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6. Jang HJ, Kim TK, Wilson SR: Small nodules (1-2 cm) in liver cirrhosis: characterization with contrast-enhanced ultrasound. Eur J Radiol; 2009 Dec;72(3):418-24
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  • [Title] Small nodules (1-2 cm) in liver cirrhosis: characterization with contrast-enhanced ultrasound.
  • OBJECTIVE: To determine the diagnostic efficacy of arterial phase contrast-enhanced ultrasound (CEUS) for characterizing small hepatic nodules (1-2 cm) in patients with high-risk for hepatocellular carcinoma (HCC).
  • MATERIALS AND METHODS: Over 12 months, CEUS was performed in 59 patients at high-risk for HCC with small hepatic nodules (1-2 cm; mean, 1.5 cm).
  • Based only on arterial phase (<45 s) vascular intensity and pattern, lesions were prospectively diagnosed as HCC if there was hypervascularity without known features of hemangioma.
  • The diagnosis of HCC was made regardless of the presence or absence of washout.
  • Verification of diagnosis was made by liver transplantation (n=13), biopsy (n=12), resection (n=3) or clinical and imaging follow-up for at least 12 months (n=31).
  • RESULTS: At of the time of CEUS, the 59 nodules were diagnosed as HCC in 26 and benign lesions in 33, including 20 regenerative/dysplastic nodules (RN/DN), 11 hemangiomas, and 2 focal fat sparing.
  • All 26 nodules with arterial phase hypervascularity without hemangioma-like features were HCC.
  • CEUS correctly diagnosed all 11 hemangiomas.
  • CONCLUSIONS: Arterial phase vascular intensity and pattern of CEUS are highly accurate for the diagnosis of small (1-2 cm) HCC and hemangioma in liver cirrhosis.
  • On CEUS, arterial phase hypervascularity without a hemangioma-pattern alone may be sufficient for diagnosis of small HCC.
  • [MeSH-major] Carcinoma, Hepatocellular / ultrasonography. Fluorocarbons. Image Enhancement / methods. Liver Cirrhosis / ultrasonography. Liver Neoplasms / ultrasonography

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  • (PMID = 18834687.001).
  • [ISSN] 1872-7727
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Definity; 0 / Fluorocarbons
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7. Oto A, Kulkarni K, Nishikawa R, Baron RL: Contrast enhancement of hepatic hemangiomas on multiphase MDCT: Can we diagnose hepatic hemangiomas by comparing enhancement with blood pool? AJR Am J Roentgenol; 2010 Aug;195(2):381-6
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  • [Title] Contrast enhancement of hepatic hemangiomas on multiphase MDCT: Can we diagnose hepatic hemangiomas by comparing enhancement with blood pool?
  • OBJECTIVE: The purpose of this article is to determine whether enhancement of nodular foci within hemangiomas is homogeneous and matches blood vessels at different phases on contrast-enhanced MDCT.
  • MATERIALS AND METHODS: Multiphase (unenhanced, arterial, portal venous, and delayed phases) MDCT images of 58 hemangiomas were reviewed by two radiologists.
  • Nodular-enhancing foci within hemangiomas were evaluated for enhancement pattern and were subjectively compared with enhancement of the aorta, inferior vena cava, hepatic vein, and portal vein for each contrast-enhanced phase.
  • RESULTS: Qualitative analysis showed heterogeneously enhancing nodules in 79.3% and 65.5% of hemangiomas in the arterial phase and in 74.1% and 53.4% of hemangiomas in the portal venous phase, according to readers 1 and 2, respectively.
  • In the portal venous phase, 15.4% and 21.7%, 16.8% and 18.2%, 14.1% and 23.8%, and 19.5% and 25.9% of nodules were scored with enhancement similar to that in the aorta, inferior vena cava, hepatic vein, and portal vein by readers 1 and 2, respectively.
  • CONCLUSION: Attenuation of enhancing foci within hemangiomas does not match vessel density qualitatively or quantitatively.
  • Although persistent enhancement without washout is a useful CT criterion, specific criteria to match the blood pool cannot be used to confirm a diagnosis of hemangioma.
  • [MeSH-major] Hemangioma / radiography. Liver Neoplasms / radiography. Tomography, X-Ray Computed / methods

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  • (PMID = 20651193.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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8. Shimada K, Nakamoto Y, Isoda H, Saito H, Arizono S, Shibata T, Togashi K: FDG PET for giant cavernous hemangioma: important clue to differentiate from a malignant vascular tumor in the liver. Clin Nucl Med; 2010 Dec;35(12):924-6
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  • [Title] FDG PET for giant cavernous hemangioma: important clue to differentiate from a malignant vascular tumor in the liver.
  • Giant cavernous hemangioma of the liver sometimes has a very inhomogeneous appearance with intratumoral degeneration on computed tomography or magnetic resonance imaging, and may mimic a malignant hepatic tumor, including angiosarcoma.
  • There are many reports about F-18 fluorodeoxyglucose (FDG) uptake of angiosarcoma; however, knowledge regarding positron emission tomography findings with FDG for giant hepatic cavernous hemangioma is still limited.
  • We herein present 2 cases of giant hepatic cavernous hemangioma in which low FDG uptake was considered helpful to differentiate from malignant hepatic tumor.
  • [MeSH-major] Fluorodeoxyglucose F18. Hemangioma, Cavernous / radionuclide imaging. Liver Neoplasms / radionuclide imaging. Positron-Emission Tomography
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Middle Aged

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  • (PMID = 21206221.001).
  • [ISSN] 1536-0229
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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9. Masui T, Katayama M, Nakagawara M, Shimizu S, Kojima K: Exophytic giant cavernous hemangioma of the liver with growing tendency. Radiat Med; 2005 Mar;23(2):121-4
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  • [Title] Exophytic giant cavernous hemangioma of the liver with growing tendency.
  • Hepatic hemangioma is a common benign tumor, but its exophytic and expansile forms may be atypical.
  • We report a case of exophytic hemangioma of the liver with a growing tendency, demonstrated using magnetic resonance imaging (MRI) and computed tomography (CT) combined with angiography.
  • [MeSH-major] Hemangioma, Cavernous / diagnosis. Liver Neoplasms / diagnosis

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  • (PMID = 15827530.001).
  • [ISSN] 0288-2043
  • [Journal-full-title] Radiation medicine
  • [ISO-abbreviation] Radiat Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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10. Sylvestre VT, Dunton CJ: Treatment of recurrent endometrial stromal sarcoma with letrozole: a case report and literature review. Horm Cancer; 2010 Apr;1(2):112-5
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  • She had a computed tomography that showed a pelvic mass, an enlarged right internal iliac lymph node, an atypical liver hemangioma, and a severe left hydronephrosis.

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  • (PMID = 21761354.001).
  • [ISSN] 1868-8500
  • [Journal-full-title] Hormones & cancer
  • [ISO-abbreviation] Horm Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Hormonal; 0 / Aromatase Inhibitors; 0 / Nitriles; 0 / Triazoles; 7LKK855W8I / letrozole
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56. Limawararut V, Davis G, Crompton J, Leibovitch I, Selva D: Recurrent multiple cavernous hemangiomas of the orbit in association with systemic tumors. Am J Ophthalmol; 2006 May;141(5):943-5
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  • [Title] Recurrent multiple cavernous hemangiomas of the orbit in association with systemic tumors.
  • PURPOSE: To report the clinical findings and management of multiple, recurrent cavernous hemangiomas of the orbit in a patient with concurrent liver involvement.
  • RESULTS: A 35-year-old woman with blurry vision and proptosis was found to have multiple cavernous hemangiomas of the orbit.
  • Fifteen years later, the patient had recurrent, multiple cavernous hemangiomas in the same orbit.
  • Further investigations for vague back pain revealed a presumed cavernous hemangioma in the liver and a presumed schwannoma arising from the neural foramen of the spine at the level of T2 through T4.
  • CONCLUSION: Multiple cavernous hemangiomas may recur after complete excision and may exist with concurrent systemic tumors.
  • [MeSH-major] Hemangioma, Cavernous / pathology. Liver Neoplasms / pathology. Neoplasm Recurrence, Local / pathology. Neoplasms, Multiple Primary / pathology. Neurilemmoma / pathology. Orbital Neoplasms / pathology. Pleural Neoplasms / pathology

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  • (PMID = 16678512.001).
  • [ISSN] 0002-9394
  • [Journal-full-title] American journal of ophthalmology
  • [ISO-abbreviation] Am. J. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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57. Vasconcelos L, Silva S, Garcia A, Medeiros D, Albuquerque E Castro J, Capitão LM: [Visceral artery aneurysms: alternative therapeutic approach]. Rev Port Cir Cardiotorac Vasc; 2006 Jul-Sep;13(3):155-8
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  • Case number 2 was a 72 year-old woman with a past medical history significant for hepatic angioma and hypothyroidism.

