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1. Chaddad Neto F, Lopes A, Machado Filho M, Catanoce A, Campos Filho JM, Oliveira Ed: Giant cavernoma of the orbit: clinical and surgical considerations. Arq Neuropsiquiatr; 2007 Dec;65(4A):992-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Cavernous hemangiomas of the orbit are benign, hamartomatous, vascular lesions, more frequent in middle-aged women, representing the most common benign primitive neoplasm of the orbit.
  • We describe the case of a patient with a volumous orbital cavernoma, approached by a fronto-orbito-zigotomy.
  • [MeSH-major] Hemangioma, Cavernous / surgery. Orbital Neoplasms / surgery

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  • (PMID = 18094861.001).
  • [ISSN] 0004-282X
  • [Journal-full-title] Arquivos de neuro-psiquiatria
  • [ISO-abbreviation] Arq Neuropsiquiatr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Brazil
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2. Wiygul JB, Palmer L: Isolated hemangioma causing gross painless hematuria in an adolescent male. Urology; 2010 Aug;76(2):463-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Isolated hemangioma causing gross painless hematuria in an adolescent male.
  • Hematuria in children is usually a benign entity, with hypercalciuria being the usual etiology; however, rarer causes also exist, including genitourinary hemangioma.
  • Hemangioma is a benign tumor, which has a tendency to regress spontaneously by the second year of life.
  • However, there are reports of isolated bladder hemangioma in the pediatric population causing isolated gross hematuria.
  • We report a case of bladder hemangioma causing gross painless hematuria in an otherwise healthy 14-year-old boy.
  • [MeSH-major] Hemangioma / complications. Hematuria / etiology. Urinary Bladder Neoplasms / complications

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20163837.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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3. Willenberg T, Baumgartner I: Vascular birthmarks. Vasa; 2008 Feb;37(1):5-17
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Vascular birthmarks can be classified into hemangioma and vascular malformations.
  • Hemangioma are frequent tumours of early infancy demonstrating endothelial hyperplasia, a history of rapid neonatal growth and slow involution during later childhood.
  • Treatment of hemangioma is dependent of stage and type of the lesion.
  • Given the current availability of drugs, lasers, and other techniques to treat hemangioma safely, philosophy of "benign neglect" should not be considered anymore.
  • Exact diagnosis by employing modern diagnostic means,which are able to differentiate low-flow from high flow lesions is important for further therapeutic management.
  • [MeSH-major] Hemangioma. Lymphatic Abnormalities. Skin Abnormalities. Vascular Malformations

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  • (PMID = 18512538.001).
  • [ISSN] 0301-1526
  • [Journal-full-title] VASA. Zeitschrift für Gefässkrankheiten
  • [ISO-abbreviation] VASA
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 56
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4. Cham E, Smoller BR, Lorber DA, Victor TA, Cibull TL: Epithelioid hemangioma (angiolymphoid hyperplasia with eosinophilia) arising on the extremities. J Cutan Pathol; 2010 Oct;37(10):1045-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epithelioid hemangioma (angiolymphoid hyperplasia with eosinophilia) arising on the extremities.
  • BACKGROUND: Epithelioid hemangioma (EH) is a benign vascular proliferation usually accompanied by a mixed inflammatory infiltrate.
  • Awareness that the presence of CD30+ activated lymphocytes is not specific for lymphoma and recognition of the vascular component is critical for proper diagnosis of EH.
  • [MeSH-minor] Adult. Aged. Antigens, CD30 / metabolism. Diagnosis, Differential. Humans. Immunohistochemistry. Lymphoproliferative Disorders / pathology. Middle Aged

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  • (PMID = 19702686.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD30
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5. Petit P: [Imaging in diagnosis and treatment of vascular lesions of the hand]. Chir Main; 2008 Dec;27 Suppl 1:S201-10
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  • [Title] [Imaging in diagnosis and treatment of vascular lesions of the hand].
  • [Transliterated title] Approche diagnostique et thérapeutique en imagerie des anomalies vasculaires de la main.
  • Vascular lesions of the hand are challenging for diagnosis and treatment.
  • It allows to separate the high flow lesions (hemangioma, arteriovenous malformation) from the low or no flow lesions (venous malformation, cystic lymphangioma).
  • Hemangioma is a benign tumor which most often spontaneously involutes with age.
  • [MeSH-major] Hand / blood supply. Hemangioma. Vascular Malformations
  • [MeSH-minor] Arteriovenous Malformations / diagnosis. Arteriovenous Malformations / surgery. Arteriovenous Malformations / therapy. Diagnosis, Differential. Embolization, Therapeutic. Humans. Lymphangioma, Cystic / diagnosis. Lymphangioma, Cystic / surgery. Lymphangioma, Cystic / therapy. Magnetic Resonance Imaging. Radiology, Interventional. Treatment Outcome. Ultrasonography, Doppler

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  • (PMID = 18842442.001).
  • [ISSN] 1297-3203
  • [Journal-full-title] Chirurgie de la main
  • [ISO-abbreviation] Chir Main
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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6. Petsas T, Tsamandas A, Tsota I, Karavias D, Karatza C, Vassiliou V, Kardamakis D: A case of hepatocellular carcinoma arising within large focal nodular hyperplasia with review of the literature. World J Gastroenterol; 2006 Oct 28;12(40):6567-71
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  • Focal nodular hyperplasia (FNH) is a relatively rare benign hepatic tumor, usually presenting as a solitary lesion; however, multiple localizations have also been described.
  • The association of FNH with other hepatic lesions, such as adenomas and haemangiomas has been reported by various authors.
  • We herein report a case of a hepatocellular carcinoma arising within a large focal nodular hyperplasia, in a young female patient.
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans

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  • (PMID = 17072995.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 33
  • [Other-IDs] NLM/ PMC4100652
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7. Schwartz GD, Barkin JS: Small-bowel tumors detected by wireless capsule endoscopy. Dig Dis Sci; 2007 Apr;52(4):1026-30
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  • Malignant tumors comprised 61% (54/89) and benign 39% (35/89).
  • The most common benign tumors were GIST, hemangiomas, hamartomas, adenomas, and granulation tissue polyps.
  • [MeSH-major] Capsule Endoscopy. Endoscopy, Gastrointestinal. Intestinal Neoplasms / diagnosis. Intestine, Small

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  • (PMID = 17380403.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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8. Quaia E, Alaimo V, Baratella E, Pizzolato R, Cester G, Medeot A, Cova MA: Effect of observer experience in the differentiation between benign and malignant liver tumors after ultrasound contrast agent injection. J Ultrasound Med; 2010 Jan;29(1):25-36
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effect of observer experience in the differentiation between benign and malignant liver tumors after ultrasound contrast agent injection.
  • OBJECTIVE: The purpose of this study was to assess the impact of the observer level of experience on the diagnostic performance of contrast-enhanced ultrasound imaging (CEUS) for differentiation between benign and malignant liver tumors.
  • METHODS: From a computerized search, we retrospectively identified 286 biopsy-proven liver tumors (105 hepatocellular carcinomas, 48 metastases, 7 intra-hepatic cholangiocarcinomas, 33 liver hemangiomas, and 93 nonhemangiomatous benign lesions) in 235 patients (140 male and 95 female; mean age +/- SD, 56 +/- 11 years) who underwent CEUS after sulfur hexafluoride-filled microbubble injection.
  • Each observer used a 5-point scale to grade diagnostic confidence: 1, definitely benign; 2, probably benign; 3, indeterminate; 4, probably malignant; or 5, definitely malignant on the basis of the enhancement pattern during the arterial phase and enhancement degree during the portal and late phases compared with the liver (hypoenhancement indicating malignant and isoenhancement to hyperenhancement indicating benign).
  • The experienced observers showed higher diagnostic performance in malignancy diagnosis than did inexperienced observers (overall accuracy: group 1, 63.3%-72.8%; group 2, 75.9%-93.1%; P < .05, chi(2) test).

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  • (PMID = 20040772.001).
  • [ISSN] 1550-9613
  • [Journal-full-title] Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
  • [ISO-abbreviation] J Ultrasound Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Phospholipids; 0 / contrast agent BR1; WS7LR3I1D6 / Sulfur Hexafluoride
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9. Williams DS: Cardiac hemangioma. J Insur Med; 2007;39(2):135-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cardiac hemangioma.
  • Cardiac hemangiomas are benign vascular tumors that can affect patients of any age.
  • [MeSH-major] Heart Diseases / diagnosis. Hemangioma / diagnosis

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  • (PMID = 17941339.001).
  • [ISSN] 0743-6661
  • [Journal-full-title] Journal of insurance medicine (New York, N.Y.)
  • [ISO-abbreviation] J Insur Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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10. Coenegrachts K, Ghekiere J, Denolin V, Gabriele B, Hérigault G, Haspeslagh M, Daled P, Bipat S, Stoker J, Rigauts H: Perfusion maps of the whole liver based on high temporal and spatial resolution contrast-enhanced MRI (4D THRIVE): feasibility and initial results in focal liver lesions. Eur J Radiol; 2010 Jun;74(3):529-35
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: In total 29 LMs, 17 hemangiomas and 4 focal nodular hyperplasias were evaluated.
  • FLLs could be differentiated by qualitative assessment of parametric maps respectively three-phased contrast-enhanced MRI (Fisher's p<0.001 for comparisons between LMs and hemangiomas and LMs and FNHs for both ring-enhancement and lesion heterogeneity) rather than by quantitative analysis of parametric maps (Chi-square for Kep=0.33 (p=0.847) and Chi-square for Kel=1.35 (p=0.509)).
  • Qualitative rather than quantitative analysis was accurate for differentiating malignant and benign FLLs.

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  • [Copyright] Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 19375256.001).
  • [ISSN] 1872-7727
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
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11. Völk M, Strotzer M: [Diagnostic imaging of splenic disease]. Radiologe; 2006 Mar;46(3):229-43; quiz 244
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Diagnostic imaging of splenic disease].
  • Primary diseases of the spleen are relatively rare.
  • More frequently, the spleen is involved secondarily in hematological, oncological, infectious, immunological, vascular, and other systemic diseases.
  • The most frequent primary and secondary diseases of the spleen, including rare diagnoses, are presented and illustrated.
  • Hemangioma represents the most common primary benign tumor, and lymphoma the most common primary malignant tumor of the spleen.
  • Diagnostic imaging does not a allow safe differentiation between Hodgkin's and non-Hodgkin's lymphoma.
  • One section deals with the clinical value and diagnostic workup of incidentally detected lesions.
  • Additional clarification using CT or MRT should be reserved for cases with a strong suspicion of clinically relevant primary or secondary splenic disease.
  • [MeSH-major] Diagnostic Imaging / methods. Image Enhancement / methods. Spleen / diagnostic imaging. Spleen / pathology. Splenic Diseases / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Humans. Practice Guidelines as Topic. Radiography

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  • (PMID = 16435091.001).
  • [ISSN] 0033-832X
  • [Journal-full-title] Der Radiologe
  • [ISO-abbreviation] Radiologe
  • [Language] ger
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 24
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12. Lehotska V: Soft-tissue tumors--role of diagnostic imaging. Bratisl Lek Listy; 2005;106(6-7):236-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • However, diagnosis remained problematic, with images sufficiently suggesting the correct histology in only a minority of cases: typically, lipomas and hemangiomas.
  • Attempts were made to develop rules analogous to those for bone tumors, for differentiating benign and malignant processes on the basis of lesion morphology and signal intensity.
  • [MeSH-major] Soft Tissue Neoplasms / diagnosis

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  • (PMID = 16201745.001).
  • [ISSN] 0006-9248
  • [Journal-full-title] Bratislavské lekárske listy
  • [ISO-abbreviation] Bratisl Lek Listy
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Slovakia
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13. Maestroni U, Dinale F, Frattini A, Cortellini P: Ureteral hemangioma: a clinical case report. Acta Biomed; 2005 Sep;76(2):115-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ureteral hemangioma: a clinical case report.
  • Of the tumors benign ureteral, the emangioma is a very rare vascular neoplasm.
  • [MeSH-major] Hemangioma. Ureteral Neoplasms

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  • (PMID = 16350557.001).
  • [ISSN] 0392-4203
  • [Journal-full-title] Acta bio-medica : Atenei Parmensis
  • [ISO-abbreviation] Acta Biomed
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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14. Jiménez-Hernández E, Dueñas-González MT, Quintero-Curiel JL, Velásquez-Ortega J, Magaña-Pérez JA, Berges-García A, Arellano-Galindo J: Treatment with interferon-alpha-2b in children with life-threatening hemangiomas. Dermatol Surg; 2008 May;34(5):640-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Treatment with interferon-alpha-2b in children with life-threatening hemangiomas.
  • BACKGROUND: Childhood hemangiomas are benign tumors of endothelial cells, characterized by a rapidly proliferating initial phase and followed by a slow involution.
  • OBJECTIVE: The objective was to determine the therapeutic effectiveness of interferon (IFN)-alpha-2b in children with hemangiomas threatening the patient's functions or life.
  • RESULTS The study included 20 patients with hemangiomas localized in different sites and with diverse functional alterations: ages varied between 3 and 48 months (median, 12.8 months), and 8 were male and 12 female.
  • CONCLUSIONS: We can conclude that IFN-alpha-2b is an effective option for treating alarming hemangiomas that are resistant to steroids and that endanger proper functioning of the affected organ or the patient's life.
  • [MeSH-major] Angiogenesis Inhibitors / therapeutic use. Hemangioma / drug therapy. Interferon-alpha / therapeutic use

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  • (PMID = 18261103.001).
  • [ISSN] 1524-4725
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Interferon-alpha; 0 / Recombinant Proteins; 99210-65-8 / interferon alfa-2b
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15. Papadopouli E, Michailidi E, Papadopoulou E, Paspalaki P, Vlahakis I, Kalmanti M: Cervical lymphadenopathy in childhood epidemiology and management. Pediatr Hematol Oncol; 2009 Sep;26(6):454-60
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  • Biopsies revealed 4 thyroglossal cysts, 3 branchial cysts, 1 hemangioma, 2 sebaceous cysts, 1 dermoid cyst, 5 occurrences of tuberculosis lymphadenitis, 1 occurrence of Bartonella henselae lymphadenopathy, and 1 case of non-Hodgkin lymphoma.
  • In conclusion, CL is usually a benign finding; bacterial and viral infections are the most common causes.
  • [MeSH-major] Lymphatic Diseases / epidemiology. Lymphatic Diseases / therapy

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  • (PMID = 19657996.001).
  • [ISSN] 1521-0669
  • [Journal-full-title] Pediatric hematology and oncology
  • [ISO-abbreviation] Pediatr Hematol Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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16. Sangüeza OP, Walsh SN, Sheehan DJ, Orland AF, Llombart B, Requena L: Cutaneous epithelioid angiomatous nodule: a case series and proposed classification. Am J Dermatopathol; 2008 Feb;30(1):16-20
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  • [Title] Cutaneous epithelioid angiomatous nodule: a case series and proposed classification.
  • All the cases reported thus far have followed a benign course.
  • We also discuss the histological differential diagnoses with other epithelioid proliferations and propose categorization within the spectrum of epithelioid hemangioma.
  • [MeSH-minor] Adolescent. Adult. Aged. Diagnosis, Differential. Female. Hemangioendothelioma / pathology. Hemangioendothelioma, Epithelioid / pathology. Humans. Male. Middle Aged. Retrospective Studies. Skin / blood supply. Skin / pathology

