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1. Barrionuevo C, Zaharia M, Martinez MT, Taxa L, Misad O, Moscol A, Sarria G, Guerrero I, Casanova L, Flores C, Zevallos-Giampietri EA: Extranodal NK/T-cell lymphoma, nasal type: study of clinicopathologic and prognosis factors in a series of 78 cases from Peru. Appl Immunohistochem Mol Morphol; 2007 Mar;15(1):38-44
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  • [Title] Extranodal NK/T-cell lymphoma, nasal type: study of clinicopathologic and prognosis factors in a series of 78 cases from Peru.
  • It is well known that extranodal NK/T-cell lymphoma (NK/TCL) nasal type clusters in Asian countries.
  • A large series of 78 cases of nasal NK/TCL from Peru is analyzed in the present study.
  • Except for nasal obstruction, more common in group 2, all other symptoms were similar in both groups.
  • In this series type-2 EBV was found more frequent than type-1 EBV, contrarily to that observed in Asian series.
  • The present study has shown that dividing nasal NK/TCL in monomorphic and polymorphic variants, according to frequency of large cells, does not correlate with clinical and prognostic factors.

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  • (PMID = 17536305.001).
  • [ISSN] 1541-2016
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
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2. Zhang WY, Li GD, Liu WP, Ouyang Q, Ren XC, Li FY, Xu H: Features of intestinal T-cell lymphomas in Chinese population without evidence of celiac disease and their close association with Epstein-Barr virus infection. Chin Med J (Engl); 2005 Sep 20;118(18):1542-8
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  • [Title] Features of intestinal T-cell lymphomas in Chinese population without evidence of celiac disease and their close association with Epstein-Barr virus infection.
  • BACKGROUND: Intestinal T-cell lymphoma (ITCL) is a heterogeneous lymphoid neoplastic group with variable clinical and pathological features.
  • ITCL in oriental countries is different from enteropathy-type intestinal T-cell lymphoma (ETCL) in relation to celiac disease and Epstein-Barr virus (EBV).
  • The objective of this study was to investigate the clinicopathological features, immunophenotype, expression of cytotoxic molecule (TIA-1), T-cell receptor (TCR)-gamma gene rearrangement, and Epstein-Barr virus (EBV) latent infection in primary ITCL without celiac disease in Chinese.
  • Neoplastic cells partially expressed T-cell differentiated antigens (CD3epsilon, CD4, CD8) and NK cell associated antigen (CD56).
  • A small proportion of primary ITCLs in Chinese and extranodal NK/T-cell lymphoma of nasal type belong to the same spectrum.
  • [MeSH-major] Epstein-Barr Virus Infections / complications. Intestinal Neoplasms / pathology. Lymphoma, T-Cell / pathology
  • [MeSH-minor] Adolescent. Adult. Celiac Disease / complications. Child. Female. Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor. Humans. Immunophenotyping. In Situ Hybridization. Male. Middle Aged. RNA, Viral / genetics. Viral Matrix Proteins / genetics

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  • (PMID = 16232331.001).
  • [ISSN] 0366-6999
  • [Journal-full-title] Chinese medical journal
  • [ISO-abbreviation] Chin. Med. J.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / EBV-associated membrane antigen, Epstein-Barr virus; 0 / Epstein-Barr virus encoded RNA 1; 0 / Epstein-Barr virus encoded RNA 2; 0 / RNA, Viral; 0 / Viral Matrix Proteins
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3. Ishida F, Nishina S, Asano N, Sasaki S, Sekiguchi N, Nakazawa H, Ito T, Shikama N: Late relapse of extranodal natural killer/T cell lymphoma, nasal type, after more than ten years. Leuk Lymphoma; 2010 Jan;51(1):171-3
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  • [Title] Late relapse of extranodal natural killer/T cell lymphoma, nasal type, after more than ten years.
  • [MeSH-major] Killer Cells, Natural / pathology. Lymphoma, T-Cell / diagnosis. Nose Neoplasms / diagnosis

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  • (PMID = 19886846.001).
  • [ISSN] 1029-2403
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
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4. Kim SJ, Kim K, Kim BS, Kim CY, Suh C, Huh J, Lee SW, Kim JS, Cho J, Lee GW, Kang KM, Eom HS, Pyo HR, Ahn YC, Ko YH, Kim WS: Phase II trial of concurrent radiation and weekly cisplatin followed by VIPD chemotherapy in newly diagnosed, stage IE to IIE, nasal, extranodal NK/T-Cell Lymphoma: Consortium for Improving Survival of Lymphoma study. J Clin Oncol; 2009 Dec 10;27(35):6027-32
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  • [Title] Phase II trial of concurrent radiation and weekly cisplatin followed by VIPD chemotherapy in newly diagnosed, stage IE to IIE, nasal, extranodal NK/T-Cell Lymphoma: Consortium for Improving Survival of Lymphoma study.
  • PURPOSE: On the basis of the benefits of frontline radiation in early-stage, extranodal, natural killer (NK)/T-cell lymphoma (ENKTL), we conducted a phase II trial of concurrent chemoradiotherapy (CCRT) followed by three cycles of etoposide, ifosfamide, cisplatin, and dexamethasone (VIPD).
  • PATIENTS AND METHODS: Thirty patients with newly diagnosed, stages IE to IIE, nasal ENKTL received CCRT (ie radiation 40 to 52.8 Gy and cisplatin 30 mg/m(2) weekly).
  • CONCLUSION: Patients with newly diagnosed, stages IE to IIE, nasal ENKTL are best treated with frontline CCRT.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Lymphoma, Extranodal NK-T-Cell / drug therapy. Lymphoma, Extranodal NK-T-Cell / radiotherapy. Nose Neoplasms / drug therapy. Nose Neoplasms / radiotherapy

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  • [CommentIn] J Clin Oncol. 2010 May 10;28(14):e229; author reply e230 [20351319.001]
  • (PMID = 19884539.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 6PLQ3CP4P3 / Etoposide; 7S5I7G3JQL / Dexamethasone; Q20Q21Q62J / Cisplatin; UM20QQM95Y / Ifosfamide
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5. Kim TM, Lee SY, Jeon YK, Ryoo BY, Cho GJ, Hong YS, Kim HJ, Kim SY, Kim CS, Kim S, Kim JS, Sohn SK, Song HH, Lee JL, Kang YK, Yim CY, Lee WS, Yuh YJ, Kim CW, Heo DS, Lymphoma Subcommittee of the Korean Cancer Study Group: Clinical heterogeneity of extranodal NK/T-cell lymphoma, nasal type: a national survey of the Korean Cancer Study Group. Ann Oncol; 2008 Aug;19(8):1477-84
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  • [Title] Clinical heterogeneity of extranodal NK/T-cell lymphoma, nasal type: a national survey of the Korean Cancer Study Group.
  • BACKGROUND: This national survey was undertaken to propose the classification of extranodal natural killer (NK)/T-cell lymphoma (NTCL) subtypes and to clarify a clinical heterogeneity.
  • In the NUAT subset, extranodal sites and regional nodes predicted the OS, while Ann Arbor staging, age, performance status, and lactate dehydrogenase level predicted the OS in the UAT subset.

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  • (PMID = 18385201.001).
  • [ISSN] 1569-8041
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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6. Briese J, Noack F, Harland A, Horny HP: Primary extranodal NK/T cell lymphoma ("nasal type") of the endometrium: report of an unusual case diagnosed at autopsy. Gynecol Obstet Invest; 2006;61(3):164-6
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  • [Title] Primary extranodal NK/T cell lymphoma ("nasal type") of the endometrium: report of an unusual case diagnosed at autopsy.
  • Primary natural killer (NK)/T cell lymphoma of the female genital tract is extremely rare.
  • We here report the case of a "nasal type" NK/T cell lymphoma arising in the uterus.
  • The diagnosis was established only at autopsy.
  • [MeSH-major] Endometrial Neoplasms / pathology. Killer Cells, Natural / pathology. Lymphoma, T-Cell / pathology

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  • [Copyright] Copyright (c) 2006 S. Karger AG, Basel.
  • (PMID = 16424671.001).
  • [ISSN] 0378-7346
  • [Journal-full-title] Gynecologic and obstetric investigation
  • [ISO-abbreviation] Gynecol. Obstet. Invest.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Antigens, Differentiation, T-Lymphocyte; 0 / Biomarkers, Tumor
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7. Kako S, Izutsu K, Ota Y, Minatani Y, Sugaya M, Momose T, Ohtomo K, Kanda Y, Chiba S, Motokura T, Kurokawa M: FDG-PET in T-cell and NK-cell neoplasms. Ann Oncol; 2007 Oct;18(10):1685-90
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  • [Title] FDG-PET in T-cell and NK-cell neoplasms.
  • BACKGROUND: A growing number of studies demonstrate the utility of (18)fluoro-2-deoxyglucose positron emission tomography (FDG-PET) in the management of malignant lymphoma.
  • The results of FDG-PET, however, have not been studied extensively for T-cell and natural killer (NK)-cell neoplasms.
  • PATIENTS AND METHODS: We retrospectively evaluated pretreatment FDG-PET scans in 41 patients with T/NK-cell neoplasms diagnosed according to the World Health Organization (WHO) classification.
  • Histological subtypes frequently included were peripheral T-cell lymphoma, unspecified (PTCLu, n = 11), extranodal NK/T-cell lymphoma, nasal type (ENKL, n = 8), primary cutaneous anaplastic large cell lymphoma (C-ALCL, n = 5), and angioimmunoblastic T-cell lymphoma (AILT, n = 4).
  • RESULTS: FDG-PET detected a lymphoma lesion in at least one site in 36 out of 41 patients.
  • The positive rate was equally high in most histological subtypes except for cutaneous lymphomas: PTCLu 91%, ENKL 100%, C-ALCL 60%, AILT 100%.
  • CONCLUSION: T/NK-cell neoplasms incorporated in this study were generally FDG-avid except for cutaneous lesions and bone marrow involvement.

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  • (PMID = 17716987.001).
  • [ISSN] 1569-8041
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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8. Tai WC, Li HP, Lin TY, Lin CY, Wu MT: Response of extranodal natural killer/T-cell lymphoma, nasal type, to interferon-alpha, corticosteroid and narrowband ultraviolet B phototherapy. Clin Exp Dermatol; 2009 Dec;34(8):e927-30
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  • [Title] Response of extranodal natural killer/T-cell lymphoma, nasal type, to interferon-alpha, corticosteroid and narrowband ultraviolet B phototherapy.
  • Extranodal natural killer (NK)/T-cell lymphoma, nasal type (ENKTLN), is characterized by higher prevalence in East Asians and South Americans, association with Epstein-Barr virus infection, aggressive nature in most cases, and resistance to conventional treatment strategies such as chemotherapy and radiotherapy.
  • [MeSH-major] Interferon-alpha / administration & dosage. Lymphoma, T-Cell / therapy. Nose Neoplasms / therapy
  • [MeSH-minor] Combined Modality Therapy. Female. Humans. Middle Aged. Natural Killer T-Cells / pathology. Phototherapy. Treatment Outcome

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  • (PMID = 20055869.001).
  • [ISSN] 1365-2230
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Interferon-alpha
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9. He YJ, Jia XS, Hasui K, Wang EH, He AG: [Nasal and pharyngeal non-Hodgkin lymphomas and their relationship with Epstein-Barr virus: a report of 158 cases]. Zhonghua Bing Li Xue Za Zhi; 2007 Feb;36(2):94-7
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  • [Title] [Nasal and pharyngeal non-Hodgkin lymphomas and their relationship with Epstein-Barr virus: a report of 158 cases].
  • OBJECTIVE: To study the clinical features, immunophenotypes and the significance of Epstein-Barr virus infection in primary nasal and pharyngeal non-Hodgkin's lymphomas in Shenyang.
  • METHODS: One hundred and fifty eight cases of primary nasal and pharyngeal non-Hodgkin's lymphomas were included in this study.
  • Immunohistochemistry studies were performed using monoclonal antibodies, including CD3 for T-lymphocytes, CD20 for B-lymphocytes, and CD56 and CD57 for NK cells.
  • All cases were reclassified according to the new WHO classification of lymphomas (2001).
  • RESULTS: Overall, 101 (63.9%) of the 158 NHL were extranodal NK/T cell lymphomas (nasal type), 23 (14.6%) were nonspecific peripheral T cell lymphomas and the remaining 34 cases (21.5%) were B cell lymphomas.
  • The primary sites of involvement were the nasal cavity (53.2%, 84/158), the tonsil (24.7%, 39/158) and the pharynx (22.1%, 35/158).
  • Among 99 cases studied by EBER-1 in situ hybridization, a positive detection was seen in 70/71 cases (98.6%) of extranodal NK/T cell lymphoma (nasal type), 8/12 cases (66.7%) of T cell lymphoma, and 7/16 cases (43.8%) of B cell lymphoma.
  • CONCLUSIONS: Among primary nasal and pharyngeal NK lymphomas, extranodal NK/T cell lymphoma (nasal type) is the most common type and is strongly associated with EBV infection.
  • The pathological diagnosis of nasal and pharyngeal lymphomas should take considerations of the anatomic sites and immunophenotypical features.
  • [MeSH-major] Herpesvirus 4, Human / isolation & purification. Lymphoma, Non-Hodgkin. Nasal Cavity. Nose Neoplasms. Pharyngeal Neoplasms
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Antigens, CD3 / metabolism. Antigens, CD56 / metabolism. Child. Female. Humans. Lymphoma, B-Cell / metabolism. Lymphoma, B-Cell / pathology. Lymphoma, B-Cell / virology. Lymphoma, Extranodal NK-T-Cell / metabolism. Lymphoma, Extranodal NK-T-Cell / pathology. Lymphoma, Extranodal NK-T-Cell / virology. Lymphoma, T-Cell, Peripheral / metabolism. Lymphoma, T-Cell, Peripheral / pathology. Lymphoma, T-Cell, Peripheral / virology. Male. Middle Aged. RNA, Viral / metabolism. Tonsillar Neoplasms / metabolism. Tonsillar Neoplasms / pathology. Tonsillar Neoplasms / virology. Young Adult

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  • (PMID = 17493382.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD3; 0 / Antigens, CD56; 0 / Epstein-Barr virus encoded RNA 1; 0 / RNA, Viral
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10. Zhang S, Nong L, Zhang Y, Wang Y, Li T: [Expression of natural killer cell development-associated transcription factors in nasal NK/T-cell lymphomas occurring in Chinese population]. Zhonghua Bing Li Xue Za Zhi; 2010 Jun;39(6):366-71
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  • [Title] [Expression of natural killer cell development-associated transcription factors in nasal NK/T-cell lymphomas occurring in Chinese population].
  • OBJECTIVE: To evaluate the expression and prognostic significance of T-bet and its cofactors EOMES, ETS-1 and MEF [which are transcription factors and responsible for development of natural killer (NK) cells] in the extranodal NK/T-cell lymphoma, nasal type (EN-NK/T-NT).
  • METHODS: The expression status of T-bet, EOMES, ETS-1 and MEF in 40 cases of EN-NK/T-NT occurring in Chinese population was studied by immunohistochemistry and in-situ hybridization (ISH).
  • The control cases included 18 cases of peripheral T-cell lymphoma, 10 cases of B-cell lymphoma, 5 cases of normal spleen, 5 cases of normal thymus and 10 cases of nasal mucosal tissues affected by chronic inflammation.
  • RESULTS: The expression levels of T-bet mRNA and protein were high in EN-NK/T-NT (82.5% and 100%, respectively) and in peripheral T cell lymphoma (17/18 and 72.2%, respectively).
  • There was no expression in B-cell lymphoma.
  • The expression of EOMES (80.0% by ISH), ETS-1 (82.5% by ISH) and MEF (62.5% by ISH) was high in EN-NK/T-NT, but not in the control group.
  • Follow-up study showed that the mean and median survival of the 19 cases of EN-NK/ T-NT was 33 months and 10 months, respectively.
  • CONCLUSIONS: The expression of T-bet correlates with the lymphoma types.
  • It is mainly expressed in peripheral NK and T-cell lymphomas.
  • The important functional gene engaged in NK cells development is highly expressed in EN-NK/T-NT.
  • [MeSH-minor] Adolescent. Adult. Aged. China / epidemiology. Female. Follow-Up Studies. Humans. Lymphoma, Extranodal NK-T-Cell. Lymphoma, T-Cell, Peripheral / metabolism. Male. Middle Aged. RNA, Messenger / metabolism. Survival Rate. Young Adult

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  • (PMID = 21055151.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / ELF4 protein, human; 0 / EOMES protein, human; 0 / Proto-Oncogene Protein c-ets-1; 0 / RNA, Messenger; 0 / T-Box Domain Proteins; 0 / T-box transcription factor TBX21; 0 / Transcription Factors
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11. Massone C, Lozzi GP, Egberts F, Fink-Puches R, Cota C, Kerl H, Cerroni L: The protean spectrum of non-Hodgkin lymphomas with prominent involvement of subcutaneous fat. J Cutan Pathol; 2006 Jun;33(6):418-25
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  • [Title] The protean spectrum of non-Hodgkin lymphomas with prominent involvement of subcutaneous fat.
  • BACKGROUND: Subcutaneous T-cell lymphoma (STCL) represents a controversial entity and a confused concept in the field of cutaneous T-cell lymphomas (CTCLs).
  • Recently, alpha/beta+/CD8+ STCL has been recognized by the new World Health Organization (WHO)-European Organization for Research and Treatment of Cancer (EORTC) classification of primary cutaneous lymphomas as a distinct entity in the group of CTCLs.
  • OBSERVATIONS: We reviewed a series of 53 biopsies from 26 patients (F : M = 19:7; median age: 48; range 18-87) of cutaneous B- and T-cell lymphomas characterized by prominent involvement of the subcutaneous tissue.
  • (ii) extranodal NK/T-cell lymphoma, nasal type: n = 2;.
  • (iii) cutaneous gamma/delta T-cell lymphoma: n = 2;.
  • (iv) anaplastic CD30+ large T-cell lymphoma: n = 1;.
  • (v) diffuse large B-cell lymphoma, secondary cutaneous: n = 3;.
  • (vi) lymphoplasmacytic lymphoma, secondary cutaneous: n = 1;.
  • CONCLUSIONS: We demonstrated the protean nature of lymphomas with prominent involvement of the subcutaneous fat tissues.
  • [MeSH-major] Adipose Tissue / pathology. Lymphoma, T-Cell, Cutaneous / pathology. Skin Neoplasms / pathology. Subcutaneous Tissue / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Biopsy. Female. Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor. Humans. Immunoenzyme Techniques. Immunophenotyping. Male. Middle Aged. Polymerase Chain Reaction / methods