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  • (PMID = 17057828.001).
  • [ISSN] 0873-7215
  • [Journal-full-title] Revista portuguesa de cirurgia cardio-torácica e vascular : órgão oficial da Sociedade Portuguesa de Cirurgia Cardio-Torácica e Vascular
  • [ISO-abbreviation] Rev Port Cir Cardiotorac Vasc
  • [Language] por
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Portugal
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58. Muthamilselvan S, Vinoth PN, Vilvanathan V, Ninan B, Amboiram P, Sai V, Anand V, Scott JX: Hepatic haemangioma of infancy: role of propranolol. Ann Trop Paediatr; 2010;30(4):335-8
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  • [Title] Hepatic haemangioma of infancy: role of propranolol.
  • A newborn girl with a haemangioma of the liver failed to respond to cortico-steroid therapy.
  • Ultrasonic evidence of the haemangioma disappeared after 2 months of treatment with propranolol.
  • [MeSH-major] Adrenergic beta-Antagonists / therapeutic use. Hemangioma / drug therapy. Infant, Premature, Diseases / drug therapy. Liver Neoplasms / drug therapy. Propranolol / therapeutic use

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  • (PMID = 21118629.001).
  • [ISSN] 1465-3281
  • [Journal-full-title] Annals of tropical paediatrics
  • [ISO-abbreviation] Ann Trop Paediatr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Adrenergic beta-Antagonists; 9Y8NXQ24VQ / Propranolol
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59. Han SL, Wu XL, Jia ZR, Wang PF: Adult hepatic cavernous haemangioma with highly elevated alpha-fetoprotein. Hong Kong Med J; 2010 Oct;16(5):400-2
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  • [Title] Adult hepatic cavernous haemangioma with highly elevated alpha-fetoprotein.
  • Laboratory examination revealed that his serum alpha-fetoprotein level was 1890 microg/L (reference range, 0-20 microg/L), and computed tomographic scan showed a hypodense lesion in the left liver lobe.
  • At laparotomy, a dark reddish soft tumour (3.0 x 3.5 cm in diameter) was found in the medial segment of the liver (segment III).
  • Intra-operative pathology and postoperative histopathology examinations revealed that the tumour was a cavernous haemangioma of the liver.
  • Clinicians should be aware that some rare tumours besides hepatocellular carcinoma and endodermal sinus tumours (yolk sac tumour), for example, hepatic haemangioma, can produce alpha-fetoprotein.

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  • (PMID = 20890007.001).
  • [ISSN] 1024-2708
  • [Journal-full-title] Hong Kong medical journal = Xianggang yi xue za zhi
  • [ISO-abbreviation] Hong Kong Med J
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / alpha-Fetoproteins
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60. Zenzen W, Perez-Atayde AR, Elisofon SA, Kim HB, Alomari AI: Hepatic failure in a rapidly involuting congenital hemangioma of the liver: failure of embolotherapy. Pediatr Radiol; 2009 Oct;39(10):1118-23
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  • [Title] Hepatic failure in a rapidly involuting congenital hemangioma of the liver: failure of embolotherapy.
  • We report the clinical course, imaging findings, and management of a rare case of rapidly involuting congenital hemangioma of the liver in a newborn girl.
  • The baby presented with severe progressive hepatic dysfunction and cardiomegaly.
  • Multimodality imaging demonstrated a large hypervascular solitary hepatic mass with marked transhepatic shunting, consistent with rapidly involuting congenital hemangioma.
  • Because medical therapy failed, transarterial and transvenous embolization was performed with the main intention to improve the hepatic perfusion and function.
  • Unfortunately, despite improvement in the cardiac overload, liver function continued to deteriorate.
  • The baby eventually underwent successful liver transplantation.
  • [MeSH-major] Embolization, Therapeutic / methods. Hemangioma / therapy. Liver Neoplasms / therapy
  • [MeSH-minor] Female. Humans. Infant, Newborn. Liver Failure / diagnosis. Liver Failure / etiology. Liver Failure / surgery. Liver Transplantation. Treatment Failure. Treatment Outcome

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  • (PMID = 19588131.001).
  • [ISSN] 1432-1998
  • [Journal-full-title] Pediatric radiology
  • [ISO-abbreviation] Pediatr Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
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61. Lal H, Neyaz Z, Singh RK, Mohindra S: Vascular malformation of the jejunum presenting as obscure gastrointestinal haemorrhage: detection with multidetector CT angiography. Singapore Med J; 2010 Jun;51(6):e103-6
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  • Phlebectasia or venous ectasia is a rare benign vascular anomaly of the gastrointestinal tract.
  • We report a 39-year-old Egyptian man presenting with multiple jejunal phlebectasia, liver haemangioma and port-wine naevus.
  • This report emphasises the potential of MDCT angiography in the diagnosis of small intestine lesions presenting as obscure bleeding.
  • [MeSH-major] Gastrointestinal Hemorrhage / diagnosis. Jejunum / physiopathology. Tomography, X-Ray Computed / methods. Vascular Malformations / diagnosis
  • [MeSH-minor] Adult. Double-Balloon Enteroscopy / methods. Endoscopy / methods. Hemangioma / diagnosis. Humans. Male. Port-Wine Stain. Treatment Outcome

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  • (PMID = 20658097.001).
  • [ISSN] 0037-5675
  • [Journal-full-title] Singapore medical journal
  • [ISO-abbreviation] Singapore Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
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62. Abaalkhail F, Castonguay M, Driman DK, Parfitt J, Marotta P: Lobular capillary hemangioma of the liver. Hepatobiliary Pancreat Dis Int; 2009 Jun;8(3):323-5
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  • [Title] Lobular capillary hemangioma of the liver.
  • BACKGROUND: Lobular capillary hemangioma (LCH) is a benign vascular tumor that is rare in adults and has never been reported in the liver.
  • METHODS: LCH as a large asymptomatic hepatic mass was seen in a 35-year-old female.
  • RESULTS: A large vascular hepatic lesion was observed in an asymptomatic 35-year-old female.
  • CONCLUSIONS: This is the first case of lobular capillary hemangioma seen as a liver lesion in an adult.
  • Large vascular hepatic lesions pose significant difficulties in discerning benign from potentially malignant conditions.
  • In this report we describe the pitfalls and radiological uncertainties with interpreting vascular lesions of the liver.
  • [MeSH-major] Granuloma, Pyogenic / diagnosis. Liver Diseases / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging

