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1. Udhrain A, Skubitz KM, Northfelt DW: Pegylated liposomal doxorubicin in the treatment of AIDS-related Kaposi's sarcoma. Int J Nanomedicine; 2007;2(3):345-52
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  • Kaposi's sarcoma is a vascular tumor of skin and viscera first described in 1872.
  • Compelling preclinical and clinical evidence, reviewed herein, has demonstrated that the nanoparticle (pegylated liposome) delivery system of this formulation leads to greater tumor localization of doxorubicin and consequent improved efficacy, as well as reduced toxicity.

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  • (PMID = 18019833.001).
  • [ISSN] 1176-9114
  • [Journal-full-title] International journal of nanomedicine
  • [ISO-abbreviation] Int J Nanomedicine
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] New Zealand
  • [Chemical-registry-number] 0 / Drug Carriers; 0 / Liposomes; 30IQX730WE / Polyethylene Glycols
  • [Number-of-references] 35
  • [Other-IDs] NLM/ PMC2676669
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2. Chen JH, Wang KH, Hu CH, Chiu JS: Atypical angioma serpiginosum. Yonsei Med J; 2008 Jun 30;49(3):509-13
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  • [Title] Atypical angioma serpiginosum.
  • Angioma serpiginosum is an uncommon, acquired vascular nevoid disorder with capillary dilation and proliferation in the papillary dermis.
  • According to the clinical and pathological findings, we established a diagnosis of angioma serpiginosum.
  • She was treated with a pulsed dye laser, and the angiomatous lesions subsequently improved.
  • [MeSH-major] Skin Diseases, Vascular / diagnosis. Telangiectasis / diagnosis
  • [MeSH-minor] Dermatologic Surgical Procedures. Female. Foot Diseases / diagnosis. Foot Diseases / surgery. Humans. Lasers, Dye / therapeutic use. Middle Aged. Skin / blood supply. Skin / pathology. Treatment Outcome

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  • (PMID = 18581605.001).
  • [ISSN] 0513-5796
  • [Journal-full-title] Yonsei medical journal
  • [ISO-abbreviation] Yonsei Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2615349
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3. Nakamura Y, Nakamagoe K, Kawachi Y, Hosaka A, Mukai H, Chiba S, Otsuka F, Tamaoka A: Intravascular large B cell lymphoma with neurological symptoms diagnosed on the basis of a senile angioma-like eruption. BMJ Case Rep; 2009;2009
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intravascular large B cell lymphoma with neurological symptoms diagnosed on the basis of a senile angioma-like eruption.
  • Intravascular large B cell lymphoma (IVLBCL) presents various neurological symptoms, and the prognosis frequently deteriorates with a delay in diagnosis.
  • In addition, for the diagnosis of IVLBCL, invasive biopsies are generally performed in main organs, such as the brain.
  • We report a case of IVLBCL in which an early diagnosis was enabled by skin biopsy.
  • At the macroscopic level, her lesions resembled senile angioma, commonly observed in normal elderly persons.
  • In cases in which IVLBCL could be suspected, an active search and biopsy of skin lesions, including an eruption of this type, are useful for early diagnosis and treatment.

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  • (PMID = 21686374.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3029526
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4. Rader C, Piorkowski J, Bass DM, Babigian A: Epulis gravidarum manum: pyogenic granuloma of the hand occurring in pregnant women. J Hand Surg Am; 2008 Feb;33(2):263-5
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  • Pyogenic granuloma, also known as lobular capillary hemangioma, is a benign vascular tumor of the skin and mucous membranes.
  • These tumors failed to resolve spontaneously postpartum necessitating surgical removal.
  • We propose the term epulis gravidarum manum to describe this skin lesion.
  • [MeSH-major] Granuloma, Pyogenic / pathology. Hand / pathology. Pregnancy Complications / pathology. Skin Diseases / pathology

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  • (PMID = 18294552.001).
  • [ISSN] 0363-5023
  • [Journal-full-title] The Journal of hand surgery
  • [ISO-abbreviation] J Hand Surg Am
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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5. Haddy N, Dondon MG, Paoletti C, Rubino C, Mousannif A, Shamsaldin A, Doyon F, Labbé M, Robert C, Avril MF, Demars R, Molinie F, Lefkopoulos D, Diallo I, de Vathaire F: Breast cancer following radiotherapy for a hemangioma during childhood. Cancer Causes Control; 2010 Nov;21(11):1807-16
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  • [Title] Breast cancer following radiotherapy for a hemangioma during childhood.
  • PURPOSE: A cohort study was performed to investigate the carcinogenic effect of treatment of skin hemangioma with ionizing radiation in early childhood.
  • METHODS AND MATERIALS: In an incidence study, 3,316 women treated for a skin hemangioma between 1941 and 1977 at the Institut Gustave-Roussy were included, among whom 2,697 had received radiotherapy.
  • CONCLUSION: This study confirms that radiation treatment performed in the past for hemangioma during childhood increases the risk of BC.
  • [MeSH-major] Breast Neoplasms / epidemiology. Breast Neoplasms / etiology. Hemangioma / radiotherapy. Neoplasms, Radiation-Induced / etiology. Skin Neoplasms / radiotherapy


6. Uthup S, Balachandran K, Ammal VA, Abdul Salam R, George J, Nair GM, Leela M: Renal involvement in multicentric Castleman disease with glomeruloid hemangioma of skin and plasmacytoma. Am J Kidney Dis; 2006 Aug;48(2):e17-24
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  • [Title] Renal involvement in multicentric Castleman disease with glomeruloid hemangioma of skin and plasmacytoma.
  • He had left-sided pleural effusion, generalized lymphadenopathy, multiple nontender cutaneous nodules, hepatomegaly, renal failure, and hypergammaglobulinemia.
  • Axillary lymph node biopsy showed findings consistent with Castleman disease of the hyaline vascular type associated with interfollicular plasmacytosis.
  • Skin nodule biopsy showed a glomeruloid hemangioma characterized by dermal proliferation of capillary loops in a nodular manner resembling a glomerulus.
  • To our knowledge, this is the first case report of the occurrence of membranoproliferative glomerulonephritis, glomeruloid hemangioma of the skin, and plasmacytoma in a patient with multicentric Castleman disease without human immunodeficiency virus infection.
  • [MeSH-major] Giant Lymph Node Hyperplasia / complications. Glomerulonephritis, Membranoproliferative / etiology. Hemangioma / etiology. Plasmacytoma / etiology. Skin Neoplasms / etiology

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  • (PMID = 16860182.001).
  • [ISSN] 1523-6838
  • [Journal-full-title] American journal of kidney diseases : the official journal of the National Kidney Foundation
  • [ISO-abbreviation] Am. J. Kidney Dis.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Immunosuppressive Agents; 0 / Steroids; 8N3DW7272P / Cyclophosphamide
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7. Pascual-Castroviejo I, Pascual-Pascual SI, Velázquez-Fragua R, García L, López-Gutiérrez JC, Viaño-López J, Martínez V, Palencia R: [Cutaneous hemangiomas and vascular malformations and associated pathology (Pascual-Castroviejo type II syndrome). Study of 41 patients]. Rev Neurol; 2005 Aug 16-31;41(4):223-36
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  • [Title] [Cutaneous hemangiomas and vascular malformations and associated pathology (Pascual-Castroviejo type II syndrome). Study of 41 patients].
  • [Transliterated title] Hemangiomas y malformaciones vasculares cutáneas y patología asociada (síndrome de Pascual-Castroviejo tipo II). Presentación de 41 pacientes.
  • AIM: To describe the clinical, diagnostic and therapeutic features of this angiomatous neurocutaneous syndrome, which is the most frequent one, and to report a personal series of 41 patients.
  • The cutaneous lesions were classified as hemangiomas in 30 patients (73%) and as vascular malformations in 11 patients (27%).
  • The most frequent abnormalities were intracranial and/or extracranial vascular malformations.
  • Also were observed 4 patients (10%) with intracranial hemangioma, 2 (5%) with hemangioma in mediastinum, and 3 (7.5%) with intestinal hemangioma, all of which disappeared during the first years of life.
  • At the same time the cutaneous hemangioma regressed.
  • CONCLUSION: This neurocutaneous syndrome is the most frequent one and it is associated with several types of vascular and non-vascular abnormalities which can involve any organ of the body.
  • Internal and external hemangiomas and hemangiomatous lesions progress and tend to regress concomitantly.
  • [MeSH-major] Cardiovascular Abnormalities / pathology. Hemangioma / pathology. Neurocutaneous Syndromes / pathology. Skin Diseases, Vascular / pathology. Skin Neoplasms / pathology


8. Yuan RT, Jia MY, Feng YY, Shang W, Li NY: [Early laser intervention of hemangioma in facial and neck regions of infant]. Hua Xi Kou Qiang Yi Xue Za Zhi; 2008 Apr;26(2):166-7, 171
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  • [Title] [Early laser intervention of hemangioma in facial and neck regions of infant].
  • OBJECTIVE: The study was to evaluate the method of early laser intervention of hemangioma in facial and neck regions of infant.
  • METHODS: Between January 1999 and December 2006, twelve patients, aged 6 days to 3 months, with cutaneous hemangioma in facial and neck regions, were treated with laser, eight cases with Nd:YAG laser therapy and four cases with Venus laser therapy.
  • Four cases with hemangioma in facial and neck regions of infant treated with oral corticosteroid were as control.
  • Hemangiomas enlarged continuously in four cases with oral corticosteroid therapy.
  • CONCLUSION: Early laser intervention is an excellent management of cutaneous hemangioma in facial and neck regions of infant.
  • [MeSH-major] Hemangioma. Neck

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  • (PMID = 18605456.001).
  • [ISSN] 1000-1182
  • [Journal-full-title] Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology
  • [ISO-abbreviation] Hua Xi Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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9. Rahman M, Rahman S, Rahman M, Akhter S, Kawser C: Overlapping of Sturge Weber syndrome and Klippel Trenaunay Weber syndrome. Mymensingh Med J; 2008 Jan;17(1):78-81
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  • The reported case had seizures, port wine haemangioma of the right side of the body, glaucoma of both eyes, subcortical calcification which were consistent with the Sturge Weber Syndrome; on the other hand he had also hypertrophy of the right side of the including the face and limbs, angiomatous skin naevus, varicosities consistent with the KTWS.

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  • (PMID = 18285739.001).
  • [ISSN] 1022-4742
  • [Journal-full-title] Mymensingh medical journal : MMJ
  • [ISO-abbreviation] Mymensingh Med J
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Bangladesh
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10. Haddy N, Andriamboavonjy T, Paoletti C, Dondon MG, Mousannif A, Shamsaldin A, Doyon F, Labbé M, Robert C, Avril MF, Fragu P, Eschwege F, Chavaudra J, Schvartz C, Lefkopoulos D, Schlumberger M, Diallo I, de Vathaire F: Thyroid adenomas and carcinomas following radiotherapy for a hemangioma during infancy. Radiother Oncol; 2009 Nov;93(2):377-82
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  • [Title] Thyroid adenomas and carcinomas following radiotherapy for a hemangioma during infancy.
  • BACKGROUND AND PURPOSE: A cohort study was performed to investigate the carcinogenic effect of treating skin hemangioma with ionizing radiation during early childhood.
  • METHODS AND MATERIALS: Of a total of 8307 patients treated for a skin hemangioma between 1940 and 1973 at the Institut Gustave-Roussy, 4767 were included in an incidence study, among whom 3795 had received radiotherapy.
  • Thyroid tumor cases were obtained by sending out a questionnaire, and were verified in pathological reports.
  • CONCLUSION: This study confirms that radiation treatment performed in the past for hemangioma during infancy increased the risk of thyroid carcinoma and adenoma.
  • Patients treated with external radiotherapy or with Radium 226 applicators for hemangiomas have to be more specifically followed up because this is the subgroup in whom the highest doses were received by the thyroid gland (more than 90% of the radiation doses were higher than 100 mGy).
  • [MeSH-major] Hemangioma / radiotherapy. Neoplasms, Radiation-Induced / etiology. Neoplasms, Second Primary / etiology. Thyroid Neoplasms / etiology

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  • (PMID = 19515442.001).
  • [ISSN] 1879-0887
  • [Journal-full-title] Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
  • [ISO-abbreviation] Radiother Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] W90AYD6R3Q / Radium
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11. Holmberg E, Anderson H, Lundell M, Karlsson P: The impact of reproductive factors on breast cancer risk--the feasibility of using Swedish population-based registers to account for the effect of confounding in cohort studies. Cancer Causes Control; 2005 Apr;16(3):235-43
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In a sub-cohort of 18,164 women irradiated for skin hemangioma in infancy, the breast cancer risk was analyzed in relation to radiation dose and accounting for reproductive factors.
  • The discrepancies of reproductive factors in the hemangioma cohort compared to Swedish women had a minor effect on RR, with a reduction from 1.13 (95%CI 1.00--1.26) to 1.11 (95% CI 0.99--1.25).
  • [MeSH-minor] Age Factors. Aged. Aged, 80 and over. Cohort Studies. Confounding Factors (Epidemiology). Female. Hemangioma / radiotherapy. Humans. Middle Aged. Skin Neoplasms / radiotherapy. Sweden / epidemiology

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  • (PMID = 15947875.001).
  • [ISSN] 0957-5243
  • [Journal-full-title] Cancer causes & control : CCC
  • [ISO-abbreviation] Cancer Causes Control
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
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12. Poenitz N, Koenen W, Utikal J, Goerdt S: [Angioma serpiginosum following the lines of Blaschko--an effective treatment with the IPL technology]. J Dtsch Dermatol Ges; 2006 Aug;4(8):650-3
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  • [Title] [Angioma serpiginosum following the lines of Blaschko--an effective treatment with the IPL technology].
  • [Transliterated title] Angioma serpiginosum in den Blaschkolinien--eine effektive Behandlung mit der IPL Technik.
  • Angioma serpiginosum, first described by Hutchinson in 1889, is a rare benign vascular nevus with dilatation and proliferation of the capillaries in the upper dermis.
  • A 15-year-old boy presented with an angioma serpiginosum on the right side of the body following the lines of Blaschko.
  • [MeSH-major] Hemangioma / pathology. Hemangioma / therapy. Phototherapy / methods. Skin Neoplasms / pathology. Skin Neoplasms / therapy

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  • (PMID = 16895567.001).
  • [ISSN] 1610-0379
  • [Journal-full-title] Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
  • [ISO-abbreviation] J Dtsch Dermatol Ges
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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13. Schaffer JV, Fangman W, Bossenbroek NM, Meehan SA, Kamino H: Tufted angioma. Dermatol Online J; 2008;14(10):20
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  • [Title] Tufted angioma.
  • Histopathologic evaluation showed multiple, discrete lobules of tightly packed capillaries in a 'cannonball' pattern within the dermis, which confirmed the diagnosis of tufted angioma.
  • [MeSH-major] Hemangioma / diagnosis. Skin Neoplasms / diagnosis


14. Browning J, Frieden I, Baselga E, Wagner A, Metry D: Congenital, self-regressing tufted angioma. Arch Dermatol; 2006 Jun;142(6):749-51
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  • [Title] Congenital, self-regressing tufted angioma.
  • BACKGROUND: Tufted angioma (known in Japanese literature as angioblastoma of Nakagawa) is an uncommon, histologically benign, vascular tumor.
  • OBSERVATIONS: We present a series of 5 histopathologically confirmed cases of congenital tufted angioma that spontaneously regressed during infancy or early childhood.
  • CONCLUSION: We recommend that observation for potential regression be considered for otherwise uncomplicated congenital or early infantile cases of tufted angioma.
  • [MeSH-major] Hemangioma, Capillary / diagnosis. Neoplasm Regression, Spontaneous / pathology. Skin Neoplasms / diagnosis
  • [MeSH-minor] Arm. Cheek. Diagnosis, Differential. Female. Forearm. Forehead. Humans. Infant. Infant, Newborn. Male. Shoulder

