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1. Neves N, Lima-Rodrigues F, Ribeiro-Silva M, Cacho-Rodrigues P, Eloy C, Paiva ME, Pinto R: Epithelioid hemangioendothelioma presenting as a vertebral fracture. Acta Reumatol Port; 2010 Jul-Sep;35(3):370-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epithelioid hemangioendothelioma presenting as a vertebral fracture.
  • Epithelioid hemagioendothelioma (EH) is a rare vascular tumor with an intermediate biological behavior between hemangioma and angiosarcoma.
  • Anatomopathological study revealed an epithelioid vascular neoplasm with low mitotic index, and tumor cells reactive to vimentin, CD31 and CD34, leading to the diagnosis of Grade I Epithelioid Hemangioendothelioma.
  • [MeSH-major] Hemangioendothelioma, Epithelioid / complications. Lumbar Vertebrae / injuries. Spinal Fractures / etiology

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  • (PMID = 20975643.001).
  • [ISSN] 0303-464X
  • [Journal-full-title] Acta reumatológica portuguesa
  • [ISO-abbreviation] Acta Reumatol Port
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Portugal
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2. Jassam N, Jones CM, Briscoe T, Horner JH: The hook effect: a need for constant vigilance. Ann Clin Biochem; 2006 Jul;43(Pt 4):314-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The diagnosis was delayed as a result of unrecognized 'hooking' of a very high AFP concentration in the automated immunoassay method used.
  • The falsely low result obtained was considered normal for the patient's age and supported the diagnosis of benign haemangioendothelioma.
  • Liaison between clinical and laboratory staff was critical in obtaining an accurate AFP result, proceeding to liver biopsy and establishing the definitive diagnosis of hepatoblastoma.
  • [MeSH-major] Biomarkers, Tumor. Chemistry, Clinical / methods. Hepatoblastoma / diagnosis. Liver Neoplasms / diagnosis. Neoplasms / diagnosis. alpha-Fetoproteins / biosynthesis
  • [MeSH-minor] Automation. Biopsy. Diagnosis, Differential. Female. Humans. Immunoassay. Infant. Liver / pathology

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  • [CommentIn] Ann Clin Biochem. 2006 Jul;43(Pt 4):247-8 [16824272.001]
  • (PMID = 16824284.001).
  • [ISSN] 0004-5632
  • [Journal-full-title] Annals of clinical biochemistry
  • [ISO-abbreviation] Ann. Clin. Biochem.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / alpha-Fetoproteins
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3. Kim SR, Maekawa Y, Ninomiya T, Imoto S, Matsuoka T, Ando K, Mita K, Ku K, Koterazawa T, Nakajima T, Fukuda K, Yano Y, Nakaji M, Kudo M, Kim KI, Hirai M, Hayashi Y: Multiple hypervascular liver nodules in a heavy drinker of alcohol. J Gastroenterol Hepatol; 2005 May;20(5):795-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Ultrasound-guided needle biopsy revealed no evidence of hepatocellular carcinoma, metastatic liver cancer, hemangioendothelioma, inflammatory pseudotumors or pseudolymphoma, but demonstrated stellate-scar fibrosis septa, which contained small unpaired arteries without hyperplasia dividing the nodule.
  • From these findings, the diagnosis of alcohol-induced fibrosis, distinctly different from focal nodular hyperplasia, was tenable.
  • [MeSH-major] Liver / blood supply. Liver Cirrhosis, Alcoholic / pathology. Liver Cirrhosis, Alcoholic / ultrasonography. Neovascularization, Pathologic / pathology. Neovascularization, Pathologic / ultrasonography

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  • (PMID = 15854001.001).
  • [ISSN] 0815-9319
  • [Journal-full-title] Journal of gastroenterology and hepatology
  • [ISO-abbreviation] J. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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4. Grossman EJ, Millis JM: Liver transplantation for non-hepatocellular carcinoma malignancy: Indications, limitations, and analysis of the current literature. Liver Transpl; 2010 Aug;16(8):930-42
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  • Hepatic epithelioid hemangioendothelioma is a rare tumor of vascular origin.
  • [MeSH-minor] Aged. Cholangiocarcinoma / therapy. Hemangioendothelioma / therapy. Hepatoblastoma / therapy. Humans. Immunosuppressive Agents / therapeutic use. Liver / pathology. Medical Oncology / methods. Middle Aged. Neoplasm Metastasis. Neuroendocrine Tumors / therapy. Sarcoma / therapy. Treatment Outcome

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  • [Copyright] (c) 2010 AASLD.
  • (PMID = 20677284.001).
  • [ISSN] 1527-6473
  • [Journal-full-title] Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
  • [ISO-abbreviation] Liver Transpl.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Immunosuppressive Agents
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5. Mehrabi A, Fonouni H, Ayoub E, Rahbari NN, Müller SA, Morath Ch, Seckinger J, Sadeghi M, Golriz M, Esmaeilzadeh M, Hillebrand N, Weitz J, Zeier M, Büchler MW, Schmidt J, Schmied BM: A single center experience of combined liver kidney transplantation. Clin Transplant; 2009 Dec;23 Suppl 21:102-14
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • This has led to the acceleration of pre-existing kidney disease because of immunosuppressive nephrotoxicity making additional kidney transplantation (KTx) inevitable.
  • The analyzed parameters include demographic data, indication for LTx and KTx, duration on the waiting list, Model for End-Stage Liver Disease (MELD) score, Child-Turcotte-Pugh (CTP) score, immunosuppressive regimen, post-transplant complications, graft and patient survival, and cause of death.
  • The indications for LTx were liver cirrhosis, hyperoxaluria type 1, polycystic liver disease, primary or secondary sclerosing cholangitis, malignant hepatic epithelioid hemangioendothelioma, cystinosis, and congenital biliary fibrosis.
  • The KTx indications were end-stage renal disease of various causes, hyperoxaluria type 1, polycystic kidney disease, and cystinosis.
  • The main indications for CLKTx were oxalosis of both organs, liver cirrhosis and chronic renal failure, polycystic liver and kidney disease, and liver cirrhosis along with hepatorenal syndrome (HRS).


6. Kim TJ, Lee YS, Song YS, Park CK, Shim SI, Kang CS, Lee KY: Infantile hemangioendothelioma with elevated serum alpha fetoprotein: report of 2 cases with immunohistochemical analysis. Hum Pathol; 2010 May;41(5):763-7
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  • [Title] Infantile hemangioendothelioma with elevated serum alpha fetoprotein: report of 2 cases with immunohistochemical analysis.
  • Infantile hemangioendothelioma is the most common benign mesenchymal tumor of the liver presenting during the first 6 months of life.
  • However, it is rarely elevated in patients with hepatic infantile hemangioendothelioma.
  • We report 2 cases of solitary hepatic infantile hemangioendothelioma and demonstrate immunohistochemically that hepatocytes near or entrapped within the tumor were the source of the increased serum levels of alpha fetoprotein explaining the unusual clinical presentation.
  • [MeSH-major] Hemangioendothelioma / metabolism. Liver / metabolism. Liver Neoplasms / metabolism. alpha-Fetoproteins / metabolism

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  • [Copyright] Crown Copyright 2010. Published by Elsevier Inc. All rights reserved.
  • [CommentIn] Hum Pathol. 2011 Sep;42(9):1369-71; author reply 1371-2 [21839297.001]
  • (PMID = 20153513.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / alpha-Fetoproteins
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7. Kalpatthi R, Germak J, Mizelle K, Yeager N: Thyroid abnormalities in infantile hepatic hemangioendothelioma. Pediatr Blood Cancer; 2007 Dec;49(7):1021-4
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  • [Title] Thyroid abnormalities in infantile hepatic hemangioendothelioma.
  • We report an infant with hepatic hemangioendothelioma (HAE) associated with compensated hypothyroidism.
  • [MeSH-major] Hemangioendothelioma / complications. Hypothyroidism / complications. Liver Neoplasms / complications. Thyroxine / therapeutic use

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  • [Copyright] 2007 Wiley-Liss, Inc
  • (PMID = 16544297.001).
  • [ISSN] 1545-5009
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Steroids; Q51BO43MG4 / Thyroxine
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8. Liu XJ, Tai MZ, Tian MX, Qin ZP: [Clinical analysis of 17 cases of pneumatic compression therapy in infants with Kasabach-Merritt phenomenon]. Zhonghua Yi Xue Za Zhi; 2009 Jul 14;89(26):1830-3
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  • RESULTS: Two patients were cured after pneumatic compression therapy for 4 and 6 months respectively, and their lesions disappeared, blood parameters became normal and remained relapse-free after a 5/11-year follow-up.
  • There were 14 cases of kaposiform hemangioendothelioma (KHE) and 3 cases of tufted hemangioma (TA).
  • [MeSH-major] Anemia, Hemolytic / therapy. Hemangioendothelioma / therapy. Physical Therapy Modalities. Thrombocytopenia / therapy

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  • (PMID = 19953927.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] China
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9. Iwami D, Shimaoka S, Mochizuki I, Sakuma T: Kaposiform hemangioendothelioma of the mediastinum in a 7-month-old boy: a case report. J Pediatr Surg; 2006 Aug;41(8):1486-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Kaposiform hemangioendothelioma of the mediastinum in a 7-month-old boy: a case report.
  • Kaposiform hemangioendothelioma is an aggressive vascular proliferation that has been recognized as a separate entity from other childhood vascular tumors.
  • The authors present an unusual case of hemangioendothelioma arising in the mediastinum of a 7-month-old male infant with acute respiratory distress and Kasabach-Merritt syndrome.
  • This case had many histologic and clinical features consistent with kaposiform hemangioendothelioma.
  • [MeSH-major] Hemangioendothelioma / drug therapy. Mediastinal Neoplasms / drug therapy

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  • (PMID = 16863862.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Interferon-alpha; 0 / Recombinant Proteins; 76543-88-9 / interferon alfa-2a
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10. Galambos C, Nodit L: Identification of lymphatic endothelium in pediatric vascular tumors and malformations. Pediatr Dev Pathol; 2005 Mar-Apr;8(2):181-9
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  • [Title] Identification of lymphatic endothelium in pediatric vascular tumors and malformations.
  • The distinction between lymphatic and other vascular vessels on microscopic sections is a challenging task.
  • We studied the specificity and sensitivity of D2-40 in pediatric vascular tumors and malformations.
  • Fourteen lymphatic and 11 vascular lesions were randomly selected and stained with D2-40 and CD31 antibodies.
  • The lymphatic lesions included 6 lymphatic malformations, 5 cystic hygromas (macrocystic lymphatic malformation), 2 lymphovenous malformations, and 1 lymphangioma, and the vascular lesions comprised 3 infantile hemangiomas, 3 Kaposiform hemangioendotheliomas, 2 tufted angiomas, 1 pyogenic granuloma, 1 arteriovenous, and 1 venulocapillary malformations.
  • The staining patterns of the vascular channels were compared.
  • In all lesions D2-40 labeled only the endothelium of thin-walled vascular channels morphologically consistent with lymphatic vessels (25 of 25).
  • No staining of the vascular lesions (0 of 11) or of arteries and veins (0 of 25) was observed.
  • CD31 constantly labeled arteries, veins, capillaries, and lymphatics in all lesions and all endothelial cells in the vascular lesions.
  • Currently, D2-40 appears to be a good marker to identify lymphatic vessels in pediatric vascular tumors and malformations.
  • [MeSH-major] Antibodies, Monoclonal. Endothelium, Lymphatic / pathology. Lymphatic Vessel Tumors / pathology. Lymphatic Vessels / abnormalities. Soft Tissue Neoplasms / pathology

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  • (PMID = 15719202.001).
  • [ISSN] 1093-5266
  • [Journal-full-title] Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
  • [ISO-abbreviation] Pediatr. Dev. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Biomarkers
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11. White JB, Pullman J, Wenig B, Smith RV: Kaposiform hemangioendothelioma of the tongue in an adult. Arch Otolaryngol Head Neck Surg; 2009 Aug;135(8):824-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Kaposiform hemangioendothelioma of the tongue in an adult.
  • [MeSH-major] Hemangioendothelioma / diagnosis. Sarcoma, Kaposi / diagnosis. Tongue Neoplasms / diagnosis
  • [MeSH-minor] Biopsy. Diagnosis, Differential. Humans. Male. Young Adult


12. Aalaei S, Jakate S: Right upper quadrant pain and fever in a 41-year-old man. Epithelioid hemangioendothelioma of the liver with metastasis to porta hepatis lymph nodes and lung. Arch Pathol Lab Med; 2005 May;129(5):e134-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Right upper quadrant pain and fever in a 41-year-old man. Epithelioid hemangioendothelioma of the liver with metastasis to porta hepatis lymph nodes and lung.
  • [MeSH-major] Hemangioendothelioma, Epithelioid / secondary. Liver Neoplasms / pathology. Lung Neoplasms / secondary. Lymph Nodes / pathology

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  • (PMID = 15859662.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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13. Lutgendorf MA, Magann EF, Yousef M, Hill JB, Foster DT: Hepatic epithelial hemangioendothelioma in pregnancy. Gynecol Obstet Invest; 2009;67(4):238-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hepatic epithelial hemangioendothelioma in pregnancy.
  • BACKGROUND: Epithelioid hemangioendothelioma (EHE) is a rare vascular neoplasm that affects various tissues including liver, lung, gastrointestinal tract, head and neck, bone, heart and the central nervous system.
  • [MeSH-major] Hemangioendothelioma, Epithelioid / complications. Liver Neoplasms / complications. Pregnancy Complications, Neoplastic / diagnosis
  • [MeSH-minor] Adult. Appendectomy. Appendicitis / complications. Appendicitis / diagnosis. Appendicitis / surgery. Biopsy, Fine-Needle. Female. Gestational Age. Humans. Liver / pathology. Lung Neoplasms / complications. Lung Neoplasms / diagnosis. Magnetic Resonance Imaging. Pregnancy. Tomography, X-Ray Computed


14. Karnes JC, Lee BT, Phung T, Alomari AI, Mulliken JB, Greene AK: Adult-onset kaposiform hemangioendothelioma in a posttraumatic site. Ann Plast Surg; 2009 Apr;62(4):456-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adult-onset kaposiform hemangioendothelioma in a posttraumatic site.
  • [MeSH-major] Hemangioendothelioma / surgery


15. Warren AL, Summers BA: Epithelioid variant of hemangioma and hemangiosarcoma in the dog, horse, and cow. Vet Pathol; 2007 Jan;44(1):15-24
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Epithelioid hemangiomas, hemangioendotheliomas, and angiosarcomas are well recognized histologic variants of endothelial tumors in humans that in the past have been confused with neoplasms of epithelial or histiocytic origin.
  • We describe 12 epithelioid endothelial vascular tumors in 8 dogs, 3 horses, and 1 cow that share microscopic features with these tumors in humans.
  • We subdivided these tumors into epithelioid hemangiomas (n = 3) and hemangiosarcomas (n = 9) based on conventional morphologic criteria, growth pattern (invasive or not), and metastasis (known in 1 case at the time of biopsy).
  • This series represents a novel group of vascular tumors in domestic animals of which there are only 3 previous cases reported in the veterinary literature.

