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1. Wallen KE, Hadar EJ, Perry V, Bouldin TW, Loehr J, Blatt J: Posterior fossa neoplasm and PHACES syndrome: a case report. J Pediatr Hematol Oncol; 2009 Mar;31(3):203-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A 4-year-old girl with PHACES syndrome (posterior fossa brain malformations, hemangiomas, arterial anomalies, cardiac anomalies/coarctation of the aorta, eye abnormalities, and sternal clefting/supraumbilical raphe) developed a cerebellar pilocytic astrocytoma 18 months after resolution of her neck, ear, and thoracic hemangiomas.
  • Because cutaneous hemangiomas may have involuted by the time a patient is diagnosed with a central nervous system neoplasm, it seems possible that in other such patients the association may have gone unrecognized.
  • [MeSH-major] Abnormalities, Multiple. Astrocytoma / etiology. Brain / abnormalities. Hemangioma / complications. Infratentorial Neoplasms / etiology

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  • (PMID = 19262249.001).
  • [ISSN] 1536-3678
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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2. Osio A, Fraitag S, Hadj-Rabia S, Bodemer C, de Prost Y, Hamel-Teillac D: Clinical spectrum of tufted angiomas in childhood: a report of 13 cases and a review of the literature. Arch Dermatol; 2010 Jul;146(7):758-63
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Tufted angioma (TA) is a rare benign vascular tumor that mostly appears during infancy or early childhood.
  • Histologic tufts of capillaries infiltrating the whole dermis in a "cannonball" distribution pattern associated with dilated lymphatic vessels are characteristic of the disease and confirm the diagnosis.
  • Presentation was a nascent or florid tumor, usually a dusky red to violaceous plaque, that was indurated, firm, and sometimes associated with hyperhidrosis or hypertrichosis.
  • [MeSH-major] Hemangioma / pathology. Skin / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Male. Retrospective Studies. Young Adult

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  • (PMID = 20644037.001).
  • [ISSN] 1538-3652
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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3. Piccirilli M, di Norcia V, Frati A, Salvati M: Glioblastoma in irradiated elderly patients: two case reports. Neurosurg Rev; 2005 Jul;28(3):226-8
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  • We report our experience with two elderly patients with histologically proven diagnosis of glioblastoma multiforme who were treated 25 and 18 years earlier for tinea capitis and scalp cutaneous hemangioma respectively in the same areas where the glioblastoma multiforme had grown.
  • [MeSH-minor] Dermatologic Surgical Procedures. Female. Humans. Infant. Infant, Newborn. Intracranial Pressure. Male. Skin / pathology. Skin Transplantation. Surgical Flaps

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  • (PMID = 15614578.001).
  • [ISSN] 0344-5607
  • [Journal-full-title] Neurosurgical review
  • [ISO-abbreviation] Neurosurg Rev
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 35
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4. Haddy N, Andriamboavonjy T, Paoletti C, Dondon MG, Mousannif A, Shamsaldin A, Doyon F, Labbé M, Robert C, Avril MF, Fragu P, Eschwege F, Chavaudra J, Schvartz C, Lefkopoulos D, Schlumberger M, Diallo I, de Vathaire F: Thyroid adenomas and carcinomas following radiotherapy for a hemangioma during infancy. Radiother Oncol; 2009 Nov;93(2):377-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Thyroid adenomas and carcinomas following radiotherapy for a hemangioma during infancy.
  • BACKGROUND AND PURPOSE: A cohort study was performed to investigate the carcinogenic effect of treating skin hemangioma with ionizing radiation during early childhood.
  • METHODS AND MATERIALS: Of a total of 8307 patients treated for a skin hemangioma between 1940 and 1973 at the Institut Gustave-Roussy, 4767 were included in an incidence study, among whom 3795 had received radiotherapy.
  • Thyroid tumor cases were obtained by sending out a questionnaire, and were verified in pathological reports.
  • CONCLUSION: This study confirms that radiation treatment performed in the past for hemangioma during infancy increased the risk of thyroid carcinoma and adenoma.
  • Patients treated with external radiotherapy or with Radium 226 applicators for hemangiomas have to be more specifically followed up because this is the subgroup in whom the highest doses were received by the thyroid gland (more than 90% of the radiation doses were higher than 100 mGy).
  • [MeSH-major] Hemangioma / radiotherapy. Neoplasms, Radiation-Induced / etiology. Neoplasms, Second Primary / etiology. Thyroid Neoplasms / etiology


5. Fujita H, Asahina A, Tamaki K: Extensive tufted angioma of the left arm in a 47-year-old woman. Clin Exp Dermatol; 2009 Oct;34(7):e216-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extensive tufted angioma of the left arm in a 47-year-old woman.
  • [MeSH-major] Arm. Hemangioma / diagnosis. Skin Neoplasms / diagnosis


6. Selim H, Selim A, Khachemoune A, Metwally SA: Use of sclerosing agent in the management of oral and perioral hemangiomas: review and case reports. Med Sci Monit; 2007 Sep;13(9):CS114-119
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Use of sclerosing agent in the management of oral and perioral hemangiomas: review and case reports.
  • BACKGROUND: Most cutaneous hemangiomas involute spontaneously.
  • CASE REPORTS: Three hemangioma cases were treated by repeated local injection of 5% ethanolamine oleate solution.
  • CONCLUSIONS: Use of 5% ethanolamine oleate as a sclerosing agent for repeated intralesional injection in the management of facial hemangiomas is a safe treatment with acceptable results.
  • [MeSH-major] Hemangioma / drug therapy. Hemangioma / pathology. Mouth Neoplasms / drug therapy. Mouth Neoplasms / pathology. Sclerosing Solutions / therapeutic use. Sclerotherapy
  • [MeSH-minor] Adolescent. Biomarkers, Tumor / metabolism. Female. Humans. Immunohistochemistry. Infant. Tomography Scanners, X-Ray Computed

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  • (PMID = 17767124.001).
  • [ISSN] 1234-1010
  • [Journal-full-title] Medical science monitor : international medical journal of experimental and clinical research
  • [ISO-abbreviation] Med. Sci. Monit.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Sclerosing Solutions
  • [Number-of-references] 32
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7. Duffy KJ, Runge-Samuelson C, Bayer ML, Friedland D, Sulman C, Chun R, Kerschner JE, Metry D, Adams D, Drolet BA: Association of hearing loss with PHACE syndrome. Arch Dermatol; 2010 Dec;146(12):1391-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: PHACE syndrome describes a spectrum of anomalies associated with large facial infantile hemangiomas and characterized by posterior fossa malformations, hemangiomas, arterial anomalies, coarctation of the aorta and cardiac defects, and eye abnormalities.
  • Four of the 6 patients had magnetic resonance imaging features of lesions consistent with intracranial hemangiomas involving auditory structures.
  • All 6 patients had facial hemangiomas in a nearly identical distribution ipsilateral to the ear with the hearing loss, with involvement of the proposed facial segments S1 and S3, the affected ear, the periauricular region, and the midoccipital area of the scalp.
  • Patients with PHACE syndrome who have cutaneous hemangiomas involving the ear should be evaluated for intracranial hemangiomas and monitored for hearing loss.
  • Early detection and therapy of intracranial hemangiomas may slow or stop tumor growth, resultant hearing loss, and structural damage.
  • [MeSH-minor] Acoustic Impedance Tests. Aortic Coarctation / complications. Aortic Coarctation / diagnosis. Diagnosis, Differential. Eye Abnormalities / complications. Eye Abnormalities / diagnosis. Female. Follow-Up Studies. Humans. Infant, Newborn. Magnetic Resonance Imaging. Neurocutaneous Syndromes / complications. Neurocutaneous Syndromes / diagnosis. Otoacoustic Emissions, Spontaneous. Syndrome

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  • (PMID = 20713775.001).
  • [ISSN] 1538-3652
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Grant] United States / NIDCD NIH HHS / DC / K23DC008837
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] PHACE association
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8. Onesti MG, Trignano E, Fino P, Scuderi N: Neuro-ocular cutaneous syndrome: a case report. G Ital Dermatol Venereol; 2009 Aug;144(4):487-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Neuro-ocular cutaneous syndrome: a case report.
  • Neuro-ocular cutaneous syndrome is a rare and little-known illness.
  • It affects the ocular apparatus, the nervous system and the skin.
  • The disease causes pathologies such as phacomatosis, which is a generic term used to describe small cutaneous neoformations, as well as other ectodermal organ malformations (ocular apparatus and central nervous system).
  • The symptoms of this disease are ocular, neurological and dermatological and can include: corneal opacity, papillary coloboma, optical atrophy, epibulbar dermoids, corectopia, palpebral coloboma, frontoparietal alopecia, epilepsy, psychomotor delay, pedunculated skin growths, a yellowing of the frontal area, milled papules, milled patches of skin, cutaneous spotting, familial angioma and hemiplegia.
  • The clinical case of a 15 year-old patient (who was diagnosed at 10 months old) affected by the neuro-ocular cutaneous syndrome will be discussed below.

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  • (PMID = 19755953.001).
  • [ISSN] 0392-0488
  • [Journal-full-title] Giornale italiano di dermatologia e venereologia : organo ufficiale, Società italiana di dermatologia e sifilografia
  • [ISO-abbreviation] G Ital Dermatol Venereol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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9. Sevinir B, Ozkan TB: Infantile hepatic hemangioendothelioma: clinical presentation and treatment. Turk J Gastroenterol; 2007 Sep;18(3):182-7
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  • BACKGROUND/AIMS: Hepatic hemangioendotheliomas are rare tumors in childhood.
  • RESULTS: The median age at diagnosis was 24 days (age range: 1 to 70 days) and the female/male ratio was 5/3.
  • Cutaneous hemangiomas were present in four cases.
  • Four cases had single hepatic tumors while the others had multiple.
  • The tumor size ranged from 2 cm to 10 cm in diameter.
  • Most of the multifocal hepatic tumors were associated with skin hemangiomas.
  • [MeSH-major] Hemangioendothelioma / diagnosis. Hemangioendothelioma / therapy. Liver Neoplasms / diagnosis. Liver Neoplasms / therapy
  • [MeSH-minor] Abdomen. Alanine Transaminase / metabolism. Aspartate Aminotransferases / metabolism. Dilatation, Pathologic / etiology. Female. Glucocorticoids / therapeutic use. Hemangioma / diagnosis. Hepatomegaly / etiology. Humans. Immunologic Factors / therapeutic use. Infant. Infant, Newborn. Interferon-alpha / therapeutic use. Male. Neoplasms, Multiple Primary. Prednisolone / therapeutic use. Respiratory Distress Syndrome, Newborn / etiology. Retrospective Studies. Skin Neoplasms / diagnosis. Turkey / epidemiology

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  • (PMID = 17891692.001).
  • [ISSN] 2148-5607
  • [Journal-full-title] The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
  • [ISO-abbreviation] Turk J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Turkey
  • [Chemical-registry-number] 0 / Glucocorticoids; 0 / Immunologic Factors; 0 / Interferon-alpha; 9PHQ9Y1OLM / Prednisolone; EC 2.6.1.1 / Aspartate Aminotransferases; EC 2.6.1.2 / Alanine Transaminase
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10. Musumeci ML, Schlecht K, Perrotta R, Schwartz RA, Micali G: Management of cutaneous hemangiomas in pediatric patients. Cutis; 2008 Apr;81(4):315-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Management of cutaneous hemangiomas in pediatric patients.
  • Cutaneous hemangiomas (CHs) are common benign vascular tumors of childhood.
  • [MeSH-major] Hemangioma / therapy. Skin Neoplasms / therapy

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  • (PMID = 18491478.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 89
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11. Kamath GH, Bhat RM, Kumar S: Tufted angioma. Int J Dermatol; 2005 Dec;44(12):1045-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tufted angioma.
  • [MeSH-major] Hemangioma / pathology. Skin Neoplasms / pathology


12. Leal J, Davies AP, Selmi TA, Neyret P: Knee Arthroplasty in Klippel-Trenaunay syndrome: a case presentation with 5 years follow-up. J Arthroplasty; 2008 Jun;23(4):623-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Klippel-Trenaunay syndrome (KTS) is a triad of cutaneous hemangiomas, varicose veins, and localized hypertrophy of soft tissue and bone.
  • We describe the management of a 33-year-old patient with a diagnosis of KTS and severe knee arthropathy.
  • Precise preoperative diagnosis and analysis of the vascular abnormalities must be undertaken and the case discussed with vascular surgical colleagues as part of the preoperative planning process.

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  • (PMID = 18514887.001).
  • [ISSN] 0883-5403
  • [Journal-full-title] The Journal of arthroplasty
  • [ISO-abbreviation] J Arthroplasty
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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13. Mauroo NF, Rourke NL, Chan WK: Cutaneous hemangioma in a giant panda (Ailuropoda melanoleuca). J Zoo Wildl Med; 2006 Mar;37(1):59-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cutaneous hemangioma in a giant panda (Ailuropoda melanoleuca).
  • An adult male giant panda (Ailuropoda melanoleuca) was presented with a cutaneous mass ventral to the eye.
  • Histopathologic examination determined that the mass was a benign cavernous hemangioma, the first reported case in a giant panda.
  • [MeSH-major] Hemangioma, Cavernous / veterinary. Skin Neoplasms / veterinary. Ursidae

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  • (PMID = 17312815.001).
  • [ISSN] 1042-7260
  • [Journal-full-title] Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians
  • [ISO-abbreviation] J. Zoo Wildl. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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14. Lee B, Chiu M, Soriano T, Craft N: Adult-onset tufted angioma: a case report and review of the literature. Cutis; 2006 Nov;78(5):341-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adult-onset tufted angioma: a case report and review of the literature.
  • Tufted angiomas (TAs) are benign vascular tumors, primarily occurring on the trunk and extremities of children younger than 5 years.
  • [MeSH-major] Hemangioma / pathology. Lip Neoplasms / pathology. Skin Neoplasms / pathology


15. Metry D, Heyer G, Hess C, Garzon M, Haggstrom A, Frommelt P, Adams D, Siegel D, Hall K, Powell J, Frieden I, Drolet B, PHACE Syndrome Research Conference: Consensus Statement on Diagnostic Criteria for PHACE Syndrome. Pediatrics; 2009 Nov;124(5):1447-56
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVES: A subgroup of patients with infantile hemangiomas have associated structural anomalies of the brain, cerebral vasculature, eyes, sternum, and/or aorta in the neurocutaneous disorder known as PHACE syndrome.
  • The diagnosis has been broadly inclusive by using a case definition of a facial hemangioma plus >or=1 extracutaneous features, leading to numerous reports of potential associated disease features, many of uncertain significance.
  • Definite PHACE requires the presence of a characteristic segmental hemangioma or hemangioma >5 cm on the face or scalp plus 1 major criterion or 2 minor criteria.
  • Possible PHACE requires the presence of a hemangioma >5 cm on the face or scalp plus 1 minor criterion.
  • The group recognized that it may be possible to have PHACE syndrome with a hemangioma affecting the neck, chest, or arm only or no cutaneous hemangioma at all.
  • In such cases, fulfillment of additional required criteria would also lead to a possible PHACE diagnosis.
  • [MeSH-major] Abnormalities, Multiple / diagnosis. Head and Neck Neoplasms / diagnosis. Hemangioma / diagnosis. Neurocutaneous Syndromes / diagnosis
  • [MeSH-minor] Aorta / abnormalities. Brain / abnormalities. Eye Abnormalities / diagnosis. Humans. Infant. Sternum / abnormalities. Syndrome