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  • [CommentIn] Am J Dermatopathol. 2008 Jun;30(3):302-4 [18496440.001]
  • (PMID = 18212538.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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17. Schwedt TJ, Guo Y, Rothner AD: "Benign" imaging abnormalities in children and adolescents with headache. Headache; 2006 Mar;46(3):387-98
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  • [Title] "Benign" imaging abnormalities in children and adolescents with headache.
  • OBJECTIVE: To study the frequency of "benign" abnormalities on brain imaging in children with headache, compare it with the frequency of imaging findings that dictate a change in patient management, and determine the association of benign findings with headache.
  • Patients with benign imaging abnormalities were compared to those with nonbenign findings.
  • Benign abnormalities were defined as those that did not result in a change in patient management.
  • Using literature review, we discuss the benign findings and their possible association with headache.
  • Forty-six (19.1%) were found to have 50 benign abnormalities including 13 sinus disease, 11 Chiari I malformations, 7 nonspecific white matter abnormalities, 5 venous angiomas, 5 arachnoid cysts, 4 enlarged Virchow-Robin spaces, 2 pineal cysts, 1 mega cisterna magna, 1 fenestration of the proximal basilar artery, and 1 periventricular leukomalacia.
  • These included 5 sinus disease, 4 tumors, 4 old infarcts, 3 Chiari I, 2 moyamoya, 1 intracranial vascular stenosis, 1 internal jugular vein occlusion, 1 arteriovenous malformation, 1 demyelinating disease, and 1 intracerebral hemorrhage.
  • CONCLUSIONS: Approximately 20% of pediatric headache patients with brain imaging have benign abnormalities that do not result in a change in headache management.
  • [MeSH-major] Headache / diagnosis
  • [MeSH-minor] Adolescent. Arnold-Chiari Malformation / complications. Arnold-Chiari Malformation / diagnosis. Brain Diseases / complications. Brain Diseases / diagnosis. Child. Child, Preschool. Female. Humans. Magnetic Resonance Imaging. Male. Paranasal Sinus Diseases / complications. Paranasal Sinus Diseases / diagnosis. Tomography, X-Ray Computed

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  • (PMID = 16618255.001).
  • [ISSN] 0017-8748
  • [Journal-full-title] Headache
  • [ISO-abbreviation] Headache
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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18. Tresoldi S, Sardanelli F, Borzani I, Flor N, Cornalba G: Liver metastases on serial contrast-enhanced multidetector computed tomography examinations: was the detection possible on previous examinations? J Comput Assist Tomogr; 2006 May-Jun;30(3):378-85
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  • When metastases had been reported, an evaluation of the preceding MDCT was done to define whether the lesion was detectable, detectable only by minimal signs, undetectable, or detected but misdiagnosed as a benign lesion (MBL).
  • The MBL was a non-Hodgkin lesion first misdiagnosed as a hemangioma.
  • CONCLUSION: Approximately 15% of liver metastases were prospectively missed, 9% of them being retrospectively detectable, 6% being retrospectively visible as minimal signs, whereas only 1% of liver metastases were misdiagnosed as a benign lesion.

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  • (PMID = 16778610.001).
  • [ISSN] 0363-8715
  • [Journal-full-title] Journal of computer assisted tomography
  • [ISO-abbreviation] J Comput Assist Tomogr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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19. Floris G, Deraedt K, Samson I, Brys P, Sciot R: Epithelioid hemangioma of bone: a potentially metastasizing tumor? Int J Surg Pathol; 2006 Jan;14(1):9-15; discussion 16-20
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  • [Title] Epithelioid hemangioma of bone: a potentially metastasizing tumor?
  • The case of a 15-year-old boy with a severe swelling of the 2nd toe in the left foot and a large swelling of the left inguinofemoral region is described.
  • Histologic examination of the foot lesion showed a typical epithelioid hemangioma of bone that extended into the soft tissues, with a secondary location in the groin, suggestive of lymph node involvement.
  • Besides the fact that epithelioid hemangioma of the toe has not been reported yet, our case showed a non-continuous localization, most likely in draining lymph nodes.
  • This finding suggests metastatic disease, an event that is extremely rare for epithelioid hemangioma.
  • As such, epithelioid hemangioma might be comparable to another benign vascular tumor, the retiform hemangioendothelioma, which occasionally metastasizes to the lymph nodes without systemic spread.
  • [MeSH-major] Angiolymphoid Hyperplasia with Eosinophilia / pathology. Bone Diseases / pathology. Hemangioendothelioma, Epithelioid / pathology. Lymph Nodes / pathology. Lymphatic Metastasis. Toe Phalanges / pathology
  • [MeSH-minor] Adolescent. Antigens, CD31 / analysis. Antigens, CD34 / analysis. Diagnosis, Differential. Groin. Humans. Immunohistochemistry. Keratins / analysis. Male. Radiography

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  • [Copyright] Int J Surg Pathol 14(1):9-15, 2006.
  • (PMID = 16501828.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Antigens, CD34; 68238-35-7 / Keratins
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20. Serra AM, Soares FM, Cunha Júnior AG, Costa IM: Therapeutic management of skin hemangiomas in children. An Bras Dermatol; 2010 May-Jun;85(3):307-17
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  • [Title] Therapeutic management of skin hemangiomas in children.
  • BACKGROUND: Hemangiomas are benign, self-involuting tumors of endothelial cells that are common in childhood.
  • OBJECTIVES: To evaluate the treatment of 122 patients with skin hemangiomas treated at a teaching hospital in Brasilia, Brazil between March 2000 and December 2006.
  • In 42 patients, hemangiomas were superficial, while in 13 cases they were deep and in 67 patients lesions were mixed.
  • In 79 patients, hemangiomas were in the cephalic region.
  • CONCLUSIONS: The data obtained in this study were in agreement with results in the literature with respect to gender and the site of the lesions.
  • The incidence of hemangiomas present at birth was higher than rates published in the literature.
  • Identification of hemangiomas that require treatment, as well as the right moment for intervention and the best therapeutic option for each case, are factors that need to be taken into consideration.
  • [MeSH-major] Hemangioma / therapy. Skin Neoplasms / therapy

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  • (PMID = 20676463.001).
  • [ISSN] 1806-4841
  • [Journal-full-title] Anais brasileiros de dermatologia
  • [ISO-abbreviation] An Bras Dermatol
  • [Language] eng; por
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
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21. Rana N, Ming Z, Hui MS, Bin Y: Case Report: Littoral cell angioma of spleen. Indian J Radiol Imaging; 2009 Jul-Sep;19(3):210-2
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  • [Title] Case Report: Littoral cell angioma of spleen.
  • Littoral cell angioma is a rare primary vascular neoplasm of the spleen, composed of littoral cells that line the splenic sinuses of the red pulp.
  • It was thought to be a benign, incidental lesion.
  • The definitive diagnosis can only be made after histology and immunohistochemistry studies.

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  • (PMID = 19881088.001).
  • [ISSN] 1998-3808
  • [Journal-full-title] The Indian journal of radiology & imaging
  • [ISO-abbreviation] Indian J Radiol Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2766879
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22. Borse R, Mahapatra GN, Meht R, Plumber S, Dhuri S, Ali S: Scintigraphic finding of a silent hepatic haemangioma. J Assoc Physicians India; 2010 Oct;58:637-40
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  • [Title] Scintigraphic finding of a silent hepatic haemangioma.
  • Hepatic haemangioma is the most common benign tumour of liver.
  • Tc 99m RBC blood pool imaging is highly specific diagnostic modality of choice for hepatic haemangioma as its hypervascular nature may create equivocal result on CT or MRI.
  • Therefore all patients suspected of having hepatic haemangioma should undergo Tc 99m blood pool imaging.
  • [MeSH-major] Erythrocytes / radionuclide imaging. Hemangioma / radionuclide imaging. Liver Neoplasms / radionuclide imaging

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  • (PMID = 21510118.001).
  • [ISSN] 0004-5772
  • [Journal-full-title] The Journal of the Association of Physicians of India
  • [ISO-abbreviation] J Assoc Physicians India
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 7440-26-8 / Technetium
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23. Alexiou GA, Mpairamidis E, Sfakianos G, Prodromou N: Surgical management of brain cavernomas in children. Pediatr Neurosurg; 2009;45(5):375-8
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  • BACKGROUND: Cavernous hemangiomas are benign vascular hamartomas caused by developmental malformations of the vascular bed.
  • The parietal lobe was the most common site of occurrence, whereas only 2 cavernomas were infratentorial.
  • [MeSH-major] Brain Neoplasms / mortality. Brain Neoplasms / surgery. Hemangioma, Cavernous, Central Nervous System / mortality. Hemangioma, Cavernous, Central Nervous System / surgery. Neurosurgical Procedures

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  • [Copyright] Copyright 2009 S. Karger AG, Basel.
  • (PMID = 19940535.001).
  • [ISSN] 1423-0305
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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24. Phung TL, Hochman M, Mihm MC: Current knowledge of the pathogenesis of infantile hemangiomas. Arch Facial Plast Surg; 2005 Sep-Oct;7(5):319-21
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  • [Title] Current knowledge of the pathogenesis of infantile hemangiomas.
  • Infantile hemangiomas are the most common benign tumor of infancy, occurring shortly after birth in 5% to 10% of white infants.
  • Hemangiomas occur in infants of all races but are most common in those who are white.
  • Many hemangiomas are discrete, well-circumscribed masses present in the head and neck.
  • Some hemangiomas are segmental and diffuse, often involving large areas of the extremities or the head and neck.
  • Chorionic villus sampling at 9 to 12 weeks of gestation has been associated with a 21% increased incidence of hemangiomas in infants.
  • Most hemangiomas occur sporadically without a hereditary component.
  • However, in a few families, hemangiomas segregate as a highly penetrant, autosomal dominant trait.
  • Gene linkage studies of familial infantile hemangiomas show evidence of linkage to chromosome 5q31-33.
  • [MeSH-major] Genetic Predisposition to Disease. Hemangioma / epidemiology. Hemangioma / genetics. Skin Neoplasms / epidemiology. Skin Neoplasms / genetics

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  • (PMID = 16172341.001).
  • [ISSN] 1521-2491
  • [Journal-full-title] Archives of facial plastic surgery
  • [ISO-abbreviation] Arch Facial Plast Surg
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / T32 HL07893
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review
  • [Publication-country] United States
  • [Number-of-references] 32
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25. Salomäki HH, Sainio AO, Söderström M, Pakkanen S, Laine J, Järveläinen HT: Differential expression of decorin by human malignant and benign vascular tumors. J Histochem Cytochem; 2008 Jul;56(7):639-46
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  • [Title] Differential expression of decorin by human malignant and benign vascular tumors.
  • Given that angiogenesis is a sine qua non for tumor growth and progression, we attempted to examine whether human malignant vascular tumors differ from human benign vascular tumors in terms of their decorin expression and synthesis.
  • CD31 immunostaining demonstrated that the human malignant vascular tumors Kaposi's sarcoma and angiosarcoma were filled with capillary-like structures, whereas in benign cavernous and capillary hemangiomas, blood vessels were not as abundantly present.
  • In contrast to sarcomas, in hemangiomas, decorin mRNA expression and immunoreactivity were observed also within the tumor mass, particularly in the connective tissue stroma surrounding the clusters of intratumoral blood vessels.
  • In sarcomas, angiogenesis is extremely powerful, whereas in hemangiomas, angiogenesis has ceased.
  • Decorin certainly provides a usable biomarker for distinguishing between benign and malignant vascular tumors in patients.
  • [MeSH-major] Extracellular Matrix Proteins / biosynthesis. Hemangioma, Capillary / metabolism. Hemangioma, Cavernous / metabolism. Hemangiosarcoma / metabolism. Proteoglycans / biosynthesis. Sarcoma, Kaposi / metabolism. Skin Neoplasms / metabolism

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  • (PMID = 18413650.001).
  • [ISSN] 0022-1554
  • [Journal-full-title] The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
  • [ISO-abbreviation] J. Histochem. Cytochem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Collagen Type I; 0 / DCN protein, human; 0 / Decorin; 0 / Extracellular Matrix Proteins; 0 / Proteoglycans; 0 / RNA, Messenger; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
  • [Other-IDs] NLM/ PMC2430166
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26. Rungsinaporn K, Phaisakamas T: Frequency of abnormalities detected by upper abdominal ultrasound. J Med Assoc Thai; 2008 Jul;91(7):1072-5
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  • Fatty liver, being the most common positive finding, was observed in 1,219 patients (35.9%); 831 of which were men (68.2%) and 388 were women (31.8%).
  • The finding of a liver mass, as the second positive finding, was observed in 209 patients (6.2%); of which were 124 patients (59.3%) with hepatic cyst, 51 patients (24.4%) with hemangioma, 16 patients (7.7%) with indetermined nodule, 11 patients (5.3%) with calcification, and 7 patients (3.4%) with malignant tumor while 664 patients (19.5%) had other positive findings.
  • The most common finding was fatty liver (35.87%).
  • Although the majority of positive findings were benign conditions, some of them might have an adverse effect to the health condition of patients in the long run.
  • The ultrasound findings also yielded the patient management to prevent subsequent disease and to perform medical treatment or follow up.
  • [MeSH-minor] Abdominal Injuries / epidemiology. Abdominal Injuries / pathology. Abdominal Injuries / ultrasonography. Digestive System Diseases / pathology. Digestive System Diseases / ultrasonography. Female. Humans. Male. Prevalence. Thailand / epidemiology

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  • (PMID = 18839847.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Thailand
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27. Rong BG, Chen WL, Ding YP, Xie G, Chen Y, Wang TD: [Surgical approaches to the skull base neoplasms]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2005 Apr;40(4):291-4
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  • In 29 patients with benign tumor including 11 cases of meningioma, 3 cases of chondroma, 1 case of hemangio-meningioma, 1 case of cavernous hemangioma, 2 cases of osteodysplasia fibromas, 9 cases of neurofibroma, 1 case of glomus jugular tumor, 1 case of neurilemmoma, 19 have survived over 5 years and the longest one has survived over 8 years.

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  • (PMID = 16008265.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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28. Sperandeo M, Sperandeo G, Varriale A, Filabozzi P, Decuzzi M, Dimitri L, Vendemiale G: Contrast-enhanced ultrasound (CEUS) for the study of peripheral lung lesions: a preliminary study. Ultrasound Med Biol; 2006 Oct;32(10):1467-72
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  • All FNBs performed under CEUS guidance were adequate for pathologic diagnosis.
  • The other 20 lesions were benign (four lipomas, two fibrous lung tumor, two noncaseous granulomas, six abscesses, one rheumatoid nodule, one histiocytosis X, one chondroid hamartoma, one sclerosing hemangioma, two sarcoid nodules) and none presented intralesional enhancement.