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  • (PMID = 17197620.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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16. Bölke E, Gripp S, Peiper M, Budach W, Schwarz A, Orth K, Reinecke P, van de Nes JA: Multifocal epithelioid hemangioendothelioma: case report of a clinical chamaeleon. Eur J Med Res; 2006 Nov 30;11(11):462-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multifocal epithelioid hemangioendothelioma: case report of a clinical chamaeleon.
  • Epithelioid hemangioendothelioma is an extremely rare vascular bone tumor with a slow growth and poor prognosis.
  • Various synonyms for epithelioid hemangioendothelioma are used clinically: low grade anaplastic angiosarcoma, cellular hemangioma, histiocytoid hemangioma and angioendothelioma.
  • However, it represents 1% of all vascular neoplasms and is locally aggressive.
  • We report the course of disease of a 47-year-old man who presented to our clinic with unspecific abdominal and back pain.
  • Tumor histology of the bone and liver biopsies confirmed the diagnosis of epithelioid hemangioendothelioma.
  • Although treatment was initiated with thalidomide, the patient developed multiple organ dysfunction syndrome (MODS) and succumbed to his disease.
  • [MeSH-major] Hemangioendothelioma, Epithelioid / pathology. Liver Neoplasms / pathology. Spinal Neoplasms / pathology. Splenic Neoplasms / pathology
  • [MeSH-minor] Angiogenesis Inhibitors / therapeutic use. Diagnosis, Differential. Fatal Outcome. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Syndrome. Thalidomide / therapeutic use. Tomography, X-Ray Computed

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  • (PMID = 17182357.001).
  • [ISSN] 0949-2321
  • [Journal-full-title] European journal of medical research
  • [ISO-abbreviation] Eur. J. Med. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 4Z8R6ORS6L / Thalidomide
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17. Sevinir B, Ozkan TB: Infantile hepatic hemangioendothelioma: clinical presentation and treatment. Turk J Gastroenterol; 2007 Sep;18(3):182-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Infantile hepatic hemangioendothelioma: clinical presentation and treatment.
  • BACKGROUND/AIMS: Hepatic hemangioendotheliomas are rare tumors in childhood.
  • METHODS: This retrospective analysis included eight patients with infantile hepatic hemangioendothelioma.
  • RESULTS: The median age at diagnosis was 24 days (age range: 1 to 70 days) and the female/male ratio was 5/3.
  • [MeSH-major] Hemangioendothelioma / diagnosis. Hemangioendothelioma / therapy. Liver Neoplasms / diagnosis. Liver Neoplasms / therapy
  • [MeSH-minor] Abdomen. Alanine Transaminase / metabolism. Aspartate Aminotransferases / metabolism. Dilatation, Pathologic / etiology. Female. Glucocorticoids / therapeutic use. Hemangioma / diagnosis. Hepatomegaly / etiology. Humans. Immunologic Factors / therapeutic use. Infant. Infant, Newborn. Interferon-alpha / therapeutic use. Male. Neoplasms, Multiple Primary. Prednisolone / therapeutic use. Respiratory Distress Syndrome, Newborn / etiology. Retrospective Studies. Skin Neoplasms / diagnosis. Turkey / epidemiology

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  • (PMID = 17891692.001).
  • [ISSN] 2148-5607
  • [Journal-full-title] The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
  • [ISO-abbreviation] Turk J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Turkey
  • [Chemical-registry-number] 0 / Glucocorticoids; 0 / Immunologic Factors; 0 / Interferon-alpha; 9PHQ9Y1OLM / Prednisolone; EC 2.6.1.1 / Aspartate Aminotransferases; EC 2.6.1.2 / Alanine Transaminase
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18. Hartman KR, Moncur JT, Minniti CP, Creamer KM: Mediastinal Kaposiform hemangioendothelioma and Kasabach-Merritt phenomenon in an infant: treatment with interferon. J Pediatr Hematol Oncol; 2009 Sep;31(9):690-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mediastinal Kaposiform hemangioendothelioma and Kasabach-Merritt phenomenon in an infant: treatment with interferon.
  • A 2-week-old infant developed respiratory failure due to a mediastinal Kaposiform hemangioendothelioma that was complicated by thrombocytopenia and consumptive coagulopathy.
  • Multiple transfusions with fresh frozen plasma, platelets, and red blood cells were needed for the consumptive coagulopathy, and ventilatory support was required for 5 months.
  • This case demonstrates that interferon can be used to treat infants with Kaposiform hemangioendothelioma in life-threatening situations that do not respond to other forms of treatment.
  • [MeSH-major] Anemia, Hemolytic / etiology. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Disseminated Intravascular Coagulation / etiology. Hemangioendothelioma / complications. Interferon-alpha / therapeutic use. Mediastinal Neoplasms / complications. Respiratory Insufficiency / etiology. Thrombocytopenia / etiology
  • [MeSH-minor] Aminocaproates / administration & dosage. Blood Component Transfusion. Combined Modality Therapy. Female. Humans. Infant, Newborn. Methylprednisolone / administration & dosage. Plasma. Respiration, Artificial. Syndrome. Thoracotomy. Thymectomy. Vincristine / administration & dosage


19. Patnayak R, Jena A, Reddy MK, Chowhan AK, Rao LC, Rukhamangadha N: Epithelioid hemangioendothelioma of nasal cavity. J Lab Physicians; 2010 Jul;2(2):111-3
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  • [Title] Epithelioid hemangioendothelioma of nasal cavity.
  • We present a rare case of epithelioid hemangioendothelioma (EHE) in the nasal cavity of a 40-year-old Indian male who presented with history of intermittent epistaxis.
  • The lesion was tested for a panel of immunohistochemical markers like vimentin, CD31, CD34, Factor VIII, vascular endothelial growth factor (VEGF) and Ki67.
  • Immunohistochemically, the neoplasm showed striking positivity for vimentin, CD31, CD34 and weak positivity for VEGF; positivity was also noted for Factor VIII especially in the miniature intracytoplasmic vascular lumina.

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  • [Cites] Semin Diagn Pathol. 1986 Nov;3(4):259-87 [3303234.001]
  • [Cites] J Chin Med Assoc. 2005 Jan;68(1):45-8 [15742864.001]
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  • (PMID = 21346909.001).
  • [ISSN] 0974-7826
  • [Journal-full-title] Journal of laboratory physicians
  • [ISO-abbreviation] J Lab Physicians
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3040087
  • [Keywords] NOTNLM ; Epithelioid hemangioendothelioma / immunohistochemistry / nasal cavity
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20. Edwards JR, Williams K, Kindblom LG, Meis-Kindblom JM, Hogendoorn PC, Hughes D, Forsyth RG, Jackson D, Athanasou NA: Lymphatics and bone. Hum Pathol; 2008 Jan;39(1):49-55
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  • In normal bone, LYVE-1+/podoplanin+ lymphatic vessels were not identified in cortical or cancellous bone but were seen in connective tissue overlying the periosteum.
  • With the exception of lymphangioma, Gorham-Stout disease, and hemangioendothelioma, primary benign and malignant bone tumors (as well as secondary carcinomas) that were confined to bone did not contain lymphatic vessels.
  • Primary and secondary bone tumors that had extended through the bone cortex contained LYVE-1+/podoplanin+ lymphatic vessels that seemed to extend for a short distance from surrounding soft tissues into the tumor.
  • These findings also suggest that lymphangiogenesis is not involved in the disease progression of most primary bone tumors and that carcinomatous metastasis to bone does not occur via lymphatics.

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  • [CommentIn] Hum Pathol. 2009 Jan;40(1):143-4; author reply 144 [19027456.001]
  • (PMID = 17904616.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / MC/ U137884182
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / LYVE1 protein, human; 0 / Membrane Glycoproteins; 0 / PDPN protein, human; 0 / Vesicular Transport Proteins
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21. Mucha K, Foroncewicz B, Zieniewicz K, Nyckowski P, Krawczyk M, Cyganek A, Paczek L: Patient with liver epithelioid hemangioendothelioma treated by transplantation: 3 years' observation. Transplant Proc; 2006 Jan-Feb;38(1):231-3
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  • [Title] Patient with liver epithelioid hemangioendothelioma treated by transplantation: 3 years' observation.
  • Epithelioid hemangioendothelioma (EHE) is a rare neoplasm of vascular origin, but unknown etiology that occurs in the liver, lungs and other organs.
  • Surgical resection or liver transplantation (OLT) has been recommended after diagnosis.
  • The histopathological diagnosis from a needle biopsy was carcinoma cholangiogenes desmoplasticum.
  • We concluded that immunohistochemical staining for characteristic endothelial cell markers may facilitate the correct diagnosis of HEHE.
  • After diagnosis, OLT followed by immunosuppressive therapy, consisting of basiliximab, corticoids, low doses of tacrolimus and temporary administration of rapamycin, may be safe and effective.
  • [MeSH-major] Hemangioendothelioma, Epithelioid / surgery. Liver Neoplasms / surgery. Liver Transplantation / methods


22. Ergün EL, Lim E: Increased FDG uptake in pulmonary epitheloid hemangioendothelioma. Rev Esp Med Nucl; 2006 May-Jun;25(3):188-92
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  • [Title] Increased FDG uptake in pulmonary epitheloid hemangioendothelioma.
  • The histological findings and immunohistochemistry tests were consistent with pulmonary epitheloid hemangioendothelioma (PEH).
  • Epitheloid hemangioendothelioma (EH) is a systemic name that represents a rare type of malignant tumor of vascular endothelial origin, which can arise in bone, liver, soft-tissue, or lung.
  • [MeSH-major] Fluorine Radioisotopes. Fluorodeoxyglucose F18. Hemangioendothelioma, Epithelioid / radionuclide imaging. Lung Neoplasms / radionuclide imaging. Neoplasms, Multiple Primary / radionuclide imaging. Positron-Emission Tomography. Radiopharmaceuticals

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  • (PMID = 16762274.001).
  • [ISSN] 0212-6982
  • [Journal-full-title] Revista española de medicina nuclear
  • [ISO-abbreviation] Rev Esp Med Nucl
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Fluorine Radioisotopes; 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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23. Yu RS, Chen Y, Jiang B, Wang LH, Xu XF: Primary hepatic sarcomas: CT findings. Eur Radiol; 2008 Oct;18(10):2196-205
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  • Different primary hepatic sarcomas may have different clinical, morphologic, and radiological features.
  • In this pictorial review, we summarized computed tomography (CT) findings of some relatively common types of hepatic sarcomas, including angiosarcoma, epithelioid hemangioendothelioma (EHE), liposarcoma, undifferentiated embryonal sarcoma (UES), leiomyosarcoma, malignant fibrous histiocytoma (MFH), and carcinosarcoma (including cystadenocarcinosarcoma).
  • The advent of CT has allowed earlier detection of primary hepatic sarcomas as well as more accurate diagnosis and characterization.