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  • (PMID = 16776717.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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12. Cho HI, Hong YS, Lee MA, Kim EK, Yoon SH, Kim CC, Kim TG: Adoptive transfer of Epstein-Barr virus-specific cytotoxic T-lymphocytes for the treatment of angiocentric lymphomas. Int J Hematol; 2006 Jan;83(1):66-73
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  • [Title] Adoptive transfer of Epstein-Barr virus-specific cytotoxic T-lymphocytes for the treatment of angiocentric lymphomas.
  • Angiocentric lymphoma, known as natural killer (NK)/T-cell non-Hodgkin's lymphoma, has been reported to be associated with the Epstein-Barr virus (EBV).
  • We performed adoptive transfer of EBV-specific polyclonal T-cell lines in 3 patients with extranodal NK/T-cell lymphoma, nasal type, and evaluated the treatment for safety, immunologic reconstitution, and clinical outcomes.
  • In the cases of the first and second patients, EBV-transformed B-lymphoblastoid cell lines (LCLs) and T-cell lines were generated from peripheral lymphocytes of HLA-matched sibling donors.
  • The third patient's T-cell lines were induced with autologous lymphocytes.
  • Polyclonal T-cell infusion was carried out after high-dose radiotherapy because active relapsed disease remained in all of the patients.
  • All T-cell lines showed >60% NK activity, cytotoxic T-lymphocyte (CTL) responses of >40% against autologous LCLs, and no CTL activity against patient-derived lymphoblasts.
  • The level of cytotoxicity increased substantially in all patients after cell infusion.
  • The 2 patients who received T-cell therapy twice had stabilized disease for more than 3 years.
  • These safe treatments exhibited no severe inflammatory response, and no serious toxicity developed during T-cell therapy.
  • Our findings demonstrate that adoptively transferred cells may provide reconstitution of EBV-specific CTL responses in patients with active relapsed angiocentric lymphoma.
  • These results provide a rationale for the immunotherapy of angiocentric lymphoma.
  • [MeSH-major] Epstein-Barr Virus Infections / therapy. Immunotherapy, Adoptive. Lymphoma, Non-Hodgkin / therapy. Nose Neoplasms / therapy. T-Lymphocytes, Cytotoxic / transplantation
  • [MeSH-minor] Adult. Cell Line. Disease-Free Survival. Herpesvirus 4, Human. Humans. Killer Cells, Natural / pathology. Killer Cells, Natural / virology. Male. Treatment Outcome

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  • (PMID = 16443556.001).
  • [ISSN] 0925-5710
  • [Journal-full-title] International journal of hematology
  • [ISO-abbreviation] Int. J. Hematol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
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13. Kobayashi R, Yamato K, Tanaka F, Takashima Y, Inada H, Kikuchi A, Kumagai MA, Sunami S, Nakagawa A, Fukano R, Fujita N, Mitsui T, Tsurusawa M, Mori T, Lymphoma Committee, Japanese Pediatric Leukemia/Lymphoma Study Group: Retrospective analysis of non-anaplastic peripheral T-cell lymphoma in pediatric patients in Japan. Pediatr Blood Cancer; 2010 Feb;54(2):212-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Retrospective analysis of non-anaplastic peripheral T-cell lymphoma in pediatric patients in Japan.
  • BACKGROUND: Reports of non-anaplastic peripheral T-cell lymphoma (PTCL) in pediatric patients are relatively rare.
  • There were nine patients with PTCL, not otherwise specified (PTCL-NOS); ten with extranodal NK/T-cell lymphoma, nasal type; one with angioimmunoblastic T-cell lymphoma; and one with subcutaneous panniculitis-like T-cell lymphoma.
  • [MeSH-major] Lymphoma, T-Cell, Peripheral / epidemiology. Lymphoma, T-Cell, Peripheral / therapy
  • [MeSH-minor] Adolescent. Antineoplastic Combined Chemotherapy Protocols. Child. Child, Preschool. Combined Modality Therapy. Female. Humans. Infant. Japan / epidemiology. Male. Retrospective Studies. Stem Cell Transplantation. Survival Rate. Young Adult

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • (PMID = 19856396.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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14. Pol-Rodriguez MM, Fox LP, Sulis ML, Miller IJ, Garzon MC: Extranodal nasal-type natural killer T-cell lymphoma in an adolescent from Bangladesh. J Am Acad Dermatol; 2006 May;54(5 Suppl):S192-7
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  • [Title] Extranodal nasal-type natural killer T-cell lymphoma in an adolescent from Bangladesh.
  • Natural killer (NK)-cell neoplasms are relatively uncommon tumors.
  • Advances in immunohematology over the past 10 years have aided in the recognition and categorization of NK-cell tumors.
  • One type of tumor that belongs to this class is extranodal, nasal-type NK/T-cell lymphoma.
  • These lymphoma cells express a cytotoxic T-cell or NK-cell phenotype, including CD56 and TIA-1.
  • Nasal-type NK/T-cell lymphomas arise from extranasal sites such as the skin and are often associated with Epstein-Barr virus infection.
  • We report a case of an adolescent Bangladeshi boy with extranodal, nasal-type NK/T-cell lymphoma who had cutaneous nodules on the extremities.
  • [MeSH-major] Extremities. Killer Cells, Natural / pathology. Lymphoma, T-Cell / pathology. Skin Neoplasms / pathology

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  • (PMID = 16631938.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD
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15. Tang QL, Liu WP, Zhang WY, Yang F, He MX, Xia QJ, Li GD: [Expression of CYR61 and VEGF in extranodal nasal-type NK/T cell lymphoma and their significances]. Zhonghua Xue Ye Xue Za Zhi; 2006 Oct;27(10):661-5
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  • [Title] [Expression of CYR61 and VEGF in extranodal nasal-type NK/T cell lymphoma and their significances].
  • OBJECTIVE: To investigate the expression of CYR61 and VEGF in extranodal nasal-type NK/T cell lymphoma and its significance.
  • METHODS: CYR61 mRNA and VEGF mRNA were detected by real-time fluorescence quantitative PCR method in 20 cases of extranodal nasal-type NK/T cell lymphoma.
  • CONCLUSION: In extranodal nasal-type NK/T cell lymphoma, the expression level of CYR61 and VEGF was changed and it may be of prognostic implication of
  • [MeSH-major] Immediate-Early Proteins / biosynthesis. Intercellular Signaling Peptides and Proteins / biosynthesis. Lymphoma, T-Cell / metabolism. Nose Neoplasms / metabolism. Vascular Endothelial Growth Factor A / biosynthesis
  • [MeSH-minor] Adolescent. Adult. Aged. Cysteine-Rich Protein 61. Female. Humans. Killer Cells, Natural. Male. Middle Aged. Polymerase Chain Reaction. RNA, Messenger / biosynthesis

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  • (PMID = 17343196.001).
  • [ISSN] 0253-2727
  • [Journal-full-title] Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
  • [ISO-abbreviation] Zhonghua Xue Ye Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / CYR61 protein, human; 0 / Cysteine-Rich Protein 61; 0 / Immediate-Early Proteins; 0 / Intercellular Signaling Peptides and Proteins; 0 / RNA, Messenger; 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A
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16. Zheng YY, Chen G, Zhou XG, Zhang SH, Zhang YN: [Morphologic and immunophenotypic analysis of angioimmunoblastic T-cell lymphoma]. Zhonghua Bing Li Xue Za Zhi; 2009 Mar;38(3):173-7
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  • [Title] [Morphologic and immunophenotypic analysis of angioimmunoblastic T-cell lymphoma].
  • OBJECTIVE: To study the morphologic and immunophenotypic features of angioimmunoblastic T-cell lymphoma (AITL), as well as the origin of the proliferative follicular dendritic cells (FDCs) in AITL.
  • Cases of peripheral T-cell lymphoma, unspecified, extranodal NK/T-cell lymphoma, nasal-type, enteropathy-type T-cell lymphoma, anaplastic large cell lymphoma, subcutaneous panniculitis-like T-cell lymphoma and reactive lymphoid proliferation were selected as controls.
  • RESULTS: Amongst the 29 cases of AITL studied, 75.9% (22/29) showed aberrant expression of CD10, while all except one of the controlled cases were negative, 82.8% (24/29) of the AITL cases expressed CXCL13, while all cases of peripheral T-cell lymphoma, unspecified were negative.
  • As for bcl-6 staining, although the highest percentage of bcl-6-positive cells was observed in AITL, the expression pattern was not useful in differentiating AITL from peripheral T-cell lymphoma, unspecified and lymphoid reaction.
  • Two of the cases, which contained obvious germinal centers, had the follicular dendritic cell meshwork extending beyond the lymphoid follicles.
  • [MeSH-major] Chemokine CXCL13 / metabolism. Dendritic Cells, Follicular / pathology. Immunoblastic Lymphadenopathy / pathology. Lymphoma, T-Cell, Peripheral / pathology. Neprilysin / metabolism

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  • (PMID = 19575853.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / CXCL13 protein, human; 0 / Chemokine CXCL13; 0 / Proto-Oncogene Proteins c-bcl-6; 0 / Receptors, Complement 3d; EC 3.4.24.11 / Neprilysin
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17. Susarla SM, Sharaf BA, Faquin W, Hasserjian RP, McDermott N, Lahey E: Extranodal natural killer T-cell lymphoma, nasal type, with minimal osseous involvement: report of a case and literature review. J Oral Maxillofac Surg; 2010 Mar;68(3):674-81
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  • [Title] Extranodal natural killer T-cell lymphoma, nasal type, with minimal osseous involvement: report of a case and literature review.
  • [MeSH-major] Facial Neoplasms / pathology. Lymphoma, Extranodal NK-T-Cell / pathology
  • [MeSH-minor] Diagnosis, Differential. Female. Herpesvirus 4, Human / genetics. Humans. Middle Aged. RNA, Viral / analysis. Tomography, X-Ray Computed

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  • (PMID = 19959270.001).
  • [ISSN] 1531-5053
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Viral
  • [Number-of-references] 26
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18. Meng W, Zhou Y, Zhang H, Jiang L, Wang Z, Li X, Zhou H, Chen Q, Zeng X: Nasal-type NK/T-cell lymphoma with palatal ulcer as the earliest clinical manifestation: a case report with literature review. Pathol Oncol Res; 2010 Mar;16(1):133-7
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  • [Title] Nasal-type NK/T-cell lymphoma with palatal ulcer as the earliest clinical manifestation: a case report with literature review.
  • Extranodal nasal natural killer (NK)/T-cell lymphoma is a very rare kind of lymphoma, Oral cavity involvement of extranodal natural killer/T-cell lymphoma, nasal type is extremely rare, and its clinicopathologic features are also poorly understood.
  • Recently, we experienced an unusual case of Epstein-Barr virus-associated, extranodal NK/T-cell type with a unhealed palatal ulcer as the earliest clinical feature.
  • It is a challenge for oral medicine specialists to make the early diagnosis for this special type of tumor.
  • [MeSH-major] Lymphoma, Extranodal NK-T-Cell / pathology. Mouth Neoplasms / pathology. Palate / pathology. Ulcer / pathology

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  • (PMID = 19590983.001).
  • [ISSN] 1532-2807
  • [Journal-full-title] Pathology oncology research : POR
  • [ISO-abbreviation] Pathol. Oncol. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 13
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19. Mozos A, Ye H, Chuang WY, Chu JS, Huang WT, Chen HK, Hsu YH, Bacon CM, Du MQ, Campo E, Chuang SS: Most primary adrenal lymphomas are diffuse large B-cell lymphomas with non-germinal center B-cell phenotype, BCL6 gene rearrangement and poor prognosis. Mod Pathol; 2009 Sep;22(9):1210-7
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  • [Title] Most primary adrenal lymphomas are diffuse large B-cell lymphomas with non-germinal center B-cell phenotype, BCL6 gene rearrangement and poor prognosis.
  • Primary adrenal lymphoma is extremely rare, accounting for <1% of non-Hodgkin lymphomas, and lymphoma-associated chromosomal translocations have yet to be reported in this entity.
  • The mean tumor size at diagnosis was 8.5 cm.
  • Histologically, eight cases were diffuse large B-cell lymphoma, all of which carried a non-germinal center B-cell phenotype.
  • Fluorescence in situ hybridization revealed BCL6 gene rearrangement in 5 (83%) of 6 diffuse large B-cell lymphomas investigated.
  • The remaining cases were one case each of plasmablastic lymphoma and extranodal NK/T-cell lymphoma, nasal type, the first and third case of primary adrenal lymphoma of these particular lymphoma subtypes in the English literature, respectively.
  • At a median follow-up of 4.5 months, 7 patients died of lymphoma, 1 died of an unrelated disease, 1 was alive with disease, and 1 was alive without disease.
  • The prognosis of these patients was poor as compared with those with nodal diffuse large B-cell lymphoma.
  • We speculate that the poor outcome of primary adrenal lymphoma might be related to the bulky tumor size at presentation, non-germinal center B-cell phenotype, and frequent BCL-6 gene rearrangement.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. B-Lymphocytes / pathology. DNA-Binding Proteins / genetics. Gene Rearrangement. Lymphoma, Large B-Cell, Diffuse / pathology

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  • (PMID = 19525926.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / BCL6 protein, human; 0 / DNA-Binding Proteins
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20. Costes V: [Lymphoid lesions of the head and neck]. Ann Pathol; 2009 Sep;29(4):323-34
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  • [Transliterated title] Pathologie lymphoïde de la tête et du cou.
  • Lymphoid lesions of the head and neck mainly affect four regions: Waldeyer's ring, nasal and paranasal sinus, oral cavity and salivary glands.
  • Waldeyer's ring, functionally similar to the mucosal associated lymphoid tissue of the gastrointestinal tract is most commonly affected by large B-cell lymphomas.
  • The nasal cavity and paranasal sinuses are the typical site of extranodal NK/T-cell lymphoma, nasal type, a proliferation of cytotoxic, EBV infected cells.
  • Plasmablastic lymphoma have been first described in oral cavity in HIV patients.
  • Endemic Burkitt lymphoma, considered as a polymicrobial disease associated with the t(14;18) translocation presented in the great majority of cases as a jaw tumor with oral extension.
  • It represents a pre lymphomatous state of marginal zone lymphoma.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Lymphatic Diseases / pathology. Lymphoma / pathology

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  • (PMID = 19900637.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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21. Wong T, Ko JY, Wang FS, Chen YJ, Ma MC: Epstein-Barr virus associated extranodal natural killer T cell lymphoma of nasal type mimicking pyogenic osteomyelitis of the proximal humerus. Chang Gung Med J; 2008 May-Jun;31(3):314-9
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  • [Title] Epstein-Barr virus associated extranodal natural killer T cell lymphoma of nasal type mimicking pyogenic osteomyelitis of the proximal humerus.
  • Extranodal natural killer (NK) cell lymphoma/leukemia, nasal type, is rare but highly aggressive.
  • We report a male patient who suffered from EBV associated NK/T cell lymphoma of the proximal humerus but presented as pyogenic osteomyelitis with the clinical signs and symptoms of fever, local erythema, elevated erythrocyte sedimation rate and C-reactive protein.
  • The patient developed tumor recurrence and died due to pneumonia and respiratory failure 10 months after the initial diagnosis.
  • The purpose of this case report was to emphasize the unusual presentation of a neoplasm mimicking osteomyelitis.
  • [MeSH-major] Epstein-Barr Virus Infections / complications. Humerus. Lymphoma, Extranodal NK-T-Cell / diagnosis. Osteomyelitis / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male. Suppuration

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  • (PMID = 18782956.001).
  • [ISSN] 2072-0939
  • [Journal-full-title] Chang Gung medical journal
  • [ISO-abbreviation] Chang Gung Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
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22. Mitarnun W, Suwiwat S, Pradutkanchana J: Epstein-Barr virus-associated extranodal non-Hodgkin's lymphoma of the sinonasal tract and nasopharynx in Thailand. Asian Pac J Cancer Prev; 2006 Jan-Mar;7(1):91-4
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  • [Title] Epstein-Barr virus-associated extranodal non-Hodgkin's lymphoma of the sinonasal tract and nasopharynx in Thailand.
  • Epstein-Barr virus (EBV) infection is highly associated with specific subtypes of malignant lymphoma.
  • In our previous report on nodal malignant lymphoma in Thailand, we found that 64% of classical Hodgkin's lymphoma (cHL), 51% of non-Hodgkin's lymphoma, T-cell (NHL-T), and 13% of non-Hodgkin's lymphoma, B-cell (NHL-B) were EBV-related.
  • In the present research, we conducted a retrospective study of primary extranodal non-Hodgkin's lymphoma of the sinonasal tract (e-NHL-ST) and primary extranodal non-Hodgkin's lymphoma of the nasopharynx (e-NHL-NP) in Southern Thailand, between 1997 and 2004.
  • EBV-encoded RNA (EBER) expression by in situ hybridization was performed in all cases and a T-cell receptor (TCR)-g gene rearrangement study was performed in NHL-T cases.
  • The percentages of e-NHL-ST and e-NHL-NP as compared to nodal malignant lymphoma were 3.7% and 6.8%, respectively.
  • Monoclonal bands of the TCR-gamma gene were detected in 71.4% of the extranodal NK/T-cell lymphomas, nasal type, patients; 50.0% of peripheral T-cell lymphoma, unspecified, patients; and one case of angioimmunoblastic T-cell lymphoma.
  • The study also indicates that most cases of extranodal NK/T-cell lymphoma, nasal type, are not the germline configuration of the TCR genes.
  • [MeSH-major] Herpesvirus 4, Human / isolation & purification. Lymphoma, Non-Hodgkin / epidemiology. Lymphoma, Non-Hodgkin / virology. Nasopharyngeal Neoplasms / virology. Paranasal Sinus Neoplasms / virology
  • [MeSH-minor] Adult. Age Distribution. Aged. Aged, 80 and over. Cohort Studies. DNA, Viral / analysis. Female. Humans. In Situ Hybridization. Incidence. Lymph Nodes / pathology. Lymphoma, T-Cell / epidemiology. Lymphoma, T-Cell / pathology. Lymphoma, T-Cell / virology. Male. Middle Aged. Polymerase Chain Reaction. Prognosis. Retrospective Studies. Risk Assessment. Sex Distribution. Survival Rate. Thailand / epidemiology

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  • (PMID = 16629523.001).
  • [ISSN] 1513-7368
  • [Journal-full-title] Asian Pacific journal of cancer prevention : APJCP
  • [ISO-abbreviation] Asian Pac. J. Cancer Prev.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Thailand
  • [Chemical-registry-number] 0 / DNA, Viral
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23. Papalkar D, Sharma S, Francis IC, Downie JA, Thanakrishnan G, Hughes LJ: A rapidly fatal case of T-cell lymphoma presenting as idiopathic orbital inflammation. Orbit; 2005 Jun;24(2):131-3
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  • [Title] A rapidly fatal case of T-cell lymphoma presenting as idiopathic orbital inflammation.
  • Post-mortem examination demonstrated widespread extranodal NK/T- cell lymphoma (nasal type), involving the right posterior orbit, lungs, uterus, left adrenal gland, pericardium and meninges.
  • [MeSH-major] Diagnostic Errors. Lymphoma, T-Cell / diagnosis. Orbital Neoplasms / diagnosis
  • [MeSH-minor] Adult. Fatal Outcome. Female. Humans. Inflammation. Killer Cells, Natural / immunology. Neoplasm Metastasis. T-Lymphocytes

