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1. Valbuena JR, Levenback C, Mansfield P, Liu J: Angiosarcoma of the spleen clinically presenting as metastatic ovarian cancer. A case report and review of the literature. Ann Diagn Pathol; 2005 Oct;9(5):289-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Histologically, the tumor is characterized by neoplastic proliferation with diffuse or focal areas of a vasoformative component with cavernous and arborizing channels.
  • The differential diagnosis includes a variety of benign and malignant vascular proliferations (littoral cell angioma and Kaposi's sarcoma) as well as metastatic tumors.
  • The liver is the most common site.
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans


2. Coenegrachts K, Orlent H, ter Beek L, Haspeslagh M, Bipat S, Stoker J, Rigauts H: Improved focal liver lesion detection: comparison of single-shot spin-echo echo-planar and superparamagnetic iron oxide (SPIO)-enhanced MRI. J Magn Reson Imaging; 2008 Jan;27(1):117-24
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Improved focal liver lesion detection: comparison of single-shot spin-echo echo-planar and superparamagnetic iron oxide (SPIO)-enhanced MRI.
  • PURPOSE: To prospectively compare single-shot spin-echo echo-planar imaging (SSSE-EPI) using b = 0, 10, 150, and 400 seconds/mm(2) with standard MRI techniques after intravenous super paramagnetic iron oxide (SPIO) in the detection and characterization of focal liver lesions with focus on small (<10 mm) focal liver lesions.
  • MATERIALS AND METHODS: A total of 25 patients suspected for colorectal liver metastases were included.
  • RESULTS: Reference standard demonstrated 25 hemangiomas and 70 metastases.
  • CONCLUSION: This preliminary study shows the potential of SSSE-EPI as a stand-alone sequence for the detection of liver hemangiomas and metastases when compared with SPIO-enhanced imaging.
  • [MeSH-major] Colorectal Neoplasms / pathology. Contrast Media / administration & dosage. Echo-Planar Imaging / methods. Iron / administration & dosage. Liver Neoplasms / secondary. Magnetic Resonance Imaging / methods. Oxides / administration & dosage

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  • (PMID = 18050350.001).
  • [ISSN] 1053-1807
  • [Journal-full-title] Journal of magnetic resonance imaging : JMRI
  • [ISO-abbreviation] J Magn Reson Imaging
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Magnetite Nanoparticles; 0 / Oxides; E1UOL152H7 / Iron; G6N3J05W84 / ferumoxides; K3R6ZDH4DU / Dextrans; XM0M87F357 / Ferrosoferric Oxide
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3. Haass NK, Wladykowski E, Kief S, Moll I, Brandner JM: Differential induction of connexins 26 and 30 in skin tumors and their adjacent epidermis. J Histochem Cytochem; 2006 Feb;54(2):171-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Further, Cx26 and Cx30 are induced in the epidermis adjacent to malignant melanoma but absent in the epidermis adjacent to benign non-epithelial skin lesions (melanocytic nevi and angioma).
  • [MeSH-minor] Animals. Bowen's Disease / metabolism. Carcinoma, Basal Cell / metabolism. Carcinoma, Squamous Cell / metabolism. Hemangioma / metabolism. Humans. Keratinocytes / metabolism. Keratins / metabolism. Keratosis / metabolism. Liver / metabolism. Melanoma / metabolism. Mice. Mice, Inbred C57BL. Microscopy, Fluorescence. Nevus, Pigmented / metabolism. Warts / metabolism

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  • (PMID = 16046668.001).
  • [ISSN] 0022-1554
  • [Journal-full-title] The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
  • [ISO-abbreviation] J. Histochem. Cytochem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Connexins; 0 / GJB6 protein, human; 127120-53-0 / connexin 26; 68238-35-7 / Keratins
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4. Laverdiere M, Aggarawal R, Blei F: Hemangiomatosis in two sets of premature twins. Am J Perinatol; 2008 May;25(5):295-300
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We attempted to identify the association of multifocal hemangiomas, specifically hepatic hemangiomatosis, in twins.
  • We retrospectively reviewed our database of infants with hemangiomas, identifying those twins who both had hemangiomas, and we report two cases of twins with hemangiomatosis, including hepatic hemangiomas.
  • Of 39 sets of twins in our Hemangioma Program, both twins had hemangiomas in seven twin sets.
  • There were also five sets of triplets, with one set having two siblings affected by hemangiomas.
  • We concluded that although hemangiomas in multiple gestation infants is well known, hemangiomatosis including hepatic hemangiomatosis is unusual.
  • [MeSH-major] Diseases in Twins. Hemangioma / diagnosis. Infant, Premature, Diseases / diagnosis. Liver Neoplasms / diagnosis. Skin Neoplasms / diagnosis


5. Alomari AI: Comments on imaging and management of hepatic hemangiomas. Pediatr Radiol; 2009 Jun;39(6):637-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comments on imaging and management of hepatic hemangiomas.
  • [MeSH-major] Diagnostic Imaging / methods. Hemangioma / diagnosis. Liver Neoplasms / diagnosis

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  • [CommentOn] Pediatr Radiol. 2009 Mar;39(3):277-81 [19083217.001]
  • [Cites] Eur J Pediatr. 2008 Aug;167(8):961-2; author reply 963 [17952463.001]
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  • (PMID = 19387632.001).
  • [ISSN] 1432-1998
  • [Journal-full-title] Pediatric radiology
  • [ISO-abbreviation] Pediatr Radiol
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] Germany
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6. Jang HJ, Kim TK, Wilson SR: Small nodules (1-2 cm) in liver cirrhosis: characterization with contrast-enhanced ultrasound. Eur J Radiol; 2009 Dec;72(3):418-24
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Small nodules (1-2 cm) in liver cirrhosis: characterization with contrast-enhanced ultrasound.
  • OBJECTIVE: To determine the diagnostic efficacy of arterial phase contrast-enhanced ultrasound (CEUS) for characterizing small hepatic nodules (1-2 cm) in patients with high-risk for hepatocellular carcinoma (HCC).
  • MATERIALS AND METHODS: Over 12 months, CEUS was performed in 59 patients at high-risk for HCC with small hepatic nodules (1-2 cm; mean, 1.5 cm).
  • Based only on arterial phase (<45 s) vascular intensity and pattern, lesions were prospectively diagnosed as HCC if there was hypervascularity without known features of hemangioma.
  • The diagnosis of HCC was made regardless of the presence or absence of washout.
  • Verification of diagnosis was made by liver transplantation (n=13), biopsy (n=12), resection (n=3) or clinical and imaging follow-up for at least 12 months (n=31).
  • RESULTS: At of the time of CEUS, the 59 nodules were diagnosed as HCC in 26 and benign lesions in 33, including 20 regenerative/dysplastic nodules (RN/DN), 11 hemangiomas, and 2 focal fat sparing.
  • All 26 nodules with arterial phase hypervascularity without hemangioma-like features were HCC.
  • CEUS correctly diagnosed all 11 hemangiomas.
  • CONCLUSIONS: Arterial phase vascular intensity and pattern of CEUS are highly accurate for the diagnosis of small (1-2 cm) HCC and hemangioma in liver cirrhosis.
  • On CEUS, arterial phase hypervascularity without a hemangioma-pattern alone may be sufficient for diagnosis of small HCC.
  • [MeSH-major] Carcinoma, Hepatocellular / ultrasonography. Fluorocarbons. Image Enhancement / methods. Liver Cirrhosis / ultrasonography. Liver Neoplasms / ultrasonography

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  • (PMID = 18834687.001).
  • [ISSN] 1872-7727
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Definity; 0 / Fluorocarbons
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7. Oto A, Kulkarni K, Nishikawa R, Baron RL: Contrast enhancement of hepatic hemangiomas on multiphase MDCT: Can we diagnose hepatic hemangiomas by comparing enhancement with blood pool? AJR Am J Roentgenol; 2010 Aug;195(2):381-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Contrast enhancement of hepatic hemangiomas on multiphase MDCT: Can we diagnose hepatic hemangiomas by comparing enhancement with blood pool?
  • OBJECTIVE: The purpose of this article is to determine whether enhancement of nodular foci within hemangiomas is homogeneous and matches blood vessels at different phases on contrast-enhanced MDCT.
  • MATERIALS AND METHODS: Multiphase (unenhanced, arterial, portal venous, and delayed phases) MDCT images of 58 hemangiomas were reviewed by two radiologists.
  • Nodular-enhancing foci within hemangiomas were evaluated for enhancement pattern and were subjectively compared with enhancement of the aorta, inferior vena cava, hepatic vein, and portal vein for each contrast-enhanced phase.
  • RESULTS: Qualitative analysis showed heterogeneously enhancing nodules in 79.3% and 65.5% of hemangiomas in the arterial phase and in 74.1% and 53.4% of hemangiomas in the portal venous phase, according to readers 1 and 2, respectively.
  • In the portal venous phase, 15.4% and 21.7%, 16.8% and 18.2%, 14.1% and 23.8%, and 19.5% and 25.9% of nodules were scored with enhancement similar to that in the aorta, inferior vena cava, hepatic vein, and portal vein by readers 1 and 2, respectively.
  • CONCLUSION: Attenuation of enhancing foci within hemangiomas does not match vessel density qualitatively or quantitatively.
  • Although persistent enhancement without washout is a useful CT criterion, specific criteria to match the blood pool cannot be used to confirm a diagnosis of hemangioma.
  • [MeSH-major] Hemangioma / radiography. Liver Neoplasms / radiography. Tomography, X-Ray Computed / methods

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  • (PMID = 20651193.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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8. Shimada K, Nakamoto Y, Isoda H, Saito H, Arizono S, Shibata T, Togashi K: FDG PET for giant cavernous hemangioma: important clue to differentiate from a malignant vascular tumor in the liver. Clin Nucl Med; 2010 Dec;35(12):924-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] FDG PET for giant cavernous hemangioma: important clue to differentiate from a malignant vascular tumor in the liver.
  • Giant cavernous hemangioma of the liver sometimes has a very inhomogeneous appearance with intratumoral degeneration on computed tomography or magnetic resonance imaging, and may mimic a malignant hepatic tumor, including angiosarcoma.
  • There are many reports about F-18 fluorodeoxyglucose (FDG) uptake of angiosarcoma; however, knowledge regarding positron emission tomography findings with FDG for giant hepatic cavernous hemangioma is still limited.
  • We herein present 2 cases of giant hepatic cavernous hemangioma in which low FDG uptake was considered helpful to differentiate from malignant hepatic tumor.
  • [MeSH-major] Fluorodeoxyglucose F18. Hemangioma, Cavernous / radionuclide imaging. Liver Neoplasms / radionuclide imaging. Positron-Emission Tomography
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Middle Aged

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  • (PMID = 21206221.001).
  • [ISSN] 1536-0229
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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9. Masui T, Katayama M, Nakagawara M, Shimizu S, Kojima K: Exophytic giant cavernous hemangioma of the liver with growing tendency. Radiat Med; 2005 Mar;23(2):121-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Exophytic giant cavernous hemangioma of the liver with growing tendency.
  • Hepatic hemangioma is a common benign tumor, but its exophytic and expansile forms may be atypical.
  • We report a case of exophytic hemangioma of the liver with a growing tendency, demonstrated using magnetic resonance imaging (MRI) and computed tomography (CT) combined with angiography.
  • [MeSH-major] Hemangioma, Cavernous / diagnosis. Liver Neoplasms / diagnosis

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  • (PMID = 15827530.001).
  • [ISSN] 0288-2043
  • [Journal-full-title] Radiation medicine
  • [ISO-abbreviation] Radiat Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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10. Sylvestre VT, Dunton CJ: Treatment of recurrent endometrial stromal sarcoma with letrozole: a case report and literature review. Horm Cancer; 2010 Apr;1(2):112-5
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  • She had a computed tomography that showed a pelvic mass, an enlarged right internal iliac lymph node, an atypical liver hemangioma, and a severe left hydronephrosis.

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  • (PMID = 21761354.001).
  • [ISSN] 1868-8500
  • [Journal-full-title] Hormones & cancer
  • [ISO-abbreviation] Horm Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Hormonal; 0 / Aromatase Inhibitors; 0 / Nitriles; 0 / Triazoles; 7LKK855W8I / letrozole
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11. Mzali R, Affess N, Gharbi A, Boujelbene S, Beyrouti MI: [Enucleation of an hepatic hemangioma: case report]. Tunis Med; 2008 Jan;86(1):89-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Enucleation of an hepatic hemangioma: case report].
  • [Transliterated title] Enucléation d'un angiome du foie: a propos d'un cas.
  • [MeSH-major] Hemangioma / surgery. Liver Neoplasms / surgery

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  • (PMID = 19472713.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] fre
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Tunisia
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12. Griffa B, Basilico V, Bellotti R, Griffa A, Senatore S, Capriata G: [Spontaneous rupture of giant subcapsular hemangioma of the liver with hemoperitoneum and hemorrhagic shock: a case report]. Chir Ital; 2005 May-Jun;57(3):389-92
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  • [Title] [Spontaneous rupture of giant subcapsular hemangioma of the liver with hemoperitoneum and hemorrhagic shock: a case report].
  • [Transliterated title] Rottura spontanea di emangioma gigante sottocapsulare del fegato con emoperitoneo e shock emorragico: presentazione di un caso clinico.
  • Cavernous hemangioma is the most common benign tumour of the liver and is found quite commonly during abdominal ultrasonography performed for other diseases.
  • Spontaneous rupture of a giant hepatic hemangioma (diameter > 4 cm) with hemoperitoneum occurs very rarely.
  • We describe a new case of a giant subcapsular hemangioma localised in hepatic segments II and III in an 84-year-old woman, which ruptured spontaneously into the abdominal cavity and presented with hemoperitoneum and hypovolaemic shock.
  • The hemangioma was diagnosed preoperatively by spiral CAT and treated successfully with emergency hepatic bisegmentectomy.
  • [MeSH-major] Hemangioma, Cavernous / complications. Hemoperitoneum / etiology. Liver Neoplasms / complications. Shock, Hemorrhagic / etiology