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  • (PMID = 16785378.001).
  • [ISSN] 0003-987X
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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15. Namazi MR, Maghsoodi M: Association of angiokeratoma of the vulva with angioma serpiginosum. J Drugs Dermatol; 2008 Sep;7(9):882-3
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  • [Title] Association of angiokeratoma of the vulva with angioma serpiginosum.
  • Angioma serpiginosum is a rare benign vascular disorder usually beginning in childhood.
  • [MeSH-major] Angiokeratoma / pathology. Hemangioma / pathology. Vulvar Neoplasms / pathology
  • [MeSH-minor] Adult. Buttocks / pathology. Female. Humans. Skin Neoplasms / complications. Skin Neoplasms / pathology

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  • (PMID = 19112804.001).
  • [ISSN] 1545-9616
  • [Journal-full-title] Journal of drugs in dermatology : JDD
  • [ISO-abbreviation] J Drugs Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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16. Sandhu K, Gupta S: Angioma serpiginosum: report of two unusual cases. J Eur Acad Dermatol Venereol; 2005 Jan;19(1):127-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angioma serpiginosum: report of two unusual cases.
  • Angioma serpiginosum (AS) is a rare vascular naevoid disorder due to ectatic dilation of capillaries in the papillary dermis.
  • [MeSH-major] Skin Diseases, Vascular / diagnosis. Telangiectasis / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Leg. Thorax

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  • (PMID = 15649209.001).
  • [ISSN] 0926-9959
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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17. Bayramgurler D, Filinte D, Kiran R: Angioma serpiginosum with sole involvement. Eur J Dermatol; 2008 Nov-Dec;18(6):708-9
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  • [Title] Angioma serpiginosum with sole involvement.
  • Angioma serpiginosum, which is characterized by multiple, minute, angiomatous puncta, is mainly located on the lower extremities of girls under the age of 16.
  • Increased levels of estrogens have been proposed in the development of angioma serpiginosum.
  • [MeSH-major] Foot Diseases / pathology. Skin Diseases, Vascular / pathology
  • [MeSH-minor] Adolescent. Female. Humans. Skin / pathology

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  • (PMID = 18955205.001).
  • [ISSN] 1167-1122
  • [Journal-full-title] European journal of dermatology : EJD
  • [ISO-abbreviation] Eur J Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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18. Arai E, Kuramochi A, Tsuchida T, Tsuneyoshi M, Kage M, Fukunaga M, Ito T, Tada T, Izumi M, Shimizu K, Hirose T, Shimizu M: Usefulness of D2-40 immunohistochemistry for differentiation between kaposiform hemangioendothelioma and tufted angioma. J Cutan Pathol; 2006 Jul;33(7):492-7
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  • [Title] Usefulness of D2-40 immunohistochemistry for differentiation between kaposiform hemangioendothelioma and tufted angioma.
  • Our objective was to elucidate, using D2-40 immunohistochemistry, the differences among capillary hemangiomas, and especially between kaposiform hemangioendothelioma (KHE) and tufted angioma (TA).
  • We studied four cases of KHE, nine cases of TA, and 31 cases of other vascular tumors.
  • [MeSH-major] Antibodies, Monoclonal / immunology. Biomarkers, Tumor / immunology. Hemangioendothelioma / diagnosis. Hemangioma / diagnosis. Sarcoma, Kaposi / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Antibodies, Monoclonal, Murine-Derived. Capillaries. Diagnosis, Differential. Humans. Immunohistochemistry. Retrospective Studies


19. Casanova D, Norat F, Bardot J, Magalon G: [Cutaneous hemangioma: clinical aspects]. Ann Chir Plast Esthet; 2006 Aug-Oct;51(4-5):287-92
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  • [Title] [Cutaneous hemangioma: clinical aspects].
  • Infantile cutaneous hemangioma is a benign vascular tumour present at 10% of the infants.
  • It forms part of the group of the vascular tumours in the classification of International Society for Vascular Anomalies (ISSVA).
  • Clinical diagnosis is easy in its triphasic typical form with a phase of sometimes brutal postnatal growth, a phase of stabilization and a phase of slow secondary regression.
  • Classically, it is presented in the form of a mass or stains cutaneous red, of a subcutaneous mass or, generally, of a mixed form associating the two aspects.
  • [MeSH-major] Hemangioma / physiopathology. Skin Neoplasms / physiopathology
  • [MeSH-minor] Child, Preschool. Humans. Infant. Neovascularization, Pathologic / physiopathology. Remission, Spontaneous. Soft Tissue Neoplasms / classification. Soft Tissue Neoplasms / diagnosis. Soft Tissue Neoplasms / physiopathology

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  • (PMID = 16997447.001).
  • [ISSN] 0294-1260
  • [Journal-full-title] Annales de chirurgie plastique et esthétique
  • [ISO-abbreviation] Ann Chir Plast Esthet
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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20. Ramesh R, De Silva B, Atherton DJ: Congenital tufted angioma with persistent low-grade coagulopathy. Clin Exp Dermatol; 2009 Dec;34(8):e766-8
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  • [Title] Congenital tufted angioma with persistent low-grade coagulopathy.
  • A female infant, born with a tufted angioma, developed a coagulopathy with prolonged bleeding time, with the risk of progression to Kasabach-Merritt phenomenon.
  • [MeSH-major] Hemangioma / pathology. Skin Neoplasms / pathology

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  • (PMID = 19778314.001).
  • [ISSN] 1365-2230
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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21. Chen W, Liu TJ, Yang YC, Happle R: Angioma serpiginosum arranged in a systematized segmental pattern suggesting mosaicism. Dermatology; 2006;213(3):236-8
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  • [Title] Angioma serpiginosum arranged in a systematized segmental pattern suggesting mosaicism.
  • Histopathological examination showed dilated capillaries in the uppermost part of the dermal papillae characteristic of angioma serpiginosum.
  • The systematized, segmental and asymmetric arrangement of lesions as noted in the present case suggest that angioma serpiginosum reflects genetic mosaicism.
  • [MeSH-major] Mosaicism. Skin Diseases, Vascular / diagnosis. Telangiectasis / diagnosis

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  • (PMID = 17033175.001).
  • [ISSN] 1018-8665
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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22. Kalisiak MS, Haber RM: Angioma serpiginosum with linear distribution: case report and review of the literature. J Cutan Med Surg; 2008 Jul-Aug;12(4):180-3
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  • [Title] Angioma serpiginosum with linear distribution: case report and review of the literature.
  • BACKGROUND: Angioma serpiginosum is a vascular anomaly that classically presents in childhood and predominantly affects females.
  • OBJECTIVE: To present a case of a young woman with linear distribution of angioma serpiginosum and review the common clinical characteristics and presentation of this condition.
  • METHODS: Case report with skin biopsies and dermoscopic findings.
  • The histopathologic findings of dilated blood vessels in the papillary dermis with absence of other changes confirmed the diagnosis of angioma serpiginosum.
  • CONCLUSION: Angioma serpiginosum is a rare entity that can be distinguished by clinical and histopathologic examinations.
  • [MeSH-major] Hemangioma / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adult. Arm. Biopsy. Diagnosis, Differential. Female. Humans

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  • (PMID = 18627698.001).
  • [ISSN] 1203-4754
  • [Journal-full-title] Journal of cutaneous medicine and surgery
  • [ISO-abbreviation] J Cutan Med Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 19
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23. Le Huu AR, Jokinen CH, Rubin BP, Mihm MC, Weiss SW, North PE, Dadras SS: Expression of prox1, lymphatic endothelial nuclear transcription factor, in Kaposiform hemangioendothelioma and tufted angioma. Am J Surg Pathol; 2010 Nov;34(11):1563-73
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  • [Title] Expression of prox1, lymphatic endothelial nuclear transcription factor, in Kaposiform hemangioendothelioma and tufted angioma.
  • Kaposiform hemangioendothelioma (KHE) and tufted angioma (TA) are rare tumors mainly occurring in early childhood.
  • This dramatic Prox1-induced phenotype prompted us to investigate immunohistochemical staining pattern of Prox1, podoplanin (D2-40), LYVE-1, and Prox1/CD34 as well as double immunofluorescent staining pattern of LYVE-1/CD31 in KHE and TA, compared with other pediatric vascular tumors.
  • For this purpose, we examined 75 vascular lesions: KHE (n=18), TA (n=13), infantile hemangioma (n=13), pyogenic granuloma (n=18), and granulation tissue (n=13).
  • The lesional cells of all infantile hemangiomas and pyogenic granulomas were negative for Prox1 in the presence of positive internal control.
  • Overall, our results show, for the first time, that Prox1 is an immunohistochemical biomarker helpful in confirming the diagnosis of KHE/TA and in distinguishing it from infantile hemangioma and pyogenic granuloma.
  • [MeSH-major] Biomarkers, Tumor / analysis. Hemangioendothelioma / chemistry. Hemangioma / chemistry. Homeodomain Proteins / analysis. Skin Neoplasms / chemistry. Soft Tissue Neoplasms / chemistry. Tumor Suppressor Proteins / analysis
  • [MeSH-minor] Adolescent. Antigens, CD31 / analysis. Antigens, CD34 / analysis. Cell Nucleus / chemistry. Child. Child, Preschool. Cytoplasm / chemistry. Diagnosis, Differential. Granuloma, Pyogenic / metabolism. Humans. Immunohistochemistry. Immunophenotyping. Infant. Membrane Glycoproteins / analysis. Predictive Value of Tests. Vesicular Transport Proteins / analysis

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  • [ErratumIn] Am J Surg Pathol. 2011 Feb;35(2):314. Ruben, Brian P [corrected to Rubin, Brian P]
  • (PMID = 20975337.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Antigens, CD34; 0 / Biomarkers, Tumor; 0 / Homeodomain Proteins; 0 / LYVE1 protein, human; 0 / Membrane Glycoproteins; 0 / PDPN protein, human; 0 / Tumor Suppressor Proteins; 0 / Vesicular Transport Proteins; 0 / prospero-related homeobox 1 protein
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24. Ilknur T, Fetil E, Akarsu S, Altiner DD, Ulukuş C, Güneş AT: Angioma serpiginosum: dermoscopy for diagnosis, pulsed dye laser for treatment. J Dermatol; 2006 Apr;33(4):252-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angioma serpiginosum: dermoscopy for diagnosis, pulsed dye laser for treatment.
  • Angioma serpiginosum is a rare benign vascular disorder, characterized clinically by multiple minute, red to purple, grouped macules in serpiginous and gyrate patterns and histopathologically by ectatic dilatation of capillaries.
  • An 18-year-old man with angioma serpiginosum of his left arm was evaluated by dermoscopy and treated with pulsed dye laser.
  • Our case supports the hypothesis that dermoscopy is beneficial in the diagnosis of angioma serpiginosum and that pulsed dye laser is effective in the treatment of this disorder.
  • [MeSH-major] Hemangioma / pathology. Hemangioma / radiotherapy. Skin Neoplasms / pathology. Skin Neoplasms / radiotherapy

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  • (PMID = 16674788.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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25. Gil C, Bellefleur JP, Vellin A, Leone M, Martin C: [Epidural analgesia and cutaneous angioma: need to perform MRI]. Ann Fr Anesth Reanim; 2010 Jan;29(1):48-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Epidural analgesia and cutaneous angioma: need to perform MRI].
  • [Transliterated title] Anesthésie par voie péridurale et angiomes cutanés : y-a-t-il un intérêt à la réalisation d'une IRM?
  • We wonder whether the use of magnetic resonance imaging (MRI) may be relevant for the detection of spinal angiomas in case of cutaneous angiomas.
  • The likelihood of finding a spinal angioma with MRI is low and the modus operandi is infrequently modified.
  • We report here a case of parturient with a cutaneous median angioma in the lumbar region, which was detected by MRI.
  • [MeSH-major] Analgesia, Epidural / methods. Analgesia, Obstetrical / methods. Hemangioma / pathology. Magnetic Resonance Imaging. Skin Neoplasms / pathology. Unnecessary Procedures

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  • [Copyright] Copyright 2009 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20080013.001).
  • [ISSN] 1769-6623
  • [Journal-full-title] Annales françaises d'anesthèsie et de rèanimation
  • [ISO-abbreviation] Ann Fr Anesth Reanim
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 8
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26. Cheah S, DeKoven J: Pyogenic granuloma complicating pulsed-dye laser therapy for cherry angioma. Australas J Dermatol; 2009 May;50(2):141-3
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  • [Title] Pyogenic granuloma complicating pulsed-dye laser therapy for cherry angioma.
  • A 37 year-old-woman presented for cosmetic removal of a 7-mm (diameter) cherry angioma on her right anterior thigh.
  • Histopathological examination confirmed the diagnosis of pyogenic granuloma.
  • [MeSH-major] Granuloma, Pyogenic / etiology. Hemangioma / surgery. Lasers, Dye / adverse effects. Skin Diseases / etiology. Skin Neoplasms / surgery


27. Chiu CS, Yang LC, Hong HS, Kuan YZ: Treatment of a tufted angioma with intense pulsed light. J Dermatolog Treat; 2007;18(2):109-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Treatment of a tufted angioma with intense pulsed light.
  • Tufted angioma is a rare cutaneous angiomatous proliferation named because of its characteristic histologic pattern of grouped dermal capillary tufts.
  • We report an adult case of tufted angioma, with unusual presentation as annular plaques, which was alleviated after treatment with intense pulsed light in terms of both cosmetics and discomfort.
  • [MeSH-major] Hemangioma / diagnosis. Hemangioma / therapy. Skin Neoplasms / diagnosis. Skin Neoplasms / therapy
  • [MeSH-minor] Adult. Back / pathology. Diagnosis, Differential. Female. Humans. Neck / pathology. Phototherapy. Scalp / pathology

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  • (PMID = 17520468.001).
  • [ISSN] 0954-6634
  • [Journal-full-title] The Journal of dermatological treatment
  • [ISO-abbreviation] J Dermatolog Treat
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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28. Woldemeskel M, Rajeev S: Mast cells in canine cutaneous hemangioma, hemangiosarcoma and mammary tumors. Vet Res Commun; 2010 Feb;34(2):153-60
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  • [Title] Mast cells in canine cutaneous hemangioma, hemangiosarcoma and mammary tumors.
  • Mast cell count (MCC) in 45 dogs with cutaneous hemangioma (HA, n = 12), hemangiosarcoma (HSA, n = 12), mammary adenoma (AD, n = 9) and mammary adenocarcinoma (AC, n = 12) was made using Toluidine blue stained sections.
  • This study suggests that mast cells may play an important role in neovascularization of canine cutaneous vascular and mammary neoplasms.
  • [MeSH-major] Dog Diseases / pathology. Hemangioma / veterinary. Hemangiosarcoma / veterinary. Mammary Neoplasms, Animal / pathology. Mast Cells / pathology. Mastocytosis / veterinary. Skin Neoplasms / veterinary
  • [MeSH-minor] Adenocarcinoma / blood supply. Adenocarcinoma / pathology. Adenocarcinoma / veterinary. Adenoma / blood supply. Adenoma / pathology. Adenoma / veterinary. Animals. Cell Count / veterinary. Dogs. Factor VIII / metabolism. Female. Immunohistochemistry / veterinary. Neovascularization, Pathologic / metabolism. Neovascularization, Pathologic / pathology. Neovascularization, Pathologic / veterinary. Vascular Endothelial Growth Factor A / metabolism

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  • [Cites] J Clin Pathol. 2001 Dec;54(12):940-4 [11729214.001]
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  • (PMID = 20127412.001).
  • [ISSN] 1573-7446
  • [Journal-full-title] Veterinary research communications
  • [ISO-abbreviation] Vet. Res. Commun.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Vascular Endothelial Growth Factor A; 9001-27-8 / Factor VIII
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29. Alberola FT, Betlloch I, Montero LC, Nortes IB, Martínez NL, Paz AM: Congenital tufted angioma: Case report and review of the literature. Dermatol Online J; 2010;16(5):2
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  • [Title] Congenital tufted angioma: Case report and review of the literature.
  • Tufted angiomas (TA) are rare benign vascular tumors of unknown pathogenesis.
  • The differential diagnosis includes infantile hemangiomas, congenital hemangiomas, kaposiform hemangioendothelioma and vascular malformations.
  • [MeSH-major] Hemangioma / congenital. Skin Neoplasms / congenital
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Infant

