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1. Matsuyama A, Hisaoka M, Ichikawa K, Fujimori T, Udo K, Uchihashi K, Aoki S, Hashimoto H: Sclerosing variant of epithelioid angiomyolipoma. Pathol Int; 2008 May;58(5):306-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sclerosing variant of epithelioid angiomyolipoma.
  • Presented herein are two unusual epithelioid angiomyolipomas (AML) displaying prominent stromal sclerosis.
  • One patient (case 1) had a 2 cm lesion arising in the renal cortex, and another (case 2) had a pararenal retroperitoneal tumor measuring 13 cm.
  • [MeSH-major] Angiomyolipoma / pathology. Epithelioid Cells / pathology. Kidney Neoplasms / pathology. Retroperitoneal Neoplasms / pathology

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  • (PMID = 18429830.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / MART-1 Antigen; 0 / MLANA protein, human; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins
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2. Davis C, Boyett T, Caridi J: Renal artery embolization: application and success in patients with renal cell carcinoma and angiomyolipoma. Semin Intervent Radiol; 2007 Mar;24(1):111-6
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  • [Title] Renal artery embolization: application and success in patients with renal cell carcinoma and angiomyolipoma.
  • Renal artery embolization is a procedure primarily performed by interventional radiologists that can be utilized for treatment of renal tumors, both malignant and benign.
  • It has many applications, including pretreatment of renal cell carcinomas prior to planned resection to decrease hemorrhagic complications intraoperatively, treatment of malignant renal tumor in patients who are not deemed suitable surgical candidates, as well as treatment of benign renal tumors and their potential hemorrhagic complications.
  • We describe how the procedure is approached at the University of Florida-Gainesville and provide examples of two cases, a renal cell carcinoma and an angiomyolipoma, treated at our institution with transcatheter embolotherapy.

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  • (PMID = 21326748.001).
  • [ISSN] 0739-9529
  • [Journal-full-title] Seminars in interventional radiology
  • [ISO-abbreviation] Semin Intervent Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3036337
  • [Keywords] NOTNLM ; Renal artery embolization / angiomyolipoma / renal cell carcinoma
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3. Richmond L, Atri M, Sherman C, Sharir S: Renal cell carcinoma containing macroscopic fat on CT mimics an angiomyolipoma due to bone metaplasia without macroscopic calcification. Br J Radiol; 2010 Aug;83(992):e179-81
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  • [Title] Renal cell carcinoma containing macroscopic fat on CT mimics an angiomyolipoma due to bone metaplasia without macroscopic calcification.
  • We report a case of renal cell carcinoma (RCC) containing foci of macroscopic fat, which were pathologically proven to be areas of osseous metaplasia.
  • The finding is significant because standard imaging practice is to classify a renal mass containing intratumoral macroscopic fat that is not associated with calcification, ossification or invasion of perirenal or hilar fat as an angiomyolipoma.
  • [MeSH-major] Angiomyolipoma / radiography. Bone and Bones / pathology. Carcinoma, Renal Cell / radiography. Kidney Neoplasms / radiography. Neoplasms, Adipose Tissue / pathology
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Metaplasia / pathology. Metaplasia / radiography. Middle Aged. Tomography, X-Ray Computed / methods

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  • (PMID = 20647509.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3473503
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4. Hadley DA, Bryant LJ, Ruckle HC: Conservative treatment of renal angiomyolipomas in patients with tuberous sclerosis. Clin Nephrol; 2006 Jan;65(1):22-7
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  • [Title] Conservative treatment of renal angiomyolipomas in patients with tuberous sclerosis.
  • AIMS: Renal angiomyolipoma (AML) associated with tuberous sclerosis (TS) presents a treatment dilemma due to multifocal tumors with a potential for significant growth and subsequent hemorrhage.
  • MATERIALS AND METHODS: We reviewed 8 patients (16 renal units) with bilateral renal AMLs and comorbid TS.
  • We evaluated their renal function, renal imaging, and clinical course.
  • The mean serum creatinine of these patients at the time of diagnosis was 0.75 mg/dl (range 0.4 - 1.1).
  • Of the 8 patients, 6 received treatment during the course of their disease, including arterial embolization of 7 renal units in 5 symptomatic patients (2 patients needed 2 embolizations).
  • Partial nephrectomy was performed on 2 renal units in 2 patients, and a total nephrectomy was performed in 1971 on another patient.
  • Currently, all 8 patients have stable renal function; 4 patients are asymptomatic with regards to their lesions, while the other 4 patients report transient flank pain adequately controlled with oral analgesics (2 patients with propoxyphene plus acetaminophen 100/650 mg PO t.i.d. p.r.n., the other 2 patients with ibuprofen 600 mg PO p.r.n.).
  • CONCLUSIONS: Our study and a review of the literature have not revealed an obvious or quantitative risk of morbidity or mortality from renal hemorrhage directly related to AMLs of any specific size in TS patients.
  • [MeSH-major] Angiomyolipoma / therapy. Kidney Neoplasms / therapy. Tuberous Sclerosis / complications

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  • (PMID = 16429838.001).
  • [ISSN] 0301-0430
  • [Journal-full-title] Clinical nephrology
  • [ISO-abbreviation] Clin. Nephrol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Analgesics; AYI8EX34EU / Creatinine
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5. Ghervan L, Lucan V, Elec F, Suciu M, Bologa F, Iacob G, Lucan M: Retro-peritoneoscopic assisted cryoablation for small renal tumors: the first cases treated in Romania. Chirurgia (Bucur); 2007 Sep-Oct;102(5):557-62
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  • [Title] Retro-peritoneoscopic assisted cryoablation for small renal tumors: the first cases treated in Romania.
  • Retro-peritoneoscopic cryoablation (RCA), combine the benefits of minimal invasiveness of the laparoscopy with the advantage of preserving renal function of the nephron sparing surgery.
  • The aim of our study was to assess the initial results with RCA of small renal tumors.
  • Since Jan 2007, twelve consecutive patients, with small renal tumors (mean tumor size 3.89 cm) underwent RCA at our institution.
  • Histological examination of the core biopsy revealed clear cell carcinoma in 8 patients, papillary carcinoma in 3 patients and angiomyolipoma in 1 patient.
  • Cryosurgical ablation of small renal tumors using multiple ultrathin 17 Gauge cryoprobes is a feasible treatment option.
  • Retro-peritoneoscopic approach allows optimal access to the kidney and endoscopic real-time ultrasound control of the freezing process.
  • [MeSH-major] Cryosurgery. Kidney Neoplasms / surgery

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  • (PMID = 18018356.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
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6. Takasu N, Hayashi M, Takara M, Iha T, Kouki T, Ohshiro Y, Ogawa Y: False-positive 123I-metaiodobenzylguanidine (MIBG) scan in a patient with angiomyolipoma; positive MIBG scan does not necessarily indicate the presence of pheochromocytoma. Intern Med; 2007;46(20):1717-21
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  • [Title] False-positive 123I-metaiodobenzylguanidine (MIBG) scan in a patient with angiomyolipoma; positive MIBG scan does not necessarily indicate the presence of pheochromocytoma.
  • 123I-Metaiodobenzylguanidine (123I-MIBG)-accumulation in angiomyolipoma (AML) is demonstrated.
  • 123I-MIBG-accumulation in AML led to a false-positive diagnosis of adrenal pheochromocytoma.
  • [MeSH-major] 3-Iodobenzylguanidine. Adrenal Gland Neoplasms / radionuclide imaging. Angiomyolipoma / radionuclide imaging. Pheochromocytoma / radionuclide imaging. Radiopharmaceuticals
  • [MeSH-minor] Adult. Diagnosis, Differential. False Positive Reactions. Female. Humans. Magnetic Resonance Angiography. Tomography, Emission-Computed, Single-Photon

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  • (PMID = 17938527.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 35MRW7B4AD / 3-Iodobenzylguanidine
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7. Somani BK, Nabi G, Thorpe P, Hussey J, McClinton S: Therapeutic transarterial embolisation in the management of benign and malignant renal conditions. Surgeon; 2006 Dec;4(6):348-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Therapeutic transarterial embolisation in the management of benign and malignant renal conditions.
  • PURPOSE: The aim of this study was to critically appraise the efficacy and complications of Therapeutic Transarterial Embolisation (TAE) in various benign and malignant renal conditions.
  • MATERIAL AND METHODS: The records of all patients who underwent renal embolisation procedures, at a single institution, between March 1992 and March 2004, were reviewed.
  • In the haematuria group, selective embolisation was used to treat bleeding post percutaneous nephrolithotomy (PCNL) (n=4), angiomyolipoma (n=2), arteriovenous (AV) malformation (n=l1), renal artery aneurysm (n=1) and renal trauma (n=2).
  • In the renal pain group (n=3), non-selective embolisation was done.
  • Fifteen patients with advanced renal malignancy, who were deemed unfit for surgery, underwent 18 embolisation procedures for symptomatic haematuria.
  • CONCLUSION: Renal artery embolisation is effective in managing haematuria in benign and malignant renal conditions where indicated, with minor and easily treatable adverse effects
  • [MeSH-major] Embolization, Therapeutic. Kidney Diseases / therapy. Renal Artery / surgery
  • [MeSH-minor] Adult. Aged. Aneurysm / therapy. Angiomyolipoma / therapy. Arteriovenous Fistula / therapy. Female. Follow-Up Studies. Hematuria / therapy. Humans. Hydronephrosis / therapy. Kidney Neoplasms / therapy. Male. Middle Aged. Renal Veins / abnormalities. Renal Veins / surgery. Retrospective Studies. Treatment Outcome

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  • (PMID = 17152199.001).
  • [ISSN] 1479-666X
  • [Journal-full-title] The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
  • [ISO-abbreviation] Surgeon
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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8. Godara R, Vashist MG, Singla SL, Garg P, Sen J, Mathur SK, Gupta A: Adrenal angiomyolipoma: A rare entity. Indian J Urol; 2007 Jul;23(3):319-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adrenal angiomyolipoma: A rare entity.
  • Angiomyolipoma is apparently a part of a family of neoplasms that derive from perivascular epitheloid cells.
  • It is a rare mesenchymal tumor, usually found in the kidney.
  • Extrarenal angiomyolipoma is uncommon and the most common extrarenal site is the liver.
  • Only two cases of adrenal angiomyolipoma are reported in English literature.

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  • [Cites] J Am Acad Dermatol. 2006 Jan;54(1):167-71 [16384779.001]
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  • (PMID = 19718340.001).
  • [ISSN] 0970-1591
  • [Journal-full-title] Indian journal of urology : IJU : journal of the Urological Society of India
  • [ISO-abbreviation] Indian J Urol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2721616
  • [Keywords] NOTNLM ; Adrenal / angiomyolipoma / extrarenal
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9. Herry I, Neukirch C, Debray MP, Mignon F, Crestani B: Dramatic effect of sirolimus on renal angiomyolipomas in a patient with tuberous sclerosis complex. Eur J Intern Med; 2007 Jan;18(1):76-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dramatic effect of sirolimus on renal angiomyolipomas in a patient with tuberous sclerosis complex.
  • Angiomyolipomas are very common in patients with tuberous sclerosis complex (TSC) and cause substantial morbidity.
  • We report the case of a woman with TSC and giant angiolipomas in whom sirolimus induced a dramatic reduction in bilateral renal tumors.

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  • (PMID = 17223050.001).
  • [ISSN] 0953-6205
  • [Journal-full-title] European journal of internal medicine
  • [ISO-abbreviation] Eur. J. Intern. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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10. Ishibashi N, Mochizuki T, Tanaka H, Okada Y, Kobayashi M, Takahashi M: A case of lipiduria after arterial embolization for renal angiomyolipomas. Cardiovasc Intervent Radiol; 2010 Jun;33(3):615-8
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  • [Title] A case of lipiduria after arterial embolization for renal angiomyolipomas.
  • We report the case of a 31-year-old woman who suffered lipiduria after selective transcatheter arterial embolization for renal angiomyolipoma (AML).
  • [MeSH-major] Angiomyolipoma / therapy. Embolization, Therapeutic / methods. Kidney Neoplasms / therapy. Lipids / urine

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  • (PMID = 20087737.001).
  • [ISSN] 1432-086X
  • [Journal-full-title] Cardiovascular and interventional radiology
  • [ISO-abbreviation] Cardiovasc Intervent Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Lipids
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11. Clements D, Markwick LJ, Puri N, Johnson SR: Role of the CXCR4/CXCL12 axis in lymphangioleiomyomatosis and angiomyolipoma. J Immunol; 2010 Aug 1;185(3):1812-21
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  • [Title] Role of the CXCR4/CXCL12 axis in lymphangioleiomyomatosis and angiomyolipoma.
  • Lymphangioleiomyomatosis (LAM) is a progressive disease caused by accumulation of metastatic (LAM) cells in the lungs, lymphatics, and the tumor angiomyolipoma (AML).
  • [MeSH-major] Angiomyolipoma / immunology. Angiomyolipoma / pathology. Chemokine CXCL12 / physiology. Lymphangioleiomyomatosis / immunology. Lymphangioleiomyomatosis / pathology. Receptors, CXCR4 / physiology

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  • (PMID = 20585037.001).
  • [ISSN] 1550-6606
  • [Journal-full-title] Journal of immunology (Baltimore, Md. : 1950)
  • [ISO-abbreviation] J. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Apoptosis Regulatory Proteins; 0 / CXCL12 protein, human; 0 / CXCR4 protein, human; 0 / Chemokine CXCL12; 0 / Inflammation Mediators; 0 / Receptors, CXCR4; 0 / Tumor Suppressor Proteins; 0 / tuberous sclerosis complex 1 protein
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12. Chilosi M, Pea M, Martignoni G, Brunelli M, Gobbo S, Poletti V, Bonetti F: Cathepsin-k expression in pulmonary lymphangioleiomyomatosis. Mod Pathol; 2009 Feb;22(2):161-6
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  • Lymphangioleiomyomatosis is a rare and progressive lung cystic disease, caused by the infiltration of lung parenchyma by mesenchymal cells characterized by co-expression of contractile proteins and melanocytic markers.
  • Twelve angiomyolipomas and several lung diseases (sarcoidosis, organizing pneumonia, usual interstitial pneumonia, emphysema) were investigated as controls.
  • Similar expression levels were observed in renal angiomyolipomas.
  • These observations extend the knowledge regarding the immunophenotypic profile of lymphangioleiomyomatosis cells, and provide a useful new marker for diagnosis in difficult cases (eg, in small transbronchial biopsies).
  • The strong expression of such a potent papain-like cysteine protease in lymphangioleiomyomatosis cells can significantly contribute to the progressive remodelling of lung parenchyma observed in this deadly disease, with eventual formation of lung cysts.
  • [MeSH-minor] Angiomyolipoma / enzymology. Case-Control Studies. Cathepsin K. Humans. Immunohistochemistry. Kidney Neoplasms / enzymology