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  • (PMID = 16231832.001).
  • [ISSN] 0009-4773
  • [Journal-full-title] Chirurgia italiana
  • [ISO-abbreviation] Chir Ital
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
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13. Corsale I, Buccianelli E, Rigutini M, Mori P, Bartolomei M, Aloise F, Sorce S, Veltroni A: [Liver haemangioma: current surgical indications. Our experience]. G Chir; 2005 Apr;26(4):153-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Liver haemangioma: current surgical indications. Our experience].
  • Hemangiomas are the more frequent benign liver tumours.
  • Therapeutic approach at these neoplasms is changed in the last years because has resulted that massive haemoperitoneum from a spontaneous rupture of the hemangiomas is a rare occurrence.
  • From a personal review of 124 liver resection performed for traumatic and organic, benign and malignant, pathologies, the Authors present two cases of symptomatic liver haemangioma surgically treated Excluding emergency induced by tumour hemorrhage, actually indications to surgical treatment are controversial.
  • In all patients the right approach is choice by the integrated evaluation of general conditions of the patient, liver functionality and from anatomical location of the neoplasm.
  • [MeSH-major] Hemangioma / surgery. Hepatectomy / standards. Liver Neoplasms / surgery

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  • (PMID = 16035251.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
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14. Ontachi Y, Asakura H, Omote M, Yoshida T, Matsui O, Nakao S: Kasabach-Merritt syndrome associated with giant liver hemangioma: the effect of combined therapy with danaparoid sodium and tranexamic acid. Haematologica; 2005 Nov;90 Suppl:ECR29
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Kasabach-Merritt syndrome associated with giant liver hemangioma: the effect of combined therapy with danaparoid sodium and tranexamic acid.
  • A 39-year-old woman with an enlarging giant liver hemangioma was diagnosed as having KMS with DIC.
  • Rapid improvement of the bleeding tendency and coagulopathy occurred in response to this treatment - that is, DIC was controlled without removing the giant hemangioma.
  • [MeSH-major] Antifibrinolytic Agents / therapeutic use. Chondroitin Sulfates / therapeutic use. Dermatan Sulfate / therapeutic use. Disseminated Intravascular Coagulation / etiology. Hemangioma / complications. Hemorrhagic Disorders / etiology. Heparitin Sulfate / therapeutic use. Liver Neoplasms / complications. Tranexamic Acid / therapeutic use
  • [MeSH-minor] Adult. Blood Proteins / analysis. Drug Therapy, Combination. Female. Hepatic Artery / surgery. Humans. Ligation. Syndrome

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  • (PMID = 16266920.001).
  • [ISSN] 1592-8721
  • [Journal-full-title] Haematologica
  • [ISO-abbreviation] Haematologica
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antifibrinolytic Agents; 0 / Blood Proteins; 24967-94-0 / Dermatan Sulfate; 6T84R30KC1 / Tranexamic Acid; 83513-48-8 / danaproid; 9007-28-7 / Chondroitin Sulfates; 9050-30-0 / Heparitin Sulfate
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15. Magnies M, Giezek F, Jouandeau V, Custoza E: [Multiple calvarial cavernous hemangiomas]. J Neuroradiol; 2009 Dec;36(5):294-7
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  • [Title] [Multiple calvarial cavernous hemangiomas].
  • [Transliterated title] Multiples hémangiomes caverneux de la voûte du crâne.
  • Intraosseous cavernous hemangioma is rarely located in the calvarium.
  • This benign tumor, arising from the intrinsic vasculature of bone, grows slowly over a period of years before it causes symptoms such as headaches or localized compression.
  • We report here the case of a 27-year-old man, who presented with multiple calvarial cavernous hemangiomas associated with several hepatic hemangiomas.
  • The patient had a family history of the disease, and is only the second case of multiple calvarial cavernous hemangiomas reported in the literature.
  • [MeSH-major] Hemangioma, Cavernous / pathology. Neoplasms, Multiple Primary / pathology. Skull Neoplasms / pathology
  • [MeSH-minor] Adult. Contrast Media. Gadolinium. Humans. Liver Neoplasms / pathology. Magnetic Resonance Imaging. Male

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  • (PMID = 19403170.001).
  • [ISSN] 0150-9861
  • [Journal-full-title] Journal of neuroradiology. Journal de neuroradiologie
  • [ISO-abbreviation] J Neuroradiol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Contrast Media; AU0V1LM3JT / Gadolinium
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16. Nord KM, Kandel J, Lefkowitch JH, Lobritto SJ, Morel KD, North PE, Garzon MC: Multiple cutaneous infantile hemangiomas associated with hepatic angiosarcoma: case report and review of the literature. Pediatrics; 2006 Sep;118(3):e907-13
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  • [Title] Multiple cutaneous infantile hemangiomas associated with hepatic angiosarcoma: case report and review of the literature.
  • Multiple cutaneous hemangiomas can be associated with internal hemangiomas, with the liver being the most common site.
  • Here we report a case of a premature female neonate who presented with cardiac failure at birth and had typical-appearing infantile hemangiomas on the skin in association with vascular lesions in the liver.
  • Her clinical presentation was felt to be consistent with cutaneous and hepatic infantile hemangiomas.
  • After failure to respond to systemic steroids and chemotherapy, she underwent liver transplantation.
  • Histopathologic evaluation of the liver revealed a diagnosis of type 2 infantile hepatic hemangioendothelioma (regarded as synonymous with angiosarcoma) rather than benign infantile hemangioma of the liver.
  • Subsequent skin biopsies confirmed that her multiple cutaneous lesions were infantile hemangiomas and not metastatic angiosarcoma.
  • We report this case and a review of the literature on pediatric angiosarcoma of the liver associated with cutaneous infantile hemangiomas.
  • [MeSH-major] Hemangioma / pathology. Hemangiosarcoma / pathology. Liver Neoplasms / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Female. Heart Defects, Congenital. Humans. Infant, Newborn. Liver Transplantation

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  • [ErratumIn] Pediatrics. 2007 Jun;119(6):1271
  • (PMID = 16880251.001).
  • [ISSN] 1098-4275
  • [Journal-full-title] Pediatrics
  • [ISO-abbreviation] Pediatrics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 27
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17. Au WY, Liu CL: Growth of giant hepatic hemangioma after triplet pregnancy. J Hepatol; 2005 May;42(5):781
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Growth of giant hepatic hemangioma after triplet pregnancy.
  • [MeSH-major] Hemangioma / etiology. Hemangioma / pathology. Liver / blood supply. Pregnancy Complications, Cardiovascular / pathology. Triplets

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  • (PMID = 15826730.001).
  • [ISSN] 0168-8278
  • [Journal-full-title] Journal of hepatology
  • [ISO-abbreviation] J. Hepatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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18. Chang X, Han J, Pang L, Zhao Y, Yang Y, Shen Z: Increased PADI4 expression in blood and tissues of patients with malignant tumors. BMC Cancer; 2009;9:40
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  • However, PADI4 expression was not observed in benign leiomyomas of stomach, uterine myomas, endometrial hyperplasias, cervical polyps, teratomas, hydatidiform moles, trophoblastic cell hyperplasias, hyroid adenomas, hemangiomas, lymph hyperplasias, schwannomas, neurofibromas, lipomas, and cavernous hemangiomas of the liver.
  • ELISA detected increased PADI4 and cAT levels in the blood of patients with various malignant tumors compared to those in patients with chronic inflammation and benign tumors.

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  • (PMID = 19183436.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antithrombins; 0 / Neoplasm Proteins; 29VT07BGDA / Citrulline; EC 3.- / Hydrolases; EC 3.5.3.15 / peptidylarginine deiminase type IV
  • [Other-IDs] NLM/ PMC2637889
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19. Kim EH, Park SY, Ihn YK, Hwang SS: Diffuse hepatic hemangiomatosis without extrahepatic involvement in an adult patient. Korean J Radiol; 2008 Nov-Dec;9(6):559-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diffuse hepatic hemangiomatosis without extrahepatic involvement in an adult patient.
  • We report an extremely rare case of a diffuse hepatic hemangiomatosis without extrahepatic involvement in an adult.
  • The imaging findings of this tumor were similar to those of a hepatic hemangioma and included contrast enhancement with a centripetal filling pattern of the entire hepatic tumor on the delayed phase of a dynamic CT and inhomogeneous diffuse uptake of the entire tumor on blood-pool images obtained five hours later on a 99mTc-labeled red blood cell scan.
  • Despite its rarity, diffuse hepatic hemangiomatosis can be suggested in adult patients with diffusely involved hepatic tumors showing the radiological findings of a hepatic hemangioma.
  • [MeSH-major] Hemangioma / diagnosis. Liver Neoplasms / diagnosis

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  • (PMID = 19039274.001).
  • [ISSN] 1229-6929
  • [Journal-full-title] Korean journal of radiology
  • [ISO-abbreviation] Korean J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2627242
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20. Kim GE, Thung SN, Tsui WM, Ferrell LD: Hepatic cavernous hemangioma: underrecognized associated histologic features. Liver Int; 2006 Apr;26(3):334-8
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  • [Title] Hepatic cavernous hemangioma: underrecognized associated histologic features.
  • BACKGROUND/AIMS: Cavernous hemangiomas (CH) are typically described as solitary, well-circumscribed lesions and are reported to have a distinct fibrous interface.
  • This study describes underrecognized histological changes of large hepatic hemangiomas that contradict this long-standing view.
  • METHODS: Nineteen cases of hepatic resections for CH were reviewed.
  • Stains for estrogen and progesterone receptors (ER/PR), MIB-1, alpha-smooth muscle actin, collagen IV, and elastic Van Gieson stains were applied to the lesions.
  • Sixteen (84%) CHs had an irregular interface with the liver parenchyma while only three had the well-defined fibrous capsule typically described for CH.
  • Fifteen (79%) CHs had dilated vascular spaces filled with blood 0.1-2.0 cm beyond the confines of the main CH, which we have designated hemangioma-like vessels (HLVs).
  • CONCLUSION: Irregular edges of CH and HLVs in the liver parenchyma adjacent to CH have been underrecognized.
  • [MeSH-major] Hemangioma, Cavernous / pathology. Liver Neoplasms / pathology

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  • (PMID = 16584396.001).
  • [ISSN] 1478-3223
  • [Journal-full-title] Liver international : official journal of the International Association for the Study of the Liver
  • [ISO-abbreviation] Liver Int.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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21. Banton KL, D'Cunha J, Laudi N, Flynn C, Hammerschmidt D, Humar A, Sielaff T: Postoperative severe microangiopathic hemolytic anemia associated with a giant hepatic cavernous hemangioma. J Gastrointest Surg; 2005 May-Jun;9(5):679-85
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  • [Title] Postoperative severe microangiopathic hemolytic anemia associated with a giant hepatic cavernous hemangioma.
  • Complications related to liver hemangioma are rare.
  • We herein describe the case of a patient with three giant cavernous hemangiomas of the liver, of which two were resected for symptoms.
  • Surgeons should be aware of the potential for hemolytic complications after major surgery when giant hepatic hemangiomas are present.
  • [MeSH-major] Anemia, Hemolytic / etiology. Hemangioma, Cavernous / pathology. Hemangioma, Cavernous / surgery. Liver Neoplasms / pathology. Liver Neoplasms / surgery. Postoperative Complications / diagnosis

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  • (PMID = 15862263.001).
  • [ISSN] 1091-255X
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 25
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22. Seitz K, Bernatik T, Strobel D, Blank W, Friedrich-Rust M, Strunk H, Greis C, Kratzer W, Schuler A: Contrast-enhanced ultrasound (CEUS) for the characterization of focal liver lesions in clinical practice (DEGUM Multicenter Trial): CEUS vs. MRI--a prospective comparison in 269 patients. Ultraschall Med; 2010 Oct;31(5):492-9
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  • [Title] Contrast-enhanced ultrasound (CEUS) for the characterization of focal liver lesions in clinical practice (DEGUM Multicenter Trial): CEUS vs. MRI--a prospective comparison in 269 patients.
  • PURPOSE: The aim of this prospective multicenter study was to assess the diagnostic role of CEUS in the diagnosis of newly discovered focal liver lesions in clinical practice.
  • MATERIALS AND METHODS: From 05 / 2004 to 12 / 2006, standardized CEUS was performed prospectively on 1349 patients with focal liver lesions that had been newly detected by fundamental ultrasound in order to determine tumor differentiation and tumor entity.
  • In typical liver hemangioma and focal nodular hyperplasia (FNH), the definitive diagnosis was based on the MRI as the "diagnostic gold standard" and on clinical evidence and additional follow-up (subgroup A) or on histology (subgroup B).
  • RESULTS: In the subcollective (n = 262), the tumor differentiation (malignant or benign) of CEUS and MRI was concordant in 225 cases (85.9%), and the assessment of tumor entity in 204 cases (77.9%).
  • Liver hemangiomas (n = 122) and FNH (n = 43) were most frequent.
  • Subgroup B (n = 82) comprised mainly malignant liver lesions (n = 55), with only a few of hemangiomas (n = 8) or FNH (n = 5).
  • CONCLUSION: CEUS and MRI are of equal value for the differentiation and specification of newly discovered liver tumors in clinical practice.
  • CEUS and MRI are extremely reliable for the differentiation of benign and malignant lesions, the diagnosis of liver hemangiomas and FNH.
  • [MeSH-major] Carcinoma, Hepatocellular / diagnosis. Focal Nodular Hyperplasia / diagnosis. Hemangioma / diagnosis. Image Enhancement. Image Processing, Computer-Assisted. Liver Neoplasms / diagnosis. Liver Neoplasms / secondary. Magnetic Resonance Imaging. Ultrasonography
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Cohort Studies. Contrast Media / administration & dosage. Dextrans. Diagnosis, Differential. Female. Gadolinium. Gadolinium DTPA. Heterocyclic Compounds. Humans. Liver / pathology. Liver Cirrhosis / diagnosis. Liver Cirrhosis / pathology. Magnetite Nanoparticles. Male. Middle Aged. Organometallic Compounds. Phospholipids. Prospective Studies. Sensitivity and Specificity. Software. Sulfur Hexafluoride. Young Adult

