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1. Kawaoka J, McBean J, Li H, Mihm MC Jr, Kroumpouzos G: Coexistence of diffuse reactive angioendotheliomatosis and neutrophilic dermatosis heralding primary antiphospholipid syndrome. Acta Derm Venereol; 2008;88(4):402-3
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  • [Title] Coexistence of diffuse reactive angioendotheliomatosis and neutrophilic dermatosis heralding primary antiphospholipid syndrome.


2. del Pozo J, Martínez W, Sacristán F, Rodríguez-Lozano J, Fonseca E: Reactive angioendotheliomatosis associated with myelodysplastic syndrome. Acta Derm Venereol; 2005;85(3):269-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Reactive angioendotheliomatosis associated with myelodysplastic syndrome.
  • [MeSH-major] Hemangioendothelioma / diagnosis. Myelodysplastic Syndromes / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged. Cold Temperature. Diagnosis, Differential. Ear. Humans. Male


3. Takahashi T, Minato M, Tsukuda H, Yoshimoto M, Tsujisaki M: Successful treatment of intravascular large B-cell lymphoma diagnosed by bone marrow biopsy and FDG-PET scan. Intern Med; 2008;47(10):975-9
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  • [Title] Successful treatment of intravascular large B-cell lymphoma diagnosed by bone marrow biopsy and FDG-PET scan.
  • Early diagnosis of intravascular large B-cell lymphoma (IVLBCL) is difficult, but is critical for longer survival for the patients.
  • She presented with general malaise and high fever.
  • A diagnosis of IVLBCL was made by bone marrow biopsy.
  • [MeSH-major] Bone Marrow Examination. Fluorodeoxyglucose F18. Lymphoma, Large B-Cell, Diffuse / diagnosis. Lymphoma, Large B-Cell, Diffuse / drug therapy. Positron-Emission Tomography

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  • (PMID = 18480585.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0Z5B2CJX4D / Fluorodeoxyglucose F18; 4F4X42SYQ6 / Rituximab; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CHOP protocol, modified
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4. Mensing CH, Krengel S, Tronnier M, Wolff HH: Reactive angioendotheliomatosis: is it 'intravascular histiocytosis'? J Eur Acad Dermatol Venereol; 2005 Mar;19(2):216-9
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  • [Title] Reactive angioendotheliomatosis: is it 'intravascular histiocytosis'?
  • We report the case of a 68-year-old female with reactive angioendotheliomatosis (RAE).
  • This case highlights the benign course of this condition and suggests that this entity might be an intravascular histiocytosis.
  • [MeSH-major] Endothelium, Vascular / pathology. Histiocytosis / pathology. Lymphoma, Non-Hodgkin / pathology. Skin Neoplasms / pathology

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  • (PMID = 15752295.001).
  • [ISSN] 0926-9959
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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5. Fuji RN, Patton KM, Steinbach TJ, Schulman FY, Bradley GA, Brown TT, Wilson EA, Summers BA: Feline systemic reactive angioendotheliomatosis: eight cases and literature review. Vet Pathol; 2005 Sep;42(5):608-17
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  • [Title] Feline systemic reactive angioendotheliomatosis: eight cases and literature review.
  • A rare, multisystemic intravascular proliferative disorder was identified postmortem in eight cats.
  • Immunohistochemically, the majority of intravascular cells expressed von Willebrand factor, and a smaller number expressed smooth muscle actin, compatible with a dual population of endothelial cells and pericytes, suggesting a reactive rather than a neoplastic process.
  • Four cases of a similar feline vascular disorder from the veterinary literature are reviewed.
  • The histopathology resembles reactive angioendotheliomatosis in humans, a benign cutaneous intravascular endothelial and pericytic proliferative condition.
  • We propose the name "feline systemic reactive angioendotheliomatosis" for this unique, idiopathic disorder of domestic cats.

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  • (PMID = 16145207.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 37
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6. Clarke LE, Julian KG, Clarke JT, Ioffreda MD: Reactive angioendotheliomatosis in association with a well-differentiated angiosarcoma. Am J Dermatopathol; 2005 Oct;27(5):422-7
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  • [Title] Reactive angioendotheliomatosis in association with a well-differentiated angiosarcoma.
  • A 55-year-old white female with a complex medical history including mixed connective tissue disease and peripheral vascular disease developed a group of red-purple papules on her proximal medial thigh that was followed, five months later, by the development of a large violaceous patch.
  • She was admitted to the hospital with a presumptive diagnosis of cellulitis, but failed to respond to antibiotics.
  • A biopsy was performed and demonstrated a well-differentiated angiosarcoma arising in conjunction with reactive angioendotheliomatosis.
  • [MeSH-minor] Cellulitis / diagnosis. Cellulitis / pathology. Diagnosis, Differential. Female. Humans. Melanoma / pathology. Melanoma / radiotherapy. Middle Aged. Mixed Connective Tissue Disease / complications. Neoplasms, Radiation-Induced / pathology. Peripheral Vascular Diseases / complications


7. Shimada K, Kosugi H, Narimatsu H, Shimada S, Suzuki T, Ito M, Kinoshita T, Mori N, Naoe T: Sustained remission after rituximab-containing chemotherapy for intravascular large B-cell lymphoma. J Clin Exp Hematop; 2008 Apr;48(1):25-8
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  • [Title] Sustained remission after rituximab-containing chemotherapy for intravascular large B-cell lymphoma.
  • Intravascular large B-cell lymphoma (IVL) is rare aggressive disseminated lymphoma associated with poor outcomes.
  • Rituximab is a novel molecular agent that can reportedly improve outcomes for patients with diffuse large B-cell lymphoma.
  • Definitive diagnosis of IVL was obtained following repeated biopsies of bone marrow.
  • She has remained in complete remission for over 3 years after diagnosis.
  • [MeSH-major] Antibodies, Monoclonal / administration & dosage. Antineoplastic Agents / therapeutic use. Lymphoma, Large B-Cell, Diffuse / drug therapy

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  • (PMID = 18434690.001).
  • [ISSN] 1346-4280
  • [Journal-full-title] Journal of clinical and experimental hematopathology : JCEH
  • [ISO-abbreviation] J Clin Exp Hematop
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antineoplastic Agents; 4F4X42SYQ6 / Rituximab; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CHOP protocol
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8. Sajid RM, Qureshi A: Involvement of bone marrow with intravascular large B-cell lymphoma. Hematol Oncol Stem Cell Ther; 2010;3(1):39-41

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  • [Title] Involvement of bone marrow with intravascular large B-cell lymphoma.
  • Intravascular large B-cell lymphoma (IVLBCL) is a rare subtype of extranodal large B-cell lymphoma characterized by a selective proliferation of lymphoma cells within the lumina of vessels.
  • The diagnosis of IVLBCL was confirmed on a bone trephine biopsy that revealed positivity of CD20 and PAX5 immunohistochemical staining of lymphoma cells confined within the lumina of vessels.
  • [MeSH-major] Bone Marrow / pathology. Lymphoma, Large B-Cell, Diffuse / pathology. Vascular Neoplasms / pathology
  • [MeSH-minor] Aged, 80 and over. Antigens, CD20 / analysis. B-Cell-Specific Activator Protein / analysis. Fatal Outcome. Humans. Male

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  • (PMID = 20231812.001).
  • [ISSN] 1658-3876
  • [Journal-full-title] Hematology/oncology and stem cell therapy
  • [ISO-abbreviation] Hematol Oncol Stem Cell Ther
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Saudi Arabia
  • [Chemical-registry-number] 0 / Antigens, CD20; 0 / B-Cell-Specific Activator Protein; 0 / PAX5 protein, human
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9. Misago N, Yonekura N, Kuroiwa T, Yamanaka K, Narisawa Y: Simultaneous occurrence of reactive angioendotheliomatosis and leukocytoclastic vasculitis in a patient with periodontitis. Eur J Dermatol; 2008 Mar-Apr;18(2):193-4
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  • [Title] Simultaneous occurrence of reactive angioendotheliomatosis and leukocytoclastic vasculitis in a patient with periodontitis.
  • [MeSH-major] Hand Dermatoses / diagnosis. Periodontitis / diagnosis. Vasculitis / diagnosis
  • [MeSH-minor] Aged. Anti-Inflammatory Agents / administration & dosage. Anti-Inflammatory Agents / therapeutic use. Anti-Inflammatory Agents, Non-Steroidal / administration & dosage. Anti-Inflammatory Agents, Non-Steroidal / therapeutic use. Aspirin / administration & dosage. Aspirin / therapeutic use. Betamethasone / administration & dosage. Betamethasone / therapeutic use. Dental Care. Diagnosis, Differential. Drug Therapy, Combination. Female. Humans. Thigh / pathology

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  • (PMID = 18424386.001).
  • [ISSN] 1167-1122
  • [Journal-full-title] European journal of dermatology : EJD
  • [ISO-abbreviation] Eur J Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 0 / Anti-Inflammatory Agents, Non-Steroidal; 9842X06Q6M / Betamethasone; R16CO5Y76E / Aspirin
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10. Aguayo-Leiva I, Vano-Galván S, Salguero I, Carrillo-Gijón R, Vallés A, Herrera P, Muñoz-Zato E: Reactive angioendotheliomatosis in a patient with Myelodysplastic Syndrome presenting as a cellulitis-like plaque. Eur J Dermatol; 2009 Mar-Apr;19(2):182-3
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  • [Title] Reactive angioendotheliomatosis in a patient with Myelodysplastic Syndrome presenting as a cellulitis-like plaque.
  • [MeSH-major] Hemangioendothelioma / diagnosis. Myelodysplastic Syndromes / complications. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged. Cellulitis / diagnosis. Forearm. Humans. Male


11. Breshears MA, Johnson BJ: Systemic reactive angioendotheliomatosis-like syndrome in a steer presumed to be persistently infected with bovine viral diarrhea virus. Vet Pathol; 2008 Sep;45(5):645-9
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  • [Title] Systemic reactive angioendotheliomatosis-like syndrome in a steer presumed to be persistently infected with bovine viral diarrhea virus.
  • Unusual proliferative intravascular lesions were seen in multiple organs of a 2-year-old Corriente steer presumed to be persistently infected with bovine viral diarrhea virus (BVDV), based on widespread immunohistochemical detection of BVDV antigen.
  • Distribution and character of the intraluminal proliferations are strikingly similar to those described in feline systemic reactive angioendotheliomatosis, a rare entity of unknown cause.
  • The presence of occasional intravascular thrombi suggests that the proliferative vasculopathy was associated with an underlying thrombotic process with immunohistochemical similarities to thrombotic thrombocytopenic purpura of humans.
  • The role of persistent BVDV infection in the formation of the intravascular lesions is unknown.

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  • (PMID = 18725468.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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12. Kirke S, Angus B, Kesteven PJ, Calonje E, Simpson N: Localized reactive angioendotheliomatosis. Clin Exp Dermatol; 2007 Jan;32(1):45-7
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  • [Title] Localized reactive angioendotheliomatosis.
  • Further investigation revealed a very high anticardiolipin IgG titre and a left subclavian stenosis, presumably providing the reduced blood flow and relative hypoxia to allow microthromboses to occur in the presence of a thrombophilic tendency.
  • Similar clinical and histological features have been reported in patients with the antiphospholipid syndrome and cases of reactive angioendotheliomatosis (RAE).

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  • (PMID = 17004988.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Anticardiolipin
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13. Requena L, El-Shabrawi-Caelen L, Walsh SN, Segura S, Ziemer M, Hurt MA, Sangüeza OP, Kutzner H: Intralymphatic histiocytosis. A clinicopathologic study of 16 cases. Am J Dermatopathol; 2009 Apr;31(2):140-51
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  • Although its pathogenesis remains uncertain, there has been speculation about the possible relationship between intralymphatic histiocytosis and intravascular reactive angioendotheliomatosis.
  • Our findings expand on the previously described morphologic and immunohistochemical features of intravascular histiocytosis.
  • We also discuss the possible relationship between intralymphatic histiocytosis and the so-called reactive intravascular angioendotheliomatosis.

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  • (PMID = 19318799.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Membrane Glycoproteins; 0 / PDPN protein, human; EC 5.4.2.2 / PGM1 protein, human; EC 5.4.2.2 / Phosphoglucomutase
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14. Miyazaki K, Yamaguchi M, Suzuki R, Niitsu N, Ennishi D, Tamaru J, Kagami Y, Katayama N, Kinoshita T, Nakamura S: Retrospective analysis of CD5-positive diffuse large B-cell lymphoma (CD5+ DLBCL) treated with chemotherapy with or without rituximab. J Clin Oncol; 2009 May 20;27(15_suppl):8551

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  • [Title] Retrospective analysis of CD5-positive diffuse large B-cell lymphoma (CD5+ DLBCL) treated with chemotherapy with or without rituximab.
  • : 8551 Background: CD5+ DLBCL comprises 5-10% of DLBCL, and shows a high incidence of central nervous system (CNS) relapse.
  • Intravascular large B-cell lymphoma, primary CNS DLBCL, and secondary CD5+ DLBCL were excluded from the study population.
  • Pts treated without rituximab received more dose-intensive chemotherapies (CHOP14, third-generation regimen, and high dose cytarabine-based regimen) than those treated with rituximab (24% vs. 7%, P<0.0001).

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  • (PMID = 27960955.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. Agusti A, Hernández P, Oliver V, García R, Alegre de Miquel V: [Angioendotheliomatosis associated with chronic venous insufficiency]. Actas Dermosifiliogr; 2010 Jun;101(5):464-6

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  • [Title] [Angioendotheliomatosis associated with chronic venous insufficiency].
  • [Transliterated title] Angioendoteliomatosis reactiva asociada a insuficiencia venosa crónica.

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  • (PMID = 20525497.001).
  • [ISSN] 1578-2190
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Spain
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16. Echeverría-García B, Botella-Estrada R, Requena C, Guillén C: [Intralymphatic histiocytosis and cancer of the colon]. Actas Dermosifiliogr; 2010 Apr;101(3):257-62
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  • [Transliterated title] Histiocitosis intralinfática y neoplasia de colon.
  • In the past, the majority of these cases were thought to be cases of reactive angioendotheliomatosis or intravascular lymphoma, but the development of more specific immunohistochemical markers showed that these were dilated lymph vessels containing histiocytes, and so were considered as a separate condition.

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  • (PMID = 20398602.001).
  • [ISSN] 1578-2190
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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17. Yang H, Ahmed I, Mathew V, Schroeter AL: Diffuse dermal angiomatosis of the breast. Arch Dermatol; 2006 Mar;142(3):343-7
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  • [Title] Diffuse dermal angiomatosis of the breast.
  • BACKGROUND: Diffuse dermal angiomatosis is rare and usually considered a variant of reactive angioendotheliomatosis.
  • Two patients with breast involvement have been described; however, neither had a relevant medical history or a vaso-occlusive disorder, but both had large pendulous breasts, and 1 was positive for IgM anticardiolipin and antinuclear antibodies.
  • Biopsy of the lesion showed diffuse proliferation of additional endothelial cells and small bland vessels within the papillary and upper reticular dermis.
  • Diffuse dermal angiomatosis was diagnosed.
  • A literature review suggested that a history of heavy smoking, in addition to a history of vascular disease, may be important in the pathogenesis of diffuse dermal angiomatosis.
  • CONCLUSIONS: Clinical acumen is crucial to diagnose diffuse angiomatosis of the breast.