16. Happle R: Angioma serpiginosum is not caused by PORCN mutations. Eur J Hum Genet; 2009 Jul;17(7):881-2; author reply 882
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angioma serpiginosum is not caused by PORCN mutations.
  • [MeSH-major] Membrane Proteins / genetics. Mutation. Skin Diseases, Vascular / diagnosis. Skin Diseases, Vascular / genetics
  • [MeSH-minor] Diagnosis, Differential. Focal Dermal Hypoplasia / diagnosis. Focal Dermal Hypoplasia / genetics. Focal Dermal Hypoplasia / physiopathology. Humans. Skin / physiopathology

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  • (PMID = 19337307.001).
  • [ISSN] 1476-5438
  • [Journal-full-title] European journal of human genetics : EJHG
  • [ISO-abbreviation] Eur. J. Hum. Genet.
  • [Language] eng
  • [Publication-type] Letter; Comment
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Membrane Proteins; EC 2.3.1.- / PORCN protein, human
  • [Other-IDs] NLM/ PMC2986492
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17. Jalil S, Akhtar J, Ahmed S: Corticosteroids therapy in the management of infantile cutaneous hemangiomas. J Coll Physicians Surg Pak; 2006 Oct;16(10):662-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Corticosteroids therapy in the management of infantile cutaneous hemangiomas.
  • OBJECTIVE: To determine the effectiveness of systemic and intra-lesional corticosteroids, in the management of infantile cutaneous hemangiomas and to compare the results with untreated lesions.
  • PATIENTS AND METHODS: A total of 75 cases with cutaneous hemangiomas were included in the study.
  • CONCLUSION: Hemangiomas when left untreated behave in an unpredictable manner.
  • [MeSH-major] Glucocorticoids / administration & dosage. Hemangioma / drug therapy. Skin Neoplasms / drug therapy

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  • (PMID = 17007757.001).
  • [ISSN] 1022-386X
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] Pakistan
  • [Chemical-registry-number] 0 / Glucocorticoids; 1ZK20VI6TY / Triamcinolone
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18. Suurmeijer AJ: Papillary hemangiomas and glomeruloid hemangiomas are distinct clinicopathological entities. Int J Surg Pathol; 2010 Feb;18(1):48-54
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  • [Title] Papillary hemangiomas and glomeruloid hemangiomas are distinct clinicopathological entities.
  • The author reviews and compares the clinicopathological features of papillary hemangiomas and glomeruloid hemangiomas, 2 rare, cutaneous intravascular capillary-type vascular lesions with overlapping morphological details.
  • Thin basement membranes and glomeruloid architecture are typical of glomeruloid hemangiomas, whereas papillae with thick mantles of a basement membrane- like matrix enveloping pericytes are prominent in papillary hemangiomas.
  • Thus, collagen IV staining patterns provide further evidence that papillary and glomeruloid hemangiomas represent distinct histopathological entities.
  • This additional technique should allow pathologists to readily distinguish between the lesions and make a proper diagnosis.
  • What is important is that glomeruloid hemangiomas-often presenting in a spectrum of multiple cutaneous vascular lesions, including cherry hemangiomas-are a hallmark of POEMS (acronym for polyneuropathy, oganomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) syndrome and/or multicentric Castleman's disease, whereas papillary hemangiomas clinically present as innocent solitary cutaneous hemangiomas in otherwise healthy individuals.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Hemangioma, Capillary / pathology. POEMS Syndrome / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / metabolism. Child. Child, Preschool. Female. Humans. Immunoenzyme Techniques. Male. Middle Aged. Young Adult

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  • (PMID = 18805868.001).
  • [ISSN] 1940-2465
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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19. Ishikawa K, Hatano Y, Ichikawa H, Hashimoto H, Fujiwara S: The spontaneous regression of tufted angioma. A case of regression after two recurrences and a review of 27 cases reported in the literature. Dermatology; 2005;210(4):346-8
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  • [Title] The spontaneous regression of tufted angioma. A case of regression after two recurrences and a review of 27 cases reported in the literature.
  • BACKGROUND: Tufted angioma, a peculiar angioma that is characterized by tufts of capillary-sized vessels scattered 'cannonball fashion' within the dermis, is known, on occasion, to regress spontaneously.
  • OBJECTIVE: To know the appropriate waiting period for spontaneous regression of tufted angioma.
  • METHODS: We report here a case of tufted angioma that regressed spontaneously after the lesions had recurred twice.
  • We also review previously reported cases of tufted angioma with spontaneous regression, including cases in the Japanese and non-Japanese literature.
  • [MeSH-major] Hemangioma, Capillary / pathology. Neoplasm Regression, Spontaneous / pathology. Skin Neoplasms / pathology

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  • [Copyright] 2005 S. Karger AG, Basel
  • (PMID = 15942226.001).
  • [ISSN] 1018-8665
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 10
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20. Wickless SC, McNulty M, Lichon VC: Focally pigmented pink plaque on the back. Concomitant melanoma in situ, basal cell carcinoma (BCC), and angioma. Arch Dermatol; 2010 Jul;146(7):789-94
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  • [Title] Focally pigmented pink plaque on the back. Concomitant melanoma in situ, basal cell carcinoma (BCC), and angioma.
  • [MeSH-major] Carcinoma, Basal Cell / diagnosis. Hemangioma / diagnosis. Melanoma / diagnosis. Neoplasms, Multiple Primary / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged, 80 and over. Biopsy. Diagnosis, Differential. Humans. Male


21. Sivaprakasam MJ, Dolak JA: Anesthetic and obstetric considerations in a parturient with Klippel-Trenaunay syndrome. Can J Anaesth; 2006 May;53(5):487-91
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  • Klippel-Trenaunay syndrome is a congenital vascular disease characterized by cutaneous hemangiomas, venous varicosities, and limb hypertrophy; and is associated with both hemorrhagic and thrombotic complications.
  • The importance of this diagnosis, including the presence of neuraxial vascular anomalies, is often under-appreciated by both obstetric and anesthesia providers.
  • CONCLUSIONS: The posterior cutaneous hemangiomas of KTS may be associated with underlying epidural and subdural vascular malformations.
  • Disruption of these vascular anomalies during regional anesthesia may lead to neuraxial hematoma formation, which may be further compounded by a consumptive coagulopathy observed in some cases of KTS.
  • If neuraxial vascular anomalies cannot be ruled out radiographically, regional anesthesia should be avoided.

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  • (PMID = 16636034.001).
  • [ISSN] 0832-610X
  • [Journal-full-title] Canadian journal of anaesthesia = Journal canadien d'anesthésie
  • [ISO-abbreviation] Can J Anaesth
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
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22. Kalisiak MS, Haber RM: Angioma serpiginosum with linear distribution: case report and review of the literature. J Cutan Med Surg; 2008 Jul-Aug;12(4):180-3
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  • [Title] Angioma serpiginosum with linear distribution: case report and review of the literature.
  • BACKGROUND: Angioma serpiginosum is a vascular anomaly that classically presents in childhood and predominantly affects females.
  • OBJECTIVE: To present a case of a young woman with linear distribution of angioma serpiginosum and review the common clinical characteristics and presentation of this condition.
  • METHODS: Case report with skin biopsies and dermoscopic findings.
  • The histopathologic findings of dilated blood vessels in the papillary dermis with absence of other changes confirmed the diagnosis of angioma serpiginosum.
  • CONCLUSION: Angioma serpiginosum is a rare entity that can be distinguished by clinical and histopathologic examinations.
  • [MeSH-major] Hemangioma / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adult. Arm. Biopsy. Diagnosis, Differential. Female. Humans


23. Oza VS, Wang E, Berenstein A, Waner M, Lefton D, Wells J, Blei F: PHACES association: a neuroradiologic review of 17 patients. AJNR Am J Neuroradiol; 2008 Apr;29(4):807-13
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  • BACKGROUND AND PURPOSE: We present neuroradiologic findings in 17 patients with posterior fossa malformations, hemangiomas, arterial anomalies, cardiac defects, eye abnormalities, and sternal or ventral defects (PHACES) association and identify those at highest risk of central nervous system (CNS) structural, cerebrovascular, and neurodevelopmental abnormalities.
  • MATERIALS AND METHODS: Patients with PHACES association were identified in the Vascular Anomalies Program at New York University Medical Center from 1998 to 2007.
  • Criteria for diagnosis of PHACES were based on previously published indicators.
  • Segmental mapping of cutaneous hemangioma distribution by photograph review and presence or absence of other PHACES-associated findings were correlated with radiologic findings.
  • RESULTS: Patients with large facial cutaneous (S1-S4) hemangiomas were especially at risk of CNS structural and cerebrovascular anomalies; S1 with ocular anomalies; and S3 with airway, ventral, and cardiac anomalies.
  • CONCLUSION: Our data support and expand the work of others, identifying risk factors for segmental hemangiomas.
  • [MeSH-major] Abnormalities, Multiple / diagnosis
  • [MeSH-minor] Child. Child, Preschool. Cranial Fossa, Posterior / abnormalities. Facial Neoplasms / diagnosis. Female. Hemangioma / diagnosis. Humans. Infant. Intracranial Arteriovenous Malformations / diagnosis. Male. Nervous System Malformations / diagnosis. Skin Neoplasms / diagnosis. Syndrome

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  • [CommentIn] AJNR Am J Neuroradiol. 2008 Apr;29(4):814-5 [18202231.001]
  • (PMID = 18223093.001).
  • [ISSN] 1936-959X
  • [Journal-full-title] AJNR. American journal of neuroradiology
  • [ISO-abbreviation] AJNR Am J Neuroradiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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24. Houge G, Oeffner F, Grzeschik KH: An Xp11.23 deletion containing PORCN may also cause angioma serpiginosum, a cosmetic skin disease associated with extreme skewing of X-inactivation. Eur J Hum Genet; 2008 Sep;16(9):1027-8
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  • [Title] An Xp11.23 deletion containing PORCN may also cause angioma serpiginosum, a cosmetic skin disease associated with extreme skewing of X-inactivation.
  • [MeSH-major] Chromosome Deletion. Chromosomes, Human, X / genetics. Focal Dermal Hypoplasia / genetics. Hemangioma / genetics. Membrane Proteins / genetics. Skin Neoplasms / genetics. X Chromosome Inactivation / genetics

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  • [CommentOn] Eur J Hum Genet. 2007 May;15(5):543-7 [17342156.001]
  • (PMID = 18478042.001).
  • [ISSN] 1018-4813
  • [Journal-full-title] European journal of human genetics : EJHG
  • [ISO-abbreviation] Eur. J. Hum. Genet.
  • [Language] eng
  • [Publication-type] Letter; Comment
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Membrane Proteins; EC 2.3.1.- / PORCN protein, human
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25. Al-Za'abi AM, Ghazarian D, Greenberg GR, Shaw JC: Eruptive tufted angiomas in a patient with Crohn's disease. J Clin Pathol; 2005 Feb;58(2):214-6
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  • Angioblastoma is a rare, benign vascular tumour composed of undifferentiated mesenchymal cells with a tendency to form lumina.
  • This entity was first described by Nakagawa in 1949 as angioblastoma, and Wilson Jones was the first to use the term "tufted angioma" in 1976.
  • He developed numerous small itchy erythematous vascular appearing papules, which on histological examination resembled tufted angiomas, showing the classic "cannon ball" appearance.
  • This case may represent an eruptive acquired tufted angioma in which immunosuppression or drug induced modification of angiogenesis played a role in its development and regression.
  • One previous case of eruptive tufted angioma has been reported in an immunosuppressed patient.
  • [MeSH-major] Crohn Disease / pathology. Hemangioma / pathology. Skin Neoplasms / pathology

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  • [Cites] Dermatology. 2000;201(1):68-70 [10971067.001]
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  • (PMID = 15677546.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Gastrointestinal Agents; B72HH48FLU / Infliximab
  • [Other-IDs] NLM/ PMC1770572
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26. Pascual-Castroviejo I, Pascual-Pascual SI, Velázquez-Fragua R, García L, López-Gutiérrez JC, Viaño-López J, Martínez V, Palencia R: [Cutaneous hemangiomas and vascular malformations and associated pathology (Pascual-Castroviejo type II syndrome). Study of 41 patients]. Rev Neurol; 2005 Aug 16-31;41(4):223-36
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  • [Title] [Cutaneous hemangiomas and vascular malformations and associated pathology (Pascual-Castroviejo type II syndrome). Study of 41 patients].
  • [Transliterated title] Hemangiomas y malformaciones vasculares cutáneas y patología asociada (síndrome de Pascual-Castroviejo tipo II). Presentación de 41 pacientes.
  • AIM: To describe the clinical, diagnostic and therapeutic features of this angiomatous neurocutaneous syndrome, which is the most frequent one, and to report a personal series of 41 patients.
  • The cutaneous lesions were classified as hemangiomas in 30 patients (73%) and as vascular malformations in 11 patients (27%).
  • The most frequent abnormalities were intracranial and/or extracranial vascular malformations.
  • Also were observed 4 patients (10%) with intracranial hemangioma, 2 (5%) with hemangioma in mediastinum, and 3 (7.5%) with intestinal hemangioma, all of which disappeared during the first years of life.
  • At the same time the cutaneous hemangioma regressed.
  • CONCLUSION: This neurocutaneous syndrome is the most frequent one and it is associated with several types of vascular and non-vascular abnormalities which can involve any organ of the body.
  • Internal and external hemangiomas and hemangiomatous lesions progress and tend to regress concomitantly.
  • [MeSH-major] Cardiovascular Abnormalities / pathology. Hemangioma / pathology. Neurocutaneous Syndromes / pathology. Skin Diseases, Vascular / pathology. Skin Neoplasms / pathology


27. Lee CW, Choi DY, Oh YG, Yoon HS, Kim JD: An infantile case of Sturge-Weber syndrome in association with Klippel-Trenaunay-Weber syndrome and phakomatosis pigmentovascularis. J Korean Med Sci; 2005 Dec;20(6):1082-4
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  • Klippel-Trenaunay-Weber syndrome is a rare congenital mesodermal phakomatosis characterized by cutaneous hemangiomas, venous varicosities and soft tissue or bone hypertrophy of the affected extremities.
  • He showed nevus flameus on the right leg and both part of the face and back, leptomeningeal angiomatosis on right hemisphere, hypertrophy of the right leg, hemiconvulsion on the left and also evidences of congenital glaucoma and nevus of Ota.

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  • (PMID = 16361829.001).
  • [ISSN] 1011-8934
  • [Journal-full-title] Journal of Korean medical science
  • [ISO-abbreviation] J. Korean Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2779316
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28. Lowman E, Mooradian AD: Macromelia masquerading as an acromegaloid syndrome in an adult with Klippel-Trénaunay syndrome. Endocr Pract; 2008 Jan-Feb;14(1):109-11
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  • The patient's insulinlike growth factor 1 concentration was 92 ng/mL (reference range, 117-329 ng/mL), which did not support the diagnosis of acromegaly.
  • Classically, the syndrome presents as a triad of vascular malformations, cutaneous hemangiomas, and bone or soft-tissue hypertrophy usually affecting one extremity.
  • [MeSH-major] Acromegaly / diagnosis. Klippel-Trenaunay-Weber Syndrome / diagnosis. Lymphedema / diagnosis. Port-Wine Stain / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male. Syndrome

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  • (PMID = 18238750.001).
  • [ISSN] 1934-2403
  • [Journal-full-title] Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
  • [ISO-abbreviation] Endocr Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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29. Rajesh, Bist SS, Saxena RK: Deviated nasal septum in case of Klippel-Trenaunay-Weber Syndrome. Indian J Otolaryngol Head Neck Surg; 2006 Jul;58(3):298-9
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  • It includes cutaneous hemangioma (Port-wine stains) of the face and extremities with associated varicosities and hypertrophy of underlying soft tissue and bone.
  • These patients can have involvement of oral cavity and nasal mucosa with angiomatous malformation, which can give rise to epistaxis and excessive bleeding during oral and nasal surgeries.