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  • (PMID = 19060845.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 3.4.- / Cathepsins; EC 3.4.22.38 / CTSK protein, human; EC 3.4.22.38 / Cathepsin K
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13. Miniati D, Gay AN, Parks KV, Naik-Mathuria BJ, Hicks J, Nuchtern JG, Cass DL, Olutoye OO: Imaging accuracy and incidence of Wilms' and non-Wilms' renal tumors in children. J Pediatr Surg; 2008 Jul;43(7):1301-7
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  • [Title] Imaging accuracy and incidence of Wilms' and non-Wilms' renal tumors in children.
  • PURPOSE: The purpose of this study is to determine the actual incidence, age distribution, and preoperative imaging accuracy of non-Wilms' tumors (nWT) in children with renal masses.
  • METHODS: Pathologic reports from all tumor nephrectomies or open renal biopsies performed at a single institution from September 1999 to June 2005 were analyzed.
  • The nWT group included congenital mesoblastic nephroma (5), clear cell sarcoma (4), neuroblastoma (4), renal cell carcinoma (4), lymphoma (2), angiomyolipoma (2), teratoma (1), hemangioma (1), and renal epithelial tumor (1).
  • Sensitivity, specificity, positive predictive value, and negative predictive value for computed tomography (CT) determining a diagnosis of WT were 0.92, 0.55, 0.84, and 0.73, respectively.
  • The CT reports explicitly stated a potential diagnosis in 89% of cases, with a diagnostic accuracy of 82%.
  • CONCLUSIONS: Non-Wilms' tumors may represent a significant proportion of renal tumors in children, especially in children aged less than 6 months or greater than 12 years.
  • These data have significant implications for parental counseling, surgical plan, and the choice of neoadjuvant chemotherapy and argue in favor of obtaining a tissue diagnosis before instituting therapy.
  • [MeSH-major] Kidney / pathology. Kidney Neoplasms / diagnosis. Wilms Tumor / diagnosis

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  • (PMID = 18639686.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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14. Compérat EV, Vasiliu V, Ferlicot S, Camparo P, Sibony M, Vieillefond A: [Tumors of the kidneys: new entities]. Ann Pathol; 2005 Apr;25(2):117-33
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  • [Title] [Tumors of the kidneys: new entities].
  • Since 1998 new entities have surfaced in renal tumor classification and have been included in the WHO 2004 classification.
  • In this article, we will discuss the following entities: multilocular clear cell renal carcinoma, Xp11 translocation carcinoma, low grade mucinous tubular carcinoma, epithelioid angiomyolipoma, benign mixed epithelial and stromal tumor.
  • We will investigate new concepts of hybrid oncocytoma and chromophobe renal cell carcinoma and the syndrome of Birt-Hogg-Dube which is associated to kidney tumors.
  • [MeSH-major] Kidney Neoplasms / classification. Kidney Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma, Clear Cell / pathology. Angiomyolipoma / pathology. Carcinoma / genetics. Carcinoma / pathology. Humans. Translocation, Genetic

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  • (PMID = 16142163.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 77
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15. Rosenkrantz AB, Hecht EM, Taneja SS, Melamed J: Angiomyolipoma with epithelial cysts: mimic of renal cell carcinoma. Clin Imaging; 2010 Jan-Feb;34(1):65-8
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  • [Title] Angiomyolipoma with epithelial cysts: mimic of renal cell carcinoma.
  • Angiomyolipoma with epithelial cysts (AMLEC) is a rare variant of angiomyolipoma with minimal fat that contains epithelial-lined cysts and may mimic a cystic renal cell carcinoma.
  • [MeSH-major] Angiomyolipoma / complications. Angiomyolipoma / diagnosis. Kidney Diseases, Cystic / complications. Kidney Diseases, Cystic / diagnosis. Kidney Neoplasms / complications. Kidney Neoplasms / diagnosis. Magnetic Resonance Imaging. Tomography, X-Ray Computed
  • [MeSH-minor] Adult. Carcinoma, Renal Cell / complications. Carcinoma, Renal Cell / diagnosis. Diagnosis, Differential. Female. Humans. Incidental Findings


16. Majid S, White D, Sarkar S: An unusual cause for the incidental finding of multiple liver lesions. Diagnosis: multiple fatty vascular lesions of angiomyolipomas. Gut; 2006 Jul;55(7):983, 1029
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  • [Title] An unusual cause for the incidental finding of multiple liver lesions. Diagnosis: multiple fatty vascular lesions of angiomyolipomas.
  • [MeSH-major] Angiomyolipoma / radiography. Fatty Liver / radiography. Liver / radiography. Liver Neoplasms / radiography

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  • (PMID = 16766752.001).
  • [ISSN] 0017-5749
  • [Journal-full-title] Gut
  • [ISO-abbreviation] Gut
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1856355
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17. Baccala A, Sercia L, Li J, Heston W, Zhou M: Expression of prostate-specific membrane antigen in tumor-associated neovasculature of renal neoplasms. Urology; 2007 Aug;70(2):385-90
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  • [Title] Expression of prostate-specific membrane antigen in tumor-associated neovasculature of renal neoplasms.
  • Recently, PSMA has been found in the neovasculature in association with other solid malignant tumors, including clear cell renal carcinoma (RCC).
  • We studied the expression of PSMA in different primary renal tumors.
  • METHODS: A tissue microarray was constructed from 60 normal kidney, 21 clear cell RCC (CCRCC), 20 papillary RCC (PRCC), 16 chromophobe RCC, 19 oncocytoma, 14 transitional cell carcinoma, and 19 angiomyolipoma (AML) specimens.
  • RESULTS: PSMA was expressed in the proximal tubules of the normal kidney and in the tumor-associated vasculature in the renal tumors.
  • CONCLUSIONS: PSMA is differentially expressed in the tumor-associated neovasculature in different renal tumors.
  • This finding suggests that antibodies against PSMA may potentially be used as a diagnostic marker and therapeutic target for renal neoplasms.
  • [MeSH-major] Antigens, Surface / biosynthesis. Carcinoma, Renal Cell / blood supply. Carcinoma, Renal Cell / immunology. Glutamate Carboxypeptidase II / biosynthesis. Kidney Neoplasms / blood supply. Kidney Neoplasms / immunology

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  • (PMID = 17826525.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Surface; EC 3.4.17.21 / Glutamate Carboxypeptidase II; EC 3.4.17.21 / glutamate carboxypeptidase II, human
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18. Tokuyama Y, Fujita T, Hirayama T, Shirai M, Kazama A, Iwamura M, Baba S: [Epithelioid angiomyolipoma of the kidney]. Hinyokika Kiyo; 2010 Feb;56(2):103-6
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  • [Title] [Epithelioid angiomyolipoma of the kidney].
  • A 50-year-old male was referred to our hospital for a left renal mass which was incidentally found during a medical check-up.
  • Abdominal ultrasonography, computed tomography, and magnetic resonance imaging showed a weak enhancement tumor devoid of fat densities at the lower pole of the left kidney.
  • Under the diagnosis of renal cell carcinoma, radical nephrectomy was performed.
  • The patient was diagnosed with epithelioid angiomyolipoma of the kidney.
  • Epithelioid angiomyolipoma is a rare variant of angiomyolipoma, which is sometimes occurred aggressive clinical behavior.
  • [MeSH-major] Angiomyolipoma / diagnosis
  • [MeSH-minor] Carcinoma, Renal Cell / diagnosis. Diagnosis, Differential. Humans. Kidney Neoplasms / pathology. Male. Middle Aged

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  • (PMID = 20185996.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 19
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19. Carelli S, Lesma E, Paratore S, Grande V, Zadra G, Bosari S, Di Giulio AM, Gorio A: Survivin expression in tuberous sclerosis complex cells. Mol Med; 2007 Mar-Apr;13(3-4):166-77
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  • Tuberous Sclerosis Complex (TSC) is a tumor suppressor gene disorder with mutations of TSC1/TSC2 genes.
  • This leads to the development of hamartomas that most frequently affect central nervous system, kidney, and skin.
  • Angiomyolipomas are abdominal masses made up of muscle vessels and adipose tissues that grow mostly in proximity to kidneys and liver.
  • Bleeding and kidney failure are the major justification for surgery.
  • This study shows that angiomyolipoma-derived human smooth muscle TSC2-/- cells express the apoptosis inhibitor protein survivin when exposed to IGF-1.
  • These cells release IGF-1 by means of a negative feedback-regulated mechanism that is overrun when they are exposed to antibodies to IGF-1R, which increases the released amount by more than 400%.
  • The autocrine release of IGF-1 may therefore be a powerful mechanism of survival of the tightly packed cells in the thick-walled vessels of TSC angiomyolipoma and in lymphangioleiomyomatosis (LAM) nodules.
  • [MeSH-major] Angiomyolipoma / pathology. Gene Expression. Inhibitor of Apoptosis Proteins / metabolism. Tuberous Sclerosis / pathology. Tumor Suppressor Proteins / metabolism


20. Armah HB, Parwani AV: Perivascular epithelioid cell tumor. Arch Pathol Lab Med; 2009 Apr;133(4):648-54
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  • This tumor family shows marked female predominance and includes angiomyolipoma, clear cell sugar tumor, lymphangioleiomyomatosis, and a group of rare, morphologically and immunophenotypically similar tumors arising at a variety of visceral and soft tissue sites.

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  • (PMID = 19391667.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 30
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21. Wahab S, Ahmad Khan R, Thapa M, Wahab A, Ahmad I: Giant angiomyolipoma associated with a dilated vessel prone to hemorrhage. Iran J Kidney Dis; 2009 Jul;3(3):168-71
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  • [Title] Giant angiomyolipoma associated with a dilated vessel prone to hemorrhage.
  • Angiomyolipomas are benign neoplasms of the kidney which can clinically mimic renal malignancy.
  • The imaging features are quite characteristic, and diagnosis can be clinched solely based on radiological investigations.
  • We report a case of giant angiomyolipoma with a dilated vessel susceptible to hemorrhage.
  • [MeSH-major] Angiomyolipoma / complications. Hemorrhage / etiology. Kidney Neoplasms / complications. Severity of Illness Index
  • [MeSH-minor] Female. Humans. Kidney Cortex / pathology. Kidney Cortex / radiography. Magnetic Resonance Imaging. Middle Aged. Tomography, X-Ray Computed. Vasodilation

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  • (PMID = 19617667.001).
  • [ISSN] 1735-8582
  • [Journal-full-title] Iranian journal of kidney diseases
  • [ISO-abbreviation] Iran J Kidney Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Iran
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22. Schuetz AN, Yin-Goen Q, Amin MB, Moreno CS, Cohen C, Hornsby CD, Yang WL, Petros JA, Issa MM, Pattaras JG, Ogan K, Marshall FF, Young AN: Molecular classification of renal tumors by gene expression profiling. J Mol Diagn; 2005 May;7(2):206-18
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  • [Title] Molecular classification of renal tumors by gene expression profiling.
  • Renal tumor classification is important because histopathological subtypes are associated with distinct clinical behavior.
  • However, diagnosis is difficult because tumor subtypes have overlapping microscopic characteristics.
  • We used oligonucleotide microarrays to analyze 31 adult renal tumors, including clear cell renal cell carcinoma (RCC), papillary RCC, chromophobe RCC, oncocytoma, and angiomyolipoma.
  • Clear cell RCC overexpressed proximal nephron, angiogenic, and immune response genes, chromophobe RCC oncocytoma overexpressed distal nephron and oxidative phosphorylation genes, papillary RCC overexpressed serine protease inhibitors, and extracellular matrix products, and angiomyolipoma overexpressed muscle developmental, lipid biosynthetic, melanocytic, and distinct angiogenic factors.
  • Quantitative reverse transcriptase-polymerase chain reaction and immunohistochemistry of formalin-fixed renal tumors confirmed overexpression of proximal nephron markers (megalin/low-density lipoprotein-related protein 2, alpha-methylacyl CoA racemase) in clear cell and papillary RCC and distal nephron markers (beta-defensin 1, claudin 7) in chromophobe RCC/oncocytoma.
  • In summary, renal tumor subtypes were classified by distinct gene expression profiles, illustrating tumor pathobiology and translating into novel molecular bioassays using fixed tissue.
  • [MeSH-major] Gene Expression Profiling. Kidney Neoplasms / classification. Oligonucleotide Array Sequence Analysis

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  • (PMID = 15858144.001).
  • [ISSN] 1525-1578
  • [Journal-full-title] The Journal of molecular diagnostics : JMD
  • [ISO-abbreviation] J Mol Diagn
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1867531
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23. Loffroy R, Rao P, Kwak BK, Ota S, De Lin M, Liapi E, Geschwind JF: Transcatheter arterial embolization in patients with kidney diseases: an overview of the technical aspects and clinical indications. Korean J Radiol; 2010 May-Jun;11(3):257-68
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  • [Title] Transcatheter arterial embolization in patients with kidney diseases: an overview of the technical aspects and clinical indications.
  • There are a number of indications for this approach in urological practice, in particular for the patients with parenchymatous or vascular kidney disease.
  • [MeSH-major] Adenocarcinoma / therapy. Angiomyolipoma / therapy. Embolization, Therapeutic / methods. Kidney Diseases / therapy. Kidney Neoplasms / therapy
  • [MeSH-minor] Aneurysm / therapy. Humans. Kidney / injuries

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  • (PMID = 20461179.001).
  • [ISSN] 2005-8330
  • [Journal-full-title] Korean journal of radiology
  • [ISO-abbreviation] Korean J Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Korea (South)
  • [Number-of-references] 35
  • [Other-IDs] NLM/ PMC2864852
  • [Keywords] NOTNLM ; Arterial embolization / Interventional radiology / Kidney / Surgery
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24. Marino G, Pedalino M, Di Primio OG, Piras D, Vella R, Verces E, Carbonatto P: [Wunderlich syndrome. Clinical and therapeutic aspects of a long-term experience]. Urologia; 2010 Jul-Sep;77(3):193-7
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  • [Title] [Wunderlich syndrome. Clinical and therapeutic aspects of a long-term experience].
  • INTRODUCTION: Wunderlich's syndrome is defined as a clinical manifestation secondary to sudden spontaneous rupture of renal parenchyma in the absence of injury, resulting in hemoretroperitoneum.
  • This syndrome may occur in patients with benign or malignant neoplasm of the kidney, arterial venous fistulae, immunovasculitis and other phlogosis of the kidney.
  • MATERIALS AND METHODS: We present 19 cases of acute spontaneous hemoretroperitoneum or Wunderlich's syndrome diagnosed from 1996 to 2009, related to the following conditions: 7 renal carcinomas, 4 angiomyolipomas, 2 adrenal hemorrhages, 1 bleeding polycystic kidney, 2 hemorrhagic renal cysts and three cases of immunovasculitis.
  • Overall, 6 patients were treated with acetylsalicylic acid and 4 with dicumarolics for cardiovascular disease, while 13 patients were suffering from hypertension?
  • CONCLUSIONS: The spontaneous hemoretroperitoneum is a rare syndrome associated with acute kidney disease often unknown to the patient and only in selected cases with small hematoma; it is possible to perform arteriography with selective embolization of branches avoiding renal access surgery.
  • [MeSH-major] Hemoperitoneum / diagnosis. Hemoperitoneum / therapy. Kidney Diseases / diagnosis. Kidney Diseases / therapy
  • [MeSH-minor] Acute Disease. Humans. Retroperitoneal Space. Rupture, Spontaneous. Syndrome. Time Factors

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  • (PMID = 20931549.001).
  • [ISSN] 1724-6075
  • [Journal-full-title] Urologia
  • [ISO-abbreviation] Urologia
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] United States
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25. Blick C, Ravindranath N, Muneer A, Jones A: Bilateral renal angiomyolipomas with invasion of the renal vein: a case report. ScientificWorldJournal; 2008;8:145-8
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  • [Title] Bilateral renal angiomyolipomas with invasion of the renal vein: a case report.
  • An angiomyolipoma (AML) is usually a benign, rare, and, more commonly, a unilateral renal tumour.
  • [MeSH-major] Angiomyolipoma / pathology. Kidney Neoplasms / pathology. Renal Veins / pathology