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  • [CommentIn] Arch Dermatol. 2006 Mar;142(3):362-4 [16549715.001]
  • (PMID = 16549710.001).
  • [ISSN] 0003-987X
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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18. Barnett CR, Seo S, Husain S, Grossman ME: Intravascular B-cell lymphoma: the role of skin biopsy. Am J Dermatopathol; 2008 Jun;30(3):295-9
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  • [Title] Intravascular B-cell lymphoma: the role of skin biopsy.
  • Intravascular B-cell lymphoma is a rare aggressive systemic neoplasm with cutaneous and neurological presentations, which commonly eludes the diagnosis ante mortem.
  • First reported in 1959 as "angioendotheliomatosis proliferans" by Pfleger and Tappeiner, it is a subtype of extranodal diffuse large-B-cell lymphoma defined by an intravascular proliferation of clonal lymphocytes.
  • We describe a case of intravascular lymphoma in a 68-year-old female who presented with altered mental status and indurated, erythematous, ecchymotic plaques with overlying telangiectasia and ulceration.
  • The diagnosis was made by skin biopsy of an abdominal plaque revealing large hyperchromatic cells filling the lumina of several small blood vessels within the dermis and subcutis.
  • CD20 and CD79a immunostains were strongly positive, confirming the diagnosis of intravascular large-B-cell lymphoma.
  • This case illustrates an unusual subtype of extranodal diffuse large-B-cell lymphoma, which demonstrates protean clinical presentations, requires microscopic examination for diagnosis, but can be easily overlooked on skin biopsy.
  • [MeSH-major] Lymphoma, Large B-Cell, Diffuse / pathology. Neoplasms, Vascular Tissue / pathology. Skin / pathology

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  • (PMID = 18496438.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antigens, CD; 0 / Biomarkers, Tumor; 4F4X42SYQ6 / Rituximab; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CHOP protocol
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19. Fukunaga M: Expression of D2-40 in lymphatic endothelium of normal tissues and in vascular tumours. Histopathology; 2005 Apr;46(4):396-402
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  • Ten of 10 cases of lymphangioma, nine of 10 Kaposi's sarcomas (KSs), one of five spindle cell haemangiomas, one of one reactive angioenodotheliomatosis, one of one vascular transformation of lymph node sinuses, three of three Dabska tumours, one of 10 epithelioid haemangioendotheliomas (HEs) and seven of 15 angiosarcomas were positive for D2-40.
  • Twenty-two non-spindle cell haemangiomas, one retiform HE and one Kaposiform HE, and five glomus tumours were negative for D2-40.
  • In comparison, CD31 was expressed in five of 10 lymphangiomas, nine of 10 KSs, 27 of 27 haemangiomas, three of three Dabska tumours, 10 of 10 epithelioid HEs, 15 of 15 angiosarcomas and one of one each of retiform HE, Kaposiform HE, reactive angioendotheliomatosis, and vascular transformation of node sinuses.
  • [MeSH-minor] Antibodies, Monoclonal, Murine-Derived. Antigens, CD31 / analysis. Antigens, Neoplasm / immunology. Humans. Immunohistochemistry. Lymphatic System

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  • (PMID = 15810951.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antigens, CD31; 0 / Antigens, Neoplasm; 0 / monoclonal antibody D2-40; 0 / oncofetal antigens
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20. Marini-Bettolo C, Lane R, Charles P, Naresh K, Nicholas R, Singh P, Cohen A, Mackie P, Roncaroli F: Myopathy secondary to intravascular large B-cell lymphoma. Neuromuscul Disord; 2009 Dec;19(12):856-9
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  • [Title] Myopathy secondary to intravascular large B-cell lymphoma.
  • We report a case of a 78-year-old woman presenting with progressive proximal muscle weakness mainly to lower limbs and myopathic EMG associated with intravascular large B-cell lymphoma.
  • Muscle biopsy showed myopathic changes, intravascular large B-cell lymphoma but no inflammation or fibre necrosis; the patient's serum cross-reacted with an unidentified nuclear antigen of approximately 45 kDa present in muscle and lymphoma cells.
  • Our case illustrates a myopathy associated with intravascular large B-cell lymphoma probably mediated by antibodies cross-reacting with a nuclear protein expressed by neoplastic cells and normal muscle.
  • [MeSH-major] Lymphoma, Large B-Cell, Diffuse / complications. Muscular Diseases / etiology

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  • (PMID = 19793654.001).
  • [ISSN] 1873-2364
  • [Journal-full-title] Neuromuscular disorders : NMD
  • [ISO-abbreviation] Neuromuscul. Disord.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Nuclear Proteins
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21. Higashiyama A, Hashino S, Onozawa M, Takahata M, Okada K, Kahata K, Taniguchi N, Nasuhara Y, Kubota K, Fujimoto N, Matsuno Y, Nishimura M, Asaka M: [Intravascular large B-cell lymphoma with massive pulmonary lesions]. Rinsho Ketsueki; 2010 May;51(5):353-6
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  • [Title] [Intravascular large B-cell lymphoma with massive pulmonary lesions].
  • The TBLB specimen was diagnosed as intravascular large B-cell lymphoma (IVLBCL).
  • In cases showing clinical findings such as hypoxia despite mild pulmonary radiographic changes, a definitive diagnosis should be made using methods such as TBLB with consideration given to the possibility of IVLBCL.
  • [MeSH-major] Lung Neoplasms / diagnosis. Lymphoma, Large B-Cell, Diffuse / diagnosis. Vascular Neoplasms / diagnosis. Vascular Neoplasms / pathology

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  • (PMID = 20534958.001).
  • [ISSN] 0485-1439
  • [Journal-full-title] [Rinshō ketsueki] The Japanese journal of clinical hematology
  • [ISO-abbreviation] Rinsho Ketsueki
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 4F4X42SYQ6 / Rituximab; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; 9PHQ9Y1OLM / Prednisolone; VAP-cyclo protocol
  • [Number-of-references] 5
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22. Kato M, Ohshima K, Mizuno M, Kyogoku M, Hashikawa K, Tokura Y, Miyachi Y, Kabashima K: Analysis of CXCL9 and CXCR3 expression in a case of intravascular large B-cell lymphoma. J Am Acad Dermatol; 2009 Nov;61(5):888-91
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  • [Title] Analysis of CXCL9 and CXCR3 expression in a case of intravascular large B-cell lymphoma.
  • Intravascular large B-cell lymphoma is a rare disease with multiorgan involvement that also affects the skin.
  • We report a 68-year-old woman with bilateral leg edema and occasional high fever.
  • A biopsy specimen from a subcutaneous nodule showed that the blood vessels in the dermis and subcutaneous tissue were filled with irregularly shaped chromatin-rich large atypical lymphocytes positive for CD20 and bcl-2, consistent with the diagnosis of intravascular large B-cell lymphoma.
  • Although limited to a single case, our study could provide a possible new clue to the pathogenesis of intravascular large B-cell lymphoma by virtue of the characteristic expression of CXCL9-CXCR3.
  • [MeSH-major] Chemokine CXCL9 / metabolism. Lymphoma, Large B-Cell, Diffuse / metabolism. Lymphoma, Large B-Cell, Diffuse / pathology. Receptors, CXCR3 / metabolism. Vascular Neoplasms / metabolism. Vascular Neoplasms / pathology

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  • (PMID = 19766346.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CXCL9 protein, human; 0 / CXCR3 protein, human; 0 / Chemokine CXCL9; 0 / Receptors, CXCR3
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23. Le EN, Gerstenblith MR, Gelber AC, Manno RL, Ranasinghe PD, Sweren RJ, McGirt LY: The use of blind skin biopsy in the diagnosis of intravascular B-cell lymphoma. J Am Acad Dermatol; 2008 Jul;59(1):148-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The use of blind skin biopsy in the diagnosis of intravascular B-cell lymphoma.
  • Intravascular B-cell lymphoma is a rare type of non-Hodgkin's lymphoma that is characterized by a clonal proliferation of lymphoblasts within small blood vessels.
  • Patients present with nonspecific symptoms and are often only given a diagnosis at autopsy.
  • We report a case of intravascular B-cell lymphoma, characterized by pyrexia, anemia, thrombocytopenia, and mental status decline, without obvious cutaneous manifestations, that was diagnosed with blind skin biopsy.
  • [MeSH-major] Lymphoma, B-Cell / pathology. Skin / pathology. Vascular Neoplasms / pathology

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  • (PMID = 18406005.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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24. Zhao XF, Sands AM, Ostrow PT, Halbiger R, Conway JT, Bagg A: Recurrence of nodal diffuse large B-cell lymphoma as intravascular large B-cell lymphoma: is an intravascular component at initial diagnosis predictive? Arch Pathol Lab Med; 2005 Mar;129(3):391-4
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  • [Title] Recurrence of nodal diffuse large B-cell lymphoma as intravascular large B-cell lymphoma: is an intravascular component at initial diagnosis predictive?
  • We report a case of a 59-year-old man who first presented with a nodal diffuse large B-cell lymphoma that later relapsed as an intravascular large B-cell lymphoma.
  • In the initial biopsy specimen, a few intranodal small vessels that contained large lymphoma cells were noted.
  • Two years after the initial diagnosis of nodal diffuse large B-cell lymphoma, the patient presented with a rapid onset of multiorgan failure, which at autopsy was shown to be due to intravascular large B-cell lymphoma.
  • To our knowledge, this is the first report of a nodal large B-cell lymphoma that relapsed as an intravascular large B-cell lymphoma.
  • Although this report is of only a single case, the presence of a relatively inconspicuous intravascular component in an otherwise typical nodal large B-cell lymphoma may be predictive and could affect clinical decisions regarding diagnosis, monitoring, and prognosis of such lymphomas.
  • [MeSH-major] Lymphoma, B-Cell / diagnosis. Lymphoma, Large B-Cell, Diffuse / diagnosis. Neoplasm Recurrence, Local / diagnosis. Vascular Neoplasms / diagnosis

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  • (PMID = 15737037.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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25. Anda T, Haraguchi W, Miyazato H, Tanaka S, Ishihara T, Aozasa K, Nakamichi I: Ruptured distal middle cerebral artery aneurysm filled with tumor cells in a patient with intravascular large B-cell lymphoma. J Neurosurg; 2008 Sep;109(3):492-6
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  • [Title] Ruptured distal middle cerebral artery aneurysm filled with tumor cells in a patient with intravascular large B-cell lymphoma.
  • The authors describe a very rare case of intravascular large B-cell lymphoma in a woman whose ruptured distal middle cerebral artery (MCA) aneurysms were filled with lymphoma cells.
  • Based on the histological examination of the resected aneurysms, proliferation of large B-cell lymphoma was identified in the dilated arterial lumen.
  • Postmortem examination revealed similar lymphoma cells only in the intimal layer that had grown on the artificial graft, and it was decided that the patient had had intravascular large B-cell lymphoma.
  • For patients with incomprehensible ischemic cerebral stroke, neoplasm must be taken in consideration.
  • [MeSH-major] Aneurysm, Ruptured / pathology. Intracranial Aneurysm / pathology. Lymphoma, Large B-Cell, Diffuse / pathology

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  • (PMID = 18759582.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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26. Pallure V, Dandurand M, Stoebner PE, Habib F, Colonna G, Meunier L: [Intravascular B-cell lymphoma with febrile inflammatory lymphoedema of the lower limbs and lower back]. Ann Dermatol Venereol; 2008 Apr;135(4):299-303
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  • [Title] [Intravascular B-cell lymphoma with febrile inflammatory lymphoedema of the lower limbs and lower back].
  • [Transliterated title] Lymphome B intravasculaire à type de lymphoedème inflammatoire fébrile des membres inférieurs et des lombes.
  • BACKGROUND: Intravascular lymphomas are diffuse large-cell lymphomas belonging to a group of high-grade non-Hodgkin's lymphomas and are generally of phenotype B.
  • PATIENTS AND METHODS: We report the case of an 80-year-old woman with cutaneous intravascular B-cell lymphoma as revealed by an isolated episode of febrile bilateral inflammatory lymphoedema.
  • DISCUSSION: Diagnosis of these tumours is rendered difficult by the clinical polymorphism and multifocal nature of lymphocytic proliferations.
  • In the present case, diagnosis was based on histology results since presentation of the disease in the form of bilateral inflammatory oedema of the lower limbs is not sufficient to establish lymphoma.
  • [MeSH-major] Lymphedema / complications. Lymphedema / pathology. Lymphoma, B-Cell / complications

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  • (PMID = 18420078.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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27. Ferreri AJ, Dognini GP, Bairey O, Szomor A, Montalbán C, Horvath B, Demeter J, Uziel L, Soffietti R, Seymour JF, Ambrosetti A, Willemze R, Martelli M, Rossi G, Candoni A, De Renzo A, Doglioni C, Zucca E, Cavalli F, Ponzoni M, International Extranodal Lymphoma Study Group: The addition of rituximab to anthracycline-based chemotherapy significantly improves outcome in 'Western' patients with intravascular large B-cell lymphoma. Br J Haematol; 2008 Oct;143(2):253-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The addition of rituximab to anthracycline-based chemotherapy significantly improves outcome in 'Western' patients with intravascular large B-cell lymphoma.
  • Some case reports and a Japanese series suggest benefit from the use of rituximab in patients with intravascular large B-cell lymphoma (IVL).
  • [MeSH-major] Anthracyclines / therapeutic use. Antibodies, Monoclonal / therapeutic use. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Immunologic Factors / therapeutic use. Lymphoma, Large B-Cell, Diffuse / drug therapy. Vascular Neoplasms / drug therapy

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  • (PMID = 18699850.001).
  • [ISSN] 1365-2141
  • [Journal-full-title] British journal of haematology
  • [ISO-abbreviation] Br. J. Haematol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anthracyclines; 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Immunologic Factors; 4F4X42SYQ6 / Rituximab; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CHOP protocol
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28. Monteiro M, Duarte I, Cabeçadas J, Orvalho ML: Intravascular large B-cell lymphoma of the breast. Breast; 2005 Feb;14(1):75-8
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  • [Title] Intravascular large B-cell lymphoma of the breast.
  • The case of an 80-year-old woman with symmetrical breast engorgement and nonspecific systemic symptoms progressively developing over 3 months and confirmed on surgical biopsy to be due to an intravascular large B-cell lymphoma (ILBCL) is presented.
  • [MeSH-major] Breast Neoplasms / pathology. Lymphoma, B-Cell / pathology. Lymphoma, Large B-Cell, Diffuse / pathology

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  • (PMID = 15695087.001).
  • [ISSN] 0960-9776
  • [Journal-full-title] Breast (Edinburgh, Scotland)
  • [ISO-abbreviation] Breast
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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29. Shimada K, Kosugi H, Shimada S, Narimatsu H, Koyama Y, Suzuki N, Yuge M, Nishibori H, Iwata Y, Nakamura S, Naoe T, Kinoshita T: Evaluation of organ involvement in intravascular large B-cell lymphoma by 18F-fluorodeoxyglucose positron emission tomography. Int J Hematol; 2008 Sep;88(2):149-53

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Evaluation of organ involvement in intravascular large B-cell lymphoma by 18F-fluorodeoxyglucose positron emission tomography.
  • To evaluate the role of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) in intravascular large B-cell lymphoma (IVLBCL), we retrospectively analyzed four consecutive IVLBCL patients receiving FDG-PET before treatment between May 2006 and November 2007.
  • All patients received bone marrow biopsies and random skin biopsies and two of the four patients underwent renal biopsy for diagnosis.
  • One patient with a false-negative FDG-PET result showed fewer lymphoma cells in the bone marrow specimen than patients with concordant FDG-PET results.
  • [MeSH-major] Kidney / diagnostic imaging. Lymphoma, Large B-Cell, Diffuse / diagnostic imaging. Positron-Emission Tomography / methods. Positron-Emission Tomography / standards. Skin / diagnostic imaging

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  • [Cites] J Clin Oncol. 2007 Jul 20;25(21):3168-73 [17577023.001]
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  • (PMID = 18496649.001).
  • [ISSN] 0925-5710
  • [Journal-full-title] International journal of hematology
  • [ISO-abbreviation] Int. J. Hematol.
  • [Language] eng
  • [Publication-type] Journal Article; Validation Studies
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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30. Sur M, Ross C, Moens F, Daya D: Intravascular large B-cell lymphoma of the uterus: a diagnostic challenge. Int J Gynecol Pathol; 2005 Apr;24(2):201-3
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  • [Title] Intravascular large B-cell lymphoma of the uterus: a diagnostic challenge.
  • The initial curettage material was reported as "undifferentiated malignant tumor."
  • A total abdominal hysterectomy with bilateral salpingo-oophorectomy was performed with pelvic lymph node dissection and omental biopsy, which showed an intravascular large B-cell lymphoma in the lumina of small blood vessels of the uterus, left tube, and right ovary.
  • This is the first reported case of an intravascular lymphoma of the uterus.
  • [MeSH-major] Lymphoma, B-Cell / pathology. Lymphoma, Large B-Cell, Diffuse / pathology. Uterine Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Immunohistochemistry. Middle Aged