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  • (PMID = 20492819.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 24
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30. Jalil S, Akhtar J, Ahmed S: Corticosteroids therapy in the management of infantile cutaneous hemangiomas. J Coll Physicians Surg Pak; 2006 Oct;16(10):662-5
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  • [Title] Corticosteroids therapy in the management of infantile cutaneous hemangiomas.
  • OBJECTIVE: To determine the effectiveness of systemic and intra-lesional corticosteroids, in the management of infantile cutaneous hemangiomas and to compare the results with untreated lesions.
  • PATIENTS AND METHODS: A total of 75 cases with cutaneous hemangiomas were included in the study.
  • CONCLUSION: Hemangiomas when left untreated behave in an unpredictable manner.
  • [MeSH-major] Glucocorticoids / administration & dosage. Hemangioma / drug therapy. Skin Neoplasms / drug therapy

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  • (PMID = 17007757.001).
  • [ISSN] 1022-386X
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] Pakistan
  • [Chemical-registry-number] 0 / Glucocorticoids; 1ZK20VI6TY / Triamcinolone
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31. Senchak AJ, Dann M, Cable B, Bessinger G: Successful treatment of cutaneous hemangioma of infancy with topical imiquimod 5%: a report of 3 cases. Ear Nose Throat J; 2010 Mar;89(3):E21-5
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  • [Title] Successful treatment of cutaneous hemangioma of infancy with topical imiquimod 5%: a report of 3 cases.
  • Hemangioma of infancy is the most common benign tumor of childhood.
  • Most of these tumors spontaneously regress over several years.
  • However, many parents seek treatment for children with cutaneous hemangiomas because of the potential for disfigurement and the attendant psychosocial effects.
  • We report our use of the nightly application of topical imiquimod 5% cream as an alternative to traditional management in 3 infants who presented with rapidly growing facial hemangiomas.
  • Based on our experience, we believe that topical imiquimod may be an important tool for the otolaryngologist who treats cutaneous hemangiomas.
  • [MeSH-major] Aminoquinolines / therapeutic use. Antineoplastic Agents / therapeutic use. Hemangioma / drug therapy. Hemangioma / pathology. Skin Neoplasms / drug therapy. Skin Neoplasms / pathology

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  • (PMID = 20229466.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Aminoquinolines; 0 / Antineoplastic Agents; 99011-02-6 / imiquimod
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32. Stockman A, Boralevi F, Taïeb A, Léauté-Labrèze C: SACRAL syndrome: spinal dysraphism, anogenital, cutaneous, renal and urologic anomalies, associated with an angioma of lumbosacral localization. Dermatology; 2007;214(1):40-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] SACRAL syndrome: spinal dysraphism, anogenital, cutaneous, renal and urologic anomalies, associated with an angioma of lumbosacral localization.
  • BACKGROUND: Publications concerning perineal infantile hemangiomas are scarce, and comprise no large series.
  • OBJECTIVE: Studying clinical features of hemangiomas of the perineal area, complications and associated malformations.
  • METHODS: Retrospective analysis of all hemangiomas localized in the perineal area, encountered at the Children's Hospital in Bordeaux from 1994.
  • RESULTS: Of 49 perineal hemangiomas (34 girls, 15 boys), 5 patients had accompanying malformation, mainly lipomyelomeningocele with tethered cord.
  • The superficial hemangiomas were more represented in males and presented sooner than the nodular counterpart.
  • CONCLUSION: Superficial perineal hemangiomas are more often complicated by ulceration, and are associated with developmental anomalies.
  • As a counterpart for the PHACE syndrome in facial hemangioma, we propose the acronym SACRAL for perineal hemangiomas: Spinal dysraphism, Anogenital anomalies, Cutaneous anomalies, Renal and urologic anomalies, associated with Angioma of Lumbosacral localization.
  • [MeSH-major] Anal Canal / abnormalities. Hemangioma / complications. Skin Abnormalities / complications. Spinal Dysraphism / complications. Urogenital Abnormalities / complications
  • [MeSH-minor] Diagnosis, Differential. Female. France / epidemiology. Humans. Incidence. Infant. Infant, Newborn. Lumbosacral Plexus. Male. Perineum. Retrospective Studies. Sex Distribution. Syndrome

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  • [CommentIn] Dermatology. 2007;215(4):360; author reply 360-1 [17911998.001]
  • (PMID = 17191046.001).
  • [ISSN] 1018-8665
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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33. Kavak A, Parlak AH, Yesildal N, Aydogan I, Anul H: Preliminary study among truck drivers in Turkey: effects of ultraviolet light on some skin entities. J Dermatol; 2008 Mar;35(3):146-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Preliminary study among truck drivers in Turkey: effects of ultraviolet light on some skin entities.
  • In this study, we aimed to compare driver (left) and opposite (right) sides for some skin entities in drivers.
  • We also evaluated the effect of occupational duration, age and skin type among this population.
  • Dermatological entities such as actinic keratosis, solar lentigo, seborrheic keratosis, melanocytic nevus, spider angioma, ephelid, basal cell carcinoma (BCC), squamous cell carcinoma, and melanoma were compared to driver and right sides.
  • (ii) occupational duration (subgroups O1, 1-10 years, and 02, >10 years); and (iii) skin type (subgroups S1, skin types I and II, and S2, skin types III and IV.
  • [MeSH-major] Commerce. Motor Vehicles. Occupational Diseases / pathology. Occupational Exposure / adverse effects. Skin Diseases / pathology. Ultraviolet Rays / adverse effects

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  • (PMID = 18346257.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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34. Haass NK, Wladykowski E, Kief S, Moll I, Brandner JM: Differential induction of connexins 26 and 30 in skin tumors and their adjacent epidermis. J Histochem Cytochem; 2006 Feb;54(2):171-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Differential induction of connexins 26 and 30 in skin tumors and their adjacent epidermis.
  • Gap junctions (GJs) have been shown to play a role in tumor progression including a variety of keratinocyte-derived and non-keratinocyte-derived skin tumors.
  • Here we show that the synthesis of the GJ proteins connexin 26 and connexin 30 (Cx26 and Cx30) is induced in keratinocyte-derived epithelial skin tumors whereas there is either no change or a downregulation of Cx43.
  • Cx26, Cx30, and Cx43 are absent in non-epithelial skin tumors.
  • Further, Cx26 and Cx30 are induced in the epidermis adjacent to malignant melanoma but absent in the epidermis adjacent to benign non-epithelial skin lesions (melanocytic nevi and angioma).
  • The keratinocyte-derived skin tumors are very heterogeneous regarding the Cx26/Cx30 pattern in the epidermis at the periphery of the tumors.
  • We further discuss the putative roles of these gap junctional proteins in tumor progression.
  • [MeSH-major] Connexins / biosynthesis. Epidermis / metabolism. Skin Neoplasms / metabolism
  • [MeSH-minor] Animals. Bowen's Disease / metabolism. Carcinoma, Basal Cell / metabolism. Carcinoma, Squamous Cell / metabolism. Hemangioma / metabolism. Humans. Keratinocytes / metabolism. Keratins / metabolism. Keratosis / metabolism. Liver / metabolism. Melanoma / metabolism. Mice. Mice, Inbred C57BL. Microscopy, Fluorescence. Nevus, Pigmented / metabolism. Warts / metabolism

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  • (PMID = 16046668.001).
  • [ISSN] 0022-1554
  • [Journal-full-title] The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
  • [ISO-abbreviation] J. Histochem. Cytochem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Connexins; 0 / GJB6 protein, human; 127120-53-0 / connexin 26; 68238-35-7 / Keratins
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35. Bienaimé A, Rojat-Habib MC, Hesse S, Pelissier JF, Bonerandi JJ: [Giant vascular tumour in an adult: tufted angioma or kaposiform hemangioendothelioma]. Ann Dermatol Venereol; 2006 Jun-Jul;133(6-7):553-6
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  • [Title] [Giant vascular tumour in an adult: tufted angioma or kaposiform hemangioendothelioma].
  • [Transliterated title] Tumeur vasculaire géante de l'adulte: angiome en touffe ou hémangioendothéliome kaposiforme.
  • INTRODUCTION: Tufted angioma and kaposiform hemangioendothelioma are two rare benign but aggressive vascular tumours that occur mainly in children.
  • OBSERVATION: A 72 year-old man consulted for a 50 cm wide vascular tumour of the right shoulder which was increasing for 10 years.
  • On histological examination there were features of tufted angioma and kaposiform hemangioendothelioma.
  • The histological association of aspects which could correspond to tufted angioma and kaposiform hemangioendothelioma seems to confirm recent publications which support the hypothesis that these two tumours are two evolutive stages of one and only entity.
  • [MeSH-major] Hemangioendothelioma / pathology. Hemangioma / pathology. Skin Neoplasms / pathology


36. Dégardin-Capon N, Martinot-Duquennoy V, Patenotre P, Brevière GM, Piette F, Pellerin P: [Early surgical treatment of cutaneous hemangiomas]. Ann Chir Plast Esthet; 2006 Aug-Oct;51(4-5):321-9
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  • [Title] [Early surgical treatment of cutaneous hemangiomas].
  • Infantile hemangioma appears after the birth as a vascular tumor, which is known for its characteristic evolution in 3 phases: rapid augmentation then stabilization and involution on several years with in the best cases, classical "restitutio ad integrum".
  • Surgery consists in these cases in a simple volumetric diminution of the tumor with no aim for esthetic improvement.
  • Other kinds of hemangiomas require an early surgical treatment before their complete involution.
  • In some cases, hemangiomas present a delayed involution with minor regression capacity; these are mainly located on the median part of the face and have principally a subcutaneous development.
  • [MeSH-major] Hemangioma / surgery. Skin Neoplasms / surgery
  • [MeSH-minor] Age Factors. Child. Child, Preschool. Facial Neoplasms / pathology. Facial Neoplasms / physiopathology. Facial Neoplasms / surgery. Hemangioma, Capillary / pathology. Hemangioma, Capillary / physiopathology. Hemangioma, Capillary / surgery. Humans. Infant. Maxillofacial Development / physiology. Remission, Spontaneous

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  • (PMID = 16997445.001).
  • [ISSN] 0294-1260
  • [Journal-full-title] Annales de chirurgie plastique et esthétique
  • [ISO-abbreviation] Ann Chir Plast Esthet
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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37. Lee B, Chiu M, Soriano T, Craft N: Adult-onset tufted angioma: a case report and review of the literature. Cutis; 2006 Nov;78(5):341-5
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  • [Title] Adult-onset tufted angioma: a case report and review of the literature.
  • Tufted angiomas (TAs) are benign vascular tumors, primarily occurring on the trunk and extremities of children younger than 5 years.
  • [MeSH-major] Hemangioma / pathology. Lip Neoplasms / pathology. Skin Neoplasms / pathology


38. Pascual-Castroviejo I, Pascual-Pascual SI, Velazquez-Fragua R, García-Guereta L, López-Gutiérrez JC, Olivares P, Tovar J: Association of cutaneous red-to-purple hemangiomas with leptomeningeal hemangiomas. a clinical study of two patients. Neuropediatrics; 2010 Feb;41(1):7-11
Hazardous Substances Data Bank. GADOLINIUM, ELEMENTAL .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Association of cutaneous red-to-purple hemangiomas with leptomeningeal hemangiomas. a clinical study of two patients.
  • Cutaneous hemangioma is a benign vascular tumor of infancy with an initial proliferating period that appears between 1 to 2 weeks of life, extends during 18 months to 2 years of life, and then slowly regresses during several years until it disappears completely.
  • Vascular malformations are present at birth, grow commensurately with the child, and are characterized histologically by a normal rate of endothelial cell turnover, flat endothelium, thin (normal) basal membrane and normal mast cells.
  • These cutaneous anomalies are commonly associated with cerebellar malformations, main cerebral arteries anomalies, congenital cardiac anomalies and/or coarctation of the aorta and persistence of embryonic arteries.
  • Cutaneous hemangiomas can be associated with intracranial or extracranial hemangiomas that regress at the same time as the cutaneous hemangiomas.
  • Cutaneous hemangiomas may show different types of color.
  • Cutaneous red-to-purple hemangiomas are uncommon and their bright-red color is evident from the first weeks of life and remains unaltered until the hemangioma disappears.
  • The intracranial angiographic studies in our series of more than 50 cases with facial hemangioma showed that patients with red-to-purple hemangiomas are commonly associated with localized leptomeningeal hemangiomas either in the ipsilateral or contralateral side.
  • These leptomingeal hemangiomas were visualized only by MR enhanced with gadolinium.
  • Involution of the cutaneous and leptomeningeal hemangiomas seems to occur simultaneously as in other types of external and internal hemangiomas.
  • [MeSH-major] Hemangioma. Meningeal Neoplasms. Skin Diseases, Vascular. Skin Neoplasms

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  • (PMID = 20571984.001).
  • [ISSN] 1439-1899
  • [Journal-full-title] Neuropediatrics
  • [ISO-abbreviation] Neuropediatrics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] AU0V1LM3JT / Gadolinium
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39. Mauroo NF, Rourke NL, Chan WK: Cutaneous hemangioma in a giant panda (Ailuropoda melanoleuca). J Zoo Wildl Med; 2006 Mar;37(1):59-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cutaneous hemangioma in a giant panda (Ailuropoda melanoleuca).
  • An adult male giant panda (Ailuropoda melanoleuca) was presented with a cutaneous mass ventral to the eye.
  • Histopathologic examination determined that the mass was a benign cavernous hemangioma, the first reported case in a giant panda.
  • [MeSH-major] Hemangioma, Cavernous / veterinary. Skin Neoplasms / veterinary. Ursidae

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  • (PMID = 17312815.001).
  • [ISSN] 1042-7260
  • [Journal-full-title] Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians
  • [ISO-abbreviation] J. Zoo Wildl. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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40. de Mesquita CJ: About strawberry, crab claws, and the Sir James Black's invention. Hypothesis: can we battle keloids with propranolol? Med Hypotheses; 2010 Feb;74(2):353-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The cutaneous hemangiomas of infancy or infantile hemangiomas are the most common benign tumor of childhood.
  • They were formerly known as strawberry hemangiomas in reason of its typical appearance although uncommon morphologic variations can be found.
  • Usually hemangiomas are harmless growths that are the result of proliferation of endothelial cells during early childhood.
  • Occasionally, infantile hemangiomas suffer dramatic overgrowth causing esthetical damages, as well compromises to vital structures that requires prompt intervention.
  • Propranolol, a beta-adrenergic receptor antagonist that was invented by Sir James Black in 1960s, appears to be an effective treatment for infantile hemangiomas and should now be used as a first-line treatment in hemangiomas when intervention is required.

