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Items 1 to 46 of about 46
1. Mansfield A, Larson B, Stafford SL, Shives TC, Haddock MG, Dingli D: Angiomatoid fibrous histiocytoma in a 25-year-old male. Rare Tumors; 2010;2(2):e20
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  • [Title] Angiomatoid fibrous histiocytoma in a 25-year-old male.
  • Angiomatoid fibrous histiocytoma (AFH) is a rare disease that is often misdiagnosed initially.

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  • (PMID = 21139823.001).
  • [ISSN] 2036-3613
  • [Journal-full-title] Rare tumors
  • [ISO-abbreviation] Rare Tumors
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2994511
  • [Keywords] NOTNLM ; angiomatoid fibrous histiocytoma / soft tissue tumor.
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2. Tanas MR, Rubin BP, Montgomery EA, Turner SL, Cook JR, Tubbs RR, Billings SD, Goldblum JR: Utility of FISH in the diagnosis of angiomatoid fibrous histiocytoma: a series of 18 cases. Mod Pathol; 2010 Jan;23(1):93-7
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  • [Title] Utility of FISH in the diagnosis of angiomatoid fibrous histiocytoma: a series of 18 cases.
  • Angiomatoid fibrous histiocytoma is a mesenchymal neoplasm of intermediate malignancy and uncertain histogenesis/line of differentiation, which occurs most commonly in the extremities of children to young adults.
  • It has a characteristic appearance characterized by a proliferation of histiocytoid cells with a lymphoid cuff and fibrous pseudocapsule, simulating the appearance of a neoplasm occurring within a lymph node.
  • Angiomatoid fibrous histiocytoma has been found to harbor three related translocations, a t(12;16)(q13;p11) resulting in a FUS/ATF1 fusion gene, t(12;22)(q13;q12) resulting in a EWSR1/ATF1 fusion, and t(2;22)(q33;q12) resulting in a EWSR1/CREB1 fusion.
  • We evaluated 18 cases of angiomatoid fibrous histiocytoma for rearrangements of EWSR1 and FUS by FISH, the largest series to date.
  • We found that 13 of 17 (76%) cases of angiomatoid fibrous histiocytoma harbored rearrangements of EWSR1; rearrangements of FUS were not detected in any of the cases.
  • This study affirms that the rearrangement of EWSR1 is a common genetic event in angiomatoid fibrous histiocytoma, and is thus useful diagnostically.
  • This study supports the fact that the rearrangement of FUS is present in only a small minority of angiomatoid fibrous histiocytomas.
  • Although it is possible that these cases contained cryptic rearrangements of EWSR1 or FUS that were not detectable by our FISH probes, it also raises the possibility that another translocation/gene fusion may be present in angiomatoid fibrous histiocytoma.
  • [MeSH-major] Biomarkers, Tumor / genetics. Calmodulin-Binding Proteins / genetics. Histiocytoma, Malignant Fibrous / genetics. In Situ Hybridization, Fluorescence. RNA-Binding Protein FUS / genetics. RNA-Binding Proteins / genetics

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  • (PMID = 19801966.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Calmodulin-Binding Proteins; 0 / EWSR1 protein, human; 0 / RNA-Binding Protein FUS; 0 / RNA-Binding Proteins
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3. Grogg KL, Macon WR, Kurtin PJ, Nascimento AG: A survey of clusterin and fascin expression in sarcomas and spindle cell neoplasms: strong clusterin immunostaining is highly specific for follicular dendritic cell tumor. Mod Pathol; 2005 Feb;18(2):260-6
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  • We evaluated staining for antibodies directed against these two antigens in 202 spindle cell tumors, including cases of follicular dendritic cell tumor (n=14), interdigitating dendritic cell tumor (n=7), leiomyosarcoma (n=17), inflammatory myofibroblastic tumor (n=13), inflammatory pseudotumor (n=2), spindle cell thymoma (n=17), synovial sarcoma (n=11), fibrosarcoma (n=14), liposarcoma (n=27), gastrointestinal stromal tumor (n=13), malignant fibrous histiocytoma (n=18), angiomatoid fibrous histiocytoma (n=4), angiosarcoma (n=10), malignant peripheral nerve sheath tumor (n=8), malignant melanoma (n=16), and spindle cell carcinoma (n=11).
  • Clusterin staining was least reliable in distinguishing follicular dendritic cell tumor from spindle cell thymoma or malignant fibrous histiocytoma, but these are entities that usually can be distinguished by clinical and morphologic data.

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  • (PMID = 15467709.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CLU protein, human; 0 / Carrier Proteins; 0 / Clusterin; 0 / Glycoproteins; 0 / Microfilament Proteins; 0 / Molecular Chaperones; 146808-54-0 / fascin
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4. Guo H, Xiong Y, Nong L, Zhang S, Li T: [Reassessment of the pathological diagnosis in 33 cases of malignant fibrous histiocytoma]. Beijing Da Xue Xue Bao; 2008 Aug 18;40(4):374-9
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  • [Title] [Reassessment of the pathological diagnosis in 33 cases of malignant fibrous histiocytoma].
  • OBJECTIVE: Since malignant fibrous histiocytoma (MFH) may be taken as an undifferentiated pleomorphic sarcoma (UPS), this study was conducted to reassess 33 previously diagnosed MFH cases in the past 10 years based on the latest WHO concept.
  • RESULTS: Among the 33 cases, 17 cases (51.5%) of MFH had their diagnoses changed, including 5 leiomyosarcomas, 3 malignant peripheral nerve sheath tumors, 1 fibrosarcoma, 1 inflammatory myofibrosarcoma, 1 giant cell tumor and 1 angiomatoid fibrous histiocytoma.
  • Eleven cases (68.8%) variously expressed CD68 (KP1) and 7 cases (43.8%) expressed CD68 (PG-M1), which were much higher than leiomyosarcoma, malignant peripheral nerve sheath tumor and liposarcoma with significant difference.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology

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  • (PMID = 18677383.001).
  • [ISSN] 1671-167X
  • [Journal-full-title] Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences
  • [ISO-abbreviation] Beijing Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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5. Hallor KH, Micci F, Meis-Kindblom JM, Kindblom LG, Bacchini P, Mandahl N, Mertens F, Panagopoulos I: Fusion genes in angiomatoid fibrous histiocytoma. Cancer Lett; 2007 Jun 18;251(1):158-63
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  • [Title] Fusion genes in angiomatoid fibrous histiocytoma.
  • Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumor of low malignant potential and uncertain differentiation.
  • [MeSH-major] Histiocytoma, Malignant Fibrous / pathology. Oncogene Proteins, Fusion / genetics