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  • (PMID = 17045865.001).
  • [ISSN] 0301-5629
  • [Journal-full-title] Ultrasound in medicine & biology
  • [ISO-abbreviation] Ultrasound Med Biol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Phospholipids; 0 / contrast agent BR1; WS7LR3I1D6 / Sulfur Hexafluoride
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29. Jang HJ, Kim TK, Wilson SR: Small nodules (1-2 cm) in liver cirrhosis: characterization with contrast-enhanced ultrasound. Eur J Radiol; 2009 Dec;72(3):418-24
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  • Based only on arterial phase (<45 s) vascular intensity and pattern, lesions were prospectively diagnosed as HCC if there was hypervascularity without known features of hemangioma.
  • The diagnosis of HCC was made regardless of the presence or absence of washout.
  • Verification of diagnosis was made by liver transplantation (n=13), biopsy (n=12), resection (n=3) or clinical and imaging follow-up for at least 12 months (n=31).
  • RESULTS: At of the time of CEUS, the 59 nodules were diagnosed as HCC in 26 and benign lesions in 33, including 20 regenerative/dysplastic nodules (RN/DN), 11 hemangiomas, and 2 focal fat sparing.
  • All 26 nodules with arterial phase hypervascularity without hemangioma-like features were HCC.
  • CEUS correctly diagnosed all 11 hemangiomas.
  • CONCLUSIONS: Arterial phase vascular intensity and pattern of CEUS are highly accurate for the diagnosis of small (1-2 cm) HCC and hemangioma in liver cirrhosis.
  • On CEUS, arterial phase hypervascularity without a hemangioma-pattern alone may be sufficient for diagnosis of small HCC.

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  • (PMID = 18834687.001).
  • [ISSN] 1872-7727
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Definity; 0 / Fluorocarbons
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30. Park SM, Shin SM, Seo HE, Kim SH, Kim HS, Park JH, Kim JH, Sohn KR: [A case of sclerosed hemangioma mimicking intrahepatic cholangiocarcinoma]. Korean J Gastroenterol; 2009 Dec;54(6):399-403
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  • [Title] [A case of sclerosed hemangioma mimicking intrahepatic cholangiocarcinoma].
  • Hemangioma is one of the most frequently encountered benign hepatic neoplasm which can develop secondary degeneration.
  • Sclerosed hemangioma is a rare disease histologically characterized by large amount of collagen and elastic fibril between sclerosed small vessels.
  • Its differential diagnosis is very difficult.
  • It should be included in the differential diagnosis of other hepatic lesions such as hepatocellular carcinoma, intrahepatic cholangiocarcinoma, and metastatic hepatic tumor.
  • We describe one case of sclerosed hemangioma mimicking cholangiocarcinoma.
  • [MeSH-major] Hemangioma / diagnosis. Liver Neoplasms / diagnosis
  • [MeSH-minor] Aged. Bile Duct Neoplasms / diagnosis. Bile Ducts, Intrahepatic. Cholangiocarcinoma / diagnosis. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male. Tomography, X-Ray Computed. Ultrasonography


31. Schöniger S, Tivers MS, Baines SJ, Summers BA: Arteriovenous haemangioma in two dogs and a cat. J Comp Pathol; 2008 Aug-Oct;139(2-3):130-6
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  • [Title] Arteriovenous haemangioma in two dogs and a cat.
  • Haemangiomas are benign vascular tumours and several types can be distinguished based on microscopical features.
  • Capillary and cavernous haemangiomas are most commonly reported in man and domestic animals.
  • Arteriovenous haemangiomas are rare variants in man and herein we describe this subtype in two dogs and one cat.
  • Surgically excised masses comprised non-encapsulated proliferations of variably sized arterial- and venous-like vessels, accompanied by clusters of capillaries and immature vascular structures in the feline cutaneous tumour and the canine lingual neoplasm.
  • [MeSH-major] Cat Diseases / pathology. Dog Diseases / pathology. Hemangioma / veterinary. Skin Neoplasms / veterinary. Tongue Neoplasms / veterinary

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  • (PMID = 18620702.001).
  • [ISSN] 0021-9975
  • [Journal-full-title] Journal of comparative pathology
  • [ISO-abbreviation] J. Comp. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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32. Valentini V, Nicolai G, Lorè B, Aboh IV: Intraosseous hemangiomas. J Craniofac Surg; 2008 Nov;19(6):1459-64
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  • [Title] Intraosseous hemangiomas.
  • Intraosseous hemangiomas are classified as benign tumors of vascular nature.
  • In the Maxillo-Facial Surgery departments of the Universities of Rome "La Sapienza" and "Tor Vergata," from 1990 to 2004, 11 cases of intraosseous hemangioma have been diagnosed.
  • In 6 cases, the neoplasm localized in the zygomatic region; in 3 cases, at the mandible level; in 1 patient, in the maxillary site; and in 1 patient, in the frontal bone.
  • Literature review and the case of a male patient affected by left orbitozygomatic hemangioma are described.
  • [MeSH-major] Hemangioma / diagnosis. Orbital Neoplasms / diagnosis. Skull Neoplasms / diagnosis. Zygoma / pathology

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  • (PMID = 19098533.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 22
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33. Trillaud H, Bruel JM, Valette PJ, Vilgrain V, Schmutz G, Oyen R, Jakubowski W, Danes J, Valek V, Greis C: Characterization of focal liver lesions with SonoVue-enhanced sonography: international multicenter-study in comparison to CT and MRI. World J Gastroenterol; 2009 Aug 14;15(30):3748-56
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Characterization of focal liver lesions with SonoVue-enhanced sonography: international multicenter-study in comparison to CT and MRI.
  • The lesions were classified as malignant, benign or indeterminate and the type of lesion was determined.
  • The final diagnosis based on the combined information of all imaging examinations, clinical information and histology (n = 32) was used.
  • RESULTS: In comparison with unenhanced US, SonoVue markedly improves sensitivity and specificity for the characterization (malignant/benign) of focal liver lesions.
  • The sensitivity and specificity of CEUS for the identification of focal nodular hyperplasia (FNH) and hemangiomas was 100% and 87%, resulting in an accuracy of 94.5%.
  • [MeSH-major] Focal Nodular Hyperplasia. Hemangioma. Liver. Liver Neoplasms. Magnetic Resonance Imaging. Tomography, X-Ray Computed. Ultrasonography


34. Kondi-Pafitis A, Kairi-Vassilatou E, Grapsa D, Kalkounou I, Vassilikostas G, Psichogios I: A large benign vascular neoplasm of the male breast. A case report and review of the literature. Eur J Gynaecol Oncol; 2005;26(4):454-6
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  • [Title] A large benign vascular neoplasm of the male breast. A case report and review of the literature.
  • Breast hemangiomas are extremely rare neoplasms in the male population.
  • We report a case of a 77-year old man with a breast hemangioma which was detected in physical examination as a small nodule ten years after a chest injury.
  • The final histological diagnosis was hemangioma of the breast, 6 cm in the largest diameter.
  • To our knowledge, this is the largest benign vascular breast neoplasm in a male patient reported up to date.
  • The rarity of the lesion and its differential diagnosis from angiosarcoma are discussed while the problems encountered in the correct diagnosis and classification of this tumor are also presented.
  • [MeSH-major] Breast Neoplasms, Male / diagnosis. Hemangioma / diagnosis

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  • [CommentIn] Eur J Gynaecol Oncol. 2005;26(6):667; author reply 667-8 [16398236.001]
  • (PMID = 16122203.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 10
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35. Colović R, Suvajdzić N, Grubor N, Colović N, Terzić T: Atypical immunophenotype in a littoral cell angioma. Vojnosanit Pregl; 2009 Jan;66(1):63-5
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  • [Title] Atypical immunophenotype in a littoral cell angioma.
  • BACKGROUND: Littoral-cell angioma (LCA) is a recently described benign vascular tumor of the spleen, whose imaging and pathologic characteristics have been discussed only by a few authors.
  • CASE REPORT: We reported a 60-year-old male with moderate nodular splenomegaly with one large hypoechogenic solid lesion and mild thrombocytopenia in whom the diagnosis of LCA was made after the elective splenectomy.
  • Namely, histopathological and immunohistochemical data allowed a final diagnosis of classical LCA in spite of CD21 negativity.
  • CONCLUSION: Littoral-cell angioma is a very rare benign splenic neoplasm that should be considered in the differential diagnosis of multinodular splenomegaly, particularly if the patient has the signs of hypersplenism.
  • [MeSH-major] Hemangioma / pathology. Splenic Neoplasms / pathology

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  • (PMID = 19195267.001).
  • [ISSN] 0042-8450
  • [Journal-full-title] Vojnosanitetski pregled
  • [ISO-abbreviation] Vojnosanit Pregl
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Serbia
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / CD68 antigen, human
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36. Broaddus E, Lystad LD, Schonfield L, Singh AD: Iris varix: report of a case and review of iris vascular anomalies. Surv Ophthalmol; 2009 Jan-Feb;54(1):118-27
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  • [Title] Iris varix: report of a case and review of iris vascular anomalies.
  • Iris vascular anomalies are rare benign vascular tumors and simulating lesions of the iris stroma.
  • These can be classified into five distinct, clinicopathological entities: iris capillary hemangioma, iris cavernous hemangioma, iris microhemangioma, iris arteriovenous malformation, and iris varix.
  • We have reviewed all reported cases of iris hemangiomas since 1970, as prior cases have been extensively reviewed by Ferry.
  • Comparative features of each subtype of vascular anomaly are discussed.

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  • (PMID = 19171213.001).
  • [ISSN] 0039-6257
  • [Journal-full-title] Survey of ophthalmology
  • [ISO-abbreviation] Surv Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 36
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37. Bhayana D, Kim TK, Jang HJ, Burns PN, Wilson SR: Hypervascular liver masses on contrast-enhanced ultrasound: the importance of washout. AJR Am J Roentgenol; 2010 Apr;194(4):977-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: The objective of our study was to determine the role of negative enhancement (washout), its presence and timing, in the differential diagnosis of hypervascular liver masses on contrast-enhanced ultrasound.
  • Seventy-four were benign (29 hemangiomas, 31 focal nodular hyperplasia [FNH] lesions, seven adenomas, five inflammatory lesions, two other) and 72, malignant (41 hepatocellular carcinomas [HCCs], 25 metastases, six other).
  • Two independent reviewers retrospectively recorded the presence and timing of washout in the portal venous phase, observing until 4 minutes after injection, of a contrast agent (perflutren microspheres).
  • RESULTS: Washout occurred in both benign (27/74, 36%) and malignant (70/72, 97%) lesions but was more frequently seen in malignancy (p < 0.001) (kappa = 0.91).
  • Among the benign lesions, all five inflammatory lesions showed rapid washout before 75 seconds and six of seven adenomas showed washout, mostly later than 75 seconds (5/6).
  • Washout also occurred in hemangiomas (6/29) and FNH lesions (9/31), mostly later than 75 seconds after injection (12/15).
  • However, washout is not unique to malignancy and may be seen in benign lesions.
  • [MeSH-major] Liver Diseases / ultrasonography. Neovascularization, Pathologic / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Contrast Media. Diagnosis, Differential. Female. Fluorocarbons. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 20308500.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Fluorocarbons; CK0N3WH0SR / perflutren
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38. Zarate YA, Mena R, Martin LJ, Steele P, Tinkle BT, Hopkin RJ: Experience with hemihyperplasia and Beckwith-Wiedemann syndrome surveillance protocol. Am J Med Genet A; 2009 Aug;149A(8):1691-7
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  • Twenty-five (40%) patients had an ultrasound abnormality, the most frequent being nephromegaly/size discrepancy.
  • Three hundred thirty-six separate AFP values were available with values above 50,000 ng/ml seen in three patients older than 2 months, one with hepatoblastoma and two other with hemangiomas/hemangioendotheliomas.
  • In conclusion, ultrasound surveillance detected renal and liver pathology including benign and malignant lesions.

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  • [Copyright] 2009 Wiley-Liss, Inc.
  • (PMID = 19610116.001).
  • [ISSN] 1552-4833
  • [Journal-full-title] American journal of medical genetics. Part A
  • [ISO-abbreviation] Am. J. Med. Genet. A
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / alpha-Fetoproteins
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39. Chatzoulis G, Kaltsas A, Daliakopoulos S, Sallam O, Maria K, Chatzoulis K, Pachiadakis I: Co-existence of a giant splenic hemangioma and multiple hepatic hemangiomas and the potential association with the use of oral contraceptives: a case report. J Med Case Rep; 2008;2:147
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  • [Title] Co-existence of a giant splenic hemangioma and multiple hepatic hemangiomas and the potential association with the use of oral contraceptives: a case report.
  • INTRODUCTION: Hepatic and splenic hemangiomas are common benign tumors that mainly affect female patients.
  • Giant splenic hemangiomas are extremely rare, especially when correlated with multiple hepatic hemangiomas.
  • Pathogenetic mechanisms between hemangiomas and oral contraceptives, as well as therapeutic approaches, are analyzed in this case report, in particular for the management of synchronous splenic and hepatic hemangiomas.
  • CASE PRESENTATION: We report here a 42-year-old woman with a giant splenic hemangioma, multiple hepatic hemangiomas and a history of oral estrogen intake for many years.
  • At first it was difficult to determine the organ from which the giant hemangioma originated.
  • Hematomas in the giant hemangioma posed a significant threat of rupture and catastrophic hemorrhage.
  • We left the small hepatic hemangiomas in place, and removed the spleen along with the giant splenic hemangioma.
  • CONCLUSION: Diagnostic pitfalls in the determination of the origin of this giant hemangioma, attribution of its origin to the spleen angiographically, the unusual co-existence of the giant splenic hemangioma with multiple hepatic ones, and the potential threat of rupture of the giant hemangioma are some of the highlights of this case report.
  • Estrogen administration represents a pathogenic factor that has been associated with hemangiomas in solid organs of the abdominal cavity.
  • The therapeutic dilemma between resection and embolization of giant hemangiomas is another point of discussion in this case report.
  • Splenectomy for the giant splenic hemangioma eliminates the risk of rupture and malignant degeneration, whereas observation for the small hepatic ones (<4 cm) was the preferable therapeutic strategy in our patient.

