title] Low-dose rapamycin reduces kidney volume angiomyolipomas and prevents the loss of renal function in a patient with tuberous sclerosis complex.
  • Tuberous sclerosis complex (TSC) is caused by constitutively activated mammalian target of rapamycin (mTOR) resulting in non-malignant tumours of several organs including renal angiomyolipomas (AMLs).
  • AMLs may originate renal failure, hypertension and spontaneous life-threatening bleeding.
  • A 40-year-old man with sporadic TSC and a history of spontaneous bleeding from his left kidney AMLs received low-dose rapamycin for 12 months, and this was associated with a reduction in bilateral kidney AML volume, stabilization and even improvement of renal function.
  • To the best of our knowledge, this is the first report of a case of reduction in renal AML volume together with preservation of renal function in a patient with TSC receiving low-dose rapamycin.
  • [MeSH-major] Angiomyolipoma / drug therapy. Kidney Neoplasms / drug therapy. Sirolimus / therapeutic use. TOR Serine-Threonine Kinases / antagonists & inhibitors. Tuberous Sclerosis / drug therapy
  • [MeSH-minor] Adult. Humans. Kidney / pathology. Kidney / physiopathology. Magnetic Resonance Imaging. Male

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  • (PMID = 20663789.001).
  • [ISSN] 1460-2385
  • [Journal-full-title] Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
  • [ISO-abbreviation] Nephrol. Dial. Transplant.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] EC 2.7.1.1 / TOR Serine-Threonine Kinases; W36ZG6FT64 / Sirolimus
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85. Fujii T, Zen Y, Sato Y, Sasaki M, Enomae M, Minato H, Masuda S, Uehara T, Katsuyama T, Nakanuma Y: Podoplanin is a useful diagnostic marker for epithelioid hemangioendothelioma of the liver. Mod Pathol; 2008 Feb;21(2):125-30
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  • In this study, we examined podoplanin expression in specimens from 10 normal livers and 73 cases of liver tumors: hemangioma (16 cases), epithelioid hemangioendothelioma (9 cases), angiosarcoma (4 cases), angiomyolipoma (7 cases), hepatocellular carcinoma (11 cases), intrahepatic cholangiocarcinoma (11 cases), and metastatic liver cancer (15 cases).
  • The expression of CD31, CD34, and factor VIII was observed in endothelial cells in all cases of hemangioma, epithelioid hemangioendothelioma, angiosarcoma, and angiomyolipoma with one exception, a case of epithelioid hemangioendothelioma which was without CD31 expression.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Angiomyolipoma / metabolism. Angiomyolipoma / pathology. Bile Duct Neoplasms / metabolism. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / metabolism. Bile Ducts, Intrahepatic / pathology. Carcinoma, Hepatocellular / metabolism. Carcinoma, Hepatocellular / pathology. Cholangiocarcinoma / metabolism. Cholangiocarcinoma / pathology. Diagnosis, Differential. Endothelium, Lymphatic / metabolism. Endothelium, Lymphatic / pathology. Female. Hemangioma / metabolism. Hemangioma / pathology. Hemangiosarcoma / metabolism. Hemangiosarcoma / pathology. Humans. Liver / metabolism. Liver / pathology. Male. Middle Aged

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  • (PMID = 18084256.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Membrane Glycoproteins; 0 / PDPN protein, human
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86. Yen YH, Wang JH, Lu SN, Changchien CS: Contrast-enhanced ultrasonography in hepatic angiomyolipoma. J Ultrasound Med; 2005 Jun;24(6):855-9
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  • [Title] Contrast-enhanced ultrasonography in hepatic angiomyolipoma.
  • [MeSH-major] Angiomyolipoma / ultrasonography. Liver Neoplasms / ultrasonography. Ultrasonography, Doppler / methods
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Image Enhancement. Male. Tomography, X-Ray Computed