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  • (PMID = 17188428.001).
  • [ISSN] 0304-3835
  • [Journal-full-title] Cancer letters
  • [ISO-abbreviation] Cancer Lett.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / ATF1 protein, human; 0 / Activating Transcription Factor 1; 0 / Calmodulin-Binding Proteins; 0 / DNA-Binding Proteins; 0 / EWSR1 protein, human; 0 / Nuclear Proteins; 0 / Oncogene Proteins, Fusion; 0 / RNA-Binding Protein FUS; 0 / RNA-Binding Proteins; 0 / Transcription Factors; 0 / regulatory factor X transcription factors
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6. Shin JW, Park HS, Kim BK, Kim YA, Kim MG, Won CH, Cho S: Aneurysmal benign fibrous histiocytoma with atrophic features. Ann Dermatol; 2009 Feb;21(1):42-5

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  • [Title] Aneurysmal benign fibrous histiocytoma with atrophic features.
  • Aneurysmal benign fibrous histiocytoma is an uncommon pathologic variant of dermatofibroma.
  • It should be differentiated from angiomatoid malignant fibrous histiocytoma, malignant melanoma, and vascular tumors such as Kaposi's sarcoma and angiosarcoma.
  • We report a case of aneurysmal benign fibrous histiocytoma with atrophic features in a 27-year-old male who had a grayish-brown atrophic patchy lesion on his back for 2 years.

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  • (PMID = 20548854.001).
  • [ISSN] 2005-3894
  • [Journal-full-title] Annals of dermatology
  • [ISO-abbreviation] Ann Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2883367
  • [Keywords] NOTNLM ; Aneurysmal variant / Atrophy / Dermatofibroma
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7. García JJ, Folpe AL: The impact of advances in molecular genetic pathology on the classification, diagnosis and treatment of selected soft tissue tumors of the head and neck. Head Neck Pathol; 2010 Mar;4(1):70-6
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  • This reviews details some ways in which molecular techniques have strengthened conventional diagnostic and management approaches to low-grade fibromyxoid sarcoma, angiomatoid (malignant) fibrous histiocytoma, and dermatofibrosarcoma protuberans, all of which may involve the head and neck region.
  • [MeSH-major] Angiomatosis / genetics. Dermatofibrosarcoma / genetics. Head and Neck Neoplasms / genetics. Histiocytoma, Benign Fibrous / genetics. Pathology, Molecular / trends. Soft Tissue Neoplasms / genetics

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  • (PMID = 20237992.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 22
  • [Other-IDs] NLM/ PMC2825525
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8. Rossi S, Szuhai K, Ijszenga M, Tanke HJ, Zanatta L, Sciot R, Fletcher CD, Dei Tos AP, Hogendoorn PC: EWSR1-CREB1 and EWSR1-ATF1 fusion genes in angiomatoid fibrous histiocytoma. Clin Cancer Res; 2007 Dec 15;13(24):7322-8
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  • [Title] EWSR1-CREB1 and EWSR1-ATF1 fusion genes in angiomatoid fibrous histiocytoma.
  • PURPOSE: Angiomatoid fibrous histiocytoma (AFH) is a low-grade mesenchymal neoplasm which usually occurs in children and adolescents.
  • [MeSH-major] Cyclic AMP Response Element-Binding Protein / genetics. Histiocytoma, Malignant Fibrous / genetics. Oncogene Proteins, Fusion / genetics. Soft Tissue Neoplasms / genetics. Transcription Factors / genetics

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  • (PMID = 18094413.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CREB1 protein, human; 0 / Cyclic AMP Response Element-Binding Protein; 0 / EWS-ATF1 fusion protein, human; 0 / Oncogene Proteins, Fusion; 0 / Transcription Factors
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9. Antonescu CR, Dal Cin P, Nafa K, Teot LA, Surti U, Fletcher CD, Ladanyi M: EWSR1-CREB1 is the predominant gene fusion in angiomatoid fibrous histiocytoma. Genes Chromosomes Cancer; 2007 Dec;46(12):1051-60
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  • [Title] EWSR1-CREB1 is the predominant gene fusion in angiomatoid fibrous histiocytoma.
  • The molecular hallmark of angiomatoid fibrous histiocytoma (AFH) is not well defined, with only six cases with specific gene fusions reported to date, consisting of either FUS-ATF1 or EWSR1-ATF1.
  • EWSR1-ATF1, identified in some AFH cases, is the most common genetic abnormality in soft tissue clear cell sarcoma.
  • [MeSH-major] Calmodulin-Binding Proteins / genetics. Cyclic AMP Response Element-Binding Protein / genetics. Gene Fusion. Histiocytoma, Malignant Fibrous / genetics. RNA-Binding Proteins / genetics

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  • [Copyright] (c) 2007 Wiley-Liss, Inc.
  • (PMID = 17724745.001).
  • [ISSN] 1045-2257
  • [Journal-full-title] Genes, chromosomes & cancer
  • [ISO-abbreviation] Genes Chromosomes Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CREB1 protein, human; 0 / Calmodulin-Binding Proteins; 0 / Cyclic AMP Response Element-Binding Protein; 0 / EWSR1 protein, human; 0 / RNA-Binding Proteins
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10. Matsumura T, Yamaguchi T, Tochigi N, Wada T, Yamashita T, Hasegawa T: Angiomatoid fibrous histiocytoma including cases with pleomorphic features analysed by fluorescence in situ hybridisation. J Clin Pathol; 2010 Feb;63(2):124-8
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  • [Title] Angiomatoid fibrous histiocytoma including cases with pleomorphic features analysed by fluorescence in situ hybridisation.
  • BACKGROUND: Angiomatoid fibrous histiocytoma (AFH) is a rare soft-tissue tumour of uncertain differentiation and low metastatic potential.
  • [MeSH-major] Histiocytoma, Benign Fibrous / genetics. Soft Tissue Neoplasms / genetics