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  • (PMID = 19502177.001).
  • [ISSN] 1499-3872
  • [Journal-full-title] Hepatobiliary & pancreatic diseases international : HBPD INT
  • [ISO-abbreviation] HBPD INT
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 6
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63. Hansen T, Habekost M, Flieger D, Kirkpatrick CJ: [Littoral cell angioma of the spleen. Association with colon and hepatocellular carcinoma]. Pathologe; 2010 Jul;31(4):290-2
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  • [Title] [Littoral cell angioma of the spleen. Association with colon and hepatocellular carcinoma].
  • [Transliterated title] Littoralzellangiom der Milz. Assoziation mit Kolon- und hepatozellulärem Karzinom.
  • Littoral cell angioma is a rare vascular tumor of the spleen.
  • Due to the relationship with malignant tumors littoral cell angioma should be considered in every case of a splenic tumoral space-occupying mass, particularly in carcinoma patients.
  • [MeSH-major] Adenocarcinoma / pathology. Carcinoma, Hepatocellular / pathology. Colonic Neoplasms / pathology. Hemangioma / pathology. Liver Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Splenic Neoplasms / pathology
  • [MeSH-minor] Aged. Antigens, CD / analysis. Antigens, CD31 / analysis. Antigens, Differentiation, Myelomonocytic / analysis. Biomarkers, Tumor / analysis. Colectomy. Colon / pathology. Hepatectomy. Humans. Liver / pathology. Male. Neoplasm Staging. Spleen / pathology. Splenectomy

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  • (PMID = 20349061.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD31; 0 / Antigens, Differentiation, Myelomonocytic; 0 / Biomarkers, Tumor; 0 / CD68 antigen, human
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4. Wan P, Susman J, Kandel J, Jan D, Jerome EH, Parravicini E: Neonatal hepatic mesenchymal hamartoma causing cardiac failure and disseminated intravascular coagulopathy. Am J Perinatol; 2009 Sep;26(8):601-4
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  • [Title] Neonatal hepatic mesenchymal hamartoma causing cardiac failure and disseminated intravascular coagulopathy.
  • Even with advance prenatal diagnostic tools, differentiating among specific types of hepatic masses continues to challenge many physicians.
  • Here, we report a neonate with life-threatening hepatic mass, cardiac failure, and disseminated intravascular coagulopathy, which clinically resembled hepatic hemangioma.
  • A hepatic mesenchymal hamartoma was detected by postmortem pathology.
  • [MeSH-major] Disseminated Intravascular Coagulation / etiology. Hamartoma / complications. Hamartoma / congenital. Heart Failure / etiology. Liver Diseases / complications. Liver Diseases / congenital

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  • [Copyright] Thieme Medical Publishers.
  • (PMID = 19370509.001).
  • [ISSN] 1098-8785
  • [Journal-full-title] American journal of perinatology
  • [ISO-abbreviation] Am J Perinatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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66. Maizlin ZV, Vos PM, Cooperberg PL: Is it a fibroid? Are you sure? Sonography with MRI assistance. Ultrasound Q; 2007 Mar;23(1):55-62
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  • Uterine fibroids are common benign lesions.
  • Other common benign masses include renal cysts, renal angiomyolipomas, hepatic cysts, hepatic hemangiomas, thyroid cysts, adrenal incidentalomas, pulmonary granulomas and hamartomas, ovarian cysts, and dermoids.
  • [MeSH-minor] Diagnosis, Differential. Female. Humans

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  • (PMID = 17558230.001).
  • [ISSN] 0894-8771
  • [Journal-full-title] Ultrasound quarterly
  • [ISO-abbreviation] Ultrasound Q
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 28
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67. Noda T, Sasaki Y, Yamada T, Eguchi H, Takachi K, Noura S, Miyashiro I, Murata K, Doki Y, Ohigashi H, Ishikawa O, Imaoka S, Mitani H, Ishiguro S: Adult capillary hemangioma of the liver: report of a case. Surg Today; 2005;35(9):796-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adult capillary hemangioma of the liver: report of a case.
  • We report a rare case of capillary hemangioma of the liver in an adult.
  • The patient was a 55-year-old man, admitted for investigation of a hepatic tumor.
  • Computed tomography (CT) showed an enhancement pattern different from that of hepatocellular carcinoma (HCC) or cavernous hemangioma.
  • We could not establish whether the tumor was HCC or cavernous hemangioma by the imaging findings, so we performed a hepatic resection.
  • Histopathological examination confirmed a diagnosis of capillary hemangioma.
  • Ultrasonography, CT, and magnetic resonance imaging showed an intermediate pattern between cavernous hemangioma and HCC.
  • Thus, we must be aware of the possibility of capillary hemangioma when finding an atypical liver tumor inconsistent with HCC or cavernous hemangioma.
  • [MeSH-major] Hemangioma, Capillary / diagnosis. Hemangioma, Capillary / surgery. Liver Neoplasms / diagnosis. Liver Neoplasms / surgery
  • [MeSH-minor] Diagnosis, Differential. Diagnostic Imaging. Humans. Male. Middle Aged

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  • [Cites] Radiology. 1980 Oct;137(1 Pt 1):149-55 [7422836.001]
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  • (PMID = 16133680.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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68. Kadri Aribas B, Dingil G, Ungul U, Sahin G, Nil Unlu D, Dogan K, Simsek Z, Kaya G, Yilmaz K, Yucel E, Demir P: Accuracy and safety of percutaneous US-guided needle biopsies in liver metastasis and hemangiomas. Minerva Gastroenterol Dietol; 2010 Dec;56(4):377-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Accuracy and safety of percutaneous US-guided needle biopsies in liver metastasis and hemangiomas.
  • AIM: The aim of this study was to compare small size aspiration and large size cutting needles on the diagnostic yield in the biopsies of liver and especially to investigate the reliability on percutaneous biopsy of liver hemangiomas.
  • METHODS: Nine hundred fifty patients with percutaneous ultrasonography-guided liver biopsies were evaluated retrospectively.
  • Further evaluation was performed in 312 patients with metastasis and 48 patients with hemangiomas.
  • RESULTS: Diagnostic yield was higher in the large size cutting needle group (96.8%, 150/155) than in the small size aspiration needle group (84.1%, 132/157) in liver metastasis (P<0.001).
  • Accuracy rate was 77.9% (208/267) in benign and 89.5% (514/574) in malignant diseases.
  • CONCLUSION: The authors suggest the use of large size cutting needles, because they provide more accurate diagnosis, and should be used in liver metastasis instead of small aspiration needles, if there is no on-site pathologist at aspiration biopsies or a more specific diagnosis is required.
  • All the needles, including the large cutting type, were found safe in the biopsies of liver hemangiomas.
  • [MeSH-major] Biopsy, Fine-Needle / methods. Hemangioma / pathology. Liver Neoplasms / pathology. Ultrasonography, Interventional
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Predictive Value of Tests. Retrospective Studies. Sensitivity and Specificity

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  • (PMID = 21139536.001).
  • [ISSN] 1121-421X
  • [Journal-full-title] Minerva gastroenterologica e dietologica
  • [ISO-abbreviation] Minerva Gastroenterol Dietol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Italy
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69. Lin CH, Yu JC, Shih ML, Peng YJ, Hsieh CB: Littoral cell angioma of the spleen in a patient with hepatocellular carcinoma. J Formos Med Assoc; 2005 Apr;104(4):282-5
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  • [Title] Littoral cell angioma of the spleen in a patient with hepatocellular carcinoma.
  • Littoral cell angioma (LCA) is a rare primitive vascular tumor of the spleen which is benign and usually associated with visceral malignancy.
  • The diagnosis of LCA is based on histologic and immunohistologic analysis.
  • Dynamic computed tomography studies showed splenomegaly (20 cm in long axis) with a hypodense tumor in the upper pole and a contrast-enhanced hepatic mass in the right lobe of the liver.
  • Histopathology showed a moderately differentiated HCC of the liver and splenic angioma with dilated vascular channels lined by plump endothelial cells.

