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1. Fiscon V, Portale G, Isoardi R, Frigo F, Migliorini G: Spontaneous rupture of giant gastric GIST presenting as hemoperitoneum and mimicking cavernous liver angioma. Tumori; 2009 Mar-Apr;95(2):233-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spontaneous rupture of giant gastric GIST presenting as hemoperitoneum and mimicking cavernous liver angioma.
  • A CT scan suggested rupture of a cavernous angioma of the liver and the patient was brought to the operating room for an explorative laparoscopy, which revealed hemoperitoneum from a ruptured giant gastric GIST.
  • [MeSH-major] Gastrointestinal Stromal Tumors / complications. Gastrointestinal Stromal Tumors / diagnosis. Hemangioma, Cavernous / diagnosis. Hemoperitoneum / etiology. Liver Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Immunohistochemistry. Laparoscopy. Laparotomy. Male. Necrosis. Rupture, Spontaneous / complications. Rupture, Spontaneous / diagnosis. Tomography, X-Ray Computed

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  • (PMID = 19579871.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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2. Xuan SY, Li N, Qiang X, Zhou RR, Shi YX, Jiang WJ: Helicobacter infection in hepatocellular carcinoma tissue. World J Gastroenterol; 2006 Apr 21;12(15):2335-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Liver samples from 28 patients with hepatocellular carcinoma (HCC) diagnosed by histopathology were studied.
  • Twenty-two patients with other liver diseases (5 with liver trauma, 7 with cavernous liver hemangioma, 6 with liver cyst and 4 with hepatolithiasis), 25 patients with gastric cancer, 15 with colonic cancer and 15 with myoma of uterus served as controls.
  • CONCLUSION: Helicobacter infection exists in liver tissues of HCC patients.
  • [MeSH-major] Carcinoma, Hepatocellular / complications. Helicobacter Infections / complications. Liver Neoplasms / complications

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  • (PMID = 16688821.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / DNA, Bacterial; 0 / RNA, Bacterial; 0 / RNA, Ribosomal, 16S
  • [Other-IDs] NLM/ PMC4088066
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3. Koszka AJ, Ferreira FG, de Aquino CG, Ribeiro MA, Gallo AS, Aranzana EM, Szutan LA: Resection of a rapid-growing 40-cm giant liver hemangioma. World J Hepatol; 2010 Jul 27;2(7):292-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Resection of a rapid-growing 40-cm giant liver hemangioma.
  • Hemangiomas are the most frequent benign tumors of the liver.
  • Most hemangiomas are asymptomatic and therefore largely diagnosed only in routine screening tests.
  • Resection of liver hemangioma is indicated in cases of great dimension tumors causing symptoms such as pain, nausea or bloating caused by compression of adjacent organs.
  • We report a case of a rare giant hemangioma with rapid growth in short time: a 50 year old female reported to our institution with a 40 cm giant liver hemangioma and then underwent a left hepatectomy.

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  • (PMID = 21161011.001).
  • [ISSN] 1948-5182
  • [Journal-full-title] World journal of hepatology
  • [ISO-abbreviation] World J Hepatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2999292
  • [Keywords] NOTNLM ; Giant liver Hemangioma / Liver benign neoplasms / Liver surgery
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4. Rangheard AS, Menu Y, Bléry M: [Angioma of the liver on MRI]. Presse Med; 2008 Feb;37(2 Pt 2):360-1
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Angioma of the liver on MRI].
  • [Transliterated title] Angiome du foie--aspect en IRM.
  • [MeSH-major] Hemangioma / diagnosis. Liver Neoplasms / diagnosis. Magnetic Resonance Imaging

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  • (PMID = 17616328.001).
  • [ISSN] 2213-0276
  • [Journal-full-title] Presse medicale (Paris, France : 1983)
  • [ISO-abbreviation] Presse Med
  • [Language] fre
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Contrast Media; K2I13DR72L / Gadolinium DTPA
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5. Demircan O, Demiryurek H, Yagmur O: Surgical approach to symptomatic giant cavernous hemangioma of the liver. Hepatogastroenterology; 2005 Jan-Feb;52(61):183-6
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  • [Title] Surgical approach to symptomatic giant cavernous hemangioma of the liver.
  • BACKGROUND/AIMS: Surgical treatment of giant cavernous hemangioma of the liver is still controversial.
  • METHODOLOGY: Fifteen patients with symptomatic giant cavernous hemangioma of the liver were treated by enucleation or liver resection.
  • RESULTS: The surgical indications were abdominal pain in 11 patients, uncertain diagnosis in 3 patients and tumor enlargement in one patient.
  • CONCLUSIONS: Abdominal pain, uncertain diagnosis and enlargement are major surgical indications of symptomatic giant cavernous hemangiomas.
  • [MeSH-major] Hemangioma, Cavernous / surgery. Liver Neoplasms / surgery

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  • (PMID = 15783025.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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6. Lee VT, Magnaye M, Tan HW, Thng CH, Ooi LL: Sclerosing haemangioma mimicking hepatocellular carcinoma. Singapore Med J; 2005 Mar;46(3):140-3
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  • [Title] Sclerosing haemangioma mimicking hepatocellular carcinoma.
  • Sclerosing haemangioma is a rare variant of hepatic haemangioma.
  • The radiological features on computed tomography and magnetic resonance imaging may not be typical for haemangioma and can be confused with hepatocellular carcinoma.
  • We report sclerosing haemangioma occurring in a 65-year-old woman where the radiological features raise the possibility of hepatocellular carcinoma.
  • [MeSH-major] Carcinoma, Hepatocellular / diagnosis. Hemangioma / diagnosis. Liver / pathology. Liver Neoplasms / diagnosis. Sclerosis / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Tomography, X-Ray Computed

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  • (PMID = 15735880.001).
  • [ISSN] 0037-5675
  • [Journal-full-title] Singapore medical journal
  • [ISO-abbreviation] Singapore Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
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7. Mahajan D, Miller C, Hirose K, McCullough A, Yerian L: Incidental reduction in the size of liver hemangioma following use of VEGF inhibitor bevacizumab. J Hepatol; 2008 Nov;49(5):867-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Incidental reduction in the size of liver hemangioma following use of VEGF inhibitor bevacizumab.
  • BACKGROUND/AIMS: Hepatic cavernous hemangioma is the second most common liver tumor after metastases.
  • High VEGF expression leads to increased angiogenic activity in cavernous hemangioma endothelial cells.
  • METHODS: We report a patient with invasive colorectal adenocarcinoma and suspected liver metastasis on radiological examination, who showed a significant decrease in the size of his liver lesions after bevacizumab treatment.
  • Histology of the liver lesions revealed hemangioma with a strong staining for VEGF and anti-VEGFr2 antibody in the hemangioma endothelial cells.
  • To date, surgical resection provides the only consistently effective method for treatment of hepatic hemangioma.
  • CONCLUSIONS: This is the first documented case of hepatic hemangioma responsive to antiangiogenic therapy, suggesting a possible use for these agents in treating symptomatic patients without surgery.
  • VEGF-signaling blockade including bevacizumab use poses a potential new treatment modality for vascular neoplasms in the liver and other sites.
  • [MeSH-major] Antibodies, Monoclonal / therapeutic use. Hemangioma, Cavernous / therapy. Liver Neoplasms / therapy. Vascular Endothelial Growth Factor A / antagonists & inhibitors

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  • (PMID = 18814928.001).
  • [ISSN] 0168-8278
  • [Journal-full-title] Journal of hepatology
  • [ISO-abbreviation] J. Hepatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A; 2S9ZZM9Q9V / Bevacizumab
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8. El-Hashemite N, Walker V, Kwiatkowski DJ: Estrogen enhances whereas tamoxifen retards development of Tsc mouse liver hemangioma: a tumor related to renal angiomyolipoma and pulmonary lymphangioleiomyomatosis. Cancer Res; 2005 Mar 15;65(6):2474-81
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  • [Title] Estrogen enhances whereas tamoxifen retards development of Tsc mouse liver hemangioma: a tumor related to renal angiomyolipoma and pulmonary lymphangioleiomyomatosis.
  • Tsc1+/- and Tsc2+/- mice frequently develop liver hemangioma.
  • We found that the Tsc mouse liver hemangioma are composed predominantly of endothelial cells but with a smooth muscle component, and express HMB45 antigen, estrogen receptor, and progesterone receptor, similar to lymphangioleiomyomatosis and angiomyolipoma.
  • Estrogen treatment significantly accelerated the development of liver hemangioma in Tsc1+/- female mice, with 91% having liver hemangioma and 55% having severe lesions by 7 months of age.
  • Similarly, an increased frequency and severity of liver hemangiomas was seen in Tsc1+/- males treated with estrogen.
  • In contrast, tamoxifen treatment for 9 months significantly reduced the frequency and severity of hemangiomas in Tsc1+/- female mice.
  • [MeSH-major] Estradiol / pharmacology. Hemangioma / pathology. Liver Neoplasms / pathology. Repressor Proteins / genetics. Tamoxifen / pharmacology. Tumor Suppressor Proteins / genetics

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  • (PMID = 15781664.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Grant] United States / NINDS NIH HHS / NS / NS24279; United States / NINDS NIH HHS / NS / NS31535
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Repressor Proteins; 0 / Tumor Suppressor Proteins; 0 / Vascular Endothelial Growth Factor A; 0 / tuberous sclerosis complex 1 protein; 094ZI81Y45 / Tamoxifen; 4JG2LF96VF / tuberous sclerosis complex 2 protein; 4TI98Z838E / Estradiol
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9. Masui T, Katayama M, Nakagawara M, Shimizu S, Kojima K: Exophytic giant cavernous hemangioma of the liver with growing tendency. Radiat Med; 2005 Mar;23(2):121-4
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  • [Title] Exophytic giant cavernous hemangioma of the liver with growing tendency.
  • Hepatic hemangioma is a common benign tumor, but its exophytic and expansile forms may be atypical.
  • We report a case of exophytic hemangioma of the liver with a growing tendency, demonstrated using magnetic resonance imaging (MRI) and computed tomography (CT) combined with angiography.
  • [MeSH-major] Hemangioma, Cavernous / diagnosis. Liver Neoplasms / diagnosis

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  • (PMID = 15827530.001).
  • [ISSN] 0288-2043
  • [Journal-full-title] Radiation medicine
  • [ISO-abbreviation] Radiat Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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10. Miliaras D, Conroy J, Pervana S, Meditskou S, McQuaid D, Nowak N: Karyotypic changes detected by comparative genomic hybridization in a stillborn infant with chorioangioma and liver hemangioma. Birth Defects Res A Clin Mol Teratol; 2007 Mar;79(3):236-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Karyotypic changes detected by comparative genomic hybridization in a stillborn infant with chorioangioma and liver hemangioma.
  • BACKGROUND: Placental hemangioma (chorioangioma) and congenital hemangioma are relatively common tumors, which on rare occasions may occur together.
  • CASE: Herein we describe a rare case of a stillborn infant with chorioangioma, placental mesenchymal dysplasia, and liver cavernous hemangioma.
  • The chromosomal abnormalities that we found were deletions at 2q13 and 7p21.1 and were common to both placental and liver lesions.
  • CONCLUSIONS: None of the identified chromosomal aberrations have been previously associated with chorioangiomas or hemangiomas.
  • Important genes that lie in these DNA regions may be implicated in the pathogenesis of congenital hemangiomas and mesenchymal dysplasia.
  • [MeSH-major] Chromosome Aberrations. Hemangioma / genetics. Hemangioma, Cavernous / genetics. Liver Neoplasms / genetics. Placenta Diseases / genetics. Stillbirth / genetics

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  • (PMID = 17203486.001).
  • [ISSN] 1542-0752
  • [Journal-full-title] Birth defects research. Part A, Clinical and molecular teratology
  • [ISO-abbreviation] Birth Defects Res. Part A Clin. Mol. Teratol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA016056-30
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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11. Zhang WJ, Wu LQ, Liu HL, Ye LY, Xin YL, Grau GE, Lou JN: Abnormal blood vessels formed by human liver cavernous hemangioma endothelial cells in nude mice are suitable for drug evaluation. Microvasc Res; 2009 Dec;78(3):379-85
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Abnormal blood vessels formed by human liver cavernous hemangioma endothelial cells in nude mice are suitable for drug evaluation.
  • Cavernous hemangioma is vascular malformation with developmental aberrations.
  • It was assumed that the abnormality of endothelial cells contributed greatly to the occurrence of cavernous hemangioma.
  • In our previous study, we have found distinct characteristics of endothelial cells derived from human liver cavernous hemangioma (HCHEC).
  • HCHEC was isolated from a human liver cavernous hemangioma specimen, and the HCHEC generated a red hemangioma-like mass 7 days after subcutaneously co-inoculating HCHEC and human liver cancer cells (Bel-7402) in nude mice.
  • And the pathological features of vascular vessels formed by HCHEC were very similar to clinical cavernous hemangioma.
  • Moreover, podophyllotoxin was also effective for destroying the abnormal vascular vessels in the hemangioma-like mass in nude mice.
  • In summary, the HCHEC can form abnormal blood vessels in nude mice, and we can evaluate drugs for cavernous hemangioma by using HCHEC in vitro and in vivo.
  • [MeSH-major] Antineoplastic Agents, Phytogenic / pharmacology. Blood Vessels / pathology. Hemangioma, Cavernous / pathology. Liver Neoplasms / pathology. Podophyllotoxin / pharmacology

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  • (PMID = 19729028.001).
  • [ISSN] 1095-9319
  • [Journal-full-title] Microvascular research
  • [ISO-abbreviation] Microvasc. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Antineoplastic Agents, Phytogenic; 147336-22-9 / Green Fluorescent Proteins; L36H50F353 / Podophyllotoxin
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12. Huang TR, Yu JH, Li JL, Zhang ZQ, Deng W, Zhang CY, Zhao SF: [A cross-sectional study on liver diseases in the rural residents in southern Guangxi, China]. Zhonghua Yu Fang Yi Xue Za Zhi; 2007 Jun;41 Suppl:123-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A cross-sectional study on liver diseases in the rural residents in southern Guangxi, China].
  • OBJECTIVE: To study the epidemiological characteristics of liver diseases in a rural population in Southern Guangxi, China.
  • Liver morphological changes were measured with ultrasonography of type B.
  • The prevalence rates of viral hepatitis B, cirrhosis, primary liver cancer, clonorchiasis, fatty liver disease, alcoholic liver disease were 1.1% (173/15,701), 0.4% (63/15,701), 299.3 per 100,000 (47/15,701), 6.6% (1036/15,701), 4.8% (754/15,701) and 0.3% (47/15,701), respectively.
  • The positive rates of HBsAg and the prevalence rates of viral hepatitis B, cirrhosis, primary liver cancer, clonorchiasis, fatty liver disease in male were significantly higher as compared with those in female (5.98 < or = chi(2) < or = 394.78, P < 0.01).
  • No difference was observed in the prevalence rates of liver cavernous hemangioma and hepatic cysts between male and female.
  • But the prevalence rates of cirrhosis, primary liver cancer, fatty liver disease, alcoholic liver disease, liver cavernous hemangioma, hepatic cysts and intrahepatic bile duct stones were increased with age.
  • CONCLUSION: The rural areas in the southern Guangxi are high prevalence regions of liver illness, and the male resident are even at high risk.
  • [MeSH-major] Liver Diseases / epidemiology
  • [MeSH-minor] Adult. China / epidemiology. Cross-Sectional Studies. Fatty Liver / epidemiology. Female. Hepatitis B / epidemiology. Humans. Liver Cirrhosis / epidemiology. Liver Neoplasms / epidemiology. Male. Middle Aged. Prevalence. Rural Population

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  • (PMID = 17767876.001).
  • [ISSN] 0253-9624
  • [Journal-full-title] Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]
  • [ISO-abbreviation] Zhonghua Yu Fang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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13. Zincirkeser S, Celen ZY, Yilmaz M, Topalhan F, Sahin E: A false negative by planar scintigraphy liver hemangioma, diagnosed by technetium-99m-red blood cells and technetium-99m-sulfur colloid single photon emission tomography scan. Hell J Nucl Med; 2006 May-Aug;9(2):109-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A false negative by planar scintigraphy liver hemangioma, diagnosed by technetium-99m-red blood cells and technetium-99m-sulfur colloid single photon emission tomography scan.
  • Ultrasonography showed a 4.7 cm solid hepatic mass on the right lateral side of the right lobe of the liver.
  • The patient was then sent to the Nuclear Medicine Department of Gaziantep University for liver scan.
  • After injecting autologous red blood cells labeled with 740 MBq of technetium-99m ((99m)Tc-RBC), early and delayed anterior planar images of the liver showed no significant findings because of the right kidney shine through the liver.
  • Two days later, after injecting again 740 MBq of (99m)Tc-RBC, we performed a single photon emission tomography (SPET) scan but still this scan was nondiagnostic even in the delayed images of the liver.
  • Three days later, after the iv injection of 185 MBq of technetium-99m-sulphur colloid ((99m)Tc-SC), we observed in the delayed SPET images of the liver, a mismatch defect with decreased focal uptake of (99m)Tc-SC at 60 min while the uptake of (99m)Tc-RBC at the same area was normal or slightly increased.
  • A cavernous hemangioma was found, confirmed by histology.
  • In conclusion, the mismatch of the SPET delayed images between the (99m)Tc-RBC and the (99m)Tc-SC scans indicated that this procedure was effective for the diagnosis of liver cavernous hemangioma located in this unusual position.
  • [MeSH-major] Erythrocytes / radionuclide imaging. Hemangioma / radionuclide imaging. Liver Neoplasms / radionuclide imaging. Technetium. Technetium Tc 99m Sulfur Colloid. Tomography, Emission-Computed, Single-Photon / methods

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  • [CommentIn] Hell J Nucl Med. 2009 May-Aug;12(2):177-8 [19675879.001]
  • [CommentIn] Hell J Nucl Med. 2006 Sep-Dec;9(3):187 [17160164.001]
  • (PMID = 16894416.001).
  • [ISSN] 1790-5427
  • [Journal-full-title] Hellenic journal of nuclear medicine
  • [ISO-abbreviation] Hell J Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 556Q0P6PB1 / Technetium Tc 99m Sulfur Colloid; 7440-26-8 / Technetium
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14. Matsushita M, Takehara Y, Nasu H, Hirai Y, Yamashita S, Souda K, Kobayashi Y, Miura K: Atypically enhanced cavernous hemangiomas of the liver: centrifugal enhancement does not preclude the diagnosis of hepatic hemangioma. J Gastroenterol; 2006 Dec;41(12):1227-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atypically enhanced cavernous hemangiomas of the liver: centrifugal enhancement does not preclude the diagnosis of hepatic hemangioma.
  • The imaging features of an atypically enhanced hepatic hemangioma have not been well described in the literature, and the presence of such atypia may sometimes cause clinical problems in the differential diagnosis.
  • Herein, we report a case of hepatic hemangioma demonstrating a previously unreported atypical enhancement pattern.
  • On dynamic computed tomography during hepatic arteriography, a centrifugal enhancement pattern and subsequent peritumoral ring-shaped enhancement mimicking corona enhancement were found in cavernous hemangiomas of the liver in a 68-year-old Japanese man.
  • Histopathological diagnosis of cavernous hemangioma of the liver was made on a biopsy specimen.
  • Considering the importance of differentiating benign hepatic tumor from various forms of malignancy, radiologists and hepatologists should be aware of rare enhancement patterns sometimes seen in hepatic hemangioma.
  • Establishing knowledge of the entire spectrum of atypical hepatic hemangioma may benefit the rational approach to future cases.
  • [MeSH-major] Hemangioma, Cavernous / diagnosis. Image Enhancement. Liver Neoplasms / diagnosis. Tomography, X-Ray Computed