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  • (PMID = 18264631.001).
  • [ISSN] 1537-744X
  • [Journal-full-title] TheScientificWorldJournal
  • [ISO-abbreviation] ScientificWorldJournal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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26. Krischock L, Beach R, Taylor J: Sirolimus and tuberous sclerosis-associated renal angiomyolipomas. Arch Dis Child; 2010 May;95(5):391-2
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  • [Title] Sirolimus and tuberous sclerosis-associated renal angiomyolipomas.
  • Tuberous sclerosis, caused by germline mutations in the TSC1 or TSC2 genes, is associated with aberrant upregulation of the mammalian target of rapamycin (mTOR) signalling pathway, resulting in growth of tumours, including renal angiomyolipomas (AMLs).
  • AMLs may cause hypertension, renal failure and spontaneous life-threatening haemorrhage.
  • We present here the case of a paediatric patient with TSC in whom sirolimus has been used successfully to halt growth of renal AMLs.
  • [MeSH-major] Angiomyolipoma / drug therapy. Antibiotics, Antineoplastic / therapeutic use. Kidney Neoplasms / drug therapy. Sirolimus / therapeutic use. Tuberous Sclerosis / complications


27. Bogue CO, Hodnett P, Doyle DJ, Plant WD, Barry JE, Maher MM: Answer to case of the month #137. Giant pseudoaneurysm complicating an angiomyolipoma in a patient with tuberous sclerosis. Can Assoc Radiol J; 2008 Oct;59(4):213-6
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  • [Title] Answer to case of the month #137. Giant pseudoaneurysm complicating an angiomyolipoma in a patient with tuberous sclerosis.
  • [MeSH-major] Aneurysm, False / diagnosis. Angiomyolipoma / complications. Kidney Neoplasms / complications. Tuberous Sclerosis / complications
  • [MeSH-minor] Abdomen / ultrasonography. Adult. Anemia / etiology. Angiography. Contrast Media. Diagnosis, Differential. Embolization, Therapeutic / methods. Female. Flank Pain / etiology. Hematuria / etiology. Humans. Pelvis / radiography. Radiographic Image Enhancement / methods. Radiography, Abdominal / methods. Tomography, X-Ray Computed / methods. Treatment Outcome

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  • (PMID = 19069607.001).
  • [ISSN] 0846-5371
  • [Journal-full-title] Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes
  • [ISO-abbreviation] Can Assoc Radiol J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
  • [Chemical-registry-number] 0 / Contrast Media
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28. Kida Y, Yamaguchi K, Suzuki H, Kanda E, Ando M, Ohashi K, Funata N, Saito H: Tuberous sclerosis, associated with renal cell carcinoma and angiomyolipoma, in a patient who developed endstage renal failure after nephrectomy. Clin Exp Nephrol; 2005 Jun;9(2):179-82
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  • [Title] Tuberous sclerosis, associated with renal cell carcinoma and angiomyolipoma, in a patient who developed endstage renal failure after nephrectomy.
  • We report a case of tuberous sclerosis (TSC) associated with renal cell carcinoma and angiomyolipoma in a patient, who developed endstage renal failure that required hemodialysis after nephrectomy.
  • A 37-year-old woman with TSC was admitted for further investigation of bilateral renal masses detected by computed tomography (CT).
  • Angiography revealed a tumor stain (4 cm in diameter) in the medial portion of the right kidney.
  • Because renal cell carcinoma (RCC) was strongly suspected, right nephrectomy was performed.
  • Her renal function deteriorated quickly (in 1(1/2) years) after the right nephrectomy, and hemodialysis was introduced the next year.
  • The histological findings of the resected right kidney revealed marked intimal thickening of the intralobular arteries.
  • These findings suggested that the renal function loss was not only caused by the nephron mass reduction due to the nephrectomy but was also caused by nephrosclerosis.
  • Though most patients with TSC die before developing endstage renal failure, this patient is currently receiving maintenance hemodialysis and has been followed for 3 years with no recurrence of RCC in the left kidney.
  • [MeSH-major] Angiomyolipoma / complications. Carcinoma, Renal Cell / complications. Kidney Failure, Chronic / pathology. Kidney Neoplasms / complications. Nephrectomy. Tuberous Sclerosis / etiology


29. Sandstrom CK, Pugsley J, Mitsumori LM: Renal angiomyolipoma with nontraumatic pulmonary fat embolus. AJR Am J Roentgenol; 2009 Jun;192(6):W275-6
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  • [Title] Renal angiomyolipoma with nontraumatic pulmonary fat embolus.
  • [MeSH-major] Angiomyolipoma / complications. Angiomyolipoma / radiography. Kidney Diseases / complications. Kidney Diseases / radiography. Pulmonary Embolism / etiology. Pulmonary Embolism / radiography. Vascular Neoplasms / complications. Vascular Neoplasms / radiography

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  • (PMID = 19457788.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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30. Yang Y, Sun S, Xiao X, Song Y, Cai W, Wang M, Zhang X: Temporary balloon occlusion of inferior vena cava in resection of renal tumor with vena cava thrombus extension. Urology; 2009 Mar;73(3):645-8
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  • [Title] Temporary balloon occlusion of inferior vena cava in resection of renal tumor with vena cava thrombus extension.
  • OBJECTIVES: To investigate a novel and effective method to occlude the inferior vena cava (IVC) during surgical management of a renal tumor with a tumor thrombus extension into the IVC.
  • METHODS: We retrospectively reviewed the records of 10 patients with renal cell carcinoma or renal angiomyolipoma with tumor thrombus extending into the IVC who had undergone surgical intervention at our institute from May 2005 to May 2006.
  • CONCLUSIONS: Temporary balloon occlusion of the IVC is a simple and reliable technique that decreases the risk of pulmonary embolism and facilitates the resection of renal tumor with levels II and III IVC thrombus.
  • [MeSH-major] Balloon Occlusion. Carcinoma, Renal Cell / secondary. Carcinoma, Renal Cell / surgery. Kidney Neoplasms / pathology. Kidney Neoplasms / surgery. Neoplastic Cells, Circulating. Vena Cava, Inferior

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  • [CommentIn] Eur Urol. 2009 Nov;56(5):883-4 [20965033.001]
  • (PMID = 19167042.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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31. Boorjian SA, Sheinin Y, Crispen PL, Lohse CM, Kwon ED, Leibovich BC: Hormone receptor expression in renal angiomyolipoma: clinicopathologic correlation. Urology; 2008 Oct;72(4):927-32
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  • [Title] Hormone receptor expression in renal angiomyolipoma: clinicopathologic correlation.
  • OBJECTIVES: Although renal angiomyolipoma (AML) occurs more commonly in females than males, the origin of this difference in incidence by sex is unknown.
  • Therefore, we investigated the expression of the androgen receptor (AR), estrogen receptor subtypes alpha (ERalpha) and beta (ERbeta), progesterone receptor, and the enzyme aromatase in renal AML.
  • METHODS: We evaluated specimens from 110 patients who had undergone resection of a renal AML, including 90 women and 20 men.
  • The level of ERbeta expression was not associated with patient age (P = 0.92), sex (P = 0.82), a diagnosis of tuberous sclerosis (P = 0.56), or histologic subtype of AML (P = 0.94).
  • CONCLUSIONS: The results of our study have shown that ERbeta expression is ubiquitous in renal AML, and the AR is found in most tumors.
  • These data suggest a potential role for hormones in the pathogenesis and management of renal AML.
  • [MeSH-major] Angiomyolipoma / metabolism. Aromatase / biosynthesis. Kidney Neoplasms / metabolism. Receptors, Androgen / biosynthesis. Receptors, Estrogen / biosynthesis. Receptors, Progesterone / biosynthesis

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  • (PMID = 18374399.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01 CA134345; United States / NCI NIH HHS / CA / R01 CA134345-01A1
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Androgen; 0 / Receptors, Estrogen; 0 / Receptors, Progesterone; EC 1.14.14.1 / Aromatase
  • [Other-IDs] NLM/ NIHMS160064; NLM/ PMC2789392
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32. La Parra Casado C, Muro Velilla D, Molina Fàbrega R, Sangüesa Nebot C: [Radiologic findings in non-Wilms' renal tumors in children]. Radiologia; 2008 May-Jun;50(3):215-24
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  • [Title] [Radiologic findings in non-Wilms' renal tumors in children].
  • OBJECTIVES: To analyze the radiologic findings of non-Wilms' renal tumors in children.
  • MATERIAL AND METHODS: This is a retrospective study of 26 patients with histologically confirmed non-Wilms' renal tumors.
  • RESULTS: We found 11 mesoblastic nephromas (predominantly solid masses, ill-defined margins, necrosis, hemorrhage, and peritumoral collections; mean patient age, 15 years old); 7 multilocular cystic nephromas (multicystic masses, thickened septa, well-defined margins, capsule, and partial involvement of the kidney; patient age range: 5 to 12 months); 4 renal carcinomas (one with dense calcifications, one mass in the pyelocaliceal system, one with infiltration of the excretory tract, one solid infiltrating mass, retroperitoneal adenopathies, and one metastasis; age range: 2 to 15 years); one clear cell sarcoma (circumscribed solid mass with necrosis and retrocaval adenopathy in a two-year-old boy); one rhabdoid tumor (hypodense mass, ill-defined margins, retroperitoneal adenopathy, vesical clots, and synchronous intracranial tumor, in a six-month-old boy); one intrarenal neuroblastoma (infiltrating solid mass, necrosis, retroperitoneal adenopathy, and bone marrow infiltration in an eight-year-old boy); and one angiomyolipoma (tumor in the upper pole, extrarenal growth, hypoenhancing, and two fatty lesions in the contralateral kidney, in a ten-year-old patient with tuberous sclerosis).
  • CONCLUSIONS: Radiology, together with clinical and epidemiological data, enables the diagnostic work-up of pediatric renal tumors.
  • Histological diagnosis remains indispensable.
  • [MeSH-major] Kidney Neoplasms / diagnosis

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  • (PMID = 18471386.001).
  • [ISSN] 0033-8338
  • [Journal-full-title] Radiología
  • [ISO-abbreviation] Radiologia
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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33. Lee SY, Hsu HH, Chen YC, Huang CC, Wong YC, Wang LJ, Chuang CK, Yang CW: Embolization of renal angiomyolipomas: short-term and long-term outcomes, complications, and tumor shrinkage. Cardiovasc Intervent Radiol; 2009 Nov;32(6):1171-8
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  • [Title] Embolization of renal angiomyolipomas: short-term and long-term outcomes, complications, and tumor shrinkage.
  • This study retrospectively evaluated outcomes, complications, and tumor shrinkage in renal angiomyolipomas after transcatheter arterial embolization (TAE).
  • All renal angiomyolipoma patients who underwent TAE between August 2000 and December 2008 and had short-term (<or=6 months) or long-term (>6 months) follow-up images were evaluated.
  • Eleven renal angiomyolipoma patients who had undergone TAE were included.
  • In conclusion, selective TAE is effective for tumor shrinkage in most renal angiomyolipomas, with acceptable complication and relapse rates.
  • [MeSH-major] Angiomyolipoma / therapy. Embolization, Therapeutic / methods. Kidney Neoplasms / therapy

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  • (PMID = 19572171.001).
  • [ISSN] 1432-086X
  • [Journal-full-title] Cardiovascular and interventional radiology
  • [ISO-abbreviation] Cardiovasc Intervent Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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34. Simpson E, Patel U: Diagnosis of angiomyolipoma using computed tomography-region of interest &lt; or =-10 HU or 4 adjacent pixels &lt; or =-10 HU are recommended as the diagnostic thresholds. Clin Radiol; 2006 May;61(5):410-6
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  • [Title] Diagnosis of angiomyolipoma using computed tomography-region of interest < or =-10 HU or 4 adjacent pixels < or =-10 HU are recommended as the diagnostic thresholds.
  • AIM: To study and compare the diagnostic accuracy of region of interest (ROI) density measurement and pixel mapping [computed tomography (CT) density of individual pixels] for the diagnosis of renal angiomyolipoma (AML) using CT.
  • MATERIALS AND METHODS: A study group of histologically proven AMLs was compared with a control group of histologically proven renal cell cancers, normal renal parenchyma, and simple renal cysts.
  • RESULTS: Twenty-two AMLs, 16 renal cell carcinomas (RCCs), 30 simple cysts, and 30 sites of renal parenchyma were evaluated.
  • The mean (+/-1 SD) density of the AMLs was significantly lower [-15.2(20.8) units] than the three control groups [+36.0(8.1) units, +5.4(3.4) units and +22.2(46.5) units for RCC, renal cyst and parenchyma respectively; p < 0.001 (analysis of variance)].
  • [MeSH-major] Angiomyolipoma / radiography. Kidney Neoplasms / radiography. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Adult. Carcinoma, Renal Cell / radiography. Cross-Sectional Studies. Diagnosis, Differential. Female. Humans. Kidney / radiography. Kidney Diseases, Cystic / radiography. Male. Middle Aged. Radiographic Image Interpretation, Computer-Assisted / methods. Retrospective Studies. Sensitivity and Specificity

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  • (PMID = 16679114.001).
  • [ISSN] 0009-9260
  • [Journal-full-title] Clinical radiology
  • [ISO-abbreviation] Clin Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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35. Crino PB, Aronica E, Baltuch G, Nathanson KL: Biallelic TSC gene inactivation in tuberous sclerosis complex. Neurology; 2010 May 25;74(21):1716-23
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  • AML = angiomyolipoma; DN = dysplastic neuron; FFPE = formalin fixed, paraffin embedded; GC = giant cell; H-E = hematoxylin and eosin; LOH = loss of heterozygosity; TSC = tuberous sclerosis complex.