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  • (PMID = 15914690.001).
  • [ISSN] 0278-4297
  • [Journal-full-title] Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
  • [ISO-abbreviation] J Ultrasound Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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87. Chang MH, Yao-Peng H: Lymphangioleiomyomatosis, multifocal micronodular pneumocyte hyperplasia, and clear-cell micronodules in a 39-year-old woman with tuberous sclerosis: a case report. Int J Surg Pathol; 2010 Dec;18(6):522-5
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  • Bilateral renal angiomyolipomas (AMLs) and cerebral periventricular spots were also present.
  • [MeSH-minor] Adult. Angiomyolipoma / complications. Angiomyolipoma / pathology. Female. Humans. Hyperplasia / complications. Hyperplasia / pathology. Kidney Neoplasms / complications. Kidney Neoplasms / pathology. Perivascular Epithelioid Cell Neoplasms / complications. Perivascular Epithelioid Cell Neoplasms / pathology


88. Siroky BJ, Czyzyk-Krzeska MF, Bissler JJ: Renal involvement in tuberous sclerosis complex and von Hippel-Lindau disease: shared disease mechanisms? Nat Clin Pract Nephrol; 2009 Mar;5(3):143-56
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  • [Title] Renal involvement in tuberous sclerosis complex and von Hippel-Lindau disease: shared disease mechanisms?
  • Tuberous sclerosis complex and von Hippel-Lindau disease are distinct autosomal dominant tumor suppressor syndromes that can exhibit similar renal phenotypes and seem to share some signaling pathway components.
  • [MeSH-major] Kidney Diseases, Cystic / genetics. Kidney Neoplasms / genetics. Tuberous Sclerosis / genetics. von Hippel-Lindau Disease / genetics
  • [MeSH-minor] Adenoma, Oxyphilic / genetics. Angiomyolipoma / genetics. Carcinoma, Renal Cell / genetics. Cell Proliferation. Humans. Hypoxia-Inducible Factor 1 / metabolism. Signal Transduction. Tumor Suppressor Proteins / metabolism

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  • (PMID = 19240728.001).
  • [ISSN] 1745-8331
  • [Journal-full-title] Nature clinical practice. Nephrology
  • [ISO-abbreviation] Nat Clin Pract Nephrol
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA122346; United States / NIDDK NIH HHS / DK / DK061458; United States / PHS HHS / / DODPR064135; United States / PHS HHS / / DODTS050008
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Hypoxia-Inducible Factor 1; 0 / Tumor Suppressor Proteins
  • [Number-of-references] 148
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89. Schachter LR, Cookson MS, Chang SS, Smith JA Jr, Dietrich MS, Jayaram G, Herrell SD: Second prize: frequency of benign renal cortical tumors and histologic subtypes based on size in a contemporary series: what to tell our patients. J Endourol; 2007 Aug;21(8):819-23
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  • [Title] Second prize: frequency of benign renal cortical tumors and histologic subtypes based on size in a contemporary series: what to tell our patients.
  • BACKGROUND AND PURPOSE: Historically, 85% to 90% of renal masses have been malignant, with the majority being renal-cell carcinoma.
  • However, with the increasing frequency of incidentally discovered renal masses, only 70% to 85% of lesions are found to be malignant.
  • This study sought to determine the incidence of the various histologic subtypes of renal cortical tumors according to size in a contemporary series of surgically treated patients.
  • MATERIALS AND METHODS: Our prospectively collected database of all 482 patients who underwent partial or radical nephrectomy for a unilateral, unifocal, suspicious renal cortical tumor between January 2001 and October 2005 was reviewed.
  • CONCLUSIONS: This study examined the largest contemporary database evaluating the histologic type of renal lesions according to size.
  • Given the differences in the biological behavior of the various histologic subtypes of these tumors, these data are important when counseling patients about the treated and untreated natural history of small renal masses.