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  • (PMID = 15782078.001).
  • [ISSN] 0277-1691
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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31. Tadokoro J, Arai Y, Tokita K, Iso H, Nakamura Y, Maki K, Sasaki K, Mitani K: [Asian variant of intravascular large B-cell lymphoma diagnosed by bone marrow biopsy]. Rinsho Ketsueki; 2007 Jan;48(1):61-3
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  • [Title] [Asian variant of intravascular large B-cell lymphoma diagnosed by bone marrow biopsy].
  • Histological analysis of the bone marrow biopsy specimen demonstrated proliferation of atypical lymphoid cells positive for CD20 in the small capillaries, leading to the diagnosis of the Asian variant of intravascular large B-cell lymphoma (AIVL).
  • The presence of rearrangement of the immunoglobulin gene confirmed the diagnosis.
  • [MeSH-major] Bone Marrow / pathology. Lymphoma, B-Cell / diagnosis. Lymphoma, Large B-Cell, Diffuse / diagnosis. Vascular Neoplasms / diagnosis

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  • (PMID = 17313078.001).
  • [ISSN] 0485-1439
  • [Journal-full-title] [Rinshō ketsueki] The Japanese journal of clinical hematology
  • [ISO-abbreviation] Rinsho Ketsueki
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antigens, CD20; 4F4X42SYQ6 / Rituximab; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CHOP protocol
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32. Xanthopoulos V, Galanopoulos AG, Paterakis G, Apessou D, Argyrakos T, Goumakou E, Papadhimitriou SI, Savvidou I, Georgiakaki M, Anagnostopoulos NI: Intravascular B-cell lymphoma with leukemic presentation: case report and literature review. Eur J Haematol; 2008 Feb;80(2):177-81
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  • [Title] Intravascular B-cell lymphoma with leukemic presentation: case report and literature review.
  • Intravascular lymphoma is an extremely rare, disseminated, and aggressive extranodal CD20+ non-Hodgkin's lymphoma characterized by the presence of lymphoma cells only in the lumina of small vessels.
  • We report a 72-year-old woman with a diagnosis of intravascular lymphoma presented with splenomegaly and leukemic appearance in the peripheral blood smear.
  • Bone marrow biopsy revealed a characteristic infiltration of CD5, CD10 B-cell lymphoma.
  • To our knowledge, this is the first reported case of a CD5, CD10 intravascular B-cell lymphoma with leukemic presentation in peripheral blood with multiple cytogenetic aberrations.
  • [MeSH-major] Leukemia / complications. Lymphoma, Large B-Cell, Diffuse / complications

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  • (PMID = 18076638.001).
  • [ISSN] 1600-0609
  • [Journal-full-title] European journal of haematology
  • [ISO-abbreviation] Eur. J. Haematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD20; 0 / Antigens, CD34; 0 / Antigens, CD5; EC 3.4.24.11 / Neprilysin
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33. Lannoo L, Smets S, Steenkiste E, Delforge M, Moerman P, Stroobants S, Knockaert D, Amant F: Intravascular large B-cell lymphoma of the uterus presenting as fever of unknown origin (FUO) and revealed by FDG-PET. Acta Clin Belg; 2007 May-Jun;62(3):187-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intravascular large B-cell lymphoma of the uterus presenting as fever of unknown origin (FUO) and revealed by FDG-PET.
  • Non-Hodgkin's lymphoma (NHL) is a common cause of Fever of Unknown Origin (FUO) but the presentation as a gynaecologic malignancy is exceedingly rare.
  • To our knowledge, this represents the first report of an intravascular large B-cell lymphoma of the uterus presenting with fever of unknown origin.
  • After a standard clinical work-up for FUO, the endometrial curettage directed by the finding of a localized fluoro-deoxyglucose Positron Emission Tomography (FDG-PET) hot spot in the pelvic area, yielded material revealing an intr avascular B-cell lymphoma.
  • A total abdominal hysterectomy confirmed the presence of an intravascular large B-cell lymphoma in the lumina of small blood vessels of the uterus.
  • [MeSH-major] Fever of Unknown Origin / etiology. Lymphoma, B-Cell / radionuclide imaging. Lymphoma, Large B-Cell, Diffuse / radionuclide imaging. Positron-Emission Tomography. Uterine Neoplasms / radionuclide imaging. Uterus / blood supply. Vascular Neoplasms / radionuclide imaging

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  • (PMID = 17672184.001).
  • [ISSN] 1784-3286
  • [Journal-full-title] Acta clinica Belgica
  • [ISO-abbreviation] Acta Clin Belg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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34. Deisch J, Fuda FB, Chen W, Karandikar N, Arbini AA, Zhou XJ, Wang HY: Segmental tandem triplication of the MLL gene in an intravascular large B-cell lymphoma with multisystem involvement: a comprehensive morphologic, immunophenotypic, cytogenetic, and molecular cytogenetic antemortem study. Arch Pathol Lab Med; 2009 Sep;133(9):1477-82
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  • [Title] Segmental tandem triplication of the MLL gene in an intravascular large B-cell lymphoma with multisystem involvement: a comprehensive morphologic, immunophenotypic, cytogenetic, and molecular cytogenetic antemortem study.
  • An association between intravascular large B-cell lymphoma (IVLBCL) and the mixed lineage leukemia (MLL) gene has never been demonstrated.
  • [MeSH-major] Chromosomes, Human, Pair 11 / genetics. Lymphoma, Large B-Cell, Diffuse / genetics. Myeloid-Lymphoid Leukemia Protein / genetics. Tandem Repeat Sequences / genetics. Trisomy / genetics

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  • (PMID = 19722759.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Biomarkers, Tumor; 0 / MLL protein, human; 149025-06-9 / Myeloid-Lymphoid Leukemia Protein; 4F4X42SYQ6 / Rituximab; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; EC 2.1.1.43 / Histone-Lysine N-Methyltransferase; VB0R961HZT / Prednisone; CHOP protocol
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35. Shimada K, Matsue K, Yamamoto K, Murase T, Ichikawa N, Okamoto M, Niitsu N, Kosugi H, Tsukamoto N, Miwa H, Asaoku H, Kikuchi A, Matsumoto M, Saburi Y, Masaki Y, Yamaguchi M, Nakamura S, Naoe T, Kinoshita T: Retrospective analysis of intravascular large B-cell lymphoma treated with rituximab-containing chemotherapy as reported by the IVL study group in Japan. J Clin Oncol; 2008 Jul 1;26(19):3189-95
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  • [Title] Retrospective analysis of intravascular large B-cell lymphoma treated with rituximab-containing chemotherapy as reported by the IVL study group in Japan.
  • PURPOSE: To evaluate the safety and efficacy of rituximab-containing chemotherapies for intravascular large B-cell lymphoma (IVLBCL).
  • The International Prognostic Index was high-intermediate/high in 97% of patients.
  • Progression-free survival (PFS) and overall survival (OS) rates at 2 years after diagnosis were significantly higher for patients in the R-chemotherapy group (PFS, 56%; OS, 66%) than for patients in the chemotherapy group (PFS, 27% with P = .001; OS, 46% with P = 0.01).
  • [MeSH-major] Antibodies, Monoclonal / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Lymphoma, B-Cell / drug therapy

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  • [CommentIn] J Clin Oncol. 2008 Nov 1;26(31):5134-6; author reply 5136-7 [18838697.001]
  • (PMID = 18506023.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 4F4X42SYQ6 / Rituximab
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36. Ohshima R, Tomita N, Motohashi K, Ieda A, Hyou R, Fujisawa S, Fujita H, Sakai R, Koharazawa H, Kuwabara H, Kanamori H, Ishigatsubo Y: [Clinical course of 8 patients with intravascular large B-cell lymphoma diagnosed while alive]. Rinsho Ketsueki; 2005 Jun;46(6):453-7
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  • [Title] [Clinical course of 8 patients with intravascular large B-cell lymphoma diagnosed while alive].
  • We retrospectively evaluated the diagnosis and clinical courses of 8 patients with intravascular large B-cell lymphoma (IVL) diagnosed while they were alive.
  • Most complaints at diagnosis were fever or dyspnea.
  • The diagnosis of IVL was confirmed by biopsy specimens from the bone marrow in 4, lung in 2, muscle, adrenal gland, and lymph node in 1 case, respectively.
  • In suspicious cases, it is important to bear IVL in mind and examine bone marrow biopsies for an early diagnosis.
  • [MeSH-major] Lymphoma, B-Cell / diagnosis. Lymphoma, Large B-Cell, Diffuse / diagnosis. Vascular Neoplasms / diagnosis
  • [MeSH-minor] Aged. Aged, 80 and over. Antibodies, Monoclonal / administration & dosage. Antibodies, Monoclonal, Murine-Derived. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bone Marrow / pathology. Early Diagnosis. Female. Humans. Male. Middle Aged. Neoplasm Staging. Prognosis. Rituximab

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  • (PMID = 16447727.001).
  • [ISSN] 0485-1439
  • [Journal-full-title] [Rinshō ketsueki] The Japanese journal of clinical hematology
  • [ISO-abbreviation] Rinsho Ketsueki
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 4F4X42SYQ6 / Rituximab
  • [Number-of-references] 17
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37. Nakazato T, Suzuki K, Mihara A, Sanada Y, Yoshida S, Kakimoto T: [Intravascular large B-cell lymphoma with pontine involvement successfully treated with R-hyper-CVAD/R-MTX-Ara-C regimen]. Rinsho Ketsueki; 2010 Feb;51(2):148-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Intravascular large B-cell lymphoma with pontine involvement successfully treated with R-hyper-CVAD/R-MTX-Ara-C regimen].
  • Malignant lymphoma was suspected, but histological diagnosis was difficult because superficial lymph nodes could not be palpated.
  • Histological examination of the bone marrow biopsy specimen demonstrated the proliferation of large atypical lymphoid cells positive for CD20 and CD79a in the small capillaries, leading to the diagnosis of intravascular large B-cell lymphoma (IVLBCL).
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Brain Stem Neoplasms / drug therapy. Brain Stem Neoplasms / pathology. Lymphoma, Large B-Cell, Diffuse / drug therapy. Vascular Neoplasms / drug therapy
  • [MeSH-minor] Cyclophosphamide / administration & dosage. Cytarabine / administration & dosage. Dexamethasone / administration & dosage. Doxorubicin / administration & dosage. Female. Humans. Methotrexate / administration & dosage. Middle Aged. Neoplasm Invasiveness. Remission Induction. Treatment Outcome. Vincristine / administration & dosage

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  • (PMID = 20379108.001).
  • [ISSN] 0485-1439
  • [Journal-full-title] [Rinshō ketsueki] The Japanese journal of clinical hematology
  • [ISO-abbreviation] Rinsho Ketsueki
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 04079A1RDZ / Cytarabine; 5J49Q6B70F / Vincristine; 7S5I7G3JQL / Dexamethasone; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; YL5FZ2Y5U1 / Methotrexate; CVAD protocol
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38. Yago K, Yanagita S, Aono M, Matsuo K, Shimada H: [Usefulness of FDG-PET/CT for the diagnosis of intravascular large B-cell lymphoma presenting with fever of unknown origin and renal dysfunction]. Rinsho Ketsueki; 2009 Jun;50(6):499-502
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  • [Title] [Usefulness of FDG-PET/CT for the diagnosis of intravascular large B-cell lymphoma presenting with fever of unknown origin and renal dysfunction].
  • Based on the imaging study, renal biopsy was performed and histological diagnosis of intravascular large B-cell lymphoma (IVLBCL) was made.
  • FDG-PET/CT may be a useful tool for the early diagnosis of IVLBCL.
  • [MeSH-major] Fever of Unknown Origin / etiology. Lymphoma, Large B-Cell, Diffuse / complications. Lymphoma, Large B-Cell, Diffuse / diagnosis. Positron-Emission Tomography. Renal Insufficiency / etiology. Tomography, X-Ray Computed. Vascular Neoplasms / complications. Vascular Neoplasms / diagnosis

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  • (PMID = 19571511.001).
  • [ISSN] 0485-1439
  • [Journal-full-title] [Rinshō ketsueki] The Japanese journal of clinical hematology
  • [ISO-abbreviation] Rinsho Ketsueki
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18; 4F4X42SYQ6 / Rituximab; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; 9PHQ9Y1OLM / Prednisolone; D58G680W0G / pirarubicin; RSA8KO39WH / Vindesine
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39. Tsujimura A, Miyamura K, Kuwatsuka Y, Inamoto Y, Tokunaga M, Oba T, Terakura S, Suzuki R, Ito M, Murase T, Kodera Y: [Successful salvage therapy with cladribine and rituximab for a patient with a relapsed Asian variant of intravascular large B-cell lymphoma]. Rinsho Ketsueki; 2006 Oct;47(10):1387-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Successful salvage therapy with cladribine and rituximab for a patient with a relapsed Asian variant of intravascular large B-cell lymphoma].
  • The Asian variant of intravascular large B-cell lymphoma (AIVL) is a rare aggressive lymphoma characterized by various clinical symptoms, hemophagocytic syndrome and predominant growth within vessels.
  • A half year later, he presented with high fever, sweat, dementia and hepatosplenomegaly without lymphadenopathy.
  • A bone marrow biopsy showed prominent hemophagocytosis and immunological staining disclosed an augmented intrasinusal pattern of atypical large lymphocytes characteristic of the CD20+ and CD5+ phenotypes.
  • No serious adverse events were observed with the exception of grade 4 neutropenia and grade 3 thrombocytopenia.
  • CND-R therapy, which is effective for indolent lymphoma, may be one of the candidates in salvage therapy for relapsed AIVL.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Lymphoma, B-Cell / drug therapy. Salvage Therapy. Vascular Neoplasms / drug therapy

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  • (PMID = 17094579.001).
  • [ISSN] 0485-1439
  • [Journal-full-title] [Rinshō ketsueki] The Japanese journal of clinical hematology
  • [ISO-abbreviation] Rinsho Ketsueki
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 47M74X9YT5 / Cladribine; 4F4X42SYQ6 / Rituximab
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40. Shimada K, Kinoshita T, Naoe T, Nakamura S: Presentation and management of intravascular large B-cell lymphoma. Lancet Oncol; 2009 Sep;10(9):895-902
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Presentation and management of intravascular large B-cell lymphoma.
  • Intravascular large B-cell lymphoma (IVLBCL) is a rare disease entity of non-Hodgkin lymphoma according to the current WHO classification.
  • This rare form of B-cell lymphoma is characterised by selective growth of tumour cells in the lumina of small vessels of various organs.
  • Strange characteristics of IVLBCL, including the absence of marked lymphoadenopathy and the usually aggressive clinical behaviour, result in the delay of timely and accurate diagnosis and fatal complications.
  • The success achieved with the anti-CD20 chimeric monoclonal antibody, rituximab, represents an important milestone in the clinical practice of B-cell lymphoma.
  • This Review describes the cutting edge of research on IVLBCL, and discusses the unsolved issues from biological and clinical perspectives to provide a better understanding of this rare lymphoma.
  • [MeSH-major] Lymphoma, Large B-Cell, Diffuse / diagnosis. Lymphoma, Large B-Cell, Diffuse / therapy. Vascular Neoplasms / diagnosis. Vascular Neoplasms / therapy
  • [MeSH-minor] Antibodies, Monoclonal / administration & dosage. Antibodies, Monoclonal / adverse effects. Antibodies, Monoclonal, Murine-Derived. Antineoplastic Combined Chemotherapy Protocols / adverse effects. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Asia / epidemiology. Asian Continental Ancestry Group. Biomarkers, Tumor / blood. Europe / epidemiology. Humans. Lymphohistiocytosis, Hemophagocytic / etiology. Neoplasm Staging. Prognosis. Rituximab

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  • (PMID = 19717091.001).
  • [ISSN] 1474-5488
  • [Journal-full-title] The Lancet. Oncology
  • [ISO-abbreviation] Lancet Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Biomarkers, Tumor; 4F4X42SYQ6 / Rituximab
  • [Number-of-references] 73
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41. Shimada K, Murase T, Matsue K, Okamoto M, Ichikawa N, Tsukamoto N, Niitsu N, Miwa H, Asaoku H, Kosugi H, Kikuchi A, Matsumoto M, Saburi Y, Masaki Y, Yamamoto K, Yamaguchi M, Nakamura S, Naoe T, Kinoshita T, IVL Study Group in Japan: Central nervous system involvement in intravascular large B-cell lymphoma: a retrospective analysis of 109 patients. Cancer Sci; 2010 Jun;101(6):1480-6
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  • [Title] Central nervous system involvement in intravascular large B-cell lymphoma: a retrospective analysis of 109 patients.
  • Intravascular large B-cell lymphoma (IVLBCL) is a rare disease entity with a high incidence of central nervous system (CNS) involvement at diagnosis.
  • In 82 patients (75%) without CNS involvement at initial diagnosis, risk of CNS recurrence at 3 years was 25% with a median follow-up in survivors of 39 months (range, 2-158 months).
  • In 27 patients (25%) with CNS involvement at initial diagnosis, risk of CNS recurrence at 1 year was 25% with a median follow-up in survivors of 18 months (range, 10-77 months).
  • Duration from diagnosis to CNS recurrence tended to be short in patients with CNS involvement at diagnosis.
  • On multivariate analysis skin involvement at initial diagnosis was identified as a predictive factor for CNS recurrence in patients without CNS involvement at diagnosis (hazard ratio, 5.27; 95% confidence interval, 1.59-17.4; P = 0.007).
  • Survival rate after CNS recurrence at 2 years was 12% in patients without CNS involvement at diagnosis.
  • [MeSH-major] Central Nervous System Neoplasms / pathology. Lymphoma, Large B-Cell, Diffuse / pathology. Neoplasm Recurrence, Local / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antibodies, Monoclonal / therapeutic use. Antibodies, Monoclonal, Murine-Derived. Female. Hematopoietic Stem Cell Transplantation. Humans. Male. Middle Aged. Retrospective Studies. Rituximab