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  • (PMID = 18463872.001).
  • [ISSN] 0938-7994
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 53
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24. Hassan I, Barth P, Celik I, Hoffmann S, Langer P, Ramaswamy A, Wagner HJ, Rothmund M, Zielke A: An authentic malignant epithelioid hemangioendothelioma of the thyroid: a case report and review of the literature. Thyroid; 2005 Dec;15(12):1377-81
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  • [Title] An authentic malignant epithelioid hemangioendothelioma of the thyroid: a case report and review of the literature.
  • Hemangioendotheliomas of the thyroid are neoplasms that are rarely encountered in the Alpine region in Europe.
  • We report the second case of an epithelioid hemangioendothelioma (EHE) of the thyroid gland and the first clinical case with malignant behavior.
  • Tumor cells were positive for factor VIII-related antigen, MNF116, PAN-ceratin, CD 34, and CD 31 and negative for cytokeratin allowing the diagnosis of EHE.
  • The patient rapidly developed a second local relapse and died 13 months after the diagnosis of an EHE had been made.
  • An improvement of the very poor prognosis of this rare tumor may depend on early tumor diagnosis and surgery combined with a multimodal treatment.
  • [MeSH-major] Hemangioendothelioma, Epithelioid / pathology. Thyroid Neoplasms / pathology

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  • (PMID = 16405412.001).
  • [ISSN] 1050-7256
  • [Journal-full-title] Thyroid : official journal of the American Thyroid Association
  • [ISO-abbreviation] Thyroid
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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25. Faik A, Allali F, El Hassani S, Hajjaj-Hassouni N: Maffucci's syndrome: a case report. Clin Rheumatol; 2006 Feb;25(1):88-91
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  • The biopsy of the third right metacarpal showed enchondroma tissue.
  • Histological examination of the skin specimen showed a hemangioendothelioma.
  • The diagnosis of Maffucci's syndrome was established.
  • [MeSH-minor] Adult. Female. Hemangioendothelioma / pathology. Humans. Radiography. Skin Neoplasms / pathology

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  • (PMID = 16234991.001).
  • [ISSN] 0770-3198
  • [Journal-full-title] Clinical rheumatology
  • [ISO-abbreviation] Clin. Rheumatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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26. Nudo CG, Yoshida EM, Bain VG, Marleau D, Wong P, Marotta PJ, Renner E, Watt KD, Deschênes M: Liver transplantation for hepatic epithelioid hemangioendothelioma: the Canadian multicentre experience. Can J Gastroenterol; 2008 Oct;22(10):821-4
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  • [Title] Liver transplantation for hepatic epithelioid hemangioendothelioma: the Canadian multicentre experience.
  • INTRODUCTION: Hepatic epithelioid hemangioendothelioma (HEHE) is a rare entity.
  • [MeSH-major] Hemangioendothelioma, Epithelioid / surgery. Liver Neoplasms / surgery. Liver Transplantation
  • [MeSH-minor] Adolescent. Adult. Canada / epidemiology. Female. Follow-Up Studies. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Recurrence, Local. Splenic Neoplasms / secondary. Survival Rate. Treatment Outcome. Young Adult


27. Sanchez-Carpintero I, Martínez MI, Mihm MC Jr: Clinical and histopathologic observations of the action of imiquimod in an epithelioid hemangioendothelioma and Paget's mammary disease. J Am Acad Dermatol; 2006 Jul;55(1):75-9
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  • [Title] Clinical and histopathologic observations of the action of imiquimod in an epithelioid hemangioendothelioma and Paget's mammary disease.
  • An epithelioid hemangioendothelioma and Paget's disease of the breast were treated with topical imiquimod 5% cream with very impressive results.
  • In this article, in addition to describing the treatment approach, the findings in biopsy specimens of the epithelioid hemangioendothelioma and the Paget's disease before, during, and after therapy will be described.
  • Furthermore, mast cells appear to be involved in the development of regression in the vascular tumor.
  • [MeSH-major] Aminoquinolines / therapeutic use. Antineoplastic Agents / therapeutic use. Breast Neoplasms / drug therapy. Breast Neoplasms / pathology. Facial Neoplasms / drug therapy. Facial Neoplasms / pathology. Hemangioendothelioma, Epithelioid / drug therapy. Hemangioendothelioma, Epithelioid / pathology. Paget's Disease, Mammary / drug therapy. Paget's Disease, Mammary / pathology

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  • (PMID = 16781296.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Aminoquinolines; 0 / Antineoplastic Agents; 99011-02-6 / imiquimod
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28. Gupta NP, Kolla SB, Panda S, Sharma MC: Epitheloid hemangioendothelioma of urinary bladder. Indian J Urol; 2008 Apr;24(2):253-5
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  • [Title] Epitheloid hemangioendothelioma of urinary bladder.
  • Epitheloid hemangioendothelioma is an uncommon vascular neoplasm and has an unpredictable clinical behavior.
  • Most often, epitheloid hemangioendothelioma arise from the soft tissues of the upper and lower extremities and it has borderline malignant potential.
  • We describe the first reported case of epitheloid hemangioendothelioma in the urinary bladder, which was treated by transurethral resection.
  • The diagnosis was confirmed by immunohistochemistry.

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  • [Cites] Urology. 1998 Nov;52(5):778-84 [9801098.001]
  • [Cites] Am J Surg Pathol. 1997 Apr;21(4):363-74 [9130982.001]
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  • (PMID = 19468406.001).
  • [ISSN] 0970-1591
  • [Journal-full-title] Indian journal of urology : IJU : journal of the Urological Society of India
  • [ISO-abbreviation] Indian J Urol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2684281
  • [Keywords] NOTNLM ; Hemangioendothelioma / urinary bladder
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29. Velázquez CJ, Font JI, Torres F, Araji O, Barquero JM: Masson tumor as humeral artery aneurysm. Ann Vasc Surg; 2008 Jan;22(1):127-9
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  • Intravascular papillary endothelial hyperplasia (Masson's vegetant hemangioendothelioma) is a rare condition affecting the arteries.
  • We present a case of asymptomatic humeral artery vascular tumor due to this abnormality.
  • The tumor was removed, and the vascular segment was replaced by a segment of inverted cephalic vein.
  • This rare vascular lesion may be clinically and histopathologically mistaken for a malignant tumor.
  • As the Masson tumor can be cured by complete surgical resection, it is important to get a correct diagnosis.
  • [MeSH-major] Aneurysm / complications. Arm / blood supply. Endothelium, Vascular / pathology. Hemangioendothelioma / diagnosis. Vascular Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Hyperplasia. Middle Aged. Treatment Outcome. Vascular Surgical Procedures

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  • (PMID = 18083332.001).
  • [ISSN] 0890-5096
  • [Journal-full-title] Annals of vascular surgery
  • [ISO-abbreviation] Ann Vasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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30. Tejera-Vaquerizo A, Herrera-Ceballos E, Bosch-García R, Fernandez-Orland A, Matilla A: Composite cutaneous hemangioendothelioma on the back. Am J Dermatopathol; 2008 Jun;30(3):262-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Composite cutaneous hemangioendothelioma on the back.
  • Composite cutaneous hemangioendothelioma (HE) is the most recently described variant of the lesions known as HEs.
  • This neoplasm is considered to be of borderline or low-grade malignancy, because despite its frequency it rarely metastasizes.
  • [MeSH-major] Hemangioendothelioma, Epithelioid / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Antigens, CD31 / analysis. Back. Biomarkers, Tumor / analysis. Epithelioid Cells / chemistry. Epithelioid Cells / pathology. Female. Humans. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Treatment Outcome

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  • (PMID = 18496428.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Biomarkers, Tumor
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31. Sidbury R: Update on vascular tumors of infancy. Curr Opin Pediatr; 2010 Aug;22(4):432-7
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  • [Title] Update on vascular tumors of infancy.
  • PURPOSE OF REVIEW: Advances have been made in the pathogenesis, diagnosis and management of vascular tumors of infancy in the past year.
  • Kaposiform hemangioendothelioma and tufted angioma are less common than IH but more often associated with coagulopathy (Kasabach-Merritt phenomenon).
  • Segmental IH may herald underlying structural anomalies of the brain, cerebral, and cardiac vessels (PHACE syndrome--Posterior fossa defects, Hemangiomas, Arterial anomalies, Cardiac defects and Coarctation of the aorta, Eye anomalies), and new criteria aid in diagnosis.
  • A recent review of kaposiform hemangioendothelioma finds that an associated coagulopathy (Kasabach-Merritt phenomenon) occurs in 72%.
  • SUMMARY: Propranolol appears to be tremendously efficacious with fewer side effects than systemic corticosteroids, but its proper place in the therapeutic algorithm for IH and other vascular tumors awaits controlled study.
  • [MeSH-major] Endothelium, Vascular / pathology. Neoplasm Staging / methods. Propranolol / therapeutic use. Vascular Neoplasms

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  • (PMID = 20601884.001).
  • [ISSN] 1531-698X
  • [Journal-full-title] Current opinion in pediatrics
  • [ISO-abbreviation] Curr. Opin. Pediatr.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Vasodilator Agents; 9Y8NXQ24VQ / Propranolol
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32. Terui K, Nakatani Y, Kambe M, Fukunaga M, Hishiki T, Saito T, Sato Y, Takenouchi A, Saito E, Ono S, Yoshida H: Kaposiform hemangioendothelioma of the choledochus. J Pediatr Surg; 2010 Sep;45(9):1887-9
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  • [Title] Kaposiform hemangioendothelioma of the choledochus.
  • Kaposiform hemangioendothelioma (KHE) is a rare, locally aggressive vascular neoplasm that mainly occurs during childhood.
  • Contrast computed tomography revealed a vascular tumor in the hepatic portal region causing biliary obstruction.
  • [MeSH-major] Cholestasis / surgery. Common Bile Duct Neoplasms / surgery. Hemangioendothelioma / surgery. Jaundice, Obstructive / surgery

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20850638.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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33. Eckardt AM, Barth EL, Berten J, Gellrich NC: Pediatric mandibular resection and reconstruction: long-term results with autogenous rib grafts. Craniomaxillofac Trauma Reconstr; 2010 Mar;3(1):25-32
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  • Histologic diagnoses were melanotic neuroectodermal tumor (n = 2), hemangioendothelioma of the mandible (n = 1), and ameloblastoma (n = 1).

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  • (PMID = 22110815.001).
  • [ISSN] 1943-3883
  • [Journal-full-title] Craniomaxillofacial trauma & reconstruction
  • [ISO-abbreviation] Craniomaxillofac Trauma Reconstr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3052664
  • [Keywords] NOTNLM ; Mandibular reconstruction / bone graft / facial growth / pediatric maxillofacial tumor / rib graft
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34. Drucker AM, Pope E, Mahant S, Weinstein M: Vincristine and corticosteroids as first-line treatment of Kasabach-Merritt syndrome in kaposiform hemangioendothelioma. J Cutan Med Surg; 2009 May-Jun;13(3):155-9
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  • [Title] Vincristine and corticosteroids as first-line treatment of Kasabach-Merritt syndrome in kaposiform hemangioendothelioma.
  • OBJECTIVE: To report a case of a newborn with a kaposiform hemangioendothelioma (KHE) of the right leg associated with KMS treated successfully with vincristine and oral corticosteroids.
  • [MeSH-major] Antineoplastic Agents, Phytogenic / therapeutic use. Blood Coagulation Disorders / drug therapy. Glucocorticoids / therapeutic use. Hemangioendothelioma / drug therapy. Skin / pathology. Vincristine / therapeutic use. Xeroderma Pigmentosum / drug therapy
  • [MeSH-minor] Administration, Oral. Biopsy. Diagnosis, Differential. Drug Therapy, Combination. Female. Follow-Up Studies. Humans. Infant, Newborn. Syndrome


35. Kim DW, Chung JH, Ahn SH, Kwon TK: Laryngeal kaposiform hemangioendothelioma: case report and literature review. Auris Nasus Larynx; 2010 Apr;37(2):258-62
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  • [Title] Laryngeal kaposiform hemangioendothelioma: case report and literature review.
  • The kaposiform hemangioendothelioma (KHE) is an uncommon vascular neoplasm of borderline or intermediate malignant potential in which involvement of the head and neck region is rare.
  • The pathologic diagnosis of the tumor was KHE.
  • [MeSH-major] Emergencies. Hemangioendothelioma, Epithelioid / diagnosis. Hemoptysis / etiology. Laryngeal Neoplasms / diagnosis. Sarcoma, Kaposi / diagnosis

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  • [Copyright] Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 19553040.001).
  • [ISSN] 1879-1476
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 15
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36. Mehrabi A, Kashfi A, Schemmer P, Sauer P, Encke J, Fonouni H, Friess H, Weitz J, Schmidt J, Büchler MW, Kraus TW: Surgical treatment of primary hepatic epithelioid hemangioendothelioma. Transplantation; 2005 Sep 27;80(1 Suppl):S109-12
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  • [Title] Surgical treatment of primary hepatic epithelioid hemangioendothelioma.
  • Epithelioid hemangioendothelioma is a very rare tumor of vascular origin.
  • It can develop in different tissues such as soft tissue, lung, or liver.
  • Hepatic epithelioid hemangioendothelioma (HEH) mostly affects females.
  • [MeSH-major] Hemangioendothelioma, Epithelioid / surgery. Liver Neoplasms / surgery

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  • (PMID = 16286886.001).
  • [ISSN] 0041-1337
  • [Journal-full-title] Transplantation
  • [ISO-abbreviation] Transplantation
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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37. Lisle JW, Bradeen HA, Kalof AN: Kaposiform hemangioendothelioma in multiple spinal levels without skin changes. Clin Orthop Relat Res; 2009 Sep;467(9):2464-71
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  • [Title] Kaposiform hemangioendothelioma in multiple spinal levels without skin changes.
  • Kaposiform hemangioendothelioma is a rare vascular tumor of childhood that is locally aggressive but has little metastatic potential and by itself is not known to be lethal.
  • It most commonly presents as a superficial or deep soft tissue mass with associated cutaneous lesions.
  • Kasabach-Merritt phenomenon, a condition characterized by profound thrombocytopenia and life-threatening hemorrhage, often is associated with kaposiform hemangioendothelioma.
  • Six cases of kaposiform hemangioendothelioma have been reported in bone, two of which were located in extracraniofacial bones.
  • We report a diagnostically challenging case of a 6-year-old girl with kaposiform hemangioendothelioma of the thoracolumbar spine without Kasabach-Merritt phenomenon or cutaneous lesions.
  • [MeSH-major] Hemangioendothelioma / pathology. Sarcoma, Kaposi / pathology. Spinal Neoplasms / pathology

