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1. Peral-Cagigal B, Galdeano-Arenas M, Crespo-Pinilla JI, García-Cantera JM, Sánchez-Cuéllar LA, Verrier-Hernández A: Centrofacial angiocentric lymphoma. Med Oral Patol Oral Cir Bucal; 2005 Jan-Feb;10(1):92-4; 90-2
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  • [Title] Centrofacial angiocentric lymphoma.
  • The centrofacial angiocentric lymphoma is a rare lymphoid neoplasm, with an often-difficult diagnosis due to the non-specific clinical picture.
  • On many occasions it is necessary to perform various biopsies to reach the correct diagnosis.
  • This lymphoma is an aggressive Non-Hodgkin's (NHL) type, which is normally found in the upper respiratory tract (predominantly in the nasal cavity), and has an ominous prognosis, as the average survival rate is between 12 and 18 months (1).
  • This is the case study of a female Ecuadorian patient who was referred to our department with a hemifacial edema, chocolate- like rhinorrhea and nasal respiratory obstruction, which had been treated with antibiotics and anti-inflammatories for a month without success.
  • After performing a number of diagnostic tests, it was found histologically that the patient had an extranodal T-cell lymphoma of the nasal type (also known as T-cell angiocentric lymphoma).
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Lymphoma, T-Cell / diagnosis

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  • (PMID = 15627913.001).
  • [ISSN] 1698-4447
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng; spa
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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2. Chow C, Liu AY, Chan WS, Lei KI, Chan WY, Lo AW: AKT plays a role in the survival of the tumor cells of extranodal NK/T-cell lymphoma, nasal type. Haematologica; 2005 Feb;90(2):274-5
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  • [Title] AKT plays a role in the survival of the tumor cells of extranodal NK/T-cell lymphoma, nasal type.
  • Phosphorylated AKT has been detected in extranodal NK/T-cell lymphoma, nasal type (ENTL).
  • Either interleukin-2 (IL-2) or interleukin-15 (IL-15) could prevent AKT dephosphorylation and apoptosis in the NK-92 cell line model.
  • [MeSH-major] Killer Cells, Natural / cytology. Lymphoma, T-Cell / immunology. Nose Neoplasms / immunology. Proto-Oncogene Proteins c-akt / physiology
  • [MeSH-minor] Cell Line, Tumor. Cell Survival. Humans. Immunohistochemistry. Immunophenotyping. Interleukin-15 / blood. Interleukin-15 / metabolism. Interleukin-2 / metabolism. Lymphoma / pathology. Phosphorylation

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  • (PMID = 15710591.001).
  • [ISSN] 1592-8721
  • [Journal-full-title] Haematologica
  • [ISO-abbreviation] Haematologica
  • [Language] eng
  • [Publication-type] Letter; Research Support, Non-U.S. Gov't
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Interleukin-15; 0 / Interleukin-2; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt
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3. Yu JH, Choi KD, Koh YW, Choi WJ, Song HJ, Lee GH, Jung HY, Kim JH: [A case of CD56+ extranodal NK/T-cell lymphoma, nasal type, presenting as a duodenal ulcer bleeding]. Korean J Gastroenterol; 2009 Sep;54(3):174-9

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  • [Title] [A case of CD56+ extranodal NK/T-cell lymphoma, nasal type, presenting as a duodenal ulcer bleeding].
  • Extranodal NK/T-cell lymphoma is a recently recognized distinct entity within the World Health Organization classification of lymphoid tumors.
  • It most commonly occurs in the nasal or paranasal areas and less frequently in the skin, the soft tissue, and the gastrointestinal tract.
  • Among these, extranodal NK/T-cell lymphoma of the gastrointestinal tract has shown an aggressive clinical course.
  • We report a case of CD56+ extranodal NK/T-cell lymphoma presenting as a duodenal ulcer bleeding.
  • Pathologic examination revealed the diffuse infiltration of atypical lymphocytes with an angiocentric growth pattern, which was positive for CD3, CD56, and granzyme.
  • [MeSH-major] Antigens, CD56 / metabolism. Duodenal Ulcer / diagnosis. Lymphoma, Extranodal NK-T-Cell / diagnosis. Peptic Ulcer Hemorrhage / diagnosis

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  • (PMID = 19844154.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Antigens, CD3; 0 / Antigens, CD56
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4. Bene NI, Zeitouni NC, Cheney R: Unusual cutaneous manifestation of angiocentric T-cell lymphoma: a case report. Cutis; 2006 May;77(5):310-2
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  • [Title] Unusual cutaneous manifestation of angiocentric T-cell lymphoma: a case report.
  • Angiocentric T-cell lymphoma may clinically present with a broad variety of cutaneous manifestations, including papules, nodules, and ulcerated tumors, and may mimic cutaneous vasculitis and Wegener granulomatosis.
  • Histologic diagnosis of angiocentric T-cell lymphoma also may present a challenge because of variations in the degree of cellular infiltrate and cellular atypia.
  • The correct diagnosis is critical because of the importance of choosing the correct therapeutic modality-chemotherapy or x-ray radiation.
  • We report a case of angiocentric T-cell lymphoma with extensive necrotic facial ulcers that responded to treatment with fludarabine, cyclophosphamide, and prednisone.
  • [MeSH-major] Facial Neoplasms / pathology. Lymphoma, T-Cell, Cutaneous / pathology. Skin Neoplasms / pathology

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  • (PMID = 16776287.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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5. Yoshioka T, Harada M, Umekita Y, Taguchi S, Higashi M, Nakamura D, Suzuki S, Tanimoto A: Necrotizing sialometaplasia of the parotid gland associated with angiocentric T-cell lymphoma: a case report and review of the literature. Pathol Int; 2010 Apr;60(4):326-9
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  • [Title] Necrotizing sialometaplasia of the parotid gland associated with angiocentric T-cell lymphoma: a case report and review of the literature.
  • A very rare case of necrotizing sialometaplasia of the parotid gland associated with angiocentric T-cell lymphoma was described.
  • Angiocentric pattern or vascular invasion by the lymphoid cells was observed and the involved parotid gland exhibited squamous metaplasia of the ducts and acini; necrotizing sialometaplasia.
  • Immunohistochemical analysis revealed a cytotoxic T-cell phenotype of the lymphoid cells (CD3+, CD4-, CD5+, CD8+, CD56-, Granzyme B+, TIA-1+, Perforin-) but in situ hybridization showed no relation to Epstein-Barr virus.
  • Although necrotizing sialometaplasia is relatively rare in the parotid gland, angiocentric T-cell lymphoma should be considered for a causative condition of necrotizing sialometaplasia.
  • [MeSH-major] Lymphoma, T-Cell / pathology. Neovascularization, Pathologic / pathology. Parotid Gland / pathology. Sialometaplasia, Necrotizing / pathology

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  • (PMID = 20403036.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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6. Wang ZY, Li YX, Wang WH, Jin J, Wang H, Song YW, Liu QF, Wang SL, Liu YP, Qi SN, Fang H, Liu XF, Yu ZH: Primary radiotherapy showed favorable outcome in treating extranodal nasal-type NK/T-cell lymphoma in children and adolescents. Blood; 2009 Nov 26;114(23):4771-6
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  • [Title] Primary radiotherapy showed favorable outcome in treating extranodal nasal-type NK/T-cell lymphoma in children and adolescents.
  • Extranodal nasal-type natural killer (NK)/T-cell lymphoma is rarely observed in children and adolescents.
  • Children and adolescents with extranodal nasal-type NK/T-cell lymphoma usually presented with early-stage disease, high frequency of B symptoms, good performance, low-risk age-adjusted international prognostic index, and chemoresistance.
  • Children and adolescents with early-stage extranodal nasal-type NK/T-cell lymphoma treated with primary radiotherapy had a favorable prognosis.
  • [MeSH-major] Lymphoma, Extranodal NK-T-Cell / radiotherapy. Nose Neoplasms / radiotherapy. Pharyngeal Neoplasms / radiotherapy