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  • [Copyright] © Georg Thieme Verlag KG Stuttgart · New York.
  • (PMID = 20652854.001).
  • [ISSN] 1438-8782
  • [Journal-full-title] Ultraschall in der Medizin (Stuttgart, Germany : 1980)
  • [ISO-abbreviation] Ultraschall Med
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Heterocyclic Compounds; 0 / Magnetite Nanoparticles; 0 / Organometallic Compounds; 0 / Phospholipids; 0 / contrast agent BR1; 0199MV609F / gadoteridol; AU0V1LM3JT / Gadolinium; G6N3J05W84 / ferumoxides; K2I13DR72L / Gadolinium DTPA; K3R6ZDH4DU / Dextrans; WS7LR3I1D6 / Sulfur Hexafluoride
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23. Di Carlo I, Sofia M, Toro A: Does the psychological request of the patient justify the surgery for hepatic hemangioma? Hepatogastroenterology; 2005 May-Jun;52(63):657-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Does the psychological request of the patient justify the surgery for hepatic hemangioma?
  • BACKGROUND/AIMS: The incidental finding of hemangiomas has increased, but the problem of the correct surgical indications of this tumor has yet to be solved.
  • The aim of this work is to establish whether the psychological request of surgery from patients known to have a benign tumor of the liver must be avoided or not.
  • METHODOLOGY: Age, sex, symptoms, estroprogestinic oral therapy, methods of diagnosis, surgical procedures, morbidity, mortality, postoperative hospital stay and follow-up of the patients affected by hepatic hemangioma, observed from 1992 to 2002 in our institution, have been considered.
  • RESULTS: Seventeen patients, with a mean age of 44 years (range 26-72), were hospitalized for hepatic hemangioma, 8 (47%) of them were operated on and 9 (53%) were managed by observation.
  • One patient was operated on for traumatic rupture of the hemangioma.
  • The types of surgical procedures were 5 enucleations, and 3 hepatic resections.
  • CONCLUSIONS: Our results suggest that liver hemangiomas should be operated for symptoms well related to the tumor or for bleeding.
  • [MeSH-major] Hemangioma, Cavernous / psychology. Sick Role

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  • (PMID = 15966176.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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24. Arkadopoulos N, Stafyla V, Karapanos K, Yiallourou AI, Koureas A, Kondi-Pafiti A, Smyrniotis V: Recurrent pulmonary embolism due to giant hepatic hamangioma treated with hepatectomy under vascular exclusion. Ann Vasc Surg; 2010 Aug;24(6):827.e1-3
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  • [Title] Recurrent pulmonary embolism due to giant hepatic hamangioma treated with hepatectomy under vascular exclusion.
  • Giant hepatic hemangiomas are benign tumors that measure more than 4 cm and are usually asymptomatic.
  • Pulmonary embolism (PE) is an extremely rare manifestation of giant hepatic hemangiomas.
  • We report a case of a 44-year-old woman who suffered of recurrent pulmonary emboli that, after thorough work up, were attributed to thrombi formation inside a giant hepatic hemangioma.
  • A right hepatectomy under vascular exclusion was performed and the hemangioma, measuring 17 cm, was resected.
  • The report highlights the value of investigating giant liver hemangiomas in case of PE.
  • In such cases, the hemangioma should be resected preferably under occlusion of the venous outflow of the liver to avoid PE intraoperatively.
  • [MeSH-major] Hemangioma / surgery. Hepatectomy. Hepatic Veins / surgery. Liver Neoplasms / surgery. Portal System / surgery. Pulmonary Embolism / prevention & control

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  • [Copyright] Copyright 2010 Annals of Vascular Surgery Inc. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20471202.001).
  • [ISSN] 1615-5947
  • [Journal-full-title] Annals of vascular surgery
  • [ISO-abbreviation] Ann Vasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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26. Du X, Bao G, He X, Zhao H, Yu F, Qiao Q, Lu J, Ma Q: Expression and biological significance of c-FLIP in human hepatocellular carcinomas. J Exp Clin Cancer Res; 2009;28:24
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  • RESULTS: Positive immunostaining was detected for c-FLIP in 83.72% (72/86) human HCC tissues, 14.81% (4/27) hepatic cirrhosis, 11.11% (2/18) hepatic hemangioma tissues, and absent in normal hepatic tissues.
  • [MeSH-major] CASP8 and FADD-Like Apoptosis Regulating Protein / biosynthesis. Carcinoma, Hepatocellular / metabolism. Liver Neoplasms / metabolism

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  • (PMID = 19232089.001).
  • [ISSN] 1756-9966
  • [Journal-full-title] Journal of experimental & clinical cancer research : CR
  • [ISO-abbreviation] J. Exp. Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / CASP8 and FADD-Like Apoptosis Regulating Protein; 0 / CFLAR protein, human; 0 / RNA, Messenger; 0 / RNA, Small Interfering; 80168379AG / Doxorubicin
  • [Other-IDs] NLM/ PMC2654864
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27. Fernández-Pineda I, Bernabeu-Wittel J: [Hepatic hemangiomas]. Gastroenterol Hepatol; 2010 Jun-Jul;33(6):473-4; author reply 474-5
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  • [Title] [Hepatic hemangiomas].
  • [Transliterated title] Hemangiomas hepáticos.
  • [MeSH-major] Hemangioma / classification. Hepatic Veins / abnormalities. Liver Neoplasms / classification. Terminology as Topic. Vascular Malformations / classification
  • [MeSH-minor] Adolescent. Adult. Age of Onset. Child. Embolization, Therapeutic. Female. Hemangioma, Capillary / classification. Hemangioma, Capillary / therapy. Humans. Infant. Infant, Newborn. Portacaval Shunt, Surgical. Pregnancy. Pregnancy Complications, Neoplastic. Vasoconstrictor Agents / therapeutic use

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  • [CommentOn] Gastroenterol Hepatol. 2010 May;33(5):391-7 [20096966.001]
  • (PMID = 20537429.001).
  • [ISSN] 0210-5705
  • [Journal-full-title] Gastroenterología y hepatología
  • [ISO-abbreviation] Gastroenterol Hepatol
  • [Language] spa
  • [Publication-type] Comment; Letter
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Vasoconstrictor Agents
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28. Wang QS, Liu L, Dong L, Shen ZL, Zhou DH, Hu CX: Laparoscopic Heller-Dor operation for patients with achalasia. Chin Med J (Engl); 2006 Mar 20;119(6):443-7; discussion 447-8
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  • All the patients received upper gastrointestinal series (barium swallow), esophagogastroscopy, esophageal manometry to exclude esophageal carcinoma and to confirm the diagnosis, and 21 patients also had 24-hour ambulatory pH studies.
  • In addition, 2 of them had combined laparoscopic cholecystectomy + excision of hepatic hemangioma and laparoscopic cholecystectomy, respectively.

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  • (PMID = 16584640.001).
  • [ISSN] 0366-6999
  • [Journal-full-title] Chinese medical journal
  • [ISO-abbreviation] Chin. Med. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
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29. Zakavi R: How should we image liver hemangioma? Hell J Nucl Med; 2006 Sep-Dec;9(3):187
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  • [Title] How should we image liver hemangioma?
  • [MeSH-major] Erythrocytes / radionuclide imaging. Hemangioma / radionuclide imaging. Liver Neoplasms / radionuclide imaging. Technetium. Technetium Tc 99m Sulfur Colloid. Tomography, Emission-Computed, Single-Photon / methods

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  • [CommentOn] Hell J Nucl Med. 2006 May-Aug;9(2):109-10 [16894416.001]
  • (PMID = 17160164.001).
  • [ISSN] 1790-5427
  • [Journal-full-title] Hellenic journal of nuclear medicine
  • [ISO-abbreviation] Hell J Nucl Med
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 556Q0P6PB1 / Technetium Tc 99m Sulfur Colloid; 7440-26-8 / Technetium
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30. Brody JM, Schafer L, Tung GA, Breuer J, Shamsi K: Conspicuity of liver hemangiomas: short tau inversion recovery, T1, and T2 imaging with gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid. J Magn Reson Imaging; 2005 Apr;21(4):391-7
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  • [Title] Conspicuity of liver hemangiomas: short tau inversion recovery, T1, and T2 imaging with gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid.
  • PURPOSE: To compare conspicuity of liver hemangiomas on STIR, T1-weighted, and T2-weighted magnetic resonance (MR) images before and after administration of gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd-EOB-DTPA) (hepatocellular contrast agent), using contrast-to-noise ratios (CNRs).
  • MATERIALS AND METHODS: Thirteen hemangiomas were imaged using breath-hold gradient echo (GRE) T1, fat-saturated turbo spin echo (TSE)-T2, and short tau inversion recovery (STIR) sequences.
  • Background noise and signal-to-noise ratios (SNRs) for liver and hemangioma, along with CNR for normal liver and hemangioma, were measured on each sequence before and after administration of Gd-EOB-DTPA.
  • Hemangioma conspicuity was also evaluated qualitatively.
  • RESULTS: After Gd-EOB-DTPA administration, the quantitative liver SNR decreased 54% on STIR, increased 45% on T1-weighted images, and increased 14.5% on TSE-T2-weighted images.
  • The CNR for liver and hemangioma increased 50% on STIR images (P < 0.0001), increased 46% on T1-weighted imaging (P = 0.0033), and increased 22% on TSE-T2-weighted MR imaging (MRI) (P = 0.0083).
  • Qualitatively, signal change was visually apparent in the liver on T1 and STIR, but not on T2 images or in the hemangiomas on any sequence.
  • CONCLUSION: Despite the statistically significant T1 and STIR increase in CNR, liver hemangiomas were most conspicuous on TSE-T2 images after Gd-EOB-DTPA.
  • This pilot study with hemangiomas highlights the newly recognized potential benefit of TSE-T2 imaging with hepatocellular contrast.
  • [MeSH-major] Contrast Media. Gadolinium DTPA. Hemangioma / diagnosis. Liver Neoplasms / diagnosis. Magnetic Resonance Imaging / methods

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  • [Copyright] Copyright 2005 Wiley-Liss, Inc.
  • (PMID = 15778951.001).
  • [ISSN] 1053-1807
  • [Journal-full-title] Journal of magnetic resonance imaging : JMRI
  • [ISO-abbreviation] J Magn Reson Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 0 / gadolinium ethoxybenzyl DTPA; K2I13DR72L / Gadolinium DTPA
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36. Assy N, Nasser G, Djibre A, Beniashvili Z, Elias S, Zidan J: Characteristics of common solid liver lesions and recommendations for diagnostic workup. World J Gastroenterol; 2009 Jul 14;15(26):3217-27
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  • [Title] Characteristics of common solid liver lesions and recommendations for diagnostic workup.
  • Due to the widespread clinical use of imaging modalities such as ultrasonography, computed tomography and magnetic resonance imaging (MRI), previously unsuspected liver masses are increasingly being found in asymptomatic patients.
  • This review discusses the various characteristics of the most common solid liver lesions and recommends a practical approach for diagnostic workup.
  • Likely diagnoses include hepatocellular carcinoma (the most likely; a solid liver lesion in a cirrhotic liver) and hemangioma (generally presenting as a mass in a non-cirrhotic liver).
  • Focal nodular hyperplasia and hepatic adenoma should be ruled out in young women.
  • If the patient is known to have a primary malignancy and the lesion was found at tumor staging or follow up, histology is required only when the nature of the liver lesion is doubtful.
  • [MeSH-major] Diagnostic Imaging / methods. Liver Neoplasms
  • [MeSH-minor] Algorithms. Biomarkers, Tumor / metabolism. Biopsy. Biopsy, Fine-Needle. Humans. Incidental Findings. Liver Cirrhosis / pathology

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  • (PMID = 19598296.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 131
  • [Other-IDs] NLM/ PMC2710776
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37. Wang CN, He XL, Zhang HB, Ding HX: [Littoral cell angioma of the spleen in a patient with chronic hepatitis B and hepatocellular carcinoma]. Zhonghua Bing Li Xue Za Zhi; 2007 Dec;36(12):858-9
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  • [Title] [Littoral cell angioma of the spleen in a patient with chronic hepatitis B and hepatocellular carcinoma].
  • [MeSH-major] Carcinoma, Hepatocellular / complications. Hemangioma / complications. Hemangioma / diagnosis. Hepatitis B, Chronic / complications. Spleen / pathology
  • [MeSH-minor] Antigens, CD31 / immunology. Hepatocytes / cytology. Hepatocytes / pathology. Humans. Liver Cirrhosis / complications. Liver Neoplasms / complications. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 18346365.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD31
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38. Scialpi M, Piscioli I, Brunese L, Lupattelli L: Cavernous malformation or cavernous hemangioma: an appropriate term to define liver hemangioma. Eur Radiol; 2008 Dec;18(12):2854; author reply 2854
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  • [Title] Cavernous malformation or cavernous hemangioma: an appropriate term to define liver hemangioma.
  • [MeSH-major] Hemangioma / diagnosis. Liver / abnormalities. Liver / diagnostic imaging. Liver Neoplasms / diagnosis
  • [MeSH-minor] Contrast Media. Diagnosis, Differential. Diagnostic Imaging. Humans. Radiography

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  • [CommentOn] Eur Radiol. 2007 Jun;17(6):1544-54 [17260159.001]
  • [Cites] Surg Today. 2005;35(9):796-9 [16133680.001]
  • [Cites] Eur Radiol. 2007 Jun;17(6):1544-54 [17260159.001]
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  • (PMID = 18618123.001).
  • [ISSN] 1432-1084
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Letter; Comment
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media
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39. Aksenov IV, Fedorchenko AN: [Hepatic hemangioma: the choice of treatment]. Khirurgiia (Mosk); 2010;(6):40-2
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  • [Title] [Hepatic hemangioma: the choice of treatment].
  • 117 patients with hepatic hemangioma were treated.
  • The possibility and technical features of liver resections by hepatic hemangiomas are discussed.
  • Authors state the necessity of reduction of surgical treatment of hepatic hemangiomas and substantiate the need of dynamic observation of such lesions of the liver.
  • [MeSH-major] Hemangioma / surgery. Liver Neoplasms / surgery

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  • (PMID = 20559223.001).
  • [ISSN] 0023-1207
  • [Journal-full-title] Khirurgiia
  • [ISO-abbreviation] Khirurgiia (Mosk)
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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40. Artiko MV, Sobić-Saranović PD, Perisić-Savić SM, Stojković VM, Radoman BI, Knezević SJ, Petrović SN, Obradović BV, Milović V: 99mTc-red blood cells SPECT and planar scintigraphy in the diagnosis of hepatic hemangiomas. Acta Chir Iugosl; 2008;55(4):23-6
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  • [Title] 99mTc-red blood cells SPECT and planar scintigraphy in the diagnosis of hepatic hemangiomas.
  • The aim of the study is the assessment of the value of SPECT (single photon emission computerized tomography) using 99mTc-labeled red blood cells in the detection of liver hemangioma, in comparison to planar imaging.
  • [MeSH-major] Hemangioma / radionuclide imaging. Liver Neoplasms / radionuclide imaging. Sodium Pertechnetate Tc 99m. Tomography, Emission-Computed, Single-Photon
  • [MeSH-minor] Adult. Erythrocytes. Female. Humans. Liver / radionuclide imaging. Male. Middle Aged. Predictive Value of Tests. Sensitivity and Specificity. Young Adult

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  • (PMID = 19245136.001).
  • [ISSN] 0354-950X
  • [Journal-full-title] Acta chirurgica Iugoslavica
  • [ISO-abbreviation] Acta Chir Iugosl
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Serbia
  • [Chemical-registry-number] A0730CX801 / Sodium Pertechnetate Tc 99m
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41. Akamatsu N, Sugawara Y, Komagome M, Ishida T, Shin N, Cho N, Ozawa F, Hashimoto D: Giant liver hemangioma resected by trisectorectomy after efficient volume reduction by transcatheter arterial embolization: a case report. J Med Case Rep; 2010;4:283
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  • [Title] Giant liver hemangioma resected by trisectorectomy after efficient volume reduction by transcatheter arterial embolization: a case report.
  • INTRODUCTION: Liver hemangiomas are the most common benign liver tumors, usually small in size and requiring no treatment.
  • Giant hemangiomas complicated with consumptive coagulopathy (Kasabach-Merritt syndrome) or causing severe incapacitating symptoms, however, are generally considered an absolute indication for surgical resection.
  • Here, we present the case of a giant hemangioma, which was, to the best of our knowledge, one of the largest ever reported.
  • Examinations at the first visit revealed a right liver hemangioma occupying the abdominal cavity, protruding into the right diaphragm up to the right thoracic cavity and extending down to the pelvic cavity, with a maximum diameter of 43 cm, complicated with "asymptomatic" Kasabach-Merritt syndrome.
  • Based on the tumor size and the anatomic relationship between the tumor and hepatic vena cava, primary resection seemed difficult and dangerous, leading us to first perform transcatheter arterial embolization to reduce the tumor volume and to ensure the safety of future resection.
  • CONCLUSIONS: To date, there have been several reports of aggressive surgical treatments, including extra-corporeal hepatic resection and liver transplantation, for huge hemangiomas like the present case, but because of its benign nature, every effort should be made to avoid life-threatening surgical stress for patients.
  • Our experience demonstrates that a pre-operative arterial embolization may effectively enable the resection of large hemangiomas.

