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Items 1 to 25 of about 25
1. Rao S, Rajkumar A, Kuruvilla S: Angiomatous meningioma: a diagnostic dilemma. Indian J Pathol Microbiol; 2008 Jan-Mar;51(1):53-5
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  • [Title] Angiomatous meningioma: a diagnostic dilemma.
  • Angiomatous meningioma accounts for 2.1% of all meningiomas.
  • It has features of a typical benign meningioma with many small or large vascular channels which may predominate over its meningothelial elements.
  • We present here a series of three cases of angiomatous meningioma, which posed diagnostic difficulty to clinicians, radiologists, and pathologists.
  • We present series of three cases to highlight the histomorphological features of this uncommon variant of meningioma that could help in distinguishing it from hemangioblastoma and hemangiopericytoma.
  • [MeSH-major] Meningeal Neoplasms / pathology. Meningioma / diagnosis

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  • (PMID = 18417856.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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2. Deb P, Sahni H, Bhatoe HS: Cystic angiomatous meningioma in the cerebellopontine angle mimicking hemangioblastoma. J Cancer Res Ther; 2010 Oct-Dec;6(4):560-3
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  • [Title] Cystic angiomatous meningioma in the cerebellopontine angle mimicking hemangioblastoma.
  • We hereby report an extremely unusual case of cystic angiomatous meningioma in the CPA region in a 58-year-old male patient.
  • Histopathology revealed an angiomatous meningioma with predominant microvascular component and extensive cystic changes.
  • [MeSH-major] Cerebellopontine Angle / pathology. Hemangioblastoma / pathology. Meningioma / pathology

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  • (PMID = 21358102.001).
  • [ISSN] 1998-4138
  • [Journal-full-title] Journal of cancer research and therapeutics
  • [ISO-abbreviation] J Cancer Res Ther
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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3. Rao S, Rajkumar A, Ehtesham MD, Duvuru P: Challenges in neurosurgical intraoperative consultation. Neurol India; 2009 Jul-Aug;57(4):464-8
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  • RESULTS AND OBSERVATIONS: A total of 6% of the cases were found to be discordant; these included angiomatous meningioma, Non-Hodgkins lymphoma, metastatic renal cell carcinoma, cerebellopontine angle fibrous meningioma, and craniopharyngioma.

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  • (PMID = 19770549.001).
  • [ISSN] 0028-3886
  • [Journal-full-title] Neurology India
  • [ISO-abbreviation] Neurol India
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
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4. Kimura H, Takeuchi H, Koshimoto Y, Arishima H, Uematsu H, Kawamura Y, Kubota T, Itoh H: Perfusion imaging of meningioma by using continuous arterial spin-labeling: comparison with dynamic susceptibility-weighted contrast-enhanced MR images and histopathologic features. AJNR Am J Neuroradiol; 2006 Jan;27(1):85-93
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  • [Title] Perfusion imaging of meningioma by using continuous arterial spin-labeling: comparison with dynamic susceptibility-weighted contrast-enhanced MR images and histopathologic features.
  • PURPOSE: The goal of the present study was to determine the utility of continuous arterial spin labeling (CASL) for characterization of meningioma by MR perfusion imaging and to compare these results with those obtained from the T2 dynamic susceptibility contrast (T2DSC) method and from histopathologic examination.
  • METHODS: Twenty-one cases of meningiomas were examined at 1.5T.
  • Perfusion values were the greatest for angiomatous meningioma and lowest for fibrous meningioma when using either perfusion method.
  • CONCLUSIONS: CASL and T2DSC perfusion methods are comparable in the characterization of meningiomas.
  • [MeSH-major] Brain / pathology. Cerebrovascular Circulation. Contrast Media. Magnetic Resonance Angiography. Meningeal Neoplasms / diagnosis. Meningioma / diagnosis. Spin Labels

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  • (PMID = 16418363.001).
  • [ISSN] 0195-6108
  • [Journal-full-title] AJNR. American journal of neuroradiology
  • [ISO-abbreviation] AJNR Am J Neuroradiol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Spin Labels
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5. Sangermani R, Arienta C, Tonella M, Scalfaro C, Podestà AF: [Angiomatous meningioma and epilepsy in a 2.6-years-old girl]. Pediatr Med Chir; 2005 May-Aug;27(3-4):108-11
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  • [Title] [Angiomatous meningioma and epilepsy in a 2.6-years-old girl].
  • [MeSH-major] Epilepsy, Complex Partial / etiology. Meningeal Neoplasms / complications. Meningioma / complications. Temporal Lobe