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  • (PMID = 19381744.001).
  • [ISSN] 1528-1132
  • [Journal-full-title] Clinical orthopaedics and related research
  • [ISO-abbreviation] Clin. Orthop. Relat. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Antigens, CD31; 0 / Biomarkers, Tumor; 0 / Pyrazoles; 0 / Sulfonamides; 4Z8R6ORS6L / Thalidomide; JCX84Q7J1L / Celecoxib
  • [Other-IDs] NLM/ PMC2866913
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38. Rodriguez JA, Becker NS, O'Mahony CA, Goss JA, Aloia TA: Long-term outcomes following liver transplantation for hepatic hemangioendothelioma: the UNOS experience from 1987 to 2005. J Gastrointest Surg; 2008 Jan;12(1):110-6
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  • [Title] Long-term outcomes following liver transplantation for hepatic hemangioendothelioma: the UNOS experience from 1987 to 2005.
  • INTRODUCTION: Hepatic hemangioendothelioma (HEH) is a vascular neoplasm with intermediate malignant potential.
  • METHODS: Using the United Network for Organ Sharing (UNOS) database, we identified 110 patients with a diagnosis of HEH who underwent 126 transplants between 1987 and 2005.
  • [MeSH-major] Hemangioendothelioma / surgery. Liver Neoplasms / surgery. Liver Transplantation / methods


39. Eckardt A, Swennen G, Brachvogel P: [Autologous rib graft for restoration of continuity defects of the mandible]. Mund Kiefer Gesichtschir; 2005 Mar;9(2):66-70
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  • Histological diagnoses were melanotic neuroectodermal tumor and hemangioendothelioma of the mandible.
  • [MeSH-major] Bone Transplantation / methods. Hemangioendothelioma / surgery. Mandible / surgery. Mandibular Neoplasms / surgery. Neuroectodermal Tumor, Melanotic / surgery

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  • [ISSN] 1432-9417
  • [Journal-full-title] Mund-, Kiefer- und Gesichtschirurgie : MKG
  • [ISO-abbreviation] Mund Kiefer Gesichtschir
  • [Language] ger
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40. Kajihara Y, Ikawa F, Ohbayashi N, Imada Y, Hidaka T, Matsushige T, Mitsuhara T, Inagawa T, Ohama E: [Hemangioendothelioma of the brain presenting with intracerebral hemorrhage: a case report]. No To Shinkei; 2005 Aug;57(8):690-4
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  • [Title] [Hemangioendothelioma of the brain presenting with intracerebral hemorrhage: a case report].
  • Hemangioendothelioma (HE) is an uncommon vascular tumor that is intermediate in histological appearance between a hemangioma and an angiosarcoma.
  • Intratumoral hemorrhage was indicated and preoperative diagnosis was cavernous angioma.
  • [MeSH-major] Brain Neoplasms / complications. Cerebral Hemorrhage / etiology. Hemangioendothelioma / complications

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  • (PMID = 16146213.001).
  • [ISSN] 0006-8969
  • [Journal-full-title] Nō to shinkei = Brain and nerve
  • [ISO-abbreviation] No To Shinkei
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 19
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41. Gordillo G, Fang H, Park H, Roy S: Nox-4-dependent nuclear H2O2 drives DNA oxidation resulting in 8-OHdG as urinary biomarker and hemangioendothelioma formation. Antioxid Redox Signal; 2010 Apr 15;12(8):933-43
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  • [Title] Nox-4-dependent nuclear H2O2 drives DNA oxidation resulting in 8-OHdG as urinary biomarker and hemangioendothelioma formation.
  • Hemangioendotheliomas are classified as endothelial cell tumors, which are the most common soft tissue tumors in infants.
  • In a murine model of hemangioendothelioma, we previously showed that MCP-1 is required for its development and that the expression of MCP-1 in EOMA cells is redox sensitive.
  • Here, we sought to identify the source of oxidants that drive hemangioendothelioma formation.
  • Nox-4 knockdown markedly attenuated MCP-1 expression and hemangioendothelioma formation.
  • The current state of information connects nox-4 to MCP-1 to form a major axis of control that regulates the fate of hemangioendothelioma development in vivo.

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  • (PMID = 19817625.001).
  • [ISSN] 1557-7716
  • [Journal-full-title] Antioxidants & redox signaling
  • [ISO-abbreviation] Antioxid. Redox Signal.
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / R01 DK076566; United States / NCRR NIH HHS / RR / UL1 RR025755; United States / NIGMS NIH HHS / GM / K08GM066964
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Ccl2 protein, mouse; 0 / Chemokine CCL2; 0 / Oxidants; 0 / RNA, Small Interfering; 88847-89-6 / 8-oxo-7-hydrodeoxyguanosine; 9007-49-2 / DNA; BBX060AN9V / Hydrogen Peroxide; EC 1.6.- / Nox4 protein, mouse; EC 1.6.3.1 / NADPH Oxidase; G9481N71RO / Deoxyguanosine
  • [Other-IDs] NLM/ PMC2935344
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42. Lee WJ: [Epithelioid hemangioendothelioma]. Korean J Hepatol; 2009 Jun;15(2):222-6
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  • [Title] [Epithelioid hemangioendothelioma].
  • [MeSH-major] Hemangioendothelioma, Epithelioid / radiography. Liver Neoplasms / radiography

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  • (PMID = 19581775.001).
  • [ISSN] 1738-222X
  • [Journal-full-title] The Korean journal of hepatology
  • [ISO-abbreviation] Korean J Hepatol
  • [Language] kor
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
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43. Honsová E, Gottfriedová H, Oliverius M, Trunecka P: Allograft hepatitis after liver transplantation for epithelioid haemangioendothelioma. Prague Med Rep; 2009;110(3):214-21
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  • [Title] Allograft hepatitis after liver transplantation for epithelioid haemangioendothelioma.
  • Primary hepatic epitheloid heamangioendothelioma (EHE) is a rare neoplasm of vascular origin.
  • [MeSH-major] Hemangioendothelioma, Epithelioid / surgery. Hepatitis / etiology. Liver Neoplasms / surgery. Liver Transplantation


44. Floris G, Deraedt K, Samson I, Brys P, Sciot R: Epithelioid hemangioma of bone: a potentially metastasizing tumor? Int J Surg Pathol; 2006 Jan;14(1):9-15; discussion 16-20
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  • Histologic examination of the foot lesion showed a typical epithelioid hemangioma of bone that extended into the soft tissues, with a secondary location in the groin, suggestive of lymph node involvement.
  • This finding suggests metastatic disease, an event that is extremely rare for epithelioid hemangioma.
  • As such, epithelioid hemangioma might be comparable to another benign vascular tumor, the retiform hemangioendothelioma, which occasionally metastasizes to the lymph nodes without systemic spread.
  • [MeSH-major] Angiolymphoid Hyperplasia with Eosinophilia / pathology. Bone Diseases / pathology. Hemangioendothelioma, Epithelioid / pathology. Lymph Nodes / pathology. Lymphatic Metastasis. Toe Phalanges / pathology
  • [MeSH-minor] Adolescent. Antigens, CD31 / analysis. Antigens, CD34 / analysis. Diagnosis, Differential. Groin. Humans. Immunohistochemistry. Keratins / analysis. Male. Radiography

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  • [Copyright] Int J Surg Pathol 14(1):9-15, 2006.
  • (PMID = 16501828.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Antigens, CD34; 68238-35-7 / Keratins
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45. Schattenberg T, Kam R, Klopp M, Herpel E, Schnabel PA, Mechtersheimer G, Dienemann H, Pfannschmidt J: Pulmonary epithelioid hemangioendothelioma: report of three cases. Surg Today; 2008;38(9):844-9
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  • [Title] Pulmonary epithelioid hemangioendothelioma: report of three cases.
  • Pulmonary epithelioid hemangioendothelioma (PEH) is a rare vascular tumor of low-grade malignancy, the prognosis of which remains unpredictable.
  • [MeSH-major] Hemangioendothelioma, Epithelioid. Lung Neoplasms

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  • (PMID = 18751952.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 30
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46. Güray Y, Demirkan B, Güray U, Boyaci A: Right atrial hemangioendothelioma: a three-dimensional echocardiographic evaluation. Anadolu Kardiyol Derg; 2010 Apr;10(2):E7-8
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  • [Title] Right atrial hemangioendothelioma: a three-dimensional echocardiographic evaluation.
  • [MeSH-major] Echocardiography, Three-Dimensional. Heart Neoplasms / ultrasonography. Hemangioendothelioma / ultrasonography
  • [MeSH-minor] Adult. Bone Neoplasms / secondary. Heart Atria / ultrasonography. Humans. Male. Neoplasm Metastasis. Palliative Care

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  • (PMID = 20382602.001).
  • [ISSN] 1308-0032
  • [Journal-full-title] Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology
  • [ISO-abbreviation] Anadolu Kardiyol Derg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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47. Maamouri F, Ennaifer Jerbi E, Tounsi Guettiti H, Boussen H, Dellagi K, Boubaker S: [Multicentric epithelioid hemangioendothelioma involving lung, mediastinum and liver]. Tunis Med; 2008 Jun;86(6):616-7
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  • [Title] [Multicentric epithelioid hemangioendothelioma involving lung, mediastinum and liver].
  • [MeSH-major] Hemangioendothelioma, Epithelioid / diagnosis. Liver Neoplasms / diagnosis. Lung Neoplasms / diagnosis. Mediastinal Neoplasms / diagnosis. Neoplasms, Multiple Primary / diagnosis


48. Hammock L, Reisenauer A, Wang W, Cohen C, Birdsong G, Folpe AL: Latency-associated nuclear antigen expression and human herpesvirus-8 polymerase chain reaction in the evaluation of Kaposi sarcoma and other vascular tumors in HIV-positive patients. Mod Pathol; 2005 Apr;18(4):463-8
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  • [Title] Latency-associated nuclear antigen expression and human herpesvirus-8 polymerase chain reaction in the evaluation of Kaposi sarcoma and other vascular tumors in HIV-positive patients.
  • Studies of vascular tumors occurring in the general population show LANA expression to be specific for Kaposi sarcoma.
  • No study to date, however, has examined whether non-Kaposi sarcoma vascular tumors arising in immunocompromised patients may express LANA, possibly reflecting origin from an HHV-8-infected endothelial progenitor cell.
  • A total of 13 cases of non-Kaposi sarcoma vascular tumors (12 hemangiomas and one epithelioid hemangioendothelioma) and 24 cases of Kaposi sarcoma, all from known HIV-positive patients, were immunostained for LANA and evaluated for the presence of HHV-8 DNA by real-time PCR.
  • This is in contrast to HHV-8 PCR, which is positive in a small subset of non-Kaposi sarcoma vascular tumors, most likely due to detection of HHV-8 within intratumoral blood mononuclear cells by the highly sensitive real-time PCR technique.
  • For this reason, LANA immunohistochemistry is preferable to HHV-8 PCR for the evaluation of problematic vascular proliferations in HIV-positive individuals.
  • [MeSH-major] HIV Infections / complications. Hemangioma / diagnosis. Herpesvirus 8, Human / genetics. Nuclear Proteins / biosynthesis. Sarcoma, Kaposi / diagnosis
  • [MeSH-minor] Adult. Antigens, Viral. DNA, Viral / genetics. Female. HIV Seropositivity. Hemangioendothelioma / complications. Hemangioendothelioma / diagnosis. Hemangioendothelioma / metabolism. Humans. Immunohistochemistry. Male. Middle Aged. Polymerase Chain Reaction / methods


49. Al-Tonbary Y, Fouda A: Infantile hepatic hemangioendothelioma: an 8-month old infant successfully treated with a corticosteroid. Hematol Oncol Stem Cell Ther; 2009;2(3):422-5
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  • [Title] Infantile hepatic hemangioendothelioma: an 8-month old infant successfully treated with a corticosteroid.
  • Infantile hemangioendothelioma is a rare benign vascular tumor of the liver.
  • We report a case of hepatic hemangioendothelioma in an 8- month-old female infant who presented with hepatomegaly and respiratory distress, which was successfully treated with oral prednisolone for six months.
  • [MeSH-major] Anti-Inflammatory Agents / therapeutic use. Hemangioendothelioma / drug therapy. Liver Neoplasms / drug therapy. Prednisolone / therapeutic use

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  • (PMID = 20139057.001).
  • [ISSN] 1658-3876
  • [Journal-full-title] Hematology/oncology and stem cell therapy
  • [ISO-abbreviation] Hematol Oncol Stem Cell Ther
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Saudi Arabia
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 9PHQ9Y1OLM / Prednisolone
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50. Chen TT, Lai CT, Wu CL, Wang TY, Shih BF, Hung CL, Kuo LK, Weng YL, Lee SY: Cardiac tamponade caused by epithelioid haemangioendothelioma. BMJ Case Rep; 2009;2009
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  • [Title] Cardiac tamponade caused by epithelioid haemangioendothelioma.
  • Epithelioid haemangioendothelioma (EHE) is a tumour of vascular endothelial origin.
  • The rarity of EHE has limited the complete understanding of the disease.