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  • (PMID = 17287903.001).
  • [ISSN] 0944-1174
  • [Journal-full-title] Journal of gastroenterology
  • [ISO-abbreviation] J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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15. Shimada K, Nakamoto Y, Isoda H, Saito H, Arizono S, Shibata T, Togashi K: FDG PET for giant cavernous hemangioma: important clue to differentiate from a malignant vascular tumor in the liver. Clin Nucl Med; 2010 Dec;35(12):924-6
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  • [Title] FDG PET for giant cavernous hemangioma: important clue to differentiate from a malignant vascular tumor in the liver.
  • Giant cavernous hemangioma of the liver sometimes has a very inhomogeneous appearance with intratumoral degeneration on computed tomography or magnetic resonance imaging, and may mimic a malignant hepatic tumor, including angiosarcoma.
  • There are many reports about F-18 fluorodeoxyglucose (FDG) uptake of angiosarcoma; however, knowledge regarding positron emission tomography findings with FDG for giant hepatic cavernous hemangioma is still limited.
  • We herein present 2 cases of giant hepatic cavernous hemangioma in which low FDG uptake was considered helpful to differentiate from malignant hepatic tumor.
  • [MeSH-major] Fluorodeoxyglucose F18. Hemangioma, Cavernous / radionuclide imaging. Liver Neoplasms / radionuclide imaging. Positron-Emission Tomography
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Middle Aged

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  • (PMID = 21206221.001).
  • [ISSN] 1536-0229
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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16. van Gorcum M, van Buuren HR, Hussain SM, Zondervan PE, IJzermans JN, de Man RA: [Fever as a sign of inflammatory syndrome in a female patient with hepatic haemangioma]. Ned Tijdschr Geneeskd; 2005 May 28;149(22):1227-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Fever as a sign of inflammatory syndrome in a female patient with hepatic haemangioma].
  • [Transliterated title] Koorts als uiting van inflammatoir syndroom bij een patiënte met een leverhemangioom.
  • Diagnostic imaging revealed a hepatic haemangioma with a diameter of 20 cm.
  • Because such giant haemangiomas of the liver can lead to inflammatory syndrome, the tumour was surgically removed.
  • Pathological analysis confirmed the clinical diagnosis and evidence of extensive thrombosis and other vascular defects was found.
  • In patients with a giant haemangioma in the liver who present with an inflammatory syndrome, the haemangioma should be considered as the causal factor.
  • [MeSH-major] Hemangioma / diagnosis. Liver Neoplasms / diagnosis. Systemic Inflammatory Response Syndrome / diagnosis
  • [MeSH-minor] Abdominal Pain / etiology. Adult. Diagnosis, Differential. Female. Fever / etiology. Humans. Treatment Outcome. Weight Loss

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  • (PMID = 15952499.001).
  • [ISSN] 0028-2162
  • [Journal-full-title] Nederlands tijdschrift voor geneeskunde
  • [ISO-abbreviation] Ned Tijdschr Geneeskd
  • [Language] dut
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Netherlands
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17. Katada Y, Yasumoto M, Ishii C, Tanaka H, Nakamoto K, Ohashi I, Nozaki M: Differentiation between hepatic haemangiomas and cysts with an inversion recovery single-shot turbo spin-echo (SSTSE) sequence using the TI nulling value of hepatic haemangioma with sensitivity encoding. Eur Radiol; 2010 Sep;20(9):2241-7
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  • [Title] Differentiation between hepatic haemangiomas and cysts with an inversion recovery single-shot turbo spin-echo (SSTSE) sequence using the TI nulling value of hepatic haemangioma with sensitivity encoding.
  • OBJECTIVE: To evaluate the additional value of inversion recovery (IR) single-shot turbo spin-echo (SSTSE) imaging with sensitivity encoding (SENSE) using the inversion time (TI) value of hepatic haemangioma as a supplement to conventional T2-weighted turbo spin-echo (TSE) imaging for the discrimination of hepatic haemangiomas and cysts.
  • METHODS: A total of 134 lesions (77 hepatic haemangiomas, 57 hepatic cysts) in 59 patients were evaluated.
  • CONCLUSION: The introduction of IR-SSTSE with SENSE sequences significantly improves the diagnostic accuracy of the differentiation of hepatic haemangioma and cysts while increasing the time required for routine abdominal imaging by only 20 s.
  • [MeSH-major] Algorithms. Cysts / diagnosis. Hemangioma / diagnosis. Image Enhancement / methods. Image Interpretation, Computer-Assisted / methods. Liver Diseases / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Reproducibility of Results. Sensitivity and Specificity. Signal Processing, Computer-Assisted. Spin Labels

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  • (PMID = 20309552.001).
  • [ISSN] 1432-1084
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Spin Labels
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18. Ito K, Taira K, Arii S: Intrahepatic bile duct dilatation with a liver cyst and hemangioma: report of a case. Surg Today; 2009;39(3):256-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intrahepatic bile duct dilatation with a liver cyst and hemangioma: report of a case.
  • We report a case of intrahepatic bile duct dilatation with a liver cyst and hemangioma.
  • A 58-year-old woman was referred for investigation of a cystic lesion and peripheral intrahepatic bile duct dilatation in the left lateral segment of the liver.
  • Microscopically, the cyst was lined with a single layer of flattened epithelial cells and a spongy tumor was diagnosed as cavernous hemangioma, which compressed the bile duct.
  • The histopathological diagnosis was biliary stenosis associated with cavernous hemangioma of the liver.
  • Invasive surgery may be avoided by awareness of this unusual benign pathology.
  • [MeSH-major] Bile Ducts, Intrahepatic / pathology. Cysts / pathology. Hemangioma / pathology. Liver Diseases / pathology. Liver Neoplasms / pathology

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  • (PMID = 19280288.001).
  • [ISSN] 1436-2813
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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19. Limawararut V, Davis G, Crompton J, Leibovitch I, Selva D: Recurrent multiple cavernous hemangiomas of the orbit in association with systemic tumors. Am J Ophthalmol; 2006 May;141(5):943-5
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  • [Title] Recurrent multiple cavernous hemangiomas of the orbit in association with systemic tumors.
  • PURPOSE: To report the clinical findings and management of multiple, recurrent cavernous hemangiomas of the orbit in a patient with concurrent liver involvement.
  • RESULTS: A 35-year-old woman with blurry vision and proptosis was found to have multiple cavernous hemangiomas of the orbit.
  • Fifteen years later, the patient had recurrent, multiple cavernous hemangiomas in the same orbit.
  • Further investigations for vague back pain revealed a presumed cavernous hemangioma in the liver and a presumed schwannoma arising from the neural foramen of the spine at the level of T2 through T4.
  • CONCLUSION: Multiple cavernous hemangiomas may recur after complete excision and may exist with concurrent systemic tumors.
  • [MeSH-major] Hemangioma, Cavernous / pathology. Liver Neoplasms / pathology. Neoplasm Recurrence, Local / pathology. Neoplasms, Multiple Primary / pathology. Neurilemmoma / pathology. Orbital Neoplasms / pathology. Pleural Neoplasms / pathology

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  • (PMID = 16678512.001).
  • [ISSN] 0002-9394
  • [Journal-full-title] American journal of ophthalmology
  • [ISO-abbreviation] Am. J. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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20. Romero FR, Wagner AA, Bagga HS, Muntener M, Brito FA, Kavoussi LR: Laparoscopic treatment of simultaneous tumors in the liver and kidney. Urol Int; 2007;79(2):142-4
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  • [Title] Laparoscopic treatment of simultaneous tumors in the liver and kidney.
  • BACKGROUND/AIMS: To report our experience with laparoscopic treatment of liver tumors during right-sided transperitoneal laparoscopic nephrectomy.
  • METHODS: Two patients undergoing transperitoneal laparoscopic radical nephrectomy on the right side each had a concomitant tumor in the right lobe of the liver.
  • The second had a known asymptomatic giant hemangioma of the liver.
  • The first patient had bilateral papillary renal cell carcinoma and concomitant fibroadipose tissue within the liver.
  • The second patient presented with clear cell carcinoma of the right kidney and a cavernous hemangioma of the liver.
  • CONCLUSIONS: When indicated, simultaneous right-sided kidney and liver tumors may be treated by a combined laparoscopic transperitoneal approach.
  • [MeSH-major] Carcinoma, Renal Cell / surgery. Hemangioma, Cavernous / surgery. Kidney Neoplasms / surgery. Liver Neoplasms / surgery. Neoplasms, Multiple Primary / surgery

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  • [Copyright] 2007 S. Karger AG, Basel
  • (PMID = 17851284.001).
  • [ISSN] 1423-0399
  • [Journal-full-title] Urologia internationalis
  • [ISO-abbreviation] Urol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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21. Patriti A, Graziosi L, Sanna A, Gullà N, Donini A: Laparoscopic treatment of liver hemangioma. Surg Laparosc Endosc Percutan Tech; 2005 Dec;15(6):359-62
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  • [Title] Laparoscopic treatment of liver hemangioma.
  • Cavernous hemangioma is the most common benign liver tumor.
  • When it becomes symptomatic, enucleation is considered the treatment of choice because of its lower morbidity compared with liver resection.
  • Therefore, although there have been many series of laparoscopic liver resection, only a few cases of laparoscopic enucleation of liver hemangiomas have been reported.
  • We report the case of a 36-year-old woman with a symptomatic 4-cm liver hemangioma of the left lobe who underwent laparoscopic enucleation, with complete relief of the symptoms at the 3-month follow-up.
  • Neither liver mobilization nor ligament division was necessary.
  • Laparoscopic enucleation is easy to perform in suitable lesions, and its advantage with respect to liver resection is the preservation of healthy parenchyma and liver ligaments.
  • [MeSH-major] Hemangioma / surgery. Hepatectomy / methods. Laparoscopy. Liver Neoplasms / surgery

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  • (PMID = 16340570.001).
  • [ISSN] 1530-4515
  • [Journal-full-title] Surgical laparoscopy, endoscopy & percutaneous techniques
  • [ISO-abbreviation] Surg Laparosc Endosc Percutan Tech
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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22. Muthamilselvan S, Vinoth PN, Vilvanathan V, Ninan B, Amboiram P, Sai V, Anand V, Scott JX: Hepatic haemangioma of infancy: role of propranolol. Ann Trop Paediatr; 2010;30(4):335-8
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  • [Title] Hepatic haemangioma of infancy: role of propranolol.
  • A newborn girl with a haemangioma of the liver failed to respond to cortico-steroid therapy.
  • Ultrasonic evidence of the haemangioma disappeared after 2 months of treatment with propranolol.
  • [MeSH-major] Adrenergic beta-Antagonists / therapeutic use. Hemangioma / drug therapy. Infant, Premature, Diseases / drug therapy. Liver Neoplasms / drug therapy. Propranolol / therapeutic use

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  • (PMID = 21118629.001).
  • [ISSN] 1465-3281
  • [Journal-full-title] Annals of tropical paediatrics
  • [ISO-abbreviation] Ann Trop Paediatr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Adrenergic beta-Antagonists; 9Y8NXQ24VQ / Propranolol
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23. Pudil J, Martínek J, Belsan T, Ryska M: [Atypically localised hepatic haemangioma as a cause of dyspeptic syndrome]. Rozhl Chir; 2006 Jul;85(7):354-6
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  • [Title] [Atypically localised hepatic haemangioma as a cause of dyspeptic syndrome].
  • [Transliterated title] Atypicky lokalizovaný hemangiom jater jako prícina dyspeptického syndromu.
  • INTRODUCTION: Haemangioma is a benign mesenchymal tumor growing from the endothehum of blood vessels.
  • Most hepatic haemangiomas are asymptomatic while symptomatic haemangioma are usually manifested by non-specific pain dyspeptic syndrome, quite rarely also by hemorrhage, or icterus Symptomatic haemangiomas or large haemangiomas with fast growth, are indicated for surgical treatment.
  • USG, CT, MR, CT angiography and EUS have all shown two lesiones (haemangioma of the left hepatic lobe, a tumor in the left subphrenic area of uncertain origin).
  • We proposed an operational solution, and, surprisingly, the finding was a single haemangioma (2 parts-- intra- and extraparenchymatous--connected by a vascular bridge).
  • DISCUSSION: In the diagnosis of haemangioma, MR is a method of choice with high specificity and sensitivity.
  • Why did not it yield the correct diagnosis?
  • The structure, the signal and the type of postcontrast enhancement of the second lesion corresponded to a haemangioma, but the extraparenchymatous location and also the considerable remoteness from the liver invalidated this possibility before operation.
  • Regarding to the differential diagnostics of the lesiones in the subphrenic area, which according to the imaging techniques are not related to the hepatic parenchyma, it is advisable to consider the possibility of the incidence of pedunculated hepatic haemangioma.
  • [MeSH-major] Dyspepsia / etiology. Hemangioma, Cavernous / complications. Liver Neoplasms / complications

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  • (PMID = 17044281.001).
  • [ISSN] 0035-9351
  • [Journal-full-title] Rozhledy v chirurgii : měsíčník Československé chirurgické společnosti
  • [ISO-abbreviation] Rozhl Chir
  • [Language] cze
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Czech Republic
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24. Borse R, Mahapatra GN, Meht R, Plumber S, Dhuri S, Ali S: Scintigraphic finding of a silent hepatic haemangioma. J Assoc Physicians India; 2010 Oct;58:637-40
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  • [Title] Scintigraphic finding of a silent hepatic haemangioma.
  • Hepatic haemangioma is the most common benign tumour of liver.
  • Tc 99m RBC blood pool imaging is highly specific diagnostic modality of choice for hepatic haemangioma as its hypervascular nature may create equivocal result on CT or MRI.
  • Therefore all patients suspected of having hepatic haemangioma should undergo Tc 99m blood pool imaging.
  • [MeSH-major] Erythrocytes / radionuclide imaging. Hemangioma / radionuclide imaging. Liver Neoplasms / radionuclide imaging

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  • (PMID = 21510118.001).
  • [ISSN] 0004-5772
  • [Journal-full-title] The Journal of the Association of Physicians of India
  • [ISO-abbreviation] J Assoc Physicians India
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 7440-26-8 / Technetium
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25. Vokaer B, Kothonidis K, Delatte P, De Cooman S, Pector JC, Liberale G: Should ruptured liver haemangioma be treated by surgery or by conservative means? A case report. Acta Chir Belg; 2008 Nov-Dec;108(6):761-4
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  • [Title] Should ruptured liver haemangioma be treated by surgery or by conservative means? A case report.
  • Spontaneous rupture of a liver haemangioma is a rare but life-threatening acute clinical situation following haemorrhage within the liver, the subcapsular space and the peritoneal cavity in cases of capsular rupture.
  • Rupture of a liver haemangioma has been reported to occur spontaneously in the majority of cases.
  • We report a case of spontaneous rupture of hepatic haemangioma treated by arterial embolisation and conservative means.
  • [MeSH-major] Hemangioma / therapy. Liver Neoplasms / therapy
  • [MeSH-minor] Embolization, Therapeutic. Female. Hepatic Artery / radiography. Humans. Middle Aged. Rupture, Spontaneous. Tomography, X-Ray Computed

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  • (PMID = 19241936.001).
  • [ISSN] 0001-5458
  • [Journal-full-title] Acta chirurgica Belgica
  • [ISO-abbreviation] Acta Chir. Belg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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26. Dong KR, Zheng S, Xiao X: Conservative management of neonatal hepatic hemangioma: a report from one institute. Pediatr Surg Int; 2009 Jun;25(6):493-8
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  • [Title] Conservative management of neonatal hepatic hemangioma: a report from one institute.
  • PURPOSE: To summarize the conservative treatment of neonatal hepatic hemangioma at one institute.
  • PATIENTS AND MATERIALS: Fifteen cases of neonatal hepatic hemangioma were managed in our hospital during the previous 5 years.
  • Initial symptoms, combination symptoms, diagnosis, and treatment were analyzed.
  • Combination symptoms were multiple skin hemangiomas, pneumonia, and cardiac insufficiency.
  • Ultrasound and CT showed the typical characteristics of the liver hemangioma.
  • There were three types of hepatic hemangioma: nine cases had a single focus, four cases were multiple foci, and two had diffuse changes in the liver.
  • One patient having multi-focus in the liver gave up the treatment after biopsy.
  • In those who received conservative therapy, all hemangiomas disappeared within 1 year.
  • CONCLUSION: The diagnosis of hepatic hemangioma can be made from symptomology, ultrasound, and CT; pathologic samples are not necessary.
  • Proactive therapy for congestive heart failure is helpful for those endangering liver hemangioma.
  • Surgery can increase the risk of complications and is not advised for treatment of neonatal hepatic hemangioma.
  • [MeSH-major] Hemangioma / diagnosis. Hemangioma / therapy. Liver Neoplasms / diagnosis. Liver Neoplasms / therapy

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  • (PMID = 19415303.001).
  • [ISSN] 1437-9813
  • [Journal-full-title] Pediatric surgery international
  • [ISO-abbreviation] Pediatr. Surg. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Glucocorticoids
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27. Cha EY, Kim KW, Choi YJ, Song JS, Cho KJ, Lee MG: Multicystic cavernous haemangioma of the liver: ultrasonography, CT, MR appearances and pathological correlation. Br J Radiol; 2008 Feb;81(962):e37-9
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  • [Title] Multicystic cavernous haemangioma of the liver: ultrasonography, CT, MR appearances and pathological correlation.
  • Among the hepatic haemangiomas with atypical features when studied radiologically, the multicystic type is extremely rare.
  • We report a case of multicystic hepatic haemangioma in a 62-year-old woman, which was found incidentally during ultrasound screening.
  • Because the tumour showed atypical features on ultrasonography, CT and MRI, the correct diagnosis was not made until the surgery.
  • [MeSH-major] Hemangioma, Cavernous / diagnosis. Liver Neoplasms / diagnosis
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenoma / diagnosis. Biliary Tract Neoplasms / diagnosis. Diagnosis, Differential. Diagnostic Techniques, Surgical. Female. Humans. Magnetic Resonance Imaging. Middle Aged. Tomography, X-Ray Computed. Ultrasonography