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  • (PMID = 20731839.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2936318
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42. Berloco P, Bruzzone P, Mennini G, Della Pietra F, Iappelli M, Novelli G, Rossi M: Giant hemangiomas of the liver: surgical strategies and technical aspects. HPB (Oxford); 2006;8(3):200-1
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  • [Title] Giant hemangiomas of the liver: surgical strategies and technical aspects.
  • The incidence of hemangiomas is 2-7% in the general population.
  • We evaluated more than 300 patients with hepatic hemangiomas.
  • Surgical removal of hepatic hemangiomas was performed in 48 cases due to uncertain diagnosis (2 cases), intractable symptoms (26 cases), size increase (18 cases), and liver failure in 2 cases that were treated by hepatic transplantation.
  • In all, 26 patients underwent enucleation of hemangiomas or segmentectomies, while the remaining 20 patients underwent right lobectomies or left lateral segmentectomies.
  • Blood transfusions were required in four cases (including two liver transplants); mean post-resection hospital stay was 6.3 days.
  • Our experience confirms that, after adequate patient selection, surgical treatment of hepatic hemangiomas is a very effective therapeutic choice with no mortality and low morbidity.

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  • [Cites] Br J Surg. 1996 Jul;83(7):915-8 [8813773.001]
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  • (PMID = 18333276.001).
  • [ISSN] 1365-182X
  • [Journal-full-title] HPB : the official journal of the International Hepato Pancreato Biliary Association
  • [ISO-abbreviation] HPB (Oxford)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2131674
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43. Rademaker J, Kim YJ, Leibecke T, Raman SS, Voit C: Cowden disease: CT findings in three patients. Abdom Imaging; 2005 Mar-Apr;30(2):204-7
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  • Cowden disease, also known as multiple hamartoma syndromes, is an autosomal dominant disease characterized by numerous benign mucocutaneous tumors, hamartomas of multiple organs, and malignancies of the breast and thyroid.
  • In addition to the classic findings, the patients were diagnosed with spinal neurinoma (n=1), meningioma (n=1), and hepatic hemangioma (n=3).
  • [MeSH-minor] Adult. Diagnosis, Differential. Duodenum / radiography. Female. Follow-Up Studies. Humans. Liver / radiography. Lung / radiography. Retrospective Studies. Tomography, X-Ray Computed

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  • (PMID = 15812679.001).
  • [ISSN] 0942-8925
  • [Journal-full-title] Abdominal imaging
  • [ISO-abbreviation] Abdom Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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44. Kim KW, Kim AY, Kim TK, Kim SY, Kim MJ, Park MS, Park SH, Lee KH, Kim JK, Kim PN, Ha HK, Lee MG: Hepatic hemangiomas with arterioportal shunt: sonographic appearances with CT and MRI correlation. AJR Am J Roentgenol; 2006 Oct;187(4):W406-14
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  • [Title] Hepatic hemangiomas with arterioportal shunt: sonographic appearances with CT and MRI correlation.
  • OBJECTIVE: The purpose of this study was to summarize and illustrate the sonographic appearance of hepatic hemangiomas with arterioportal shunt and to correlate them with CT and MRI findings.
  • CONCLUSION: High-flow hepatic hemangiomas tend to be seen as hypoechoic lesions at sonography.
  • In the presence of fatty infiltration in the liver, they may accompany peritumoral low-echoic areas presumably caused by peritumoral sparing of fatty infiltration similar to a hyperattenuating or hyperintense peritumoral rim on unenhanced CT or MR chemical shift imaging.
  • Knowledge of such sonographic findings may ensure an accurate sonographic diagnosis of these tumors.
  • [MeSH-major] Hemangioma / ultrasonography. Liver Neoplasms / ultrasonography. Magnetic Resonance Imaging. Tomography, X-Ray Computed
  • [MeSH-minor] Adult. Fatty Liver / complications. Fatty Liver / radiography. Fatty Liver / ultrasonography. Female. Hepatic Artery / radiography. Hepatic Artery / ultrasonography. Humans. Male. Middle Aged. Portal Vein / radiography. Portal Vein / ultrasonography

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  • (PMID = 16985113.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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45. Blondet A, Ridereau-Zins C, Michalak S, Pessaux P, Aubertin A, Aubé C: [Multiple pedunculated liver hemangiomas presenting with volvulus]. J Radiol; 2007 Jun;88(6):891-4
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  • [Title] [Multiple pedunculated liver hemangiomas presenting with volvulus].
  • [MeSH-major] Hemangioma / complications. Intestinal Volvulus / etiology. Liver Neoplasms / complications

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  • (PMID = 17652983.001).
  • [ISSN] 0221-0363
  • [Journal-full-title] Journal de radiologie
  • [ISO-abbreviation] J Radiol
  • [Language] fre
  • [Publication-type] Case Reports; Letter
  • [Publication-country] France
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46. Bernini GP, Moretti A, Mannelli M, Ercolino T, Bardini M, Caramella D, Taurino C, Salvetti A: Unique association of non-functioning pheochromocytoma, ganglioneuroma, adrenal cortical adenoma, hepatic and vertebral hemangiomas in a patient with a new intronic variant in the VHL gene. J Endocrinol Invest; 2005 Dec;28(11):1032-7
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  • [Title] Unique association of non-functioning pheochromocytoma, ganglioneuroma, adrenal cortical adenoma, hepatic and vertebral hemangiomas in a patient with a new intronic variant in the VHL gene.
  • In addition, CT and MR revealed a vertebral and two hepatic hemangiomas.
  • [MeSH-major] Adrenal Gland Neoplasms / genetics. Adrenocortical Adenoma / genetics. Ganglioneuroma / genetics. Hemangioma / genetics. Liver Neoplasms / genetics. Neoplasms, Multiple Primary. Pheochromocytoma / genetics. Spinal Neoplasms / genetics. Von Hippel-Lindau Tumor Suppressor Protein / genetics

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  • (PMID = 16483185.001).
  • [ISSN] 0391-4097
  • [Journal-full-title] Journal of endocrinological investigation
  • [ISO-abbreviation] J. Endocrinol. Invest.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / DNA, Neoplasm; EC 2.3.2.27 / Von Hippel-Lindau Tumor Suppressor Protein; EC 6.3.2.- / VHL protein, human
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47. Aseni P, Lauterio A, Slim AO, Giacomoni A, Lamperti L, De Carlis L: Life-saving super-urgent liver transplantation with replacement of retrohepatic vena cava by dacron graft. HPB Surg; 2010;2010
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  • [Title] Life-saving super-urgent liver transplantation with replacement of retrohepatic vena cava by dacron graft.
  • We describe a modified technique of side-to-side cavo-cavostomy by Dacron interposition prosthesis during a super urgent liver transplantation.
  • A liver graft from a deceased donor was immediately requested on a top priority basis as a consequence of massive bleeding during extended left hepatectomy for a huge hepatic haemangioma arising from the caudate lobe.
  • A liver graft from a deceased donor was available 16 hours later.
  • Due to the shortness of the vena cava of the donor liver graft, the removal of the Dacron graft was impossible and a modified side-to-side cavo-cavostomy between the Dacron interposition graft and the vena cava of the donor liver was than performed.
  • Liver transplantation was uneventful and the patient is doing well 25 months after the surgical procedure.
  • Although the use of synthetic vascular prosthesis should usually be discouraged during organ transplantation, its exceptional use during liver transplantation is possible with long-term good results.

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  • (PMID = 20811479.001).
  • [ISSN] 1607-8462
  • [Journal-full-title] HPB surgery : a world journal of hepatic, pancreatic and biliary surgery
  • [ISO-abbreviation] HPB Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2926580
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48. Ng WW, Cheung YS, Lee KF, Wong J, Yu SC, Lee PS, Lai PB: Is regular follow-up scan for giant liver haemangioma necessary? Hong Kong Med J; 2007 Oct;13(5):353-8
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  • [Title] Is regular follow-up scan for giant liver haemangioma necessary?
  • OBJECTIVES: To review the reliability of radiological diagnosis and need of regular scans for giant liver haemangioma, in terms of long-term outcome and management options.
  • PATIENTS: Patients with giant liver haemangioma noted on initial imaging from February 1996 to July 2006.
  • RESULTS: There were 42 female and 22 male patients with a median age of 49 (range, 27-84) years with a suspected haemangioma.
  • Besides regular follow-up scans, 22 patients were investigated further to confirm the diagnosis/exclude malignancy.
  • Finally, 63 patients had a haemangioma and one had a hepatocellular carcinoma.
  • Most (54%) of the patients were asymptomatic, but in 17% the haemangioma enlarged to exceed its original size by more than 20%.
  • There were no haemangioma-associated complications.
  • CONCLUSIONS: Majority of patients having giant liver haemangioma are asymptomatic and do not suffer complications.
  • If the diagnosis is uncertain, selective further investigations may be necessary.
  • Lesions with a confirmed diagnosis tend to remain static in size; performing regular scans for asymptomatic giant liver haemangiomas may not be necessary.

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  • (PMID = 17914140.001).
  • [ISSN] 1024-2708
  • [Journal-full-title] Hong Kong medical journal = Xianggang yi xue za zhi
  • [ISO-abbreviation] Hong Kong Med J
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] China
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49. Kajihara Y, Ikawa F, Ohbayashi N, Imada Y, Hidaka T, Matsushige T, Mitsuhara T, Inagawa T, Ohama E: [Hemangioendothelioma of the brain presenting with intracerebral hemorrhage: a case report]. No To Shinkei; 2005 Aug;57(8):690-4
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  • Hemangioendothelioma (HE) is an uncommon vascular tumor that is intermediate in histological appearance between a hemangioma and an angiosarcoma.
  • It has been reported in the liver, lung, heart, mediastinum, lymph nodes, extremity, and bone.
  • Intratumoral hemorrhage was indicated and preoperative diagnosis was cavernous angioma.

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  • (PMID = 16146213.001).
  • [ISSN] 0006-8969
  • [Journal-full-title] Nō to shinkei = Brain and nerve
  • [ISO-abbreviation] No To Shinkei
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 19
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50. Malagari K, Alexopoulou E, Dourakis S, Kelekis A, Hatzimichail K, Sissopoulos A, Delis S, Letsou D, Kelekis D: Transarterial embolization of giant liver hemangiomas associated with Kasabach-Merritt syndrome: a case report. Acta Radiol; 2007 Jul;48(6):608-12
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  • [Title] Transarterial embolization of giant liver hemangiomas associated with Kasabach-Merritt syndrome: a case report.
  • Of 22 patients with symptomatic giant liver hemangiomas referred for embolization, two females (52 and 74 years) had Kasabach-Merritt syndrome (KMS).
  • Hepatic angiography revealed excessive vascular lakes typical of cavernous hemangiomas.
  • Coil packing of the feeding hepatic artery was additionally used in one patient.
  • [MeSH-major] Blood Coagulation Disorders / therapy. Embolization, Therapeutic / methods. Hemangioma / complications. Hemangioma / therapy. Liver Neoplasms / complications. Liver Neoplasms / therapy
  • [MeSH-minor] Aged. Female. Fibrinogen. Follow-Up Studies. Hematocrit / methods. Hepatic Artery / radiography. Humans. Microspheres. Middle Aged. Platelet Count. Rare Diseases. Syndrome. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 17611866.001).
  • [ISSN] 0284-1851
  • [Journal-full-title] Acta radiologica (Stockholm, Sweden : 1987)
  • [ISO-abbreviation] Acta Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Sweden
  • [Chemical-registry-number] 9001-32-5 / Fibrinogen
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51. Chung EM, Cube R, Lewis RB, Conran RM: From the archives of the AFIP: Pediatric liver masses: radiologic-pathologic correlation part 1. Benign tumors. Radiographics; 2010 May;30(3):801-26
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  • [Title] From the archives of the AFIP: Pediatric liver masses: radiologic-pathologic correlation part 1. Benign tumors.
  • Benign hepatic tumors in children include lesions that are unique to the pediatric age group and others that are more common in adults.
  • Infantile hemangioendothelioma, or infantile hepatic hemangioma, is a benign vascular tumor that may cause serious clinical complications.
  • Mesenchymal hamartoma of the liver occurs in young children and is characterized pathologically by mesenchymal proliferation with fluid-containing cysts of varying size and number.
  • Benign epithelial tumors that are common in adults may infrequently occur in childhood.
  • All are composed of hyperplastic hepatocytes similar to surrounding liver parenchyma and may be difficult to discern at imaging.
  • Preferential hepatic arterial phase enhancement helps distinguish FNH and hepatic adenoma from uninvolved liver.
  • Hepatic adenoma often has intracellular fat and a propensity for intratumoral hemorrhage, neither of which are seen in FNH.
  • Knowledge of how the pathologic features of these tumors affect their imaging appearances helps radiologists offer an appropriate differential diagnosis and management plan.
  • [MeSH-major] Diagnostic Imaging / methods. Liver Neoplasms / diagnosis