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  • (PMID = 16191803.001).
  • [ISSN] 0167-6830
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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24. Liao JB, Chuang SS, Chen HC, Tseng HH, Wang JS, Hsieh PP: Clinicopathologic analysis of cutaneous lymphoma in taiwan: a high frequency of extranodal natural killer/t-cell lymphoma, nasal type, with an extremely poor prognosis. Arch Pathol Lab Med; 2010 Jul;134(7):996-1002
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  • [Title] Clinicopathologic analysis of cutaneous lymphoma in taiwan: a high frequency of extranodal natural killer/t-cell lymphoma, nasal type, with an extremely poor prognosis.
  • CONTEXT: Primary cutaneous lymphoma is an uncommon, extranodal lymphoma, and it is usually more indolent with a better prognosis than its histologically similar systemic counterpart is.
  • OBJECTIVES: To illustrate the clinicopathologic features of cutaneous lymphomas in Taiwan and to compare the relative frequencies of subtypes of cutaneous lymphoma among different geographic areas.
  • DESIGN: A total of 56 patients with cutaneous lymphomas were retrospectively collected and were reclassified according to the 2005 World Health Organization and the European Organization for Research and Treatment of Cancer and the 2008 World Health Organization classifications.
  • RESULTS: Thirty-one (55%) tumors were primary cutaneous lymphomas, and twenty-five (45%) tumors were secondary or concurrent cutaneous lymphomas.
  • Among primary cutaneous lymphomas, 23 cases (74%) were T-cell or natural killer-cell lymphomas, and 8 cases (26%) were B-cell lymphomas.
  • The most common types were extranodal natural killer/T-cell lymphoma, nasal type, and primary cutaneous peripheral T-cell lymphoma, unspecified (5 cases each; 16%).
  • In contrast with other primary cutaneous B-cell and T-cell lymphomas, either primary or secondary extranodal cutaneous natural killer/T-cell lymphomas, nasal type, had extremely poor prognoses (1-year overall survival, 0%).
  • CONCLUSIONS: This study showed that the frequency of subtypes of primary cutaneous lymphoma varied in different geographic areas.
  • Compared with the Western countries, there was a higher frequency of extranodal natural killer/T-cell lymphoma, nasal type, and a lower frequency of mycosis fungoides in Taiwan.
  • Extranodal natural killer/T-cell lymphoma, nasal type, also had an extremely poor prognosis compared with other lymphomas.
  • [MeSH-major] Lymphoma / epidemiology. Lymphoma / pathology. Lymphoma / physiopathology. Lymphoma, T-Cell, Cutaneous / epidemiology. Nose Neoplasms / epidemiology. Skin Neoplasms / epidemiology. Skin Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Female. Humans. Incidence. Killer Cells, Natural / pathology. Male. Middle Aged. Mycosis Fungoides / epidemiology. Prognosis. Retrospective Studies. Taiwan / epidemiology. Young Adult


25. Ko OB, Lee DH, Kim SW, Lee JS, Kim S, Huh J, Suh C: Clinicopathologic characteristics of T-cell non-Hodgkin's lymphoma: a single institution experience. Korean J Intern Med; 2009 Jun;24(2):128-34
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  • [Title] Clinicopathologic characteristics of T-cell non-Hodgkin's lymphoma: a single institution experience.
  • BACKGROUND/AIMS: Although the incidence of T-cell non-Hodgkin's lymphoma (NHL) is higher in Far East Asia than in Western countries, its incidence and clinical course in Korea are not well-defined.
  • Therefore, we assessed the relative frequency and clinical features of T-cell NHL in Korea.
  • RESULTS: 101 (17.2%) had T-cell NHL.
  • The most frequent subtypes of T-cell NHL were extranodal NK/T-cell lymphoma, nasal type (NASAL), peripheral T-cell lymphoma, unspecified type (PTCL-U), and anaplastic large cell lymphoma, T/null cell, primary systemic type (ALCL).
  • Univariate analysis of IPI elements and other clinical features showed that clinical stage and extranodal sites were significant predictors of survival.
  • Cox multivariate analysis showed that the number of extranodal sites was the only independent prognostic indicator.
  • CONCLUSIONS: The relative frequency of T-cell NHL seems to be decreasing in Korea, although NASAL remains frequent.
  • Large-scale studies are warranted for Korean patients with T-cell NHL.
  • [MeSH-major] Lymphoma, Non-Hodgkin / mortality. Lymphoma, Non-Hodgkin / pathology. Lymphoma, T-Cell / mortality. Lymphoma, T-Cell / pathology

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  • (PMID = 19543491.001).
  • [ISSN] 1226-3303
  • [Journal-full-title] The Korean journal of internal medicine
  • [ISO-abbreviation] Korean J. Intern. Med.
  • [Language] eng
  • [Publication-type] Journal Article
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  • [Keywords] NOTNLM ; Lymphoma / Peripheral / T-cell
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26. Suzuki R: Treatment of advanced extranodal NK/T cell lymphoma, nasal-type and aggressive NK-cell leukemia. Int J Hematol; 2010 Dec;92(5):697-701
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  • [Title] Treatment of advanced extranodal NK/T cell lymphoma, nasal-type and aggressive NK-cell leukemia.
  • Extranodal NK/T cell lymphoma, nasal type (ENKL) with advanced stage and aggressive NK-cell leukemia (ANKL) are highly aggressive neoplasms with a dismal clinical outcome.
  • This is a major reason for the refractoriness to conventional chemotherapeutic regimens for malignant lymphoma containing anthracycline.
  • ANKL needs another treatment strategy because of a systemic disease progression and extensive organ insufficiency.
  • Optimal treatment scheme using such effective agents for these unfavorable NK-cell tumors should further be explored.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Killer Cells, Natural / pathology. Leukemia, T-Cell / therapy. Lymphoma, Extranodal NK-T-Cell / drug therapy

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  • (PMID = 21116747.001).
  • [ISSN] 1865-3774
  • [Journal-full-title] International journal of hematology
  • [ISO-abbreviation] Int. J. Hematol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 6PLQ3CP4P3 / Etoposide; 7S5I7G3JQL / Dexamethasone; EC 3.5.1.1 / Asparaginase; UM20QQM95Y / Ifosfamide; YL5FZ2Y5U1 / Methotrexate
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27. Han DM, Chen XQ, Bai QX: [Exploration of prognostic factors in extranodal nasal-type NK/T cell lymphoma]. Zhonghua Zhong Liu Za Zhi; 2006 Feb;28(2):137
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  • [Title] [Exploration of prognostic factors in extranodal nasal-type NK/T cell lymphoma].
  • [MeSH-major] Killer Cells, Natural. Lymphoma, T-Cell. Nose Neoplasms

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  • (PMID = 16750021.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Hemoglobins; 9007-73-2 / Ferritins; EC 1.1.1.27 / L-Lactate Dehydrogenase
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28. Iezzoni JC, Mills SE: "Undifferentiated" small round cell tumors of the sinonasal tract: differential diagnosis update. Am J Clin Pathol; 2005 Dec;124 Suppl:S110-21
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  • [Title] "Undifferentiated" small round cell tumors of the sinonasal tract: differential diagnosis update.
  • Accordingly, this review will discuss the differential diagnosis of undifferentiated small blue cell tumors of the sinonasal tract based on the light microscopic and clinical features and, as needed, the results of these ancillary studies.
  • Tumors discussed include olfactory neuroblastoma, sinonasal undifferentiated carcinoma, small cell undifferentiated (neuroendocrine) carcinoma, undifferentiated (lymphoepithelioma-like) carcinoma, malignant melanoma, pituitary adenoma, Ewing sarcoma/peripheral neuroectodermal tumor, rhabdomyosarcoma, mesenchymal chondrosarcoma, small cell osteosarcoma, synovial sarcoma, extranodal natural killer/T-cell lymphoma, nasal type, and extramedullary plasmacytoma.
  • [MeSH-major] Nasal Cavity / pathology. Nose Neoplasms / pathology
  • [MeSH-minor] Carcinoma, Small Cell / pathology. Chondrosarcoma / pathology. Diagnosis, Differential. Esthesioneuroblastoma, Olfactory / pathology. Humans. Osteosarcoma / pathology. Paranasal Sinus Neoplasms / pathology. Pituitary Neoplasms / pathology. Plasmacytoma / pathology. Rhabdomyosarcoma / pathology

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  • (PMID = 16468421.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 61
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29. Li Z, Liu WP, Tang Y, Jiang LL, Zhang WY, Bi CF, Li GD: [Splenic T-cell and NK-cell lymphomas: a clinicopathologic and immunophenotypic analysis of 9 cases]. Zhonghua Xue Ye Xue Za Zhi; 2007 Apr;28(4):217-22
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  • [Title] [Splenic T-cell and NK-cell lymphomas: a clinicopathologic and immunophenotypic analysis of 9 cases].
  • OBJECTIVE: To explore the clinicopathologic features and diagnosis of splenic T-cell and NK-cell neoplasms.
  • METHODS: Nine cases of splenic T-cell and NK-cell neoplasms were collected and studied by morphology, immunophenotyping, EBER in situ hybridization and TCR-gamma gene rearrangement.
  • RESULTS: Among the 9 cases, hepatosplenic T-cell lymphoma (HSTCL) and extranodal nasal type NK/T-cell lymphoma (NK/TCL) were both of 4 cases, and the remaining one was peripheral T-cell lymphoma, unspecified (PTL, unspecified).
  • Five patients including 2 with HSTCL, 2 with extranodal nasal type NK/TCL and one with PTL, unspecified died, with survival times ranged from 1 to 10 months.
  • The other two patients are still alive, one with NK/TCL (two months+) and one with HSTCL (14+ months).
  • CONCLUSION: Splenic T-cell and NK-cell neoplasms are a group of uncommon lymphomas with heterogeneous clinicopathologic features and poor prognosis.
  • A definite diagnosis must depend on clinical manifestations, histopathology, immunophenotype and TCR gene rearrangement analysis.
  • [MeSH-major] Lymphoma, Extranodal NK-T-Cell / pathology. Lymphoma, T-Cell, Peripheral / pathology. Splenic Neoplasms / pathology

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  • (PMID = 17877195.001).
  • [ISSN] 0253-2727
  • [Journal-full-title] Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
  • [ISO-abbreviation] Zhonghua Xue Ye Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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30. Lee J, Suh C, Park YH, Ko YH, Bang SM, Lee JH, Lee DH, Huh J, Oh SY, Kwon HC, Kim HJ, Lee SI, Kim JH, Park J, Oh SJ, Kim K, Jung C, Park K, Kim WS: Extranodal natural killer T-cell lymphoma, nasal-type: a prognostic model from a retrospective multicenter study. J Clin Oncol; 2006 Feb 1;24(4):612-8
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  • [Title] Extranodal natural killer T-cell lymphoma, nasal-type: a prognostic model from a retrospective multicenter study.
  • PURPOSE: Patients with natural killer T (NK/T) -cell lymphomas have poor survival outcome, and for this condition there is no optimal therapy.
  • The purpose of this study was to design a prognostic model specifically for extranodal NK/T-cell lymphoma, which can identify high-risk patients who need more aggressive therapy.
  • PATIENTS AND METHODS: This multicenter retrospective study was comprised of 262 patients who were diagnosed with NK/T-cell lymphoma.
  • CONCLUSION: The newly proposed model for extranodal NK/T-cell lymphoma demonstrated a more balanced distribution of patients into four groups with better prognostic discrimination as compared with the IPI.
  • [MeSH-major] Killer Cells, Natural. Lymphoma, T-Cell / diagnosis. Nose Neoplasms / diagnosis

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  • (PMID = 16380410.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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31. Liu X, Wang B, Ma X, Guo Y: NF-kappaB activation through the alternative pathway correlates with chemoresistance and poor survival in extranodal NK/T-cell lymphoma, nasal type. Jpn J Clin Oncol; 2009 Jul;39(7):418-24
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  • [Title] NF-kappaB activation through the alternative pathway correlates with chemoresistance and poor survival in extranodal NK/T-cell lymphoma, nasal type.
  • The aim of our study was to determine the expression status and clinical significance of NF-kappaB in extranodal natural killer (NK)/T-cell lymphoma, nasal type.
  • METHODS: Tumor specimens from 23 patients with previously untreated NK/T-cell lymphoma initially treated with cyclophosphamide, vincristine, doxorubicin and prednisone (CHOP) or CHOP-based chemotherapy were examined by immunohistochemistry for three NF-kappaB subunits (p65, p50 and p52), which are involved in either the canonical or alternative pathway.
  • CONCLUSIONS: Our results suggest that NF-kappaB activation through the alternative pathway is frequently observed in NK/T-cell lymphoma and associated with chemoresistance and poor survival.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Lymphoma, Extranodal NK-T-Cell / metabolism. Lymphoma, Extranodal NK-T-Cell / mortality. NF-kappa B / metabolism. Nose Neoplasms / metabolism. Nose Neoplasms / mortality
  • [MeSH-minor] Adolescent. Adult. Aged. Cell Nucleus / metabolism. Cyclophosphamide / therapeutic use. Doxorubicin / therapeutic use. Drug Resistance, Neoplasm. Female. Humans. Immunoenzyme Techniques. Male. Middle Aged. Neoplasm Staging. Prednisolone / therapeutic use. Prognosis. Risk Factors. Signal Transduction. Survival Rate. Treatment Outcome. Vincristine / therapeutic use. Young Adult

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  • (PMID = 19395464.001).
  • [ISSN] 1465-3621
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / NF-kappa B; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; 9PHQ9Y1OLM / Prednisolone; VAP-cyclo protocol
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32. Huang WT, Chang KC, Huang GC, Hsiao JR, Chen HH, Chuang SS, Chen TY, Su WC, Tsao CJ: Bone marrow that is positive for Epstein-Barr virus encoded RNA-1 by in situ hybridization is related with a poor prognosis in patients with extranodal natural killer/T-cell lymphoma, nasal type. Haematologica; 2005 Aug;90(8):1063-9
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  • [Title] Bone marrow that is positive for Epstein-Barr virus encoded RNA-1 by in situ hybridization is related with a poor prognosis in patients with extranodal natural killer/T-cell lymphoma, nasal type.
  • BACKGROUND AND OBJECTIVES: Extranodal NK/T-cell lymphoma, nasal type is an aggressive lymphoma that is always associated with Epstein-Barr virus (EBV).
  • This study was done to evaluate the use of EBV-encoded RNA-1 in situ hybridization (EBER-1 ISH) to detect occult micrometastasis in the bone marrow (BM) of patients with nasal NK/T-cell lymphoma.
  • RESULTS: Conventional morphologic examinations failed to identify any lymphoma involvement in the 23 BM specimens obtained at initial staging.
  • Only the BM EBER-1 ISH result was shown to be an independent variable predicting overall survival in stage I and II patients (p=0.027; hazard ratio for death 0.066, 95% confidence interval, 0.006 to 0.733), suggesting that EBER-1 positivity in BM is the major determinant of a poor prognosis.
  • INTERPRETATION AND CONCLUSIONS: We suggest that EBER-1 ISH should be performed on BM specimens of patients with nasal NK/T-cell lymphoma to identify the presence of EBER-1 positive cells, which appears to carry a poor prognosis.
  • Whether or not the EBER-1 positive cells in the BM of nasal NK/T-cell lymphoma patients are true tumor cells requires further study.
  • [MeSH-major] Bone Marrow Cells / pathology. Bone Marrow Cells / virology. Herpesvirus 4, Human / genetics. Killer Cells, Natural / immunology. Lymphoma, T-Cell / immunology. RNA, Viral / genetics

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  • [CommentIn] Haematologica. 2005 Aug;90(8):1011A [16079092.001]
  • (PMID = 16079105.001).
  • [ISSN] 1592-8721
  • [Journal-full-title] Haematologica
  • [ISO-abbreviation] Haematologica
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / DNA Primers; 0 / Epstein-Barr virus encoded RNA 1; 0 / RNA, Viral
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33. Velázquez-Arenas L, Vázquez-Martínez OT, Méndez-Olvera N, Barboza-Quintana O, Gómez M, Ocampo-Candiani J: [Extranodal natural killer/T-cell lymphoma, nasal type]. Actas Dermosifiliogr; 2008 May;99(4):316-7
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  • [Title] [Extranodal natural killer/T-cell lymphoma, nasal type].
  • [Transliterated title] Linfoma de células T/NK extranodal tipo nasal.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Lymphoma, Extranodal NK-T-Cell / pathology

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  • (PMID = 18394414.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Spain
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34. Morovic A, Aurer I, Dotlic S, Weisenburger DD, Nola M: NK cell lymphoma, nasal type, with massive lung involvement: a case report. J Hematop; 2010;3(1):19-22
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  • [Title] NK cell lymphoma, nasal type, with massive lung involvement: a case report.
  • Extranodal NK/T cell lymphoma, nasal type, is an Epstein-Barr virus-associated lymphoma that most commonly involves the nasal cavity and upper respiratory tract.
  • Lung involvement by NK/T cell lymphoma is rare and seldom reported in the literature.
  • We describe the unusual case of a 41-year-old male with NK cell lymphoma, nasal type, who presented with massive secondary lung involvement 2.5 years after the detection of a retroperitoneal mass.
  • The diagnosis was made by open lung biopsy.
  • Lung involvement by NK/T cell lymphoma occurs most commonly as part of widely disseminated disease and carries a poor prognosis for the patient.
  • Novel agents and innovative therapies need to be developed for this aggressive lymphoma.