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  • (PMID = 19758768.001).
  • [ISSN] 1532-2777
  • [Journal-full-title] Medical hypotheses
  • [ISO-abbreviation] Med. Hypotheses
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Vasodilator Agents; 9Y8NXQ24VQ / Propranolol
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41. Nord KM, Kandel J, Lefkowitch JH, Lobritto SJ, Morel KD, North PE, Garzon MC: Multiple cutaneous infantile hemangiomas associated with hepatic angiosarcoma: case report and review of the literature. Pediatrics; 2006 Sep;118(3):e907-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multiple cutaneous infantile hemangiomas associated with hepatic angiosarcoma: case report and review of the literature.
  • Multiple cutaneous hemangiomas can be associated with internal hemangiomas, with the liver being the most common site.
  • Here we report a case of a premature female neonate who presented with cardiac failure at birth and had typical-appearing infantile hemangiomas on the skin in association with vascular lesions in the liver.
  • Her clinical presentation was felt to be consistent with cutaneous and hepatic infantile hemangiomas.
  • Histopathologic evaluation of the liver revealed a diagnosis of type 2 infantile hepatic hemangioendothelioma (regarded as synonymous with angiosarcoma) rather than benign infantile hemangioma of the liver.
  • Subsequent skin biopsies confirmed that her multiple cutaneous lesions were infantile hemangiomas and not metastatic angiosarcoma.
  • We report this case and a review of the literature on pediatric angiosarcoma of the liver associated with cutaneous infantile hemangiomas.
  • [MeSH-major] Hemangioma / pathology. Hemangiosarcoma / pathology. Liver Neoplasms / pathology. Skin Neoplasms / pathology

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  • [ErratumIn] Pediatrics. 2007 Jun;119(6):1271
  • (PMID = 16880251.001).
  • [ISSN] 1098-4275
  • [Journal-full-title] Pediatrics
  • [ISO-abbreviation] Pediatrics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 27
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42. Ishikawa K, Hatano Y, Ichikawa H, Hashimoto H, Fujiwara S: The spontaneous regression of tufted angioma. A case of regression after two recurrences and a review of 27 cases reported in the literature. Dermatology; 2005;210(4):346-8
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The spontaneous regression of tufted angioma. A case of regression after two recurrences and a review of 27 cases reported in the literature.
  • BACKGROUND: Tufted angioma, a peculiar angioma that is characterized by tufts of capillary-sized vessels scattered 'cannonball fashion' within the dermis, is known, on occasion, to regress spontaneously.
  • OBJECTIVE: To know the appropriate waiting period for spontaneous regression of tufted angioma.
  • METHODS: We report here a case of tufted angioma that regressed spontaneously after the lesions had recurred twice.
  • We also review previously reported cases of tufted angioma with spontaneous regression, including cases in the Japanese and non-Japanese literature.
  • [MeSH-major] Hemangioma, Capillary / pathology. Neoplasm Regression, Spontaneous / pathology. Skin Neoplasms / pathology

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  • [Copyright] 2005 S. Karger AG, Basel
  • (PMID = 15942226.001).
  • [ISSN] 1018-8665
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 10
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43. Caroli E, Salvati M, Roperto R, D'Andrea G, Ferrante L: High-dose radiation-induced meningioma in children - case report and critical review of the literature. Zentralbl Neurochir; 2005 Feb;66(1):39-42
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  • We discuss the clinical data and the differences of these rare tumors from those of spontaneous counterpart and radiation-induced meningiomas of the adult population.
  • CASE REPORT: We report a case of meningothelial meningioma, which occurred in a 9-year-old boy who underwent radiotherapy for a parieto-occipital cutaneous angioma.
  • CONCLUSION: Exposure to the potentially carcinogenic effects of radiotherapy should be reserved only for tumors that demonstrate subsequent progression.
  • [MeSH-minor] Child. Female. Hemangioma / complications. Hemangioma / radiotherapy. Humans. Male. Neurosurgical Procedures. Sex Characteristics. Skin Neoplasms / complications. Skin Neoplasms / radiotherapy

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  • (PMID = 15744628.001).
  • [ISSN] 0044-4251
  • [Journal-full-title] Zentralblatt für Neurochirurgie
  • [ISO-abbreviation] Zentralbl. Neurochir.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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44. Piccirilli M, di Norcia V, Frati A, Salvati M: Glioblastoma in irradiated elderly patients: two case reports. Neurosurg Rev; 2005 Jul;28(3):226-8
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  • We report our experience with two elderly patients with histologically proven diagnosis of glioblastoma multiforme who were treated 25 and 18 years earlier for tinea capitis and scalp cutaneous hemangioma respectively in the same areas where the glioblastoma multiforme had grown.
  • [MeSH-minor] Dermatologic Surgical Procedures. Female. Humans. Infant. Infant, Newborn. Intracranial Pressure. Male. Skin / pathology. Skin Transplantation. Surgical Flaps

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  • (PMID = 15614578.001).
  • [ISSN] 0344-5607
  • [Journal-full-title] Neurosurgical review
  • [ISO-abbreviation] Neurosurg Rev
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 35
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45. Maurer GD, Schittenhelm J, Ernemann U, Kempf VA, Ritz R, Weller M, Schmidt F: Intracranial hemangiomas in a patient with POEMS syndrome. J Neurol; 2010 Mar;257(3):484-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intracranial hemangiomas in a patient with POEMS syndrome.
  • POEMS syndrome is a rare multi-system disease with typical features of polyneuropathy, organomegaly, endocrinopathy, monoclonal plasmaproliferative disorder and skin changes.
  • We describe a 44-year-old woman with polyneuropathy, hepatomegaly, IgA lambda-plasmacytoma, thrombocytosis, papilledema with elevated protein levels in cerebrospinal fluid and multiple cutaneous hemangiomas who was diagnosed with three intracranial lesions.
  • Histology revealed capillary hemangiomas, one of them displaying partially glomeruloid features.
  • [MeSH-major] Brain / pathology. Brain Neoplasms / etiology. Brain Neoplasms / pathology. Hemangioma, Cavernous, Central Nervous System / etiology. Hemangioma, Cavernous, Central Nervous System / pathology. POEMS Syndrome / complications
  • [MeSH-minor] Biomarkers / blood. Diplopia / immunology. Diplopia / physiopathology. Female. Humans. Immunoglobulin A / blood. Magnetic Resonance Imaging. Middle Aged. Neurosurgical Procedures. Peripheral Nervous System Diseases / immunology. Peripheral Nervous System Diseases / physiopathology. Plasmacytoma / complications. Plasmacytoma / immunology. Radiography. Treatment Outcome. Up-Regulation / physiology. Vascular Endothelial Growth Factor A / blood. Vision, Low / immunology. Vision, Low / physiopathology

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  • (PMID = 19943169.001).
  • [ISSN] 1432-1459
  • [Journal-full-title] Journal of neurology
  • [ISO-abbreviation] J. Neurol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Immunoglobulin A; 0 / Vascular Endothelial Growth Factor A
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46. Li L, Qin P: [Prenatal diagnosis and outcomes of fetuses with cutaneous hemangioma]. Zhonghua Fu Chan Ke Za Zhi; 2006 Sep;41(9):605-7
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  • [Title] [Prenatal diagnosis and outcomes of fetuses with cutaneous hemangioma].
  • OBJECTIVE: To study the ultrasonic characteristics of fetal cutaneous hemangioma and the association with perinatal outcomes.
  • METHODS: Five fetuses with cutaneous hemangioma were detected by gray-scale and color Doppler ultrasound, compared with the result of pathology and hematology examinations after birth.
  • The other two fetuses who had small tumors diagnosed by ultrasound did not develop any perinatal complications, and the neonates had favourable prognosis.
  • CONCLUSIONS: Massive hemangiomas are frequently associated with life-threatening complications such as high-output heart failure, thrombocytopenia and disseminated intravascular coagulopathy (Kasabach-Merritt syndrome).
  • [MeSH-major] Fetal Diseases / ultrasonography. Hemangioma / ultrasonography. Skin Neoplasms / ultrasonography. Ultrasonography, Prenatal / methods

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  • (PMID = 17181970.001).
  • [ISSN] 0529-567X
  • [Journal-full-title] Zhonghua fu chan ke za zhi
  • [ISO-abbreviation] Zhonghua Fu Chan Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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47. Maramattom BV, Cohen-Gadol AA, Wijdicks EF, Kallmes D: Segmental cutaneous hemangioma and spinal arteriovenous malformation (Cobb syndrome). Case report and historical perspective. J Neurosurg Spine; 2005 Sep;3(3):249-52
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  • [Title] Segmental cutaneous hemangioma and spinal arteriovenous malformation (Cobb syndrome). Case report and historical perspective.
  • The discovery of either a dermatomal cutaneous nevus or a spinal arteriovenous malformation (AVM) should raise the suspicion of Cobb syndrome.
  • The Cobb syndrome is a neurocutaneous syndrome in which there are metameric cutaneous and spinal AVMs.
  • The authors present the case of a patient with acute cervical myelopathy and subtle cutaneous hemangiomas in whom a cervical perimedullary fistula was discovered.
  • [MeSH-major] Arteriovenous Malformations / pathology. Arteriovenous Malformations / therapy. Hemangioma / pathology

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  • (PMID = 16235712.001).
  • [ISSN] 1547-5654
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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48. Al-Kaabi A, Yanofsky R, Bunge M, Hyman J, Rafay MF: Diffuse hemangiomatosis with predominant central nervous system involvement. Pediatr Neurol; 2009 Jan;40(1):54-7
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  • Diffuse neonatal hemangiomatosis presents with multiple, progressive, rapidly growing cutaneous hemangiomas associated with widespread visceral hemangiomas in the liver, lungs, gastrointestinal tract, brain, and meninges.
  • The early appearance of central nervous system lesions on imaging can overlap with that of cavernous malformations, confounding diagnosis; however, rapid growth, response to steroids, cystic appearance with sedimentation levels of the mature lesions, and involvement of other visceral organs can help confirm the diagnosis.
  • [MeSH-major] Central Nervous System Venous Angioma / diagnosis. Hemangioma, Cavernous, Central Nervous System / diagnosis. Neoplasms, Multiple Primary / diagnosis
  • [MeSH-minor] Dexamethasone / therapeutic use. Diagnosis, Differential. Disease Progression. Female. Glucocorticoids / therapeutic use. Humans. Infant. Magnetic Resonance Imaging. Skin Neoplasms / diagnosis. Treatment Outcome

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  • (PMID = 19068256.001).
  • [ISSN] 0887-8994
  • [Journal-full-title] Pediatric neurology
  • [ISO-abbreviation] Pediatr. Neurol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Glucocorticoids; 7S5I7G3JQL / Dexamethasone
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49. Noyes N, Porcu E, Borini A: Over 900 oocyte cryopreservation babies born with no apparent increase in congenital anomalies. Reprod Biomed Online; 2009 Jun;18(6):769-76
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  • Of the total 936 live borns, 1.3% (12) were noted to have birth anomalies: three ventricular septal defects, one choanal and one biliary atresia, one Rubinstein-Taybi syndrome, one Arnold-Chiari syndrome, one cleft palate, three clubfoot and one skin haemangioma.

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  • (PMID = 19490780.001).
  • [ISSN] 1472-6491
  • [Journal-full-title] Reproductive biomedicine online
  • [ISO-abbreviation] Reprod. Biomed. Online
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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50. Wallen KE, Hadar EJ, Perry V, Bouldin TW, Loehr J, Blatt J: Posterior fossa neoplasm and PHACES syndrome: a case report. J Pediatr Hematol Oncol; 2009 Mar;31(3):203-5
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  • A 4-year-old girl with PHACES syndrome (posterior fossa brain malformations, hemangiomas, arterial anomalies, cardiac anomalies/coarctation of the aorta, eye abnormalities, and sternal clefting/supraumbilical raphe) developed a cerebellar pilocytic astrocytoma 18 months after resolution of her neck, ear, and thoracic hemangiomas.
  • Because cutaneous hemangiomas may have involuted by the time a patient is diagnosed with a central nervous system neoplasm, it seems possible that in other such patients the association may have gone unrecognized.
  • [MeSH-major] Abnormalities, Multiple. Astrocytoma / etiology. Brain / abnormalities. Hemangioma / complications. Infratentorial Neoplasms / etiology

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  • (PMID = 19262249.001).
  • [ISSN] 1536-3678
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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51. Denaro L, Pallini R, Di Muro L, Ciampini A, Vellone V, Lauretti L, Fernandez E, Maira G: Primary hemorrhagic intramedullary melanoma. Case report with emphasis on the difficult preoperative diagnosis. J Neurosurg Sci; 2007 Dec;51(4):181-3
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  • [Title] Primary hemorrhagic intramedullary melanoma. Case report with emphasis on the difficult preoperative diagnosis.
  • Preoperative diagnosis of melanocytic lesion as a PSM is difficult, because of the heterogeneous magnetic resonance (MR) signal intensity, due to hemorrhagic foci and melanin deposits.
  • We describe the case of a 68 year-old male with a MR showing at Th8-Th9 level a well-defined intramedullary lesion; for the characteristics of hemorrhagic signal on MR and its association with a presumptive brain cavernoma, a preoperative diagnosis of intramedullary cavernous angioma was suspected.
  • Pathological examination revealed a melanoma, and for the absence of other localizations outside the spinal cord, a diagnosis of primary spinal melanoma was established.
  • The growth of PSM is slower and survival is longer than in the most common spinal metastasis from skin melanoma.
  • We report this case to underline the importance and difficulties concerning the preoperative diagnosis of a hemorrhagic intramedullary lesion.
  • [MeSH-minor] Aged. Brain Neoplasms / pathology. Diagnosis, Differential. Disease Progression. Frontal Lobe / pathology. Hemangioma, Cavernous, Central Nervous System / pathology. Hemorrhage / etiology. Hemorrhage / pathology. Hemorrhage / surgery. Humans. Magnetic Resonance Imaging. Male. Neurosurgical Procedures. Paraparesis / etiology. Paraparesis / pathology. Paraparesis / physiopathology. Preoperative Care. Thoracic Vertebrae. Treatment Outcome

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  • (PMID = 17987003.001).
  • [ISSN] 0390-5616
  • [Journal-full-title] Journal of neurosurgical sciences
  • [ISO-abbreviation] J Neurosurg Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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52. Selim H, Selim A, Khachemoune A, Metwally SA: Use of sclerosing agent in the management of oral and perioral hemangiomas: review and case reports. Med Sci Monit; 2007 Sep;13(9):CS114-119
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  • [Title] Use of sclerosing agent in the management of oral and perioral hemangiomas: review and case reports.
  • BACKGROUND: Most cutaneous hemangiomas involute spontaneously.
  • CASE REPORTS: Three hemangioma cases were treated by repeated local injection of 5% ethanolamine oleate solution.
  • CONCLUSIONS: Use of 5% ethanolamine oleate as a sclerosing agent for repeated intralesional injection in the management of facial hemangiomas is a safe treatment with acceptable results.
  • [MeSH-major] Hemangioma / drug therapy. Hemangioma / pathology. Mouth Neoplasms / drug therapy. Mouth Neoplasms / pathology. Sclerosing Solutions / therapeutic use. Sclerotherapy
  • [MeSH-minor] Adolescent. Biomarkers, Tumor / metabolism. Female. Humans. Immunohistochemistry. Infant. Tomography Scanners, X-Ray Computed

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  • (PMID = 17767124.001).
  • [ISSN] 1234-1010
  • [Journal-full-title] Medical science monitor : international medical journal of experimental and clinical research
  • [ISO-abbreviation] Med. Sci. Monit.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Sclerosing Solutions
  • [Number-of-references] 32
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53. Faik A, Allali F, El Hassani S, Hajjaj-Hassouni N: Maffucci's syndrome: a case report. Clin Rheumatol; 2006 Feb;25(1):88-91

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  • Physical examination showed a marked shortening of both upper and lower limbs and cutaneous hemangioma in the legs.
  • Histological examination of the skin specimen showed a hemangioendothelioma.
  • The diagnosis of Maffucci's syndrome was established.
  • [MeSH-minor] Adult. Female. Hemangioendothelioma / pathology. Humans. Radiography. Skin Neoplasms / pathology

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  • (PMID = 16234991.001).
  • [ISSN] 0770-3198
  • [Journal-full-title] Clinical rheumatology
  • [ISO-abbreviation] Clin. Rheumatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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54. Kreusel KM: Ophthalmological manifestations in VHL and NF 1: pathological and diagnostic implications. Fam Cancer; 2005;4(1):43-7
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  • Capillary retinal angioma, a benign vascular tumor, is the classical ocular lesion in VHL.
  • It often appears as the first manifestation of the disease and may thus lead to the diagnosis of VHL.
  • Extension of the tumor beyond the chiasm worsens the prognosis quoad vitam.
  • The hallmark of NF 1, namely cutaneous neurofibroma can cause visual impairment when affecting the skin of the eyelids.
  • [MeSH-major] Hemangioma / etiology. Neurofibromatosis 1 / complications. Neurofibromatosis 1 / diagnosis. Optic Nerve Glioma / etiology. Retinal Neoplasms / etiology. von Hippel-Lindau Disease / complications. von Hippel-Lindau Disease / diagnosis

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  • (PMID = 15883709.001).
  • [ISSN] 1389-9600
  • [Journal-full-title] Familial cancer
  • [ISO-abbreviation] Fam. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 63
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55. Di Iorio G, Sanges G, Sannino V, De Cristofaro M, D'Ambrosio MR, Budillon A, Sampaolo S: Peripheral nervous system involvement in Klippel-Trenaunay syndrome. Clin Neuropathol; 2005 Jan-Feb;24(1):42-7
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  • Klippel-Trenaunay syndrome (KTS) is a rare congenital malformation of unknown etiology characterized by cutaneous hemangiomas, venous varicosities and bony and soft tissues hypertrophy usually affecting one limb.
  • We describe the case of a 67-year-old woman with KTS and peripheral neuropathy related to the presence of epineurial microscopic arteriovenous anastomoses (AVA) and endoneurial vascular coils in sural nerve biopsy from both hypertrophic and non-hypertrophic limb.