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  • (PMID = 18462497.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2394533
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40. Doyle DJ, Khalili K, Guindi M, Atri M: Imaging features of sclerosed hemangioma. AJR Am J Roentgenol; 2007 Jul;189(1):67-72
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  • [Title] Imaging features of sclerosed hemangioma.
  • OBJECTIVE: The purpose of this study was to review the imaging features of sclerosed hemangioma.
  • CONCLUSION: In our series, suggestive features of sclerosed hemangiomas include geographic outline, capsular retraction, decrease in size over time, and loss of previously seen regions of enhancement.
  • Additional features include presence of transient hepatic attenuation difference (THAD), rim enhancement, and nodular regions of intense enhancement as seen in typical hemangiomas.
  • Although not pathognomonic, some features of sclerosed hemangioma can suggest it as a diagnostic possibility and lead to biopsy rather than more extensive intervention.
  • [MeSH-major] Gastrointestinal Neoplasms / radiography. Histiocytoma, Benign Fibrous / radiography. Liver Neoplasms / radiography. Tomography, X-Ray Computed / methods

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  • (PMID = 17579154.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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41. Corapçioğlu F, Akansel G, Gönüllü E, Yildiz K, Etuş V: Fatal giant pediatric intracranial cavernous angioma. Turk J Pediatr; 2006 Jan-Mar;48(1):89-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fatal giant pediatric intracranial cavernous angioma.
  • Cavernous angioma is a benign vascular lesion that may occur in the central nervous system.
  • A diagnosis of brain death was made.
  • A cavernous hemangioma was diagnosed with pathologic examination.
  • In conclusion, a cavernous angioma may occasionally follow a rapid and fatal course by causing gross hemorrhage in the pediatric age group.
  • [MeSH-major] Brain Neoplasms / diagnosis. Hemangioma, Cavernous / diagnosis

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  • (PMID = 16562795.001).
  • [ISSN] 0041-4301
  • [Journal-full-title] The Turkish journal of pediatrics
  • [ISO-abbreviation] Turk. J. Pediatr.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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42. Batniji RK, Buckingham ED, Williams EF 3rd: An aesthetic approach to facial hemangiomas. Arch Facial Plast Surg; 2005 Sep-Oct;7(5):301-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An aesthetic approach to facial hemangiomas.
  • Hemangiomas are the most common tumor of infancy and childhood, affecting approximately 10% of infants by the age of 1 year.
  • The diagnosis can nearly always be made by the patient's history and findings on physical examination.
  • Prior to the classification system outlined by Mulliken and Glowacki, the natural course of hemangiomas was poorly understood and treatment was inconsistent, ranging from benign neglect to deforming surgical intervention.
  • However, with an improved understanding of the natural course of hemangiomas, as well as advances in anesthesia, laser technology, medical therapy, and surgical methods, an aesthetic approach to facial hemangiomas was developed by the senior author (E.F.W.) and is reviewed in this article.
  • [MeSH-major] Facial Neoplasms / surgery. Hemangioma / surgery. Surgery, Plastic / methods

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  • (PMID = 16172337.001).
  • [ISSN] 1521-2491
  • [Journal-full-title] Archives of facial plastic surgery
  • [ISO-abbreviation] Arch Facial Plast Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 22
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43. Colović N, Cemerikić-Martinović V, Micev M, Radak V, Colović R: [Hemangioma of the spleen]. Srp Arh Celok Lek; 2006 Jul-Aug;134(7-8):325-7
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  • [Title] [Hemangioma of the spleen].
  • Although the most frequent benign tumors of the spleen, hemangiomas are very rare, much rarer than hemangiomas of the liver.
  • As the investigation showed a number of hypoechogenic lesions within the enlarged, diffusely non-homogenic spleen, splenectomy was indicated.
  • The spleen weighing 2600 grams was removed, in which the number of lesions histologically corresponded to hemangioma of the spleen.
  • [MeSH-major] Hemangioma
  • [MeSH-minor] Aged. Female. Humans. Splenic Neoplasms / diagnosis. Splenic Neoplasms / pathology. Splenic Neoplasms / surgery

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  • (PMID = 17009613.001).
  • [ISSN] 0370-8179
  • [Journal-full-title] Srpski arhiv za celokupno lekarstvo
  • [ISO-abbreviation] Srp Arh Celok Lek
  • [Language] srp
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Serbia and Montenegro
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44. Lee TJ, Collins J: MR imaging evaluation of disorders of the chest wall. Magn Reson Imaging Clin N Am; 2008 May;16(2):355-79, x
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  • Chest wall lesions constitute a diverse group of thoracic diseases, including those of soft tissue and osseous origin.
  • In this article, the authors review common and uncommon diseases of the chest wall, with an emphasis on the MR imaging characteristics of these diseases.
  • Among the diseases they discuss are diseases of the soft tissue including lipoma, hibernoma, liposarcoma, hemangioma, and lymphoma.
  • They also examine diseases of the osseous thorax, including benign osseous tumors, fibrous dysplasia, and aneurysmal bone cyst.
  • [MeSH-major] Bone Neoplasms / diagnosis. Magnetic Resonance Imaging. Soft Tissue Neoplasms / diagnosis. Thoracic Wall

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  • (PMID = 18474337.001).
  • [ISSN] 1064-9689
  • [Journal-full-title] Magnetic resonance imaging clinics of North America
  • [ISO-abbreviation] Magn Reson Imaging Clin N Am
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 137
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45. Szymik-Kantorowicz S, Kobylarz K, Krysta M, Górecki W, Bysiek A, Celmer E, Dzierzega M: Interferon-alpha in the treatment of high-risk haemangiomas in infants. Eur J Pediatr Surg; 2005 Feb;15(1):11-6
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  • [Title] Interferon-alpha in the treatment of high-risk haemangiomas in infants.
  • BACKGROUND: Haemangiomas are benign tumours that may occasionally compress vital structures, or cause consumptive coagulopathy and heart failure.
  • We describe our recent experience with interferon-alpha as a treatment modality for high-risk haemangiomas.
  • PATIENTS AND METHODS: Eight children with high-risk haemangiomas were treated with interferon-alpha, six of which had failed previous steroid therapy.
  • RESULT: Seven children responded to interferon therapy, one boy with a liver haemangioma died.
  • CONCLUSION: Interferon-alpha is an effective treatment modality for high-risk haemangiomas in children, especially in steroid-resistant patients.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Facial Neoplasms / drug therapy. Hemangioma / drug therapy. Interferon-alpha / therapeutic use

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  • [CommentIn] Eur J Pediatr Surg. 2007 Apr;17(2):147 [17503313.001]
  • (PMID = 15795821.001).
  • [ISSN] 0939-7248
  • [Journal-full-title] European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift für Kinderchirurgie
  • [ISO-abbreviation] Eur J Pediatr Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Interferon-alpha
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46. Duxbury MS, Garden OJ: Giant haemangioma of the liver: observation or resection? Dig Surg; 2010;27(1):7-11
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  • [Title] Giant haemangioma of the liver: observation or resection?
  • BACKGROUND: Haemangiomata are the most frequent benign solid liver lesion.
  • The management of giant (> or =5 cm) haemangiomata of the liver remains controversial.
  • RESULTS AND CONCLUSIONS: The vast majority of giant haemangiomata remain asymptomatic and have a benign and uncomplicated natural history.
  • Decisions regarding the optimal management of giant haemangiomata depend on a high level of confidence in diagnostic imaging.
  • Diagnostic biopsy to differentiate giant haemangiomata from malignant lesions should be discouraged.
  • Despite limitations and alternative modalities, surgery remains the only consistently effective curative treatment for giant haemangiomata.
  • Principal indications for the surgical management of giant haemangiomata include established complications, incapacitating symptoms and uncertainty of diagnosis.
  • [MeSH-major] Hemangioma / therapy. Liver Neoplasms / therapy


47. Sterescu AE, Rousseau-Harsany E, Farrell C, Powell J, David M, Dubois J: The potential efficacy of omega-3 fatty acids as anti-angiogenic agents in benign vascular tumors of infancy. Med Hypotheses; 2006;66(6):1121-4
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  • [Title] The potential efficacy of omega-3 fatty acids as anti-angiogenic agents in benign vascular tumors of infancy.
  • Hemangiomas of infancy are benign vascular tumors frequently encountered in pediatrics.
  • Medical treatment (corticosteroids, interferon, chemotherapy, embolization and radiation) in high-risk hemangioma cases could greatly benefit from the addition of new and safer therapies.
  • The rapid growth of hemangiomas during the proliferative phase occurs secondary to a process of local uncontrolled angiogenesis, involving potent mediators such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF).
  • We hypothesize that omega-3 fatty acids, naturally occurring nutrients of proven health benefit to infants, could become an alternative or an adjuvant treatment for hemangiomas, by slowing down their rapid proliferation phase through anti-angiogenic and anti-tumoral effects.
  • In this article, we review recent animal and human studies using dietary omega-3 fatty acids supplements, alone or in conjunction with chemotherapy, for the treatment of a variety of tumors dependent on angiogenesis for growth.
  • Available murine hemangioma models offer the opportunity to determine optimal omega-3 fatty acid dose, while taking in account related immunohistochemical markers, clinical outcome and secondary effects, before planning clinical trials.
  • Lessons learned in hemangiomas of infancy may have a broad impact in understanding the phenomenon of dysregulated angiogenesis in cancer research.
  • [MeSH-major] Angiogenesis Inhibitors / administration & dosage. Fatty Acids, Omega-3 / administration & dosage. Hemangioma / blood supply. Hemangioma / drug therapy. Neovascularization, Pathologic / prevention & control

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  • (PMID = 16500033.001).
  • [ISSN] 0306-9877
  • [Journal-full-title] Medical hypotheses
  • [ISO-abbreviation] Med. Hypotheses
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Fatty Acids, Omega-3
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48. Strom T, Kleinschmidt-Demasters BK, Donson A, Foreman NK, Lillehei KO: Rare nerve lesions of non-nerve sheath origin: a 17-year retrospective series. Arch Pathol Lab Med; 2009 Sep;133(9):1391-402
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  • [Title] Rare nerve lesions of non-nerve sheath origin: a 17-year retrospective series.
  • After elimination of common lesions (mostly nerve sheath tumors), 37 cases (8%) remained, almost all of which were of non-nerve sheath origin: for example, hemangioma, metastatic neuroendocrine pancreatic carcinoma, meningiomas invading nerve fascicles, and primary extrarenal rhabdoid tumor and Ewing sarcoma of nerve.
  • CONCLUSIONS: Diverse benign and malignant conditions can affect peripheral nerve.
  • [MeSH-major] Hemangioma / pathology. Meningioma / pathology. Pancreatic Neoplasms / pathology. Peripheral Nervous System Neoplasms / pathology. Rhabdoid Tumor / pathology. Sarcoma, Ewing / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Diagnosis, Differential. Female. Gene Rearrangement, B-Lymphocyte, Heavy Chain / genetics. Humans. Immunoglobulin Heavy Chains / genetics. In Situ Hybridization, Fluorescence. Male. Middle Aged. Oligonucleotide Array Sequence Analysis. Retrospective Studies. Young Adult

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  • (PMID = 19722745.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Immunoglobulin Heavy Chains
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49. Singh AD, Kaiser PK, Sears JE: Choroidal hemangioma. Ophthalmol Clin North Am; 2005 Mar;18(1):151-61, ix
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  • [Title] Choroidal hemangioma.
  • Choroidal hemangioma is an uncommon benign vascular tumor of the choroid that can be circumscribed or diffuse.
  • Circumscribed choroidal hemangiomas are usually diagnosed between the second to fourth decade of life when they cause visual disturbances owing to the development of an exudative retinal detachment.
  • Circumscribed tumors occur sporadically, without any associated local or systemic anomalies.
  • Diffuse choroidal hemangiomas are usually evident at birth and generally occur as a part of neuro-oculo-cutaneous hemangiomatosis (Sturge-Weber syndrome).
  • [MeSH-major] Choroid Neoplasms / pathology. Hemangioma / pathology
  • [MeSH-minor] Choroid / pathology. Choroid / ultrasonography. Combined Modality Therapy. Diagnosis, Differential. Fluorescein Angiography. Fundus Oculi. Humans. Magnetic Resonance Imaging. Prognosis. Sturge-Weber Syndrome / diagnosis. Sturge-Weber Syndrome / therapy

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  • (PMID = 15763200.001).
  • [ISSN] 0896-1549
  • [Journal-full-title] Ophthalmology clinics of North America
  • [ISO-abbreviation] Ophthalmol Clin North Am
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 55
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50. Güvenç MG, Dereköylü L, Korkut N, Oz F, Oz B: Intravascular papillary endothelial hyperplasia (Masson lesion) of the hypopharynx and larynx. Ear Nose Throat J; 2008 Dec;87(12):700-1
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  • Masson lesion is characterized by a benign intravascular papillary hyperplasia and subsequent thrombosis.
  • Clinically, this lesion can be misdiagnosed as mucocele, hemangioma, Kaposi sarcoma, angiosarcoma, pyogenic granuloma, and several other lesions.
  • We discuss the clinical and histopathologic features, differential diagnosis, and treatment of this uncommon entity.
  • [MeSH-minor] Adolescent. Deglutition Disorders / diagnosis. Deglutition Disorders / etiology. Diagnosis, Differential. Endoscopy / methods. Female. Humans. Severity of Illness Index

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  • (PMID = 19105147.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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51. Yuan SM, Shinfeld A, Kuperstein R, Raanani E: Cavernous hemangioma of the right atrium. Kardiol Pol; 2008 Sep;66(9):974-6
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  • [Title] Cavernous hemangioma of the right atrium.
  • Cardiac hemangioma is a rare primary benign tumour, localised in the right atrium in 23% of cases.
  • Histology revealed it to be a cavernous hemangioma.
  • Due to the potential risks associated with cardiac hemangioma, surgical resection and postoperative follow-up are recommended.
  • [MeSH-major] Heart Neoplasms / diagnosis. Heart Neoplasms / surgery. Hemangioma / diagnosis. Hemangioma / surgery

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  • (PMID = 18924027.001).
  • [ISSN] 0022-9032
  • [Journal-full-title] Kardiologia polska
  • [ISO-abbreviation] Kardiol Pol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
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52. Eftychiou C, Antoniades L: Cardiac hemangioma in the left ventricle and brief review of the literature. J Cardiovasc Med (Hagerstown); 2009 Jul;10(7):565-7
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  • [Title] Cardiac hemangioma in the left ventricle and brief review of the literature.
  • Cardiac hemangiomas are very rare benign cardiac tumors.
  • Diagnosis is usually made with echocardiography and surgical resection is the treatment of choice.
  • We report a case of a 38-year-old man who presented with fatigue and palpitations.
  • It was a smooth oval nodule with a pedicle that was attached to the top of a papillary muscle.
  • Microscopy revealed the presence of numerous vessels within fibrous tissue that ranged from lobules of capillary hemangioma to large thin-walled cavernous vessels, compatible with a hemangioma of mixed capillary-cavernous type.
  • [MeSH-major] Heart Neoplasms / pathology. Hemangioma, Capillary / pathology

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  • (PMID = 19424078.001).
  • [ISSN] 1558-2027
  • [Journal-full-title] Journal of cardiovascular medicine (Hagerstown, Md.)
  • [ISO-abbreviation] J Cardiovasc Med (Hagerstown)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 9
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53. Santoro L, Santini V, Lollo SD, Valeri A, Colagrande S: Hemolymphangiomatosis of the spleen: imaging features. J Comput Assist Tomogr; 2005 Nov-Dec;29(6):831-3
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  • We report a complete imaging study, including magnetic resonance (MR) imaging, after administration of a superparamagnetic contrast agent.
  • Ultrasonography (US), basal MR imaging, and late computed tomography (CT) contrastographic features are quite similar to those of other diffuse benign vascular neoplasms, without real hemangioma-like enhancement during the vascular phase.
  • [MeSH-major] Lymphangioleiomyomatosis / diagnosis. Spleen / pathology. Spleen / radiography. Splenic Neoplasms / diagnosis
  • [MeSH-minor] Adult. Contrast Media / administration & dosage. Dextrans. Female. Ferrosoferric Oxide. Humans. Image Enhancement / methods. Iohexol / analogs & derivatives. Iron. Magnetic Resonance Imaging / methods. Magnetite Nanoparticles. Oxides. Rare Diseases. Splenectomy. Splenomegaly / etiology. Time Factors. Tomography, Spiral Computed / methods