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  • (PMID = 20462995.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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52. Miliaras D, Conroy J, Pervana S, Meditskou S, McQuaid D, Nowak N: Karyotypic changes detected by comparative genomic hybridization in a stillborn infant with chorioangioma and liver hemangioma. Birth Defects Res A Clin Mol Teratol; 2007 Mar;79(3):236-41
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  • [Title] Karyotypic changes detected by comparative genomic hybridization in a stillborn infant with chorioangioma and liver hemangioma.
  • BACKGROUND: Placental hemangioma (chorioangioma) and congenital hemangioma are relatively common tumors, which on rare occasions may occur together.
  • CASE: Herein we describe a rare case of a stillborn infant with chorioangioma, placental mesenchymal dysplasia, and liver cavernous hemangioma.
  • The chromosomal abnormalities that we found were deletions at 2q13 and 7p21.1 and were common to both placental and liver lesions.
  • CONCLUSIONS: None of the identified chromosomal aberrations have been previously associated with chorioangiomas or hemangiomas.
  • Important genes that lie in these DNA regions may be implicated in the pathogenesis of congenital hemangiomas and mesenchymal dysplasia.
  • [MeSH-major] Chromosome Aberrations. Hemangioma / genetics. Hemangioma, Cavernous / genetics. Liver Neoplasms / genetics. Placenta Diseases / genetics. Stillbirth / genetics

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  • (PMID = 17203486.001).
  • [ISSN] 1542-0752
  • [Journal-full-title] Birth defects research. Part A, Clinical and molecular teratology
  • [ISO-abbreviation] Birth Defects Res. Part A Clin. Mol. Teratol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA016056-30
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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53. Repiso A, Gómez Rodríguez R, González de Frutos C, de Artaza T, Sánchez Ruano JJ, Pérez Grueso MJ, Martínez Potenciano JL: [Angioma-like liver lesions in patients with chronic liver disease]. Rev Esp Enferm Dig; 2007 May;99(5):259-63
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  • [Title] [Angioma-like liver lesions in patients with chronic liver disease].
  • [Transliterated title] Lesiones hepáticas sugestivas de angioma en pacientes con hepatopatía crónica.
  • OBJECTIVE: The aim of this study was to evaluate in our healthcare area the clinical, ultrasonographic, and evolutionary features of patients with chronic liver disease and angioma-like liver lesions on ultrasonography.
  • Included in the study were patients that presented with clinical and/or laboratory complaints consistent with chronic liver disease of any etiology, and those in which abdominal ultrasounds revealed the existence of at least one angioma-like liver lesion.
  • RESULTS: In the course of our study, 58 patients were diagnosed with chronic liver disease and angioma-like liver lesions, of which 13 showed clinical, laboratory, ultrasonographic, and/or histological signs of liver cirrhosis.
  • In 50% of patients these lesions were less than 10 mm in diameter, and in most cases were located in the right hepatic lobe.
  • During an average follow-up period of 35 months (6-168 months) we verified that, in two patients, these lesions, initially interpreted as angiomas were in fact malignancies (one hepatocellular carcinoma and one metastatic adenocarcinoma of the gallbladder).
  • Thus, our study revealed that 15% of lesions found in cirrhotic patients initially interpreted as angiomas were actually malignant.
  • CONCLUSIONS: Our study revealed that, in patients with chronic liver disease, particularly in cirrhotic patients, a considerable percentage of ultrasonographic lesions originally interpreted as angiomas are in fact malignant tumors.
  • [MeSH-major] Hemangioma / ultrasonography. Liver Cirrhosis / ultrasonography. Liver Neoplasms / ultrasonography
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Chronic Disease. Female. Humans. Liver Diseases / ultrasonography. Male. Middle Aged. Retrospective Studies


54. Yamamoto K, Shiraki K, Nakanishi S, Fuke H, Hashimoto A, Shimizu A, Nakano T: The usefulness of 1.5 harmonic imaging ultrasonography with Levovist in the diagnosis of focal hepatic tumors. Int J Oncol; 2005 Oct;27(4):989-95
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  • [Title] The usefulness of 1.5 harmonic imaging ultrasonography with Levovist in the diagnosis of focal hepatic tumors.
  • In the present study, we investigated the usefulness of 1.5 harmonic imaging sonography with the use of the contrast agent Levovist for the diagnosis of hepatocellular carcinoma (HCC), metastatic hepatic tumor, and hepatic hemangioma.
  • The subjects in this study were 64 patients with 70 nodules of hepatic tumors (42 nodules in 36 cases of hepatocellular carcinoma, 20 nodules in 20 cases of metastatic hepatic tumor, and 8 nodules in 8 cases of hepatic hemangioma).
  • 1.5 harmonic imaging sonography of metastatic hepatic tumor showed hypervascular enhancement of the margin of 20 nodules (100%) in the early and portal phases, which changed to images with no contrast enhancement in the late phase.
  • 1.5 harmonic imaging sonography of hepatic hemangiomas maintained hypervascular enhancement on the tumor margin of 5 nodules (62.5%) in the early and portal phases.
  • 1.5 harmonic imaging sonography of hepatic tumors (hepatocellular carcinoma, metastatic hepatic tumor and hepatic hemangioma) provided characteristic findings of contrast enhancement in the early, portal, and late phases, and will contribute to differential diagnosis.
  • [MeSH-major] Carcinoma, Hepatocellular / diagnosis. Contrast Media / pharmacology. Hemangioma / diagnosis. Liver Neoplasms / diagnosis. Polysaccharides. Ultrasonography / methods
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Angiography. Carbon Dioxide / metabolism. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Neoplasm Metastasis

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  • (PMID = 16142315.001).
  • [ISSN] 1019-6439
  • [Journal-full-title] International journal of oncology
  • [ISO-abbreviation] Int. J. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Polysaccharides; 127279-08-7 / SHU 508; 142M471B3J / Carbon Dioxide
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55. Meguro M, Soejima Y, Taketomi A, Ikegami T, Yamashita Y, Harada N, Itoh S, Hirata K, Maehara Y: Living donor liver transplantation in a patient with giant hepatic hemangioma complicated by Kasabach-Merritt syndrome: report of a case. Surg Today; 2008;38(5):463-8
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  • [Title] Living donor liver transplantation in a patient with giant hepatic hemangioma complicated by Kasabach-Merritt syndrome: report of a case.
  • We herein present a case of unresectable giant hepatic hemangiomas with Kasabach-Merritt syndrome which was successfully treated by living donor liver transplantation using a left lobe graft.
  • The hepatic tumors were thus judged untreatable and the only option for a cure was to offer living donor liver transplantation, because of the tumor size, its location, and the association with Kasabach-Merritt syndrome.
  • A left lobe graft with the middle hepatic vein donated by her 47-year-old brother was transplanted under venovenous bypass.
  • In conclusion, living donor liver transplantation was found to be an effective option for the treatment of a patient with unresectable giant hepatic hemangiomas complicated by Kasabach-Merritt syndrome.
  • [MeSH-major] Disseminated Intravascular Coagulation / etiology. Hemangioma / surgery. Liver Neoplasms / surgery. Liver Transplantation. Living Donors


56. Limawararut V, Davis G, Crompton J, Leibovitch I, Selva D: Recurrent multiple cavernous hemangiomas of the orbit in association with systemic tumors. Am J Ophthalmol; 2006 May;141(5):943-5
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  • [Title] Recurrent multiple cavernous hemangiomas of the orbit in association with systemic tumors.
  • PURPOSE: To report the clinical findings and management of multiple, recurrent cavernous hemangiomas of the orbit in a patient with concurrent liver involvement.
  • RESULTS: A 35-year-old woman with blurry vision and proptosis was found to have multiple cavernous hemangiomas of the orbit.
  • Fifteen years later, the patient had recurrent, multiple cavernous hemangiomas in the same orbit.
  • Further investigations for vague back pain revealed a presumed cavernous hemangioma in the liver and a presumed schwannoma arising from the neural foramen of the spine at the level of T2 through T4.
  • CONCLUSION: Multiple cavernous hemangiomas may recur after complete excision and may exist with concurrent systemic tumors.
  • [MeSH-major] Hemangioma, Cavernous / pathology. Liver Neoplasms / pathology. Neoplasm Recurrence, Local / pathology. Neoplasms, Multiple Primary / pathology. Neurilemmoma / pathology. Orbital Neoplasms / pathology. Pleural Neoplasms / pathology

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  • (PMID = 16678512.001).
  • [ISSN] 0002-9394
  • [Journal-full-title] American journal of ophthalmology
  • [ISO-abbreviation] Am. J. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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57. Vasconcelos L, Silva S, Garcia A, Medeiros D, Albuquerque E Castro J, Capitão LM: [Visceral artery aneurysms: alternative therapeutic approach]. Rev Port Cir Cardiotorac Vasc; 2006 Jul-Sep;13(3):155-8
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  • Case number 2 was a 72 year-old woman with a past medical history significant for hepatic angioma and hypothyroidism.

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  • (PMID = 17057828.001).
  • [ISSN] 0873-7215
  • [Journal-full-title] Revista portuguesa de cirurgia cardio-torácica e vascular : órgão oficial da Sociedade Portuguesa de Cirurgia Cardio-Torácica e Vascular
  • [ISO-abbreviation] Rev Port Cir Cardiotorac Vasc
  • [Language] por
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Portugal
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58. Muthamilselvan S, Vinoth PN, Vilvanathan V, Ninan B, Amboiram P, Sai V, Anand V, Scott JX: Hepatic haemangioma of infancy: role of propranolol. Ann Trop Paediatr; 2010;30(4):335-8
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  • [Title] Hepatic haemangioma of infancy: role of propranolol.
  • A newborn girl with a haemangioma of the liver failed to respond to cortico-steroid therapy.
  • Ultrasonic evidence of the haemangioma disappeared after 2 months of treatment with propranolol.
  • [MeSH-major] Adrenergic beta-Antagonists / therapeutic use. Hemangioma / drug therapy. Infant, Premature, Diseases / drug therapy. Liver Neoplasms / drug therapy. Propranolol / therapeutic use

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  • (PMID = 21118629.001).
  • [ISSN] 1465-3281
  • [Journal-full-title] Annals of tropical paediatrics
  • [ISO-abbreviation] Ann Trop Paediatr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Adrenergic beta-Antagonists; 9Y8NXQ24VQ / Propranolol
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59. Han SL, Wu XL, Jia ZR, Wang PF: Adult hepatic cavernous haemangioma with highly elevated alpha-fetoprotein. Hong Kong Med J; 2010 Oct;16(5):400-2
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  • [Title] Adult hepatic cavernous haemangioma with highly elevated alpha-fetoprotein.
  • Laboratory examination revealed that his serum alpha-fetoprotein level was 1890 microg/L (reference range, 0-20 microg/L), and computed tomographic scan showed a hypodense lesion in the left liver lobe.
  • At laparotomy, a dark reddish soft tumour (3.0 x 3.5 cm in diameter) was found in the medial segment of the liver (segment III).
  • Intra-operative pathology and postoperative histopathology examinations revealed that the tumour was a cavernous haemangioma of the liver.
  • Clinicians should be aware that some rare tumours besides hepatocellular carcinoma and endodermal sinus tumours (yolk sac tumour), for example, hepatic haemangioma, can produce alpha-fetoprotein.

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  • (PMID = 20890007.001).
  • [ISSN] 1024-2708
  • [Journal-full-title] Hong Kong medical journal = Xianggang yi xue za zhi
  • [ISO-abbreviation] Hong Kong Med J
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / alpha-Fetoproteins
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60. Zenzen W, Perez-Atayde AR, Elisofon SA, Kim HB, Alomari AI: Hepatic failure in a rapidly involuting congenital hemangioma of the liver: failure of embolotherapy. Pediatr Radiol; 2009 Oct;39(10):1118-23
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  • [Title] Hepatic failure in a rapidly involuting congenital hemangioma of the liver: failure of embolotherapy.
  • We report the clinical course, imaging findings, and management of a rare case of rapidly involuting congenital hemangioma of the liver in a newborn girl.
  • The baby presented with severe progressive hepatic dysfunction and cardiomegaly.
  • Multimodality imaging demonstrated a large hypervascular solitary hepatic mass with marked transhepatic shunting, consistent with rapidly involuting congenital hemangioma.
  • Because medical therapy failed, transarterial and transvenous embolization was performed with the main intention to improve the hepatic perfusion and function.
  • Unfortunately, despite improvement in the cardiac overload, liver function continued to deteriorate.
  • The baby eventually underwent successful liver transplantation.
  • [MeSH-major] Embolization, Therapeutic / methods. Hemangioma / therapy. Liver Neoplasms / therapy
  • [MeSH-minor] Female. Humans. Infant, Newborn. Liver Failure / diagnosis. Liver Failure / etiology. Liver Failure / surgery. Liver Transplantation. Treatment Failure. Treatment Outcome

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  • [Cites] Acta Paediatr Taiwan. 2003 Jan-Feb;44(1):8-13 [12800377.001]
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  • (PMID = 19588131.001).
  • [ISSN] 1432-1998
  • [Journal-full-title] Pediatric radiology
  • [ISO-abbreviation] Pediatr Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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61. Lal H, Neyaz Z, Singh RK, Mohindra S: Vascular malformation of the jejunum presenting as obscure gastrointestinal haemorrhage: detection with multidetector CT angiography. Singapore Med J; 2010 Jun;51(6):e103-6
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  • Phlebectasia or venous ectasia is a rare benign vascular anomaly of the gastrointestinal tract.
  • We report a 39-year-old Egyptian man presenting with multiple jejunal phlebectasia, liver haemangioma and port-wine naevus.
  • This report emphasises the potential of MDCT angiography in the diagnosis of small intestine lesions presenting as obscure bleeding.
  • [MeSH-major] Gastrointestinal Hemorrhage / diagnosis. Jejunum / physiopathology. Tomography, X-Ray Computed / methods. Vascular Malformations / diagnosis
  • [MeSH-minor] Adult. Double-Balloon Enteroscopy / methods. Endoscopy / methods. Hemangioma / diagnosis. Humans. Male. Port-Wine Stain. Treatment Outcome