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  • (PMID = 16910461.001).
  • [ISSN] 0391-5387
  • [Journal-full-title] La Pediatria medica e chirurgica : Medical and surgical pediatrics
  • [ISO-abbreviation] Pediatr Med Chir
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
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6. Taraszewska A, Matyja E: Lectin binding pattern in meningiomas of various histological subtypes. Folia Neuropathol; 2007;45(1):9-18

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  • [Title] Lectin binding pattern in meningiomas of various histological subtypes.
  • It has been reported that meningiomas express variability in glycosylation properties; however only limited meningioma subtypes have been studied with lectins histochemistry.
  • The aim of this study was to compare the binding pattern of biotinylated lectins in seven subtypes of histologically benign intracranial meningiomas (meningothelial, transitional, fibroblastic, psammomatous, secretory, microcystic and angiomatous types).
  • The study was performed on biopsy material of 30 cases of meningiomas with different lectins: Peanut agglutinin (PNA), Soybean agglutinin (SBA), Dolichos biflorus agglutinin (DBA), Wheat germ agglutinin (WGA), Cocanavalin A (Con A) and Ulex europaeus agglutinin 1 (UEA-1).
  • The expression of lectin-binding glycoconjugates exhibited differences between certain subtypes of meningiomas.
  • WGA with affinity for GlcNAc and neuraminic acid labelled the cells of all meningiomas but most intensely those of fibroblastic type.
  • Enhanced PNA reactivity reflected mainly cytoarchitectural pattern of tumour growth, such as syncytial lobules, whorled formations or trabecular arrangements of meningioma cells.
  • The secretory meningiomas exhibited strong and heterogeneous lectins reactivity within pseudopsammoma bodies whereas the neoplastic cells were only occasionally stained.
  • The selective reactivity of UEA-1 with endothelial cells of blood vessels resulted in a specific visualisation of the vascular network in all histological subtypes of meningiomas.
  • These results documented the heterogeneous glycosylation pattern in different subtypes of meningiomas and indicate the usefulness of lectins in the evaluation of pluripotential differentiation of meningioma cells.

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  • (PMID = 17357005.001).
  • [ISSN] 1641-4640
  • [Journal-full-title] Folia neuropathologica
  • [ISO-abbreviation] Folia Neuropathol
  • [Language] ENG
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Lectins
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7. Sturges BK, Dickinson PJ, Bollen AW, Koblik PD, Kass PH, Kortz GD, Vernau KM, Knipe MF, Lecouteur RA, Higgins RJ: Magnetic resonance imaging and histological classification of intracranial meningiomas in 112 dogs. J Vet Intern Med; 2008 May-Jun;22(3):586-95
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  • [Title] Magnetic resonance imaging and histological classification of intracranial meningiomas in 112 dogs.
  • BACKGROUND: Intracranial meningiomas are the most common primary brain tumors in dogs.
  • Classification of meningiomas by tumor grade and subtype has not been reported, and the value of magnetic resonance imaging (MRI) characteristics for predicting tumor subtype and grade has not been investigated.
  • HYPOTHESIS: Canine intracranial meningiomas are a heterogenous group of tumors with differing histological subtypes and grades.
  • ANIMALS: One hundred and twelve dogs with a histological diagnosis of intracranial meningioma.
  • RESULTS: Meningiomas were overrepresented in the Golden Retriever and Boxer breeds with no sex predilection.
  • Grade I histological subtypes included meningothelial (43%), transitional (40%), microcystic (8%), psammomatous (6%), and angiomatous (3%).
  • CONCLUSIONS AND CLINICAL IMPORTANCE: Meningiomas in dogs differ from their counterparts in humans mainly in their higher incidence of atypical (Grade II) tumors observed.
  • MRI characteristics do not allow for prediction of meningioma subtype or grade, emphasizing the necessity of histopathology for antemortem diagnosis.
  • The higher incidence of atypical tumors in dogs may contribute to the poorer therapeutic response in dogs with meningiomas as compared with the response in humans with meningiomas.