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  • (PMID = 18238911.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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28. Artiko MV, Sobić-Saranović PD, Perisić-Savić SM, Stojković VM, Radoman BI, Knezević SJ, Petrović SN, Obradović BV, Milović V: 99mTc-red blood cells SPECT and planar scintigraphy in the diagnosis of hepatic hemangiomas. Acta Chir Iugosl; 2008;55(4):23-6
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  • [Title] 99mTc-red blood cells SPECT and planar scintigraphy in the diagnosis of hepatic hemangiomas.
  • The aim of the study is the assessment of the value of SPECT (single photon emission computerized tomography) using 99mTc-labeled red blood cells in the detection of liver hemangioma, in comparison to planar imaging.
  • [MeSH-major] Hemangioma / radionuclide imaging. Liver Neoplasms / radionuclide imaging. Sodium Pertechnetate Tc 99m. Tomography, Emission-Computed, Single-Photon
  • [MeSH-minor] Adult. Erythrocytes. Female. Humans. Liver / radionuclide imaging. Male. Middle Aged. Predictive Value of Tests. Sensitivity and Specificity. Young Adult

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  • (PMID = 19245136.001).
  • [ISSN] 0354-950X
  • [Journal-full-title] Acta chirurgica Iugoslavica
  • [ISO-abbreviation] Acta Chir Iugosl
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Serbia
  • [Chemical-registry-number] A0730CX801 / Sodium Pertechnetate Tc 99m
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29. Repiso A, Gómez Rodríguez R, González de Frutos C, de Artaza T, Sánchez Ruano JJ, Pérez Grueso MJ, Martínez Potenciano JL: [Angioma-like liver lesions in patients with chronic liver disease]. Rev Esp Enferm Dig; 2007 May;99(5):259-63
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  • [Title] [Angioma-like liver lesions in patients with chronic liver disease].
  • [Transliterated title] Lesiones hepáticas sugestivas de angioma en pacientes con hepatopatía crónica.
  • OBJECTIVE: The aim of this study was to evaluate in our healthcare area the clinical, ultrasonographic, and evolutionary features of patients with chronic liver disease and angioma-like liver lesions on ultrasonography.
  • Included in the study were patients that presented with clinical and/or laboratory complaints consistent with chronic liver disease of any etiology, and those in which abdominal ultrasounds revealed the existence of at least one angioma-like liver lesion.
  • RESULTS: In the course of our study, 58 patients were diagnosed with chronic liver disease and angioma-like liver lesions, of which 13 showed clinical, laboratory, ultrasonographic, and/or histological signs of liver cirrhosis.
  • In 50% of patients these lesions were less than 10 mm in diameter, and in most cases were located in the right hepatic lobe.
  • During an average follow-up period of 35 months (6-168 months) we verified that, in two patients, these lesions, initially interpreted as angiomas were in fact malignancies (one hepatocellular carcinoma and one metastatic adenocarcinoma of the gallbladder).
  • Thus, our study revealed that 15% of lesions found in cirrhotic patients initially interpreted as angiomas were actually malignant.
  • CONCLUSIONS: Our study revealed that, in patients with chronic liver disease, particularly in cirrhotic patients, a considerable percentage of ultrasonographic lesions originally interpreted as angiomas are in fact malignant tumors.
  • [MeSH-major] Hemangioma / ultrasonography. Liver Cirrhosis / ultrasonography. Liver Neoplasms / ultrasonography
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Chronic Disease. Female. Humans. Liver Diseases / ultrasonography. Male. Middle Aged. Retrospective Studies

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  • (PMID = 17650934.001).
  • [ISSN] 1130-0108
  • [Journal-full-title] Revista española de enfermedades digestivas : organo oficial de la Sociedad Española de Patología Digestiva
  • [ISO-abbreviation] Rev Esp Enferm Dig
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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30. Luo SM, Tan WM, Deng WX, Zhuang SM, Luo JW: Expression of albumin, IGF-1, IGFBP-3 in tumor tissues and adjacent non-tumor tissues of hepatocellular carcinoma patients with cirrhosis. World J Gastroenterol; 2005 Jul 21;11(27):4272-6
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  • ALB mRNA, IGF-1 mRNA, and IGFBP-3 mRNA in liver tissues (including tumor tissues and adjacent non-tumor tissues) were detected by reverse transcriptase-polymerase chain reaction (RT-PCR).
  • Liver Ki67 immunohistochemistry staining was studied.
  • At the same time, 12 patients with cholelithiasis or liver angioma who underwent operation were segregated as normal control.
  • RESULTS: In HCC patients with cirrhosis, hepatic ALB mRNA, IGF-1 mRNA, and IGFBP-3 mRNA of tumor tissues or adjacent non-tumor tissues were lower than the normal liver tissues, while in tumor tissues, hepatic ALB mRNA and IGFBP-3 mRNA were lower, hepatic IGF-1 mRNA was higher than in adjacent non-tumor tissues.
  • Liver Ki67 labeling index (Ki67 LI) in tumor tissues or adjacent non-tumor tissues were higher than that in the normal liver tissues, while in tumor tissues it was higher than that in adjacent non-tumor tissues.
  • CONCLUSION: Imbalance of IGF-1 and IGFBP-3 may play a role in hepatocarcinogenesis and tumor development of liver cirrhosis patients.
  • [MeSH-major] Albumins / genetics. Carcinoma, Hepatocellular / physiopathology. Insulin-Like Growth Factor Binding Protein 3 / genetics. Insulin-Like Growth Factor I / genetics. Liver Neoplasms / physiopathology
  • [MeSH-minor] Gene Expression Regulation, Neoplastic. Humans. Liver Cirrhosis / genetics. Liver Cirrhosis / physiopathology

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  • (PMID = 16015705.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Albumins; 0 / Insulin-Like Growth Factor Binding Protein 3; 67763-96-6 / Insulin-Like Growth Factor I
  • [Other-IDs] NLM/ PMC4615458
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31. Qin J, Wang ZW, Ni QC, Wang Y, Chen L, Lu MD, Shen AG: [Expression and significance of c-jun-activation-domain binding protein (JAB1) in hepatocellular carcinoma]. Zhonghua Yi Xue Za Zhi; 2008 Sep 23;88(36):2533-6
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  • METHODS: Immunohistochemistry was used on 76 specimens of HCC tissues and native liver tissues adjacent to the HCC tissues, and 10 specimens of normal liver tissues near the liver angioma to detect the expression of JAB1 and the cell proliferative factor Ki67.
  • RESULTS: The expression rate of JAB1 in the HHC tissues was 68.85%, significantly higher than that in the adjacent liver tissues and normal liver tissues near liver angioma (38.72% and 34.36% respectively, both P < 0.001).
  • The expression rate of Ki67 protein in the HCC tissues was 41.45%, significantly higher than that in the adjacent liver tissues and normal liver tissues near liver angioma (2.11% and 2.01% respectively, both P < 0.001).
  • JAB1 may be used as a marker for neoplastic change in liver cells and thus has potential clinicopathologic value.
  • [MeSH-major] Carcinoma, Hepatocellular / metabolism. Liver Neoplasms / metabolism. Peptide Hydrolases / biosynthesis

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  • (PMID = 19080643.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Intracellular Signaling Peptides and Proteins; 0 / Ki-67 Antigen; EC 3.4.- / Peptide Hydrolases; EC 3.4.-.- / COPS5 protein, human
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32. Han SL, Wu XL, Jia ZR, Wang PF: Adult hepatic cavernous haemangioma with highly elevated alpha-fetoprotein. Hong Kong Med J; 2010 Oct;16(5):400-2
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  • [Title] Adult hepatic cavernous haemangioma with highly elevated alpha-fetoprotein.
  • Laboratory examination revealed that his serum alpha-fetoprotein level was 1890 microg/L (reference range, 0-20 microg/L), and computed tomographic scan showed a hypodense lesion in the left liver lobe.
  • At laparotomy, a dark reddish soft tumour (3.0 x 3.5 cm in diameter) was found in the medial segment of the liver (segment III).
  • Intra-operative pathology and postoperative histopathology examinations revealed that the tumour was a cavernous haemangioma of the liver.
  • Clinicians should be aware that some rare tumours besides hepatocellular carcinoma and endodermal sinus tumours (yolk sac tumour), for example, hepatic haemangioma, can produce alpha-fetoprotein.

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  • (PMID = 20890007.001).
  • [ISSN] 1024-2708
  • [Journal-full-title] Hong Kong medical journal = Xianggang yi xue za zhi
  • [ISO-abbreviation] Hong Kong Med J
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / alpha-Fetoproteins
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33. Pinkernelle J, Neumann U, Hänninen EL: An unusual cause of epigastric pain: infected giant liver hemangioma. Acta Radiol; 2007 Mar;48(2):142-4
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  • [Title] An unusual cause of epigastric pain: infected giant liver hemangioma.
  • Computed tomography (CT) demonstrated a giant hemangioma of the liver with an intralesional central mass, which was documented by diameter progression of the central mass on follow-up CT.
  • After liver resection, the diagnosis was an abscess in a giant liver hemangioma.
  • [MeSH-major] Hemangioma / radiography. Liver Abscess / radiography. Liver Neoplasms / radiography. Tomography, X-Ray Computed

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  • (PMID = 17354132.001).
  • [ISSN] 0284-1851
  • [Journal-full-title] Acta radiologica (Stockholm, Sweden : 1987)
  • [ISO-abbreviation] Acta Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Sweden
  • [Chemical-registry-number] 0 / Contrast Media; 9007-41-4 / C-Reactive Protein
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34. Valdés Mas M, Ortiz Sánchez ML, Rodrigo Agudo JL, Miras López M, Pons Miñano JA, Carballo Alvarez F: [Giant hepatic hemangioma associated with Kasabach-Merrit syndrome]. Rev Esp Enferm Dig; 2008 Aug;100(8):511-3
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  • [Title] [Giant hepatic hemangioma associated with Kasabach-Merrit syndrome].
  • [Transliterated title] Hemangioma hepático gigante asociado a síndrome de Kasabach-Merrit.
  • Hepatic hemangioma is the most frequent liver's tumor.
  • We present a patient with a giant hepatic hemangioma with multiple hemangimatosis associated to Kasabach-Merrit syndrome.
  • [MeSH-major] Disseminated Intravascular Coagulation / complications. Hemangioma / complications. Liver Neoplasms / complications

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  • (PMID = 18942906.001).
  • [ISSN] 1130-0108
  • [Journal-full-title] Revista española de enfermedades digestivas : organo oficial de la Sociedad Española de Patología Digestiva
  • [ISO-abbreviation] Rev Esp Enferm Dig
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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35. Hamaloglu E, Altun H, Ozdemir A, Ozenc A: Giant liver hemangioma: therapy by enucleation or liver resection. World J Surg; 2005 Jul;29(7):890-3
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  • [Title] Giant liver hemangioma: therapy by enucleation or liver resection.
  • Hemangioma is the most common primary tumor of the liver.
  • The widespread use of ultrasonography (USG) and computed tomography (CT) has made the diagnosis more common.
  • Although the vast majority of hemangiomas are diagnosed incidentally and are asymptomatic, treatment is still controversial.
  • Surgery is the treatment of choice, especially in giant, symptomatic hemangiomas and uncertainty of diagnosis.
  • Twenty-two patients (median age: 46 years) underwent resection (n = 12) or enucleation (n = 10) for liver hemangioma from 1989 to 2002.
  • Ten patients who were treated by enucleation were compared with twelve patients who were treated by liver resection.
  • There were no statistically significant differences in tumor size, preoperative liver function tests, hemoglobin levels, and platelet counts between the two groups.
  • There were three postoperative complications, 1 in the enucleation group (pleural effusion), 2 in the resection group (liver abscess and wound infection).
  • Although most hemangiomas can be removed by enucleation or liver resection with low morbidity and mortality, if the location and number of hemangiomas are appropriate, enucleation is the choice of the therapy.
  • [MeSH-major] Hemangioma / surgery. Hepatectomy / methods. Liver Diseases / surgery

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  • (PMID = 15951941.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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36. Yun JP, Miao J, Chen GG, Tian QH, Zhang CQ, Xiang J, Fu J, Lai PB: Increased expression of nucleophosmin/B23 in hepatocellular carcinoma and correlation with clinicopathological parameters. Br J Cancer; 2007 Feb 12;96(3):477-84
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  • In this study, we examined NPM expression in 103 paired cases of hepatocellular carcinoma (HCC), 12 cases of hepatic focal nodular hyperplasia, 17 cases of liver tissue adjacent to a hepatic haemangioma, and series of array tissues from normal human organs and malignancies using a monoclonal antibody against NPM and reverse transcription-PCR techniques, Western blot analysis, immunohistochemistry, and immunocytofluorescence.
  • Moreover, enhanced expression of NPM in HCC correlated with the level of PCNA (R(2)=0.5639) and with the clinical prognostic parameters such as serum alpha fetal protein level, tumour pathological grading, and liver cirrhosis (P<0.05).
  • [MeSH-major] Carcinoma, Hepatocellular / chemistry. Liver Neoplasms / chemistry. Nuclear Proteins / analysis

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  • (PMID = 17245342.001).
  • [ISSN] 0007-0920
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Nuclear Proteins; 0 / Proliferating Cell Nuclear Antigen; 117896-08-9 / nucleophosmin
  • [Other-IDs] NLM/ PMC2360035
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37. Bartolotta TV, Taibbi A, Galia M, Lo Re G, La Grutta L, Grassi R, Midiri M: Centrifugal (inside-out) enhancement of liver hemangiomas: a possible atypical appearance on contrast-enhanced US. Eur J Radiol; 2007 Dec;64(3):447-55
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  • [Title] Centrifugal (inside-out) enhancement of liver hemangiomas: a possible atypical appearance on contrast-enhanced US.
  • OBJECTIVE: To report the prevalence and to describe the atypical centrifugal (inside-out) appearance of contrast-enhancement of liver hemangiomas on contrast-enhanced sonography.
  • MATERIALS AND METHODS: Baseline and SonoVue-enhanced ultrasonography of 92 patients with 158 liver hemangiomas - considered atypical at grey-scale examination and confirmed by computed tomography, magnetic resonance imaging and ultrasound follow-up - were reviewed in consensus by two experienced radiologists, who evaluated baseline echogenicity and the dynamic enhancement pattern of each lesion looking for the presence of central enhancing foci in the arterial phase followed by a centrifugal (inside-out) enhancement in the portal-venous and late phases.
  • RESULTS: After administration of SonoVue, 12/158 hemangiomas (7.6%) (size range: 1-7cm; mean: 3.2cm) in seven patients (5 women, 2 men; age range: 34-71 years, mean: 50.8 years) showed a central enhancing focus in the arterial phase followed by a centrifugal enhancement in the portal-venous and late phases.
  • CONCLUSION: Radiologist should be aware that centrifugal (inside-out) appearance on contrast-enhanced sonography is a rare but possible feature of liver hemangioma.
  • [MeSH-major] Contrast Media. Hemangioma / ultrasonography. Image Enhancement / methods. Liver Neoplasms / ultrasonography. Ultrasonography, Doppler / methods
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. Hepatic Artery / pathology. Humans. Image Processing, Computer-Assisted / methods. Magnetic Resonance Imaging. Male. Microbubbles. Middle Aged. Phospholipids. Portal Vein / pathology. Sulfur Hexafluoride. Time Factors. Tomography, X-Ray Computed. Ultrasonography, Doppler, Color / methods. Ultrasonography, Doppler, Pulsed / methods

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  • (PMID = 17433596.001).
  • [ISSN] 0720-048X
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Phospholipids; 0 / contrast agent BR1; WS7LR3I1D6 / Sulfur Hexafluoride
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38. Gourgiotis S, Moustafellos P, Zavos A, Dimopoulos N, Vericouki C, Hadjiyannakis EI: Surgical treatment of hepatic haemangiomas: a 15-year experience. ANZ J Surg; 2006 Sep;76(9):792-5
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  • [Title] Surgical treatment of hepatic haemangiomas: a 15-year experience.
  • BACKGROUND: Hepatic haemangiomas are congenital vascular malformations.
  • They are the most common benign tumours of the liver and are often asymptomatic.
  • We present our experience over the last 15 years with the surgical management of 15 liver haemangiomas to clarify the safety and effectiveness of this treatment.
  • METHODS: There were 15 patients with hepatic haemangiomas who were surgically treated from 1990 to 2004.
  • Indications for the operation were spontaneous or traumatic rupture, consumption coagulopathy, rapid growth, abdominal pain and uncertain diagnosis.
  • Methods for diagnosis included ultrasonography, computed tomography scan, magnetic resonance imaging and selective hepatic arteriography or combinations of more than one technique.
  • CONCLUSION: The resection of the hepatic haemangioma is safe.
  • [MeSH-major] Hemangioma / surgery. Liver Neoplasms / surgery

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  • (PMID = 16922900.001).
  • [ISSN] 1445-1433
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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39. Ontachi Y, Asakura H, Omote M, Yoshida T, Matsui O, Nakao S: Kasabach-Merritt syndrome associated with giant liver hemangioma: the effect of combined therapy with danaparoid sodium and tranexamic acid. Haematologica; 2005 Nov;90 Suppl:ECR29
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  • [Title] Kasabach-Merritt syndrome associated with giant liver hemangioma: the effect of combined therapy with danaparoid sodium and tranexamic acid.
  • A 39-year-old woman with an enlarging giant liver hemangioma was diagnosed as having KMS with DIC.
  • Rapid improvement of the bleeding tendency and coagulopathy occurred in response to this treatment - that is, DIC was controlled without removing the giant hemangioma.
  • [MeSH-major] Antifibrinolytic Agents / therapeutic use. Chondroitin Sulfates / therapeutic use. Dermatan Sulfate / therapeutic use. Disseminated Intravascular Coagulation / etiology. Hemangioma / complications. Hemorrhagic Disorders / etiology. Heparitin Sulfate / therapeutic use. Liver Neoplasms / complications. Tranexamic Acid / therapeutic use
  • [MeSH-minor] Adult. Blood Proteins / analysis. Drug Therapy, Combination. Female. Hepatic Artery / surgery. Humans. Ligation. Syndrome

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  • (PMID = 16266920.001).
  • [ISSN] 1592-8721
  • [Journal-full-title] Haematologica
  • [ISO-abbreviation] Haematologica
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antifibrinolytic Agents; 0 / Blood Proteins; 24967-94-0 / Dermatan Sulfate; 6T84R30KC1 / Tranexamic Acid; 83513-48-8 / danaproid; 9007-28-7 / Chondroitin Sulfates; 9050-30-0 / Heparitin Sulfate
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40. R Aglyamov S, R Skovoroda A, Xie H, Kim K, M Rubin J, O'Donnell M, W Wakefield T, Myers D, Y Emelianov S: Model-based reconstructive elasticity imaging using ultrasound. Int J Biomed Imaging; 2007;2007:35830
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  • The model-based approach is illustrated using two potential clinical applications: differentiation of liver hemangioma and staging of deep venous thrombosis.