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  • (PMID = 21436870.001).
  • [ISSN] 1865-5785
  • [Journal-full-title] Journal of hematopathology
  • [ISO-abbreviation] J Hematop
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Other-IDs] NLM/ PMC2883903
  • [Keywords] NOTNLM ; Epstein–Barr virus / Extranodal NK/T lymphoma / Lung involvement
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35. Huang Y, de Reyniès A, de Leval L, Ghazi B, Martin-Garcia N, Travert M, Bosq J, Brière J, Petit B, Thomas E, Coppo P, Marafioti T, Emile JF, Delfau-Larue MH, Schmitt C, Gaulard P: Gene expression profiling identifies emerging oncogenic pathways operating in extranodal NK/T-cell lymphoma, nasal type. Blood; 2010 Feb 11;115(6):1226-37
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gene expression profiling identifies emerging oncogenic pathways operating in extranodal NK/T-cell lymphoma, nasal type.
  • Biopsies and cell lines of natural killer/T-cell lymphoma, nasal type (NKTCL) were subject to combined gene expression profiling and array-based comparative genomic hybridization analyses.
  • Compared with peripheral T-cell lymphoma, not otherwise specified, NKTCL had greater transcript levels for NK-cell and cytotoxic molecules, especially granzyme H.
  • Notably, platelet-derived growth factor receptor alpha and its phosphorylated form were confirmed at the protein level, and in vitro the MEC04 NKTCL cell line was sensitive to imatinib.
  • [MeSH-major] Epstein-Barr Virus Infections / genetics. Gene Expression Profiling. Killer Cells, Natural / pathology. Lymphoma, Extranodal NK-T-Cell / genetics. Nasopharyngeal Neoplasms / genetics. Oncogenes / physiology
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / genetics. Biomarkers, Tumor / metabolism. Blotting, Western. Cell Proliferation. Cells, Cultured. Comparative Genomic Hybridization. Female. Herpesvirus 4, Human / physiology. Humans. Immunoenzyme Techniques. Male. Middle Aged. Nasal Mucosa / metabolism. Nasal Mucosa / pathology. Oligonucleotide Array Sequence Analysis. RNA, Messenger / genetics. RNA, Messenger / metabolism. Receptors, Platelet-Derived Growth Factor / genetics. Receptors, Platelet-Derived Growth Factor / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Signal Transduction. Ubiquitin-Protein Ligases / genetics. Ubiquitin-Protein Ligases / metabolism


36. Brodkin DE, Hobohm DW, Nigam R: Nasal-type NK/T-cell lymphoma presenting as hemophagocytic syndrome in an 11-year-old Mexican boy. J Pediatr Hematol Oncol; 2008 Dec;30(12):938-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nasal-type NK/T-cell lymphoma presenting as hemophagocytic syndrome in an 11-year-old Mexican boy.
  • Recently established by the World Health Organization classification, "nasal" and "nasal-type" NK/T-cell lymphoma arise from natural killer (NK) cells.
  • They have distinct clinicopathologic features, specific genotype and phenotype, and a high association with Epstein-Barr virus infection.
  • Nasal-type NK/T-cell lymphoma arise from extranasal sites including skin, soft tissue, gastrointestinal tract, liver, spleen, testes, lung, and central nervous system.
  • We report an 11-year-old child with extranodal nasal-type NK/T-cell lymphoma presenting as hemophagocytic syndrome and multiorgan system failure with fatal outcome.
  • [MeSH-major] Killer Cells, Natural / pathology. Lymphohistiocytosis, Hemophagocytic / diagnosis. Lymphoma, T-Cell / diagnosis. Nose Neoplasms / diagnosis
  • [MeSH-minor] Child. Diagnosis, Differential. Fatal Outcome. Humans. Male. Mexico. Multiple Organ Failure / diagnosis. Multiple Organ Failure / etiology

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  • (PMID = 19131786.001).
  • [ISSN] 1536-3678
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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37. Kako S, Izutsu K, Oshima K, Sato H, Kanda Y, Motokura T, Chiba S, Kurokawa M: Regression of the tumor after withdrawal of cyclosporine in relapsed extranodal natural killer/T cell lymphoma following allogeneic hematopoietic stem cell transplantation. Am J Hematol; 2007 Oct;82(10):937-9
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  • [Title] Regression of the tumor after withdrawal of cyclosporine in relapsed extranodal natural killer/T cell lymphoma following allogeneic hematopoietic stem cell transplantation.
  • The prognosis of patients with advanced-stage extranodal natural killer/T cell lymphoma, nasal type (ENKL) has been generally poor, and several anecdotal reports have suggested the role of allogeneic hematopoietic stem cell transplantation (HSCT).
  • A potential advantage of allogeneic HSCT may be the graft-versus-lymphoma (GVL) effect.
  • Except for a temporal exacerbation of bronchiolitis obliterans organizing pneumonia, she has been free from disease for more than a year without other treatments against lymphoma.
  • [MeSH-major] Cyclosporine / adverse effects. Hematopoietic Stem Cell Transplantation. Immunosuppressive Agents / adverse effects. Lymphoma, T-Cell, Peripheral / surgery. Neoplasm Recurrence, Local / pathology. Palatal Neoplasms / surgery

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  • (PMID = 17663389.001).
  • [ISSN] 0361-8609
  • [Journal-full-title] American journal of hematology
  • [ISO-abbreviation] Am. J. Hematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Immunosuppressive Agents; 04079A1RDZ / Cytarabine; 5J49Q6B70F / Vincristine; 6PLQ3CP4P3 / Etoposide; 7S5I7G3JQL / Dexamethasone; 80168379AG / Doxorubicin; 83HN0GTJ6D / Cyclosporine; 8N3DW7272P / Cyclophosphamide; BG3F62OND5 / Carboplatin; UM20QQM95Y / Ifosfamide; YL5FZ2Y5U1 / Methotrexate; CVAD protocol
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38. Suzuki R, Takeuchi K, Ohshima K, Nakamura S: Extranodal NK/T-cell lymphoma: diagnosis and treatment cues. Hematol Oncol; 2008 Jun;26(2):66-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extranodal NK/T-cell lymphoma: diagnosis and treatment cues.
  • Extranodal NK/T-cell lymphoma, nasal type (ENKL) is mostly endemic to East Asia.
  • It predominantly occurs in the nasal or paranasal areas and less frequently in the skin.
  • Most of the tumours show NK-cell, but rarely T-cell, phenotypes.
  • The Epstein-Barr virus (EBV) genome can be usually detected in lymphoma cells.
  • Originally, NK-cell and T-cell types were believed to present the same clinicopathologic characteristics, but recent data suggest more aggressive characteristics for the NK-cell phenotype.
  • Although ENKL is sensitive to radiotherapy, it shows a poorer response to chemotherapeutic agents than other lymphomas due to expression of p-glycoprotein.
  • [MeSH-major] Killer Cells, Natural / cytology. Lymphoma, T-Cell, Peripheral / diagnosis. Lymphoma, T-Cell, Peripheral / therapy
  • [MeSH-minor] Antigens, CD56 / biosynthesis. Antineoplastic Agents / pharmacology. Biopsy. Epstein-Barr Virus Infections / complications. Hematopoietic Stem Cell Transplantation. Herpesvirus 4, Human / metabolism. Humans. Immunophenotyping. Medical Oncology / methods. Models, Biological. P-Glycoprotein / metabolism. Phenotype. Treatment Outcome

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  • (PMID = 18283711.001).
  • [ISSN] 0278-0232
  • [Journal-full-title] Hematological oncology
  • [ISO-abbreviation] Hematol Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD56; 0 / Antineoplastic Agents; 0 / P-Glycoprotein
  • [Number-of-references] 74
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39. Fernández-Torres R, Del Pozo J, Alvarez A, Mazaira M, Varela C, Almagro M, Fonseca E: Extranodal NK/T-cell lymphoma, nasal type presenting as a pyogenic granuloma-like on a fingertip. Eur J Dermatol; 2009 Jan-Feb;19(1):79-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extranodal NK/T-cell lymphoma, nasal type presenting as a pyogenic granuloma-like on a fingertip.
  • [MeSH-major] Fingers. Granuloma, Pyogenic / pathology. Killer Cells, Natural / pathology. Lymphoma, T-Cell, Peripheral / pathology

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  • (PMID = 19171539.001).
  • [ISSN] 1167-1122
  • [Journal-full-title] European journal of dermatology : EJD
  • [ISO-abbreviation] Eur J Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] France
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CHOP protocol
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40. Pincus LB, Zehnder JL, Neuhaus IM, Andreadis C, McCalmont TH: Presentation of extranodal natural killer T-cell lymphoma, nasal type, with poorly circumscribed erythematous patches. J Clin Oncol; 2010 Feb 20;28(6):e94-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Presentation of extranodal natural killer T-cell lymphoma, nasal type, with poorly circumscribed erythematous patches.
  • [MeSH-major] Lymphoma, T-Cell, Cutaneous / pathology. Natural Killer T-Cells / pathology. Nose Neoplasms / pathology. Skin Diseases / pathology

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  • (PMID = 19933911.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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41. Wang H, Li XJ, Zhang SW, Xi Y: [Clinical study of extranodal NK-T cell lymphoma-nasal type]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2005 Nov;40(11):850-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinical study of extranodal NK-T cell lymphoma-nasal type].
  • OBJECTIVE: To discuss how the diagnosis, misdiagnosis and different treatment modalities affect the prognosis of the patients with extranodal NK-T cell lymphoma-nasal type.
  • METHODS: A retrospective study was made on the clinical characteristics, treatment modality, short-term effect, and survival rate of 68 patients with extranodal NK-T cell lymphoma-nasal type.
  • 4% (17/18) for limited disease in I(E) group compared 61.9% (26/42) for out-cavity disease in I(E) group, of which the difference is significant (P =0. 012).
  • The 1-years, 3-years and 5-years survival rate of the I(E) intra-cavity group were 100%, 77.8%, 59.8%, and those of ex-cavity group were 80.1%, 48.5% and 14.6%, respectively.
  • CONCLUSIONS: The early clinical manifestation of extranodal NK-T cell lymphoma-nasal type is not typical,which is easy to be misdiagnosed and mistreated.
  • Diseased stage I(E) out-cavity and above should be treated with combined therapy.
  • [MeSH-major] Lymphoma, Extranodal NK-T-Cell. Nose Neoplasms

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  • (PMID = 16408753.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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42. Pullarkat VA, Medeiros LJ, Brynes RK: Body cavity-based presentation of natural killer cell lymphoma. Leuk Lymphoma; 2005 Feb;46(2):293-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Body cavity-based presentation of natural killer cell lymphoma.
  • We describe an unusual case of a 31-year-old Mexican woman who presented with pleural and peritoneal effusions involved by Epstein-Barr virus-positive non-Hodgkin's lymphoma of natural killer (NK)-cell lineage.
  • The patient had no symptoms that could be related to her nasal region, and physical examination and radiologic studies showed no evidence of lymphadenopathy, organomegaly, or other extranodal masses.
  • Thus, this case clinically mimicked body cavity-based lymphoma.
  • Extranodal NK/T-cell lymphoma of nasal type is the current designation for these neoplasms in the recently proposed World Health Organization classification of lymphoid neoplasms.
  • These tumors previously have been referred to many other names, including lethal midline granuloma, midline malignant reticulosis, polymorphic reticulosis, angiocentric immunoproliferative lesion, and angiocentric lymphoma.
  • Nasal-type NK/T-cell lymphomas typically involve the nasal region, but may involve other extranodal sites, such as skin and gastrointestinal tract.
  • The malignant cytologic features and the presence of azurophilic granules within the cell cytoplasm observed in Wright-Giemsa-stained cytocentrifuge preparations led to immunophenotypic and molecular genetic studies that were essential in establishing the correct diagnosis.
  • As demonstrated in the case reported, extranodal NK/T-cell lymphomas of nasal-type can be clinically aggressive and may be associated with paraneoplastic phenomena.
  • [MeSH-major] Killer Cells, Natural / pathology. Lymphoma, T-Cell / pathology. Nose Neoplasms / diagnosis. Pleural Effusion, Malignant / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Herpesvirus 4, Human / isolation & purification. Humans. Pleural Cavity / pathology

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  • (PMID = 15621817.001).
  • [ISSN] 1042-8194
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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43. Ashurov ZM, Lutskaia TD, Mustafaev DM, Golubovskiĭ GA, Kurbanov FF: [Extranodal NK/T-cell lymphoma of the nasal type]. Vestn Otorinolaringol; 2008;(1):73-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Extranodal NK/T-cell lymphoma of the nasal type].
  • [MeSH-major] Lymphoma, Extranodal NK-T-Cell / pathology. Lymphoma, Extranodal NK-T-Cell / surgery. Nose Neoplasms / pathology. Nose Neoplasms / surgery

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  • (PMID = 18454065.001).
  • [ISSN] 0042-4668
  • [Journal-full-title] Vestnik otorinolaringologii
  • [ISO-abbreviation] Vestn. Otorinolaringol.
  • [Language] rus
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Russia (Federation)
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44. Nakamichi N, Fukuhara S, Aozasa K, Morii E: NK-cell intravascular lymphomatosis--a mini-review. Eur J Haematol; 2008 Jul;81(1):1-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] NK-cell intravascular lymphomatosis--a mini-review.
  • However, IVL may also arise from T cells, or more rarely NK cells.
  • The clinicopathological findings in six cases of NK-cell IVL (NK-IVL), including one new case, were summarised and compared with B-cell IVL (B-IVL) and T-cell IVL (T-IVL).
  • Earlier onset of disease and female predominance were found in NK-IVL.
  • NK-IVL was typically Epstein-Barr virus (EBV)-positive, whereas EBV was rarely detected in B-IVL.
  • Cutaneous manifestations were common in NK-IVL with constant EBV infection.
  • B-IVL showed a more favourable prognosis than T- or NK-IVL.
  • Irrespective of immunophenotype, however, IVL showed a less favourable prognosis than ordinary lymphomas within the same immunophenotype.
  • In summary, IVL of the B-, T- and NK-cell phenotypes is clinicopathologically distinct and shows similarities to their more common counterparts, i.e. diffuse large B-cell lymphoma, peripheral T-cell lymphoma, unspecified and extranodal NK/T-cell lymphoma, nasal type.
  • [MeSH-major] Killer Cells, Natural / pathology. Lymphoma, Non-Hodgkin / pathology. Vascular Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Antineoplastic Agents / therapeutic use. Female. Humans. Lymphoma, B-Cell. Lymphoma, T-Cell. Male. Middle Aged. Treatment Outcome

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  • (PMID = 18462254.001).
  • [ISSN] 1600-0609
  • [Journal-full-title] European journal of haematology
  • [ISO-abbreviation] Eur. J. Haematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 50
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45. Wakabayashi S, Arai A, Oshikawa G, Araki A, Watanabe M, Uchida N, Taniguchi S, Miura O: Extranodal NK/T cell lymphoma, nasal type, of the small intestine diagnosed by double-balloon endoscopy. Int J Hematol; 2009 Dec;90(5):605-10
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  • [Title] Extranodal NK/T cell lymphoma, nasal type, of the small intestine diagnosed by double-balloon endoscopy.
  • Extranodal NK/T-cell lymphoma (ENKL), nasal type, is rare and the small intestine is quite extraordinary as a primary lesion site.
  • He was referred to our hospital because of bloody stool and the diagnosis was made by double-balloon endoscopy (DBE) of the small intestine without surgical procedure.
  • Although he remained in CR for about 8 months after BMT, he died of disease recurrence 14 months after the diagnosis was made.
  • We describe the usefulness of DBE for diagnosis and management for ENKL of the small intestine.
  • [MeSH-major] Endoscopy, Gastrointestinal / methods. Intestinal Neoplasms / diagnosis. Lymphoma, Extranodal NK-T-Cell / diagnosis

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  • (PMID = 19936878.001).
  • [ISSN] 1865-3774
  • [Journal-full-title] International journal of hematology
  • [ISO-abbreviation] Int. J. Hematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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46. Zhang YC, Sha Zhao, Yu JB, Lei Shi, He MX, Zhang HY, Liu WP: Gastric involvement of extranodal NK/T-cell lymphoma, nasal type: a report of 3 cases with literature review. Int J Surg Pathol; 2008 Oct;16(4):450-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gastric involvement of extranodal NK/T-cell lymphoma, nasal type: a report of 3 cases with literature review.
  • Gastric involvement of extranodal natural killer/T-cell lymphoma, nasal type is extremely rare, and its clinicopathologic features are also poorly understood.
  • In this article, 3 cases of extranodal natural killer/T-cell lymphoma, nasal type are reported.
  • It is a challenge for pathologist to make the diagnosis for this special type of tumor.
  • In all, 2 of 3 cases had a relevant history of midfacial extranodal natural killer/T-cell lymphoma, nasal type before.
  • [MeSH-major] Lymphoma, Extranodal NK-T-Cell / pathology. Nose Neoplasms / pathology. Stomach Neoplasms / pathology

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  • (PMID = 18492683.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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47. Cho KJ, Cho SG, Lee DH: Natural killer T-cell lymphoma of the tongue. Ann Otol Rhinol Laryngol; 2005 Jan;114(1 Pt 1):55-7
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  • [Title] Natural killer T-cell lymphoma of the tongue.
  • Lymphoma, which represents about 5.4% of all neoplasms and, more significantly, 19% to 28% of malignant neoplasms, is the most common nonepithelial malignancy of the head and neck area in Koreans.
  • Natural killer T-cell (NK/T-cell) lymphoma is a lymphoma of putative natural killer cell lineage.
  • NK/T-cell neoplasms are generally rare, but they are more common in people of East Asian, Mexican, or South American descent.
  • The preferential site of extranodal NK/T-cell lymphoma is the nasal cavity, and there has been no report of NK/T-cell lymphoma developing from the tongue.
  • We encountered a rare case of NK/T-cell lymphoma of the tongue, which we report with a review of the literature.
  • [MeSH-major] Killer Cells, Natural / pathology. Lymphoma, T-Cell / pathology. Tongue Neoplasms / pathology

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  • (PMID = 15697163.001).
  • [ISSN] 0003-4894
  • [Journal-full-title] The Annals of otology, rhinology, and laryngology
  • [ISO-abbreviation] Ann. Otol. Rhinol. Laryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 04079A1RDZ / Cytarabine; 11056-06-7 / Bleomycin; 5J49Q6B70F / Vincristine; 6PLQ3CP4P3 / Etoposide; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; YL5FZ2Y5U1 / Methotrexate; PROMACE-CytaBOM protocol
  • [Number-of-references] 15
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48. Yoon SO, Suh C, Lee DH, Chi HS, Park CJ, Jang SS, Shin HR, Park BH, Huh J: Distribution of lymphoid neoplasms in the Republic of Korea: analysis of 5318 cases according to the World Health Organization classification. Am J Hematol; 2010 Oct;85(10):760-4
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  • Of the total 5,318 patients, 66.9% had mature B-cell neoplasms, 12.5% had mature T/natural killer (NK)-cell neoplasms, 16.4% had precursor lymphoblastic leukemia/lymphoma (ALL/LBL), and 4.1% had Hodgkin's lymphoma.
  • The most common subtypes were diffuse large B-cell lymphoma (30.5%), plasma cell myeloma (14.0%), extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue type (MALT lymphoma; 12.4%), B-cell ALL/LBL (11.3%), Hodgkin's lymphoma (4.1%), peripheral T-cell lymphoma unspecified (4.0%), T-cell ALL/LBL (3.9%), and extranodal NK/T-cell lymphoma of nasal type (3.9%).
  • When the relative proportion of subtypes were compared between two decades (1989-1998 vs. 1999-2008), especially MALT lymphoma has increased in proportion, whereas T/NK-cell neoplasms and ALL/LBL have slightly decreased.
  • Although the increase in incidence of lymphoid neoplasms is relatively modest in Korea, recent increase of MALT lymphoma and decrease of T/NK-cell neoplasms and ALL/LBL are interesting findings.
  • [MeSH-major] Lymphoma / epidemiology
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Hodgkin Disease / epidemiology. Hodgkin Disease / pathology. Humans. Immunophenotyping. Incidence. Lymphoma, B-Cell / epidemiology. Lymphoma, B-Cell / pathology. Lymphoma, B-Cell, Marginal Zone / epidemiology. Lymphoma, B-Cell, Marginal Zone / pathology. Lymphoma, T-Cell / epidemiology. Lymphoma, T-Cell / pathology. Male. Middle Aged. Precursor Cell Lymphoblastic Leukemia-Lymphoma / epidemiology. Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology. Republic of Korea / epidemiology. Retrospective Studies. World Health Organization. Young Adult

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  • [Copyright] © 2010 Wiley-Liss, Inc.
  • (PMID = 20806229.001).
  • [ISSN] 1096-8652
  • [Journal-full-title] American journal of hematology
  • [ISO-abbreviation] Am. J. Hematol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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49. Gill H, Liang RH, Tse E: Extranodal natural-killer/t-cell lymphoma, nasal type. Adv Hematol; 2010;2010:627401
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  • [Title] Extranodal natural-killer/t-cell lymphoma, nasal type.
  • The World Health Organization (WHO) classification recognizes 2 main categories of natural killer (NK) cell-derived neoplasms, namely, extranodal NK/T-cell lymphoma, nasal type, and aggressive NK-cell leukaemia.
  • Extranodal nasal NK/T-cell lymphoma is more frequent in the Far East and Latin America.
  • Early stage disease, in particular for localized lesion in the nasal region, is treated with chemotherapy and involved-field radiotherapy.
  • The role of autologous hematopoietic stem cell transplantation is yet to be clearly defined.
  • Allogeneic hematopoietic stem cell transplantation, with the putative graft-versus-lymphoma effect, offers a potentially curative option in patients with advanced disease.