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  • (PMID = 20498439.001).
  • [ISSN] 1526-632X
  • [Journal-full-title] Neurology
  • [ISO-abbreviation] Neurology
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / 5R01CA114478-02; United States / NCI NIH HHS / CA / 5R01CA118871-02; United States / NINDS NIH HHS / NS / 5R01NS045021-07; United States / NINDS NIH HHS / NS / 5R01NS048557-02
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Messenger; 0 / Ribosomal Protein S6; 0 / Tumor Suppressor Proteins; 0 / tuberous sclerosis complex 1 protein; 4JG2LF96VF / tuberous sclerosis complex 2 protein
  • [Other-IDs] NLM/ PMC2882213
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36. Larrea JS, Pino LB, Cabrera RS, Mena AL: Urological conservative management of a patient with tuberous sclerosis complex (Bourneville disease). Arch Esp Urol; 2009 Sep;62(7):596-9
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  • [Title] Urological conservative management of a patient with tuberous sclerosis complex (Bourneville disease).
  • OBJECTIVE: To report the clinical and radiological data of a 23-year-woman with bilateral angiomyolipoma and Tuberous Sclerosis with conservative treatment.
  • CONCLUSIONS: Renal lesions associated with tuberous sclerosis are frequent and serious.
  • Monitoring should be based on a careful monitoring since the renal lesions are the second death cause after the lesions of the nervous system.
  • [MeSH-major] Angiomyolipoma / therapy. Kidney Neoplasms / therapy. Tuberous Sclerosis / complications


37. D'Antonio A, Caleo A, Caleo O, De Dominicis G, Boscaino A: Monotypic epithelioid angiomyolipoma of the adrenal gland: an unusual site for a rare extrarenal tumor. Ann Diagn Pathol; 2009 Oct;13(5):347-50
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  • [Title] Monotypic epithelioid angiomyolipoma of the adrenal gland: an unusual site for a rare extrarenal tumor.
  • Epithelioid angiomyolipoma (AML) is an uncommon renal mesenchymal tumor with malignant potential and is frequently associated with tuberous sclerosis.
  • Extrarenal AMLs are rare, and to the best of our knowledge, this is the first reported case of a primary monotypic epithelioid AML of adrenal gland in a patient without evidence of tuberous sclerosis.
  • Differential diagnosis from renal cell carcinoma, adrenal gland carcinoma, and metastatic carcinoma is often challenging because of its epithelioid morphology.
  • Because primary and secondary malignant tumors are much more common and aggressive neoplasms, establishing the correct diagnosis has important therapeutic and prognostic implications.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Angiomyolipoma / pathology
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adrenalectomy. Adult. Biomarkers, Tumor / analysis. Carcinoma, Renal Cell / diagnosis. Diagnosis, Differential. Disease-Free Survival. Epithelioid Cells / chemistry. Epithelioid Cells / pathology. Hemorrhage / etiology. Hemorrhage / pathology. Humans. Male. Neoplasm Metastasis. Nephrectomy. Retroperitoneal Space / pathology. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 19751913.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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38. Andaleeb A, Sachdev R: Jejunal angiomyolipoma. Indian J Pathol Microbiol; 2010 Oct-Dec;53(4):859
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  • [Title] Jejunal angiomyolipoma.
  • [MeSH-major] Angiomyolipoma / diagnosis. Angiomyolipoma / pathology. Jejunal Neoplasms / diagnosis. Jejunal Neoplasms / pathology

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  • [CommentOn] Indian J Pathol Microbiol. 2007 Jul;50(3):568-9 [17883138.001]
  • (PMID = 21045449.001).
  • [ISSN] 0974-5130
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Comment; Letter
  • [Publication-country] India
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39. Linam LE, Yu X, Calvo-Garcia MA, Rubio EI, Crombleholme TM, Bove K, Kline-Fath BM: Contribution of magnetic resonance imaging to prenatal differential diagnosis of renal tumors: report of two cases and review of the literature. Fetal Diagn Ther; 2010;28(2):100-8
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  • [Title] Contribution of magnetic resonance imaging to prenatal differential diagnosis of renal tumors: report of two cases and review of the literature.
  • Enlargement of a kidney on prenatal imaging is usually due to hydronephrosis or cystic renal disease, and much less often results from solid tumors such as mesoblastic nephroma, Wilms' tumor, nephroblastomatosis, renal sarcoma, and angiomyolipoma.
  • Magnetic resonance imaging is useful not only in confirming the presence of a renal mass, but also in the evaluation of the contralateral kidney for subtle abnormalities.
  • [MeSH-major] Kidney Neoplasms / pathology. Nephroma, Mesoblastic / pathology. Prenatal Diagnosis / methods. Wilms Tumor / pathology
  • [MeSH-minor] Adolescent. Adult. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Pregnancy

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  • [Copyright] Copyright (c) 2010 S. Karger AG, Basel.
  • (PMID = 20587988.001).
  • [ISSN] 1421-9964
  • [Journal-full-title] Fetal diagnosis and therapy
  • [ISO-abbreviation] Fetal. Diagn. Ther.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Switzerland
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40. Kothary N, Soulen MC, Clark TW, Wein AJ, Shlansky-Goldberg RD, Crino PB, Stavropoulos SW: Renal angiomyolipoma: long-term results after arterial embolization. J Vasc Interv Radiol; 2005 Jan;16(1):45-50
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  • [Title] Renal angiomyolipoma: long-term results after arterial embolization.
  • PURPOSE: Selective arterial embolization of renal angiomyolipomas (AMLs) was performed to prevent hemorrhage in patients with AMLs larger than 4 cm.
  • MATERIALS AND METHODS: Nineteen patients underwent embolization for 30 renal AMLs between July 1991 and June 2002.
  • RESULTS: Embolization of the renal AMLs was technically successful in all 19 patients and for all 30 lesions.
  • Six lesions in four patients had to be reembolized because of recurrent symptoms, including one hemorrhage, and three lesions in two patients required repeat embolization because of a greater than 2 cm increase in size.
  • CONCLUSIONS: Transarterial embolization is effective in preventing hemorrhage in patients with renal AMLs.
  • [MeSH-major] Angiomyolipoma / therapy. Embolization, Therapeutic. Kidney Neoplasms / therapy

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  • [CommentIn] J Vasc Interv Radiol. 2005 Aug;16(8):1153-4; author reply 1154 [16105930.001]
  • (PMID = 15640409.001).
  • [ISSN] 1051-0443
  • [Journal-full-title] Journal of vascular and interventional radiology : JVIR
  • [ISO-abbreviation] J Vasc Interv Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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41. Oishi K, Fukuda S, Sakimoto H, Eto T, Takahashi M, Nishida T: Angiomyolipoma of the colon: report of a case. Surg Today; 2009;39(11):998-1001
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  • [Title] Angiomyolipoma of the colon: report of a case.
  • Angiomyolipomas are benign mesenchymal tumors mostly arising from the kidney.
  • Angiomyolipoma of the colon is extremely rare.
  • Here we report the findings of a 51-year-old man who presented with a submucosal tumor covered with normal mucosa and hemorrhage in the descending colon.
  • A histopathological examination showed that the tumor of 5.7 cm in diameter included smooth muscle (spindle cell type), mature adipose tissue, and vessels, and therefore a diagnosis of angiomyolipoma was made.
  • A submucosal type of angiomyolipoma of the colon is extremely rare.
  • If a renal angiomyolipoma is larger than 4 cm, there is a risk of rupture.
  • When colonoscopy shows a submucosal tumor of the colon with hemorrhage, angiomyolipoma should be considered.
  • If an angiomyolipoma of the colon is large, surgical resection should be considered as a treatment option due to the risk of hemorrhage.
  • [MeSH-minor] Biopsy. Colonoscopy. Diagnosis, Differential. Humans. Male. Middle Aged

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  • [Cites] Am J Surg Pathol. 2002 Apr;26(4):523-9 [11914633.001]
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  • (PMID = 19882325.001).
  • [ISSN] 1436-2813
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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42. Chan SY, Chan WK: Huge renal angiomyolipomas in tuberous sclerosis complex. Nephrology (Carlton); 2005 Aug;10(4):382-6
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  • [Title] Huge renal angiomyolipomas in tuberous sclerosis complex.
  • Tuberous sclerosis complex (TSC) is an autosomal dominance disorder with variable penetrance.
  • Renal angiomyolipoma (AML) is one of the commonest urological manifestations.
  • We report two patients with multiple and huge renal angiomyolipomas presenting with gross haematuria.
  • The difficulty in diagnosis and controversies in management will be briefly discussed.
  • [MeSH-major] Angiomyolipoma / etiology. Kidney Neoplasms / etiology. Tuberous Sclerosis / complications

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  • (PMID = 16109086.001).
  • [ISSN] 1320-5358
  • [Journal-full-title] Nephrology (Carlton, Vic.)
  • [ISO-abbreviation] Nephrology (Carlton)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins; 0 / Tumor Suppressor Proteins; 0 / tuberous sclerosis complex 1 protein; 4JG2LF96VF / tuberous sclerosis complex 2 protein
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43. Taouli B, Thakur RK, Mannelli L, Babb JS, Kim S, Hecht EM, Lee VS, Israel GM: Renal lesions: characterization with diffusion-weighted imaging versus contrast-enhanced MR imaging. Radiology; 2009 May;251(2):398-407
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  • [Title] Renal lesions: characterization with diffusion-weighted imaging versus contrast-enhanced MR imaging.
  • PURPOSE: To compare the diagnostic performance of diffusion-weighted (DW) magnetic resonance (MR) imaging with that of contrast material-enhanced (CE) MR imaging and to assess the performance of these examinations combined for the characterization of renal lesions, with MR follow-up and histopathologic analysis as the reference standards.
  • One hundred nine renal lesions in 64 patients (46 men, 18 women; mean age, 60.7 years) were evaluated with CE MR imaging and breath-hold DW imaging performed with various b values.
  • Renal lesions were characterized with use of CE MR criteria, and apparent diffusion coefficients (ADCs) were measured.
  • Receiver operating characteristic (ROC) analysis was performed to assess the accuracy of DW imaging and CE MR imaging in the diagnosis of renal cell carcinoma (RCC).
  • RESULTS: The 109 renal lesions--81 benign lesions and 28 RCCs--had a mean diameter of 4.2 cm +/- 2.5 (standard deviation).
  • At a cutoff ADC of less than or equal to 1.92 x 10(-3) mm(2)/sec, the area under the ROC curve (AUC), sensitivity, and specificity of DW imaging for the diagnosis of RCCs (excluding angiomyolipomas) were 0.856, 86%, and 80%, respectively.
  • The AUC for the DW imaging-based diagnosis of solid RCC versus oncocytoma was 0.854.
  • CONCLUSION: DW imaging can be used to characterize renal lesions; however, compared with CE MR imaging, it is less accurate.
  • [MeSH-major] Diffusion Magnetic Resonance Imaging / methods. Gadolinium DTPA. Image Enhancement / methods. Kidney Neoplasms / diagnosis

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  • (PMID = 19276322.001).
  • [ISSN] 1527-1315
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; K2I13DR72L / Gadolinium DTPA
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44. Raft J, Lalot JM, Meistelman C, Longrois D: [Renal angiomyolipoma rupture during pregnancy]. Gynecol Obstet Fertil; 2006 Oct;34(10):917-9
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  • [Title] [Renal angiomyolipoma rupture during pregnancy].
  • [Transliterated title] Rupture d'un angiomyolipome rénal lors d'une grossesse.
  • A 40 year-old 2nd gesta pregnant woman (34.5 weeks of amenorhea) was admitted to hospital for abdominal pain and arterial hypotension which were rapidly related to a retroperitoneal haematoma due to left kidney bleeding.
  • Exploration of the retroperitonal space after foetal extraction confirmed the presence of a large haematoma and abnormal left renal morphology.
  • Subsequently, abdominal and thoracic computerised tomographic examination showed bilateral dysplasia of the kidneys and pulmonary cysts consistent with the diagnosis of renal angiomyolipoma and pulmonary lymphangioleiomyomatosis.
  • The case report is of interest because of the circumstances of discovery of the disease and because nephrectomy was not necessary to control the bleeding of the left kidney.
  • [MeSH-major] Angiomyolipoma / diagnosis. Kidney Neoplasms / diagnosis. Pregnancy Complications, Neoplastic / diagnosis
  • [MeSH-minor] Adult. Cesarean Section. Female. Hematoma / therapy. Hemorrhage / etiology. Hemorrhage / therapy. Humans. Kidney / blood supply. Pregnancy. Retroperitoneal Space. Rupture, Spontaneous. Tomography, X-Ray Computed

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  • (PMID = 16996772.001).
  • [ISSN] 1297-9589
  • [Journal-full-title] Gynécologie, obstétrique & fertilité
  • [ISO-abbreviation] Gynecol Obstet Fertil
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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46. Parfitt JR, Bella AJ, Izawa JI, Wehrli BM: Malignant neoplasm of perivascular epithelioid cells of the liver. Arch Pathol Lab Med; 2006 Aug;130(8):1219-22
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  • Although this group includes entities with distinct clinical features, such as angiomyolipoma, clear cell sugar tumor of the lung, and lymphangioleiomyomatosis, similar tumors have been documented in an increasing diversity of locations.
  • The term PEComa is now generally used in reference to these lesions that are not angiomyolipomas, clear cell sugar tumors, or lymphangioleiomyomatoses.
  • This case represents the second documented malignant PEComa of the liver, as well as the longest follow-up of a surviving patient with a malignant PEComa, emphasizing both the need for criteria that more accurately predict the behavior of PEComas and the necessity of long-term follow-up of patients with PEComas.

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  • (PMID = 16879028.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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47. Inci O, Kaplan M, Yalcin O, Atakan IH, Kubat H: Renal angiomyolipoma with malignant transformation, simultaneous occurrence with malignity and other complex clinical situations. Int Urol Nephrol; 2006;38(3-4):417-26
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  • [Title] Renal angiomyolipoma with malignant transformation, simultaneous occurrence with malignity and other complex clinical situations.
  • Renal angiomyolipoma is a benign kidney tumor, which is characterized by the presence of mature or immature fat tissue, thick-walled blood vessels, and smooth muscles.
  • And also angiomyolipoma could be associated with renal adenocarcinoma in the same kidney.
  • The aim of this study is to show the association of angiomyolipoma with complex clinical situations such as malign transformation, simultaneous occurrence with adenocarcinoma, bilateral tumors with tuberous sclerosis or Wunderlich Syndrome.
  • Findings of clinical presentation, pathological evaluation, urography, ultrasonography, and computerized tomography of 19 patients who were diagnosed angiomyolipoma in our clinic during 1994-2003 were examined retrospectively.
  • Our records indicated that radical nephrectomy was performed in three cases of angiomyolipoma in which the differential diagnosis from adenocarcinoma could not be made and in another case of angiomyolipoma, which was associated with adenocarcinoma.
  • Simple nephrectomy was performed in four symptomatic angiomyolipoma cases with tumor size larger than 4 cm and partial nephrectomy in another case.
  • In one case, renal angiomyolipoma was associated with adenocarcinoma in the same kidney.
  • In one case, post-operative recurrence of angiomyolipoma developed 7 months after nephrectomy.
  • Angiomyolipoma is regarded as a benign tumor of the kidney; however, it may also show aggressive behaviors and rarely transform to sarcoma.
  • It may also exist in the same kidney along with adenocarcinoma or sarcoma.
  • [MeSH-major] Angiomyolipoma / pathology. Kidney Neoplasms / pathology. Neoplasms, Multiple Primary / pathology

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  • (PMID = 17033887.001).
  • [ISSN] 0301-1623
  • [Journal-full-title] International urology and nephrology
  • [ISO-abbreviation] Int Urol Nephrol
  • [Language] eng
  • [Publication-type] Journal Article
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48. Singh K, Pai RR, Kini H, Kini UA: Cutaneous angiomyolipoma. Indian J Pathol Microbiol; 2009 Apr-Jun;52(2):242-3
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  • [Title] Cutaneous angiomyolipoma.
  • Cutaneous angiomyolipomas are rare.
  • This lesion, probably hamartomatous in nature, differs from renal angiomyolipoma in terms of nonassociation with tuberous sclerosis, circumscription, and male predominance.
  • Differential diagnosis includes angiolipoma, angioleiomyoma, hemangioma, and myolipoma.
  • It is distinguished from the abovementioned entities by the presence of a combination of thick-walled blood vessels, smooth muscle, and fat.
  • [MeSH-major] Angiomyolipoma / diagnosis. Chin / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged

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  • (PMID = 19332927.001).
  • [ISSN] 0974-5130
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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49. Sukumar S, Balagopal Nair T, Mohammed Saheed CS, Sanjay Bhat H: Bilateral nephron sparing surgeries for multiple renal angiomyolipomas in Bourneville's disease. Int Urol Nephrol; 2007;39(2):389-91
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  • [Title] Bilateral nephron sparing surgeries for multiple renal angiomyolipomas in Bourneville's disease.
  • INTRODUCTION: Angiomyolipomas are the most common renal lesions in tuberous sclerosis complex.
  • CASE-HISTORY: A 22-year-old lady with bilateral multiple large symptomatic renal angiomyolipomas associated with other manifestations of tuberous sclerosis was managed with partial nephrectomies on either side.
  • At 30 months of follow-up, the patient has normal renal functions and no evidence of recurrence.
  • DISCUSSION: Intervention for renal angiomyolipomas is indicated in symptomatic tumors larger than four centimetres.
  • Nephron sparing surgery of both kidneys for angiomyolipomas in association with tuberous sclerosis has only been sparingly reported in literature.
  • [MeSH-major] Angiomyolipoma / surgery. Kidney Neoplasms / surgery. Nephrectomy / methods. Tuberous Sclerosis / complications