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  • (PMID = 21686542.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3027560
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51. de Wind A, Meert V, Chahidi N, Theunis A, Somerhausen Nde S: [Retiform haemangioendothelioma: a case report]. Ann Pathol; 2009 Dec;29(6):491-4
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  • [Title] [Retiform haemangioendothelioma: a case report].
  • Retiform haemangioendothelioma is a locally aggressive, very rarely metastasizing vascular lesion.
  • Histologically, it is characterized by distinctive arborizing blood vessels resembling "rete testis" and lined by endothelial cells with characteristic hobnail morphology.
  • We discuss the classification of hemangioendotheliomas.
  • The term hemangioendothelioma should be restricted to vascular tumours of "intermediate malignancy" but has been used to designate tumours with variable histological features and clinical behaviour.
  • Spindle cell hemangio(endothelio)ma is currently regarded as a benign reactive lesion.
  • Kaposiform hemangioendothelioma is potentially lethal due to consumption coagulopathy but no metastasizing case has been reported.
  • Epithelioid hemangioendothelioma is associated with a significant metastatic risk and has been included in the category of malignant vascular tumors.
  • The vascular lesions fulfilling the strict definition of hemangioendothelioma include retiform hemangioendothelioma, papillary intralymphatic angioendothelioma "Dabska's tumor", composite hemangioendothelioma and perhaps the controversial polymorphic hemangioendothelioma.
  • [MeSH-major] Hemangioendothelioma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Antigens, CD / analysis. Antigens, CD31 / analysis. Antigens, CD34 / analysis. Endothelium, Vascular / pathology. Humans. Male. Middle Aged. Neoplasm Metastasis. Tibia / pathology. Vascular Neoplasms / pathology

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  • (PMID = 20005438.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD31; 0 / Antigens, CD34
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52. Wang LF, Liu M, Zhu H, Han W, Hu CY, Qi JP, Mei HL, Ge RL, Zhou M: Primary cardiac hemangioendothelioma: a case report. Chin Med J (Engl); 2006 Jun 5;119(11):966-8
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  • [Title] Primary cardiac hemangioendothelioma: a case report.
  • [MeSH-major] Heart Neoplasms / pathology. Hemangioendothelioma / pathology

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  • [CommentIn] Chin Med J (Engl). 2006 Dec 5;119(23):2021 [17199949.001]
  • (PMID = 16780780.001).
  • [ISSN] 0366-6999
  • [Journal-full-title] Chinese medical journal
  • [ISO-abbreviation] Chin. Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
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53. Fujii T, Zen Y, Sato Y, Sasaki M, Enomae M, Minato H, Masuda S, Uehara T, Katsuyama T, Nakanuma Y: Podoplanin is a useful diagnostic marker for epithelioid hemangioendothelioma of the liver. Mod Pathol; 2008 Feb;21(2):125-30
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  • [Title] Podoplanin is a useful diagnostic marker for epithelioid hemangioendothelioma of the liver.
  • Podoplanin, which is immunoreactive to D2-40 antibody, is reportedly expressed in lymphatic vessels in non-neoplastic tissues, and also in vascular and non-vascular tumors.
  • In this study, we examined podoplanin expression in specimens from 10 normal livers and 73 cases of liver tumors: hemangioma (16 cases), epithelioid hemangioendothelioma (9 cases), angiosarcoma (4 cases), angiomyolipoma (7 cases), hepatocellular carcinoma (11 cases), intrahepatic cholangiocarcinoma (11 cases), and metastatic liver cancer (15 cases).
  • Among liver tumors, podoplanin was specifically expressed in seven of nine cases (78%) of epithelioid hemangioendothelioma but not in other hepatic tumors.
  • The expression of CD31, CD34, and factor VIII was observed in endothelial cells in all cases of hemangioma, epithelioid hemangioendothelioma, angiosarcoma, and angiomyolipoma with one exception, a case of epithelioid hemangioendothelioma which was without CD31 expression.
  • In conclusion, podoplanin would be useful as a diagnostic marker for epithelioid hemangioendothelioma in liver tumors.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Hemangioendothelioma, Epithelioid / metabolism. Liver Neoplasms / metabolism. Membrane Glycoproteins / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Angiomyolipoma / metabolism. Angiomyolipoma / pathology. Bile Duct Neoplasms / metabolism. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / metabolism. Bile Ducts, Intrahepatic / pathology. Carcinoma, Hepatocellular / metabolism. Carcinoma, Hepatocellular / pathology. Cholangiocarcinoma / metabolism. Cholangiocarcinoma / pathology. Diagnosis, Differential. Endothelium, Lymphatic / metabolism. Endothelium, Lymphatic / pathology. Female. Hemangioma / metabolism. Hemangioma / pathology. Hemangiosarcoma / metabolism. Hemangiosarcoma / pathology. Humans. Liver / metabolism. Liver / pathology. Male. Middle Aged

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  • (PMID = 18084256.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Membrane Glycoproteins; 0 / PDPN protein, human
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54. Woller SC, Boschert ME, Hutson WR: Hepatic epithelioid hemangioendothelioma presenting as liver infarction. Clin Gastroenterol Hepatol; 2005 Feb;3(2):xx
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  • [Title] Hepatic epithelioid hemangioendothelioma presenting as liver infarction.
  • [MeSH-major] Hemangioendothelioma, Epithelioid / diagnosis. Infarction / diagnosis. Liver Neoplasms / diagnosis. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Liver Diseases / diagnosis. Prognosis. Risk Assessment

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  • (PMID = 15704041.001).
  • [ISSN] 1542-3565
  • [Journal-full-title] Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • [ISO-abbreviation] Clin. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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55. Larochelle O, Périgny M, Lagacé R, Dion N, Giguère C: Best cases from the AFIP: epithelioid hemangioendothelioma of bone. Radiographics; 2006 Jan-Feb;26(1):265-70
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  • [Title] Best cases from the AFIP: epithelioid hemangioendothelioma of bone.
  • [MeSH-major] Bone Neoplasms / diagnosis. Hemangioendothelioma, Epithelioid / diagnosis

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  • (PMID = 16418256.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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56. Rodgers B, Zeim S, Crawford B, Neitzschman H, Daroca P, Scher CD: Splenic papillary angioendothelioma in a 6-year-old girl. J Pediatr Hematol Oncol; 2007 Dec;29(12):808-10
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  • [Title] Splenic papillary angioendothelioma in a 6-year-old girl.
  • Papillary angioendothelioma is a rare, low-grade neoplasm of lymphatic channels that usually presents intradermally.
  • We report the case of a 6-year-old girl with isolated splenomegaly and symptoms of early satiety and weight loss, whom was found to have a splenic papillary angioendothelioma.
  • Subsequent surgery and pathologic assessment revealed a papillary angioendothelioma (Dabska tumor) within lymphatic spaces.
  • [MeSH-major] Hemangioendothelioma / radiography. Hemangioendothelioma / surgery. Splenic Neoplasms / radiography. Splenic Neoplasms / surgery

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  • (PMID = 18090926.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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57. López V, Martí N, Pereda C, Martín JM, Ramón D, Mayordomo E, Jordá E: Successful management of Kaposiform hemangioendothelioma with Kasabach-Merritt phenomenon using vincristine and ticlopidine. Pediatr Dermatol; 2009 May-Jun;26(3):365-6
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  • [Title] Successful management of Kaposiform hemangioendothelioma with Kasabach-Merritt phenomenon using vincristine and ticlopidine.
  • Kaposiform hemangioendothelioma is a rare locally aggressive vascular tumor that usually occurs in skin and retroperitoneum of infants and young children.
  • [MeSH-major] Antineoplastic Agents, Phytogenic / administration & dosage. Blood Coagulation Disorders / complications. Fibrinolytic Agents / administration & dosage. Hemangioendothelioma / drug therapy. Skin Neoplasms / drug therapy. Ticlopidine / administration & dosage. Vincristine / administration & dosage


58. Arcos-Quirós C, Fernández-Balaguer P, Domínguez-Tristancho JL, García-Fidalgo G: [Hepatic epithelioid haemangioendothelioma presenting as hepatic hydatidosis]. Cir Esp; 2009 Jun;85(6):381-2
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  • [Title] [Hepatic epithelioid haemangioendothelioma presenting as hepatic hydatidosis].
  • [Transliterated title] Presentación de un hemangioendotelioma epiteloide hepático como hidatidosis hepática.
  • [MeSH-major] Echinococcosis, Hepatic / pathology. Hemangioendothelioma, Epithelioid / pathology. Liver Neoplasms / pathology

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  • (PMID = 19406385.001).
  • [ISSN] 0009-739X
  • [Journal-full-title] Cirugía española
  • [ISO-abbreviation] Cir Esp
  • [Language] spa
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Spain
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59. Siddaraju N, Soundararaghavan J, Bundele MM, Roy SK: Fine needle aspiration cytology of epithelioid angiosarcoma: a case report. Acta Cytol; 2008 Jan-Feb;52(1):109-13
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  • BACKGROUND: Malignant vascular tumors are rare.
  • Few studies have described cytomorphologic features of hemangioendothelioma and angiosarcoma on fine needle aspiration cytology (FNAC).
  • Malignant vascular tumor with epithelioid morphology can create diagnostic difficulty, as the cytology may simulate that in other nonvascular malignant tumors.
  • We describe epithelioid angiosarcoma, diagnosed on FNAC, in which a differential diagnosis of histiocytosis and inflammatory granulation tissue was considered.
  • FNA resulted in high cellular yield, and smears revealed prominent vascular pattern with endothelial cell atypia and histiocytoid/epithelioid neoplastic cells, occasional mitotic figures and a few cells displaying nuclear grooving.
  • Epithelioid hemangioendothelioma/angiosarcoma, histiocytosis and inflammatory granulation tissue were considered.
  • A cytologic diagnosis of epithelioid angiosarcoma/epithelioid hemangioendothelioma was suggested and confirmed on histopathologic and immunohistochemical examination.
  • CONCLUSION: Cellular aspirates from malignant epithelioid endothelial tumors involving bone may be cytologically mistaken for histiocytosis and, rarely, inflammatory granulation tissue.
  • However, prominent vascular pattern with striking endothelial cell atypia, presence of mitotic figures and careful search for presence of endothelial differentiation are helpful in accurate cytologic diagnosis.
  • [MeSH-major] Bone Neoplasms / diagnosis. Hemangioendothelioma, Epithelioid / diagnosis. Hemangiosarcoma / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Biomarkers, Tumor / analysis. Diagnosis, Differential. Granulation Tissue / pathology. Histiocytosis / diagnosis. Humans. Immunohistochemistry. Inflammation / diagnosis. Male

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  • (PMID = 18323286.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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60. Sari N, Yalçin B, Akyüz C, Haliloglu M, Büyükpamukçu M: Infantile hepatic hemangioendothelioma with elevated serum alpha-fetoprotein. Pediatr Hematol Oncol; 2006 Dec;23(8):639-47
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  • [Title] Infantile hepatic hemangioendothelioma with elevated serum alpha-fetoprotein.
  • Infantile hemangioendothelioma is the most common hepatic vascular tumor in infants less than 6 months of age, with a prevalence of 1%.
  • It is rarely elevated in hepatic hemangioendothelioma.
  • The authors report an infant with a hepatic hemangioendothelioma associated with elevation of serum alpha-fetoprotein who was treated with corticosteroids.
  • Infantile hemangioendothelioma must be differentiated by MRI or other radiological techniques before performing invasive procedures.
  • [MeSH-major] Biomarkers, Tumor / blood. Hemangioendothelioma / blood. Liver Neoplasms / blood. Neoplasm Proteins / blood. alpha-Fetoproteins / analysis
  • [MeSH-minor] Age Factors. Antineoplastic Agents / therapeutic use. Carcinoma, Hepatocellular / diagnosis. Diagnosis, Differential. Humans. Infant, Newborn. Magnetic Resonance Imaging. Male. Methylprednisolone / therapeutic use. Remission Induction

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  • (PMID = 17065140.001).
  • [ISSN] 1521-0669
  • [Journal-full-title] Pediatric hematology and oncology
  • [ISO-abbreviation] Pediatr Hematol Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; 0 / alpha-Fetoproteins; X4W7ZR7023 / Methylprednisolone
  • [Number-of-references] 24
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61. Tosios KI, Gouveris I, Sklavounou A, Koutlas IG: Spindle cell hemangioma (hemangioendothelioma) of the head and neck: case report of an unusual (or underdiagnosed) tumor. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2008 Feb;105(2):216-21
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  • [Title] Spindle cell hemangioma (hemangioendothelioma) of the head and neck: case report of an unusual (or underdiagnosed) tumor.
  • Spindle cell hemangioma (SCH), also known as spindle cell hemangioendothelioma, is a unique vascular tumor with combined microscopic features of both a cavernous hemangioma and Kaposi sarcoma.
  • A review of the literature disclosed only 5 cases of SCH reported in detail in the soft tissues of the head and neck.
  • [MeSH-major] Hemangioendothelioma, Epithelioid / pathology. Lip Neoplasms / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans

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  • (PMID = 17656123.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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62. Layfield LJ, Skripenova S, Bentz J, Smock C: Cytologic fine needle aspiration findings by vegetant intravascular hemangioendothelioma. Acta Cytol; 2008 Mar-Apr;52(2):273-5
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  • [Title] Cytologic fine needle aspiration findings by vegetant intravascular hemangioendothelioma.
  • [MeSH-major] Biopsy, Fine-Needle. Hemangioendothelioma, Epithelioid / pathology. Vascular Neoplasms / pathology

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  • (PMID = 18500014.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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63. Fasolis M, Iaquinta C, Montesco MC, Garzino-Demo P, Tosco P, Tanteri G, Bonandini E, Ninfo V, Berrone S: Composite hemangioendothelioma of the oral cavity: case report and review of the literature. Head Neck; 2008 Jul;30(7):974-9
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  • [Title] Composite hemangioendothelioma of the oral cavity: case report and review of the literature.
  • BACKGROUND: Composite hemangioendothelioma is a rare histopathologic feature, which is part of the hemangioendothelioma family.
  • This is a heterogeneous group of vascular neoplasia with a high tendency to local relapse but a rare predisposition to metastatic spread.
  • Composite hemangioendothelioma mainly affects adults and is usually localized in the distal extremity of the limbs.
  • METHODS: A case of composite hemangioendothelioma in a 38-year-old man is reported.
  • CONCLUSION: This case demonstrates how a composite hemangioendothelioma histological diagnosis can be difficult to achieve.
  • [MeSH-major] Hemangioendothelioma / pathology. Hemangioendothelioma / surgery. Mouth Neoplasms / pathology. Mouth Neoplasms / surgery

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  • (PMID = 18286494.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 11
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64. Zhu Y, Cuevas IC, Gabriel RA, Su H, Nishimura S, Gao P, Fields A, Hao Q, Young WL, Yang GY, Boudreau NJ: Restoring transcription factor HoxA5 expression inhibits the growth of experimental hemangiomas in the brain. J Neuropathol Exp Neurol; 2009 Jun;68(6):626-32
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  • Hemangiomas are angiogenesis-dependent benign vascular tumors that can rupture and cause intracranial hemorrhages.
  • Here, we investigated whether restoring expression of HoxA5 blocks hemangioma growth by transplanting mouse hemangioendothelioma endothelial cells (EOMA) or HoxA5-expressing EOMA cells into the brains of mice.