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  • (PMID = 20154033.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Calmodulin-Binding Proteins; 0 / EWSR1 protein, human; 0 / Neoplasm Proteins; 0 / RNA-Binding Protein FUS; 0 / RNA-Binding Proteins
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11. Ochalski PG, Edinger JT, Horowitz MB, Stetler WR, Murdoch GH, Kassam AB, Engh JA: Intracranial angiomatoid fibrous histiocytoma presenting as recurrent multifocal intraparenchymal hemorrhage. J Neurosurg; 2010 May;112(5):978-82
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  • [Title] Intracranial angiomatoid fibrous histiocytoma presenting as recurrent multifocal intraparenchymal hemorrhage.
  • Angiomatoid fibrous histiocytoma (AFH) is a rare soft-tissue neoplasm that most commonly appears in the limbs, typically affecting children and young adults.
  • [MeSH-major] Angiomatosis / complications. Angiomatosis / pathology. Cerebral Hemorrhage / complications. Cerebral Hemorrhage / pathology. Histiocytoma, Benign Fibrous / complications. Histiocytoma, Benign Fibrous / pathology

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  • (PMID = 19731989.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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12. Thway K: Angiomatoid fibrous histiocytoma: a review with recent genetic findings. Arch Pathol Lab Med; 2008 Feb;132(2):273-7
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  • [Title] Angiomatoid fibrous histiocytoma: a review with recent genetic findings.
  • Angiomatoid fibrous histiocytoma is a neoplasm of intermediate biologic potential most often arising in the extremities of children and young adults.
  • Originally described as a type of malignant fibrous histiocytoma, its differentiation remains enigmatic, with precise histogenesis still only hypothesized.
  • The literature on angiomatoid fibrous histiocytoma is reviewed, particularly with regard to recent molecular genetic developments and differentiation, and its morphology, immunohistochemistry, and differential diagnosis are summarized.
  • [MeSH-major] Histiocytoma, Malignant Fibrous / genetics. Soft Tissue Neoplasms / genetics. Translocation, Genetic / genetics

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  • (PMID = 18251589.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Desmin
  • [Number-of-references] 27
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13. Mangham DC, Williams A, Lalam RK, Brundler MA, Leahy MG, Cool WP: Angiomatoid fibrous histiocytoma of bone: a calcifying sclerosing variant mimicking osteosarcoma. Am J Surg Pathol; 2010 Feb;34(2):279-85
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  • [Title] Angiomatoid fibrous histiocytoma of bone: a calcifying sclerosing variant mimicking osteosarcoma.
  • Angiomatoid fibrous histiocytoma is a neoplasm of uncertain histogenesis, which most commonly arises in the subcutaneous tissue of the extremities of children and young adults.
  • This case arose in bone-a site where there has been just 1 previously published case of typical (nonsclerosing/mineralizing) angiomatoid fibrous histiocytoma.
  • Due to the rarity of angiomatoid fibrous histiocytoma at this site and the presence of matrical sclerosis/mineralization, this case raised the important differential diagnosis of osteosarcoma, both histologically and radiologically.
  • [MeSH-major] Bone Neoplasms / pathology. Histiocytoma, Benign Fibrous / pathology. Osteosarcoma / diagnosis

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  • (PMID = 20090505.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / EWS-ATF1 fusion protein, human; 0 / Oncogene Proteins, Fusion; 0 / Transcription Factors
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14. Lai EC, Chung KM, Chiu HF, Lau WY: Angiomatoid fibrous histiocytoma in the neck. ANZ J Surg; 2006 Jun;76(6):538
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  • [Title] Angiomatoid fibrous histiocytoma in the neck.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Histiocytoma, Malignant Fibrous / pathology

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  • (PMID = 16768787.001).
  • [ISSN] 1445-1433
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Australia
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15. Filingeri V, Gravante G, Marino B, Fratoni S, Schiaroli S: A rare case of cystic variety of angiomatoid fibrous histiocytoma. Eur Rev Med Pharmacol Sci; 2010 Oct;14(10):887-90
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  • [Title] A rare case of cystic variety of angiomatoid fibrous histiocytoma.
  • A rare case of cystic angiomatoid fibrous histiocytoma of the thigh in a 13-years-old girl is reported.
  • [MeSH-major] Cysts / pathology. Histiocytoma, Malignant Fibrous / pathology

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  • [ErratumIn] Eur Rev Med Pharmacol Sci. 2010 Dec;14(12):1074. Gravante, G [corrected to Bellini, I]
  • [ErratumIn] Eur Rev Med Pharmacol Sci. 2011 Mar;15(3):352. Bellini, I [corrected to Gravante, G]
  • (PMID = 21222377.001).
  • [ISSN] 1128-3602
  • [Journal-full-title] European review for medical and pharmacological sciences
  • [ISO-abbreviation] Eur Rev Med Pharmacol Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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16. Patrizi A, Tabanelli M, Filippi G, Gurioli C, Nozza P, Savoia F, Dalmonte P, Misciali C: An angiomatoid fibrous histiocytoma over the left pre auricular region in a 13-year-old boy. Dermatol Online J; 2010;16(5):4
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  • [Title] An angiomatoid fibrous histiocytoma over the left pre auricular region in a 13-year-old boy.
  • An incisional biopsy was performed and revealed an angiomatoid fibrous histiocytoma (AFH).
  • Angiomatoid fibrous histiocytoma (AFH) is a rare tumor of the soft tissue with fibrohistiocytic and vascular differentiation that shows an intermediate malignancy grade, mainly occurs in patients younger than 20 years of age, and is usually localized on the extremities.
  • Angiomatoid fibrous histiocytoma is considered to be a tumor of intermediate malignancy because of its less aggressive course in contrast to conventional malignant fibrous histiocytoma (MFH).
  • [MeSH-major] Histiocytoma, Malignant Fibrous / pathology. Skin Neoplasms / pathology

