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1. Yang T, Tian L, Li Q, Liu Y, Zhang Q, Ma Z, Zhang S, Zhou D: A case of intravascular B-cell lymphoma presenting as myelopathy and diagnosed post mortem. J Neurol Sci; 2008 Sep 15;272(1-2):196-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of intravascular B-cell lymphoma presenting as myelopathy and diagnosed post mortem.
  • The clinical presentation of intravascular lymphoma (IVL) is generally nonspecific and misleading and its course from onset to death is rapid.
  • Autopsy revealed intravascular large B-cell lymphoma.
  • [MeSH-major] Diagnosis. Lymphoma, B-Cell / diagnosis. Spinal Cord Diseases / diagnosis

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  • (PMID = 18620707.001).
  • [ISSN] 0022-510X
  • [Journal-full-title] Journal of the neurological sciences
  • [ISO-abbreviation] J. Neurol. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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2. [Picture in clinical hematology: NK/T-cell lymphoma showing intravascular lymphomatosis]. Rinsho Ketsueki; 2007 Jul;48(7):539-40
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  • [Title] [Picture in clinical hematology: NK/T-cell lymphoma showing intravascular lymphomatosis].
  • [MeSH-major] Killer Cells, Natural / pathology. Lymphoma, T-Cell, Cutaneous / pathology. Skin Neoplasms / pathology

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  • (PMID = 17695301.001).
  • [ISSN] 0485-1439
  • [Journal-full-title] [Rinshō ketsueki] The Japanese journal of clinical hematology
  • [ISO-abbreviation] Rinsho Ketsueki
  • [Language] jpn
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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3. Nakamichi I, Shimazu K, Ikeda J, Yamauchi A, Ishiko J, Mizuki M, Kanakura Y, Aozasa K: Intravascular lymphomatosis initially suspected from uterine cytology: a case report. Acta Cytol; 2009 Mar-Apr;53(2):198-200
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  • [Title] Intravascular lymphomatosis initially suspected from uterine cytology: a case report.
  • BACKGROUND: Because recognizable lesions are often absent, selection of biopsy sites for diagnosis of intravascular large B-cell lymphoma (IVL) is frequently problematic.
  • There were no genital symptoms, but uterine cytologic examination revealed large cells distributed in a noncohesive pattern.
  • These cells had a large, irregularly shaped nucleus in which several nucleoli were discernible and showed positive immunoreactivity for leukocyte common antigen.
  • Biopsy specimens from the brain lesion showed the proliferation of large lymphoid cells filling the lumina of small vessels and Virchow-Robin's space.
  • CONCLUSION: Uterine cytologic and/or histologic examinations could be the choice for diagnosis of IVL, even when genital symptoms are absent.
  • [MeSH-major] Blood Vessels / pathology. Brain / pathology. Lymphoma, Large B-Cell, Diffuse / pathology. Vascular Neoplasms / pathology

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  • (PMID = 19365976.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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4. del Pozo J, Martínez W, Sacristán F, Rodríguez-Lozano J, Fonseca E: Reactive angioendotheliomatosis associated with myelodysplastic syndrome. Acta Derm Venereol; 2005;85(3):269-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Reactive angioendotheliomatosis associated with myelodysplastic syndrome.
  • [MeSH-major] Hemangioendothelioma / diagnosis. Myelodysplastic Syndromes / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged. Cold Temperature. Diagnosis, Differential. Ear. Humans. Male


5. Sukpanichnant S, Visuthisakchai S: Intravascular lymphomatosis: a study of 20 cases in Thailand and a review of the literature. Clin Lymphoma Myeloma; 2006 Jan;6(4):319-28
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  • [Title] Intravascular lymphomatosis: a study of 20 cases in Thailand and a review of the literature.
  • BACKGROUND: According to the World Health Organization classification (2001), intravascular large B-cell lymphoma (IVLBCL) is characterized by the presence of lymphoma cells only in the lumina of small vessels.
  • Intravascular large B-cell lymphoma and other intravascular lymphomatoses (IVLs), including IVL with B-cell phenotype and extravascular growth (B-IVL) and IVL with T-cell phenotype (T-IVL), were compared in a series of cases diagnosed at a single institution and in cases reported in the literature.
  • PATIENTS AND METHODS: Twenty cases of IVL diagnosed among 1826 consecutive cases of non-Hodgkin's lymphoma (NHL,1.1%) at Siriraj Hospital included 3 cases of IVLBCL, 14 cases of B-IVL, and 3 cases of T-IVL.
  • CONCLUSION: These results indicate that IVLBCL is not different from B-IVL or T-IVL in a biologic sense, and IVL seems to be better terminology than IVLBCL because it includes the T-cell phenotype that constitutes approximately 9% of cases.
  • Early diagnosis is very important because chemotherapy significantly prolongs survival.
  • [MeSH-major] Lymphoma, B-Cell / pathology. Vascular Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Disease-Free Survival. Female. Humans. Lymphoma, T-Cell / mortality. Lymphoma, T-Cell / pathology. Lymphoma, T-Cell / therapy. Male. Middle Aged. Prognosis. Retrospective Studies. Skin Neoplasms / mortality. Skin Neoplasms / pathology. Skin Neoplasms / secondary. Skin Neoplasms / therapy. Taiwan

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  • (PMID = 16507210.001).
  • [ISSN] 1557-9190
  • [Journal-full-title] Clinical lymphoma & myeloma
  • [ISO-abbreviation] Clin Lymphoma Myeloma
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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6. Mleczko A, Franke I, Scheinpflug K, Gollnick H, Leverkus M: Intravascular large B-cell lymphoma: successful therapy with bendamustine and rituximab. Acta Derm Venereol; 2009;89(4):425-7
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  • [Title] Intravascular large B-cell lymphoma: successful therapy with bendamustine and rituximab.
  • [MeSH-minor] Aged. Antibodies, Monoclonal, Murine-Derived. Bendamustine Hydrochloride. Blood Vessels / pathology. Drug Therapy, Combination. Female. Humans. Lymphocytes / pathology. Lymphoma, B-Cell. Remission Induction. Rituximab

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  • (PMID = 19688165.001).
  • [ISSN] 1651-2057
  • [Journal-full-title] Acta dermato-venereologica
  • [ISO-abbreviation] Acta Derm. Venereol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Sweden
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antineoplastic Agents; 0 / Nitrogen Mustard Compounds; 4F4X42SYQ6 / Rituximab; 981Y8SX18M / Bendamustine Hydrochloride
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7. Wakamatsu K, Komori M, Nagata N, Kumazoe H, Kajiki A, Kitahara Y: [Two cases of intravascular lymphomatosis diagnosed by transbronchial lung biopsy]. Nihon Kokyuki Gakkai Zasshi; 2009 Oct;47(10):875-80
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  • [Title] [Two cases of intravascular lymphomatosis diagnosed by transbronchial lung biopsy].
  • Patient 1 was a 54-year-old woman who was admitted with high-grade fever.
  • Chest computed tomography scans (CT) revealed diffuse ground-glass shadows in both lungs.
  • Transbronchial lung biopsy (TBLB) confirmed the diagnosis of intravascular lymphomatosis (IVL).
  • Patient 2 was a 46-year-old man who was also admitted with high-grade fever.
  • Chest CT images revealed diffuse, fine nodular densities in both lungs and several small nodules in the bilateral lower lobes.
  • TBLB specimens yielded a diagnosis of IVL.
  • Although antemortem diagnosis of IVL is frequently difficult, it is necessary to perform TBLB in those patients who show fever not responding to antibiotics, elevated levels of LDH and sIL-2R, and hypoxemia.
  • [MeSH-major] Biopsy / methods. Lung / pathology. Lymphoma, B-Cell / pathology. Vascular Neoplasms / pathology

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  • (PMID = 19882909.001).
  • [ISSN] 1343-3490
  • [Journal-full-title] Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
  • [ISO-abbreviation] Nihon Kokyuki Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 20
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8. Ishiguro T, Takayanagi N, Yanagisawa T, Kagiyama N, Saito H, Sugita Y, Kojima M: Pulmonary microvascular cytology can detect tumor cells of intravascular lymphoma. Intern Med; 2009;48(16):1425-8
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  • [Title] Pulmonary microvascular cytology can detect tumor cells of intravascular lymphoma.
  • Intravascular large B-cell lymphoma was suspected, and a pulmonary microvascular cytology specimen was obtained that contained numerous large lymphoma cells.
  • He was diagnosed as having diffuse large B-cell lymphoma.
  • Because lymphoma cells were found in the pulmonary microvasculature, intravascular lymphoma was also diagnosed.
  • Pulmonary microvascular cytology was helpful to detect lymphoma cells in the pulmonary microvasculature.
  • [MeSH-major] Lung / blood supply. Lung / pathology. Lymphoma, Large B-Cell, Diffuse / pathology. Microvessels / pathology. Vascular Neoplasms / pathology
  • [MeSH-minor] Aged. Anoxia / complications. Anoxia / diagnosis. Anoxia / pathology. Humans. Immunohistochemistry. Male. Thrombocytopenia / complications. Thrombocytopenia / diagnosis. Thrombocytopenia / pathology

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  • (PMID = 19687591.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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9. Ott G, Rosenwald A: [Extranodal diffuse large B-cell lymphoma--an organotypic disease?]. Pathologe; 2007 Feb;28(1):29-35
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  • [Title] [Extranodal diffuse large B-cell lymphoma--an organotypic disease?].
  • [Transliterated title] Sind primär extranodale diffuse grosszellige B-Zell-Lymphome organotypische Erkrankungen?
  • Roughly 30-40% of diffuse large B-cell lymphomas (DLBCL) arise primarily in extranodal sites.
  • This is exemplified in the description of the DLBCL subtypes as defined by the World Health Organization classification (mediastinal or intravascular B-cell lymphoma; primary effusion lymphoma).
  • [MeSH-major] Lymphoma, B-Cell / pathology. Lymphoma, Large B-Cell, Diffuse / pathology

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  • (PMID = 17211671.001).
  • [ISSN] 0172-8113
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
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10. Berger JR, Jones R, Wilson D: Intravascular lymphomatosis presenting with sudden hearing loss. J Neurol Sci; 2005 May 15;232(1-2):105-9
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  • [Title] Intravascular lymphomatosis presenting with sudden hearing loss.
  • Intravascular lymphoma (IVL) is a rare disorder characterized by the aggregation of malignant large cell lymphoma cells in small vessels.
  • Diagnosis is dependent on biopsy or postmortem demonstration of the intravascular tumor.
  • We report a patient in whom sudden hearing loss heralded IVL and propose that the hearing loss may have been the consequence of labyrinthine infarction consequent to the aggregation of malignant cells in the internal auditory artery.
  • [MeSH-major] Brain Neoplasms / complications. Hearing Loss, Sudden / etiology. Lymphoma, B-Cell / complications

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  • (PMID = 15850590.001).
  • [ISSN] 0022-510X
  • [Journal-full-title] Journal of the neurological sciences
  • [ISO-abbreviation] J. Neurol. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 9PHQ9Y1OLM / Prednisolone
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11. Mosunjac MB, Sundstrom JB, Mosunjac MI: Unusual presentation of anaplastic large cell lymphoma with clinical course mimicking fever of unknown origin and sepsis: autopsy study of five cases. Croat Med J; 2008 Oct;49(5):660-8
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  • [Title] Unusual presentation of anaplastic large cell lymphoma with clinical course mimicking fever of unknown origin and sepsis: autopsy study of five cases.
  • AIM: To describe a subset of cases with the unusual clinical and histomorphological presentation of anaplastic large cell lymphoma (ALCL) mimicking fever of unknown origin (FUO) and sepsis.
  • Of those, five cases that did not have a correct premortem diagnosis were further analyzed to elucidate the reasons for delayed and incorrect pre-mortem diagnosis.
  • The analyzed data included clinical presentation, duration of symptoms, duration of hospital stay, premortem presumed cause of death, white blood cell count, platelet count, anion gap and blood pH, liver enzymes (alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, alkaline phosphatase), lactate, coagulation tests (prothrombin time, partial thromboplastin time, fibrinogen, D-dimers), microbiology cultures, and radiology and surgical pathology reports.
  • Autopsy reports were reviewed for description of major gross findings, initial clinical diagnosis, and cause of death.
  • RESULTS: Five fatal and pre-mortem unrecognized ALCL cases were characterized by rapid decline, with histologic findings showing predominantly extranodal involvement, intravascular lymphomatosis, and hemophagocytosis.
  • The cases were also characterized by unusual clinical manifestations including a FUO, sepsis, and disseminated intravascular coagulation-like picture, lactic acidosis, hepatosplenomegaly, and absence of significant peripheral adenopathy.
  • Recognition of this clinical variant may facilitate early detection and potentially timely diagnosis and therapy.
  • [MeSH-major] Fever of Unknown Origin / etiology. Lymphoma, Large-Cell, Anaplastic / complications. Lymphoma, Large-Cell, Anaplastic / diagnosis. Sepsis / etiology
  • [MeSH-minor] Acidosis, Lactic / etiology. Adolescent. Adult. Aged. Autopsy. Child. Databases as Topic. Disseminated Intravascular Coagulation / etiology. Female. Hepatomegaly / etiology. Humans. Immunohistochemistry. Male. Middle Aged. Splenomegaly / etiology. Young Adult

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  • (PMID = 18925700.001).
  • [ISSN] 1332-8166
  • [Journal-full-title] Croatian medical journal
  • [ISO-abbreviation] Croat. Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
  • [Other-IDs] NLM/ PMC2582359
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12. Wu YN, Qi CH: [Intravascular large B-cell lymphoma of brain: report of a case]. Zhonghua Bing Li Xue Za Zhi; 2007 Mar;36(3):212-3
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  • [Title] [Intravascular large B-cell lymphoma of brain: report of a case].
  • [MeSH-major] Brain Neoplasms / pathology. Lymphoma, Large B-Cell, Diffuse / pathology. Vascular Neoplasms / pathology

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  • (PMID = 17535697.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD20; EC 3.1.3.48 / Antigens, CD45
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13. Higashiyama A, Hashino S, Onozawa M, Takahata M, Okada K, Kahata K, Taniguchi N, Nasuhara Y, Kubota K, Fujimoto N, Matsuno Y, Nishimura M, Asaka M: [Intravascular large B-cell lymphoma with massive pulmonary lesions]. Rinsho Ketsueki; 2010 May;51(5):353-6
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  • [Title] [Intravascular large B-cell lymphoma with massive pulmonary lesions].
  • The TBLB specimen was diagnosed as intravascular large B-cell lymphoma (IVLBCL).
  • In cases showing clinical findings such as hypoxia despite mild pulmonary radiographic changes, a definitive diagnosis should be made using methods such as TBLB with consideration given to the possibility of IVLBCL.
  • [MeSH-major] Lung Neoplasms / diagnosis. Lymphoma, Large B-Cell, Diffuse / diagnosis. Vascular Neoplasms / diagnosis. Vascular Neoplasms / pathology