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  • (PMID = 16272860.001).
  • [ISSN] 0363-8715
  • [Journal-full-title] Journal of computer assisted tomography
  • [ISO-abbreviation] J Comput Assist Tomogr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Magnetite Nanoparticles; 0 / Oxides; 4419T9MX03 / Iohexol; 712BAC33MZ / iopromide; E1UOL152H7 / Iron; G6N3J05W84 / ferumoxides; K3R6ZDH4DU / Dextrans; XM0M87F357 / Ferrosoferric Oxide
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54. Yu Q, Yang J, Wang P, Shi H, Luo J: Preliminary assessment of benign maxillofacial and neck lesions with in vivo single-voxel 1H magnetic resonance spectroscopy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2007 Aug;104(2):264-70
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  • [Title] Preliminary assessment of benign maxillofacial and neck lesions with in vivo single-voxel 1H magnetic resonance spectroscopy.
  • OBJECTIVE: The purpose of this study was to assess the potential roles of in vivo single-voxel hydrogen 1 (1H) magnetic resonance (MR) spectroscopy in differentiation of benign maxillofacial and neck lesions.
  • STUDY DESIGN: Fifty-five benign maxillofacial and neck lesions were selected for this study.
  • Choline (Cho) signals were regarded as the criterion to evaluate the differences among the benign lesions.
  • On the PRESS, 8 out of 11 (72.7%) neurogenic tumors, 5 of 7 (71.5%) Warthin tumors, and 4 of 5 (80%) sarcoidosis and sinus histiocytosis were detected with Cho signals, whereas 16 of 19 (84.2%) fluid-filled lesions (hemangiomas, lymphangiomas, and cysts) had no Cho signals.
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Head and Neck Neoplasms / pathology. Magnetic Resonance Imaging / methods
  • [MeSH-minor] Adenolymphoma / diagnosis. Adolescent. Adult. Aged. Choline / metabolism. Cysts / chemically induced. Female. Hemangioma / diagnosis. Histiocytosis / diagnosis. Humans. Lymphangioma / diagnosis. Magnetic Resonance Spectroscopy. Male. Middle Aged. Neoplasms, Nerve Tissue / diagnosis. Protons. Sarcoidosis / diagnosis

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  • (PMID = 17630099.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Protons; N91BDP6H0X / Choline
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55. Chan YC, Giam YC: Guidelines of care for cutaneous haemangiomas. Ann Acad Med Singapore; 2005 Jan;34(1):117-23
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  • [Title] Guidelines of care for cutaneous haemangiomas.
  • INTRODUCTION: Haemangiomas are common benign tumours of the vascular endothelium.
  • RESULTS: An uncomplicated haemangioma can be observed for spontaneous involution.
  • However, some haemangiomas may be life- or function-threatening, or have associated structural anomalies.
  • Interferon alpha, vincristine and cyclophosphamide are therapeutic options for complicated haemangiomas which do not respond to corticosteroids.
  • Vascular-specific pulse dye laser therapy may be considered for superficial haemangiomas, ulcerated haemangiomas or post-involution sequelae like telangiectasia.
  • The mainstay of therapy for ulcerated haemangiomas is good local wound care, analgesics and treatment of secondary infection.
  • A periorbital haemangioma that obstructs the visual axis or exerts pressure on the globe is an ocular emergency.
  • CONCLUSIONS: Medical practitioners should be aware of available therapeutic options for life- or function-threatening haemangiomas.
  • Treatment must be individualised and referral to the relevant specialist should be considered in patients with complicated haemangiomas.
  • [MeSH-major] Hemangioma / therapy. Practice Guidelines as Topic. Skin Neoplasms / therapy
  • [MeSH-minor] Combined Modality Therapy / standards. Diagnosis, Differential. Humans. Singapore

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  • (PMID = 15726230.001).
  • [ISSN] 0304-4602
  • [Journal-full-title] Annals of the Academy of Medicine, Singapore
  • [ISO-abbreviation] Ann. Acad. Med. Singap.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Singapore
  • [Number-of-references] 40
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56. Demir OI, Obuz F, Sağol O, Dicle O: Contribution of diffusion-weighted MRI to the differential diagnosis of hepatic masses. Diagn Interv Radiol; 2007 Jun;13(2):81-6
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  • [Title] Contribution of diffusion-weighted MRI to the differential diagnosis of hepatic masses.
  • PURPOSE: To evaluate the diagnostic contribution of diffusion-weighted magnetic resonance imaging (MRI) using apparent diffusion coefficient (ADC) values to the characterization of hepatic masses and differentiation of benign and malignant lesions.
  • RESULTS: Of the 41 hepatic masses, 24 were benign and 17 were malignant.
  • Benign lesions included 6 cysts, 14 hemangiomas, 2 abscesses, and 2 hydatid cysts.
  • The highest ADC values were for cysts and hemangiomas.
  • The mean ADC value of benign lesions was 2.57 +/- 0.26 x 10(-3)mm(2)/s, whereas malignant lesions had a mean ADC value of 0.86 +/- 0.11 x 10(-3)mm(2)/s.
  • The mean ADC value of benign lesions was significantly higher than that of malignant lesions (P < 0.01).
  • CONCLUSION: Diffusion-weighted MRI with quantitative ADC measurements can be useful in the differentiation of benign and malignant liver lesions.
  • [MeSH-major] Liver Diseases / diagnosis. Magnetic Resonance Imaging / methods
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Liver Neoplasms / diagnosis. Liver Neoplasms / pathology. Male. Middle Aged. Neoplasm Metastasis. Predictive Value of Tests

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  • (PMID = 17562512.001).
  • [ISSN] 1305-3825
  • [Journal-full-title] Diagnostic and interventional radiology (Ankara, Turkey)
  • [ISO-abbreviation] Diagn Interv Radiol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Turkey
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57. Perlmann E, da Silva EG, Guedes PM, Barros PS: Co-existing squamous cell carcinoma and hemangioma on the ocular surface of a cat. Vet Ophthalmol; 2010 Jan;13(1):63-6
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  • [Title] Co-existing squamous cell carcinoma and hemangioma on the ocular surface of a cat.
  • A 14-year-old spayed female domestic short-haired cat was presented for evaluation of a mass in the right eye.
  • Upon microscopic examination, a malignant epithelial neoplasm and a benign vascular neoplasm were present in the cornea.
  • A diagnosis of squamous cell carcinoma (SCC) and hemangioma was made.
  • The SCC was affecting the cornea, bulbar conjunctiva (lateral and inferior) and the base of the third eyelid, whereas the hemangioma was affecting the cornea and medial limbus.
  • To the authors' knowledge, this is the first report of concomitant SCC and hemangioma affecting the ocular surface in a cat.
  • [MeSH-major] Carcinoma, Squamous Cell / veterinary. Cat Diseases / pathology. Eye Neoplasms / veterinary. Hemangioma / veterinary. Neoplasms, Multiple Primary / veterinary


58. Sitaraman LM, Linn JG, Matkowskyj KA, Wayne JD: Sclerosing angiomatoid nodular transformation of the spleen masquerading as a sarcoma metastasis. Rare Tumors; 2010;2(3):e46
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  • Imaging studies and preoperative fine needle biopsy failed to differentiate this lesion from other vascular splenic lesions or a metastatic focus of a prior sarcoma.
  • Although histology can lead to the diagnosis of vascular tumor, immunohistochemistry is the only way to confirm the diagnosis of SANT.
  • SANT of the spleen is a benign lesion that does not recur after splenectomy.

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  • (PMID = 21139961.001).
  • [ISSN] 2036-3613
  • [Journal-full-title] Rare tumors
  • [ISO-abbreviation] Rare Tumors
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2994526
  • [Keywords] NOTNLM ; hamartoma / hemangioendothelioma / histology / immunohistochemistry / littoral cell angioma / lymphangioma / pathology / sarcoma / sclerosing angiomatoid nodular transformation of the spleen / splenic neoplasms / surgery
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59. Guyader D, Latournerie M: [Incidental ultrasound finding of a 3 cm liver nodule in a 45-year-old woman taking hormonal substitution after hysterectomy performed for cervix carcinoma]. Gastroenterol Clin Biol; 2009 Oct;33(10-11 Suppl):F60-7
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  • [Title] [Incidental ultrasound finding of a 3 cm liver nodule in a 45-year-old woman taking hormonal substitution after hysterectomy performed for cervix carcinoma].
  • [Transliterated title] Découverte fortuite d'un nodule hépatique de 3cm à l'échographie chez une femme de 45 ans (sous traitement substitutif hormonal après hystérectomie pour cancer du col de l'utérus).
  • The identification of biliary cyst or hemangioma is usually easy.
  • In other cases, the etiological diagnosis relies on careful radiological analysis of the pattern of the arterial phase enhancement following contrast medium injection.
  • When there is no early arterial enhancement, a liver biopsy is usually indicated to establish the diagnosis.
  • A strong arterial contrast enhancement pattern is indicative of hepatocellular tumor, benign or malignant.
  • In case of cirrhosis, the diagnosis of hepatocellular carcinoma is the most probable.
  • If the non tumorous liver is normal, focal nodular hyperplasia and hepatocellular adenoma should be differentiated.
  • Contrast enhanced MRI and contrast ultrasound are most useful tools for the diagnosis of nodular regenerative hyperplasia but liver biopsy can be necessary in atypical forms.
  • In recent years, the understanding of molecular mechanisms associated with adenoma occurrence allowed for the proposal of a new classification already of practical interest in the management of patients.
  • [MeSH-minor] Carcinoma / surgery. Diagnosis, Differential. Female. Focal Nodular Hyperplasia / ultrasonography. Hormone Replacement Therapy / adverse effects. Humans. Hysterectomy / adverse effects. Incidental Findings. Middle Aged. Predictive Value of Tests. Sensitivity and Specificity. Uterine Cervical Neoplasms / surgery

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  • (PMID = 19766417.001).
  • [ISSN] 0399-8320
  • [Journal-full-title] Gastroentérologie clinique et biologique
  • [ISO-abbreviation] Gastroenterol. Clin. Biol.
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Contrast Media
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60. Giovagnoni A, Giorgi C, Goteri G: Tumours of the spleen. Cancer Imaging; 2005;5:73-7
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  • Tumours of the spleen are rare; however, radiologists need to be aware of the main tumoral features and patterns in order to try to distinguish between benign and malignant masses often discovered incidentally.
  • The principal tumoral masses, benign (cysts, haemangiomas, litteral cell angioma, lymphangioma) and malignant (lymphoma, metastases haemangiosarcoma), are described.
  • [MeSH-major] Diagnostic Imaging. Splenic Neoplasms / diagnosis

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  • [Copyright] Copyright International Cancer Imaging Society.
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  • [ISSN] 1470-7330
  • [Journal-full-title] Cancer imaging : the official publication of the International Cancer Imaging Society
  • [ISO-abbreviation] Cancer Imaging
  • [Language] eng
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  • [Other-IDs] NLM/ PMC1665244
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61. Xu XL, Xu CR, Chen H, Cao YH, Zeng XS, Sun JF, Guo Y: Eruptive microvenular hemangiomas in 4 Chinese patients: clinicopathologic correlation and review of the literature. Am J Dermatopathol; 2010 Dec;32(8):837-40
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  • [Title] Eruptive microvenular hemangiomas in 4 Chinese patients: clinicopathologic correlation and review of the literature.
  • Microvenular hemangioma (MVH) is an uncommon benign vascular neoplasm that usually occurs as a solitary asymptomatic red or purple papule, nodule, or plaque with a predilection for the upper extremities.
  • Clinically, the correct diagnosis of MVH could not be made in any of our patients; however, histologic examination revealed the characteristic features of MVH.
  • The differential diagnosis and review of the literature of patients with multiple MVHs are presented.
  • [MeSH-major] Hemangioma / pathology. Skin Neoplasms / pathology. Venules / pathology
  • [MeSH-minor] Adult. Antigens, CD31 / analysis. Antigens, CD34 / analysis. Biomarkers, Tumor / analysis. Biopsy. China. Diagnosis, Differential. Female. Herpesvirus 8, Human / genetics. Herpesvirus 8, Human / isolation & purification. Humans. Immunohistochemistry. Male. Polymerase Chain Reaction. Predictive Value of Tests. Young Adult. von Willebrand Factor / analysis

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  • (PMID = 20881833.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Antigens, CD34; 0 / Biomarkers, Tumor; 0 / von Willebrand Factor
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62. Islam S, Roustan Delatour NL, Salahdeen SR, Mai KT, Senterman M, Mokhtar GA: Cytologic features of benign solitary pulmonary nodules with radiologic correlation and diagnostic pitfalls: a report of six cases. Acta Cytol; 2009 Mar-Apr;53(2):201-10
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  • [Title] Cytologic features of benign solitary pulmonary nodules with radiologic correlation and diagnostic pitfalls: a report of six cases.
  • BACKGROUND: The solitary pulmonary nodule (SPN) is a common radiologic abnormality often detected incidentally.
  • The majority of SPNs represent benign processes, including granulotmatous inflammation, bronchogenic cysts and hamartomata.
  • CASES: We report the cytologic features of 6 cases of benign SPN: exogenous lipid pneumonia, sclerosing hemangioma, hemartoma, bronchogenic cyst, fungal granuloma and solitary fibrous tumor.
  • CONCLUSION: Cytologically, lack of nuclear atypia with bland chromatin is useful in separating benign from malignant SPN.
  • Radiologically, smaller lesions with smooth, well-defined margins and calcifications are more likely to be benign.
  • Our cases illustrate the cytologic and immunohistochemical features that can help to make a more precise diagnosis.
  • [MeSH-minor] Aged. Biopsy, Fine-Needle. Bronchogenic Cyst / pathology. Bronchogenic Cyst / radiography. Female. Granuloma / microbiology. Granuloma / pathology. Granuloma / radiography. Hamartoma / pathology. Hamartoma / radiography. Humans. Immunohistochemistry. Lung Neoplasms / diagnosis. Lung Neoplasms / pathology. Lung Neoplasms / radiography. Male. Middle Aged. Mycoses / pathology. Mycoses / radiography. Pneumonia, Lipid / pathology. Pneumonia, Lipid / radiography. Retrospective Studies. Tomography, X-Ray Computed

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  • (PMID = 19365977.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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63. Iba Y, Watanabe S, Akimoto T, Abe K, Koyanagi H: Pedicled cardiac hemangioma with right ventricular outflow tract obstruction. Jpn J Thorac Cardiovasc Surg; 2005 May;53(5):269-71
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  • [Title] Pedicled cardiac hemangioma with right ventricular outflow tract obstruction.
  • Histological examination revealed the nature of the tumor to be a benign hemangioma.
  • As reports of cardiac hemangioma causing severe RVOT obstruction are extremely rare, this case warrants attention.
  • [MeSH-major] Heart Neoplasms / complications. Hemangioma / complications. Ventricular Outflow Obstruction / etiology

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  • (PMID = 15952321.001).
  • [ISSN] 1344-4964
  • [Journal-full-title] The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai zasshi
  • [ISO-abbreviation] Jpn. J. Thorac. Cardiovasc. Surg.
  • [Language] eng
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64. Desiate A, Cantore S, Tullo D, Profeta G, Grassi FR, Ballini A: 980 nm diode lasers in oral and facial practice: current state of the science and art. Int J Med Sci; 2009;6(6):358-64
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  • AIM: To evaluate the safety and efficacy of a 980 nm diode laser for the treatment of benign facial pigmented and vascular lesions, and in oral surgery.
  • Vascular lesions: 10 patients (5 small angiomas, 5 telangiectases).
  • [MeSH-major] Hemangioma / surgery. Keratosis / surgery. Labial Frenum / surgery. Lasers, Semiconductor / therapeutic use. Melanosis / surgery. Telangiectasis / surgery