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  • (PMID = 21234094.001).
  • [ISSN] 1687-9112
  • [Journal-full-title] Advances in hematology
  • [ISO-abbreviation] Adv Hematol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3018635
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50. Isobe K, Uno T, Tamaru J, Kawakami H, Ueno N, Wakita H, Okada J, Itami J, Ito H: Extranodal natural killer/T-cell lymphoma, nasal type: the significance of radiotherapeutic parameters. Cancer; 2006 Feb 1;106(3):609-15
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  • [Title] Extranodal natural killer/T-cell lymphoma, nasal type: the significance of radiotherapeutic parameters.
  • METHODS: The current study included 35 patients who were diagnosed with immunohistochemically confirmed nasal natural killer (NK)/T-cell lymphoma between 1976 and 2004.
  • The primary tumor originated in the nasal cavity in 28 patients, and 32 patients had Stage I disease.
  • CONCLUSIONS: In the management of nasal NK/T-cell lymphoma, the RT field affected treatment outcomes.
  • [MeSH-major] Lymphoma, T-Cell / radiotherapy. Neoplasm Recurrence, Local. Nose Neoplasms / radiotherapy
  • [MeSH-minor] Adolescent. Adult. Aged. Disease-Free Survival. Dose-Response Relationship, Radiation. Female. Humans. Immunohistochemistry. Killer Cells, Natural. Male. Middle Aged. Retrospective Studies. Treatment Outcome

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  • [Copyright] Copyright (c) 2005 American Cancer Society.
  • (PMID = 16369986.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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51. Sitthinamsuwan P, Pongpruttipan T, Chularojmontri L, Pattanaprichakul P, Khuhapinant A, Sukpanichnant S: Extranodal NK/T cell lymphoma, nasal type, presenting with primary cutaneous lesion mimicking granulomatous panniculitis: a case report and review of literature. J Med Assoc Thai; 2010 Aug;93(8):1001-7
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  • [Title] Extranodal NK/T cell lymphoma, nasal type, presenting with primary cutaneous lesion mimicking granulomatous panniculitis: a case report and review of literature.
  • BACKGROUND: Cutaneous extranodal NK/T-cell lymphoma, nasal type (NK/T) is relatively rare, associated with aggressive behavior and poor prognosis.
  • Histopathological findings, immunohistochemical study and EBV-encoded RNA (EBER) in situ hybridization are essential for the diagnosis.
  • CASE REPORT: A 54-year-old Thai man with NK/T of the nasal cavity initially presented with cutaneous NK/T mimicking granulomatous panniculitis.
  • CONCLUSION: Cutaneous NK/T can produce granulomatous panniculitis.
  • The recognition of atypical lymphoid cells showing angiocentricity together with immunohistochemistry and EBER in situ hybridization are crucial for the correct diagnosis.
  • [MeSH-major] Lymphoma, Extranodal NK-T-Cell / pathology. Nasal Cavity / pathology. Nose Neoplasms / pathology. Panniculitis / pathology
  • [MeSH-minor] Biopsy. Diagnosis, Differential. Fatal Outcome. Humans. Immunohistochemistry. Lymphoma, T-Cell, Cutaneous / pathology. Male. Middle Aged. Skin Neoplasms / pathology

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  • (PMID = 20718178.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Thailand
  • [Number-of-references] 25
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52. Monma F, Ueno S, Yamaguchi M, Tawara I, Miyazaki K, Nishii K, Nakase K, Katayama N: [Long-term remission of a nasal NK/T-cell lymphoma patient with massive involvement of the orbita and liver dysfunction]. Rinsho Ketsueki; 2009 Jan;50(1):44-8
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  • [Title] [Long-term remission of a nasal NK/T-cell lymphoma patient with massive involvement of the orbita and liver dysfunction].
  • Histopathologic examination of the biopsied right orbital tumor demonstrated extranodal NK/T-cell lymphoma, nasal-type.
  • There is no evidence of recurrence 56 months after diagnosis.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Liver Diseases / complications. Lymphoma, Extranodal NK-T-Cell / drug therapy. Lymphoma, Extranodal NK-T-Cell / radiotherapy. Nose Neoplasms / drug therapy. Nose Neoplasms / radiotherapy. Orbital Neoplasms / drug therapy. Orbital Neoplasms / radiotherapy

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  • (PMID = 19225229.001).
  • [ISSN] 0485-1439
  • [Journal-full-title] [Rinshō ketsueki] The Japanese journal of clinical hematology
  • [ISO-abbreviation] Rinsho Ketsueki
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 6PLQ3CP4P3 / Etoposide; 7S5I7G3JQL / Dexamethasone; EC 3.5.1.1 / Asparaginase
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53. Takahashi E, Asano N, Li C, Tanaka T, Shimada K, Shimada S, Yoshino T, Kojima M, Hara K, Eimoto T, Nakamura S: Nodal T/NK-cell lymphoma of nasal type: a clinicopathological study of six cases. Histopathology; 2008 Apr;52(5):585-96
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  • [Title] Nodal T/NK-cell lymphoma of nasal type: a clinicopathological study of six cases.
  • AIMS: To investigate the clinicopathological features of six unusual cases of nodal CD56+ and Epstein-Barr virus (EBV)+ T/natural killer (NK)-cell lymphoma, a putative nodal counterpart of nasal NK/T-cell lymphoma (nodal T/NK-cell lymphoma of nasal type) in comparison with nasal NK/T-cell lymphoma with secondary lymph node involvement (n = 24) and peripheral T-cell lymphoma (PTCL) of cytotoxic molecule (CTM)+ and EBV+ type (n = 21).
  • METHODS AND RESULTS: All cases of nodal T/NK-cell lymphoma of nasal type exhibited diffuse infiltration of pleomorphic medium-sized to large tumour cells, reminiscent of those in CTM+ EBV+ PTCL.
  • The tumour cells had a typical phenotype of nasal NK/T-cell lymphoma: CD2+, CD3epsilon+, CD4-, CD5-, CD56+, T-cell intracellular antigen-1+, granzyme B+, perforin+ and EBV+.
  • However, four of six cases demonstrated clonal T-cell receptor gamma-gene rearrangement on polymerase chain reaction analysis, unlike nasal NK/T-cell lymphoma.
  • CONCLUSIONS: Nodal T/NK-cell lymphoma may occupy the grey zone between extranodal nasal-type NK/T-cell lymphoma and nodal CTM+ PTCL in a spectrum of NK to T-cell lymphomas that are EBV+.
  • The close relationship between NK/T-cell lymphomas and cytotoxic T-cell lymphomas was also substantiated.
  • [MeSH-major] Epstein-Barr Virus Infections / pathology. Killer Cells, Natural / pathology. Lymph Nodes / pathology. Lymphoma, T-Cell, Peripheral / pathology. Nose Neoplasms / pathology. T-Lymphocytes, Cytotoxic / pathology

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  • (PMID = 18370955.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / RNA, Viral
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54. Zhang XX, Xie CH, Xu Y, Deng D, Zhao YH, Zou BW, Zhou L, Li M, Wang J, Liu WP, Huang MJ: Salvage treatment improved survival of patients with relapsed extranodal natural killer/t-cell lymphoma, nasal type. Int J Radiat Oncol Biol Phys; 2009 Jul 1;74(3):747-52
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  • [Title] Salvage treatment improved survival of patients with relapsed extranodal natural killer/t-cell lymphoma, nasal type.
  • PURPOSE: To evaluate the clinical outcome of salvage treatment for patients with relapsed natural killer (NK)/T-cell lymphoma, nasal type.
  • CONCLUSIONS: Salvage treatment improved survival in patients with relapsed NK/T-cell lymphoma, nasal type.
  • Salvage RT may play an important role in salvage treatment of relapsed extranodal NK/T-cell lymphoma.
  • [MeSH-major] Lymphoma, Extranodal NK-T-Cell / mortality. Salvage Therapy / mortality

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  • (PMID = 19304409.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 6PLQ3CP4P3 / Etoposide; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CHOP protocol; EPOCH protocol
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55. Feldman AL, Law M, Grogg KL, Thorland EC, Fink S, Kurtin PJ, Macon WR, Remstein ED, Dogan A: Incidence of TCR and TCL1 gene translocations and isochromosome 7q in peripheral T-cell lymphomas using fluorescence in situ hybridization. Am J Clin Pathol; 2008 Aug;130(2):178-85
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  • [Title] Incidence of TCR and TCL1 gene translocations and isochromosome 7q in peripheral T-cell lymphomas using fluorescence in situ hybridization.
  • Translocations involving the T-cell receptor (TCR) and TCL1 genes occur in T-cell precursor lymphoblastic leukemia/lymphoma and prolymphocytic leukemia; isochromosome 7q has been associated with hepatosplenic T-cell lymphoma.
  • However, the incidence of these abnormalities in peripheral T-cell lymphomas (PTCLs) as a whole has not been well defined.
  • Isochromosome 7q was detected in 2 cases of extranodal NK/T-cell lymphoma, nasal type, and 2 cases of anaplastic lymphoma kinase-negative anaplastic large cell lymphoma.

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  • (PMID = 18628085.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P50 CA097274; United States / NCI NIH HHS / CA / P50 CA97274
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Proto-Oncogene Proteins; 0 / Receptors, Antigen, T-Cell; 0 / TCL1A protein, human
  • [Other-IDs] NLM/ NIHMS454017; NLM/ PMC3625137
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56. Na II, Kang HJ, Park YH, Lee SS, Yoo HJ, Choe DH, Ryoo BY, Yang SH: Prognostic factors for classifying extranodal NK/T cell lymphoma, nasal type, as lymphoid neoplasia. Eur J Haematol; 2007 Jul;79(1):1-7
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  • [Title] Prognostic factors for classifying extranodal NK/T cell lymphoma, nasal type, as lymphoid neoplasia.
  • This study evaluated the applicability of prognostic factors commonly used for diagnosis of classical lymphoma outcomes to extranodal NK/T cell lymphoma, nasal type (NTCL).
  • [MeSH-major] Killer Cells, Natural / immunology. Lymphoma, T-Cell / classification. Nose Neoplasms / classification

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  • (PMID = 17598834.001).
  • [ISSN] 0902-4441
  • [Journal-full-title] European journal of haematology
  • [ISO-abbreviation] Eur. J. Haematol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] EC 1.1.1.27 / L-Lactate Dehydrogenase
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57. Wang P, Sun Y, Wang Z, Xu A: Primary cutaneous extranodal NK/T-cell lymphoma, nasal type, in an adolescent. Eur J Dermatol; 2010 Jan-Feb;20(1):130-1
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  • [Title] Primary cutaneous extranodal NK/T-cell lymphoma, nasal type, in an adolescent.
  • [MeSH-major] Lymphoma, Extranodal NK-T-Cell / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 19822485.001).
  • [ISSN] 1167-1122
  • [Journal-full-title] European journal of dermatology : EJD
  • [ISO-abbreviation] Eur J Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] France
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58. Miles RR, Afify Z, Yaish H, Perkins SL: CD56-negative extranodal nasal type NK/T-cell lymphoma. Pediatr Blood Cancer; 2010 Jul 15;55(1):186-9
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  • [Title] CD56-negative extranodal nasal type NK/T-cell lymphoma.
  • Extranodal natural killer (NK)/T-cell lymphoma, nasal type, is a rare lymphoma that occurs predominantly in Asian adults.
  • In this report, we describe the clinical and pathologic features of an unusual aggressive lymphoid neoplasm in a child and review the literature on NK/T-cell lymphoma in children.
  • This case represents an extranodal NK/T-cell lymphoma, nasal type, with an unusual lack of CD56.
  • [MeSH-major] Lymphoma, Extranodal NK-T-Cell / drug therapy

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  • (PMID = 20486184.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD56
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59. Kerl K, Prins C, Cerroni L, French LE: Regression of extranodal natural killer/T-cell lymphoma, nasal type with denileukin diftitox (Ontak) and bexarotene (Targretin): report of a case. Br J Dermatol; 2006 May;154(5):988-91
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  • [Title] Regression of extranodal natural killer/T-cell lymphoma, nasal type with denileukin diftitox (Ontak) and bexarotene (Targretin): report of a case.
  • We report a patient with rapidly progressive Epstein-Barr virus-positive nasal type extranodal natural killer/T-cell lymphoma (extranodal NKTCL), treated with a combination of denileukin diftitox (Ontak) and oral bexarotene (Targretin).
  • To our knowledge this is the first case of extranodal NKTCL treated with denileukin diftitox and bexarotene.
  • Combination treatment with denileukin diftitox and bexarotene should be further assessed in this aggressive type of cutaneous lymphoma.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Lymphoma, T-Cell, Cutaneous / drug therapy. Skin Neoplasms / drug therapy
  • [MeSH-minor] Diphtheria Toxin / administration & dosage. Fatal Outcome. Humans. Interleukin-2 / administration & dosage. Killer Cells, Natural / pathology. Male. Middle Aged. Recombinant Fusion Proteins / administration & dosage. Tetrahydronaphthalenes / administration & dosage

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  • (PMID = 16634908.001).
  • [ISSN] 0007-0963
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Diphtheria Toxin; 0 / Interleukin-2; 0 / Recombinant Fusion Proteins; 0 / Tetrahydronaphthalenes; 25E79B5CTM / denileukin diftitox; A61RXM4375 / bexarotene
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60. Seishima M, Yuge M, Kosugi H, Nagasaka T: Extranodal NK/T-cell lymphoma, nasal type, possibly arising from chronic Epstein-Barr virus infection. Acta Derm Venereol; 2010;90(1):102-3
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  • [Title] Extranodal NK/T-cell lymphoma, nasal type, possibly arising from chronic Epstein-Barr virus infection.
  • [MeSH-major] Epstein-Barr Virus Infections / complications. Lymphocytes / virology. Lymphoma, Extranodal NK-T-Cell / virology. Skin / virology
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biopsy. Chronic Disease. Diagnostic Errors. Fatal Outcome. Female. Humans. Immunophenotyping. Melkersson-Rosenthal Syndrome / diagnosis. Middle Aged. Treatment Failure

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  • (PMID = 20107744.001).
  • [ISSN] 1651-2057
  • [Journal-full-title] Acta dermato-venereologica
  • [ISO-abbreviation] Acta Derm. Venereol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Sweden
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61. Yu JB, Zuo Z, Tang Y, Zhao S, Zhang YC, Bi CF, Wang WY, Zhang WY, Wang L, Liu WP: Extranodal nasal-type natural killer/T-cell lymphoma of the skin: a clinicopathologic study of 16 cases in China. Hum Pathol; 2009 Jun;40(6):807-16
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  • [Title] Extranodal nasal-type natural killer/T-cell lymphoma of the skin: a clinicopathologic study of 16 cases in China.
  • Extranodal nasal-type natural killer/T-cell lymphoma presenting in skin, either primary or secondary, is relatively rare in China, accounting for about 4.1% of tumors.
  • Sixteen Chinese cases of cutaneous natural killer/T-cell lymphomas were investigated retrospectively by pathology, immunophenotype, genotype, Epstein-Barr virus status, and survival analysis.
  • In conclusion, both primary and secondary cutaneous natural killer/T-cell lymphomas are highly aggressive.
  • [MeSH-major] Lymphoma, T-Cell / pathology. Nose / pathology. Nose Neoplasms / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. China / epidemiology. Female. Humans. Killer Cells, Natural / pathology. Male. Middle Aged. Retrospective Studies

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  • (PMID = 19200574.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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62. Cobo F, Talavera P, Busquier H, Concha A: CNK/T-cell brain lymphoma associated with Epstein-Barr virus in a patient with AIDS. Neuropathology; 2007 Aug;27(4):396-402
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  • [Title] CNK/T-cell brain lymphoma associated with Epstein-Barr virus in a patient with AIDS.
  • We report a case of extranodal NK/T-cell lymphoma, nasal type, with exclusive cerebral localization in a patient with AIDS.
  • The patient presented with neurological alterations, fever and convulsions, so the initial presumptive diagnosis was an opportunistic brain infection.
  • MRI showed a left parietal necrotic lesion and a stereotactic brain biopsy was performed for pathological, microbiological and molecular studies.
  • Histological sections showed an angiocentric and angiodestructive growth pattern and the immunophenotype of this tumor was CD56+, CD45+, CD3+ (cytoplasmic), Granzyme B+ and Perforin+.
  • Also, a rearrangement study showed T-cell gene rearrangement with monoclonal appearance.
  • A diagnosis of extranodal NK/T-cell lymphoma was made and the patient died a few days later.
  • This case represents a very rare example of NK/T-cell lymphoma of the brain in a patient with AIDS.
  • The diagnosis of this kind of lymphomas requires a multimodality approach correlating clinical, morphological, immunophenotypic and molecular data.
  • [MeSH-major] Acquired Immunodeficiency Syndrome / complications. Epstein-Barr Virus Infections / complications. Killer Cells, Natural / pathology. Lymphoma, AIDS-Related / pathology. Lymphoma, T-Cell / pathology
  • [MeSH-minor] AIDS-Related Opportunistic Infections / pathology. Adult. Brain Neoplasms / genetics. Brain Neoplasms / metabolism. Brain Neoplasms / pathology. Brain Neoplasms / virology. Diagnosis, Differential. Gene Rearrangement, T-Lymphocyte. Hepatitis C / complications. Herpesvirus 4, Human / genetics. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Male. Polymerase Chain Reaction


63. Ishida F, Kwong YL: Diagnosis and management of natural killer-cell malignancies. Expert Rev Hematol; 2010 Oct;3(5):593-602
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  • [Title] Diagnosis and management of natural killer-cell malignancies.
  • Natural killer (NK)-cell malignancies are uncommon neoplasms, which have been referred to as polymorphic reticulosis or angiocentric T-cell lymphomas in the past.
  • In the current WHO classification, they are categorized as extranodal NK/T-cell lymphoma, nasal type and aggressive NK-cell leukemia.
  • NK-cell malignancies show a geographical predilection for Asian and South American populations and are rare in the west.
  • Pathologically, NK-cell lymphomas show a polymorphic neoplastic infiltrate with angioinvasion and angiodestruction.
  • The lymphoma cells are CD2(+), cytoplasmic CD3ε(+) and CD56(+), with germline T-cell receptor gene.
  • Clinically, NK-cell lymphomas can be classified into nasal, non-nasal and aggressive lymphoma/leukemia subtypes.
  • Most nasal NK-cell lymphomas present with stage I/II disease.
  • Chemotherapy is indicated for stage III/IV nasal NK-cell lymphoma, and the non-nasal and aggressive subtypes.
  • High-dose chemotherapy and hematopoietic stem-cell transplantation with autologous or allogeneic hematopoietic stem cells may be beneficial to selected patients.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Asparaginase / administration & dosage. Killer Cells, Natural / drug effects. Leukemia / diagnosis. Leukemia / therapy. Lymphoma, Extranodal NK-T-Cell / diagnosis. Lymphoma, Extranodal NK-T-Cell / therapy
  • [MeSH-minor] Antigens, CD. Asia / epidemiology. Female. Hematopoietic Stem Cell Transplantation. Herpesvirus 4, Human. Humans. Male. Middle Aged. Prognosis. Recurrence. Severity of Illness Index. South America / epidemiology. Transplantation, Autologous

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  • (PMID = 21083476.001).
  • [ISSN] 1747-4094
  • [Journal-full-title] Expert review of hematology
  • [ISO-abbreviation] Expert Rev Hematol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD; EC 3.5.1.1 / Asparaginase
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64. Chang BH, Stork L, Fan G: A unique case of adolescent CD56-negative extranodal NK/T-cell lymphoma, nasal type. Pediatr Dev Pathol; 2008 Jan-Feb;11(1):50-4
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  • [Title] A unique case of adolescent CD56-negative extranodal NK/T-cell lymphoma, nasal type.
  • Mature T-cell neoplasms are unusual in the pediatric population.
  • The majority of these neoplasms in the United States are anaplastic large cell lymphomas (ALCL) characterized by CD30 and anaplastic lymphoma kinase-1 expression.
  • Extranodal natural killer/T (NK/T)-cell lymphomas, nasal type, are extremely rare.
  • Extranodal NK/T-cell lymphomas often express CD56, are associated with Epstein-Barr virus, and are negative for CD30.
  • Clinically, extranodal NK/T-cell lymphomas are much more aggressive than ALCL, and require different treatment strategies.
  • The authors present an adolescent male with a CD56 negative extranodal NK/T-cell lymphoma, nasal type.
  • The lymphoma was partially positive for CD30, diffusely positive for EBV by in situ hybridization, and clonal for T-cell receptor gene rearrangement and cytogenetic abnormalities.
  • This case highlights the importance and difficulty of accurate identification of this type of rare tumor.
  • We further present the literature review and discuss the diagnostic criteria for extranodal NK/T lymphoma using morphologic, immunologic, molecular, and cytogenetic information.
  • [MeSH-major] Antigens, CD56 / metabolism. Lymphoma, Extranodal NK-T-Cell / diagnosis. Lymphoma, Large-Cell, Anaplastic / diagnosis
  • [MeSH-minor] Adolescent. Antigens, CD30 / metabolism. Chromosome Aberrations. Diagnosis, Differential. Gene Rearrangement. Herpesvirus 4, Human / isolation & purification. Humans. In Situ Hybridization. Male. Nose / pathology. Receptors, Antigen, T-Cell / genetics

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  • [CommentIn] Pediatr Dev Pathol. 2008 Jul-Aug;11(4):325; author reply 326 [18839448.001]
  • (PMID = 18237230.001).
  • [ISSN] 1093-5266
  • [Journal-full-title] Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
  • [ISO-abbreviation] Pediatr. Dev. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD30; 0 / Antigens, CD56; 0 / Receptors, Antigen, T-Cell
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65. Reyes VE Jr, Al-Saleem T, Robu VG, Smith MR: Extranodal NK/T-cell lymphoma nasal type: efficacy of pegaspargase. Report of two patients from the United Sates and review of literature. Leuk Res; 2010 Jan;34(1):e50-4
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  • [Title] Extranodal NK/T-cell lymphoma nasal type: efficacy of pegaspargase. Report of two patients from the United Sates and review of literature.