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  • [Cites] Acta Chir Scand. 1978;144(7-8):475-9 [218412.001]
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  • (PMID = 23120322.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3450391
  • [Keywords] NOTNLM ; Klippel-Trenaunay-Weber Syndrome / cutaneous hemangioma / deviated nasal septum / varicose vein
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30. Schupp CJ, Holland-Cunz S, Schenk JP, Weisser H, Grimm D, Günther P: Multiple hemangiomas and hemangiomatosis--risk factors and outcome over an eight year period. Eur J Pediatr Surg; 2010 Nov;20(6):379-81
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  • [Title] Multiple hemangiomas and hemangiomatosis--risk factors and outcome over an eight year period.
  • INTRODUCTION: Hemangiomas are the most common tumors of infancy.
  • Multiple cutaneous hemangiomas may be associated with the presence of hemangiomas in inner organs.
  • PATIENTS AND METHODS: patients with 3 or more cutaneous hemangiomas were evaluated with regard to patient characteristics, distribution of hemangiomas, results of radiological abdominal/cerebral imaging, clinical course, and therapeutic approach.
  • RESULTS: The average gestational week at birth was 32.8; radiological imaging showed liver hemangiomas in 13.5% and mesenteric lesions in 1 (1.9%) but no cerebral lesions.
  • Preterm infants (p=0.02) and patients with high numbers of cutaneous hemangiomas (p=0.02) were at higher risk of organ involvement.
  • CONCLUSIONS: Organ manifestation is relatively common in patients with multiple hemangiomas, complications are rare, but potentially life-threatening.
  • We recommend abdominal imaging for patients with 3 or more hemangiomas, especially in preterm infants.
  • [MeSH-major] Hemangioma / diagnosis

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  • [Copyright] © Georg Thieme Verlag KG Stuttgart · New York.
  • (PMID = 20665431.001).
  • [ISSN] 1439-359X
  • [Journal-full-title] European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift für Kinderchirurgie
  • [ISO-abbreviation] Eur J Pediatr Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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31. Pascual-Castroviejo I, Pascual-Pascual SI, Delgado J: Cutaneous hemangiomas and vascular abnormalities: persistence of embryonic vascularization. AJNR Am J Neuroradiol; 2007 Feb;28(2):390-1
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  • [Title] Cutaneous hemangiomas and vascular abnormalities: persistence of embryonic vascularization.
  • A 2-year-old girl presented with cutaneous facial, palpebral, back, perianal, and perineal hemangiomas and a subcutaneous neck and parotid voluminous hemangioma, associated with several extracranial vascular abnormalities, such as the absence of the ipsilateral internal carotid artery and hypoplasia of the common carotid arteries.
  • [MeSH-major] Cerebral Arteries / abnormalities. Hemangioma / radiography. Skin Diseases, Vascular / radiography. Vascular Neoplasms / radiography
  • [MeSH-minor] Carotid Artery, Common / abnormalities. Carotid Artery, Common / radiography. Carotid Artery, Internal / abnormalities. Carotid Artery, Internal / radiography. Child, Preschool. Face / blood supply. Female. Humans. Magnetic Resonance Angiography. Neck / blood supply. Skin / blood supply. Vertebral Artery / abnormalities. Vertebral Artery / radiography

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  • (PMID = 17297020.001).
  • [ISSN] 0195-6108
  • [Journal-full-title] AJNR. American journal of neuroradiology
  • [ISO-abbreviation] AJNR Am J Neuroradiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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32. Lange D, Oeder C, Waltermann K, Mueller A, Oehme A, Rohrberg R, Marsch W, Fischer M: Bacillary angiomatosis. J Dtsch Dermatol Ges; 2009 Sep;7(9):767-69
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  • A 79-year-old man presented with livid-erythematous, angioma-like skin lesions.
  • We considered a cutaneous infiltrate from his known chronic lymphocytic leukemia, Merkel cell carcinoma, cutaneous metastases of internal tumors, cutaneous sarcoidosis, mycobacterial infection and even atypical herpes simplex infection.
  • The correct diagnosis was proven histologically and by PCR.
  • [MeSH-major] Angiomatosis, Bacillary / diagnosis. Angiomatosis, Bacillary / microbiology. Bartonella henselae / isolation & purification. Cat-Scratch Disease / diagnosis. Cat-Scratch Disease / microbiology
  • [MeSH-minor] Aged. Diagnosis, Differential. Herpes Simplex / diagnosis. Humans. Male. Skin Neoplasms / diagnosis


33. Berbel Tornero O, Ferrís i Tortajada J, Donat Colomer J, Ortega García JA, Muñoz Guillén A, Verdeguer Miralles A: [Neonatal tumors: clinical and therapeutic characteristics. Analysis of 72 patients in La Fe University Children's Hospital in Valencia (Spain)]. An Pediatr (Barc); 2006 Aug;65(2):108-17
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  • [Title] [Neonatal tumors: clinical and therapeutic characteristics. Analysis of 72 patients in La Fe University Children's Hospital in Valencia (Spain)].
  • [Transliterated title] Tumores neonatales: características clínicas y terapéuticas. Análisis de 72 casos del hospital infantil La Fe de Valencia.
  • BACKGROUND: Neonatal tumors, which represent only 1.5-2% of all pediatric tumors, have distinctive features.
  • OBJECTIVE: To analyze and disseminate findings on the histological, clinical, therapeutic and follow-up characteristics of neonatal tumors.
  • MATERIAL AND METHODS: We performed a retrospective study of the clinical records of patients diagnosed with neonatal tumors in La Fe University Children's Hospital in Valencia (Spain) between January 1990 and December 1999.
  • Hamartomas, flat and cavernous cutaneous hemangiomas, nevi, lipomas, subcutaneous fibroma, lymphangiomas, and epidermal cysts were excluded.
  • The search profile combined neonatal or congenital and tumor or cancer or neoplasm.
  • RESULTS: The clinical records of 72 patients with neonatal tumors (40 boys and 32 girls), representing 2.8% of all pediatric tumors, were reviewed.
  • The most frequent tumors were hemangiomas (20.8%, 15 patients), neuroblastomas (16.7%, 12 patients), teratomas (12.5 %, 9 patients), and soft tissue tumors (9.7 %, 7 patients).
  • Although diagnosis was prenatal in 22.2 % of the patients, the most frequent findings on physical examination were identification of a mass or cutaneous lesion in 24 patients (33.3%) and an abdominal mass or hepatomegaly in 13 patients (18%).
  • Mortality was highest in patients with central nervous system tumors or leukemias (83.3% and 75 % respectively).
  • By contrast, none of the patients with hemangiomas or teratomas died.
  • CONCLUSIONS: Due to their biological features, neonatal tumors represent a distinctive subgroup in pediatric oncohematology.
  • The concept of neonatal tumor should be unified to allow the results of different research groups to be analyzed and compared.

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  • (PMID = 16948973.001).
  • [ISSN] 1695-4033
  • [Journal-full-title] Anales de pediatría (Barcelona, Spain : 2003)
  • [ISO-abbreviation] An Pediatr (Barc)
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 69
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34. Ilknur T, Fetil E, Akarsu S, Altiner DD, Ulukuş C, Güneş AT: Angioma serpiginosum: dermoscopy for diagnosis, pulsed dye laser for treatment. J Dermatol; 2006 Apr;33(4):252-5
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  • [Title] Angioma serpiginosum: dermoscopy for diagnosis, pulsed dye laser for treatment.
  • Angioma serpiginosum is a rare benign vascular disorder, characterized clinically by multiple minute, red to purple, grouped macules in serpiginous and gyrate patterns and histopathologically by ectatic dilatation of capillaries.
  • An 18-year-old man with angioma serpiginosum of his left arm was evaluated by dermoscopy and treated with pulsed dye laser.
  • Our case supports the hypothesis that dermoscopy is beneficial in the diagnosis of angioma serpiginosum and that pulsed dye laser is effective in the treatment of this disorder.
  • [MeSH-major] Hemangioma / pathology. Hemangioma / radiotherapy. Skin Neoplasms / pathology. Skin Neoplasms / radiotherapy

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  • (PMID = 16674788.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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35. Miyazaki H, Kato J, Watanabe H, Harada H, Kakizaki H, Tetsumura A, Sato A, Omura K: Intralesional laser treatment of voluminous vascular lesions in the oral cavity. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2009 Feb;107(2):164-72
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  • [Title] Intralesional laser treatment of voluminous vascular lesions in the oral cavity.
  • OBJECTIVE: In laser treatment of voluminous vascular lesions, there are many cases in which submucosally located angioma remnants cannot be reached by noncontact superficial laser application.
  • To diminish these remnants we used intralesional photocoagulation (ILP) in treatment of oral vascular lesions, because this approach is effective in treatment of voluminous vascular lesions of the skin.
  • STUDY DESIGN: Four cases of voluminous vascular malformation in the oral cavity were treated by ILP using a potassium-titanyl-phosphate (KTP) laser.
  • CONCLUSION: Intralesional photocoagulation treatment with a KTP laser is effective and safe for treatment of a vascular lesion in the oral cavity.
  • [MeSH-major] Hemangioma / surgery. Laser Coagulation / instrumentation. Lasers, Solid-State / therapeutic use. Mouth Neoplasms / surgery

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  • (PMID = 18930663.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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36. McAleer MA, Kirby B, Sheahan K, Collins P: An erythematous patch and plaque on the shoulder--quiz case. Acquired tufted angioma (TA). Arch Dermatol; 2008 Sep;144(9):1217-22
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  • [Title] An erythematous patch and plaque on the shoulder--quiz case. Acquired tufted angioma (TA).
  • [MeSH-major] Hemangioma / pathology. Shoulder. Skin Neoplasms / pathology


37. Tokuyama W, Mikami T, Masuzawa M, Okayasu I: Autocrine and paracrine roles of VEGF/VEGFR-2 and VEGF-C/VEGFR-3 signaling in angiosarcomas of the scalp and face. Hum Pathol; 2010 Mar;41(3):407-14
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  • Angiosarcoma of the skin is an extremely rare malignant tumor of vascular origin that usually arises in the scalp and face of elderly persons.
  • To clarify its characteristic features and cell cycle kinetics, we quantitatively evaluated the expression of cell cycle-related molecules and vascular endothelial growth factors using immunohistochemical staining, for comparison with 2 benign vascular tumors of the skin, the capillary hemangioma and the cavernous hemangioma.
  • Cell proliferation, determined with reference to the Ki-67 labeling index, was highest in angiosarcomas and lowest in cavernous hemangiomas (angiosarcomas versus capillary hemangioma, P = .014; capillary hemangioma versus cavernous hemangiomas, P = 1.4 x 10(-4)).
  • Expressions of cyclin D1 and p16(INK4A) were also significantly higher in angiosarcoma than in cavernous hemangioma.
  • Expression levels of vascular endothelial growth factor and its receptor, VEGFR-2, were highest in angiosarcomas.
  • VEGF-C expression in angiosarcomas was significantly higher than in cavernous hemangiomas, and its receptor VEGFR-3 expression was highest in angiosarcomas.
  • These results suggest that not only VEGFR-2-mediated signal but also VEGFR-3-mediated signal may contribute to proliferation of vascular tumor cells as autocrine and paracrine signaling factors.
  • [MeSH-major] Head and Neck Neoplasms / metabolism. Hemangiosarcoma / metabolism. Scalp / metabolism. Vascular Endothelial Growth Factor A / metabolism. Vascular Endothelial Growth Factor C / metabolism. Vascular Endothelial Growth Factor Receptor-2 / metabolism. Vascular Endothelial Growth Factor Receptor-3 / metabolism

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 19913279.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclin A; 0 / Cyclin E; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Ki-67 Antigen; 0 / Vascular Endothelial Growth Factor A; 0 / Vascular Endothelial Growth Factor C; EC 2.7.10.1 / Vascular Endothelial Growth Factor Receptor-2; EC 2.7.10.1 / Vascular Endothelial Growth Factor Receptor-3
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38. Kreusel KM: Ophthalmological manifestations in VHL and NF 1: pathological and diagnostic implications. Fam Cancer; 2005;4(1):43-7
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  • Capillary retinal angioma, a benign vascular tumor, is the classical ocular lesion in VHL.
  • It often appears as the first manifestation of the disease and may thus lead to the diagnosis of VHL.
  • Extension of the tumor beyond the chiasm worsens the prognosis quoad vitam.
  • The hallmark of NF 1, namely cutaneous neurofibroma can cause visual impairment when affecting the skin of the eyelids.
  • [MeSH-major] Hemangioma / etiology. Neurofibromatosis 1 / complications. Neurofibromatosis 1 / diagnosis. Optic Nerve Glioma / etiology. Retinal Neoplasms / etiology. von Hippel-Lindau Disease / complications. von Hippel-Lindau Disease / diagnosis

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  • (PMID = 15883709.001).
  • [ISSN] 1389-9600
  • [Journal-full-title] Familial cancer
  • [ISO-abbreviation] Fam. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 63
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39. Zhang Z, Chen HJ, Yang WJ, Bu H, Wei B, Long XY, Fu J, Zhang R, Ni YB, Zhang HY: Infantile hepatic hemangioendothelioma: a clinicopathologic study in a Chinese population. World J Gastroenterol; 2010 Sep 28;16(36):4549-57
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  • The tumor was presented with different clinical manifestations, mainly as an asymptomatic, palpable, upper abdominal mass, except for the two fetuses who were detected antenatally by ultrasound.
  • No symptoms of congestive heart failure were present and neither congenital abnormalities nor vascular tumors in the skin or other organs were found.
  • Based on radiological findings and gross specimens, the tumor presented as a solitary lesion or a multifocal space-occupying lesion.
  • The tumor size ranged from 5.0 cm × 3.5 cm × 2.0 cm to 13.8 cm × 9.0 cm × 7.7 cm, and the 0.2-1.1 cm nodules were diffusely distributed within the multifocal tumor.
  • An inflammatory component, predominantly eosinophilic granulocytes, sometimes obscured the nature of the tumor.