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  • (PMID = 20534958.001).
  • [ISSN] 0485-1439
  • [Journal-full-title] [Rinshō ketsueki] The Japanese journal of clinical hematology
  • [ISO-abbreviation] Rinsho Ketsueki
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 4F4X42SYQ6 / Rituximab; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; 9PHQ9Y1OLM / Prednisolone; VAP-cyclo protocol
  • [Number-of-references] 5
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14. Chaukiyal P, Singh S, Woodlock T, Dolan JG, Bruner K: Intravascular large B-cell lymphoma with multisystem involvement. Leuk Lymphoma; 2006 Aug;47(8):1688-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intravascular large B-cell lymphoma with multisystem involvement.
  • [MeSH-major] Lymphoma, Large B-Cell, Diffuse / diagnosis. Vascular Neoplasms / diagnosis
  • [MeSH-minor] Antigens, CD45 / analysis. Fatal Outcome. Female. Humans. Lymphoma, B-Cell / diagnosis. Middle Aged. Multiple Organ Failure

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  • (PMID = 16966288.001).
  • [ISSN] 1042-8194
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] EC 3.1.3.48 / Antigens, CD45
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15. Ponzoni M, Ferreri AJ, Campo E, Facchetti F, Mazzucchelli L, Yoshino T, Murase T, Pileri SA, Doglioni C, Zucca E, Cavalli F, Nakamura S: Definition, diagnosis, and management of intravascular large B-cell lymphoma: proposals and perspectives from an international consensus meeting. J Clin Oncol; 2007 Jul 20;25(21):3168-73
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Definition, diagnosis, and management of intravascular large B-cell lymphoma: proposals and perspectives from an international consensus meeting.
  • Intravascular large B-cell lymphoma (IVLBCL) is a rare form of diffuse LBCL characterized by preferential intravascular growth of malignant lymphocytes, aggressive behavior, and an often fatal course.
  • Under the sponsorship of the International Extranodal Lymphoma Study Group, clinicians and pathologists with interest in IVLBCL, coming from Western and Eastern countries, joined to reach a consensus on defining features as well as to focus on the most urgent unresolved issues in IVLBCL.
  • Finally, a provisional practical diagnostic approach to hemophagocytosis-associated patients and a proposal for the most useful criteria in the settings of differential diagnosis are included.
  • [MeSH-major] Lymphoma, Large B-Cell, Diffuse / diagnosis. Lymphoma, Large B-Cell, Diffuse / therapy. Practice Guidelines as Topic. Vascular Neoplasms / diagnosis. Vascular Neoplasms / therapy
  • [MeSH-minor] Female. Humans. International Cooperation. Lymphoma, B-Cell / diagnosis. Lymphoma, B-Cell / therapy. Male. Sensitivity and Specificity

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  • (PMID = 17577023.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Consensus Development Conference; Journal Article
  • [Publication-country] United States
  • [Number-of-references] 34
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16. Kameoka Y, Takahashi N, Komatsuda A, Tagawa H, Hamai K, Hirokawa M, Wakui H, Ichinohasama R, Sawada K: Kidney-limited intravascular large B cell lymphoma: a distinct variant of IVLBCL? Int J Hematol; 2009 May;89(4):533-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Kidney-limited intravascular large B cell lymphoma: a distinct variant of IVLBCL?
  • Intravascular large B cell lymphoma (IVLBCL) is a rare type of non-Hodgkin lymphoma characterized by a disseminated intravascular proliferation of tumor cells in the lumina of small vessels.
  • Although the kidney is one of the target organs of IVLBCL, it is extremely rare that lymphoma cells are localized only in the kidney.
  • A renal biopsy showed large B cell neoplastic lymphocytes in the glomerular capillary lumina.
  • A follow-up renal biopsy showed the disappearance of intraglomerular lymphoma cells with restoration of glomerular architecture.
  • [MeSH-major] Kidney Neoplasms / blood supply. Kidney Neoplasms / pathology. Lymphoma, Large B-Cell, Diffuse / classification. Lymphoma, Large B-Cell, Diffuse / pathology

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  • (PMID = 19322627.001).
  • [ISSN] 1865-3774
  • [Journal-full-title] International journal of hematology
  • [ISO-abbreviation] Int. J. Hematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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17. Kato M, Ohshima K, Mizuno M, Kyogoku M, Hashikawa K, Tokura Y, Miyachi Y, Kabashima K: Analysis of CXCL9 and CXCR3 expression in a case of intravascular large B-cell lymphoma. J Am Acad Dermatol; 2009 Nov;61(5):888-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Analysis of CXCL9 and CXCR3 expression in a case of intravascular large B-cell lymphoma.
  • Intravascular large B-cell lymphoma is a rare disease with multiorgan involvement that also affects the skin.
  • We report a 68-year-old woman with bilateral leg edema and occasional high fever.
  • A biopsy specimen from a subcutaneous nodule showed that the blood vessels in the dermis and subcutaneous tissue were filled with irregularly shaped chromatin-rich large atypical lymphocytes positive for CD20 and bcl-2, consistent with the diagnosis of intravascular large B-cell lymphoma.
  • Although limited to a single case, our study could provide a possible new clue to the pathogenesis of intravascular large B-cell lymphoma by virtue of the characteristic expression of CXCL9-CXCR3.
  • [MeSH-major] Chemokine CXCL9 / metabolism. Lymphoma, Large B-Cell, Diffuse / metabolism. Lymphoma, Large B-Cell, Diffuse / pathology. Receptors, CXCR3 / metabolism. Vascular Neoplasms / metabolism. Vascular Neoplasms / pathology

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  • (PMID = 19766346.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CXCL9 protein, human; 0 / CXCR3 protein, human; 0 / Chemokine CXCL9; 0 / Receptors, CXCR3
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18. Serratrice J, Dussol B, Enã N, Benyamine A, Berland Y, Weiller PJ: Lymphoma-associated hemophagocytic syndrome: a rare cause of severe prerenal acute renal failure. Clin Nephrol; 2008 Jun;69(6):454-6
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  • [Title] Lymphoma-associated hemophagocytic syndrome: a rare cause of severe prerenal acute renal failure.
  • Post-mortem biopsies evidenced a highly aggressive B cell intravascular lymphoma without amyloidosis.
  • Physicians should be aware of the risk of anuric prerenal acute renal failure in the course of lymphoma-associated hemophagocytic syndrome.
  • [MeSH-major] Acute Kidney Injury / etiology. Lymphohistiocytosis, Hemophagocytic / complications. Lymphoma, B-Cell / complications

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  • (PMID = 18538123.001).
  • [ISSN] 0301-0430
  • [Journal-full-title] Clinical nephrology
  • [ISO-abbreviation] Clin. Nephrol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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19. Fukunaga M: Expression of D2-40 in lymphatic endothelium of normal tissues and in vascular tumours. Histopathology; 2005 Apr;46(4):396-402
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  • Ten of 10 cases of lymphangioma, nine of 10 Kaposi's sarcomas (KSs), one of five spindle cell haemangiomas, one of one reactive angioenodotheliomatosis, one of one vascular transformation of lymph node sinuses, three of three Dabska tumours, one of 10 epithelioid haemangioendotheliomas (HEs) and seven of 15 angiosarcomas were positive for D2-40.
  • Twenty-two non-spindle cell haemangiomas, one retiform HE and one Kaposiform HE, and five glomus tumours were negative for D2-40.
  • In comparison, CD31 was expressed in five of 10 lymphangiomas, nine of 10 KSs, 27 of 27 haemangiomas, three of three Dabska tumours, 10 of 10 epithelioid HEs, 15 of 15 angiosarcomas and one of one each of retiform HE, Kaposiform HE, reactive angioendotheliomatosis, and vascular transformation of node sinuses.
  • [MeSH-minor] Antibodies, Monoclonal, Murine-Derived. Antigens, CD31 / analysis. Antigens, Neoplasm / immunology. Humans. Immunohistochemistry. Lymphatic System

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  • (PMID = 15810951.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antigens, CD31; 0 / Antigens, Neoplasm; 0 / monoclonal antibody D2-40; 0 / oncofetal antigens
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20. Misago N, Yonekura N, Kuroiwa T, Yamanaka K, Narisawa Y: Simultaneous occurrence of reactive angioendotheliomatosis and leukocytoclastic vasculitis in a patient with periodontitis. Eur J Dermatol; 2008 Mar-Apr;18(2):193-4
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  • [Title] Simultaneous occurrence of reactive angioendotheliomatosis and leukocytoclastic vasculitis in a patient with periodontitis.
  • [MeSH-major] Hand Dermatoses / diagnosis. Periodontitis / diagnosis. Vasculitis / diagnosis
  • [MeSH-minor] Aged. Anti-Inflammatory Agents / administration & dosage. Anti-Inflammatory Agents / therapeutic use. Anti-Inflammatory Agents, Non-Steroidal / administration & dosage. Anti-Inflammatory Agents, Non-Steroidal / therapeutic use. Aspirin / administration & dosage. Aspirin / therapeutic use. Betamethasone / administration & dosage. Betamethasone / therapeutic use. Dental Care. Diagnosis, Differential. Drug Therapy, Combination. Female. Humans. Thigh / pathology

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  • (PMID = 18424386.001).
  • [ISSN] 1167-1122
  • [Journal-full-title] European journal of dermatology : EJD
  • [ISO-abbreviation] Eur J Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 0 / Anti-Inflammatory Agents, Non-Steroidal; 9842X06Q6M / Betamethasone; R16CO5Y76E / Aspirin
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21. Horváth B, Demeter J, Eros N, Hársing J, Csomor J, Matolcsy A, Bottlik G, Gyori G, Marschalkó M, Kárpáti S: Intravascular large B-cell lymphoma: remission after rituximab-cyclophosphamide, doxorubicin, vincristine, and prednisolone chemotherapy. J Am Acad Dermatol; 2009 Nov;61(5):885-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intravascular large B-cell lymphoma: remission after rituximab-cyclophosphamide, doxorubicin, vincristine, and prednisolone chemotherapy.
  • Intravascular lymphoma is an uncommon, very aggressive extranodal non-Hodgkin lymphoma that most frequently involves the skin and central nervous system.
  • Most cases are of B-cell origin; T-cell phenotype is extremely rare.
  • Malignant cells proliferate within the lumens of capillaries, arterioles, venules, and small arteries; vascular occlusion is responsible for the clinical signs and symptoms.
  • The prognosis of this high-grade B-cell lymphoma has improved since the introduction of the anti-CD20 monoclonal antibody, rituximab.
  • We describe a case of B-cell intravascular lymphoma successfully treated with rituximab and cyclophosphamide, doxorubicin, vincristine, and prednisolone.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Lymphoma, Large B-Cell, Diffuse / drug therapy. Skin / blood supply. Vascular Neoplasms / drug therapy

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  • (PMID = 19632742.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antineoplastic Agents; 0 / Antineoplastic Agents, Alkylating; 0 / Antineoplastic Agents, Hormonal; 0 / Antineoplastic Agents, Phytogenic; 4F4X42SYQ6 / Rituximab; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; 9PHQ9Y1OLM / Prednisolone
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22. Imai H, Shimada K, Shimada S, Abe M, Okamoto M, Kitamura K, Kinoshita T, Shiraishi T, Nakamura S: Comparative clinicopathological study of primary CNS diffuse large B-cell lymphoma and intravascular large B-cell lymphoma. Pathol Int; 2009 Jul;59(7):431-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparative clinicopathological study of primary CNS diffuse large B-cell lymphoma and intravascular large B-cell lymphoma.
  • Primary CNS diffuse large B-cell lymphoma (CNS DLBCL) is confined to the CNS, and constitutes a distinct entity.
  • All CD10-negative patients had non-germinal center B-cell type.
  • CNS DLBCL appeared to be homogenous as a group, which prompted the comparison with another distinct extranodal entity, intravascular large B-cell lymphoma (IVLBCL) in Japanese patients.
  • CNS DLBCL patients did not differ in age, sex, or immunophenotype, including CD5 positivity, from IVLBCL patients, but were significantly less likely to have poor prognostic parameters than IVLBCL patients: the international prognostic index score was low or low-intermediate in 86% of CNS DLBCL patients and high or high-intermediate in 98% of IVLBCL patients.
  • [MeSH-major] Central Nervous System Neoplasms / metabolism. Central Nervous System Neoplasms / mortality. Central Nervous System Neoplasms / pathology. Lymphoma, Large B-Cell, Diffuse / metabolism. Lymphoma, Large B-Cell, Diffuse / mortality. Lymphoma, Large B-Cell, Diffuse / pathology

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  • (PMID = 19563405.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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23. Imai T, Nishimura Y, Murata M, Saitou T, Yamamoto K, Mitsuhashi T, Shimada K, Satou K, Matsuyama T, Ozawa K: [Intravascular large B-cell lymphoma with left ventricular dysfunction]. Nihon Naika Gakkai Zasshi; 2008 Jul 10;97(7):1666-8
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  • [Title] [Intravascular large B-cell lymphoma with left ventricular dysfunction].
  • [MeSH-major] Lymphoma, Large B-Cell, Diffuse / complications. Ventricular Dysfunction, Left / complications

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  • (PMID = 18681155.001).
  • [ISSN] 0021-5384
  • [Journal-full-title] Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine
  • [ISO-abbreviation] Nippon Naika Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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24. Yamada N, Uchida R, Fuchida S, Okano A, Okamoto M, Ochiai N, Iwasa H, Shimazaki C: CD5+ Epstein-Barr virus-positive intravascular large B-cell lymphoma in the uterus co-existing with huge myoma. Am J Hematol; 2005 Mar;78(3):221-4
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  • [Title] CD5+ Epstein-Barr virus-positive intravascular large B-cell lymphoma in the uterus co-existing with huge myoma.
  • Histologically, she was diagnosed as having intravascular lymphoma co-existing with myoma uteri.
  • Lymphoma cells were large in size and were positive for CD5, CD20, CD45, CD79a, lambda light chain, and EBV but were negative for CD3 and cyclin D1.
  • No other organs except for the adjoining bilateral ovaries seemed to be affected by the lymphoma cells.
  • So far, this is the first case of CD5+ EBV+ intravascular large B-cell lymphoma (CD5+ EBV+ IVLBL) in the uterus of a patient who was incidentally diagnosed and successfully treated.
  • [MeSH-major] Antigens, CD5 / metabolism. Epstein-Barr Virus Infections / pathology. Leiomyoma / pathology. Lymphoma, B-Cell / pathology. Uterus / pathology. Vascular Neoplasms / pathology