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  • (PMID = 20492821.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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17. Dunham C, Hussong J, Seiff M, Pfeifer J, Perry A: Primary intracerebral angiomatoid fibrous histiocytoma: report of a case with a t(12;22)(q13;q12) causing type 1 fusion of the EWS and ATF-1 genes. Am J Surg Pathol; 2008 Mar;32(3):478-84
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  • [Title] Primary intracerebral angiomatoid fibrous histiocytoma: report of a case with a t(12;22)(q13;q12) causing type 1 fusion of the EWS and ATF-1 genes.
  • Angiomatoid fibrous histiocytoma (AFH) is generally considered a soft tissue sarcoma of low malignant potential that occurs in children/young adults and most frequently affects the extremities.
  • [MeSH-major] Brain Neoplasms / genetics. Chromosomes, Human, Pair 12. Chromosomes, Human, Pair 22. DNA-Binding Proteins / genetics. Gene Fusion. Histiocytoma, Malignant Fibrous / genetics. Nuclear Proteins / genetics. RNA-Binding Protein EWS / genetics. Translocation, Genetic

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  • (PMID = 18300800.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ATF1 protein, human; 0 / Activating Transcription Factor 1; 0 / DNA-Binding Proteins; 0 / Nuclear Proteins; 0 / RNA-Binding Protein EWS; 0 / Transcription Factors; 0 / regulatory factor X transcription factors
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18. Hallor KH, Mertens F, Jin Y, Meis-Kindblom JM, Kindblom LG, Behrendtz M, Kalén A, Mandahl N, Panagopoulos I: Fusion of the EWSR1 and ATF1 genes without expression of the MITF-M transcript in angiomatoid fibrous histiocytoma. Genes Chromosomes Cancer; 2005 Sep;44(1):97-102
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  • [Title] Fusion of the EWSR1 and ATF1 genes without expression of the MITF-M transcript in angiomatoid fibrous histiocytoma.
  • Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumor that usually occurs in children and young adults.
  • [MeSH-major] Artificial Gene Fusion. Calmodulin-Binding Proteins / genetics. DNA-Binding Proteins / genetics. Histiocytoma, Benign Fibrous / genetics. Nuclear Proteins / genetics. RNA-Binding Proteins / genetics. Transcription Factors / genetics

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  • [Copyright] (c) 2005 Wiley-Liss, Inc.
  • (PMID = 15884099.001).
  • [ISSN] 1045-2257
  • [Journal-full-title] Genes, chromosomes & cancer
  • [ISO-abbreviation] Genes Chromosomes Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ATF1 protein, human; 0 / Activating Transcription Factor 1; 0 / Calmodulin-Binding Proteins; 0 / DNA Primers; 0 / DNA-Binding Proteins; 0 / EWSR1 protein, human; 0 / MITF protein, human; 0 / Microphthalmia-Associated Transcription Factor; 0 / Nuclear Proteins; 0 / RNA-Binding Proteins; 0 / Transcription Factors; 0 / regulatory factor X transcription factors
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19. Sutthiruangwong P, Thanakit V, Assavamongkolkul A: Angiomatoid fibrous histiocytoma with pain in a child. J Med Assoc Thai; 2005 Oct;88(10):1453-7
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  • [Title] Angiomatoid fibrous histiocytoma with pain in a child.
  • Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumor with low-grade malignancy which occurs chiefly in children and young adults.
  • [MeSH-major] Histiocytoma, Malignant Fibrous / complications. Pain / etiology. Soft Tissue Neoplasms / complications. Subcutaneous Tissue

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  • (PMID = 16519396.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Thailand
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20. Cernik C, Channaiah D, Trevino J: Angiomatoid fibrous histiocytoma in a six-year-old child. Pediatr Dermatol; 2009 Sep-Oct;26(5):636-8
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  • [Title] Angiomatoid fibrous histiocytoma in a six-year-old child.
  • The histology is characterized by a fibrous capsule, surrounding lymphocytic infiltrate and blood-filled cystic spaces lined by flattened tumor cells.
  • [MeSH-major] Hemangioma / pathology. Histiocytoma, Malignant Fibrous / pathology. Skin Neoplasms / pathology

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  • (PMID = 19840338.001).
  • [ISSN] 1525-1470
  • [Journal-full-title] Pediatric dermatology
  • [ISO-abbreviation] Pediatr Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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21. Yu H, Wang CF, Yang WT, Zhu XZ: [Angiomatoid fibrous histiocytoma: report of 5 cases with review of literature]. Zhonghua Bing Li Xue Za Zhi; 2010 Apr;39(4):245-8
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  • [Title] [Angiomatoid fibrous histiocytoma: report of 5 cases with review of literature].
  • OBJECTIVE: To study the clinicopathologic features, immunophenotype and differential diagnosis of angiomatoid fibrous histiocytoma (AFH).
  • Fibrillary neuropil-type intercellular material was identified in all cases and a fibrous pseudocapsule surrounded by lymphocytes and plasma cells was demonstrated in 3 cases.
  • CONCLUSIONS: AFH is a rare tumor of intermediate malignant potential.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aneurysm / metabolism. Aneurysm / pathology. Antigens, CD / metabolism. Antigens, Differentiation, Myelomonocytic / metabolism. Chemotherapy, Adjuvant. Child. Desmin / metabolism. Diagnosis, Differential. Female. Follow-Up Studies. Histiocytoma, Malignant Fibrous / pathology. Humans. Male. Radiotherapy, Adjuvant. Vimentin / metabolism. Young Adult

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  • (PMID = 20654123.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / CD68 antigen, human; 0 / Desmin; 0 / Vimentin
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22. Pratibha R, Ahmed S: Angiomatoid variant of fibrous histiocytoma: a case report and review of literature. Int J Paediatr Dent; 2006 Sep;16(5):363-9
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  • [Title] Angiomatoid variant of fibrous histiocytoma: a case report and review of literature.
  • Fibrous histiocytomas by themselves are not very common in the head and neck region.
  • Apart from considering the above fact, this report describes a unique and relatively rare variant of the neoplasm - the angiomatoid fibrous histiocytoma (AFH) which has a characteristic appearance and predilection for young individuals that occurred in the left lower border of the mandible in a 13-year-old girl.
  • Angiomatoid fibrous histiocytoma is a distinct fibrohistiocytic tumour of children and young adults that combines features of both fibrohistiocytic and vascular neoplasm.
  • It is considered to be a tumour of intermediate malignancy because of its less aggressive course in contrast to the conventional malignant fibrous histiocytoma.