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  • (PMID = 20857525.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2945486
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40. Ilyas EN, Seykora JT, Heymann WR: Acquired agminated acral angioma: a novel vascular lesion. Arch Dermatol; 2005 May;141(5):646-7
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  • [Title] Acquired agminated acral angioma: a novel vascular lesion.
  • [MeSH-major] Hemangioma / pathology. Leg. Skin Neoplasms / pathology

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  • (PMID = 15897399.001).
  • [ISSN] 0003-987X
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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41. Fulkerson DH, Agim NG, Al-Shamy G, Metry DW, Izaddoost SA, Jea A: Emergent medical and surgical management of mediastinal infantile hemangioma with symptomatic spinal cord compression: case report and literature review. Childs Nerv Syst; 2010 Dec;26(12):1799-805
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  • [Title] Emergent medical and surgical management of mediastinal infantile hemangioma with symptomatic spinal cord compression: case report and literature review.
  • PURPOSE: We report an extremely rare case of a patient with a large, cervical, and upper thoracic cutaneous hemangioma associated with a separate, underlying mediastinal hemangioma extending to the epidural space causing significant spinal cord compression.
  • CONCLUSION: While several recent reports have described dramatic responses of hemangiomas to propranolol, this is the first case in which it was used as part of a multimodal approach to symptomatic spinal cord compression.
  • She is neurologically intact and has radiographic regression of the hemangiomas on follow-up examination 6 months later.
  • [MeSH-major] Decompression, Surgical / adverse effects. Hemangioma, Capillary / drug therapy. Hemangioma, Capillary / surgery. Mediastinal Neoplasms / drug therapy. Mediastinal Neoplasms / surgery. Spinal Cord Compression / surgery

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  • (PMID = 20405131.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Adrenergic beta-Antagonists; 0 / Anti-Inflammatory Agents; 0 / Anticoagulants; 9005-49-6 / Heparin; 9PHQ9Y1OLM / Prednisolone; 9Y8NXQ24VQ / Propranolol
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42. Woldemeskel M, Rajeev S: Mast cells in canine cutaneous hemangioma, hemangiosarcoma and mammary tumors. Vet Res Commun; 2010 Feb;34(2):153-60
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  • [Title] Mast cells in canine cutaneous hemangioma, hemangiosarcoma and mammary tumors.
  • Mast cell count (MCC) in 45 dogs with cutaneous hemangioma (HA, n = 12), hemangiosarcoma (HSA, n = 12), mammary adenoma (AD, n = 9) and mammary adenocarcinoma (AC, n = 12) was made using Toluidine blue stained sections.
  • This study suggests that mast cells may play an important role in neovascularization of canine cutaneous vascular and mammary neoplasms.
  • [MeSH-major] Dog Diseases / pathology. Hemangioma / veterinary. Hemangiosarcoma / veterinary. Mammary Neoplasms, Animal / pathology. Mast Cells / pathology. Mastocytosis / veterinary. Skin Neoplasms / veterinary
  • [MeSH-minor] Adenocarcinoma / blood supply. Adenocarcinoma / pathology. Adenocarcinoma / veterinary. Adenoma / blood supply. Adenoma / pathology. Adenoma / veterinary. Animals. Cell Count / veterinary. Dogs. Factor VIII / metabolism. Female. Immunohistochemistry / veterinary. Neovascularization, Pathologic / metabolism. Neovascularization, Pathologic / pathology. Neovascularization, Pathologic / veterinary. Vascular Endothelial Growth Factor A / metabolism

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  • (PMID = 20127412.001).
  • [ISSN] 1573-7446
  • [Journal-full-title] Veterinary research communications
  • [ISO-abbreviation] Vet. Res. Commun.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Vascular Endothelial Growth Factor A; 9001-27-8 / Factor VIII
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43. Badia MC, Chamarro R, Làinez JM, Piera A: [Proteus syndrome with cerebral vascular malformations]. Neurologia; 2006 Mar;21(2):88-91
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  • [Title] [Proteus syndrome with cerebral vascular malformations].
  • [Transliterated title] Síndrome de Proteus con malformaciones vasculares cerebrales.
  • This sporadic disorder involves the skeletal system, soft tissues, skin and vascular system.
  • Main manifestations included soft-tissue and epidermal nevi, partial gigantism, hemihypertrophy, exostoses, lipomas and vascular anomalies.
  • We present a case of Proteus syndrome with cerebral vascular anomalies which are not described previously.
  • Vascular tumors in the skin of trunk and left limb.
  • He also has brain vascular malformations which are not described previously in the literature.
  • We consider that both findings are not a product of causality due to the high prevalence of systemic vascular hamartomatous malformations in these patients.
  • We hypothesize that a single mutation, probably involving genes in relation with apoptotic control will be responsible of Proteus syndrome and cerebral vascular anomalies in our patient, due to a defect of angiogenesis.

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  • (PMID = 16525914.001).
  • [ISSN] 0213-4853
  • [Journal-full-title] Neurología (Barcelona, Spain)
  • [ISO-abbreviation] Neurologia
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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44. Martin L, Piette F, Blanc P, Mortier L, Avril MF, Delaunay MM, Dréno B, Granel F, Mantoux F, Aubin F, Sassolas B, Adamski H, Dalac S, Pauwels C, Dompmartin A, Lok C, Estève E, Guillot B, French Group for Cutaneous Oncology: Clinical variants of the preprotuberant stage of dermatofibrosarcoma protuberans. Br J Dermatol; 2005 Nov;153(5):932-6
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  • BACKGROUND: Some cases of dermatofibrosarcoma protuberans (DFSP) do not protrude above the skin.
  • They were asked to complete a standardized questionnaire indicating the history and appearance of the DFSP from the first skin changes identified to the time of diagnosis.
  • Twenty-nine per cent of npDFSPs were 'morphoea-like', 19% were 'atrophoderma-like' and 42% were 'angioma-like'.
  • Age at diagnosis was similar for both initial presentations. npDFSPs were most often misdiagnosed by physicians.
  • CONCLUSIONS: Nearly half the patients first identified their early DFSP-related skin changes as patches.
  • Both this frequency and the long duration at this preprotuberant stage should prompt dermatologists to consider the diagnosis of DFSP earlier, in order to make surgical treatment easier.
  • [MeSH-major] Dermatofibrosarcoma / pathology. Skin Neoplasms / pathology

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  • (PMID = 16225602.001).
  • [ISSN] 0007-0963
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] England
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45. Stalder JF: [What's new in pediatric dermatology?]. Ann Dermatol Venereol; 2007 Dec;134 Suppl 1:8S36-52
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  • [Transliterated title] Quoi de neuf en dermatologie pédiatrique ?
  • The treatment of severe forms of angioma, such as hemangioma and vascular dysplasia were also dealt with.
  • Genetic diseases with a cutaneous expression were the basis for many publications.
  • [MeSH-major] Dermatologic Agents / therapeutic use. Dermatology / trends. Pediatrics / trends. Skin Diseases / drug therapy
  • [MeSH-minor] Administration, Cutaneous. Adolescent. Child. Child, Preschool. Dermatitis, Atopic / drug therapy. Dermatomyositis / drug therapy. Environmental Exposure / adverse effects. Evidence-Based Medicine. Hemangioma / drug therapy. Humans. Infant. Medication Adherence. Pemphigoid, Bullous / drug therapy. Risk Factors. Scleroderma, Localized / drug therapy. Treatment Outcome

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  • (PMID = 18675140.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Dermatologic Agents
  • [Number-of-references] 61
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46. Astner S, González S, Cuevas J, Röwert-Huber J, Sterry W, Stockfleth E, Ulrich M: Preliminary evaluation of benign vascular lesions using in vivo reflectance confocal microscopy. Dermatol Surg; 2010 Jul;36(7):1099-110
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  • [Title] Preliminary evaluation of benign vascular lesions using in vivo reflectance confocal microscopy.
  • BACKGROUND: Reflectance confocal microscopy (RCM) is a novel noninvasive imaging technique for in vivo evaluation of cutaneous lesions at near-histologic resolution.
  • The applicability of RCM for various neoplastic and inflammatory skin diseases has been shown, but a descriptive evaluation of different vascular lesions has not yet been performed.
  • OBJECTIVES: To define specific RCM criteria for congenital and acquired vascular lesions and to determine whether these criteria may assist in their differential diagnosis.
  • MATERIALS AND METHODS: Seven patients with a clinical diagnosis of vascular lesion, including spider angioma, venous lake, cherry angioma, pyogenic granuloma, port wine stain, angiokeratoma, and lymphangioma, participated in this study.
  • Skin sites were systematically analyzed using RCM, and biopsy was obtained for clinically indeterminate lesions.
  • The most relevant criteria included the diameter of the vessels and degree of vascular tortuosity or dilation.
  • CONCLUSION: The findings of this preliminary evaluation indicate that RCM may aid in the noninvasive characterization of inflammatory, proliferative, and ectatic vascular malformations in vivo.
  • [MeSH-major] Granuloma, Pyogenic / pathology. Lymphangioma / pathology. Microscopy, Confocal / methods. Neoplasms, Vascular Tissue / pathology. Port-Wine Stain / pathology. Skin Neoplasms / pathology

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  • (PMID = 20653723.001).
  • [ISSN] 1524-4725
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Controlled Clinical Trial; Journal Article
  • [Publication-country] United States
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47. Ma HJ, Zhao G, Li Y, Li DG: Tufted angioma presented with segmental hyperpigmented plaque in a young Chinese woman. J Dermatol; 2010 Feb;37(2):190-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tufted angioma presented with segmental hyperpigmented plaque in a young Chinese woman.
  • [MeSH-major] Hemangioma / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 20175859.001).
  • [ISSN] 1346-8138
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Vimentin
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48. Liao M, Zhao J, Chen S, Wei Q, Yin G, Liu Q: [Research on laser and photodynamic therapy of skin hemangioma model-comb]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi; 2008 Dec;22(12):1437-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Research on laser and photodynamic therapy of skin hemangioma model-comb].
  • OBJECTIVE: To explore the mechanism of laser and photodynamic therapy (PDT) of hemangioma.
  • But in the other groups, tissue exudation, edema, inflammatory cell exudation, decreasing number of vessels, waning vascular caliber, thrombus, and partial capillary endothelium apoptosis were found.
  • CONCLUSION: Apoptosis of capillary endothelium maybe play an important role in the laser and photodynamic therapy of hemangioma apart from the direct effect of laser.
  • [MeSH-major] Hemangioma, Capillary / therapy. Neoplasms, Experimental / therapy. Skin Neoplasms / therapy
  • [MeSH-minor] Animals. Chickens. Laser Therapy. Male. Photochemotherapy. Skin / blood supply

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  • (PMID = 19137884.001).
  • [ISSN] 1002-1892
  • [Journal-full-title] Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
  • [ISO-abbreviation] Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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49. Udhrain A, Skubitz KM, Northfelt DW: Pegylated liposomal doxorubicin in the treatment of AIDS-related Kaposi's sarcoma. Int J Nanomedicine; 2007;2(3):345-52
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  • Kaposi's sarcoma is a vascular tumor of skin and viscera first described in 1872.
  • Compelling preclinical and clinical evidence, reviewed herein, has demonstrated that the nanoparticle (pegylated liposome) delivery system of this formulation leads to greater tumor localization of doxorubicin and consequent improved efficacy, as well as reduced toxicity.

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  • (PMID = 18019833.001).
  • [ISSN] 1176-9114
  • [Journal-full-title] International journal of nanomedicine
  • [ISO-abbreviation] Int J Nanomedicine
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] New Zealand
  • [Chemical-registry-number] 0 / Drug Carriers; 0 / Liposomes; 30IQX730WE / Polyethylene Glycols
  • [Number-of-references] 35
  • [Other-IDs] NLM/ PMC2676669
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50. Morrow SA, Campbell C: The cutaneous angioma of Sturge-Weber syndrome. Can J Neurol Sci; 2008 Sep;35(4):506-7
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  • [Title] The cutaneous angioma of Sturge-Weber syndrome.
  • [MeSH-major] Skin Neoplasms / pathology. Sturge-Weber Syndrome / pathology


51. Boncoraglio GB, Parati EA, Ciceri E, Rinaldi R, Capella GL: Intracranial cavernoma and speckled lentiginous nevus: extending the spectrum of phakomatoses? Neurol Sci; 2010 Dec;31(6):841-4
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  • [Title] Intracranial cavernoma and speckled lentiginous nevus: extending the spectrum of phakomatoses?
  • Phakomatosis refers to several malformation syndromes with simultaneous involvement of the skin, the eye, and the central nervous system by developmental lesions.
  • Speckled lentiginous nevus (SLN), a subtype of congenital melanocytic nevi, is usually an isolate, harmless finding.
  • Here, we report the case of a 52-year-old woman with congenital left laterocervical SLN associated with an ipsilateral intracranial extra-axial cavernous angioma, a yet not described association to date.
  • We also propose that patients with bizarre, geometrical, pigmented or vascular cervicocranial skin lesions should undergo a thorough neurologic and ophthalmologic evaluation.
  • [MeSH-major] Hemangioma, Cavernous, Central Nervous System / diagnosis. Neurocutaneous Syndromes / diagnosis. Nevus, Pigmented / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Middle Aged. Syndrome

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  • [CommentIn] Neurol Sci. 2012 Apr;33(2):477; author reply 479 [22044989.001]
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  • (PMID = 20842398.001).
  • [ISSN] 1590-3478
  • [Journal-full-title] Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
  • [ISO-abbreviation] Neurol. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
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52. Smolinski KN, Yan AC: Hemangiomas of infancy: clinical and biological characteristics. Clin Pediatr (Phila); 2005 Nov-Dec;44(9):747-66
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  • [Title] Hemangiomas of infancy: clinical and biological characteristics.
  • Hemangiomas of infancy are common in the general pediatric population, are usually easily diagnosed, and generally do not require treatment.
  • However, a small but significant percentage of hemangiomas of infancy may develop complications, including infection or ulceration.
  • In addition, hemangiomas located in some anatomic regions may be associated with other anomalies and therefore require more careful monitoring and earlier intervention to prevent permanent sequelae.
  • This review focuses on distinguishing hemangiomas from vascular malformations and delineates the natural history of hemangiomas of infancy, with an emphasis on identifying those hemangiomas that require additional evaluation and closer follow-up.
  • In addition, several conditions that often present with cutaneous hemangiomas are described, including PHACES syndrome and neonatal hemangiomatosis.
  • Finally, an assessment is made of the current understanding of the biology of hemangioma proliferation and involution, including the role of endothelial growth factors and GLUT1, a new marker for hemangiomas of infancy.
  • [MeSH-major] Hemangioma

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  • [Copyright] Clin Pediatr. 2005;44:747-766.
  • (PMID = 16327961.001).
  • [ISSN] 0009-9228
  • [Journal-full-title] Clinical pediatrics
  • [ISO-abbreviation] Clin Pediatr (Phila)
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adrenal Cortex Hormones
  • [Number-of-references] 144
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53. Chiu CS, Yang LC, Hong HS, Kuan YZ: Treatment of a tufted angioma with intense pulsed light. J Dermatolog Treat; 2007;18(2):109-11
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  • [Title] Treatment of a tufted angioma with intense pulsed light.
  • Tufted angioma is a rare cutaneous angiomatous proliferation named because of its characteristic histologic pattern of grouped dermal capillary tufts.
  • We report an adult case of tufted angioma, with unusual presentation as annular plaques, which was alleviated after treatment with intense pulsed light in terms of both cosmetics and discomfort.
  • [MeSH-major] Hemangioma / diagnosis. Hemangioma / therapy. Skin Neoplasms / diagnosis. Skin Neoplasms / therapy
  • [MeSH-minor] Adult. Back / pathology. Diagnosis, Differential. Female. Humans. Neck / pathology. Phototherapy. Scalp / pathology