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  • (PMID = 15696784.001).
  • [ISSN] 0722-5091
  • [Journal-full-title] Clinical neuropathology
  • [ISO-abbreviation] Clin. Neuropathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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56. Garzon MC, Lucky AW, Hawrot A, Frieden IJ: Ultrapotent topical corticosteroid treatment of hemangiomas of infancy. J Am Acad Dermatol; 2005 Feb;52(2):281-6
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  • [Title] Ultrapotent topical corticosteroid treatment of hemangiomas of infancy.
  • BACKGROUND: Superficial cutaneous hemangiomas of infancy represent a therapeutic challenge.
  • Two small case series using ultrapotent topical corticosteroids for periocular hemangiomas were reported in the ophthalmologic literature.
  • The use of this therapy for hemangiomas of infancy at other sites on the body has not been reported.
  • OBJECTIVE: We sought to assess the clinical effects of short-term application of ultrapotent topical corticosteroids for the treatment of hemangiomas of infancy.
  • METHODS: The records of 34 infants with proliferating hemangiomas of infancy that were treated with ultrapotent topical steroids were reviewed retrospectively.
  • CONCLUSIONS: Hemangiomas in 74% of the infants demonstrated either good or partial response to treatment with ultrapotent topical corticosteroids.
  • Improvement varied, with thinner superficial hemangiomas demonstrating better cosmetic improvement than thicker lesions.
  • [MeSH-major] Betamethasone / analogs & derivatives. Clobetasol / analogs & derivatives. Hemangioma / drug therapy. Skin Neoplasms / drug therapy
  • [MeSH-minor] Administration, Cutaneous. Extremities. Eye Neoplasms / drug therapy. Eyelids. Facial Neoplasms / drug therapy. Female. Humans. Infant. Infant, Newborn. Male. Retrospective Studies. Treatment Outcome

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  • (PMID = 15692474.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 826Y60901U / betamethasone-17,21-dipropionate; 9842X06Q6M / Betamethasone; 9P6159HM7T / halobetasol; ADN79D536H / Clobetasol
  • [Number-of-references] 14
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57. Gleizal A, Torossian JM, Geha H, Lebreton F, Beziat JL: [Testicular choriocarcinoma presenting as cutaneous metastasis. A case report and review of the literature]. Ann Chir Plast Esthet; 2005 Jun;50(3):237-41
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  • [Title] [Testicular choriocarcinoma presenting as cutaneous metastasis. A case report and review of the literature].
  • [Transliterated title] Les métastases cutanées révélatrices des choriocarcinomes: revue de la littérature. A propos d'une localisation nasale d'origine testiculaire.
  • Choriocarcinoma are germinal tumors from testicular cells in men or foetal trophoblast in women.
  • Cutaneous metastasis are very rare.
  • The authors report a case of angioma-like tumor in a 22-year-old man which was a cutaneous metastasis of a testicular carcinoma.
  • Diagnosis was of course histologic.
  • Testicular echography showed an intra testicular tumor, pulmonary and abdominal CT-scan showed multiple metastases.
  • Patient died 14 months after diagnosis.
  • Only 11 cases of cutaneous metastasis of choriocarcinoma were found in the world literature (7 men and 4 women).
  • All cases showed diagnosis trap for plastic surgeon.
  • [MeSH-major] Choriocarcinoma / secondary. Nose Neoplasms / secondary. Skin Neoplasms / secondary. Testicular Neoplasms / pathology

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  • (PMID = 15963845.001).
  • [ISSN] 0294-1260
  • [Journal-full-title] Annales de chirurgie plastique et esthétique
  • [ISO-abbreviation] Ann Chir Plast Esthet
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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58. Rajaonarivony T, Randriamananjara N, Rakotoarisoa AJ, Rantomalala HY, Ranaivozanany A: [A case of Klippel-Trenaunay-Weber syndrome of the hand: description and review of the literature]. Ann Cardiol Angeiol (Paris); 2005 Sep;54(5):289-91
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  • [Transliterated title] Un cas de syndrome de Klippel-Trenaunay-Weber de la main: description et revue de la littérature.
  • The patient presented with cutaneous hemangioma, varicosities and unilateral hypertrophy of soft tissues of the left hand.
  • [MeSH-major] Klippel-Trenaunay-Weber Syndrome / diagnosis
  • [MeSH-minor] Arteriovenous Fistula / diagnosis. Arteriovenous Fistula / surgery. Arteriovenous Shunt, Surgical. Child. Female. Hand / pathology. Hemangioma / etiology. Hemangioma / surgery. Humans. Hypertrophy / etiology. Hypertrophy / surgery. Skin Neoplasms / etiology. Skin Neoplasms / surgery

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  • (PMID = 16237920.001).
  • [ISSN] 0003-3928
  • [Journal-full-title] Annales de cardiologie et d'angéiologie
  • [ISO-abbreviation] Ann Cardiol Angeiol (Paris)
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 11
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59. Pascual-Castroviejo I, Lopez-Gutierrez JC: Cutaneous hemangioma associated with persistence of the trigeminal and both proatlantal arteries. J Child Neurol; 2007 Mar;22(3):337-40
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  • [Title] Cutaneous hemangioma associated with persistence of the trigeminal and both proatlantal arteries.
  • The authors describe a girl who was evaluated at 7 years old because of facial segmental hemangioma associated with unilateral persistent trigeminal artery, bilateral proatlantal arteries, hypoplasia of 1 posterior cerebral artery, kinking of 1 internal carotid artery at 2 different levels, and transdural collateral vascularization supplying the posterior areas of the cerebral hemispheres.
  • This is the first patient known to have a cutaneous hemangioma associated with bilateral proatlantal arteries despite having a unilateral facial hemangioma.
  • [MeSH-major] Hemangioma / complications. Skin Diseases, Vascular / complications. Skin Neoplasms / complications

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  • (PMID = 17621508.001).
  • [ISSN] 0883-0738
  • [Journal-full-title] Journal of child neurology
  • [ISO-abbreviation] J. Child Neurol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
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60. Sevinir B, Ozkan TB: Infantile hepatic hemangioendothelioma: clinical presentation and treatment. Turk J Gastroenterol; 2007 Sep;18(3):182-7
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  • BACKGROUND/AIMS: Hepatic hemangioendotheliomas are rare tumors in childhood.
  • RESULTS: The median age at diagnosis was 24 days (age range: 1 to 70 days) and the female/male ratio was 5/3.
  • Cutaneous hemangiomas were present in four cases.
  • Four cases had single hepatic tumors while the others had multiple.
  • The tumor size ranged from 2 cm to 10 cm in diameter.
  • Most of the multifocal hepatic tumors were associated with skin hemangiomas.
  • [MeSH-major] Hemangioendothelioma / diagnosis. Hemangioendothelioma / therapy. Liver Neoplasms / diagnosis. Liver Neoplasms / therapy
  • [MeSH-minor] Abdomen. Alanine Transaminase / metabolism. Aspartate Aminotransferases / metabolism. Dilatation, Pathologic / etiology. Female. Glucocorticoids / therapeutic use. Hemangioma / diagnosis. Hepatomegaly / etiology. Humans. Immunologic Factors / therapeutic use. Infant. Infant, Newborn. Interferon-alpha / therapeutic use. Male. Neoplasms, Multiple Primary. Prednisolone / therapeutic use. Respiratory Distress Syndrome, Newborn / etiology. Retrospective Studies. Skin Neoplasms / diagnosis. Turkey / epidemiology

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  • (PMID = 17891692.001).
  • [ISSN] 2148-5607
  • [Journal-full-title] The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
  • [ISO-abbreviation] Turk J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Turkey
  • [Chemical-registry-number] 0 / Glucocorticoids; 0 / Immunologic Factors; 0 / Interferon-alpha; 9PHQ9Y1OLM / Prednisolone; EC 2.6.1.1 / Aspartate Aminotransferases; EC 2.6.1.2 / Alanine Transaminase
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61. Zambanini S, Sablatnig R, Maier H, Langs G: Automatic image-based assessment of lesion development during hemangioma follow-up examinations. Artif Intell Med; 2010 Oct;50(2):83-94
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  • [Title] Automatic image-based assessment of lesion development during hemangioma follow-up examinations.
  • OBJECTIVE: This paper presents an automatic method for the quantification of the development of cutaneous hemangiomas in digital images.
  • (1) the skin area affected by the lesion is measured and (2) the change of the hemangioma during follow-up examinations called regression is determined.
  • METHODS AND MATERIAL: The proposed method classifies individual pixels and calculates the area based on a ruler attached to the skin.
  • CONCLUSIONS: The results indicate that the proposed method provides an accurate and objective evaluation of the course of cutaneous hemangiomas.
  • [MeSH-major] Hemangioma / diagnosis. Skin Neoplasms / diagnosis

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  • [Copyright] Copyright © 2010 Elsevier B.V. All rights reserved.
  • (PMID = 20729044.001).
  • [ISSN] 1873-2860
  • [Journal-full-title] Artificial intelligence in medicine
  • [ISO-abbreviation] Artif Intell Med
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
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62. Yang JH, Kim JW, Park HS, Jang SJ, Choi JC: Eruptive pseudoangiomatosis. J Dermatol; 2006 Dec;33(12):873-6

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  • It is characterized by an eruption of distinctive erythematous angioma-like papules often surrounded by a pale halo, with histological findings distinct from that of true angiomas.
  • We describe three women with angioma-like papules.
  • [MeSH-major] Angiomatosis / diagnosis. Skin Diseases, Vascular / diagnosis
  • [MeSH-minor] Aged. Biopsy. Capillaries / pathology. Diagnosis, Differential. Endothelial Cells / pathology. Endothelium, Vascular / pathology. Exanthema / diagnosis. Female. Hemangioma / diagnosis. Humans. Lymphocytes / pathology. Middle Aged. Skin Neoplasms / diagnosis

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  • (PMID = 17169093.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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63. Iacobas I, Burrows PE, Frieden IJ, Liang MG, Mulliken JB, Mancini AJ, Kramer D, Paller AS, Silverman R, Wagner AM, Metry DW: LUMBAR: association between cutaneous infantile hemangiomas of the lower body and regional congenital anomalies. J Pediatr; 2010 Nov;157(5):795-801.e1-7
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  • [Title] LUMBAR: association between cutaneous infantile hemangiomas of the lower body and regional congenital anomalies.
  • OBJECTIVE: To define the clinical spectrum of regional congenital anomalies associated with large cutaneous hemangiomas of the lower half of the body, clarify risk for underlying anomalies on the basis of hemangioma location, and provide imaging guidelines for evaluation.
  • RESULTS: Hemangiomas in our series tended to be "segmental" and often "minimal growth" in morphology.
  • Extensive limb hemangiomas also showed potential for extracutaneous anomalies, including underlying arterial anomalies, limb underdevelopment, and ulceration.
  • The cutaneous hemangioma and underlying anomalies demonstrated regional correlation.
  • CONCLUSIONS: We propose the acronym "LUMBAR" to describe the association of Lower body hemangioma and other cutaneous defects, Urogenital anomalies, Ulceration, Myelopathy, Bony deformities, Anorectal malformations, Arterial anomalies, and Renal anomalies.
  • [MeSH-major] Congenital Abnormalities. Hemangioma / complications. Skin Neoplasms / complications

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  • [Copyright] Copyright © 2010 Mosby, Inc. All rights reserved.
  • (PMID = 20598318.001).
  • [ISSN] 1097-6833
  • [Journal-full-title] The Journal of pediatrics
  • [ISO-abbreviation] J. Pediatr.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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64. Osio A, Fraitag S, Hadj-Rabia S, Bodemer C, de Prost Y, Hamel-Teillac D: Clinical spectrum of tufted angiomas in childhood: a report of 13 cases and a review of the literature. Arch Dermatol; 2010 Jul;146(7):758-63
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  • BACKGROUND: Tufted angioma (TA) is a rare benign vascular tumor that mostly appears during infancy or early childhood.
  • Histologic tufts of capillaries infiltrating the whole dermis in a "cannonball" distribution pattern associated with dilated lymphatic vessels are characteristic of the disease and confirm the diagnosis.
  • Presentation was a nascent or florid tumor, usually a dusky red to violaceous plaque, that was indurated, firm, and sometimes associated with hyperhidrosis or hypertrichosis.
  • [MeSH-major] Hemangioma / pathology. Skin / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Male. Retrospective Studies. Young Adult

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  • (PMID = 20644037.001).
  • [ISSN] 1538-3652
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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65. Rajesh, Bist SS, Saxena RK: Deviated nasal septum in case of Klippel-Trenaunay-Weber Syndrome. Indian J Otolaryngol Head Neck Surg; 2006 Jul;58(3):298-9

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  • It includes cutaneous hemangioma (Port-wine stains) of the face and extremities with associated varicosities and hypertrophy of underlying soft tissue and bone.
  • These patients can have involvement of oral cavity and nasal mucosa with angiomatous malformation, which can give rise to epistaxis and excessive bleeding during oral and nasal surgeries.

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  • (PMID = 23120322.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3450391
  • [Keywords] NOTNLM ; Klippel-Trenaunay-Weber Syndrome / cutaneous hemangioma / deviated nasal septum / varicose vein
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66. O-Lee TJ, Messner A: Subglottic hemangioma. Otolaryngol Clin North Am; 2008 Oct;41(5):903-11, viii-ix
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  • [Title] Subglottic hemangioma.
  • Subglottic hemangioma is a rare condition that can be potentially life threatening because of airway obstruction.
  • It is common for subglottic hemangioma to be misdiagnosed as croup initially.
  • Infants with a subglottic hemangioma and cutaneous facial hemangiomas in a "beard" distribution should be evaluated for PHACE syndrome.
  • Endoscopic laser resection is effective for subglottic hemangioma but carries a chance of subglottic stenosis, up to 25%.
  • Open excision of subglottic hemangioma is an excellent option, particularly in patients with bilateral or circumferential subglottic hemangioma.
  • [MeSH-major] Hemangioma / diagnosis. Hemangioma / therapy. Laryngeal Neoplasms / diagnosis. Laryngeal Neoplasms / therapy

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  • (PMID = 18775341.001).
  • [ISSN] 0030-6665
  • [Journal-full-title] Otolaryngologic clinics of North America
  • [ISO-abbreviation] Otolaryngol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Glucocorticoids
  • [Number-of-references] 25
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67. Zhang Z, Chen HJ, Yang WJ, Bu H, Wei B, Long XY, Fu J, Zhang R, Ni YB, Zhang HY: Infantile hepatic hemangioendothelioma: a clinicopathologic study in a Chinese population. World J Gastroenterol; 2010 Sep 28;16(36):4549-57
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  • The tumor was presented with different clinical manifestations, mainly as an asymptomatic, palpable, upper abdominal mass, except for the two fetuses who were detected antenatally by ultrasound.
  • No symptoms of congestive heart failure were present and neither congenital abnormalities nor vascular tumors in the skin or other organs were found.
  • Based on radiological findings and gross specimens, the tumor presented as a solitary lesion or a multifocal space-occupying lesion.
  • The tumor size ranged from 5.0 cm × 3.5 cm × 2.0 cm to 13.8 cm × 9.0 cm × 7.7 cm, and the 0.2-1.1 cm nodules were diffusely distributed within the multifocal tumor.
  • An inflammatory component, predominantly eosinophilic granulocytes, sometimes obscured the nature of the tumor.