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  • (PMID = 15909068.001).
  • [ISSN] 0929-6646
  • [Journal-full-title] Journal of the Formosan Medical Association = Taiwan yi zhi
  • [ISO-abbreviation] J. Formos. Med. Assoc.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
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70. Yeh WC, Yang PM, Huang GT, Sheu JC, Chen DS: Long-term follow-up of hepatic hemangiomas by ultrasonography: with emphasis on the growth rate of the tumor. Hepatogastroenterology; 2007 Mar;54(74):475-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-term follow-up of hepatic hemangiomas by ultrasonography: with emphasis on the growth rate of the tumor.
  • BACKGROUND/AIMS: It is not rare to find hepatic hemangiomas in people in Taiwan where hepatitis B is endemic during ultrasonographic examinations for the screening of hepatocellular carcinoma, and we can therefore monitor these hemangiomas longitudinally since detected.
  • METHODOLOGY: Totally 180 hepatic hemangiomas in 130 adult patients were followed up for more than 5 years with at least twice ultrasound examinations in our hospital.
  • The diagnosis of hemangiomas was made by typical ultrasonographic findings as well as compatible findings in other imaging modalities.
  • The doubling time of tumor volume was calculated for the enlarging hepatic hemangiomas.
  • RESULTS: The diameters of the 180 hemangiomas ranged from <8 cm - >4 cm in 11 (6.1%), < or =4 cm - >2 cm in 55 (30.6%), and < or =2 cm in 114 (63.3%).
  • Among them, the diameter of 14 (7.7%) hemangiomas in 13 patients increased.
  • The tumor volume doubling time of these hemangiomas ranged from 17.3 to 178.1 months.
  • CONCLUSIONS: Although hepatic hemangiomas are benign, some of them indeed grow slowly.
  • The growth rates of these hemangiomas varied and were definitely slower as compared with those of malignant hepatic tumors.
  • [MeSH-major] Carcinoma, Hepatocellular / ultrasonography. Hemangioma / ultrasonography. Liver Neoplasms / ultrasonography. Neoplasms, Multiple Primary / ultrasonography

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  • (PMID = 17523302.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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71. Horii KA, Drolet BA, Baselga E, Frieden IJ, Metry DW, Morel KD, Newell BD, Nopper AJ, Garzon MC, Hemangioma Investigator Group: Risk of hepatic hemangiomas in infants with large hemangiomas. Arch Dermatol; 2010 Feb;146(2):201-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Risk of hepatic hemangiomas in infants with large hemangiomas.
  • [MeSH-major] Hemangioma / epidemiology. Hemangioma / pathology. Liver Neoplasms / epidemiology. Skin Neoplasms / pathology

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  • (PMID = 20157038.001).
  • [ISSN] 1538-3652
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Databank-accession-numbers] ClinicalTrials.gov/ NCT00374335
  • [Publication-type] Letter; Multicenter Study
  • [Publication-country] United States
  • [Investigator] Horii KA; Drolet BA; Baselga E; Frieden IJ; Metry DW; Morel KD; Newell BD; Nopper AJ; Garzon MC; Chamlin SL; Haggstrom AN; Lucky AW; Mancini AJ; Siegel D; Holland K; Powell J; McCuaig CM; Adams D
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72. Lanthaler M, Freund M, Nehoda H: Laparoscopic resection of a giant liver hemangioma. J Laparoendosc Adv Surg Tech A; 2005 Dec;15(6):624-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Laparoscopic resection of a giant liver hemangioma.
  • We present a case report of hepatic resection performed laparoscopically for a giant symptomatic hemangioma.
  • The patient was a 50-year-old woman who was diagnosed with a giant hemangioma 20 cm in diameter.
  • As in the case of our patient, laparoscopic resection of hepatic hemangiomas can be performed successfully, even when dealing with giant hemangiomas.
  • [MeSH-major] Hemangioma / surgery. Laparoscopy / methods. Liver Neoplasms / surgery

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  • (PMID = 16366871.001).
  • [ISSN] 1092-6429
  • [Journal-full-title] Journal of laparoendoscopic & advanced surgical techniques. Part A
  • [ISO-abbreviation] J Laparoendosc Adv Surg Tech A
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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73. Dong KR, Zheng S, Xiao X: Conservative management of neonatal hepatic hemangioma: a report from one institute. Pediatr Surg Int; 2009 Jun;25(6):493-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Conservative management of neonatal hepatic hemangioma: a report from one institute.
  • PURPOSE: To summarize the conservative treatment of neonatal hepatic hemangioma at one institute.
  • PATIENTS AND MATERIALS: Fifteen cases of neonatal hepatic hemangioma were managed in our hospital during the previous 5 years.
  • Initial symptoms, combination symptoms, diagnosis, and treatment were analyzed.
  • Combination symptoms were multiple skin hemangiomas, pneumonia, and cardiac insufficiency.
  • Ultrasound and CT showed the typical characteristics of the liver hemangioma.
  • There were three types of hepatic hemangioma: nine cases had a single focus, four cases were multiple foci, and two had diffuse changes in the liver.
  • One patient having multi-focus in the liver gave up the treatment after biopsy.
  • In those who received conservative therapy, all hemangiomas disappeared within 1 year.
  • CONCLUSION: The diagnosis of hepatic hemangioma can be made from symptomology, ultrasound, and CT; pathologic samples are not necessary.
  • Proactive therapy for congestive heart failure is helpful for those endangering liver hemangioma.
  • Surgery can increase the risk of complications and is not advised for treatment of neonatal hepatic hemangioma.
  • [MeSH-major] Hemangioma / diagnosis. Hemangioma / therapy. Liver Neoplasms / diagnosis. Liver Neoplasms / therapy

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  • (PMID = 19415303.001).
  • [ISSN] 1437-9813
  • [Journal-full-title] Pediatric surgery international
  • [ISO-abbreviation] Pediatr. Surg. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Glucocorticoids
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74. Losanoff JE, Millis JM: Liver hemangioma complicated by obstructive jaundice. Am J Surg; 2008 Sep;196(3):e3-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Liver hemangioma complicated by obstructive jaundice.
  • This report describes a liver hemangioma causing obstructive jaundice, an extremely rare condition that has been reported on 3 previous occasions.
  • A hemangioma can compress the major bile ducts and require partial hepatectomy for a successful outcome.
  • [MeSH-major] Hemangioma, Cavernous / complications. Jaundice, Obstructive / etiology. Liver Neoplasms / complications

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  • (PMID = 18519125.001).
  • [ISSN] 1879-1883
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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75. Ertan G, Tekes A, Mitchell S, Keefer J, Huisman TA: Pediatric littoral cell angioma of the spleen: multimodality imaging including diffusion-weighted imaging. Pediatr Radiol; 2009 Oct;39(10):1105-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pediatric littoral cell angioma of the spleen: multimodality imaging including diffusion-weighted imaging.
  • Littoral cell angioma (LCA) is a rare primary splenic vascular tumor originating from littoral cells lining the splenic red pulp sinuses.
  • Previous studies on liver lesions have shown that DWI allows differentiation of vascular tumors from primary neoplasms and metastatic disease.
  • The current case indicates that increased ADC values within the splenic lesions suggest a vascular etiology, which might help narrow the differential diagnosis.
  • [MeSH-major] Diffusion Magnetic Resonance Imaging / methods. Hemangioma / diagnosis. Splenic Neoplasms / diagnosis. Tomography, X-Ray Computed / methods. Ultrasonography / methods


76. Cho SH, Lee JY, Han JK, Choi BI: Acoustic radiation force impulse elastography for the evaluation of focal solid hepatic lesions: preliminary findings. Ultrasound Med Biol; 2010 Feb;36(2):202-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Acoustic radiation force impulse elastography for the evaluation of focal solid hepatic lesions: preliminary findings.
  • This study was designed to investigate the potential usefulness of acoustic radiation force impulse (ARFI) elastography to evaluate focal solid hepatic lesions.
  • In total, 51 patients with 60 focal hepatic lesions, which included 17 hemangiomas, 25 hepatocellular carcinomas (HCCs), 15 metastases and three cholangiocarcinomas, underwent ARFI elastography.
  • The lesions were classified into three groups: Group I consisted of metastatic liver tumors and cholangiocarcinomas, group II consisted of HCCs and group III consisted of hemangiomas.
  • Shear wave velocity was obtained to quantify stiffness for 36 focal hepatic lesions: 11 hemangiomas, 17 HCCs and eight other malignant lesions.
  • On ARFI elastography images, group I tumors (n=18) appeared stiffer than the background liver for 13 lesions (72%), softer for two lesions and had identical stiffness in three lesions compared with the background liver.
  • For group II tumors (n=25), 13 lesions (52%) appeared stiffer than the liver, six lesions appeared softer than the liver and the remaining six lesions showed the same stiffness as the liver.
  • For group III tumors (n=17), six lesions (35%) appeared stiffer than the liver, seven lesions appeared softer and the remaining four lesions showed the same stiffness as the liver.
  • Images obtained with ARFI elastography provided additional qualitative information regarding the stiffness and tumor margin of liver tumors.
  • By measuring shear wave velocity, quantification of stiffness was made possible and showed the potential to differentiate malignant hepatic tumors from hepatic hemangiomas.
  • [MeSH-major] Elasticity Imaging Techniques. Liver Neoplasms / ultrasonography