54. Deng ZH, Xu CD, Chen SN: Diagnosis and treatment of blue rubber bleb nevus syndrome in children. World J Pediatr; 2008 Feb;4(1):70-3
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  • [Title] Diagnosis and treatment of blue rubber bleb nevus syndrome in children.
  • BACKGROUND: Blue rubber bleb nevus syndrome (BRBNS) is characterized by distinctive vascular malformations of skin and the gastrointestinal tract, often leading to chronic anemia and intestinal bleeding.
  • We analyzed the clinical characteristics and treatment of this disorder in order to improve the diagnosis and treatment.
  • METHODS: Three patients with BRBNS treated at our hospital during 2002-2003 and 39 patients from the literature reported during 1965-2003 were reviewed in terms of the diagnosis and treatment.
  • BRBNS may be diagnosed as cutaneous cavernous hemangioma associated with the same lesion of the gastrointestinal tract and other organs.
  • RESULTS: Our 3 patients suffered from cutaneous angioma and gastrointestinal hemangioma.
  • In 39 patients reported in the literature, cutaneous angioma was observed in all of them, and gastrointestinal hemangioma in 31.
  • Cutaneous angioma was located on the surface of the skin, including body (93%), limbs (86%), hip (36%) and face (26%).
  • Gastrointestinal hemangioma was more common in the small intestine (100%) than in the colon (74%) and stomach (26%).
  • When the joint was involved by hemangioma, pathologic fracture or overgrowth of bone needed traction and amputation (1 patient respectively).
  • Its recurrence with new angioma in the gastrointestinal tract needs laser-steroid therapy.
  • [MeSH-major] Hemangioma / diagnosis. Intestinal Neoplasms / diagnosis. Skin Neoplasms / diagnosis. Vascular Malformations / diagnosis
  • [MeSH-minor] Abnormalities, Multiple / diagnosis. Blood Transfusion. Child. Child, Preschool. Endoscopy, Gastrointestinal. Humans. Male. Melena / etiology. Nevus, Blue. Sclerotherapy. Syndrome

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  • (PMID = 18402258.001).
  • [ISSN] 1708-8569
  • [Journal-full-title] World journal of pediatrics : WJP
  • [ISO-abbreviation] World J Pediatr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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55. Reddy IS, Anuradha SV, Swarnalata G: Congenital giant tufted angioma. Indian J Dermatol Venereol Leprol; 2009 Nov-Dec;75(6):639
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  • [Title] Congenital giant tufted angioma.
  • [MeSH-major] Hemangioma / pathology. Neoplasms / pathology. Severity of Illness Index. Skin Neoplasms / pathology


56. O-Lee TJ, Messner A: Subglottic hemangioma. Otolaryngol Clin North Am; 2008 Oct;41(5):903-11, viii-ix
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  • [Title] Subglottic hemangioma.
  • Subglottic hemangioma is a rare condition that can be potentially life threatening because of airway obstruction.
  • It is common for subglottic hemangioma to be misdiagnosed as croup initially.
  • Infants with a subglottic hemangioma and cutaneous facial hemangiomas in a "beard" distribution should be evaluated for PHACE syndrome.
  • Endoscopic laser resection is effective for subglottic hemangioma but carries a chance of subglottic stenosis, up to 25%.
  • Open excision of subglottic hemangioma is an excellent option, particularly in patients with bilateral or circumferential subglottic hemangioma.
  • [MeSH-major] Hemangioma / diagnosis. Hemangioma / therapy. Laryngeal Neoplasms / diagnosis. Laryngeal Neoplasms / therapy

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  • (PMID = 18775341.001).
  • [ISSN] 0030-6665
  • [Journal-full-title] Otolaryngologic clinics of North America
  • [ISO-abbreviation] Otolaryngol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Glucocorticoids
  • [Number-of-references] 25
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57. Ramesh R, De Silva B, Atherton DJ: Congenital tufted angioma with persistent low-grade coagulopathy. Clin Exp Dermatol; 2009 Dec;34(8):e766-8
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  • [Title] Congenital tufted angioma with persistent low-grade coagulopathy.
  • A female infant, born with a tufted angioma, developed a coagulopathy with prolonged bleeding time, with the risk of progression to Kasabach-Merritt phenomenon.
  • [MeSH-major] Hemangioma / pathology. Skin Neoplasms / pathology


58. Alli SK, Adenuga OO, Ogbuagu MN, Velle LD, Akinyemi AO: Sturge-Weber syndrome in a 56 year old woman: a case report. Niger J Med; 2005 Jul-Sep;14(3):319-21
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  • BACKGROUND: Sturge-Weber syndrome is a sporadic phacomatoses with angiomas involving the leptomeninges and skin of the face, typically in the ophthalmic and maxillary distributions of the trigeminal nerve.
  • Presentation is typically at birth with a facial angioma.
  • METHOD: Case note of a patient with a diagnosis of Sturge-Weber syndrome was used and the relevant literature reviewed.
  • Examination of the left eye revealed a visual acuity of no light perception with episcleral haemangioma.
  • [MeSH-major] Sturge-Weber Syndrome / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Middle Aged

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  • (PMID = 16350708.001).
  • [ISSN] 1115-2613
  • [Journal-full-title] Nigerian journal of medicine : journal of the National Association of Resident Doctors of Nigeria
  • [ISO-abbreviation] Niger J Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Nigeria
  • [Number-of-references] 12
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59. Rader C, Piorkowski J, Bass DM, Babigian A: Epulis gravidarum manum: pyogenic granuloma of the hand occurring in pregnant women. J Hand Surg Am; 2008 Feb;33(2):263-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Pyogenic granuloma, also known as lobular capillary hemangioma, is a benign vascular tumor of the skin and mucous membranes.
  • These tumors failed to resolve spontaneously postpartum necessitating surgical removal.
  • We propose the term epulis gravidarum manum to describe this skin lesion.
  • [MeSH-major] Granuloma, Pyogenic / pathology. Hand / pathology. Pregnancy Complications / pathology. Skin Diseases / pathology


60. Rosbe KW, Suh KY, Meyer AK, Maguiness SM, Frieden IJ: Propranolol in the management of airway infantile hemangiomas. Arch Otolaryngol Head Neck Surg; 2010 Jul;136(7):658-65
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Propranolol in the management of airway infantile hemangiomas.
  • OBJECTIVE: To report our experience with propranolol in managing airway infantile hemangiomas.
  • DESIGN: Case series of 3 consecutive patients who had extensive, symptomatic airway infantile hemangiomas treated with propranolol.
  • PATIENTS: Three infants with facial cutaneous hemangiomas who developed stridor that progressed to respiratory distress, which according to laryngoscopic examination results was confirmed to be caused by extensive subglottic hemangiomas.
  • RESULTS: Patient 1 failed to respond to systemic corticosteroids, laser ablation, and intravenous vincristine for her airway hemangioma and had to undergo tracheotomy.
  • Patient 2 developed progressive stridor secondary to airway hemangioma at age 6 1/2 months following tapering of systemic corticosteroids prescribed for her periorbital hemangioma.
  • CONCLUSIONS: Our 3 patients had severe respiratory symptoms related to their airway infantile hemangiomas.
  • [MeSH-major] Adrenal Cortex Hormones / therapeutic use. Glottis / pathology. Hemangioma / drug therapy. Laryngeal Neoplasms / drug therapy. Propranolol / therapeutic use
  • [MeSH-minor] Airway Obstruction / congenital. Airway Obstruction / therapy. Combined Modality Therapy. Drug Therapy, Combination. Female. Follow-Up Studies. Humans. Infant. Infant, Newborn. Laryngoscopy. Male. Risk Assessment. Sampling Studies. Skin Neoplasms / congenital. Skin Neoplasms / diagnosis. Skin Neoplasms / therapy. Tracheostomy / methods. Treatment Outcome


61. Zheng JW, Wang YA, Zhou GY, Zhu HG, Ye WM, Zhang ZY: [Head and neck hemangiomas: how and when to treat]. Shanghai Kou Qiang Yi Xue; 2007 Aug;16(4):337-42
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  • [Title] [Head and neck hemangiomas: how and when to treat].
  • Hemangiomas are common benign vascular tumors of infancy characterized by a proliferative growth phase followed by very slow inevitable regression (involutive phase) between one to ten years of age, about 60% to 70% of the lesions are found in the head and neck region.
  • There are many treatment modalities reported in the literature for head and neck hemangiomas, including wait and see policy, drug therapy, sclerotherapy (steroids, bleomycin), cryotherapy, isotope radiotherapy, laser therapy, and surgical therapy.
  • Based on our clinical experience on 250 cases and literature review, a rational treatment regime for head and neck hemangioma was proposed in this study:.
  • (1) As it is not possible to predict, whether a hemangioma will remain small and unproblematic or grow into a very large lesion, early therapy is the only way out of this dilemma.
  • A white or pink macule, a port-wine stain-like lesion initially appearing in the children can be effectively and easily removed by laser, thus preventing a growth in the size in the early stage. (2) The term of "wait and see" should be substituted by "close observation", and this approach should only be reserved for hemangiomas which are without visible growth or in the involutive phase. (3) Systematic drug therapy (steroids, interferon alpha-2a ) should be considered for large hemangioma, multiple hemangiomas, life-threatening hemangiomas and hemangiomas with complications such as ulceration, infection, bleeding, dysfunction, etc.
  • Congestive heart failure, consumptive coagulopathy, and thrombocytopenia are also urgent indications for the institution of corticoid therapy. (4) Growing hemangioma can be treated effectively by systematic drug therapy, sclerotherapy, laser therapy or combined therapy.
  • The argon laser (514 nm in wavelength, 0.5 mm in depth) is useful in the treatment of superficial telangiectasias and small, flat cutaneous hemangiomas.
  • Flashlamp-pumped pulsed-dye laser (FPDL, 585 nm or 595 nm in wavelength, 1.0-2.0 mm in depth) can be used in patients with cutaneous and flat hemangiomas at the sites of potential functional impairment.
  • Nd: YAG laser (1064 nm in wavelength) with continuous ice cube cooling is useful for subcutaneous or mixed hemangiomas, and often requires repeated treatments.
  • For larger and deeper hemangiomas up to a depth of 2.0 cm, percutaneous interstitial Nd:YAG laser treatment may be preferred, because it may decrease possible cutaneous skin damage and more effectively reduce bulky, deep lesion. (5) Topical application of imiquimoid and intratumoral injection of steroids or bleomycin can be used in selected patients with rapidly growing hemangioma. (6) The indication for a primary operation is rare and limited to large hemangiomas in the eyelid or hemangiomas on the scalp.
  • The aim of treatment is to counter the proliferative growth, reduce the volume of hemangioma, and initialize the process of regression.
  • Cryotherapy or isotope radiotherapy is nowadays seldom used for the treatment of hemangiomas, due to the high incidence of scarring, pigmentation, or depigmentation.
  • A successful treatment of hemangiomas should be individualized and based on the size of the tumor, the localization, and the therapies available.
  • [MeSH-major] Head and Neck Neoplasms / therapy. Hemangioma / therapy

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  • (PMID = 17924011.001).
  • [ISSN] 1006-7248
  • [Journal-full-title] Shanghai kou qiang yi xue = Shanghai journal of stomatology
  • [ISO-abbreviation] Shanghai Kou Qiang Yi Xue
  • [Language] chi
  • [Publication-type] Editorial; English Abstract
  • [Publication-country] China
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62. Omidvari S, Nezakatgoo N, Ahmadloo N, Mohammadianpanah M, Mosalaei A: Role of intralesional bleomycin in the treatment of complicated hemangiomas: prospective clinical study. Dermatol Surg; 2005 May;31(5):499-501
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  • [Title] Role of intralesional bleomycin in the treatment of complicated hemangiomas: prospective clinical study.
  • BACKGROUND: Hemangioma is the most common tumor of infancy.
  • Many different therapeutic modalities can be used in this tumor.
  • OBJECTIVE: To investigate the effect of a new method of treatment (intralesional bleomycin injection) in complicated hemangiomas.
  • MATERIALS AND METHODS: In the Department of Radiation Oncology at Nemazee Hospital in Shiraz, Iran, from April 1992 to October 1998, 32 patients with complicated hemangioma were treated with four to six courses of direct injection of bleomycin into the lesion.
  • CONCLUSION: Intralesional injection of bleomycin is an easy, safe, and effective therapeutic modality in complicated cutaneous hemangiomas.
  • [MeSH-major] Antibiotics, Antineoplastic / administration & dosage. Bleomycin / administration & dosage. Hemangioma / drug therapy. Skin Neoplasms / drug therapy

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  • (PMID = 15962730.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 11056-06-7 / Bleomycin
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63. Mayer V, Maetzke J, Scharffetter-Kochanek K: [Punctate maculae on the back of the hands of a 44-year-old woman]. Hautarzt; 2009 May;60(5):428-32
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  • Our differential diagnosis includes idiopathic teleangiectases, teleangiectasia eruptiva perstans, angioma serpiginosum and angiokeratoma corporis diffusum Fabry.
  • Microscopic examination showed increased numbers of the small vessels of the upper vascular plexus with dilated capillaries.
  • This coupled with the clinical findings led us to the diagnosis of angioma serpiginosum with symmetrical distribution involving the shoulder girdle, upper aspects of the arms, and the backs of the hands.
  • [MeSH-major] Angiokeratoma / complications. Angiokeratoma / diagnosis. Hand / pathology. Keratosis / diagnosis. Keratosis / etiology. Macula Lutea / pathology. Skin Neoplasms / complications. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans

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  • (PMID = 19225742.001).
  • [ISSN] 1432-1173
  • [Journal-full-title] Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
  • [ISO-abbreviation] Hautarzt
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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64. Nakashima T, Jinnin M, Etoh T, Fukushima S, Masuguchi S, Maruo K, Inoue Y, Ishihara T, Ihn H: Down-regulation of mir-424 contributes to the abnormal angiogenesis via MEK1 and cyclin E1 in senile hemangioma: its implications to therapy. PLoS One; 2010;5(12):e14334
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Down-regulation of mir-424 contributes to the abnormal angiogenesis via MEK1 and cyclin E1 in senile hemangioma: its implications to therapy.
  • BACKGROUND: Senile hemangioma, so-called cherry angioma, is known as the most common vascular anomalies specifically seen in the aged skin.
  • METHODOLOGY/PRINCIPAL FINDINGS: In this study, we found that senile hemangioma consisted of clusters of proliferated small vascular channels in upper dermis, indicating that this tumor is categorized as a vascular tumor.
  • We then investigated the mechanism of endothelial proliferation in senile hemangioma, focusing on microRNA (miRNA).
  • miRNA PCR array analysis revealed the mir-424 level in senile hemangioma was lower than in other vascular anomalies.
  • Protein expression of MEK1 and cyclin E1, the predicted target genes of mir-424, was increased in senile hemangioma compared to normal skin or other anomalies, but their mRNA levels were not.
  • CONCLUSIONS/SIGNIFICANCE: Taken together, decreased mir-424 expression and increased levels of MEK1 or cyclin E1 in senile hemangioma may cause abnormal cell proliferation in the tumor.
  • Senile hemangioma may be the good model for cutaneous angiogenesis.
  • Investigation of senile hemangioma and the regulatory mechanisms of angiogenesis by miRNA in the aged skin may lead to new treatments using miRNA by the transfection into senile hemangioma.
  • [MeSH-major] Cyclin E / biosynthesis. Gene Expression Regulation. Hemangioma / enzymology. MAP Kinase Kinase 1 / biosynthesis. MicroRNAs / biosynthesis. Oncogene Proteins / biosynthesis