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  • (PMID = 20857525.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2945486
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68. Boutarbouch M, Ben Salem D, Giré L, Giroud M, Béjot Y, Ricolfi F: Multiple cerebral and spinal cord cavernomas in Klippel-Trenaunay-Weber syndrome. J Clin Neurosci; 2010 Aug;17(8):1073-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Klippel-Trenaunay-Weber syndrome (KTWS) is a rare syndrome in which patients harbor cutaneous hemangiomas, venous varicosities, and osseous-soft tissue hypertrophy of the affected limb.
  • [MeSH-major] Cerebral Cortex / pathology. Hemangioma, Cavernous, Central Nervous System / complications. Klippel-Trenaunay-Weber Syndrome / complications. Spinal Cord / pathology

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  • [Copyright] Copyright 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20493710.001).
  • [ISSN] 1532-2653
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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69. Metry D, Heyer G, Hess C, Garzon M, Haggstrom A, Frommelt P, Adams D, Siegel D, Hall K, Powell J, Frieden I, Drolet B, PHACE Syndrome Research Conference: Consensus Statement on Diagnostic Criteria for PHACE Syndrome. Pediatrics; 2009 Nov;124(5):1447-56
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVES: A subgroup of patients with infantile hemangiomas have associated structural anomalies of the brain, cerebral vasculature, eyes, sternum, and/or aorta in the neurocutaneous disorder known as PHACE syndrome.
  • The diagnosis has been broadly inclusive by using a case definition of a facial hemangioma plus >or=1 extracutaneous features, leading to numerous reports of potential associated disease features, many of uncertain significance.
  • Definite PHACE requires the presence of a characteristic segmental hemangioma or hemangioma >5 cm on the face or scalp plus 1 major criterion or 2 minor criteria.
  • Possible PHACE requires the presence of a hemangioma >5 cm on the face or scalp plus 1 minor criterion.
  • The group recognized that it may be possible to have PHACE syndrome with a hemangioma affecting the neck, chest, or arm only or no cutaneous hemangioma at all.
  • In such cases, fulfillment of additional required criteria would also lead to a possible PHACE diagnosis.
  • [MeSH-major] Abnormalities, Multiple / diagnosis. Head and Neck Neoplasms / diagnosis. Hemangioma / diagnosis. Neurocutaneous Syndromes / diagnosis
  • [MeSH-minor] Aorta / abnormalities. Brain / abnormalities. Eye Abnormalities / diagnosis. Humans. Infant. Sternum / abnormalities. Syndrome


70. Dourmishev LA, Dourmishev AL: Craniofacial cavernous hemangioma: succesful treatment with methylprednisolone. Acta Dermatovenerol Alp Pannonica Adriat; 2005 Jun;14(2):49-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Craniofacial cavernous hemangioma: succesful treatment with methylprednisolone.
  • Systemic corticosteroid treatment is reported as effective for problematic cutaneous hemangiomas occuring in infancy, and depend on the dose, the duration of treatment, and the age at which the course of drugs is initiated.
  • A 7-month-old female infant with extended cavernous hemangioma on the left part of forehead, face,and neck which appeared 15 days after birth is presented.
  • The oral corticosteroid treatment is an efficient medical therapy for common extended cavernous infantile hemangiomas with accelerated growth if initiated early in the proliferative phase.
  • [MeSH-major] Craniofacial Abnormalities / drug therapy. Glucocorticoids / therapeutic use. Hemangioma, Cavernous / drug therapy. Methylprednisolone / therapeutic use


71. Taddeucci G, Bonuccelli A, Polacco P: Migraine-like attacks in child with Sturge-Weber syndrome without facial nevus. Pediatr Neurol; 2005 Feb;32(2):131-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Migraine-like attacks in child with Sturge-Weber syndrome without facial nevus.
  • The Sturge-Weber syndrome was recently subdivided into type I (facial and leptomeningeal angioma, possible glaucoma), type II (facial angioma, without evident endocranial involvement), and type III (exclusive leptomeningeal angioma).
  • This study presents a case of a 2-year 9-month-old child with normal psychomotor development and skin free (no angiomas), who presented repeated episodes of severe headache, vertiginous symptoms, vomiting, and drowsiness, separated by complete recovery.
  • The cranial computed tomography and magnetic resonance imaging with gadolinium revealed left occipital leptomeningeal angiomatosis with calcifications, suggesting a diagnosis of Sturge-Weber syndrome type III.
  • Considering the normal psychomotor development, the improved electroencephalographic reports between the episodes, and the absence of hypoperfusion areas on single-photon emission computed tomography at 30 months of follow-up, the symptomatology appears an expression of migraine-like symptoms resulting from vasomotor disturbances within and around the angioma, more than an expression of partial seizures arising through an epileptic focus in the ischemic region around the vascular malformation.


72. López V, Martín JM, Monteagudo C, Jordá E: [Epidemiology of pediatric dermatologic surgery: a retrospective study of 996 children]. Actas Dermosifiliogr; 2010 Nov;101(9):771-7
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  • [Transliterated title] Epidemiología de la cirugía dermatológica pediátrica. Un estudio retrospectivo de 996 niños.
  • OBJECTIVE: To describe the epidemiology of skin surgery performed in the dermatology department of Hospital Clínico Universitario in Valencia, Spain, on children up to 16 years of age.
  • The following data were collected: age, sex, surgical site, and histopathologic diagnosis.
  • The most common diagnosis was melanocytic nevus (50.20%), followed by pilomatrixoma (4.62%), capillary angioma (3.61%), epidermal cyst (3.61%), Spitz nevus (3.31%), and pyogenic granuloma (3.11%).
  • Most children had benign lesions, with melanocytic nevus being by far the most common diagnosis.
  • [MeSH-major] Skin Diseases / surgery
  • [MeSH-minor] Adolescent. Biopsy / utilization. Child. Child, Preschool. Cysts / epidemiology. Cysts / surgery. Female. Hemangioma, Capillary / epidemiology. Hemangioma, Capillary / surgery. Hospitals, University / statistics & numerical data. Humans. Infant. Male. Nevus, Pigmented / epidemiology. Nevus, Pigmented / surgery. Pyoderma Gangrenosum / epidemiology. Pyoderma Gangrenosum / surgery. Retrospective Studies. Skin / pathology. Skin Neoplasms / diagnosis. Skin Neoplasms / epidemiology. Skin Neoplasms / pathology. Skin Neoplasms / surgery. Spain / epidemiology. Surgery, Plastic

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  • (PMID = 21034707.001).
  • [ISSN] 1578-2190
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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73. O TM, Alexander RE, Lando T, Grant NN, Perkins JA, Blitzer A, Waner M: Segmental hemangiomas of the upper airway. Laryngoscope; 2009 Nov;119(11):2242-7
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  • [Title] Segmental hemangiomas of the upper airway.
  • OBJECTIVES/HYPOTHESIS: To characterize the anatomic distribution of segmental hemangiomas of the larynx and to describe indications for treatment modalities.
  • METHODS: We performed a retrospective chart review of patients with cutaneous hemangiomas at a tertiary care center over a 4-year period.
  • Only patients with upper airway hemangiomas were studied.
  • We reviewed the anatomic distribution of hemangiomas within the upper airway and the treatment course of each patient.
  • RESULTS: Of 1,226 patients with cutaneous hemangiomas, 108 (9%) were segmental in distribution.
  • All of these patients had associated V3 or mandibular segmental hemangiomas.
  • As with the cutaneous manifestation, the distribution of hemangioma within the upper airway was segmental.
  • CONCLUSIONS: A high percentage of patients with V3 cutaneous hemangiomas (29%) will manifest with upper airway involvement, the distribution of which is segmental.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Hemangioma / pathology. Skin Neoplasms / pathology

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  • (PMID = 19806648.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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74. Salvati M, D'Elia A, Melone GA, Brogna C, Frati A, Raco A, Delfini R: Radio-induced gliomas: 20-year experience and critical review of the pathology. J Neurooncol; 2008 Sep;89(2):169-77
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  • Irradiation had initially been given for acute lymphoblastic leukemia (ALL) in six cases, tinea capitis in four cases, scalp hemangioma in three cases, cutaneous hemangioma, cavernous angioma, and medulloblastoma in one case each.

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  • (PMID = 18566750.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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75. Al-Za'abi AM, Ghazarian D, Greenberg GR, Shaw JC: Eruptive tufted angiomas in a patient with Crohn's disease. J Clin Pathol; 2005 Feb;58(2):214-6
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  • Angioblastoma is a rare, benign vascular tumour composed of undifferentiated mesenchymal cells with a tendency to form lumina.
  • This entity was first described by Nakagawa in 1949 as angioblastoma, and Wilson Jones was the first to use the term "tufted angioma" in 1976.
  • He developed numerous small itchy erythematous vascular appearing papules, which on histological examination resembled tufted angiomas, showing the classic "cannon ball" appearance.
  • This case may represent an eruptive acquired tufted angioma in which immunosuppression or drug induced modification of angiogenesis played a role in its development and regression.
  • One previous case of eruptive tufted angioma has been reported in an immunosuppressed patient.
  • [MeSH-major] Crohn Disease / pathology. Hemangioma / pathology. Skin Neoplasms / pathology

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  • (PMID = 15677546.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Gastrointestinal Agents; B72HH48FLU / Infliximab
  • [Other-IDs] NLM/ PMC1770572
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76. Jin SP, Chang MS, Shin HS, Kim BY, Park HJ, Won CH, Cho SY: Eruptive pseudo-angiomatosis lesions are associated with intravascular neutrophils and do not harbour Epstein-Barr virus. J Eur Acad Dermatol Venereol; 2010 Feb;24(2):163-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Eruptive pseudo-angiomatosis (EPA) is a rare, relatively newly described cutaneous disorder characterized by the sudden onset of several bright red, angioma-like papules surrounded by blanched halo.
  • Skin biopsies demonstrated capillary ectasia with perivascular mononuclear cellular infiltrates in the upper dermis.
  • The skin lesions faded without any treatment in 1-2 weeks.

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  • (PMID = 19614858.001).
  • [ISSN] 1468-3083
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / RNA, Viral
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77. Ganguly R, Mukherjee A: Infantile hemangioendothelioma: A case report and discussion. Pathol Res Pract; 2010 Jan 15;206(1):53-8
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  • Various presentations of this lesion have been reported in the literature, e.g. cases with a hepatic mass, cutaneous hemangiomas, heart failure, etc.
  • The two jejunal masses and the hepatic lesion were diagnosed as angiosarcoma histomorphologically (IHHE type II), and were positive for vascular markers (CD31 and CD34) on immunohistochemistry.
  • The patient had no skin lesions.

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  • [Copyright] Copyright 2009 Elsevier GmbH. All rights reserved.
  • (PMID = 19321270.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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78. Alli SK, Adenuga OO, Ogbuagu MN, Velle LD, Akinyemi AO: Sturge-Weber syndrome in a 56 year old woman: a case report. Niger J Med; 2005 Jul-Sep;14(3):319-21
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  • BACKGROUND: Sturge-Weber syndrome is a sporadic phacomatoses with angiomas involving the leptomeninges and skin of the face, typically in the ophthalmic and maxillary distributions of the trigeminal nerve.
  • Presentation is typically at birth with a facial angioma.
  • METHOD: Case note of a patient with a diagnosis of Sturge-Weber syndrome was used and the relevant literature reviewed.
  • Examination of the left eye revealed a visual acuity of no light perception with episcleral haemangioma.
  • [MeSH-major] Sturge-Weber Syndrome / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Middle Aged

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  • (PMID = 16350708.001).
  • [ISSN] 1115-2613
  • [Journal-full-title] Nigerian journal of medicine : journal of the National Association of Resident Doctors of Nigeria
  • [ISO-abbreviation] Niger J Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Nigeria
  • [Number-of-references] 12
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79. Hernández F, Navarro M, Encinas JL, López Gutiérrez JC, López Santamaría M, Leal N, Martínez L, Patrón M, Tovar JA: The role of GLUT1 immunostaining in the diagnosis and classification of liver vascular tumors in children. J Pediatr Surg; 2005 May;40(5):801-4
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  • [Title] The role of GLUT1 immunostaining in the diagnosis and classification of liver vascular tumors in children.
  • BACKGROUND/AIM: GLUT1 is an erythrocyte-type glucose transporter protein typically expressed in cutaneous proliferating hemangioma.
  • Immunostaining for GLUT1 is becoming valuable for predicting the outcome of vascular skin tumors.
  • Liver vascular tumors (LVTs) are a serious challenge for pediatric surgeons because of their often severe and sometimes unpredictable clinical course.
  • Patients were divided into 2 groups: GLUT1-positive (n = 4) and GLUT1-negative (n = 7) that were compared for age at diagnosis, survival, and proportion of proliferating cells.
  • RESULTS: Mean age at diagnosis was higher in GLUT1-positive group, although not statistically significant in comparison with GLUT1-negative (308 +/- 515 vs 70 +/- 51 days, respectively).
  • All GLUT1-positive tumors were multicentric hemangiomata without central necrosis and only 1 with large vessels.
  • Among GLUT1-negative tumors, 5 were solitary masses and 2 were multicentric (the value of the last 2 specimens was uncertain), 2 had central necrosis, and 2 had large vessels.
  • CONCLUSIONS: GLUT1-positive tumors have significantly higher proliferation rates than negative ones.
  • Mortality tended to be higher in children with GLUT1-positive tumors.
  • Positive GLUT1 immunostaining is likely specific for proliferating hemangioma, and it predicts the typical course of proliferation followed by involution.
  • [MeSH-major] Biomarkers, Tumor / analysis. Glucose Transporter Type 1 / analysis. Hemangioma / chemistry. Liver Neoplasms / chemistry. Neoplasm Proteins / analysis
  • [MeSH-minor] Antibodies, Monoclonal / immunology. Child, Preschool. Diagnostic Errors. Hemangioendothelioma / chemistry. Hemangioendothelioma / diagnosis. Hemangioendothelioma / pathology. Hemangioendothelioma / surgery. Hemangiosarcoma / chemistry. Hemangiosarcoma / diagnosis. Hemangiosarcoma / pathology. Hemangiosarcoma / surgery. Humans. Immunohistochemistry. Infant. Infant, Newborn. Ki-67 Antigen / analysis. Liver Transplantation. Mitotic Index. Necrosis. Neoplasms, Multiple Primary / chemistry. Neoplasms, Multiple Primary / congenital. Neoplasms, Multiple Primary / mortality. Neoplasms, Multiple Primary / pathology. Retrospective Studies

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  • (PMID = 15937818.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Biomarkers, Tumor; 0 / Glucose Transporter Type 1; 0 / Ki-67 Antigen; 0 / Neoplasm Proteins; 0 / SLC2A1 protein, human
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80. Chen ZX, Shan SG, Zhang DL, Liu J, Yang Y: [The expression of p73 and c-fos protein in hemangioma and its significance]. Zhonghua Zheng Xing Wai Ke Za Zhi; 2005 Jan;21(1):47-9
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  • [Title] [The expression of p73 and c-fos protein in hemangioma and its significance].
  • OBJECTIVE: To investigate the expression of p73 and c-fos protein and its significance in the development of children hemangioma.
  • METHODS: The quantitative expressions of p73 and c-fos protein in hemangioma and normal skin were detected by immunohistochemistry.
  • RESULTS: The expressions of p73 and c-fos protein were strong in proliferative hemangioma while they were very weak in involutional hemangioma and normal skin.
  • There were significant differences between the proliferative and involutional hemangioma or the normal skin in the expressions of p73 and c-fos (P < 0.01).
  • No statistical significances of p73 or c-fos P73 expressions were observed between involutional hemangioma and normal skin (P > 0.05).
  • CONCLUSIONS: P73 and c-fos may play an important role in the development and involution of skin hemangioma.
  • [MeSH-major] DNA-Binding Proteins / metabolism. Hemangioma / metabolism. Nuclear Proteins / metabolism. Proto-Oncogene Proteins c-fos / metabolism. Tumor Suppressor Proteins / metabolism