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  • (PMID = 18466258.001).
  • [ISSN] 0891-6640
  • [Journal-full-title] Journal of veterinary internal medicine
  • [ISO-abbreviation] J. Vet. Intern. Med.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
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8. Cabada T, Caballero MC, Insausti I, Alvarez de Eulate N, Bacaicoa C, Zazpe I, Tuñón T: [The role of diffusion-weighted imaging in the evaluation of meningiomas: radio-pathologic correlation]. Radiologia; 2009 Jul-Aug;51(4):411-9

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  • [Title] [The role of diffusion-weighted imaging in the evaluation of meningiomas: radio-pathologic correlation].
  • [Transliterated title] Papel de la difusión en la evaluación de los meningiomas: correlación radiopatológica.
  • OBJECTIVE: To study the behavior of meningiomas in diffusion-weighted sequences and the correlation of these findings with the histological findings.
  • MATERIAL AND METHODS: We prospectively included all patients operated on for meningiomas at our hospital during two years.
  • We studied 30 meningiomas in 28 patients aged 31 to 85 years old.
  • RESULTS: Of the 30 meningiomas, 22 were World Health Organization (WHO) grade I and 8 were atypical or WHO grade II.
  • Two subtypes of typical meningiomas, secretory and angiomatous meningiomas, had the highest values in the ADC maps.
  • CONCLUSION: Meningiomas show moderately restricted diffusion.
  • [MeSH-major] Diffusion Magnetic Resonance Imaging. Meningeal Neoplasms / pathology. Meningeal Neoplasms / radiography. Meningioma / pathology. Meningioma / radiography

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  • (PMID = 19552929.001).
  • [ISSN] 0033-8338
  • [Journal-full-title] Radiología
  • [ISO-abbreviation] Radiologia
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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9. Gül S, Kalayci M, Edebali N, Yurdakan G, Açikgöz B: A multilevel thoracolumbar meningioma in a young woman. Acta Neurochir (Wien); 2008 Aug;150(8):843-4
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  • [Title] A multilevel thoracolumbar meningioma in a young woman.
  • Spinal meningiomas of five or more vertebral segment long are very rare and also less common in younger patients.
  • The histopathological diagnosis was angiomatous meningioma.
  • [MeSH-major] Meningeal Neoplasms / surgery. Meningioma / surgery. Spinal Cord Compression / surgery. Spinal Cord Neoplasms / surgery

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  • (PMID = 18548187.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Austria
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10. Oshita J, Sogabe T, Maeda H, Sato H, Sugiyama K, Kurisu K: [A case of multiple meningiomas: two lesions have different clinicopathological features, respectively]. No Shinkei Geka; 2007 Sep;35(9):929-34

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  • [Title] [A case of multiple meningiomas: two lesions have different clinicopathological features, respectively].
  • Computed tomographic (CT) scans and magnetic resonance (MR) imaging showed two meningiomas located at the bilateral frontal convex respectively.
  • Both tumors were microscopically diagnosed as angiomatous meningioma.
  • We suggest that pial-blood supply, adhesion to brain tissue and VEGF expression influence the development of meningioma-associated peritumoral edema.
  • [MeSH-major] Meningeal Neoplasms / pathology. Meningioma / pathology

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  • (PMID = 17867314.001).
  • [ISSN] 0301-2603
  • [Journal-full-title] No shinkei geka. Neurological surgery
  • [ISO-abbreviation] No Shinkei Geka
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Vascular Endothelial Growth Factor A
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12. El Husseini M, Ianovici N, Dumitrescu GF, Mihăilă D, Plămădeală P, Haba D, Indrei A: [Posterior fossa meningiomas--topographic and anatomopathologic aspects]. Rev Med Chir Soc Med Nat Iasi; 2010 Jul-Sep;114(3):777-83
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  • [Title] [Posterior fossa meningiomas--topographic and anatomopathologic aspects].
  • Meningiomas are the most frequent met intracranial tumors.
  • MATERIAL AND METHOD: Our study is focused on posterior fosa meningiomas, initially classified according to their origin based on IRM and surgical findings in order to identify correlations between demographic data, topographic tumor origin and anatomopathologic characteristics for each subgroup.
  • 35 posterior fosa meningioma patients that have been subject to neurosurgery in Iaşi "Prof.Dr. N.
  • Benign meningiomas (1st degree) represented the unique subtype in tumors located in cerebellum convexity and foramen magnum.
  • Other locations have different characteristic subtypes (fibrous vs. angiomatous meningioma).
  • [MeSH-major] Cranial Fossa, Posterior / pathology. Meningeal Neoplasms / diagnosis. Meningioma / diagnosis