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  • (PMID = 19812381.001).
  • [ISSN] 1528-0020
  • [Journal-full-title] Blood
  • [ISO-abbreviation] Blood
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CHOP protocol
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7. Kim TM, Heo DS: Extranodal NK / T-cell lymphoma, nasal type: new staging system and treatment strategies. Cancer Sci; 2009 Dec;100(12):2242-8
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  • [Title] Extranodal NK / T-cell lymphoma, nasal type: new staging system and treatment strategies.
  • Extranodal NK/T-cell lymphoma (NTCL) is characterized by clinical heterogeneity based on clinical prognostic factors and survival outcome.
  • Ann Arbor staging for lymphomas and the International Prognostic Index (IPI) have been used to predict prognosis for UAT-NTCL; however, local tumor invasiveness (bony invasion or perforation or invasion of the overlying skin) is the most significant factor for poor outcomes in localized UAT-NTCL.
  • [MeSH-major] Lymphoma, Extranodal NK-T-Cell / pathology. Nose Neoplasms / pathology

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  • (PMID = 19758393.001).
  • [ISSN] 1349-7006
  • [Journal-full-title] Cancer science
  • [ISO-abbreviation] Cancer Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Number-of-references] 65
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8. Wang B, Li XQ, Ma X, Hong X, Lu H, Guo Y: Immunohistochemical expression and clinical significance of P-glycoprotein in previously untreated extranodal NK/T-cell lymphoma, nasal type. Am J Hematol; 2008 Oct;83(10):795-9
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  • [Title] Immunohistochemical expression and clinical significance of P-glycoprotein in previously untreated extranodal NK/T-cell lymphoma, nasal type.
  • Overexpression of P-glycoprotein (P-gp) has been identified by a variety of methods in NK cells and NK malignancies.
  • The aim of this study was to determine the clinical significance of P-gp in previously untreated extranodal NK/T-cell lymphoma, nasal type.
  • Our results suggest that P-gp expression is related with poor treatment outcomes of extranodal NK/T-cell lymphoma, nasal type.
  • [MeSH-major] Killer Cells, Natural / metabolism. Lymphoma, T-Cell / pathology. Nose. Nose Neoplasms / pathology. P-Glycoprotein / metabolism

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  • [Copyright] Copyright 2008 Wiley-Liss, Inc.
  • (PMID = 18756548.001).
  • [ISSN] 1096-8652
  • [Journal-full-title] American journal of hematology
  • [ISO-abbreviation] Am. J. Hematol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / P-Glycoprotein; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CHOP protocol
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9. Takahashi E, Asano N, Li C, Tanaka T, Shimada K, Shimada S, Yoshino T, Kojima M, Hara K, Eimoto T, Nakamura S: Nodal T/NK-cell lymphoma of nasal type: a clinicopathological study of six cases. Histopathology; 2008 Apr;52(5):585-96
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  • [Title] Nodal T/NK-cell lymphoma of nasal type: a clinicopathological study of six cases.
  • AIMS: To investigate the clinicopathological features of six unusual cases of nodal CD56+ and Epstein-Barr virus (EBV)+ T/natural killer (NK)-cell lymphoma, a putative nodal counterpart of nasal NK/T-cell lymphoma (nodal T/NK-cell lymphoma of nasal type) in comparison with nasal NK/T-cell lymphoma with secondary lymph node involvement (n = 24) and peripheral T-cell lymphoma (PTCL) of cytotoxic molecule (CTM)+ and EBV+ type (n = 21).
  • METHODS AND RESULTS: All cases of nodal T/NK-cell lymphoma of nasal type exhibited diffuse infiltration of pleomorphic medium-sized to large tumour cells, reminiscent of those in CTM+ EBV+ PTCL.
  • The tumour cells had a typical phenotype of nasal NK/T-cell lymphoma: CD2+, CD3epsilon+, CD4-, CD5-, CD56+, T-cell intracellular antigen-1+, granzyme B+, perforin+ and EBV+.
  • However, four of six cases demonstrated clonal T-cell receptor gamma-gene rearrangement on polymerase chain reaction analysis, unlike nasal NK/T-cell lymphoma.
  • CONCLUSIONS: Nodal T/NK-cell lymphoma may occupy the grey zone between extranodal nasal-type NK/T-cell lymphoma and nodal CTM+ PTCL in a spectrum of NK to T-cell lymphomas that are EBV+.
  • The close relationship between NK/T-cell lymphomas and cytotoxic T-cell lymphomas was also substantiated.
  • [MeSH-major] Epstein-Barr Virus Infections / pathology. Killer Cells, Natural / pathology. Lymph Nodes / pathology. Lymphoma, T-Cell, Peripheral / pathology. Nose Neoplasms / pathology. T-Lymphocytes, Cytotoxic / pathology

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  • (PMID = 18370955.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / RNA, Viral
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10. Dominguez-Malagon H, Mosqueda-Taylor A, Cano-Valdez AM: Necrotizing sialometaplasia of the palate associated with angiocentric T-cell lymphoma. Ann Diagn Pathol; 2009 Feb;13(1):60-4
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  • [Title] Necrotizing sialometaplasia of the palate associated with angiocentric T-cell lymphoma.
  • In this article we present 2 cases of necrotizing sialometaplasia (NS) associated with angiocentric lymphoma of the midline.
  • Immunohistochemical analysis confirmed a T-cell origin, and in situ hybridization in one case revealed its relationship to Epstein-Barr virus.
  • To our knowledge, the association between angiocentric lymphoma and NS has been previously reported in only one instance, and we suggest that this particular type of lymphoma should be added to the list of related conditions for NS.
  • [MeSH-major] Epstein-Barr Virus Infections / complications. Lymphoma, T-Cell / complications. Palatal Neoplasms / complications. Paranasal Sinus Neoplasms / complications. Sialometaplasia, Necrotizing / diagnosis. Sialometaplasia, Necrotizing / etiology

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  • (PMID = 19118785.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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11. Aydin GB, Akyuz C, Talim B, Evans SE, Sahin S, Sari N, Tabanlioglu D, Ozen S, Cağlar M, Büyükpamukçu M: Extranodal type T/NK-cell lymphoma with an atypical clinical presentation. Pediatr Hematol Oncol; 2007 Jun;24(4):291-9

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  • [Title] Extranodal type T/NK-cell lymphoma with an atypical clinical presentation.
  • Peripheral-type natural killer (NK)- or T-cell lymphomas are rare disorders characterized with clonal proliferation of mature lymphocytes.
  • They have been linked to chronic and active Epstein-Barr virus infection (CAEBV), which itself is not defined as a malignant hematological disorder.
  • The authors present a patient with T/NK-cell lymphoma involving skin, kidneys, spleen, pancreas, and meninges.
  • She was remarkable for having the mosaic feature of more than one type of extranodal T/NK-cell lymphoma.
  • [MeSH-major] Killer Cells, Natural / pathology. Lymphoma, T-Cell / pathology

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  • (PMID = 17613872.001).
  • [ISSN] 1521-0669
  • [Journal-full-title] Pediatric hematology and oncology
  • [ISO-abbreviation] Pediatr Hematol Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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12. Khosravi Shahi P, Díaz Muñoz de la Espada VM: [Extranodal T/NK-cell lymphoma, nasal type: a case report and review of the literature]. An Med Interna; 2005 Dec;22(12):597-600
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  • [Title] [Extranodal T/NK-cell lymphoma, nasal type: a case report and review of the literature].
  • [Transliterated title] Linfoma T/NK extraganglionar tipo nasal: caso clínico y revisión de la literatura.
  • Extranodal T/NK-cell lymphoma, nasal type: a case report and review of the literature.
  • Extranodal NK/T-cell lymphoma, nasal type, is an extranodal lymphoma, usually with an NK-cell phenotype and EBV positive, with a broad morphologic spectrum, frequent necrosis and angioinvasion, and most commonly presenting in the midfacial region, but also in other extranodal sites.
  • We present the case of a 42-years old-man with a intranasal mass, left cervical adenopathies and indolent thrombocytosis.
  • The biopsy of the nasal mass showed a diffuse infiltrate of medium-sized lymphoid cells, with slightly irregular nuclei and moderate polymorphous.
  • The diagnosis of the case was Extranodal T/NK-cell lymphoma, nasal type.
  • With the diagnosis of localized extranodal T/NK-cell lymphoma and reactive thrombocytosis, the patient was treated with chemotherapy and sequential radiotherapy, followed by bone marrow transplantation.
  • [MeSH-major] Killer Cells, Natural. Lymphoma, T-Cell / pathology. Nose Neoplasms / pathology