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  • (PMID = 19960121.001).
  • [ISSN] 1449-1907
  • [Journal-full-title] International journal of medical sciences
  • [ISO-abbreviation] Int J Med Sci
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Australia
  • [Other-IDs] NLM/ PMC2786991
  • [Keywords] NOTNLM ; 980 nm Diode Laser / frenulectomy. / pigmented lesions / vascular lesions
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65. Lincoln DT, Singal PK, Al-Banaw A: Growth hormone in vascular pathology: neovascularization and expression of receptors is associated with cellular proliferation. Anticancer Res; 2007 Nov-Dec;27(6B):4201-18
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  • Growth hormone (GH) is mitogenic for a variety of vascular tissue cells, including smooth muscle cells, fibroblasts and endothelial cells and exerts its regulatory functions in controlling metabolism, balanced growth and differentiated cell expression by acting on specific membrane-bound receptors, which trigger a phosphorylation cascade resulting in the modulation of numerous signalling pathways and of gene expression.
  • Essential to the initiation of a cellular response to GH, the presence of receptors for this hormone may predict the adaptation of tumour cells resulting from GH exposure.
  • To address the site/mode of action through which GH exerts its effects, a well characterized monoclonal antibody, obtained by hybridoma technology from Balb/c mice immunized with purified rabbit and rat liver GH-receptor (GHR) and directed against the hormone binding site of the receptor, was applied, using the ABC technique to determine GHR expression in a panel of vascular tumours.
  • A total of 64 benign and malignant vascular tumours were obtained from different human organ sites, including the chest wall, skin, axillary contents, duodenum, female breast, abdomen, stomach, colon, lymph node, bladder, body flank and neck regions.
  • The tumours were of the following pathological entities: Haemangioma (n = 12); haemangioendothelioma (n = 10); Castleman's disease (n = 3), haemangiopericytoma (n = 4); angiosarcoma, (n = 11), Kaposi's sarcoma with focal infiltration by lymphoma, HIV +ve (n = 7), Kaposi's sarcoma (n = 17).
  • The results support the hypothesis that GH is involved in the paracrine-autocrine mechanism, acting locally in regulating vascular tumour growth and will be useful for site-specific studies of the evolution of vascular cancers.
  • [MeSH-minor] Adolescent. Adult. Aged. Animals. Antibodies, Monoclonal / immunology. Antibodies, Monoclonal / pharmacology. Binding Sites. Cell Growth Processes / physiology. Female. Hemangioma / blood supply. Hemangioma / metabolism. Hemangioma / pathology. Humans. Male. Mice. Mice, Inbred BALB C. Middle Aged. Neovascularization, Pathologic / metabolism. Neovascularization, Pathologic / pathology. Rabbits. Rats

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  • [ErratumIn] Anticancer Res. 2008 Mar-Apr;28(2b):1439
  • (PMID = 18225592.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Receptors, Somatotropin; 9002-72-6 / Growth Hormone
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66. Wang HT, Tu Y, Fu CG, Meng RG, Cui L, Xu HL, Yu DH: Diffuse cavernous hemangioma of the rectosigmoid colon. Tech Coloproctol; 2005 Jul;9(2):145-8
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  • [Title] Diffuse cavernous hemangioma of the rectosigmoid colon.
  • Diffuse cavernous hemangioma of the rectosigmoid colon is an uncommon benign vascular lesion.
  • We report 5 cases of diffuse cavernous hemangioma, focusing on the clinical features, diagnosis procedure and treatment.
  • In conclusion, sphincter-saving procedure is most appropriate and curative approach for the treatment of diffuse cavernous hemangioma.
  • Imaging study plays an important role in the diagnosis, preoperative staging and follow-up.
  • [MeSH-major] Hemangioma, Cavernous / diagnosis. Hemangioma, Cavernous / surgery. Rectal Neoplasms / diagnosis. Rectal Neoplasms / surgery. Sigmoid Neoplasms / diagnosis. Sigmoid Neoplasms / surgery

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  • (PMID = 16007358.001).
  • [ISSN] 1123-6337
  • [Journal-full-title] Techniques in coloproctology
  • [ISO-abbreviation] Tech Coloproctol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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67. Yamate J, Izawa T, Kuwamura M, Mitsunaga F, Nakamura S: Vasoformative disorder, resembling littoral cell angioma, of the spleen in a geriatric Japanese macaque (Macaca fuscata). Vet Pathol; 2009 May;46(3):520-5
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  • [Title] Vasoformative disorder, resembling littoral cell angioma, of the spleen in a geriatric Japanese macaque (Macaca fuscata).
  • The enlarged spleen consisted of neoplastic proliferation of anastomosing vascular channels resembling morphologic structures of red pulp sinuses; occasionally, papillary fronds were seen in dilated channels.
  • Based on the pathologic characteristics, particularly the presence of neoplastic cells with macrophage/histiocyte-like attributes, this tumor was regarded as littoral cell angioma; this is a rare benign splenic vascular tumor.
  • [MeSH-major] Hemangioma / veterinary. Macaca. Monkey Diseases / pathology. Splenic Neoplasms / veterinary

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  • (PMID = 19176500.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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68. El Harroudi T, Moumen M, Tijami F, El Otmany A, Jalil A: [Giant epithelioid hemangioma of the hand]. Chir Main; 2008 Oct;27(5):240-2
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  • [Title] [Giant epithelioid hemangioma of the hand].
  • [Transliterated title] Hémangiome épithélioïde géant de la main.
  • Included are benign vascular tumors (epithelioid haemangioma), borderline tumors (epithelioid haemangioendothelioma), and malignant tumors (epithelioid angiosarcoma).
  • We describe a case of epithelioid haemangioma.
  • [MeSH-major] Hand / surgery. Hemangioma / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 18849180.001).
  • [ISSN] 1297-3203
  • [Journal-full-title] Chirurgie de la main
  • [ISO-abbreviation] Chir Main
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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69. Nissim L, Mackstaller L, Hooten J, Motamedi K, Graham A, Taljanovic M: Spindle-cell sarcoma of the popliteal fossa mimicking a benign vascular lesion. Radiol Case Rep; 2010;5(1):340
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  • [Title] Spindle-cell sarcoma of the popliteal fossa mimicking a benign vascular lesion.
  • While some of these tumors may represent de novo malignant transformation of benign entities, others may present with a long indolent course before their invasive nature is apparent.
  • We report the case of a previously healthy 73-year-old female with spindle-cell sarcoma of the left popliteal fossa who initially presented with a painless mass of several months' duration.
  • Magnetic resonance imaging (MRI) suggested a benign vascular lesion/venous angioma, but after the patient's clinical course changed, repeat MRI 18 months later was consistent with an infiltrative soft-tissue malignancy/sarcoma.
  • Three years following the amputation, the patient is free of local tumor recurrence or metastatic disease.

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  • (PMID = 27307844.001).
  • [ISSN] 1930-0433
  • [Journal-full-title] Radiology case reports
  • [ISO-abbreviation] Radiol Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Other-IDs] NLM/ PMC4898174
  • [Keywords] NOTNLM ; CT, computed tomography / MRI, magnetic resonance imaging
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70. Fernandes BF, Castiglione E, Belfort RN, Codère F, Burnier MN Jr: Orbital leiomyoma: histopathologic and immunohistochemical findings of a rare tumor. Ophthal Plast Reconstr Surg; 2009 Jan-Feb;25(1):59-61
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  • [Title] Orbital leiomyoma: histopathologic and immunohistochemical findings of a rare tumor.
  • A 51-year-old man was referred for evaluation of a right orbital hemangioma.
  • On the basis of the histopathologic and immunohistochemical findings, the diagnosis of orbital leiomyoma was established.
  • Although there are no unique features that help the radiologist to exclude other benign lesions of the orbit, the histopathologic diagnosis using immunohistochemical markers is usually straightforward.
  • Attention to the cytologic features that exclude the malignant variant is of utmost relevance for proper diagnosis and patient counseling.

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  • (PMID = 19273932.001).
  • [ISSN] 1537-2677
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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71. Orlandi A, Ferlosio A, Angeloni C, Ciucci A, Giusto Spagnoli L: [Cardiac tumors]. Pathologica; 2005 Jun;97(3):115-23
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  • In the most recent classification, cardiac tumors are divided into benign (about 75% and malignant neoplasms in relationship to their tissue differentiation (rhabdomyoma, haemangioma, etc.) or uncertain aetiology (myxoma, papillary fibroelastoma).
  • Although non-invasive technologies as trans-esophageal ecocardiography allow the detection and exact localization of cardiac mass, clinical diagnosis is often tardive.
  • This is due, besides the intrinsic rarity, to two main factors: first, the tumor is often asymptomatic (incidental autopic finding) or; alternatively, it may show aspecif symptoms mimicking heart failure or other pathologies.
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Glomus Tumor / pathology. Hemangioma / pathology. Humans. Male. Middle Aged. Myxoma / genetics. Myxoma / pathology. Neoplasm Proteins / analysis. Papilloma / pathology. Pericytes / pathology. Rhabdomyoma / pathology. Sarcoma / chemistry. Sarcoma / pathology

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  • (PMID = 16259277.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins
  • [Number-of-references] 29
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72. Chen WL, Zhang B, Li JS, Yang ZH, Wang YJ, Huang ZQ, Ye YS: Liquid nitrogen cryotherapy of lip mucosa hemangiomas under inhalation general anesthesia with sevoflurane in early infancy. Ann Plast Surg; 2009 Feb;62(2):154-7
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  • [Title] Liquid nitrogen cryotherapy of lip mucosa hemangiomas under inhalation general anesthesia with sevoflurane in early infancy.
  • Mucous membrane hemangiomas of the lip are common benign vascular tumors of infancy.
  • This clinical study evaluated the efficacy and safety of liquid nitrogen cryotherapy of mucous membrane hemangiomas of the lip in early infancy.
  • It was a retrospective review of 127 pediatric patients with hemangiomas involving the lips who underwent liquid nitrogen cryotherapy under inhalation general anesthesia with sevoflurane.
  • The overall median age at diagnosis of the mucous membrane hemangiomas was 3.6 months (range, 7 days to 18 months).
  • The oral mucous membrane hemangioma involved the vermilion of the lower lip in 78 cases (61.4%), the vermilion of the upper lip in 40 cases (31.5%), and both vermilions in 9 cases (7.1%).
  • Liquid nitrogen cryotherapy is an effective, simple, and safe treatment for mucous membrane hemangiomas of the lip in early infancy.
  • [MeSH-major] Anesthesia, Inhalation. Anesthetics, Inhalation / administration & dosage. Cryotherapy / methods. Hemangioma / surgery. Lip Neoplasms / surgery. Methyl Ethers / administration & dosage. Mouth Mucosa

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  • (PMID = 19158525.001).
  • [ISSN] 1536-3708
  • [Journal-full-title] Annals of plastic surgery
  • [ISO-abbreviation] Ann Plast Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anesthetics, Inhalation; 0 / Methyl Ethers; 38LVP0K73A / sevoflurane; N762921K75 / Nitrogen
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73. Jung SH, Jung S, Moon KS, Park HW, Kang SS: Tailored surgical approaches for benign craniovertebral junction tumors. J Korean Neurosurg Soc; 2010 Aug;48(2):139-44
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  • [Title] Tailored surgical approaches for benign craniovertebral junction tumors.
  • OBJECTIVE: We report our surgical experience in the treatment of 16 consecutive patients with benign craniovertebral junction (CVJ) tumor, observed from 2003 to 2008 at our department.
  • METHODS: We had treated 6 foramen magnum meningiomas, 6 cervicomedullary hemangioblastomas, 1 accessory nerve schwannoma, 1 hypoglossal nerve schwannoma, 1 C2 root schwannoma, and 1 cavernous hemangioma.

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  • (PMID = 20856663.001).
  • [ISSN] 1598-7876
  • [Journal-full-title] Journal of Korean Neurosurgical Society
  • [ISO-abbreviation] J Korean Neurosurg Soc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2941857
  • [Keywords] NOTNLM ; Benign tumor / Complication / Craniovertebral junction / Neuroradiology / Surgical resection
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74. Rocourt DV, Shiels WE, Hammond S, Besner GE: Contemporary management of benign hepatic adenoma using percutaneous radiofrequency ablation. J Pediatr Surg; 2006 Jun;41(6):1149-52
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  • [Title] Contemporary management of benign hepatic adenoma using percutaneous radiofrequency ablation.
  • Hepatic adenoma is a benign liver tumor that occurs primarily in women.
  • The authors present an unusual case report of a histologically proven benign hepatic adenoma occurring in an adolescent boy treated with percutaneous radiofrequency ablation (RFA).
  • Magnetic resonance imaging scan revealed a lobular solid mass in the posterior segment of the right lobe of the liver that did not have the classic appearance of a hemangioma.
  • Histologic examination revealed a benign liver adenoma.
  • Traditionally, surgical resection has been the mainstay of therapy for the treatment of benign hepatic adenoma.

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  • (PMID = 16769351.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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75. Nicolau C, Vilana R, Catalá V, Bianchi L, Gilabert R, García A, Brú C: Importance of evaluating all vascular phases on contrast-enhanced sonography in the differentiation of benign from malignant focal liver lesions. AJR Am J Roentgenol; 2006 Jan;186(1):158-67
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  • [Title] Importance of evaluating all vascular phases on contrast-enhanced sonography in the differentiation of benign from malignant focal liver lesions.
  • OBJECTIVE: Our objective was to evaluate the accuracy of a blood-pool sonographic contrast agent in the late phase compared with the three vascular phases for differentiation between benign and malignant focal liver lesions.
  • SUBJECTS AND METHODS: In 152 patients (105 with chronic liver disease), 152 solid focal liver lesions characterized either by fine-needle biopsy or by dynamic CT or MRI were studied.
  • The final diagnoses were metastasis for 24, hepatocellular carcinoma for 75, focal nodular hyperplasia for 13, regenerating or dysplastic nodule for 14, hemangioma for 22, cholangiocarcinoma for two, and another focal liver lesion for two.
  • All lesions were evaluated in the arterial, portal, and late phases; classified as benign or malignant; and correlated with final diagnoses.
  • RESULTS: For discrimination between malignant and benign focal liver lesions, evaluation of all vascular phases improved the sensitivity from 78.4% to 98% and the accuracy from 80.9% to 92.7%, compared with evaluation of the late phase alone.
  • The increase in accuracy was higher in patients with chronic liver disease (16.3%) than in those without (2.1%).
  • CONCLUSION: Evaluation of SonoVue enhancement in all three vascular phases is superior to evaluation of SonoVue enhancement in the late phase alone, especially in patients with chronic liver disease.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Contrast Media. Diagnosis, Differential. Humans. Middle Aged. Neoplasm Metastasis. Phospholipids. Prospective Studies. Sensitivity and Specificity. Statistics, Nonparametric. Sulfur Hexafluoride

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  • (PMID = 16357396.001).
  • [ISSN] 0361-803X
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Phospholipids; 0 / contrast agent BR1; WS7LR3I1D6 / Sulfur Hexafluoride
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76. Williams K, Flanagan A, Folpe A, Thakker R, Athanasou NA: Lymphatic vessels are present in phosphaturic mesenchymal tumours. Virchows Arch; 2007 Nov;451(5):871-5
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  • Oncogenic osteomalacia (OO) is an acquired form of hypophosphataemic osteomalacia, which is associated most commonly with the development of a benign phosphaturic mesenchymal tumour mixed connective tissue type (PMTMCT).
  • PMTMCTs are generally well vascularised tumours, and many have in the past been classified as haemangiomas and haemangiopericytomas.
  • Using monoclonal antibodies directed against several vascular markers, including the lymphatic endothelial cell antigens LYVE 1 and podoplanin, we found that PMTMCTs, in contrast to haemangiomas and haemangiopericytomas, contain lymphatic vessels.
  • Taken with previous observations that PMTMCTs overexpress FGF23 and other gene products, this finding provides further evidence that most osteomalacia associated mesenchymal tumours represent a discrete pathological entity.