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  • (PMID = 18256732.001).
  • [ISSN] 1687-4188
  • [Journal-full-title] International journal of biomedical imaging
  • [ISO-abbreviation] Int J Biomed Imaging
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / R01 HL068658
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1986825
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41. Quaia E, Bartolotta TV, Midiri M, Cernic S, Belgrano M, Cova M: Analysis of different contrast enhancement patterns after microbubble-based contrast agent injection in liver hemangiomas with atypical appearance on baseline scan. Abdom Imaging; 2006 Jan-Feb;31(1):59-64
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Analysis of different contrast enhancement patterns after microbubble-based contrast agent injection in liver hemangiomas with atypical appearance on baseline scan.
  • BACKGROUND: We describe different possible enhancement patterns in liver hemangiomas with atypical appearance on baseline ultrasound after microbubble-based contrast agent injection.
  • METHODS: From a series of 253 consecutive lesions that were indeterminate on baseline ultrasound and then scanned after injection of air-filled microbubble contrast agent, 65 focal liver lesions were retrospectively selected on the basis of a diagnosis of liver hemangioma on multiphase contrast-enhanced computed tomography (n = 23), magnetic resonance imaging (n = 27), or histology (n = 15).
  • RESULTS: Centripetal fill-in preceded (n = 50) or not preceded (n = 3) by peripheral nodular/rim-like enhancement was the prevalently observed contrast-enhancement pattern, equivalent to the typical enhancement pattern of liver hemangiomas on contrast-enhanced computed tomography or magnetic resonance imaging.
  • CONCLUSION: Different contrast-enhancement patterns are possible in atypical liver hemangiomas after microbubble injection.
  • Typical centripetal fill-in is the prevalent pattern and its evidence allows diagnosis.
  • [MeSH-major] Hemangioma / ultrasonography. Liver Neoplasms / ultrasonography
  • [MeSH-minor] Adult. Aged. Contrast Media / administration & dosage. Female. Humans. Image Enhancement. Liver Cirrhosis / ultrasonography. Male. Microbubbles. Middle Aged. Polysaccharides / administration & dosage

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  • (PMID = 16333704.001).
  • [ISSN] 0942-8925
  • [Journal-full-title] Abdominal imaging
  • [ISO-abbreviation] Abdom Imaging
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Polysaccharides; 127279-08-7 / SHU 508
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42. Kornasiewicz O, Debski M, Stepnowska M, Szałas A, Bar-Andziak E, Krawczyk M: The enzymatic activity of type 1 iodothyronine deiodinase (D1) is low in liver hemangioma: a preliminary study. Arch Immunol Ther Exp (Warsz); 2010 Feb;58(1):77-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The enzymatic activity of type 1 iodothyronine deiodinase (D1) is low in liver hemangioma: a preliminary study.
  • However, there are few available data about D1 enzyme activity in benign tumors such as hemangioma, which is the most common primary liver tumor.
  • Hence this study aimed to determine the enzymatic activity of D1 in hemangiomas in relation to healthy liver tissue.
  • Seven tumors and healthy control tissues were obtained from patients who had liver resection due to hemangioma.
  • It was found that D1 activity was significantly lower in the hemangiomas than in the healthy surrounding tissue (p = 0.0017).
  • Healthy liver tissue expresses a high level of D1, but disturbed D1 activity may result in changes in the local concentration of T3 which may impair gene transcription.
  • These finding demonstrate a low enzymatic activity of D1 in liver hemangioma and suggest an as yet unknown role of thyroid hormones in this type of benign liver tumor.
  • [MeSH-major] Hemangioma / enzymology. Iodide Peroxidase / metabolism. Liver / enzymology. Liver Neoplasms / enzymology

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  • (PMID = 20049650.001).
  • [ISSN] 1661-4917
  • [Journal-full-title] Archivum immunologiae et therapiae experimentalis
  • [ISO-abbreviation] Arch. Immunol. Ther. Exp. (Warsz.)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] EC 1.11.1.- / iodothyronine deiodinase type I; EC 1.11.1.8 / Iodide Peroxidase
  • [Other-IDs] NLM/ PMC2816262
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43. Goshima S, Kanematsu M, Watanabe H, Kondo H, Shiratori Y, Onozuka M, Moriyama N: Hepatic hemangioma and metastasis: differentiation with gadoxetate disodium-enhanced 3-T MRI. AJR Am J Roentgenol; 2010 Oct;195(4):941-6
Hazardous Substances Data Bank. GADOPENTETATE DIMEGLUMINE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hepatic hemangioma and metastasis: differentiation with gadoxetate disodium-enhanced 3-T MRI.
  • OBJECTIVE: The purpose of this study was to evaluate the gadoxetate disodium-enhanced MRI findings of hepatic hemangioma and to investigate the diagnostic performance in differentiating hepatic hemangioma and metastasis.
  • MATERIALS AND METHODS: Images of 32 hepatic hemangiomas in 25 patients and of 29 hepatic metastatic lesions in 20 patients were retrospectively reviewed.
  • MRI findings and performance with respect to the differential diagnosis of hemangioma and metastasis were assessed.
  • RESULTS: During the hepatic arterial phase, 11 of the 32 hemangiomas (34%) exhibited early total enhancement, and nine (28%) exhibited peripheral nodular enhancement.
  • Twenty-three of the 29 metastatic lesions (79%) exhibited ring enhancement during the hepatic arterial phase.
  • Twenty-nine hemangiomas (91%) and all of the metastatic lesions exhibited homogeneous or heterogeneous hypointensity during the hepatobiliary phase.
  • The sensitivity, specificity, and area under the receiver operating characteristic curve for the detection of hemangioma were 76%, 81%, and 0.87 for the hepatobiliary phase alone; 97%, 88%, and 0.97 for the dynamic extracellular phase alone; and 97%, 88%, and 0.98 for the combination.
  • Five nodules smaller than 1 cm (four hemangiomas, one metastatic lesion) that exhibited no enhancement during the arterial phase and minimal enhancement during the late dynamic phase were not differentiated.
  • CONCLUSION: Gadoxetate disodium-enhanced MRI was found useful for differentiating hepatic hemangiomas and metastatic lesions, especially during the dynamic extracellular phase.
  • [MeSH-major] Contrast Media. Gadolinium DTPA. Hemangioma / diagnosis. Liver Neoplasms / diagnosis. Liver Neoplasms / secondary. Magnetic Resonance Imaging
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 20858822.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 0 / gadolinium ethoxybenzyl DTPA; K2I13DR72L / Gadolinium DTPA
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44. Plackett TP, Lin-Hurtubise KM: Hepatic hemangiomas and parachuting. Aviat Space Environ Med; 2008 Oct;79(10):986-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hepatic hemangiomas and parachuting.
  • Hepatic hemangiomas are relatively common benign hepatic tumors.
  • The following case report discusses an individual patient incidentally found to have large hepatic hemangiomas on CT scan during work-up for a traumatic minimally displaced pelvic fracture from parachuting.
  • Interventional radiology was also consulted regarding his fitness to continue parachuting given his large hepatic hemangiomas.
  • Consequently, a hepatic hemangioma should not exclude an individual from parachuting.
  • [MeSH-major] Aerospace Medicine. Aviation. Hemangioma / therapy. Liver Neoplasms / therapy
  • [MeSH-minor] Accidents, Aviation. Adult. Fractures, Bone / etiology. Hemangioma, Cavernous. Humans. Incidental Findings. Liver / injuries. Male. Pubic Bone / injuries. Rupture

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  • (PMID = 18856190.001).
  • [ISSN] 0095-6562
  • [Journal-full-title] Aviation, space, and environmental medicine
  • [ISO-abbreviation] Aviat Space Environ Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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45. Akamatsu N, Sugawara Y, Komagome M, Ishida T, Shin N, Cho N, Ozawa F, Hashimoto D: Giant liver hemangioma resected by trisectorectomy after efficient volume reduction by transcatheter arterial embolization: a case report. J Med Case Rep; 2010;4:283

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant liver hemangioma resected by trisectorectomy after efficient volume reduction by transcatheter arterial embolization: a case report.
  • INTRODUCTION: Liver hemangiomas are the most common benign liver tumors, usually small in size and requiring no treatment.
  • Giant hemangiomas complicated with consumptive coagulopathy (Kasabach-Merritt syndrome) or causing severe incapacitating symptoms, however, are generally considered an absolute indication for surgical resection.
  • Here, we present the case of a giant hemangioma, which was, to the best of our knowledge, one of the largest ever reported.
  • Examinations at the first visit revealed a right liver hemangioma occupying the abdominal cavity, protruding into the right diaphragm up to the right thoracic cavity and extending down to the pelvic cavity, with a maximum diameter of 43 cm, complicated with "asymptomatic" Kasabach-Merritt syndrome.
  • Based on the tumor size and the anatomic relationship between the tumor and hepatic vena cava, primary resection seemed difficult and dangerous, leading us to first perform transcatheter arterial embolization to reduce the tumor volume and to ensure the safety of future resection.
  • CONCLUSIONS: To date, there have been several reports of aggressive surgical treatments, including extra-corporeal hepatic resection and liver transplantation, for huge hemangiomas like the present case, but because of its benign nature, every effort should be made to avoid life-threatening surgical stress for patients.
  • Our experience demonstrates that a pre-operative arterial embolization may effectively enable the resection of large hemangiomas.

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  • (PMID = 20731839.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2936318
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46. Aksenov IV, Fedorchenko AN: [Hepatic hemangioma: the choice of treatment]. Khirurgiia (Mosk); 2010;(6):40-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Hepatic hemangioma: the choice of treatment].
  • 117 patients with hepatic hemangioma were treated.
  • The possibility and technical features of liver resections by hepatic hemangiomas are discussed.
  • Authors state the necessity of reduction of surgical treatment of hepatic hemangiomas and substantiate the need of dynamic observation of such lesions of the liver.
  • [MeSH-major] Hemangioma / surgery. Liver Neoplasms / surgery

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  • (PMID = 20559223.001).
  • [ISSN] 0023-1207
  • [Journal-full-title] Khirurgiia
  • [ISO-abbreviation] Khirurgiia (Mosk)
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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47. Sahiner UM, Senel S, Erkek N, Karacan C, Yoney A: Rubinstein Taybi syndrome with hepatic hemangioma. Med Princ Pract; 2009;18(2):162-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Rubinstein Taybi syndrome with hepatic hemangioma.
  • OBJECTIVE: It was the aim of our study to present a case of Rubinstein Taybi syndome (RTS) associated with hepatic hemangioma.
  • He had large areas of cutaneous capillary hemangiomas.
  • Radiological examination revealed a hepatic hemangioma.
  • A multidisciplinary follow-up program was commenced and hepatic ultrasound examinations were performed periodically.
  • CONCLUSION: This case shows an association between RTS and hepatic hemangioma, and hence, we recommend regular hepatic ultrasound examination when RTS is suspected or diagnosed.
  • [MeSH-major] Hemangioma / complications. Liver Neoplasms / complications. Rubinstein-Taybi Syndrome / complications

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  • [Copyright] Copyright 2009 S. Karger AG, Basel.
  • (PMID = 19204439.001).
  • [ISSN] 1423-0151
  • [Journal-full-title] Medical principles and practice : international journal of the Kuwait University, Health Science Centre
  • [ISO-abbreviation] Med Princ Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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48. Dardenne S, Hubert C, Sempoux C, Annet L, Jouret-Mourin A, Horsmans Y, Van Beers BE, Zech F, Gigot JF: Conservative and operative management of benign solid hepatic tumours: a successful stratified algorithm. Eur J Gastroenterol Hepatol; 2010 Nov;22(11):1337-44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Conservative and operative management of benign solid hepatic tumours: a successful stratified algorithm.
  • BACKGROUND: The progress of modern imaging studies has improved the diagnostic approach of benign liver tumours, leading to a tailored approach with increased conservative management.
  • METHODS: One hundred and thirty-two patients suffering from benign hepatic tumours were enrolled in this study, including an operative (group I, 49 patients) and a conservative (group II, 83 patients) management.
  • Indication for resection based on diagnosis of tumour nature (hepatic cell adenoma or uncertain diagnosis) and significant tumour-related abdominal pain was 15% out of 33 patients with hepatic haemangioma, 21.7% out of 60 patients with focal nodular hyperplasia and 78.4% out of 37 patients with hepatocellular adenoma.
  • Interestingly, 87.9% of all observed benign liver tumours remained stable, decreased in size or disappeared.
  • CONCLUSION: A restrictive policy of surgical management of benign liver tumours based on clinical symptoms, tumour size and nature on imaging studies (including dubious lesions) and tumour biopsies in selected cases is safe and reliable with a low-operative mortality in resected patients and satisfactory disease-control in the vast majority of observed benign liver tumours.
  • [MeSH-major] Adenoma, Liver Cell / therapy. Algorithms. Critical Pathways. Focal Nodular Hyperplasia / therapy. Hemangioma / therapy. Hepatectomy. Laparoscopy. Liver Neoplasms / therapy

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  • (PMID = 20683192.001).
  • [ISSN] 1473-5687
  • [Journal-full-title] European journal of gastroenterology & hepatology
  • [ISO-abbreviation] Eur J Gastroenterol Hepatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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49. Ardeshiri A, Ardeshiri A, Beiras-Fernandez A, Steinlein OK, Winkler PA: Multiple cerebral cavernous malformations associated with extracranial mesenchymal anomalies. Neurosurg Rev; 2008 Jan;31(1):11-7; discussion 17-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multiple cerebral cavernous malformations associated with extracranial mesenchymal anomalies.
  • Cerebral cavernous malformations (CCM) are common hamartous dysplasias characterized by abnormally dilated vascular channels.
  • CCM mostly occur sporadically, and multiple occurrence of CCM is highly suggestive of a genetic origin of the disorder.
  • An illustrative case is presented in which CCM occurred together with different dysplasias (multiple CCM, liver cavernoma, and cardiac atrial myxoma), which are all thought to arise from abnormal mesenchymal cell differentiation processes.
  • [MeSH-major] Central Nervous System Neoplasms. Hemangioma, Cavernous, Central Nervous System. Neoplastic Syndromes, Hereditary
  • [MeSH-minor] Carrier Proteins / genetics. Female. Heart Neoplasms / diagnosis. Heart Neoplasms / genetics. Humans. Magnetic Resonance Imaging. Microtubule-Associated Proteins / genetics. Middle Aged. Myxoma / diagnosis. Myxoma / genetics. Proto-Oncogene Proteins / genetics

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  • (PMID = 17957396.001).
  • [ISSN] 0344-5607
  • [Journal-full-title] Neurosurgical review
  • [ISO-abbreviation] Neurosurg Rev
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / CCM2 protein, human; 0 / Carrier Proteins; 0 / KRIT1 protein, human; 0 / Microtubule-Associated Proteins; 0 / Proto-Oncogene Proteins
  • [Number-of-references] 63
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50. Brogna A, Ferrara R, Bucceri AM, Virgilio C, Scalisi G: An atypical case of hepatic cavernous hemangioma. Cases J; 2009;2:181

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An atypical case of hepatic cavernous hemangioma.
  • INTRODUCTION: The case of an atypical hepatic angiocavernoma is referred.
  • Abdominal ultrasound showed a large, roughly round-shaped lesion (diameter 14 cm) in the VIII hepatic segment diagnosed as hepatic angiocavernoma, which turned unexpectedly in a cystic like lesion one year later.
  • CONCLUSION: The atypical angioma's degeneration could account for one of the causes of the patient's exitus.
  • It could be related to blood seizure by the large hepatic angioma due to the intratumoural haemorrhage.

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  • (PMID = 19946491.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2783136
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51. Turowski C, Feist H, Alzen G, Glüer S, Petersen C: Conversion of a neonatal hepatic hemangioma to focal nodular hyperplasia. Pathol Int; 2009 Apr;59(4):251-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Conversion of a neonatal hepatic hemangioma to focal nodular hyperplasia.
  • Hepatic hemangioma and focal nodular hyperplasia are both frequently observed benign lesions of the liver.
  • Whereas hepatic hemangioma is the most frequent benign liver tumor in children, focal nodular hyperplasia occurs predominantly in adult patients.
  • We report on a 6-month-old child with a continuously shrinking hepatic hemangioma after interventional therapy and a growing hepatic mass 5 years later, which emerged as focal nodular hyperplasia at the site of the former hemangioma.
  • [MeSH-major] Focal Nodular Hyperplasia / pathology. Hemangioma / pathology. Liver Neoplasms / pathology

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  • (PMID = 19351369.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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52. Jiang WS, Lu BY, Cai XY, Lu WQ, Liu ZJ, Huang F, Jin XJ: [Laparoscope hepatectomy for hepatic hemangioma: a report of 18 cases]. Zhonghua Wai Ke Za Zhi; 2007 Oct 1;45(19):1311-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Laparoscope hepatectomy for hepatic hemangioma: a report of 18 cases].
  • OBJECTIVE: To evaluate the feasibility and practicality of laparoscopic hepatectomy for hepatic hemangioma.
  • METHODS: Candidate for laparoscopic liver resection were 18 cases of hepatic hemangioma from January 2002 to October 2006.
  • The Electric-cautery and ultracision were used for liver transection.
  • Operative procedures included anatomical left hepatectomy in 2 cases, non-anatomical left hepatectomy 1 case, left lobectomy 5 cases, local liver resection 10 cases.
  • Two cases of hepatic hemangioma associated with gallbladder stone were performed cholecystectomy synchronously, 1 case associated with chronic appendicitis were performed appendectomy synchronously.
  • RESULTS: Laparoscopic left liver resection was successfully performed in all 18 cases.
  • CONCLUSION: Laparoscope hepatectomy for hepatic hemangioma is safe and feasible.
  • [MeSH-major] Hemangioma / surgery. Hepatectomy / methods. Laparoscopy. Liver Neoplasms / surgery

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  • (PMID = 18241562.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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53. Jennings RT, Garriott OK, Bogomolov VV, Pochuev VI, Morgun VV, Garriott RA: Giant hepatic hemangioma and cross-fused ectopic kidney in a spaceflight participant. Aviat Space Environ Med; 2010 Feb;81(2):136-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant hepatic hemangioma and cross-fused ectopic kidney in a spaceflight participant.
  • During the evaluation for the left single cross-fused ectopic kidney, a giant hepatic hemangioma was also discovered.
  • In order to medically qualify for flight, the giant hepatic hemangioma was surgically removed.
  • This case summary investigat*es the implications of a single cross-fused left ectopic kidney and the decision process and treatment implications for spaceflight medical certification in an individual with an asymptomatic giant hepatic hemangioma.
  • [MeSH-major] Hemangioma / surgery. Kidney / abnormalities. Liver Neoplasms / surgery. Space Flight
  • [MeSH-minor] Adult. Decision Making. Diagnosis, Differential. Humans. International Cooperation. Male. Postoperative Period. Russia. Tomography, X-Ray Computed