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  • (PMID = 16454602.001).
  • [ISSN] 0212-7199
  • [Journal-full-title] Anales de medicina interna (Madrid, Spain : 1984)
  • [ISO-abbreviation] An Med Interna
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 16
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13. Laetsch B, Hofbauer G, Kempf W, Burg G, Dummer R: Atypical poorly differentiated cutaneous T-cell lymphoma with an angiocentric growth pattern presenting histologically as vasculitis. Dermatology; 2005;210(4):341-5
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  • [Title] Atypical poorly differentiated cutaneous T-cell lymphoma with an angiocentric growth pattern presenting histologically as vasculitis.
  • We report the case of a 41-year-old patient with an aggressive cutaneous T-cell lymphoma (CTCL) initially presenting on histology as lymphocytic vasculitis.
  • On repeated histological examination and by molecular biology work-up, the diagnosis of an unclassifiable CTCL could eventually be established.
  • This atypical poorly differentiated lymphoma was of a CD4+ CD8- CD56- phenotype and followed an unfavourable course.
  • The patient died despite chemo- and immunotherapy 7 months after the first consideration of lymphoma as diagnosis.
  • [MeSH-major] Lymphoma, T-Cell, Cutaneous / pathology. Skin Neoplasms / pathology. Vasculitis / pathology
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biopsy, Needle. Diagnosis, Differential. Disease Progression. Fatal Outcome. Humans. Immunohistochemistry. Male. Risk Assessment

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  • [Copyright] 2005 S. Karger AG, Basel
  • (PMID = 15942225.001).
  • [ISSN] 1018-8665
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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14. Miles RR, Afify Z, Yaish H, Perkins SL: CD56-negative extranodal nasal type NK/T-cell lymphoma. Pediatr Blood Cancer; 2010 Jul 15;55(1):186-9
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  • [Title] CD56-negative extranodal nasal type NK/T-cell lymphoma.
  • Extranodal natural killer (NK)/T-cell lymphoma, nasal type, is a rare lymphoma that occurs predominantly in Asian adults.
  • In this report, we describe the clinical and pathologic features of an unusual aggressive lymphoid neoplasm in a child and review the literature on NK/T-cell lymphoma in children.
  • This case represents an extranodal NK/T-cell lymphoma, nasal type, with an unusual lack of CD56.
  • [MeSH-major] Lymphoma, Extranodal NK-T-Cell / drug therapy

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  • (PMID = 20486184.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD56
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15. Briese J, Noack F, Harland A, Horny HP: Primary extranodal NK/T cell lymphoma ("nasal type") of the endometrium: report of an unusual case diagnosed at autopsy. Gynecol Obstet Invest; 2006;61(3):164-6

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  • [Title] Primary extranodal NK/T cell lymphoma ("nasal type") of the endometrium: report of an unusual case diagnosed at autopsy.
  • Primary natural killer (NK)/T cell lymphoma of the female genital tract is extremely rare.
  • We here report the case of a "nasal type" NK/T cell lymphoma arising in the uterus.
  • The diagnosis was established only at autopsy.
  • [MeSH-major] Endometrial Neoplasms / pathology. Killer Cells, Natural / pathology. Lymphoma, T-Cell / pathology

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  • [Copyright] Copyright (c) 2006 S. Karger AG, Basel.
  • (PMID = 16424671.001).
  • [ISSN] 0378-7346
  • [Journal-full-title] Gynecologic and obstetric investigation
  • [ISO-abbreviation] Gynecol. Obstet. Invest.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Antigens, Differentiation, T-Lymphocyte; 0 / Biomarkers, Tumor
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16. Al-Hakeem DA, Fedele S, Carlos R, Porter S: Extranodal NK/T-cell lymphoma, nasal type. Oral Oncol; 2007 Jan;43(1):4-14

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  • [Title] Extranodal NK/T-cell lymphoma, nasal type.
  • Extranodal NK/T-cell lymphoma, nasal type (ENKTCL), previously known as lethal midline granuloma is a distinct clinico-pathological entity associated with Epstein-Barr virus that typically causes destruction of the midface, palatal and orbital walls.
  • ENKTCL neoplastic cells express some T-cell associated antigens, most commonly CD2 and cytoplasmic CD3epsilon and, in favour of an NK-cell origin, CD56.
  • [MeSH-major] Granuloma, Lethal Midline / pathology. Lymphoma, T-Cell / pathology

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  • (PMID = 17064952.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 142
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17. Katsaounis P, Alexopoulou A, Dourakis SP, Smyrnidis A, Marinos L, Filiotou A, Archimandritis AJ: An extranodal NK/T cell lymphoma, nasal type, with specific immunophenotypic and genotypic features. Int J Hematol; 2008 Sep;88(2):202-5
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  • [Title] An extranodal NK/T cell lymphoma, nasal type, with specific immunophenotypic and genotypic features.
  • Extranodal NK/T cell lymphoma, 'nasal type,' is a rare clinicopathological entity in Europe.
  • The main clinical features are nasal congestion, sore throat, dysphagia and epistaxis, due to a destructive mass involving the midline facial tissues.
  • Pathologically, lymphoma cells exhibit angioinvasion, angiodestruction and coagulative necrosis.
  • We report the case of a patient who presented with fever, dyspnea, nasal congestion, headache, distention of right nasal turbinates and exophytic lower leg ulcerating lesions.
  • A biopsy was performed in the skin lesion and showed an angioinvasive NK/T cell lymphoma CD56 negative with clonal rearrangement of the T-cell-receptor gamma gene.
  • Up to our knowledge, this is a rare immunophenotype for NK/T-cell, 'nasal type,' lymphomas.
  • However, the lymphoma may be classified as extranodal NK/T cell lymphoma, 'nasal type,' due to typical clinical presentation, radiologic findings and pathological characteristics of polymorphism, angioinvasion, angiodestruction and coagulative necrosis.
  • [MeSH-major] Killer Cells, Natural / pathology. Lymphoma, T-Cell / genetics. Lymphoma, T-Cell / pathology. Nose Neoplasms / genetics. Nose Neoplasms / pathology

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  • (PMID = 18654739.001).
  • [ISSN] 0925-5710
  • [Journal-full-title] International journal of hematology
  • [ISO-abbreviation] Int. J. Hematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD56
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18. Kishimoto K, Kitamura T, Hirayama Y, Tate G, Mitsuya T: Three cases of extranodal NK/T-cell lymphoma of the nasal type diagnosed by nasal brush cytology. Diagn Cytopathol; 2007 Feb;35(2):125-9
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  • [Title] Three cases of extranodal NK/T-cell lymphoma of the nasal type diagnosed by nasal brush cytology.
  • Extranodal natural killer (NK)/T-cell lymphoma of the nasal type is a rare type of malignant lymphoma that is most common in Asian countries.
  • Here we describe cytomorphologic, immunocytochemical, and molecular cytochemical features of three cases of NK/T-cell lymphoma of the nasal type diagnosed by nasal brush cytology.
  • Cytomorphologic findings common among the three cases included the presence of several cell types, including nasal cavity epithelial cells, histiocytes, phagocytic histiocytes, and lymphoid cells, within a necrotic background.
  • Suspected lymphoma cells were medium to large lymphoid cells possessing light blue and abundant cytoplasm.
  • We believe these intriguing cytologic findings are indicators of NK/T-cell lymphoma of the nasal type.
  • Immunocytochemical and molecular cytochemical analyses showed staining for natural killer cell antigen CD56 as well as cytotoxic granule-associated proteins granzyme B7 (GrB7) and T-cell-restricted intercellular antigen-1 (TIA-1).
  • Comparison between cytobrush and cotton swab methodology showed that cytobrush resulted in more cell-rich specimens than did cotton swabs, suggesting that nasal brush cytology with cytobrush is most useful in the diagnosis of NK/T-cell lymphoma of the nasal type.
  • [MeSH-major] Killer Cells, Natural / pathology. Lymphoma, T-Cell / diagnosis. Nose Neoplasms / diagnosis