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  • (PMID = 17004032.001).
  • [ISSN] 0301-1623
  • [Journal-full-title] International urology and nephrology
  • [ISO-abbreviation] Int Urol Nephrol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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50. Lesma E, Sirchia SM, Ancona S, Carelli S, Bosari S, Ghelma F, Montanari E, Di Giulio AM, Gorio A: The methylation of the TSC2 promoter underlies the abnormal growth of TSC2 angiomyolipoma-derived smooth muscle cells. Am J Pathol; 2009 Jun;174(6):2150-9
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  • [Title] The methylation of the TSC2 promoter underlies the abnormal growth of TSC2 angiomyolipoma-derived smooth muscle cells.
  • Tuberous sclerosis complex (TSC) is an autosomal-dominant disease that is caused by mutations in either the TSC1 or TSC2 gene.
  • Smooth muscle-like cells (ASMs) were isolated from an angiomyolipoma of a patient with TSC.
  • Our data show for the first time that methylation of the TSC2 promoter might cause a complete loss of tuberin in TSC2 cells, and that the pathogenesis of angiomyolipomas might also originate from epigenetic defects in smooth muscle cells.
  • [MeSH-major] Angiomyolipoma / genetics. Angiomyolipoma / pathology. DNA Methylation / genetics. Myocytes, Smooth Muscle / pathology. Tumor Suppressor Proteins / genetics
  • [MeSH-minor] Adult. Antibiotics, Antineoplastic / pharmacology. Antigens, Neoplasm. Apoptosis / drug effects. Blotting, Western. Cell Proliferation / drug effects. DNA Mutational Analysis. Germ-Line Mutation. Humans. Immunohistochemistry. In Situ Nick-End Labeling. Kidney Neoplasms / genetics. Kidney Neoplasms / metabolism. Kidney Neoplasms / pathology. Male. Melanoma-Specific Antigens. Microscopy, Fluorescence. Neoplasm Proteins. Promoter Regions, Genetic / genetics. Sirolimus / pharmacology. Tuberous Sclerosis / complications. Tuberous Sclerosis / genetics. Tuberous Sclerosis / pathology

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  • (PMID = 19443708.001).
  • [ISSN] 1525-2191
  • [Journal-full-title] The American journal of pathology
  • [ISO-abbreviation] Am. J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Antigens, Neoplasm; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins; 0 / Tumor Suppressor Proteins; 4JG2LF96VF / tuberous sclerosis complex 2 protein; W36ZG6FT64 / Sirolimus
  • [Other-IDs] NLM/ PMC2684180
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51. Setola SV, Catalano O, Sandomenico F, Siani A: Contrast-enhanced sonography of the kidney. Abdom Imaging; 2007 Jan-Feb;32(1):21-8
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  • [Title] Contrast-enhanced sonography of the kidney.
  • Contrast-enhanced sonography (CEUS) is a recently introduced, promising technique in the evaluation of the kidney.
  • CEUS allows real-time assessment of normal and abnormal renal perfusions.
  • US contrast media are not nephrotoxic and can be employed safely, even in subjects with impaired renal function.
  • There are several clinical scenarios where CEUS may play the role of a low-cost, scarcely invasive tool, including renal tumors (with special reference to small, indeterminate masses, i.e., differentiation between carcinoma and angiomyolipoma), renal atypical cystic masses (i.e., differentiation of malignant from benign cysts and follow-up of cystic lesions managed conservatively), renal infarction, renal infections, and renal injuries.
  • In addition, CEUS can be useful in the assessment of renal pseudotumors (including any case with possible renal mass on conventional US imaging) and has been employed in radiofrequency ablation guidance.
  • This pictorial review illustrates the CEUS findings recognizable in a wide spectrum of renal disorders and discusses the strengths and limitations of renal imaging with CEUS.
  • [MeSH-major] Contrast Media. Image Enhancement / methods. Kidney / ultrasonography. Kidney Diseases / ultrasonography
  • [MeSH-minor] Adult. Aged. Angiomyolipoma / ultrasonography. Carcinoma / ultrasonography. Catheter Ablation. Female. Humans. Infarction / ultrasonography. Kidney Diseases, Cystic / ultrasonography. Kidney Neoplasms / ultrasonography. Male. Microbubbles. Microcirculation / ultrasonography. Middle Aged. Phospholipids. Pyelonephritis / ultrasonography. Sulfur Hexafluoride. Ultrasonography, Doppler / methods. Ultrasonography, Interventional

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  • (PMID = 17420958.001).
  • [ISSN] 0942-8925
  • [Journal-full-title] Abdominal imaging
  • [ISO-abbreviation] Abdom Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Phospholipids; 0 / contrast agent BR1; WS7LR3I1D6 / Sulfur Hexafluoride
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52. Eloubeidi MA, Morgan DE, Cerfolio RJ, Eltoum IA: Transduodenal EUS-guided FNA of the right adrenal gland. Gastrointest Endosc; 2008 Mar;67(3):522-7
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  • Four passes were performed in all cases, and the diagnosis was rendered on the first pass.
  • One patient had a benign aspirate consistent with angiomyolipoma.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Adrenal Glands / pathology. Biopsy, Fine-Needle / methods. Carcinoma / diagnosis. Endosonography / methods

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  • (PMID = 18234198.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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53. Jaff A, Molinié V, Mellot F, Guth A, Lebret T, Scherrer A: Evaluation of imaging-guided fine-needle percutaneous biopsy of renal masses. Eur Radiol; 2005 Aug;15(8):1721-6
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  • [Title] Evaluation of imaging-guided fine-needle percutaneous biopsy of renal masses.
  • To evaluate the utility of imaging-guided fine-needle percutaneous biopsy of renal masses, we conducted a prospective analysis of our imaging-guided procedures from January 1999 to February 2003.
  • Biopsy findings were positive for malignancy in 31 cases; histologic diagnoses included renal cell carcinoma (n=23), transitional cell carcinoma (n=5), and metastasis (n=3).
  • Biopsy revealed 15 benign diagnoses: oncocytoma (n=6), hemorrhagic renal cyst (n=3), chronic nephritis (n=3), angiomyolipoma (n=2), and mycotic renal abscess (n=1).
  • Biopsy results showed normal renal parenchyma in eight of 54 procedures, all of which had recuperated by subsequent biopsies.
  • Imaging-guided percutaneous core biopsy is a safe and accurate method for the evaluation of renal masses.
  • [MeSH-major] Biopsy, Fine-Needle / methods. Kidney Diseases / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Kidney Neoplasms / diagnosis. Kidney Neoplasms / diagnostic imaging. Male. Middle Aged. Tomography, X-Ray Computed. Ultrasonography

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  • [CommentIn] Eur Radiol. 2006 Aug;16(8):1857 [16395535.001]
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  • (PMID = 15627185.001).
  • [ISSN] 0938-7994
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Germany
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54. Morales JP, Georganas M, Khan MS, Dasgupta P, Reidy JF: Embolization of a bleeding renal angiomyolipoma in pregnancy: case report and review. Cardiovasc Intervent Radiol; 2005 Mar-Apr;28(2):265-8
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  • [Title] Embolization of a bleeding renal angiomyolipoma in pregnancy: case report and review.
  • A case is described of a woman 10 weeks pregnant who had severe bleeding, secondary to a renal angiomyolipoma (AML), that was treated with embolization.
  • [MeSH-major] Angiomyolipoma / therapy. Embolization, Therapeutic / methods. Hemorrhage / therapy. Kidney Neoplasms / therapy. Pregnancy Complications, Hematologic / therapy. Pregnancy Complications, Neoplastic / therapy
  • [MeSH-minor] Adult. Arteriovenous Malformations / therapy. Female. Hematoma / therapy. Humans. Kidney / blood supply. Pregnancy. Pregnancy Outcome

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  • (PMID = 15696353.001).
  • [ISSN] 0174-1551
  • [Journal-full-title] Cardiovascular and interventional radiology
  • [ISO-abbreviation] Cardiovasc Intervent Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 21
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55. Hornick JL, Fletcher CD: Sclerosing PEComa: clinicopathologic analysis of a distinctive variant with a predilection for the retroperitoneum. Am J Surg Pathol; 2008 Apr;32(4):493-501
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  • [Title] Sclerosing PEComa: clinicopathologic analysis of a distinctive variant with a predilection for the retroperitoneum.
  • PEComas (tumors showing perivascular epithelioid cell differentiation) are a family of mesenchymal neoplasms that include angiomyolipoma, clear cell "sugar" tumor of the lung, lymphangiomyomatosis, and a group of uncommon lesions that arise in soft tissue, visceral organs, and skin.

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  • (PMID = 18223480.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, Neoplasm; 0 / Calmodulin-Binding Proteins; 0 / Desmin; 0 / MART-1 Antigen; 0 / MITF protein, human; 0 / MLANA protein, human; 0 / Melanoma-Specific Antigens; 0 / Microphthalmia-Associated Transcription Factor; 0 / Mucin-1; 0 / Neoplasm Proteins; 0 / S100 Proteins; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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56. Barkagan ZS, Mamaev AN, Tsyvkina LP, Mamaeva IV: [Laboratory monitoring of recombinant factor VIIA effects]. Klin Lab Diagn; 2007 May;(5):23-5
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  • The paper presents the results of a study of various parameters of the hemostatic system in patients with profuse hemorrhages before and after the use of recombinant activated factor VII.
  • [MeSH-minor] Adolescent. Adult. Aged. Angiomyolipoma / complications. Angiomyolipoma / surgery. Blood Coagulation Tests. Colonic Neoplasms / complications. Colonic Neoplasms / surgery. Factor VIIa. Female. Humans. Kidney Neoplasms / complications. Kidney Neoplasms / surgery. Male. Middle Aged. Prostatic Neoplasms / complications. Prostatic Neoplasms / surgery. Recombinant Proteins / therapeutic use

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  • (PMID = 17665615.001).
  • [ISSN] 0869-2084
  • [Journal-full-title] Klinicheskaia laboratornaia diagnostika
  • [ISO-abbreviation] Klin. Lab. Diagn.
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Hemostatics; 0 / Recombinant Proteins; 0 / recombinant FVIIa; 9001-25-6 / Factor VII; EC 3.4.21.21 / Factor VIIa
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57. Walsh SN, Sangüeza OP: PEComas: a review with emphasis on cutaneous lesions. Semin Diagn Pathol; 2009 Aug;26(3):123-30
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  • The connection between angiomyolipoma (AML) of the kidney, clear cell sugar tumor (CCST) of the lung, and pulmonary lymphangioleiomyoma (LAM), was progressively discovered because of the histologic and immunophenotypic similarities between the three tumors and their frequent association with tuberous sclerosis complex (TSC).

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  • [CommentIn] Am J Dermatopathol. 2016 Feb;38(2):165-6 [26825164.001]
  • (PMID = 20043511.001).
  • [ISSN] 0740-2570
  • [Journal-full-title] Seminars in diagnostic pathology
  • [ISO-abbreviation] Semin Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Desmin; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins
  • [Number-of-references] 65
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58. Ciftci AO, Sanlialp I, Tanyel FC, Buyukpamukçu N: The association of pulmonary lymphangioleiomyomatosis with renal and hepatic angiomyolipomas in a prepubertal girl: a previously unreported entity. Respiration; 2007;74(3):335-7
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  • [Title] The association of pulmonary lymphangioleiomyomatosis with renal and hepatic angiomyolipomas in a prepubertal girl: a previously unreported entity.
  • Pulmonary lymphangioleiomyomatosis (PLAM) is a rare, diffuse progressive interstitial lung disease that affects females of childbearing age and is characterized by diffuse proliferation of abnormal smooth muscle fibers predominantly developing in the lung and leading to cystic destruction.
  • A prepubertal 13-year-old girl with PLAM associated with renal and hepatic angiomyolipomas who was treated by nephroureterectomy and thoracoscopic pleurodesis is presented.
  • To the best of our knowledge, this is the first reported case of PLAM associated with renal and hepatic angiomyolipomas at the prepubertal age.
  • After evaluating the clinicopathologic features of this rare entity, the authors conclude that PLAM should be considered in the differential diagnosis of cystic pulmonary pathologies in children, particularly teenagers.
  • The most important clinical aid is to bear this rare entity in mind when a child presents with renal and/or hepatic angiomyolipomas.
  • [MeSH-major] Angiomyolipoma. Kidney Neoplasms. Liver Neoplasms. Lung Neoplasms. Lymphangioleiomyomatosis. Neoplasms, Multiple Primary


59. Gayed BA, Jacobs BL, Gibbons EP, Hrebinko RL: Resection of a staggering 36-cm angiomyolipoma. Can Urol Assoc J; 2010 Aug;4(4):E97-9
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  • [Title] Resection of a staggering 36-cm angiomyolipoma.
  • Angiomyolipomas (AMLs) are benign tumours characterized by fat, smooth muscle and vascular components.
  • We present a case of a 41-year-old male who presented with light-headedness, dizziness, right-sided abdominal pain and, on subsequent computed tomography, was found to have an enormous right kidney mass characteristic of an AML.