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  • (PMID = 19786301.001).
  • [ISSN] 1873-5835
  • [Journal-full-title] Leukemia research
  • [ISO-abbreviation] Leuk. Res.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA006927-44; United States / NCI NIH HHS / CA / P30 CA006927; United States / NCI NIH HHS / CA / CA06927; United States / NCI NIH HHS / CA / P30 CA006927-44
  • [Publication-type] Case Reports; Letter; Research Support, N.I.H., Extramural; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / pegaspargase; 30IQX730WE / Polyethylene Glycols; EC 3.5.1.1 / Asparaginase
  • [Number-of-references] 33
  • [Other-IDs] NLM/ NIHMS144531; NLM/ PMC2813903
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66. Zhao S, Liu WP, Wang XL, Zhang WY, Jiang W, Tang Y, Li GD: [Detection of the 30 base pair deletion of Epstein-Barr virus latent membrane protein 1 in extranodal nasal type NK/T-cell lymphoma and its prognostic significance]. Zhonghua Bing Li Xue Za Zhi; 2005 Nov;34(11):720-3
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  • [Title] [Detection of the 30 base pair deletion of Epstein-Barr virus latent membrane protein 1 in extranodal nasal type NK/T-cell lymphoma and its prognostic significance].
  • OBJECTIVE: To compare the detection rate of Epstein-Barr virus latent membrane protein 1 (LMP1) 30 base pair deletion in extranodal nasal type NK/T-cell lymphoma with that in chronic inflammation of nasopharynx and tonsillitis; and to analyze the prognostic significance of LMP1 deletion in extranodal nasal type NK/T-cell lymphoma.
  • METHODS: Polymerase chain reaction was used to detect the deletion of LMP1 in 55 cases of extranodal nasal type NK/T-cell lymphoma and 19 cases of chronic inflammation of nasopharynx and tonsillitis.
  • RESULTS: In all the 55 extranodal nasal type NK/T-cell lymphoma cases studied, 9 cases contained the wide-type or predominantly wide-type LMP1.
  • In the non-lymphoma control group, 16 cases contained the deleted or predominantly deleted LMP1.
  • However, no statistically significant difference was found in the detection rate of 30 base pair deleted LMP1 between extranodal nasal type NK/T-cell lymphoma and control group (P > 0.05).
  • The prognosis of deleted or predominantly deleted LMP1 in extranodal nasal type NK/T-cell lymphoma was worse.
  • CONCLUSION: Though 30 base pair deletion of Epstein-Barr virus LMP1 may not be an important pathogenetic step in extranodal nasal type NK/T-cell lymphoma, it may play some role in tumor progression.
  • [MeSH-major] Lymphoma, T-Cell, Peripheral / genetics. Nose Neoplasms / genetics. Sequence Deletion. Viral Matrix Proteins / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Base Sequence. Epstein-Barr Virus Infections / genetics. Epstein-Barr Virus Infections / virology. Female. Follow-Up Studies. Herpesvirus 4, Human / genetics. Humans. Killer Cells, Natural / pathology. Killer Cells, Natural / virology. Male. Middle Aged. Nasopharyngitis. Survival Rate. Tonsillitis / genetics. Tonsillitis / virology

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  • (PMID = 16536316.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / EBV-associated membrane antigen, Epstein-Barr virus; 0 / Viral Matrix Proteins
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67. Oshimi K: Progress in understanding and managing natural killer-cell malignancies. Br J Haematol; 2007 Nov;139(4):532-44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Progress in understanding and managing natural killer-cell malignancies.
  • The World Health Organization classification of haematolymphoid tumours recognizes three categories of natural killer (NK)-cell neoplasms: blastic NK-cell lymphoma, aggressive NK-cell leukaemia, and extranodal NK/T-cell lymphoma, nasal-type.
  • Recent studies indicate that CD4+CD56+ blastic NK-cell lymphoma is of plasmacytoid dendritic cell origin, and true tumours of precursor NK-cell origin may be present mainly in the CD4-CD56+ subset.
  • Myeloid/NK-cell precursor acute leukaemia may also develop from precursor NK cells.
  • However, because the developmental pathway of normal NK cells is not well understood, tumours of precursor NK-cell origin are not clearly identified.
  • Among mature NK-cell tumours, extranodal NK/T-cell lymphoma is relatively common in Asia and Latin America.
  • Aggressive NK-cell leukaemia is rare and has a poor prognosis.
  • Because NK-cell neoplasms are rare and difficult to manage, rigorous studies are required for their understanding and management.
  • [MeSH-major] Killer Cells, Natural / pathology. Leukemia, Lymphoid / therapy
  • [MeSH-minor] Acute Disease. Cell Lineage. Cell Transformation, Neoplastic / pathology. Chronic Disease. Humans. Neoplasm Staging. Preleukemia / pathology. Prognosis

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  • (PMID = 17916099.001).
  • [ISSN] 1365-2141
  • [Journal-full-title] British journal of haematology
  • [ISO-abbreviation] Br. J. Haematol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Number-of-references] 132
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68. Dominguez-Malagon H, Mosqueda-Taylor A, Cano-Valdez AM: Necrotizing sialometaplasia of the palate associated with angiocentric T-cell lymphoma. Ann Diagn Pathol; 2009 Feb;13(1):60-4
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  • [Title] Necrotizing sialometaplasia of the palate associated with angiocentric T-cell lymphoma.
  • In this article we present 2 cases of necrotizing sialometaplasia (NS) associated with angiocentric lymphoma of the midline.
  • Immunohistochemical analysis confirmed a T-cell origin, and in situ hybridization in one case revealed its relationship to Epstein-Barr virus.
  • To our knowledge, the association between angiocentric lymphoma and NS has been previously reported in only one instance, and we suggest that this particular type of lymphoma should be added to the list of related conditions for NS.
  • [MeSH-major] Epstein-Barr Virus Infections / complications. Lymphoma, T-Cell / complications. Palatal Neoplasms / complications. Paranasal Sinus Neoplasms / complications. Sialometaplasia, Necrotizing / diagnosis. Sialometaplasia, Necrotizing / etiology

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  • (PMID = 19118785.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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69. Al-Hakeem DA, Fedele S, Carlos R, Porter S: Extranodal NK/T-cell lymphoma, nasal type. Oral Oncol; 2007 Jan;43(1):4-14
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extranodal NK/T-cell lymphoma, nasal type.
  • Extranodal NK/T-cell lymphoma, nasal type (ENKTCL), previously known as lethal midline granuloma is a distinct clinico-pathological entity associated with Epstein-Barr virus that typically causes destruction of the midface, palatal and orbital walls.
  • ENKTCL neoplastic cells express some T-cell associated antigens, most commonly CD2 and cytoplasmic CD3epsilon and, in favour of an NK-cell origin, CD56.
  • [MeSH-major] Granuloma, Lethal Midline / pathology. Lymphoma, T-Cell / pathology

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  • (PMID = 17064952.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 142
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70. Chorianopoulos D, Samitas K, Vittorakis S, Kiriazi V, Rondoyianni D, Tsaousis G, Skoutelis A: Extranodal natural killer/T-cell lymphoma, nasal-type. Skinmed; 2010 Jan-Feb;8(1):56-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extranodal natural killer/T-cell lymphoma, nasal-type.
  • His medical history was remarkable for nasal polyps, which were surgically removed 15 years earlier.
  • CT of the brai and sinonasal area revealed an abnormal low-density mass in the left nasal area.
  • CT findings of the abdomen were negative, as were results of a bone marrow biopsy.
  • The differential diagnosis, considering the evidence described, included granulomatous or infectious diseases, angiocentric lymphoproliferative lesions, and lymphomas.
  • Biopsy of a skin lesion showed lymphoproliferative infiltration of the dermis with a follicular and angiocentric growth pattern and regional epidermal necrosis.
  • Immunohistochemical stains showed that the tumor cell were positive for CD56 and CD3 (cytoplasmic positivity) and expressed the cytotoxic proteins T-cell intracellular antigen and granzyme B (Figure 3) They lacked TdT, CD34, CD7, CD8, TCL-1, and CD123.
  • Give this result, molecular analysis ofT-cell receptor (TCR) gene rearrangements was performed using polymerase chain reaction-based TCR-gamma gene, wit negative results.
  • The morphology and the immunophenotype were consistent with natural killer/T-cell lymphoma, nasal-type.
  • Nasal involvement must be first excluded to proceed to the diagnosis of nasal-type natural killer-cell lymphoma.
  • Indeed, histologic examination of the nasal mass revealed its polypoid nature.
  • Thus, the authors were led to the diagnosis of extranodal extranasal natural killer/T-cell lymphoma, nasal-type, CD56-positive, Ep stein-Barr virus-negative, TCR-negative.
  • [MeSH-major] Lymphoma, Extranodal NK-T-Cell / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Fatal Outcome. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 20839428.001).
  • [ISSN] 1540-9740
  • [Journal-full-title] Skinmed
  • [ISO-abbreviation] Skinmed
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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71. Drut R, Drut RM: Angiocentric immunoproliferative lesion and angiocentric lymphoma of lymph node in children. A report of two cases. J Clin Pathol; 2005 May;58(5):550-2
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  • [Title] Angiocentric immunoproliferative lesion and angiocentric lymphoma of lymph node in children. A report of two cases.
  • AIM: To report two examples of an angiocentric immunoproliferative lesion (AIL) and angiocentric angiodestructive lymphoma (AL) presenting in lymph nodes in children.
  • Most commonly involving extranodal sites, AIL/AL rarely presents in the spleen and lymph nodes.
  • METHODS/RESULTS: Case 1 presented as a cervical lymphadenopathy in a 3 year old girl being treated for pre-B cell acute lymphoblastic leukaemia.
  • Histological and immunohistochemistry studies revealed an Epstein-Barr virus positive (EBV+), large B cell (CD20 and CD30+) AIL with large areas of necrosis, the whole resembling lymphomatoid granulomatosis.
  • Histology and immunohistochemistry revealed an EBV-, large T cell (CD45RO, CD56, and CD30+) AL, presenting the features of so called angiocentric T cell/natural killer cell lymphoma, nasal type.
  • CONCLUSIONS: The term AIL/AL refers to a heterogeneous group of conditions not unique to a particular type of lymphoid cell.
  • These lesions are easily recognised by the histopathologist because of their extremely unusual angiocentric pattern.
  • [MeSH-major] Immunoproliferative Disorders / pathology. Lymph Nodes / pathology. Lymphatic Diseases / pathology. Lymphoma, T-Cell / pathology

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  • (PMID = 15858132.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1770650
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72. Ito T, Okubo Y, Furuhata Y, Niide M, Kawaguchi A, Yamazaki M, Iwaya K, Tsuboi R: Extranodal NK/T-cell lymphoma, nasal type, presenting after 5 years of remission. Int J Dermatol; 2008 Mar;47(3):259-61
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  • [Title] Extranodal NK/T-cell lymphoma, nasal type, presenting after 5 years of remission.
  • [MeSH-major] Epstein-Barr Virus Infections / complications. Killer Cells, Natural. Lymphoma, T-Cell / pathology. Skin / pathology. Skin Neoplasms / pathology

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  • (PMID = 18289327.001).
  • [ISSN] 1365-4632
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Viral; 0 / RNA, Viral
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73. Kishimoto K, Kitamura T, Hirayama Y, Tate G, Mitsuya T: Three cases of extranodal NK/T-cell lymphoma of the nasal type diagnosed by nasal brush cytology. Diagn Cytopathol; 2007 Feb;35(2):125-9
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  • [Title] Three cases of extranodal NK/T-cell lymphoma of the nasal type diagnosed by nasal brush cytology.
  • Extranodal natural killer (NK)/T-cell lymphoma of the nasal type is a rare type of malignant lymphoma that is most common in Asian countries.
  • Here we describe cytomorphologic, immunocytochemical, and molecular cytochemical features of three cases of NK/T-cell lymphoma of the nasal type diagnosed by nasal brush cytology.
  • Cytomorphologic findings common among the three cases included the presence of several cell types, including nasal cavity epithelial cells, histiocytes, phagocytic histiocytes, and lymphoid cells, within a necrotic background.
  • Suspected lymphoma cells were medium to large lymphoid cells possessing light blue and abundant cytoplasm.
  • We believe these intriguing cytologic findings are indicators of NK/T-cell lymphoma of the nasal type.
  • Immunocytochemical and molecular cytochemical analyses showed staining for natural killer cell antigen CD56 as well as cytotoxic granule-associated proteins granzyme B7 (GrB7) and T-cell-restricted intercellular antigen-1 (TIA-1).
  • Comparison between cytobrush and cotton swab methodology showed that cytobrush resulted in more cell-rich specimens than did cotton swabs, suggesting that nasal brush cytology with cytobrush is most useful in the diagnosis of NK/T-cell lymphoma of the nasal type.
  • [MeSH-major] Killer Cells, Natural / pathology. Lymphoma, T-Cell / diagnosis. Nose Neoplasms / diagnosis

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  • (PMID = 17230578.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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74. Lee J, Park YH, Kim WS, Lee SS, Ryoo BY, Yang SH, Park KW, Kang JH, Park JO, Lee SH, Kim K, Jung CW, Park YS, Im YH, Kang WK, Lee MH, Ko YH, Ahn YC, Park K: Extranodal nasal type NK/T-cell lymphoma: elucidating clinical prognostic factors for risk-based stratification of therapy. Eur J Cancer; 2005 Jul;41(10):1402-8
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  • [Title] Extranodal nasal type NK/T-cell lymphoma: elucidating clinical prognostic factors for risk-based stratification of therapy.
  • The purpose of this study was to define distinctive clinical features of "nasal" and "nasal-type" NK/T cell lymphomas by assessing prognostic factors.
  • The anatomic definition of extranasal NK/T cell lymphoma has been vague resulting in variable definitions of extranasal sites by different groups.
  • We analysed the clinical behavior of 90 NK/T cell lymphoma patients and attempted to elucidate the prognostic factors for risk-based stratification of therapy.
  • We observed no significant difference between "nasal" and "nasal-type" NK/T cell lymphomas in regards to clinical features and survival using the conventional anatomic classification.
  • We suggest the categorisation of the two subtypes of NK/T cell lymphoma as follows: UNKTL (upper aerodigestive tract NK/T cell lymphoma) including all lymphomas confined to nasal cavity, nasopharynx, and the upper aerodigestive tract and EUNKTL (extra-upper aerodigestive tract NK/T cell lymphoma) group to include all sites other than the UNKTL group.
  • The EUNKTL group in this study had advanced stage at diagnosis, higher LDH, higher IPI score, poorer performance and inferior response to the anthracycline-based chemotherapy with statistical significance.
  • [MeSH-major] Killer Cells, Natural / pathology. Lymphoma, T-Cell / pathology. Nose Neoplasms / pathology

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  • (PMID = 15963893.001).
  • [ISSN] 0959-8049
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
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75. Frank MC, Bono E, Sun T: An unusual case of peripheral T-cell lymphoma with CD56 positivity and angiocentric, angiodestructive morphology arising in the ileum. Arch Pathol Lab Med; 2005 Apr;129(4):527-30
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  • [Title] An unusual case of peripheral T-cell lymphoma with CD56 positivity and angiocentric, angiodestructive morphology arising in the ileum.
  • Natural killer cell and cytotoxic T-cell lymphomas are frequently difficult to distinguish because they share many common features, and yet it is important to make an accurate diagnosis because their prognoses differ.
  • We report an unusual case of a white man with a CD56-positive T-cell lymphoma in the ileum.
  • Immunohistochemical staining showed positive reactions to CD3, CD8, CD43, CD45RO, CD56, and T-cell intracellular antigen-1, but negative reactions to CD4, CD5, CD20, CD23, and CD57.
  • The T-cell receptor gamma chain gene was rearranged.
  • According to the World Health Organization classification, the absence of EBV excludes the diagnosis of extranodal natural killer/T-cell lymphoma, nasal type.
  • However, the association of EBV with this lymphoma in white patients is not clear.
  • Therefore, absence of EBV alone does not necessarily exclude nasal-type natural killer/T-cell lymphoma, particularly because the histologic pattern in this case is highly characteristic of this tumor.
  • [MeSH-major] Ileal Neoplasms / pathology. Lymphoma, T-Cell, Peripheral / pathology
  • [MeSH-minor] Aged. Antigens, CD56 / metabolism. Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor. Humans. Immunohistochemistry. Male. Neovascularization, Pathologic