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  • (PMID = 17867935.001).
  • [ISSN] 0892-7790
  • [Journal-full-title] Journal of endourology
  • [ISO-abbreviation] J. Endourol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
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90. Rotman S, Déruaz C, Venetz JP, Chaubert P, Benhattar J, Meuwly JY, Jichlinski P, Guillou L, Moll S, Pascual M, Lemoine R: De novo concurrent papillary renal cell carcinoma and angiomyolipoma in a kidney allograft: evidence of donor origin. Hum Pathol; 2006 Apr;37(4):481-7
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  • [Title] De novo concurrent papillary renal cell carcinoma and angiomyolipoma in a kidney allograft: evidence of donor origin.
  • In the general population, renal cell carcinoma (RCC) is a relatively common neoplasm; however, the papillary RCC subtype is infrequent and represents only 10 to 15% of all RCC.
  • Angiomyolipoma is a well-known common benign tumor.
  • The occurrence of RCC in association with angiomyolipoma is a rare event, with only approximately 50 cases reported in the nontransplantation setting.
  • In transplant recipients, RCC can develop in native kidneys, but its occurrence "de novo" in the renal allograft is very rare with an estimated incidence of less than 0.5%.
  • We report here the case of a 39-year-old woman who underwent cadaveric renal transplantation in 1990.
  • She underwent allograft nephrectomy and the histologic findings revealed that one of the tumors was a chromophilic (type 1) papillary RCC (2.5 cm in diameter) and the other, an angiomyolipoma (1.5 cm).
  • To our knowledge, this is the first report of de novo concurrent papillary RCC and angiomyolipoma in a renal allograft.
  • [MeSH-major] Angiomyolipoma / etiology. Carcinoma, Renal Cell / etiology. Kidney Neoplasms / etiology. Kidney Transplantation / adverse effects. Tissue Donors


91. El-Hashemite N, Walker V, Kwiatkowski DJ: Estrogen enhances whereas tamoxifen retards development of Tsc mouse liver hemangioma: a tumor related to renal angiomyolipoma and pulmonary lymphangioleiomyomatosis. Cancer Res; 2005 Mar 15;65(6):2474-81
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  • [Title] Estrogen enhances whereas tamoxifen retards development of Tsc mouse liver hemangioma: a tumor related to renal angiomyolipoma and pulmonary lymphangioleiomyomatosis.
  • Pulmonary lymphangioleiomyomatosis and abdominal angiomyolipoma are related lesions for which there is no authentic animal model.
  • We found that the Tsc mouse liver hemangioma are composed predominantly of endothelial cells but with a smooth muscle component, and express HMB45 antigen, estrogen receptor, and progesterone receptor, similar to lymphangioleiomyomatosis and angiomyolipoma.
  • These mouse model observations indicate the importance of estrogen signaling in vivo for the growth of tuberous sclerosis lesions, suggesting the possible benefits of tamoxifen therapy for the treatment of angiomyolipoma and lymphangioleiomyomatosis.
  • [MeSH-minor] Angiomyolipoma / genetics. Angiomyolipoma / pathology. Animals. Cystadenoma / genetics. Cystadenoma / pathology. Female. Kidney Neoplasms. Lung Neoplasms / genetics. Lung Neoplasms / pathology. Lymphangioleiomyomatosis / genetics. Lymphangioleiomyomatosis / pathology. Mice. Neovascularization, Pathologic / metabolism. Neovascularization, Pathologic / pathology. Vascular Endothelial Growth Factor A / biosynthesis