25. Nakajima S, Ohshima K, Kyogoku M, Miyachi Y, Kabashima K: A case of intravascular large B-cell lymphoma with atypical clinical manifestations and analysis of CXCL12 and CXCR4 expression. Arch Dermatol; 2010 Jun;146(6):686-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of intravascular large B-cell lymphoma with atypical clinical manifestations and analysis of CXCL12 and CXCR4 expression.
  • [MeSH-major] Chemokine CXCL12 / biosynthesis. Lymphoma, Large B-Cell, Diffuse / diagnosis. Receptors, CXCR4 / biosynthesis. Skin / blood supply. Vascular Neoplasms / diagnosis
  • [MeSH-minor] Aged, 80 and over. Biomarkers, Tumor / metabolism. Biopsy. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Tomography, X-Ray Computed

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  • (PMID = 20566945.001).
  • [ISSN] 1538-3652
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Letter; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CXCR4 protein, human; 0 / Chemokine CXCL12; 0 / Receptors, CXCR4
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26. Yasuda H, Ando J, Matsumoto T, Ogura K, Ozaki Y, Aritaka N, Aoki Y, Sugita M, Nomura T, Sekii H, Yamaguchi N, Iguchi S, Yamamoto T, Komatsu N, Hirano T: Intravascular large B cell lymphoma with hepatic portal vein, splenic vein and mesenteric vein tumour embolism. Histopathology; 2010 Oct;57(4):648-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intravascular large B cell lymphoma with hepatic portal vein, splenic vein and mesenteric vein tumour embolism.
  • [MeSH-major] Lymphoma, Large B-Cell, Diffuse / pathology. Mesenteric Veins / pathology. Neoplastic Cells, Circulating / pathology. Portal Vein / pathology. Splenic Vein / pathology

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  • (PMID = 20955393.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
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27. Hsu YH, Tseng BY, Shyu WC, Yen PS: Intravascular lymphomatosis mimicking acute disseminated encephalomyelitis: a case report. Kaohsiung J Med Sci; 2005 Feb;21(2):93-7
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  • [Title] Intravascular lymphomatosis mimicking acute disseminated encephalomyelitis: a case report.
  • We describe the clinical, radiologic, and postmortem findings in a 49-year-old woman with intravascular lymphomatosis.
  • A diagnosis of disseminated intravascular large B-cell lymphomatosis was established based on findings from histopathology and immunohistochemistry studies on autopsy specimens of the brain and other visceral organs collected postmortem.
  • [MeSH-major] Encephalomyelitis, Acute Disseminated / pathology. Lymphoma, B-Cell / pathology

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  • (PMID = 15825696.001).
  • [ISSN] 1607-551X
  • [Journal-full-title] The Kaohsiung journal of medical sciences
  • [ISO-abbreviation] Kaohsiung J. Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
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28. Ferreri AJ, Dognini GP, Bairey O, Szomor A, Montalbán C, Horvath B, Demeter J, Uziel L, Soffietti R, Seymour JF, Ambrosetti A, Willemze R, Martelli M, Rossi G, Candoni A, De Renzo A, Doglioni C, Zucca E, Cavalli F, Ponzoni M, International Extranodal Lymphoma Study Group: The addition of rituximab to anthracycline-based chemotherapy significantly improves outcome in 'Western' patients with intravascular large B-cell lymphoma. Br J Haematol; 2008 Oct;143(2):253-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The addition of rituximab to anthracycline-based chemotherapy significantly improves outcome in 'Western' patients with intravascular large B-cell lymphoma.
  • Some case reports and a Japanese series suggest benefit from the use of rituximab in patients with intravascular large B-cell lymphoma (IVL).
  • [MeSH-major] Anthracyclines / therapeutic use. Antibodies, Monoclonal / therapeutic use. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Immunologic Factors / therapeutic use. Lymphoma, Large B-Cell, Diffuse / drug therapy. Vascular Neoplasms / drug therapy

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  • (PMID = 18699850.001).
  • [ISSN] 1365-2141
  • [Journal-full-title] British journal of haematology
  • [ISO-abbreviation] Br. J. Haematol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anthracyclines; 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Immunologic Factors; 4F4X42SYQ6 / Rituximab; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CHOP protocol
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29. Xu X, Pang ZG, Liu WP, Zhang SF, Tang Y, Liao DY, Li GD: [Intravascular large B-cell lymphoma: report of two autopsy cases with literature review]. Zhonghua Bing Li Xue Za Zhi; 2008 Jun;37(6):377-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Intravascular large B-cell lymphoma: report of two autopsy cases with literature review].
  • OBJECTIVE: To study the clinicopathologic features of intravascular large B-cell lymphoma (IVLBCL).
  • The tumor cells were relatively monotonous and of medium to large in size with round vesicular nuclei and 1 to 3 small basophilic nucleoli.
  • Immunohistochemical study showed that the lymphoma cells expressed B-cell markers CD20 and CD79a, occasionally positive for CD5 and bcl-2 but negative for CD3, bcl-6, CD10, CD30, myeloperoxidase and cytokeratin.
  • Molecular study showed the presence of immunoglobulin heavy chain gene rearrangement in both cases, T-cell receptor-gamma gene rearrangement was not found.
  • CONCLUSIONS: IVLBCL may present as neurological disturbance and carries distinctive morphologic characteristics, immunophenotype and molecular findings.
  • [MeSH-major] Antigens, CD20 / analysis. Antigens, CD79 / analysis. Lymphoma, B-Cell / pathology. Lymphoma, Large B-Cell, Diffuse / pathology

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  • (PMID = 19031716.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD20; 0 / Antigens, CD79
  • [Number-of-references] 24
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30. Holmes NE, Gordon CL, Lightfoot N, Crowley P, Buchanan RR, Smith CL, Johnson PD: Intravascular large B cell lymphoma: an elusive cause of pyrexia of unknown origin diagnosed postmortem. Clin Infect Dis; 2010 Nov 1;51(9):e61-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intravascular large B cell lymphoma: an elusive cause of pyrexia of unknown origin diagnosed postmortem.
  • Intravascular large B cell lymphoma (IVLBCL) is a rare cause of pyrexia of unknown origin.
  • Because of its protean clinical manifestations, diagnosis is elusive and is often made postmortem.
  • We report here a case of IVLBCL that evaded diagnosis despite multiple investigations in vivo for pyrexia of unknown origin over a 5‐month period.
  • [MeSH-major] Fever of Unknown Origin / etiology. Lymphoma, B-Cell / complications. Lymphoma, B-Cell / diagnosis. Vascular Neoplasms / complications. Vascular Neoplasms / diagnosis

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  • (PMID = 20868278.001).
  • [ISSN] 1537-6591
  • [Journal-full-title] Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • [ISO-abbreviation] Clin. Infect. Dis.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD20
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31. Shiraki K, Sugimoto K, Deguchi M, Ito N, Masuda C, Takei Y: Hepatic intravascular large B cell lymphoma. Intern Med; 2007;46(20):1761-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hepatic intravascular large B cell lymphoma.
  • [MeSH-major] Liver Neoplasms / diagnosis. Lymphoma, B-Cell / diagnosis. Lymphoma, Large B-Cell, Diffuse / diagnosis. Vascular Neoplasms / diagnosis

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  • (PMID = 17938536.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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32. Baraniskin A, Jähnert A, Ahle G, Theile A, Kretzschmar H, Schmiegel W, Schroers R: Intravascular large B-cell lymphoma presenting as dementia and hemolytic anemia. Onkologie; 2010;33(4):174-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intravascular large B-cell lymphoma presenting as dementia and hemolytic anemia.
  • BACKGROUND: Intravascular lymphoma (IVL) is an uncommon disease characterized by atypical lymphoid cells growing inside the lumina of small vessels.
  • The diversity of clinical presentation due to possible involvement of multiple organs often complicates its diagnosis.
  • On post-mortem examination, intravascular large B-cell lymphoma with almost complete infiltration of the brain and lungs was diagnosed.
  • [MeSH-major] Anemia, Hemolytic / diagnosis. Anemia, Hemolytic / etiology. Dementia / diagnosis. Dementia / etiology. Lymphoma, Large B-Cell, Diffuse / complications. Lymphoma, Large B-Cell, Diffuse / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Male

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  • [Copyright] Copyright 2010 S. Karger AG, Basel.
  • (PMID = 20389143.001).
  • [ISSN] 1423-0240
  • [Journal-full-title] Onkologie
  • [ISO-abbreviation] Onkologie
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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33. Quadri AM, Sylvester S, Verma S, Bareford D, Spychal RT, Jones EL, Ganesan R: Angiotropic large cell lymphoma presenting as intestinal obstruction. Ann Hematol; 2008 Jan;87(1):67-9
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  • [Title] Angiotropic large cell lymphoma presenting as intestinal obstruction.
  • [MeSH-major] Intestinal Obstruction / complications. Lymphoma, Large B-Cell, Diffuse / complications. Neovascularization, Pathologic

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  • (PMID = 17628802.001).
  • [ISSN] 1432-0584
  • [Journal-full-title] Annals of hematology
  • [ISO-abbreviation] Ann. Hematol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, CD79; 0 / Biomarkers
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34. Niitsu N, Okamura D, Takahashi N, Tanae K, Hagiwara Y, Kayano H, Bessho M: Renal intravascular large B-cell lymphoma with early diagnosis by renal biopsy: a case report and review of the literature. Leuk Res; 2009 May;33(5):728-30
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  • [Title] Renal intravascular large B-cell lymphoma with early diagnosis by renal biopsy: a case report and review of the literature.
  • Intravascular large B-cell lymphoma (IVLBCL) is a rare entity of lymphoma.
  • Histopathological examination of the renal biopsy specimens showed dissemination of lymphoma cells throughout the glomerular capillary lumens.
  • We could perform early diagnosis by renal biopsy and were able to achieve long-term remission by rituximab combination chemotherapy.
  • [MeSH-major] Kidney Neoplasms / diagnosis. Lymphoma, B-Cell / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antibodies, Monoclonal / therapeutic use. Antibodies, Monoclonal, Murine-Derived. Antineoplastic Agents / therapeutic use. Biopsy. Early Diagnosis. Female. Humans. Immunohistochemistry. Male. Middle Aged. Rituximab

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  • (PMID = 19036442.001).
  • [ISSN] 1873-5835
  • [Journal-full-title] Leukemia research
  • [ISO-abbreviation] Leuk. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antineoplastic Agents; 4F4X42SYQ6 / Rituximab
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35. Asada N, Odawara J, Kimura S, Aoki T, Yamakura M, Takeuchi M, Seki R, Tanaka A, Matsue K: Use of random skin biopsy for diagnosis of intravascular large B-cell lymphoma. Mayo Clin Proc; 2007 Dec;82(12):1525-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Use of random skin biopsy for diagnosis of intravascular large B-cell lymphoma.
  • Intravascular lymphoma (IVL) is a rare type of extranodal lymphoma with an aggressive clinical course characterized by proliferation of large lymphoma cells within the lumina of the small vessels.
  • Because of its varied clinical symptoms and the absence of lymphadenopathy, diagnosis of IVL is extremely difficult and requires histological confirmation.
  • Irrespective of the presence of skin lesions, almost all skin biopsy specimens showed obliteration of small vessels of subcutaneous fat tissues by lymphoma cells, allowing a prompt diagnosis of IVL.
  • Because diagnosis based on tissue other than skin is usually difficult in patients with suspected IVL, random skin biopsy should be considered even in patients with no evident skin lesions.
  • [MeSH-major] Biopsy / methods. Lymphoma, Large B-Cell, Diffuse / pathology. Skin / blood supply. Skin / pathology. Vascular Neoplasms / pathology

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  • (PMID = 18053461.001).
  • [ISSN] 0025-6196
  • [Journal-full-title] Mayo Clinic proceedings
  • [ISO-abbreviation] Mayo Clin. Proc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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36. Dauchy FA, Etienne G, Deminière C, Combe C, Merville P, Longy-Boursier M: [Lymphoma with initial renal involvement: four cases]. Rev Med Interne; 2006 Dec;27(12):909-15
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Lymphoma with initial renal involvement: four cases].
  • [Transliterated title] Lymphomes à manifestations initiales rénales: à propos de quatre observations.
  • PURPOSE: To present a comprehensive description of the clinical features of patients with renal manifestations during lymphoma.
  • METHODS: Retrospective review of medical records from all patients diagnosed with lymphoma associated with kidney involvement in our hospital between 1996 to 2004.
  • RESULTS: Four patients presented a non-Hodgkin's lymphoma.
  • One patient showed intravascular large B-cell lymphoma, revealed by proteinuria.
  • Renal histology allowed diagnosis of lymphoma in 3 cases.
  • CONCLUSION: The diagnosis of lymphoma associated with renal involvement is rather difficult, and more specifically in case of intravascular large B-cell lymphoma, or even primary renal lymphoma.