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  • (PMID = 15794680.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD56
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76. Lozzi GP, Massone C, Citarella L, Kerl H, Cerroni L: Rimming of adipocytes by neoplastic lymphocytes: a histopathologic feature not restricted to subcutaneous T-cell lymphoma. Am J Dermatopathol; 2006 Feb;28(1):9-12
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  • [Title] Rimming of adipocytes by neoplastic lymphocytes: a histopathologic feature not restricted to subcutaneous T-cell lymphoma.
  • Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare cytotoxic T-cell lymphoma of the skin presenting with histopathologic features simulating those of a lobular panniculitis.
  • The presence of neoplastic T-lymphocytes forming a rim around the individual fat cells in the subcutaneous lobules, so-called "rimming" of adipocytes, is considered a characteristic morphologic feature of this type of cutaneous lymphoma.
  • In this study we reviewed a series of 45 biopsy specimens of primary and secondary cutaneous B- and T-cell lymphomas and one of myeloid leukemia involving the subcutaneous tissues and showing rimming of adipocytes (subcutaneous panniculitis-like T-cell lymphoma: n = 16; mycosis fungoides, tumor stage: n = 3; aggressive epidermotropic CD8(+) T-cell lymphoma: n = 2; cutaneous gamma/delta T-cell lymphoma: n = 4; extranodal NK/T-cell lymphoma, nasal type: n = 4; cutaneous medium-large pleomorphic T-cell lymphoma, NOS: n = 5; CD4(+)/CD56(+) hematodermic neoplasm (blastic NK-cell lymphoma): n = 7; secondary cutaneous large B-cell lymphoma: n = 3; secondary cutaneous lymphoplasmacytic lymphoma: n = 1; specific cutaneous manifestations of acute myelogenous leukemia: n = 1).
  • We could demonstrate that rimming of adipocytes by neoplastic cells can be recognized not only in subcutaneous panniculitis-like T-cell lymphoma, but also in several different entities of malignant lymphoma with skin involvement.
  • Rimming of adipocytes should not be considered specific of subcutaneous panniculitis-like T-cell lymphoma.
  • [MeSH-major] Adipocytes / pathology. Lymphoma, B-Cell / pathology. Lymphoma, T-Cell / pathology. Skin Neoplasms / pathology. T-Lymphocytes / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Female. Gene Rearrangement. Genes, T-Cell Receptor gamma / genetics. Humans. Immunoglobulin Heavy Chains / genetics. Male. Middle Aged. Panniculitis / metabolism. Panniculitis / pathology. Receptors, Antigen, T-Cell, gamma-delta / genetics. Receptors, Antigen, T-Cell, gamma-delta / metabolism

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  • (PMID = 16456318.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Immunoglobulin Heavy Chains; 0 / Receptors, Antigen, T-Cell, gamma-delta
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77. Yokoyama H, Yamamoto J, Tohmiya Y, Yamada MF, Ohguchi H, Ohnishi Y, Okitsu Y, Fukuhara N, Ohba-Ohtsuka R, Kohata K, Ishizawa K, Kameoka J, Harigae H: Allogeneic hematopoietic stem cell transplant following chemotherapy containing l-asparaginase as a promising treatment for patients with relapsed or refractory extranodal natural killer/T cell lymphoma, nasal type. Leuk Lymphoma; 2010 Aug;51(8):1509-12
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  • [Title] Allogeneic hematopoietic stem cell transplant following chemotherapy containing l-asparaginase as a promising treatment for patients with relapsed or refractory extranodal natural killer/T cell lymphoma, nasal type.
  • The prognosis of advanced extranodal NK/T cell lymphoma (ENKTL) is poor.
  • Allogeneic hematopoietic stem cell transplant (allo-HSCT) has been suggested to be a promising treatment for this disease, but its utility has yet to be established.
  • [MeSH-major] Asparaginase / therapeutic use. Drug Resistance, Neoplasm. Graft vs Host Disease / prevention & control. Hematopoietic Stem Cell Transplantation. Lymphoma, T-Cell / therapy. Natural Killer T-Cells / pathology. Nose Neoplasms / therapy

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  • (PMID = 20496989.001).
  • [ISSN] 1029-2403
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Immunosuppressive Agents; 83HN0GTJ6D / Cyclosporine; EC 3.5.1.1 / Asparaginase; YL5FZ2Y5U1 / Methotrexate
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78. Willemze R, Meijer CJ: Classification of cutaneous T-cell lymphoma: from Alibert to WHO-EORTC. J Cutan Pathol; 2006 Feb;33 Suppl 1:18-26
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  • [Title] Classification of cutaneous T-cell lymphoma: from Alibert to WHO-EORTC.
  • Cutaneous T-cell lymphomas (CTCLs) represent a heterogeneous group of neoplasms originating from skin-homing T cells that show considerable variation in clinical presentation, histological appearance, immuno- phenotype, and prognosis.
  • This review provides a historic overview of the classification of CTCLs from the first description of a patient with mycosis fungoides in 1806 to the recently published WHO-EORTC classification.
  • Practical guidelines for the usage of the WHO-EORTC classification and relevant features of new or newly defined entities such as subcutaneous panniculitis-like T-cell lymphoma, extranodal NK/T-cell lymphoma, nasal type, primary cutaneous aggressive CD8-positive cytotoxic T-cell lymphoma, and cutaneous gamma/delta T-cell lymphoma are presented.
  • The aim of this review is to contribute to a better communication between dermatologist and pathologist and in this way to a better diagnosis and classification of CTCLs.
  • [MeSH-major] Lymphoma, T-Cell, Cutaneous / classification. Lymphoma, T-Cell, Cutaneous / diagnosis. Skin Neoplasms / classification. Skin Neoplasms / diagnosis

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  • (PMID = 16412209.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Denmark
  • [Number-of-references] 40
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79. Abouyabis AN, Shenoy PJ, Lechowicz MJ, Flowers CR: Incidence and outcomes of the peripheral T-cell lymphoma subtypes in the United States. Leuk Lymphoma; 2008 Nov;49(11):2099-107
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  • [Title] Incidence and outcomes of the peripheral T-cell lymphoma subtypes in the United States.
  • Peripheral T-cell lymphomas (PTCL) represent a small subgroup of non-Hodgkin lymphomas historically difficult to diagnose.
  • Asian predominance was pronounced for extranodal NK/T-cell lymphoma, nasal type.
  • [MeSH-major] Lymphoma, T-Cell, Peripheral / epidemiology

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  • [CommentIn] Leuk Lymphoma. 2008 Nov;49(11):2033-4 [19021043.001]
  • (PMID = 19021052.001).
  • [ISSN] 1029-2403
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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80. Wang J, Geng SA, Su Z, Xu J, Xu S, Wang F, Mo X, Feng Z: Rearranged T-cell receptor gene and positive Epstein-Barr virus-encoded nuclear RNA in an extranodal NK/T-cell lymphoma with cutaneous manifestation only: case study. Clin Exp Dermatol; 2007 Nov;32(6):744-8
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  • [Title] Rearranged T-cell receptor gene and positive Epstein-Barr virus-encoded nuclear RNA in an extranodal NK/T-cell lymphoma with cutaneous manifestation only: case study.
  • Natural killer (NK)/cytotoxic T-cell lymphoma, a new type of cutaneous neoplasm, has been described recently in the World Health Organization/European Organization for Research and Treatment of Cancer classification for cutaneous lymphomas.
  • Routine clinical and laboratory examinations found no primary nasal involvement.
  • Biopsies taken from nasal mucosa and skin showed that the tumour only involved dermis and subcutaneous tissue, and the infiltrated lymphohistiocytic tumour cells were CD56+, TIA+, CD45RO+ and CD30+.
  • Clonal T-cell receptor-gamma2 gene rearrangement was positive.
  • A diagnosis of extranodal NK/T-cell lymphoma, nasal type, was made.
  • [MeSH-major] Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor. Lymphoma, Extranodal NK-T-Cell / pathology. Lymphoma, T-Cell, Cutaneous / pathology. RNA-Binding Proteins / analysis. Ribosomal Proteins / analysis. Skin Neoplasms / pathology

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  • (PMID = 17953643.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / RNA-Binding Proteins; 0 / Ribosomal Proteins; 135844-68-7 / RPL22 protein, human
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81. Chow C, Liu AY, Chan WS, Lei KI, Chan WY, Lo AW: AKT plays a role in the survival of the tumor cells of extranodal NK/T-cell lymphoma, nasal type. Haematologica; 2005 Feb;90(2):274-5
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  • [Title] AKT plays a role in the survival of the tumor cells of extranodal NK/T-cell lymphoma, nasal type.
  • Phosphorylated AKT has been detected in extranodal NK/T-cell lymphoma, nasal type (ENTL).
  • Either interleukin-2 (IL-2) or interleukin-15 (IL-15) could prevent AKT dephosphorylation and apoptosis in the NK-92 cell line model.
  • [MeSH-major] Killer Cells, Natural / cytology. Lymphoma, T-Cell / immunology. Nose Neoplasms / immunology. Proto-Oncogene Proteins c-akt / physiology
  • [MeSH-minor] Cell Line, Tumor. Cell Survival. Humans. Immunohistochemistry. Immunophenotyping. Interleukin-15 / blood. Interleukin-15 / metabolism. Interleukin-2 / metabolism. Lymphoma / pathology. Phosphorylation

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  • (PMID = 15710591.001).
  • [ISSN] 1592-8721
  • [Journal-full-title] Haematologica
  • [ISO-abbreviation] Haematologica
  • [Language] eng
  • [Publication-type] Letter; Research Support, Non-U.S. Gov't
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Interleukin-15; 0 / Interleukin-2; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt
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82. Lee J, Suh C, Huh J, Jun HJ, Kim K, Jung C, Park K, Park YH, Ko YH, Kim WS: Effect of positive bone marrow EBV in situ hybridization in staging and survival of localized extranodal natural killer/T-cell lymphoma, nasal-type. Clin Cancer Res; 2007 Jun 1;13(11):3250-4
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  • [Title] Effect of positive bone marrow EBV in situ hybridization in staging and survival of localized extranodal natural killer/T-cell lymphoma, nasal-type.
  • PURPOSE: The aim of the study was to determine the effect of EBV-encoded RNA-1 in situ hybridization (EBER-1 ISH) in bone marrow specimens on survival outcome in patients with clinical stage I/II natural killer/T-cell lymphoma.
  • EXPERIMENTAL DESIGN: We systematically did EBER-1 ISH on 182 archival bone marrow tissues from 91 patients who were diagnosed of stage I/II natural killer/T-cell lymphoma and analyzed the correlation between bone marrow EBER-1 ISH status and survival.
  • [MeSH-major] Bone Marrow / virology. Epstein-Barr Virus Infections / complications. Herpesvirus 4, Human / metabolism. Lymphoma, T-Cell / mortality. Lymphoma, T-Cell / virology. Nasopharyngeal Neoplasms / mortality. Nasopharyngeal Neoplasms / virology. Neoplasm Staging / methods
  • [MeSH-minor] Aged. Antigens, CD3 / biosynthesis. Bone Marrow Cells / metabolism. Female. Humans. In Situ Hybridization. Killer Cells, Natural / metabolism. Killer Cells, Natural / virology. Male. Middle Aged

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  • (PMID = 17545530.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD3
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83. Paik YS, Liess BD, Scheidt TD, Ingram EA, Zitsch RP 3rd: Extranodal nasal-type natural killer/T-cell lymphoma masquerading as recalcitrant sinusitis. Head Neck; 2010 Feb;32(2):268-73
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  • [Title] Extranodal nasal-type natural killer/T-cell lymphoma masquerading as recalcitrant sinusitis.
  • BACKGROUND: Extranodal nasal-type natural killer (NK)/T-cell lymphoma is a very uncommon disease process often mimicking refractory sinusitis.
  • The diagnosis may be discovered after an extensive exclusion process.
  • Careful immunohistochemical evaluation is crucial to differentiate NK/T-cell lymphoma from other malignancies.
  • Immunohistopathology demonstrated extranodal nasal-type NK/T-cell lymphoma.
  • CONCLUSION: Severe recalcitrant sinusitis with orbital involvement may be the initial presentation of NK/T-cell lymphoma.
  • In addition to radiographic and laboratory testing, large biopsies should be taken for immunohistochemical analysis to achieve diagnosis and guide further management.
  • [MeSH-major] Lymphoma, Extranodal NK-T-Cell / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Facial Pain / etiology. Facial Paralysis / etiology. Fatal Outcome. Hearing Loss, Conductive / etiology. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Necrosis. Sinusitis / diagnosis. Tomography, X-Ray Computed. Vision Disorders / etiology. Visual Fields

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  • [Copyright] Copyright 2009 Wiley Periodicals, Inc.
  • (PMID = 19360743.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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84. Vega F, Lin P, Medeiros LJ: Extranodal lymphomas of the head and neck. Ann Diagn Pathol; 2005 Dec;9(6):340-50
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  • [Title] Extranodal lymphomas of the head and neck.
  • Malignant lymphomas represent approximately 5% of all malignant neoplasms of the head and neck and may involve nodal or extranodal sites.
  • Nodal head and neck lymphomas are similar to other nodal sites and are not further reviewed here.
  • The head and neck region is the second most frequent anatomical site of extranodal lymphomas (after the gastrointestinal tract).
  • Most are non-Hodgkin's lymphomas of B-cell lineage, and overall diffuse large B-cell lymphoma is the most common type.
  • Hodgkin's lymphoma rarely occurs in extranodal sites.
  • Other hematologic neoplasms that commonly involve extranodal sites of the head and neck are also discussed.
  • In this review, we begin by discussing lymphomas involving the head and neck according to anatomical site.
  • Then we discuss specifically the pathological findings of extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue, plasmablastic lymphoma, extramedullary plasmacytoma, and extranodal natural killer/T-cell lymphoma of nasal type.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Lymphoma / pathology
  • [MeSH-minor] Humans. Killer Cells, Natural. Lymphoma, B-Cell / pathology. Lymphoma, B-Cell, Marginal Zone / pathology. Lymphoma, T-Cell / pathology. Plasmacytoma / pathology

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  • (PMID = 16308165.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 79
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85. Huang JJ, Li HR, Huang Y, Jiang WQ, Xu RH, Huang HQ, Lv Y, Xia ZJ, Zhu XF, Lin TY, Li ZM: Beclin 1 expression: a predictor of prognosis in patients with extranodal natural killer T-cell lymphoma, nasal type. Autophagy; 2010 Aug;6(6):777-83
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  • [Title] Beclin 1 expression: a predictor of prognosis in patients with extranodal natural killer T-cell lymphoma, nasal type.
  • The function and expression of Beclin 1 in natural killer T-cell lymphoma is largely unexplored.
  • The study aimed to investigate Beclin 1 expression and its relationship with prognosis in extranodal natural killer T-cell lymphoma, nasal type (EN KL).
  • [MeSH-major] Apoptosis Regulatory Proteins / metabolism. Lymphoma, Extranodal NK-T-Cell / diagnosis. Lymphoma, Extranodal NK-T-Cell / metabolism. Membrane Proteins / metabolism. Nose Neoplasms / diagnosis. Nose Neoplasms / metabolism

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  • (PMID = 20639699.001).
  • [ISSN] 1554-8635
  • [Journal-full-title] Autophagy
  • [ISO-abbreviation] Autophagy
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Apoptosis Regulatory Proteins; 0 / BECN1 protein, human; 0 / Membrane Proteins
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86. Schubert S, Abdul-Khaliq H, Lehmkuhl HB, Yegitbasi M, Reinke P, Kebelmann-Betzig C, Hauptmann K, Gross-Wieltsch U, Hetzer R, Berger F: Diagnosis and treatment of post-transplantation lymphoproliferative disorder in pediatric heart transplant patients. Pediatr Transplant; 2009 Feb;13(1):54-62
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  • [Title] Diagnosis and treatment of post-transplantation lymphoproliferative disorder in pediatric heart transplant patients.
  • It was diagnosed in 7/12 as a monomorphic B-cell lymphoma and in four patients as a monomorphic Burkitt lymphoma, a polymorphic B-cell lymphoma, a T-cell rich or angiocentric lymphoma (Liebow) and as reactive plasmacytic hyperplasia (early lesion), respectively.
  • Despite reduction of immunosuppression, treatment consisted of surgical procedures to remove tumor masses (n = 6), Rituximab (n = 5), polychemotherapy (n = 3), antiviral (n = 1) and autologous T-cell therapy (n = 1).
  • The manifestation of PTLD in pediatric heart transplant recipients is associated with EBV infection and is predominantly in the form of a B-cell lymphoma.
  • [MeSH-major] Heart Transplantation / adverse effects. Lymphoproliferative Disorders / diagnosis


87. Schwartz EJ, Molina-Kirsch H, Zhao S, Marinelli RJ, Warnke RA, Natkunam Y: Immunohistochemical characterization of nasal-type extranodal NK/T-cell lymphoma using a tissue microarray: an analysis of 84 cases. Am J Clin Pathol; 2008 Sep;130(3):343-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistochemical characterization of nasal-type extranodal NK/T-cell lymphoma using a tissue microarray: an analysis of 84 cases.
  • Nasal-type extranodal natural killer (NK)/T-cell lymphoma is an uncommon malignancy.
  • By using a tissue microarray, we characterized 84 cases of extranodal NK/T-cell lymphoma with regard to expression of 18 immunohistochemical markers and the presence of Epstein-Barr virus (EBV) RNA.
  • Hierarchical cluster analysis separated primary cutaneous cases from cases manifesting in other sites based on lower expression of the cell adhesion molecule CD54.
  • [MeSH-major] Epstein-Barr Virus Infections / pathology. Immunohistochemistry / methods. Lymphoma, T-Cell, Peripheral / pathology. Nose Neoplasms / pathology
  • [MeSH-minor] Antigens, CD45 / biosynthesis. Herpesvirus 4, Human. Humans. In Situ Hybridization. Killer Cells, Natural / pathology. Microarray Analysis. RNA, Viral / analysis. T-Lymphocytes, Cytotoxic / pathology

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  • (PMID = 18701406.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA34233
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Viral; EC 3.1.3.48 / Antigens, CD45; EC 3.1.3.48 / PTPRC protein, human
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88. Hasserjian RP, Harris NL: NK-cell lymphomas and leukemias: a spectrum of tumors with variable manifestations and immunophenotype. Am J Clin Pathol; 2007 Jun;127(6):860-8
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  • [Title] NK-cell lymphomas and leukemias: a spectrum of tumors with variable manifestations and immunophenotype.
  • Natural killer (NK) cells are lymphocytes that have some phenotypic and functional similarities to cytotoxic T cells but do not express the T-cell receptor complex.
  • NK-cell malignancies may be localized or disseminated at initial examination, and most behave aggressively.
  • The variable presentation of NK-cell lymphomas and leukemias suggests that they represent a spectrum of disease, with Epstein-Barr virus (EBV) implicated in the pathogenesis of most cases.
  • Using cases presented in Session 10 of the 2005 Society for Hematopathology/European Association for Haematopathology Workshop on T-cell and NK-cell malignancies, we discuss outstanding issues in the classification and diagnosis of NK-cell malignancies.
  • These difficulties are related to unusual sites of manifestation, atypical immunophenotypic features, and EBV+ T-cell tumors that resemble classical extranodal NK/T-cell lymphoma, nasal-type (EN-NK/T-NT).
  • [MeSH-major] Killer Cells, Natural / pathology. Leukemia / pathology. Lymphoma, Non-Hodgkin / pathology. T-Lymphocytes / pathology