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  • (PMID = 17230578.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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19. Tang QL, Liu WP, Zhang WY, Yang F, He MX, Xia QJ, Li GD: [Expression of CYR61 and VEGF in extranodal nasal-type NK/T cell lymphoma and their significances]. Zhonghua Xue Ye Xue Za Zhi; 2006 Oct;27(10):661-5
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  • [Title] [Expression of CYR61 and VEGF in extranodal nasal-type NK/T cell lymphoma and their significances].
  • OBJECTIVE: To investigate the expression of CYR61 and VEGF in extranodal nasal-type NK/T cell lymphoma and its significance.
  • METHODS: CYR61 mRNA and VEGF mRNA were detected by real-time fluorescence quantitative PCR method in 20 cases of extranodal nasal-type NK/T cell lymphoma.
  • CONCLUSION: In extranodal nasal-type NK/T cell lymphoma, the expression level of CYR61 and VEGF was changed and it may be of prognostic implication of
  • [MeSH-major] Immediate-Early Proteins / biosynthesis. Intercellular Signaling Peptides and Proteins / biosynthesis. Lymphoma, T-Cell / metabolism. Nose Neoplasms / metabolism. Vascular Endothelial Growth Factor A / biosynthesis
  • [MeSH-minor] Adolescent. Adult. Aged. Cysteine-Rich Protein 61. Female. Humans. Killer Cells, Natural. Male. Middle Aged. Polymerase Chain Reaction. RNA, Messenger / biosynthesis

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  • (PMID = 17343196.001).
  • [ISSN] 0253-2727
  • [Journal-full-title] Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
  • [ISO-abbreviation] Zhonghua Xue Ye Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / CYR61 protein, human; 0 / Cysteine-Rich Protein 61; 0 / Immediate-Early Proteins; 0 / Intercellular Signaling Peptides and Proteins; 0 / RNA, Messenger; 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A
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20. Kim SJ, Oh SY, Hong JY, Chang MH, Lee DH, Huh J, Ko YH, Ahn YC, Kim HJ, Suh C, Kim K, Kim WS: When do we need central nervous system prophylaxis in patients with extranodal NK/T-cell lymphoma, nasal type? Ann Oncol; 2010 May;21(5):1058-63
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  • [Title] When do we need central nervous system prophylaxis in patients with extranodal NK/T-cell lymphoma, nasal type?
  • BACKGROUND: The incidence and risk factors of central nervous system (CNS) invasion is still unclear in extranodal natural killer (NK)/T-cell lymphoma, nasal type.
  • PATIENTS AND METHODS: We analyzed 208 patients to study the clinical features and outcomes of CNS disease in extranodal NK/T-cell lymphoma.
  • The clinical variables associated with CNS disease were Ann Arbor stage III/IV (15.87%, P <0.001), regional lymph node involvement (10.41%, P = 0.006), group III/IV of NK/T-cell lymphoma prognostic index (NKPI; 10.20%, P = 0.003), high/high-intermediate international prognostic index (9.30%, P = 0.072) and extra-upper aerodigestive primary sites (9.75%, P = 0.008).
  • In multivariate analysis, NKPI retained the strongest statistical power to predict CNS disease (P = 0.007, relative risk 9.289, 95% confidence interval 1.828-47.212) in extranodal NK/T-cell lymphoma.
  • CONCLUSIONS: Despite extranodal NK/T-cell lymphoma frequently involves paranasal sinus, a routine CNS evaluation and prophylaxis do not seem to be necessary in NKPI group I or II patients due to a very low incidence.

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  • (PMID = 19850636.001).
  • [ISSN] 1569-8041
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] England
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21. Min HS, Hyun CL, Paik JH, Jeon YK, Choi G, Park SH, Seo JW, Kim CW: An autopsy case of aggressive CD30+ extra-nodal NK/T-cell lymphoma initially manifested with granulomatous myositis. Leuk Lymphoma; 2006 Feb;47(2):347-52
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  • [Title] An autopsy case of aggressive CD30+ extra-nodal NK/T-cell lymphoma initially manifested with granulomatous myositis.
  • This study reports an autopsy case of a 53 year-old male with rapidly progressive extra-nodal NK/T-cell lymphoma accompanied with unusual clinical and pathologic features.
  • He was initially presented with localized swelling and tenderness in the right lower extremity and the biopsy from the calf muscle was interpreted as granulomatous myositis masquerizing lymphoma.
  • The biopsy from erythematous skin lesion of trunk showed infiltration of medium sized atypical lymphoid cells with relatively plump cytoplasm and immunophenotype of CD30+, CD56+/- and surface CD3-, which lead to the diagnosis of CD30+ anaplastic large cell lymphoma.
  • About 2 months later, nasal obstruction was developed and the nasal biopsy was done.
  • After confirmation of EBV infection, he was finally diagnosed as extra-nodal NK/T-cell lymphoma with peculiar immunophenotype of CD3 dim+ and CD30+.
  • At autopsy, disseminated angiocentric lymphoma was found all over the internal organs including the brain.
  • This case emphasizes that extra-nodal NK/T-cell lymphoma should be considered as a cause of granulomatous myositis and can express CD30 positivity and CD3 weak positivity, which are unusual but rarely predominant feature of NK/T-cell lymphoma.
  • [MeSH-major] Antigens, CD30 / immunology. Granuloma / pathology. Killer Cells, Natural / pathology. Lymphoma, T-Cell / pathology. Myositis / pathology

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  • (PMID = 16321870.001).
  • [ISSN] 1042-8194
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD3; 0 / Antigens, CD30; 0 / CD3 antigen, zeta chain
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22. Zhao S, Liu WP, Li GD, Zhang WY: [Detecting LMP1 protein expression and cloning full-length LMP1 gene in extranodal nasal type NK/T-cell lymphoma transplanted tumor models]. Sichuan Da Xue Xue Bao Yi Xue Ban; 2005 Sep;36(5):657-60
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  • [Title] [Detecting LMP1 protein expression and cloning full-length LMP1 gene in extranodal nasal type NK/T-cell lymphoma transplanted tumor models].
  • OBJECTIVE: To assess the stability and variability of the LMP1 gene and protein in nude-mice transplanted tumor models of extranodal nasal type NK/T-cell lymphoma.
  • METHODS: PCR and Western Blot were performed to detect the full-length LMP1 gene and protein expression in the established extranodal nasal type NK/ T-cell lymphoma transplanted tumor models and the tissues of donor tumors.
  • Then the sequence of full-length LMP1 gene in transplanted tumor models and donor were compared with the sequence of wild-type B95.
  • 8 and deletion-type CAO cell strains.
  • RESULTS: LMP1 gene and protein were detected in all the extranodal nasal type NK/T-cell lymphoma transplanted tumor models, and the full-length LMP1 nucleotide sequence homology with the donor tumor was 99. 76%.
  • It was found in sequencing analysis that LMP1 gene sequence possessed both conservative character and specificity, similar to that of CAO cell strains.
  • CONCLUSION: LMP1 gene and protein existed stably in the extranodal nasal type NK/T-cell lymphoma transplanted tumor models, which implied that LMP1 might relate to the maintenance and development of this lymphoma.
  • The nude-mice transplanted tumor models provided an important experimental platform for further studies on the correlation of LMP1 and extranodal nasal type NK/T-cell lymphoma.
  • [MeSH-major] Lymphoma, T-Cell / metabolism. Nose Neoplasms / metabolism. Viral Matrix Proteins / analysis. Viral Matrix Proteins / genetics

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  • (PMID = 16235530.001).
  • [ISSN] 1672-173X
  • [Journal-full-title] Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
  • [ISO-abbreviation] Sichuan Da Xue Xue Bao Yi Xue Ban
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / EBV-associated membrane antigen, Epstein-Barr virus; 0 / Viral Matrix Proteins
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23. Na II, Kang HJ, Park YH, Lee SS, Yoo HJ, Choe DH, Ryoo BY, Yang SH: Prognostic factors for classifying extranodal NK/T cell lymphoma, nasal type, as lymphoid neoplasia. Eur J Haematol; 2007 Jul;79(1):1-7
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  • [Title] Prognostic factors for classifying extranodal NK/T cell lymphoma, nasal type, as lymphoid neoplasia.
  • This study evaluated the applicability of prognostic factors commonly used for diagnosis of classical lymphoma outcomes to extranodal NK/T cell lymphoma, nasal type (NTCL).
  • [MeSH-major] Killer Cells, Natural / immunology. Lymphoma, T-Cell / classification. Nose Neoplasms / classification