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  • (PMID = 19458547.001).
  • [ISSN] 0022-3069
  • [Journal-full-title] Journal of neuropathology and experimental neurology
  • [ISO-abbreviation] J. Neuropathol. Exp. Neurol.
  • [Language] ENG
  • [Grant] United States / NINDS NIH HHS / NS / R21 NS050668-02; United States / NINDS NIH HHS / NS / P01 NS044155-05; United States / NINDS NIH HHS / NS / R21 NS050668; United States / NINDS NIH HHS / NS / P01 NS044155; United States / NINDS NIH HHS / NS / R01 NS027713; United States / NINDS NIH HHS / NS / R01 NS27713; United States / NINDS NIH HHS / NS / NS044155-05; United States / NINDS NIH HHS / NS / NS027713-17; United States / NINDS NIH HHS / NS / R21 NS50668; United States / NINDS NIH HHS / NS / P01 NS44145; United States / NINDS NIH HHS / NS / R01 NS027713-17; United States / NINDS NIH HHS / NS / NS050668-02
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Actins; 0 / Hif1a protein, mouse; 0 / Homeodomain Proteins; 0 / Hoxa5 protein, mouse; 0 / Hypoxia-Inducible Factor 1, alpha Subunit; 0 / Lectins; 0 / Phosphoproteins; 0 / RNA, Messenger; 0 / Thrombospondins; 0 / thrombospondin 2
  • [Other-IDs] NLM/ NIHMS118393; NLM/ PMC2728585
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65. Mukerji SS, Osborn AJ, Roberts J, Valdez TA: Kaposiform hemangioendothelioma (with Kasabach Merritt syndrome) of the head and neck: case report and review of the literature. Int J Pediatr Otorhinolaryngol; 2009 Oct;73(10):1474-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Kaposiform hemangioendothelioma (with Kasabach Merritt syndrome) of the head and neck: case report and review of the literature.
  • Diagnosis of Kaposiform hemangioendothelioma was confirmed with biopsy.
  • Kaposiform hemangioendothelioma is a rare head and neck tumor that may be mistaken for a hemangioma on preliminary diagnosis, which may lead to increased morbidity and mortality especially in the setting of Kasabach-Merritt phenomenon.
  • A platelet count may provide an early and important clue to the possibility of coagulopathy; prompting physicians to look for a diagnosis other than a simple hemangioma.
  • [MeSH-major] Laryngeal Neoplasms / diagnosis. Multiple Organ Failure / diagnosis
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Disease Progression. Disseminated Intravascular Coagulation / diagnosis. Disseminated Intravascular Coagulation / therapy. Fatal Outcome. Female. Hemangioendothelioma / diagnosis. Hemangioendothelioma / therapy. Hemangioma, Capillary / diagnosis. Hemangioma, Capillary / therapy. Hemangioma, Cavernous / diagnosis. Hemangioma, Cavernous / therapy. Humans. Infant, Newborn. Kasabach-Merritt Syndrome. Laryngoscopy / methods. Magnetic Resonance Imaging / methods. Risk Assessment. Sarcoma, Kaposi / diagnosis. Sarcoma, Kaposi / therapy. Severity of Illness Index. Skin Neoplasms / diagnosis. Skin Neoplasms / therapy. Thrombocytopenia / diagnosis. Thrombocytopenia / therapy. Tracheostomy / methods. Vascular Neoplasms / diagnosis. Vascular Neoplasms / therapy


66. Pai KR, Thonse VR, Azadeh B, Page RD: Ectopic thymoma of the chest wall. Interact Cardiovasc Thorac Surg; 2005 Feb;4(1):9-11
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  • A chest wall tumour involving the third and fourth ribs and extending extrapleurally and subpectorally was resected following a histopathological diagnosis of hemangioendothelioma obtained at initial incision biopsy.
  • No primary thymic tumour was present in the anterior mediastinum so we conclude that the tumour originated in ectopic thymic tissue.

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  • (PMID = 17670343.001).
  • [ISSN] 1569-9285
  • [Journal-full-title] Interactive cardiovascular and thoracic surgery
  • [ISO-abbreviation] Interact Cardiovasc Thorac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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67. Eckardt A, Swennen G, Barth EL, Brachvogel P: Long-term results after mandibular continuity resection in infancy: the role of autogenous rib grafts for mandibular restoration. J Craniofac Surg; 2006 Mar;17(2):255-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Histologic diagnoses were melanotic neuroectodermal tumor, hemangioendothelioma of the mandible, and ameloblastoma.
  • [MeSH-minor] Ameloblastoma / rehabilitation. Ameloblastoma / surgery. Child, Preschool. Female. Follow-Up Studies. Hemangioendothelioma / rehabilitation. Hemangioendothelioma / surgery. Humans. Infant. Male. Maxillofacial Development. Neuroectodermal Tumor, Melanotic / rehabilitation. Neuroectodermal Tumor, Melanotic / surgery. Ribs / transplantation

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  • (PMID = 16633171.001).
  • [ISSN] 1049-2275
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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68. Karasavvidou F, Barbanis S, Gravas S, Ioannou M, Oeconomou A, Pappa D, Melekos MD, Koukoulis G: Primary renal epithelioid hemangioendothelioma. Onkologie; 2009 Apr;32(4):203-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary renal epithelioid hemangioendothelioma.
  • BACKGROUND: Epithelioid hemangioendothelioma (EH) is a rare vascular neoplasm with an unpredictable malignant potential that has been described mainly in soft tissue, liver, and lung.
  • On the basis of the histological and immunohistochemical findings, the diagnosis of EH was made.
  • The patient was free of disease 6 months after surgery.
  • CONCLUSIONS: Although EH may have a histologically benign appearance and can be treated using a nephron-sparing approach, this neoplasm is potentially malignant urging the need for a long-term follow-up in these patients.
  • [MeSH-major] Abdominal Pain / etiology. Hemangioendothelioma, Epithelioid / complications. Hemangioendothelioma, Epithelioid / diagnosis. Kidney Neoplasms / complications. Kidney Neoplasms / diagnosis

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  • [Copyright] Copyright 2009 S. Karger AG, Basel.
  • (PMID = 19372717.001).
  • [ISSN] 1423-0240
  • [Journal-full-title] Onkologie
  • [ISO-abbreviation] Onkologie
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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69. Gruman A, Liang MG, Mulliken JB, Fishman SJ, Burrows PE, Kozakewich HP, Blei F, Frieden IJ: Kaposiform hemangioendothelioma without Kasabach-Merritt phenomenon. J Am Acad Dermatol; 2005 Apr;52(4):616-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Kaposiform hemangioendothelioma without Kasabach-Merritt phenomenon.
  • Kasabach-Merritt phenomenon is a serious coagulopathy associated with kaposiform hemangioendothelioma (KHE), tufted angioma, and possibly other vascular neoplasms.
  • The tumors appeared as soft tissue masses with the overlying skin being either normal, erythematous, or violaceous.
  • [MeSH-major] Hemangioendothelioma / diagnosis. Skin Neoplasms / diagnosis


70. Malagón HD, Valdez AM, Moran CA, Suster S: Germ cell tumors with sarcomatous components: a clinicopathologic and immunohistochemical study of 46 cases. Am J Surg Pathol; 2007 Sep;31(9):1356-62
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  • The SC included embryonal rhabdomyosarcoma (29), angiosarcoma (6), leiomyosarcoma (4), undifferentiated sarcoma (3), myxoid liposarcoma (1), malignant peripheral nerve sheath tumor (1), malignant "triton" tumor (1), and epithelioid hemangioendothelioma (1).
  • Thirty-two of 40 patients either died of tumor (25/40; 62.5%) or were alive with advanced, progressive disease (7/40; 17.5%), and only 8/40 (20%) were alive and free of disease between 5 to 40 months (mean=18 mo).
  • [MeSH-major] Immunohistochemistry. Mediastinal Neoplasms / diagnosis. Neoplasms, Germ Cell and Embryonal / diagnosis. Ovarian Neoplasms / diagnosis. Retroperitoneal Neoplasms / diagnosis. Sarcoma / diagnosis. Testicular Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Antineoplastic Combined Chemotherapy Protocols. Disease-Free Survival. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Metastasis. Neoplasm Staging. Orchiectomy. Ovariectomy. Time Factors. Treatment Outcome

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  • (PMID = 17721191.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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71. Sun H, Qin M, Xiao Y, Yang F, Ni W, Liu S: Haemangiomas, leiomyosarcoma and myeloma caused by subgroup J avian leukosis virus in a commercial layer flock. Acta Vet Hung; 2010 Dec;58(4):441-51
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  • Histopathologically, haemangiomas were typically cavernous haemangiomas and haemangioendothelioma.
  • Immunohistochemistry for vimentin, cytokeratin, actin (smooth muscle) and actin (sarcomeric) and Masson's staining confirmed the different cell lineage of the nodular tumour, thus leading to the diagnosis of leiomyosarcoma.
  • [MeSH-major] Avian Leukosis Virus / isolation & purification. Disease Outbreaks / veterinary. Hemangioma / veterinary. Leiomyosarcoma / veterinary. Neoplasms, Plasma Cell / veterinary. Poultry Diseases / virology

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  • (PMID = 21087914.001).
  • [ISSN] 0236-6290
  • [Journal-full-title] Acta veterinaria Hungarica
  • [ISO-abbreviation] Acta Vet. Hung.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Hungary
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72. Chen RL, Chang PY, Hsu YH, Chang YH, Peng HC: Recurrent life-threatening hemothorax in an infant with pleurocutaneous kaposiform hemangio-endothelioma. J Pediatr Hematol Oncol; 2006 Sep;28(9):630-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recurrent life-threatening hemothorax in an infant with pleurocutaneous kaposiform hemangio-endothelioma.
  • [MeSH-major] Hemangioendothelioma / complications. Hemothorax / etiology. Neoplasm Recurrence, Local / complications. Pleural Neoplasms / pathology. Thoracic Wall / pathology

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  • [CommentOn] J Pediatr Hematol Oncol. 2005 Nov;27(11):596-8 [16282890.001]
  • (PMID = 17006273.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Comment; Letter
  • [Publication-country] United States
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73. DeFatta RJ, Verret DJ, Adelson RT, Gomez A, Myers LL: Kaposiform hemangioendothelioma: case report and literature review. Laryngoscope; 2005 Oct;115(10):1789-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Kaposiform hemangioendothelioma: case report and literature review.
  • We report the identification of a kaposiform hemangioendothelioma (KH) in the oropharynx of a 3-year-old boy.
  • This is a rare endothelial-derived spindle cell neoplasm affecting children and early adolescents with features common to capillary hemangioma and Kaposi sarcoma.
  • KH should be considered in the differential diagnosis of a vascular lesion demonstrating unexpected behavior from that of a hemangioma.
  • [MeSH-major] Hemangioendothelioma / diagnosis. Mouth Neoplasms / diagnosis. Sarcoma / diagnosis


74. Egberts F, Mentzel T, Leuschner I, Metzler G, Fölster-Holst R: Metastasizing epithelioid hemangioendothelioma of the nose in childhood. J Cutan Pathol; 2008 Oct;35 Suppl 1:80-2
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  • [Title] Metastasizing epithelioid hemangioendothelioma of the nose in childhood.
  • Epithelioid hemangioendothelioma (EHE) arising in the skin is extremely rare, and the majority of documented cases have developed in soft tissues or parenchymatous organs.
  • Immunohistochemical stainings confirmed the vascular nature of the tumor.
  • On the basis of these findings, the diagnosis of an EHE was made.
  • Eighteen months after diagnosis, there is no evidence of local tumor recurrence or metastases.
  • As our case shows, this rare tumor entity has to be considered as a differential diagnosis in neoplasms of the skin, even in childhood.
  • [MeSH-major] Hemangioendothelioma, Epithelioid / pathology. Lymphatic Metastasis / pathology. Nose Neoplasms / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Child. Cysts / pathology. Diagnosis, Differential. Humans. Immunohistochemistry. Interferon-alpha / therapeutic use. Male. Microscopy, Confocal. Pilomatrixoma / pathology. Recombinant Proteins

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  • [Copyright] Copyright Blackwell Munksgaard 2008.
  • (PMID = 18544051.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Interferon-alpha; 0 / Recombinant Proteins; 99210-65-8 / interferon alfa-2b
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75. Semino L, Pagella F, Delù G, Todeschini A, Luinetti O, Zappoli F, Castelnuovo P: Endoscopic treatment of ethmoidal hemangioendothelioma: case report and review of the literature. Am J Otolaryngol; 2006 Jul-Aug;27(4):287-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Endoscopic treatment of ethmoidal hemangioendothelioma: case report and review of the literature.
  • Hemangioendothelioma (HE) is a rare vascular tumor of endothelial cell origin that usually involves long bone or soft tissue.
  • [MeSH-major] Ethmoid Sinus / surgery. Hemangioendothelioma / surgery. Paranasal Sinus Neoplasms / surgery

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  • (PMID = 16798411.001).
  • [ISSN] 0196-0709
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 21
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76. Guiteau JJ, Cotton RT, Karpen SJ, O'Mahony CA, Goss JA: Pediatric liver transplantation for primary malignant liver tumors with a focus on hepatic epithelioid hemangioendothelioma: the UNOS experience. Pediatr Transplant; 2010 May;14(3):326-31
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  • [Title] Pediatric liver transplantation for primary malignant liver tumors with a focus on hepatic epithelioid hemangioendothelioma: the UNOS experience.
  • [MeSH-major] Hemangioendothelioma, Epithelioid / surgery. Liver Neoplasms / surgery. Liver Transplantation
  • [MeSH-minor] Child. Child, Preschool. Female. Graft Survival. Humans. Infant. Male. Neoplasm Recurrence, Local. Risk Factors. Survival Analysis. Treatment Outcome


77. Fotiadis C, Georgopoulos I, Stoidis C, Patapis P: Primary tumors of the spleen. Int J Biomed Sci; 2009 Jun;5(2):85-91
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  • The most common nonlymphoid tumors are the vascular tumors which include benign and malignant haemangiomas, littoral cell angiomas, lymphangiomas and haemangioendotheliomas.