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  • (PMID = 21243804.001).
  • [ISSN] 0048-7848
  • [Journal-full-title] Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i
  • [ISO-abbreviation] Rev Med Chir Soc Med Nat Iasi
  • [Language] rum
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Romania
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13. Takeuchi H, Hashimoto N, Kitai R, Kubota T: A report of supratentorial leptomeningeal hemangioblastoma and a literature review. Neuropathology; 2008 Feb;28(1):98-102
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  • Histologic examination revealed a hemangioblastoma with features resembling angiomatous meningioma.
  • Electron microscopic investigation is essential to differentiate between meningiomas and other leptomeningeal tumors.
  • [MeSH-minor] Diagnosis, Differential. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Male. Meningioma / pathology. Microscopy, Electron, Transmission. Middle Aged

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  • (PMID = 18181838.001).
  • [ISSN] 0919-6544
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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14. Chen ZC, Wang CP, Hsiao JK, Ko JY, Tseng HM, Yao YT: Angiomatous type of jugular foramen meningioma with neck extension: differential diagnosis from paraganglioma and schwannoma. Head Neck; 2007 Aug;29(8):793-8
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  • [Title] Angiomatous type of jugular foramen meningioma with neck extension: differential diagnosis from paraganglioma and schwannoma.
  • BACKGROUND: Meningiomas involving the jugular foramen and parapharyngeal space are extremely rare.
  • The patient was found to have the spreading, carpet-like, meningioma with extracranial extensions via jugular foramen to parapharyngeal space.
  • CONCLUSIONS: Accurate distinction between meningioma and glomus tumor or schwannoma is possible in most cases, with attention to fine radiologic detail.
  • [MeSH-major] Glomus Jugulare Tumor / diagnosis. Meningeal Neoplasms / diagnosis. Meningioma / diagnosis. Neurilemmoma / diagnosis. Paraganglioma / diagnosis

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  • (PMID = 17252587.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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15. Romeike BF, Joellenbeck B, Skalej M, Scherlach C, Kirches E, Mawrin C: Intraventricular meningioma with fatal haemorrhage: clinical and autopsy findings. Clin Neurol Neurosurg; 2007 Dec;109(10):884-7
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  • [Title] Intraventricular meningioma with fatal haemorrhage: clinical and autopsy findings.
  • Only a few cases of intraventricular meningioma have been reported and the association with intracranial haemorrhage is even rarer.
  • Here, we report a case of primary intraventricular meningioma with intraventricular haemorrhage in a 57-year-old woman.
  • At autopsy, the tumour was histologically diagnosed as a fibroblastic meningioma WHO-Grade I.
  • The source of haemorrhage was most likely the tumour itself as it contained focally rather large angiomatous and additionally small cavernous vessels and acute haemorrhage in various sections.
  • [MeSH-major] Cerebral Hemorrhage / pathology. Cerebral Ventricle Neoplasms / pathology. Meningeal Neoplasms / pathology. Meningioma / pathology

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  • (PMID = 17764829.001).
  • [ISSN] 0303-8467
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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16. Ohba S, Yoshida K, Hirose Y, Ikeda E, Kawase T: Meningioma of the cerebellopontine angle in identical twins: a case report. J Neurooncol; 2010 Jul;98(3):411-5
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  • [Title] Meningioma of the cerebellopontine angle in identical twins: a case report.
  • Meningiomas in identical twins are extremely rare.
  • To our knowledge, only one previous report of meningiomas in identical twins has been published.
  • We present identical twin sisters with meningiomas.
  • Histologically, both tumors were diagnosed as meningothelial meningiomas with an angiomatous component.
  • These results strongly suggest that genetic aberrations other than NF2 are associated with tumorigenesis in some types of sporadic meningiomas.
  • [MeSH-major] Cerebellar Diseases / pathology. Cerebellopontine Angle / pathology. Diseases in Twins. Meningeal Neoplasms / pathology. Meningioma / pathology