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  • (PMID = 21179471.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CCNE1 protein, human; 0 / Cyclin E; 0 / MIRN424 microrna, human; 0 / MicroRNAs; 0 / Oncogene Proteins; 0 / RNA, Messenger; EC 2.7.12.2 / MAP Kinase Kinase 1
  • [Other-IDs] NLM/ PMC3001869
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65. Ardighieri L, Lonardi S, Vermi W, Medicina D, Cerroni L, Facchetti F: Intralymphatic atypical T-cell proliferation in a cutaneous hemangioma. J Cutan Pathol; 2010 Apr;37(4):497-503
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  • [Title] Intralymphatic atypical T-cell proliferation in a cutaneous hemangioma.
  • We report an unusual case of atypical T-cell proliferation involving the lymphatic vessels within a cutaneous hemangioma from an elderly woman.
  • Despite the blastic morphology, the CD4 restricted phenotype and the very high proliferation index, the clinical presentation (single skin lesion in a healthy woman), the benign clinical course and the absence of T-cell receptor (TCR) clonal rearrangement favored a reactive nature of the process.
  • [MeSH-major] Cell Proliferation. Hemangioma / immunology. Lymph Nodes / immunology. Skin Neoplasms / immunology. T-Lymphocytes / immunology

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  • (PMID = 19614995.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Forkhead Transcription Factors; 0 / Receptors, Antigen, T-Cell
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66. Stockman A, Boralevi F, Taïeb A, Léauté-Labrèze C: SACRAL syndrome: spinal dysraphism, anogenital, cutaneous, renal and urologic anomalies, associated with an angioma of lumbosacral localization. Dermatology; 2007;214(1):40-5
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  • [Title] SACRAL syndrome: spinal dysraphism, anogenital, cutaneous, renal and urologic anomalies, associated with an angioma of lumbosacral localization.
  • BACKGROUND: Publications concerning perineal infantile hemangiomas are scarce, and comprise no large series.
  • OBJECTIVE: Studying clinical features of hemangiomas of the perineal area, complications and associated malformations.
  • METHODS: Retrospective analysis of all hemangiomas localized in the perineal area, encountered at the Children's Hospital in Bordeaux from 1994.
  • RESULTS: Of 49 perineal hemangiomas (34 girls, 15 boys), 5 patients had accompanying malformation, mainly lipomyelomeningocele with tethered cord.
  • The superficial hemangiomas were more represented in males and presented sooner than the nodular counterpart.
  • CONCLUSION: Superficial perineal hemangiomas are more often complicated by ulceration, and are associated with developmental anomalies.
  • As a counterpart for the PHACE syndrome in facial hemangioma, we propose the acronym SACRAL for perineal hemangiomas: Spinal dysraphism, Anogenital anomalies, Cutaneous anomalies, Renal and urologic anomalies, associated with Angioma of Lumbosacral localization.
  • [MeSH-major] Anal Canal / abnormalities. Hemangioma / complications. Skin Abnormalities / complications. Spinal Dysraphism / complications. Urogenital Abnormalities / complications
  • [MeSH-minor] Diagnosis, Differential. Female. France / epidemiology. Humans. Incidence. Infant. Infant, Newborn. Lumbosacral Plexus. Male. Perineum. Retrospective Studies. Sex Distribution. Syndrome

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  • [CommentIn] Dermatology. 2007;215(4):360; author reply 360-1 [17911998.001]
  • (PMID = 17191046.001).
  • [ISSN] 1018-8665
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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67. Pascual-Castroviejo I, Viaño J, Pascual-Pascual SI, Quiñones D: Congenital and evolving vascular disorders associated with cutaneous hemangiomas: case report. Neuropediatrics; 2009 Jun;40(3):148-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Congenital and evolving vascular disorders associated with cutaneous hemangiomas: case report.
  • [MeSH-major] Cardiovascular Abnormalities / complications. Cerebrovascular Disorders / complications. Hemangioma / congenital. Skin Neoplasms / complications

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  • (PMID = 20020403.001).
  • [ISSN] 1439-1899
  • [Journal-full-title] Neuropediatrics
  • [ISO-abbreviation] Neuropediatrics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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68. CEDEF: [Item 223: hemangioma of the skin]. Ann Dermatol Venereol; 2008 Nov;135(11 Suppl):F181-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Item 223: hemangioma of the skin].
  • [MeSH-major] Hemangioma / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Arteriovenous Malformations / diagnosis. Diagnosis, Differential. Humans

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  • (PMID = 18984212.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] Journal Article
  • [Publication-country] France
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69. Guillou L: [Mesenchymal tumors of the skin. Tufted angioma (angioblastoma)]. Ann Pathol; 2009 Oct;29(5):416-9
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  • [Title] [Mesenchymal tumors of the skin. Tufted angioma (angioblastoma)].
  • [Transliterated title] Tumeurs conjonctives de la peau. Cas n(o) 8. Hémangiome acquis en touffes (angioblastome de Nakagawa).
  • [MeSH-major] Hemangioma / pathology. Skin Neoplasms / pathology


70. Eggers G, Flechtenmacher C, Kurzen H, Hassfeld S: Infiltrating basal cell carcinoma of the neck 34 years after irradiation of an haemangioma in early childhood. A case-report. J Craniomaxillofac Surg; 2005 Jun;33(3):197-200
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  • [Title] Infiltrating basal cell carcinoma of the neck 34 years after irradiation of an haemangioma in early childhood. A case-report.
  • Thirty years ago the patient had undergone radiotherapy for an infantile haemangioma of the skin of the neck.
  • [MeSH-minor] Adult. Hemangioma / radiotherapy. Humans. Male. Skin Neoplasms / radiotherapy. Time Factors

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  • (PMID = 15878521.001).
  • [ISSN] 1010-5182
  • [Journal-full-title] Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
  • [ISO-abbreviation] J Craniomaxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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71. Kruse AL, Zwahlen R, Bredell MG, Riener MO, Grätz KW: Apocrine hidrocystoma of the cheek. J Craniofac Surg; 2010 Mar;21(2):594-6
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  • Malignant melanoma, eccrine hidrocystoma, angioma, and follicular cysts have to be considered as differential diagnoses.
  • An exocrine tumor or, more unlikely, a melanoma was considered as a differential diagnosis.
  • Therefore, knowledge of this benign entity in head and neck surgery including the differential diagnosis can prevent an unnecessarily large defect by too large margins.
  • [MeSH-major] Cheek / pathology. Facial Neoplasms / diagnosis. Hidrocystoma / diagnosis. Sweat Gland Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Follicular Cyst / diagnosis. Hemangioma / diagnosis. Humans. Male. Melanoma / diagnosis. Middle Aged. Skin Diseases / diagnosis

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  • (PMID = 20489460.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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72. Yuan RT, Jia MY, Feng YY, Shang W, Li NY: [Early laser intervention of hemangioma in facial and neck regions of infant]. Hua Xi Kou Qiang Yi Xue Za Zhi; 2008 Apr;26(2):166-7, 171
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  • [Title] [Early laser intervention of hemangioma in facial and neck regions of infant].
  • OBJECTIVE: The study was to evaluate the method of early laser intervention of hemangioma in facial and neck regions of infant.
  • METHODS: Between January 1999 and December 2006, twelve patients, aged 6 days to 3 months, with cutaneous hemangioma in facial and neck regions, were treated with laser, eight cases with Nd:YAG laser therapy and four cases with Venus laser therapy.
  • Four cases with hemangioma in facial and neck regions of infant treated with oral corticosteroid were as control.
  • Hemangiomas enlarged continuously in four cases with oral corticosteroid therapy.
  • CONCLUSION: Early laser intervention is an excellent management of cutaneous hemangioma in facial and neck regions of infant.
  • [MeSH-major] Hemangioma. Neck

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  • (PMID = 18605456.001).
  • [ISSN] 1000-1182
  • [Journal-full-title] Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology
  • [ISO-abbreviation] Hua Xi Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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73. Zambanini S, Sablatnig R, Maier H, Langs G: Automatic image-based assessment of lesion development during hemangioma follow-up examinations. Artif Intell Med; 2010 Oct;50(2):83-94
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Automatic image-based assessment of lesion development during hemangioma follow-up examinations.
  • OBJECTIVE: This paper presents an automatic method for the quantification of the development of cutaneous hemangiomas in digital images.
  • (1) the skin area affected by the lesion is measured and (2) the change of the hemangioma during follow-up examinations called regression is determined.
  • METHODS AND MATERIAL: The proposed method classifies individual pixels and calculates the area based on a ruler attached to the skin.
  • CONCLUSIONS: The results indicate that the proposed method provides an accurate and objective evaluation of the course of cutaneous hemangiomas.
  • [MeSH-major] Hemangioma / diagnosis. Skin Neoplasms / diagnosis

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  • [Copyright] Copyright © 2010 Elsevier B.V. All rights reserved.
  • (PMID = 20729044.001).
  • [ISSN] 1873-2860
  • [Journal-full-title] Artificial intelligence in medicine
  • [ISO-abbreviation] Artif Intell Med
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
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74. Gleizal A, Torossian JM, Geha H, Lebreton F, Beziat JL: [Testicular choriocarcinoma presenting as cutaneous metastasis. A case report and review of the literature]. Ann Chir Plast Esthet; 2005 Jun;50(3):237-41
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  • [Title] [Testicular choriocarcinoma presenting as cutaneous metastasis. A case report and review of the literature].
  • [Transliterated title] Les métastases cutanées révélatrices des choriocarcinomes: revue de la littérature. A propos d'une localisation nasale d'origine testiculaire.
  • Choriocarcinoma are germinal tumors from testicular cells in men or foetal trophoblast in women.
  • Cutaneous metastasis are very rare.
  • The authors report a case of angioma-like tumor in a 22-year-old man which was a cutaneous metastasis of a testicular carcinoma.
  • Diagnosis was of course histologic.
  • Testicular echography showed an intra testicular tumor, pulmonary and abdominal CT-scan showed multiple metastases.
  • Patient died 14 months after diagnosis.
  • Only 11 cases of cutaneous metastasis of choriocarcinoma were found in the world literature (7 men and 4 women).
  • All cases showed diagnosis trap for plastic surgeon.
  • [MeSH-major] Choriocarcinoma / secondary. Nose Neoplasms / secondary. Skin Neoplasms / secondary. Testicular Neoplasms / pathology


75. Terada N, Arakaki R, Okada Y, Kaneko Y, Nishimura K: Management of urethral hemangiomas associated with Klippel-Trenaunay-Weber syndrome by endoscopic sclerotherapy. Int J Urol; 2007 Jul;14(7):658-60
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  • [Title] Management of urethral hemangiomas associated with Klippel-Trenaunay-Weber syndrome by endoscopic sclerotherapy.
  • Klippel-Trenaunay-Weber syndrome (KTS) is an unusual congenital anomaly characterized by cutaneous hemangiomas, varicosities and bony hypertrophy of the extremities.
  • Herein the case is reported of a 24-year-old man with urethral bleeding from hemangiomas associated with KTS that were successfully managed by endoscopic sclerotherapy.
  • This is the first case reporting endoscopic sclerotherapy for a KTS-associated urethral hemangioma.
  • [MeSH-major] Endoscopy. Hemangioma / complications. Hemangioma / therapy. Klippel-Trenaunay-Weber Syndrome / complications. Sclerotherapy / methods. Urethral Neoplasms / complications. Urethral Neoplasms / therapy


76. Poenitz N, Koenen W, Utikal J, Goerdt S: [Angioma serpiginosum following the lines of Blaschko--an effective treatment with the IPL technology]. J Dtsch Dermatol Ges; 2006 Aug;4(8):650-3
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  • [Title] [Angioma serpiginosum following the lines of Blaschko--an effective treatment with the IPL technology].
  • [Transliterated title] Angioma serpiginosum in den Blaschkolinien--eine effektive Behandlung mit der IPL Technik.
  • Angioma serpiginosum, first described by Hutchinson in 1889, is a rare benign vascular nevus with dilatation and proliferation of the capillaries in the upper dermis.
  • A 15-year-old boy presented with an angioma serpiginosum on the right side of the body following the lines of Blaschko.
  • [MeSH-major] Hemangioma / pathology. Hemangioma / therapy. Phototherapy / methods. Skin Neoplasms / pathology. Skin Neoplasms / therapy

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  • (PMID = 16895567.001).
  • [ISSN] 1610-0379
  • [Journal-full-title] Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
  • [ISO-abbreviation] J Dtsch Dermatol Ges
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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77. Gruman A, Liang MG, Mulliken JB, Fishman SJ, Burrows PE, Kozakewich HP, Blei F, Frieden IJ: Kaposiform hemangioendothelioma without Kasabach-Merritt phenomenon. J Am Acad Dermatol; 2005 Apr;52(4):616-22
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  • Kasabach-Merritt phenomenon is a serious coagulopathy associated with kaposiform hemangioendothelioma (KHE), tufted angioma, and possibly other vascular neoplasms.
  • KHE presenting in the absence of Kasabach-Merritt phenomenon is rare, although tufted angioma frequently occurs without thrombocytopenia.
  • The tumors appeared as soft tissue masses with the overlying skin being either normal, erythematous, or violaceous.
  • All KHE were less than 8 cm in diameter, suggesting that tumors that grow no larger than this size are less likely to trap platelets in sufficient quantity to cause thrombocytopenia.
  • The decision as to whether or not to treat a noncoagulopathic KHE should be based on the size and location of the tumor and the possible side effects of therapy.
  • [MeSH-major] Hemangioendothelioma / diagnosis. Skin Neoplasms / diagnosis


78. Vlahovic A, Simic R, Djokic D, Ceran C: Diffuse neonatal hemangiomatosis treatment with cyclophosphamide: a case report. J Pediatr Hematol Oncol; 2009 Nov;31(11):858-60
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  • There were 63 cutaneous hemangiomas over the scalp, face, trunk, and extremities.
  • Computed tomography scan revealed the presence of hemangiomas in the liver and kidneys; laryngobronchoscopy identified the presence of hemangioma in tracheobronchial tree.
  • Magnetic resonance imaging of the abdomen revealed the marked decrease in size of the liver hemangioma.
  • [MeSH-major] Antineoplastic Agents, Alkylating / administration & dosage. Cyclophosphamide / administration & dosage. Hemangioma / drug therapy. Hemangioma / pathology. Mesna / administration & dosage. Protective Agents / administration & dosage

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  • (PMID = 19829152.001).
  • [ISSN] 1536-3678
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 0 / Protective Agents; 8N3DW7272P / Cyclophosphamide; NR7O1405Q9 / Mesna
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79. Noyes N, Porcu E, Borini A: Over 900 oocyte cryopreservation babies born with no apparent increase in congenital anomalies. Reprod Biomed Online; 2009 Jun;18(6):769-76
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  • Of the total 936 live borns, 1.3% (12) were noted to have birth anomalies: three ventricular septal defects, one choanal and one biliary atresia, one Rubinstein-Taybi syndrome, one Arnold-Chiari syndrome, one cleft palate, three clubfoot and one skin haemangioma.