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  • (PMID = 23675122.001).
  • [ISSN] 1550-9702
  • [Journal-full-title] International journal of biomedical science : IJBS
  • [ISO-abbreviation] Int J Biomed Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3614769
  • [Keywords] NOTNLM ; metastatic / primary / spleen / tumors
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78. Aydingöz IE, Demirkesen C, Serdar ZA, Mansur AT, Yaşar S, Aslan C: Composite haemangioendothelioma with lymph-node metastasis: an unusual presentation at an uncommon site. Clin Exp Dermatol; 2009 Dec;34(8):e802-6
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  • [Title] Composite haemangioendothelioma with lymph-node metastasis: an unusual presentation at an uncommon site.
  • Three months later, upon recurrence of the lesions, a diagnosis of composite haemangioendothelioma (CHE) was made.
  • Although CHE is defined as a vascular tumour with low-grade malignancy, the local recurrences and lymph-node metastases resulted in treatment difficulties in this case.
  • Dermatologists and pathologists should be aware of this rare condition and include it in the differential diagnosis of vascular lesions.
  • [MeSH-major] Hemangioendothelioma / secondary. Skin Neoplasms / pathology

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  • (PMID = 20055844.001).
  • [ISSN] 1365-2230
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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79. Madry H, Prudlo J, Grgic A, Freyschmidt J: Nasu-Hakola disease (PLOSL): report of five cases and review of the literature. Clin Orthop Relat Res; 2007 Jan;454:262-9
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  • [Title] Nasu-Hakola disease (PLOSL): report of five cases and review of the literature.
  • The combination of bilateral lytic lesions in the bones of the lower and upper extremities and presenile dementia is characteristic of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy, also known as Nasu-Hakola disease.
  • The clinical course of this rare and fatal disorder is characterized by pathologic fractures of these often painful lesions, rapid progression of dementia, and death in the fifth decade of life.
  • The radiographic changes may be confused with cystic angiomatosis, focal metastasizing hemangioendothelioma, or Langerhans' cell histiocytosis.
  • A biopsy is not needed to confirm the diagnosis of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy because of the unique combination of radiographic and neurologic features.
  • [MeSH-major] Alzheimer Disease / pathology. Lipodystrophy / pathology. Osteochondrodysplasias / pathology
  • [MeSH-minor] Adult. Angiomatosis / diagnosis. Biopsy. Diagnosis, Differential. Female. Hemangioendothelioma / diagnosis. Histiocytosis, Langerhans-Cell / diagnosis. Humans. Male. Middle Aged


80. Liu DG, Ma XC, Li BM, Zhang JG: Clinical study of preoperative angiography and embolization of hypervascular neoplasms in the oral and maxillofacial region. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2006 Jan;101(1):102-9
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  • METHODS: Angiograms and operation records of 25 patients with hypervascular neoplasms (23 neck paragangliomas, 1 hemangiopericytoma, and 1 hemangioendothelioma) were retrospectively analyzed, and the effects of 8 embolization procedures were estimated.
  • RESULTS: Angiograms demonstrated that 23 neck paragangliomas (NPs) were manifested as richly vascularized lesions, and were divided into 3 types.
  • In 6 type II paraganglioma cases intra-arterial embolization was employed and the paragangliomas were removed with less blood loss (238 mL) than the nonembolized group (600 mL).
  • Additionally, the infratemporal hemangiopericytoma and the parotid hemangioendothelioma were embolized and removed uneventfully.
  • CONCLUSIONS: Angiographic studies are highly valuable for the diagnosis and preoperative analysis of hypervascular head and neck neoplasms.
  • Also, embolization therapy may minimize intraoperative blood loss.
  • [MeSH-major] Carotid Artery, Common / radiography. Head and Neck Neoplasms / blood supply. Paraganglioma / blood supply
  • [MeSH-minor] Adolescent. Adult. Blood Loss, Surgical / prevention & control. Cerebrovascular Circulation. Circle of Willis / radiography. Embolization, Therapeutic. Female. Hemangioendothelioma / blood supply. Hemangioendothelioma / radiography. Hemangioendothelioma / surgery. Hemangiopericytoma / blood supply. Hemangiopericytoma / radiography. Hemangiopericytoma / surgery. Humans. Male. Middle Aged. Neck. Preoperative Care. Retrospective Studies. Tomography, X-Ray Computed

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  • (PMID = 16360614.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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81. Ye B, Li W, Liu XY, Sun KL, Yang LH, Ma K, Zhao SH, Mao YS: Multiple organ metastases of Pulmonary Epithelioid Haemangioendothelioma and a review of the literature. Med Oncol; 2010 Mar;27(1):49-54
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  • [Title] Multiple organ metastases of Pulmonary Epithelioid Haemangioendothelioma and a review of the literature.
  • This report describes a case of pulmonary epithelioid haemangioendothelioma presented as multi-organ metastases including lung, liver and bone in a 56-year-old woman with an initial diagnosis made with thoracoscopic wedge biopsy.
  • The diagnosis is confirmed through immunohistochemistry.
  • This is a rare disease, with approximately 90 cases described in the English literature and approximately 10 cases reported in China.
  • [MeSH-major] Bone Neoplasms / secondary. Hemangioendothelioma, Epithelioid / pathology. Liver Neoplasms / secondary. Lung Neoplasms / pathology. Lung Neoplasms / secondary

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  • (PMID = 19277914.001).
  • [ISSN] 1559-131X
  • [Journal-full-title] Medical oncology (Northwood, London, England)
  • [ISO-abbreviation] Med. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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82. Cobianchi L, Lucioni M, Rosso R, Zonta S, Fiandrino G, Alessiani M, Doni M, Ferrari A, Magrini U, Paulli M, Dionigi P: Unique vascular tumor primary arising in the liver and exhibiting histopathological features consistent with so-called polymorphous hemangioendothelioma. Pathol Int; 2009 Dec;59(12):890-4
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  • [Title] Unique vascular tumor primary arising in the liver and exhibiting histopathological features consistent with so-called polymorphous hemangioendothelioma.
  • Reported herein is an unusual vascular tumor primary arising in the liver and exhibiting unique histopathological features.
  • These findings led to the diagnosis of a low-grade vascular neoplasm with morphological features consistent with so-called polymorphous hemangioendothelioma.
  • At 24 month follow up the patient was alive, without evidence of disease.
  • Polymorphous hemangioendothelioma is a rare vascular neoplasm, with borderline malignant potential, which usually occurs in lymph nodes and, rarely, at extranodal sites.
  • The unusual morphological features of the present case, which do not fit neatly with any other recognized hemangioendothelioma subtype, indicate that the family of vascular tumors is broader than currently accepted.
  • In addition the present case widens the spectrum of primary vascular tumors arising in the liver.
  • [MeSH-major] Hemangioendothelioma / pathology. Liver Neoplasms / pathology

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  • (PMID = 20021616.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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83. Carvalho T, Pinto C, Peleteiro MC: Urinary bladder lesions in bovine enzootic haematuria. J Comp Pathol; 2006 May;134(4):336-46
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  • The large number of tumours examined (870) revealed new categories not yet included in other veterinary classification systems, namely, inverted papilloma, papillary neoplasm of apparent low malignant potential, and haemangioendothelioma.

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  • (PMID = 16714029.001).
  • [ISSN] 0021-9975
  • [Journal-full-title] Journal of comparative pathology
  • [ISO-abbreviation] J. Comp. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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84. Papla B: Endothelial neoplasms of the lungs. Pol J Pathol; 2008;59(2):73-83
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  • These cases presented as two subsets: low grade malignancy epithelioid hemangioendothelioma (PEH) (12 cases--eight women and four men, aged between 18 and 75 years) and highly malignant endotheliosarcoma seen in two men, 28 and 47 years old.
  • The patients with epithelioid hemangioendothelioma reported to hospitals mainly because routine chest X-ray examinations accidentally revealed nodular lesions involving both lungs.
  • Histological examination of the material collected from the bronchi and sputum was negative for neoplasm.
  • In these cases, the course of the disease was slow and the patients were in a good condition for many years.
  • In one case (a 27-year old woman), the diagnosis was possible after autopsy.
  • Highly malignant endothelial sarcomas were seen in two men with a poor clinical status; one of them died shortly after histological diagnosis had been established based on material taken during a thoracotomy.
  • In the second case, the diagnosis was possible on autopsy The prognosis for patients with these highly malignant tumors is highly unfavorable.
  • [MeSH-major] Hemangioendothelioma / pathology. Hemangioendothelioma, Epithelioid / pathology. Lung Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / analysis. Endothelium, Vascular / chemistry. Endothelium, Vascular / pathology. Female. Humans. Male. Middle Aged

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  • (PMID = 18669172.001).
  • [ISSN] 1233-9687
  • [Journal-full-title] Polish journal of pathology : official journal of the Polish Society of Pathologists
  • [ISO-abbreviation] Pol J Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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85. Türkmen C, Unal S, Sanli Y, Kebudi R: Technetium-99m red blood cell imaging of multicentric kaposiform haemangioendothelioma. Eur J Nucl Med Mol Imaging; 2006 Feb;33(2):232-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Technetium-99m red blood cell imaging of multicentric kaposiform haemangioendothelioma.
  • [MeSH-major] Erythrocytes / pathology. Hemangioendothelioma / pathology. Skin Neoplasms / diagnosis. Soft Tissue Neoplasms / diagnosis. Technetium

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  • [ErratumIn] Eur J Nucl Med Mol Imaging. 2006 Mar;33(3):391
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  • (PMID = 16369838.001).
  • [ISSN] 1619-7070
  • [Journal-full-title] European journal of nuclear medicine and molecular imaging
  • [ISO-abbreviation] Eur. J. Nucl. Med. Mol. Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 7440-26-8 / Technetium
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86. Bhattacharyya NK, Chatterjee U, Sen S, Sarkar S: Infantile hemangioendothelioma of liver: report of two cases. Indian J Pathol Microbiol; 2007 Apr;50(2):340-2
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  • [Title] Infantile hemangioendothelioma of liver: report of two cases.
  • Infantile hemangioendothelioma, the commonest mesenchymal tumour of liver in infancy, though benign in nature, may behave aggressively.
  • [MeSH-major] Hemangioendothelioma / pathology. Liver Neoplasms / pathology

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  • (PMID = 17883065.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Antigens, CD34; 68238-35-7 / Keratins
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87. Deedar-Ali-Khawaja R, Fatimi SH, Shahabuddin S: Epithelioid hemangioendothelioma of axillary vein: an imminent vascular tumor? Am Surg; 2010 Sep;76(9):E176-7
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  • [Title] Epithelioid hemangioendothelioma of axillary vein: an imminent vascular tumor?
  • [MeSH-major] Axillary Vein. Hemangioendothelioma, Epithelioid / pathology. Hemangioendothelioma, Epithelioid / surgery. Soft Tissue Neoplasms / pathology. Vascular Neoplasms / pathology. Vascular Neoplasms / surgery
  • [MeSH-minor] Biopsy, Needle. Diagnosis, Differential. Follow-Up Studies. Humans. Immunohistochemistry. Magnetic Resonance Angiography / methods. Male. Middle Aged. Neoplasm Staging. Thoracotomy / methods. Treatment Outcome

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  • (PMID = 21396278.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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88. Mukhina MS, Maksimova NA, Tarasova MV, Levchenko IuA, Kulakova IuA, Romanchishin AF: [Epitheliod hemangioendothelioma of the lung]. Arkh Patol; 2009 Nov-Dec;71(6):39-41
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  • [Title] [Epitheliod hemangioendothelioma of the lung].
  • The authors give a morphological and immunohistochemical description of epitheliod hemangioendothelioma of the lung in two women aged 62 and 74 years.
  • Evident neovascularization capacity, a significant tumor cell intracytoplasmic lumen frequently packed with red blood cells, and positive immunohistochemical reactions to endothelial antigens are of prime importance in making its diagnosis.
  • [MeSH-major] Hemangioendothelioma, Epithelioid / pathology. Lung Neoplasms / pathology. Neovascularization, Pathologic / pathology