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  • (PMID = 20012670.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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17. Arai M, Kashihara K, Kaizaki Y: Enhancing gliotic cyst wall with microvascular proliferation adjacent to a meningioma. J Clin Neurosci; 2006 Jan;13(1):136-9
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  • [Title] Enhancing gliotic cyst wall with microvascular proliferation adjacent to a meningioma.
  • Cystic meningiomas are uncommon.
  • Histological analysis demonstrated a gliotic cyst wall with numerous microvascular proliferations (MVPs) adjacent to a mixed transitional and angiomatous/microcystic meningioma.
  • Immunoreactivity for tenascin-C was strongly observed within and around the vascular wall of MVPs and in gliotic tissue adjacent to the meningioma.
  • These changes are unusual in the peritumoral brain parenchyma of a slow-growing convexity meningioma and the MVPs may account for the atypical contrast enhancement of the cyst wall despite the absence of tumor cells.
  • [MeSH-major] Meningeal Neoplasms / pathology. Meningioma / pathology. Neovascularization, Pathologic

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  • (PMID = 16410217.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A
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18. Bhatoe HS, Singh P, Dutta V: Intraventricular meningiomas: a clinicopathological study and review. Neurosurg Focus; 2006;20(3):E9

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  • [Title] Intraventricular meningiomas: a clinicopathological study and review.
  • OBJECT: Intraventricular meningiomas are rare tumors.
  • METHODS: In this retrospective analysis, the authors describe the cases of 12 patients who had received a diagnosis of intraventricular meningioma and underwent surgery for the tumors.
  • Histopathological features of these tumors were similar to those seen in meningiomas in other locations.
  • CONCLUSIONS: Intraventricular meningiomas are slow-growing tumors that become large prior to detection.
  • The histopathological features are varied, although most of the tumors in the study were angiomatous meningiomas.
  • [MeSH-major] Cerebral Ventricle Neoplasms / pathology. Meningeal Neoplasms / pathology. Meningioma / pathology

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  • (PMID = 16599425.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 26
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19. Hayashi Y, Uchiyama N, Hayashi Y, Nakada M, Iwato M, Kita D, Higashi R, Hirota Y, Kai Y, Kuratsu J, Hamada J: A reevaluation of the primary diagnosis of hemangiopericytoma and the clinical importance of differential diagnosis from solitary fibrous tumor of the central nervous system. Clin Neurol Neurosurg; 2009 Jan;111(1):34-8
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  • Though the differential diagnoses from angiomatous meningiomas and from solitary fibrous tumors (SFTs) are both important, the latter diagnosis is somewhat more important in light of the benign prognosis of SFTs and the difficulties in distinguishing SFTs from HPCs.
  • One case was newly diagnosed as meningioma on the basis of a strong EMA positivity.
  • In two cases, one case of HPC and the other of meningioma, the MIB-1 LI was relatively high, 8% and 4% respectively.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Central Nervous System Neoplasms / diagnosis. Hemangiopericytoma / diagnosis. Meningioma / diagnosis. Solitary Fibrous Tumors / diagnosis

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  • (PMID = 18922629.001).
  • [ISSN] 1872-6968
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / Mucin-1; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / S100 Proteins; 0 / Vimentin
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20. Zhang H, Rödiger LA, Shen T, Miao J, Oudkerk M: Preoperative subtyping of meningiomas by perfusion MR imaging. Neuroradiology; 2008 Oct;50(10):835-40

