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1. Perez EG, Paranaíba LR, Bonan PR, Orsi Júnior JM, Oliveira AM, Martelli Júnior H: [Tuberous sclerosis: evaluation of myofibroblasts in cutaneous angiofibromas - case report]. An Bras Dermatol; 2010 Jan-Feb;85(1):84-8
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  • [Title] [Tuberous sclerosis: evaluation of myofibroblasts in cutaneous angiofibromas - case report].
  • [Transliterated title] Esclerose tuberosa: avaliação de miofibroblastos em angiofibromas cutâneos - relato de caso.
  • Tuberous sclerosis is a rare autosomal dominant disorder.
  • The objective of this study is to describe clinical and histopathological characteristics of tuberous sclerosis and to conduct an immunohistochemical evaluation of myofibroblasts in cutaneous angiofibromas present in this condition.
  • Since alpha-SMA is a specific marker for myofibroblasts, this result suggests that myofibroblasts are not involved in cutaneous angiofibromas present in the tuberous sclerosis case reported.
  • [MeSH-major] Angiofibroma / complications. Angiofibroma / pathology. Fibroblasts / pathology. Skin Neoplasms / complications. Skin Neoplasms / pathology. Tuberous Sclerosis / complications

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  • (PMID = 20464093.001).
  • [ISSN] 1806-4841
  • [Journal-full-title] Anais brasileiros de dermatologia
  • [ISO-abbreviation] An Bras Dermatol
  • [Language] por
  • [Publication-type] Case Reports; English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Brazil
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2. Rosón E, Flórez A, Feal C, De La Torre C, García-Doval I, Abalde T, Cruces M: Progressive nodular histiocytoma associated with thrombocytopenia with absent radii (TAR syndrome) and angiofibromas. Acta Derm Venereol; 2006;86(4):348-50
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  • [Title] Progressive nodular histiocytoma associated with thrombocytopenia with absent radii (TAR syndrome) and angiofibromas.
  • Moreover, the patient had numerous smooth erythematous papules on her chin and around her nose, which were diagnosed histologically as angiofibromas.
  • To our knowledge progressive nodular histiocytoma has not been reported previously associated either with TAR syndrome or with angiofibromas.
  • [MeSH-major] Angiofibroma / complications. Ectromelia / complications. Histiocytoma / pathology. Radius / abnormalities. Skin Diseases / pathology. Thrombocytopenia / complications

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  • (PMID = 16874423.001).
  • [ISSN] 0001-5555
  • [Journal-full-title] Acta dermato-venereologica
  • [ISO-abbreviation] Acta Derm. Venereol.
  • [Language] eng
  • [Databank-accession-numbers] OMIM/ 274000
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Norway
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3. Zeller S, Marx SJ, Lungu AO, Cowen EW, Turner ML: Multiple angiofibromas and collagenomas in a 45-year-old man with recurrent nephrolithiasis, fatigue, and vision loss. J Am Acad Dermatol; 2009 Aug;61(2):319-22
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  • [Title] Multiple angiofibromas and collagenomas in a 45-year-old man with recurrent nephrolithiasis, fatigue, and vision loss.
  • [MeSH-major] Angiofibroma / diagnosis. Multiple Endocrine Neoplasia Type 1 / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adrenalectomy / methods. Biopsy, Needle. Collagen Diseases / complications. Collagen Diseases / diagnosis. Fatigue / complications. Fatigue / diagnosis. Follow-Up Studies. Humans. Immunohistochemistry. Male. Middle Aged. Nephrolithiasis / complications. Nephrolithiasis / diagnosis. Pancreatectomy. Recurrence. Risk Assessment. Severity of Illness Index. Splenectomy / methods. Vision Disorders / complications. Vision Disorders / diagnosis

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  • (PMID = 19615541.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z99 CA999999
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS135687; NLM/ PMC2744374
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4. Ngan BY, Forte V, Campisi P: Molecular angiogenic signaling in angiofibromas after embolization: implications for therapy. Arch Otolaryngol Head Neck Surg; 2008 Nov;134(11):1170-6
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  • [Title] Molecular angiogenic signaling in angiofibromas after embolization: implications for therapy.
  • OBJECTIVES: To examine (1) the molecular angiogenic relationship between endothelial and stromal cells of angiofibromas and how this may elucidate the pathogenesis of angiofibromas and (2) the effects of embolization on the expression of angiotrophic factors and proapoptotic and antiapoptotic factors within the tumor.
  • DESIGN: The expression of mesenchymal and endothelial stem/progenitor cell-associated proteins (MECAPs) such as proangiogenic cytokine vascular endothelial growth factor (VEGF), VEGF receptors (VEGFR1, VEGFR2, and VEGFR3), angiopoietin receptors (Tie-1 and Tie-2), and stem cell subset marker CD133 was assessed by immunohistological staining in 7 embolized angiofibroma specimens.
  • Expression of proapoptotic Bax, antiapoptotic Bcl-2 and Bcl-xL, nuclear proliferation protein MiB-1, and hypoxia-inducible factor 1alpha (Hif-1alpha) in peri-ischemic areas of the embolized angiofibromas was also assessed.
  • PATIENTS: Seven patients (identified from medical records, January 1, 2001, through December 31, 2005) who were diagnosed as having juvenile angiofibroma and who underwent surgical treatment.
  • RESULTS: All angiofibroma specimens expressed the stem cell subset marker CD133 and MECAPs except VEGFR3 (a few cases).
  • Specific angiogenesis blockers may represent a novel treatment strategy for angiofibromas.
  • [MeSH-major] Angiofibroma / genetics. Angiofibroma / therapy. Biomarkers, Tumor / genetics. Embolization, Therapeutic. Neoplasm Proteins / genetics. Otorhinolaryngologic Neoplasms / genetics. Otorhinolaryngologic Neoplasms / therapy. Signal Transduction / genetics

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  • (PMID = 19015446.001).
  • [ISSN] 1538-361X
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Angiogenesis Inducing Agents; 0 / Biomarkers, Tumor; 0 / HIF1A protein, human; 0 / Hypoxia-Inducible Factor 1, alpha Subunit; 0 / Neoplasm Proteins; 0 / Vascular Endothelial Growth Factor A
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5. Li Z, Lin G, He L, Yi Z: [Perioperative managements of huge lobulated nasopharyngeal angiofibromas with intracranial extensions]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2008 Jul;22(14):639-41
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  • [Title] [Perioperative managements of huge lobulated nasopharyngeal angiofibromas with intracranial extensions].
  • OBJECTIVE: To summarize our experience of successful and failed management in 8 huge lobulated nasopharyngeal angiofibromas with intracranial extensions, and introduce some key points of perioperative treatments.
  • [MeSH-major] Angiofibroma / surgery. Brain Neoplasms / surgery. Nasopharyngeal Neoplasms / surgery

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  • (PMID = 18841793.001).
  • [ISSN] 1001-1781
  • [Journal-full-title] Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
  • [ISO-abbreviation] Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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6. Wee SA, Fangman B: Tuberous sclerosis. Dermatol Online J; 2007;13(1):22
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  • Histopathologic examination was consistent with angiofibromas.
  • [MeSH-minor] Biopsy. Diagnosis, Differential. Female. Frontal Bone / radiography. Genetic Predisposition to Disease. Humans. Lacrimal Apparatus / pathology. Middle Aged. Skin / pathology. Tomography, X-Ray Computed

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  • (PMID = 17511955.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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7. Elifritz J, Krishnan RS, Donnelly H: Numerous fibrous papules of the face unassociated with any genodermatosis. Dermatol Online J; 2007;13(4):12

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Numerous fibrous papules of the face unassociated with any genodermatosis.
  • Numerous angiofibromas on the face are commonly associated with tuberous sclerosis or multiple endocrine neoplasia type 1.
  • We present a healthy 66-year-old female with numerous facial angiofibromas, without evidence of tuberous sclerosis, multiple endocrine neoplasia type 1, or any of the less common syndromes associated with many angiofibromas on the face.
  • To our knowledge, there have been no previously reported cases of patients with numerous facial angiofibromas who did not have an associated genodermatosis.
  • [MeSH-major] Angiofibroma / etiology. Facial Neoplasms / etiology
  • [MeSH-minor] Aged. Face. Female. Humans. Skin / pathology. Skin Diseases, Genetic

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  • (PMID = 18319009.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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8. Pires CF, Anunciação GM, De Sousa WL, Santos BM, Anunciação FA, Pires AF, Pires LF: [Tuberous sclerosis in childhood]. Dermatol Online J; 2008;14(9):14
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  • Tuberous sclerosis is an autosomal dominant disease that results from mutations in one of two tumor suppressor genes, TSC1 and TSC2.
  • We are reporting a two-year-old girl who presented with hypopigmented macules (ash leaf) in the skin and small erythematous facial papules (angiofibromas).
  • Although the signs of tuberous sclerosis were specifically looked for in this patient because of her mother, subtle angiofibromas in a young child can be easily missed.
  • [MeSH-major] Angiofibroma / etiology. Facial Neoplasms / etiology. Tuberous Sclerosis / diagnosis

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  • (PMID = 19061596.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] por
  • [Publication-type] Case Reports; English Abstract; Letter
  • [Publication-country] United States
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9. Schepis C, Siragusa M: Cryosurgery: an easy and cheap therapy for facial angiofibromas in tuberous sclerosis. Eur J Dermatol; 2010 Jul-Aug;20(4):506-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cryosurgery: an easy and cheap therapy for facial angiofibromas in tuberous sclerosis.
  • [MeSH-major] Angiofibroma / surgery. Cryosurgery / methods. Facial Neoplasms / surgery. Tuberous Sclerosis / surgery

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  • (PMID = 20403796.001).
  • [ISSN] 1167-1122
  • [Journal-full-title] European journal of dermatology : EJD
  • [ISO-abbreviation] Eur J Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] France
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10. Wu A, Mowry S, Vinuela F, Abemayor E, Wang M: Bilateral vascular supply in juvenile nasopharyngeal angiofibromas. Laryngoscope; 2010;120 Suppl 4:S249

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bilateral vascular supply in juvenile nasopharyngeal angiofibromas.
  • [MeSH-major] Angiofibroma / blood supply. Nasopharyngeal Neoplasms / blood supply

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  • (PMID = 21225846.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
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11. Türkmen M, Ertam I, Unal I, Dereli T: Facial angiofibromas of tuberous sclerosis: successful treatment with podophyllin. J Eur Acad Dermatol Venereol; 2009 Jun;23(6):713-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Facial angiofibromas of tuberous sclerosis: successful treatment with podophyllin.
  • [MeSH-major] Angiofibroma / drug therapy. Face. Podophyllin / therapeutic use. Tuberous Sclerosis / complications

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  • (PMID = 18785889.001).
  • [ISSN] 1468-3083
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 9000-55-9 / Podophyllin
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12. Weiss ET, Geronemus RG: New technique using combined pulsed dye laser and fractional resurfacing for treating facial angiofibromas in tuberous sclerosis. Lasers Surg Med; 2010 Jul;42(5):357-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] New technique using combined pulsed dye laser and fractional resurfacing for treating facial angiofibromas in tuberous sclerosis.
  • BACKGROUND AND OBJECTIVE: Tuberous sclerosis (TS) is a well-described genetic disorder that is classically associated with up to hundreds of facial angiofibromas.
  • STUDY DESIGN/PATIENTS AND METHODS: We report a combinatorial technique for treating the angiofibromas of TS.
  • RESULTS: In all presented cases, improvement in the number and appearance of facial angiofibromas and erythema is noted.
  • CONCLUSION: The technique of electrosurgery, pulsed-dye laser treatment, and AFR represents a new and safe therapeutic option for treating facial angiofibromas associated with TS.
  • [MeSH-major] Angiofibroma / etiology. Angiofibroma / surgery. Facial Neoplasms / etiology. Facial Neoplasms / surgery. Laser Therapy / methods. Lasers, Dye / therapeutic use. Skin Neoplasms / etiology. Skin Neoplasms / surgery. Tuberous Sclerosis / complications

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  • (PMID = 20583249.001).
  • [ISSN] 1096-9101
  • [Journal-full-title] Lasers in surgery and medicine
  • [ISO-abbreviation] Lasers Surg Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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13. Hunter AG, Nezarati MM, Velsher L: Absence of signs of systemic involvement in four patients with bilateral multiple facial angiofibromas. Am J Med Genet A; 2010 Mar;152A(3):657-64
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Absence of signs of systemic involvement in four patients with bilateral multiple facial angiofibromas.
  • Facial angiofibromas are a major diagnostic sign for tuberous sclerosis (TS) and MEN1, and the former is probably the first disease to be considered by a geneticist when such lesions are found.
  • Early onset facial angiofibromas that are not associated with any other systemic sign appear to be unusual, and their occurrence can leave the clinician with some uncertainty as to their significance, as well as how to proceed.
  • In this article we describe four patients with what appear to be isolated, bilateral facial angiofibromas.
  • We discuss the significance of these lesions with respect to the conditions in which they have been seen, review prior reports of apparently isolated angiofibromas, and provide some rough calculations as to how likely it would be for an underlying systemic condition to be overlooked after different levels of investigation have been performed.
  • [MeSH-major] Angiofibroma / pathology. Facial Neoplasms / pathology. Neoplasms, Multiple Primary / pathology