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  • (PMID = 17674036.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Membrane Glycoproteins; 0 / PDPN protein, human; 0 / Phosphates; 0 / fibroblast growth factor 23; 62031-54-3 / Fibroblast Growth Factors
  • [Number-of-references] 23
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77. Tomuş C, Iancu C, Bălă O, Graur F, Furcea L, Zaharie F, Mocan L, Vlad L: [Liver resection for benign hepatic lesion: mortality, morbidity and risk factors for postoperative complications]. Chirurgia (Bucur); 2009 May-Jun;104(3):275-80
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  • [Title] [Liver resection for benign hepatic lesion: mortality, morbidity and risk factors for postoperative complications].
  • [Transliterated title] Hepatectomiile pentru leziuni focale hepatice benigne: mortalitate, morbiditate şi factorii de risc corelaţi cu complicaţiile postoperatorii.
  • The aim of this study was to evaluate the result of liver resection for benign hepatic lesion and to determine the risk factors for postoperative complication.
  • Between January 2001 and December 2006 (6 years), a total of 50 patients with benign hepatic lesion underwent hepatic resection and were retrospectively reviewed.
  • The diagnosis was: hydatid cyst in 24 patients (48%); hemangioma in 14 patients (28%), focal nodular hyperplasia (FNH) in 6 (12%), hepatic adenoma in 3 cases (6%), and hepatoblastoma in 3 patients (6%).
  • Liver resections for benign hepatic lesion performed in specialized centers are safe and efficient, with low morbidity and mortality.
  • [MeSH-major] Hepatectomy / methods. Liver Diseases / mortality. Liver Diseases / surgery

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  • (PMID = 19601458.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] rum
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Romania
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78. Suurmeijer AJ, Fletcher CD: Papillary haemangioma. A distinctive cutaneous haemangioma of the head and neck area containing eosinophilic hyaline globules. Histopathology; 2007 Nov;51(5):638-48
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  • [Title] Papillary haemangioma. A distinctive cutaneous haemangioma of the head and neck area containing eosinophilic hyaline globules.
  • AIMS: To investigate and define a morphologically distinctive group of cutaneous papillary haemangiomas.
  • None of the patients had associated systemic disease or polyneuropathy, organomegaly, endocrinopathy, M-protein, skin changes (POEMS) syndrome.
  • CONCLUSIONS: Papillary haemangioma is a distinctive benign cutaneous lesion containing eosinophilic hyaline globules consistent with dysfunction of the autophagocytic-lysosomal pathway.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Hemangioma / pathology. Hyalin / ultrastructure. Skin Neoplasms / pathology

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  • (PMID = 17927585.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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79. Reis RM, Reis-Filho JS, Longatto Filho A, Tomarev S, Silva P, Lopes JM: Differential Prox-1 and CD 31 expression in mucousae, cutaneous and soft tissue vascular lesions and tumors. Pathol Res Pract; 2005;201(12):771-6
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  • Here, we describe a double-immunostaining strategy for formalin-fixed, paraffin-embedded tissues that aims at evaluating the distribution of Prox-1 and CD 31 - a cytoplasmic pan-endothelial marker - in a series of 28 mucousae, cutaneous and soft tissue vascular lesions and tumors, including hemangiomas, lymphangiomas, lymphangiectasia, and Kaposi's sarcomas.
  • Our results showed that in non-lesional mucousae and skin, Prox-1 decorated exclusively the nuclei of endothelial cells in lymphatic vessels.
  • Prox-1 stained almost all the benign lymphatic vascular lesions/tumors (91%) and was absent or only focally positive in 75% of blood vascular tumors.
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers / analysis. Child. Child, Preschool. Female. Hemangioma / metabolism. Humans. Immunohistochemistry. Infant. Infant, Newborn. Lymphangioma / metabolism. Lymphatic Vessels / metabolism. Male. Middle Aged. Sarcoma, Kaposi / metabolism. Tumor Suppressor Proteins

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  • (PMID = 16308102.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Biomarkers; 0 / Homeodomain Proteins; 0 / Tumor Suppressor Proteins; 0 / prospero-related homeobox 1 protein
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80. Montgomery E, Epstein JI: Anastomosing hemangioma of the genitourinary tract: a lesion mimicking angiosarcoma. Am J Surg Pathol; 2009 Sep;33(9):1364-9
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  • [Title] Anastomosing hemangioma of the genitourinary tract: a lesion mimicking angiosarcoma.
  • BACKGROUND: We describe 6 cases of a poorly recognized vascular neoplasm that can simulate angiosarcoma.
  • DESIGN: Cases of a rare vascular tumor with a proclivity for the genitourinary tract encountered in our consultation material were prospectively collected between the year 1999 and 2008.
  • CONCLUSIONS: Anastomosing hemangioma of the genitourinary tract is a rare neoplasm displaying some overlapping features of both sinusoidal hemangioma and hobnail hemangioma of soft tissue and skin.
  • Its anastomosing appearance can lead to concern for angiosarcoma but, despite small numbers and limited follow-up in our series, evidence to date supports that the lesion is benign.
  • [MeSH-major] Hemangioma / pathology. Hemangiosarcoma / pathology. Urogenital Neoplasms / pathology
  • [MeSH-minor] Aged. Antigens, CD31 / analysis. Antigens, CD34 / analysis. Biomarkers, Tumor / analysis. Diagnosis, Differential. Factor VIII / analysis. Female. Humans. Kidney Neoplasms / chemistry. Kidney Neoplasms / pathology. Male. Middle Aged. Prospective Studies. Testicular Neoplasms / chemistry. Testicular Neoplasms / pathology. Treatment Outcome

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  • (PMID = 19606014.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Antigens, CD34; 0 / Biomarkers, Tumor; 0 / F8 protein, human; 9001-27-8 / Factor VIII
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81. Arkadopoulos N, Stafyla V, Karapanos K, Yiallourou AI, Koureas A, Kondi-Pafiti A, Smyrniotis V: Recurrent pulmonary embolism due to giant hepatic hamangioma treated with hepatectomy under vascular exclusion. Ann Vasc Surg; 2010 Aug;24(6):827.e1-3
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  • Giant hepatic hemangiomas are benign tumors that measure more than 4 cm and are usually asymptomatic.
  • Pulmonary embolism (PE) is an extremely rare manifestation of giant hepatic hemangiomas.
  • We report a case of a 44-year-old woman who suffered of recurrent pulmonary emboli that, after thorough work up, were attributed to thrombi formation inside a giant hepatic hemangioma.
  • A right hepatectomy under vascular exclusion was performed and the hemangioma, measuring 17 cm, was resected.
  • The report highlights the value of investigating giant liver hemangiomas in case of PE.
  • In such cases, the hemangioma should be resected preferably under occlusion of the venous outflow of the liver to avoid PE intraoperatively.
  • [MeSH-major] Hemangioma / surgery. Hepatectomy. Hepatic Veins / surgery. Liver Neoplasms / surgery. Portal System / surgery. Pulmonary Embolism / prevention & control

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  • [Copyright] Copyright 2010 Annals of Vascular Surgery Inc. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20471202.001).
  • [ISSN] 1615-5947
  • [Journal-full-title] Annals of vascular surgery
  • [ISO-abbreviation] Ann Vasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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82. Alves S, Junqueira JL, de Oliveira EM, Pieri SS, de Magalhães MH, Dos Santos Pinto D Jr, Mantesso A: Condylar hemangioma: report of a case and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2006 Nov;102(5):e23-7
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  • [Title] Condylar hemangioma: report of a case and review of the literature.
  • According to the World Health Organization, hemangiomas are benign vasoformative neoplasms or developmental conditions of endothelial origin.
  • The differential diagnosis between high and low flow vascular lesions is crucial for successful treatment, decreasing the occurrence of serious intraoperative hemorrhage.
  • The clinical, radiographic, and pathological features of an intraosseous vascular lesion in the mandibular condyle in a 22-year-old male are presented, and the differential diagnostic aspects between hemangioma, vascular malformation, and high or low flow lesions are discussed.
  • [MeSH-major] Hemangioma / pathology. Mandibular Condyle / pathology. Mandibular Neoplasms / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male

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  • (PMID = 17052619.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 15
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83. Turkoz R, Gulcan O, Oguzkurt L, Atalay H, Bolat B, Sezgin A: Surgical treatment of a huge cavernous hemangioma surrounding the right coronary artery. Ann Thorac Surg; 2005 May;79(5):1765-7
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  • [Title] Surgical treatment of a huge cavernous hemangioma surrounding the right coronary artery.
  • Hemangioma of the heart is an extremely rare benign cardiac tumor.
  • A 61-year-old woman presented with a huge hemangioma on the right ventricle.
  • [MeSH-major] Coronary Vessels. Hemangioma, Cavernous / surgery. Neoplasms, Vascular Tissue / surgery

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  • (PMID = 15854977.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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84. Forner A, Vilana R, Ayuso C, Bianchi L, Solé M, Ayuso JR, Boix L, Sala M, Varela M, Llovet JM, Brú C, Bruix J: Diagnosis of hepatic nodules 20 mm or smaller in cirrhosis: Prospective validation of the noninvasive diagnostic criteria for hepatocellular carcinoma. Hepatology; 2008 Jan;47(1):97-104
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  • [Title] Diagnosis of hepatic nodules 20 mm or smaller in cirrhosis: Prospective validation of the noninvasive diagnostic criteria for hepatocellular carcinoma.
  • This study prospectively evaluates the accuracy of contrast-enhanced ultrasound (CEUS) and dynamic magnetic resonance imaging (MRI) for the diagnosis of nodules 20 mm or smaller detected during ultrasound (US) surveillance.
  • Non-HCC cases were followed (median 23 months) by CEUS/3 months and MRI/6 months.
  • Final diagnoses were: HCC (n = 60), cholangiocarcinoma (n = 1), and benign lesions (regenerative/dysplastic nodule, hemangioma, focal nodular hyperplasia) (n = 28).
  • Sex, cirrhosis cause, liver function, and alpha-fetoprotein (AFP) levels were similar between HCC and non-HCC groups.
  • Thus, diagnosis of HCC 20 mm or smaller can be established without a positive biopsy if both CEUS and MRI are conclusive.
  • However, sensitivity of these noninvasive criteria is 33% and, as occurs with biopsy, absence of a conclusive pattern does not rule out malignancy.
  • These results validate the American Association for the Study of Liver Disease (AASLD) guidelines.

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  • [CommentIn] Hepatology. 2008 Jun;47(6):2145-6; author reply 2146-7 [18508292.001]
  • [CommentIn] Hepatology. 2008 Jun;47(6):2145; author reply 2146-7 [18508306.001]
  • [ErratumIn] Hepatology. 2008 Feb;47(2):769
  • (PMID = 18069697.001).
  • [ISSN] 1527-3350
  • [Journal-full-title] Hepatology (Baltimore, Md.)
  • [ISO-abbreviation] Hepatology
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / 1R01DK076986-0
  • [Publication-type] Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Validation Studies
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
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85. Clauser L, Mandrioli S, Polito J, Galiè M: Surgical techniques for the removal of forehead hemangioma. J Craniofac Surg; 2006 Jul;17(4):702-4
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  • [Title] Surgical techniques for the removal of forehead hemangioma.
  • Hemangiomas of the bone are rare tumors, accounting for 0.5-1% of all benign skeletal tumors.
  • The authors, after reviewing the literature, describe their experience with a case of frontal bone hemangioma.
  • [MeSH-major] Frontal Bone / surgery. Hemangioma, Cavernous / surgery. Skull Neoplasms / surgery

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  • (PMID = 16877918.001).
  • [ISSN] 1049-2275
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 15
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86. Rødahl E, Lybaek H, Arnes J, Ness GO: Chromosomal imbalances in some benign orbital tumours. Acta Ophthalmol Scand; 2005 Jun;83(3):385-91
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  • [Title] Chromosomal imbalances in some benign orbital tumours.
  • PURPOSE: To examine benign orbital tumours for chromosomal imbalances.
  • RESULTS: Chromosomal gains or losses were seen in 4/6 pleomorphic adenomas (gains at 8q; losses at 4p, 5p, 8p, 11p and 14q), 2/4 schwannomas (losses at 16p and 22q), and 1/9 cavernous haemangiomas (losses at 13q).
  • Gains of 8q11-q22 and losses of 4p15-pter, 11p12-p15, and 14q12-q23 in pleomorphic adenomas, losses of 16p12-p13 in schwannomas, and losses of 13q32-qter in cavernous haemangiomas have not been reported previously.
  • CONCLUSIONS: A range of chromosomal imbalances was detected even within tumours of the same histological subtype.
  • [MeSH-major] Adenoma, Pleomorphic / genetics. Chromosome Aberrations. Hemangioma, Cavernous / genetics. Neurilemmoma / genetics. Orbital Neoplasms / genetics

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  • (PMID = 15948796.001).
  • [ISSN] 1395-3907
  • [Journal-full-title] Acta ophthalmologica Scandinavica
  • [ISO-abbreviation] Acta Ophthalmol Scand
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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87. Santarpia L, Sarlis NJ, Santarpia M, Sherman SI, Trimarchi F, Benvenga S: Mosaicism in von Hippel-Lindau disease: an event important to recognize. J Cell Mol Med; 2007 Nov-Dec;11(6):1408-15
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  • [Title] Mosaicism in von Hippel-Lindau disease: an event important to recognize.
  • von Hippel-Lindau disease (VHL) is an autosomal dominant, familial neoplastic disorder with variable interfamilial and intrafamilial expression.
  • VHL is characterized by pre-disposition to development of a combination of benign and malignant tumours affecting multiple organs.
  • The mosaic subject was found to have a cyst of the kidney and an angioma of the glans penis and had had surgery for a mandibular cyst and epididymal cystadenomas.
  • The real incidence of mosaicism is still unclear and the identification of mosaicism has important consequences in genetic counseling of VHL patients who appear to have de novo VHL mutations and should be considered when evaluating patients with isolated VHL-related tumours.
  • Our results strongly suggest a complete and extensive clinical examination in the parents of each patient affected by an apparently de novo VHL germline mutation.
  • We recommend performing a mutation screening of both parents of a proband with techniques that permit detection of low percentages of mosaicism before concluding that the proband has a de novo VHL mutation.
  • [MeSH-major] Mosaicism. von Hippel-Lindau Disease / genetics