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  • (PMID = 20412122.001).
  • [ISSN] 1349-7006
  • [Journal-full-title] Cancer science
  • [ISO-abbreviation] Cancer Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 4F4X42SYQ6 / Rituximab
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42. Holmes NE, Gordon CL, Lightfoot N, Crowley P, Buchanan RR, Smith CL, Johnson PD: Intravascular large B cell lymphoma: an elusive cause of pyrexia of unknown origin diagnosed postmortem. Clin Infect Dis; 2010 Nov 1;51(9):e61-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intravascular large B cell lymphoma: an elusive cause of pyrexia of unknown origin diagnosed postmortem.
  • Intravascular large B cell lymphoma (IVLBCL) is a rare cause of pyrexia of unknown origin.
  • Because of its protean clinical manifestations, diagnosis is elusive and is often made postmortem.
  • We report here a case of IVLBCL that evaded diagnosis despite multiple investigations in vivo for pyrexia of unknown origin over a 5&#x2010;month period.
  • [MeSH-major] Fever of Unknown Origin / etiology. Lymphoma, B-Cell / complications. Lymphoma, B-Cell / diagnosis. Vascular Neoplasms / complications. Vascular Neoplasms / diagnosis

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  • (PMID = 20868278.001).
  • [ISSN] 1537-6591
  • [Journal-full-title] Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • [ISO-abbreviation] Clin. Infect. Dis.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD20
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43. Yasuda M, Akiyama N, Miyamoto S, Warabi M, Takahama Y, Kitamura M, Yakushiji F, Kinoshita H: Primary sellar lymphoma: intravascular large B-cell lymphoma diagnosed as a double cancer and improved with chemotherapy, and literature review of primary parasellar lymphoma. Pituitary; 2010;13(1):39-47
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary sellar lymphoma: intravascular large B-cell lymphoma diagnosed as a double cancer and improved with chemotherapy, and literature review of primary parasellar lymphoma.
  • Lymphoma is one of the causative factors of hypothalamus-pituitary dysfunction, and intravascular large B-cell lymphoma (IVLBCL) is a subtype of primary extranodal neoplasm.
  • Though we conducted systemic investigations including chest and abdomen enhanced computer tomography, transbronchial lung biopsy, and bone marrow biopsy, the diagnosis was not confirmed.
  • We reviewed 32 patients with primary parasellar lymphoma.
  • [MeSH-major] Lymphoma, B-Cell / diagnosis. Pituitary Neoplasms / diagnosis. Sella Turcica / pathology. Vascular Neoplasms / diagnosis
  • [MeSH-minor] Aged. Antineoplastic Agents / therapeutic use. Cranial Nerves / physiology. Cranial Nerves / physiopathology. Female. Humans. Neoplasms, Second Primary / diagnosis

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  • (PMID = 19707877.001).
  • [ISSN] 1573-7403
  • [Journal-full-title] Pituitary
  • [ISO-abbreviation] Pituitary
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 50
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44. Askarian F, Xu D: Adrenal enlargement and insufficiency: a common presentation of intravascular large B-cell lymphoma. Am J Hematol; 2006 Jun;81(6):411-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adrenal enlargement and insufficiency: a common presentation of intravascular large B-cell lymphoma.
  • Intravascular large B-cell lymphoma (IVLL) is a rare subtype of extranodal diffuse large B-cell lymphoma and is very difficult to diagnose in patients antemortem due to nonspecific presentation of the disease.
  • [MeSH-major] Adrenal Glands / ultrastructure. Adrenal Insufficiency / pathology. Lymphoma, B-Cell / pathology. Lymphoma, Large B-Cell, Diffuse / pathology

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  • (PMID = 16680734.001).
  • [ISSN] 0361-8609
  • [Journal-full-title] American journal of hematology
  • [ISO-abbreviation] Am. J. Hematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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45. Kitanaka A, Kubota Y, Imataki O, Ohnishi H, Fukumoto T, Kurokohchi K, Tanaka T: Intravascular large B-cell lymphoma with FDG accumulation in the lung lacking CT/(67)gallium scintigraphy abnormality. Hematol Oncol; 2009 Mar;27(1):46-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intravascular large B-cell lymphoma with FDG accumulation in the lung lacking CT/(67)gallium scintigraphy abnormality.
  • Intravascular large B-cell lymphoma (IVLBCL) is a rare lymphoma characterized by the presence of large tumour cells within the blood vessels.
  • It has been considered that IVLBCL is a highly malignant disease with poor prognosis.
  • However, it has been shown that a therapeutic effect resembling that of conventional B-cell lymphomas may be obtained with the application of systemic chemotherapy at the early stage of this disease.
  • Although involvement in the lung is often detected at autopsy, early diagnosis is quite difficult.
  • In this report, we present a case of IVLBCL with pulmonary involvement where 18-fluoro-deoxyglucose positron emission tomography (FDG-PET) was useful in the early diagnosis.
  • We propose that FDG-PET is a powerful tool for the early diagnosis of IVLBCL with pulmonary involvement, if the possibility of this disease presents in the patient with respiratory symptoms without abnormal findings by CT and (67)gallium scintigraphy.
  • [MeSH-major] Lung Neoplasms / radiography. Lymphoma, B-Cell / radiography. Lymphoma, B-Cell / radionuclide imaging
  • [MeSH-minor] Female. Fluorodeoxyglucose F18. Gallium Radioisotopes. Humans. Lung / metabolism. Lung / pathology. Middle Aged. Neoplasm Invasiveness. Prognosis. Splenomegaly / radiography. Splenomegaly / radionuclide imaging. Tomography, X-Ray Computed

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  • [Copyright] Copyright 2009 John Wiley & Sons, Ltd.
  • (PMID = 18819161.001).
  • [ISSN] 1099-1069
  • [Journal-full-title] Hematological oncology
  • [ISO-abbreviation] Hematol Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Gallium Radioisotopes; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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46. Nakamura Y, Nakamagoe K, Kawachi Y, Hosaka A, Mukai H, Chiba S, Otsuka F, Tamaoka A: Intravascular large B cell lymphoma with neurological symptoms diagnosed on the basis of a senile angioma-like eruption. BMJ Case Rep; 2009;2009
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intravascular large B cell lymphoma with neurological symptoms diagnosed on the basis of a senile angioma-like eruption.
  • Intravascular large B cell lymphoma (IVLBCL) presents various neurological symptoms, and the prognosis frequently deteriorates with a delay in diagnosis.
  • In addition, for the diagnosis of IVLBCL, invasive biopsies are generally performed in main organs, such as the brain.
  • We report a case of IVLBCL in which an early diagnosis was enabled by skin biopsy.
  • In cases in which IVLBCL could be suspected, an active search and biopsy of skin lesions, including an eruption of this type, are useful for early diagnosis and treatment.

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  • [Cites] Dermatology. 2004;209(2):132-4 [15316167.001]
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  • (PMID = 21686374.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3029526
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47. Le K, Lim A, Bullpitt P, Wood G: Intravascular B-cell lymphoma diagnosed by skin biopsy. Australas J Dermatol; 2005 Nov;46(4):261-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intravascular B-cell lymphoma diagnosed by skin biopsy.
  • He was eventually diagnosed with intravascular B- cell lymphoma on a random skin biopsy.
  • [MeSH-major] Lymphoma, B-Cell / complications. Lymphoma, B-Cell / pathology. Skin Diseases / etiology. Skin Diseases / pathology
  • [MeSH-minor] Abdomen. Amyloidosis / diagnosis. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cyclophosphamide / therapeutic use. Diagnosis, Differential. Doxorubicin / therapeutic use. Fever / etiology. Humans. Male. Middle Aged. Prednisolone / therapeutic use. Respiratory Insufficiency / etiology. Treatment Outcome. Vincristine / therapeutic use

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  • (PMID = 16197428.001).
  • [ISSN] 0004-8380
  • [Journal-full-title] The Australasian journal of dermatology
  • [ISO-abbreviation] Australas. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; 9PHQ9Y1OLM / Prednisolone; VAP-cyclo protocol
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48. Asada N, Odawara J, Kimura S, Aoki T, Yamakura M, Takeuchi M, Seki R, Tanaka A, Matsue K: Use of random skin biopsy for diagnosis of intravascular large B-cell lymphoma. Mayo Clin Proc; 2007 Dec;82(12):1525-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Use of random skin biopsy for diagnosis of intravascular large B-cell lymphoma.
  • Intravascular lymphoma (IVL) is a rare type of extranodal lymphoma with an aggressive clinical course characterized by proliferation of large lymphoma cells within the lumina of the small vessels.
  • Because of its varied clinical symptoms and the absence of lymphadenopathy, diagnosis of IVL is extremely difficult and requires histological confirmation.
  • Irrespective of the presence of skin lesions, almost all skin biopsy specimens showed obliteration of small vessels of subcutaneous fat tissues by lymphoma cells, allowing a prompt diagnosis of IVL.
  • Because diagnosis based on tissue other than skin is usually difficult in patients with suspected IVL, random skin biopsy should be considered even in patients with no evident skin lesions.
  • [MeSH-major] Biopsy / methods. Lymphoma, Large B-Cell, Diffuse / pathology. Skin / blood supply. Skin / pathology. Vascular Neoplasms / pathology

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  • (PMID = 18053461.001).
  • [ISSN] 0025-6196
  • [Journal-full-title] Mayo Clinic proceedings
  • [ISO-abbreviation] Mayo Clin. Proc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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49. Feldmann R, Schierl M, Sittenthaler M, Jahn R, Wogritsch C, Cerroni L, Steiner A, Breier F: Intravascular large B-cell lymphoma of the skin: typical clinical manifestations and a favourable response to rituximab-containing therapy. Dermatology; 2009;219(4):344-6
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  • [Title] Intravascular large B-cell lymphoma of the skin: typical clinical manifestations and a favourable response to rituximab-containing therapy.
  • Intravascular large B-cell lymphoma (IVBCL) is a rare malignant neoplasm characterized by the proliferation of large B cells within the blood vessels.
  • [MeSH-major] Antibodies, Monoclonal / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Lymphoma, Large B-Cell, Diffuse / drug therapy. Lymphoma, Large B-Cell, Diffuse / pathology. Skin Neoplasms / drug therapy. Skin Neoplasms / pathology. Vascular Neoplasms / drug therapy. Vascular Neoplasms / pathology

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  • [Copyright] Copyright 2009 S. Karger AG, Basel.
  • (PMID = 19590171.001).
  • [ISSN] 1421-9832
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 4F4X42SYQ6 / Rituximab; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; 9PHQ9Y1OLM / Prednisolone
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50. Xu X, Pang ZG, Liu WP, Zhang SF, Tang Y, Liao DY, Li GD: [Intravascular large B-cell lymphoma: report of two autopsy cases with literature review]. Zhonghua Bing Li Xue Za Zhi; 2008 Jun;37(6):377-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Intravascular large B-cell lymphoma: report of two autopsy cases with literature review].
  • OBJECTIVE: To study the clinicopathologic features of intravascular large B-cell lymphoma (IVLBCL).
  • The tumor cells were relatively monotonous and of medium to large in size with round vesicular nuclei and 1 to 3 small basophilic nucleoli.
  • Immunohistochemical study showed that the lymphoma cells expressed B-cell markers CD20 and CD79a, occasionally positive for CD5 and bcl-2 but negative for CD3, bcl-6, CD10, CD30, myeloperoxidase and cytokeratin.
  • Molecular study showed the presence of immunoglobulin heavy chain gene rearrangement in both cases, T-cell receptor-gamma gene rearrangement was not found.
  • CONCLUSIONS: IVLBCL may present as neurological disturbance and carries distinctive morphologic characteristics, immunophenotype and molecular findings.
  • [MeSH-major] Antigens, CD20 / analysis. Antigens, CD79 / analysis. Lymphoma, B-Cell / pathology. Lymphoma, Large B-Cell, Diffuse / pathology

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  • (PMID = 19031716.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD20; 0 / Antigens, CD79
  • [Number-of-references] 24
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51. Imai H, Shimada K, Shimada S, Abe M, Okamoto M, Kitamura K, Kinoshita T, Shiraishi T, Nakamura S: Comparative clinicopathological study of primary CNS diffuse large B-cell lymphoma and intravascular large B-cell lymphoma. Pathol Int; 2009 Jul;59(7):431-7
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  • [Title] Comparative clinicopathological study of primary CNS diffuse large B-cell lymphoma and intravascular large B-cell lymphoma.
  • Primary CNS diffuse large B-cell lymphoma (CNS DLBCL) is confined to the CNS, and constitutes a distinct entity.
  • All CD10-negative patients had non-germinal center B-cell type.
  • CNS DLBCL appeared to be homogenous as a group, which prompted the comparison with another distinct extranodal entity, intravascular large B-cell lymphoma (IVLBCL) in Japanese patients.
  • CNS DLBCL patients did not differ in age, sex, or immunophenotype, including CD5 positivity, from IVLBCL patients, but were significantly less likely to have poor prognostic parameters than IVLBCL patients: the international prognostic index score was low or low-intermediate in 86% of CNS DLBCL patients and high or high-intermediate in 98% of IVLBCL patients.
  • [MeSH-major] Central Nervous System Neoplasms / metabolism. Central Nervous System Neoplasms / mortality. Central Nervous System Neoplasms / pathology. Lymphoma, Large B-Cell, Diffuse / metabolism. Lymphoma, Large B-Cell, Diffuse / mortality. Lymphoma, Large B-Cell, Diffuse / pathology

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  • (PMID = 19563405.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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52. Ponzoni M, Ferreri AJ, Campo E, Facchetti F, Mazzucchelli L, Yoshino T, Murase T, Pileri SA, Doglioni C, Zucca E, Cavalli F, Nakamura S: Definition, diagnosis, and management of intravascular large B-cell lymphoma: proposals and perspectives from an international consensus meeting. J Clin Oncol; 2007 Jul 20;25(21):3168-73

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Definition, diagnosis, and management of intravascular large B-cell lymphoma: proposals and perspectives from an international consensus meeting.
  • Intravascular large B-cell lymphoma (IVLBCL) is a rare form of diffuse LBCL characterized by preferential intravascular growth of malignant lymphocytes, aggressive behavior, and an often fatal course.
  • Under the sponsorship of the International Extranodal Lymphoma Study Group, clinicians and pathologists with interest in IVLBCL, coming from Western and Eastern countries, joined to reach a consensus on defining features as well as to focus on the most urgent unresolved issues in IVLBCL.
  • Finally, a provisional practical diagnostic approach to hemophagocytosis-associated patients and a proposal for the most useful criteria in the settings of differential diagnosis are included.
  • [MeSH-major] Lymphoma, Large B-Cell, Diffuse / diagnosis. Lymphoma, Large B-Cell, Diffuse / therapy. Practice Guidelines as Topic. Vascular Neoplasms / diagnosis. Vascular Neoplasms / therapy
  • [MeSH-minor] Female. Humans. International Cooperation. Lymphoma, B-Cell / diagnosis. Lymphoma, B-Cell / therapy. Male. Sensitivity and Specificity