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  • [Copyright] (c) 2010 Wiley-Liss, Inc.
  • (PMID = 20186817.001).
  • [ISSN] 1552-4833
  • [Journal-full-title] American journal of medical genetics. Part A
  • [ISO-abbreviation] Am. J. Med. Genet. A
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 38
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14. Schick B, Veldung B, Wemmert S, Jung V, Montenarh M, Meese E, Urbschat S: p53 and Her-2/neu in juvenile angiofibromas. Oncol Rep; 2005 Mar;13(3):453-7
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  • [Title] p53 and Her-2/neu in juvenile angiofibromas.
  • The pathogenesis of juvenile angiofibroma (JA) remains unsolved.
  • [MeSH-major] Angiofibroma / genetics. Angiofibroma / physiopathology. Chromosomes, Human, Pair 17. Gene Expression Profiling. Receptor, ErbB-2 / biosynthesis. Tumor Suppressor Protein p53 / biosynthesis

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  • (PMID = 15706416.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / RNA, Messenger; 0 / Tumor Suppressor Protein p53; EC 2.7.10.1 / Receptor, ErbB-2
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15. Celik B, Erisen L, Saraydaroglu O, Coskun H: Atypical angiofibromas: a report of four cases. Int J Pediatr Otorhinolaryngol; 2005 Mar;69(3):415-21
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  • [Title] Atypical angiofibromas: a report of four cases.
  • In this study, our four patients with angiofibroma with various atypical features are presented.
  • 14 patients, diagnosed and treated for angiofibroma in the Otorhinolaryngology Department of Faculty of Medicine in Uludag University between January 1992 and December 2003, have been evaluated.
  • Angiofibromas presenting with at least one of the following criteria such as origin or location other than nasopharynx, presenting complaints other than nasal obstruction or epistaxis, aged younger than seven or older than 25, female sex, atypical histopathology and multifocalitiy were considered as "atypical".
  • Four of 14 angiofibromas (28.5%), which were diagnosed and treated in our clinic, had atypical features.
  • The patients, who have different characteristics other than classical angiofibromas, may be called "Atypical Angiofibroma (AAF)", under the scope of the related literature and our experience.
  • [MeSH-major] Angiofibroma / pathology. Cheek / pathology. Nasopharyngeal Neoplasms / pathology. Nose Neoplasms / pathology. Soft Tissue Neoplasms / pathology. Tonsillar Neoplasms / pathology. Turbinates / pathology

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  • (PMID = 15733604.001).
  • [ISSN] 0165-5876
  • [Journal-full-title] International journal of pediatric otorhinolaryngology
  • [ISO-abbreviation] Int. J. Pediatr. Otorhinolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Ireland
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16. Wagner A, Svendsen P, von Buchwald C, Kirkegaard J: [Treatment of juvenile angiofibromas]. Ugeskr Laeger; 2005 Nov 21;167(47):4482

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Treatment of juvenile angiofibromas].
  • [Transliterated title] Behandling af juvenile angiofibromer.
  • [MeSH-major] Angiofibroma / surgery. Nasopharyngeal Neoplasms / surgery

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  • [CommentOn] Ugeskr Laeger. 2005 Aug 22;167(34):3163-6 [16117914.001]
  • [CommentOn] Ugeskr Laeger. 2005 Aug 22;167(34):3167-9 [16117915.001]
  • (PMID = 16305784.001).
  • [ISSN] 1603-6824
  • [Journal-full-title] Ugeskrift for laeger
  • [ISO-abbreviation] Ugeskr. Laeg.
  • [Language] dan
  • [Publication-type] Comment; Letter
  • [Publication-country] Denmark
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17. Schick B, Wemmert S, Bechtel U, Nicolai P, Hofmann T, Golabek W, Urbschat S: Comprehensive genomic analysis identifies MDM2 and AURKA as novel amplified genes in juvenile angiofibromas. Head Neck; 2007 May;29(5):479-87
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  • [Title] Comprehensive genomic analysis identifies MDM2 and AURKA as novel amplified genes in juvenile angiofibromas.
  • BACKGROUND: Frequent beta-catenin mutations have been detected in juvenile angiofibromas, but the tumor pathogenesis remains unknown.
  • CONCLUSION: Metaphase-CGH results confirmed numerous chromosomal aberrations in juvenile angiofibromas.
  • AURKA and MDM2 were identified as interesting novel amplified genes in juvenile angiofibromas.
  • [MeSH-major] Angiofibroma / genetics. Chromosome Aberrations. Head and Neck Neoplasms / genetics. Protein-Serine-Threonine Kinases / genetics. Proto-Oncogene Proteins c-mdm2 / genetics

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  • [Copyright] (c) 2006 Wiley Periodicals, Inc.
  • (PMID = 17120309.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.11.1 / AURKA protein, human; EC 2.7.11.1 / Aurora Kinase A; EC 2.7.11.1 / Aurora Kinases; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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18. Tyagi I, Syal R, Goyal A: Recurrent and residual juvenile angiofibromas. J Laryngol Otol; 2007 May;121(5):460-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recurrent and residual juvenile angiofibromas.
  • INTRODUCTION: In the surgical management of juvenile nasopharyngeal angiofibromas the possibility of recurrences and residual tumours is always there.
  • This study was undertaken to predict the prognostic factors determining recurrence of juvenile nasopharyngeal angiofibroma and to find out the usual sites of these tumours.
  • MATERIAL AND METHODS: The medical records of 95 patients with histologically proven juvenile nasopharyngeal angiofibroma were reviewed retrospectively.
  • RESULTS: Complete removal of the juvenile nasopharyngeal angiofibroma was achieved in 78 (82 per cent) of the cases in a single operation.
  • CONCLUSIONS: Extensions into the pterygoid fossa and basisphenoid, erosion of the clivus, intracranial extensions medial to the cavernous sinus, invasion of the sphenoid diploe through a widened pterygoid canal, feeders from the internal carotid artery, a young age and a residual tumour were risk factors found associated with recurrence of juvenile nasopharyngeal angiofibroma.
  • [MeSH-major] Angiofibroma / surgery. Nasopharyngeal Neoplasms / surgery. Neoplasm Recurrence, Local

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  • (PMID = 17210091.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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19. Haemel AK, O'Brian AL, Teng JM: Topical rapamycin: a novel approach to facial angiofibromas in tuberous sclerosis. Arch Dermatol; 2010 Jul;146(7):715-8
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  • [Title] Topical rapamycin: a novel approach to facial angiofibromas in tuberous sclerosis.
  • [MeSH-major] Angiofibroma / drug therapy. Facial Neoplasms / drug therapy. Immunosuppressive Agents / administration & dosage. Sirolimus / administration & dosage. Tuberous Sclerosis / complications

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  • [CommentIn] JAMA Dermatol. 2013 Feb;149(2):203 [23426474.001]
  • [CommentIn] Arch Dermatol. 2011 Sep;147(9):1116-7 [21931059.001]
  • (PMID = 20644030.001).
  • [ISSN] 1538-3652
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Immunosuppressive Agents; W36ZG6FT64 / Sirolimus
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20. Bordel-Gómez MT, Monteagudo-Sánchez B, Alvarez-Fernández JC: [Multiple unilateral facial angiofibromas: description of a new case]. Actas Dermosifiliogr; 2008 Dec;99(10):824-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Multiple unilateral facial angiofibromas: description of a new case].
  • [Transliterated title] Angiofibromas faciales múltiples unilaterales: aportación de un nuevo caso.
  • [MeSH-major] Angiofibroma / genetics. Facial Neoplasms / genetics. Tuberous Sclerosis / diagnosis

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  • (PMID = 19091228.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; Letter; Review
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Calcium Phosphates; 0 / Glycopeptides; 87139-86-4 / Immunoferon
  • [Number-of-references] 16
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21. Coutinho-Camillo CM, Brentani MM, Nagai MA: Genetic alterations in juvenile nasopharyngeal angiofibromas. Head Neck; 2008 Mar;30(3):390-400

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Genetic alterations in juvenile nasopharyngeal angiofibromas.
  • Juvenile nasopharyngeal angiofibroma (JNA) is a rare benign neoplasm of the nasopharynx that accounts for 0.5% of all head and neck tumors.
  • Although histologically benign in appearance, JNAs are locally aggressive and destructive, spreading from the nasal cavity to the nasopharynx, paranasal sinuses, and orbit skull base with intracranial extension.
  • [MeSH-major] Angiofibroma / genetics. Nasopharyngeal Neoplasms / genetics

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  • [Copyright] (c) 2008 Wiley Periodicals, Inc. Head Neck, 2008.
  • (PMID = 18228521.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Intercellular Signaling Peptides and Proteins; 0 / RNA, Messenger; 0 / Receptors, Steroid; 0 / beta Catenin; EC 2.5.1.18 / Glutathione Transferase
  • [Number-of-references] 103
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22. Camprubí M, Balaguer A, Azon Masoliver A, Jiménez-Feijoo R, Escribano Subias J: Unilateral facial angiofibromas; a review of the literature. Pediatr Dermatol; 2006 May-Jun;23(3):303-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Unilateral facial angiofibromas; a review of the literature.
  • [MeSH-major] Angiofibroma / pathology. Facial Neoplasms / pathology. Skin Neoplasms / pathology

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  • (PMID = 16780491.001).
  • [ISSN] 0736-8046
  • [Journal-full-title] Pediatric dermatology
  • [ISO-abbreviation] Pediatr Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Letter; Review
  • [Publication-country] United States
  • [Number-of-references] 11
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23. La Placa M, Gibellini D, Bianchi T, Patrizi A: Overexpression of MLH-1 and psoriasin genes in cutaneous angiofibromas from tuberous sclerosis complex patients. J Cutan Pathol; 2006 Sep;33(9):608-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Overexpression of MLH-1 and psoriasin genes in cutaneous angiofibromas from tuberous sclerosis complex patients.
  • BACKGROUND: Tuberous sclerosis complex (TSC) is associated with mutations in two likely tumor-suppressor genes (TSC1 and TSC2) and characterized by the development of tumor-like growths (angiofibromas) in a variety of tissues and organs, particularly brain and skin.
  • RESULTS: The results obtained by the microarray technology in one hamartoma specimen, confirmed by the RT-PCR results obtained in the same material and in five other hamartoma specimens, demonstrated that TSC-related angiofibromas exhibit significant mRNA overexpression of two genes, represented by MLH-1 and psoriasin.
  • CONCLUSIONS: The overexpression of MLH-1, which codes for a DNA mismatch repair protein, and psoriasin, which codes for a specific chemoattractant factor for CD4+ T cells, implicated in the pathogenesis of inflammatory skin disease, and expressed in excess during abnormal pathways of cell growth, may shed light on the pathogenesis of the proliferative skin lesion.
  • [MeSH-major] Angiofibroma / genetics. Calcium-Binding Proteins / genetics. Carrier Proteins / genetics. Nuclear Proteins / genetics. Skin Neoplasms / genetics. Tuberous Sclerosis / genetics

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  • (PMID = 16965334.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Biomarkers, Tumor; 0 / Calcium-Binding Proteins; 0 / Carrier Proteins; 0 / MLH1 protein, human; 0 / Nuclear Proteins; 0 / RNA, Messenger; 0 / S100 Proteins; 0 / S100A7 protein, human
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24. Chen MK, Tsai YL, Lee KW, Chang CC: Strictly endoscopic and harmonic scalpel-assisted surgery of nasopharyngeal angiofibromas: eligible for advanced stage tumors. Acta Otolaryngol; 2006 Dec;126(12):1321-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Strictly endoscopic and harmonic scalpel-assisted surgery of nasopharyngeal angiofibromas: eligible for advanced stage tumors.
  • CONCLUSIONS: With the assistance of the harmonic scalpel, endoscopic surgery is eligible for advanced nasopharyngeal angiofibromas with skull base or infratemoporal fossa invasion.
  • OBJECTIVES: To evaluate the safety and efficacy of strictly endoscopic removal of early and advanced stage nasopharyngeal angiofibromas.
  • Eight operations for seven consecutive patients presenting with a nasopharyngeal angiofibroma were performed via minimally invasive endoscopic resection by a single surgeon (M.K.C.).
  • [MeSH-major] Angiofibroma / surgery. Endoscopy. Nasopharyngeal Neoplasms / surgery. Ultrasonic Therapy / instrumentation

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  • (PMID = 17101595.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Norway
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25. Hofmann T, Bernal-Sprekelsen M, Koele W, Reittner P, Klein E, Stammberger H: Endoscopic resection of juvenile angiofibromas--long term results. Rhinology; 2005 Dec;43(4):282-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Endoscopic resection of juvenile angiofibromas--long term results.
  • OBJECTIVE: To evaluate the long term outcome after endoscopic endonasal resection of juvenile nasopharyngeal angiofibromas (JNA).
  • METHODS: Retrospective study of a series of 21 consecutive patients undergoing endoscopic resection of JNA (type I - IIIa according to Fisch) at two Hospital Centers between 1993 and 2002.
  • RESULTS: Fifteen patients (71.4%) were free of disease after one endoscopic resection.
  • CONCLUSIONS: Resection of nasopharyngeal angiofibromas type I-IIIa can be safely achieved endoscopically.
  • [MeSH-major] Angiofibroma / surgery. Endoscopy / methods. Nasopharyngeal Neoplasms / surgery

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  • (PMID = 16405273.001).
  • [ISSN] 0300-0729
  • [Journal-full-title] Rhinology
  • [ISO-abbreviation] Rhinology
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] Netherlands
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26. Gramann M, Wendler O, Haeberle L, Schick B: Prominent collagen type VI expression in juvenile angiofibromas. Histochem Cell Biol; 2009 Jan;131(1):155-64

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prominent collagen type VI expression in juvenile angiofibromas.
  • Although, juvenile angiofibromas (JAs) often exhibit an aggressive growth pattern, the collagen type VI expression of this fibrovascular tumour has not been addressed so far.
  • [MeSH-major] Angiofibroma / metabolism. Collagen Type VI / metabolism