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  • [Copyright] 2010 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20018432.001).
  • [ISSN] 1879-291X
  • [Journal-full-title] Ultrasound in medicine & biology
  • [ISO-abbreviation] Ultrasound Med Biol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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77. Colakoğlu O, Taşkiran B, Yazici N, Buyraç Z, Unsal B: Safety of biopsy in liver hemangiomas. Turk J Gastroenterol; 2005 Dec;16(4):220-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Safety of biopsy in liver hemangiomas.
  • Hemangiomas are the most common tumors of the liver.
  • In case of inconclusive radiologic features and a history of malignancy or underlying liver disease, liver biopsy is indicated.
  • Bleeding is the most feared complication of biopsy of hemangiomas due to its highly vascular structure.
  • In our clinic, we biopsied seven patients with suspected masses and they were diagnosed histopathologically afterwards as having hemangiomas.
  • Although the case number is too small to reach a definite conclusion, we think that our report deserves attention in showing that concerns about bleeding during biopsy of hemangiomas may be overstated.
  • [MeSH-major] Hemangioma / pathology. Liver Neoplasms / pathology
  • [MeSH-minor] Biopsy, Needle / methods. Diagnosis, Differential. Humans. Middle Aged

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  • (PMID = 16547852.001).
  • [ISSN] 1300-4948
  • [Journal-full-title] The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
  • [ISO-abbreviation] Turk J Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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78. Zincirkeser S, Celen ZY, Yilmaz M, Topalhan F, Sahin E: A false negative by planar scintigraphy liver hemangioma, diagnosed by technetium-99m-red blood cells and technetium-99m-sulfur colloid single photon emission tomography scan. Hell J Nucl Med; 2006 May-Aug;9(2):109-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A false negative by planar scintigraphy liver hemangioma, diagnosed by technetium-99m-red blood cells and technetium-99m-sulfur colloid single photon emission tomography scan.
  • Ultrasonography showed a 4.7 cm solid hepatic mass on the right lateral side of the right lobe of the liver.
  • The patient was then sent to the Nuclear Medicine Department of Gaziantep University for liver scan.
  • After injecting autologous red blood cells labeled with 740 MBq of technetium-99m ((99m)Tc-RBC), early and delayed anterior planar images of the liver showed no significant findings because of the right kidney shine through the liver.
  • Two days later, after injecting again 740 MBq of (99m)Tc-RBC, we performed a single photon emission tomography (SPET) scan but still this scan was nondiagnostic even in the delayed images of the liver.
  • Three days later, after the iv injection of 185 MBq of technetium-99m-sulphur colloid ((99m)Tc-SC), we observed in the delayed SPET images of the liver, a mismatch defect with decreased focal uptake of (99m)Tc-SC at 60 min while the uptake of (99m)Tc-RBC at the same area was normal or slightly increased.
  • A cavernous hemangioma was found, confirmed by histology.
  • In conclusion, the mismatch of the SPET delayed images between the (99m)Tc-RBC and the (99m)Tc-SC scans indicated that this procedure was effective for the diagnosis of liver cavernous hemangioma located in this unusual position.
  • [MeSH-major] Erythrocytes / radionuclide imaging. Hemangioma / radionuclide imaging. Liver Neoplasms / radionuclide imaging. Technetium. Technetium Tc 99m Sulfur Colloid. Tomography, Emission-Computed, Single-Photon / methods

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  • [CommentIn] Hell J Nucl Med. 2009 May-Aug;12(2):177-8 [19675879.001]
  • [CommentIn] Hell J Nucl Med. 2006 Sep-Dec;9(3):187 [17160164.001]
  • (PMID = 16894416.001).
  • [ISSN] 1790-5427
  • [Journal-full-title] Hellenic journal of nuclear medicine
  • [ISO-abbreviation] Hell J Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 556Q0P6PB1 / Technetium Tc 99m Sulfur Colloid; 7440-26-8 / Technetium
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79. Bozgeyik Z, Kocakoc E, Gul Y, Dagli AF: Evaluation of liver hemangiomas using three different b values on diffusion MR. Eur J Radiol; 2010 Sep;75(3):360-3
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  • [Title] Evaluation of liver hemangiomas using three different b values on diffusion MR.
  • PURPOSE: To determine which diffusion-weighted MR technique (i.e., b-100, b-600, b-1000 s/mm(2)) is most useful in depicting liver hemangiomas.
  • MATERIALS AND METHODS: Diffusion-weighed MR (DWMR) was performed for 61 hemangiomas in 32 patients.
  • ADCs were measured for each lesions and compared with normal liver parenchymal ADCs on different b values.
  • Hemangiomas were subdivided according to lesion size (less than 3 cm and 3 cm or greater).
  • Lower ADC values were obtained for higher b values in normal liver tissue and hemangiomas.
  • Although there is significant difference between normal liver tissue and hemangiomas; this is more apparent on b-1000 images (p=0.022 on b-100, p=0.003 on b-600, and p=0.000 on b-1000 images).
  • Variance analysis revealed hemangiomas had higher ADC values than normal liver tissue on b-1000 images.
  • CONCLUSION: Mean values for ADCs of hemangiomas were lower than ADCs of the normal liver except for b-1000 value.
  • Higher b values are useful for the differentiation between normal liver tissue and hemangiomas.
  • [MeSH-major] Diffusion Magnetic Resonance Imaging / methods. Hemangioma / diagnosis. Image Enhancement / methods. Liver Neoplasms / diagnosis

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  • [Copyright] Copyright © 2009 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 19481893.001).
  • [ISSN] 1872-7727
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] Ireland
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80. Gourgiotis S, Moustafellos P, Zavos A, Dimopoulos N, Vericouki C, Hadjiyannakis EI: Surgical treatment of hepatic haemangiomas: a 15-year experience. ANZ J Surg; 2006 Sep;76(9):792-5
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  • [Title] Surgical treatment of hepatic haemangiomas: a 15-year experience.
  • BACKGROUND: Hepatic haemangiomas are congenital vascular malformations.
  • They are the most common benign tumours of the liver and are often asymptomatic.
  • We present our experience over the last 15 years with the surgical management of 15 liver haemangiomas to clarify the safety and effectiveness of this treatment.
  • METHODS: There were 15 patients with hepatic haemangiomas who were surgically treated from 1990 to 2004.
  • Indications for the operation were spontaneous or traumatic rupture, consumption coagulopathy, rapid growth, abdominal pain and uncertain diagnosis.
  • Methods for diagnosis included ultrasonography, computed tomography scan, magnetic resonance imaging and selective hepatic arteriography or combinations of more than one technique.
  • CONCLUSION: The resection of the hepatic haemangioma is safe.
  • [MeSH-major] Hemangioma / surgery. Liver Neoplasms / surgery

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  • (PMID = 16922900.001).
  • [ISSN] 1445-1433
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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81. R Aglyamov S, R Skovoroda A, Xie H, Kim K, M Rubin J, O'Donnell M, W Wakefield T, Myers D, Y Emelianov S: Model-based reconstructive elasticity imaging using ultrasound. Int J Biomed Imaging; 2007;2007:35830
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  • The model-based approach is illustrated using two potential clinical applications: differentiation of liver hemangioma and staging of deep venous thrombosis.