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  • (PMID = 15781664.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Grant] United States / NINDS NIH HHS / NS / NS24279; United States / NINDS NIH HHS / NS / NS31535
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Repressor Proteins; 0 / Tumor Suppressor Proteins; 0 / Vascular Endothelial Growth Factor A; 0 / tuberous sclerosis complex 1 protein; 094ZI81Y45 / Tamoxifen; 4JG2LF96VF / tuberous sclerosis complex 2 protein; 4TI98Z838E / Estradiol
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92. Radopoulos D, Tahmatzopoulos A, Kalinderis N, Dimitriadis G: Bilateral synchronous occurrence of three different histological types of renal tumor: a case report. J Med Case Rep; 2009;3:6798
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  • [Title] Bilateral synchronous occurrence of three different histological types of renal tumor: a case report.
  • INTRODUCTION: Renal cell carcinomas account for 85% of all renal neoplasms.
  • With the introduction of modern imaging modalities, there has been an increased diagnosis of renal tumors.
  • Recent studies have shown that partial nephrectomy can be as safe as radical nephrectomy for smaller renal tumors.
  • Renal cell carcinomas are usually unilateral, however, they can be bilateral in 2% to 4% of sporadic cases and considerably more common in familial cases.
  • CASE PRESENTATION: In this case report, we describe an unusual case of two bilateral synchronous chromophobe renal cell carcinomas accompanied by an oncocytoma and an angiomyolipoma, that were all treated by open partial nephrectomy.
  • CONCLUSIONS: To the best of our knowledge, this is the first case report on the synchronous occurrence of bilateral chromophobe renal cell carcinomas associated with an oncocytoma and an angiomyolipoma.

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  • (PMID = 19830124.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2726473
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93. Moudouni SM, Tligui M, Sibony M, Doublet JD, Haab F, Gattegno B, Thibault P: Malignant epithelioid renal angiomyolipoma involving the inferior vena cava in a patient with tuberous sclerosis. Urol Int; 2008;80(1):102-4; discussion 104
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  • [Title] Malignant epithelioid renal angiomyolipoma involving the inferior vena cava in a patient with tuberous sclerosis.
  • Renal angiomyolipomas (AMLs) are mesenchymal tumors that occur either sporadically or are associated with tuberous sclerosis, and are generally considered to be benign.
  • The authors report the case of a patient followed for renal AML.
  • On CT surveillance, this lesion developed features of a malignant tumor involving the renal vein and inferior vena cava.
  • Histological examination demonstrated renal AML with a malignant epithelioid contingent.
  • [MeSH-major] Angiomyolipoma / complications. Epithelium / pathology. Kidney Neoplasms / complications. Tuberous Sclerosis / complications. Vena Cava, Inferior / pathology

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  • [Copyright] (c) 2008 S. Karger AG, Basel.
  • (PMID = 18204243.001).
  • [ISSN] 1423-0399
  • [Journal-full-title] Urologia internationalis
  • [ISO-abbreviation] Urol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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94. Yamagata Y, Kawauchi S, Tamura H, Murakami A, Sasaki K, Sugino N: A case of HMB45-negative perivascular epithelioid cell tumor (PEComa) of the uterine corpus: a possible diagnostic application of molecular-cytogenetic analysis. Eur J Gynaecol Oncol; 2009;30(2):216-9
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  • We report a case of uterine angiomyolipoma confirmed with molecular-genetic analysis by fluorescence in situ hybridization (FISH).
  • FISH examination revealed chromosome X trisomy, which was comparable to a previously reported molecular-genetic finding of PEComa family tumors including angiomyolipoma.
  • Although the tumor was immunohistochemically negative for HMB-45 antigen, the histological and FISH findings were compatible with angiomyolipoma.
  • [MeSH-major] Antigens, Neoplasm / analysis. Biomarkers, Tumor / analysis. Neoplasm Proteins / analysis. Perivascular Epithelioid Cell Neoplasms / diagnosis. Uterine Neoplasms / diagnosis
  • [MeSH-minor] Adult. Angiomyolipoma / diagnosis. Angiomyolipoma / immunology. Angiomyolipoma / pathology. Chromosomes, Human, X / genetics. Cytogenetic Analysis. Female. Humans. In Situ Hybridization, Fluorescence. Melanoma-Specific Antigens. Trisomy