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  • [Cites] Exp Cell Res. 1993 Nov;209(1):103-17 [8223995.001]
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  • (PMID = 18797915.001).
  • [ISSN] 1432-119X
  • [Journal-full-title] Histochemistry and cell biology
  • [ISO-abbreviation] Histochem. Cell Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Collagen Type VI
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27. Schaffer JV, Gohara MA, McNiff JM, Aasi SZ, Dvoretzky I: Multiple facial angiofibromas: a cutaneous manifestation of Birt-Hogg-Dubé syndrome. J Am Acad Dermatol; 2005 Aug;53(2 Suppl 1):S108-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multiple facial angiofibromas: a cutaneous manifestation of Birt-Hogg-Dubé syndrome.
  • This report describes multiple facial angiofibromas as the predominant initial manifestation of BHDS.
  • The patient had a total of 41 facial papules removed via shave excision, initially for diagnostic and then for therapeutic purposes; histologic evaluation revealed diagnostic features of angiofibroma in 39 lesions and fibrofolliculoma in only 2.
  • BHDS should be considered, along with tuberous sclerosis and multiple endocrine neoplasia type 1, in the differential diagnosis of multiple facial angiofibromas, particularly when onset is in adulthood.
  • [MeSH-major] Angiofibroma / diagnosis. Diseases in Twins / diagnosis. Facial Neoplasms / diagnosis. Neoplastic Syndromes, Hereditary / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 16021156.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / FLCN protein, human; 0 / Proteins; 0 / Proto-Oncogene Proteins; 0 / Tumor Suppressor Proteins
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28. Weinberger CH, Endrizzi B, Hook KP, Lee PK: Treatment of angiofibromas of tuberous sclerosis with 5-aminolevulinic acid blue light photodynamic therapy followed by immediate pulsed dye laser. Dermatol Surg; 2009 Nov;35(11):1849-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Treatment of angiofibromas of tuberous sclerosis with 5-aminolevulinic acid blue light photodynamic therapy followed by immediate pulsed dye laser.
  • [MeSH-major] Aminolevulinic Acid / administration & dosage. Angiofibroma / therapy. Facial Neoplasms / therapy. Lasers, Dye. Low-Level Light Therapy. Photochemotherapy. Photosensitizing Agents / administration & dosage. Skin Neoplasms / therapy. Tuberous Sclerosis / complications

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  • (PMID = 19682000.001).
  • [ISSN] 1524-4725
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Photosensitizing Agents; 88755TAZ87 / Aminolevulinic Acid
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29. Roche PH, Paris J, Régis J, Moulin G, Zanaret M, Thomassin JM, Pellet W: Management of invasive juvenile nasopharyngeal angiofibromas: the role of a multimodality approach. Neurosurgery; 2007 Oct;61(4):768-77; discussion 777

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Management of invasive juvenile nasopharyngeal angiofibromas: the role of a multimodality approach.
  • OBJECTIVE: Juvenile nasopharyngeal angiofibromas involving the cranial base and intracranial compartment are challenging tumors.
  • We reviewed our experience of these tumors and analyzed the efficacy of a multimodality management.
  • METHODS: Between 1981 and 2000, 15 extensive juvenile nasopharyngeal angiofibromas (Fisch Grade III or IV) were treated at our institution.
  • Except for one patient who was lost to follow-up at 18 months, 12 patients were free of disease and two patients were free of tumor progression.
  • CONCLUSION: Extensive juvenile nasopharyngeal angiofibromas are efficiently managed with a multimodal protocol in which preoperative embolization is followed by optimal surgical removal using various transcranial or transfacial approaches.
  • [MeSH-major] Angiofibroma / radiotherapy. Angiofibroma / surgery. Nasopharyngeal Neoplasms / radiotherapy. Nasopharyngeal Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Child. Combined Modality Therapy / methods. Disease Management. Follow-Up Studies. Humans. Neoplasm Invasiveness. Radiosurgery / methods. Retrospective Studies

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  • (PMID = 17986938.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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30. Montag AG, Tretiakova M, Richardson M: Steroid hormone receptor expression in nasopharyngeal angiofibromas. Consistent expression of estrogen receptor beta. Am J Clin Pathol; 2006 Jun;125(6):832-7
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  • [Title] Steroid hormone receptor expression in nasopharyngeal angiofibromas. Consistent expression of estrogen receptor beta.
  • Nasopharyngeal angiofibroma is an uncommon tumor arising in adolescent males, suggesting that the tumor may be hormonally responsive.
  • The recently described ss receptor for estrogen has not been analyzed in angiofibroma.
  • We analyzed 13 cases of nasal angiofibroma by immunohistochemical analysis for the presence of ARs, progesterone receptors (PR), and ER-a and ER-ss.
  • The findings confirm that nasopharyngeal angiofibromas express ER and suggest that new modulators of ER-ss activity may provide an alternative therapy for these lesions.
  • [MeSH-major] Angiofibroma / metabolism. Estrogen Receptor beta / metabolism. Nasopharyngeal Neoplasms / metabolism. Receptors, Androgen / metabolism. Receptors, Progesterone / metabolism

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  • (PMID = 16690481.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Estrogen Receptor beta; 0 / Receptors, Androgen; 0 / Receptors, Progesterone
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31. Laurent A, Wassef M, Chapot R, Wang Y, Houdart E, Feng L, Tran Ba Huy P, Merland JJ: Partition of calibrated tris-acryl gelatin microspheres in the arterial vasculature of embolized nasopharyngeal angiofibromas and paragangliomas. J Vasc Interv Radiol; 2005 Apr;16(4):507-13
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  • [Title] Partition of calibrated tris-acryl gelatin microspheres in the arterial vasculature of embolized nasopharyngeal angiofibromas and paragangliomas.
  • PURPOSE: To determine the location of calibrated tris-acryl gelatin microspheres (TGMs) in the arterial vasculature of nasopharyngeal angiofibromas (NAFs) and paragangliomas (PGs).
  • [MeSH-major] Acrylic Resins / therapeutic use. Angiofibroma / blood supply. Embolization, Therapeutic / methods. Gelatin / therapeutic use. Nasopharyngeal Neoplasms / blood supply. Paraganglioma / blood supply

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  • (PMID = 15802450.001).
  • [ISSN] 1051-0443
  • [Journal-full-title] Journal of vascular and interventional radiology : JVIR
  • [ISO-abbreviation] J Vasc Interv Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Acrylic Resins; 0 / Coloring Agents; 0 / Fluorescent Dyes; 0 / trisacryl gelatin microspheres; 9000-70-8 / Gelatin
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32. Wendler O, Schäfer R, Schick B: Mast cells and T-lymphocytes in juvenile angiofibromas. Eur Arch Otorhinolaryngol; 2007 Jul;264(7):769-75
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  • [Title] Mast cells and T-lymphocytes in juvenile angiofibromas.
  • Juvenile angiofibroma (JA) is regarded as a benign fibrovascular tumour of unknown aetiology.
  • Due to its fibrovascular architecture the fibrous and vascular tumour component have been in the focus of most studies.
  • Western blot analysis supported finding of remarkable expression of the mast cell markers tryptase and chymase in JAs and indicated for both proteins similar but also different molecular weights than being observed in NM.
  • Regarding these observations JAs are certainly not only built up by vascular cells and fibrous stroma cells.
  • [MeSH-major] Angiofibroma / pathology. CD4-Positive T-Lymphocytes / pathology. CD8-Positive T-Lymphocytes / pathology. Mast Cells / pathology. Nose Neoplasms / pathology

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  • (PMID = 17310347.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 3.4.21.39 / Chymases; EC 3.4.21.59 / Tryptases
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33. Solomon D, Isaacson G: Transoral "adenoidectomy" excision of juvenile nasopharyngeal angiofibromas. Ann Otol Rhinol Laryngol; 2007 Apr;116(4):243-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Transoral "adenoidectomy" excision of juvenile nasopharyngeal angiofibromas.
  • OBJECTIVES: We describe a minimally invasive technique for excision of selected juvenile nasopharyngeal angiofibromas (JNAs) using indirect visualization of the nasopharynx.
  • The subjects included 4 teenage boys with early-stage nasopharyngeal angiofibromas.
  • All 4 boys are free of disease.
  • [MeSH-major] Adenoidectomy / methods. Angiofibroma / surgery. Nasopharyngeal Neoplasms / surgery
  • [MeSH-minor] Adolescent. Angiography. Disease-Free Survival. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Mouth. Neoplasm Staging. Retrospective Studies. Time Factors. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 17491520.001).
  • [ISSN] 0003-4894
  • [Journal-full-title] The Annals of otology, rhinology, and laryngology
  • [ISO-abbreviation] Ann. Otol. Rhinol. Laryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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34. Schick B: [Specific aspects of juvenile angiofibromas]. HNO; 2007 Jan;55(1):17-20

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Specific aspects of juvenile angiofibromas].
  • [MeSH-major] Angiofibroma / diagnosis. Angiofibroma / therapy. Embolization, Therapeutic / methods. Nasopharyngeal Neoplasms / diagnosis. Nasopharyngeal Neoplasms / therapy. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / prevention & control

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  • (PMID = 17160660.001).
  • [ISSN] 1433-0458
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 20
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35. Pantelis A, Bootz F, Kühnel T: [Laser skin resurfacing and fibrin sealing as successful treatment for facial angiofibromas in tuberous sclerosis]. HNO; 2007 Dec;55(13):1009-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Laser skin resurfacing and fibrin sealing as successful treatment for facial angiofibromas in tuberous sclerosis].
  • Paranasal angiofibromas may cause bleeding and difficulties in nasal breathing and can stigmatise the individual.
  • [MeSH-major] Angiofibroma / therapy. Debridement / methods. Fibrin Tissue Adhesive / therapeutic use. Laser Therapy / methods. Reconstructive Surgical Procedures / methods. Skin Neoplasms / therapy. Tuberous Sclerosis / therapy


36. Belmar P, Boixeda P, Baniandrés O, Fernández-Lorente M, Arrazola JM: [Long-term follow up of angiofibromas treated with CO2 laser in 23 patients with tuberous sclerosis]. Actas Dermosifiliogr; 2005 Oct;96(8):498-503
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Long-term follow up of angiofibromas treated with CO2 laser in 23 patients with tuberous sclerosis].
  • [Transliterated title] Seguimiento a largo plazo de angiofibromas tratados con láser de CO2 en 23 pacientes con esclerosis tuberosa.
  • INTRODUCTION: Tuberous sclerosis is an autosomal dominant disease in which hamartomas form in multiple organs.
  • Cutaneous changes are one of the primary characteristics of this disease.
  • These include angiofibromas (AF), a common form of presentation that causes significant cosmetic and medical problems.
  • The aim of our study is to assess the long-term response of the treatment of angiofibromas.
  • METHODS: A retrospective study was carried out on 23 patients with angiofibromas treated with CO2 laser.
  • We classified the angiofibromas by size, initial treatment results and patients' ages (< 20 years and 20 years or older).
  • After treatment, patients were followed up for a period of six months to 10 years.
  • When we analyzed the long-term results by the size of the angiofibromas, initial result and patients' ages, we found no statistically significant differences among the different groups.
  • [MeSH-major] Angiofibroma / complications. Angiofibroma / surgery. Laser Therapy. Skin Neoplasms / complications. Skin Neoplasms / surgery. Tuberous Sclerosis / complications

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  • (PMID = 16476284.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 142M471B3J / Carbon Dioxide
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37. Chistiakova VR, Poliaev IuA, Kovshenkova IuD, Vasil'eva NI, Myl'nikov AA, Pronin AE: [Hemostatic provision of surgical treatment of juvenile angiofibromas of the skull base in children]. Vestn Otorinolaringol; 2006;(1):24-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Hemostatic provision of surgical treatment of juvenile angiofibromas of the skull base in children].
  • For three years we operated sixty two 7-16-year-old children for angiofibroma of the base of the skull.
  • Neither lethal outcomes nor complications occurred in children during removal of angiofibromas of the base of the skull.
  • [MeSH-major] Angiofibroma / surgery. Blood Loss, Surgical / prevention & control. Hemostatic Techniques. Hemostatics / therapeutic use. Postoperative Hemorrhage / prevention & control. Skull Base Neoplasms / surgery

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  • (PMID = 16482005.001).
  • [ISSN] 0042-4668
  • [Journal-full-title] Vestnik otorinolaringologii
  • [ISO-abbreviation] Vestn. Otorinolaringol.
  • [Language] rus
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Hemostatics
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38. Dere H, Ozcan KM, Ergul G, Bahar S, Ozcan I, Kulacoglu S: Extranasopharyngeal angiofibroma of the cheek. J Laryngol Otol; 2006 Feb;120(2):141-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extranasopharyngeal angiofibroma of the cheek.
  • Angiofibromas rarely localize in extranasopharyngeal sites.
  • The most common site for extranasopharyngeal angiofibromas is the maxillary sinus.
  • The ethmoid and sphenoid sinuses, nasal septum, middle and inferior turbinates, conjunctiva, molar and retromolar region, and larynx are other sites where extranasopharyngeal angiofibromas have been reported.
  • Only one case of buccal extranasopharyngeal angiofibroma has been reported to date.
  • We present a case of buccal extranasopharyngeal angiofibroma that was excised completely following embolization and we also review the literature.
  • [MeSH-major] Angiofibroma / pathology. Mouth Neoplasms / pathology. Vascular Neoplasms / pathology