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  • (PMID = 15844599.001).
  • [ISSN] 1009-4598
  • [Journal-full-title] Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery
  • [ISO-abbreviation] Zhonghua Zheng Xing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / Nuclear Proteins; 0 / Proto-Oncogene Proteins c-fos; 0 / Tumor Suppressor Proteins; 0 / tumor suppressor protein p73
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81. Fulkerson DH, Agim NG, Al-Shamy G, Metry DW, Izaddoost SA, Jea A: Emergent medical and surgical management of mediastinal infantile hemangioma with symptomatic spinal cord compression: case report and literature review. Childs Nerv Syst; 2010 Dec;26(12):1799-805
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  • [Title] Emergent medical and surgical management of mediastinal infantile hemangioma with symptomatic spinal cord compression: case report and literature review.
  • PURPOSE: We report an extremely rare case of a patient with a large, cervical, and upper thoracic cutaneous hemangioma associated with a separate, underlying mediastinal hemangioma extending to the epidural space causing significant spinal cord compression.
  • CONCLUSION: While several recent reports have described dramatic responses of hemangiomas to propranolol, this is the first case in which it was used as part of a multimodal approach to symptomatic spinal cord compression.
  • She is neurologically intact and has radiographic regression of the hemangiomas on follow-up examination 6 months later.
  • [MeSH-major] Decompression, Surgical / adverse effects. Hemangioma, Capillary / drug therapy. Hemangioma, Capillary / surgery. Mediastinal Neoplasms / drug therapy. Mediastinal Neoplasms / surgery. Spinal Cord Compression / surgery

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  • (PMID = 20405131.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Adrenergic beta-Antagonists; 0 / Anti-Inflammatory Agents; 0 / Anticoagulants; 9005-49-6 / Heparin; 9PHQ9Y1OLM / Prednisolone; 9Y8NXQ24VQ / Propranolol
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82. Duffy KJ, Runge-Samuelson C, Bayer ML, Friedland D, Sulman C, Chun R, Kerschner JE, Metry D, Adams D, Drolet BA: Association of hearing loss with PHACE syndrome. Arch Dermatol; 2010 Dec;146(12):1391-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: PHACE syndrome describes a spectrum of anomalies associated with large facial infantile hemangiomas and characterized by posterior fossa malformations, hemangiomas, arterial anomalies, coarctation of the aorta and cardiac defects, and eye abnormalities.
  • Four of the 6 patients had magnetic resonance imaging features of lesions consistent with intracranial hemangiomas involving auditory structures.
  • All 6 patients had facial hemangiomas in a nearly identical distribution ipsilateral to the ear with the hearing loss, with involvement of the proposed facial segments S1 and S3, the affected ear, the periauricular region, and the midoccipital area of the scalp.
  • Patients with PHACE syndrome who have cutaneous hemangiomas involving the ear should be evaluated for intracranial hemangiomas and monitored for hearing loss.
  • Early detection and therapy of intracranial hemangiomas may slow or stop tumor growth, resultant hearing loss, and structural damage.
  • [MeSH-minor] Acoustic Impedance Tests. Aortic Coarctation / complications. Aortic Coarctation / diagnosis. Diagnosis, Differential. Eye Abnormalities / complications. Eye Abnormalities / diagnosis. Female. Follow-Up Studies. Humans. Infant, Newborn. Magnetic Resonance Imaging. Neurocutaneous Syndromes / complications. Neurocutaneous Syndromes / diagnosis. Otoacoustic Emissions, Spontaneous. Syndrome

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  • (PMID = 20713775.001).
  • [ISSN] 1538-3652
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Grant] United States / NIDCD NIH HHS / DC / K23DC008837
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] PHACE association
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83. Onesti MG, Trignano E, Fino P, Scuderi N: Neuro-ocular cutaneous syndrome: a case report. G Ital Dermatol Venereol; 2009 Aug;144(4):487-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Neuro-ocular cutaneous syndrome: a case report.
  • Neuro-ocular cutaneous syndrome is a rare and little-known illness.
  • It affects the ocular apparatus, the nervous system and the skin.
  • The disease causes pathologies such as phacomatosis, which is a generic term used to describe small cutaneous neoformations, as well as other ectodermal organ malformations (ocular apparatus and central nervous system).
  • The symptoms of this disease are ocular, neurological and dermatological and can include: corneal opacity, papillary coloboma, optical atrophy, epibulbar dermoids, corectopia, palpebral coloboma, frontoparietal alopecia, epilepsy, psychomotor delay, pedunculated skin growths, a yellowing of the frontal area, milled papules, milled patches of skin, cutaneous spotting, familial angioma and hemiplegia.
  • The clinical case of a 15 year-old patient (who was diagnosed at 10 months old) affected by the neuro-ocular cutaneous syndrome will be discussed below.

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  • (PMID = 19755953.001).
  • [ISSN] 0392-0488
  • [Journal-full-title] Giornale italiano di dermatologia e venereologia : organo ufficiale, Società italiana di dermatologia e sifilografia
  • [ISO-abbreviation] G Ital Dermatol Venereol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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84. Breysem L, Allewaert S, Claus F, De Beer A, Van Geet C, Rayyan M, Smet MH: The use of duplex doppler ultrasound in a case of multifocal hepatic hemangioma. JBR-BTR; 2008 Jul-Aug;91(4):145-8
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  • [Title] The use of duplex doppler ultrasound in a case of multifocal hepatic hemangioma.
  • A one-month-old girl presented with multiple cutaneous hemangiomas, abnormal weight gain, hepatomegaly, and symptoms of bleeding disorder.
  • Abdominal ultrasound and CT revealed a multifocal hypervascular hepatic tumor and signs of vascular overload.
  • Biopsy confirmed the presence of an infantile hepatic hemangioma.
  • Conservative treatment with high dose steroids showed regression of the hepatic lesions and the signs of vascular congestion.
  • [MeSH-major] Hemangioma / ultrasonography. Liver Neoplasms / ultrasonography. Neoplasms, Multiple Primary / ultrasonography. Ultrasonography, Doppler, Duplex
  • [MeSH-minor] Contrast Media. Female. Humans. Infant. Skin Neoplasms / congenital. Tomography, X-Ray Computed

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  • (PMID = 18817086.001).
  • [ISSN] 0302-7430
  • [Journal-full-title] JBR-BTR : organe de la Société royale belge de radiologie (SRBR) = orgaan van de Koninklijke Belgische Vereniging voor Radiologie (KBVR)
  • [ISO-abbreviation] JBR-BTR
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
  • [Chemical-registry-number] 0 / Contrast Media
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85. Enjolras O, Picard A, Soupre V: [Congenital haemangiomas and other rare infantile vascular tumours]. Ann Chir Plast Esthet; 2006 Aug-Oct;51(4-5):339-46
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  • [Title] [Congenital haemangiomas and other rare infantile vascular tumours].
  • GLUT1 stains 100% of infantile haemangiomas and none of the other infantile vascular tumours.
  • Congenital haemangiomas represent a group of vascular tumours still under evaluation as they have slightly heterogeneous presentation.
  • Some of them (RICH--Rapidly Involuting Congenital Haemangioma) undergo spontaneous involution during the first year.
  • Others (NICH--Non Involuting Congenital Haemangioma) persist lifelong.
  • Tufted angioma and kaposiform haemangioendothelioma are histopathologically well characterized; in addition they are now considered as part of a same spectrum of vascular tumours, with the contribution of lymphatic endothelial cells in their proliferation.
  • [MeSH-major] Hemangioma / congenital. Neoplasms, Vascular Tissue / diagnosis. Skin Neoplasms / congenital
  • [MeSH-minor] Biomarkers, Tumor / analysis. Blood Platelets / pathology. Child. Disseminated Intravascular Coagulation / diagnosis. Glucose Transporter Type 1 / analysis. Hemangioendothelioma / diagnosis. Hemangioma, Capillary / congenital. Humans. Infant. Prognosis. Remission, Spontaneous. Syndrome. Thrombocytopenia / diagnosis

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  • (PMID = 16997442.001).
  • [ISSN] 0294-1260
  • [Journal-full-title] Annales de chirurgie plastique et esthétique
  • [ISO-abbreviation] Ann Chir Plast Esthet
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Glucose Transporter Type 1; 0 / SLC2A1 protein, human
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86. Priestnall SL, De Bellis F, Bond R, Alony-Gilboa Y, Summers BA: Spontaneous regression of congenital cutaneous hemangiomas in a calf. Vet Pathol; 2010 Mar;47(2):343-5
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  • [Title] Spontaneous regression of congenital cutaneous hemangiomas in a calf.
  • Congenital vascular tumors of the skin have been described in people and a few animals, but unlike infantile hemangiomas in children, spontaneous regression has not been described in animals.
  • A 2-day-old male Belgian Blue cross calf was presented for multiple congenital cutaneous masses that were soft, alopecic, and hyperemic; the calf had no other apparent abnormalities.
  • Surgical excision of one of the remaining masses was performed; histopathologic and immunohistochemical findings were considered diagnostic for epithelioid hemangioma.
  • This constitutes the first account in the veterinary literature of spontaneous regression in a congenital vascular tumor.
  • [MeSH-major] Cattle Diseases / pathology. Hemangioma / veterinary. Neoplasm Regression, Spontaneous / pathology. Skin Neoplasms / veterinary

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  • (PMID = 20118321.001).
  • [ISSN] 1544-2217
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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87. Musumeci ML, Schlecht K, Perrotta R, Schwartz RA, Micali G: Management of cutaneous hemangiomas in pediatric patients. Cutis; 2008 Apr;81(4):315-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Management of cutaneous hemangiomas in pediatric patients.
  • Cutaneous hemangiomas (CHs) are common benign vascular tumors of childhood.
  • [MeSH-major] Hemangioma / therapy. Skin Neoplasms / therapy

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  • (PMID = 18491478.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 89
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88. Ardighieri L, Lonardi S, Vermi W, Medicina D, Cerroni L, Facchetti F: Intralymphatic atypical T-cell proliferation in a cutaneous hemangioma. J Cutan Pathol; 2010 Apr;37(4):497-503
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  • [Title] Intralymphatic atypical T-cell proliferation in a cutaneous hemangioma.
  • We report an unusual case of atypical T-cell proliferation involving the lymphatic vessels within a cutaneous hemangioma from an elderly woman.
  • Despite the blastic morphology, the CD4 restricted phenotype and the very high proliferation index, the clinical presentation (single skin lesion in a healthy woman), the benign clinical course and the absence of T-cell receptor (TCR) clonal rearrangement favored a reactive nature of the process.
  • [MeSH-major] Cell Proliferation. Hemangioma / immunology. Lymph Nodes / immunology. Skin Neoplasms / immunology. T-Lymphocytes / immunology

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  • (PMID = 19614995.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Forkhead Transcription Factors; 0 / Receptors, Antigen, T-Cell
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89. Johnson WD, Petrie MM: Variety of spinal vascular pathology seen in adult Cobb syndrome. J Neurosurg Spine; 2009 May;10(5):430-5
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  • [Title] Variety of spinal vascular pathology seen in adult Cobb syndrome.
  • Cobb syndrome is a rare clinical entity that includes the combination of a vascular skin nevus and an angioma in the spinal canal present at identical dermatomal level(s) (cutaneomeningospinal angiomatosis).
  • The majority of these cases have been described in the era predating current neuroimaging techniques, and most authors have assumed that each case involves similar vascular pathology.
  • This report highlights 2 patients presenting with similar thoracic cutaneous vascular nevi yet with markedly differing spinal vascular pathology.
  • A 29-year-old man presented with cutaneous hemangioma and a progressive paraparesis and paresthesia of the lower extremities.
  • Workup for each patient included pre- and postoperative contrast-enhanced MR imaging with vascular sequencing and spinal angiography.
  • Cobb syndrome is an unusual entity in the adult population and should be considered when there is a constellation of cutaneous manifestation and underlying neurological deficit.
  • The vascular skin nevus associated with Cobb syndrome is accompanied by a wide variety of vascular pathologies.
  • [MeSH-major] Hemangioma / pathology. Nevus / pathology. Skin Neoplasms / pathology. Spinal Canal. Spinal Neoplasms / pathology

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  • (PMID = 19442004.001).
  • [ISSN] 1547-5654
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 18
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90. Romeo F, Toscano S, Santangelo M, Fumai V, Maddalena G: Spontaneous cervical extradural hematoma in a cutaneo-meningospinal angiomatosis (Cobb syndrome): case report. J Neurosurg Sci; 2009 Jun;53(2):59-61
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  • [Title] Spontaneous cervical extradural hematoma in a cutaneo-meningospinal angiomatosis (Cobb syndrome): case report.
  • Spontaneous spinal extradural hematoma is a rare clinical entity, commonly associated with coagulopathies, tumours or vascular malformations.
  • They are often a neurosurgical emergency, therefore prompt diagnosis and early treatment are necessary.
  • The Cobb syndrome is a neurocutaneous syndrome in which there are metameric vascular skin nevus and spinal arteriovenous malformation.
  • The authors report the case of a 52-year-old woman with acute cervical myelopathy and a cervical cutaneous hemangioma on clinical examination.
  • It is stressed the importance of clinical suspicion of cutaneo-meningospinal angiomatosis based on a spinal cord syndrome in the presence of a vascular skin nevus of the same metameric level.
  • [MeSH-major] Angiomatosis / complications. Arteriovenous Malformations / complications. Hematoma, Epidural, Cranial / etiology. Nevus / complications. Skin Neoplasms / complications

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  • (PMID = 19546845.001).
  • [ISSN] 0390-5616
  • [Journal-full-title] Journal of neurosurgical sciences
  • [ISO-abbreviation] J Neurosurg Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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91. Deng ZH, Xu CD, Chen SN: Diagnosis and treatment of blue rubber bleb nevus syndrome in children. World J Pediatr; 2008 Feb;4(1):70-3
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  • [Title] Diagnosis and treatment of blue rubber bleb nevus syndrome in children.
  • BACKGROUND: Blue rubber bleb nevus syndrome (BRBNS) is characterized by distinctive vascular malformations of skin and the gastrointestinal tract, often leading to chronic anemia and intestinal bleeding.
  • We analyzed the clinical characteristics and treatment of this disorder in order to improve the diagnosis and treatment.
  • METHODS: Three patients with BRBNS treated at our hospital during 2002-2003 and 39 patients from the literature reported during 1965-2003 were reviewed in terms of the diagnosis and treatment.
  • BRBNS may be diagnosed as cutaneous cavernous hemangioma associated with the same lesion of the gastrointestinal tract and other organs.
  • RESULTS: Our 3 patients suffered from cutaneous angioma and gastrointestinal hemangioma.
  • In 39 patients reported in the literature, cutaneous angioma was observed in all of them, and gastrointestinal hemangioma in 31.
  • Cutaneous angioma was located on the surface of the skin, including body (93%), limbs (86%), hip (36%) and face (26%).
  • Gastrointestinal hemangioma was more common in the small intestine (100%) than in the colon (74%) and stomach (26%).
  • When the joint was involved by hemangioma, pathologic fracture or overgrowth of bone needed traction and amputation (1 patient respectively).
  • Its recurrence with new angioma in the gastrointestinal tract needs laser-steroid therapy.
  • [MeSH-major] Hemangioma / diagnosis. Intestinal Neoplasms / diagnosis. Skin Neoplasms / diagnosis. Vascular Malformations / diagnosis
  • [MeSH-minor] Abnormalities, Multiple / diagnosis. Blood Transfusion. Child. Child, Preschool. Endoscopy, Gastrointestinal. Humans. Male. Melena / etiology. Nevus, Blue. Sclerotherapy. Syndrome

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  • (PMID = 18402258.001).
  • [ISSN] 1708-8569
  • [Journal-full-title] World journal of pediatrics : WJP
  • [ISO-abbreviation] World J Pediatr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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92. Yang JI, Kim HS, Ryu HS: Prenatal sonographic diagnosis of Klippel-Trenaunay-Weber syndrome: a case report. J Reprod Med; 2005 Apr;50(4):291-4
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  • [Title] Prenatal sonographic diagnosis of Klippel-Trenaunay-Weber syndrome: a case report.
  • BACKGROUND: Klippel-Trenaunay-Weber syndrome is a rare congenital soft tissue anomaly with sporadic occurrence characterized by the triad of multiple hemangiomas, arteriovenous fistulas and unilateral limb hypertrophy.
  • On prenatal sonography, multiloculated cystic areas involving the left side of the thorax and hypertrophy of the upper portion of the left arm were diagnosed without diagnostic findings on color flow Doppler studies of the cutaneous hemangioma.
  • CONCLUSION: Klippel-Trenaunay-Weber syndrome should be considered in the differential diagnosis of a fetal thoracic mass even if color flow Doppler studies of the mass are negative.