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  • (PMID = 20131656.001).
  • [ISSN] 0095-6562
  • [Journal-full-title] Aviation, space, and environmental medicine
  • [ISO-abbreviation] Aviat Space Environ Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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54. Dickie B, Dasgupta R, Nair R, Alonso MH, Ryckman FC, Tiao GM, Adams DM, Azizkhan RG: Spectrum of hepatic hemangiomas: management and outcome. J Pediatr Surg; 2009 Jan;44(1):125-33
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spectrum of hepatic hemangiomas: management and outcome.
  • PURPOSE: Infants with multiple cutaneous hemangiomas often present with hepatic hemangiomas.
  • They can follow a benign clinical course or require complex management.
  • We reviewed our experience in the management of hepatic hemangiomas.
  • METHODS: We performed a retrospective review of patients (1996-2007) with hepatic hemangiomas treated in our institution.
  • RESULTS: Twenty-six patients were diagnosed with hepatic hemangiomas as follows: 8 focal, 12 multiple, and 6 diffuse lesions.
  • Nineteen (73%) patients had associated cutaneous hemangiomas.
  • Sixteen patients had multiple and 3 patients had single cutaneous hemangiomas.
  • All patients with multiple or diffuse liver lesions were screened for heart failure and hypothyroidism.
  • Two patients went on to surgical resection for failed response to medical management and worsening heart failure (left lobectomy, liver transplant).
  • Five patients had a previously undescribed constellation of rapidly involuting cutaneous hemangiomas (gone by 3 months, glut-1-negative) with associated liver lesions also resolving at a faster pace (mean resolution of cutaneous hemangiomas, 1.9 vs 7.9 months; P = .001; liver, 5.8 vs 25.3 months; P = .004).
  • CONCLUSION: Patients with multiple cutaneous hemangiomas should be screened for hepatic lesions.
  • Patients with diffuse or multifocal liver hemangiomas should be screened for congestive heart failure and hypothyroidism.
  • A subgroup of rapidly involuting cutaneous hemangiomas have a significantly shorter time for involution of hepatic lesions.
  • The status of cutaneous lesions can be used as indicators for the liver hemangiomas.
  • [MeSH-major] Hemangioma / classification. Hemangioma / therapy. Liver Neoplasms / classification. Liver Neoplasms / therapy

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  • (PMID = 19159729.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Glucocorticoids
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55. Seitz K, Strobel D, Bernatik T, Blank W, Friedrich-Rust M, Herbay Av, Dietrich CF, Strunk H, Kratzer W, Schuler A: Contrast-Enhanced Ultrasound (CEUS) for the characterization of focal liver lesions - prospective comparison in clinical practice: CEUS vs. CT (DEGUM multicenter trial). Parts of this manuscript were presented at the Ultrasound Dreiländertreffen 2008, Davos. Ultraschall Med; 2009 Aug;30(4):383-9
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  • [Title] Contrast-Enhanced Ultrasound (CEUS) for the characterization of focal liver lesions - prospective comparison in clinical practice: CEUS vs. CT (DEGUM multicenter trial). Parts of this manuscript were presented at the Ultrasound Dreiländertreffen 2008, Davos.
  • AIM: The aim of our study was to evaluate the diagnostic value of Contrast-Enhanced Ultrasound (CEUS) for the characterization of focal liver lesions in a prospective multi-center study in clinical practice.
  • MATERIAL AND METHODS: 1349 patients with unclear liver lesions after fundamental ultrasound diagnostics including color doppler analysis were examined with standardized CEUS (pulse inversion method, mechanical index < 0.4) from May 2004 to December 2006 in 14 hospitals in a prospective study.
  • The enhancement of contrast medium in the liver tumors was analyzed according to known tumor-specific vascular patterns, using standardized documentation and analysis methods for the differentiation of tumor differentiation (malign or benign) and tumor specification (entity).
  • Final diagnosis was based on histology, SCT or MRI in typical findings of liver hemangioma and FNH and on proved clinical data and additional follow up.
  • In 109 of these patients (subgroup A) there was no histological verification, diagnoses based on clear SCT-findings in 79 cases of hemangioma or FNH, as well as in 20 cases with a clear clinical diagnosis.
  • In 158 patients (subgroup B) a histological finding was also present, only in 4 cases no definitive tumor diagnosis was achieved.
  • The analysis of particular tumor specification showed a statistically non significant slight advantage in tumor differentiation for CEUS in the case of hemangioma, FNH, HCC and metastases.
  • CEUS should be employed before computed tomography is performed for the differentiation of liver tumors, because radiation exposure and invasive biopsies can be avoided in veritable numbers of cases, when precise clinical evaluation of the findings is implemented.
  • [MeSH-major] Carcinoma, Hepatocellular / blood supply. Carcinoma, Hepatocellular / diagnosis. Contrast Media / administration & dosage. Focal Nodular Hyperplasia / diagnosis. Hemangioma / diagnosis. Liver Neoplasms / blood supply. Liver Neoplasms / diagnosis. Liver Neoplasms / secondary. Neovascularization, Pathologic / diagnosis. Tomography, Spiral Computed. Ultrasonography
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biopsy. Child. Female. Humans. Liver / blood supply. Liver / pathology. Magnetic Resonance Imaging. Male. Middle Aged. Prospective Studies. Sensitivity and Specificity. Young Adult

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  • [Copyright] (c) Georg Thieme Verlag KG Stuttgart, New York.
  • (PMID = 19688670.001).
  • [ISSN] 1438-8782
  • [Journal-full-title] Ultraschall in der Medizin (Stuttgart, Germany : 1980)
  • [ISO-abbreviation] Ultraschall Med
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media
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56. Takahashi K, Iida K, Okimura Y, Takahashi Y, Naito J, Nishikawa S, Kadowaki S, Iguchi G, Kaji H, Chihara K: A novel mutation in the von Hippel-Lindau tumor suppressor gene identified in a Japanese family with pheochromocytoma and hepatic hemangioma. Intern Med; 2006;45(5):265-9
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  • [Title] A novel mutation in the von Hippel-Lindau tumor suppressor gene identified in a Japanese family with pheochromocytoma and hepatic hemangioma.
  • A heterozygous VHL gene-disrupted model (vhl +/-) developed hepatic vascular lesions; in contrast, hepatic hemangioma is a rare manifestation of human VHL syndrome.
  • One of the members demonstrated hepatic hemangiomas, suggesting that there may be a relationship between the mutation of the VHL gene and hepatic vascular lesions, even in humans.
  • [MeSH-major] Adrenal Gland Neoplasms / genetics. Hemangioma / genetics. Liver Neoplasms / genetics. Neoplasms, Multiple Primary / genetics. Pheochromocytoma / genetics. Von Hippel-Lindau Tumor Suppressor Protein / genetics


57. Losanoff JE, Millis JM: Liver hemangioma complicated by obstructive jaundice. Am J Surg; 2008 Sep;196(3):e3-4
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  • [Title] Liver hemangioma complicated by obstructive jaundice.
  • This report describes a liver hemangioma causing obstructive jaundice, an extremely rare condition that has been reported on 3 previous occasions.
  • A hemangioma can compress the major bile ducts and require partial hepatectomy for a successful outcome.
  • [MeSH-major] Hemangioma, Cavernous / complications. Jaundice, Obstructive / etiology. Liver Neoplasms / complications

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  • (PMID = 18519125.001).
  • [ISSN] 1879-1883
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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58. Di Carlo I, Sofia M, Toro A: Does the psychological request of the patient justify the surgery for hepatic hemangioma? Hepatogastroenterology; 2005 May-Jun;52(63):657-61
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  • [Title] Does the psychological request of the patient justify the surgery for hepatic hemangioma?
  • BACKGROUND/AIMS: The incidental finding of hemangiomas has increased, but the problem of the correct surgical indications of this tumor has yet to be solved.
  • The aim of this work is to establish whether the psychological request of surgery from patients known to have a benign tumor of the liver must be avoided or not.
  • METHODOLOGY: Age, sex, symptoms, estroprogestinic oral therapy, methods of diagnosis, surgical procedures, morbidity, mortality, postoperative hospital stay and follow-up of the patients affected by hepatic hemangioma, observed from 1992 to 2002 in our institution, have been considered.
  • RESULTS: Seventeen patients, with a mean age of 44 years (range 26-72), were hospitalized for hepatic hemangioma, 8 (47%) of them were operated on and 9 (53%) were managed by observation.
  • One patient was operated on for traumatic rupture of the hemangioma.
  • The types of surgical procedures were 5 enucleations, and 3 hepatic resections.
  • CONCLUSIONS: Our results suggest that liver hemangiomas should be operated for symptoms well related to the tumor or for bleeding.
  • [MeSH-major] Hemangioma, Cavernous / psychology. Sick Role

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  • (PMID = 15966176.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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59. Kim HG, Park IS, Lee JI, Jeong S, Lee JW, Kwon KS, Lee DH, Kim PS, Kim HG, Shin YW, Kim YS, Ahn IS, Lee KY: Littoral cell angioma (LCA) associated with liver cirrhosis. Yonsei Med J; 2005 Feb 28;46(1):184-8
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  • [Title] Littoral cell angioma (LCA) associated with liver cirrhosis.
  • A littoral cell angioma (LCA) is a rare benign vascular tumor of the spleen.
  • A 60-year-old man, with multiple nodules in imaging study and liver cirrhosis graded as Child-Pugh classification class A, was transferred for splenomegaly.
  • Because there was no evidence of hematological and visceral malignancy, a splenectomy was performed for a definitive diagnosis.
  • There has been no previous report of a LCA combined with liver cirrhosis.
  • [MeSH-major] Hemangioma / complications. Liver Cirrhosis / complications. Splenic Neoplasms / complications

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  • [Cites] AJR Am J Roentgenol. 1999 Apr;172(4):933-7 [10587123.001]
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  • (PMID = 15744827.001).
  • [ISSN] 0513-5796
  • [Journal-full-title] Yonsei medical journal
  • [ISO-abbreviation] Yonsei Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2823050
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60. Zviniene K, Zaboriene I, Basevicius A, Jurkiene N, Barauskas G, Pundzius J: Comparative diagnostic value of contrast-enhanced ultrasonography, computed tomography, and magnetic resonance imaging in diagnosis of hepatic hemangiomas. Medicina (Kaunas); 2010;46(5):329-35
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparative diagnostic value of contrast-enhanced ultrasonography, computed tomography, and magnetic resonance imaging in diagnosis of hepatic hemangiomas.
  • AIM: To compare the value of intravenous contrast-enhanced ultrasonography (US), intravenous contrast-enhanced computed tomography (CT), and magnetic resonance imaging (MRI) in the diagnosis of hepatic hemangiomas.
  • All patients underwent intravenous contrast-enhanced US, intravenous contrast-enhanced CT, and MRI and were diagnosed with hepatic hemangioma according to the findings of these examinations.
  • RESULTS: The size of hemangiomas was < or =2.0 cm in 20 cases (41.7%) and >2.0 cm in 28 (58.3%).
  • No association between hepatic hemangioma and patient's age was found (chi(2)=0.547, df=2, P=0.761).
  • Nearly one-third of hemangiomas were located in the segment IV of the left hepatic lobe.
  • There were a few complicated hemangiomas in the study sample: 2 with calcification and 1 with necrosis.
  • The sensitivity of CT in the diagnosis of hepatic hemangioma was 76.92%; specificity, 33.3%; positive prognostic value, 83.3%; and negative prognostic value, 25.0%.
  • The sensitivity of intravenous contrast-enhanced US in the diagnosis of hepatic hemangioma was 77.8%; specificity, 100%; positive prognostic value, 100%; and negative prognostic value, 23.1%.
  • CONCLUSIONS: Intravenous contrast-enhanced US is more specific than intravenous contrast-enhanced CT in the diagnosis of hepatic hemangioma (P=0.0005) and has a higher positive prognostic value (P=0.001).
  • [MeSH-major] Hemangioma / diagnosis. Liver Neoplasms / diagnosis. Magnetic Resonance Imaging / methods. Tomography, X-Ray Computed / methods. Ultrasonography / methods
  • [MeSH-minor] Adult. Aged. Analysis of Variance. Contrast Media. Data Interpretation, Statistical. Female. Humans. Liver / pathology. Male. Middle Aged. Phospholipids. Sulfur Hexafluoride. Tomography, Emission-Computed, Single-Photon

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  • (PMID = 20679748.001).
  • [ISSN] 1648-9144
  • [Journal-full-title] Medicina (Kaunas, Lithuania)
  • [ISO-abbreviation] Medicina (Kaunas)
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Lithuania
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Phospholipids; 0 / contrast agent BR1; WS7LR3I1D6 / Sulfur Hexafluoride
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61. Lin CH, Yu JC, Shih ML, Peng YJ, Hsieh CB: Littoral cell angioma of the spleen in a patient with hepatocellular carcinoma. J Formos Med Assoc; 2005 Apr;104(4):282-5
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  • [Title] Littoral cell angioma of the spleen in a patient with hepatocellular carcinoma.
  • Littoral cell angioma (LCA) is a rare primitive vascular tumor of the spleen which is benign and usually associated with visceral malignancy.
  • The diagnosis of LCA is based on histologic and immunohistologic analysis.
  • Dynamic computed tomography studies showed splenomegaly (20 cm in long axis) with a hypodense tumor in the upper pole and a contrast-enhanced hepatic mass in the right lobe of the liver.
  • Histopathology showed a moderately differentiated HCC of the liver and splenic angioma with dilated vascular channels lined by plump endothelial cells.

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  • (PMID = 15909068.001).
  • [ISSN] 0929-6646
  • [Journal-full-title] Journal of the Formosan Medical Association = Taiwan yi zhi
  • [ISO-abbreviation] J. Formos. Med. Assoc.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
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62. Banton KL, D'Cunha J, Laudi N, Flynn C, Hammerschmidt D, Humar A, Sielaff T: Postoperative severe microangiopathic hemolytic anemia associated with a giant hepatic cavernous hemangioma. J Gastrointest Surg; 2005 May-Jun;9(5):679-85
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  • [Title] Postoperative severe microangiopathic hemolytic anemia associated with a giant hepatic cavernous hemangioma.
  • Complications related to liver hemangioma are rare.
  • We herein describe the case of a patient with three giant cavernous hemangiomas of the liver, of which two were resected for symptoms.
  • Surgeons should be aware of the potential for hemolytic complications after major surgery when giant hepatic hemangiomas are present.
  • [MeSH-major] Anemia, Hemolytic / etiology. Hemangioma, Cavernous / pathology. Hemangioma, Cavernous / surgery. Liver Neoplasms / pathology. Liver Neoplasms / surgery. Postoperative Complications / diagnosis

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  • (PMID = 15862263.001).
  • [ISSN] 1091-255X
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 25
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63. Chen RC, Li CS, Lii JM, Chen WT, Tu HY: Peritumoral fat-spared area is well correlated with the presence of temporal peritumoral enhancement in hepatic hemangioma in fatty liver. J Magn Reson Imaging; 2005 Jul;22(1):86-91
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  • [Title] Peritumoral fat-spared area is well correlated with the presence of temporal peritumoral enhancement in hepatic hemangioma in fatty liver.
  • PURPOSE: To assess the relationship between temporal peritumoral enhancement and peritumoral focal fat sparing adjacent to hepatic hemangiomas.
  • MATERIALS AND METHODS: On the basis of MRI and sonographic imaging follow-up, 51 hepatic hemangiomas were identified in 37 patients, who had both hepatic hemangiomas and focal fat-sparing areas in fatty liver.
  • The association between the temporal peritumoral enhancement in the early arterial phase of dynamic MRI and peritumoral fat sparing in the same hemangioma was investigated.
  • RESULTS: A total of 31 out of 36 hemangiomas (86.1%) showed both peritumoral focal fat spares and temporal peritumoral enhancement.
  • The remaining 10 hemangiomas showed similar shape but slightly different size in these two imaging characteristics.
  • CONCLUSION: Temporal peritumoral enhancement seen in hepatic hemangioma might be related to focal fatty sparing adjacent to the hemangiomas.
  • [MeSH-major] Fatty Liver / diagnosis. Hemangioma / diagnosis. Liver / pathology. Magnetic Resonance Imaging

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  • (PMID = 15971182.001).
  • [ISSN] 1053-1807
  • [Journal-full-title] Journal of magnetic resonance imaging : JMRI
  • [ISO-abbreviation] J Magn Reson Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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64. Ersoz F, Ozcan O, Toros AB, Culcu S, Bektas H, Sari S, Pasaoglu E, Arikan S: Torsion of a giant pedunculated liver hemangioma mimicking acute appendicitis: a case report. World J Emerg Surg; 2010;5:2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Torsion of a giant pedunculated liver hemangioma mimicking acute appendicitis: a case report.
  • Hemangiomas are the most common benign neoplasms affecting the liver.
  • Rarely, hemangiomas can be pedunculated.
  • At laparotomy a normal appendix was observed and a torsioned pedinculated liver hemangioma turned out to be the cause.

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  • [Cites] Dig Liver Dis. 2010 Jun;42(6):456 [19155194.001]
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  • (PMID = 20148116.001).
  • [ISSN] 1749-7922
  • [Journal-full-title] World journal of emergency surgery : WJES
  • [ISO-abbreviation] World J Emerg Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2820011
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65. Vlahovic A, Simic R, Djokic D, Ceran C: Diffuse neonatal hemangiomatosis treatment with cyclophosphamide: a case report. J Pediatr Hematol Oncol; 2009 Nov;31(11):858-60
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  • There were 63 cutaneous hemangiomas over the scalp, face, trunk, and extremities.
  • Computed tomography scan revealed the presence of hemangiomas in the liver and kidneys; laryngobronchoscopy identified the presence of hemangioma in tracheobronchial tree.
  • After 4 cycles of cyclophosphamide, the liver was notably decreased in size and the cardiac failure was resolved.
  • Magnetic resonance imaging of the abdomen revealed the marked decrease in size of the liver hemangioma.
  • [MeSH-major] Antineoplastic Agents, Alkylating / administration & dosage. Cyclophosphamide / administration & dosage. Hemangioma / drug therapy. Hemangioma / pathology. Mesna / administration & dosage. Protective Agents / administration & dosage

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  • (PMID = 19829152.001).
  • [ISSN] 1536-3678
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 0 / Protective Agents; 8N3DW7272P / Cyclophosphamide; NR7O1405Q9 / Mesna
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66. Vasconcelos L, Silva S, Garcia A, Medeiros D, Albuquerque E Castro J, Capitão LM: [Visceral artery aneurysms: alternative therapeutic approach]. Rev Port Cir Cardiotorac Vasc; 2006 Jul-Sep;13(3):155-8
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  • Case number 2 was a 72 year-old woman with a past medical history significant for hepatic angioma and hypothyroidism.