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  • (PMID = 16359575.001).
  • [ISSN] 0022-2151
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 13
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39. Nomura K, Shimomura A, Awataguchi T, Murakami K, Kobayashi T: A case of angiofibroma originating from the inferior nasal turbinate. Auris Nasus Larynx; 2006 Jun;33(2):191-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of angiofibroma originating from the inferior nasal turbinate.
  • Angiofibromas are nasopharyngeal tumors mostly seen in adolescent males.
  • Extranasopharyngeal angiofibromas, although rare, have been reported.
  • We report a case of extranasopharyngeal angiofibroma arising from the inferior turbinate of a 62-year-old male.
  • Previous extranasopharyngeal angiofibromas research was reviewed.
  • [MeSH-major] Angiofibroma / pathology. Nasopharyngeal Neoplasms / pathology. Turbinates / pathology

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  • (PMID = 16310998.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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40. Douglas R, Wormald PJ: Endoscopic surgery for juvenile nasopharyngeal angiofibroma: where are the limits? Curr Opin Otolaryngol Head Neck Surg; 2006 Feb;14(1):1-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Endoscopic surgery for juvenile nasopharyngeal angiofibroma: where are the limits?
  • PURPOSE OF REVIEW: This article will examine recent publications on the endoscopic management of juvenile nasopharyngeal angiofibromas.
  • RECENT FINDINGS: The use of an endoscopic approach to resect small juvenile nasopharyngeal angiofibromas is supported by excellent results from a number of operative series published in recent years.
  • Large juvenile nasopharyngeal angiofibromas continue to present a considerable surgical challenge, with most being resected by traditional open approaches.
  • However, the results achieved after the endoscopic resection of large tumours have been reported for a small number of cases.
  • This review focuses on the outcome of these cases, which would seem to compare favourably to open series, and the advances in instrumentation and techniques, that facilitate the endoscopic removal of large juvenile nasopharyngeal angiofibromas.
  • SUMMARY: Improvements in preoperative assessment and preparation, operative technique, and instrumentation potentially enable the endoscopic removal of most juvenile nasopharyngeal angiofibromas.
  • [MeSH-major] Angiofibroma / surgery. Endoscopy. Nasopharyngeal Neoplasms / surgery

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  • (PMID = 16467630.001).
  • [ISSN] 1068-9508
  • [Journal-full-title] Current opinion in otolaryngology & head and neck surgery
  • [ISO-abbreviation] Curr Opin Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 30
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41. Starlinger V, Wendler O, Gramann M, Schick B: Laminin expression in juvenile angiofibroma indicates vessel's early developmental stage. Acta Otolaryngol; 2007 Dec;127(12):1310-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Laminin expression in juvenile angiofibroma indicates vessel's early developmental stage.
  • CONCLUSION: This study confirms the wide range of vascular architecture in juvenile angiofibromas.
  • Proof of laminin alpha2 expression in tumour vessels is suggested to indicate presence of vessels of early developmental stage in juvenile angiofibromas, supporting the concept that plexus remnants of the first branchial arch artery contribute to the vascular tumour component.
  • The goal of this study was to analyse the expression of laminins in juvenile angiofibromas.
  • MATERIALS AND METHODS: A detailed analysis of the laminin isoform expression was performed by immunofluorescence staining for laminin chains alpha1, alpha2, alpha3, alpha4, alpha5, beta1, beta2, beta3, gamma1, gamma2, and gamma3 on cryosections of 10 juvenile angiofibromas and inferior nasal turbinate tissue for control.
  • RESULTS: Vascular staining of the different laminin chains revealed areas of differential vessel density in juvenile angiofibromas and irregularities in vessel size, configuration and architecture.
  • Similar to vessels in nasal turbinates, laminins alpha4, alpha5, beta1, beta2 and gamma1 were found to be expressed in juvenile angiofibroma vessels.
  • In contrast to vessels of nasal turbinates, staining for alpha2 and alpha3 chains was only detected in vessels of juvenile angiofibromas.
  • [MeSH-major] Angiofibroma / pathology. Basement Membrane / metabolism. Laminin / metabolism. Nasopharyngeal Neoplasms / pathology

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  • (PMID = 17851944.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Norway
  • [Chemical-registry-number] 0 / Laminin
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42. Thornton M, Mahesh BN, Lang J: Endoscopic resection of a juvenile angiofibroma: the role of the XPS microdebrider. J Laparoendosc Adv Surg Tech A; 2005 Apr;15(2):194-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Endoscopic resection of a juvenile angiofibroma: the role of the XPS microdebrider.
  • Juvenile angiofibromas are vascular tumors found almost exclusively in the adolescent male.
  • Although benign, their clinical course can be aggressive and can result in major morbidity and mortality.
  • Endoscopic transnasal resection of juvenile angiofibromas, confined to the nose, paranasal sinuses, pterygopalatine fossa, and medial infratemporal fossa, has been a significant advance in their management, eliminating or reducing the need for extensive soft tissue and bony dissection of traditional surgical approaches.
  • We discuss a case of a juvenile angiofibroma resected transnasally using the XPS microdebrider (Medtonic Xomed, Jacksonville, Florida) and outline the role of this instrument in this surgery.
  • [MeSH-major] Angiofibroma / surgery. Debridement / instrumentation. Endoscopy / methods. Head and Neck Neoplasms / surgery

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  • (PMID = 15898917.001).
  • [ISSN] 1092-6429
  • [Journal-full-title] Journal of laparoendoscopic & advanced surgical techniques. Part A
  • [ISO-abbreviation] J Laparoendosc Adv Surg Tech A
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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43. Schick B, Wemmert S, Jung V, Steudel WI, Montenarh M, Urbschat S: Genetic heterogeneity of the MYC oncogene in advanced juvenile angiofibromas. Cancer Genet Cytogenet; 2006 Jan 1;164(1):25-31

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Genetic heterogeneity of the MYC oncogene in advanced juvenile angiofibromas.
  • Despite their benign histological appearance, juvenile angiofibromas sometimes exhibit an aggressive growth behavior.
  • Because intensive cross-talk among beta-catenin, androgen receptor, and C-MYC has been detected recently, we analyzed expression of the C-MYC protooncogene (MYC) on the genetic, transcriptional and translational level in seven sporadic juvenile angiofibromas.
  • Two-color in situ hybridization analyses for chromosome 8 and MYC found in all seven juvenile angiofibromas significant MYC losses.
  • In the three advanced juvenile angiofibromas of this series (Fisch stages III and IV) additional significant MYC gains were observed demonstrating a genetic heterogeneity for the MYC protooncogene.
  • Semiquantitative RT-PCR analyses from laser microdissected endothelial cells and fibroblasts found no differences of C-MYC mRNA levels, leaving open the question of the neoplastic cell in juvenile angiofibromas.
  • The finding of genetic MYC heterogeneity associated with C-MYC overexpression on the mRNA and protein level in advanced juvenile angiofibromas indicates involvement of the MYC oncogene in aggressive growth behavior.
  • [MeSH-major] Angiofibroma / genetics. Genes, myc. Genetic Heterogeneity

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  • (PMID = 16364759.001).
  • [ISSN] 0165-4608
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Proto-Oncogene Proteins c-myc; 0 / RNA, Messenger; 0 / Receptors, Androgen; 0 / Transforming Growth Factor beta; 0 / beta Catenin
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44. Porras Alonso EC, Benito Navarro JR, Fernandez Roche JA, Rodriguez Fernández-Freire A: [Child nasopharyngeal angiofibroma]. An Otorrinolaringol Ibero Am; 2005;32(5):483-90

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Child nasopharyngeal angiofibroma].
  • [Transliterated title] Angiofibroma nasofaringeo infantil.
  • Angiofibromas are benign tumors, highly vascularized, that affect male adolescents and young men.
  • We present a clinical case of an 11-year-old patient with an angiofibroma of the nasopharynx, reviewing the etiopathogenic theories and current surgical approaches.
  • [MeSH-major] Angiofibroma / pathology. Angiofibroma / radiography. Nasopharyngeal Neoplasms / pathology. Nasopharyngeal Neoplasms / radiography

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  • (PMID = 16318092.001).
  • [ISSN] 0303-8874
  • [Journal-full-title] Anales otorrinolaringológicos ibero-americanos
  • [ISO-abbreviation] An Otorrinolaringol Ibero Am
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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45. Mentzel T, Kutzner H, Requena L, Hartmann A: [Skin tumors as marker lesions for tumor syndromes]. Pathologe; 2010 Oct;31(6):489-96
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • These syndromes include Muir-Torre syndrome, associated with cystic sebaceomas, Cowden syndrome, associated with multiple tricholemmomas, Carney complex associated with multiple superficial angiomyxomas, Birt-Hogg-Dubé syndrome associated with multiple fibrofolliculomas, tuberous sclerosis associated with multiple facial angiofibromas and so-called Koenen tumors, patients with renal cell cancer associated with pilar leiomyomatosis and uterine leiomyomas, Gardner syndrome associated with Gardner fibromas and nevoid basal cell carcinoma associated with multiple basal cell carcinomas in young patients.
  • [MeSH-minor] Angiofibroma / pathology. Basal Cell Nevus Syndrome / pathology. Birt-Hogg-Dube Syndrome / pathology. Carcinoma, Basal Cell / pathology. Epidermis / pathology. Hamartoma Syndrome, Multiple / pathology. Humans. Kidney Neoplasms / pathology. Leiomyoma / pathology. Male. Muir-Torre Syndrome / pathology. Myxoma / pathology. Syndrome

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  • (PMID = 20960199.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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46. Prabhu S, Mahesh KP: Tuberous sclerosis with oral angiofibroma: case report. Br J Oral Maxillofac Surg; 2010 Apr;48(3):205-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tuberous sclerosis with oral angiofibroma: case report.
  • Tuberous sclerosis is a multisystem disorder characterised by the formation of hamartomas in various parts of the body.
  • We present a patient who presented with facial angiofibromas (adenoma sebaceum), shagreen patches, and epileptic seizures.
  • Oral papules showed histological features of angiofibroma, which was peculiar to this case.
  • [MeSH-major] Angiofibroma / pathology. Facial Neoplasms / pathology. Mouth Neoplasms / pathology. Tuberous Sclerosis / pathology

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  • [Copyright] 2009 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 19640621.001).
  • [ISSN] 1532-1940
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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47. Perić A, Baletić N, Cerović S, Vukomanović-Durdević B: Middle turbinate angiofibroma in an elderly woman. Vojnosanit Pregl; 2009 Jul;66(7):583-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Middle turbinate angiofibroma in an elderly woman.
  • BACKGROUND: Angiofibromas are histologically benign vascular tumors, originating from the nasopharynx, near by the area of sphenopalatine foramen.
  • Reports of primary extranasopharyngeal angiofibromas have appeared sporadically in the literature in English.
  • We present the first case of an elderly woman with tumor arising from the middle turbinate, diagnosed as angiofibroma.
  • After the endoscopic excision of the mass, postoperative pathohistological and immunohistochemical analysis confirmed the diagnosis of an angiofibroma.
  • CONCLUSION: Extranasopharyngeal angiofibromas arising from the nasal cavity are extremely rare tumors.
  • [MeSH-major] Angiofibroma / diagnosis. Nose Neoplasms / diagnosis. Turbinates

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  • (PMID = 19678585.001).
  • [ISSN] 0042-8450
  • [Journal-full-title] Vojnosanitetski pregled
  • [ISO-abbreviation] Vojnosanit Pregl
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Serbia
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48. Micozkadioglu H, Koc Z, Ozelsancak R, Yildiz I: Rapamycin therapy for renal, brain, and skin lesions in a tuberous sclerosis patient. Ren Fail; 2010;32(10):1233-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Tuberous sclerosis complex (TSC) is an inherited multisystem disorder; it may involve kidney, brain, skin, lungs, and liver.
  • We report a 37-year-old female TSC patient presenting with skin lesions (angiofibromas, molluscum pendulum).
  • The number and volume of angiofibromas and molluscum pendulum reduced progressively in 6 months.
  • Oral rapamycin therapy can improve renal, brain, and skin lesions in TSC disease.
  • [MeSH-minor] Adult. Angiofibroma / drug therapy. Angiofibroma / etiology. Facial Neoplasms / drug therapy. Female. Humans. Magnetic Resonance Imaging


49. Uyar M, Turanli M, Pak I, Bakir S, Osma U: Extranasopharyngeal angiofibroma originating from the nasal septum: a case report. Kulak Burun Bogaz Ihtis Derg; 2009 Jan-Feb;19(1):41-4
MedlinePlus Health Information. consumer health - Nasal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extranasopharyngeal angiofibroma originating from the nasal septum: a case report.
  • Angiofibromas (AFs) originate predominantly in the nasopharynx and posterior nasal cavity.
  • Only four cases of extranasopharyngeal angiofibromas arising in the nasal septum have been reported so far.
  • We report here a case of a vascular mass arising from the nasal septum in a 19-year-old boy which was extirpated by submucousal resection endonasally.
  • Histopathology confirmed it to be a case of angiofibroma.
  • [MeSH-major] Angiofibroma / diagnosis. Angiofibroma / surgery. Nasal Septum. Nose Neoplasms / diagnosis. Nose Neoplasms / surgery