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  • (PMID = 20658097.001).
  • [ISSN] 0037-5675
  • [Journal-full-title] Singapore medical journal
  • [ISO-abbreviation] Singapore Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
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62. Abaalkhail F, Castonguay M, Driman DK, Parfitt J, Marotta P: Lobular capillary hemangioma of the liver. Hepatobiliary Pancreat Dis Int; 2009 Jun;8(3):323-5
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  • [Title] Lobular capillary hemangioma of the liver.
  • BACKGROUND: Lobular capillary hemangioma (LCH) is a benign vascular tumor that is rare in adults and has never been reported in the liver.
  • METHODS: LCH as a large asymptomatic hepatic mass was seen in a 35-year-old female.
  • RESULTS: A large vascular hepatic lesion was observed in an asymptomatic 35-year-old female.
  • CONCLUSIONS: This is the first case of lobular capillary hemangioma seen as a liver lesion in an adult.
  • Large vascular hepatic lesions pose significant difficulties in discerning benign from potentially malignant conditions.
  • In this report we describe the pitfalls and radiological uncertainties with interpreting vascular lesions of the liver.
  • [MeSH-major] Granuloma, Pyogenic / diagnosis. Liver Diseases / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging

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  • (PMID = 19502177.001).
  • [ISSN] 1499-3872
  • [Journal-full-title] Hepatobiliary & pancreatic diseases international : HBPD INT
  • [ISO-abbreviation] HBPD INT
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 6
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63. Hansen T, Habekost M, Flieger D, Kirkpatrick CJ: [Littoral cell angioma of the spleen. Association with colon and hepatocellular carcinoma]. Pathologe; 2010 Jul;31(4):290-2
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  • [Title] [Littoral cell angioma of the spleen. Association with colon and hepatocellular carcinoma].
  • [Transliterated title] Littoralzellangiom der Milz. Assoziation mit Kolon- und hepatozellulärem Karzinom.
  • Littoral cell angioma is a rare vascular tumor of the spleen.
  • Due to the relationship with malignant tumors littoral cell angioma should be considered in every case of a splenic tumoral space-occupying mass, particularly in carcinoma patients.
  • [MeSH-major] Adenocarcinoma / pathology. Carcinoma, Hepatocellular / pathology. Colonic Neoplasms / pathology. Hemangioma / pathology. Liver Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Splenic Neoplasms / pathology
  • [MeSH-minor] Aged. Antigens, CD / analysis. Antigens, CD31 / analysis. Antigens, Differentiation, Myelomonocytic / analysis. Biomarkers, Tumor / analysis. Colectomy. Colon / pathology. Hepatectomy. Humans. Liver / pathology. Male. Neoplasm Staging. Spleen / pathology. Splenectomy

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  • (PMID = 20349061.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD31; 0 / Antigens, Differentiation, Myelomonocytic; 0 / Biomarkers, Tumor; 0 / CD68 antigen, human
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64. Wan P, Susman J, Kandel J, Jan D, Jerome EH, Parravicini E: Neonatal hepatic mesenchymal hamartoma causing cardiac failure and disseminated intravascular coagulopathy. Am J Perinatol; 2009 Sep;26(8):601-4
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  • [Title] Neonatal hepatic mesenchymal hamartoma causing cardiac failure and disseminated intravascular coagulopathy.
  • Even with advance prenatal diagnostic tools, differentiating among specific types of hepatic masses continues to challenge many physicians.
  • Here, we report a neonate with life-threatening hepatic mass, cardiac failure, and disseminated intravascular coagulopathy, which clinically resembled hepatic hemangioma.
  • A hepatic mesenchymal hamartoma was detected by postmortem pathology.
  • [MeSH-major] Disseminated Intravascular Coagulation / etiology. Hamartoma / complications. Hamartoma / congenital. Heart Failure / etiology. Liver Diseases / complications. Liver Diseases / congenital

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  • [Copyright] Thieme Medical Publishers.
  • (PMID = 19370509.001).
  • [ISSN] 1098-8785
  • [Journal-full-title] American journal of perinatology
  • [ISO-abbreviation] Am J Perinatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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66. Maizlin ZV, Vos PM, Cooperberg PL: Is it a fibroid? Are you sure? Sonography with MRI assistance. Ultrasound Q; 2007 Mar;23(1):55-62
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  • Uterine fibroids are common benign lesions.
  • Other common benign masses include renal cysts, renal angiomyolipomas, hepatic cysts, hepatic hemangiomas, thyroid cysts, adrenal incidentalomas, pulmonary granulomas and hamartomas, ovarian cysts, and dermoids.
  • [MeSH-minor] Diagnosis, Differential. Female. Humans

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  • (PMID = 17558230.001).
  • [ISSN] 0894-8771
  • [Journal-full-title] Ultrasound quarterly
  • [ISO-abbreviation] Ultrasound Q
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 28
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67. Noda T, Sasaki Y, Yamada T, Eguchi H, Takachi K, Noura S, Miyashiro I, Murata K, Doki Y, Ohigashi H, Ishikawa O, Imaoka S, Mitani H, Ishiguro S: Adult capillary hemangioma of the liver: report of a case. Surg Today; 2005;35(9):796-9
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  • [Title] Adult capillary hemangioma of the liver: report of a case.
  • We report a rare case of capillary hemangioma of the liver in an adult.
  • The patient was a 55-year-old man, admitted for investigation of a hepatic tumor.
  • Computed tomography (CT) showed an enhancement pattern different from that of hepatocellular carcinoma (HCC) or cavernous hemangioma.
  • We could not establish whether the tumor was HCC or cavernous hemangioma by the imaging findings, so we performed a hepatic resection.
  • Histopathological examination confirmed a diagnosis of capillary hemangioma.
  • Ultrasonography, CT, and magnetic resonance imaging showed an intermediate pattern between cavernous hemangioma and HCC.
  • Thus, we must be aware of the possibility of capillary hemangioma when finding an atypical liver tumor inconsistent with HCC or cavernous hemangioma.
  • [MeSH-major] Hemangioma, Capillary / diagnosis. Hemangioma, Capillary / surgery. Liver Neoplasms / diagnosis. Liver Neoplasms / surgery
  • [MeSH-minor] Diagnosis, Differential. Diagnostic Imaging. Humans. Male. Middle Aged

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  • [Cites] Radiology. 1980 Oct;137(1 Pt 1):149-55 [7422836.001]
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  • (PMID = 16133680.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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68. Kadri Aribas B, Dingil G, Ungul U, Sahin G, Nil Unlu D, Dogan K, Simsek Z, Kaya G, Yilmaz K, Yucel E, Demir P: Accuracy and safety of percutaneous US-guided needle biopsies in liver metastasis and hemangiomas. Minerva Gastroenterol Dietol; 2010 Dec;56(4):377-82
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  • [Title] Accuracy and safety of percutaneous US-guided needle biopsies in liver metastasis and hemangiomas.
  • AIM: The aim of this study was to compare small size aspiration and large size cutting needles on the diagnostic yield in the biopsies of liver and especially to investigate the reliability on percutaneous biopsy of liver hemangiomas.
  • METHODS: Nine hundred fifty patients with percutaneous ultrasonography-guided liver biopsies were evaluated retrospectively.
  • Further evaluation was performed in 312 patients with metastasis and 48 patients with hemangiomas.
  • RESULTS: Diagnostic yield was higher in the large size cutting needle group (96.8%, 150/155) than in the small size aspiration needle group (84.1%, 132/157) in liver metastasis (P<0.001).
  • Accuracy rate was 77.9% (208/267) in benign and 89.5% (514/574) in malignant diseases.
  • CONCLUSION: The authors suggest the use of large size cutting needles, because they provide more accurate diagnosis, and should be used in liver metastasis instead of small aspiration needles, if there is no on-site pathologist at aspiration biopsies or a more specific diagnosis is required.
  • All the needles, including the large cutting type, were found safe in the biopsies of liver hemangiomas.
  • [MeSH-major] Biopsy, Fine-Needle / methods. Hemangioma / pathology. Liver Neoplasms / pathology. Ultrasonography, Interventional
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Predictive Value of Tests. Retrospective Studies. Sensitivity and Specificity

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  • (PMID = 21139536.001).
  • [ISSN] 1121-421X
  • [Journal-full-title] Minerva gastroenterologica e dietologica
  • [ISO-abbreviation] Minerva Gastroenterol Dietol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Italy
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69. Lin CH, Yu JC, Shih ML, Peng YJ, Hsieh CB: Littoral cell angioma of the spleen in a patient with hepatocellular carcinoma. J Formos Med Assoc; 2005 Apr;104(4):282-5
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  • [Title] Littoral cell angioma of the spleen in a patient with hepatocellular carcinoma.
  • Littoral cell angioma (LCA) is a rare primitive vascular tumor of the spleen which is benign and usually associated with visceral malignancy.
  • The diagnosis of LCA is based on histologic and immunohistologic analysis.
  • Dynamic computed tomography studies showed splenomegaly (20 cm in long axis) with a hypodense tumor in the upper pole and a contrast-enhanced hepatic mass in the right lobe of the liver.
  • Histopathology showed a moderately differentiated HCC of the liver and splenic angioma with dilated vascular channels lined by plump endothelial cells.

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  • (PMID = 15909068.001).
  • [ISSN] 0929-6646
  • [Journal-full-title] Journal of the Formosan Medical Association = Taiwan yi zhi
  • [ISO-abbreviation] J. Formos. Med. Assoc.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
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70. Yeh WC, Yang PM, Huang GT, Sheu JC, Chen DS: Long-term follow-up of hepatic hemangiomas by ultrasonography: with emphasis on the growth rate of the tumor. Hepatogastroenterology; 2007 Mar;54(74):475-9
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  • [Title] Long-term follow-up of hepatic hemangiomas by ultrasonography: with emphasis on the growth rate of the tumor.
  • BACKGROUND/AIMS: It is not rare to find hepatic hemangiomas in people in Taiwan where hepatitis B is endemic during ultrasonographic examinations for the screening of hepatocellular carcinoma, and we can therefore monitor these hemangiomas longitudinally since detected.
  • METHODOLOGY: Totally 180 hepatic hemangiomas in 130 adult patients were followed up for more than 5 years with at least twice ultrasound examinations in our hospital.
  • The diagnosis of hemangiomas was made by typical ultrasonographic findings as well as compatible findings in other imaging modalities.
  • The doubling time of tumor volume was calculated for the enlarging hepatic hemangiomas.
  • RESULTS: The diameters of the 180 hemangiomas ranged from <8 cm - >4 cm in 11 (6.1%), < or =4 cm - >2 cm in 55 (30.6%), and < or =2 cm in 114 (63.3%).
  • Among them, the diameter of 14 (7.7%) hemangiomas in 13 patients increased.
  • The tumor volume doubling time of these hemangiomas ranged from 17.3 to 178.1 months.
  • CONCLUSIONS: Although hepatic hemangiomas are benign, some of them indeed grow slowly.
  • The growth rates of these hemangiomas varied and were definitely slower as compared with those of malignant hepatic tumors.
  • [MeSH-major] Carcinoma, Hepatocellular / ultrasonography. Hemangioma / ultrasonography. Liver Neoplasms / ultrasonography. Neoplasms, Multiple Primary / ultrasonography

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  • (PMID = 17523302.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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71. Horii KA, Drolet BA, Baselga E, Frieden IJ, Metry DW, Morel KD, Newell BD, Nopper AJ, Garzon MC, Hemangioma Investigator Group: Risk of hepatic hemangiomas in infants with large hemangiomas. Arch Dermatol; 2010 Feb;146(2):201-3
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  • [Title] Risk of hepatic hemangiomas in infants with large hemangiomas.
  • [MeSH-major] Hemangioma / epidemiology. Hemangioma / pathology. Liver Neoplasms / epidemiology. Skin Neoplasms / pathology

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  • (PMID = 20157038.001).
  • [ISSN] 1538-3652
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Databank-accession-numbers] ClinicalTrials.gov/ NCT00374335
  • [Publication-type] Letter; Multicenter Study
  • [Publication-country] United States
  • [Investigator] Horii KA; Drolet BA; Baselga E; Frieden IJ; Metry DW; Morel KD; Newell BD; Nopper AJ; Garzon MC; Chamlin SL; Haggstrom AN; Lucky AW; Mancini AJ; Siegel D; Holland K; Powell J; McCuaig CM; Adams D
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72. Lanthaler M, Freund M, Nehoda H: Laparoscopic resection of a giant liver hemangioma. J Laparoendosc Adv Surg Tech A; 2005 Dec;15(6):624-6
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  • [Title] Laparoscopic resection of a giant liver hemangioma.
  • We present a case report of hepatic resection performed laparoscopically for a giant symptomatic hemangioma.
  • The patient was a 50-year-old woman who was diagnosed with a giant hemangioma 20 cm in diameter.
  • As in the case of our patient, laparoscopic resection of hepatic hemangiomas can be performed successfully, even when dealing with giant hemangiomas.
  • [MeSH-major] Hemangioma / surgery. Laparoscopy / methods. Liver Neoplasms / surgery

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  • (PMID = 16366871.001).
  • [ISSN] 1092-6429
  • [Journal-full-title] Journal of laparoendoscopic & advanced surgical techniques. Part A
  • [ISO-abbreviation] J Laparoendosc Adv Surg Tech A
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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73. Dong KR, Zheng S, Xiao X: Conservative management of neonatal hepatic hemangioma: a report from one institute. Pediatr Surg Int; 2009 Jun;25(6):493-8
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  • [Title] Conservative management of neonatal hepatic hemangioma: a report from one institute.
  • PURPOSE: To summarize the conservative treatment of neonatal hepatic hemangioma at one institute.
  • PATIENTS AND MATERIALS: Fifteen cases of neonatal hepatic hemangioma were managed in our hospital during the previous 5 years.
  • Initial symptoms, combination symptoms, diagnosis, and treatment were analyzed.
  • Combination symptoms were multiple skin hemangiomas, pneumonia, and cardiac insufficiency.
  • Ultrasound and CT showed the typical characteristics of the liver hemangioma.
  • There were three types of hepatic hemangioma: nine cases had a single focus, four cases were multiple foci, and two had diffuse changes in the liver.
  • One patient having multi-focus in the liver gave up the treatment after biopsy.
  • In those who received conservative therapy, all hemangiomas disappeared within 1 year.
  • CONCLUSION: The diagnosis of hepatic hemangioma can be made from symptomology, ultrasound, and CT; pathologic samples are not necessary.
  • Proactive therapy for congestive heart failure is helpful for those endangering liver hemangioma.
  • Surgery can increase the risk of complications and is not advised for treatment of neonatal hepatic hemangioma.
  • [MeSH-major] Hemangioma / diagnosis. Hemangioma / therapy. Liver Neoplasms / diagnosis. Liver Neoplasms / therapy

