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1. Westphal FL, Lima LC, Santana LC, Netto JC, Amaral VC, Silva Mdos S: Castleman's disease associated with follicular dendritic cell sarcoma and myasthenia gravis. J Bras Pneumol; 2010 Nov-Dec;36(6):819-23
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Castleman's disease associated with follicular dendritic cell sarcoma and myasthenia gravis.
  • Castleman's disease is an atypical lymphoproliferative disorder of unknown etiology, which might be associated with various clinical conditions, including autoimmune diseases and malignant neoplasms.
  • After the resection of the mediastinal tumor, the histopathological examination revealed hyaline vascular-type Castleman's disease, complicated by follicular dendritic cell sarcoma.
  • At this writing, the patient was being treated with an anticholinesterase agent and corticosteroids for the control of myasthenia gravis.
  • [MeSH-major] Dendritic Cell Sarcoma, Follicular / complications. Giant Lymph Node Hyperplasia / complications. Myasthenia Gravis / diagnosis

  • Genetic Alliance. consumer health - Castleman's Disease.
  • Genetic Alliance. consumer health - Myasthenia gravis.
  • MedlinePlus Health Information. consumer health - Myasthenia Gravis.
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  • (PMID = 21225186.001).
  • [ISSN] 1806-3756
  • [Journal-full-title] Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia
  • [ISO-abbreviation] J Bras Pneumol
  • [Language] eng; por
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Brazil
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2. Al Otaibi T, Al Sagheir A, Ludwin D, Meyer R: Post renal transplant Castleman's disease resolved after graft nephrectomy: a case report. Transplant Proc; 2007 May;39(4):1276-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Post renal transplant Castleman's disease resolved after graft nephrectomy: a case report.
  • Angiofollicular lymphoid hyperplasia (Castleman's disease) is a lymphoproliferative process thought to be mediated by overexpression of II interleukin-6.
  • Castleman's disease has two variants: Castleman's disease has two variants: Hyaline vascular type and plasma cell variant (multicentric Castleman's disease).
  • The hyaline vascular type tends to be localized, and the plasma cell variant shows more systematic signs and carriers a worse clinical prognosis.
  • Castleman's disease is associated with B-cell lymphoma, Kaposi sarcoma, Human herpes virus 8 (HHV-8), and Epstein-Barr virus.
  • Castleman's disease have been described thrice post kidney transplant.
  • In this report, we document the course of a renal recipient who developed the plasma cell variant of Castleman's disease at 16 months after failure of his allograft and return to dialysis.
  • To our knowledge, this is the first case where the disease manifestations disappeared after graft removal.
  • Our patient experienced chronic renal allograft rejection which may have driven all the systematic manifestations of multicentric castleman's disease and possibly reactivated a latent HHV-8 infection.
  • In this case immunohistochemical testing for HHV-8 was not available to prove a role for this agent.
  • [MeSH-major] Giant Lymph Node Hyperplasia / diagnosis. Kidney Transplantation / adverse effects
  • [MeSH-minor] Humans. Immunosuppressive Agents / therapeutic use. Lymph Nodes / pathology. Male. Middle Aged. Nephrectomy. Renal Dialysis. Reoperation






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