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  • (PMID = 19480261.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins
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95. Cartwright MS, McCarthy SC, Roach ES: Hemimegalencephaly and tuberous sclerosis complex. Neurology; 2005 May 10;64(9):1634
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  • [MeSH-major] Abnormalities, Multiple / diagnosis. Nervous System Malformations / radiography. Telencephalon / abnormalities. Telencephalon / radiography. Tuberous Sclerosis / radiography
  • [MeSH-minor] Angiomyolipoma / diagnosis. Choristoma / radiography. Heart Neoplasms / diagnosis. Humans. Hyperplasia / radiography. Infant, Newborn. Kidney Neoplasms / diagnosis. Magnetic Resonance Imaging. Male. Ossification, Heterotopic / radiography. Rhabdomyoma / diagnosis. Skull / abnormalities. Tomography, X-Ray Computed


96. Faraji H, Nguyen BN, Mai KT: Renal epithelioid angiomyolipoma: a study of six cases and a meta-analytic study. Development of criteria for screening the entity with prognostic significance. Histopathology; 2009 Nov;55(5):525-34
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  • [Title] Renal epithelioid angiomyolipoma: a study of six cases and a meta-analytic study. Development of criteria for screening the entity with prognostic significance.
  • AIMS: Renal epithelioid angiomyolipoma (EAML) is only described in case reports or in multi-institutional small series.
  • In the absence of areas of typical AML, useful features in distinguishing EAML from epithelial renal neoplasms include: extreme degree of cytological atypia, histiocytoid appearance, presence of melanocytic pigments, solid architecture with the absence of frequent areas of alveolar pattern, tubulo-papillary formation and scarring.
  • CONCLUSIONS: Renal neoplasms with certain unusual features should be investigated immunohistochemically to rule out the possibility of EAML.
  • The frequency of adverse outcome is lower in EAML than in renal cell carcinoma.
  • [MeSH-major] Angiomyolipoma / pathology. Epithelioid Cells / pathology. Kidney Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Carcinoma, Renal Cell / pathology. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Middle Aged. Prognosis. Young Adult

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  • (PMID = 19912358.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article; Meta-Analysis
  • [Publication-country] England
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97. Luo DL, Liu YH, Zhuang HG, Luo XL: [Tumors showing perivascular epithelioid cell differentiation: a clinicopathologic study of 39 cases]. Zhonghua Yi Xue Za Zhi; 2007 Nov 6;87(41):2909-13
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  • METHODS: The clinicopathologic data of 39 cases pf angiomyolipoma (AML), 17 males and 22 females, with the primary focus in the kidney on 30 cases, in the liver in 4 cases, in the lung, uterus and broad ligament, abdominal wall, retroperitoneum, and nasal cavity in 1 case respectively, were analyzed.
  • RESULTS: Pathological examination showed branched capillaries or arterioles, often thick-walled similar to those in the renal cell carcinoma, and the cancerous cells consisting of the mixture of epithelial cells and spindle cells.
  • [MeSH-major] Angiomyolipoma / pathology. Epithelioid Cells / pathology. Kidney Neoplasms / pathology

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  • (PMID = 18261305.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Desmin; 0 / S100 Proteins; 0 / Vimentin; 68238-35-7 / Keratins; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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98. Glasgow CG, Steagall WK, Taveira-Dasilva A, Pacheco-Rodriguez G, Cai X, El-Chemaly S, Moses M, Darling T, Moss J: Lymphangioleiomyomatosis (LAM): molecular insights lead to targeted therapies. Respir Med; 2010 Jul;104 Suppl 1:S45-58
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  • LAM is a rare lung disease, found primarily in women of childbearing age, characterized by cystic lung destruction and abdominal tumors (e.g., renal angiomyolipoma, lymphangioleiomyoma).