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  • [ISSN] 1687-4188
  • [Journal-full-title] International journal of biomedical imaging
  • [ISO-abbreviation] Int J Biomed Imaging
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / R01 HL068658
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1986825
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82. Lai HJ, Yu JC, Liu YC, Shih ML, Hsieh CB: Anterior approach for a symptomatic giant hepatic haemangioma (&gt;30 centimetre). ANZ J Surg; 2006 Sep;76(9):863-5
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  • [Title] Anterior approach for a symptomatic giant hepatic haemangioma (>30 centimetre).
  • [MeSH-major] Hemangioma / surgery. Hepatectomy / methods. Liver Neoplasms / surgery

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  • (PMID = 16922914.001).
  • [ISSN] 1445-1433
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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83. Yun JP, Miao J, Chen GG, Tian QH, Zhang CQ, Xiang J, Fu J, Lai PB: Increased expression of nucleophosmin/B23 in hepatocellular carcinoma and correlation with clinicopathological parameters. Br J Cancer; 2007 Feb 12;96(3):477-84
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  • In this study, we examined NPM expression in 103 paired cases of hepatocellular carcinoma (HCC), 12 cases of hepatic focal nodular hyperplasia, 17 cases of liver tissue adjacent to a hepatic haemangioma, and series of array tissues from normal human organs and malignancies using a monoclonal antibody against NPM and reverse transcription-PCR techniques, Western blot analysis, immunohistochemistry, and immunocytofluorescence.
  • Moreover, enhanced expression of NPM in HCC correlated with the level of PCNA (R(2)=0.5639) and with the clinical prognostic parameters such as serum alpha fetal protein level, tumour pathological grading, and liver cirrhosis (P<0.05).
  • [MeSH-major] Carcinoma, Hepatocellular / chemistry. Liver Neoplasms / chemistry. Nuclear Proteins / analysis

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  • (PMID = 17245342.001).
  • [ISSN] 0007-0920
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Nuclear Proteins; 0 / Proliferating Cell Nuclear Antigen; 117896-08-9 / nucleophosmin
  • [Other-IDs] NLM/ PMC2360035
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84. Inoue A, Okura Y, Kawashita I, Ito K, Matsunaga N, Sanada T, Akiyama M, Ishida T: [Development of comprehensive image processing technique for differential diagnosis of liver disease by using multi-modality images-pixel-based cross-correlation method using a profile-]. Nihon Hoshasen Gijutsu Gakkai Zasshi; 2009 Apr 20;65(4):438-50
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  • [Title] [Development of comprehensive image processing technique for differential diagnosis of liver disease by using multi-modality images-pixel-based cross-correlation method using a profile-].
  • In this scheme, the criteria of an attending radiologist for the differential diagnosis of liver cyst, hemangioma of liver, hepatocellular carcinoma, and metastatic liver cancer on magnetic resonance images with various sequences and CT images with and without contrast enhancement employ a cross-correlation coefficient.
  • This comprehensive image-processing technique could assist radiologists in the differential diagnosis of liver diseases.
  • [MeSH-major] Image Processing, Computer-Assisted / methods. Liver Diseases / diagnosis. Magnetic Resonance Imaging / methods. Tomography, Spiral Computed / methods
  • [MeSH-minor] Diagnosis, Differential. Humans

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  • (PMID = 19420828.001).
  • [ISSN] 0369-4305
  • [Journal-full-title] Nihon Hōshasen Gijutsu Gakkai zasshi
  • [ISO-abbreviation] Nihon Hoshasen Gijutsu Gakkai Zasshi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
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85. Su TH, Liu WL, Yu CJ, Huang GT: Unusual dyspnoea in a patient with liver cirrhosis. BMJ Case Rep; 2009;2009
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  • [Title] Unusual dyspnoea in a patient with liver cirrhosis.
  • A 66-year-old woman with hepatitis C related liver cirrhosis presented to our hospital for dyspnoea and cyanosis.
  • Tachypnoea, low grade fever, clubbed fingers, palmar erythaema, spider angioma, wheezing and severe hypoxaemia were found.
  • She was followed in our clinic for 3 years and her respiratory condition on home oxygen remained stable, as did the liver cirrhosis.

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  • (PMID = 21686887.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3027928
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86. Madhusudhan KS, Srivastava DN, Gamanagatti S: Giant hemangioma of liver presenting as deep vein thrombosis of the lower limbs. J Postgrad Med; 2009 Oct-Dec;55(4):290-1
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  • [Title] Giant hemangioma of liver presenting as deep vein thrombosis of the lower limbs.
  • [MeSH-major] Hemangioma / complications. Liver Neoplasms / complications. Venous Thrombosis / etiology


87. Marinis A, Kairi E, Theodosopoulos T, Kondi-Pafiti A, Smyrniotis V: Right colon and liver hemangiomatosis: a case report and a review of the literature. World J Gastroenterol; 2006 Oct 21;12(39):6405-7
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  • [Title] Right colon and liver hemangiomatosis: a case report and a review of the literature.
  • Cavernous hemangiomatosis of the colon and liver in a 38-year-old woman presenting with a history of cramp like abdominal pain and a mass in the right iliac fossa are presented.
  • Abdominal ultrasonography and computed tomography demonstrated multiple liver hemangiomas as well as a noncystic lesion in the right iliac fossa.
  • [MeSH-major] Colonic Neoplasms / diagnosis. Hemangioma, Cavernous / diagnosis. Liver Neoplasms / diagnosis

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  • (PMID = 17072971.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 16
  • [Other-IDs] NLM/ PMC4088156
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88. Fan RF, Chai FL, He GX, Wan WX, Bai MD, Cao ML, Li HM, Yan SZ: [Radiofrequency ablation therapy combined with suture and ligation surgery for patients with giant cavernous hemangiomas of the liver]. Zhonghua Yi Xue Za Zhi; 2006 Aug 15;86(30):2134-7
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  • [Title] [Radiofrequency ablation therapy combined with suture and ligation surgery for patients with giant cavernous hemangiomas of the liver].
  • OBJECTIVE: To evaluate the feasibility and efficacy of radiofrequency ablation (RFA) therapy combined with suture and ligation surgery for patients with giant hepatic cavernous hemangioma (HCH).
  • METHODS: Between June 2004 and June 2005, a total of 30 patients were treated by RFA therapy after suture and ligation surgery (SL group, n = 15, with 18 liver lesions) or RFA therapy without suture and ligation surgery (non-SL group, n = 15, with 17 liver lesions) under general anesthesia.
  • Preoperative diagnosis of HCH was established by means of ultrasonography, helical computed tomography (CT) scans, and magnetic resonance imaging (MRI).
  • All of the 35 lesions were located on the liver surface, in the caudate lobe of the liver, or adjacent to the gallbladder.
  • Cholecystectomy was performed simultaneously for gallstones in 7 patients and for abutting of gallbladder from hemangioma in 2 patients.
  • [MeSH-major] Catheter Ablation. Hemangioma, Cavernous / surgery. Liver Neoplasms / surgery

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  • (PMID = 17064621.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Randomized Controlled Trial
  • [Publication-country] China
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89. Feuerlein S, Pauls S, Juchems MS, Stuber T, Hoffmann MH, Brambs HJ, Ernst AS: Pitfalls in abdominal diffusion-weighted imaging: how predictive is restricted water diffusion for malignancy. AJR Am J Roentgenol; 2009 Oct;193(4):1070-6
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  • The aim of our retrospective study was to investigate the specificity of restricted diffusion in differentiation of benign from malignant abdominal disease.
  • The 12 benign lesions were liver hemangioma, liver adenoma, autoimmune pancreatitis, pancreatic teratoma, two abscesses, three cases of inflammatory bowel wall thickening due to Crohn's disease, Bartholin cyst, hemorrhagic ovarian cyst, and renal Rosai-Dorfman disease.
  • However, in interpretation of diffusion-weighted images, it should be kept in mind that a number of benign lesions, as many as 22% in our cohort, can exhibit restricted diffusion on images with high b values, thus mimicking malignant lesions.
  • [MeSH-major] Abdominal Neoplasms / diagnosis. Artifacts. Diffusion Magnetic Resonance Imaging / methods