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  • (PMID = 18205710.001).
  • [ISSN] 1582-1838
  • [Journal-full-title] Journal of cellular and molecular medicine
  • [ISO-abbreviation] J. Cell. Mol. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Romania
  • [Chemical-registry-number] EC 6.3.2.19 / VHL protein, human; EC 6.3.2.19 / Von Hippel-Lindau Tumor Suppressor Protein
  • [Other-IDs] NLM/ PMC4401302
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88. Gönül M, Gul U, Gunduz H, Artantas S, Demiriz M: Disseminated lobular capillary hemangioma: two case reports. J Dermatol; 2005 Dec;32(12):996-9
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  • [Title] Disseminated lobular capillary hemangioma: two case reports.
  • Lobular capillary hemangioma, also known as pyogenic granuloma, is a common, solitary, benign neoplasm of the skin and mucous membranes.
  • Lobular capillary hemangioma can present rarely in a disseminated form, usually associated with other disorders.
  • Two patients, aged 17 and 33, were admitted to the dermatology clinic with disseminated lobular capillary hemangiomas which appeared suddenly.
  • The histopathology of the lesions was consistent with lobular capillary hemangioma.
  • No associated disorders were found in physical and laboratory examinations other than mental retardation in one patient and a small hemangioma in the liver in the other.
  • We report two cases of disseminated lobular capillary hemangioma without an associated disorder.
  • [MeSH-major] Granuloma, Pyogenic / pathology. Skin Diseases / pathology


89. Tak WY, Park SY, Jeon SW, Cho CM, Kweon YO, Kim SK, Choi YH, Chung JM: Ultrasonography-guided percutaneous radiofrequency ablation for treatment of a huge symptomatic hepatic cavernous hemangioma. J Clin Gastroenterol; 2006 Feb;40(2):167-70
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  • [Title] Ultrasonography-guided percutaneous radiofrequency ablation for treatment of a huge symptomatic hepatic cavernous hemangioma.
  • Hepatic cavernous hemangioma is the most common benign tumor of the liver.
  • We have accumulated a number of cases with successful management of local hepatic tumors.
  • Here we report a case where we performed an ultrasound-guided percutaneous radiofrequency ablation for the treatment of a symptomatic hemangioma.
  • A 36-year-old female patient visited Kyungpook National University Hospital because of persistent right upper abdominal pain caused by an enlarging hemangioma.
  • After two sessions of radiofrequency ablation, the hemangioma was significantly reduced in size.
  • After 36 months, a follow-up abdominal CT revealed remarkably diminished necrotic areas of ablated hemangioma.
  • The size of hemangioma was decreased to almost one third of the original longitudinal diameter.
  • The patient remains asymptomatic in regards to the hemangioma.
  • [MeSH-major] Catheter Ablation. Hemangioma, Cavernous / surgery. Liver Neoplasms / surgery. Ultrasonography, Interventional

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  • (PMID = 16394880.001).
  • [ISSN] 0192-0790
  • [Journal-full-title] Journal of clinical gastroenterology
  • [ISO-abbreviation] J. Clin. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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90. Luna A, Ribes R, Caro P, Vida J, Erasmus JJ: Evaluation of cardiac tumors with magnetic resonance imaging. Eur Radiol; 2005 Jul;15(7):1446-55
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  • Primary cardiac neoplasms are rare, and are more commonly benign than malignant.
  • Specific tumoral characterization is only possible in cases of myxoma, lipoma, fibroma and hemangioma.
  • [MeSH-major] Heart Neoplasms / diagnosis. Magnetic Resonance Imaging / methods

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  • [CommentIn] Eur Radiol. 2006 Aug;16(8):1858-9 [16583217.001]
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  • (PMID = 15627179.001).
  • [ISSN] 0938-7994
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media
  • [Number-of-references] 33
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91. Kim SY, Jeon TJ, Hong JH, Kim GS, Oh TH, Seo DD, Shin WC, Choi WC: [An adult case of small bowel intussusception caused by hemangioma presenting with intestinal bleeding]. Korean J Gastroenterol; 2008 Sep;52(3):183-7
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  • [Title] [An adult case of small bowel intussusception caused by hemangioma presenting with intestinal bleeding].
  • Intussusception is primarily a disease of children, and is relatively rare in adults.
  • Unlike childhood intussusception, adult intussusception has an identifiable leading lesion such as malignant or benign neoplasm.
  • However, intussusception caused by hemangioma is very rare.
  • There were few cases of small bowel intussusception caused by hemangioma in adults, but those reports were presented with abdominal pain.
  • This report describes a 65-year-old female who suffered from small bowel intussusception caused by hemangioma presenting with intestinal bleeding.
  • This mass turned out to be a hemangioma after the small bowel resection.
  • Therefore, small bowel intussusception by hemangioma should be also considered as a bleeding focus when an adult patient presented intestinal bleeding without bleeding focus in the stomach and colon.
  • Herein we report a case of small bowel intussusception caused by hemangioma presenting with intestinal bleeding.
  • [MeSH-major] Gastrointestinal Hemorrhage / etiology. Hemangioma / complications. Intestinal Neoplasms / complications. Intestine, Small. Intussusception / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Tomography, X-Ray Computed

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  • (PMID = 19077515.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Korea (South)
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92. Huang YL, Chen JH, Shen WC: Diagnosis of hepatic tumors with texture analysis in nonenhanced computed tomography images. Acad Radiol; 2006 Jun;13(6):713-20
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  • [Title] Diagnosis of hepatic tumors with texture analysis in nonenhanced computed tomography images.
  • RATIONALE AND OBJECTIVES: Computed tomography (CT) after iodinated contrast agent injection is highly accurate for diagnosis of hepatic tumors.
  • We aimed to evaluate the potential role of the computer-aided diagnosis (CAD) with texture analysis in the differential of hepatic tumors on nonenhanced CT.
  • MATERIALS AND METHODS: This study evaluated 164 liver lesions (80 malignant tumors and 84 hemangiomas).
  • Proposed preprocessing adjustments for subimages were used to equalize the information needed for a differential diagnosis.
  • The autocovariance texture features of subimage were extracted and a support vector machine classifier identified the tumor as benign or malignant.
  • RESULTS: The accuracy of the proposed diagnosis system for classifying malignancies is 81.7%, the sensitivity is 75.0%, the specificity is 88.1%, the positive predictive value is 85.7%, and the negative predictive value is 78.7%.
  • CONCLUSIONS: This system differentiates benign from malignant hepatic tumors with relative high accuracy and is therefore clinically useful to reduce patients needed for iodinated contrast agent injection in CT examination.

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  • (PMID = 16679273.001).
  • [ISSN] 1076-6332
  • [Journal-full-title] Academic radiology
  • [ISO-abbreviation] Acad Radiol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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93. Puso C, Guillot B, Durand L, Guilhou JJ, Bessis D: [Capillary malformations associated with cerebral cavernous malformation]. Ann Dermatol Venereol; 2005 May;132(5):471-4
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  • [Transliterated title] Malformations capillaires associées à un angiome caverneux cérébral.
  • INTRODUCTION: Capillary malformations such as benign hereditary telangiectasia are a familial affection, of dominant autosomal transmission, characterized by the progressive development of cutaneous telangiectasia during childhood.
  • The familial history of telangiectasic macules and clinical and histological examination led to the diagnosis of benign hereditary telangiectasia.
  • DISCUSSION: This case report raises doubt on the exclusively cutaneous nature of benign hereditary telangiectasic-type capillary malformations.
  • Moreover, it illustrates the possibility of a particular clinical form of this affection, associating classical telangiectasia and post-wine stain-type macules.
  • The recent localization of the locus implied in this affection in 5q14 in the same chromosomic space as the CMC1 locus incriminated in familial capillary malformations, suggests that these two affections are in fact phenotype variations of a single and same clinical entity.
  • [MeSH-major] Central Nervous System Vascular Malformations / complications. Central Nervous System Vascular Malformations / pathology. Hemangioma, Cavernous / complications. Hemangioma, Cavernous / pathology

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  • (PMID = 15988361.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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94. Chung EM, Cube R, Lewis RB, Conran RM: From the archives of the AFIP: Pediatric liver masses: radiologic-pathologic correlation part 1. Benign tumors. Radiographics; 2010 May;30(3):801-26
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  • [Title] From the archives of the AFIP: Pediatric liver masses: radiologic-pathologic correlation part 1. Benign tumors.
  • Benign hepatic tumors in children include lesions that are unique to the pediatric age group and others that are more common in adults.
  • Infantile hemangioendothelioma, or infantile hepatic hemangioma, is a benign vascular tumor that may cause serious clinical complications.
  • Benign epithelial tumors that are common in adults may infrequently occur in childhood.
  • Knowledge of how the pathologic features of these tumors affect their imaging appearances helps radiologists offer an appropriate differential diagnosis and management plan.
  • [MeSH-major] Diagnostic Imaging / methods. Liver Neoplasms / diagnosis

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  • (PMID = 20462995.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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95. Guldbakke KK, Rørdam OM, Huldt-Nystrøm T, Hanssen HK, Høivik F: [Propanolol used in treatment of infantile hemangioma]. Tidsskr Nor Laegeforen; 2010 Sep 23;130(18):1822-4
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  • [Title] [Propanolol used in treatment of infantile hemangioma].
  • [Transliterated title] Behandling av infantilt hemangiom med propanolol.
  • BACKGROUND: Infantile hemangiomas are benign vascular tumors that affect 8-12 % of infants.
  • MATERIAL AND METHODS: The article is based on literature retrieved through a non-systematic search in Pubmed, and our own experience in using propanolol for treatment of a patient with infantile hemangioma.
  • Literature describes reduced size and changes in the colour of hemangiomas within 24-48 hours.
  • INTERPRETATION: Propanolol seems to be an effective treatment of infantile hemangiomas.
  • [MeSH-major] Adrenergic beta-Antagonists / therapeutic use. Eye Neoplasms / drug therapy. Hemangioma / drug therapy. Propranolol / therapeutic use. Skin Neoplasms / drug therapy

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  • (PMID = 20882080.001).
  • [ISSN] 0807-7096
  • [Journal-full-title] Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række
  • [ISO-abbreviation] Tidsskr. Nor. Laegeforen.
  • [Language] nor
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Norway
  • [Chemical-registry-number] 0 / Adrenergic beta-Antagonists; 9Y8NXQ24VQ / Propranolol
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96. Altomare I, Desman G, Aledort LM: Echinocytosis--an unusual manifestation of hemangioma. Am J Hematol; 2006 Jul;81(7):532-4
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  • [Title] Echinocytosis--an unusual manifestation of hemangioma.
  • The case of a 21 year-old female with echinocytosis and a littoral cell hemangioma is reported.
  • A CT-recognized splenic mass led to splenectomy and a benign hemangioma was found.
  • This is the first case reported in the literature of echinocytosis as a consequence of a hemangioma.
  • [MeSH-major] Erythrocytes, Abnormal. Hemangioma / pathology. Spleen / pathology. Splenic Neoplasms / pathology

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  • (PMID = 16755560.001).
  • [ISSN] 0361-8609
  • [Journal-full-title] American journal of hematology
  • [ISO-abbreviation] Am. J. Hematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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97. Madge SN, Simon S, Abidin Z, Ghabrial R, Davis G, McNab A, Selva D: Primary orbital intraosseous hemangioma. Ophthal Plast Reconstr Surg; 2009 Jan-Feb;25(1):37-41
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  • [Title] Primary orbital intraosseous hemangioma.
  • PURPOSE: Primary orbital intraosseous hemangioma represents a rare, histopathologically benign, vascular tumor of the bony orbit.
  • The authors present 4 new cases of the disease and review the relevant literature.
  • METHODS: Retrospective, multicenter case note analysis of 4 patients with histopathologically confirmed primary orbital intraosseous hemangioma and a systematic review of the English-language literature.
  • RESULTS: Four new cases of cavernous haemangiomata are presented with varying clinical manifestations, radiologic appearances, and treatments.
  • Histopathologically, the lesions were cavernous in 80%, capillary in 17%, and mixed in 3%; the capillary subtype seemed to be associated with more aggressive disease.
  • CONCLUSIONS: Primary orbital intraosseous hemangioma is a rare vascular tumor that typically presents with a mass effect in the orbits of patients in the fourth and fifth decades of life.
  • Preoperatively, it is important to be cognizant of the possible diagnosis as surgery can be complicated by life-threatening hemorrhage.
  • [MeSH-major] Hemangioma, Capillary / pathology. Hemangioma, Cavernous / pathology. Orbital Neoplasms / pathology

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  • (PMID = 19273921.001).
  • [ISSN] 1537-2677
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Multicenter Study
  • [Publication-country] United States
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98. Turowski C, Feist H, Alzen G, Glüer S, Petersen C: Conversion of a neonatal hepatic hemangioma to focal nodular hyperplasia. Pathol Int; 2009 Apr;59(4):251-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Conversion of a neonatal hepatic hemangioma to focal nodular hyperplasia.
  • Hepatic hemangioma and focal nodular hyperplasia are both frequently observed benign lesions of the liver.
  • Whereas hepatic hemangioma is the most frequent benign liver tumor in children, focal nodular hyperplasia occurs predominantly in adult patients.
  • We report on a 6-month-old child with a continuously shrinking hepatic hemangioma after interventional therapy and a growing hepatic mass 5 years later, which emerged as focal nodular hyperplasia at the site of the former hemangioma.
  • [MeSH-major] Focal Nodular Hyperplasia / pathology. Hemangioma / pathology. Liver Neoplasms / pathology

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  • (PMID = 19351369.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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99. Ito K, Taira K, Arii S: Intrahepatic bile duct dilatation with a liver cyst and hemangioma: report of a case. Surg Today; 2009;39(3):256-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intrahepatic bile duct dilatation with a liver cyst and hemangioma: report of a case.
  • We report a case of intrahepatic bile duct dilatation with a liver cyst and hemangioma.
  • A 58-year-old woman was referred for investigation of a cystic lesion and peripheral intrahepatic bile duct dilatation in the left lateral segment of the liver.
  • Microscopically, the cyst was lined with a single layer of flattened epithelial cells and a spongy tumor was diagnosed as cavernous hemangioma, which compressed the bile duct.
  • The histopathological diagnosis was biliary stenosis associated with cavernous hemangioma of the liver.
  • Invasive surgery may be avoided by awareness of this unusual benign pathology.
  • [MeSH-major] Bile Ducts, Intrahepatic / pathology. Cysts / pathology. Hemangioma / pathology. Liver Diseases / pathology. Liver Neoplasms / pathology


100. Di Lorenzo S, Corradino B, Cordova A, Moschella F: Unexpected ulnar nerve schwannoma. The reasonable risk of misdiagnosis. Acta Chir Plast; 2007;49(3):77-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The mass was associated with mild and sporadic discomfort due to the mass size; the clinical neurological examination was not conclusive, with Tinel's sign negative; surgery confirmed the nervous origin of the tumor and the histopathologic exam confirmed the diagnosis of schwannoma.
  • These tumors are difficult to diagnose clinically and have often been confused with other benign tumors such as lipomas, hemangiomas, synovial cysts, neurofibromas, etc.
  • Clinical care is important to prevent, during the surgery, the unfortunate resection of the nerve; all too frequently this diagnosis is made intraoperatively or postoperatively with the potential to compromise the outcome of the treatment.
  • An appropriate degree of awareness is necessary for the inclusion of peripheral nerve tumors as a differential diagnosis of an upper extremity mass.

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  • (PMID = 18051588.001).
  • [ISSN] 0001-5423
  • [Journal-full-title] Acta chirurgiae plasticae
  • [ISO-abbreviation] Acta Chir Plast
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Czech Republic
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