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  • (PMID = 16952412.001).
  • [ISSN] 0248-8663
  • [Journal-full-title] La Revue de medecine interne
  • [ISO-abbreviation] Rev Med Interne
  • [Language] FRE
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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37. Le K, Lim A, Bullpitt P, Wood G: Intravascular B-cell lymphoma diagnosed by skin biopsy. Australas J Dermatol; 2005 Nov;46(4):261-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intravascular B-cell lymphoma diagnosed by skin biopsy.
  • He was eventually diagnosed with intravascular B- cell lymphoma on a random skin biopsy.
  • [MeSH-major] Lymphoma, B-Cell / complications. Lymphoma, B-Cell / pathology. Skin Diseases / etiology. Skin Diseases / pathology
  • [MeSH-minor] Abdomen. Amyloidosis / diagnosis. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cyclophosphamide / therapeutic use. Diagnosis, Differential. Doxorubicin / therapeutic use. Fever / etiology. Humans. Male. Middle Aged. Prednisolone / therapeutic use. Respiratory Insufficiency / etiology. Treatment Outcome. Vincristine / therapeutic use

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  • (PMID = 16197428.001).
  • [ISSN] 0004-8380
  • [Journal-full-title] The Australasian journal of dermatology
  • [ISO-abbreviation] Australas. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; 9PHQ9Y1OLM / Prednisolone; VAP-cyclo protocol
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38. Harket A, Oukabli M, Al Bouzidi A, Zoubeir Y, Quamous O, Baba N, Doghmi K, Mikdame M, Rimani M, Sedrati O, Labraimi A: [Cutaneous blastomycosis revealing intravascular B-cell lymphoma: a case in Morocco]. Med Trop (Mars); 2007 Jun;67(3):278-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Cutaneous blastomycosis revealing intravascular B-cell lymphoma: a case in Morocco].
  • [Transliterated title] Blastomycose cutanée révélant un lymphome B intravasculaire: une observation marocaine.
  • Needle liver biopsy revealed giant B-cell lymphomatous infiltration of the hepatic ducts.
  • The patient's condition worsened rapidly and he died five months after diagnosis despite four rounds of chemotherapy.
  • To our knowledge the association of blastomycosis and intravascular lymphoma has not been previously reported.
  • [MeSH-major] Blastomycosis / complications. Lymphoma, B-Cell / complications. Vascular Neoplasms / complications

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  • (PMID = 17784682.001).
  • [ISSN] 0025-682X
  • [Journal-full-title] Médecine tropicale : revue du Corps de santé colonial
  • [ISO-abbreviation] Med Trop (Mars)
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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39. Kusaba T, Hatta T, Tanda S, Kameyama H, Tamagaki K, Okigaki M, Inaba T, Shimazaki C, Sasaki S: Histological analysis on adhesive molecules of renal intravascular large B cell lymphoma treated with CHOP chemotherapy and rituximab. Clin Nephrol; 2006 Mar;65(3):222-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Histological analysis on adhesive molecules of renal intravascular large B cell lymphoma treated with CHOP chemotherapy and rituximab.
  • Urinary examination revealed mild protein excretion (0.54 g/day) and microhematuria; renal biopsy revealed the focal proliferation of large mononuclear cells with mitosis in glomerular capillaries.
  • According to immunohistochemical analysis, the intravascular lymphomatous cells stained positively with anti-leukocyte common antigen (LCA: CD45) and CD20, indicating a B lymphocyte lineage.
  • In electron microscopy, the glomerular capillary was filled with lymphoma cells and epithelial foot process fusion was noted.
  • Immunohistochemical analysis on adhesive molecules revealed a lack of CD11a expression on lymphoma cells, but positive CD54 expression on endothelial cells.
  • On the basis of these findings, we diagnosed intravascular diffuse large B cell lymphoma localized in the kidney.
  • In histopathological analysis of the second biopsy, lymphoma cells disappeared, but focal segmental glomerulosclerosis and moderate interstitial fibrosis were noted.
  • These pathological analyses let us conclude that a lack of CD11a could be a candidate factor for prevention of the extravasation of lymphoma cells from blood vessels in our patient.
  • We also presumed that the intraglomerular endothelial damage occurred due to chemotherapy-associated cell injury.
  • [MeSH-major] Antibodies, Monoclonal / therapeutic use. Antineoplastic Agents / therapeutic use. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cell Adhesion Molecules / metabolism. Glomerular Mesangium / ultrastructure. Kidney Neoplasms / pathology. Lymphoma, B-Cell / pathology
  • [MeSH-minor] Antibodies, Monoclonal, Murine-Derived. Biopsy. Cyclophosphamide / therapeutic use. Diagnosis, Differential. Doxorubicin / therapeutic use. Humans. Immunohistochemistry. Male. Microscopy, Electron. Middle Aged. Prednisone / therapeutic use. Rituximab. Vincristine / therapeutic use

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  • (PMID = 16550755.001).
  • [ISSN] 0301-0430
  • [Journal-full-title] Clinical nephrology
  • [ISO-abbreviation] Clin. Nephrol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antineoplastic Agents; 0 / Cell Adhesion Molecules; 4F4X42SYQ6 / Rituximab; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CHOP protocol
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40. Shimada K, Kosugi H, Shimada S, Narimatsu H, Koyama Y, Suzuki N, Yuge M, Nishibori H, Iwata Y, Nakamura S, Naoe T, Kinoshita T: Evaluation of organ involvement in intravascular large B-cell lymphoma by 18F-fluorodeoxyglucose positron emission tomography. Int J Hematol; 2008 Sep;88(2):149-53
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Evaluation of organ involvement in intravascular large B-cell lymphoma by 18F-fluorodeoxyglucose positron emission tomography.
  • To evaluate the role of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) in intravascular large B-cell lymphoma (IVLBCL), we retrospectively analyzed four consecutive IVLBCL patients receiving FDG-PET before treatment between May 2006 and November 2007.
  • All patients received bone marrow biopsies and random skin biopsies and two of the four patients underwent renal biopsy for diagnosis.
  • One patient with a false-negative FDG-PET result showed fewer lymphoma cells in the bone marrow specimen than patients with concordant FDG-PET results.
  • [MeSH-major] Kidney / diagnostic imaging. Lymphoma, Large B-Cell, Diffuse / diagnostic imaging. Positron-Emission Tomography / methods. Positron-Emission Tomography / standards. Skin / diagnostic imaging

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  • (PMID = 18496649.001).
  • [ISSN] 0925-5710
  • [Journal-full-title] International journal of hematology
  • [ISO-abbreviation] Int. J. Hematol.
  • [Language] eng
  • [Publication-type] Journal Article; Validation Studies
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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41. Mensing CH, Krengel S, Tronnier M, Wolff HH: Reactive angioendotheliomatosis: is it 'intravascular histiocytosis'? J Eur Acad Dermatol Venereol; 2005 Mar;19(2):216-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Reactive angioendotheliomatosis: is it 'intravascular histiocytosis'?
  • We report the case of a 68-year-old female with reactive angioendotheliomatosis (RAE).
  • This case highlights the benign course of this condition and suggests that this entity might be an intravascular histiocytosis.
  • [MeSH-major] Endothelium, Vascular / pathology. Histiocytosis / pathology. Lymphoma, Non-Hodgkin / pathology. Skin Neoplasms / pathology

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  • (PMID = 15752295.001).
  • [ISSN] 0926-9959
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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42. Marini-Bettolo C, Lane R, Charles P, Naresh K, Nicholas R, Singh P, Cohen A, Mackie P, Roncaroli F: Myopathy secondary to intravascular large B-cell lymphoma. Neuromuscul Disord; 2009 Dec;19(12):856-9
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  • [Title] Myopathy secondary to intravascular large B-cell lymphoma.
  • We report a case of a 78-year-old woman presenting with progressive proximal muscle weakness mainly to lower limbs and myopathic EMG associated with intravascular large B-cell lymphoma.
  • Muscle biopsy showed myopathic changes, intravascular large B-cell lymphoma but no inflammation or fibre necrosis; the patient's serum cross-reacted with an unidentified nuclear antigen of approximately 45 kDa present in muscle and lymphoma cells.
  • Our case illustrates a myopathy associated with intravascular large B-cell lymphoma probably mediated by antibodies cross-reacting with a nuclear protein expressed by neoplastic cells and normal muscle.
  • [MeSH-major] Lymphoma, Large B-Cell, Diffuse / complications. Muscular Diseases / etiology

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  • (PMID = 19793654.001).
  • [ISSN] 1873-2364
  • [Journal-full-title] Neuromuscular disorders : NMD
  • [ISO-abbreviation] Neuromuscul. Disord.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Nuclear Proteins
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43. Kirke S, Angus B, Kesteven PJ, Calonje E, Simpson N: Localized reactive angioendotheliomatosis. Clin Exp Dermatol; 2007 Jan;32(1):45-7
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  • [Title] Localized reactive angioendotheliomatosis.
  • Further investigation revealed a very high anticardiolipin IgG titre and a left subclavian stenosis, presumably providing the reduced blood flow and relative hypoxia to allow microthromboses to occur in the presence of a thrombophilic tendency.
  • Similar clinical and histological features have been reported in patients with the antiphospholipid syndrome and cases of reactive angioendotheliomatosis (RAE).

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  • (PMID = 17004988.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Anticardiolipin
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44. Jiang QL, Pytel P, Rowin J: Disseminated intravascular large-cell lymphoma with initial presentation mimicking Guillain-Barré syndrome. Muscle Nerve; 2010 Jul;42(1):133-6
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  • [Title] Disseminated intravascular large-cell lymphoma with initial presentation mimicking Guillain-Barré syndrome.
  • We report a patient with intravascular large B-cell lymphoma who initially presented with acute ascending weakness and sensory changes.
  • Autopsy revealed disseminated intravascular large-cell lymphoma.
  • Intravascular large-cell lymphoma should be considered in the differential diagnosis of a rapidly evolving neuropathy associated with other organ involvement.
  • [MeSH-major] Guillain-Barre Syndrome / pathology. Lymphoma, Large-Cell, Immunoblastic / pathology
  • [MeSH-minor] Anti-Inflammatory Agents / therapeutic use. Autopsy. Axons / pathology. Diagnosis, Differential. Electrodiagnosis. Fatal Outcome. Humans. Male. Middle Aged. Muscle Strength / physiology. Muscle Weakness / etiology. Muscle, Skeletal / pathology. Neural Conduction / physiology. Peripheral Nerves / physiopathology. Peripheral Nervous System Diseases / etiology. Peripheral Nervous System Diseases / pathology. Pupil / physiology. Respiratory Insufficiency / etiology. Steroids / therapeutic use


45. Fujiwara A, Azuma T, Yamanouchi J, Narumi H, Yakushijin Y, Yasukawa M, Hato T, Hamaguchi N, Kadowaki T, Hamada H: [Intravascular large B-cell lymphoma presenting as interstitial lung disease]. Nihon Naika Gakkai Zasshi; 2007 Dec 10;96(12):2783-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Intravascular large B-cell lymphoma presenting as interstitial lung disease].
  • [MeSH-major] Lung Diseases, Interstitial / pathology. Lymphoma, B-Cell / pathology. Lymphoma, Large B-Cell, Diffuse / pathology. Vascular Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Lung / pathology. Middle Aged

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  • (PMID = 18203413.001).
  • [ISSN] 0021-5384
  • [Journal-full-title] Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine
  • [ISO-abbreviation] Nippon Naika Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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46. Mandal AK, Savvidou L, Slater RM, Cockett W, Wiggins J, Missouris CG: Angiotropic lymphoma: Associated chromosomal abnormalities. Eur J Intern Med; 2007 Sep;18(5):432-4
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  • [Title] Angiotropic lymphoma: Associated chromosomal abnormalities.
  • Intravascular angiotropic lymphoma (IVL) is a rare variant of non-Hodgkin's lymphoma.
  • Diagnosis in most cases is only achieved at post-mortem.
  • We present a patient with pyrexia of unknown origin diagnosed with angiotropic lymphoma by bone marrow biopsy.
  • B-cell angiotropic lymphoma is a rare, but important, cause of pyrexia of unknown origin and we advocate that prolonged fever that has resisted diagnosis should prompt histological and immunocytochemical examination of bone marrow to facilitate rapid diagnosis and early institution of treatment.

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  • (PMID = 17693234.001).
  • [ISSN] 0953-6205
  • [Journal-full-title] European journal of internal medicine
  • [ISO-abbreviation] Eur. J. Intern. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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47. Sawa N, Ubara Y, Katori H, Hoshino J, Suwabe T, Tagami T, Takemoto F, Miyakoshi S, Taniguchi S, Ohashi K, Takaichi K: Renal intravascular large B-cell lymphoma localized only within peritubular capillaries. Report of a case. Intern Med; 2007;46(10):657-62
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  • [Title] Renal intravascular large B-cell lymphoma localized only within peritubular capillaries. Report of a case.
  • We report a 35-year-old Japanese woman with intravascular large B-cell lymphoma diagnosed by percutaneous renal biopsy.
  • Percutaneous renal biopsy showed that an island-like atypical lymphoid cell accumulation was encircled with the peritubular capillary walls in many areas of the tubulo-interstitium, resulting in marked destruction of tubular structure.
  • Immunohistochemical analysis confirmed the diagnosis of intravascular large B-cell lymphoma.
  • Shortly after diagnosis, she was treated with rituximab, cyclophosphamide, hydroxydaunomycin, oncovin, and prednisolone, and her renal function and size improved.
  • Renal involvement by lymphoma has been classified into two categories: intraglomerular intravascular lymphoma and tubulointerstitial diffuse invasion type that is distinct from intravascular lymphoma.
  • For the latter cases with renal dysfunction and marked bilateral nephromegaly but without proteinuria, intravascular lymphoma within intra-peritublar capillaries should be considered as a possible diagnosis.
  • [MeSH-major] Capillaries / pathology. Kidney Glomerulus / pathology. Kidney Neoplasms / pathology. Lymphoma, B-Cell / pathology. Lymphoma, Large B-Cell, Diffuse / pathology

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  • (PMID = 17527039.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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48. Takizawa S, Shirasugi Y, Nakamura N, Nakagawa S, Tsuchiya T, Ando K, Takagi S: An atypical form of Asian variant of intravascular large B-cell lymphoma presenting with myelopathy alone for 4 months prior to pancytopenia. Intern Med; 2007;46(22):1879-80
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  • [Title] An atypical form of Asian variant of intravascular large B-cell lymphoma presenting with myelopathy alone for 4 months prior to pancytopenia.
  • [MeSH-major] Lymphoma, B-Cell / complications. Paraplegia / etiology. Spinal Cord Diseases / etiology

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  • (PMID = 18025772.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 4F4X42SYQ6 / Rituximab; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CHOP protocol
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49. Heinrich A, Vogelgesang S, Kirsch M, Khaw AV: Intravascular lymphomatosis presenting as rapidly progressive dementia. Eur Neurol; 2005;54(1):55-8
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  • [Title] Intravascular lymphomatosis presenting as rapidly progressive dementia.
  • [MeSH-major] Brain / pathology. Dementia, Multi-Infarct / etiology. Lymphoma, Large B-Cell, Diffuse / complications. Lymphoma, Large B-Cell, Diffuse / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Magnetic Resonance Angiography. Magnetic Resonance Imaging

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  • (PMID = 16118496.001).
  • [ISSN] 0014-3022
  • [Journal-full-title] European neurology
  • [ISO-abbreviation] Eur. Neurol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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50. Agusti A, Hernández P, Oliver V, García R, Alegre de Miquel V: [Angioendotheliomatosis associated with chronic venous insufficiency]. Actas Dermosifiliogr; 2010 Jun;101(5):464-6
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  • [Title] [Angioendotheliomatosis associated with chronic venous insufficiency].
  • [Transliterated title] Angioendoteliomatosis reactiva asociada a insuficiencia venosa crónica.