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  • (PMID = 17057828.001).
  • [ISSN] 0873-7215
  • [Journal-full-title] Revista portuguesa de cirurgia cardio-torácica e vascular : órgão oficial da Sociedade Portuguesa de Cirurgia Cardio-Torácica e Vascular
  • [ISO-abbreviation] Rev Port Cir Cardiotorac Vasc
  • [Language] por
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Portugal
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67. Lee J, Lim HK, Jeon YH: Multiple hepatic hemangiomas with fluid-fluid levels. Australas Radiol; 2007 Dec;51 Suppl:B310-2
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  • [Title] Multiple hepatic hemangiomas with fluid-fluid levels.
  • Hepatic haemangiomas with fluid-fluid levels are known to be rare with only five cases reported in the English literature.
  • According to the previous reports, the presence of fluid-fluid level could attribute to the separation of blood cells and serous fluid because of the extremely slow flow in cavernous haemangioma of the liver.
  • We describe the imaging features of multiple hepatic haemangiomas with fluid-fluid levels, which was pathologically proven with ultrasonography guided biopsy.
  • [MeSH-major] Hemangioma, Cavernous / radiography. Liver Neoplasms / radiography. Magnetic Resonance Imaging. Tomography, X-Ray Computed. Ultrasonography

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  • (PMID = 17991093.001).
  • [ISSN] 0004-8461
  • [Journal-full-title] Australasian radiology
  • [ISO-abbreviation] Australas Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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68. Hering J, Garrean S, Saied A, Helton WS, Espat NJ: Use of radiofrequency hepatic parenchymal transection device in hepatic hemangioma resection: early experience and lessons learned. HPB (Oxford); 2007;9(4):319-23

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  • [Title] Use of radiofrequency hepatic parenchymal transection device in hepatic hemangioma resection: early experience and lessons learned.
  • BACKGROUND: Control of intraoperative hemorrhage represents a significant challenge in hepatic surgery, particularly during resection of large, hypervascular hepatic hemangiomata (HH).
  • Various devices to minimize blood loss from hepatic parenchymal transection are currently under investigation.
  • PATIENTS AND METHODS: From September 2005 to January 2006, we conducted a retrospective review of our hepatobiliary database to identify patients with symptomatic giant cavernous HH undergoing resection with a RF multiarray device.
  • The Habib sealer provided a safe and effective method for hepatic parenchymal transaction.
  • CONCLUSIONS: Hepatic parenchymal transection with the Habib sealer device is a feasible approach to resect HH.

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  • [Cites] J Hepatobiliary Pancreat Surg. 1999;6(4):410-3 [10664292.001]
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  • (PMID = 18345312.001).
  • [ISSN] 1365-182X
  • [Journal-full-title] HPB : the official journal of the International Hepato Pancreato Biliary Association
  • [ISO-abbreviation] HPB (Oxford)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2215404
  • [Keywords] NOTNLM ; Habib™ sealer / RFA / hepatic hemangioma / liver resection
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69. Bessho K, Etani Y, Ichimori H, Miyoshi Y, Namba N, Yoneda A, Ooue T, Chihara T, Morii E, Aoki T, Murakami M, Mushiake S, Ozono K: Increased type 3 iodothyronine deiodinase activity in a regrown hepatic hemangioma with consumptive hypothyroidism. Eur J Pediatr; 2010 Feb;169(2):215-21
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  • [Title] Increased type 3 iodothyronine deiodinase activity in a regrown hepatic hemangioma with consumptive hypothyroidism.
  • INTRODUCTION: Infantile hepatic hemangioma with consumptive hypothyroidism is a rare condition.
  • CASE REPORT: A 4-month-old girl presented with diffuse hepatic hemangiomas during treatment of congenital hypothyroidism.
  • Serum reverse triiodothyronine was elevated, and her hypothyroidism improved concomitant with involution of the hemangioma following prednisolone and interferon-alpha administration.
  • At 20 months of age, 7 months after discontinuing prednisolone and interferon-alpha, a focal hemangioma regrew from one of the previous lesions and was surgically resected.
  • DISCUSSION: Here, we describe a patient with consumptive hypothyroidism and diffuse infantile hepatic hemangiomas, one of which regrew after involution following pharmacotherapy.
  • CONCLUSION: It is important to identify infantile hepatic hemangioma in patients with hypothyroidism refractory to hormone replacement therapy, who have low free triiodothyronine despite high thyrotropin and normal free thyroxine levels, and long-term follow-up will be needed for these patients.
  • [MeSH-major] Hemangioma / enzymology. Hypothyroidism / complications. Iodide Peroxidase / metabolism. Liver Neoplasms / enzymology
  • [MeSH-minor] Biomarkers, Tumor / genetics. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Female. Follow-Up Studies. Gene Expression Regulation, Neoplastic. Humans. Infant. Liver / metabolism. Liver / pathology. Magnetic Resonance Imaging. Polymerase Chain Reaction. RNA, Neoplasm / genetics. Time Factors

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  • (PMID = 19548001.001).
  • [ISSN] 1432-1076
  • [Journal-full-title] European journal of pediatrics
  • [ISO-abbreviation] Eur. J. Pediatr.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / RNA, Neoplasm; EC 1.11.1.- / iodothyronine deiodinase type III; EC 1.11.1.8 / Iodide Peroxidase
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70. Ertan G, Tekes A, Mitchell S, Keefer J, Huisman TA: Pediatric littoral cell angioma of the spleen: multimodality imaging including diffusion-weighted imaging. Pediatr Radiol; 2009 Oct;39(10):1105-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pediatric littoral cell angioma of the spleen: multimodality imaging including diffusion-weighted imaging.
  • Littoral cell angioma (LCA) is a rare primary splenic vascular tumor originating from littoral cells lining the splenic red pulp sinuses.
  • Previous studies on liver lesions have shown that DWI allows differentiation of vascular tumors from primary neoplasms and metastatic disease.
  • The current case indicates that increased ADC values within the splenic lesions suggest a vascular etiology, which might help narrow the differential diagnosis.
  • [MeSH-major] Diffusion Magnetic Resonance Imaging / methods. Hemangioma / diagnosis. Splenic Neoplasms / diagnosis. Tomography, X-Ray Computed / methods. Ultrasonography / methods

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  • (PMID = 19597808.001).
  • [ISSN] 1432-1998
  • [Journal-full-title] Pediatric radiology
  • [ISO-abbreviation] Pediatr Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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71. Kobayashi S, Maruyama H, Okugawa H, Yoshizumi H, Matsutani S, Ebara M, Yokosuka O: Contrast-enhanced US with Levovist for the diagnosis of hepatic hemangioma: time-related changes of enhancement appearance and the hemodynamic background. Hepatogastroenterology; 2008 Jul-Aug;55(85):1222-8
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  • [Title] Contrast-enhanced US with Levovist for the diagnosis of hepatic hemangioma: time-related changes of enhancement appearance and the hemodynamic background.
  • BACKGROUNDS/AIMS: To elucidate the diagnostic confidence of contrast-enhanced ultrasound (CEUS) with Levovist for hepatic hemangioma.
  • METHODOLOGY: The subjects were 34 patients with 38 hemangiomas and 12 patients with 15 hypervascular hepatocellular carcinomas.
  • The early-phase (15-60 second) and liver-specific phase (after 5 min) were observed by the first injection.
  • The 2nd injection was done for solo-phase method to observe liver-specific phase images without taking early-phase sonograms.
  • The 3rd injection was done for changing posture method to observe liver-specific sonograms under left lateral ducubitus position.
  • RESULTS: In the early-phase of hemangioma, nodular enhancement (NE) was found transiently in 13 lesions (34%) and continuously in 25 lesions (66%), while hepatocellular carcinoma (HCC, n = 15) did not show this pattern.
  • Two enhancement patterns were observed in the liver-specific phase of hemangioma, diffuse in 12 lesions (31%) and partial in 26 lesions (69%), which were dependent on the early-phase enhancement.
  • Liver-specific findings were also affected by taking early-phase sonograms or changing the posture of the patient.
  • This method provided sensitivity of 79% and specificity of 100% for the diagnosis of hemangioma.
  • CONCLUSIONS: CEUS with Levovist may be promising method for the diagnosis of hepatic hemangioma.
  • [MeSH-major] Carcinoma, Hepatocellular / ultrasonography. Contrast Media. Hemangioma, Cavernous / ultrasonography. Liver Neoplasms / ultrasonography. Polysaccharides
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cohort Studies. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Retrospective Studies. Sensitivity and Specificity. Time Factors

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  • (PMID = 18795661.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Polysaccharides; 127279-08-7 / SHU 508
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72. Doo KW, Lee CH, Choi JW, Lee J, Kim KA, Park CM: "Pseudo washout" sign in high-flow hepatic hemangioma on gadoxetic acid contrast-enhanced MRI mimicking hypervascular tumor. AJR Am J Roentgenol; 2009 Dec;193(6):W490-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] "Pseudo washout" sign in high-flow hepatic hemangioma on gadoxetic acid contrast-enhanced MRI mimicking hypervascular tumor.
  • OBJECTIVE: The purpose of this article is to describe the "pseudo washout" sign of high-flow hepatic hemangioma that mimics hypervascular tumor on gadoxetic acid-enhanced MRI.
  • CONCLUSION: High-flow hemangiomas might show relatively low signal intensity because of gadoxetic acid contrast uptake in the surrounding normal liver parenchyma during the equilibrium (3-minute delay) phase.
  • Such findings are called pseudo washout and can mimic hypervascular hepatic tumors.
  • However, high-flow hemangioma can be diagnosed by observing bright signal intensity on T2-weighted imaging, arterial phase-dominant enhancement, pseudo washout sign during the equilibrium phase, and isointense or slightly increased signal intensity on subtraction images.
  • [MeSH-major] Gadolinium DTPA. Hemangioma / diagnosis. Liver Neoplasms / diagnosis. Magnetic Resonance Imaging / methods
  • [MeSH-minor] Aged. Biopsy. Contrast Media. Diagnosis, Differential. Humans. Image Interpretation, Computer-Assisted. Male. Middle Aged. Organometallic Compounds. Ultrasonography, Interventional

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  • (PMID = 19933623.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Organometallic Compounds; 0 / gadolinium ethoxybenzyl DTPA; 1BJ477IO2L / gadobutrol; K2I13DR72L / Gadolinium DTPA
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73. Draper H, Diamond IR, Temple M, John P, Ng V, Fecteau A: Multimodal management of endangering hepatic hemangioma: impact on transplant avoidance: a descriptive case series. J Pediatr Surg; 2008 Jan;43(1):120-5; discussion 126
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multimodal management of endangering hepatic hemangioma: impact on transplant avoidance: a descriptive case series.
  • PURPOSE: To examine the results of the multimodal management of patients with endangering hepatic hemangioma associated with systemic compromise.
  • METHODS: Retrospective descriptive case series of children with endangering hepatic hemangioma managed at our institution between January 1996 and June 2006.
  • RESULTS: Six children (5 females) presented with endangering hepatic hemangioma with systemic effects during the index time period.
  • All patients received medical treatment, and all patients also underwent hepatic embolization, with a median number of procedures of 2 (range, 1-6).
  • Two patients died, one of sepsis and one of progressive liver failure in a child presenting with advanced liver disease owing to neonatal hemochromatosis that was unrecognized at the time.
  • CONCLUSION: Multimodal management of endangering hepatic hemangioma is a strategy that deserves consideration in the management of these patients.
  • Although the strategy requires further evaluation as to its safety and efficacy, the procedure has the potential to decrease the need for liver transplantation because of treatment failures in this population.
  • [MeSH-major] Adrenal Cortex Hormones / therapeutic use. Embolization, Therapeutic / methods. Hemangioma / therapy. Liver Neoplasms / therapy. Vincristine / therapeutic use
  • [MeSH-minor] Combined Modality Therapy. Female. Follow-Up Studies. Humans. Infant. Infant, Newborn. Liver Transplantation. Male. Retrospective Studies. Risk Assessment. Sampling Studies. Severity of Illness Index. Survival Rate. Treatment Outcome

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  • (PMID = 18206468.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adrenal Cortex Hormones; 5J49Q6B70F / Vincristine
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74. Christison-Lagay ER, Burrows PE, Alomari A, Dubois J, Kozakewich HP, Lane TS, Paltiel HJ, Klement G, Mulliken JB, Fishman SJ: Hepatic hemangiomas: subtype classification and development of a clinical practice algorithm and registry. J Pediatr Surg; 2007 Jan;42(1):62-7; discussion 67-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hepatic hemangiomas: subtype classification and development of a clinical practice algorithm and registry.
  • PURPOSE: Hepatic hemangiomas, though histologically benign, may be associated with significant morbidity and mortality in afflicted infants.
  • The literature presents much confusion regarding the natural history and treatment options for hepatic hemangiomas.
  • Clinical manifestations range from asymptomatic self-limiting lesions to congestive heart failure associated with high-volume vascular shunting to fulminant hepatic failure with hypothyroidism, abdominal compartment syndrome, and death.
  • There has been little rationale to choose among observation, corticosteroid, other pharmacologic agents, arterial embolization, hepatic artery ligation, resection, or liver transplantation for any given patient.
  • METHODS: We analyzed several recent retrospective radiologic analyses and pathologic studies to determine whether hepatic hemangiomas could be categorized, allowing prediction of their natural history and rational choice of therapies based upon their clinical presentation and radiographic appearance.
  • RESULTS: We propose that hepatic hemangiomas do not represent a single entity but, rather, 3 principle categories of lesions: focal, multifocal, and diffuse.
  • With input from international multidisciplinary authorities on hemangiomas, we developed and proposed a clinical practice algorithm for the evaluation and management of hepatic hemangiomas.
  • Toward that end, we propose a plan to institute a web-based international hepatic hemangioma registry.
  • [MeSH-major] Hemangioma / classification. Liver Neoplasms / classification

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  • (PMID = 17208542.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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75. Vossen JA, Buijs M, Liapi E, Eng J, Bluemke DA, Kamel IR: Receiver operating characteristic analysis of diffusion-weighted magnetic resonance imaging in differentiating hepatic hemangioma from other hypervascular liver lesions. J Comput Assist Tomogr; 2008 Sep-Oct;32(5):750-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Receiver operating characteristic analysis of diffusion-weighted magnetic resonance imaging in differentiating hepatic hemangioma from other hypervascular liver lesions.
  • PURPOSE: To evaluate the role of diffusion-weighted imaging in differentiating between hepatic hemangiomas, both typical and atypical, and other hypervascular liver lesions.
  • METHODS: Retrospective review of 182 hypervascular liver lesions in 117 patients was performed.
  • Receiver operating characteristic analysis was used to determine the accuracy of diffusion-weighted imaging in differentiating hemangiomas from other hypervascular liver lesions.
  • RESULTS: Lesions included typical and atypical hemangioma (n = 38), hepatocellular carcinoma (HCC; n = 58), focal nodular hyperplasia (FNH; n = 22), and neuroendocrine tumor metastasis (NET; n = 64) with a mean tumor size of 5.3 cm.
  • Mean ADC value for hemangioma, HCC, FNH, and NET was 2.29 x 10(-3), 1.55 x 10(-3), 1.65 x 10(-3), and 1.43 x 10(-3) mm2/s, respectively.
  • There was a statistically significant difference in the ADC value of hemangioma compared with that of FNH (P < 0.001), HCC (P < 0.001), and NET (P < 0.001), respectively.
  • CONCLUSIONS: Diffusion-weighted magnetic resonance imaging and ADC maps can provide rapid quantifiable information to differentiate typical and atypical hemangiomas from other hypervascular liver lesions.

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  • (PMID = 18830105.001).
  • [ISSN] 1532-3145
  • [Journal-full-title] Journal of computer assisted tomography
  • [ISO-abbreviation] J Comput Assist Tomogr
  • [Language] ENG
  • [Grant] United States / NIBIB NIH HHS / EB / EB006351-03; United States / NIBIB NIH HHS / EB / T32 EB006351; United States / NIBIB NIH HHS / EB / T32 EB006351-03
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS139195; NLM/ PMC2760589
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76. Jr MA, Papaiordanou F, Gonçalves JM, Chaib E: Spontaneous rupture of hepatic hemangiomas: A review of the literature. World J Hepatol; 2010 Dec 27;2(12):428-33

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spontaneous rupture of hepatic hemangiomas: A review of the literature.
  • Hepatic hemangiomas are congenital vascular malformations, considered the most common benign mesenchymal hepatic tumors, composed of masses of blood vessels that are atypical or irregular in arrangement and size.
  • Hepatic hemangiomas can be divided into two major groups: capillary hemangiomas and cavernous hemangiomas These tumors most frequently affect females (80%) and adults in their fourth and fifth decades of life.
  • As the size of the hemangioma increases, so does the chance of rupture.
  • Imaging studies used in the diagnosis of hepatic hemangiomas include ultrasonography, dynamic contrast-enchanced computed tomography scanning, magnetic resonance imaging, hepatic arteriography, digital subtraction angiography, and nuclear medicine studies.
  • In most cases hepatic hemangiomas are asymptomatic and should be followed up by means of periodic radiological examination.
  • In a patient presenting with acute abdominal pain due to unknown abdominal disease, spontaneous rupture of a hepatic tumor such as a hemangioma should be considered as a rare differential diagnosis.