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  • (PMID = 16879335.001).
  • [ISSN] 0960-7439
  • [Journal-full-title] International journal of paediatric dentistry
  • [ISO-abbreviation] Int J Paediatr Dent
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 35
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23. Sabah M, Cummins R, Leader M, Kay E: Leiomyosarcoma and malignant fibrous histiocytoma share similar allelic imbalance pattern at 9p. Virchows Arch; 2005 Mar;446(3):251-8
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  • [Title] Leiomyosarcoma and malignant fibrous histiocytoma share similar allelic imbalance pattern at 9p.
  • The specimens consisted of 17 cases of soft tissue leiomyosarcoma (LMS), 4 cases of cutaneous LMS, 22 cases of conventional malignant fibrous histiocytoma (MFH) and 2 cases of angiomatoid fibrous histiocytoma.
  • The frequency of allelic imbalance at different loci on chromosome 9p was analysed in LMS and MFH and then compared with values previously examined in synovial sarcoma and malignant peripheral nerve sheath tumour.
  • Alterations of this locus were very rare in synovial sarcoma and malignant peripheral nerve sheath tumours and were absent in cutaneous LMS and angiomatoid fibrous histiocytoma.
  • [MeSH-major] Chromosomes, Human, Pair 9 / genetics. DNA, Neoplasm / genetics. Histiocytoma, Benign Fibrous / genetics. Leiomyosarcoma / genetics. Soft Tissue Neoplasms / genetics

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  • [Title] Angiomatoid fibrous histiocytoma in an HIV-positive child.
  • Children with human immunodeficiency virus are at higher risk of developing tumor than the general population, non-Hodgkin lymphoma and Kaposi sarcoma being the most frequent malignant tumor in these patients.
  • The report describes the case of a human immunodeficiency virus-seropositive girl who developed an angiomatoid fibrous histiocytoma of the soft part of the right knee.
  • [MeSH-major] HIV Infections / complications. Hemangioma / diagnosis. Histiocytoma, Malignant Fibrous / diagnosis. Knee / pathology


25. Romeo S, Dei Tos AP: Soft tissue tumors associated with EWSR1 translocation. Virchows Arch; 2010 Feb;456(2):219-34
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  • In fact, it is involved in a broad variety of mesenchymal lesions which includes Ewing's sarcoma/peripheral neuroectodermal tumor, desmoplastic small round cell tumor,clear cell sarcoma, angiomatoid fibrous histiocytoma, extraskeletal myxoid chondrosarcoma, and a subset of myxoid liposarcoma.

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  • (PMID = 19936782.001).
  • [ISSN] 1432-2307
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Calmodulin-Binding Proteins; 0 / EWSR1 protein, human; 0 / RNA-Binding Proteins
  • [Number-of-references] 124
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26. Wang HY, Fan QH, Gong QX, Wang Z: [Clinicopathologic characteristics of hemangiopericytoma/solitary fibrous tumor with giant cells]. Zhonghua Bing Li Xue Za Zhi; 2009 Mar;38(3):169-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinicopathologic characteristics of hemangiopericytoma/solitary fibrous tumor with giant cells].
  • OBJECTIVE: To study the pathological characteristics, diagnosis and differential diagnoses of hemangiopericytoma-solitary fibrous tumor with giant cells.
  • METHODS: Pathological characteristics of seven cases of orbital and extraorbital hemangiopericytoma-solitary fibrous tumors with giant cells were evaluated by HE and immunohistochemistry (EnVision method).
  • CONCLUSIONS: Hemangiopericytoma-solitary fibrous tumor with giant cells is an intermediate soft tissue tumor.
  • Histologically, the tumor should be distinguished from giant cell fibroblastoma, pleomorphic hyalinzing angiectatic tumor of soft part and angiomatoid fibrous histiocytoma.
  • [MeSH-major] Hemangiopericytoma / pathology. Orbital Neoplasms / pathology. Solitary Fibrous Tumors / pathology
  • [MeSH-minor] Adult. Antigens, CD / metabolism. Antigens, CD34 / metabolism. Cell Adhesion Molecules / metabolism. Dermatofibrosarcoma / pathology. Diagnosis, Differential. Female. Follow-Up Studies. Histiocytoma, Benign Fibrous / pathology. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Recurrence, Local. Proto-Oncogene Proteins c-bcl-2 / metabolism. Soft Tissue Neoplasms / pathology. Solitary Fibrous Tumor, Pleural / metabolism. Solitary Fibrous Tumor, Pleural / pathology. Solitary Fibrous Tumor, Pleural / surgery. Young Adult

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  • (PMID = 19575851.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD34; 0 / CD99 protein, human; 0 / Cell Adhesion Molecules; 0 / Proto-Oncogene Proteins c-bcl-2
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27. Meis-Kindblom JM: Clear cell sarcoma of tendons and aponeuroses: a historical perspective and tribute to the man behind the entity. Adv Anat Pathol; 2006 Nov;13(6):286-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Ultrastructural and immunohistochemical studies have shown melanocytic differentiation, whereas molecular genetic studies have shown cytogenetic rearrangements resulting in a EWSR1-ATF1 fusion gene that is characteristic but not entirely unique for clear cell sarcoma (similar fusion genes are also seen in angiomatoid fibrous histiocytoma).

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  • (PMID = 17075294.001).
  • [ISSN] 1072-4109
  • [Journal-full-title] Advances in anatomic pathology
  • [ISO-abbreviation] Adv Anat Pathol
  • [Language] eng
  • [Publication-type] Biography; Historical Article; Journal Article; Portraits; Review
  • [Publication-country] United States
  • [Number-of-references] 33
  • [Personal-name-as-subject] Enzinger F
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28. Shao L, Singh V, Cooley L: Angiomatoid fibrous histiocytoma with t(2;22)(q33;q12.2) and EWSR1 gene rearrangement. Pediatr Dev Pathol; 2009 Mar-Apr;12(2):143-6
Genetic Alliance. consumer health - Histiocytoma, angiomatoid fibrous.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiomatoid fibrous histiocytoma with t(2;22)(q33;q12.2) and EWSR1 gene rearrangement.
  • Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumor of low malignant potential.
  • Histologically, the tumor forms lobulated sheets of plump round to spindle cells surrounded by a fibrous pseudocapsule and lymphoid cuff.
  • [MeSH-major] Calmodulin-Binding Proteins / genetics. Chromosomes, Human, Pair 2 / genetics. Chromosomes, Human, Pair 22 / genetics. Gene Rearrangement. Histiocytoma, Malignant Fibrous / genetics. RNA-Binding Proteins / genetics. Soft Tissue Neoplasms / genetics. Translocation, Genetic