80. Le Huu AR, Jokinen CH, Rubin BP, Mihm MC, Weiss SW, North PE, Dadras SS: Expression of prox1, lymphatic endothelial nuclear transcription factor, in Kaposiform hemangioendothelioma and tufted angioma. Am J Surg Pathol; 2010 Nov;34(11):1563-73
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of prox1, lymphatic endothelial nuclear transcription factor, in Kaposiform hemangioendothelioma and tufted angioma.
  • Kaposiform hemangioendothelioma (KHE) and tufted angioma (TA) are rare tumors mainly occurring in early childhood.
  • This dramatic Prox1-induced phenotype prompted us to investigate immunohistochemical staining pattern of Prox1, podoplanin (D2-40), LYVE-1, and Prox1/CD34 as well as double immunofluorescent staining pattern of LYVE-1/CD31 in KHE and TA, compared with other pediatric vascular tumors.
  • For this purpose, we examined 75 vascular lesions: KHE (n=18), TA (n=13), infantile hemangioma (n=13), pyogenic granuloma (n=18), and granulation tissue (n=13).
  • The lesional cells of all infantile hemangiomas and pyogenic granulomas were negative for Prox1 in the presence of positive internal control.
  • Overall, our results show, for the first time, that Prox1 is an immunohistochemical biomarker helpful in confirming the diagnosis of KHE/TA and in distinguishing it from infantile hemangioma and pyogenic granuloma.
  • [MeSH-major] Biomarkers, Tumor / analysis. Hemangioendothelioma / chemistry. Hemangioma / chemistry. Homeodomain Proteins / analysis. Skin Neoplasms / chemistry. Soft Tissue Neoplasms / chemistry. Tumor Suppressor Proteins / analysis
  • [MeSH-minor] Adolescent. Antigens, CD31 / analysis. Antigens, CD34 / analysis. Cell Nucleus / chemistry. Child. Child, Preschool. Cytoplasm / chemistry. Diagnosis, Differential. Granuloma, Pyogenic / metabolism. Humans. Immunohistochemistry. Immunophenotyping. Infant. Membrane Glycoproteins / analysis. Predictive Value of Tests. Vesicular Transport Proteins / analysis


81. Abe M, Misago N, Tanaka S, Masuoka J, Tabuchi K: Capillary hemangioma of the central nervous system: a comparative study with lobular capillary hemangioma of the skin. Acta Neuropathol; 2005 Feb;109(2):151-8
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  • [Title] Capillary hemangioma of the central nervous system: a comparative study with lobular capillary hemangioma of the skin.
  • Capillary hemangiomas have rarely been reported to develop in the brain or spinal cord.
  • Here we report the histological and immunohistochemical features of ten cases of central nervous system capillary hemangiomas (CNSCH) and compare these to those of lobular capillary hemangioma (LCH) of the skin.
  • These features were not statistically different from those of LCH of the skin, although the highly cellular area was more prominent and more frequent in cases of CNSCH.
  • Immunohistochemical studies demonstrated no positive staining of endothelial cells within either lesion for erythrocyte-type glucose transporter protein, which is a selective marker for capillary hemangioma of infancy.
  • Vascular endothelial growth factor immunostaining demonstrated positive cells in the solid or immature-appearing areas without vessel lumen formation in both lesions.
  • The MIB-1 index of CNSCH was variable (mean 5.6%) and the apoptotic index of CNSCH was significantly lower than that of LCH of the skin.
  • CNSCH are benign lesions with histological and immunohistochemical features similar to those of LCH of the skin.
  • [MeSH-major] Central Nervous System Neoplasms / pathology. Granuloma, Pyogenic / pathology. Hemangioma, Capillary / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Cell Death / physiology. Child. Endothelium / pathology. Female. Follow-Up Studies. Glucose Transporter Type 1. Humans. Immunohistochemistry / methods. In Situ Nick-End Labeling / methods. Ki-67 Antigen / metabolism. Male. Middle Aged. Monosaccharide Transport Proteins / metabolism. Staining and Labeling / methods. Vascular Endothelial Growth Factor A / metabolism

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  • (PMID = 15365728.001).
  • [ISSN] 0001-6322
  • [Journal-full-title] Acta neuropathologica
  • [ISO-abbreviation] Acta Neuropathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Glucose Transporter Type 1; 0 / Ki-67 Antigen; 0 / Monosaccharide Transport Proteins; 0 / SLC2A1 protein, human; 0 / Vascular Endothelial Growth Factor A
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82. Lok C, Viseux V, Avril MF, Richard MA, Gondry-Jouet C, Deramond H, Desfossez-Tribout C, Courtade S, Delaunay M, Piette F, Legars D, Dreno B, Saïag P, Longy M, Lorette G, Laroche L, Caux F, Cancerology Group of the French Society of Dermatology: Brain magnetic resonance imaging in patients with Cowden syndrome. Medicine (Baltimore); 2005 Mar;84(2):129-36
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Cowden syndrome (CS) is a rare autosomal dominant genodermatosis, characterized by multiple hamartomas, particularly of the skin, associated with high frequencies of breast, thyroid, and genitourinary malignancies.
  • Although Lhermitte-Duclos disease (LDD) or dysplastic gangliocytoma of the cerebellum, a slowly progressive unilateral tumor, is a major criterion of CS, its frequency in patients with CS is unknown.
  • Other cerebral abnormalities, especially meningioma and vascular malformations, have also been described, albeit rarely, in these patients.
  • Cerebral MRI revealed LDD in 3 patients, a meningioma in 1, and numerous vascular malformations in 6 patients.
  • Five patients had venous angiomas (3 associated with LDD) and 2 patients had cavernous angiomas (1 associated with LDD and a venous angioma).
  • The discovery of asymptomatic LDD in 3 patients and a cavernous angioma in another prompted us to perform neurologic examinations regularly and MRI to estimate the size and the extension of the tumor, and to assess the need for surgery.
  • CS similarities with Bannayan-Riley-Ruvalcaba (BRR) are discussed because some patients could also have the BRR phenotype (for example, genital lentigines, macrocephaly, multiple lipomas) and because BRR seems to have more central nervous system vascular anomalies.
  • Our findings confirm the contribution of brain MRI to detecting asymptomatic LDD, vascular malformations, and meningiomas in patients with CS.
  • [MeSH-minor] Adolescent. Adult. Aged. Central Nervous System Venous Angioma / complications. Central Nervous System Venous Angioma / pathology. Cerebellar Neoplasms / complications. Cerebellar Neoplasms / pathology. Child. Female. Ganglioneuroma / complications. Ganglioneuroma / pathology. Hemangioma / complications. Hemangioma / pathology. Humans. Male. Meningeal Neoplasms / complications. Meningeal Neoplasms / pathology. Meningioma / complications. Meningioma / pathology. Middle Aged. Mutation. PTEN Phosphohydrolase. Phosphoric Monoester Hydrolases / genetics. Tumor Suppressor Proteins / genetics

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  • (PMID = 15758842.001).
  • [ISSN] 0025-7974
  • [Journal-full-title] Medicine
  • [ISO-abbreviation] Medicine (Baltimore)
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Tumor Suppressor Proteins; EC 3.1.3.- / Phosphoric Monoester Hydrolases; EC 3.1.3.48 / PTEN protein, human; EC 3.1.3.67 / PTEN Phosphohydrolase
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83. Iacobas I, Burrows PE, Frieden IJ, Liang MG, Mulliken JB, Mancini AJ, Kramer D, Paller AS, Silverman R, Wagner AM, Metry DW: LUMBAR: association between cutaneous infantile hemangiomas of the lower body and regional congenital anomalies. J Pediatr; 2010 Nov;157(5):795-801.e1-7
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  • [Title] LUMBAR: association between cutaneous infantile hemangiomas of the lower body and regional congenital anomalies.
  • OBJECTIVE: To define the clinical spectrum of regional congenital anomalies associated with large cutaneous hemangiomas of the lower half of the body, clarify risk for underlying anomalies on the basis of hemangioma location, and provide imaging guidelines for evaluation.
  • RESULTS: Hemangiomas in our series tended to be "segmental" and often "minimal growth" in morphology.
  • Extensive limb hemangiomas also showed potential for extracutaneous anomalies, including underlying arterial anomalies, limb underdevelopment, and ulceration.
  • The cutaneous hemangioma and underlying anomalies demonstrated regional correlation.
  • CONCLUSIONS: We propose the acronym "LUMBAR" to describe the association of Lower body hemangioma and other cutaneous defects, Urogenital anomalies, Ulceration, Myelopathy, Bony deformities, Anorectal malformations, Arterial anomalies, and Renal anomalies.
  • [MeSH-major] Congenital Abnormalities. Hemangioma / complications. Skin Neoplasms / complications

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  • [Copyright] Copyright © 2010 Mosby, Inc. All rights reserved.
  • (PMID = 20598318.001).
  • [ISSN] 1097-6833
  • [Journal-full-title] The Journal of pediatrics
  • [ISO-abbreviation] J. Pediatr.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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84. Haddy N, Dondon MG, Paoletti C, Rubino C, Mousannif A, Shamsaldin A, Doyon F, Labbé M, Robert C, Avril MF, Demars R, Molinie F, Lefkopoulos D, Diallo I, de Vathaire F: Breast cancer following radiotherapy for a hemangioma during childhood. Cancer Causes Control; 2010 Nov;21(11):1807-16
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  • [Title] Breast cancer following radiotherapy for a hemangioma during childhood.
  • PURPOSE: A cohort study was performed to investigate the carcinogenic effect of treatment of skin hemangioma with ionizing radiation in early childhood.
  • METHODS AND MATERIALS: In an incidence study, 3,316 women treated for a skin hemangioma between 1941 and 1977 at the Institut Gustave-Roussy were included, among whom 2,697 had received radiotherapy.
  • CONCLUSION: This study confirms that radiation treatment performed in the past for hemangioma during childhood increases the risk of BC.
  • [MeSH-major] Breast Neoplasms / epidemiology. Breast Neoplasms / etiology. Hemangioma / radiotherapy. Neoplasms, Radiation-Induced / etiology. Skin Neoplasms / radiotherapy


85. Denoyelle F, Leboulanger N, Enjolras O, Harris R, Roger G, Garabedian EN: Role of Propranolol in the therapeutic strategy of infantile laryngotracheal hemangioma. Int J Pediatr Otorhinolaryngol; 2009 Aug;73(8):1168-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Role of Propranolol in the therapeutic strategy of infantile laryngotracheal hemangioma.
  • There are recent reports of effective treatment of cutaneous hemangiomas with Propranolol.
  • The current study aims to assess efficacy of systemic Propranolol for subglottic hemangiomas and to discuss its place among the other available therapies.
  • We report 2 infants with subglottic hemangiomas, which were resistant to other established medical treatments.
  • One infant presented with PHACES association, the other with widespread cutaneous congenital hemangiomas.
  • Both patients' subglottic hemangiomas responded dramatically to systemic Propranolol.
  • Propranolol appears to be an effective treatment for subglottic hemangiomas and should now be used as a first-line treatment in subglottic hemangiomas when intervention is required.
  • [MeSH-major] Adrenergic beta-Antagonists / therapeutic use. Hemangioma / drug therapy. Laryngeal Neoplasms / drug therapy. Propranolol / therapeutic use. Tracheal Neoplasms / drug therapy
  • [MeSH-minor] Abnormalities, Multiple. Female. Humans. Infant. Skin Neoplasms

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  • (PMID = 19481268.001).
  • [ISSN] 1872-8464
  • [Journal-full-title] International journal of pediatric otorhinolaryngology
  • [ISO-abbreviation] Int. J. Pediatr. Otorhinolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Adrenergic beta-Antagonists; 9Y8NXQ24VQ / Propranolol
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86. Hess CP, Fullerton HJ, Metry DW, Drolet BA, Siegel DH, Auguste KI, Gupta N, Haggstrom AN, Dowd CF, Frieden IJ, Barkovich AJ: Cervical and intracranial arterial anomalies in 70 patients with PHACE syndrome. AJNR Am J Neuroradiol; 2010 Nov;31(10):1980-6
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  • BACKGROUND AND PURPOSE: Cerebral and cervical arterial abnormalities are the most common non-cutaneous anomaly in PHACE syndrome, but the location and type of arterial lesions that occur have not been systematically assessed in a large cohort.
  • Our aim was to characterize the phenotypic spectrum of arteriopathy, assess the frequency with which different arteries are involved, and evaluate spatial relationships between arteriopathy, brain structural lesions, and hemangiomas in PHACE syndrome.
  • Univariate logistic regression analyses were performed to test for associations between arteriopathy location, hemangiomas, and brain abnormalities.
  • Hemangiomas were ipsilateral to arteriopathy in all but 1 case.
  • The frontotemporal and/or mandibular facial segments were involved in 97% of cases, but no other specific associations between arteriopathy location and hemangioma sites were detected.
  • CONCLUSIONS: The arteriopathy of PHACE syndrome commonly involves the ICA and its embryonic branches, ipsilateral to the cutaneous hemangioma, with dysgenesis and abnormal arterial course the most commonly noted abnormalities.
  • [MeSH-major] Carotid Artery, Internal / abnormalities. Hemangioma / pathology. Magnetic Resonance Angiography. Vascular Neoplasms / pathology

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  • (PMID = 20705698.001).
  • [ISSN] 1936-959X
  • [Journal-full-title] AJNR. American journal of neuroradiology
  • [ISO-abbreviation] AJNR Am J Neuroradiol
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / UL1 RR024140 01
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] PHACE association
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87. Rajaonarivony T, Randriamananjara N, Rakotoarisoa AJ, Rantomalala HY, Ranaivozanany A: [A case of Klippel-Trenaunay-Weber syndrome of the hand: description and review of the literature]. Ann Cardiol Angeiol (Paris); 2005 Sep;54(5):289-91
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  • [Transliterated title] Un cas de syndrome de Klippel-Trenaunay-Weber de la main: description et revue de la littérature.
  • The patient presented with cutaneous hemangioma, varicosities and unilateral hypertrophy of soft tissues of the left hand.
  • [MeSH-major] Klippel-Trenaunay-Weber Syndrome / diagnosis
  • [MeSH-minor] Arteriovenous Fistula / diagnosis. Arteriovenous Fistula / surgery. Arteriovenous Shunt, Surgical. Child. Female. Hand / pathology. Hemangioma / etiology. Hemangioma / surgery. Humans. Hypertrophy / etiology. Hypertrophy / surgery. Skin Neoplasms / etiology. Skin Neoplasms / surgery

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  • (PMID = 16237920.001).
  • [ISSN] 0003-3928
  • [Journal-full-title] Annales de cardiologie et d'angéiologie
  • [ISO-abbreviation] Ann Cardiol Angeiol (Paris)
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 11
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88. Nord KM, Kandel J, Lefkowitch JH, Lobritto SJ, Morel KD, North PE, Garzon MC: Multiple cutaneous infantile hemangiomas associated with hepatic angiosarcoma: case report and review of the literature. Pediatrics; 2006 Sep;118(3):e907-13
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  • [Title] Multiple cutaneous infantile hemangiomas associated with hepatic angiosarcoma: case report and review of the literature.
  • Multiple cutaneous hemangiomas can be associated with internal hemangiomas, with the liver being the most common site.
  • Here we report a case of a premature female neonate who presented with cardiac failure at birth and had typical-appearing infantile hemangiomas on the skin in association with vascular lesions in the liver.
  • Her clinical presentation was felt to be consistent with cutaneous and hepatic infantile hemangiomas.
  • Histopathologic evaluation of the liver revealed a diagnosis of type 2 infantile hepatic hemangioendothelioma (regarded as synonymous with angiosarcoma) rather than benign infantile hemangioma of the liver.
  • Subsequent skin biopsies confirmed that her multiple cutaneous lesions were infantile hemangiomas and not metastatic angiosarcoma.
  • We report this case and a review of the literature on pediatric angiosarcoma of the liver associated with cutaneous infantile hemangiomas.
  • [MeSH-major] Hemangioma / pathology. Hemangiosarcoma / pathology. Liver Neoplasms / pathology. Skin Neoplasms / pathology