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  • (PMID = 20694093.001).
  • [ISSN] 1920-1214
  • [Journal-full-title] Canadian Urological Association journal = Journal de l'Association des urologues du Canada
  • [ISO-abbreviation] Can Urol Assoc J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC2911987
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60. Orii M, Kakizaki S, Takagi H, Mori M: Education and imaging. Gastrointestinal: huge angiomyolipoma. J Gastroenterol Hepatol; 2006 Jan;21(1 Pt 2):330
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Education and imaging. Gastrointestinal: huge angiomyolipoma.
  • [MeSH-major] Angiomyolipoma / radiography. Kidney Neoplasms / radiography

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  • (PMID = 16460498.001).
  • [ISSN] 0815-9319
  • [Journal-full-title] Journal of gastroenterology and hepatology
  • [ISO-abbreviation] J. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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61. Ban D, Yamamoto S, Kuno H, Fujimoto H, Fujita S, Akasu T, Moriya Y: A case of huge colon carcinoma and right renal angiomyolipoma accompanied by proximal deep venous thrombosis, pulmonary embolism and tumor thrombus in the renal vein. Jpn J Clin Oncol; 2008 Oct;38(10):710-4
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  • [Title] A case of huge colon carcinoma and right renal angiomyolipoma accompanied by proximal deep venous thrombosis, pulmonary embolism and tumor thrombus in the renal vein.
  • The patient in the present report had two huge tumors, ascending colon cancer and renal angiomyolipoma, which occupied the entire right half of the abdomen, coexisting PE, DVT and tumor thrombus in the right renal vein.
  • [MeSH-major] Adenocarcinoma / pathology. Angiomyolipoma / pathology. Colonic Neoplasms / pathology. Kidney Neoplasms / pathology. Neoplasms, Second Primary / pathology. Pulmonary Embolism / etiology. Renal Veins / pathology. Thrombosis / etiology. Venous Thrombosis / etiology
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Tomography, X-Ray Computed. Vena Cava Filters


62. Sinn DH, Choi D, Choi MS, Park CK: [A case of hepatic angiomyolipoma mimicking hepatocellular carcinoma]. Korean J Gastroenterol; 2008 Jan;51(1):1-3
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  • [Title] [A case of hepatic angiomyolipoma mimicking hepatocellular carcinoma].
  • [MeSH-major] Angiomyolipoma / diagnosis. Liver Neoplasms / diagnosis
  • [MeSH-minor] Antigens, Neoplasm / immunology. Carcinoma, Hepatocellular / diagnosis. Carcinoma, Hepatocellular / pathology. Carcinoma, Hepatocellular / surgery. Diagnosis, Differential. Humans. Male. Melanoma-Specific Antigens. Middle Aged. Neoplasm Proteins / immunology. Tomography, X-Ray Computed

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  • (PMID = 18349555.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins
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63. Lu HC, Chau GY, Su CW: Clinical challenges and images in GI. Diagnosis: Hepatic angiomyolipoma mimicking hepatocellular carcinoma. Gastroenterology; 2009 Apr;136(4):1169, 1464
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical challenges and images in GI. Diagnosis: Hepatic angiomyolipoma mimicking hepatocellular carcinoma.
  • [MeSH-major] Angiomyolipoma / diagnosis. Carcinoma, Hepatocellular / diagnosis. Liver Neoplasms / diagnosis
  • [MeSH-minor] Angiography. Biopsy, Fine-Needle. Diagnosis, Differential. Female. Hepatic Artery / radiography. Humans. Mesenteric Arteries / radiography. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 19254682.001).
  • [ISSN] 1528-0012
  • [Journal-full-title] Gastroenterology
  • [ISO-abbreviation] Gastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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64. Inahara M, Takei K, Naito H, Eguchi M: [Extrarenal angiomyolipoma with spontaneous rupture: a case report]. Hinyokika Kiyo; 2008 Jul;54(7):485-8
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  • [Title] [Extrarenal angiomyolipoma with spontaneous rupture: a case report].
  • We present a very rare case of retroperitoneal extrarenal angiomyolipoma (AML) with spontaneous rupture.
  • We suspected right renal AML with rupture by imaging analysis, but the diagnosis was extrarenal AML by surgery and pathological examination.
  • [MeSH-major] Angiomyolipoma / pathology. Angiomyolipoma / surgery. Kidney Neoplasms / pathology. Kidney Neoplasms / surgery. Retroperitoneal Neoplasms / pathology. Retroperitoneal Neoplasms / surgery

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  • (PMID = 18697493.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 17
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65. Yu J, Parkhitko AA, Henske EP: Mammalian target of rapamycin signaling and autophagy: roles in lymphangioleiomyomatosis therapy. Proc Am Thorac Soc; 2010 Feb;7(1):48-53
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  • In the year 2000, TSC2 gene mutations were found in LAM cells; in 2001 the tuberous sclerosis complex (TSC) genes were discovered to regulate cell size in Drosophila via the kinase TOR (target of rapamycin); and in 2008 the results were published of a clinical trial of rapamycin, a specific inhibitor of TOR, in patients with TSC and LAM with renal angiomyolipomas.
  • This interval of just 8 years between a genetic discovery for which the relevant signaling pathway was as yet unknown, to the initiation, completion, and publication of a clinical trial, is an almost unparalleled accomplishment in modern biomedical research.
  • An immediate challenge is to deduce the mechanisms underlying the partial response of renal angiomyolipomas to rapamycin, and thereby guide the design of combinatorial approaches.
  • [MeSH-major] Angiomyolipoma / drug therapy. Autophagy / drug effects. Intracellular Signaling Peptides and Proteins / physiology. Lymphangioleiomyomatosis / drug therapy. Lymphangioleiomyomatosis / genetics. Protein-Serine-Threonine Kinases / physiology. Sirolimus / pharmacology. Tuberous Sclerosis / genetics

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  • (PMID = 20160148.001).
  • [ISSN] 1943-5665
  • [Journal-full-title] Proceedings of the American Thoracic Society
  • [ISO-abbreviation] Proc Am Thorac Soc
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Intracellular Signaling Peptides and Proteins; 0 / Tumor Suppressor Proteins; 4JG2LF96VF / tuberous sclerosis complex 2 protein; EC 2.7.1.1 / MTOR protein, human; EC 2.7.1.1 / TOR Serine-Threonine Kinases; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; W36ZG6FT64 / Sirolimus
  • [Number-of-references] 80
  • [Other-IDs] NLM/ PMC3137149
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66. Kollarik B, Romancik M, Obsitnik M: Growth rates are similar in potentially benign and malignant small renal masses detected incidentally. Bratisl Lek Listy; 2010;111(7):378-80
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  • [Title] Growth rates are similar in potentially benign and malignant small renal masses detected incidentally.
  • OBJECTIVE: Generally small renal masses grow at slow rate; some of them do not exhibit any growth.
  • The aim of our study was to compare the growth of enhancing, non-enhancing solid renal masses, angiomyolipomas and complex renal cystic masses < or =4 cm in diameter.
  • MATERIALS AND METHODS: 12 patients with solid enhancing, 20 with solid non-enhancing, 8 with angiomyolipomas and 25 with Bosniak II/IIF/III and IV masses were enrolled and prospectively studied during the surveillance period.
  • CONCLUSIONS: The vast majority of small solid and complex cystic renal masses exhibit similar slow growth rates.
  • [MeSH-major] Kidney Diseases, Cystic / pathology. Kidney Neoplasms / pathology
  • [MeSH-minor] Aged. Angiomyolipoma / pathology. Angiomyolipoma / radiography. Disease Progression. Humans. Incidental Findings. Middle Aged

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  • (PMID = 20806542.001).
  • [ISSN] 0006-9248
  • [Journal-full-title] Bratislavské lekárske listy
  • [ISO-abbreviation] Bratisl Lek Listy
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Slovakia
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67. Hsu YP, Chen RJ, Fang JF, Lin BC: Traumatic rupture of renal angiomyolipoma managed with angioembolization followed by elective surgery: a report of two cases. J Trauma; 2005 Sep;59(3):737-41
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  • [Title] Traumatic rupture of renal angiomyolipoma managed with angioembolization followed by elective surgery: a report of two cases.
  • [MeSH-major] Angiomyolipoma / complications. Angiomyolipoma / therapy. Elective Surgical Procedures. Embolization, Therapeutic. Kidney Neoplasms / complications. Kidney Neoplasms / therapy. Nephrectomy
  • [MeSH-minor] Accidents, Traffic. Adult. Algorithms. Aneurysm, Ruptured / radiography. Aneurysm, Ruptured / therapy. Angiography. Female. Humans. Middle Aged. Renal Artery. Rupture / radiography. Rupture / surgery. Tomography, X-Ray Computed

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  • (PMID = 16361922.001).
  • [ISSN] 0022-5282
  • [Journal-full-title] The Journal of trauma
  • [ISO-abbreviation] J Trauma
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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68. Mues AC, Palacios JM, Haramis G, Casazza C, Badani K, Gupta M, McKiernan J, Benson MC, Landman J: Contemporary experience in the management of angiomyolipoma. J Endourol; 2010 Nov;24(11):1883-6
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  • [Title] Contemporary experience in the management of angiomyolipoma.
  • PURPOSE: We review our single center experience in the management of renal angiomyolipoma (AML) in patients who were treated with active surveillance (AS) or invasive treatment protocols.
  • PATIENTS AND METHODS: A prospectively evaluated database was reviewed, and we identified 91 patients with the diagnosis of renal AML who presented between June 1985 and February 2009.
  • CONCLUSIONS: AML is a renal tumor that usually exhibits a benign course.

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  • (PMID = 20919915.001).
  • [ISSN] 1557-900X
  • [Journal-full-title] Journal of endourology
  • [ISO-abbreviation] J. Endourol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
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69. Byrd GF, Lawatsch EJ, Mesrobian HG, Begun F, Langenstroer P: Laparoscopic cryoablation of renal angiomyolipoma. J Urol; 2006 Oct;176(4 Pt 1):1512-6; discussion 1516
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Laparoscopic cryoablation of renal angiomyolipoma.
  • PURPOSE: Angiomyolipomas are rare benign renal tumors which occasionally require intervention.
  • Preservation of renal function is essential when treating renal angiomyolipoma in patients with multiple or bilateral lesions.
  • We report on the first series of patients with renal angiomyolipoma treated with laparoscopic cryoablation.
  • MATERIALS AND METHODS: Seven patients with pathologically confirmed renal angiomyolipoma underwent laparoscopic cryoablation.
  • Six patients were female, and 2 patients had associated tuberous sclerosis and multiple bilateral angiomyolipoma.
  • Renal function was preserved, with mean preoperative and postoperative creatinine 0.83 (range 0.6 to 1.6) and 0.91 (range 0.7 to 1.8), respectively.
  • CONCLUSIONS: Laparoscopic cryoablation is a safe and feasible minimally invasive, nephron sparing alternative for the treatment of angiomyolipoma.
  • [MeSH-major] Angiomyolipoma / surgery. Cryosurgery. Kidney Neoplasms / surgery. Laparoscopy

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  • (PMID = 16952669.001).
  • [ISSN] 0022-5347
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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70. Schade GR, Gofrit ON, Zorn KC: Renal angiomyolipoma with intravascular extension into the inferior vena cava: a case report and review of the literature. Can J Urol; 2008 Apr;15(2):4012-5
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  • [Title] Renal angiomyolipoma with intravascular extension into the inferior vena cava: a case report and review of the literature.
  • Imaging studies demonstrated numerous bilateral renal angiomyolipomas (AML), the largest located within the right upper pole, extending into the venous system to the level of the infra-hepatic inferior vena cava (IVC).
  • We present a case report and a description of the surgical management, and provide a review of the literature concerning this rare finding.
  • [MeSH-major] Angiomyolipoma / pathology. Kidney Neoplasms / pathology. Vascular Neoplasms / pathology. Vena Cava, Inferior / pathology

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  • (PMID = 18405452.001).
  • [ISSN] 1195-9479
  • [Journal-full-title] The Canadian journal of urology
  • [ISO-abbreviation] Can J Urol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Canada
  • [Number-of-references] 17
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71. Makino E, Yamada J, Tada J, Arata J, Iwatsuki K: Cutaneous angiolipoleiomyoma. J Am Acad Dermatol; 2006 Jan;54(1):167-71
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  • These histologic findings were consistent with those of angiomyolipoma, which commonly occurs in the kidney.
  • Cutaneous angiomyolipoma, which is also known as cutaneous angiolipoleiomyoma, is a rare benign mesenchymal tumor.
  • We point out the differences between the cutaneous and renal forms of angiomyolipoma, and conclude that the cutaneous lesion is distinct from a renal lesion in several aspects, including tuberous sclerosis complex association and immunoreactivity to both HMB-45 and MART-1.
  • [MeSH-major] Angiomyolipoma / diagnosis. Buttocks. Skin Neoplasms / diagnosis

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  • (PMID = 16384779.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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72. Okoń K: Pathology of renal tumors in adults. Molecular biology, histopathological diagnosis and prognosis. Pol J Pathol; 2008;59(3):129-76
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  • [Title] Pathology of renal tumors in adults. Molecular biology, histopathological diagnosis and prognosis.
  • Malignant renal tumors constitute 3% of human cancers, although their frequency differs greatly in various areas.
  • Since the fifties, the incidence of renal cancers has been increasing, but at the some time the prognosis has been improving.
  • In particular, in the last years, several new treatment modalities have been introduced, relying on the understanding of renal cancer biology.
  • The identified etiological factors include smoking, increased body mass, dietary factors and chronic renal disease.
  • There are several renal tumor types differing in morphology, molecular genetics and biology.
  • Differential diagnosis of these tumors is particularly difficult and may require extensive immunohistochemical and molecular studies.
  • Some renal tumors have been described or recognized only relatively recently; these newer entities include multilocular cystic clear cell carcinoma, spindle cell papillary mucinous carcinoma, tubulocystic carcinoma, renal epithelial and stromal tumor, epithelioid and oncocytic angiomyolipoma.
  • The improved prognosis in renal cancer depends on earlier detection, but also on refinement of therapeutic methods.
  • Renal carcinoma is notorious for its low sensitivity to chemotherapy and radiotherapy.
  • With this progress, perfect understanding of renal tumor biology and exact histological diagnosis have become of prime practical importance.
  • [MeSH-major] Kidney Neoplasms


73. Morbini P, Guddo F, Contini P, Luisetti M, Schiavina M, Zompatori M: Rare diffuse diseases of the lung. Pulmonary alveolar proteinosis, lymphangioleiomyomatosis, amyloidosis. Pathologica; 2010 Dec;102(6):547-56
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  • LAM is characterized by cystic lung degeneration and interstitial proliferation of LAM cells, which express both melanocyte and smooth muscle cell markers, has a typical cystic pattern on CT scan, can be associated clinically with abdominal angiomyolipomas and limphangioleiomyomas, and occurs in female patients, either in isolation or as a manifestation of tuberous sclerosis.
  • Sex hormone manipulation is the therapy of choice in this otherwise progressive disease.
  • Nodular amyloid deposits, in contrast, are not associated with systemic lung disease, and present instrumentally as a coin lesion or lung mass.
  • Isolated tracheobronchial amyloidosis is another rare form that is not related to systemic disease.
  • In all conditions, amyloid has a typical waxy, amorphous, slightly eosinophilic stain, stains red with Congo red and presents a characteristic apple-green birefringence under polarized light, which is essential for diagnosis.
  • [MeSH-major] Amyloidosis / diagnosis. Lung / pathology. Pulmonary Alveolar Proteinosis / diagnosis. Rare Diseases / diagnosis
  • [MeSH-minor] Female. Humans. Lung Diseases / congenital. Lung Diseases / diagnosis. Lung Diseases / radiography. Lung Diseases / therapy. Lymphangiectasis / congenital. Lymphangiectasis / diagnosis. Lymphangiectasis / radiography. Lymphangiectasis / therapy


74. Littrup PJ, Ahmed A, Aoun HD, Noujaim DL, Harb T, Nakat S, Abdallah K, Adam BA, Venkatramanamoorthy R, Sakr W, Pontes JE, Heilbrun LK: CT-guided percutaneous cryotherapy of renal masses. J Vasc Interv Radiol; 2007 Mar;18(3):383-92
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  • [Title] CT-guided percutaneous cryotherapy of renal masses.
  • PURPOSE: To assess the results of initial and current techniques for percutaneous renal cryotherapy, including long-term imaging outcomes.
  • These 49 masses included 36 primary renal cell carcinomas (RCCs), 3 oncocytomas, 1 angiomyolipoma, 6 renal inflammatory lesions, 2 benign parenchymal changes, and 1 colon cancer metastasis.
  • CONCLUSIONS: Percutaneous renal cryotherapy is a well-tolerated outpatient procedure that allows safe, CT monitoring of ice formation beyond visible tumor margins.
  • [MeSH-major] Cryosurgery / methods. Kidney Neoplasms / radiography. Kidney Neoplasms / surgery. Radiography, Interventional / methods. Tomography, X-Ray Computed / methods