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  • (PMID = 19793047.001).
  • [ISSN] 1300-7475
  • [Journal-full-title] Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
  • [ISO-abbreviation] Kulak Burun Bogaz Ihtis Derg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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50. Duerr S, Wendler O, Aigner T, Karosi S, Schick B: Metalloproteinases in juvenile angiofibroma--a collagen rich tumor. Hum Pathol; 2008 Feb;39(2):259-68
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metalloproteinases in juvenile angiofibroma--a collagen rich tumor.
  • MMPs with gelatinase/collagenase activity have not yet been studied in juvenile angiofibroma, a unique fibrovascular tumor with prominent collagen expression.
  • Quantitative real-time polymerase chain reaction studies, Western blot analysis, immunofluorescence studies, gel zymography, and in situ zymography were used to analyze MMP-1, MMP-2, MMP-9, MMP-13, MMP-14, TIMP-1, and TIMP-2 in 9 juvenile angiofibromas and 2 inferior nasal turbinate specimens.
  • Western blot analysis detected more prominent MMP-1, MMP-2, and MMP-9 protein levels in juvenile angiofibromas compared with inferior nasal turbinates, but not MMP-13, MMP-14, TIMP-1, and TIMP-2.
  • Gel zymography indicated increased MMP-2 and MMP-9 gelatinase activity in juvenile angiofibromas compared with inferior nasal turbinates.
  • This study indicates significant expression of MMPs with gelatinase/collagenase activity in juvenile angiofibromas with evidence of a disturbed balance of MMPs to TIMPs toward enhanced MMP activity.
  • [MeSH-major] Angiofibroma / enzymology. Biomarkers, Tumor / metabolism. Collagen / metabolism. Metalloproteases / metabolism. Nose Neoplasms / enzymology

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  • (PMID = 17950779.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 0 / Tissue Inhibitor of Metalloproteinase-1; 127497-59-0 / Tissue Inhibitor of Metalloproteinase-2; 9007-34-5 / Collagen; EC 3.4.- / Metalloproteases
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51. Lee CH, Hong CH, Yu HS, Chen GS, Yang KC: Transforming growth factor-β enhances matrix metalloproteinase-2 expression and activity through AKT in fibroblasts derived from angiofibromas in patients with tuberous sclerosis complex. Br J Dermatol; 2010 Dec;163(6):1238-44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Transforming growth factor-β enhances matrix metalloproteinase-2 expression and activity through AKT in fibroblasts derived from angiofibromas in patients with tuberous sclerosis complex.
  • BACKGROUND: Patients with tuberous sclerosis complex (TSC) develop fibrous tumours in the brain, skin, kidney, heart and lungs due to TSC1/2 mutations.
  • In the skin, patients develop angiofibromas that have vascular and fibrotic components in which transforming growth factor (TGF)-β and matrix metalloproteinase (MMP)-2 are important.
  • OBJECTIVES: To investigate if the TGF-β axis and MMP-2 play an important role in the pathogenesis of TSC angiofibromas.
  • METHODS: Samples from TSC angiofibromas and normal skin were measured for expression of TGF-β and MMP-2 by immunohistochemistry and real-time polymerase chain reaction.
  • Fibroblasts grown from TSC angiofibromas (TSC fibroblasts) were incubated with TGF-β.
  • [MeSH-major] Angiofibroma / enzymology. Fibroblasts / enzymology. Matrix Metalloproteinase 2 / metabolism. Transforming Growth Factor beta / pharmacology. Tuberous Sclerosis / enzymology

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  • [Copyright] © 2010 The Authors. BJD © 2010 British Association of Dermatologists.
  • (PMID = 20698845.001).
  • [ISSN] 1365-2133
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Transforming Growth Factor beta; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases; EC 3.4.24.24 / Matrix Metalloproteinase 2
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52. Szymańska A, Korobowicz E, Gołabek W: A rare case of nasopharyngeal angiofibroma in an elderly female. Eur Arch Otorhinolaryngol; 2006 Jul;263(7):657-60

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A rare case of nasopharyngeal angiofibroma in an elderly female.
  • Nasopharyngeal angiofibromas occur predominantly in males in their puberty and adolescence; the incidence in other age groups and in women is exceptional.
  • This report describes a case of a 57-year-old woman with nasopharyngeal angiofibroma presenting typical radiological findings in computed tomography, MR imaging and angiography.
  • [MeSH-major] Angiofibroma / diagnosis. Angiofibroma / surgery. Nasopharyngeal Neoplasms / diagnosis. Nasopharyngeal Neoplasms / surgery
  • [MeSH-minor] Disease-Free Survival. Female. Follow-Up Studies. Humans. Magnetic Resonance Angiography. Middle Aged. Otorhinolaryngologic Surgical Procedures. Tomography, X-Ray Computed

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  • (PMID = 16625398.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
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53. Martelli H, Lima LS, Bonan PR, Coletta RD: Oral manifestations leading to the diagnosis of familial tuberous sclerosis. Indian J Dent Res; 2010 Jan-Mar;21(1):138-40
MedlinePlus Health Information. consumer health - Tuberous Sclerosis.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We reported herein a nine-year-old boy with dental enamel pits and gingival nodular lesions, histologically diagnosed as angiofibromas that leaded to the diagnosis of a family with TS.
  • [MeSH-major] Angiofibroma / etiology. Dental Enamel Hypoplasia / etiology. Facial Neoplasms / etiology. Gingival Neoplasms / etiology. Tuberous Sclerosis / diagnosis

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  • (PMID = 20427926.001).
  • [ISSN] 1998-3603
  • [Journal-full-title] Indian journal of dental research : official publication of Indian Society for Dental Research
  • [ISO-abbreviation] Indian J Dent Res
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] India
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54. Misago N, Narisawa Y: Fibrofolliculoma in a patient with tuberous sclerosis complex. Clin Exp Dermatol; 2009 Dec;34(8):892-4
MedlinePlus Health Information. consumer health - Tuberous Sclerosis.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The occurrence of multiple fibrofolliculomas or trichodiscomas on the face and neck is clinically characteristic of Birt-Hogg-Dubé (BHD) syndrome, whereas the development of multiple fibrous papules or angiofibromas on the face is an important clinical sign of tuberous sclerosis complex (TSC).
  • It has been suggested that a relationship exists between BHD syndrome and TSC and there was a case of BHD syndrome reported recently, in which multiple fibrous papules or angiofibroma lesions were observed.
  • [MeSH-major] Fibroma / pathology. Hair Follicle / pathology. Skin Neoplasms / pathology. Tuberous Sclerosis / pathology

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  • (PMID = 19196303.001).
  • [ISSN] 1365-2230
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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55. Eversole LR: Cellular angiofibroma of oral mucosa: report of two cases. Head Neck Pathol; 2009 Jun;3(2):136-9
MedlinePlus Health Information. consumer health - Oral Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cellular angiofibroma of oral mucosa: report of two cases.
  • Cellular angiofibroma is a benign vascular neoplasm that typically arises in the vulva, perineal, and paratesticular region.
  • Recent evidence indicates that cellular angiofibromas may be cytogenetically related to spindle cell lipoma.
  • This represents the first reported instances of cellular angiofibroma in the oral cavity.
  • [MeSH-major] Angiofibroma / pathology. Mouth Mucosa / pathology. Mouth Neoplasms / pathology

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  • (PMID = 19644547.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; Angiofibroma / Hemangioma / Mesenchymal tumor / Oral cavity / Vascular tumor
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56. Batra PS, Citardi MJ: Endoscopic management of sinonasal malignancy. Otolaryngol Clin North Am; 2006 Jun;39(3):619-37, x-xi

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The advent of rigid telescopes has revolutionized the management of rhinologic disease.
  • These instruments have been used as a diagnostic and therapeutic tool for paranasal sinus inflammatory diseases since the 1970s.
  • Recently, endoscopic techniques have also been used successfully to manage selected tumors, including inverted papilloma, angiofibromas, and hypophyseal tumors.

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  • (PMID = 16757235.001).
  • [ISSN] 0030-6665
  • [Journal-full-title] Otolaryngologic clinics of North America
  • [ISO-abbreviation] Otolaryngol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 31
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57. Jeyanthi K, Karthikeyan R, Sherlin HJ, Anuja N, Ramani P, Priya P, Chandrasekar T, Khan N, Narayanan V: Pleomorphic adenoma in the infra-temporal space: the first case report. Head Neck Pathol; 2007 Dec;1(2):173-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Tumors that are reported commonly in the infratemporal region are nasopharyngeal carcinomas, juvenile angiofibromas and adenoid cystic carcinomas.
  • To the best of our knowledge, this is the first report in the English language literature of a pleomorphic adenoma presenting in the infratemporal space and probably arising from an ectopic minor salivary gland, along with a brief description of the surgical technique.

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  • (PMID = 20614271.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2807513
  • [Keywords] NOTNLM ; Infratemporal fossa / Pleomorphic adenoma
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58. Noone P, Majid M, Vasu S: Autopsy findings in a case of tuberous sclerosis. J Forensic Leg Med; 2009 Aug;16(6):357-61
MedlinePlus Health Information. consumer health - Tuberous Sclerosis.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Tuberous sclerosis is a neurocutaneous disorder with autosomal dominant inheritance.
  • It is characterized by the triad of seizures, mental retardation, angiofibromas of the face though the triad is not always complete.
  • He also had cortical thickening of bones, cortical tubers of brain, polycystic kidney disease.
  • [MeSH-minor] Adult. Angiofibroma / pathology. Asphyxia / pathology. Facial Neoplasms / pathology. Forensic Pathology. Humans. Lipomatosis / pathology. Male. Neck Injuries / pathology. Polycystic Kidney Diseases / pathology. Suicide

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  • (PMID = 19573851.001).
  • [ISSN] 1878-7487
  • [Journal-full-title] Journal of forensic and legal medicine
  • [ISO-abbreviation] J Forensic Leg Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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59. Celenk P, Alkan A, Canger EM, Günhan O: Fibrolipomatous hamartoma in a patient with tuberous sclerosis: report of a case. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2005 Feb;99(2):202-6
MedlinePlus Health Information. consumer health - Tuberous Sclerosis.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fibrolipomatous hamartoma in a patient with tuberous sclerosis: report of a case.
  • Tuberous sclerosis is a rare congenital disorder with an incidence of 1 in 6000 births.
  • The classic triad is seizure, mental deficiency, and angiofibromas.
  • Orofacial manifestations include fibrous hyperplasia, hemangioma, bifid uvula, cleft lip and palate, macroglossia, high arched palate, and enamel defects.
  • Benign tumors of the jaws including desmoplastic fibroma, calcifying odontogenic tumor, and odontogenic myxoma have been recently reported in tuberous sclerosis.
  • [MeSH-major] Hamartoma / complications. Mandibular Diseases / complications. Tuberous Sclerosis / complications

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  • (PMID = 15660093.001).
  • [ISSN] 1079-2104
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 9007-34-5 / Collagen
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60. Glad H, Vainer B, Buchwald C, Petersen BL, Theilgaard SA, Bonvin P, Lajer C, Jakobsen J: Juvenile nasopharyngeal angiofibromas in Denmark 1981-2003: diagnosis, incidence, and treatment. Acta Otolaryngol; 2007 Mar;127(3):292-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Juvenile nasopharyngeal angiofibromas in Denmark 1981-2003: diagnosis, incidence, and treatment.
  • CONCLUSIONS: Juvenile nasopharyngeal angiofibroma (JNA) is a rare tumor in young males, with a non-negligible potential for recurrence.
  • [MeSH-major] Angiofibroma / diagnosis. Nasopharyngeal Neoplasms / diagnosis

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  • (PMID = 17364367.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Norway
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61. Tasca I, Compadretti GC: Extranasopharyngeal angiofibroma of nasal septum. A controversial entity. Acta Otorhinolaryngol Ital; 2008 Dec;28(6):312-4
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  • [Title] Extranasopharyngeal angiofibroma of nasal septum. A controversial entity.
  • The term extranasopharyngeal angiofibroma has been applied to vascular, fibrous nodules occurring outside the nasopharynx.
  • Typically, clinical characteristics of extranasopharyngeal angiofibromas do not conform with that of nasopharyngeal angiofibromas and, for this reason, these tumours must be regarded as a separate entity.
  • Due to these different features, extranasopharyngeal angiofibromas can present a diagnostic challenge and a meticulous evaluation with a high index of suspicion is essential in establishing the correct diagnosis and treatment.
  • We report the case of a 57-year-old female with a 1-year history of a slowly progressing right nasal obstruction due to the presence of a whitish mass adhering to the posterior nasal septum.
  • Histopathological findings were compatible with a diagnosis of angiofibroma.
  • Extranasopharyngeal angiofibroma must be taken into consideration in the differential diagnosis of nasal vascular tumours and nasal septum should be regarded as a potential, though exceptional, localization of these neoplasms.
  • [MeSH-major] Angiofibroma. Nasal Septum. Nose Neoplasms

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  • [Cites] Int J Pediatr Otorhinolaryngol. 2000 Nov 30;56(1):59-64 [11074117.001]
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  • (PMID = 19205598.001).
  • [ISSN] 0392-100X
  • [Journal-full-title] Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale
  • [ISO-abbreviation] Acta Otorhinolaryngol Ital
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2689538
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62. Timotin L, Sarrot-Reynauld F, Lantuejoul S, Pasquier B, Massot C, Ashraf A, Borgel F: [Tuberous sclerosis without mental impairment, diagnosed in adulthood]. Rev Med Interne; 2005 Jun;26(6):511-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Sclérose tubéreuse de Bourneville sans altération intellectuelle, diagnostiquée à l'âge adulte.
  • EXEGESIS: We report a case of TSC diagnosed in a 33-year-old man, without any known family history of phakomatosis, presenting with facial angiofibromas, hypomelanotic macules, a giant-cell astrocytoma and retinal phakomas without any mental impairment or epilepsy.
  • CONCLUSION: TSC may occur in patients who do not have any family history of phakomatosis because de novo mutations are frequent.
  • Facial angiofibromas are highly suggestive of tuberous sclerosis complex.