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  • (PMID = 18666823.001).
  • [ISSN] 1093-5266
  • [Journal-full-title] Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
  • [ISO-abbreviation] Pediatr. Dev. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CREB1 protein, human; 0 / Calmodulin-Binding Proteins; 0 / Cyclic AMP Response Element-Binding Protein; 0 / EWSR1 protein, human; 0 / RNA-Binding Proteins
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29. Ajlan AM, Sayegh K, Powell T, David H, Riha RM, Khan J, Nahal A: Angiomatoid fibrous histiocytoma: magnetic resonance imaging appearance in 2 cases. J Comput Assist Tomogr; 2010 Sep-Oct;34(5):791-4
MedlinePlus Health Information. consumer health - MRI Scans.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiomatoid fibrous histiocytoma: magnetic resonance imaging appearance in 2 cases.
  • OBJECTIVE: Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumor usually affecting the extremities of children and young adults and has a favorable prognosis.
  • CONCLUSIONS: Although the overall features of AFH can be confused with other subtypes of malignant fibrous histiocytoma, the young age at presentation, the location of the mass, the presence of intralesional blood-filled cystic spaces with fluid-fluid levels, associated features of hemosiderin deposition, and an enhancing fibrous pseudocapsule are all potential hints favoring this entity.
  • [MeSH-major] Histiocytoma, Benign Fibrous / diagnosis. Magnetic Resonance Imaging / methods. Soft Tissue Neoplasms / diagnosis

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  • (PMID = 20861788.001).
  • [ISSN] 1532-3145
  • [Journal-full-title] Journal of computer assisted tomography
  • [ISO-abbreviation] J Comput Assist Tomogr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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30. Koletsa T, Hytiroglou P, Semoglou C, Drevelegas A, Karkavelas G: Angiomatoid fibrous histiocytoma with cystic structures of sweat duct origin. Pathol Int; 2007 Aug;57(8):513-6
Genetic Alliance. consumer health - Histiocytoma, angiomatoid fibrous.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiomatoid fibrous histiocytoma with cystic structures of sweat duct origin.
  • Angiomatoid fibrous histiocytoma is an unusual soft tissue tumor, mostly arising in the subcutaneous fibro-adipose tissue of children and young adults and measuring a few centimeters in greatest dimension.
  • Reported herein is a unique case of angiomatoid fibrous histiocytoma containing epithelium-lined cystic structures.
  • [MeSH-major] Histiocytoma, Malignant Fibrous / pathology. Neoplasms, Adnexal and Skin Appendage / pathology. Soft Tissue Neoplasms / pathology. Sweat Glands / pathology

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  • (PMID = 17610476.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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31. Ren L, Guo SP, Zhou XG, Chan JK: Angiomatoid fibrous histiocytoma: first report of primary pulmonary origin. Am J Surg Pathol; 2009 Oct;33(10):1570-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiomatoid fibrous histiocytoma: first report of primary pulmonary origin.
  • Angiomatoid fibrous histiocytoma is an uncommon soft tissue tumor most frequently affecting the deep dermis and subcutis of the extremities in children and young adults.
  • Histologically, the tumor was composed of multiple cellular nodules surrounded by a fibrous pseudocapsule and peritumoral lymphoplasmacytic infiltrates.
  • It is important to recognize that angiomatoid fibrous histiocytoma can occur in the lung because its histologic features are rather nondescript and thus can be mistaken for other tumors such as meningioma, inflammatory myofibroblastic tumor, and follicular dendritic cell sarcoma.
  • [MeSH-major] Histiocytoma, Malignant Fibrous / pathology. Lung Neoplasms / pathology

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  • (PMID = 19654501.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / EWS-ATF1 fusion protein, human; 0 / Oncogene Proteins, Fusion; 0 / Transcription Factors
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32. Weinreb I, Rubin BP, Goldblum JR: Pleomorphic angiomatoid fibrous histiocytoma: a case confirmed by fluorescence in situ hybridization analysis for EWSR1 rearrangement. J Cutan Pathol; 2008 Sep;35(9):855-60
Genetic Alliance. consumer health - Histiocytoma, angiomatoid fibrous.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pleomorphic angiomatoid fibrous histiocytoma: a case confirmed by fluorescence in situ hybridization analysis for EWSR1 rearrangement.
  • Angiomatoid fibrous histiocytoma (AFH) is a neoplasm of uncertain histogenesis with intermediate malignant potential.
  • The neoplasm is usually composed of a bland histiocytoid proliferation of cells with eosinophilic cytoplasm forming a syncytium, often surrounded by a dense fibrous pseudocapsule and lymphoid infiltrate, with abundant intralesional hemorrhage forming blood-filled spaces.
  • We present a diagnostically challenging case of AFH with pleomorphic features and minimal lymphoid and angiomatoid changes involving the superficial subcutis and deep dermis on the scalp of an 8-year-old boy.
  • [MeSH-major] Histiocytoma, Malignant Fibrous / pathology. Oncogene Proteins, Fusion / genetics. Soft Tissue Neoplasms / pathology. Transcription Factors / genetics

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  • (PMID = 18422688.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / EWS-ATF1 fusion protein, human; 0 / Oncogene Proteins, Fusion; 0 / RNA-Binding Protein FUS; 0 / Transcription Factors
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33. Lemos MM, Karlen J, Tani E: Fine-needle aspiration cytology of angiomatoid malignant fibrous histiocytoma. Diagn Cytopathol; 2005 Aug;33(2):116-21
Genetic Alliance. consumer health - Histiocytoma, angiomatoid fibrous.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fine-needle aspiration cytology of angiomatoid malignant fibrous histiocytoma.
  • Angiomatoid malignant fibrous histiocytoma (AMFH) is a rare, low-grade malignant mesenchymal neoplasm that affects mostly the extremities of children and young adults.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Muscle Neoplasms / pathology

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  • [Copyright] Copyright 2005 Wiley-Liss, Inc.
  • (PMID = 16007669.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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34. Diebold J, Le Tourneau A, Marmey B, Prevot S, Müller-Hermelink HK, Sevestre H, Molina T, Billotet C, Gaulard P, Knopf JF, Bendjaballah S, Mangnan-Marai A, Brière J, Fabiani B, Audouin J: Is sclerosing angiomatoid nodular transformation (SANT) of the splenic red pulp identical to inflammatory pseudotumour? Report of 16 cases. Histopathology; 2008 Sep;53(3):299-310