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  • [ErratumIn] Pediatrics. 2007 Jun;119(6):1271
  • (PMID = 16880251.001).
  • [ISSN] 1098-4275
  • [Journal-full-title] Pediatrics
  • [ISO-abbreviation] Pediatrics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 27
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89. Boutarbouch M, Ben Salem D, Giré L, Giroud M, Béjot Y, Ricolfi F: Multiple cerebral and spinal cord cavernomas in Klippel-Trenaunay-Weber syndrome. J Clin Neurosci; 2010 Aug;17(8):1073-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Klippel-Trenaunay-Weber syndrome (KTWS) is a rare syndrome in which patients harbor cutaneous hemangiomas, venous varicosities, and osseous-soft tissue hypertrophy of the affected limb.
  • [MeSH-major] Cerebral Cortex / pathology. Hemangioma, Cavernous, Central Nervous System / complications. Klippel-Trenaunay-Weber Syndrome / complications. Spinal Cord / pathology

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  • [Copyright] Copyright 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20493710.001).
  • [ISSN] 1532-2653
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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90. Chen W, Liu TJ, Yang YC, Happle R: Angioma serpiginosum arranged in a systematized segmental pattern suggesting mosaicism. Dermatology; 2006;213(3):236-8
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  • [Title] Angioma serpiginosum arranged in a systematized segmental pattern suggesting mosaicism.
  • Histopathological examination showed dilated capillaries in the uppermost part of the dermal papillae characteristic of angioma serpiginosum.
  • The systematized, segmental and asymmetric arrangement of lesions as noted in the present case suggest that angioma serpiginosum reflects genetic mosaicism.
  • [MeSH-major] Mosaicism. Skin Diseases, Vascular / diagnosis. Telangiectasis / diagnosis

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  • (PMID = 17033175.001).
  • [ISSN] 1018-8665
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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91. Weidemann F, Strotmann JM, Breunig F, Niemann M, Maag R, Baron R, Eggert AO, Wanner C: Misleading terms in Anderson-Fabry disease. Eur J Clin Invest; 2008 Mar;38(3):191-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Signs and symptoms of classic Fabry disease manifest itself on the skin (angiokeratoma), the nervous system (acroparaesthesia), the heart (restrictive cardiomyopathy) and a variety of other organs.
  • MATERIALS AND METHODS: Diagnosis of Fabry disease was confirmed by genetic tests in a cohort of 100 patients and a standardized examination programme was performed in all patients.
  • RESULTS: Among the 47 male and 53 female patients (mean age 41 +/- 16 years) with genetically proven disease, the Fabry-type vascular skin lesions were without hyperkeratotic aspect and keratomas were virtually absent.
  • We propose to replace the term 'angiokeratoma' with 'angioma', the term 'acroparaesthesia' with 'neuropathic pain' and the term 'restrictive cardiomyopathy' with 'cardiac hypertrophic storage disease'.
  • As most of the physicians are not familiar with Fabry disease, terms used in the past might prevent the correct diagnosis of a potentially treatable disease.
  • [MeSH-major] Angiokeratoma / diagnosis. Cardiovascular Diseases / diagnosis. Fabry Disease / diagnosis. Paresthesia / diagnosis
  • [MeSH-minor] Adult. Cohort Studies. Diagnosis, Differential. Echocardiography, Doppler. Female. Humans. Male. Middle Aged. Skin Diseases / pathology. Terminology as Topic


92. Kavak A, Parlak AH, Yesildal N, Aydogan I, Anul H: Preliminary study among truck drivers in Turkey: effects of ultraviolet light on some skin entities. J Dermatol; 2008 Mar;35(3):146-50
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  • [Title] Preliminary study among truck drivers in Turkey: effects of ultraviolet light on some skin entities.
  • In this study, we aimed to compare driver (left) and opposite (right) sides for some skin entities in drivers.
  • We also evaluated the effect of occupational duration, age and skin type among this population.
  • Dermatological entities such as actinic keratosis, solar lentigo, seborrheic keratosis, melanocytic nevus, spider angioma, ephelid, basal cell carcinoma (BCC), squamous cell carcinoma, and melanoma were compared to driver and right sides.
  • (ii) occupational duration (subgroups O1, 1-10 years, and 02, >10 years); and (iii) skin type (subgroups S1, skin types I and II, and S2, skin types III and IV.
  • [MeSH-major] Commerce. Motor Vehicles. Occupational Diseases / pathology. Occupational Exposure / adverse effects. Skin Diseases / pathology. Ultraviolet Rays / adverse effects

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  • (PMID = 18346257.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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93. Rudnick EF, Chen EY, Manning SC, Perkins JA: PHACES syndrome: otolaryngic considerations in recognition and management. Int J Pediatr Otorhinolaryngol; 2009 Feb;73(2):281-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Children with segmental facial hemangiomas of infancy and one extracutaneous manifestation comprising PHACES (posterior fossa malformation, arteriovenous malformations, cardiac/aortic defects, eye anomalies, and sternal defect) were identified.
  • Treatment for cutaneous and airway hemangiomas included oral and intralesional steroids, CO(2) or pulse-dye laser, tracheotomy, and surgical excision.
  • RESULTS: Of 246 children with segmental facial hemangiomas of infancy evaluated since January 2000, 5 girls (2.0%) met diagnostic criteria for PHACES.
  • Otolaryngic abnormalities included middle ear atelectasis (1/5), tympanic membrane hemangiomas with conductive hearing loss (3/5), skin and cartilage ulceration (2/5), dysphagia (4/5), and airway hemangiomas with stridor (3/5).
  • Three children received oral steroids and required pulse-dye laser for cutaneous hemangiomas of infancy.
  • Additional interventions included tympanostomy tubes and resection of nasal hemangioma.
  • CONCLUSIONS: Diagnosis of PHACES requires awareness of the association of facial hemangiomas of infancy with systemic and airway problems.
  • [MeSH-major] Abnormalities, Multiple / diagnosis. Hemangioma / diagnosis. Otorhinolaryngologic Diseases / diagnosis
  • [MeSH-minor] Cardiovascular Abnormalities / diagnosis. Cranial Fossa, Posterior / abnormalities. Facial Neoplasms / diagnosis. Facial Neoplasms / drug therapy. Facial Neoplasms / surgery. Female. Glucocorticoids / therapeutic use. Heart Defects, Congenital / diagnosis. Humans. Infant. Infant, Newborn. Intracranial Arteriovenous Malformations / diagnosis. Laser Therapy. Lip Neoplasms / diagnosis. Lip Neoplasms / surgery. Lip Neoplasms / therapy. Retrospective Studies. Skin Neoplasms / diagnosis. Skin Neoplasms / drug therapy. Skin Neoplasms / surgery. Syndrome. Tracheal Neoplasms / diagnosis. Tracheal Neoplasms / drug therapy. Tracheal Neoplasms / surgery. Tracheotomy

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  • (PMID = 19081148.001).
  • [ISSN] 0165-5876
  • [Journal-full-title] International journal of pediatric otorhinolaryngology
  • [ISO-abbreviation] Int. J. Pediatr. Otorhinolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Glucocorticoids
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94. Browning J, Frieden I, Baselga E, Wagner A, Metry D: Congenital, self-regressing tufted angioma. Arch Dermatol; 2006 Jun;142(6):749-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Congenital, self-regressing tufted angioma.
  • BACKGROUND: Tufted angioma (known in Japanese literature as angioblastoma of Nakagawa) is an uncommon, histologically benign, vascular tumor.
  • OBSERVATIONS: We present a series of 5 histopathologically confirmed cases of congenital tufted angioma that spontaneously regressed during infancy or early childhood.
  • CONCLUSION: We recommend that observation for potential regression be considered for otherwise uncomplicated congenital or early infantile cases of tufted angioma.
  • [MeSH-major] Hemangioma, Capillary / diagnosis. Neoplasm Regression, Spontaneous / pathology. Skin Neoplasms / diagnosis
  • [MeSH-minor] Arm. Cheek. Diagnosis, Differential. Female. Forearm. Forehead. Humans. Infant. Infant, Newborn. Male. Shoulder

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  • (PMID = 16785378.001).
  • [ISSN] 0003-987X
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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95. Pascual-Castroviejo I, Pascual-Pascual SI, Velazquez-Fragua R, García-Guereta L, López-Gutiérrez JC, Olivares P, Tovar J: Association of cutaneous red-to-purple hemangiomas with leptomeningeal hemangiomas. a clinical study of two patients. Neuropediatrics; 2010 Feb;41(1):7-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Association of cutaneous red-to-purple hemangiomas with leptomeningeal hemangiomas. a clinical study of two patients.
  • Cutaneous hemangioma is a benign vascular tumor of infancy with an initial proliferating period that appears between 1 to 2 weeks of life, extends during 18 months to 2 years of life, and then slowly regresses during several years until it disappears completely.
  • Vascular malformations are present at birth, grow commensurately with the child, and are characterized histologically by a normal rate of endothelial cell turnover, flat endothelium, thin (normal) basal membrane and normal mast cells.
  • These cutaneous anomalies are commonly associated with cerebellar malformations, main cerebral arteries anomalies, congenital cardiac anomalies and/or coarctation of the aorta and persistence of embryonic arteries.
  • Cutaneous hemangiomas can be associated with intracranial or extracranial hemangiomas that regress at the same time as the cutaneous hemangiomas.
  • Cutaneous hemangiomas may show different types of color.
  • Cutaneous red-to-purple hemangiomas are uncommon and their bright-red color is evident from the first weeks of life and remains unaltered until the hemangioma disappears.
  • The intracranial angiographic studies in our series of more than 50 cases with facial hemangioma showed that patients with red-to-purple hemangiomas are commonly associated with localized leptomeningeal hemangiomas either in the ipsilateral or contralateral side.
  • These leptomingeal hemangiomas were visualized only by MR enhanced with gadolinium.
  • Involution of the cutaneous and leptomeningeal hemangiomas seems to occur simultaneously as in other types of external and internal hemangiomas.
  • [MeSH-major] Hemangioma. Meningeal Neoplasms. Skin Diseases, Vascular. Skin Neoplasms

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  • (PMID = 20571984.001).
  • [ISSN] 1439-1899
  • [Journal-full-title] Neuropediatrics
  • [ISO-abbreviation] Neuropediatrics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] AU0V1LM3JT / Gadolinium
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96. Garzon MC, Lucky AW, Hawrot A, Frieden IJ: Ultrapotent topical corticosteroid treatment of hemangiomas of infancy. J Am Acad Dermatol; 2005 Feb;52(2):281-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ultrapotent topical corticosteroid treatment of hemangiomas of infancy.
  • BACKGROUND: Superficial cutaneous hemangiomas of infancy represent a therapeutic challenge.
  • Two small case series using ultrapotent topical corticosteroids for periocular hemangiomas were reported in the ophthalmologic literature.
  • The use of this therapy for hemangiomas of infancy at other sites on the body has not been reported.
  • OBJECTIVE: We sought to assess the clinical effects of short-term application of ultrapotent topical corticosteroids for the treatment of hemangiomas of infancy.
  • METHODS: The records of 34 infants with proliferating hemangiomas of infancy that were treated with ultrapotent topical steroids were reviewed retrospectively.
  • CONCLUSIONS: Hemangiomas in 74% of the infants demonstrated either good or partial response to treatment with ultrapotent topical corticosteroids.
  • Improvement varied, with thinner superficial hemangiomas demonstrating better cosmetic improvement than thicker lesions.
  • [MeSH-major] Betamethasone / analogs & derivatives. Clobetasol / analogs & derivatives. Hemangioma / drug therapy. Skin Neoplasms / drug therapy
  • [MeSH-minor] Administration, Cutaneous. Extremities. Eye Neoplasms / drug therapy. Eyelids. Facial Neoplasms / drug therapy. Female. Humans. Infant. Infant, Newborn. Male. Retrospective Studies. Treatment Outcome

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  • (PMID = 15692474.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 826Y60901U / betamethasone-17,21-dipropionate; 9842X06Q6M / Betamethasone; 9P6159HM7T / halobetasol; ADN79D536H / Clobetasol
  • [Number-of-references] 14
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97. Yang JH, Kim JW, Park HS, Jang SJ, Choi JC: Eruptive pseudoangiomatosis. J Dermatol; 2006 Dec;33(12):873-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • It is characterized by an eruption of distinctive erythematous angioma-like papules often surrounded by a pale halo, with histological findings distinct from that of true angiomas.
  • We describe three women with angioma-like papules.
  • [MeSH-major] Angiomatosis / diagnosis. Skin Diseases, Vascular / diagnosis
  • [MeSH-minor] Aged. Biopsy. Capillaries / pathology. Diagnosis, Differential. Endothelial Cells / pathology. Endothelium, Vascular / pathology. Exanthema / diagnosis. Female. Hemangioma / diagnosis. Humans. Lymphocytes / pathology. Middle Aged. Skin Neoplasms / diagnosis

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  • (PMID = 17169093.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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98. Malliah R, Shah V, Heller DS: Umbilical cord hemangioma associated with multiple cutaneous hemangiomas in a newborn. Int J Gynaecol Obstet; 2007 Oct;99(1):58
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Umbilical cord hemangioma associated with multiple cutaneous hemangiomas in a newborn.
  • [MeSH-major] Hemangioma / pathology. Skin Neoplasms / pathology. Umbilical Cord / pathology

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  • (PMID = 17379218.001).
  • [ISSN] 0020-7292
  • [Journal-full-title] International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
  • [ISO-abbreviation] Int J Gynaecol Obstet
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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99. Toldo I, Drigo P, Mammi I, Marini V, Carollo C: Vertebral and spinal cavernous angiomas associated with familial cerebral cavernous malformation. Surg Neurol; 2009 Feb;71(2):167-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Cerebral cavernous malformations are vascular malformations that affect the CNS and have been associated with cutaneous, retinal, and hepatic lesions.
  • Until now, vertebral hemangiomas associated with CCM have been described only in one case.
  • In addition to previous studies, the occurrence of spinal, vertebral, and cutaneous cavernous angiomas is now described in different members of a large family with CCM.
  • CASE DESCRIPTION: Our study reports a previously described family (IFCAS-07) with 12 members affected by autosomal dominant cavernous angiomas: 11 had CCM either alone or associated with hepatic or retinal angiomas, and one had only hepatic angioma.
  • Spinal MRI showed in 5 subjects spinal cavernous angiomas either alone or associated with vertebral hemangiomas.
  • CONCLUSIONS: To our knowledge, this is the largest family reported with different subjects affected by CCM associated with multiple cavernous angiomas throughout (brain and spinal cord) and besides (retina, skin, liver, and vertebral column) the CNS.
  • We emphasize the importance of spinal MRI in the diagnosis of spinal and vertebral cavernous angiomas in all patients affected by familial CCM.
  • [MeSH-major] Central Nervous System Neoplasms / etiology. Central Nervous System Vascular Malformations / complications. Hemangioma, Cavernous / etiology. Spinal Neoplasms / etiology
  • [MeSH-minor] Adult. Cohort Studies. Female. Humans. Male. Microtubule-Associated Proteins / genetics. Middle Aged. Pedigree. Proto-Oncogene Proteins / genetics. Skin Neoplasms / diagnosis. Skin Neoplasms / etiology. Skin Neoplasms / therapy. Young Adult

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  • (PMID = 18207546.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / KRIT1 protein, human; 0 / Microtubule-Associated Proteins; 0 / Proto-Oncogene Proteins
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100. Douri T: Multiple cutaneous hemangiomas accompanied by hepatic hemangiomas. Dermatol Online J; 2005;11(1):21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multiple cutaneous hemangiomas accompanied by hepatic hemangiomas.
  • [MeSH-major] Hemangioma / diagnosis. Liver Neoplasms / diagnosis. Neoplasms, Multiple Primary / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 15748562.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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