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  • (PMID = 20525497.001).
  • [ISSN] 1578-2190
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Spain
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51. Lannoo L, Smets S, Steenkiste E, Delforge M, Moerman P, Stroobants S, Knockaert D, Amant F: Intravascular large B-cell lymphoma of the uterus presenting as fever of unknown origin (FUO) and revealed by FDG-PET. Acta Clin Belg; 2007 May-Jun;62(3):187-90
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  • [Title] Intravascular large B-cell lymphoma of the uterus presenting as fever of unknown origin (FUO) and revealed by FDG-PET.
  • Non-Hodgkin's lymphoma (NHL) is a common cause of Fever of Unknown Origin (FUO) but the presentation as a gynaecologic malignancy is exceedingly rare.
  • To our knowledge, this represents the first report of an intravascular large B-cell lymphoma of the uterus presenting with fever of unknown origin.
  • After a standard clinical work-up for FUO, the endometrial curettage directed by the finding of a localized fluoro-deoxyglucose Positron Emission Tomography (FDG-PET) hot spot in the pelvic area, yielded material revealing an intr avascular B-cell lymphoma.
  • A total abdominal hysterectomy confirmed the presence of an intravascular large B-cell lymphoma in the lumina of small blood vessels of the uterus.
  • [MeSH-major] Fever of Unknown Origin / etiology. Lymphoma, B-Cell / radionuclide imaging. Lymphoma, Large B-Cell, Diffuse / radionuclide imaging. Positron-Emission Tomography. Uterine Neoplasms / radionuclide imaging. Uterus / blood supply. Vascular Neoplasms / radionuclide imaging

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  • (PMID = 17672184.001).
  • [ISSN] 1784-3286
  • [Journal-full-title] Acta clinica Belgica
  • [ISO-abbreviation] Acta Clin Belg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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52. Tsujimura A, Miyamura K, Kuwatsuka Y, Inamoto Y, Tokunaga M, Oba T, Terakura S, Suzuki R, Ito M, Murase T, Kodera Y: [Successful salvage therapy with cladribine and rituximab for a patient with a relapsed Asian variant of intravascular large B-cell lymphoma]. Rinsho Ketsueki; 2006 Oct;47(10):1387-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Successful salvage therapy with cladribine and rituximab for a patient with a relapsed Asian variant of intravascular large B-cell lymphoma].
  • The Asian variant of intravascular large B-cell lymphoma (AIVL) is a rare aggressive lymphoma characterized by various clinical symptoms, hemophagocytic syndrome and predominant growth within vessels.
  • A half year later, he presented with high fever, sweat, dementia and hepatosplenomegaly without lymphadenopathy.
  • A bone marrow biopsy showed prominent hemophagocytosis and immunological staining disclosed an augmented intrasinusal pattern of atypical large lymphocytes characteristic of the CD20+ and CD5+ phenotypes.
  • No serious adverse events were observed with the exception of grade 4 neutropenia and grade 3 thrombocytopenia.
  • CND-R therapy, which is effective for indolent lymphoma, may be one of the candidates in salvage therapy for relapsed AIVL.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Lymphoma, B-Cell / drug therapy. Salvage Therapy. Vascular Neoplasms / drug therapy

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  • (PMID = 17094579.001).
  • [ISSN] 0485-1439
  • [Journal-full-title] [Rinshō ketsueki] The Japanese journal of clinical hematology
  • [ISO-abbreviation] Rinsho Ketsueki
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 47M74X9YT5 / Cladribine; 4F4X42SYQ6 / Rituximab
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53. Martusewicz-Boros M, Wiatr E, Radzikowska E, Roszkowski-Sliz K, Langfort R: Pulmonary intravascular large B-cell lymphoma as a cause of severe hypoxemia. J Clin Oncol; 2007 May 20;25(15):2137-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pulmonary intravascular large B-cell lymphoma as a cause of severe hypoxemia.
  • [MeSH-major] Anoxia / complications. Lung Neoplasms / pathology. Lymphoma, B-Cell / pathology. Lymphoma, Large B-Cell, Diffuse / pathology. Vascular Neoplasms / pathology

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  • (PMID = 17513823.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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54. Koyama T, O'uchi T, Matsue K: Neurolymphomatosis involving the trigeminal nerve and deep peroneal nerve in a patient with relapsed intravascular large B-cell lymphoma. Eur J Haematol; 2010 Sep;85(3):275-6
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  • [Title] Neurolymphomatosis involving the trigeminal nerve and deep peroneal nerve in a patient with relapsed intravascular large B-cell lymphoma.
  • [MeSH-major] Lymphoma, Large B-Cell, Diffuse / pathology. Peroneal Nerve / pathology. Trigeminal Nerve / pathology. Vascular Neoplasms / pathology

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  • (PMID = 20528901.001).
  • [ISSN] 1600-0609
  • [Journal-full-title] European journal of haematology
  • [ISO-abbreviation] Eur. J. Haematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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55. Shimada K, Naoe T, Nakamura S, Kinoshita T, IVL study group: [Intravascular large B-cell lymphoma; recent advances and future perspectives]. Rinsho Ketsueki; 2010 Jul;51(7):447-53
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  • [Title] [Intravascular large B-cell lymphoma; recent advances and future perspectives].
  • [MeSH-major] Lymphoma, Large B-Cell, Diffuse. Vascular Neoplasms

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  • (PMID = 20693761.001).
  • [ISSN] 0485-1439
  • [Journal-full-title] [Rinshō ketsueki] The Japanese journal of clinical hematology
  • [ISO-abbreviation] Rinsho Ketsueki
  • [Language] jpn
  • [Publication-type] Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 4F4X42SYQ6 / Rituximab
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56. Albrecht R, Krebs B, Reusche E, Nagel M, Lencer R, Kretzschmar HA: Signs of rapidly progressive dementia in a case of intravascular lymphomatosis. Eur Arch Psychiatry Clin Neurosci; 2005 Aug;255(4):232-5
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  • [Title] Signs of rapidly progressive dementia in a case of intravascular lymphomatosis.
  • Intravascular lymphomatosis (IVL), a rare type of non-Hodgkin's lymphoma, is an uncommon cause of progressive dementia, usually followed by death within a few months of onset of clinical disease.
  • Here we present IVL in a 78-year-old woman with findings leading to the clinical diagnosis of vascular dementia with sudden beginning and positive 14-3-3 protein in the CSF, commonly reported in Creutzfeldt-Jakob disease (CJD).
  • [MeSH-major] Dementia / psychology. Lymphoma / psychology
  • [MeSH-minor] 14-3-3 Proteins / cerebrospinal fluid. Aged. Brain / pathology. Diagnosis, Differential. Disease Progression. Fatal Outcome. Female. Humans. Vasculitis, Central Nervous System / diagnosis. Vasculitis, Central Nervous System / pathology

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  • (PMID = 15565300.001).
  • [ISSN] 0940-1334
  • [Journal-full-title] European archives of psychiatry and clinical neuroscience
  • [ISO-abbreviation] Eur Arch Psychiatry Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / 14-3-3 Proteins
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57. Yang H, Ahmed I, Mathew V, Schroeter AL: Diffuse dermal angiomatosis of the breast. Arch Dermatol; 2006 Mar;142(3):343-7
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  • [Title] Diffuse dermal angiomatosis of the breast.
  • BACKGROUND: Diffuse dermal angiomatosis is rare and usually considered a variant of reactive angioendotheliomatosis.
  • Two patients with breast involvement have been described; however, neither had a relevant medical history or a vaso-occlusive disorder, but both had large pendulous breasts, and 1 was positive for IgM anticardiolipin and antinuclear antibodies.
  • Biopsy of the lesion showed diffuse proliferation of additional endothelial cells and small bland vessels within the papillary and upper reticular dermis.
  • Diffuse dermal angiomatosis was diagnosed.
  • A literature review suggested that a history of heavy smoking, in addition to a history of vascular disease, may be important in the pathogenesis of diffuse dermal angiomatosis.
  • CONCLUSIONS: Clinical acumen is crucial to diagnose diffuse angiomatosis of the breast.

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  • [CommentIn] Arch Dermatol. 2006 Mar;142(3):362-4 [16549715.001]
  • (PMID = 16549710.001).
  • [ISSN] 0003-987X
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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58. Rashid R, Johnson RJ, Morris S, Dickinson H, Czyz J, O'Connor SJ, Owen RG: Intravascular large B-cell lymphoma associated with a near-tetraploid karyotype, rearrangement of BCL6, and a t(11;14)(q13;q32). Cancer Genet Cytogenet; 2006 Dec;171(2):101-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intravascular large B-cell lymphoma associated with a near-tetraploid karyotype, rearrangement of BCL6, and a t(11;14)(q13;q32).
  • Chromosome analysis of a patient with intravascular large B-cell lymphoma (IVL) revealed a complex, near-tetraploid karyotype with 83 chromosomes.
  • Abnormality of 3q was also evident.
  • [MeSH-major] Chromosomes, Human, Pair 11. Chromosomes, Human, Pair 14. DNA-Binding Proteins / genetics. Lymphoma, B-Cell / genetics. Lymphoma, Large B-Cell, Diffuse / genetics. Polyploidy. Translocation, Genetic. Vascular Neoplasms / genetics

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  • (PMID = 17116487.001).
  • [ISSN] 0165-4608
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / BCL6 protein, human; 0 / DNA-Binding Proteins
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59. Bozzoli V, Tisi MC, D'Alò F, Massini G, Mansueto G, Vannata B, Arena V, Larocca LM, Teofili L, Leone G, Hohaus S: Intravascular large B cell lymphoma: when lymphoma is suspected but routine diagnostic work-up is negative. Leuk Lymphoma; 2009 Nov;50(11):1900-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intravascular large B cell lymphoma: when lymphoma is suspected but routine diagnostic work-up is negative.
  • [MeSH-major] Lymphoma / diagnosis. Lymphoma, Large B-Cell, Diffuse / diagnosis. Vascular Neoplasms / diagnosis
  • [MeSH-minor] Aged. Antigens, CD20 / analysis. Autopsy. Diagnosis, Differential. Fatal Outcome. Female. Humans. Immunohistochemistry. Male

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  • [CommentIn] Leuk Lymphoma. 2009 Nov;50(11):1742-3 [19883304.001]
  • (PMID = 19883320.001).
  • [ISSN] 1029-2403
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD20
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60. Pallure V, Dandurand M, Stoebner PE, Habib F, Colonna G, Meunier L: [Intravascular B-cell lymphoma with febrile inflammatory lymphoedema of the lower limbs and lower back]. Ann Dermatol Venereol; 2008 Apr;135(4):299-303
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Intravascular B-cell lymphoma with febrile inflammatory lymphoedema of the lower limbs and lower back].
  • [Transliterated title] Lymphome B intravasculaire à type de lymphoedème inflammatoire fébrile des membres inférieurs et des lombes.
  • BACKGROUND: Intravascular lymphomas are diffuse large-cell lymphomas belonging to a group of high-grade non-Hodgkin's lymphomas and are generally of phenotype B.
  • PATIENTS AND METHODS: We report the case of an 80-year-old woman with cutaneous intravascular B-cell lymphoma as revealed by an isolated episode of febrile bilateral inflammatory lymphoedema.
  • DISCUSSION: Diagnosis of these tumours is rendered difficult by the clinical polymorphism and multifocal nature of lymphocytic proliferations.
  • In the present case, diagnosis was based on histology results since presentation of the disease in the form of bilateral inflammatory oedema of the lower limbs is not sufficient to establish lymphoma.
  • [MeSH-major] Lymphedema / complications. Lymphedema / pathology. Lymphoma, B-Cell / complications

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  • (PMID = 18420078.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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61. Deisch J, Fuda FB, Chen W, Karandikar N, Arbini AA, Zhou XJ, Wang HY: Segmental tandem triplication of the MLL gene in an intravascular large B-cell lymphoma with multisystem involvement: a comprehensive morphologic, immunophenotypic, cytogenetic, and molecular cytogenetic antemortem study. Arch Pathol Lab Med; 2009 Sep;133(9):1477-82
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  • [Title] Segmental tandem triplication of the MLL gene in an intravascular large B-cell lymphoma with multisystem involvement: a comprehensive morphologic, immunophenotypic, cytogenetic, and molecular cytogenetic antemortem study.
  • An association between intravascular large B-cell lymphoma (IVLBCL) and the mixed lineage leukemia (MLL) gene has never been demonstrated.
  • [MeSH-major] Chromosomes, Human, Pair 11 / genetics. Lymphoma, Large B-Cell, Diffuse / genetics. Myeloid-Lymphoid Leukemia Protein / genetics. Tandem Repeat Sequences / genetics. Trisomy / genetics

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  • (PMID = 19722759.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Biomarkers, Tumor; 0 / MLL protein, human; 149025-06-9 / Myeloid-Lymphoid Leukemia Protein; 4F4X42SYQ6 / Rituximab; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; EC 2.1.1.43 / Histone-Lysine N-Methyltransferase; VB0R961HZT / Prednisone; CHOP protocol
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62. Nakazato T, Suzuki K, Mihara A, Sanada Y, Yoshida S, Kakimoto T: [Intravascular large B-cell lymphoma with pontine involvement successfully treated with R-hyper-CVAD/R-MTX-Ara-C regimen]. Rinsho Ketsueki; 2010 Feb;51(2):148-52
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  • [Title] [Intravascular large B-cell lymphoma with pontine involvement successfully treated with R-hyper-CVAD/R-MTX-Ara-C regimen].
  • Malignant lymphoma was suspected, but histological diagnosis was difficult because superficial lymph nodes could not be palpated.
  • Histological examination of the bone marrow biopsy specimen demonstrated the proliferation of large atypical lymphoid cells positive for CD20 and CD79a in the small capillaries, leading to the diagnosis of intravascular large B-cell lymphoma (IVLBCL).
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Brain Stem Neoplasms / drug therapy. Brain Stem Neoplasms / pathology. Lymphoma, Large B-Cell, Diffuse / drug therapy. Vascular Neoplasms / drug therapy
  • [MeSH-minor] Cyclophosphamide / administration & dosage. Cytarabine / administration & dosage. Dexamethasone / administration & dosage. Doxorubicin / administration & dosage. Female. Humans. Methotrexate / administration & dosage. Middle Aged. Neoplasm Invasiveness. Remission Induction. Treatment Outcome. Vincristine / administration & dosage