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  • (PMID = 17598834.001).
  • [ISSN] 0902-4441
  • [Journal-full-title] European journal of haematology
  • [ISO-abbreviation] Eur. J. Haematol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] EC 1.1.1.27 / L-Lactate Dehydrogenase
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24. Liang R: Advances in the management and monitoring of extranodal NK/T-cell lymphoma, nasal type. Br J Haematol; 2009 Oct;147(1):13-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Advances in the management and monitoring of extranodal NK/T-cell lymphoma, nasal type.
  • Extranodal natural killer (NK)/T-cell lymphoma, nasal type, has a unique geographic distribution.
  • A typical NK-cell phenotype is usually present: CD2(+), CD3 epsilon+, CD56(+), cytotoxic molecules+ and Epstein-Barr virus (EBV)+.
  • For localized nasal disease, radiotherapy is important, although chemotherapy is often added.
  • For extra-nasal or disseminated disease, systemic chemotherapy becomes the mainstay and the prognosis is usually poor.
  • Patients with poor prognostic features may be considered for an early autologous haematopoietic stem cell transplant.
  • [MeSH-major] Lymphoma, Extranodal NK-T-Cell / therapy. Nose Neoplasms / therapy
  • [MeSH-minor] Combined Modality Therapy. Hematopoietic Stem Cell Transplantation. Humans. Neoplasm Staging

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  • (PMID = 19604234.001).
  • [ISSN] 1365-2141
  • [Journal-full-title] British journal of haematology
  • [ISO-abbreviation] Br. J. Haematol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Number-of-references] 83
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25. Xiao J, Wang SS, Huang Y, Chen LK, Guan ZZ, Huang HQ, Xia ZJ, Xu RH, Lin TY: [Prognostic analysis of 62 cases of nasal NK/T-cell lymphoma]. Ai Zheng; 2006 Sep;25(9):1173-7
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  • [Title] [Prognostic analysis of 62 cases of nasal NK/T-cell lymphoma].
  • BACKGROUND & OBJECTIVE: Extranodal NK/T-cell lymphoma of nasal type (ENKTL) is a rare disease entity with unique biological behavior, of which definitive characteristics are still unknown.
  • [MeSH-major] Killer Cells, Natural. Lymphoma, T-Cell / therapy. Nose Neoplasms / therapy

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  • (PMID = 16965665.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Hemoglobins; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CHOP protocol
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26. Bang SM, Kim YK, Park YH, Sohn SK, Lee JJ, Cho EK, Ryoo BY, Chung IJ, Yoon SS, Kim HJ, Lee JH, Yoon HJ, Park S: High-dose therapy and autologous stem cell transplantation in Korean patients with aggressive T/NK-cell lymphoma. Leuk Lymphoma; 2005 Nov;46(11):1599-1604
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  • [Title] High-dose therapy and autologous stem cell transplantation in Korean patients with aggressive T/NK-cell lymphoma.
  • The proportion of aggressive T/NK-cell lymphoma in Korea is larger than in the West, and it shows a lower response to conventional chemotherapy and poorer survival than diffuse large B-cell lymphoma.
  • This study was undertaken to evaluate the response rate and survival and to document the prognostic factors in patients with T/NK-cell lymphoma who have undergone high-dose therapy (HDT).
  • Eligibility for the study was a mature T/NK-cell lymphoma with initially poor risk (as high or high intermediate risk on age-adjusted International Prognostic Index) or relapsed cases.
  • Twelve patients had unspecified peripheral T-cell lymphomas, 7 anaplastic large-cell lymphomas, 6 nasal T/NK-cell lymphomas, and 3 angioimmunoblastic T-cell lymphomas.
  • Absolute neutrophil count ( > 500/microl) recovered at a median 11 days after autologous stem cell transplantation in 26 patients.
  • Therefore, an initial approach with effective induction and HDT may result in a better outcome in T/NK-cell lymphoma.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Hematopoietic Stem Cell Transplantation / methods. Killer Cells, Natural / pathology. Lymphoma, T-Cell / therapy

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  • (PMID = 16334486.001).
  • [ISSN] 1042-8194
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] England
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27. Shim SJ, Yang WI, Shin E, Koom WS, Kim YB, Cho JH, Suh CO, Kim JH, Kim GE: Clinical significance of cyclooxygenase-2 expression in extranodal natural killer (NK)/T-cell lymphoma, nasal type. Int J Radiat Oncol Biol Phys; 2007 Jan 1;67(1):31-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical significance of cyclooxygenase-2 expression in extranodal natural killer (NK)/T-cell lymphoma, nasal type.
  • PURPOSE: To determine whether there are any differences in therapeutic response, patterns of systemic recurrence, and prognosis of patients with extranodal natural killer (NK)/T-cell lymphoma, nasal type, by the cyclooxygenase-2 (COX-2) expression.
  • PATIENTS AND METHODS: Thirty-four patients with Ann Arbor Stage I and II extranodal NK/T-cell lymphoma who underwent chemotherapy or radiotherapy, or both, were retrospectively reviewed.
  • These patients were divided into two groups according to their immunohistochemical staining for COX-2 expressions: a COX-2-negative group (n = 10 patients) and a COX-2-positive group (n = 24 patients).
  • Compared with the patients in the COX-2-negative group, those in the COX-2-positive group had a significantly lower 2-year systemic recurrence-free survival rate (100% for the COX-2-negative group vs. 54% for the COX-2-positive group) (p = 0.02) and a decreased 5-year overall survival rate (70% for the COX-2-negative group vs. 32% for the COX-2-positive group) (p = 0.06).
  • CONCLUSION: Cyclooxygenase-2 expression can serve as a predictive factor for poor treatment response, higher systemic recurrence, and unfavorable prognosis in patients with extranodal NK/T-cell lymphoma, nasal type.
  • [MeSH-major] Cyclooxygenase 2 / metabolism. Head and Neck Neoplasms / metabolism. Lymphoma, T-Cell / metabolism. Neoplasm Proteins / metabolism

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  • (PMID = 17049184.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Neoplasm Proteins; EC 1.14.99.1 / Cyclooxygenase 2
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28. Wang Z: [Nasal extranodal NK/T cell lymphoma: terminologic evaluation and diagnostic problems]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2010 Sep;24(17):791-4
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  • [Title] [Nasal extranodal NK/T cell lymphoma: terminologic evaluation and diagnostic problems].
  • OBJECTIVE: To review on the evolution in the understanding of midline destructive lesions of the sinonasal tract in different period, and to describe the clinical features and diagnostic problems on the nasal extranodal NK/T cell lymphoma (NENKTCL).
  • METHOD: To retrospectively study the nasal CT scannings and the results of serum ANCA of 10 patients with typical clinical characteristics.
  • RESULT: All patients presented with the symptoms of the nasal obstruction and the nasal discharge.
  • Nasal endoscopy and CT scan of paranasal sinuses showed destructive sinonasal lesions.
  • Clinically, Nasal lesions in the cases were similar to those from historical nomenclature.
  • [MeSH-major] Lymphoma, Extranodal NK-T-Cell / diagnosis. Nose Neoplasms / diagnosis

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  • (PMID = 21090103.001).
  • [ISSN] 1001-1781
  • [Journal-full-title] Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
  • [ISO-abbreviation] Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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29. Zhao S, Liu WP, Zhang WY, Li GD: [Extranodal nasal type NK/T-cell lymphoma: the expression of Epstein-Barr virus latent membrane protein 1 and its significance of prognosis]. Sichuan Da Xue Xue Bao Yi Xue Ban; 2005 May;36(3):338-40
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  • [Title] [Extranodal nasal type NK/T-cell lymphoma: the expression of Epstein-Barr virus latent membrane protein 1 and its significance of prognosis].
  • To investigate the expression and prognostic significance of Epstein-Barr virus latent membrane protein 1 in extranodal nasal type NK/T-cell lymphoma in the Chengdu area.
  • METHODS: The expression of latent membrane protein-1 (LMP1) was detected by immunohistochemistry (IHC) and DNA-PCR in 67 cases of extranodal nasal type NK/T-cell lymphoma, and the differences in survival rate between positive and negative expression groups of LMP1-protien and LMP1-DNA were analyzed respectively.
  • CONCLUSION: LMP1 was shown to be closely associated with extranodal nasal type NK/T-cell lymphoma in Chengdu.
  • No relationship was found between the prognosis and the LMP1 expression in extranodal nasal type NK/T-cell lymphoma.
  • [MeSH-major] Epstein-Barr Virus Infections / virology. Lymphoma, T-Cell / virology. Nose Neoplasms / virology. Viral Matrix Proteins / biosynthesis

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  • (PMID = 15931862.001).
  • [ISSN] 1672-173X
  • [Journal-full-title] Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
  • [ISO-abbreviation] Sichuan Da Xue Xue Bao Yi Xue Ban
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / EBV-associated membrane antigen, Epstein-Barr virus; 0 / Viral Matrix Proteins; 0 / Viral Proteins
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30. Kim SJ, Kim BS, Choi CW, Choi J, Kim I, Lee YH, Kim JS: Ki-67 expression is predictive of prognosis in patients with stage I/II extranodal NK/T-cell lymphoma, nasal type. Ann Oncol; 2007 Aug;18(8):1382-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ki-67 expression is predictive of prognosis in patients with stage I/II extranodal NK/T-cell lymphoma, nasal type.
  • BACKGROUND: Localized extranodal natural killer (NK)/T-cell lymphoma, nasal type, commonly has a low or low-intermediate risk of the international prognostic index (IPI), so the IPI has shown inconsistency in predicting prognosis.
  • Thus, we analyzed Ki-67 expression and proposed a new prognostic model including Ki-67 expression for stage I/II extranodal NK/T-cell lymphoma.
  • PATIENTS AND METHODS: We studied Ki-67 expression and its relationship with prognosis in 50 patients with extranodal NK/T-cell lymphoma.
  • CONCLUSIONS: Ki-67 expression is predictive of prognosis, and our prognostic model may become a useful tool for predicting prognosis in patients with stage I/II extranodal NK/T-cell lymphoma, nasal type.