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  • (PMID = 17377184.001).
  • [ISSN] 1535-7732
  • [Journal-full-title] Journal of vascular and interventional radiology : JVIR
  • [ISO-abbreviation] J Vasc Interv Radiol
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA-22453
  • [Publication-type] Clinical Trial; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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75. Spie R, Devevey JM, Ponnelle T, Michel F: [Angiomyolipoma with epithelioid contingent mimicking renal cell carcinoma]. Prog Urol; 2005 Apr;15(2):322-5; discussion 325
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  • [Title] [Angiomyolipoma with epithelioid contingent mimicking renal cell carcinoma].
  • [Transliterated title] Angiomyolipome à composante épithélioïde mimant un adénocarcinome rénal.
  • The authors report the case of a patient followed for renal angiomyolipoma.
  • On CT surveillance, this lesion developed features of a malignant tumour with loss of the fatty component and the patient was treated by nephrectomy.
  • Histological examination demonstrated renal angiomyolipoma with an epithelioid contingent.
  • [MeSH-major] Angiomyolipoma / pathology. Carcinoma, Renal Cell / pathology. Kidney Neoplasms / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans

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  • (PMID = 15999618.001).
  • [ISSN] 1166-7087
  • [Journal-full-title] Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
  • [ISO-abbreviation] Prog. Urol.
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 25
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76. Sun H, Xue HD, Liu W, Wang Y, Zhao WM, Jin ZY: [Perfusion characteristics of renal mass with 64-slice spiral computed tomography]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao; 2008 Dec;30(6):680-5
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  • [Title] [Perfusion characteristics of renal mass with 64-slice spiral computed tomography].
  • OBJECTIVE: To investigate the perfusion characteristics of renal mass parenchyma on 64-slice spiral computed tomography (CT).
  • METHODS: Totally 91 patients with renal mass were enrolled.
  • Sixty-four slice spiral CT was used for renal perfusion scan that began with a contrast bolus injection of 50 ml (370 mgI/ml) at a rate of 5 ml/s.
  • Perfusion characteristics, including blood flow (BF), blood volume (BV), and permeability (PM) of renal mass parenchyma and renal cortex in affected and normal kidneys were calculated from Siemens Body PCT (VB20B) software, and the perfusion characteristics among renal mass parenchyma and renal cortex in affected and normal kidneys were compared.
  • RESULTS: Renal clear cell carcinoma (RC-CC), renal pelvic transitional cell carcinoma (RPTCC), and renal angiomyolipoma (RAML) was pathologically confirmed in 40, 21, and 16 patients, respectively, while the remaining 14 patients were diagnosed as with renal simple cyst (RSC).
  • 1) between mass parenchyma and renal cortex in affected kidney, while there were no significant differences (P > 0.
  • 5) in perfusion characteristics between renal cortex in affected and normal kidneys.
  • Aslo, the perfusion characteristics were significantly different between parenchyma D in any two kinds of renal masses (P <0 .
  • C ONCLUSIONS: fDif-rent pathological types of renal mass have different perfusion characteristics.
  • Perfusion imaging with multislice CT is potentially useful in the differential diagnosis of renal mass.
  • [MeSH-major] Kidney Neoplasms / diagnosis. Kidney Neoplasms / radionuclide imaging

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  • (PMID = 19180916.001).
  • [ISSN] 1000-503X
  • [Journal-full-title] Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
  • [ISO-abbreviation] Zhongguo Yi Xue Ke Xue Yuan Xue Bao
  • [Language] chi
  • [Publication-type] Clinical Trial; English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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77. Prevoo W, van den Bosch MA, Horenblas S: Radiofrequency ablation for treatment of sporadic angiomyolipoma. Urology; 2008 Jul;72(1):188-91
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  • [Title] Radiofrequency ablation for treatment of sporadic angiomyolipoma.
  • INTRODUCTION: Symptomatic angiomyolipoma (AML) and asymptomatic AML larger than 4 cm in size are usually treated with nephron-sparing surgery or arterial embolization.
  • We used another technique, that is, radiofrequency ablation (RFA), for treatment of a sporadic AML in a patient with a solitary kidney, in whom maximal sparing of normal renal tissue was required.
  • TECHNICAL CONSIDERATIONS: Contrast-enhanced computed tomography (CT) showed an enhancing well-defined mainly lipomatous tumor, with a maximum diameter of 4.5 cm in the upper pole of the left kidney.
  • Diagnosis of AML was confirmed with fine-needle aspiration biopsy.
  • RFA was performed with a RF 3000 system, consisting of a generator that supplied up to 200W of power, connected to a 15-gauge LeVeen multipolar array electrode that was placed under CT-guidance centrally in the AML.
  • During follow-up (12 months) function of the solitary kidney of the patient was preserved and patient did not have any AML-related symptoms develop.
  • CONCLUSIONS: CT-guided RFA is a minimally invasive ablation procedure that allowed successful treatment of a sporadic AML in a patient with a solitary kidney.
  • [MeSH-major] Angiomyolipoma / surgery. Catheter Ablation. Kidney Neoplasms / surgery
  • [MeSH-minor] Aged. Humans. Kidney / abnormalities. Kidney / radiography. Male. Tomography, X-Ray Computed

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  • (PMID = 18455777.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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78. Hao LW, Lin CM, Tsai SH: Spontaneous hemorrhagic angiomyolipoma present with massive hematuria leading to urgent nephrectomy. Am J Emerg Med; 2008 Feb;26(2):249.e3-5
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  • [Title] Spontaneous hemorrhagic angiomyolipoma present with massive hematuria leading to urgent nephrectomy.
  • An immediate surgery is sometimes required for the hemorrhagic uropathy of renal angiomyolipoma.
  • Abdominal and pelvic computed tomographic scans showed a 3 x 5-cm, fat-containing tumor at the left lower pole of the kidney and a bleeding and perirenal hematoma in the left perirenal space.
  • An urgent left nephrectomy was lifesaving for the postoperative finding of renal angiomyolipoma.
  • [MeSH-major] Angiomyolipoma / surgery. Hematuria / etiology. Kidney Neoplasms / surgery. Nephrectomy

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  • (PMID = 18272126.001).
  • [ISSN] 1532-8171
  • [Journal-full-title] The American journal of emergency medicine
  • [ISO-abbreviation] Am J Emerg Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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79. Khalbuss WE, Fischer G, Bazooband A: Imprint cytology of epithelioid hepatic angiomyolipoma: mimicry of hepatocellular carcinoma. Acta Cytol; 2007 Jul-Aug;51(4):670-2
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  • [Title] Imprint cytology of epithelioid hepatic angiomyolipoma: mimicry of hepatocellular carcinoma.
  • [MeSH-major] Angiomyolipoma / pathology. Carcinoma, Hepatocellular / pathology. Epithelioid Cells / pathology. Liver Neoplasms / pathology. Molecular Mimicry

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  • (PMID = 17718152.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Letter
  • [Publication-country] United States
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80. Park BK: Comments on "Distribution of renal tumor growth rates determined by using serial volumetric CT measurements". Radiology; 2009 Jul;252(1):314; author reply 314-5
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  • [Title] Comments on "Distribution of renal tumor growth rates determined by using serial volumetric CT measurements".
  • [MeSH-major] Cone-Beam Computed Tomography / methods. Kidney Cortex / radiography. Kidney Neoplasms / radiography
  • [MeSH-minor] Adenoma, Oxyphilic / pathology. Adenoma, Oxyphilic / radiography. Adenoma, Oxyphilic / surgery. Adult. Aged. Aged, 80 and over. Angiomyolipoma / pathology. Angiomyolipoma / radiography. Angiomyolipoma / surgery. Carcinoma, Papillary / pathology. Carcinoma, Papillary / radiography. Carcinoma, Papillary / surgery. Carcinoma, Renal Cell / pathology. Carcinoma, Renal Cell / radiography. Carcinoma, Renal Cell / surgery. Disease Progression. Female. Humans. Male. Mathematical Computing. Middle Aged. Neoplasm Staging

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  • [CommentOn] Radiology. 2009 Jan;250(1):137-44 [19092093.001]
  • (PMID = 19561267.001).
  • [ISSN] 1527-1315
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
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81. Urban T: [Pulmonary lymphangioleiomyomatosis with or without tuberous sclerosis]. Rev Mal Respir; 2007 Jun;24(6):725-40
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  • INTRODUCTION: Pulmonary lymphangioleiomyomatosis (LAM) is a rare disease affecting young women and presenting with recurrent pneumothorax.
  • BACKGROUND: Other lesions such as chylothorax or renal angiomyolipoma may suggest the diagnosis.
  • Pulmonary function tests reveal bronchial obstruction and over-inflation with a reduced DLCO being the earliest abnormality.
  • In the absence of a controlled clinical trial hormone therapy has not been shown to be effective.
  • [MeSH-major] Lung Neoplasms / diagnosis. Lymphangioleiomyomatosis / diagnosis. Tuberous Sclerosis / complications
  • [MeSH-minor] Disease Progression. Female. Genes, Tumor Suppressor. Humans. Lung Transplantation. Respiratory Function Tests. Respiratory Insufficiency / etiology. Tumor Suppressor Proteins / genetics

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  • (PMID = 17632432.001).
  • [ISSN] 0761-8425
  • [Journal-full-title] Revue des maladies respiratoires
  • [ISO-abbreviation] Rev Mal Respir
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Tumor Suppressor Proteins; 0 / tuberous sclerosis complex 1 protein; 4JG2LF96VF / tuberous sclerosis complex 2 protein
  • [Number-of-references] 147
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82. Habib SL: Molecular mechanism of regulation of OGG1: tuberin deficiency results in cytoplasmic redistribution of transcriptional factor NF-YA. J Mol Signal; 2009;4:8
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  • TSC-2 gene encodes tuberin, a protein involved in the pathogenesis of kidney tumors, both angiomyolipomas and renal cell carcinomas.
  • In addition, tuberin haploinsufficiency is associated with the loss of OGG1 and accumulation of 8-oxodG in rat kidney tumor.
  • Deficiency in tuberin results in decreased OGG1 and NF-YA protein expression and increased 8-oxodG in kidney tumor from TSC patients.
  • The deficiency of tuberin was associated with a significant decrease in NF-YA and loss of OGG1 in kidney tumors of Eker rat.
  • Downregulation of tuberin by siRNA resulted in a marked decrease in NF-YA and OGG1 protein expression in human renal epithelial cells.
  • This mechanism may be important in the pathogenesis of kidney tumors in patients with TSC disease.

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  • (PMID = 20040097.001).
  • [ISSN] 1750-2187
  • [Journal-full-title] Journal of molecular signaling
  • [ISO-abbreviation] J Mol Signal
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2807420
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83. Bishay VL, Crino PB, Wein AJ, Malkowicz SB, Trerotola SO, Soulen MC, Stavropoulos SW: Embolization of giant renal angiomyolipomas: technique and results. J Vasc Interv Radiol; 2010 Jan;21(1):67-72
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  • [Title] Embolization of giant renal angiomyolipomas: technique and results.
  • PURPOSE: To evaluate the efficacy and safety of prophylactic embolization of angiomyolipomas (AMLs) larger than 10 cm.
  • CONCLUSIONS: Embolization of giant renal AMLs to decrease the risk of bleeding can be done safely without loss of renal function.
  • Although recurrence was infrequent, additional treatment may be necessary and giant renal AMLs should be followed up with serial imaging studies.
  • [MeSH-major] Angiomyolipoma / therapy. Antineoplastic Agents / therapeutic use. Ethanol / therapeutic use. Ethiodized Oil / therapeutic use. Kidney Neoplasms / therapy

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  • (PMID = 20123192.001).
  • [ISSN] 1535-7732
  • [Journal-full-title] Journal of vascular and interventional radiology : JVIR
  • [ISO-abbreviation] J Vasc Interv Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Radiopharmaceuticals; 3K9958V90M / Ethanol; 8008-53-5 / Ethiodized Oil
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84. Huo L, Sugimura J, Tretiakova MS, Patton KT, Gupta R, Popov B, Laskin WB, Yeldandi A, Teh BT, Yang XJ: C-kit expression in renal oncocytomas and chromophobe renal cell carcinomas. Hum Pathol; 2005 Mar;36(3):262-8
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  • [Title] C-kit expression in renal oncocytomas and chromophobe renal cell carcinomas.
  • Recently, KIT has been reported to be a marker for chromophobe renal cell carcinoma (RCC) and renal angiomyolipoma.
  • However, expression of this molecule has not been adequately studied in other renal tumors, particularly oncocytoma, which may morphologically resemble chromophobe RCC.
  • In this study, we analyzed c- kit messenger RNA (mRNA) levels in 17 chromophobe RCCs and 20 renal oncocytomas obtained from complementary DNA (cDNA) microarrays.
  • Furthermore, comprehensive immunohistochemical analysis of KIT protein using a monoclonal antibody was performed in 226 renal tumors including chromophobe RCC (n=40), oncocytoma (n=41), clear-cell RCC (n=40), renal angiomyolipoma (n=29), and papillary RCC (n=21) on tissue microarrays (TMAs) and was compared with immunostaining results from 25 chromophobe RCCs and 30 oncocytomas using standard sections.
  • The average increase of mRNA compared with normal kidney tissue was 7.4-fold for chromophobe RCCs and 7.4-fold for oncocytomas.
  • Immunohistochemical expression of KIT was found in most chromophobe RCCs (95% in TMAs and 96% in conventional sections) and oncocytomas (88% in TMAs and 100% in conventional sections) but was infrequently observed in renal angiomyolipomas (17%), papillary RCCs (5%), and clear-cell RCCs (3%).
  • Furthermore, the average KIT immunoreactivity in TMAs was stronger in chromophobe RCC (1.93) and oncocytoma (2.07) than in other subtypes of renal tumors tested, including angiomyolipomas (0.17), papillary RCCs (0.05), and clear-cell RCCs (0.03).
  • In contrast, immunohistochemical expression of KIT was not detected in most other types of renal cell tumors evaluated.
  • The differential expression of c- kit in these renal tumors may have diagnostic and therapeutic implications.
  • [MeSH-major] Adenoma, Oxyphilic / genetics. Carcinoma, Renal Cell / genetics. Gene Expression. Kidney Neoplasms / genetics. Proto-Oncogene Proteins c-kit / genetics. RNA, Messenger / analysis

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  • (PMID = 15791570.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Messenger; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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86. Painuly GP, Goyal S, Nautiyal S: Giant renal angiomyolipoma. BMJ Case Rep; 2009;2009
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  • [Title] Giant renal angiomyolipoma.
  • Ultrasound revealed a large retroperitoneal tumour with fatty elements, arising from the right kidney.
  • Findings of the computed tomography scan were typical for renal angiomyolipoma.

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  • (PMID = 22171231.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3027913
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87. Assefa G, Alemie B: Tuberous sclerosis complex (TSC) and Klippel-Trenaunay-Weber (KTW) syndromes association of two complete phakomatoses in a single individual. Ethiop Med J; 2010 Oct;48(4):315-20
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  • Tuberous sclerosis or tuberous sclerosis complex (TSC) and Klippel-Trenaunay-Weber (KTW) syndromes are phakomatoses which are believed to be inherited separately were associated in a 21 years old female, with no family history of similar illness presented with facial rash of reddish spots or bumps, facial angiofibroma (adenoma cebaceum), which appeared on the nose and cheeks in a butterfly distribution, and sub ependymal calcific nodules on brain CT, and multiple liver, pancreas hamartomas and multiple angiomyolipomas and cysts of both kidney on ultrasound, which is consistent with a sporadic TSC, in addition, the diagnostic triad of KTW involved the left upper limb : cutaneous naevi a vascular anomaly, soft tissue and osteohypertrophy.