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  • (PMID = 19415303.001).
  • [ISSN] 1437-9813
  • [Journal-full-title] Pediatric surgery international
  • [ISO-abbreviation] Pediatr. Surg. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Glucocorticoids
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74. Losanoff JE, Millis JM: Liver hemangioma complicated by obstructive jaundice. Am J Surg; 2008 Sep;196(3):e3-4
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  • [Title] Liver hemangioma complicated by obstructive jaundice.
  • This report describes a liver hemangioma causing obstructive jaundice, an extremely rare condition that has been reported on 3 previous occasions.
  • A hemangioma can compress the major bile ducts and require partial hepatectomy for a successful outcome.
  • [MeSH-major] Hemangioma, Cavernous / complications. Jaundice, Obstructive / etiology. Liver Neoplasms / complications

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  • (PMID = 18519125.001).
  • [ISSN] 1879-1883
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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75. Ertan G, Tekes A, Mitchell S, Keefer J, Huisman TA: Pediatric littoral cell angioma of the spleen: multimodality imaging including diffusion-weighted imaging. Pediatr Radiol; 2009 Oct;39(10):1105-9
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  • [Title] Pediatric littoral cell angioma of the spleen: multimodality imaging including diffusion-weighted imaging.
  • Littoral cell angioma (LCA) is a rare primary splenic vascular tumor originating from littoral cells lining the splenic red pulp sinuses.
  • Previous studies on liver lesions have shown that DWI allows differentiation of vascular tumors from primary neoplasms and metastatic disease.
  • The current case indicates that increased ADC values within the splenic lesions suggest a vascular etiology, which might help narrow the differential diagnosis.
  • [MeSH-major] Diffusion Magnetic Resonance Imaging / methods. Hemangioma / diagnosis. Splenic Neoplasms / diagnosis. Tomography, X-Ray Computed / methods. Ultrasonography / methods


76. Cho SH, Lee JY, Han JK, Choi BI: Acoustic radiation force impulse elastography for the evaluation of focal solid hepatic lesions: preliminary findings. Ultrasound Med Biol; 2010 Feb;36(2):202-8
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  • [Title] Acoustic radiation force impulse elastography for the evaluation of focal solid hepatic lesions: preliminary findings.
  • This study was designed to investigate the potential usefulness of acoustic radiation force impulse (ARFI) elastography to evaluate focal solid hepatic lesions.
  • In total, 51 patients with 60 focal hepatic lesions, which included 17 hemangiomas, 25 hepatocellular carcinomas (HCCs), 15 metastases and three cholangiocarcinomas, underwent ARFI elastography.
  • The lesions were classified into three groups: Group I consisted of metastatic liver tumors and cholangiocarcinomas, group II consisted of HCCs and group III consisted of hemangiomas.
  • Shear wave velocity was obtained to quantify stiffness for 36 focal hepatic lesions: 11 hemangiomas, 17 HCCs and eight other malignant lesions.
  • On ARFI elastography images, group I tumors (n=18) appeared stiffer than the background liver for 13 lesions (72%), softer for two lesions and had identical stiffness in three lesions compared with the background liver.
  • For group II tumors (n=25), 13 lesions (52%) appeared stiffer than the liver, six lesions appeared softer than the liver and the remaining six lesions showed the same stiffness as the liver.
  • For group III tumors (n=17), six lesions (35%) appeared stiffer than the liver, seven lesions appeared softer and the remaining four lesions showed the same stiffness as the liver.
  • Images obtained with ARFI elastography provided additional qualitative information regarding the stiffness and tumor margin of liver tumors.
  • By measuring shear wave velocity, quantification of stiffness was made possible and showed the potential to differentiate malignant hepatic tumors from hepatic hemangiomas.
  • [MeSH-major] Elasticity Imaging Techniques. Liver Neoplasms / ultrasonography

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  • [Copyright] 2010 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20018432.001).
  • [ISSN] 1879-291X
  • [Journal-full-title] Ultrasound in medicine & biology
  • [ISO-abbreviation] Ultrasound Med Biol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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77. Colakoğlu O, Taşkiran B, Yazici N, Buyraç Z, Unsal B: Safety of biopsy in liver hemangiomas. Turk J Gastroenterol; 2005 Dec;16(4):220-3
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  • [Title] Safety of biopsy in liver hemangiomas.
  • Hemangiomas are the most common tumors of the liver.
  • In case of inconclusive radiologic features and a history of malignancy or underlying liver disease, liver biopsy is indicated.
  • Bleeding is the most feared complication of biopsy of hemangiomas due to its highly vascular structure.
  • In our clinic, we biopsied seven patients with suspected masses and they were diagnosed histopathologically afterwards as having hemangiomas.
  • Although the case number is too small to reach a definite conclusion, we think that our report deserves attention in showing that concerns about bleeding during biopsy of hemangiomas may be overstated.
  • [MeSH-major] Hemangioma / pathology. Liver Neoplasms / pathology
  • [MeSH-minor] Biopsy, Needle / methods. Diagnosis, Differential. Humans. Middle Aged

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  • (PMID = 16547852.001).
  • [ISSN] 1300-4948
  • [Journal-full-title] The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
  • [ISO-abbreviation] Turk J Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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78. Zincirkeser S, Celen ZY, Yilmaz M, Topalhan F, Sahin E: A false negative by planar scintigraphy liver hemangioma, diagnosed by technetium-99m-red blood cells and technetium-99m-sulfur colloid single photon emission tomography scan. Hell J Nucl Med; 2006 May-Aug;9(2):109-10
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  • [Title] A false negative by planar scintigraphy liver hemangioma, diagnosed by technetium-99m-red blood cells and technetium-99m-sulfur colloid single photon emission tomography scan.
  • Ultrasonography showed a 4.7 cm solid hepatic mass on the right lateral side of the right lobe of the liver.
  • The patient was then sent to the Nuclear Medicine Department of Gaziantep University for liver scan.
  • After injecting autologous red blood cells labeled with 740 MBq of technetium-99m ((99m)Tc-RBC), early and delayed anterior planar images of the liver showed no significant findings because of the right kidney shine through the liver.
  • Two days later, after injecting again 740 MBq of (99m)Tc-RBC, we performed a single photon emission tomography (SPET) scan but still this scan was nondiagnostic even in the delayed images of the liver.
  • Three days later, after the iv injection of 185 MBq of technetium-99m-sulphur colloid ((99m)Tc-SC), we observed in the delayed SPET images of the liver, a mismatch defect with decreased focal uptake of (99m)Tc-SC at 60 min while the uptake of (99m)Tc-RBC at the same area was normal or slightly increased.
  • A cavernous hemangioma was found, confirmed by histology.
  • In conclusion, the mismatch of the SPET delayed images between the (99m)Tc-RBC and the (99m)Tc-SC scans indicated that this procedure was effective for the diagnosis of liver cavernous hemangioma located in this unusual position.
  • [MeSH-major] Erythrocytes / radionuclide imaging. Hemangioma / radionuclide imaging. Liver Neoplasms / radionuclide imaging. Technetium. Technetium Tc 99m Sulfur Colloid. Tomography, Emission-Computed, Single-Photon / methods

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  • [CommentIn] Hell J Nucl Med. 2009 May-Aug;12(2):177-8 [19675879.001]
  • [CommentIn] Hell J Nucl Med. 2006 Sep-Dec;9(3):187 [17160164.001]
  • (PMID = 16894416.001).
  • [ISSN] 1790-5427
  • [Journal-full-title] Hellenic journal of nuclear medicine
  • [ISO-abbreviation] Hell J Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 556Q0P6PB1 / Technetium Tc 99m Sulfur Colloid; 7440-26-8 / Technetium
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79. Bozgeyik Z, Kocakoc E, Gul Y, Dagli AF: Evaluation of liver hemangiomas using three different b values on diffusion MR. Eur J Radiol; 2010 Sep;75(3):360-3
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  • [Title] Evaluation of liver hemangiomas using three different b values on diffusion MR.
  • PURPOSE: To determine which diffusion-weighted MR technique (i.e., b-100, b-600, b-1000 s/mm(2)) is most useful in depicting liver hemangiomas.
  • MATERIALS AND METHODS: Diffusion-weighed MR (DWMR) was performed for 61 hemangiomas in 32 patients.
  • ADCs were measured for each lesions and compared with normal liver parenchymal ADCs on different b values.
  • Hemangiomas were subdivided according to lesion size (less than 3 cm and 3 cm or greater).
  • Lower ADC values were obtained for higher b values in normal liver tissue and hemangiomas.
  • Although there is significant difference between normal liver tissue and hemangiomas; this is more apparent on b-1000 images (p=0.022 on b-100, p=0.003 on b-600, and p=0.000 on b-1000 images).
  • Variance analysis revealed hemangiomas had higher ADC values than normal liver tissue on b-1000 images.
  • CONCLUSION: Mean values for ADCs of hemangiomas were lower than ADCs of the normal liver except for b-1000 value.
  • Higher b values are useful for the differentiation between normal liver tissue and hemangiomas.
  • [MeSH-major] Diffusion Magnetic Resonance Imaging / methods. Hemangioma / diagnosis. Image Enhancement / methods. Liver Neoplasms / diagnosis

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  • [Copyright] Copyright © 2009 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 19481893.001).
  • [ISSN] 1872-7727
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] Ireland
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80. Gourgiotis S, Moustafellos P, Zavos A, Dimopoulos N, Vericouki C, Hadjiyannakis EI: Surgical treatment of hepatic haemangiomas: a 15-year experience. ANZ J Surg; 2006 Sep;76(9):792-5
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  • [Title] Surgical treatment of hepatic haemangiomas: a 15-year experience.
  • BACKGROUND: Hepatic haemangiomas are congenital vascular malformations.
  • They are the most common benign tumours of the liver and are often asymptomatic.
  • We present our experience over the last 15 years with the surgical management of 15 liver haemangiomas to clarify the safety and effectiveness of this treatment.
  • METHODS: There were 15 patients with hepatic haemangiomas who were surgically treated from 1990 to 2004.
  • Indications for the operation were spontaneous or traumatic rupture, consumption coagulopathy, rapid growth, abdominal pain and uncertain diagnosis.
  • Methods for diagnosis included ultrasonography, computed tomography scan, magnetic resonance imaging and selective hepatic arteriography or combinations of more than one technique.
  • CONCLUSION: The resection of the hepatic haemangioma is safe.
  • [MeSH-major] Hemangioma / surgery. Liver Neoplasms / surgery

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  • (PMID = 16922900.001).
  • [ISSN] 1445-1433
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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81. R Aglyamov S, R Skovoroda A, Xie H, Kim K, M Rubin J, O'Donnell M, W Wakefield T, Myers D, Y Emelianov S: Model-based reconstructive elasticity imaging using ultrasound. Int J Biomed Imaging; 2007;2007:35830
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  • The model-based approach is illustrated using two potential clinical applications: differentiation of liver hemangioma and staging of deep venous thrombosis.

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  • (PMID = 18256732.001).
  • [ISSN] 1687-4188
  • [Journal-full-title] International journal of biomedical imaging
  • [ISO-abbreviation] Int J Biomed Imaging
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / R01 HL068658
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1986825
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82. Lai HJ, Yu JC, Liu YC, Shih ML, Hsieh CB: Anterior approach for a symptomatic giant hepatic haemangioma (&gt;30 centimetre). ANZ J Surg; 2006 Sep;76(9):863-5
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  • [Title] Anterior approach for a symptomatic giant hepatic haemangioma (>30 centimetre).
  • [MeSH-major] Hemangioma / surgery. Hepatectomy / methods. Liver Neoplasms / surgery

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  • (PMID = 16922914.001).
  • [ISSN] 1445-1433
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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83. Yun JP, Miao J, Chen GG, Tian QH, Zhang CQ, Xiang J, Fu J, Lai PB: Increased expression of nucleophosmin/B23 in hepatocellular carcinoma and correlation with clinicopathological parameters. Br J Cancer; 2007 Feb 12;96(3):477-84
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  • In this study, we examined NPM expression in 103 paired cases of hepatocellular carcinoma (HCC), 12 cases of hepatic focal nodular hyperplasia, 17 cases of liver tissue adjacent to a hepatic haemangioma, and series of array tissues from normal human organs and malignancies using a monoclonal antibody against NPM and reverse transcription-PCR techniques, Western blot analysis, immunohistochemistry, and immunocytofluorescence.
  • Moreover, enhanced expression of NPM in HCC correlated with the level of PCNA (R(2)=0.5639) and with the clinical prognostic parameters such as serum alpha fetal protein level, tumour pathological grading, and liver cirrhosis (P<0.05).
  • [MeSH-major] Carcinoma, Hepatocellular / chemistry. Liver Neoplasms / chemistry. Nuclear Proteins / analysis

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  • (PMID = 17245342.001).
  • [ISSN] 0007-0920
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Nuclear Proteins; 0 / Proliferating Cell Nuclear Antigen; 117896-08-9 / nucleophosmin
  • [Other-IDs] NLM/ PMC2360035
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84. Inoue A, Okura Y, Kawashita I, Ito K, Matsunaga N, Sanada T, Akiyama M, Ishida T: [Development of comprehensive image processing technique for differential diagnosis of liver disease by using multi-modality images-pixel-based cross-correlation method using a profile-]. Nihon Hoshasen Gijutsu Gakkai Zasshi; 2009 Apr 20;65(4):438-50
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  • [Title] [Development of comprehensive image processing technique for differential diagnosis of liver disease by using multi-modality images-pixel-based cross-correlation method using a profile-].
  • In this scheme, the criteria of an attending radiologist for the differential diagnosis of liver cyst, hemangioma of liver, hepatocellular carcinoma, and metastatic liver cancer on magnetic resonance images with various sequences and CT images with and without contrast enhancement employ a cross-correlation coefficient.
  • This comprehensive image-processing technique could assist radiologists in the differential diagnosis of liver diseases.
  • [MeSH-major] Image Processing, Computer-Assisted / methods. Liver Diseases / diagnosis. Magnetic Resonance Imaging / methods. Tomography, Spiral Computed / methods
  • [MeSH-minor] Diagnosis, Differential. Humans

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  • (PMID = 19420828.001).
  • [ISSN] 0369-4305
  • [Journal-full-title] Nihon Hōshasen Gijutsu Gakkai zasshi
  • [ISO-abbreviation] Nihon Hoshasen Gijutsu Gakkai Zasshi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
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85. Su TH, Liu WL, Yu CJ, Huang GT: Unusual dyspnoea in a patient with liver cirrhosis. BMJ Case Rep; 2009;2009
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  • [Title] Unusual dyspnoea in a patient with liver cirrhosis.
  • A 66-year-old woman with hepatitis C related liver cirrhosis presented to our hospital for dyspnoea and cyanosis.
  • Tachypnoea, low grade fever, clubbed fingers, palmar erythaema, spider angioma, wheezing and severe hypoxaemia were found.
  • She was followed in our clinic for 3 years and her respiratory condition on home oxygen remained stable, as did the liver cirrhosis.