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  • (PMID = 17693651.001).
  • [ISSN] 0923-7534
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Ki-67 Antigen
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31. Tardío JC, Moreno A, Pérez C, Hernández-Rivas JA, López-Carreira M: Primary laryngeal T/NK-cell lymphoma, nasal-type: an unusual location for an aggressive subtype of extranodal lymphoma. Eur Arch Otorhinolaryngol; 2008 Jun;265(6):705-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary laryngeal T/NK-cell lymphoma, nasal-type: an unusual location for an aggressive subtype of extranodal lymphoma.
  • Most of them are extramedullary plasmocytomas, diffuse large B-cell lymphomas, or MALT-type marginal zone B-cell lymphomas.
  • T- or NK-cell lymphomas have rarely been reported in this location.
  • The diagnosis of laryngeal lymphomas is a challenge, due to the absence of clinical and gross differential criteria.
  • We present hereby a primary laryngeal T/NK-cell lymphoma, nasal-type.
  • Polychemotherapy was administrated with initial partial response, but rapid local progression and exitus followed six months after the diagnosis.
  • The extranodal T/NK-cell lymphoma, nasal-type is a very aggressive subtype of extranodal lymphoma, usually located in the nasal cavity or in nearby sites.
  • The prognosis of extranasal cases of this type of lymphoma is poor, even when they are diagnosed in localized stages.
  • [MeSH-major] Killer Cells, Natural / pathology. Laryngeal Neoplasms / diagnosis. Lymphoma, T-Cell, Peripheral / diagnosis
  • [MeSH-minor] Adult. Antineoplastic Agents / therapeutic use. Biopsy. Diagnosis, Differential. Fatal Outcome. Humans. Laryngoscopy. Male. Severity of Illness Index. Tomography, X-Ray Computed

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  • (PMID = 17955253.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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32. Brodkin DE, Hobohm DW, Nigam R: Nasal-type NK/T-cell lymphoma presenting as hemophagocytic syndrome in an 11-year-old Mexican boy. J Pediatr Hematol Oncol; 2008 Dec;30(12):938-40
MedlinePlus Health Information. consumer health - Nasal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nasal-type NK/T-cell lymphoma presenting as hemophagocytic syndrome in an 11-year-old Mexican boy.
  • Recently established by the World Health Organization classification, "nasal" and "nasal-type" NK/T-cell lymphoma arise from natural killer (NK) cells.
  • They have distinct clinicopathologic features, specific genotype and phenotype, and a high association with Epstein-Barr virus infection.
  • Nasal-type NK/T-cell lymphoma arise from extranasal sites including skin, soft tissue, gastrointestinal tract, liver, spleen, testes, lung, and central nervous system.
  • We report an 11-year-old child with extranodal nasal-type NK/T-cell lymphoma presenting as hemophagocytic syndrome and multiorgan system failure with fatal outcome.
  • [MeSH-major] Killer Cells, Natural / pathology. Lymphohistiocytosis, Hemophagocytic / diagnosis. Lymphoma, T-Cell / diagnosis. Nose Neoplasms / diagnosis
  • [MeSH-minor] Child. Diagnosis, Differential. Fatal Outcome. Humans. Male. Mexico. Multiple Organ Failure / diagnosis. Multiple Organ Failure / etiology

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  • (PMID = 19131786.001).
  • [ISSN] 1536-3678
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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33. Lee J, Park YH, Kim WS, Lee SS, Ryoo BY, Yang SH, Park KW, Kang JH, Park JO, Lee SH, Kim K, Jung CW, Park YS, Im YH, Kang WK, Lee MH, Ko YH, Ahn YC, Park K: Extranodal nasal type NK/T-cell lymphoma: elucidating clinical prognostic factors for risk-based stratification of therapy. Eur J Cancer; 2005 Jul;41(10):1402-8
MedlinePlus Health Information. consumer health - Nasal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extranodal nasal type NK/T-cell lymphoma: elucidating clinical prognostic factors for risk-based stratification of therapy.
  • The purpose of this study was to define distinctive clinical features of "nasal" and "nasal-type" NK/T cell lymphomas by assessing prognostic factors.
  • The anatomic definition of extranasal NK/T cell lymphoma has been vague resulting in variable definitions of extranasal sites by different groups.
  • We analysed the clinical behavior of 90 NK/T cell lymphoma patients and attempted to elucidate the prognostic factors for risk-based stratification of therapy.
  • We observed no significant difference between "nasal" and "nasal-type" NK/T cell lymphomas in regards to clinical features and survival using the conventional anatomic classification.
  • We suggest the categorisation of the two subtypes of NK/T cell lymphoma as follows: UNKTL (upper aerodigestive tract NK/T cell lymphoma) including all lymphomas confined to nasal cavity, nasopharynx, and the upper aerodigestive tract and EUNKTL (extra-upper aerodigestive tract NK/T cell lymphoma) group to include all sites other than the UNKTL group.
  • The EUNKTL group in this study had advanced stage at diagnosis, higher LDH, higher IPI score, poorer performance and inferior response to the anthracycline-based chemotherapy with statistical significance.
  • [MeSH-major] Killer Cells, Natural / pathology. Lymphoma, T-Cell / pathology. Nose Neoplasms / pathology

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  • (PMID = 15963893.001).
  • [ISSN] 0959-8049
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
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34. Zhao S, Liu WP, Wang XL, Zhang WY, Jiang W, Tang Y, Li GD: [Detection of the 30 base pair deletion of Epstein-Barr virus latent membrane protein 1 in extranodal nasal type NK/T-cell lymphoma and its prognostic significance]. Zhonghua Bing Li Xue Za Zhi; 2005 Nov;34(11):720-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Detection of the 30 base pair deletion of Epstein-Barr virus latent membrane protein 1 in extranodal nasal type NK/T-cell lymphoma and its prognostic significance].
  • OBJECTIVE: To compare the detection rate of Epstein-Barr virus latent membrane protein 1 (LMP1) 30 base pair deletion in extranodal nasal type NK/T-cell lymphoma with that in chronic inflammation of nasopharynx and tonsillitis; and to analyze the prognostic significance of LMP1 deletion in extranodal nasal type NK/T-cell lymphoma.
  • METHODS: Polymerase chain reaction was used to detect the deletion of LMP1 in 55 cases of extranodal nasal type NK/T-cell lymphoma and 19 cases of chronic inflammation of nasopharynx and tonsillitis.
  • RESULTS: In all the 55 extranodal nasal type NK/T-cell lymphoma cases studied, 9 cases contained the wide-type or predominantly wide-type LMP1.
  • In the non-lymphoma control group, 16 cases contained the deleted or predominantly deleted LMP1.
  • However, no statistically significant difference was found in the detection rate of 30 base pair deleted LMP1 between extranodal nasal type NK/T-cell lymphoma and control group (P > 0.05).
  • The prognosis of deleted or predominantly deleted LMP1 in extranodal nasal type NK/T-cell lymphoma was worse.
  • CONCLUSION: Though 30 base pair deletion of Epstein-Barr virus LMP1 may not be an important pathogenetic step in extranodal nasal type NK/T-cell lymphoma, it may play some role in tumor progression.
  • [MeSH-major] Lymphoma, T-Cell, Peripheral / genetics. Nose Neoplasms / genetics. Sequence Deletion. Viral Matrix Proteins / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Base Sequence. Epstein-Barr Virus Infections / genetics. Epstein-Barr Virus Infections / virology. Female. Follow-Up Studies. Herpesvirus 4, Human / genetics. Humans. Killer Cells, Natural / pathology. Killer Cells, Natural / virology. Male. Middle Aged. Nasopharyngitis. Survival Rate. Tonsillitis / genetics. Tonsillitis / virology