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  • (PMID = 15936480.001).
  • [ISSN] 0248-8663
  • [Journal-full-title] La Revue de medecine interne
  • [ISO-abbreviation] Rev Med Interne
  • [Language] FRE
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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63. Gallia GL, Ramanathan M Jr, Blitz AM, Reh DD: Expanded endonasal endoscopic approach for resection of a juvenile nasopharyngeal angiofibroma with skull base involvement. J Clin Neurosci; 2010 Nov;17(11):1423-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expanded endonasal endoscopic approach for resection of a juvenile nasopharyngeal angiofibroma with skull base involvement.
  • Juvenile nasopharyngeal angiofibromas (JNAs) are rare vascular tumors which arise in the nasopharynx of adolescent males.
  • In this report, we describe a patient with a JNA with skull base involvement who underwent an expanded endonasal endoscopic approach for a complete resection.
  • [MeSH-major] Angiofibroma / surgery. Endoscopy / methods. Nasal Cavity / surgery. Nasopharyngeal Neoplasms / surgery. Nasopharynx / surgery. Skull Base Neoplasms / surgery

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  • [Copyright] Copyright © 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20708935.001).
  • [ISSN] 1532-2653
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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64. Grieb S, Kruse R, Bruch-Gerharz D, Reifenberger J: [Tuberous sclerosis: diagnostic criteria and new treatment approaches]. Hautarzt; 2008 Oct;59(10):774-6
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  • Treatment for many years consisted solely in using nonspecific symptomatic approaches; dermatological therapy comprised mainly laser or electroacoustic ablation of facial angiofibromas.
  • [MeSH-major] Dermatologic Agents / therapeutic use. Interferon-gamma / therapeutic use. Skin Diseases / diagnosis. Skin Diseases / drug therapy. Tuberous Sclerosis / diagnosis. Tuberous Sclerosis / drug therapy

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  • [Cites] Am J Hum Genet. 1999 May;64(5):1305-15 [10205261.001]
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  • (PMID = 18806968.001).
  • [ISSN] 1432-1173
  • [Journal-full-title] Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
  • [ISO-abbreviation] Hautarzt
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Dermatologic Agents; 0 / Recombinant Proteins; 82115-62-6 / Interferon-gamma
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65. Snyderman CH, Pant H, Carrau RL, Gardner P: A new endoscopic staging system for angiofibromas. Arch Otolaryngol Head Neck Surg; 2010 Jun;136(6):588-94
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A new endoscopic staging system for angiofibromas.
  • OBJECTIVE: To develop a new staging system for juvenile nasopharyngeal angiofibroma that reflects changes in surgical approaches (endonasal), route of intracranial extension, and the extent of vascular supply from the internal carotid artery.
  • PATIENTS: Patients undergoing endoscopic endonasal surgery for juvenile nasopharyngeal angiofibroma at the University of Pittsburgh Medical Center (UPMC), Pittsburgh, Pennsylvania, from 1998 through 2008.
  • CONCLUSIONS: Tumor size and extent of sinus disease are less important in predicting complete tumor removal with endonasal surgical techniques.
  • The UPMC staging system for juvenile nasopharyngeal angiofibroma accounts for 2 important prognostic factors, route of cranial base extension, and vascularity and is applicable to endoscopic or open approaches.
  • [MeSH-major] Angiofibroma / pathology. Endoscopy. Nasopharyngeal Neoplasms / pathology. Neoplasm Staging / standards

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  • (PMID = 20566910.001).
  • [ISSN] 1538-361X
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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66. Gemmete JJ, Ansari SA, McHugh J, Gandhi D: Embolization of vascular tumors of the head and neck. Neuroimaging Clin N Am; 2009 May;19(2):181-98, Table of Contents
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  • Juvenile nasopharyngeal angiofibromas and paragangliomas are the most common hypervascular tumors of the head and neck that require embolization as an adjunct to surgery.

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  • (PMID = 19442905.001).
  • [ISSN] 1557-9867
  • [Journal-full-title] Neuroimaging clinics of North America
  • [ISO-abbreviation] Neuroimaging Clin. N. Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 80
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67. Datta AK, Mandal S, Bhattacharya S: Autism and mental retardation with convulsion in tuberous sclerosis: a case report. Cases J; 2009;2:7061

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  • A 6-year-old male child born of a non-consanguineous marriage admitted in the pediatrics emergency ward with the history of recurrent attacks of convulsion since 4 month of age.
  • Examination revealed that the child had characteristics features of angiofibromas on the face with butterfly distribution, hyperpigmented patches on forehead, hypopigmented macules on trunk, prominent subependymal and cortical tubers.

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  • (PMID = 19829902.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2740157
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68. Klockars T, Renkonen S, Leivo I, Hagström J, Mäkitie AA: Juvenile nasopharyngeal angiofibroma: no evidence for inheritance or association with familial adenomatous polyposis. Fam Cancer; 2010 Sep;9(3):401-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Juvenile nasopharyngeal angiofibroma: no evidence for inheritance or association with familial adenomatous polyposis.
  • Juvenile nasopharyngeal angiofibromas (JNAs) are rare tumors with prominent vascularity and locally destructive growth.
  • Twenty-one patients diagnosed with juvenile angiofibroma filled out a detailed patient questionnaire.
  • No patients reported any relatives with nasopharyngeal angiofibroma or familial adenomatous polyposis.
  • [MeSH-major] Adenomatous Polyposis Coli / genetics. Angiofibroma / genetics. Genetic Predisposition to Disease. Nasopharyngeal Neoplasms / genetics

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  • (PMID = 20229070.001).
  • [ISSN] 1573-7292
  • [Journal-full-title] Familial cancer
  • [ISO-abbreviation] Fam. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
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69. Krueger DA, Franz DN: Current management of tuberous sclerosis complex. Paediatr Drugs; 2008;10(5):299-313
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  • Tuberous sclerosis complex (TSC) is an important cause of epilepsy, autism, and renal and pulmonary disease in children and adults.
  • The clinical course of TSC and the prognosis and appropriate therapy for TSC patients are often different than that for individuals with epilepsy, renal tumors, or interstitial lung disease from other causes.
  • In addition, recent clinical trials using inhibitors of the mammalian target of rapamycin (mTOR) have demonstrated regression of astrocytomas, angiofibromas, and angiomyoliomas, as well as improved pulmonary function in persons with TSC.
  • [MeSH-minor] Antibiotics, Antineoplastic / therapeutic use. Child. Humans. Kidney Diseases / drug therapy. Kidney Diseases / etiology. Lung Diseases / drug therapy. Lung Diseases / etiology. Nervous System Diseases / drug therapy. Nervous System Diseases / etiology. Sirolimus / therapeutic use

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  • (PMID = 18754697.001).
  • [ISSN] 1174-5878
  • [Journal-full-title] Paediatric drugs
  • [ISO-abbreviation] Paediatr Drugs
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] New Zealand
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; W36ZG6FT64 / Sirolimus
  • [Number-of-references] 123
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70. Vidal A, Iglesias MJ, Fernández B, Fonseca E, Cordido F: Cutaneous lesions associated to multiple endocrine neoplasia syndrome type 1. J Eur Acad Dermatol Venereol; 2008 Jul;22(7):835-8
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  • BACKGROUND: Multiple endocrine neoplasia type 1 (MEN1) is a genetic disease that predisposes to endocrine tumour development.
  • Some cutaneous lesions (angiofibromas, collagenomas, melanosis guttaca, lipomas, melanomas, 'cafe au lait macules') have been associated to this syndrome.
  • The frequency of angiofibromas was lower (22.2%) than the reported in other studies (43-88%), and we did not find any collagenoma.
  • [MeSH-major] Angiofibroma / epidemiology. Lipoma / epidemiology. Multiple Endocrine Neoplasia Type 1 / epidemiology. Proto-Oncogene Proteins / genetics. Skin Neoplasms / epidemiology
  • [MeSH-minor] Adenoma / epidemiology. Adenoma / genetics. Adult. Female. Genetic Predisposition to Disease / epidemiology. Genetic Testing. Humans. Hyperparathyroidism / epidemiology. Hyperparathyroidism / genetics. Male. Middle Aged. Pancreatic Neoplasms / epidemiology. Pancreatic Neoplasms / genetics. Pituitary Neoplasms / epidemiology. Pituitary Neoplasms / genetics. Prevalence

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  • (PMID = 18435740.001).
  • [ISSN] 1468-3083
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / MEN1 protein, human; 0 / Proto-Oncogene Proteins
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71. Sinha R, Das S, Ray S, Banerjee P, Sadhu P: Nasopharyngeal angiofibroma: rare presentations. Ear Nose Throat J; 2008 Dec;87(12):E26

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nasopharyngeal angiofibroma: rare presentations.
  • Nasopharyngeal angiofibromas are benign tumors of the nasopharynx that occur in adolescent boys.
  • Two interesting cases of angiofibroma with atypical presentations, showing extensive spread in multiple directions, are reported here.
  • In one case, the angiofibroma exited the right nostril as a large polypoidal mass and also presented as an intraoral tumor in the right upper gingivo-alveolar region.
  • [MeSH-major] Angiofibroma / pathology. Nasopharyngeal Neoplasms / pathology

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  • (PMID = 19105131.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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72. Eze NN, Wyatt ME, Bray D, Bailey CM, Hartley BE: The midfacial degloving approach to sinonasal tumours in children. Rhinology; 2006 Mar;44(1):36-8
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  • The procedure allows access to benign and malignant lesions of the sinonasal region with the avoidance of an external scar.
  • Eight children had benign pathology.
  • There were two juvenile angiofibromas, two nasal gliomas, one ossifying fibroma, one fibroma, one fibrous dysplasia and one benign myofibroblastic proliferation.
  • One child had malignant disease in the form of recurrent embryonal rhabdomyosarcoma.

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  • (PMID = 16550948.001).
  • [ISSN] 0300-0729
  • [Journal-full-title] Rhinology
  • [ISO-abbreviation] Rhinology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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73. Muhammed K, Mathew J: Coexistence of two neurocutaneous syndromes: tuberous sclerosis and hypomelanosis of Ito. Indian J Dermatol Venereol Leprol; 2007 Jan-Feb;73(1):43-5
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  • He also had facial angiofibromas, ash-leaf and confetti macules and shagreen patches.
  • [MeSH-minor] Angiofibroma / complications. Brain / pathology. Child, Preschool. Epilepsy / complications. Facial Neoplasms / complications. Humans. Intellectual Disability / complications. Magnetic Resonance Imaging. Male

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  • (PMID = 17314448.001).
  • [ISSN] 0973-3922
  • [Journal-full-title] Indian journal of dermatology, venereology and leprology
  • [ISO-abbreviation] Indian J Dermatol Venereol Leprol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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74. Xia Y, Darling TN: Rapidly growing collagenomas in multiple endocrine neoplasia type I. J Am Acad Dermatol; 2007 May;56(5):877-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Patients with multiple endocrine neoplasia type I (MEN-I) frequently develop skin lesions including collagenomas, angiofibromas, and lipomas.
  • We report a patient with MEN-I who exhibited rapid growth of multiple collagenomas after pancreatic enucleation of a vasoactive intestinal peptide-secreting tumor (VIPoma) and excision of multiple pancreatic masses.
  • [MeSH-major] Multiple Endocrine Neoplasia Type 1 / complications. Pancreatic Neoplasms / secondary. Skin Diseases / etiology. Vipoma / surgery

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  • (PMID = 17188781.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 9007-34-5 / Collagen
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75. Swaroop Mr, Nischal Kc, Rajesh Gowda Cm, Umashankar Nu, Basavaraj Hb, Sathyanarayana Bd: Radiofrequency ablation of adenoma sebaceum. J Cutan Aesthet Surg; 2008 Jul;1(2):89-91

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Histologically, they are angiofibromas that occur over the central part of the face and hence, cause a major cosmetic disfigurement.

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  • (PMID = 20300351.001).
  • [ISSN] 0974-5157
  • [Journal-full-title] Journal of cutaneous and aesthetic surgery
  • [ISO-abbreviation] J Cutan Aesthet Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2840910
  • [Keywords] NOTNLM ; Adenoma sebaceum / disfigurement / radiofrequency / tuberous sclerosis
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76. Durko M, Murlewska A, Gryczyński M, Ratyńska M, Pietruszewska W: [Angiofibroma of the nasal cavity and anterior ethmoid cells--problems in differential diagnosis]. Otolaryngol Pol; 2007;61(5):736-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Angiofibroma of the nasal cavity and anterior ethmoid cells--problems in differential diagnosis].
  • [Transliterated title] Angiofibroma jamy nosa i komórek sitowych przednich u kobiety--problemy diagnostyki róznicowej.
  • BACKGROUND: Nasal angiofibromas are commonly called juvenile nasal angiofibromas (JNA) because of the almost exclusive occurrence in adolescent males.
  • It is a relatively rare benign fibrovascular tumor originating in the posterior lateral wall of the nasopharynx with only a very few cases diagnosed in females.
  • CASE REPORT: Authors present a case of a 26 y.o. woman with JNA in left nasal cavity with extension to the anterior left ethmoid cells diagnosed and surgically treated at the ENT Department, Medical University of Lodz.
  • CONCLUSION: Although angiofibroma in females is an extremely rare tumor of a sinonasal tract it should be taken into consideration in the differential diagnosis of all nasal cavity tumors (especially solitary fibrous tumor).
  • [MeSH-major] Angiofibroma / pathology. Ethmoid Sinus / pathology. Nose Neoplasms / pathology

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  • (PMID = 18552009.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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77. Cherekaev VA, Gol'bin DA, Kapitanov DN, Belov AI, Arustamian SR, Gromova VV, Imaev AA: [Surgical treatment of extensive craniofacial juvenile angiofibromas]. Zh Vopr Neirokhir Im N N Burdenko; 2009 Apr-Jun;(2):9-14; discussion 14-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Surgical treatment of extensive craniofacial juvenile angiofibromas].
  • Juvenile nasopharyngeal angiofibroma (JNA) is a rare benign tumor occurring almost exclusively in adolescent and young adult males.
  • [MeSH-major] Angiofibroma / surgery. Nasopharyngeal Neoplasms / surgery. Otorhinolaryngologic Surgical Procedures / methods

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  • (PMID = 19569543.001).
  • [ISSN] 0042-8817
  • [Journal-full-title] Zhurnal voprosy neĭrokhirurgii imeni N. N. Burdenko
  • [ISO-abbreviation] Zh Vopr Neirokhir Im N N Burdenko
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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78. Lopez JP, Ossandón D, Miller P, Sánchez L, Winter A: Unilateral eyelid angiofibroma with complete blepharoptosis as the presenting sign of tuberous sclerosis. J AAPOS; 2009 Aug;13(4):413-4
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  • [Title] Unilateral eyelid angiofibroma with complete blepharoptosis as the presenting sign of tuberous sclerosis.
  • Tuberous sclerosis is a multisystem autosomal-dominant disease characterized by hamartomatous growths in the brain, skin, kidneys, eyes, and heart, but it may affect almost any organ.
  • Nonretinal findings include angiofibromas of the eyelid, strabismus, and pseudo-colobomas of the lens and iris.
  • We report a case of a newborn with congenital eyelid angiofibroma mimicking complete congenital blepharoptosis that was revealed by central nervous system imaging to be part of the tuberous sclerosis complex.