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  • (PMID = 21191518.001).
  • [ISSN] 1948-5182
  • [Journal-full-title] World journal of hepatology
  • [ISO-abbreviation] World J Hepatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC3010512
  • [Keywords] NOTNLM ; Giant hepatic hemangioma / Hepatic hemangioma / Liver tumor / Spontaneous rupture / Surgery
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77. Hansen T, Habekost M, Flieger D, Kirkpatrick CJ: [Littoral cell angioma of the spleen. Association with colon and hepatocellular carcinoma]. Pathologe; 2010 Jul;31(4):290-2
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  • [Title] [Littoral cell angioma of the spleen. Association with colon and hepatocellular carcinoma].
  • [Transliterated title] Littoralzellangiom der Milz. Assoziation mit Kolon- und hepatozellulärem Karzinom.
  • Littoral cell angioma is a rare vascular tumor of the spleen.
  • Due to the relationship with malignant tumors littoral cell angioma should be considered in every case of a splenic tumoral space-occupying mass, particularly in carcinoma patients.
  • [MeSH-major] Adenocarcinoma / pathology. Carcinoma, Hepatocellular / pathology. Colonic Neoplasms / pathology. Hemangioma / pathology. Liver Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Splenic Neoplasms / pathology
  • [MeSH-minor] Aged. Antigens, CD / analysis. Antigens, CD31 / analysis. Antigens, Differentiation, Myelomonocytic / analysis. Biomarkers, Tumor / analysis. Colectomy. Colon / pathology. Hepatectomy. Humans. Liver / pathology. Male. Neoplasm Staging. Spleen / pathology. Splenectomy

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  • (PMID = 20349061.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD31; 0 / Antigens, Differentiation, Myelomonocytic; 0 / Biomarkers, Tumor; 0 / CD68 antigen, human
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78. Herman P, Costa ML, Machado MA, Pugliese V, D'Albuquerque LA, Machado MC, Gama-Rodrigues JJ, Saad WA: Management of hepatic hemangiomas: a 14-year experience. J Gastrointest Surg; 2005 Jul-Aug;9(6):853-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Management of hepatic hemangiomas: a 14-year experience.
  • Hemangioma is the most common primary tumor of the liver and its diagnosis has become increasingly prevalent.
  • Large hemangiomas are often symptomatic and reports of surgical intervention are becoming increasingly frequent.
  • We present our experience, over the last 14 years, with diagnosis and management of 249 liver hemangiomas, with special attention to a conservative strategy.
  • Clinical presentation, diagnosis, treatment, and long-term outcome are analyzed.
  • Diagnosis was based on a radiologic algorithm according to the size and characteristics of the tumor; diagnosis by this method was not possible in only one case (0.4 %).
  • Giant hemangiomas (>4 cm) were found in 68 patients (27.3%) and in 16 were larger than 10 cm.
  • Patients who did not undergo surgery (n = 241) did not present any complication related to the hemangioma during long-term follow-up (mean = 78 months).
  • Hemangioma is a benign course disease with easy diagnosis and management.
  • [MeSH-major] Hemangioma / pathology. Hemangioma / surgery. Liver Neoplasms / pathology. Liver Neoplasms / surgery

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  • (PMID = 15985244.001).
  • [ISSN] 1091-255X
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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79. Santos Rodrigues AL, Silva Santana AC, Carvalho Araújo K, Crociati Meguins L, Felgueiras Rolo D, Pereira Ferreira M: Spontaneous rupture of giant hepatic hemangioma: a rare source of hemoperitoneum. Case report. G Chir; 2010 Mar;31(3):83-5
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  • [Title] Spontaneous rupture of giant hepatic hemangioma: a rare source of hemoperitoneum. Case report.
  • BACKGROUND: Hemoperitoneum due to spontaneous rupture of a hepatic hemangioma is a rare and serious clinical event with a high mortality rate.
  • Computed tomography of the abdomen without oral and venous contrast showed a heterogeneous and capsulated tumor of the liver.
  • Exploratory laparotomy was carried out that revealed a large tumor occupying the gastro-hepatic site with partial rupture of the tumor's capsule with bleeding.
  • Because of the close relationship between the tumor and the retro-hepatic inferior vena cava, the partial resection of the tumor was realized.
  • The study of the tumor revealed hepatic hemangioma.
  • CONCLUSION: Hepatic Hemangiomas may evolve to spontaneous rupture leading to hemorrhagic acute abdomen.
  • Surgery is mandatory and the resection of the Hemangioma will depend on the clinical condition of the patient and on the relationship of the tumor with the vascular structures of the liver.
  • [MeSH-major] Hemangioma, Cavernous / diagnosis. Hemoperitoneum / etiology. Hemoperitoneum / surgery. Hepatectomy / methods. Liver Neoplasms / diagnosis. Pregnancy Complications, Neoplastic / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Pregnancy. Rupture, Spontaneous. Treatment Outcome

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  • (PMID = 20426917.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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80. Da Ines D, Petitcolin V, Lannareix V, Montoriol P, Joubert Zakeyh J, Boyer L, Garcier J: [Liver capsule retraction adjacent to a circumscribed liver lesion: review of 26 cases with histological confirmation]. J Radiol; 2009 Sep;90(9 Pt 1):1067-74
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  • [Title] [Liver capsule retraction adjacent to a circumscribed liver lesion: review of 26 cases with histological confirmation].
  • [Transliterated title] Rétraction capsulaire hépatique en regard d'une lésion circonscrite: à propos de 26 patients avec preuve histologique.
  • PURPOSE: To review the histological features of 26 circumscribed liver lesions associated with liver capsule retraction and discuss the differential diagnosis while evaluating for the presence of fibrous stromal reaction.
  • Retrospective study performed between January 2005 and June 2008 including 26 patients: 18 males and 6 females, without history of cancer, aged between 42 and 82 years (mean age: 64.5 years), presenting with liver capsule retraction adjacent to a circumscribed liver lesion detected on CT or MRI.
  • All liver lesions were biopsied with semi-quantitative evaluation of fibrous stromal reaction.
  • RESULTS: Twenty-one patients had benign or malignant liver tumors and 5 patients had confluent hepatic fibrosis.
  • Twenty of 21 liver tumors were malignant (95.2%): 3 intra-hepatic cholangiocarcinoma, 17 cases of metastatic disease including colorectal carcinoma (n=8), bronchogenic carcinoma (n=1), pancreatic carcinoma (n=4), esophageal carcinoma (n=1), breast carcinoma (n=1), gallbladder carcinoma (1) and endocrine neoplasm of the pancreas (n=1), and 1 case of liver sclerosing angioma (n=1).
  • Excluding the 5 cases of confluent hepatic fibrosis, fibrous stromal reaction was present in 15 of 21 cases.
  • CONCLUSION: The presence of capsular retraction next to a circumscribed liver lesion, while non-specific, is suspicious.
  • [MeSH-major] Liver Neoplasms / pathology

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  • [CommentIn] J Radiol. 2009 Sep;90(9 Pt 1):1019-20 [19752803.001]
  • (PMID = 19752810.001).
  • [ISSN] 0221-0363
  • [Journal-full-title] Journal de radiologie
  • [ISO-abbreviation] J Radiol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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81. Hosokawa A, Maeda T, Tateishi U, Satake M, Iwata R, Ojima H, Arai Y: Hepatic hemangioma presenting atypical radiologic findings: a case report. Radiat Med; 2005 Aug;23(5):371-5
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  • [Title] Hepatic hemangioma presenting atypical radiologic findings: a case report.
  • A 69-year-old woman was referred to our hospital due to a liver tumor that was incidentally noted on ultrasound (US).
  • On post-gadolinium hepatic arterial dominant-phase MR images, the tumor showed nodular enhancement centrally, with progressive spread of enhancement on later images.
  • Angiography showed dilatation of the right posterior inferior branch of the hepatic artery and C-shaped opacification.
  • Since we could not rule out malignancy for these nonspecific radiologic findings, a partial resection of the liver was carried out, resulting in a pathological diagnosis of hepatic hemangioma.
  • This hemangioma had marked hyalinization and fibrosis, causing a heterogeneous appearance on MR images.
  • [MeSH-major] Hemangioma / diagnosis. Liver / radiography. Liver Neoplasms / diagnosis
  • [MeSH-minor] Aged. Contrast Media / administration & dosage. Diagnosis, Differential. Female. Humans. Image Enhancement / methods. Magnetic Resonance Imaging / methods. Tomography, X-Ray Computed / methods

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  • (PMID = 16342910.001).
  • [ISSN] 0288-2043
  • [Journal-full-title] Radiation medicine
  • [ISO-abbreviation] Radiat Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Contrast Media
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82. Jain V, Ramachandran V, Garg R, Pal S, Gamanagatti SR, Srivastava DN: Spontaneous rupture of a giant hepatic hemangioma - sequential management with transcatheter arterial embolization and resection. Saudi J Gastroenterol; 2010 Apr-Jun;16(2):116-9
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  • [Title] Spontaneous rupture of a giant hepatic hemangioma - sequential management with transcatheter arterial embolization and resection.
  • Hemangioma is the most common benign tumor of liver and is often asymptomatic.
  • Emergent hepatic resection has been the treatment of choice but has high operative mortality.
  • We report a case of spontaneous rupture of giant hepatic hemangioma that presented with abdominal pain and shock due to hemoperitoneum.
  • TAE is an effective procedure in symptomatic hemangiomas, and should be considered in such high risk patients prior to surgery.
  • [MeSH-major] Embolization, Therapeutic / methods. Hemangioma, Cavernous / therapy. Hemoperitoneum / therapy. Hepatectomy / methods. Liver Neoplasms / therapy
  • [MeSH-minor] Abdominal Pain / diagnosis. Abdominal Pain / etiology. Adult. Combined Modality Therapy. Follow-Up Studies. Humans. Male. Risk Assessment. Rupture, Spontaneous. Severity of Illness Index. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 20339183.001).
  • [ISSN] 1998-4049
  • [Journal-full-title] Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association
  • [ISO-abbreviation] Saudi J Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Saudi Arabia
  • [Other-IDs] NLM/ PMC3016500
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83. Lanthaler M, Freund M, Nehoda H: Laparoscopic resection of a giant liver hemangioma. J Laparoendosc Adv Surg Tech A; 2005 Dec;15(6):624-6
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  • [Title] Laparoscopic resection of a giant liver hemangioma.
  • We present a case report of hepatic resection performed laparoscopically for a giant symptomatic hemangioma.
  • The patient was a 50-year-old woman who was diagnosed with a giant hemangioma 20 cm in diameter.
  • As in the case of our patient, laparoscopic resection of hepatic hemangiomas can be performed successfully, even when dealing with giant hemangiomas.
  • [MeSH-major] Hemangioma / surgery. Laparoscopy / methods. Liver Neoplasms / surgery

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  • (PMID = 16366871.001).
  • [ISSN] 1092-6429
  • [Journal-full-title] Journal of laparoendoscopic & advanced surgical techniques. Part A
  • [ISO-abbreviation] J Laparoendosc Adv Surg Tech A
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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84. Pulvirenti E, Toro A, Di Carlo I: An update on indications for treatment of solid hepatic neoplasms in noncirrhotic liver. Future Oncol; 2010 Aug;6(8):1243-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An update on indications for treatment of solid hepatic neoplasms in noncirrhotic liver.
  • During recent years, we have experienced an increased detection of previously unsuspected liver masses in otherwise asymptomatic patients owing to the widespread application of imaging techniques.
  • Regardless of the malignant or cystic tissues, a remarkable percentage of these masses are represented by benign solid neoplasms.
  • Treatment of benign liver tumors still represents a major concern in the hepatic surgery field.
  • In this article, the main surgical indication for hepatic hemangioma, focal nodular hyperplasia and hepatocellular adenoma are discussed with regard to the most recent advancements in literature.
  • In addition, a separate section deals with the role of laparoscopy in the treatment of benign liver neoplasms.
  • [MeSH-major] Carcinoma, Hepatocellular / surgery. Cysts / surgery. Focal Nodular Hyperplasia / surgery. Hemangioma / surgery. Liver Neoplasms / surgery

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  • (PMID = 20799871.001).
  • [ISSN] 1744-8301
  • [Journal-full-title] Future oncology (London, England)
  • [ISO-abbreviation] Future Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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85. Fan RF, Chai FL, He GX, Wan WX, Bai MD, Cao ML, Li HM, Yan SZ: [Radiofrequency ablation therapy combined with suture and ligation surgery for patients with giant cavernous hemangiomas of the liver]. Zhonghua Yi Xue Za Zhi; 2006 Aug 15;86(30):2134-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Radiofrequency ablation therapy combined with suture and ligation surgery for patients with giant cavernous hemangiomas of the liver].
  • OBJECTIVE: To evaluate the feasibility and efficacy of radiofrequency ablation (RFA) therapy combined with suture and ligation surgery for patients with giant hepatic cavernous hemangioma (HCH).
  • METHODS: Between June 2004 and June 2005, a total of 30 patients were treated by RFA therapy after suture and ligation surgery (SL group, n = 15, with 18 liver lesions) or RFA therapy without suture and ligation surgery (non-SL group, n = 15, with 17 liver lesions) under general anesthesia.
  • Preoperative diagnosis of HCH was established by means of ultrasonography, helical computed tomography (CT) scans, and magnetic resonance imaging (MRI).
  • All of the 35 lesions were located on the liver surface, in the caudate lobe of the liver, or adjacent to the gallbladder.
  • Cholecystectomy was performed simultaneously for gallstones in 7 patients and for abutting of gallbladder from hemangioma in 2 patients.
  • [MeSH-major] Catheter Ablation. Hemangioma, Cavernous / surgery. Liver Neoplasms / surgery

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  • (PMID = 17064621.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Randomized Controlled Trial
  • [Publication-country] China
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86. Seitz K, Bernatik T, Strobel D, Blank W, Friedrich-Rust M, Strunk H, Greis C, Kratzer W, Schuler A: Contrast-enhanced ultrasound (CEUS) for the characterization of focal liver lesions in clinical practice (DEGUM Multicenter Trial): CEUS vs. MRI--a prospective comparison in 269 patients. Ultraschall Med; 2010 Oct;31(5):492-9
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  • [Title] Contrast-enhanced ultrasound (CEUS) for the characterization of focal liver lesions in clinical practice (DEGUM Multicenter Trial): CEUS vs. MRI--a prospective comparison in 269 patients.
  • PURPOSE: The aim of this prospective multicenter study was to assess the diagnostic role of CEUS in the diagnosis of newly discovered focal liver lesions in clinical practice.
  • MATERIALS AND METHODS: From 05 / 2004 to 12 / 2006, standardized CEUS was performed prospectively on 1349 patients with focal liver lesions that had been newly detected by fundamental ultrasound in order to determine tumor differentiation and tumor entity.
  • In typical liver hemangioma and focal nodular hyperplasia (FNH), the definitive diagnosis was based on the MRI as the "diagnostic gold standard" and on clinical evidence and additional follow-up (subgroup A) or on histology (subgroup B).
  • RESULTS: In the subcollective (n = 262), the tumor differentiation (malignant or benign) of CEUS and MRI was concordant in 225 cases (85.9%), and the assessment of tumor entity in 204 cases (77.9%).
  • Liver hemangiomas (n = 122) and FNH (n = 43) were most frequent.
  • Subgroup B (n = 82) comprised mainly malignant liver lesions (n = 55), with only a few of hemangiomas (n = 8) or FNH (n = 5).
  • CONCLUSION: CEUS and MRI are of equal value for the differentiation and specification of newly discovered liver tumors in clinical practice.
  • CEUS and MRI are extremely reliable for the differentiation of benign and malignant lesions, the diagnosis of liver hemangiomas and FNH.
  • [MeSH-major] Carcinoma, Hepatocellular / diagnosis. Focal Nodular Hyperplasia / diagnosis. Hemangioma / diagnosis. Image Enhancement. Image Processing, Computer-Assisted. Liver Neoplasms / diagnosis. Liver Neoplasms / secondary. Magnetic Resonance Imaging. Ultrasonography
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Cohort Studies. Contrast Media / administration & dosage. Dextrans. Diagnosis, Differential. Female. Gadolinium. Gadolinium DTPA. Heterocyclic Compounds. Humans. Liver / pathology. Liver Cirrhosis / diagnosis. Liver Cirrhosis / pathology. Magnetite Nanoparticles. Male. Middle Aged. Organometallic Compounds. Phospholipids. Prospective Studies. Sensitivity and Specificity. Software. Sulfur Hexafluoride. Young Adult

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  • [Copyright] © Georg Thieme Verlag KG Stuttgart · New York.
  • (PMID = 20652854.001).
  • [ISSN] 1438-8782
  • [Journal-full-title] Ultraschall in der Medizin (Stuttgart, Germany : 1980)
  • [ISO-abbreviation] Ultraschall Med
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Heterocyclic Compounds; 0 / Magnetite Nanoparticles; 0 / Organometallic Compounds; 0 / Phospholipids; 0 / contrast agent BR1; 0199MV609F / gadoteridol; AU0V1LM3JT / Gadolinium; G6N3J05W84 / ferumoxides; K2I13DR72L / Gadolinium DTPA; K3R6ZDH4DU / Dextrans; WS7LR3I1D6 / Sulfur Hexafluoride
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87. Corsale I, Buccianelli E, Rigutini M, Mori P, Bartolomei M, Aloise F, Sorce S, Veltroni A: [Liver haemangioma: current surgical indications. Our experience]. G Chir; 2005 Apr;26(4):153-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Liver haemangioma: current surgical indications. Our experience].
  • Hemangiomas are the more frequent benign liver tumours.
  • Therapeutic approach at these neoplasms is changed in the last years because has resulted that massive haemoperitoneum from a spontaneous rupture of the hemangiomas is a rare occurrence.
  • From a personal review of 124 liver resection performed for traumatic and organic, benign and malignant, pathologies, the Authors present two cases of symptomatic liver haemangioma surgically treated Excluding emergency induced by tumour hemorrhage, actually indications to surgical treatment are controversial.
  • In all patients the right approach is choice by the integrated evaluation of general conditions of the patient, liver functionality and from anatomical location of the neoplasm.
  • [MeSH-major] Hemangioma / surgery. Hepatectomy / standards. Liver Neoplasms / surgery

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  • (PMID = 16035251.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
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88. Wananukul S, Voramethkul W, Nuchprayoon I, Seksarn P: Diffuse Neonatal Hemangiomatosis: report of 5 cases. J Med Assoc Thai; 2006 Aug;89(8):1297-303
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  • Diffuse Neonatal Hemangiomatosis (DNH) is a rare, life-threatening condition associated with a few to hundreds of small, cutaneous and visceral hemangiomas.
  • The authors reported 5 cases of DNH in which hepatic hemangioma were the most common visceral involvement.
  • [MeSH-major] Angiomatosis / diagnosis. Angiomatosis / drug therapy. Antineoplastic Agents, Hormonal / therapeutic use. Antineoplastic Agents, Phytogenic / therapeutic use. Hemangioma / diagnosis. Hemangioma / drug therapy. Liver Neoplasms / diagnosis. Liver Neoplasms / drug therapy. Prednisolone / therapeutic use. Skin Neoplasms / diagnosis. Skin Neoplasms / drug therapy. Vinblastine / therapeutic use

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  • (PMID = 17048444.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Thailand
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Hormonal; 0 / Antineoplastic Agents, Phytogenic; 5V9KLZ54CY / Vinblastine; 9PHQ9Y1OLM / Prednisolone
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89. Ocama P, Katwere M, Piloya T, Feld J, Opio KC, Kambugu A, Katabira E, Thomas D, Colebunders R, Ronald A: The spectrum of liver diseases in HIV infected individuals at an HIV treatment clinic in Kampala, Uganda. Afr Health Sci; 2008 Mar;8(1):8-12
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  • [Title] The spectrum of liver diseases in HIV infected individuals at an HIV treatment clinic in Kampala, Uganda.
  • BACKGROUND: Liver diseases are common in patients with HIV due to viral hepatitis B and C co-infections, opportunistic infections or malignancies, antiretroviral drugs and drugs for opportunistic infections.
  • OBJECTIVE: To describe the spectrum of liver diseases in HIV-infected patients attending an HIV clinic in Kampala, Uganda.
  • METHOD: Consecutive patients presenting with jaundice, right upper quadrant pain with fever or malaise, ascites and/or tender hepatomegaly were recruited and underwent investigations to evaluate the cause of their liver disease.
  • Although 14 (61%) patients with drug-induced liver disease presented with jaundice, all recovered with drug discontinuation.
  • Other diagnoses included alcoholic liver disease, AIDS cholangiopathy, hepatocellular carcinoma, schistosomiasis, haemangioma and hepatic adenoma.
  • Twelve (16%) patients died during follow-up of which 7 (9%) died because of liver disease.
  • CONCLUSION: Drug history, liver enzyme studies, ultrasound, and hepatitis B and C investigations identified the probable etiology in 60 (78%) of 77 patients with HIV infection presenting with symptoms and/or signs of liver disease.
  • [MeSH-major] Anti-HIV Agents / adverse effects. Antitubercular Agents / adverse effects. HIV Infections / complications. HIV Infections / drug therapy. Isoniazid / adverse effects. Liver Diseases / epidemiology. Nevirapine / adverse effects. Reverse Transcriptase Inhibitors / adverse effects
  • [MeSH-minor] Comorbidity. Drug-Induced Liver Injury. Female. Follow-Up Studies. Humans. Immunocompromised Host. Incidence. Liver Neoplasms / epidemiology. Male. Prevalence. Time Factors. Treatment Outcome. Tuberculosis / drug therapy. Tuberculosis / epidemiology. Uganda