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  • (PMID = 16536316.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / EBV-associated membrane antigen, Epstein-Barr virus; 0 / Viral Matrix Proteins
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35. Suzuki R, Takeuchi K, Ohshima K, Nakamura S: Extranodal NK/T-cell lymphoma: diagnosis and treatment cues. Hematol Oncol; 2008 Jun;26(2):66-72

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extranodal NK/T-cell lymphoma: diagnosis and treatment cues.
  • Extranodal NK/T-cell lymphoma, nasal type (ENKL) is mostly endemic to East Asia.
  • It predominantly occurs in the nasal or paranasal areas and less frequently in the skin.
  • Most of the tumours show NK-cell, but rarely T-cell, phenotypes.
  • The Epstein-Barr virus (EBV) genome can be usually detected in lymphoma cells.
  • Originally, NK-cell and T-cell types were believed to present the same clinicopathologic characteristics, but recent data suggest more aggressive characteristics for the NK-cell phenotype.
  • Although ENKL is sensitive to radiotherapy, it shows a poorer response to chemotherapeutic agents than other lymphomas due to expression of p-glycoprotein.
  • [MeSH-major] Killer Cells, Natural / cytology. Lymphoma, T-Cell, Peripheral / diagnosis. Lymphoma, T-Cell, Peripheral / therapy
  • [MeSH-minor] Antigens, CD56 / biosynthesis. Antineoplastic Agents / pharmacology. Biopsy. Epstein-Barr Virus Infections / complications. Hematopoietic Stem Cell Transplantation. Herpesvirus 4, Human / metabolism. Humans. Immunophenotyping. Medical Oncology / methods. Models, Biological. P-Glycoprotein / metabolism. Phenotype. Treatment Outcome

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  • (PMID = 18283711.001).
  • [ISSN] 0278-0232
  • [Journal-full-title] Hematological oncology
  • [ISO-abbreviation] Hematol Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD56; 0 / Antineoplastic Agents; 0 / P-Glycoprotein
  • [Number-of-references] 74
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36. Kim SJ, Kim WS: Treatment of localized extranodal NK/T cell lymphoma, nasal type. Int J Hematol; 2010 Dec;92(5):690-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Treatment of localized extranodal NK/T cell lymphoma, nasal type.
  • Extranodal NK/T cell lymphoma predominantly presents as a localized disease in the upper aerodigestive tract from the nasal cavity to the hypopharynx.
  • Likewise, for patients with poor prognostic factors, such as a high NK lymphoma prognostic index, autologous stem cell transplantation during remission and additional treatments with central nervous system prophylaxis may be beneficial.
  • [MeSH-major] Lymphoma, Extranodal NK-T-Cell / therapy
  • [MeSH-minor] Drug Therapy. Humans. Neoplasms, Second Primary / prevention & control. Radiotherapy. Salvage Therapy. Stem Cell Transplantation. Transplantation, Autologous. Treatment Outcome

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  • (PMID = 21086194.001).
  • [ISSN] 1865-3774
  • [Journal-full-title] International journal of hematology
  • [ISO-abbreviation] Int. J. Hematol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
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37. Meng W, Zhou Y, Zhang H, Jiang L, Wang Z, Li X, Zhou H, Chen Q, Zeng X: Nasal-type NK/T-cell lymphoma with palatal ulcer as the earliest clinical manifestation: a case report with literature review. Pathol Oncol Res; 2010 Mar;16(1):133-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nasal-type NK/T-cell lymphoma with palatal ulcer as the earliest clinical manifestation: a case report with literature review.
  • Extranodal nasal natural killer (NK)/T-cell lymphoma is a very rare kind of lymphoma, Oral cavity involvement of extranodal natural killer/T-cell lymphoma, nasal type is extremely rare, and its clinicopathologic features are also poorly understood.
  • Recently, we experienced an unusual case of Epstein-Barr virus-associated, extranodal NK/T-cell type with a unhealed palatal ulcer as the earliest clinical feature.
  • It is a challenge for oral medicine specialists to make the early diagnosis for this special type of tumor.
  • [MeSH-major] Lymphoma, Extranodal NK-T-Cell / pathology. Mouth Neoplasms / pathology. Palate / pathology. Ulcer / pathology

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  • (PMID = 19590983.001).
  • [ISSN] 1532-2807
  • [Journal-full-title] Pathology oncology research : POR
  • [ISO-abbreviation] Pathol. Oncol. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 13
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38. Kim SJ, Kim BS, Choi CW, Seo HY, Seol HR, Sung HJ, Kim IS, Kim CY, Jung KY, Kim JS: Treatment outcome of front-line systemic chemotherapy for localized extranodal NK/T cell lymphoma in nasal and upper aerodigestive tract. Leuk Lymphoma; 2006 Jul;47(7):1265-73
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Treatment outcome of front-line systemic chemotherapy for localized extranodal NK/T cell lymphoma in nasal and upper aerodigestive tract.
  • We analysed the treatment outcome of localized extranodal NK/T cell lymphoma initially treated with CEOP-B chemotherapy based on the primary site of involvement (nasal cavity vs. upper aerodigestive tract) and treatment modality (chemotherapy vs. chemotherapy followed by radiotherapy.
  • Forty-three patients newly diagnosed as extranodal NK/T cell lymphoma were analysed: 29 cases from nasal cavity/nasopharynx and 14 from upper aerodigestive tract.
  • There may be a tendency for better overall survival in group of upper aerodigestive tract lymphoma than the nasal cavity/nasopharynx group (P = 0.0643).
  • However, front-line CEOP-B chemotherapy has a limited role and adjuvant radiotherapy failed to improve survival in localized extranodal NK/T cell lymphoma.
  • [MeSH-major] Antineoplastic Agents / pharmacology. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Killer Cells, Natural / cytology. Lymphoma, T-Cell / drug therapy. Lymphoma, T-Cell / pathology

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  • (PMID = 16923556.001).
  • [ISSN] 1042-8194
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 11056-06-7 / Bleomycin; 3Z8479ZZ5X / Epirubicin; 5J49Q6B70F / Vincristine; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CEOP-B protocol
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39. Wang TT, Wang Z: [Recent advances on extranodal NK/T-cell lymphoma of nasal type]. Zhongguo Shi Yan Xue Ye Xue Za Zhi; 2009 Dec;17(6):1624-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Recent advances on extranodal NK/T-cell lymphoma of nasal type].
  • Extranodal NK/T-cell lymphoma, nasal type (ENKT), is a distinct clinicopathologic disease, common among East Asia and Latin America population.
  • It predominantly occurs in the nasal or paranasal areas and less frequently in the skin.
  • The main clinical features are nasal congestion, sore throat, dysphagia and epistaxis, due to a destructive mass involving the midline facial tissues.
  • Pathologically, lymphoma cells exhibit angioinvasion, angiodestruction and coagulative necrosis.
  • In this review, the recent advances on cause and pathogenesis, clinical manifestations and staging, pathologic characteristics, diagnosis and differential diagnosis, therapy and prognosis of ENKL are summarized.