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  • (PMID = 19683195.001).
  • [ISSN] 1528-3933
  • [Journal-full-title] Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus
  • [ISO-abbreviation] J AAPOS
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / GABA Agents; 614OI1Z5WI / Valproic Acid; GR120KRT6K / Vigabatrin
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79. Cansiz H, Güvenç MG, Sekercioğlu N: Surgical approaches to juvenile nasopharyngeal angiofibroma. J Craniomaxillofac Surg; 2006 Jan;34(1):3-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical approaches to juvenile nasopharyngeal angiofibroma.
  • INTRODUCTION: Juvenile nasopharyngeal angiofibromas are highly vascular, non-encapsulated tumours affecting predominantly young males.
  • These lesions are benign histologically but they may become life-threatening with excessive bleeding or intracranial extension.
  • MATERIAL AND METHODS: The surgical approaches to 22 male patients with nasopharyngeal angiofibromas are reviewed.
  • CONCLUSION: The suggested treatment of juvenile nasopharyngeal angiofibroma consists of an endoscopic transnasal approach for early stage lesions, and a modified midfacial degloving for almost all of the advanced lesions.
  • [MeSH-major] Angiofibroma / surgery. Nasopharyngeal Neoplasms / surgery. Oral Surgical Procedures / methods
  • [MeSH-minor] Adolescent. Adult. Carotid Artery Injuries / etiology. Carotid Artery, Internal / pathology. Child. Craniotomy / adverse effects. Endoscopy. Facial Paralysis / etiology. Frontal Bone / surgery. Humans. Male. Neoplasm Staging. Nose / surgery. Nose Diseases / etiology. Paresthesia / etiology. Postoperative Complications. Retrospective Studies. Rupture. Temporal Bone / surgery. Treatment Outcome

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  • (PMID = 16343920.001).
  • [ISSN] 1010-5182
  • [Journal-full-title] Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
  • [ISO-abbreviation] J Craniomaxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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80. Ponti G, Losi L, Pellacani G, Rossi GB, Presutti L, Mattioli F, Villari D, Wannesson L, Alicandri Ciufelli M, Izzo P, De Rosa M, Marone P, Seidenari S: Wnt pathway, angiogenetic and hormonal markers in sporadic and familial adenomatous polyposis-associated juvenile nasopharyngeal angiofibromas (JNA). Appl Immunohistochem Mol Morphol; 2008 Mar;16(2):173-8
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  • [Title] Wnt pathway, angiogenetic and hormonal markers in sporadic and familial adenomatous polyposis-associated juvenile nasopharyngeal angiofibromas (JNA).
  • Juvenile nasopharyngeal angiofibroma (JNA) is a rare, invasive, and locally destructive tumor of the nasopharynx.

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  • (PMID = 18227724.001).
  • [ISSN] 1541-2016
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cadherins; 0 / Receptors, Androgen; 0 / Wnt Proteins; 0 / beta Catenin; EC 2.7.10.1 / Receptors, Vascular Endothelial Growth Factor
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81. Riggs S, Orlandi RR: Juvenile nasopharyngeal angiofibroma recurrence associated with exogenous testosterone therapy. Head Neck; 2010 Jun;32(6):812-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Juvenile nasopharyngeal angiofibroma recurrence associated with exogenous testosterone therapy.
  • BACKGROUND: Juvenile nasopharyngeal angiofibromas (JNAs) are rare benign lesions that express hormonal receptors.
  • This report describes a recurrence of a JNA 20 years after excision associated with exogenous testosterone therapy.
  • METHODS: A 36-year-old man developed a sphenoid mass 20 years following resection of a JNA, shortly after initiating exogenous testosterone therapy for symptomatic low endogenous testosterone.
  • [MeSH-major] Angiofibroma / physiopathology. Nasopharyngeal Neoplasms / physiopathology. Neoplasms, Second Primary / physiopathology. Paranasal Sinus Neoplasms / physiopathology. Sphenoid Sinus. Testosterone / physiology

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  • [Copyright] (c) 2009 Wiley Periodicals, Inc. Head Neck, 2010.
  • (PMID = 19626637.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 3XMK78S47O / Testosterone
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82. Feiz-Erfan I, Han PP, Spetzler RF, Porter RW, Klopfenstein JD, Ferreira MA, Beals SP, Joganic EF: Exposure of midline cranial base without a facial incision through a combined craniofacial-transfacial procedure. Neurosurgery; 2005 Jan;56(1 Suppl):28-35; discussion 28-35
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Between 1992 and 1998, eight patients underwent surgery for five different anterior cranial base pathological findings: four angiofibromas, one mesenchymal chondrosarcoma, one esthesioneuroblastoma, one odontogenic myxoma, and one encephalocele.
  • In all cases, the surgical exposure consisted of a bicoronal scalp incision with a bifrontal craniotomy and fronto-orbitonasal osteotomy, and then a sublabial incision for transmaxillary exposure.

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  • (PMID = 15799790.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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83. Lehmann M, Ulrich S, Reineke U, Hamberger U, Dietrich U, Sudhoff H: [Intratumoral Onyx embolisation in the management of juvenile nasopharyngeal angiofibroma]. HNO; 2010 Aug;58(8):853-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Intratumoral Onyx embolisation in the management of juvenile nasopharyngeal angiofibroma].
  • Preoperative embolization for the treatment of juvenile nasopharyngeal angiofibroma was successfully accomplished with Onyx by intratumoral puncture for the first time.
  • Transnasal surgery on the following day achieved complete resection of the angiofibroma without complications.
  • Direct intratumoral embolization of juvenile nasopharyngeal angiofibromas appears to be a safe and effective preoperative method without complications.
  • [MeSH-major] Angiofibroma / blood supply. Angiofibroma / surgery. Dimethyl Sulfoxide. Embolization, Therapeutic / methods. Nasopharyngeal Neoplasms / blood supply. Nasopharyngeal Neoplasms / surgery. Polyvinyls. Preoperative Care

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  • [Cites] Nihon Jibiinkoka Gakkai Kaiho. 2005 May;108(5):513-21 [15952338.001]
  • [Cites] Australas Radiol. 1989 Nov;33(4):348-50 [2561258.001]
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  • [Cites] Ear Nose Throat J. 2008 May;87(5):256 [18572778.001]
  • (PMID = 20596683.001).
  • [ISSN] 1433-0458
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Onyx copolymer; 0 / Polyvinyls; YOW8V9698H / Dimethyl Sulfoxide
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84. de Brito Macedo Ferreira LM, Gomes EF, Azevedo JF, Souza JR, de Paula Araújo R, do Nascimento Rios AS: Endoscopic surgery of nasopharyngeal angiofibroma. Braz J Otorhinolaryngol; 2006 Jul-Aug;72(4):475-80

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Endoscopic surgery of nasopharyngeal angiofibroma.
  • Nasopharyngeal angiofibroma is a vascular benign tumor that affects young men, and surgery is the treatment of choice.
  • Endoscopic surgery has been used to excise tumors in their initial stages, when there is no evidence of residual or recurrent disease.
  • AIM: The aim of this study is to evaluate the endoscopic approach preceded by tumor embolization as treatment option for stages II to III angiofibroma.
  • CONCLUSION: Based on the results, we may conclude that the endoscopic approach, when preceded by embolization, is effective to treat angiofibromas in their initial stages, with reduced postoperative morbidity.
  • [MeSH-major] Angiofibroma / therapy. Nasopharyngeal Neoplasms / therapy

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  • (PMID = 17143426.001).
  • [ISSN] 1808-8694
  • [Journal-full-title] Brazilian journal of otorhinolaryngology
  • [ISO-abbreviation] Braz J Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
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85. Sun XF, Yan CL, Fang L, Shen FM, Liao KH: Cutaneous lesions and visceral involvement of tuberous sclerosis. Chin Med J (Engl); 2005 Feb 5;118(3):215-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Tuberous sclerosis (TS) is an autosomal dominant disorder with a significant range of clinical expressions.
  • They were followed by facial angiofibromas and Shangreen's patch in a decreasing frequency.
  • Forehead plaque, facial angiofibromas and Shagreen's patch appeared in patients at mean age of 2.6, 6.0 and 8.1 years respectively.
  • CONCLUSIONS: Cutaneous features of TS are helpful in the early diagnosis of the disease.

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  • (PMID = 15740650.001).
  • [ISSN] 0366-6999
  • [Journal-full-title] Chinese medical journal
  • [ISO-abbreviation] Chin. Med. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
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86. Sakamoto A, Weinstein LS, Plagge A, Eckhaus M, Kelsey G: GNAS haploinsufficiency leads to subcutaneous tumor formation with collagen and elastin deposition and calcification. Endocr Res; 2009;34(1-2):1-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We now describe the development of fibrous tumors in mice with heterozygous disruption of the Gnas gene, which encodes G(s)alpha and other gene products.
  • METHODS AND RESULTS: Disruption of Gnas exon 2 on either the maternal or paternal allele (Gnas(E2-/+)) results in fibromas or angiofibromas on the ears, paws and tail beginning at 4 months of age.
  • [MeSH-major] Angiofibroma / genetics. Collagen / metabolism. Elastin / metabolism. Fibroma / genetics. GTP-Binding Protein alpha Subunits, Gs / genetics. Skin Neoplasms / genetics

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  • [Cites] J Biol Chem. 2000 Jun 16;275(24):18602-10 [10764764.001]
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  • (PMID = 19557586.001).
  • [ISSN] 1532-4206
  • [Journal-full-title] Endocrine research
  • [ISO-abbreviation] Endocr. Res.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z01 DK043302-14
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] England
  • [Chemical-registry-number] 9007-34-5 / Collagen; 9007-58-3 / Elastin; EC 3.6.1.- / Gnas protein, mouse; EC 3.6.5.1 / GTP-Binding Protein alpha Subunits, Gs
  • [Other-IDs] NLM/ NIHMS79043; NLM/ PMC2702697
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87. McNiff JM, Subtil A, Cowper SE, Lazova R, Glusac EJ: Cellular digital fibromas: distinctive CD34-positive lesions that may mimic dermatofibrosarcoma protuberans. J Cutan Pathol; 2005 Jul;32(6):413-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cellular digital fibromas: distinctive CD34-positive lesions that may mimic dermatofibrosarcoma protuberans.
  • BACKGROUND: Digital fibromas are common benign acral tumors typically reported as angiofibromas (AFs) or acquired digital fibrokeratomas (ADFs).
  • We compared the histologic and immunohistochemical features of these cellular fibromas with five digital AFs, five ADFs, and five digital dermatofibromas.
  • RESULTS: The 14 cellular digital fibromas showed intersecting fascicles of thin delicate bland spindle cells in the superficial reticular dermis with a fibrotic-to-slight myxoid stroma.
  • CONCLUSIONS: These findings suggest that a subset of digital fibromas is characterized by a dense cellular proliferation of CD34-positive spindle cells.
  • Awareness of this variant of digital fibroma and its staining pattern is critical in preventing misdiagnosis as dermatofibrosarcoma protuberans, particularly in superficial biopsies.
  • [MeSH-major] Dermatofibrosarcoma / pathology. Fibroma / pathology. Fingers / pathology. Neoplasms, Connective Tissue / pathology. Skin Neoplasms / pathology

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  • [CommentIn] J Cutan Pathol. 2006 Nov;33(11):762-3; author reply 764 [17083699.001]
  • (PMID = 15953374.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers, Tumor
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88. Gupta M, Motwani G, Gupta P: Extranasopharyngeal angiofibroma arising from the infratemporal region. Indian J Otolaryngol Head Neck Surg; 2006 Jul;58(3):312-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extranasopharyngeal angiofibroma arising from the infratemporal region.
  • Angiofibroma is a histologically benign but locally invasive tumour of the blood vessels characterized by architecturally irregular vessels set in a fibrous stroma.
  • It is rare to find extranasopharyngeal origin of angiofibromas.
  • The infratemporal fossa is a very rare site of extra nasopharyngeal angiofibroma with only 4 cases reported in the literature.
  • We report here a case of a vascular mass arising from the infratemporal fossa of a 13-year-old boy that was confirmed to be a case of angiofibroma histopathologically.
  • A review is also made of the other reported cases of angiofibroma arising from the infratemporal fossa.