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Is sclerosing angiomatoid nodular transformation (SANT) of the splenic red pulp identical to inflammatory pseudotumour? Report of 16 cases.
  • AIMS: To report 16 cases of sclerosing angiomatoid nodular transformation (SANT) of the splenic red pulp.
  • An initial group of seven patients was diagnosed with SANT based on the presence of angiomatoid nodules.
  • Angiomatoid nodules were detected, leading to the diagnosis of SANT in all cases.
  • CONCLUSIONS: SANT of the red pulp is a distinct benign pseudotumorous lesion of the spleen characterized by the presence of angiomatoid nodules.
  • We observed such angiomatoid nodules in all our cases of splenic IPT, which were not follicular dendritic cell or myofibroblastic tumours.
  • We therefore recommend careful examination for angiomatoid nodules in all suspected cases of splenic IPT.
  • [MeSH-major] Granuloma, Plasma Cell / pathology. Histiocytoma, Benign Fibrous / pathology. Spleen / pathology. Splenic Neoplasms / pathology

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  • [CommentIn] Histopathology. 2009 Mar;54(4):494; author reply 494 [19309404.001]
  • (PMID = 18643852.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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35. Karaosmanoglu DA, Karcaaltincaba M, Akata D: CT and MRI findings of sclerosing angiomatoid nodular transformation of the spleen: spoke wheel pattern. Korean J Radiol; 2008 Jul;9 Suppl:S52-5
Hazardous Substances Data Bank. GADOLINIUM, ELEMENTAL .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] CT and MRI findings of sclerosing angiomatoid nodular transformation of the spleen: spoke wheel pattern.
  • Sclerosing angiomatoid nodular transformation of the spleen is a recently described benign pathologic entity that is characterized by round shaped vascular spaces that are lined by endothelial cells, and the spaces are circumscribed by granulomatoid structures.
  • Microscopically, all the reported cases had multiple angiomatoid nodules in a fibrosclerotic stroma.
  • Each angiomatoid nodule was made up of slit-like, round or irregular shaped vascular spaces that were lined by endothelial cells and interspersed ovoid cells.
  • We present here the CT and dynamic gadolinium-enhanced MR findings of a patient with sclerosing angiomatoid nodular transformation.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Histiocytoma, Benign Fibrous / radiography. Magnetic Resonance Imaging. Splenic Neoplasms / pathology. Splenic Neoplasms / radiography. Tomography, X-Ray Computed

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  • MedlinePlus Health Information. consumer health - MRI Scans.
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  • [Cites] Am J Surg Pathol. 2004 Oct;28(10):1268-79 [15371942.001]
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  • (PMID = 18607127.001).
  • [ISSN] 1229-6929
  • [Journal-full-title] Korean journal of radiology
  • [ISO-abbreviation] Korean J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] AU0V1LM3JT / Gadolinium
  • [Other-IDs] NLM/ PMC2627191
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36. Kuo TT, Chen TC, Lee LY: Sclerosing angiomatoid nodular transformation of the spleen (SANT): clinicopathological study of 10 cases with or without abdominal disseminated calcifying fibrous tumors, and the presence of a significant number of IgG4+ plasma cells. Pathol Int; 2009 Dec;59(12):844-50

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sclerosing angiomatoid nodular transformation of the spleen (SANT): clinicopathological study of 10 cases with or without abdominal disseminated calcifying fibrous tumors, and the presence of a significant number of IgG4+ plasma cells.
  • Sclerosing angiomatoid nodular transformation (SANT) is a peculiar splenic vascular lesion that is characterized by marked stromal sclerosis and the presence of plasma cells, which shares histopathological features associated with IgG4-related sclerosing disease.
  • Three cases of SANT had multiple tumors and five had associated abdominal disseminated calcifying fibrous tumors (CFT).
  • IgG4+ plasma cells were found in all of the cases of SANT and in calcifying fibrous tumors.
  • [MeSH-major] Abdominal Neoplasms / pathology. Histiocytoma, Benign Fibrous / pathology. Immunoglobulin G / immunology. Neoplasms, Fibrous Tissue / pathology. Plasma Cells / immunology. Splenic Neoplasms / pathology

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  • (PMID = 20021608.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Immunoglobulin G
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37. Kuybulu A, Sipahi T, Topal I, Uner A: Splenic angiomatoid nodular transformation in a child with increased erythrocyte sedimentation rate. Pediatr Hematol Oncol; 2009 Oct-Nov;26(7):533-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Splenic angiomatoid nodular transformation in a child with increased erythrocyte sedimentation rate.
  • Splenectomy was performed and histopathological examination revealed sclerosing angiomatoid nodular transformation (SANT) of the spleen.
  • [MeSH-major] Histiocytoma, Benign Fibrous / blood. Histiocytoma, Benign Fibrous / pathology. Splenic Neoplasms / blood. Splenic Neoplasms / pathology

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  • (PMID = 19863210.001).
  • [ISSN] 1521-0669
  • [Journal-full-title] Pediatric hematology and oncology
  • [ISO-abbreviation] Pediatr Hematol Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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38. Kashiwagi S, Kumasaka T, Bunsei N, Fukumura Y, Yamasaki S, Abe K, Mitani K, Abe H, Matsumoto T, Suda K: Detection of Epstein-Barr virus-encoded small RNA-expressed myofibroblasts and IgG4-producing plasma cells in sclerosing angiomatoid nodular transformation of the spleen. Virchows Arch; 2008 Sep;453(3):275-82

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Detection of Epstein-Barr virus-encoded small RNA-expressed myofibroblasts and IgG4-producing plasma cells in sclerosing angiomatoid nodular transformation of the spleen.
  • Sclerosing angiomatoid nodular transformation (SANT) of the spleen is a rare inflammatory tumor-like lesion composed of vascular nodules and non-neoplastic stroma including spindle cells and inflammatory cells.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Splenic Neoplasms / pathology