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  • (PMID = 21280434.001).
  • [ISSN] 0014-1755
  • [Journal-full-title] Ethiopian medical journal
  • [ISO-abbreviation] Ethiop. Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Ethiopia
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88. Ramuz O, Lelong B, Giovannini M, Delpero JR, Rochaix P, Xerri L, Hassoun J, Flejou JF, Monges G: "Sugar" tumor of the pancreas: a rare entity that is diagnosable on preoperative fine-needle biopsies. Virchows Arch; 2005 May;446(5):555-9
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  • This ST was incidentally discovered in a 31-year-old woman using computed tomography scan (CT scan) for work-up of a hepatic focal nodular hyperplasia.
  • Pathological examination of EUS-guided fine-needle aspiration biopsies could not confirm this diagnosis.
  • This observation highlights that STs should be considered in preoperative differential diagnosis of pancreas tumors, since they may be treated by limited surgical resection.
  • [MeSH-minor] Adult. Angiomyolipoma / chemistry. Angiomyolipoma / pathology. Angiomyolipoma / surgery. Antigens, Neoplasm. Diagnosis, Differential. Female. Focal Nodular Hyperplasia / complications. Humans. Laparoscopy. Melanoma-Specific Antigens. Neoplasm Proteins / analysis. Pancreatectomy. Tomography, X-Ray Computed

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  • [Cites] Pathology. 1994 Jul;26(3):230-6 [7991275.001]
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  • (PMID = 15821930.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins
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89. Sibony M, Vieillefond A: [Non clear cell renal cell carcinoma. 2008 update in renal tumor pathology]. Ann Pathol; 2008 Oct;28(5):381-401
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Non clear cell renal cell carcinoma. 2008 update in renal tumor pathology].
  • Non clear cell renal cell carcinomas represent almost 20% of all renal neoplasms.
  • Since molecular techniques are expensive, diagnosis still relies on morphological and immuno-histochemical criteria detailed hereby.
  • Papillary renal cell carcinomas are the most important group and its classification is more and more complex.
  • It encompasses low-grade papillary carcinomas (type 1 papillary renal cell carcinoma, oncocytic papillary renal cell carcinoma) and high-grade papillary carcinomas (type 2 papillary renal cell carcinoma, juvenile papillary carcinoma corresponding to renal carcinoma associated with Xp11.2 translocations and unclassified carcinomas).
  • The so-called carcinoma of collecting ducts of Bellini and renal medullary carcinoma should be considered as intrarenal urothelial carcinoma or as high-grade papillary or unclassified carcinoma.
  • Sarcomatoid carcinoma derives from morphological progression of any type of renal cell carcinoma.
  • The group of oncocytomas/chromophobe renal cell carcinomas can be considered as a spectrum from benign (oncocytoma) to malignant neoplasm (chromophobe renal cell carcinoma).
  • Angiomyolipoma is usually a benign mesenchymatous neoplasm, that can be sporadic or familial (tuberous sclerosis).
  • In the latter situation, some cases of epithelioid angiomyolipoma (potentially malignant) have been described.
  • Renal epithelial and stromal tumors (REST) is a new concept gathering two benign mixed mesenchymal and epithelial tumors: cystic nephroma and mixed epithelial and stromal tumors (MEST).
  • [MeSH-major] Adenocarcinoma, Clear Cell / pathology. Carcinoma, Renal Cell / pathology. Kidney Neoplasms / pathology
  • [MeSH-minor] Adenoma, Oxyphilic / classification. Adenoma, Oxyphilic / genetics. Adenoma, Oxyphilic / pathology. Carcinoma / classification. Carcinoma / genetics. Carcinoma / pathology. Chromosome Mapping. Chromosomes, Human. Humans. Immunohistochemistry. Kidney / pathology. Kidney Tubules, Collecting / pathology. Necrosis


90. Yen YH, Wang JH, Lu SN, Changchien CS: Contrast-enhanced ultrasonography in hepatic angiomyolipoma. J Ultrasound Med; 2005 Jun;24(6):855-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Contrast-enhanced ultrasonography in hepatic angiomyolipoma.
  • [MeSH-major] Angiomyolipoma / ultrasonography. Liver Neoplasms / ultrasonography. Ultrasonography, Doppler / methods
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Image Enhancement. Male. Tomography, X-Ray Computed

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  • (PMID = 15914690.001).
  • [ISSN] 0278-4297
  • [Journal-full-title] Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
  • [ISO-abbreviation] J Ultrasound Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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91. Nakamura N, Kudo A, Ito K, Tanaka S, Arii S: A hepatic lipoma mimicking angiomyolipoma of the liver: report of a case. Surg Today; 2009;39(9):825-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A hepatic lipoma mimicking angiomyolipoma of the liver: report of a case.
  • Since the current knowledge of such tumors is based primarily on individual case reports and small case series, little is so far known about this disease.
  • This report presents a case of lipoma of the liver mimicking angiomyolipoma.
  • These were diagnosed to be either lipoma or angiomyolipoma of the liver.
  • Therefore, the final diagnosis was lipoma of the liver, which is an extremely rare benign liver tumor.
  • [MeSH-major] Angiomyolipoma / diagnosis. Lipoma / diagnosis. Liver Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male

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  • (PMID = 19779784.001).
  • [ISSN] 1436-2813
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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92. Iribarren Díaz M, Lojo Sánchez JL, Carracedo Iglesias R, de Castro Parga G, Díaz Cardamas P, Tardío Baiges A, Casal Nuñez E: [Hepatic angiomyolipoma: a challenging preoperative diagnosis]. Rev Esp Enferm Dig; 2008 Oct;100(10):661-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Hepatic angiomyolipoma: a challenging preoperative diagnosis].
  • [Transliterated title] Angiomiolipoma hepático: una entidad de difícil diagnóstico preoperatorio.
  • [MeSH-major] Angiomyolipoma / diagnosis. Liver Neoplasms / diagnosis

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  • (PMID = 19119797.001).
  • [ISSN] 1130-0108
  • [Journal-full-title] Revista española de enfermedades digestivas : organo oficial de la Sociedad Española de Patología Digestiva
  • [ISO-abbreviation] Rev Esp Enferm Dig
  • [Language] spa
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Spain
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93. Alatassi H, Sahoo S: Epithelioid angiomyolipoma of the liver with striking giant cell component: fine-needle aspiration biopsy findings of a rare neoplasm. Diagn Cytopathol; 2009 Mar;37(3):192-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epithelioid angiomyolipoma of the liver with striking giant cell component: fine-needle aspiration biopsy findings of a rare neoplasm.
  • Angiomyolipoma (AML) is a uncommon benign neoplasm of the liver with cyto- and histologic features similar to the more commonly encountered renal AML.
  • Here, we describe the cytologic findings of a unique case of epithelioid AML with numerous giant cells.
  • [MeSH-major] Angiomyolipoma / pathology. Carcinoma, Hepatocellular / pathology. Giant Cells / pathology. Liver Neoplasms / pathology
  • [MeSH-minor] Actins / metabolism. Antigens, Neoplasm / metabolism. Biopsy, Fine-Needle. Diagnosis, Differential. Female. Humans. Keratins / metabolism. Melanoma-Specific Antigens. Neoplasm Proteins / metabolism. S100 Proteins / metabolism. Young Adult

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  • (PMID = 19156824.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, Neoplasm; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins; 0 / S100 Proteins; 68238-35-7 / Keratins
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94. Kochhar R, Brown RK, Wong CO, Dunnick NR, Frey KA, Manoharan P: Role of FDG PET/CT in imaging of renal lesions. J Med Imaging Radiat Oncol; 2010 Aug;54(4):347-57
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Role of FDG PET/CT in imaging of renal lesions.
  • Focal incidental renal lesions are commonly encountered on positron emission tomography (PET)/computed tomography (CT) imaging.
  • However, the interpretation of renal lesions can be problematic if the imaging criteria of simple cysts are not met.
  • Limited literature exists on the characterisation of renal masses with metabolic imaging.
  • The purpose of this article is to focus on the imaging features of benign and malignant renal masses with PET/CT.
  • The lesions discussed include renal cyst, angiomyolipoma, oncocytoma, renal cell carcinoma, renal metastases and other infiltrating neoplastic processes affecting the kidney.
  • We emphasise the importance of viewing the CT component to identify the typical morphological features and discuss how to best use hybrid imaging for management of renal lesions.
  • Metabolic imaging has a promising role in the imaging of renal lesions and can help prevent unnecessary biopsies and ensure optimal management of suspicious lesions.
  • [MeSH-major] Carcinoma, Renal Cell / diagnosis. Fluorodeoxyglucose F18. Kidney Neoplasms / diagnosis. Positron-Emission Tomography / methods. Radiopharmaceuticals. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Adenoma, Oxyphilic / diagnosis. Angiomyolipoma / diagnosis. Cysts / diagnosis. Humans. Incidental Findings. Kidney / radiography. Kidney / radionuclide imaging. Kidney Diseases / diagnosis. Leukemia / diagnosis. Lymphoma / diagnosis

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  • (PMID = 20718915.001).
  • [ISSN] 1754-9485
  • [Journal-full-title] Journal of medical imaging and radiation oncology
  • [ISO-abbreviation] J Med Imaging Radiat Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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95. Cottin V, Archer F, Khouatra C, Lazor R, Cordier JF: [Lymphangioleiomyomatosis]. Presse Med; 2010 Jan;39(1):116-25
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Lymphangioleiomyomatosis is a rare pulmonary disease encountered almost exclusively in women of reproductive age.
  • Certainty of diagnosis requires a lung biopsy, but international criteria have been proposed for a diagnosis without such a biopsy.
  • International recommendations were recently issued for the diagnosis and treatment of lymphangioleiomyomatosis.
  • Treatment is principally symptomatic and relies on the management of bronchial obstruction by bronchodilators; of hypoxemia by oxygen therapy; of pleural complications by pleurodesis, most often surgical; and of renal angiomyolipomas by percutaneous embolization in cases of hemorrhagic risk.
  • [MeSH-major] Lung Neoplasms / diagnosis. Lymphangioleiomyomatosis / diagnosis
  • [MeSH-minor] Angiolipoma / therapy. Chylothorax / etiology. Chylothorax / therapy. Female. Genes, Tumor Suppressor. Humans. Kidney Neoplasms / therapy. Pneumothorax / etiology. Pneumothorax / therapy. Prognosis. Tuberous Sclerosis / diagnosis. Tumor Suppressor Proteins / genetics

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  • [Copyright] Copyright 2009 Elsevier Masson SAS. All rights reserved.
  • (PMID = 19944562.001).
  • [ISSN] 2213-0276
  • [Journal-full-title] Presse medicale (Paris, France : 1983)
  • [ISO-abbreviation] Presse Med
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Tumor Suppressor Proteins; 0 / tuberous sclerosis complex 1 protein; 4JG2LF96VF / tuberous sclerosis complex 2 protein
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96. Kim HJ, Yang I, Jung AY, Hwang JH, Shin MK: Angiomyxolipoma (vascular myxolipoma) of the knee in a 9-year-old boy. Pediatr Radiol; 2010 Dec;40 Suppl 1:S30-3
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  • Herein, we report a unique case of a 9-year-old boy presenting with a solitary painful mass on the right medial thigh and illustrate the imaging characteristics of this rare tumor.
  • [MeSH-major] Angiomyolipoma / diagnosis. Muscle Neoplasms / diagnosis

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  • [Cites] Am J Dermatopathol. 2004 Jun;26(3):222-4 [15166511.001]
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  • (PMID = 20665016.001).
  • [ISSN] 1432-1998
  • [Journal-full-title] Pediatric radiology
  • [ISO-abbreviation] Pediatr Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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97. Fine SW, Reuter VE, Epstein JI, Argani P: Angiomyolipoma with epithelial cysts (AMLEC): a distinct cystic variant of angiomyolipoma. Am J Surg Pathol; 2006 May;30(5):593-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiomyolipoma with epithelial cysts (AMLEC): a distinct cystic variant of angiomyolipoma.
  • Renal angiomyolipoma (AML) is typically a solid lesion, composed of varying amounts of adipose, vascular, and muscular tissue, lacking an epithelial component.
  • Although it is known that entrapped renal tubules may be observed in AML, presentation as a cystic mass has not been previously reported.
  • We report the clinicopathologic and immunohistochemical features of four cystic renal AML.
  • One of the four patients had known tuberous sclerosis, and this patient and 1 other presented with bilateral cystic renal lesions.
  • Whereas the cysts appear to arise primarily from entrapped collecting ducts, the peculiar subepithelial condensation of AML stromal cells, with morphologic and immunohistochemical features suggesting differentiation toward endometrial stroma, may represent epithelial-induced müllerian differentiation not previously reported in AML.
  • [MeSH-major] Angiomyolipoma / pathology. Kidney Diseases, Cystic / pathology. Kidney Neoplasms / pathology

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  • (PMID = 16699313.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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98. Takanami K, Kaneta T, Hitachi S, Yamada T, Ishida K, Rikiyama T, Katayose Y, Unno M, Yamada S, Takahashi S: F-18 FDG PET/CT findings in two patients with hepatic angiomyolipoma with and without intratumoral hemorrhage. Clin Nucl Med; 2010 Jan;35(1):18-21
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  • [Title] F-18 FDG PET/CT findings in two patients with hepatic angiomyolipoma with and without intratumoral hemorrhage.
  • Two female patients aged 62 and 74 years underwent F-18 FDG PET/CT for evaluation of a large hepatic tumor.
  • Subsequently, both patients underwent a partial hepatectomy which histopathologically revealed benign hepatic angiomyolipomas (AMLs).
  • [MeSH-major] Angiomyolipoma / diagnosis. Fluorodeoxyglucose F18. Hemorrhage / radionuclide imaging. Liver Neoplasms / diagnosis. Positron-Emission Tomography / methods. Tomography, X-Ray Computed / methods

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  • (PMID = 20026966.001).
  • [ISSN] 1536-0229
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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99. Svajdler M, Bohus P, Goc V, Tkácová V: [Perivascular epithelioid cell tumor (PEComa) of the liver: a case report and review of the literature]. Cesk Patol; 2007 Jan;43(1):18-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • By immunohistochemistry and genetics it belongs to the family of tumours which comprises angiomyolipoma, clear cell "sugar" tumor of lung, lymphangioleiomyomatosis and clear cell myomelanotic tumor of ligamentum falciforme/teres hepatis.
  • Histologically the tumor grew in expansive way, and was composed of clear and eosinophilic epithelioid cels, without vascular or lipomatous component characteristic of angiomyolipoma.
  • The main differential diagnosis of hepatic PEComa includes clear cell variant of liver cell adenoma and hepatocellular carcinoma, metastases of various clear cell carcinomas and metastasis of malignant melanoma.


100. Williams TR, Oakes MF: Metastatic breast carcinoma to renal angiomyolipomas in tuberous sclerosis. Urology; 2008 Feb;71(2):352.e5-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic breast carcinoma to renal angiomyolipomas in tuberous sclerosis.
  • Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disease manifesting as hamartomatous involvement of several organs, including brain, kidneys, skin, heart, lungs, and retina.
  • We report the first case of a patient with TSC, with large bilateral renal angiomyolipomas (AML), who developed multiple soft tissue masses within her primarily fatty AMLs, resulting from metastatic breast cancer.
  • [MeSH-major] Angiomyolipoma / complications. Angiomyolipoma / pathology. Breast Neoplasms / complications. Breast Neoplasms / pathology. Kidney Neoplasms / complications. Kidney Neoplasms / secondary. Tuberous Sclerosis / complications






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