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  • (PMID = 20131506.001).
  • [ISSN] 0004-1955
  • [Journal-full-title] Arkhiv patologii
  • [ISO-abbreviation] Arkh. Patol.
  • [Language] rus
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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89. Cho WS, Kim SK, Park SH, Cho BK: Intracranial kaposiform hemangioendothelioma: proposal of a new malignant variant. J Neurosurg Pediatr; 2009 Feb;3(2):147-50
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  • [Title] Intracranial kaposiform hemangioendothelioma: proposal of a new malignant variant.
  • Kaposiform hemangioendothelioma (KHE) is a rare vascular tumor of infancy and early childhood that occurs mainly in soft tissue and the retroperitoneum.
  • The pathological characteristics of a KHE are fascicles of spindleshaped endothelial cells and slitlike vascular channels with irregular tumor margins.
  • Kaposiform hemangioendothelioma should be considered in the differential diagnosis of intracranial and extraaxial tumors.
  • [MeSH-major] Brain Neoplasms / pathology. Hemangioendothelioma / pathology. Sarcoma, Kaposi / pathology


90. Chen YJ, Wang CK, Tien YC, Hsieh TJ: MRI of multifocal kaposiform haemangioendothelioma without Kasabach-Merritt phenomenon. Br J Radiol; 2009 Mar;82(975):e51-4
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  • [Title] MRI of multifocal kaposiform haemangioendothelioma without Kasabach-Merritt phenomenon.
  • Kaposiform haemangioendothelioma is a rare soft-tissue tumour of infants and children, and presents as a moderately aggressive malignancy.
  • We present the MRI findings of a histologically proven case of Kaposiform haemangioendothelioma without Kasabach-Merritt phenomenon or typical skin changes.
  • [MeSH-major] Hemangioendothelioma / pathology. Pain / etiology. Skin / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Biopsy. Child. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male. Treatment Outcome

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  • (PMID = 19211904.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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91. Pires I, Queiroga FL, Silva F, Pinto C, Lopes C: Kaposi-like vascular tumor of the urinary bladder in a cow. J Vet Med Sci; 2009 Jun;71(6):831-3
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  • [Title] Kaposi-like vascular tumor of the urinary bladder in a cow.
  • Kaposiform hemangioendothelioma is a rare human vascular neoplasm.
  • Peripherically, well-formed vascular channels were seen.
  • Based on its characteristics, it was classified as kaposiform hemangioendothelioma and as far as we know, it is the first case described in cattle.

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  • (PMID = 19578299.001).
  • [ISSN] 0916-7250
  • [Journal-full-title] The Journal of veterinary medical science
  • [ISO-abbreviation] J. Vet. Med. Sci.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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92. Roomi MW, Kalinovsky T, Niedzwiecki A, Rath M: Antiangiogenic properties of a nutrient mixture in a model of hemangioma. Exp Oncol; 2009 Dec;31(4):214-9
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  • AIM: Using a mouse hemangioendothelioma model, we investigated the efficacy of NM.
  • CONCLUSIONS: These results suggest that NM may have therapeutic potential in treating infantile hemangioendotheliomas and, perhaps, other cutaneous vascular tumors.
  • [MeSH-major] Angiogenesis Inhibitors / pharmacology. Hemangioendothelioma / drug therapy. Phytotherapy / methods

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  • Hazardous Substances Data Bank. Sodium ascorbate .
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  • (PMID = 20010532.001).
  • [ISSN] 1812-9269
  • [Journal-full-title] Experimental oncology
  • [ISO-abbreviation] Exp. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ukraine
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Plant Extracts; 9DLQ4CIU6V / Proline; K3Z4F929H6 / Lysine; PQ6CK8PD0R / Ascorbic Acid
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93. Alomari AI: The lollipop sign: a new cross-sectional sign of hepatic epithelioid hemangioendothelioma. Eur J Radiol; 2006 Sep;59(3):460-4
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  • [Title] The lollipop sign: a new cross-sectional sign of hepatic epithelioid hemangioendothelioma.
  • In four cases of hepatic epithelioid hemangioendothelioma (HEHE), multiple liver lesions were depicted on enhanced computed tomography (CT) and/or magnetic resonance imaging (MRI) scans.
  • [MeSH-major] Hemangioendothelioma, Epithelioid / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Tomography, X-Ray Computed

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  • (PMID = 16644166.001).
  • [ISSN] 0720-048X
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Ireland
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94. Mosoia L, Mabrut JY, Adham M, Boillot O, Ducerf C, Partensky C, Baulieux J: Hepatic epithelioid hemangioendothelioma: long-term results of surgical management. J Surg Oncol; 2008 Nov 1;98(6):432-7
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  • [Title] Hepatic epithelioid hemangioendothelioma: long-term results of surgical management.
  • BACKGROUND AND OBJECTIVES: Hepatic epithelioid hemangioendothelioma (HEHE) is a rare vascular neoplasm of the liver.
  • Intrahepatic disease extent was monolobar and bilobar in two and seven patients, respectively.
  • At the time of the follow-up, seven out of the nine patients treated (two after LR, and five after LT) were alive and disease-free.
  • CONCLUSIONS: Surgical treatment offers good long-term results in patients suffering from HEHE when LR is tailored to the intrahepatic disease extent: LT has to be considered in patients with bilobar intrahepatic disease whereas LR should be strictly limited to patients presenting with localized and monolobar intrahepatic disease.
  • [MeSH-major] Hemangioendothelioma, Epithelioid / mortality. Hemangioendothelioma, Epithelioid / surgery. Liver Neoplasms / mortality. Liver Neoplasms / surgery
  • [MeSH-minor] Adult. Disease-Free Survival. Female. Follow-Up Studies. Hepatectomy. Humans. Liver Function Tests. Liver Transplantation. Male. Middle Aged. Neoplasm Recurrence, Local / surgery. Postoperative Complications. Retrospective Studies. Treatment Outcome

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 18792957.001).
  • [ISSN] 1096-9098
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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95. Dhillon MS, Rai JK, Gunson BK, Olliff S, Olliff J: Post-transplant lymphoproliferative disease in liver transplantation. Br J Radiol; 2007 May;80(953):337-46
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  • [Title] Post-transplant lymphoproliferative disease in liver transplantation.
  • Post-transplant lymphoproliferative disease (PTLD) is a well recognized complication of solid organ transplantation and therapeutic immunosuppression, first reported in 1968.
  • Indication for transplant ranged from primary biliary cirrhosis (eight patients) to epitheloid haemangioendothelioma (one patient).
  • The average time interval between transplant and diagnosis of PTLD was 50 months.
  • Imaging abnormalities identified included generalized lymphadenopathy, liver and portal masses, splenic enlargement, bowel, eye, cerebral and neck involvement; and in two patients, no radiological abnormality.


96. Sun ZJ, Zhang L, Zhang WF, Chen XM, Lai FM, Zhao YF: Epithelioid hemangioendothelioma of the oral cavity. Oral Dis; 2007 Mar;13(2):244-50
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  • [Title] Epithelioid hemangioendothelioma of the oral cavity.
  • OBJECTIVE: To investigate the clinicopathological characteristics and biologic behaviour of epithelioid hemangioendothelioma in the oral cavity.
  • MATERIALS AND METHODS: The clinical features and pathological findings of nine cases with intraoral epithelioid hemangioendothelioma were reviewed, including immunohistochemistry study.
  • CONCLUSIONS: Wide local excision with long-term follow-up seems to be the treatment of choice for intraoral epithelioid hemangioendothelioma because of their unpredictable biological behaviour and recurrence potential.
  • [MeSH-major] Hemangioendothelioma, Epithelioid / pathology. Mouth Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Antigens, CD34 / analysis. Child. Female. Gingival Neoplasms / pathology. Herpesvirus 8, Human / isolation & purification. Humans. Keratins / analysis. Lip Neoplasms / pathology. Male. Mandibular Neoplasms / pathology. Maxillary Neoplasms / pathology. Middle Aged. Mouth Floor / pathology. Mouth Mucosa / pathology. Mucin-1 / analysis. Neoplasm Recurrence, Local / pathology. Retrospective Studies. S100 Proteins / analysis. Tongue Neoplasms / pathology. Vimentin / analysis. von Willebrand Factor / analysis

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  • (PMID = 17305630.001).
  • [ISSN] 1354-523X
  • [Journal-full-title] Oral diseases
  • [ISO-abbreviation] Oral Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Mucin-1; 0 / S100 Proteins; 0 / Vimentin; 0 / von Willebrand Factor; 68238-35-7 / Keratins
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97. Bruegel M, Waldt S, Weirich G, Woertler K, Rummeny EJ: Multifocal epithelioid hemangioendothelioma of the phalanges of the hand. Skeletal Radiol; 2006 Oct;35(10):787-92
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  • [Title] Multifocal epithelioid hemangioendothelioma of the phalanges of the hand.
  • Epithelioid hemangioendothelioma (EH) of bone is a rare vascular neoplasm characterized by epithelioid endothelial cells and a variable biologic behaviour.
  • Approximately half of the cases present with multifocal disease.
  • The latter feature can be helpful in suggesting the diagnosis of a vascular tumor; on the other hand, it strengthens the need for a skeletal survey or whole-body MRI/CT.
  • We report on the clinical, histologic and radiologic features-including CT and MRI findings-of EH in a case of multifocal disease of the phalanges of the hand, a very uncommon anatomic site of affliction.
  • [MeSH-major] Bone Neoplasms / diagnosis. Finger Phalanges / pathology. Hemangioendothelioma, Epithelioid / diagnosis

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  • (PMID = 16132980.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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98. Yoruk O, Erdem H, Mutlu V, Erdogan F, Altas E, Kantarci M: Epithelioid hemangioendothelioma of the submandibular gland. Auris Nasus Larynx; 2008 Mar;35(1):157-9
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  • [Title] Epithelioid hemangioendothelioma of the submandibular gland.
  • Epithelioid hemangioendothelioma (EH) is a seldom tumor of vascular origin, which occurs at sites such as liver, lung or soft tissues, and has a highly unpredictable malignant potential and clinical course.
  • We submitted a case with epithelioid hemangioendothelioma of submandibular gland.
  • The pathological result was interpretated as epithelioid hemangioendothelioma of the submandibular gland.
  • [MeSH-major] Hemangioendothelioma, Epithelioid / diagnosis. Submandibular Gland Neoplasms / diagnosis
  • [MeSH-minor] Adult. Biopsy, Fine-Needle. Calcinosis / diagnosis. Calcinosis / pathology. Calcinosis / surgery. Female. Humans. Submandibular Gland / pathology. Submandibular Gland / surgery. Tomography, X-Ray Computed

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  • (PMID = 17884320.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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99. Berber E, Ari E, Herceg N, Siperstein A: Laparoscopic radiofrequency thermal ablation for unusual hepatic tumors: operative indications and outcomes. Surg Endosc; 2005 Dec;19(12):1613-7
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  • Little is known about the outcomes for patients with other tumor types.
  • Among these, 53 patients (10%) had cancers other than the colorectal, neuroendocrine, or hepatocellular types including sarcoma (n = 18), breast cancer (n = 10), esophagus cancer (n = 4), melanoma (n = 4), lung cancer (n = 3), ovarian cancer (n = 2), pancreas cancer (n = 2), unknown primary cancer (n = 2), cholangiocarcinoma (n = 2), rectal squamous cancer (n = 2), renal cancer (n = 2), papillary thyroid cancer (n = 1), and hemangioendothelioma (n = 1).
  • Unlike the criteria for treatment of the more usual tumor types, these patients had a diagnosis of liver-exclusive disease, as diagnosed by preoperative imaging.
  • CONCLUSION: Laparoscopic radiofrequency ablation can safely and effectively treat hepatic metastasis of these unusual tumor types.
  • The authors believe that this heterogeneous group of patients, selected for their unusual presentation of liver-exclusive disease, may benefit from cytoreduction of their tumor by laparoscopic radiofrequency ablation when other treatment methods have failed.

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  • (PMID = 16247574.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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100. Arai E, Kuramochi A, Tsuchida T, Tsuneyoshi M, Kage M, Fukunaga M, Ito T, Tada T, Izumi M, Shimizu K, Hirose T, Shimizu M: Usefulness of D2-40 immunohistochemistry for differentiation between kaposiform hemangioendothelioma and tufted angioma. J Cutan Pathol; 2006 Jul;33(7):492-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Usefulness of D2-40 immunohistochemistry for differentiation between kaposiform hemangioendothelioma and tufted angioma.
  • Our objective was to elucidate, using D2-40 immunohistochemistry, the differences among capillary hemangiomas, and especially between kaposiform hemangioendothelioma (KHE) and tufted angioma (TA).
  • We studied four cases of KHE, nine cases of TA, and 31 cases of other vascular tumors.
  • Namely, they may originate from stem cells possessing the characteristics of both lymphatic and blood vessel endothelial lineages.
  • [MeSH-major] Antibodies, Monoclonal / immunology. Biomarkers, Tumor / immunology. Hemangioendothelioma / diagnosis. Hemangioma / diagnosis. Sarcoma, Kaposi / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Antibodies, Monoclonal, Murine-Derived. Capillaries. Diagnosis, Differential. Humans. Immunohistochemistry. Retrospective Studies






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