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  • [Cites] J Oral Surg Anesth Hosp Dent Serv. 1961 Jul;19:296-301 [13717860.001]
  • [Cites] Ann Otol Rhinol Laryngol. 1961 Mar;70:164-70 [13715796.001]
  • (PMID = 23120330.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3450408
  • [Keywords] NOTNLM ; Extranasopharyngeal angiofibroma
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89. Krstulja M, Car A, Bonifacić D, Braut T, Kujundzić M: Nasopharyngeal angiofibroma with intracellular accumulation of SPARC - a hypothesis (SPARC in nasopharyngeal angiofibroma). Med Hypotheses; 2008;70(3):600-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nasopharyngeal angiofibroma with intracellular accumulation of SPARC - a hypothesis (SPARC in nasopharyngeal angiofibroma).
  • Nasopharyngeal angiofibroma is a histologically benign tumor composed of stroma and vessels.
  • Some nasopharyngeal angiofibromas are resistant to surgical therapy because of extensive growth and occasionally bone destruction.
  • Because the cell of origin of nasopharyngeal angiofibroma is not recognized yet, it would be of interest to discuss molecule(s) relevant to all the cell components of the growth.
  • We propose that in nasopharyngeal angiofibroma the molecule responding to the cues mentioned above is SPARC (secreted protein acidic rich in cystein).
  • We discuss SPARC-enabling formation of molecular complexes important for the angiogenic events and present nasopharyngeal angiofibroma as a hyperplastic angiogenic machinery or a "soil" without "seed".
  • Therapeutic targeting of SPARC in nasopharyngeal angiofibroma would be targeting of a molecule at the roots of cooperation between stromatogenesis and angiogenesis, coexpressed with Ki67 in the vascular compartment.
  • Considering the intracellular accumulation of SPARC, the benefit of (anti) SPARC therapy in nasopharyngeal angiofibroma is yet to be proved.
  • [MeSH-major] Angiofibroma / pathology. Nasopharyngeal Neoplasms / pathology. Osteonectin / metabolism

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  • (PMID = 17681430.001).
  • [ISSN] 0306-9877
  • [Journal-full-title] Medical hypotheses
  • [ISO-abbreviation] Med. Hypotheses
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
  • [Chemical-registry-number] 0 / Osteonectin
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90. Altraide DD, George IO, Otike-Odibe B: Tuberous sclerosis: a rare cause of seizure in Nigeria. Niger J Med; 2010 Jul-Sep;19(3):326-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Tuberous sclerosis is a rare genetic multisystem disorder that is typically apparent shortly after birth.
  • Dermatologic manifestations may be the only clues to the diagnosis of the disorder, which is also marked by childhood seizures and mental retardation.
  • METHODS: A review of the case records of a child with angiofibromas of the face and neck and the relevant literature.
  • Physical examination showed that he had labile mood with presence of hyperpigmented papulonodular (angiofibromas) eruptions on the malar area of the face and neck.
  • He is being managed by a team of a paediatric neurologist, surgeon, speech therapist and a dermatologist.
  • [MeSH-minor] Analgesics, Non-Narcotic / therapeutic use. Carbamazepine / therapeutic use. Child. Humans. Male. Nigeria. Parietal Lobe / radiography. Skin Diseases / etiology. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 20845641.001).
  • [ISSN] 1115-2613
  • [Journal-full-title] Nigerian journal of medicine : journal of the National Association of Resident Doctors of Nigeria
  • [ISO-abbreviation] Niger J Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Nigeria
  • [Chemical-registry-number] 0 / Analgesics, Non-Narcotic; 33CM23913M / Carbamazepine
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91. Gengler C, Guillou L: Solitary fibrous tumour and haemangiopericytoma: evolution of a concept. Histopathology; 2006 Jan;48(1):63-74

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Solitary fibrous tumour and haemangiopericytoma: evolution of a concept.
  • Over the years, it appeared that this growth pattern was a non-specific one, shared by numerous, unrelated benign and malignant lesions, and that HPC was better considered as a diagnosis of exclusion.
  • They generally show a benign clinical course, and include glomangiopericytoma/myopericytoma, infantile myofibromatosis (previously called infantile HPC), and a subset of sinonasal HPCs.
  • The third category is the solitary fibrous tumour (SFT) lesional group, which includes fibrous-to-cellular SFTs, and related lesions such as giant cell angiofibromas and lipomatous HPCs.
  • [MeSH-major] Fibroma / diagnosis. Hemangiopericytoma / diagnosis. Soft Tissue Neoplasms / diagnosis

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  • (PMID = 16359538.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 70
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92. Carrillo JF, Celis MA, Ramirez-Ortega M, Rivas B, Ochoa FJ: Osteoplastic maxillotomy for treatment of neoplasms of the nasopharynx and infratemporal fossa. Ann Otol Rhinol Laryngol; 2005 Jan;114(1 Pt 1):58-64

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Ten patients underwent osteoplastic maxillotomy, 3 of whom had a diagnosis of malignancy, and 7 of whom had nasopharyngeal angiofibromas (NPAs).
  • The patients who had malignancies are alive with no disease, and there was 1 recurrence among the 7 patients with NPAs.
  • [MeSH-minor] Adolescent. Adult. Aged. Angiofibroma / surgery. Carcinoma, Adenoid Cystic / surgery. Carcinoma, Squamous Cell / surgery. Craniotomy. Esthetics. Female. Hemangiopericytoma / surgery. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / surgery. Quality of Life. Treatment Outcome. Zygoma / surgery

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  • (PMID = 15697164.001).
  • [ISSN] 0003-4894
  • [Journal-full-title] The Annals of otology, rhinology, and laryngology
  • [ISO-abbreviation] Ann. Otol. Rhinol. Laryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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93. Haq MZ, Dubey I, Khess CR, Das U, Kumar R: Bipolar disorder and tuberous sclerosis complex: is it a mere coincidence? CNS Spectr; 2009 Nov;14(11):643-7
MedlinePlus Health Information. consumer health - Tuberous Sclerosis.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bipolar disorder and tuberous sclerosis complex: is it a mere coincidence?
  • There are very few reports of bipolar disorder in TSC.
  • The authors present the case of a patient with TSC having bipolar disorder manifesting as manic as well as depressive episodes.
  • The diagnosis of TSC was based on the presence of facial angiofibromas, enamel pits, and shagreen patches on clinical examination, and the presence of cortical tubers and calcified subependymal nodules on neuroimaging.
  • To our knowledge, this is the first report of TSC with bipolar disorder having both manic as well as depressive episodes.
  • The nature of association between TSC and bipolar disorder, and its clinical implications are discussed.
  • [MeSH-major] Bipolar Disorder / etiology. Tuberous Sclerosis / complications


94. Benatiya AI, Bouayed MA, Touiza E, Daoudi K, Mernissi FZ, Tahri H: [Bourneville's tuberous sclerosis. A case report]. J Fr Ophtalmol; 2005 Dec;28(10):e11
MedlinePlus Health Information. consumer health - Tuberous Sclerosis.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] La sclérose tubéreuse de Bourneville. A propos d'un cas.
  • INTRODUCTION: Bourneville's tuberous sclerosis (BTS) is an autosomal dominant phakomatosis characterized by the development of a benign hamartoma-like tumor, which is usually located in the skin, kidney, heart, brain, and eyes.
  • We present here a case of a retinal BTS of late diagnosis.
  • Dermatologic examination also showed facial angiofibromas.
  • The chest X-ray, renal scan, heart scan and a CT scan of the brain failed to show any other localizations of the disease.

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  • (PMID = 16395191.001).
  • [ISSN] 1773-0597
  • [Journal-full-title] Journal français d'ophtalmologie
  • [ISO-abbreviation] J Fr Ophtalmol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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95. Jóźwiak J, Galus R: Molecular implications of skin lesions in tuberous sclerosis. Am J Dermatopathol; 2008 Jun;30(3):256-61
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Tuberous sclerosis (TS), neurocutaneous disorder resulting from the mutation of 1 of 2 genes, TSC1 or TSC2, is often associated with the formation of hamartomatous lesions in various organ systems, including the skin.
  • TS patients may present with hypomelanic macules, confetti-like spots, facial angiofibromas, ungual fibromas, shagreen patches, forehead plaques, and other dermatological signs.
  • Little is known however on molecular links connecting disease pathogenesis and formation of such hamartomas.
  • In the current review, we describe molecular pathways thought to be responsible for the development of the disease and show how their upregulation may affect the skin.
  • [MeSH-major] Proto-Oncogene Proteins c-akt / genetics. Skin Diseases / genetics. Tuberous Sclerosis / genetics


96. Thuesen AD, Jakobsen J, Nepper-Rasmussen J: [Treatment of juvenile angiofibroma with particle embolization and endoscopic surgery]. Ugeskr Laeger; 2005 Aug 22;167(34):3167-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Treatment of juvenile angiofibroma with particle embolization and endoscopic surgery].
  • [Transliterated title] Behandling af juvenile angiofibromer med partikelembolisering og endoskopisk kirurgi.
  • INTRODUCTION: Juvenile angiofibroma is a benign, rich vascular nasal tumor, and the biggest complication in surgery is the great loss of blood.
  • DISCUSSION: Endovascular embolization of juvenile angiofibromas followed by endoscopic surgery is considered to be the preferred treatment method today.
  • [MeSH-major] Angiofibroma / therapy. Embolization, Therapeutic / methods. Nasopharyngeal Neoplasms / therapy

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  • [CommentIn] Ugeskr Laeger. 2005 Nov 21;167(47):4482 [16305784.001]
  • (PMID = 16117915.001).
  • [ISSN] 1603-6824
  • [Journal-full-title] Ugeskrift for laeger
  • [ISO-abbreviation] Ugeskr. Laeg.
  • [Language] dan
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Denmark
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97. Gołabek W, Szymańska A, Siwiec H, Trojanowski P: [Transpalatal approach for juvenile angiofibroma]. Otolaryngol Pol; 2008;62(1):16-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Transpalatal approach for juvenile angiofibroma].
  • INTRODUCTION: Juvenile nasopharyngeal angiofibromas (JNA) are highly vascular, locally invasive tumours which originate in the sphenopalatine foramen.
  • The aim of this study was to evaluate the transpalatal approach for juvenile angiofibroma.
  • [MeSH-major] Angiofibroma / surgery. Nasopharyngeal Neoplasms / surgery. Otorhinolaryngologic Surgical Procedures / methods. Paranasal Sinus Neoplasms / surgery

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  • (PMID = 18637415.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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98. Vasudevan B, Sawhney MP, Radhakrishnan S, Shilpa G: Tuberous sclerosis with portal vein thrombosis, protein C and S deficiency. Indian J Dermatol Venereol Leprol; 2007 Nov-Dec;73(6):412-4
MedlinePlus Health Information. consumer health - Tuberous Sclerosis.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • On examination, angiofibromas on face, shagreen patch and periungual fibromas were observed.
  • [MeSH-minor] Adult. Angiofibroma / complications. Brain Diseases / complications. Dental Fissures / complications. Facial Neoplasms / complications. Female. Fibroma / complications. Hamartoma / complications. Humans. Kidney Diseases / complications. Retinal Diseases / complications


99. Belcadhi M, Mani R, Harzallah M, Bouaouina N, Bouzouita K: [Nasopharyngeal angiofibroma with intracranial extension: situating the chemotherapy-radiotherapy association]. Cancer Radiother; 2008 Sep;12(5):385-8
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  • [Title] [Nasopharyngeal angiofibroma with intracranial extension: situating the chemotherapy-radiotherapy association].
  • [Transliterated title] L'angiofibrome nasopharyngien avec extension intracrânienne : place de l'association chimiothérapie-radiothérapie.
  • Nasopharyngeal angiofibroma is a locally aggressive, although histologically benign, vascular neoplasm.
  • Surgery is considered as the primary treatment of nasopharyngeal angiofibroma.
  • We report a rare case of nasopharyngeal angiofibroma, further complicated with a Kennedy syndrome in a 34 year-old women.
  • We discuss the relevance and outcome of the association chemotherapy-radiotherapy in the treatment of nasopharyngeal angiofibromas with a consistent intracranial extension (stage III B of Arch Otolaryngol Head Neck Surg 122 (2003) 122-129).
  • [MeSH-major] Angiofibroma / drug therapy. Angiofibroma / radiotherapy. Brain Neoplasms / radiotherapy. Nasopharyngeal Neoplasms / drug therapy. Nasopharyngeal Neoplasms / radiotherapy

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  • (PMID = 18339570.001).
  • [ISSN] 1278-3218
  • [Journal-full-title] Cancer radiothérapie : journal de la Société française de radiothérapie oncologique
  • [ISO-abbreviation] Cancer Radiother
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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100. Ferreira S, Nogueira C, Ferreira D, Neves S, Taveira N: [Tuberous sclerosis with pulmonary involvment]. Rev Port Pneumol; 2010 Mar-Apr;16(2):339-44
MedlinePlus Health Information. consumer health - Tuberous Sclerosis.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Tuberous sclerosis (TS) is a rare, sporadic or autosomal dominant disease characterized by the triad of seizures, mental retardation and angiofibromas.
  • We report the case of a 52 year -old female, nonsmoker, with a history of seizures in childhood and renal angiomyolipomas.
  • Chest CT performed for the evaluation of the disease detected thin-walled pulmonary cysts in both lungs.
  • [MeSH-major] Lung Diseases / etiology. Tuberous Sclerosis / complications

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  • (PMID = 20437010.001).
  • [ISSN] 2172-6825
  • [Journal-full-title] Revista portuguesa de pneumologia
  • [ISO-abbreviation] Rev Port Pneumol
  • [Language] por
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Portugal
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