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  • (PMID = 17577023.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Consensus Development Conference; Journal Article
  • [Publication-country] United States
  • [Number-of-references] 34
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53. Kaku N, Seki M, Doi S, Hayashi T, Imanishi D, Imamura Y, Kurihara S, Miyazaki T, Izumikawa K, Kakeya H, Yamamoto Y, Yanagihara K, Tashiro T, Kohno S: A case of intravascular large B-cell lymphoma (IVLBCL) with no abnormal findings on chest computed tomography diagnosed by random transbronchial lung biopsy. Intern Med; 2010;49(24):2697-701
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of intravascular large B-cell lymphoma (IVLBCL) with no abnormal findings on chest computed tomography diagnosed by random transbronchial lung biopsy.
  • Intravascular large B-cell lymphoma (IVLBCL) was diagnosed, and her general status improved after chemotherapy.
  • [MeSH-major] Bronchoscopy. Lung Neoplasms / pathology. Lung Neoplasms / radiography. Lymphoma, Large B-Cell, Diffuse / pathology. Lymphoma, Large B-Cell, Diffuse / radiography. Tomography, X-Ray Computed

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  • (PMID = 21173545.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
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54. Niitsu N, Okamura D, Takahashi N, Tanae K, Hagiwara Y, Kayano H, Bessho M: Renal intravascular large B-cell lymphoma with early diagnosis by renal biopsy: a case report and review of the literature. Leuk Res; 2009 May;33(5):728-30
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  • [Title] Renal intravascular large B-cell lymphoma with early diagnosis by renal biopsy: a case report and review of the literature.
  • Intravascular large B-cell lymphoma (IVLBCL) is a rare entity of lymphoma.
  • Histopathological examination of the renal biopsy specimens showed dissemination of lymphoma cells throughout the glomerular capillary lumens.
  • We could perform early diagnosis by renal biopsy and were able to achieve long-term remission by rituximab combination chemotherapy.
  • [MeSH-major] Kidney Neoplasms / diagnosis. Lymphoma, B-Cell / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antibodies, Monoclonal / therapeutic use. Antibodies, Monoclonal, Murine-Derived. Antineoplastic Agents / therapeutic use. Biopsy. Early Diagnosis. Female. Humans. Immunohistochemistry. Male. Middle Aged. Rituximab

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  • (PMID = 19036442.001).
  • [ISSN] 1873-5835
  • [Journal-full-title] Leukemia research
  • [ISO-abbreviation] Leuk. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antineoplastic Agents; 4F4X42SYQ6 / Rituximab
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55. Ohno T, Sakamoto T, Mizumoto C, Miyoshi T, Ueda M, Takeoka T, Yamashita K, Hishita T, Hada S: Leukemic and meningeal relapse of CD5+ intravascular large B-cell lymphoma with down-modulation of CD20 after rituximab therapy. Int J Hematol; 2006 Jul;84(1):74-8
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  • [Title] Leukemic and meningeal relapse of CD5+ intravascular large B-cell lymphoma with down-modulation of CD20 after rituximab therapy.
  • Although CD20- relapses of B-cell lymphoma following rituximab therapy have increasingly been reported recently, coexistence of both the original and selected clones on relapse in a single patient have not been described.
  • We experienced such a case with rare CD5+ intravascular lymphomatosis (IVL).
  • The targeting of CD20 molecules on the tumor cell surface by rituximab may have provided a selective pressure on lymphoma cells.
  • The escape phenomenon of the lymphoma cells from rituximab was observed by simultaneously comparing the CD20 expression of cells in the peripheral blood and in a site of sanctuary from rituximab, the CSF.
  • [MeSH-major] Antigens, CD20. Antigens, CD5. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Lymphoma, B-Cell / prevention & control. Meningeal Neoplasms / prevention & control. Tumor Escape / drug effects

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  • (PMID = 16867907.001).
  • [ISSN] 0925-5710
  • [Journal-full-title] International journal of hematology
  • [ISO-abbreviation] Int. J. Hematol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antigens, CD20; 0 / Antigens, CD5; 4F4X42SYQ6 / Rituximab
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56. Hsieh MS, Yeh YC, Chou YH, Lin CW: Intravascular large B cell lymphoma in Taiwan: an Asian variant of non-germinal-center origin. J Formos Med Assoc; 2010 Mar;109(3):185-91

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intravascular large B cell lymphoma in Taiwan: an Asian variant of non-germinal-center origin.
  • BACKGROUND/PURPOSE: Intravascular large B cell lymphoma (IVLBCL) is a rare variant of diffuse large B cell lymphoma.

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  • [Copyright] 2010 Formosan Medical Association & Elsevier. Published by Elsevier B.V. All rights reserved.
  • (PMID = 20434026.001).
  • [ISSN] 0929-6646
  • [Journal-full-title] Journal of the Formosan Medical Association = Taiwan yi zhi
  • [ISO-abbreviation] J. Formos. Med. Assoc.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] Singapore
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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57. Mihaljevic B, Sternic N, Skender Gazibara M, Sretenovic A, Antic D, Terzic T, Kostic V: Intravascular large B-cell lymphoma of central nervous system - a report of two cases and literature review. Clin Neuropathol; 2010 Jul-Aug;29(4):233-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intravascular large B-cell lymphoma of central nervous system - a report of two cases and literature review.
  • Intravascular large B-cell lymphoma (IVL) is a rare form of diffuse large B cell lymphoma (DBCL) frequently presenting with skin and/or central nervous system (CNS) involvement.
  • Neuroimaging discloses CNS involvement only in half of patients with neurological symptoms because there are no pathognomonic neuroradiological findings for IVL; ischemic foci are the most common presentation pattern and therefore vasculitis is the most common differential diagnosis.
  • According to all mentioned data, diagnosis of CNS IVL requires a histopathological confirmation.
  • In younger patients with unfavorable features the high-dose chemotherapy with autologous stem cell transplantation should be used.
  • [MeSH-major] Brain Neoplasms / pathology. Lymphoma, Large B-Cell, Diffuse / pathology

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  • (PMID = 20569674.001).
  • [ISSN] 0722-5091
  • [Journal-full-title] Clinical neuropathology
  • [ISO-abbreviation] Clin. Neuropathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 18
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58. Yang T, Tian L, Li Q, Liu Y, Zhang Q, Ma Z, Zhang S, Zhou D: A case of intravascular B-cell lymphoma presenting as myelopathy and diagnosed post mortem. J Neurol Sci; 2008 Sep 15;272(1-2):196-8
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  • [Title] A case of intravascular B-cell lymphoma presenting as myelopathy and diagnosed post mortem.
  • The clinical presentation of intravascular lymphoma (IVL) is generally nonspecific and misleading and its course from onset to death is rapid.
  • Autopsy revealed intravascular large B-cell lymphoma.
  • [MeSH-major] Diagnosis. Lymphoma, B-Cell / diagnosis. Spinal Cord Diseases / diagnosis

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  • (PMID = 18620707.001).
  • [ISSN] 0022-510X
  • [Journal-full-title] Journal of the neurological sciences
  • [ISO-abbreviation] J. Neurol. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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59. Menéndez Calderón MJ, Seguí Riesco ME, Argüelles M, Nuño Mateo J: [Intravascular lymphomatosis. A report of three cases]. An Med Interna; 2005 Jan;22(1):31-4
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  • [Title] [Intravascular lymphomatosis. A report of three cases].
  • [Transliterated title] Linfomatosis intravascular. Descripción de tres casos.
  • Intravascular lymphomatosis (IVL) is a rare malignancy characterized by a proliferation of atypical lymphoid cells occluding small blood vessels (venules, capillaries and small arteries).
  • Nervous system and skin are the most common sites of involvement but all organs may be involved, although it is typified by the absence of malignant cells in lymphoid tissues.
  • Diagnosis can be made using biopsy of one of the involved organs.
  • In conclusion, we propose that IVL should be included in the differential diagnosis of acute confusional state, dementia or other unexplained neurological manifestations, fever of unknown origin, vasculitis, occult neoplasia or infections with signs of a systemic disease and marked elevation of serum lactate dehydrogenase (LDH).
  • [MeSH-major] Lymphoma / pathology. Vascular Neoplasms / pathology
  • [MeSH-minor] Aged. Autopsy. Diagnosis, Differential. Female. Humans. Male. Middle Aged

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  • (PMID = 15777121.001).
  • [ISSN] 0212-7199
  • [Journal-full-title] Anales de medicina interna (Madrid, Spain : 1984)
  • [ISO-abbreviation] An Med Interna
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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60. Kong YY, Dai B, Sheng WQ, Yang WT, Wang CF, Kong JC, Shi DR: Intravascular large B-cell lymphoma with cutaneous manifestations: a clinicopathologic, immunophenotypic and molecular study of three cases. J Cutan Pathol; 2009 Aug;36(8):865-70
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  • [Title] Intravascular large B-cell lymphoma with cutaneous manifestations: a clinicopathologic, immunophenotypic and molecular study of three cases.
  • BACKGROUND: Intravascular large B-cell lymphoma (IVLBCL) is an extremely rare type of malignant lymphoma characterized by exclusive or predominant growth of neoplastic cells within the lumen of blood vessels.
  • RESULTS: All three cases displayed the B-cell phenotype and showed monoclonality with immunoglobulin heavy chain gene rearrangement.
  • CONCLUSIONS: Skin manifestations and neurological findings, although to different degrees, are important clues to the diagnosis of IVLBCL.
  • As most IVLBCL are grouped into the post-germinal center B-cell subtype of diffuse large B-cell lymphoma, Bcl2 expression may be correlated with a worse prognosis in IVLBCL.
  • [MeSH-major] Gene Expression Regulation, Neoplastic. Gene Rearrangement, B-Lymphocyte. Immunoglobulin Heavy Chains / biosynthesis. Lymphoma, Large B-Cell, Diffuse. Proto-Oncogene Proteins c-bcl-2 / biosynthesis. Skin Neoplasms

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  • (PMID = 19040469.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Immunoglobulin Heavy Chains; 0 / Proto-Oncogene Proteins c-bcl-2
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61. Pekic S, Milicevic S, Colovic N, Colovic M, Popovic V: Intravascular large B-cell lymphoma as a cause of hypopituitarism: gradual and late reversal of hypopituitarism after long-term remission of lymphoma with immunochemotherapy. Endocrine; 2008 Aug-Dec;34(1-3):11-6
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  • [Title] Intravascular large B-cell lymphoma as a cause of hypopituitarism: gradual and late reversal of hypopituitarism after long-term remission of lymphoma with immunochemotherapy.
  • Intravascular large B-cell lymphoma (IVL) is a rare generally fatal disease characterized by massive proliferation of lymphoid cells within the small and medium blood vessels.
  • After complete hematological remission (6 months after initial diagnosis) reversal of cortisol and gonadotropin deficiency occurred.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Hypopituitarism / therapy. Immunotherapy. Lymphoma, Large B-Cell, Diffuse / therapy. Vascular Neoplasms / therapy

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  • (PMID = 18937075.001).
  • [ISSN] 1355-008X
  • [Journal-full-title] Endocrine
  • [ISO-abbreviation] Endocrine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 4F4X42SYQ6 / Rituximab; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CHOP protocol
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62. Jardin F, Callonnec F, Contentin N, Picquenot JM, Gueit I, Héron F, Bastard C, Tilly H: Intravascular large B-Cell lymphoma with bone marrow involvement and superior sagittal sinus thrombosis: report of a case successfully treated with a CHOP/rituximab combination regimen. Clin Lymphoma; 2005 Jun;6(1):46-9
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  • [Title] Intravascular large B-Cell lymphoma with bone marrow involvement and superior sagittal sinus thrombosis: report of a case successfully treated with a CHOP/rituximab combination regimen.
  • Intravascular large B-cell lymphoma (ILBCL) is a rare subtype of diffuse large B-cell lymphoma (as currently recognized by the World Health Organization classification) and is characterized by proliferation of mature B-cells within the lumina of small and medium vessels.
  • The diagnosis of ILBCL was established by a bone marrow biopsy that showed CD20+ tumor cells confined within the lumina of sinuses.
  • Magnetic resonance imaging of the brain revealed multiple high-signal areas in the periventricular white matter above the tentorium.
  • This observation highlights an unusual vascular aspect of ILBCL and the efficacy of the current standard treatment for this age group (CHOP/rituximab) in this particularly aggressive lymphoma subtype.
  • [MeSH-major] Antibodies, Monoclonal / therapeutic use. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bone Marrow / pathology. Lymphoma, B-Cell / drug therapy

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  • (PMID = 15989707.001).
  • [ISSN] 1526-9655
  • [Journal-full-title] Clinical lymphoma
  • [ISO-abbreviation] Clin Lymphoma
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antineoplastic Agents; 4F4X42SYQ6 / Rituximab; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CHOP protocol
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63. Jiang QL, Pytel P, Rowin J: Disseminated intravascular large-cell lymphoma with initial presentation mimicking Guillain-Barré syndrome. Muscle Nerve; 2010 Jul;42(1):133-6
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  • [Title] Disseminated intravascular large-cell lymphoma with initial presentation mimicking Guillain-Barré syndrome.
  • We report a patient with intravascular large B-cell lymphoma who initially presented with acute ascending weakness and sensory changes.
  • Autopsy revealed disseminated intravascular large-cell lymphoma.
  • Intravascular large-cell lymphoma should be considered in the differential diagnosis of a rapidly evolving neuropathy associated with other organ involvement.
  • [MeSH-major] Guillain-Barre Syndrome / pathology. Lymphoma, Large-Cell, Immunoblastic / pathology
  • [MeSH-minor] Anti-Inflammatory Agents / therapeutic use. Autopsy. Axons / pathology. Diagnosis, Differential. Electrodiagnosis. Fatal Outcome. Humans. Male. Middle Aged. Muscle Strength / physiology. Muscle Weakness / etiology. Muscle, Skeletal / pathology. Neural Conduction / physiology. Peripheral Nerves / physiopathology. Peripheral Nervous System Diseases / etiology. Peripheral Nervous System Diseases / pathology. Pupil / physiology. Respiratory Insufficiency / etiology. Steroids / therapeutic use


64. Kajiura D, Yamashita Y, Mori N: Diffuse large B-cell lymphoma initially manifesting in the bone marrow. Am J Clin Pathol; 2007 May;127(5):762-9
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  • [Title] Diffuse large B-cell lymphoma initially manifesting in the bone marrow.
  • We histologically and immunohistochemically studied 37 cases of diffuse large B-cell lymphoma (DLBCL) initially manifesting in the bone marrow (BM).
  • We also compared these cases with the Asian variant of intravascular large B-cell lymphoma (AIVL).
  • Histologically, the neoplastic cells of the BM mostly had large and round nuclei and formed clusters.
  • Immunohistochemically, all cases were positive for B-cell markers.
  • In several cases, the neoplastic cells infiltrated liver, spleen, kidneys, lungs, stomach, and adrenal glands with a mainly leukemic and infrequently intravascular pattern.
  • [MeSH-major] Bone Marrow Diseases / pathology. Lymphoma, B-Cell / pathology. Lymphoma, Large B-Cell, Diffuse / pathology

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  • (PMID = 17439835.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD5
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65. Serratrice J, Dussol B, Enã N, Benyamine A, Berland Y, Weiller PJ: Lymphoma-associated hemophagocytic syndrome: a rare cause of severe prerenal acute renal failure. Clin Nephrol; 2008 Jun;69(6):454-6

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  • [Title] Lymphoma-associated hemophagocytic syndrome: a rare cause of severe prerenal acute renal failure.
  • Post-mortem biopsies evidenced a highly aggressive B cell intravascular lymphoma without amyloidosis.
  • Physicians should be aware of the risk of anuric prerenal acute renal failure in the course of lymphoma-associated hemophagocytic syndrome.
  • [MeSH-major] Acute Kidney Injury / etiology. Lymphohistiocytosis, Hemophagocytic / complications. Lymphoma, B-Cell / complications

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  • (PMID = 18538123.001).
  • [ISSN] 0301-0430
  • [Journal-full-title] Clinical nephrology
  • [ISO-abbreviation] Clin. Nephrol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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66. Kotake T, Kosugi S, Takimoto T, Nakata S, Shiga J, Nagate Y, Nakagawa T, Take H, Katagiri S: Intravascular large B-cell lymphoma presenting pulmonary arterial hypertension as an initial manifestation. Intern Med; 2010;49(1):51-4
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  • [Title] Intravascular large B-cell lymphoma presenting pulmonary arterial hypertension as an initial manifestation.
  • We report a 39-year-old man with intravascular large B-cell lymphoma (IVLBCL) who had been treated as a case with pulmonary arterial hypertension (PAH) for one year.
  • After he became worse, diffuse pulmonary (18)F-fluorodeoxyglucose (FDG) uptake in positron emission tomography (PET) suggested the existence of IVLBCL in the lung showing normal CT images.
  • The diagnosis was confirmed with random transbronchial lung biopsy, and he was then successfully treated.
  • Since IVLBCL presenting PAH has been rare and is difficult to diagnose, early application of FDG-PET may provide early recognition of the disorder, leading to a better outcome.
  • [MeSH-major] Hypertension, Pulmonary / etiology. Lung Neoplasms / pathology. Lymphoma, Large B-Cell, Diffuse / complications. Lymphoma, Large B-Cell, Diffuse / pathology. Splenic Neoplasms / pathology