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  • (PMID = 20379108.001).
  • [ISSN] 0485-1439
  • [Journal-full-title] [Rinshō ketsueki] The Japanese journal of clinical hematology
  • [ISO-abbreviation] Rinsho Ketsueki
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 04079A1RDZ / Cytarabine; 5J49Q6B70F / Vincristine; 7S5I7G3JQL / Dexamethasone; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; YL5FZ2Y5U1 / Methotrexate; CVAD protocol
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63. Boukari L, Caux F, Levy A, Braun T, Fain O: [Intravascular B cell lymphoma]. Rev Prat; 2009 Sep 20;59(7):904
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Intravascular B cell lymphoma].
  • [Transliterated title] Lymphome angiotrope B a grandes cellules.
  • [MeSH-major] Lymphoma, B-Cell / pathology. Vascular Neoplasms / pathology

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  • (PMID = 19839453.001).
  • [ISSN] 0035-2640
  • [Journal-full-title] La Revue du praticien
  • [ISO-abbreviation] Rev Prat
  • [Language] fre
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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64. Kitanaka A, Kubota Y, Imataki O, Ohnishi H, Fukumoto T, Kurokohchi K, Tanaka T: Intravascular large B-cell lymphoma with FDG accumulation in the lung lacking CT/(67)gallium scintigraphy abnormality. Hematol Oncol; 2009 Mar;27(1):46-9
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  • [Title] Intravascular large B-cell lymphoma with FDG accumulation in the lung lacking CT/(67)gallium scintigraphy abnormality.
  • Intravascular large B-cell lymphoma (IVLBCL) is a rare lymphoma characterized by the presence of large tumour cells within the blood vessels.
  • It has been considered that IVLBCL is a highly malignant disease with poor prognosis.
  • However, it has been shown that a therapeutic effect resembling that of conventional B-cell lymphomas may be obtained with the application of systemic chemotherapy at the early stage of this disease.
  • Although involvement in the lung is often detected at autopsy, early diagnosis is quite difficult.
  • In this report, we present a case of IVLBCL with pulmonary involvement where 18-fluoro-deoxyglucose positron emission tomography (FDG-PET) was useful in the early diagnosis.
  • We propose that FDG-PET is a powerful tool for the early diagnosis of IVLBCL with pulmonary involvement, if the possibility of this disease presents in the patient with respiratory symptoms without abnormal findings by CT and (67)gallium scintigraphy.
  • [MeSH-major] Lung Neoplasms / radiography. Lymphoma, B-Cell / radiography. Lymphoma, B-Cell / radionuclide imaging
  • [MeSH-minor] Female. Fluorodeoxyglucose F18. Gallium Radioisotopes. Humans. Lung / metabolism. Lung / pathology. Middle Aged. Neoplasm Invasiveness. Prognosis. Splenomegaly / radiography. Splenomegaly / radionuclide imaging. Tomography, X-Ray Computed

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  • [Copyright] Copyright 2009 John Wiley & Sons, Ltd.
  • (PMID = 18819161.001).
  • [ISSN] 1099-1069
  • [Journal-full-title] Hematological oncology
  • [ISO-abbreviation] Hematol Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Gallium Radioisotopes; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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65. Askarian F, Xu D: Adrenal enlargement and insufficiency: a common presentation of intravascular large B-cell lymphoma. Am J Hematol; 2006 Jun;81(6):411-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adrenal enlargement and insufficiency: a common presentation of intravascular large B-cell lymphoma.
  • Intravascular large B-cell lymphoma (IVLL) is a rare subtype of extranodal diffuse large B-cell lymphoma and is very difficult to diagnose in patients antemortem due to nonspecific presentation of the disease.
  • [MeSH-major] Adrenal Glands / ultrastructure. Adrenal Insufficiency / pathology. Lymphoma, B-Cell / pathology. Lymphoma, Large B-Cell, Diffuse / pathology

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  • (PMID = 16680734.001).
  • [ISSN] 0361-8609
  • [Journal-full-title] American journal of hematology
  • [ISO-abbreviation] Am. J. Hematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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66. Ruud KJ, Scheie D, Kerty E: [A 64-year old man with cognitive impairment and gait disturbance]. Tidsskr Nor Laegeforen; 2007 May 3;127(9):1210-1
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  • Intravascular lymphomatosis is a rare disease, characterized by occlusion of small arterioles and veins by malignant lymphoma cells.
  • Diagnosis is often delayed and made post mortem.
  • Intravascular lymphomatosis should be considered in patients with a combination of rapidly developing encephalopathy and focal neurological signs.
  • [MeSH-major] Brain Neoplasms / diagnosis. Cognition Disorders / diagnosis. Gait. Lymphoma, B-Cell / diagnosis. Lymphoma, Large B-Cell, Diffuse / diagnosis. Vascular Neoplasms / diagnosis
  • [MeSH-minor] Autopsy. Brain / blood supply. Brain / pathology. Diagnosis, Differential. Disease Progression. Fatal Outcome. Humans. Male. Middle Aged

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  • [CommentIn] Tidsskr Nor Laegeforen. 2007 May 3;127(9):1212 [17486713.001]
  • (PMID = 17486712.001).
  • [ISSN] 0807-7096
  • [Journal-full-title] Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række
  • [ISO-abbreviation] Tidsskr. Nor. Laegeforen.
  • [Language] nor
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Norway
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67. Jardin F, Callonnec F, Contentin N, Picquenot JM, Gueit I, Héron F, Bastard C, Tilly H: Intravascular large B-Cell lymphoma with bone marrow involvement and superior sagittal sinus thrombosis: report of a case successfully treated with a CHOP/rituximab combination regimen. Clin Lymphoma; 2005 Jun;6(1):46-9
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  • [Title] Intravascular large B-Cell lymphoma with bone marrow involvement and superior sagittal sinus thrombosis: report of a case successfully treated with a CHOP/rituximab combination regimen.
  • Intravascular large B-cell lymphoma (ILBCL) is a rare subtype of diffuse large B-cell lymphoma (as currently recognized by the World Health Organization classification) and is characterized by proliferation of mature B-cells within the lumina of small and medium vessels.
  • The diagnosis of ILBCL was established by a bone marrow biopsy that showed CD20+ tumor cells confined within the lumina of sinuses.
  • Magnetic resonance imaging of the brain revealed multiple high-signal areas in the periventricular white matter above the tentorium.
  • This observation highlights an unusual vascular aspect of ILBCL and the efficacy of the current standard treatment for this age group (CHOP/rituximab) in this particularly aggressive lymphoma subtype.
  • [MeSH-major] Antibodies, Monoclonal / therapeutic use. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bone Marrow / pathology. Lymphoma, B-Cell / drug therapy

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  • (PMID = 15989707.001).
  • [ISSN] 1526-9655
  • [Journal-full-title] Clinical lymphoma
  • [ISO-abbreviation] Clin Lymphoma
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antineoplastic Agents; 4F4X42SYQ6 / Rituximab; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CHOP protocol
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68. Gaul C, Hanisch F, Neureiter D, Behrmann C, Neundörfer B, Winterholler M: Intravascular lymphomatosis mimicking disseminated encephalomyelitis and encephalomyelopathy. Clin Neurol Neurosurg; 2006 Jul;108(5):486-9
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  • [Title] Intravascular lymphomatosis mimicking disseminated encephalomyelitis and encephalomyelopathy.
  • Intravascular lymphomatosis is characterized by the presence of large lymphoma cells predominantly within small vessels.
  • Autopsy of both cases revealed an intravascular lymphomatosis.
  • An intravascular lymphomatosis should be considered when a meningoencephalitic symptomatology is unclear.
  • A biopsy of different organs including the brain and leptomeninges should not be delayed to ensure ante mortem diagnosis and to initiate chemotherapy.
  • [MeSH-major] Encephalomyelitis, Acute Disseminated / diagnosis. Leigh Disease / diagnosis. Lymphoma, B-Cell / pathology. Vascular Neoplasms / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Fatal Outcome. Humans. L-Lactate Dehydrogenase / blood. Magnetic Resonance Imaging. Male. Middle Aged. Severity of Illness Index

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  • (PMID = 16720222.001).
  • [ISSN] 0303-8467
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] EC 1.1.1.27 / L-Lactate Dehydrogenase
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69. Yin W, Li M, Gao Z, Huang F, Da J, Liu C: Intravascular large B-cell lymphoma with involvement of the abdominal subcutis: a case report and literature review. Int J Hematol; 2009 Apr;89(3):348-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intravascular large B-cell lymphoma with involvement of the abdominal subcutis: a case report and literature review.
  • Intravascular large B-cell lymphoma (IVLBCL) is a rare subtype of diffuse large B-cell lymphoma (DLBCL).
  • [MeSH-major] Lymphoma, Large B-Cell, Diffuse / pathology. Microcirculation. Neovascularization, Pathologic / pathology

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  • [ISSN] 1865-3774
  • [Journal-full-title] International journal of hematology
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70. Lee HB, Pulido JS, Buettner H, Salomão D, Zent CS, Link TP: Intravascular B-cell lymphoma (angiotropic lymphoma) with choroidal involvement. Arch Ophthalmol; 2006 Sep;124(9):1357-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intravascular B-cell lymphoma (angiotropic lymphoma) with choroidal involvement.
  • [MeSH-major] Choroid Neoplasms / pathology. Lung Neoplasms / pathology. Lymphoma, B-Cell / pathology. Lymphoma, Large B-Cell, Diffuse / pathology

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  • [ErratumIn] Arch Ophthalmol. 2006 Nov;124(11):1565. Lee, B Harold [corrected to Lee, H B Harold]
  • (PMID = 16966639.001).
  • [ISSN] 0003-9950
  • [Journal-full-title] Archives of ophthalmology (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD20; 0 / Biomarkers, Tumor
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71. Magi GE, Di Pasquale S, Renzoni G: Cutaneous lymphomatoid granulomatosis (angiotropic lymphoma) in a dog: immunophenotyping analysis. Vet Res Commun; 2009 Sep;33 Suppl 1:145-7
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  • [Title] Cutaneous lymphomatoid granulomatosis (angiotropic lymphoma) in a dog: immunophenotyping analysis.
  • [MeSH-major] Dog Diseases / diagnosis. Immunophenotyping / veterinary. Lymphomatoid Granulomatosis / veterinary

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  • [ISSN] 1573-7446
  • [Journal-full-title] Veterinary research communications
  • [ISO-abbreviation] Vet. Res. Commun.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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72. Mihaljevic B, Sternic N, Skender Gazibara M, Sretenovic A, Antic D, Terzic T, Kostic V: Intravascular large B-cell lymphoma of central nervous system - a report of two cases and literature review. Clin Neuropathol; 2010 Jul-Aug;29(4):233-8
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  • [Title] Intravascular large B-cell lymphoma of central nervous system - a report of two cases and literature review.
  • Intravascular large B-cell lymphoma (IVL) is a rare form of diffuse large B cell lymphoma (DBCL) frequently presenting with skin and/or central nervous system (CNS) involvement.
  • Neuroimaging discloses CNS involvement only in half of patients with neurological symptoms because there are no pathognomonic neuroradiological findings for IVL; ischemic foci are the most common presentation pattern and therefore vasculitis is the most common differential diagnosis.
  • According to all mentioned data, diagnosis of CNS IVL requires a histopathological confirmation.
  • In younger patients with unfavorable features the high-dose chemotherapy with autologous stem cell transplantation should be used.
  • [MeSH-major] Brain Neoplasms / pathology. Lymphoma, Large B-Cell, Diffuse / pathology

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  • (PMID = 20569674.001).
  • [ISSN] 0722-5091
  • [Journal-full-title] Clinical neuropathology
  • [ISO-abbreviation] Clin. Neuropathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 18
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73. Kameoka Y, Takahashi N, Tagawa H, Fujishima N, Yoshioka T, Saito H, Hirokawa M, Ichinohasama R, Sawada K: A case of intravascular large B-cell lymphoma of the cutaneous variant: the first case in Asia. Int J Hematol; 2010 Jan;91(1):146-8
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  • [Title] A case of intravascular large B-cell lymphoma of the cutaneous variant: the first case in Asia.
  • [MeSH-major] Lymphoma, B-Cell / pathology. Lymphoma, Large B-Cell, Diffuse / pathology. Skin Neoplasms / pathology. Vascular Neoplasms / pathology

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  • [Cites] J Clin Oncol. 2007 Jul 20;25(21):3168-73 [17577023.001]
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  • (PMID = 20012511.001).
  • [ISSN] 1865-3774
  • [Journal-full-title] International journal of hematology
  • [ISO-abbreviation] Int. J. Hematol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Japan
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74. Zhao XF, Sands AM, Ostrow PT, Halbiger R, Conway JT, Bagg A: Recurrence of nodal diffuse large B-cell lymphoma as intravascular large B-cell lymphoma: is an intravascular component at initial diagnosis predictive? Arch Pathol Lab Med; 2005 Mar;129(3):391-4
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  • [Title] Recurrence of nodal diffuse large B-cell lymphoma as intravascular large B-cell lymphoma: is an intravascular component at initial diagnosis predictive?
  • We report a case of a 59-year-old man who first presented with a nodal diffuse large B-cell lymphoma that later relapsed as an intravascular large B-cell lymphoma.
  • In the initial biopsy specimen, a few intranodal small vessels that contained large lymphoma cells were noted.
  • Two years after the initial diagnosis of nodal diffuse large B-cell lymphoma, the patient presented with a rapid onset of multiorgan failure, which at autopsy was shown to be due to intravascular large B-cell lymphoma.
  • To our knowledge, this is the first report of a nodal large B-cell lymphoma that relapsed as an intravascular large B-cell lymphoma.
  • Although this report is of only a single case, the presence of a relatively inconspicuous intravascular component in an otherwise typical nodal large B-cell lymphoma may be predictive and could affect clinical decisions regarding diagnosis, monitoring, and prognosis of such lymphomas.
  • [MeSH-major] Lymphoma, B-Cell / diagnosis. Lymphoma, Large B-Cell, Diffuse / diagnosis. Neoplasm Recurrence, Local / diagnosis. Vascular Neoplasms / diagnosis