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Preoperative subtyping of meningiomas by perfusion MR imaging.
  • INTRODUCTION: This paper aims to evaluate the value of perfusion magnetic resonance (MR) imaging in the preoperative subtyping of meningiomas by analyzing the relative cerebral blood volume (rCBV) of three benign subtypes and anaplastic meningiomas separately.
  • MATERIALS AND METHODS: Thirty-seven meningiomas with peritumoral edema (15 meningothelial, ten fibrous, four angiomatous, and eight anaplastic) underwent perfusion MR imaging by using a gradient echo echo-planar sequence.
  • RESULTS: The mean rCBV of meningothelial, fibrous, angiomatous, and anaplastic meningiomas in tumoral parenchyma were 6.93 +/- 3.75, 5.61 +/- 4.03, 11.86 +/- 1.93, and 5.89 +/- 3.85, respectively, and in the peritumoral edema 0.87 +/- 0.62, 1.38 +/- 1.44, 0.87 +/- 0.30, and 3.28 +/- 1.39, respectively.
  • The mean rCBV in tumoral parenchyma of angiomatous meningiomas and in the peritumoral edema of anaplastic meningiomas were statistically different (p < 0.05) from the other types of meningiomas.
  • CONCLUSION: Perfusion MR imaging can provide useful functional information on meningiomas and help in the preoperative diagnosis of some subtypes of meningiomas.
  • [MeSH-major] Magnetic Resonance Angiography / methods. Meningeal Neoplasms / pathology. Meningioma / pathology

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  • (PMID = 18542938.001).
  • [ISSN] 0028-3940
  • [Journal-full-title] Neuroradiology
  • [ISO-abbreviation] Neuroradiology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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21. Hartmann C, Sieberns J, Gehlhaar C, Simon M, Paulus W, von Deimling A: NF2 mutations in secretory and other rare variants of meningiomas. Brain Pathol; 2006 Jan;16(1):15-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] NF2 mutations in secretory and other rare variants of meningiomas.
  • The WHO classification defines different histological variants of meningiomas.
  • Mutations of the tumor suppressor gene NF2 on 22q have been described in 30% to 60 % of sporadic meningiomas.
  • However, the vast majority of the meningiomas that have been subject to NF2 analysis belong to the most frequent variants like transitional, fibroblastic and meningothelial meningiomas.
  • Within these subtypes, transitional and fibroblastic meningiomas harbor significantly more NF2 mutations than meningothelial meningiomas, indicating molecular subsets of these tumors.
  • To determine whether rare meningioma variants carry NF2 mutations we analyzed 80 tumors.
  • NF2 mutations were detected in 5 (36%) of 14 psammomatous, 1 (11%) of 9 angiomatous, 2 (22%) of 9 clear cell, 1 (33%) of 3 chordoid and 1 (100%) of 1 papillary meningioma.
  • In the single papillary meningioma, 2 different NF2 mutations were observed.
  • No NF2 mutations were found in 33 secretory, 7 microcystic, 2 lymphoplasmacyte-rich, one rhabdoid and one metaplastic meningioma.
  • In the control group of 25 fibroblastic meningiomas, 11 cases were identified to carry an NF2 mutation.
  • These results support the concept of different molecular subgroups of meningiomas which overlap with histological variants.
  • [MeSH-major] Genes, Neurofibromatosis 2 / physiology. Meningeal Neoplasms / genetics. Meningioma / genetics

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  • (PMID = 16612978.001).
  • [ISSN] 1015-6305
  • [Journal-full-title] Brain pathology (Zurich, Switzerland)
  • [ISO-abbreviation] Brain Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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22. Pećina-Slaus N, Nikuseva Martić T, Tomas D, Beros V, Zeljko M, Cupić H: Meningiomas exhibit loss of heterozygosity of the APC gene. J Neurooncol; 2008 Mar;87(1):63-70

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Meningiomas exhibit loss of heterozygosity of the APC gene.
  • The molecular mechanisms and candidate genes involved in development of meningiomas still need investigation and elucidation.
  • In the present study 33 meningiomas were analyzed regarding genetic changes of tumor suppressor gene Adenomatous polyposis coli (APC), a component of the wnt signaling.
  • The changes were distributed according to pathohistological grade as follows: 46% of meningothelial meningioma showed LOH; 33% of fibrous; 75% of mixed (transitional); 75% of angiomatous, and one LOH was found in a single case of psammomatous meningioma.
  • The results of this investigation suggest that genetic changes of APC gene play a role in meningioma formation.
  • [MeSH-major] Genes, APC. Loss of Heterozygosity. Meningeal Neoplasms / genetics. Meningioma / genetics