67. Morimoto K, Ogihara T, Shiomi T, Awaya N: Intravascular large B-cell lymphoma with preceding syndrome of inappropriate secretion of antidiuretic hormone. Intern Med; 2007;46(18):1569-72

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intravascular large B-cell lymphoma with preceding syndrome of inappropriate secretion of antidiuretic hormone.
  • Intravascular large B-cell lymphoma (IVL) is a rare subtype of B-cell lymphoma presenting with neurological and dermatological lesions in addition to generalized symptoms such as fever and malaise.
  • [MeSH-major] Inappropriate ADH Syndrome / pathology. Lymphoma, B-Cell / pathology. Lymphoma, Large B-Cell, Diffuse / pathology

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  • (PMID = 17878644.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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68. Kröber SM: [Intravascular lymphoma causing acute abdomen]. Pathologe; 2007 Feb;28(1):51-4
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  • [Title] [Intravascular lymphoma causing acute abdomen].
  • [Transliterated title] Intravaskuäres Lymphom als Ursache für akutes Abdomen.
  • The initial diagnosis was small bowel gangrene.
  • Pathology revealed small to large abdominal vessels obliterated by cells of intravascular B-cell-lymphoma (IVL).
  • The subtype of diffuse large B-cell lymphoma is a rare and aggressive malignancy, which in typical cases is characterized by cephalic or cutaneous manifestation.
  • Few cases showed involvement of large vessels which in combination to fibrin thrombi may lead to infarction of the organ involved.
  • [MeSH-major] Abdomen, Acute / etiology. Lymphoma, B-Cell / pathology. Lymphoma, Large B-Cell, Diffuse / pathology. Vascular Neoplasms / pathology

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  • (PMID = 17146642.001).
  • [ISSN] 0172-8113
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CHOP protocol
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69. Yin W, Li M, Gao Z, Huang F, Da J, Liu C: Intravascular large B-cell lymphoma with involvement of the abdominal subcutis: a case report and literature review. Int J Hematol; 2009 Apr;89(3):348-51

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intravascular large B-cell lymphoma with involvement of the abdominal subcutis: a case report and literature review.
  • Intravascular large B-cell lymphoma (IVLBCL) is a rare subtype of diffuse large B-cell lymphoma (DLBCL).
  • [MeSH-major] Lymphoma, Large B-Cell, Diffuse / pathology. Microcirculation. Neovascularization, Pathologic / pathology

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  • (PMID = 19255830.001).
  • [ISSN] 1865-3774
  • [Journal-full-title] International journal of hematology
  • [ISO-abbreviation] Int. J. Hematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 13
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70. Yamada N, Uchida R, Fuchida S, Okano A, Okamoto M, Ochiai N, Iwasa H, Shimazaki C: CD5+ Epstein-Barr virus-positive intravascular large B-cell lymphoma in the uterus co-existing with huge myoma. Am J Hematol; 2005 Mar;78(3):221-4
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  • [Title] CD5+ Epstein-Barr virus-positive intravascular large B-cell lymphoma in the uterus co-existing with huge myoma.
  • Histologically, she was diagnosed as having intravascular lymphoma co-existing with myoma uteri.
  • Lymphoma cells were large in size and were positive for CD5, CD20, CD45, CD79a, lambda light chain, and EBV but were negative for CD3 and cyclin D1.
  • No other organs except for the adjoining bilateral ovaries seemed to be affected by the lymphoma cells.
  • So far, this is the first case of CD5+ EBV+ intravascular large B-cell lymphoma (CD5+ EBV+ IVLBL) in the uterus of a patient who was incidentally diagnosed and successfully treated.
  • [MeSH-major] Antigens, CD5 / metabolism. Epstein-Barr Virus Infections / pathology. Leiomyoma / pathology. Lymphoma, B-Cell / pathology. Uterus / pathology. Vascular Neoplasms / pathology

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  • (PMID = 15726593.001).
  • [ISSN] 0361-8609
  • [Journal-full-title] American journal of hematology
  • [ISO-abbreviation] Am. J. Hematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD5
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71. Wong P, Moonie A, Dennett X, Anpalahan M: A case of intravascular lymphomatosis (IVL) presenting as polyneuropathy. Eur J Intern Med; 2006 Jan;17(1):59-60

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  • [Title] A case of intravascular lymphomatosis (IVL) presenting as polyneuropathy.
  • Intravascular lymphomatosis (IVL) is a rare, yet important, cause of a variety of unexplained neurological syndromes.
  • In this clinical context, the only clue to the diagnosis may be a significantly raised plasma lactate dehydrogenase (LDH) on a background of clinical features of a systemic illness.

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  • (PMID = 16378890.001).
  • [ISSN] 0953-6205
  • [Journal-full-title] European journal of internal medicine
  • [ISO-abbreviation] Eur. J. Intern. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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72. Morice WG, Rodriguez FJ, Hoyer JD, Kurtin PJ: Diffuse large B-cell lymphoma with distinctive patterns of splenic and bone marrow involvement: clinicopathologic features of two cases. Mod Pathol; 2005 Apr;18(4):495-502
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diffuse large B-cell lymphoma with distinctive patterns of splenic and bone marrow involvement: clinicopathologic features of two cases.
  • Two unusual cases of large B-cell lymphoma with predominant splenic and bone marrow (BM) involvement and similar clinical and histopathologic features are described.
  • Splenectomy revealed diffuse red pulp involvement by large B-cell lymphoma.
  • The perisplenic lymph nodes were also involved diffusely with effacement of normal nodal architecture, excluding a diagnosis of intravascular large B-cell lymphoma.
  • BM biopsies revealed striking erythroid hyperplasia without overt morphologic evidence of involvement by lymphoma.
  • Immunoperoxidase staining of the marrow biopsies with antibodies to CD20 and erythroid-associated antigens revealed involvement by large B-cell lymphoma morphologically resembling the early pronormoblasts.
  • In both cases there was prominent, but not exclusive, intravascular/intrasinusoidal lymphomatous marrow infiltration.
  • These cases represent an unusual variant of large B-cell lymphoma with distinctive patterns of splenic and BM involvement.
  • Furthermore, they underscore the difficulties in identifying intrasinusoidal marrow infiltration by lymphoma in H&E-stained biopsy slides and demonstrate that this pattern of marrow infiltration may be seen in cases of large B-cell lymphoma distinct from the intravascular variant.
  • [MeSH-major] Bone Marrow / pathology. Lymphoma, B-Cell / pathology. Lymphoma, Large B-Cell, Diffuse / pathology. Spleen / pathology

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  • (PMID = 15492760.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD
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73. Masaki Y, Dong L, Nakajima A, Iwao H, Miki M, Kurose N, Kinoshita E, Nojima T, Sawaki T, Kawanami T, Tanaka M, Shimoyama K, Kim C, Fukutoku M, Kawabata H, Fukushima T, Hirose Y, Takiguchi T, Konda S, Sugai S, Umehara H: Intravascular large B cell lymphoma: proposed of the strategy for early diagnosis and treatment of patients with rapid deteriorating condition. Int J Hematol; 2009 Jun;89(5):600-10
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  • [Title] Intravascular large B cell lymphoma: proposed of the strategy for early diagnosis and treatment of patients with rapid deteriorating condition.
  • We summarize our experience and propose methods for early diagnosis and treatment of intravascular large B cell lymphoma (IVL).
  • However, there have been marked improvement since the introduction of rituximab, and all patients responded to treatment and survived for more than 1 year following diagnosis of IVL.
  • Although accurate pathological diagnosis is quite important, time is a limiting factor for most of IVL patients.
  • In such cases, we can start chemotherapy based on early clinical diagnostic strategy with high sensitivity and obtain good clinical outcome.
  • [MeSH-major] Early Detection of Cancer. Lymphoma, B-Cell / diagnosis. Vascular Neoplasms / diagnosis

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  • (PMID = 19363707.001).
  • [ISSN] 1865-3774
  • [Journal-full-title] International journal of hematology
  • [ISO-abbreviation] Int. J. Hematol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 4F4X42SYQ6 / Rituximab
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74. Ferry JA, Sohani AR, Longtine JA, Schwartz RA, Harris NL: HHV8-positive, EBV-positive Hodgkin lymphoma-like large B-cell lymphoma and HHV8-positive intravascular large B-cell lymphoma. Mod Pathol; 2009 May;22(5):618-26
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  • [Title] HHV8-positive, EBV-positive Hodgkin lymphoma-like large B-cell lymphoma and HHV8-positive intravascular large B-cell lymphoma.
  • Human herpesvirus type 8 (HHV8), also known as Kaposi's sarcoma-associated herpesvirus, is a human gamma herpesvirus that underlies the pathogenesis of Kaposi's sarcoma, primary effusion lymphoma and multicentric Castleman's disease.
  • We recently encountered two cases of HHV8-positive large B-cell lymphoma with features not previously described.
  • The first patient was a 61-year-old immunocompetent man with an enlarged cervical lymph node containing scattered large, bizarre cells in a reactive background of lymphocytes, plasma cells and scattered regressed follicles resembling those of hyaline-vascular Castleman's disease.
  • The appearance suggested classical Hodgkin's lymphoma, but the large cells were negative for CD15, CD30, CD20 and CD3, and positive for MUM1/IRF4, EMA, HHV8, EBER and dim IgM lambda.
  • At autopsy an intravascular large B-cell lymphoma that was positive for MUM1/IRF4, HHV8 and IgM lambda, and negative for CD20 and EBER involved multiple organs, including lung, heart, kidney, liver and spleen.
  • [MeSH-major] Epstein-Barr Virus Infections / pathology. Herpesviridae Infections / pathology. Lymphoma, Large B-Cell, Diffuse / pathology. Lymphoma, Large B-Cell, Diffuse / virology

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  • (PMID = 19287457.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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75. Murase T, Yamaguchi M, Suzuki R, Okamoto M, Sato Y, Tamaru J, Kojima M, Miura I, Mori N, Yoshino T, Nakamura S: Intravascular large B-cell lymphoma (IVLBCL): a clinicopathologic study of 96 cases with special reference to the immunophenotypic heterogeneity of CD5. Blood; 2007 Jan 15;109(2):478-85

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intravascular large B-cell lymphoma (IVLBCL): a clinicopathologic study of 96 cases with special reference to the immunophenotypic heterogeneity of CD5.
  • Intravascular large B-cell lymphoma (IVLBCL) is pathologically distinct with a broad clinical spectrum and immunophenotypic heterogeneity.
  • The International Prognostic Index score was high or high-intermediate in 92%.
  • All 59 CD10- IVLBCL cases examined were nongerminal center B-cell type because they lacked the Bcl-6+MUM1- immunophenotype.
  • Compared with 97 cases of de novo CD5+CD10-diffuse LBCL, 31 cases of CD5+CD10-IVLBCL exhibited higher frequencies of poor prognostic parameters, except age.
  • [MeSH-major] Antigens, CD5 / analysis. Lymphoma, B-Cell / diagnosis. Lymphoma, B-Cell / immunology. Lymphoma, Large B-Cell, Diffuse / diagnosis. Lymphoma, Large B-Cell, Diffuse / immunology. Vascular Neoplasms / diagnosis. Vascular Neoplasms / immunology

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  • (PMID = 16985183.001).
  • [ISSN] 0006-4971
  • [Journal-full-title] Blood
  • [ISO-abbreviation] Blood
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD5
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76. Csomor J, Kaszás I, Kollár B, Pajor L, Egyházi Z, Fekete S, Egyed M, Timár B: Prolonged survival using anti-CD20 combined chemotherapy in primary prostatic intravascular large B-cell lymphoma. Pathol Oncol Res; 2008 Sep;14(3):281-4
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  • [Title] Prolonged survival using anti-CD20 combined chemotherapy in primary prostatic intravascular large B-cell lymphoma.
  • Here we report a case of a 73-year-old man with primary intravascular large B-cell lymphoma localized to the prostate.
  • The diagnosis of IVLBL was obtained incidentally from the prostatectomy specimen.
  • Eight months after the initial R-CHOP chemotherapy a relapse was detected in the left inguinal lymph node, where histologic examination revealed common diffuse large B-cell lymphoma with minimal intravascular component.
  • Successful treatment depends on early diagnosis of IVLBL, aggressive chemotherapy and the fact that IVLBL should be considered as a generalized disease in spite of negative staging results.
  • [MeSH-major] Antibodies, Monoclonal / therapeutic use. Antineoplastic Agents / therapeutic use. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Lymphoma, B-Cell / drug therapy. Prostatic Neoplasms / drug therapy

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  • (PMID = 18493873.001).
  • [ISSN] 1219-4956
  • [Journal-full-title] Pathology oncology research : POR
  • [ISO-abbreviation] Pathol. Oncol. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antineoplastic Agents; 3Z8479ZZ5X / Epirubicin; 4F4X42SYQ6 / Rituximab; 6PLQ3CP4P3 / Etoposide; UM20QQM95Y / Ifosfamide; IEV protocol
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77. Nixon BK, Kussick SJ, Carlon MJ, Rubin BP: Intravascular large B-cell lymphoma involving hemangiomas: an unusual presentation of a rare neoplasm. Mod Pathol; 2005 Aug;18(8):1121-6
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  • [Title] Intravascular large B-cell lymphoma involving hemangiomas: an unusual presentation of a rare neoplasm.
  • We report the clinicopathological features of two cases of intravascular large B-cell lymphoma involving cutaneous hemangiomas.
  • Biopsies and immunohistochemical evaluation of the hemangiomas revealed extensive involvement by intravascular large B-cell lymphoma.
  • One patient had a recurrence of disease 33 months after initial diagnosis, leading to an autologous stem cell transplant.
  • The other patient is without evidence of disease 27 months after initial diagnosis.
  • Although this is a rare neoplasm, it is important to consider intravascular large B-cell lymphoma in the differential diagnosis of vascular lesions containing intravascular neoplastic cells.
  • [MeSH-major] Hemangioma / pathology. Lymphoma, B-Cell / pathology. Lymphoma, Large B-Cell, Diffuse / pathology. Vascular Neoplasms / pathology
  • [MeSH-minor] Antigens, CD19 / analysis. Antigens, CD20 / analysis. Antigens, CD45 / analysis. Antigens, CD5 / analysis. DNA-Binding Proteins / analysis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Interferon Regulatory Factors. Middle Aged. Neoplasm Recurrence, Local. Proto-Oncogene Proteins / analysis. Proto-Oncogene Proteins c-bcl-6. Transcription Factors / analysis

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  • (PMID = 15803190.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD19; 0 / Antigens, CD20; 0 / Antigens, CD5; 0 / DNA-Binding Proteins; 0 / Interferon Regulatory Factors; 0 / Proto-Oncogene Proteins; 0 / Proto-Oncogene Proteins c-bcl-6; 0 / Transcription Factors; 0 / interferon regulatory factor-4; EC 3.1.3.48 / Antigens, CD45
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78. Harket A, Oukabli M, Al Bouzidi A, Zoubeir Y, Quamous O, Baba N, Doghmi K, Mikdame M, Rimani M, Sedrati O, Labraimi A: [Cutaneous blastomycosis revealing intravascular B-cell lymphoma: a case in Morocco]. Med Trop (Mars); 2007 Jun;67(3):278-80
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  • [Title] [Cutaneous blastomycosis revealing intravascular B-cell lymphoma: a case in Morocco].
  • [Transliterated title] Blastomycose cutanée révélant un lymphome B intravasculaire: une observation marocaine.
  • Needle liver biopsy revealed giant B-cell lymphomatous infiltration of the hepatic ducts.
  • The patient's condition worsened rapidly and he died five months after diagnosis despite four rounds of chemotherapy.
  • To our knowledge the association of blastomycosis and intravascular lymphoma has not been previously reported.
  • [MeSH-major] Blastomycosis / complications. Lymphoma, B-Cell / complications. Vascular Neoplasms / complications

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  • (PMID = 17784682.001).
  • [ISSN] 0025-682X
  • [Journal-full-title] Médecine tropicale : revue du Corps de santé colonial
  • [ISO-abbreviation] Med Trop (Mars)
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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79. Dauchy FA, Etienne G, Deminière C, Combe C, Merville P, Longy-Boursier M: [Lymphoma with initial renal involvement: four cases]. Rev Med Interne; 2006 Dec;27(12):909-15
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  • [Title] [Lymphoma with initial renal involvement: four cases].
  • [Transliterated title] Lymphomes à manifestations initiales rénales: à propos de quatre observations.
  • PURPOSE: To present a comprehensive description of the clinical features of patients with renal manifestations during lymphoma.
  • METHODS: Retrospective review of medical records from all patients diagnosed with lymphoma associated with kidney involvement in our hospital between 1996 to 2004.
  • RESULTS: Four patients presented a non-Hodgkin's lymphoma.
  • One patient showed intravascular large B-cell lymphoma, revealed by proteinuria.
  • Renal histology allowed diagnosis of lymphoma in 3 cases.
  • CONCLUSION: The diagnosis of lymphoma associated with renal involvement is rather difficult, and more specifically in case of intravascular large B-cell lymphoma, or even primary renal lymphoma.