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  • (PMID = 15737037.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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75. Ohshima R, Tomita N, Motohashi K, Ieda A, Hyou R, Fujisawa S, Fujita H, Sakai R, Koharazawa H, Kuwabara H, Kanamori H, Ishigatsubo Y: [Clinical course of 8 patients with intravascular large B-cell lymphoma diagnosed while alive]. Rinsho Ketsueki; 2005 Jun;46(6):453-7
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  • [Title] [Clinical course of 8 patients with intravascular large B-cell lymphoma diagnosed while alive].
  • We retrospectively evaluated the diagnosis and clinical courses of 8 patients with intravascular large B-cell lymphoma (IVL) diagnosed while they were alive.
  • Most complaints at diagnosis were fever or dyspnea.
  • The diagnosis of IVL was confirmed by biopsy specimens from the bone marrow in 4, lung in 2, muscle, adrenal gland, and lymph node in 1 case, respectively.
  • In suspicious cases, it is important to bear IVL in mind and examine bone marrow biopsies for an early diagnosis.
  • [MeSH-major] Lymphoma, B-Cell / diagnosis. Lymphoma, Large B-Cell, Diffuse / diagnosis. Vascular Neoplasms / diagnosis
  • [MeSH-minor] Aged. Aged, 80 and over. Antibodies, Monoclonal / administration & dosage. Antibodies, Monoclonal, Murine-Derived. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bone Marrow / pathology. Early Diagnosis. Female. Humans. Male. Middle Aged. Neoplasm Staging. Prognosis. Rituximab

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  • (PMID = 16447727.001).
  • [ISSN] 0485-1439
  • [Journal-full-title] [Rinshō ketsueki] The Japanese journal of clinical hematology
  • [ISO-abbreviation] Rinsho Ketsueki
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 4F4X42SYQ6 / Rituximab
  • [Number-of-references] 17
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76. Yao X, Saad A, Chitambar CR: Intravascular large B-cell lymphoma, an exclusively small vessel disease? A case report and review of literature. Leuk Res; 2010 Oct;34(10):e275-7
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  • [Title] Intravascular large B-cell lymphoma, an exclusively small vessel disease? A case report and review of literature.
  • [MeSH-major] Lymphoma, Large B-Cell, Diffuse / diagnosis. Vascular Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged. Positron-Emission Tomography

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  • (PMID = 20542564.001).
  • [ISSN] 1873-5835
  • [Journal-full-title] Leukemia research
  • [ISO-abbreviation] Leuk. Res.
  • [Language] eng
  • [Publication-type] Letter; Review
  • [Publication-country] England
  • [Number-of-references] 11
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77. Nokubi M, Yamamoto T, Andou Y, Nakano I: [Intravascular lymphomatosis complicated with marked tumoral thrombosis of the brain venous system including dural sinuses. An autopsy case report with 5 months' follow-up and fatal outcome]. Rinsho Shinkeigaku; 2006 Oct;46(10):707-11
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  • [Title] [Intravascular lymphomatosis complicated with marked tumoral thrombosis of the brain venous system including dural sinuses. An autopsy case report with 5 months' follow-up and fatal outcome].
  • Under the diagnosis of dural sinus thrombosis accompanied with rhinitis, antibiotics and anticlotting drugs were administered.
  • Autopsy revealed that large B-cell lymphoma occupied the cavernous sinuses and made a mass involving sella turcica, left sphenoid bone, hypophysis.
  • Intima of the brain venous system, however, was widely involved by lymphoma cells admixed with thrombi, which produced occlusion of the leptomeningeal veins and dural sinuses.
  • It seems that a unique type of thrombosis, i.e. tumoral thrombosis of leptomeningeal veins and dural sinuses, caused by intravascular lymphoma resulted in fatal outcome with multiple brain lesions like hemorrhagic infarct.
  • It may be suggested that intravascular lymphomatosis can cause marked phlebothrombosis of the brain and can mimic dural sinus thrombosis.
  • [MeSH-major] Brain / blood supply. Brain Neoplasms / pathology. Lymphoma, B-Cell / pathology. Sinus Thrombosis, Intracranial / pathology. Vascular Neoplasms / pathology
  • [MeSH-minor] Fatal Outcome. Humans. Male. Middle Aged. Neoplasm Invasiveness

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  • (PMID = 17323780.001).
  • [ISSN] 0009-918X
  • [Journal-full-title] Rinshō shinkeigaku = Clinical neurology
  • [ISO-abbreviation] Rinsho Shinkeigaku
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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78. Ferry JA, Sohani AR, Longtine JA, Schwartz RA, Harris NL: HHV8-positive, EBV-positive Hodgkin lymphoma-like large B-cell lymphoma and HHV8-positive intravascular large B-cell lymphoma. Mod Pathol; 2009 May;22(5):618-26
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  • [Title] HHV8-positive, EBV-positive Hodgkin lymphoma-like large B-cell lymphoma and HHV8-positive intravascular large B-cell lymphoma.
  • Human herpesvirus type 8 (HHV8), also known as Kaposi's sarcoma-associated herpesvirus, is a human gamma herpesvirus that underlies the pathogenesis of Kaposi's sarcoma, primary effusion lymphoma and multicentric Castleman's disease.
  • We recently encountered two cases of HHV8-positive large B-cell lymphoma with features not previously described.
  • The first patient was a 61-year-old immunocompetent man with an enlarged cervical lymph node containing scattered large, bizarre cells in a reactive background of lymphocytes, plasma cells and scattered regressed follicles resembling those of hyaline-vascular Castleman's disease.
  • The appearance suggested classical Hodgkin's lymphoma, but the large cells were negative for CD15, CD30, CD20 and CD3, and positive for MUM1/IRF4, EMA, HHV8, EBER and dim IgM lambda.
  • At autopsy an intravascular large B-cell lymphoma that was positive for MUM1/IRF4, HHV8 and IgM lambda, and negative for CD20 and EBER involved multiple organs, including lung, heart, kidney, liver and spleen.
  • [MeSH-major] Epstein-Barr Virus Infections / pathology. Herpesviridae Infections / pathology. Lymphoma, Large B-Cell, Diffuse / pathology. Lymphoma, Large B-Cell, Diffuse / virology

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  • (PMID = 19287457.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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79. Wong P, Moonie A, Dennett X, Anpalahan M: A case of intravascular lymphomatosis (IVL) presenting as polyneuropathy. Eur J Intern Med; 2006 Jan;17(1):59-60
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  • [Title] A case of intravascular lymphomatosis (IVL) presenting as polyneuropathy.
  • Intravascular lymphomatosis (IVL) is a rare, yet important, cause of a variety of unexplained neurological syndromes.
  • In this clinical context, the only clue to the diagnosis may be a significantly raised plasma lactate dehydrogenase (LDH) on a background of clinical features of a systemic illness.

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  • (PMID = 16378890.001).
  • [ISSN] 0953-6205
  • [Journal-full-title] European journal of internal medicine
  • [ISO-abbreviation] Eur. J. Intern. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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80. Breshears MA, Johnson BJ: Systemic reactive angioendotheliomatosis-like syndrome in a steer presumed to be persistently infected with bovine viral diarrhea virus. Vet Pathol; 2008 Sep;45(5):645-9
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  • [Title] Systemic reactive angioendotheliomatosis-like syndrome in a steer presumed to be persistently infected with bovine viral diarrhea virus.
  • Unusual proliferative intravascular lesions were seen in multiple organs of a 2-year-old Corriente steer presumed to be persistently infected with bovine viral diarrhea virus (BVDV), based on widespread immunohistochemical detection of BVDV antigen.
  • Distribution and character of the intraluminal proliferations are strikingly similar to those described in feline systemic reactive angioendotheliomatosis, a rare entity of unknown cause.
  • The presence of occasional intravascular thrombi suggests that the proliferative vasculopathy was associated with an underlying thrombotic process with immunohistochemical similarities to thrombotic thrombocytopenic purpura of humans.
  • The role of persistent BVDV infection in the formation of the intravascular lesions is unknown.

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  • (PMID = 18725468.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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81. Srivatsa S, Sharma J, Logani S: Intravascular lymphoma: an unusual diagnostic outcome of an incidentally detected adrenal mass. Endocr Pract; 2008 Oct;14(7):884-8
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  • [Title] Intravascular lymphoma: an unusual diagnostic outcome of an incidentally detected adrenal mass.
  • OBJECTIVE: To describe a rare diagnosis of intravascular lymphoma in a patient presenting with an incidentally discovered adrenal mass.
  • Since the lesion lacked high intensity and the biochemical testing results did not suggest a pheochromocytoma, it was deemed likely that the mass was a malignant lesion of the left adrenal gland.
  • Morphologic and immunohistochemical findings were consistent with a large B-cell lymphoma, which by virtue of its near exclusive distribution in vascular spaces, was consistent with the diagnosis of intravascular large B-cell lymphoma.
  • CONCLUSION: Intravascular large B-cell lymphoma should be included in the differential diagnosis of an incidentally detected adrenal mass even though the diagnosis is rare.
  • [MeSH-major] Adrenal Gland Diseases / diagnosis. Adrenal Gland Diseases / pathology. Lymphoma, Large B-Cell, Diffuse / diagnosis. Lymphoma, Large B-Cell, Diffuse / pathology

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  • (PMID = 18996818.001).
  • [ISSN] 1934-2403
  • [Journal-full-title] Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
  • [ISO-abbreviation] Endocr Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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82. Yin XR, Liu H, Chen HQ: [Intravascular lymphomatosis of the prostate gland]. Zhonghua Bing Li Xue Za Zhi; 2005 Mar;34(3):189-90
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  • [Title] [Intravascular lymphomatosis of the prostate gland].
  • [MeSH-major] Lymphoma, B-Cell / pathology. Prostate / pathology. Prostatic Hyperplasia / pathology

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  • (PMID = 15938838.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD20; EC 3.1.3.48 / Antigens, CD45
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83. Szuba A, Koba M, Rzeszutko M, Rzeszutko W, Dziegiel P, Loboda A, Dulak J, Andrzejak R: Cutaneous angiogenesis in patient with intravascular lymphoma (IVL): A case report. Dermatol Online J; 2010;16(8):2
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  • [Title] Cutaneous angiogenesis in patient with intravascular lymphoma (IVL): A case report.
  • We present a case of widespread cutaneous telangiectasias in a patient with a B-cell intravascular lymphoma most likely representing tumor-induced angiogenesis.
  • The patient presented with a rapid onset of large cutaneous telangiectasias and skin edema, followed by the development of multiorgan failure.
  • We describe difficulties with the ante-mortem diagnosis in the patient with predominant, clinically observed, skin lesions.
  • The final diagnosis of intravascular malignant lymphoma (IVL) was established post-mortem after morphological and immunohistochemical studies of the autopsy material.
  • [MeSH-major] Lymphoma, Large B-Cell, Diffuse / diagnosis. Neovascularization, Pathologic / diagnosis. Skin Neoplasms / blood supply. Skin Neoplasms / diagnosis. Telangiectasis / diagnosis. Vascular Neoplasms / diagnosis
  • [MeSH-minor] Aged. Antigens, CD20 / analysis. Antigens, CD79 / analysis. Fatal Outcome. Female. Humans. Multiple Organ Failure / diagnosis. Multiple Organ Failure / pathology

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  • (PMID = 20804679.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD20; 0 / Antigens, CD79
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84. Sips GJ, Amory CF, Delman BN, Kleinman GM, Lipsey LR, Tuhrim S: Intravascular lymphomatosis of the brain in a patient with myelodysplastic syndrome. Nat Rev Neurol; 2009 May;5(5):288-92
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  • [Title] Intravascular lymphomatosis of the brain in a patient with myelodysplastic syndrome.
  • BACKGROUND: A 77-year-old retired research pharmacologist with a long-standing history of anemia and a recent pathologically confirmed diagnosis of myelodysplastic syndrome was referred to a stroke unit for evaluation of slowly progressive cognitive deterioration, confusion and paroxysmal stroke-like episodes.
  • DIAGNOSIS: Intravascular lymphomatosis of the brain.
  • [MeSH-major] Brain Neoplasms / complications. Lymphoma, B-Cell / complications. Myelodysplastic Syndromes / complications


85. Nakamura Y, Nakamagoe K, Kawachi Y, Hosaka A, Mukai H, Chiba S, Otsuka F, Tamaoka A: Intravascular large B cell lymphoma with neurological symptoms diagnosed on the basis of a senile angioma-like eruption. BMJ Case Rep; 2009;2009
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  • [Title] Intravascular large B cell lymphoma with neurological symptoms diagnosed on the basis of a senile angioma-like eruption.
  • Intravascular large B cell lymphoma (IVLBCL) presents various neurological symptoms, and the prognosis frequently deteriorates with a delay in diagnosis.
  • In addition, for the diagnosis of IVLBCL, invasive biopsies are generally performed in main organs, such as the brain.
  • We report a case of IVLBCL in which an early diagnosis was enabled by skin biopsy.
  • In cases in which IVLBCL could be suspected, an active search and biopsy of skin lesions, including an eruption of this type, are useful for early diagnosis and treatment.