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  • (PMID = 17509983.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Congresses
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Viral
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89. Zhao S, Liu WP, Zhang WY, Li GD: [Extranodal nasal type NK/T-cell lymphoma: the expression of Epstein-Barr virus latent membrane protein 1 and its significance of prognosis]. Sichuan Da Xue Xue Bao Yi Xue Ban; 2005 May;36(3):338-40
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  • [Title] [Extranodal nasal type NK/T-cell lymphoma: the expression of Epstein-Barr virus latent membrane protein 1 and its significance of prognosis].
  • To investigate the expression and prognostic significance of Epstein-Barr virus latent membrane protein 1 in extranodal nasal type NK/T-cell lymphoma in the Chengdu area.
  • METHODS: The expression of latent membrane protein-1 (LMP1) was detected by immunohistochemistry (IHC) and DNA-PCR in 67 cases of extranodal nasal type NK/T-cell lymphoma, and the differences in survival rate between positive and negative expression groups of LMP1-protien and LMP1-DNA were analyzed respectively.
  • CONCLUSION: LMP1 was shown to be closely associated with extranodal nasal type NK/T-cell lymphoma in Chengdu.
  • No relationship was found between the prognosis and the LMP1 expression in extranodal nasal type NK/T-cell lymphoma.
  • [MeSH-major] Epstein-Barr Virus Infections / virology. Lymphoma, T-Cell / virology. Nose Neoplasms / virology. Viral Matrix Proteins / biosynthesis

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  • (PMID = 15931862.001).
  • [ISSN] 1672-173X
  • [Journal-full-title] Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
  • [ISO-abbreviation] Sichuan Da Xue Xue Bao Yi Xue Ban
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / EBV-associated membrane antigen, Epstein-Barr virus; 0 / Viral Matrix Proteins; 0 / Viral Proteins
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90. Wu X, Li P, Zhao J, Yang X, Wang F, Yang YQ, Fang F, Xu Y, Zhang H, Wang WY, Yi C: A clinical study of 115 patients with extranodal natural killer/T-cell lymphoma, nasal type. Clin Oncol (R Coll Radiol); 2008 Oct;20(8):619-25
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  • [Title] A clinical study of 115 patients with extranodal natural killer/T-cell lymphoma, nasal type.
  • AIMS: To investigate the clinicopathological features, treatment outcomes, and prognostic factors in patients with extranodal natural killer (NK)/T-cell lymphoma, nasal type.
  • MATERIALS AND METHODS: We retrospectively reviewed the medical records of 115 patients diagnosed with extranodal NK/T-cell lymphoma, nasal type who were admitted to our hospital between January 1991 and June 2006.
  • CONCLUSIONS: The prognosis of extranodal NK/T-cell lymphoma, nasal type is poor and significantly influenced by B symptoms, gender, IPI score, clinical staging and the method of treatment.
  • [MeSH-major] Lymphoma, Extranodal NK-T-Cell / therapy. Nose Neoplasms / therapy

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  • (PMID = 18790372.001).
  • [ISSN] 0936-6555
  • [Journal-full-title] Clinical oncology (Royal College of Radiologists (Great Britain))
  • [ISO-abbreviation] Clin Oncol (R Coll Radiol)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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91. Berk V, Yildiz R, Akdemir UO, Akyurek N, Karabacak NI, Coskun U, Benekli M: Disseminated extranodal NK/T-cell lymphoma, nasal type, with multiple subcutaneous nodules: utility of 18F-FDG PET in staging. Clin Nucl Med; 2008 May;33(5):365-6
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  • [Title] Disseminated extranodal NK/T-cell lymphoma, nasal type, with multiple subcutaneous nodules: utility of 18F-FDG PET in staging.
  • A 49-year-old man presented with a left nasal cavity mass, biopsy of which revealed extranodal NK/T cell lymphoma.
  • A PET-CT scan showed increased F-18 FDG uptake in the nasal mass, anterior mediastinal lymph nodes, and multiple subcutaneous nodular deposits in the chest wall, gluteal region, and right femoral areas.
  • There is limited literature data on the use of the PET scan in the diagnosis and staging of extranodal nasal NK/T-cell lymphomas.
  • [MeSH-major] Fluorodeoxyglucose F18. Lymphoma, Extranodal NK-T-Cell / radionuclide imaging. Nose Neoplasms / radionuclide imaging. Positron-Emission Tomography / methods. Skin Neoplasms / radionuclide imaging

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  • (PMID = 18431160.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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92. Yu JH, Choi KD, Koh YW, Choi WJ, Song HJ, Lee GH, Jung HY, Kim JH: [A case of CD56+ extranodal NK/T-cell lymphoma, nasal type, presenting as a duodenal ulcer bleeding]. Korean J Gastroenterol; 2009 Sep;54(3):174-9
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  • [Title] [A case of CD56+ extranodal NK/T-cell lymphoma, nasal type, presenting as a duodenal ulcer bleeding].
  • Extranodal NK/T-cell lymphoma is a recently recognized distinct entity within the World Health Organization classification of lymphoid tumors.
  • It most commonly occurs in the nasal or paranasal areas and less frequently in the skin, the soft tissue, and the gastrointestinal tract.
  • Among these, extranodal NK/T-cell lymphoma of the gastrointestinal tract has shown an aggressive clinical course.
  • We report a case of CD56+ extranodal NK/T-cell lymphoma presenting as a duodenal ulcer bleeding.
  • Pathologic examination revealed the diffuse infiltration of atypical lymphocytes with an angiocentric growth pattern, which was positive for CD3, CD56, and granzyme.
  • [MeSH-major] Antigens, CD56 / metabolism. Duodenal Ulcer / diagnosis. Lymphoma, Extranodal NK-T-Cell / diagnosis. Peptic Ulcer Hemorrhage / diagnosis

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  • (PMID = 19844154.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Antigens, CD3; 0 / Antigens, CD56
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93. Lee SR, Park EK, Won NH, Kim BS: Esophageal involvement by extranodal natural killer T cell lymphoma, nasal type, mimicking Ebstein Barr viral esophagitis in a tonsillar lymphoma patient undergoing chemoradiation therapy. Asia Pac J Clin Oncol; 2010 Sep;6(3):149-54
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  • [Title] Esophageal involvement by extranodal natural killer T cell lymphoma, nasal type, mimicking Ebstein Barr viral esophagitis in a tonsillar lymphoma patient undergoing chemoradiation therapy.
  • Esophageal involvement by extranodal natural killer (NK)/T cell lymphoma, nasal type, is rare.
  • It is important to note, however, that benign conditions may mask esophageal involvement by lymphoma.
  • Until now, there has been no report documenting esophageal involvement by lymphoma mimicking viral esophagitis in an extranodal NK/T cell lymphoma patient undergoing active treatment.
  • Here, we report a case of esophageal involvement by extranodal NK/T cell lymphoma, nasal type, initially misdiagnosed as Ebstein Barr virus esophagitis.
  • Lymphoma invasion of the esophagus should be considered if esophageal symptoms do not respond to usual medical esophagitis therapy in an extranodal NK/T cell lymphoma, nasal type, patient undergoing chemoradiation.
  • [MeSH-major] Epstein-Barr Virus Infections / pathology. Esophageal Neoplasms / pathology. Esophagitis / pathology. Lymphoma, Extranodal NK-T-Cell / pathology
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Combined Modality Therapy. Diagnosis, Differential. Humans. Male. Middle Aged. Radiotherapy. Tonsillar Neoplasms / pathology. Tonsillar Neoplasms / therapy

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  • (PMID = 20887494.001).
  • [ISSN] 1743-7563
  • [Journal-full-title] Asia-Pacific journal of clinical oncology
  • [ISO-abbreviation] Asia Pac J Clin Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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94. Min HS, Hyun CL, Paik JH, Jeon YK, Choi G, Park SH, Seo JW, Kim CW: An autopsy case of aggressive CD30+ extra-nodal NK/T-cell lymphoma initially manifested with granulomatous myositis. Leuk Lymphoma; 2006 Feb;47(2):347-52
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  • [Title] An autopsy case of aggressive CD30+ extra-nodal NK/T-cell lymphoma initially manifested with granulomatous myositis.
  • This study reports an autopsy case of a 53 year-old male with rapidly progressive extra-nodal NK/T-cell lymphoma accompanied with unusual clinical and pathologic features.
  • He was initially presented with localized swelling and tenderness in the right lower extremity and the biopsy from the calf muscle was interpreted as granulomatous myositis masquerizing lymphoma.
  • The biopsy from erythematous skin lesion of trunk showed infiltration of medium sized atypical lymphoid cells with relatively plump cytoplasm and immunophenotype of CD30+, CD56+/- and surface CD3-, which lead to the diagnosis of CD30+ anaplastic large cell lymphoma.
  • About 2 months later, nasal obstruction was developed and the nasal biopsy was done.
  • After confirmation of EBV infection, he was finally diagnosed as extra-nodal NK/T-cell lymphoma with peculiar immunophenotype of CD3 dim+ and CD30+.
  • At autopsy, disseminated angiocentric lymphoma was found all over the internal organs including the brain.
  • This case emphasizes that extra-nodal NK/T-cell lymphoma should be considered as a cause of granulomatous myositis and can express CD30 positivity and CD3 weak positivity, which are unusual but rarely predominant feature of NK/T-cell lymphoma.
  • [MeSH-major] Antigens, CD30 / immunology. Granuloma / pathology. Killer Cells, Natural / pathology. Lymphoma, T-Cell / pathology. Myositis / pathology

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  • (PMID = 16321870.001).
  • [ISSN] 1042-8194
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD3; 0 / Antigens, CD30; 0 / CD3 antigen, zeta chain
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95. Chia HY, Tey HL, Tan KB, Chong WS: Nasal-type extranodal natural killer/T-cell lymphoma presenting with extensive leg ulcers. Clin Exp Dermatol; 2009 Dec;34(8):e693-5
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  • [Title] Nasal-type extranodal natural killer/T-cell lymphoma presenting with extensive leg ulcers.
  • Primary cutaneous T-cell lymphomas are rare and can be difficult to classify precisely.
  • We present a case of extranodal natural killer (NK)/T-cell lymphoma in a previously healthy, immunocompetent man who presented with extensive necrotic leg ulcers and disseminated skin nodules.
  • Immunohistochemical studies revealed that the tumour cells were positive for CD3, CD30, granzyme B and T-cell intracellular antigen-1, and negative for CD5 and CD56, with positive staining for Epstein-Barr virus (EBV) RNA on in situ hybridization.
  • A diagnosis of extranodal NK/T-cell lymphoma was made, based on the presence of cytotoxic granules and positive EBV RNA staining.
  • [MeSH-major] Leg Ulcer / pathology. Lymphoma, Extranodal NK-T-Cell / pathology. Lymphoma, T-Cell, Cutaneous / pathology. Skin Neoplasms / pathology

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  • (PMID = 20055838.001).
  • [ISSN] 1365-2230
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD30; 0 / Antigens, CD56; 0 / Biomarkers, Tumor
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96. Yokoyama H, Yamada MF, Ishizawa K, Yamamoto J, Tomiya Y, Harigae H, Kameoka J, Ichinohasama R, Sasaki T: Successful treatment of advanced extranodal NK/T cell lymphoma with unrelated cord blood transplantation. Tohoku J Exp Med; 2007 Apr;211(4):395-9
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  • [Title] Successful treatment of advanced extranodal NK/T cell lymphoma with unrelated cord blood transplantation.
  • Nasal natural killer (NK)/T cell lymphoma is a rare entity of non-Hodgkin's lymphoma which mostly occurs in East Asian countries.
  • Thus the prognosis of advanced NK/T cell lymphoma is generally poor, however, the promising results of allogeneic hematopoietic stem cell transplantation for advanced NK/T cell lymphoma have been recently reported.
  • In most of these cases, stem cell sources were human leukocyte antigen (HLA) matched donors and alternative sources were seldom used.
  • We report here a case of a 36-year-old woman who was diagnosed as having an extranodal NK/T cell lymphoma, nasal type.
  • Cord blood thus could be an appropriate stem cell source for patients with advanced NK/T lymphoma who have no HLA matched donors.
  • [MeSH-major] Cord Blood Stem Cell Transplantation. Lymphoma, T-Cell / therapy
  • [MeSH-minor] Adult. Female. Histocompatibility Testing. Humans. Killer Cells, Natural / pathology. Nose Neoplasms / pathology. Nose Neoplasms / therapy. Tissue Donors

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  • (PMID = 17409680.001).
  • [ISSN] 0040-8727
  • [Journal-full-title] The Tohoku journal of experimental medicine
  • [ISO-abbreviation] Tohoku J. Exp. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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97. Katsaounis P, Alexopoulou A, Dourakis SP, Smyrnidis A, Marinos L, Filiotou A, Archimandritis AJ: An extranodal NK/T cell lymphoma, nasal type, with specific immunophenotypic and genotypic features. Int J Hematol; 2008 Sep;88(2):202-5
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  • [Title] An extranodal NK/T cell lymphoma, nasal type, with specific immunophenotypic and genotypic features.
  • Extranodal NK/T cell lymphoma, 'nasal type,' is a rare clinicopathological entity in Europe.
  • The main clinical features are nasal congestion, sore throat, dysphagia and epistaxis, due to a destructive mass involving the midline facial tissues.
  • Pathologically, lymphoma cells exhibit angioinvasion, angiodestruction and coagulative necrosis.
  • We report the case of a patient who presented with fever, dyspnea, nasal congestion, headache, distention of right nasal turbinates and exophytic lower leg ulcerating lesions.
  • A biopsy was performed in the skin lesion and showed an angioinvasive NK/T cell lymphoma CD56 negative with clonal rearrangement of the T-cell-receptor gamma gene.
  • Up to our knowledge, this is a rare immunophenotype for NK/T-cell, 'nasal type,' lymphomas.
  • However, the lymphoma may be classified as extranodal NK/T cell lymphoma, 'nasal type,' due to typical clinical presentation, radiologic findings and pathological characteristics of polymorphism, angioinvasion, angiodestruction and coagulative necrosis.
  • [MeSH-major] Killer Cells, Natural / pathology. Lymphoma, T-Cell / genetics. Lymphoma, T-Cell / pathology. Nose Neoplasms / genetics. Nose Neoplasms / pathology

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  • (PMID = 18654739.001).
  • [ISSN] 0925-5710
  • [Journal-full-title] International journal of hematology
  • [ISO-abbreviation] Int. J. Hematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antigens, CD56
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98. Ren X, Jia Q, Xiang G, Zhao Z, Xu K, Du W: [Clinical study of 34 patients with extranodal NK/T cell lymphoma-nasal type]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2007 Apr;21(8):361-2
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  • [Title] [Clinical study of 34 patients with extranodal NK/T cell lymphoma-nasal type].
  • OBJECTIVE: To explore the clinical feature, the reason of misdiagnosis and mistreatment, influential factor of prognosis in patients with extranodal NK/T cell lymphoma-nasal type.
  • METHOD: A retrospective study was made on the clinical data of 34 patients with extranodal NK/T cell lymphoma-nasal type.
  • Among them, 10 cases were staged I(E) intra-cavity, 15 cases were I(E) ex-cavity, 6 cases were II(E) and 3 cases were IV(E).
  • Among them, 29 cases were in nasal cavity, 5 cases were outside nasal cavity; 14 cases were treated with single chemotherapy or radiation therapy, 20 cases were treated with radiation therapy add chemotherapy.
  • The 5-year survival rate of the I(E) intra-cavity group were 60.0% (6/10), and those of I(E) ex-cavity group were 26.7% (4/15), and those of II(E) group and IV(E) group were 16.7% (1/6), 0% (0/3), respectively There was significant difference between 3 groups by statistical analysis (P < 0.01).
  • The 5-year survival rate of I(E) ex-cavity group treated with single therapy were 0% (0/6), and those of I(E)-cavity group treated with combined therapy were 50% (1/2).
  • CONCLUSION: The early clinical manifestation of extranodal NK/T tell lymphoma-nasal type is atypical and which is hard to diagnose and treat.
  • Diagnosis depends on pathologic biopsy and immunohistochemistry, there are many factors that influence the prognosis of this disease, in which the clinical stage is a major factor.
  • [MeSH-major] Lymphoma, Extranodal NK-T-Cell. Nose Neoplasms

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  • (PMID = 17608157.001).
  • [ISSN] 1001-1781
  • [Journal-full-title] Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
  • [ISO-abbreviation] Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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99. Watanabe T, Kinoshita T, Itoh K, Yoshimura K, Ogura M, Kagami Y, Yamaguchi M, Kurosawa M, Tsukasaki K, Kasai M, Tobinai K, Kaba H, Mukai K, Nakamura S, Ohshima K, Hotta T, Shimoyama M: Pretreatment total serum protein is a significant prognostic factor for the outcome of patients with peripheral T/natural killer-cell lymphomas. Leuk Lymphoma; 2010 May;51(5):813-21
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  • [Title] Pretreatment total serum protein is a significant prognostic factor for the outcome of patients with peripheral T/natural killer-cell lymphomas.
  • Peripheral T- and NK-cell lymphomas (PT/NKCLs) are relatively rare, and few studies have validated the International Prognostic Index (IPI) for PT/NKCLs in prospective clinical trials.
  • In a univariate analysis, low total serum protein (TP) and albumin levels, gastrointestinal tract involvement, and histologic subtype (extranodal NK/T-cell lymphoma, nasal type, and peripheral T-cell lymphoma, unspecified) were significantly associated with reduced survival.
  • [MeSH-major] Biomarkers, Tumor / blood. Blood Proteins / metabolism. Lymphoma, Extranodal NK-T-Cell / blood. Lymphoma, Large B-Cell, Diffuse / blood. Lymphoma, T-Cell, Peripheral / blood
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Female. Humans. Killer Cells, Natural / drug effects. Killer Cells, Natural / pathology. Male. Middle Aged. Prospective Studies. Retrospective Studies. Survival Rate. Treatment Outcome

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  • (PMID = 20367565.001).
  • [ISSN] 1029-2403
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Blood Proteins
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100. Nishihara H, Tateishi U, Itoh T, Nagashima K, Tanaka S: Immunohistochemical and gene rearrangement studies of central nervous system lymphomatoid granulomatosis. Neuropathology; 2007 Oct;27(5):413-8
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  • Lymphomatoid granulomatosis (LYG) is a rare multisystem disorder with characteristic angiocentric lymphoproliferative features, most frequently involving the lung, skin, and rarely the CNS.
  • Most systemic LYGs have been shown to be EBV-associated, T-cell rich, B-cell proliferative disorders.
  • Here, we present four cases of LYG arising from the CNS and have analyzed them by immunohistochemistry to assess the phenotype of the infiltrate, and by PCR-SSCP (single-strand conformation polymorphism) analysis for immunoglobulin heavy chain (IgH) and T-cell receptor (TcR) gamma gene rearrangements.
  • Three cases revealed perivascular infiltration of T-cell dominant lymphoid cells, two cases showed monoclonal TcRgamma gene rearrangement, while the remaining case had a B-cell immunophenotype and monoclonal IgH gene rearrangement with EBV genome expression.
  • This is the first report of a gene rearrangement study on CNS-LYG.
  • We confirm that some cases of CNS-LYG are derived from T-cell monoclonal lymphoproliferative disease, although this disease should be classified as a borderline malignancy and should be separated from overt malignant lymphoma of CNS.
  • [MeSH-major] Central Nervous System Diseases / pathology. Gene Rearrangement. Genes, T-Cell Receptor gamma. Immunoglobulin Heavy Chains / genetics. Lymphomatoid Granulomatosis / pathology
  • [MeSH-minor] Antigens, CD / analysis. Humans. Immunohistochemistry. In Situ Hybridization. Phenotype. Polymerase Chain Reaction. Polymorphism, Single-Stranded Conformational. Receptors, Antigen, T-Cell, gamma-delta / genetics

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  • (PMID = 18018473.001).
  • [ISSN] 0919-6544
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Immunoglobulin Heavy Chains; 0 / Receptors, Antigen, T-Cell, gamma-delta
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