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  • (PMID = 16952412.001).
  • [ISSN] 0248-8663
  • [Journal-full-title] La Revue de medecine interne
  • [ISO-abbreviation] Rev Med Interne
  • [Language] FRE
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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80. Horváth B, Demeter J, Eros N, Hársing J, Csomor J, Matolcsy A, Bottlik G, Gyori G, Marschalkó M, Kárpáti S: Intravascular large B-cell lymphoma: remission after rituximab-cyclophosphamide, doxorubicin, vincristine, and prednisolone chemotherapy. J Am Acad Dermatol; 2009 Nov;61(5):885-8
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  • [Title] Intravascular large B-cell lymphoma: remission after rituximab-cyclophosphamide, doxorubicin, vincristine, and prednisolone chemotherapy.
  • Intravascular lymphoma is an uncommon, very aggressive extranodal non-Hodgkin lymphoma that most frequently involves the skin and central nervous system.
  • Most cases are of B-cell origin; T-cell phenotype is extremely rare.
  • Malignant cells proliferate within the lumens of capillaries, arterioles, venules, and small arteries; vascular occlusion is responsible for the clinical signs and symptoms.
  • The prognosis of this high-grade B-cell lymphoma has improved since the introduction of the anti-CD20 monoclonal antibody, rituximab.
  • We describe a case of B-cell intravascular lymphoma successfully treated with rituximab and cyclophosphamide, doxorubicin, vincristine, and prednisolone.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Lymphoma, Large B-Cell, Diffuse / drug therapy. Skin / blood supply. Vascular Neoplasms / drug therapy

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  • (PMID = 19632742.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antineoplastic Agents; 0 / Antineoplastic Agents, Alkylating; 0 / Antineoplastic Agents, Hormonal; 0 / Antineoplastic Agents, Phytogenic; 4F4X42SYQ6 / Rituximab; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; 9PHQ9Y1OLM / Prednisolone
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81. Ott G, Rosenwald A: [Extranodal diffuse large B-cell lymphoma--an organotypic disease?]. Pathologe; 2007 Feb;28(1):29-35
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  • [Title] [Extranodal diffuse large B-cell lymphoma--an organotypic disease?].
  • [Transliterated title] Sind primär extranodale diffuse grosszellige B-Zell-Lymphome organotypische Erkrankungen?
  • Roughly 30-40% of diffuse large B-cell lymphomas (DLBCL) arise primarily in extranodal sites.
  • This is exemplified in the description of the DLBCL subtypes as defined by the World Health Organization classification (mediastinal or intravascular B-cell lymphoma; primary effusion lymphoma).
  • [MeSH-major] Lymphoma, B-Cell / pathology. Lymphoma, Large B-Cell, Diffuse / pathology

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  • (PMID = 17211671.001).
  • [ISSN] 0172-8113
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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82. Xie JL, Shi Y, Zhou XG, Jin Y, Zheng XD, Wei XJ: [Intralymphatic accumulation of lymphocytes mimicking intravascular lymphomatosis]. Zhonghua Bing Li Xue Za Zhi; 2010 Aug;39(8):518-21
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  • [Title] [Intralymphatic accumulation of lymphocytes mimicking intravascular lymphomatosis].
  • OBJECTIVE: To study the significance and differential diagnosis of intralymphatic accumulation of lymphocytes.
  • Immunohistochemical study revealed a T-cell phenotype of the intralymphatic lymphoid cells.
  • Although the lesion simulates intravascular lymphomatosis morphologically and shows a uniform T-cell phenotype, the lymphoid cells lack obvious cellular pleomorphism and mitotic activity.
  • The solitary nature of the lesion, when coupled with the indolent clinical behavior, is also helpful in the differential diagnosis.
  • [MeSH-minor] Adolescent. Adult. Antibodies, Monoclonal, Murine-Derived / metabolism. Antigens, CD3 / metabolism. Antigens, CD31 / metabolism. Child. Diagnosis, Differential. Female. Fibrosis. Follow-Up Studies. Humans. Lymphoma, B-Cell / metabolism. Lymphoma, B-Cell / pathology. Male. Middle Aged. Retrospective Studies. T-Lymphocytes / pathology. Young Adult

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  • (PMID = 21055029.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antigens, CD3; 0 / Antigens, CD31; 0 / monoclonal antibody D2-40
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83. Srivatsa S, Sharma J, Logani S: Intravascular lymphoma: an unusual diagnostic outcome of an incidentally detected adrenal mass. Endocr Pract; 2008 Oct;14(7):884-8
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  • [Title] Intravascular lymphoma: an unusual diagnostic outcome of an incidentally detected adrenal mass.
  • OBJECTIVE: To describe a rare diagnosis of intravascular lymphoma in a patient presenting with an incidentally discovered adrenal mass.
  • Since the lesion lacked high intensity and the biochemical testing results did not suggest a pheochromocytoma, it was deemed likely that the mass was a malignant lesion of the left adrenal gland.
  • Morphologic and immunohistochemical findings were consistent with a large B-cell lymphoma, which by virtue of its near exclusive distribution in vascular spaces, was consistent with the diagnosis of intravascular large B-cell lymphoma.
  • CONCLUSION: Intravascular large B-cell lymphoma should be included in the differential diagnosis of an incidentally detected adrenal mass even though the diagnosis is rare.
  • [MeSH-major] Adrenal Gland Diseases / diagnosis. Adrenal Gland Diseases / pathology. Lymphoma, Large B-Cell, Diffuse / diagnosis. Lymphoma, Large B-Cell, Diffuse / pathology

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  • (PMID = 18996818.001).
  • [ISSN] 1934-2403
  • [Journal-full-title] Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
  • [ISO-abbreviation] Endocr Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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84. Baraniskin A, Jähnert A, Ahle G, Theile A, Kretzschmar H, Schmiegel W, Schroers R: Intravascular large B-cell lymphoma presenting as dementia and hemolytic anemia. Onkologie; 2010;33(4):174-7
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  • [Title] Intravascular large B-cell lymphoma presenting as dementia and hemolytic anemia.
  • BACKGROUND: Intravascular lymphoma (IVL) is an uncommon disease characterized by atypical lymphoid cells growing inside the lumina of small vessels.
  • The diversity of clinical presentation due to possible involvement of multiple organs often complicates its diagnosis.
  • On post-mortem examination, intravascular large B-cell lymphoma with almost complete infiltration of the brain and lungs was diagnosed.
  • [MeSH-major] Anemia, Hemolytic / diagnosis. Anemia, Hemolytic / etiology. Dementia / diagnosis. Dementia / etiology. Lymphoma, Large B-Cell, Diffuse / complications. Lymphoma, Large B-Cell, Diffuse / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Male

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  • [Copyright] Copyright 2010 S. Karger AG, Basel.
  • (PMID = 20389143.001).
  • [ISSN] 1423-0240
  • [Journal-full-title] Onkologie
  • [ISO-abbreviation] Onkologie
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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85. Ruud KJ, Scheie D, Kerty E: [A 64-year old man with cognitive impairment and gait disturbance]. Tidsskr Nor Laegeforen; 2007 May 3;127(9):1210-1
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  • Intravascular lymphomatosis is a rare disease, characterized by occlusion of small arterioles and veins by malignant lymphoma cells.
  • Diagnosis is often delayed and made post mortem.
  • Intravascular lymphomatosis should be considered in patients with a combination of rapidly developing encephalopathy and focal neurological signs.
  • [MeSH-major] Brain Neoplasms / diagnosis. Cognition Disorders / diagnosis. Gait. Lymphoma, B-Cell / diagnosis. Lymphoma, Large B-Cell, Diffuse / diagnosis. Vascular Neoplasms / diagnosis
  • [MeSH-minor] Autopsy. Brain / blood supply. Brain / pathology. Diagnosis, Differential. Disease Progression. Fatal Outcome. Humans. Male. Middle Aged

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  • [CommentIn] Tidsskr Nor Laegeforen. 2007 May 3;127(9):1212 [17486713.001]
  • (PMID = 17486712.001).
  • [ISSN] 0807-7096
  • [Journal-full-title] Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række
  • [ISO-abbreviation] Tidsskr. Nor. Laegeforen.
  • [Language] nor
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Norway
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86. Mosunjac MB, Sundstrom JB, Mosunjac MI: Unusual presentation of anaplastic large cell lymphoma with clinical course mimicking fever of unknown origin and sepsis: autopsy study of five cases. Croat Med J; 2008 Oct;49(5):660-8
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  • [Title] Unusual presentation of anaplastic large cell lymphoma with clinical course mimicking fever of unknown origin and sepsis: autopsy study of five cases.
  • AIM: To describe a subset of cases with the unusual clinical and histomorphological presentation of anaplastic large cell lymphoma (ALCL) mimicking fever of unknown origin (FUO) and sepsis.
  • Of those, five cases that did not have a correct premortem diagnosis were further analyzed to elucidate the reasons for delayed and incorrect pre-mortem diagnosis.
  • The analyzed data included clinical presentation, duration of symptoms, duration of hospital stay, premortem presumed cause of death, white blood cell count, platelet count, anion gap and blood pH, liver enzymes (alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, alkaline phosphatase), lactate, coagulation tests (prothrombin time, partial thromboplastin time, fibrinogen, D-dimers), microbiology cultures, and radiology and surgical pathology reports.
  • Autopsy reports were reviewed for description of major gross findings, initial clinical diagnosis, and cause of death.
  • RESULTS: Five fatal and pre-mortem unrecognized ALCL cases were characterized by rapid decline, with histologic findings showing predominantly extranodal involvement, intravascular lymphomatosis, and hemophagocytosis.
  • The cases were also characterized by unusual clinical manifestations including a FUO, sepsis, and disseminated intravascular coagulation-like picture, lactic acidosis, hepatosplenomegaly, and absence of significant peripheral adenopathy.
  • Recognition of this clinical variant may facilitate early detection and potentially timely diagnosis and therapy.
  • [MeSH-major] Fever of Unknown Origin / etiology. Lymphoma, Large-Cell, Anaplastic / complications. Lymphoma, Large-Cell, Anaplastic / diagnosis. Sepsis / etiology
  • [MeSH-minor] Acidosis, Lactic / etiology. Adolescent. Adult. Aged. Autopsy. Child. Databases as Topic. Disseminated Intravascular Coagulation / etiology. Female. Hepatomegaly / etiology. Humans. Immunohistochemistry. Male. Middle Aged. Splenomegaly / etiology. Young Adult

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  • (PMID = 18925700.001).
  • [ISSN] 1332-8166
  • [Journal-full-title] Croatian medical journal
  • [ISO-abbreviation] Croat. Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
  • [Other-IDs] NLM/ PMC2582359
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87. Nakamichi N, Fukuhara S, Aozasa K, Morii E: NK-cell intravascular lymphomatosis--a mini-review. Eur J Haematol; 2008 Jul;81(1):1-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] NK-cell intravascular lymphomatosis--a mini-review.
  • The majority of cases of intravascular lymphomatosis (IVL) is derived from B cells.
  • The clinicopathological findings in six cases of NK-cell IVL (NK-IVL), including one new case, were summarised and compared with B-cell IVL (B-IVL) and T-cell IVL (T-IVL).
  • In summary, IVL of the B-, T- and NK-cell phenotypes is clinicopathologically distinct and shows similarities to their more common counterparts, i.e. diffuse large B-cell lymphoma, peripheral T-cell lymphoma, unspecified and extranodal NK/T-cell lymphoma, nasal type.
  • [MeSH-major] Killer Cells, Natural / pathology. Lymphoma, Non-Hodgkin / pathology. Vascular Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Antineoplastic Agents / therapeutic use. Female. Humans. Lymphoma, B-Cell. Lymphoma, T-Cell. Male. Middle Aged. Treatment Outcome

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  • (PMID = 18462254.001).
  • [ISSN] 1600-0609
  • [Journal-full-title] European journal of haematology
  • [ISO-abbreviation] Eur. J. Haematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 50
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88. Nakamichi I, Shimazu K, Ikeda J, Yamauchi A, Ishiko J, Mizuki M, Kanakura Y, Aozasa K: Intravascular lymphomatosis initially suspected from uterine cytology: a case report. Acta Cytol; 2009 Mar-Apr;53(2):198-200
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  • [Title] Intravascular lymphomatosis initially suspected from uterine cytology: a case report.
  • BACKGROUND: Because recognizable lesions are often absent, selection of biopsy sites for diagnosis of intravascular large B-cell lymphoma (IVL) is frequently problematic.
  • There were no genital symptoms, but uterine cytologic examination revealed large cells distributed in a noncohesive pattern.
  • These cells had a large, irregularly shaped nucleus in which several nucleoli were discernible and showed positive immunoreactivity for leukocyte common antigen.
  • Biopsy specimens from the brain lesion showed the proliferation of large lymphoid cells filling the lumina of small vessels and Virchow-Robin's space.
  • CONCLUSION: Uterine cytologic and/or histologic examinations could be the choice for diagnosis of IVL, even when genital symptoms are absent.
  • [MeSH-major] Blood Vessels / pathology. Brain / pathology. Lymphoma, Large B-Cell, Diffuse / pathology. Vascular Neoplasms / pathology

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  • (PMID = 19365976.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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89. Sawa N, Ubara Y, Katori H, Hoshino J, Suwabe T, Tagami T, Takemoto F, Miyakoshi S, Taniguchi S, Ohashi K, Takaichi K: Renal intravascular large B-cell lymphoma localized only within peritubular capillaries. Report of a case. Intern Med; 2007;46(10):657-62
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  • [Title] Renal intravascular large B-cell lymphoma localized only within peritubular capillaries. Report of a case.
  • We report a 35-year-old Japanese woman with intravascular large B-cell lymphoma diagnosed by percutaneous renal biopsy.
  • Percutaneous renal biopsy showed that an island-like atypical lymphoid cell accumulation was encircled with the peritubular capillary walls in many areas of the tubulo-interstitium, resulting in marked destruction of tubular structure.
  • Immunohistochemical analysis confirmed the diagnosis of intravascular large B-cell lymphoma.
  • Shortly after diagnosis, she was treated with rituximab, cyclophosphamide, hydroxydaunomycin, oncovin, and prednisolone, and her renal function and size improved.
  • Renal involvement by lymphoma has been classified into two categories: intraglomerular intravascular lymphoma and tubulointerstitial diffuse invasion type that is distinct from intravascular lymphoma.
  • For the latter cases with renal dysfunction and marked bilateral nephromegaly but without proteinuria, intravascular lymphoma within intra-peritublar capillaries should be considered as a possible diagnosis.
  • [MeSH-major] Capillaries / pathology. Kidney Glomerulus / pathology. Kidney Neoplasms / pathology. Lymphoma, B-Cell / pathology. Lymphoma, Large B-Cell, Diffuse / pathology