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  • (PMID = 19357726.001).
  • [ISSN] 1729-0503
  • [Journal-full-title] African health sciences
  • [ISO-abbreviation] Afr Health Sci
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Uganda
  • [Chemical-registry-number] 0 / Anti-HIV Agents; 0 / Antitubercular Agents; 0 / Reverse Transcriptase Inhibitors; 99DK7FVK1H / Nevirapine; V83O1VOZ8L / Isoniazid
  • [Other-IDs] NLM/ PMC2408539
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90. Feuerlein S, Pauls S, Juchems MS, Stuber T, Hoffmann MH, Brambs HJ, Ernst AS: Pitfalls in abdominal diffusion-weighted imaging: how predictive is restricted water diffusion for malignancy. AJR Am J Roentgenol; 2009 Oct;193(4):1070-6
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  • The aim of our retrospective study was to investigate the specificity of restricted diffusion in differentiation of benign from malignant abdominal disease.
  • The 12 benign lesions were liver hemangioma, liver adenoma, autoimmune pancreatitis, pancreatic teratoma, two abscesses, three cases of inflammatory bowel wall thickening due to Crohn's disease, Bartholin cyst, hemorrhagic ovarian cyst, and renal Rosai-Dorfman disease.
  • However, in interpretation of diffusion-weighted images, it should be kept in mind that a number of benign lesions, as many as 22% in our cohort, can exhibit restricted diffusion on images with high b values, thus mimicking malignant lesions.
  • [MeSH-major] Abdominal Neoplasms / diagnosis. Artifacts. Diffusion Magnetic Resonance Imaging / methods

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  • (PMID = 19770331.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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91. Kim EH, Park SY, Ihn YK, Hwang SS: Diffuse hepatic hemangiomatosis without extrahepatic involvement in an adult patient. Korean J Radiol; 2008 Nov-Dec;9(6):559-62
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  • [Title] Diffuse hepatic hemangiomatosis without extrahepatic involvement in an adult patient.
  • We report an extremely rare case of a diffuse hepatic hemangiomatosis without extrahepatic involvement in an adult.
  • The imaging findings of this tumor were similar to those of a hepatic hemangioma and included contrast enhancement with a centripetal filling pattern of the entire hepatic tumor on the delayed phase of a dynamic CT and inhomogeneous diffuse uptake of the entire tumor on blood-pool images obtained five hours later on a 99mTc-labeled red blood cell scan.
  • Despite its rarity, diffuse hepatic hemangiomatosis can be suggested in adult patients with diffusely involved hepatic tumors showing the radiological findings of a hepatic hemangioma.
  • [MeSH-major] Hemangioma / diagnosis. Liver Neoplasms / diagnosis

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  • (PMID = 19039274.001).
  • [ISSN] 1229-6929
  • [Journal-full-title] Korean journal of radiology
  • [ISO-abbreviation] Korean J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2627242
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92. Chen RC, Lii JM, Chen WT, Tu HY, Chiang LC: Transcatheter arterial chemoembolization in patients with hepatocellular carcinoma and coexisting hepatic cavernous hemangioma. Eur Radiol; 2006 Jun;16(6):1346-50
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  • [Title] Transcatheter arterial chemoembolization in patients with hepatocellular carcinoma and coexisting hepatic cavernous hemangioma.
  • We investigated the consequence of repeated transcatheter arterial chemoembolization (TACE) for coexisting small hepatic hemangioma in the treatment of patients with hepatocellular carcinomas and describe the imaging features of embolized hemangioma on the follow-up Lipiodol CT and MR.
  • Six of 431 patients with biopsy-confirmed hepatocellular carcinomas, who underwent TACE, also had seven small hepatic cavernous hemangiomas (0.8 approximately 2.3 cm) in the same area of embolization.
  • The outcomes and imaging features of these embolized hemangiomas were reviewed for the change of tumor size, Lipiodol deposition, enhancing pattern as well as embolization complications.
  • Six of the seven hemangiomas did not depict changes in the size or enhancement pattern without being ablated.
  • One hemangioma showed a decrease in size, but still persisted after TACE.
  • All of the hemangiomas showed Lipiodol deposition for 2 approximately 15 months, in which five hemangiomas depicted irregular rim patterns.
  • The differentiation of small hepatic hemangiomas from viable HCC is important in the post-TACE follow-up to avoid unnecessary repeated embolization.
  • [MeSH-major] Carcinoma, Hepatocellular / therapy. Chemoembolization, Therapeutic / methods. Hemangioma, Cavernous / therapy. Liver Neoplasms / therapy. Neoplasms, Multiple Primary / therapy

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  • (PMID = 16331460.001).
  • [ISSN] 0938-7994
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Contrast Media; 3Z8479ZZ5X / Epirubicin; 50SG953SK6 / Mitomycin; 8001-40-9 / Iodized Oil
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93. Wang J, Pei G, Yan J, Zhang G: Coexistence of a giant splenic hemangioma and multiple hepatic hemangiomas mimicking a left adrenal neuroblastoma accompanied with multifocal hepatic metastases: pyrite answer. J Pediatr Hematol Oncol; 2009 Dec;31(12):983-4
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  • [Title] Coexistence of a giant splenic hemangioma and multiple hepatic hemangiomas mimicking a left adrenal neuroblastoma accompanied with multifocal hepatic metastases: pyrite answer.
  • A 4-month girl presenting with a giant mass in left adrenal region and multiple hepatic nodules was hospitalized.
  • On the basis of computed tomography, ultrasound and epidemiology we preferred the diagnosis of a left adrenal neuroblastoma accompanied with multiple hepatic metastases preoperatively.
  • But postoperative diagnosis was hemangiomatosis characterized by synchronous presence of a giant splenic hemangioma and multiple hepatic hemangiomas.
  • We think that it is deservedly reported because of not only its rarity but also pitfalls of preoperative differential diagnosis and management principle.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Hemangioma / pathology. Liver Neoplasms / pathology. Neoplasms, Second Primary / pathology. Neuroblastoma / diagnosis. Splenic Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Infant. Magnetic Resonance Imaging. Tomography, X-Ray Computed. Ultrasonography


94. Finlay GA, Malhowski AJ, Polizzi K, Malinowska-Kolodziej I, Kwiatkowski DJ: Renal and liver tumors in Tsc2(+/-) mice, a model of tuberous sclerosis complex, do not respond to treatment with atorvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor. Mol Cancer Ther; 2009 Jul;8(7):1799-807
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  • [Title] Renal and liver tumors in Tsc2(+/-) mice, a model of tuberous sclerosis complex, do not respond to treatment with atorvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor.
  • We tested atorvastatin as a therapy for (a) ethylnitrosourea (ENU)-enhanced renal cystadenoma and (b) spontaneous liver hemangioma in 129Sv/Jae Tsc2(+/-) mice.
  • Pathologic analyses revealed a predominance of renal cystadenoma in ENU-treated and liver hemangioma in non-ENU-treated 129Sv/Jae Tsc2(+/-) mice.
  • Following atorvastatin treatment, no significant reduction in tumor size, morphology, or phosphorylated S6 levels was observed for either ENU-associated renal cystadenoma or spontaneous liver hemangioma as compared with the untreated groups.

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  • (PMID = 19584242.001).
  • [ISSN] 1538-8514
  • [Journal-full-title] Molecular cancer therapeutics
  • [ISO-abbreviation] Mol. Cancer Ther.
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / K08 HL074113; United States / NHLBI NIH HHS / HL / K08 HL074113-03; United States / NCI NIH HHS / CA / P01 CA120964; United States / NHLBI NIH HHS / HL / K08 HL074113-05; United States / NHLBI NIH HHS / HL / HL074113-05
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Heptanoic Acids; 0 / Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0 / Pyrroles; 0 / Tumor Suppressor Proteins; 48A5M73Z4Q / Atorvastatin Calcium; 4JG2LF96VF / tuberous sclerosis complex 2 protein; 97C5T2UQ7J / Cholesterol
  • [Other-IDs] NLM/ NIHMS119618; NLM/ PMC2712945
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95. Sampol Bas C, Peña Viloria C: [Uptake of 123I-MIBG in a hepatic hemangioma in the scintigraphic study of an adrenal gland lesion]. Rev Esp Med Nucl; 2005 May-Jun;24(3):191-4
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  • [Title] [Uptake of 123I-MIBG in a hepatic hemangioma in the scintigraphic study of an adrenal gland lesion].
  • [Transliterated title] Captación de 123I-MIBG en un hemangioma hepático en el estudio gammagráfico de una lesión suprarrenal.
  • MRI confirmed the presence of a mass in the left adrenal gland suggestive of an adenoma and found a lesion in the right hepatic area at the level of the previously seen MIBG image.
  • This lesion was labelled as a hemangioma and would explain the findings of the isotopic study with MIBG.
  • [MeSH-major] 3-Iodobenzylguanidine. Adrenal Glands / radiography. Diagnostic Errors. Hemangioma / radionuclide imaging. Iodine Radioisotopes. Liver Neoplasms / radionuclide imaging
  • [MeSH-minor] Adenoma / diagnosis. Adrenal Gland Neoplasms / diagnosis. Adrenergic Uptake Inhibitors / adverse effects. Adrenergic Uptake Inhibitors / pharmacology. Adrenergic Uptake Inhibitors / therapeutic use. Antidepressive Agents / adverse effects. Antidepressive Agents / pharmacology. Antidepressive Agents / therapeutic use. Antipsychotic Agents / adverse effects. Antipsychotic Agents / pharmacology. Antipsychotic Agents / therapeutic use. Catecholamines / blood. Diagnosis, Differential. Drug Interactions. False Positive Reactions. Female. Fibula / injuries. Fibula / radiography. Fractures, Bone / complications. Fractures, Bone / radiography. Humans. Incidental Findings. Magnetic Resonance Imaging. Middle Aged. Pheochromocytoma / diagnosis. Psychotic Disorders / complications. Psychotic Disorders / drug therapy. Tibial Fractures / complications. Tibial Fractures / radiography. Tomography, X-Ray Computed

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  • (PMID = 15847786.001).
  • [ISSN] 0212-6982
  • [Journal-full-title] Revista española de medicina nuclear
  • [ISO-abbreviation] Rev Esp Med Nucl
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Adrenergic Uptake Inhibitors; 0 / Antidepressive Agents; 0 / Antipsychotic Agents; 0 / Catecholamines; 0 / Iodine Radioisotopes; 35MRW7B4AD / 3-Iodobenzylguanidine
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96. Dietrich CF, Mertens JC, Braden B, Schuessler G, Ott M, Ignee A: Contrast-enhanced ultrasound of histologically proven liver hemangiomas. Hepatology; 2007 May;45(5):1139-45
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  • [Title] Contrast-enhanced ultrasound of histologically proven liver hemangiomas.
  • Differentiation of small and atypical hemangiomas from other hepatic masses using imaging methods can be difficult, especially in patients with underlying malignant disease.
  • Therefore, contrast-enhanced ultrasound was assessed in patients with histologically confirmed hemangiomas with respect to contrast-enhancing kinetics and tumor characteristics.
  • In 58 patients with indeterminate hepatic lesions demonstrated with at least 2 imaging methods (ultrasound/computed tomography/magnetic resonance imaging), ultrasound-guided liver biopsy revealed hemangioma.
  • In all patients a hepatic neoplasm had been suspected because of underlying malignant disease (n=41), liver cirrhosis (n=15), or growth of the lesion (n=2).
  • Forty-five (78%) of the hemangiomas showed homogenous centripetal filling within 180 seconds.
  • CONCLUSION: Contrast-enhanced ultrasound demonstrates typical hemangioma imaging characteristics, that is, peripheral nodular contrast enhancement and iris-diaphragm sign in a high percentage of patients with undetermined lesions.
  • This technique may therefore improve noninvasive functional characterization and differentiation of hemangiomas.
  • [MeSH-major] Hemangioma / ultrasonography. Liver / ultrasonography. Liver Neoplasms / ultrasonography

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  • (PMID = 17464990.001).
  • [ISSN] 0270-9139
  • [Journal-full-title] Hepatology (Baltimore, Md.)
  • [ISO-abbreviation] Hepatology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Phospholipids; 0 / contrast agent BR1; WS7LR3I1D6 / Sulfur Hexafluoride
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97. Fernandez S, Cook GW, Arber DA: Metastasizing splenic littoral cell hemangioendothelioma. Am J Surg Pathol; 2006 Aug;30(8):1036-40
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  • Littoral cell angioma is a unique splenic tumor that is generally considered to be benign.
  • We present a case of a low-grade littoral cell splenic tumor that metastasized to the liver and retroperitoneum 4 years after splenectomy.
  • Although the splenic lesion showed the typical morphology of a littoral cell angioma, it also contained areas with unusual solid nests of cytologically bland, plump cells with clear cytoplasm.
  • The liver was diffusely infiltrated exclusively by cells with similar clear cell features.
  • Both splenic and liver lesions demonstrated identical immunophenotypes, typical of littoral cell angioma, expressing CD31, CD68, CD21, and CD163, although negative for CD8 and CD34.
  • This case suggests that the presence of solid areas of clear cells in a littoral cell angioma may be a marker of low-grade malignant potential in these tumors.
  • [MeSH-major] Hemangioendothelioma / secondary. Liver Neoplasms / secondary. Retroperitoneal Neoplasms / secondary. Splenic Neoplasms / pathology

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  • (PMID = 16861977.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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98. Xu LN, Huang ZQ: Resection of hepatic caudate lobe hemangioma: experience with 11 patients. Hepatobiliary Pancreat Dis Int; 2010 Oct;9(5):487-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Resection of hepatic caudate lobe hemangioma: experience with 11 patients.
  • BACKGROUND: Caudate lobectomy is now considered to be the most appropriate surgical treatment for benign tumors in the caudate lobe.
  • But how to resect the caudate lobe safely is a major challenge to current liver surgery and requires further study.
  • This research aimed to analyze the perioperative factors and explore the surgical technique associated with liver resection in hepatic caudate lobe hemangioma.
  • METHODS: Eleven consecutive patients with symptomatic hepatic hemangiomas undergoing caudate lobectomy from November 1990 to August 2009 at our hospital were investigated retrospectively.
  • Ascites occurred in l patient, pleural effusion in the perioperative period in 1, and multiple organ failure in l on the 6th day after operation as a result of massive intraoperative blood loss, who had received multiple transcatheter hepatic arterial embolization preoperatively.
  • CONCLUSIONS: For large hemangioma of the caudate lobe, surgery is only recommended for symptomatic cases.
  • Caudate lobectomy of hepatic hemangioma can be performed safely, provided it is carried out with optimized perioperative management and innovative surgical technique.
  • [MeSH-major] Hemangioma / surgery. Hepatectomy / methods. Liver Neoplasms / surgery

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  • (PMID = 20943457.001).
  • [ISSN] 1499-3872
  • [Journal-full-title] Hepatobiliary & pancreatic diseases international : HBPD INT
  • [ISO-abbreviation] HBPD INT
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
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99. Kurimoto M, Noguchi K, Nagai S, Asahi T, Kuwayama N, Hayashi N, Endo S: Thoracic vertebral cavernous hemangioma in a schizophrenic patient--case report. Neurol Med Chir (Tokyo); 2010;50(6):485-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Thoracic vertebral cavernous hemangioma in a schizophrenic patient--case report.
  • Computed tomography (CT) and magnetic resonance imaging suggested thoracic vertebral hemangioma.
  • Dynamic CT incidentally detected a hepatic hemangioma.
  • Laminectomy of T3 and T4, resection of the epidural hemangioma, and rigid instrumentation between T1 and T6 using rod and hook systems were performed.
  • Postoperatively, his symptoms completely disappeared and the histological diagnosis was capillary hemangioma.
  • The patient had a rare association of vertebral hemangioma and hepatic hemangioma, which may be a chance occurrence.
  • [MeSH-major] Hemangioma, Cavernous, Central Nervous System / complications. Hemangioma, Cavernous, Central Nervous System / pathology. Schizophrenia / complications. Spinal Cord Compression / etiology. Spinal Cord Compression / pathology. Thoracic Vertebrae / pathology

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  • (PMID = 20587975.001).
  • [ISSN] 1349-8029
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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100. Sood D, Kumaran V, Buxi TB, Nundy S, Soin AS: Liver hemangioma mimicking cholangiocarcinoma--a diagnostic dilemma. Trop Gastroenterol; 2009 Jan-Mar;30(1):44-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Liver hemangioma mimicking cholangiocarcinoma--a diagnostic dilemma.
  • A 55-year-old man presented with a liver mass that had been diagnosed on ultrasonography, carried out in response to the patient's complaint of non-specific abdominal pain.
  • Triphasic computed tomography (CT) revealed a lesion involving segments 1, 4, 5 and 8 of the liver.
  • The middle hepatic vein was encased and the tumour was present near the junction of the left hepatic and middle hepatic veins.
  • We planned a right hepatic trisegmentectomy including resection of the caudate lobe but since the estimated volume of the liver remnant was only 17% of the total, we first embolised the right portal vein.
  • CT scan repeated 5 weeks later revealed that the lesion was still resectable and that the left lateral segment had hypertrophied to 27% of the liver volume.
  • We performed a right trisegmentectomy including caudate lobe resection using intra-operative ultrasonography to establish that the left hepatic vein was not involved.
  • Histopathological examination revealed a hemangioma.
  • [MeSH-major] Bile Duct Neoplasms / diagnosis. Bile Ducts, Intrahepatic / surgery. Cholangiocarcinoma / diagnosis. Hemangioma / diagnosis. Liver Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Embolization, Therapeutic / methods. Hepatectomy / methods. Humans. Liver / pathology. Liver / radiography. Liver / surgery. Male. Middle Aged. Portal Vein / pathology. Portal Vein / radiography. Portal Vein / surgery. Tomography, X-Ray Computed / methods

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  • (PMID = 19624089.001).
  • [ISSN] 0250-636X
  • [Journal-full-title] Tropical gastroenterology : official journal of the Digestive Diseases Foundation
  • [ISO-abbreviation] Trop Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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