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  • (PMID = 18696108.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Immunoglobulin G; 0 / RNA, Viral
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39. Hou J, Ji Y, Tan YS, Shi DR, Liu YL, Xu C, Zeng HY: [Sclerosing angiomatoid nodular transformation of spleen: a clinicopathologic study of 10 cases with review of literature]. Zhonghua Bing Li Xue Za Zhi; 2010 Feb;39(2):84-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Sclerosing angiomatoid nodular transformation of spleen: a clinicopathologic study of 10 cases with review of literature].
  • OBJECTIVE: To study the clinicopathologic features, differential diagnosis and pathogenesis of sclerosing angiomatoid nodular transformation of spleen.
  • METHODS: Ten cases of sclerosing angiomatoid nodular transformation of spleen were retrieved from the archival file.
  • RESULTS: Sclerosing angiomatoid nodular transformation was characterized by micronodular appearance of vascular spaces lined by plump endothelial cells with interspersed ovoid spindle cells.
  • Immunohistochemical study showed that the endothelial cells of vessels in the angiomatoid nodules had various expressions of immunologic phenotypes and could be mainly classified into 3 types: CD34(+)/CD31(+)/CD8⁻ endothelial cells of the capillaries, CD8(+)/CD31(+)/CD34⁻ lining cells of the sinusoids and CD31(+)/CD8⁻/CD34⁻ endothelial cells of the small veins.
  • CONCLUSIONS: Sclerosing angiomatoid nodular transformation of spleen is a rare benign entity.
  • It needs to be distinguished from borderline or malignant vascular tumors of spleen.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Splenic Neoplasms / pathology

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  • (PMID = 20388372.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Antigens, CD34; 0 / Antigens, CD8
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40. Hartmann M, Marx A, Geissinger E, Müller-Hermelink HK, Rüdiger T: [Vascular proliferations of the spleen]. Pathologe; 2008 Mar;29(2):129-35
MedlinePlus Health Information. consumer health - Birthmarks.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The most common malignant vascular tumours of the spleen are angiosarcomas.
  • A recently described vascular lesion of unknown pathogenesis, sclerosing angiomatoid nodular transformation (SANT) of the spleen, usually is an incidental finding detected in the course of imaging studies.
  • [MeSH-minor] Cell Transformation, Neoplastic / pathology. Diagnosis, Differential. Hamartoma / pathology. Histiocytoma, Benign Fibrous / pathology. Humans. Lymphangioma / pathology. Paraneoplastic Syndromes / pathology. Vascular Diseases / pathology

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  • (PMID = 18214485.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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41. Frampas E, Regenet N, Moreau A, Léauté F, Dupas B: [Sclerosing angiomatoid nodular transformation of the spleen]. J Radiol; 2009 Nov;90(11 Pt 1):1755-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Sclerosing angiomatoid nodular transformation of the spleen].
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Splenic Neoplasms / pathology

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  • (PMID = 19953066.001).
  • [ISSN] 0221-0363
  • [Journal-full-title] Journal de radiologie
  • [ISO-abbreviation] J Radiol
  • [Language] fre
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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42. Nagai Y, Hayama N, Kishimoto T, Furuya M, Takahashi Y, Otsuka M, Miyazaki M, Nakatani Y: Predominance of IgG4+ plasma cells and CD68 positivity in sclerosing angiomatoid nodular transformation (SANT). Histopathology; 2008 Oct;53(4):495-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Predominance of IgG4+ plasma cells and CD68 positivity in sclerosing angiomatoid nodular transformation (SANT).
  • [MeSH-major] Antigens, CD / metabolism. Antigens, Differentiation, Myelomonocytic / metabolism. Histiocytoma, Benign Fibrous / pathology. Immunoglobulin G / metabolism. Plasma Cells / metabolism. Splenic Neoplasms / pathology

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  • (PMID = 18752536.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / CD68 antigen, human; 0 / Immunoglobulin G
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43. Raman SR, Parithivel VS, Niazi M: Image of the month. Sclerosing angiomatoid nodular transformation of the spleen. Arch Surg; 2010 Feb;145(2):205-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Image of the month. Sclerosing angiomatoid nodular transformation of the spleen.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Histiocytoma, Benign Fibrous / radiography. Splenic Neoplasms / pathology. Splenic Neoplasms / radiography

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  • (PMID = 20157091.001).
  • [ISSN] 1538-3644
  • [Journal-full-title] Archives of surgery (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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44. Rosai J: Is sclerosing angiomatoid nodular transformation (SANT) of the splenic red pulp identical to inflammatory pseudotumor? Report of 16 cases. Histopathology; 2009 Mar;54(4):494; author reply 494
MedlinePlus Health Information. consumer health - Spleen Diseases.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Is sclerosing angiomatoid nodular transformation (SANT) of the splenic red pulp identical to inflammatory pseudotumor? Report of 16 cases.
  • [MeSH-major] Granuloma, Plasma Cell / pathology. Histiocytoma, Benign Fibrous / pathology. Splenic Diseases / pathology. Splenic Neoplasms / pathology

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  • [CommentOn] Histopathology. 2008 Sep;53(3):299-310 [18643852.001]
  • (PMID = 19309404.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] England
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45. Lee D, Wood B, Formby M, Cho T: F-18 FDG-avid sclerosing angiomatoid nodular transformation (SANT) of the spleen: case study and literature review. Pathology; 2007 Feb;39(1):181-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] F-18 FDG-avid sclerosing angiomatoid nodular transformation (SANT) of the spleen: case study and literature review.
  • [MeSH-major] Fluorodeoxyglucose F18. Histiocytoma, Benign Fibrous / pathology. Neoplasms, Second Primary / pathology. Splenic Neoplasms / pathology

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  • (PMID = 17365838.001).
  • [ISSN] 0031-3025
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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46. Li L, Fisher DA, Stanek AE: Sclerosing angiomatoid nodular transformation (SANT) of the spleen: addition of a case with focal CD68 staining and distinctive CT features. Am J Surg Pathol; 2005 Jun;29(6):839-41

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sclerosing angiomatoid nodular transformation (SANT) of the spleen: addition of a case with focal CD68 staining and distinctive CT features.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Splenic Neoplasms / pathology

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  • [CommentOn] Am J Surg Pathol. 2004 Oct;28(10):1268-79 [15371942.001]
  • (PMID = 15897756.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Comment; Letter
  • [Publication-country] United States
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