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  • (PMID = 17527039.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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90. Szuba A, Koba M, Rzeszutko M, Rzeszutko W, Dziegiel P, Loboda A, Dulak J, Andrzejak R: Cutaneous angiogenesis in patient with intravascular lymphoma (IVL): A case report. Dermatol Online J; 2010;16(8):2
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  • [Title] Cutaneous angiogenesis in patient with intravascular lymphoma (IVL): A case report.
  • We present a case of widespread cutaneous telangiectasias in a patient with a B-cell intravascular lymphoma most likely representing tumor-induced angiogenesis.
  • The patient presented with a rapid onset of large cutaneous telangiectasias and skin edema, followed by the development of multiorgan failure.
  • We describe difficulties with the ante-mortem diagnosis in the patient with predominant, clinically observed, skin lesions.
  • The final diagnosis of intravascular malignant lymphoma (IVL) was established post-mortem after morphological and immunohistochemical studies of the autopsy material.
  • [MeSH-major] Lymphoma, Large B-Cell, Diffuse / diagnosis. Neovascularization, Pathologic / diagnosis. Skin Neoplasms / blood supply. Skin Neoplasms / diagnosis. Telangiectasis / diagnosis. Vascular Neoplasms / diagnosis
  • [MeSH-minor] Aged. Antigens, CD20 / analysis. Antigens, CD79 / analysis. Fatal Outcome. Female. Humans. Multiple Organ Failure / diagnosis. Multiple Organ Failure / pathology

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  • (PMID = 20804679.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD20; 0 / Antigens, CD79
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91. Jiang L, Marlow LA, Cooper SJ, Roemeling CV, Menke DM, Copland JA, Tun HW: Selective central nervous system tropism of primary central nervous system lymphoma. Int J Clin Exp Pathol; 2010;3(8):763-7
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  • [Title] Selective central nervous system tropism of primary central nervous system lymphoma.
  • Primary Central nervous system lymphoma (PCNSL) is most frequently a diffuse large B cell lymphoma (DLBCL), which is confined to the Central nervous system (CNS).
  • We performed an experiment in which lymphoma cells from a PCNSL patient were implanted subcutaneously in an athymic mouse.
  • The lymphoma cells were shown to home to the CNS with histologic evaluations of the brain showing multiple large B cells in blood vessels consistent with intravascular large B cell lymphoma (IVL).
  • We did not find any evidence of lymphoma at the site of implantation or other locations.
  • [MeSH-major] Brain Neoplasms / pathology. Central Nervous System Neoplasms / pathology. Lymphoma, Large B-Cell, Diffuse / pathology
  • [MeSH-minor] Adult. Animals. Biomarkers, Tumor / metabolism. Brain / blood supply. Brain / pathology. Cell Movement. Fatal Outcome. Female. Humans. Lymphocytes / pathology. Mice. Mice, Nude. Neoplasm Invasiveness. Neoplasm Transplantation. Osteopontin / metabolism. Transplantation, Heterologous

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  • (PMID = 21151389.001).
  • [ISSN] 1936-2625
  • [Journal-full-title] International journal of clinical and experimental pathology
  • [ISO-abbreviation] Int J Clin Exp Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 106441-73-0 / Osteopontin
  • [Other-IDs] NLM/ PMC2993226
  • [Keywords] NOTNLM ; Lymphoma / central nervous system / tropism
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92. Rashid R, Johnson RJ, Morris S, Dickinson H, Czyz J, O'Connor SJ, Owen RG: Intravascular large B-cell lymphoma associated with a near-tetraploid karyotype, rearrangement of BCL6, and a t(11;14)(q13;q32). Cancer Genet Cytogenet; 2006 Dec;171(2):101-4
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  • [Title] Intravascular large B-cell lymphoma associated with a near-tetraploid karyotype, rearrangement of BCL6, and a t(11;14)(q13;q32).
  • Chromosome analysis of a patient with intravascular large B-cell lymphoma (IVL) revealed a complex, near-tetraploid karyotype with 83 chromosomes.
  • Abnormality of 3q was also evident.
  • [MeSH-major] Chromosomes, Human, Pair 11. Chromosomes, Human, Pair 14. DNA-Binding Proteins / genetics. Lymphoma, B-Cell / genetics. Lymphoma, Large B-Cell, Diffuse / genetics. Polyploidy. Translocation, Genetic. Vascular Neoplasms / genetics

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  • (PMID = 17116487.001).
  • [ISSN] 0165-4608
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / BCL6 protein, human; 0 / DNA-Binding Proteins
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93. Sips GJ, Amory CF, Delman BN, Kleinman GM, Lipsey LR, Tuhrim S: Intravascular lymphomatosis of the brain in a patient with myelodysplastic syndrome. Nat Rev Neurol; 2009 May;5(5):288-92
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  • [Title] Intravascular lymphomatosis of the brain in a patient with myelodysplastic syndrome.
  • BACKGROUND: A 77-year-old retired research pharmacologist with a long-standing history of anemia and a recent pathologically confirmed diagnosis of myelodysplastic syndrome was referred to a stroke unit for evaluation of slowly progressive cognitive deterioration, confusion and paroxysmal stroke-like episodes.
  • DIAGNOSIS: Intravascular lymphomatosis of the brain.
  • [MeSH-major] Brain Neoplasms / complications. Lymphoma, B-Cell / complications. Myelodysplastic Syndromes / complications


94. Szots M, Bors L, Kálmán E, Szapáry L, Illés Z: [Intravascular lymphomatosis: diagnostic problems of a rare disease]. Orv Hetil; 2007 Apr 22;148(16):749-52
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  • [Title] [Intravascular lymphomatosis: diagnostic problems of a rare disease].
  • [Transliterated title] Intravascularis lymphomatosis: egy ritka kórkép diagnosztikai nehézségei.
  • Intravascular lymphomatosis is a rare systemic disease characterized by proliferation of malignant B or rarely T lymphocytes.
  • Postmortem examination revealed intravascular proliferation of atypical mononuclear cells in the lumens of small vessels in all organs.
  • The authors conclude that diagnosis requires a high index of suspicion and pathological examination of the affected organs, but is rarely made ante mortem.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Brain Neoplasms / diagnosis. Lymphoma, Non-Hodgkin / diagnosis. Meningeal Neoplasms / diagnosis. Vascular Neoplasms / diagnosis
  • [MeSH-minor] Adrenal Glands / blood supply. B-Lymphocytes / pathology. Biopsy. Confusion / etiology. Diagnosis, Differential. Disease Progression. Fatal Outcome. Female. Humans. Middle Aged. Rare Diseases / diagnosis

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  • (PMID = 17437952.001).
  • [ISSN] 0030-6002
  • [Journal-full-title] Orvosi hetilap
  • [ISO-abbreviation] Orv Hetil
  • [Language] hun
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Hungary
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95. Ohkubo H, Yoshida T, Ohta K, Takaku T, Katagiri T, Paku J, Kasuga I, Minemura K, Gotoh A, Serizawa H, Mukai K, Ohyashiki K: [A case of pulmonary intravascular lymphoma treated with CHOP chemotherapy plus rituximab]. Gan To Kagaku Ryoho; 2005 Apr;32(4):553-6
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  • [Title] [A case of pulmonary intravascular lymphoma treated with CHOP chemotherapy plus rituximab].
  • We report a case of pulmonary intravascular lymphoma of large B cell type in a 72-year-old woman.
  • Chest X-ray revealed ground glass shadow in both lung fields, and the high-resolution CT disclosed centrilobular distribution of ground glass opacities.
  • Transbronchial lung biopsy demonstrated large lymphoid cells in the capillaries of alveolar septa.
  • As with diffuse large B cell lymphoma, CHOP chemotherapy plus rituximab may prove useful as a standard regimen for pulmonary intravascular lymphoma.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Lung / blood supply. Lymphoma, B-Cell / drug therapy. Lymphoma, Large B-Cell, Diffuse / drug therapy. Vascular Neoplasms / drug therapy

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  • (PMID = 15853227.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 4F4X42SYQ6 / Rituximab; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; 9PHQ9Y1OLM / Prednisolone; VAP-cyclo protocol
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96. Feng RE, Liu HR, Zhou WX, Shi JH, Tian XL, Wang HL, Ren XY, Ling Q, Cui QC: [Intravascular lymphomatosis presenting in the lung]. Zhonghua Jie He He Hu Xi Za Zhi; 2009 Jan;32(1):12-6
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  • [Title] [Intravascular lymphomatosis presenting in the lung].
  • OBJECTIVE: To investigate the clinical, radiographic and pathological characteristics of intravascular lymphomatosis primarily manifested in the lung, without skin and central nervous system involvements.
  • METHODS: A case of T cell intravascular lymphomatosis presenting with fever and multiple pulmonary shadows on chest radiograph was described and 14 similar cases reported in the English literature were reviewed.
  • RESULTS: We described a case of T cell intravascular lymphomatosis, who was a 36 year old man, complained of fever and multiple pulmonary shadows on chest radiograph and admitted to Peking Union Medical College Hospital in march, 2008.
  • Open lung biopsy showed features characteristic of intravascular lymphomatosis.
  • He received CHOP chemotherapy, but died 20 days after diagnosis.
  • Most cases of intravascular lymphomatosis primarily manifested in the lung occurred in older patients, ranging from 36 to 79 years of age (mean 59 years), with a male predominance (M : F = 11 : 4).
  • Eight cases had high serum lactate dehydrogenase levels.
  • Immunophenotypically, 10 cases were B cell lineage, 3 cases were T cell lineage.
  • Six cases of B cell intravascular lymphomatosis were followed, of whom 4 and were alive, and 2 died of respiratory failure.
  • Three cases of T cell intravascular lymphomatosis showed poor prognosis, both of whom died of respiratory failure.
  • CONCLUSIONS: Intravascular lymphomatosis primarily manifested in the lung is a rare malignant disease.
  • [MeSH-major] Lung / pathology. Lung Neoplasms / secretion. Lymphoma, Non-Hodgkin / pathology. Vascular Neoplasms / pathology

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  • (PMID = 19484955.001).
  • [ISSN] 1001-0939
  • [Journal-full-title] Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases
  • [ISO-abbreviation] Zhonghua Jie He He Hu Xi Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] China
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97. Bouzani M, Karmiris T, Rontogianni D, Delimpassi S, Apostolidis J, Mpakiri M, Nikiforakis E: Disseminated intravascular B-cell lymphoma: clinicopathological features and outcome of three cases treated with anthracycline-based immunochemotherapy. Oncologist; 2006 Sep;11(8):923-8
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  • [Title] Disseminated intravascular B-cell lymphoma: clinicopathological features and outcome of three cases treated with anthracycline-based immunochemotherapy.
  • The purpose of this study was to evaluate the use of combination anthracycline-based immunochemotherapy in intravascular lymphoma (IVL).
  • This is an extremely rare, disseminated, and aggressive extranodal CD20(+) non-Hodgkin's lymphoma (NHL) with poor outcome following anthracycline-based chemotherapy.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Lymphoma, B-Cell / drug therapy. Lymphoma, B-Cell / pathology. Lymphoma, Large B-Cell, Diffuse / drug therapy. Lymphoma, Large B-Cell, Diffuse / pathology

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  • (PMID = 16951396.001).
  • [ISSN] 1083-7159
  • [Journal-full-title] The oncologist
  • [ISO-abbreviation] Oncologist
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 4F4X42SYQ6 / Rituximab; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; 9PHQ9Y1OLM / Prednisolone; VAP-cyclo protocol
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98. Kusaba T, Hatta T, Tanda S, Kameyama H, Tamagaki K, Okigaki M, Inaba T, Shimazaki C, Sasaki S: Histological analysis on adhesive molecules of renal intravascular large B cell lymphoma treated with CHOP chemotherapy and rituximab. Clin Nephrol; 2006 Mar;65(3):222-6
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  • [Title] Histological analysis on adhesive molecules of renal intravascular large B cell lymphoma treated with CHOP chemotherapy and rituximab.
  • Urinary examination revealed mild protein excretion (0.54 g/day) and microhematuria; renal biopsy revealed the focal proliferation of large mononuclear cells with mitosis in glomerular capillaries.
  • According to immunohistochemical analysis, the intravascular lymphomatous cells stained positively with anti-leukocyte common antigen (LCA: CD45) and CD20, indicating a B lymphocyte lineage.
  • In electron microscopy, the glomerular capillary was filled with lymphoma cells and epithelial foot process fusion was noted.
  • Immunohistochemical analysis on adhesive molecules revealed a lack of CD11a expression on lymphoma cells, but positive CD54 expression on endothelial cells.
  • On the basis of these findings, we diagnosed intravascular diffuse large B cell lymphoma localized in the kidney.
  • In histopathological analysis of the second biopsy, lymphoma cells disappeared, but focal segmental glomerulosclerosis and moderate interstitial fibrosis were noted.
  • These pathological analyses let us conclude that a lack of CD11a could be a candidate factor for prevention of the extravasation of lymphoma cells from blood vessels in our patient.
  • We also presumed that the intraglomerular endothelial damage occurred due to chemotherapy-associated cell injury.
  • [MeSH-major] Antibodies, Monoclonal / therapeutic use. Antineoplastic Agents / therapeutic use. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cell Adhesion Molecules / metabolism. Glomerular Mesangium / ultrastructure. Kidney Neoplasms / pathology. Lymphoma, B-Cell / pathology
  • [MeSH-minor] Antibodies, Monoclonal, Murine-Derived. Biopsy. Cyclophosphamide / therapeutic use. Diagnosis, Differential. Doxorubicin / therapeutic use. Humans. Immunohistochemistry. Male. Microscopy, Electron. Middle Aged. Prednisone / therapeutic use. Rituximab. Vincristine / therapeutic use

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  • (PMID = 16550755.001).
  • [ISSN] 0301-0430
  • [Journal-full-title] Clinical nephrology
  • [ISO-abbreviation] Clin. Nephrol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antineoplastic Agents; 0 / Cell Adhesion Molecules; 4F4X42SYQ6 / Rituximab; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CHOP protocol
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99. Aznar AO, Montero MA, Rovira R, Vidal FR: Intravascular large B-cell lymphoma presenting with neurological syndromes: clinicopathologic study. Clin Neuropathol; 2007 Jul-Aug;26(4):180-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intravascular large B-cell lymphoma presenting with neurological syndromes: clinicopathologic study.
  • Intravascular lymphoma or intravascular lymphomatosis (IVL) is an uncommon extranodal lymphoma, which gives rise to exclusively intravascular tumor growth.
  • All these factors explain the difficulties involved in diagnosing this entity and the fact that in most cases the diagnosis is established on autopsy study.
  • Immunohistochemical findings demonstrated large B-cell lymphoma.
  • [MeSH-major] Lymphoma, B-Cell / pathology. Lymphoma, Large B-Cell, Diffuse / pathology. Paraneoplastic Syndromes, Nervous System / pathology. Polyradiculopathy / pathology. Spinal Cord Compression / pathology. Vascular Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Fatal Outcome. Humans. Lumbosacral Region. Male. Middle Aged

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  • (PMID = 17702500.001).
  • [ISSN] 0722-5091
  • [Journal-full-title] Clinical neuropathology
  • [ISO-abbreviation] Clin. Neuropathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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100. Iwagami Y, Sumitani M, Imahashi Y, Kiyota H, Kawano Y, Takifuji N, Takeda K, Kashii T: [A case of intravascular lymphomatosis with no abnormal findings on chest computed tomography and with diffuse pulmonary uptake of 67Ga on scintigraphy]. Nihon Kokyuki Gakkai Zasshi; 2006 Dec;44(12):923-7
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  • [Title] [A case of intravascular lymphomatosis with no abnormal findings on chest computed tomography and with diffuse pulmonary uptake of 67Ga on scintigraphy].
  • A 45-year-old man was admitted to our hospital with high-grade fever uncontrolled by antipyretic drugs, and elevation of the serum LDH and sIL-2R levels, and decrease of diffusing capacity for carbon monoxide.
  • Chest computed tomography (CT) showed no abnormal findings but 67Ga scintigraphy revealed diffuse pulmonary uptake.
  • He was given a diagnosis of intravascular lymphomatosis (IVL) based on transbronchial lung biopsy (TBLB) and immunohistochemical analysis.
  • The prognosis of IVL is generally bad, because antemortem diagnosis is difficult.
  • [MeSH-major] Gallium Radioisotopes. Lung Neoplasms / radionuclide imaging. Lymphoma, B-Cell / radionuclide imaging. Lymphoma, Large B-Cell, Diffuse / radionuclide imaging. Vascular Neoplasms / radionuclide imaging

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  • (PMID = 17233388.001).
  • [ISSN] 1343-3490
  • [Journal-full-title] Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
  • [ISO-abbreviation] Nihon Kokyuki Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Gallium Radioisotopes; 5J49Q6B70F / Vincristine; 7U1EE4V452 / Carbon Monoxide; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CHOP protocol
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