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  • (PMID = 21686374.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3029526
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86. Jiang L, Marlow LA, Cooper SJ, Roemeling CV, Menke DM, Copland JA, Tun HW: Selective central nervous system tropism of primary central nervous system lymphoma. Int J Clin Exp Pathol; 2010;3(8):763-7
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  • [Title] Selective central nervous system tropism of primary central nervous system lymphoma.
  • Primary Central nervous system lymphoma (PCNSL) is most frequently a diffuse large B cell lymphoma (DLBCL), which is confined to the Central nervous system (CNS).
  • We performed an experiment in which lymphoma cells from a PCNSL patient were implanted subcutaneously in an athymic mouse.
  • The lymphoma cells were shown to home to the CNS with histologic evaluations of the brain showing multiple large B cells in blood vessels consistent with intravascular large B cell lymphoma (IVL).
  • We did not find any evidence of lymphoma at the site of implantation or other locations.
  • [MeSH-major] Brain Neoplasms / pathology. Central Nervous System Neoplasms / pathology. Lymphoma, Large B-Cell, Diffuse / pathology
  • [MeSH-minor] Adult. Animals. Biomarkers, Tumor / metabolism. Brain / blood supply. Brain / pathology. Cell Movement. Fatal Outcome. Female. Humans. Lymphocytes / pathology. Mice. Mice, Nude. Neoplasm Invasiveness. Neoplasm Transplantation. Osteopontin / metabolism. Transplantation, Heterologous

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  • (PMID = 21151389.001).
  • [ISSN] 1936-2625
  • [Journal-full-title] International journal of clinical and experimental pathology
  • [ISO-abbreviation] Int J Clin Exp Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 106441-73-0 / Osteopontin
  • [Other-IDs] NLM/ PMC2993226
  • [Keywords] NOTNLM ; Lymphoma / central nervous system / tropism
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87. van Paassen J, Jonkers GJ: [Intravascular lymphoma: a rare but curable cause of interstitial lung disease]. Ned Tijdschr Geneeskd; 2005 May 14;149(20):1118-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Intravascular lymphoma: a rare but curable cause of interstitial lung disease].
  • [Transliterated title] Het intravasculair lymfoom; een zeldzame, maar curabele oorzaak van interstitiële longafwijkingen.
  • A 69-year-old man presented with dyspnoea, cough and diffuse interstitial changes and ground-glass effect on a CT-scan.
  • After 5 months the patient was diagnosed with pulmonary intravascular lymphomatosis.
  • A histologic diagnosis was made by a video-assisted thoracoscopic surgical biopsy.
  • Intravascular lymphomatosis is a rare but curable cause of interstitial lung disease.
  • Intravascular lymphomatosis is an uncommon type of non-Hodgkin's lymphoma, characterized by proliferation of neoplastic lymphoid cells within the lumen of small blood vessels, resulting in thrombotic and ischaemic complications in multiple organ systems.
  • It is important to consider intravascular lymphomatosis in the differential diagnosis of unexplained interstitial lung disease, since early diagnosis and treatment may lead to complete remission and long-term survival.
  • [MeSH-major] Lung Diseases, Interstitial / diagnosis. Lung Neoplasms / diagnosis. Lymphoma, Non-Hodgkin / diagnosis
  • [MeSH-minor] Aged. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biopsy. Diagnosis, Differential. Disease-Free Survival. Humans. Lung / pathology. Male. Thoracoscopy


88. Saleh Z, Kurban M, Ghosn S, Awar G, Kibbi AG: Generalized telangiectasia: a manifestation of intravascular B-cell lymphoma. Dermatology; 2008;217(4):318-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Generalized telangiectasia: a manifestation of intravascular B-cell lymphoma.
  • [MeSH-major] Lymphoma, B-Cell / complications. Lymphoma, B-Cell / diagnosis. Telangiectasis / etiology. Vascular Neoplasms / complications. Vascular Neoplasms / diagnosis

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  • (PMID = 18714160.001).
  • [ISSN] 1421-9832
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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89. Yoo J, Kuppachi S, Chander P: Quiz page. Large B-cell lymphoma, intravascular type, with diffuse glomerular and focal interstitial infiltration. Am J Kidney Dis; 2008 Jun;51(6):A43-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Quiz page. Large B-cell lymphoma, intravascular type, with diffuse glomerular and focal interstitial infiltration.
  • [MeSH-major] Lymphoma, Large B-Cell, Diffuse / pathology

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  • (PMID = 18501777.001).
  • [ISSN] 1523-6838
  • [Journal-full-title] American journal of kidney diseases : the official journal of the National Kidney Foundation
  • [ISO-abbreviation] Am. J. Kidney Dis.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 14
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90. Roshal M, Till BG, Fromm JR, Cherian S: Intravascular large B cell lymphoma presenting in a liver explant. J Clin Pathol; 2008 Jul;61(7):877-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intravascular large B cell lymphoma presenting in a liver explant.
  • [MeSH-major] Liver Neoplasms / pathology. Liver Transplantation. Lymphoma, Large B-Cell, Diffuse / pathology

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  • (PMID = 18587024.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
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91. Nakamichi N, Fukuhara S, Aozasa K, Morii E: NK-cell intravascular lymphomatosis--a mini-review. Eur J Haematol; 2008 Jul;81(1):1-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] NK-cell intravascular lymphomatosis--a mini-review.
  • The majority of cases of intravascular lymphomatosis (IVL) is derived from B cells.
  • The clinicopathological findings in six cases of NK-cell IVL (NK-IVL), including one new case, were summarised and compared with B-cell IVL (B-IVL) and T-cell IVL (T-IVL).
  • In summary, IVL of the B-, T- and NK-cell phenotypes is clinicopathologically distinct and shows similarities to their more common counterparts, i.e. diffuse large B-cell lymphoma, peripheral T-cell lymphoma, unspecified and extranodal NK/T-cell lymphoma, nasal type.
  • [MeSH-major] Killer Cells, Natural / pathology. Lymphoma, Non-Hodgkin / pathology. Vascular Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Antineoplastic Agents / therapeutic use. Female. Humans. Lymphoma, B-Cell. Lymphoma, T-Cell. Male. Middle Aged. Treatment Outcome

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  • (PMID = 18462254.001).
  • [ISSN] 1600-0609
  • [Journal-full-title] European journal of haematology
  • [ISO-abbreviation] Eur. J. Haematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 50
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92. Le EN, Gerstenblith MR, Gelber AC, Manno RL, Ranasinghe PD, Sweren RJ, McGirt LY: The use of blind skin biopsy in the diagnosis of intravascular B-cell lymphoma. J Am Acad Dermatol; 2008 Jul;59(1):148-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The use of blind skin biopsy in the diagnosis of intravascular B-cell lymphoma.
  • Intravascular B-cell lymphoma is a rare type of non-Hodgkin's lymphoma that is characterized by a clonal proliferation of lymphoblasts within small blood vessels.
  • Patients present with nonspecific symptoms and are often only given a diagnosis at autopsy.
  • We report a case of intravascular B-cell lymphoma, characterized by pyrexia, anemia, thrombocytopenia, and mental status decline, without obvious cutaneous manifestations, that was diagnosed with blind skin biopsy.
  • [MeSH-major] Lymphoma, B-Cell / pathology. Skin / pathology. Vascular Neoplasms / pathology


93. Feldmann R, Schierl M, Sittenthaler M, Jahn R, Wogritsch C, Cerroni L, Steiner A, Breier F: Intravascular large B-cell lymphoma of the skin: typical clinical manifestations and a favourable response to rituximab-containing therapy. Dermatology; 2009;219(4):344-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intravascular large B-cell lymphoma of the skin: typical clinical manifestations and a favourable response to rituximab-containing therapy.
  • Intravascular large B-cell lymphoma (IVBCL) is a rare malignant neoplasm characterized by the proliferation of large B cells within the blood vessels.
  • [MeSH-major] Antibodies, Monoclonal / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Lymphoma, Large B-Cell, Diffuse / drug therapy. Lymphoma, Large B-Cell, Diffuse / pathology. Skin Neoplasms / drug therapy. Skin Neoplasms / pathology. Vascular Neoplasms / drug therapy. Vascular Neoplasms / pathology

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  • [Copyright] Copyright 2009 S. Karger AG, Basel.
  • (PMID = 19590171.001).
  • [ISSN] 1421-9832
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 4F4X42SYQ6 / Rituximab; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; 9PHQ9Y1OLM / Prednisolone
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94. Morimoto K, Ogihara T, Shiomi T, Awaya N: Intravascular large B-cell lymphoma with preceding syndrome of inappropriate secretion of antidiuretic hormone. Intern Med; 2007;46(18):1569-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intravascular large B-cell lymphoma with preceding syndrome of inappropriate secretion of antidiuretic hormone.
  • Intravascular large B-cell lymphoma (IVL) is a rare subtype of B-cell lymphoma presenting with neurological and dermatological lesions in addition to generalized symptoms such as fever and malaise.
  • [MeSH-major] Inappropriate ADH Syndrome / pathology. Lymphoma, B-Cell / pathology. Lymphoma, Large B-Cell, Diffuse / pathology

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  • (PMID = 17878644.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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95. Sajid RM, Qureshi A: Involvement of bone marrow with intravascular large B-cell lymphoma. Hematol Oncol Stem Cell Ther; 2010;3(1):39-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Involvement of bone marrow with intravascular large B-cell lymphoma.
  • Intravascular large B-cell lymphoma (IVLBCL) is a rare subtype of extranodal large B-cell lymphoma characterized by a selective proliferation of lymphoma cells within the lumina of vessels.
  • The diagnosis of IVLBCL was confirmed on a bone trephine biopsy that revealed positivity of CD20 and PAX5 immunohistochemical staining of lymphoma cells confined within the lumina of vessels.
  • [MeSH-major] Bone Marrow / pathology. Lymphoma, Large B-Cell, Diffuse / pathology. Vascular Neoplasms / pathology
  • [MeSH-minor] Aged, 80 and over. Antigens, CD20 / analysis. B-Cell-Specific Activator Protein / analysis. Fatal Outcome. Humans. Male

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  • (PMID = 20231812.001).
  • [ISSN] 1658-3876
  • [Journal-full-title] Hematology/oncology and stem cell therapy
  • [ISO-abbreviation] Hematol Oncol Stem Cell Ther
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Saudi Arabia
  • [Chemical-registry-number] 0 / Antigens, CD20; 0 / B-Cell-Specific Activator Protein; 0 / PAX5 protein, human
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96. Ishii W, Ito S, Kondo Y, Tsuboi H, Mamura M, Goto D, Matsumoto I, Tsutsumi A, Sumida T, Okoshi Y, Hasegawa Y, Kojima H, Sakashita S, Aita K, Noguchi M: Intravascular large B-cell lymphoma with acute abdomen as a presenting symptom in a patient with systemic lupus erythematosus. J Clin Oncol; 2008 Mar 20;26(9):1553-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intravascular large B-cell lymphoma with acute abdomen as a presenting symptom in a patient with systemic lupus erythematosus.
  • [MeSH-major] Abdomen, Acute / etiology. Intestine, Small / pathology. Lupus Erythematosus, Systemic / complications. Lymphoma, Large B-Cell, Diffuse / complications. Lymphoma, Large B-Cell, Diffuse / diagnosis. Mesenteric Veins / pathology. Thrombosis / complications

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  • (PMID = 18349407.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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97. Kotake T, Kosugi S, Takimoto T, Nakata S, Shiga J, Nagate Y, Nakagawa T, Take H, Katagiri S: Intravascular large B-cell lymphoma presenting pulmonary arterial hypertension as an initial manifestation. Intern Med; 2010;49(1):51-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intravascular large B-cell lymphoma presenting pulmonary arterial hypertension as an initial manifestation.
  • We report a 39-year-old man with intravascular large B-cell lymphoma (IVLBCL) who had been treated as a case with pulmonary arterial hypertension (PAH) for one year.
  • After he became worse, diffuse pulmonary (18)F-fluorodeoxyglucose (FDG) uptake in positron emission tomography (PET) suggested the existence of IVLBCL in the lung showing normal CT images.
  • The diagnosis was confirmed with random transbronchial lung biopsy, and he was then successfully treated.
  • Since IVLBCL presenting PAH has been rare and is difficult to diagnose, early application of FDG-PET may provide early recognition of the disorder, leading to a better outcome.
  • [MeSH-major] Hypertension, Pulmonary / etiology. Lung Neoplasms / pathology. Lymphoma, Large B-Cell, Diffuse / complications. Lymphoma, Large B-Cell, Diffuse / pathology. Splenic Neoplasms / pathology


98. Takahashi R, Nishikawa M, Nomi F, Kusano N, Kakemizu N, Ishigatsubo Y: [Case of intravascular lymphoma diagnosed by transbronchial lung biopsy, with transient spontaneous remission]. Nihon Kokyuki Gakkai Zasshi; 2010 Nov;48(11):825-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Case of intravascular lymphoma diagnosed by transbronchial lung biopsy, with transient spontaneous remission].
  • Although malignant lymphoma was suspected, his symptoms and laboratory findings resolved spontaneously.
  • A chest radiograph showed no abnormal findings, but chest and abdominal CT images revealed diffuse ground-glass opacities in both lung fields, and splenomegaly.
  • Transbronchial lung biopsy (TBLB) confirmed a diagnosis of intravascular large B-cell lymphoma.
  • Spontaneous remission is rare in aggressive lymphomas, including intravascular lymphomas (IVL).
  • We report a case of IVL, with symptoms which resolved spontaneously, and reoccurred 19 months later with diffuse interstitial shadows on chest CT images, and in which a diagnosis of IVL was confirmed by TBLB.
  • [MeSH-major] Biopsy / methods. Lung / pathology. Lymphoma, Large B-Cell, Diffuse / diagnosis. Remission, Spontaneous. Vascular Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Male. Neoplasm Recurrence, Local

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  • (PMID = 21141061.001).
  • [ISSN] 1343-3490
  • [Journal-full-title] Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
  • [ISO-abbreviation] Nihon Kokyuki Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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99. Nakamura S, Murase T, Kinoshita T: Intravascular large B-cell lymphoma: the heterogeneous clinical manifestations of its classical and hemophagocytosis-related forms. Haematologica; 2007 Apr;92(4):434-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intravascular large B-cell lymphoma: the heterogeneous clinical manifestations of its classical and hemophagocytosis-related forms.
  • [MeSH-major] Lymphohistiocytosis, Hemophagocytic / etiology. Lymphoma, Large B-Cell, Diffuse / pathology. Vascular Neoplasms / pathology

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  • [CommentOn] Haematologica. 2007 Apr;92(4):486-92 [17488659.001]
  • (PMID = 17488652.001).
  • [ISSN] 1592-8721
  • [Journal-full-title] Haematologica
  • [ISO-abbreviation] Haematologica
  • [Language] eng
  • [Publication-type] Comment; Editorial
  • [Publication-country] Italy
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100. Anda T, Haraguchi W, Miyazato H, Tanaka S, Ishihara T, Aozasa K, Nakamichi I: Ruptured distal middle cerebral artery aneurysm filled with tumor cells in a patient with intravascular large B-cell lymphoma. J Neurosurg; 2008 Sep;109(3):492-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ruptured distal middle cerebral artery aneurysm filled with tumor cells in a patient with intravascular large B-cell lymphoma.
  • The authors describe a very rare case of intravascular large B-cell lymphoma in a woman whose ruptured distal middle cerebral artery (MCA) aneurysms were filled with lymphoma cells.
  • Based on the histological examination of the resected aneurysms, proliferation of large B-cell lymphoma was identified in the dilated arterial lumen.
  • Postmortem examination revealed similar lymphoma cells only in the intimal layer that had grown on the artificial graft, and it was decided that the patient had had intravascular large B-cell lymphoma.
  • For patients with incomprehensible ischemic cerebral stroke, neoplasm must be taken in consideration.
  • [MeSH-major] Aneurysm, Ruptured / pathology. Intracranial Aneurysm / pathology. Lymphoma, Large B-Cell, Diffuse / pathology

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  • (PMID = 18759582.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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