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  • (PMID = 21686887.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3027928
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91. Raynaud JJ, Béchade D, Desrame J, Algayres JP: [Corticotherapy and giant hemangioma of the liver. Return to the normal values of cytokines]. Gastroenterol Clin Biol; 2006 Jun-Jul;30(6-7):907-9
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  • [Title] [Corticotherapy and giant hemangioma of the liver. Return to the normal values of cytokines].
  • [Transliterated title] Corticothérapie et hémangiome géant du foie. Effets bénéfiques sur les symptômes et normalisation des cytokines.
  • We report the case of a 36 year-old woman presenting with a giant liver hemangioma revealed by febrile hepatomegaly and weight loss.
  • Clinical and radiological follow-up, for respectively 36 and 24 months, did not show any relapse of symptoms or evolution of the hemangioma.
  • [MeSH-major] Anti-Inflammatory Agents / therapeutic use. Cytokines / blood. Glucocorticoids / therapeutic use. Hemangioma / drug therapy. Liver Neoplasms / drug therapy. Prednisone / therapeutic use
  • [MeSH-minor] Adult. Biopsy. Female. Humans. Interleukin-1 / blood. Interleukin-6 / blood. Liver / pathology. Magnetic Resonance Imaging. Time Factors. Tomography, X-Ray Computed. Treatment Outcome. Tumor Necrosis Factor-alpha / analysis

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  • (PMID = 16885878.001).
  • [ISSN] 0399-8320
  • [Journal-full-title] Gastroentérologie clinique et biologique
  • [ISO-abbreviation] Gastroenterol. Clin. Biol.
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 0 / Cytokines; 0 / Glucocorticoids; 0 / Interleukin-1; 0 / Interleukin-6; 0 / Tumor Necrosis Factor-alpha; VB0R961HZT / Prednisone
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92. Yilmaz-Cankaya B, Kantarci M, Durur-Karakaya A, Yalcin A: Giant hepatic hemangioma. Eurasian J Med; 2009 Apr;41(1):74
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  • [Title] Giant hepatic hemangioma.

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  • (PMID = 25610071.001).
  • [ISSN] 1308-8734
  • [Journal-full-title] The Eurasian journal of medicine
  • [ISO-abbreviation] Eurasian J Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Turkey
  • [Other-IDs] NLM/ PMC4261654
  • [Keywords] NOTNLM ; Giant / MDCT Imaging / hepatic hemangioma
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93. Isaacs H Jr: Fetal hydrops associated with tumors. Am J Perinatol; 2008 Jan;25(1):43-68
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  • Leukemia and extracardiac teratomas were next in frequency followed by hepatic tumors, neuroblastoma, placental, soft tissue, and renal tumors.
  • No fetus with the diagnosis of cardiac rhabdomyoma, neuroblastoma, brain tumor, rhabdoid tumor, or histiocytosis associated with hydrops survived.
  • Those patients with placental chorangioma, pericardial teratoma, and hepatic hemangioma had the best outcome.

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  • (PMID = 18075961.001).
  • [ISSN] 0735-1631
  • [Journal-full-title] American journal of perinatology
  • [ISO-abbreviation] Am J Perinatol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 144
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94. Hida T, Nishie A, Tajima T, Taketomi A, Aishima S, Honda H: Sclerosed hemangioma of the liver: possible diagnostic value of diffusion-weighted magnetic resonance imaging. Jpn J Radiol; 2010 Apr;28(3):235-8
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  • [Title] Sclerosed hemangioma of the liver: possible diagnostic value of diffusion-weighted magnetic resonance imaging.
  • We present a case of a sclerosed hemangioma (SH) of the liver that showed a high apparent diffusion coefficient (ADC) value.
  • The patient was undergoing preoperative evaluation for a metastatic breast cancer lesion when a liver mass with a diameter of 3 cm was found.
  • Liver metastasis and cholangiocellular carcinoma could not be excluded based on the imaging findings.
  • After surgery, a definite diagnosis of SH was obtained.
  • We discuss the diagnostic value of diffusion-weighted imaging for SH of the liver.
  • [MeSH-major] Diffusion Magnetic Resonance Imaging. Hemangioma / diagnosis. Liver Neoplasms / diagnosis
  • [MeSH-minor] Aged. Breast Neoplasms / diagnosis. Breast Neoplasms / pathology. Carcinoma, Ductal, Breast / diagnosis. Diagnosis, Differential. Female. Humans. Neoplasms, Multiple Primary / diagnosis

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  • (PMID = 20437137.001).
  • [ISSN] 1867-108X
  • [Journal-full-title] Japanese journal of radiology
  • [ISO-abbreviation] Jpn J Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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95. Zhou HB, Xu QR, Wang H, Zhou DX, Wang H, Wang Q, Zhou SS, Tu QQ, Sun ZQ, Ai L, Wu MC, Hu HP: [Risk factors of intrahepatic cholangiocarcinoma: a case-control study]. Zhonghua Gan Zang Bing Za Zhi; 2009 Dec;17(12):935-9
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  • RESULTS: Univariate analysis showed significant difference in HBsAg seropositivity, liver cirrhosis, hepatolithiasis, choledocholithiasis and schistosomiasis between ICC patients and healthy controls (P < 0.05).
  • Multivariate analysis confirmed that HBsAg seropositivity, liver cirrhosis, hepatolithiasis and hepatic schistosomiasis were associated with ICC, and their adjusted odds ratio (95% confidence interval) were 10.265 (6.676-15.783), 13.101 (5.265-32.604), 18.242 (3.580-92.958), 18.435 (1.930-176.082), 15.102 (4.607-49.499) and 11.820 (3.522-39.668), respectively.
  • The incidence of hepatic cyst, cholecystolithiasis, hepatic hemangioma, fatty liver, diabetes mellitus, smoking and drinking were not significantly different between ICC patients and controls.
  • CONCLUSIONS: The HBV infection, liver cirrhosis, hepatolithiasis and hepatic schistosomiasis may be the risk factors for ICC in China.
  • [MeSH-minor] Adult. Aged. Case-Control Studies. Female. Hepatitis B Surface Antigens / blood. Hepatitis B e Antigens / blood. Humans. Liver Cirrhosis / complications. Liver Cirrhosis / epidemiology. Liver Diseases / complications. Liver Diseases / epidemiology. Logistic Models. Male. Middle Aged. Odds Ratio. Risk Factors

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  • (PMID = 20038337.001).
  • [ISSN] 1007-3418
  • [Journal-full-title] Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology
  • [ISO-abbreviation] Zhonghua Gan Zang Bing Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Hepatitis B Surface Antigens; 0 / Hepatitis B e Antigens
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96. Markiewicz-Kijewska M, Kasprzyk W, Broniszczak D, Bacewicz L, Ostoja-Chyzynska A, Ismail H, Kosciesza A, Dembowska-Baginska B, Teisseyre J, Kluge P, Brzezinska-Rajszys G, Jankowska I, Kalicinski P: Hemodynamic failure as an indication to urgent liver transplantation in infants with giant hepatic hemangiomas or vascular malformations--report of four cases. Pediatr Transplant; 2009 Nov;13(7):906-12
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  • [Title] Hemodynamic failure as an indication to urgent liver transplantation in infants with giant hepatic hemangiomas or vascular malformations--report of four cases.
  • The aim of this study was to present acute hemodynamic failure as a rare indication for liver transplantation in neonates and infants with liver hemangiomatosis.
  • We report four patients aged one to six months with giant liver hemangiomas, with huge arterio-venous shunting within these malformations.
  • In three, many skin hemangiomas were found.
  • Two children underwent rescue hepatic artery surgical ligation, which did not prevent heart and then multiorgan failure including liver failure.
  • After unsuccessful conventional therapy, all infants were considered for urgent liver transplantation; in three cases, it was performed with a living-related donor, and in one case with a deceased donor.
  • Liver transplantation should be considered as a rescue treatment in children with hepatic vascular malformations leading to hemodynamic insufficiency when conventional therapy is unsuccessful and multiorgan failure develops.
  • [MeSH-major] Hemangioma / surgery. Liver Diseases / therapy. Liver Transplantation / methods. Vascular Malformations / surgery


97. Hyun W, Gamo M, Hirose Y: [Anesthetic management of a patient with Osler-Weber-Rendu disease undergoing mitral valvuloplasty]. Masui; 2008 Feb;57(2):223-5
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  • The patient was a 79-year-old woman admitted to our hospital with diagnosis of heart failure, mitral regurgitation, and chronic atrial fibrillation.
  • Preoperaitve examination revealed moderate mitral regurgitation with prolapsed anterior leaflet, pulmonary hypertension, high cardiac output (6.85 l min(-1)), and multiple hepatic angiomas.

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  • (PMID = 18277578.001).
  • [ISSN] 0021-4892
  • [Journal-full-title] Masui. The Japanese journal of anesthesiology
  • [ISO-abbreviation] Masui
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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98. Vossen JA, Buijs M, Liapi E, Eng J, Bluemke DA, Kamel IR: Receiver operating characteristic analysis of diffusion-weighted magnetic resonance imaging in differentiating hepatic hemangioma from other hypervascular liver lesions. J Comput Assist Tomogr; 2008 Sep-Oct;32(5):750-6
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  • [Title] Receiver operating characteristic analysis of diffusion-weighted magnetic resonance imaging in differentiating hepatic hemangioma from other hypervascular liver lesions.
  • PURPOSE: To evaluate the role of diffusion-weighted imaging in differentiating between hepatic hemangiomas, both typical and atypical, and other hypervascular liver lesions.
  • METHODS: Retrospective review of 182 hypervascular liver lesions in 117 patients was performed.
  • Receiver operating characteristic analysis was used to determine the accuracy of diffusion-weighted imaging in differentiating hemangiomas from other hypervascular liver lesions.
  • RESULTS: Lesions included typical and atypical hemangioma (n = 38), hepatocellular carcinoma (HCC; n = 58), focal nodular hyperplasia (FNH; n = 22), and neuroendocrine tumor metastasis (NET; n = 64) with a mean tumor size of 5.3 cm.
  • Mean ADC value for hemangioma, HCC, FNH, and NET was 2.29 x 10(-3), 1.55 x 10(-3), 1.65 x 10(-3), and 1.43 x 10(-3) mm2/s, respectively.
  • There was a statistically significant difference in the ADC value of hemangioma compared with that of FNH (P < 0.001), HCC (P < 0.001), and NET (P < 0.001), respectively.
  • CONCLUSIONS: Diffusion-weighted magnetic resonance imaging and ADC maps can provide rapid quantifiable information to differentiate typical and atypical hemangiomas from other hypervascular liver lesions.

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  • (PMID = 18830105.001).
  • [ISSN] 1532-3145
  • [Journal-full-title] Journal of computer assisted tomography
  • [ISO-abbreviation] J Comput Assist Tomogr
  • [Language] ENG
  • [Grant] United States / NIBIB NIH HHS / EB / EB006351-03; United States / NIBIB NIH HHS / EB / T32 EB006351; United States / NIBIB NIH HHS / EB / T32 EB006351-03
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS139195; NLM/ PMC2760589
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99. Sarialioglu F, Erbay A, Demir S: Response of infantile hepatic hemangioma to propranolol resistant to high-dose methylprednisolone and interferon-α therapy. Pediatr Blood Cancer; 2010 Dec 15;55(7):1433-4
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  • [Title] Response of infantile hepatic hemangioma to propranolol resistant to high-dose methylprednisolone and interferon-α therapy.
  • [MeSH-major] Drug Resistance, Neoplasm. Hemangioendothelioma / drug therapy. Interferon-alpha / administration & dosage. Liver Neoplasms / drug therapy. Methylprednisolone / administration & dosage. Propranolol / therapeutic use

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  • (PMID = 20981697.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Interferon-alpha; 9Y8NXQ24VQ / Propranolol; X4W7ZR7023 / Methylprednisolone
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100. Luo SM, Tan WM, Deng WX, Zhuang SM, Luo JW: Expression of albumin, IGF-1, IGFBP-3 in tumor tissues and adjacent non-tumor tissues of hepatocellular carcinoma patients with cirrhosis. World J Gastroenterol; 2005 Jul 21;11(27):4272-6
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  • ALB mRNA, IGF-1 mRNA, and IGFBP-3 mRNA in liver tissues (including tumor tissues and adjacent non-tumor tissues) were detected by reverse transcriptase-polymerase chain reaction (RT-PCR).
  • Liver Ki67 immunohistochemistry staining was studied.
  • At the same time, 12 patients with cholelithiasis or liver angioma who underwent operation were segregated as normal control.
  • RESULTS: In HCC patients with cirrhosis, hepatic ALB mRNA, IGF-1 mRNA, and IGFBP-3 mRNA of tumor tissues or adjacent non-tumor tissues were lower than the normal liver tissues, while in tumor tissues, hepatic ALB mRNA and IGFBP-3 mRNA were lower, hepatic IGF-1 mRNA was higher than in adjacent non-tumor tissues.
  • Liver Ki67 labeling index (Ki67 LI) in tumor tissues or adjacent non-tumor tissues were higher than that in the normal liver tissues, while in tumor tissues it was higher than that in adjacent non-tumor tissues.
  • CONCLUSION: Imbalance of IGF-1 and IGFBP-3 may play a role in hepatocarcinogenesis and tumor development of liver cirrhosis patients.
  • [MeSH-major] Albumins / genetics. Carcinoma, Hepatocellular / physiopathology. Insulin-Like Growth Factor Binding Protein 3 / genetics. Insulin-Like Growth Factor I / genetics. Liver Neoplasms / physiopathology
  • [MeSH-minor] Gene Expression Regulation, Neoplastic. Humans. Liver Cirrhosis / genetics. Liver Cirrhosis / physiopathology

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  • (PMID = 16015705.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Albumins; 0 / Insulin-Like Growth Factor Binding Protein 3; 67763-96-6 / Insulin-Like Growth Factor I
  • [Other-IDs] NLM/ PMC4615458
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