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  • (PMID = 19770331.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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90. Cao J, Luo S, Liang L, Lai J, Chen S: Effects of parenteral nutrition with and without GH on the GH/IGF-1 axis after hepatectomy in hepatocellular carcinoma with liver cirrhosis. Front Med China; 2007 Jul;1(3):287-93
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  • [Title] Effects of parenteral nutrition with and without GH on the GH/IGF-1 axis after hepatectomy in hepatocellular carcinoma with liver cirrhosis.
  • Postoperative hepatic insulin-like growth factor-1 (IGF-1) production may be severely disturbed in patients with liver cirrhosis.
  • Liver function, serum GH, IGF-1 and IGFBP-3 were measured before the operation and at post-operative days (POD) 1 and 6.
  • Insulin-like growth factor-1 and IGFBP-3 mRNA in the liver tissue was detected by RT-PCR.
  • The liver Ki67 immunohistochemistry staining was studied.
  • At the same time, 12 patients with cholelithiasis or liver hemangioma who underwent operation served as normal control group.
  • On POD 6, serum prealbumin, GH, IGF-1, IGFBP-3, hepatic IGF-1 mRNA, IGFBP-3 mRNA and liver Ki67 LI were higher in the rhGH + PN group than in the PN group.

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  • (PMID = 24573868.001).
  • [ISSN] 1673-7342
  • [Journal-full-title] Frontiers of medicine in China
  • [ISO-abbreviation] Front Med China
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
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91. Raynaud JJ, Béchade D, Desrame J, Algayres JP: [Corticotherapy and giant hemangioma of the liver. Return to the normal values of cytokines]. Gastroenterol Clin Biol; 2006 Jun-Jul;30(6-7):907-9
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  • [Title] [Corticotherapy and giant hemangioma of the liver. Return to the normal values of cytokines].
  • [Transliterated title] Corticothérapie et hémangiome géant du foie. Effets bénéfiques sur les symptômes et normalisation des cytokines.
  • We report the case of a 36 year-old woman presenting with a giant liver hemangioma revealed by febrile hepatomegaly and weight loss.
  • Clinical and radiological follow-up, for respectively 36 and 24 months, did not show any relapse of symptoms or evolution of the hemangioma.
  • [MeSH-major] Anti-Inflammatory Agents / therapeutic use. Cytokines / blood. Glucocorticoids / therapeutic use. Hemangioma / drug therapy. Liver Neoplasms / drug therapy. Prednisone / therapeutic use
  • [MeSH-minor] Adult. Biopsy. Female. Humans. Interleukin-1 / blood. Interleukin-6 / blood. Liver / pathology. Magnetic Resonance Imaging. Time Factors. Tomography, X-Ray Computed. Treatment Outcome. Tumor Necrosis Factor-alpha / analysis

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  • (PMID = 16885878.001).
  • [ISSN] 0399-8320
  • [Journal-full-title] Gastroentérologie clinique et biologique
  • [ISO-abbreviation] Gastroenterol. Clin. Biol.
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 0 / Cytokines; 0 / Glucocorticoids; 0 / Interleukin-1; 0 / Interleukin-6; 0 / Tumor Necrosis Factor-alpha; VB0R961HZT / Prednisone
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92. Yilmaz-Cankaya B, Kantarci M, Durur-Karakaya A, Yalcin A: Giant hepatic hemangioma. Eurasian J Med; 2009 Apr;41(1):74
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  • [Title] Giant hepatic hemangioma.

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  • (PMID = 25610071.001).
  • [ISSN] 1308-8734
  • [Journal-full-title] The Eurasian journal of medicine
  • [ISO-abbreviation] Eurasian J Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Turkey
  • [Other-IDs] NLM/ PMC4261654
  • [Keywords] NOTNLM ; Giant / MDCT Imaging / hepatic hemangioma
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93. Isaacs H Jr: Fetal hydrops associated with tumors. Am J Perinatol; 2008 Jan;25(1):43-68
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  • Leukemia and extracardiac teratomas were next in frequency followed by hepatic tumors, neuroblastoma, placental, soft tissue, and renal tumors.
  • No fetus with the diagnosis of cardiac rhabdomyoma, neuroblastoma, brain tumor, rhabdoid tumor, or histiocytosis associated with hydrops survived.
  • Those patients with placental chorangioma, pericardial teratoma, and hepatic hemangioma had the best outcome.

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  • (PMID = 18075961.001).
  • [ISSN] 0735-1631
  • [Journal-full-title] American journal of perinatology
  • [ISO-abbreviation] Am J Perinatol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 144
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94. Hida T, Nishie A, Tajima T, Taketomi A, Aishima S, Honda H: Sclerosed hemangioma of the liver: possible diagnostic value of diffusion-weighted magnetic resonance imaging. Jpn J Radiol; 2010 Apr;28(3):235-8
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  • [Title] Sclerosed hemangioma of the liver: possible diagnostic value of diffusion-weighted magnetic resonance imaging.
  • We present a case of a sclerosed hemangioma (SH) of the liver that showed a high apparent diffusion coefficient (ADC) value.
  • The patient was undergoing preoperative evaluation for a metastatic breast cancer lesion when a liver mass with a diameter of 3 cm was found.
  • Liver metastasis and cholangiocellular carcinoma could not be excluded based on the imaging findings.
  • After surgery, a definite diagnosis of SH was obtained.
  • We discuss the diagnostic value of diffusion-weighted imaging for SH of the liver.
  • [MeSH-major] Diffusion Magnetic Resonance Imaging. Hemangioma / diagnosis. Liver Neoplasms / diagnosis
  • [MeSH-minor] Aged. Breast Neoplasms / diagnosis. Breast Neoplasms / pathology. Carcinoma, Ductal, Breast / diagnosis. Diagnosis, Differential. Female. Humans. Neoplasms, Multiple Primary / diagnosis

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  • (PMID = 20437137.001).
  • [ISSN] 1867-108X
  • [Journal-full-title] Japanese journal of radiology
  • [ISO-abbreviation] Jpn J Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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95. Zhou HB, Xu QR, Wang H, Zhou DX, Wang H, Wang Q, Zhou SS, Tu QQ, Sun ZQ, Ai L, Wu MC, Hu HP: [Risk factors of intrahepatic cholangiocarcinoma: a case-control study]. Zhonghua Gan Zang Bing Za Zhi; 2009 Dec;17(12):935-9
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  • RESULTS: Univariate analysis showed significant difference in HBsAg seropositivity, liver cirrhosis, hepatolithiasis, choledocholithiasis and schistosomiasis between ICC patients and healthy controls (P < 0.05).
  • Multivariate analysis confirmed that HBsAg seropositivity, liver cirrhosis, hepatolithiasis and hepatic schistosomiasis were associated with ICC, and their adjusted odds ratio (95% confidence interval) were 10.265 (6.676-15.783), 13.101 (5.265-32.604), 18.242 (3.580-92.958), 18.435 (1.930-176.082), 15.102 (4.607-49.499) and 11.820 (3.522-39.668), respectively.
  • The incidence of hepatic cyst, cholecystolithiasis, hepatic hemangioma, fatty liver, diabetes mellitus, smoking and drinking were not significantly different between ICC patients and controls.
  • CONCLUSIONS: The HBV infection, liver cirrhosis, hepatolithiasis and hepatic schistosomiasis may be the risk factors for ICC in China.
  • [MeSH-minor] Adult. Aged. Case-Control Studies. Female. Hepatitis B Surface Antigens / blood. Hepatitis B e Antigens / blood. Humans. Liver Cirrhosis / complications. Liver Cirrhosis / epidemiology. Liver Diseases / complications. Liver Diseases / epidemiology. Logistic Models. Male. Middle Aged. Odds Ratio. Risk Factors