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  • (PMID = 18066497.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
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23. Pećina-Slaus N, Nikuseva Martić T, Deak AJ, Zeljko M, Hrasćan R, Tomas D, Musani V: Genetic and protein changes of E-cadherin in meningiomas. J Cancer Res Clin Oncol; 2010 May;136(5):695-702
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Genetic and protein changes of E-cadherin in meningiomas.
  • PURPOSE: The molecular mechanisms and candidate genes involved in development of meningiomas still needs investigation and elucidation.
  • METHODS: In the present study 60 meningiomas were analyzed regarding changes of tumor suppressor gene E-cadherin (CDH1), a component of adherens junction and an indirect modulator of the wnt signaling.
  • Fibrous and angiomatous cases showed higher percent of genetic changes, 67 and 75%, respectively.
  • CONCLUSIONS: Our results suggest that genetic instabilities of the E-cadherin gene have a role in meningioma development and progression.
  • Detected microsatellite instability indicates that mismatch repair may also be targeted in meningioma.
  • [MeSH-major] Cadherins / genetics. Genomic Instability. Meningeal Neoplasms / genetics. Meningioma / genetics

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  • (PMID = 19908067.001).
  • [ISSN] 1432-1335
  • [Journal-full-title] Journal of cancer research and clinical oncology
  • [ISO-abbreviation] J. Cancer Res. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Cadherins; 0 / beta Catenin
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24. Caffo M, Caruso G, Germanò A, Galatioto S, Meli F, Tomasello F: CD68 and CR3/43 immunohistochemical expression in secretory meningiomas. Neurosurgery; 2005 Sep;57(3):551-7; discussion 551-7
MedlinePlus Health Information. consumer health - Brain Tumors.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] CD68 and CR3/43 immunohistochemical expression in secretory meningiomas.
  • OBJECTIVE: Secretory meningiomas (SMs) are unusual benign meningiomas.
  • SMs are highly vascularized lesions, with angiomatous features and a perivascular arrangement, and they are accompanied frequently by massive peritumoral edema.
  • CONCLUSION: Macrophage infiltration and major histocompatibility complex Class II immunoreactivity in this subtype of meningioma suggest the occurrence of an immune response in the presence of SM.
  • [MeSH-major] Antigens, CD / metabolism. Antigens, Differentiation, Myelomonocytic / metabolism. Brain Neoplasms / metabolism. Immunohistochemistry / methods. Macrophage-1 Antigen / metabolism. Meningioma / metabolism

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  • (PMID = 16145535.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / CD68 antigen, human; 0 / Macrophage-1 Antigen
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25. Hakyemez B, Yildirim N, Gokalp G, Erdogan C, Parlak M: The contribution of diffusion-weighted MR imaging to distinguishing typical from atypical meningiomas. Neuroradiology; 2006 Aug;48(8):513-20
MedlinePlus Health Information. consumer health - Childhood Brain Tumors.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The contribution of diffusion-weighted MR imaging to distinguishing typical from atypical meningiomas.
  • INTRODUCTION: Atypical/malignant meningiomas recur more frequently then typical meningiomas.
  • In this study, the contribution of diffusion-weighted MR imaging to the differentiation of atypical/malignant and typical meningiomas and to the determination of histological subtypes of typical meningiomas was investigated.
  • RESULTS: Mean ADC values in atypical/malignant and typical meningiomas were 0.75+/-0.21 and 1.17+/-0.21, respectively.
  • Mean ADC values for subtypes of typical meningiomas were as follows: meningothelial, 1.09+/-0.20; transitional, 1.19+/-0.07; fibroblastic, 1.29+/-0.28; and angiomatous, 1.48+/-0.10.
  • ADC values of typical meningiomas and atypical/malignant meningiomas significantly differed (P<0.001).
  • Furthermore, the difference between the subtypes of typical meningiomas and atypical/malignant meningiomas was significant (P<0.001).
  • CONCLUSION: Diffusion-weighted MR imaging findings of atypical/malignant meningiomas and typical meningiomas differ.
  • Atypical/malignant meningiomas have lower intratumoral ADC values than typical meningiomas.
  • Mean ADC values for peritumoral edema do not differ between typical and atypical meningiomas.
  • [MeSH-major] Brain Neoplasms / diagnosis. Diffusion Magnetic Resonance Imaging. Meningeal Neoplasms / diagnosis. Meningioma / diagnosis

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  • (PMID = 16786348.001).
  • [ISSN] 0028-3940
  • [Journal-full-title] Neuroradiology
  • [ISO-abbreviation] Neuroradiology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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