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  • (PMID = 15916215.001).
  • [ISSN] 0024-7758
  • [Journal-full-title] The Journal of reproductive medicine
  • [ISO-abbreviation] J Reprod Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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93. Jiang XW, Wang GH, Li JH, Chen ZX, He F: Expression of glucocorticoid receptor isoforms in cutaneous hemangiomas and vascular malformations. Chin Med J (Engl); 2005 Jun 20;118(12):977-81
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  • [Title] Expression of glucocorticoid receptor isoforms in cutaneous hemangiomas and vascular malformations.
  • BACKGROUND: Hemangiomas are the most common tumors in children.
  • Some hemangiomas may require intervention because of their location, size, behavior, or potential for important complications.
  • This study was performed to investigate the expression patterns of the glucocorticoid receptor (GR) and its alpha isoform (GRalpha) in cutaneous hemangiomas and vascular malformations.
  • METHODS: SP immunohistochemical technique was used to examine the expression of GR(e-20) (GR) and GR(p-20) (GRalpha) on vascular endothelial cells in 80 specimens that included 33 proliferating hemangiomas, 32 involuting hemangiomas, 7 vascular malformations as well as 8 normal skin tissues, all obtained from infants and children.
  • Mean gray scale values were compared among the various tumor types.
  • RESULTS: The mean gray scale values of GR were 127.0 +/- 6.4 and 121.4 +/- 6.6 in hemangiomas and vascular malformations respectively, but this difference was not statistically significant (P = 0.104).
  • However, these values were all markedly higher than that of normal skin, which was only 108.6 +/- 6.8 (P = 0.001 and P = 0.000 for comparison with hemangiomas and vascular malformations respectively).
  • The gray scale of GR in proliferation and involuting hemangiomas were 127.9 +/- 4.8 and 126.0 +/- 5.8 respectively, but this difference was not significant (P = 0.146).
  • However, GRalpha expression in hemangiomas, vascular malformations and normal skin declined gradually in stepwise fashion (127.3 +/- 5.4, 120.4 +/- 6.1 and 109.9 +/- 5.3 respectively; P < 0.001).
  • GRalpha expression was higher in proliferating hemangiomas than in involuting hemangiomas (127.2 +/- 6.3 and 122.5 +/- 6.3; P = 0.004).
  • CONCLUSIONS: GR and GRalpha are strongly expressed in hemangiomas and vascular malformations.
  • The expression of GRalpha is closely related to the phase of the hemangioma.
  • Determination of GR and GRalpha may be a positive significance to understand the information of hemangiomas and vascular malformations and may further help determining proper strategies of steroid therapy for hemangiomas and vascular malformations.
  • [MeSH-major] Blood Vessels / abnormalities. Hemangioma / chemistry. Receptors, Glucocorticoid / analysis. Skin Neoplasms / chemistry

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  • (PMID = 15978204.001).
  • [ISSN] 0366-6999
  • [Journal-full-title] Chinese medical journal
  • [ISO-abbreviation] Chin. Med. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Protein Isoforms; 0 / Receptors, Glucocorticoid; 0 / glucocorticoid receptor alpha
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94. Tokuyama W, Mikami T, Masuzawa M, Okayasu I: Autocrine and paracrine roles of VEGF/VEGFR-2 and VEGF-C/VEGFR-3 signaling in angiosarcomas of the scalp and face. Hum Pathol; 2010 Mar;41(3):407-14
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  • Angiosarcoma of the skin is an extremely rare malignant tumor of vascular origin that usually arises in the scalp and face of elderly persons.
  • To clarify its characteristic features and cell cycle kinetics, we quantitatively evaluated the expression of cell cycle-related molecules and vascular endothelial growth factors using immunohistochemical staining, for comparison with 2 benign vascular tumors of the skin, the capillary hemangioma and the cavernous hemangioma.
  • Cell proliferation, determined with reference to the Ki-67 labeling index, was highest in angiosarcomas and lowest in cavernous hemangiomas (angiosarcomas versus capillary hemangioma, P = .014; capillary hemangioma versus cavernous hemangiomas, P = 1.4 x 10(-4)).
  • Expressions of cyclin D1 and p16(INK4A) were also significantly higher in angiosarcoma than in cavernous hemangioma.
  • Expression levels of vascular endothelial growth factor and its receptor, VEGFR-2, were highest in angiosarcomas.
  • VEGF-C expression in angiosarcomas was significantly higher than in cavernous hemangiomas, and its receptor VEGFR-3 expression was highest in angiosarcomas.
  • These results suggest that not only VEGFR-2-mediated signal but also VEGFR-3-mediated signal may contribute to proliferation of vascular tumor cells as autocrine and paracrine signaling factors.
  • [MeSH-major] Head and Neck Neoplasms / metabolism. Hemangiosarcoma / metabolism. Scalp / metabolism. Vascular Endothelial Growth Factor A / metabolism. Vascular Endothelial Growth Factor C / metabolism. Vascular Endothelial Growth Factor Receptor-2 / metabolism. Vascular Endothelial Growth Factor Receptor-3 / metabolism

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 19913279.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclin A; 0 / Cyclin E; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Ki-67 Antigen; 0 / Vascular Endothelial Growth Factor A; 0 / Vascular Endothelial Growth Factor C; EC 2.7.10.1 / Vascular Endothelial Growth Factor Receptor-2; EC 2.7.10.1 / Vascular Endothelial Growth Factor Receptor-3
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95. Smolinski KN, Yan AC: Hemangiomas of infancy: clinical and biological characteristics. Clin Pediatr (Phila); 2005 Nov-Dec;44(9):747-66
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  • [Title] Hemangiomas of infancy: clinical and biological characteristics.
  • Hemangiomas of infancy are common in the general pediatric population, are usually easily diagnosed, and generally do not require treatment.
  • However, a small but significant percentage of hemangiomas of infancy may develop complications, including infection or ulceration.
  • In addition, hemangiomas located in some anatomic regions may be associated with other anomalies and therefore require more careful monitoring and earlier intervention to prevent permanent sequelae.
  • This review focuses on distinguishing hemangiomas from vascular malformations and delineates the natural history of hemangiomas of infancy, with an emphasis on identifying those hemangiomas that require additional evaluation and closer follow-up.
  • In addition, several conditions that often present with cutaneous hemangiomas are described, including PHACES syndrome and neonatal hemangiomatosis.
  • Finally, an assessment is made of the current understanding of the biology of hemangioma proliferation and involution, including the role of endothelial growth factors and GLUT1, a new marker for hemangiomas of infancy.
  • [MeSH-major] Hemangioma

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  • [Copyright] Clin Pediatr. 2005;44:747-766.
  • (PMID = 16327961.001).
  • [ISSN] 0009-9228
  • [Journal-full-title] Clinical pediatrics
  • [ISO-abbreviation] Clin Pediatr (Phila)
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adrenal Cortex Hormones
  • [Number-of-references] 144
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96. Astner S, González S, Cuevas J, Röwert-Huber J, Sterry W, Stockfleth E, Ulrich M: Preliminary evaluation of benign vascular lesions using in vivo reflectance confocal microscopy. Dermatol Surg; 2010 Jul;36(7):1099-110
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  • [Title] Preliminary evaluation of benign vascular lesions using in vivo reflectance confocal microscopy.
  • BACKGROUND: Reflectance confocal microscopy (RCM) is a novel noninvasive imaging technique for in vivo evaluation of cutaneous lesions at near-histologic resolution.
  • The applicability of RCM for various neoplastic and inflammatory skin diseases has been shown, but a descriptive evaluation of different vascular lesions has not yet been performed.
  • OBJECTIVES: To define specific RCM criteria for congenital and acquired vascular lesions and to determine whether these criteria may assist in their differential diagnosis.
  • MATERIALS AND METHODS: Seven patients with a clinical diagnosis of vascular lesion, including spider angioma, venous lake, cherry angioma, pyogenic granuloma, port wine stain, angiokeratoma, and lymphangioma, participated in this study.
  • Skin sites were systematically analyzed using RCM, and biopsy was obtained for clinically indeterminate lesions.
  • The most relevant criteria included the diameter of the vessels and degree of vascular tortuosity or dilation.
  • CONCLUSION: The findings of this preliminary evaluation indicate that RCM may aid in the noninvasive characterization of inflammatory, proliferative, and ectatic vascular malformations in vivo.
  • [MeSH-major] Granuloma, Pyogenic / pathology. Lymphangioma / pathology. Microscopy, Confocal / methods. Neoplasms, Vascular Tissue / pathology. Port-Wine Stain / pathology. Skin Neoplasms / pathology

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  • (PMID = 20653723.001).
  • [ISSN] 1524-4725
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Controlled Clinical Trial; Journal Article
  • [Publication-country] United States
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97. Rodriguez V, Lee A, Witman PM, Anderson PA: Kasabach-merritt phenomenon: case series and retrospective review of the mayo clinic experience. J Pediatr Hematol Oncol; 2009 Jul;31(7):522-6
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  • Kasabach-Merritt phenomenon (KMP) is a rare thrombocytopenic consumption coagulopathy associated with an enlarging tufted angioma or kaposiform hemangioendothelioma.
  • Nine patients with a diagnosis of KMP were identified through retrospective chart review-6 had "definite KMP" and 3 had "less likely KMP."
  • The hematologic features of KMP and those of chronic coagulopathy seen with other vascular malformations can be similar, which makes KMP difficult to distinguish.
  • [MeSH-major] Disseminated Intravascular Coagulation / complications. Disseminated Intravascular Coagulation / physiopathology. Hemangioendothelioma / complications. Hemangioma / complications. Skin Neoplasms / complications

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  • (PMID = 19564750.001).
  • [ISSN] 1536-3678
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 0 / Antineoplastic Agents
  • [Number-of-references] 10
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98. Abe M, Misago N, Tanaka S, Masuoka J, Tabuchi K: Capillary hemangioma of the central nervous system: a comparative study with lobular capillary hemangioma of the skin. Acta Neuropathol; 2005 Feb;109(2):151-8
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  • [Title] Capillary hemangioma of the central nervous system: a comparative study with lobular capillary hemangioma of the skin.
  • Capillary hemangiomas have rarely been reported to develop in the brain or spinal cord.
  • Here we report the histological and immunohistochemical features of ten cases of central nervous system capillary hemangiomas (CNSCH) and compare these to those of lobular capillary hemangioma (LCH) of the skin.
  • These features were not statistically different from those of LCH of the skin, although the highly cellular area was more prominent and more frequent in cases of CNSCH.
  • Immunohistochemical studies demonstrated no positive staining of endothelial cells within either lesion for erythrocyte-type glucose transporter protein, which is a selective marker for capillary hemangioma of infancy.
  • Vascular endothelial growth factor immunostaining demonstrated positive cells in the solid or immature-appearing areas without vessel lumen formation in both lesions.
  • The MIB-1 index of CNSCH was variable (mean 5.6%) and the apoptotic index of CNSCH was significantly lower than that of LCH of the skin.
  • CNSCH are benign lesions with histological and immunohistochemical features similar to those of LCH of the skin.
  • [MeSH-major] Central Nervous System Neoplasms / pathology. Granuloma, Pyogenic / pathology. Hemangioma, Capillary / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Cell Death / physiology. Child. Endothelium / pathology. Female. Follow-Up Studies. Glucose Transporter Type 1. Humans. Immunohistochemistry / methods. In Situ Nick-End Labeling / methods. Ki-67 Antigen / metabolism. Male. Middle Aged. Monosaccharide Transport Proteins / metabolism. Staining and Labeling / methods. Vascular Endothelial Growth Factor A / metabolism

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  • (PMID = 15365728.001).
  • [ISSN] 0001-6322
  • [Journal-full-title] Acta neuropathologica
  • [ISO-abbreviation] Acta Neuropathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Glucose Transporter Type 1; 0 / Ki-67 Antigen; 0 / Monosaccharide Transport Proteins; 0 / SLC2A1 protein, human; 0 / Vascular Endothelial Growth Factor A
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99. Nakashima T, Jinnin M, Etoh T, Fukushima S, Masuguchi S, Maruo K, Inoue Y, Ishihara T, Ihn H: Down-regulation of mir-424 contributes to the abnormal angiogenesis via MEK1 and cyclin E1 in senile hemangioma: its implications to therapy. PLoS One; 2010;5(12):e14334
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  • [Title] Down-regulation of mir-424 contributes to the abnormal angiogenesis via MEK1 and cyclin E1 in senile hemangioma: its implications to therapy.
  • BACKGROUND: Senile hemangioma, so-called cherry angioma, is known as the most common vascular anomalies specifically seen in the aged skin.
  • METHODOLOGY/PRINCIPAL FINDINGS: In this study, we found that senile hemangioma consisted of clusters of proliferated small vascular channels in upper dermis, indicating that this tumor is categorized as a vascular tumor.
  • We then investigated the mechanism of endothelial proliferation in senile hemangioma, focusing on microRNA (miRNA).
  • miRNA PCR array analysis revealed the mir-424 level in senile hemangioma was lower than in other vascular anomalies.
  • Protein expression of MEK1 and cyclin E1, the predicted target genes of mir-424, was increased in senile hemangioma compared to normal skin or other anomalies, but their mRNA levels were not.
  • CONCLUSIONS/SIGNIFICANCE: Taken together, decreased mir-424 expression and increased levels of MEK1 or cyclin E1 in senile hemangioma may cause abnormal cell proliferation in the tumor.
  • Senile hemangioma may be the good model for cutaneous angiogenesis.
  • Investigation of senile hemangioma and the regulatory mechanisms of angiogenesis by miRNA in the aged skin may lead to new treatments using miRNA by the transfection into senile hemangioma.
  • [MeSH-major] Cyclin E / biosynthesis. Gene Expression Regulation. Hemangioma / enzymology. MAP Kinase Kinase 1 / biosynthesis. MicroRNAs / biosynthesis. Oncogene Proteins / biosynthesis

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  • (PMID = 21179471.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CCNE1 protein, human; 0 / Cyclin E; 0 / MIRN424 microrna, human; 0 / MicroRNAs; 0 / Oncogene Proteins; 0 / RNA, Messenger; EC 2.7.12.2 / MAP Kinase Kinase 1
  • [Other-IDs] NLM/ PMC3001869
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100. Hess CP, Fullerton HJ, Metry DW, Drolet BA, Siegel DH, Auguste KI, Gupta N, Haggstrom AN, Dowd CF, Frieden IJ, Barkovich AJ: Cervical and intracranial arterial anomalies in 70 patients with PHACE syndrome. AJNR Am J Neuroradiol; 2010 Nov;31(10):1980-6
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  • BACKGROUND AND PURPOSE: Cerebral and cervical arterial abnormalities are the most common non-cutaneous anomaly in PHACE syndrome, but the location and type of arterial lesions that occur have not been systematically assessed in a large cohort.
  • Our aim was to characterize the phenotypic spectrum of arteriopathy, assess the frequency with which different arteries are involved, and evaluate spatial relationships between arteriopathy, brain structural lesions, and hemangiomas in PHACE syndrome.
  • Univariate logistic regression analyses were performed to test for associations between arteriopathy location, hemangiomas, and brain abnormalities.
  • Hemangiomas were ipsilateral to arteriopathy in all but 1 case.
  • The frontotemporal and/or mandibular facial segments were involved in 97% of cases, but no other specific associations between arteriopathy location and hemangioma sites were detected.
  • CONCLUSIONS: The arteriopathy of PHACE syndrome commonly involves the ICA and its embryonic branches, ipsilateral to the cutaneous hemangioma, with dysgenesis and abnormal arterial course the most commonly noted abnormalities.
  • [MeSH-major] Carotid Artery, Internal / abnormalities. Hemangioma / pathology. Magnetic Resonance Angiography. Vascular Neoplasms / pathology

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  • (PMID = 20705698.001).
  • [ISSN] 1936-959X
  • [Journal-full-title] AJNR. American journal of neuroradiology
  • [ISO-abbreviation] AJNR Am J Neuroradiol
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / UL1 RR024140 01
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] PHACE association
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