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  • (PMID = 20038337.001).
  • [ISSN] 1007-3418
  • [Journal-full-title] Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology
  • [ISO-abbreviation] Zhonghua Gan Zang Bing Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Hepatitis B Surface Antigens; 0 / Hepatitis B e Antigens
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96. Markiewicz-Kijewska M, Kasprzyk W, Broniszczak D, Bacewicz L, Ostoja-Chyzynska A, Ismail H, Kosciesza A, Dembowska-Baginska B, Teisseyre J, Kluge P, Brzezinska-Rajszys G, Jankowska I, Kalicinski P: Hemodynamic failure as an indication to urgent liver transplantation in infants with giant hepatic hemangiomas or vascular malformations--report of four cases. Pediatr Transplant; 2009 Nov;13(7):906-12
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  • [Title] Hemodynamic failure as an indication to urgent liver transplantation in infants with giant hepatic hemangiomas or vascular malformations--report of four cases.
  • The aim of this study was to present acute hemodynamic failure as a rare indication for liver transplantation in neonates and infants with liver hemangiomatosis.
  • We report four patients aged one to six months with giant liver hemangiomas, with huge arterio-venous shunting within these malformations.
  • In three, many skin hemangiomas were found.
  • Two children underwent rescue hepatic artery surgical ligation, which did not prevent heart and then multiorgan failure including liver failure.
  • After unsuccessful conventional therapy, all infants were considered for urgent liver transplantation; in three cases, it was performed with a living-related donor, and in one case with a deceased donor.
  • Liver transplantation should be considered as a rescue treatment in children with hepatic vascular malformations leading to hemodynamic insufficiency when conventional therapy is unsuccessful and multiorgan failure develops.
  • [MeSH-major] Hemangioma / surgery. Liver Diseases / therapy. Liver Transplantation / methods. Vascular Malformations / surgery


97. Hyun W, Gamo M, Hirose Y: [Anesthetic management of a patient with Osler-Weber-Rendu disease undergoing mitral valvuloplasty]. Masui; 2008 Feb;57(2):223-5
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  • The patient was a 79-year-old woman admitted to our hospital with diagnosis of heart failure, mitral regurgitation, and chronic atrial fibrillation.
  • Preoperaitve examination revealed moderate mitral regurgitation with prolapsed anterior leaflet, pulmonary hypertension, high cardiac output (6.85 l min(-1)), and multiple hepatic angiomas.

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  • (PMID = 18277578.001).
  • [ISSN] 0021-4892
  • [Journal-full-title] Masui. The Japanese journal of anesthesiology
  • [ISO-abbreviation] Masui
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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98. Vossen JA, Buijs M, Liapi E, Eng J, Bluemke DA, Kamel IR: Receiver operating characteristic analysis of diffusion-weighted magnetic resonance imaging in differentiating hepatic hemangioma from other hypervascular liver lesions. J Comput Assist Tomogr; 2008 Sep-Oct;32(5):750-6
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  • [Title] Receiver operating characteristic analysis of diffusion-weighted magnetic resonance imaging in differentiating hepatic hemangioma from other hypervascular liver lesions.
  • PURPOSE: To evaluate the role of diffusion-weighted imaging in differentiating between hepatic hemangiomas, both typical and atypical, and other hypervascular liver lesions.
  • METHODS: Retrospective review of 182 hypervascular liver lesions in 117 patients was performed.
  • Receiver operating characteristic analysis was used to determine the accuracy of diffusion-weighted imaging in differentiating hemangiomas from other hypervascular liver lesions.
  • RESULTS: Lesions included typical and atypical hemangioma (n = 38), hepatocellular carcinoma (HCC; n = 58), focal nodular hyperplasia (FNH; n = 22), and neuroendocrine tumor metastasis (NET; n = 64) with a mean tumor size of 5.3 cm.
  • Mean ADC value for hemangioma, HCC, FNH, and NET was 2.29 x 10(-3), 1.55 x 10(-3), 1.65 x 10(-3), and 1.43 x 10(-3) mm2/s, respectively.
  • There was a statistically significant difference in the ADC value of hemangioma compared with that of FNH (P < 0.001), HCC (P < 0.001), and NET (P < 0.001), respectively.
  • CONCLUSIONS: Diffusion-weighted magnetic resonance imaging and ADC maps can provide rapid quantifiable information to differentiate typical and atypical hemangiomas from other hypervascular liver lesions.

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  • (PMID = 18830105.001).
  • [ISSN] 1532-3145
  • [Journal-full-title] Journal of computer assisted tomography
  • [ISO-abbreviation] J Comput Assist Tomogr
  • [Language] ENG
  • [Grant] United States / NIBIB NIH HHS / EB / EB006351-03; United States / NIBIB NIH HHS / EB / T32 EB006351; United States / NIBIB NIH HHS / EB / T32 EB006351-03
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS139195; NLM/ PMC2760589
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99. Sarialioglu F, Erbay A, Demir S: Response of infantile hepatic hemangioma to propranolol resistant to high-dose methylprednisolone and interferon-α therapy. Pediatr Blood Cancer; 2010 Dec 15;55(7):1433-4
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  • [Title] Response of infantile hepatic hemangioma to propranolol resistant to high-dose methylprednisolone and interferon-α therapy.
  • [MeSH-major] Drug Resistance, Neoplasm. Hemangioendothelioma / drug therapy. Interferon-alpha / administration & dosage. Liver Neoplasms / drug therapy. Methylprednisolone / administration & dosage. Propranolol / therapeutic use

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  • Hazardous Substances Data Bank. PROPRANOLOL HYDROCHLORIDE .
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  • (PMID = 20981697.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Interferon-alpha; 9Y8NXQ24VQ / Propranolol; X4W7ZR7023 / Methylprednisolone
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100. Luo SM, Tan WM, Deng WX, Zhuang SM, Luo JW: Expression of albumin, IGF-1, IGFBP-3 in tumor tissues and adjacent non-tumor tissues of hepatocellular carcinoma patients with cirrhosis. World J Gastroenterol; 2005 Jul 21;11(27):4272-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • ALB mRNA, IGF-1 mRNA, and IGFBP-3 mRNA in liver tissues (including tumor tissues and adjacent non-tumor tissues) were detected by reverse transcriptase-polymerase chain reaction (RT-PCR).
  • Liver Ki67 immunohistochemistry staining was studied.
  • At the same time, 12 patients with cholelithiasis or liver angioma who underwent operation were segregated as normal control.
  • RESULTS: In HCC patients with cirrhosis, hepatic ALB mRNA, IGF-1 mRNA, and IGFBP-3 mRNA of tumor tissues or adjacent non-tumor tissues were lower than the normal liver tissues, while in tumor tissues, hepatic ALB mRNA and IGFBP-3 mRNA were lower, hepatic IGF-1 mRNA was higher than in adjacent non-tumor tissues.
  • Liver Ki67 labeling index (Ki67 LI) in tumor tissues or adjacent non-tumor tissues were higher than that in the normal liver tissues, while in tumor tissues it was higher than that in adjacent non-tumor tissues.
  • CONCLUSION: Imbalance of IGF-1 and IGFBP-3 may play a role in hepatocarcinogenesis and tumor development of liver cirrhosis patients.
  • [MeSH-major] Albumins / genetics. Carcinoma, Hepatocellular / physiopathology. Insulin-Like Growth Factor Binding Protein 3 / genetics. Insulin-Like Growth Factor I / genetics. Liver Neoplasms / physiopathology
  • [MeSH-minor] Gene Expression Regulation, Neoplastic. Humans. Liver Cirrhosis / genetics. Liver Cirrhosis / physiopathology

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  • (PMID = 16015705.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Albumins; 0 / Insulin-Like Growth Factor Binding Protein 3; 67763-96-6 / Insulin-Like Growth Factor I
  • [Other-IDs] NLM/ PMC4615458
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