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  • [Copyright] Copyright (c) 2010. Published by Elsevier Ltd.
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  • (PMID = 20630348.001).
  • [ISSN] 1532-3064
  • [Journal-full-title] Respiratory medicine
  • [ISO-abbreviation] Respir Med
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z01 HL002541-12; United States / Intramural NIH HHS / / Z01 HL002541-13; United States / Intramural NIH HHS / / ZIA HL002541-14
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p21; 0 / Tumor Suppressor Proteins; 0 / tuberous sclerosis complex 1 protein; 4JG2LF96VF / tuberous sclerosis complex 2 protein; EC 2.7.1.1 / TOR Serine-Threonine Kinases
  • [Other-IDs] NLM/ NIHMS206406; NLM/ PMC3030250
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99. Tamai H, Takiguchi Y, Oka M, Shingaki N, Enomoto S, Shiraki T, Furuta M, Inoue I, Iguchi M, Yanaoka K, Arii K, Shimizu Y, Nakata H, Shinka T, Sanke T, Ichinose M: Contrast-enhanced ultrasonography in the diagnosis of solid renal tumors. J Ultrasound Med; 2005 Dec;24(12):1635-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Contrast-enhanced ultrasonography in the diagnosis of solid renal tumors.
  • OBJECTIVE: The purpose of this study was to evaluate the usefulness of contrast-enhanced ultrasonography (CEUS) in the diagnosis of solid renal tumors.
  • METHODS: Twenty-nine patients with solid tumors detected on gray scale ultrasonography underwent resection for suspected renal malignancy.
  • Findings of arterial phase contrast computed tomography (CT) and CEUS were compared for each diagnosis.
  • RESULTS: Histopathologic examination of resected lesions showed malignancy in 26 patients (clear cell carcinoma, n = 18; papillary renal cell carcinoma, n = 6; collecting duct carcinoma, n = 1; and infiltrative urothelial carcinoma, n = 1) and benign tumors in 3 patients (oncocytoma, n = 2; and angiomyolipoma, n = 1).
  • Positive predictive values of CEUS and contrast CT in the diagnosis of renal malignancy were 100% and 82.8%, respectively.
  • However, CEUS showed blood flow in these lesions, leading to diagnosis of hypovascular renal tumors.
  • CONCLUSIONS: Contrast-enhanced ultrasonography was more sensitive for detecting slight tumor blood flow than contrast CT and was useful in preoperatively diagnosing malignant hypovascular renal tumors but was less so for hypervascular renal tumors.
  • [MeSH-major] Contrast Media. Image Enhancement / methods. Kidney Neoplasms / radiography. Kidney Neoplasms / ultrasonography. Neovascularization, Pathologic / radiography. Neovascularization, Pathologic / ultrasonography. Ultrasonography / methods

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  • (PMID = 16301719.001).
  • [ISSN] 0278-4297
  • [Journal-full-title] Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
  • [ISO-abbreviation] J Ultrasound Med
  • [Language] eng
  • [Publication-type] Controlled Clinical Trial; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
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100. Bierer S, Wülfing C, Bode ME, Pühse G, Brinkmann OA, Hertle L: [Bilateral renal angiomyolipomas with a thrombus in the inferior caval vein. Rare growth pattern of a benign tumor]. Urologe A; 2005 Dec;44(12):1469-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Bilateral renal angiomyolipomas with a thrombus in the inferior caval vein. Rare growth pattern of a benign tumor].
  • Renal angiomyolipomas are mesenchymal tumors that are composed of fat tissue, smooth muscle cells and vessels.
  • We report a new case of bilateral renal angiomyolipomas with a caval thrombus in a 36 year old female patient with tuberous sclerosis, and give a brief review of the related literature.
  • [MeSH-major] Angiomyolipoma / complications. Angiomyolipoma / diagnosis. Kidney Neoplasms / complications. Kidney Neoplasms / diagnosis. Vena Cava, Inferior / pathology. Venous Thrombosis / diagnosis. Venous Thrombosis / etiology

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  • (PMID = 16133230.001).
  • [ISSN] 0340-2592
  • [Journal-full-title] Der Urologe. Ausg. A
  • [ISO-abbreviation] Urologe A
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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