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  • (PMID = 20030961.001).
  • [ISSN] 1009-2137
  • [Journal-full-title] Zhongguo shi yan xue ye xue za zhi
  • [ISO-abbreviation] Zhongguo Shi Yan Xue Ye Xue Za Zhi
  • [Language] CHI
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] China
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40. Schwartz EJ, Molina-Kirsch H, Zhao S, Marinelli RJ, Warnke RA, Natkunam Y: Immunohistochemical characterization of nasal-type extranodal NK/T-cell lymphoma using a tissue microarray: an analysis of 84 cases. Am J Clin Pathol; 2008 Sep;130(3):343-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistochemical characterization of nasal-type extranodal NK/T-cell lymphoma using a tissue microarray: an analysis of 84 cases.
  • Nasal-type extranodal natural killer (NK)/T-cell lymphoma is an uncommon malignancy.
  • By using a tissue microarray, we characterized 84 cases of extranodal NK/T-cell lymphoma with regard to expression of 18 immunohistochemical markers and the presence of Epstein-Barr virus (EBV) RNA.
  • Hierarchical cluster analysis separated primary cutaneous cases from cases manifesting in other sites based on lower expression of the cell adhesion molecule CD54.
  • [MeSH-major] Epstein-Barr Virus Infections / pathology. Immunohistochemistry / methods. Lymphoma, T-Cell, Peripheral / pathology. Nose Neoplasms / pathology
  • [MeSH-minor] Antigens, CD45 / biosynthesis. Herpesvirus 4, Human. Humans. In Situ Hybridization. Killer Cells, Natural / pathology. Microarray Analysis. RNA, Viral / analysis. T-Lymphocytes, Cytotoxic / pathology

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  • (PMID = 18701406.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA34233
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Viral; EC 3.1.3.48 / Antigens, CD45; EC 3.1.3.48 / PTPRC protein, human
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41. Kanitsap N, Warnnissorn N: NK/T cell lymphoma, nasal type with sinonasal mass and palatal ulcer: a clinical case report and review of treatment. J Med Assoc Thai; 2010 Dec;93 Suppl 7:S294-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] NK/T cell lymphoma, nasal type with sinonasal mass and palatal ulcer: a clinical case report and review of treatment.
  • Extranodal Nasal NK/T cell lymphoma, relatively uncommon type of non-Hodgkin's lymphoma, is highly aggressive disease with poor outcomes.
  • We reported a 45-year-old woman with extranodal nasal type NK/T cell lymphoma.
  • The patient presented with chronic nasal stuffiness and mucous bloody discharge.
  • The nasal mass is extensively involved periorbital and sinonasal soft tissue.
  • The salvage chemotherapy was given and the treatment of NK/T cell lymphoma from other reports and literatures were reviewed.
  • [MeSH-major] Killer Cells, Natural / pathology. Nose Neoplasms / pathology. Oral Ulcer / radiography. Salvage Therapy

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  • (PMID = 21294428.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Thailand
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42. Zhao S, Tang QL, He MX, Yang F, Wang H, Zhang WY, Jiang W, Wang XL, Mo XM, Li GD, Liu WP: A novel nude mice model of human extranodal nasal type NK/T-cell lymphoma. Leukemia; 2008 Jan;22(1):170-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A novel nude mice model of human extranodal nasal type NK/T-cell lymphoma.
  • A novel nude mice model of human extranodal nasal type NK/T-cell lymphoma was established by subcutaneously implanting the sample taken from the patient with secondary extranodal nasal type NK/T-cell lymphoma of the stomach into the right axillary region of a BALB/c (nu/nu) nude mouse.
  • Histologically, the tumor cells were medium to large size and arranged in sheets, with a little mesenchyma, and disseminated almost in all passages of the lymphoma-bearing nude mice.
  • No T-cell receptor gamma gene rearrangement was detected in the transplanted tumors.
  • The transplanted tumor in this novel nude mice model maintained the essential features of human extranodal nasal type NK/T-cell lymphoma, and it would be an ideal tool in vivo for further research of the tumor.
  • [MeSH-major] Disease Models, Animal. Killer Cells, Natural. Lymphoma, T-Cell / pathology. Nose Neoplasms / pathology

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  • (PMID = 17851553.001).
  • [ISSN] 1476-5551
  • [Journal-full-title] Leukemia
  • [ISO-abbreviation] Leukemia
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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43. Huang MJ, Jiang Y, Liu WP, Li ZP, Li M, Zhou L, Xu Y, Yu CH, Li Q, Peng F, Liu JY, Luo F, Lu Y: Early or up-front radiotherapy improved survival of localized extranodal NK/T-cell lymphoma, nasal-type in the upper aerodigestive tract. Int J Radiat Oncol Biol Phys; 2008 Jan 1;70(1):166-74

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Early or up-front radiotherapy improved survival of localized extranodal NK/T-cell lymphoma, nasal-type in the upper aerodigestive tract.
  • PURPOSE: To investigate the role of early or up-front radiotherapy (RT), the optimal RT dose required to achieve appropriate treatment outcome and prognostic factors for patients with localized extranodal NK/T-cell lymphoma, nasal-type, in the upper aerodigestive tract.
  • CONCLUSION: Early or up-front RT had an essential role in improved OS and DFS in patients with localized extranodal NK/T-cell lymphoma, nasal-type, in the upper aerodigestive tract.
  • [MeSH-major] Lymphoma, Extranodal NK-T-Cell / radiotherapy

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  • (PMID = 17919841.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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44. Berk V, Yildiz R, Akdemir UO, Akyurek N, Karabacak NI, Coskun U, Benekli M: Disseminated extranodal NK/T-cell lymphoma, nasal type, with multiple subcutaneous nodules: utility of 18F-FDG PET in staging. Clin Nucl Med; 2008 May;33(5):365-6
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  • [Title] Disseminated extranodal NK/T-cell lymphoma, nasal type, with multiple subcutaneous nodules: utility of 18F-FDG PET in staging.
  • A 49-year-old man presented with a left nasal cavity mass, biopsy of which revealed extranodal NK/T cell lymphoma.
  • A PET-CT scan showed increased F-18 FDG uptake in the nasal mass, anterior mediastinal lymph nodes, and multiple subcutaneous nodular deposits in the chest wall, gluteal region, and right femoral areas.
  • There is limited literature data on the use of the PET scan in the diagnosis and staging of extranodal nasal NK/T-cell lymphomas.
  • [MeSH-major] Fluorodeoxyglucose F18. Lymphoma, Extranodal NK-T-Cell / radionuclide imaging. Nose Neoplasms / radionuclide imaging. Positron-Emission Tomography / methods. Skin Neoplasms / radionuclide imaging

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  • (PMID = 18431160.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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45. Liu X, Wang B, Ma X, Guo Y: NF-kappaB activation through the alternative pathway correlates with chemoresistance and poor survival in extranodal NK/T-cell lymphoma, nasal type. Jpn J Clin Oncol; 2009 Jul;39(7):418-24
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  • [Title] NF-kappaB activation through the alternative pathway correlates with chemoresistance and poor survival in extranodal NK/T-cell lymphoma, nasal type.
  • The aim of our study was to determine the expression status and clinical significance of NF-kappaB in extranodal natural killer (NK)/T-cell lymphoma, nasal type.
  • METHODS: Tumor specimens from 23 patients with previously untreated NK/T-cell lymphoma initially treated with cyclophosphamide, vincristine, doxorubicin and prednisone (CHOP) or CHOP-based chemotherapy were examined by immunohistochemistry for three NF-kappaB subunits (p65, p50 and p52), which are involved in either the canonical or alternative pathway.
  • CONCLUSIONS: Our results suggest that NF-kappaB activation through the alternative pathway is frequently observed in NK/T-cell lymphoma and associated with chemoresistance and poor survival.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Lymphoma, Extranodal NK-T-Cell / metabolism. Lymphoma, Extranodal NK-T-Cell / mortality. NF-kappa B / metabolism. Nose Neoplasms / metabolism. Nose Neoplasms / mortality
  • [MeSH-minor] Adolescent. Adult. Aged. Cell Nucleus / metabolism. Cyclophosphamide / therapeutic use. Doxorubicin / therapeutic use. Drug Resistance, Neoplasm. Female. Humans. Immunoenzyme Techniques. Male. Middle Aged. Neoplasm Staging. Prednisolone / therapeutic use. Prognosis. Risk Factors. Signal Transduction. Survival Rate. Treatment Outcome. Vincristine / therapeutic use. Young Adult

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  • (PMID = 19395464.001).
  • [ISSN] 1465-3621
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / NF-kappa B; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; 9PHQ9Y1OLM / Prednisolone; VAP-cyclo protocol
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46. Monma F, Ueno S, Yamaguchi M, Tawara I, Miyazaki K, Nishii K, Nakase K, Katayama N: [Long-term remission of a nasal NK/T-cell lymphoma patient with massive involvement of the orbita and liver dysfunction]. Rinsho Ketsueki; 2009 Jan;50(1):44-8
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  • [Title] [Long-term remission of a nasal NK/T-cell lymphoma patient with massive involvement of the orbita and liver dysfunction].
  • Histopathologic examination of the biopsied right orbital tumor demonstrated extranodal NK/T-cell lymphoma, nasal-type.
  • There is no evidence of recurrence 56 months after diagnosis.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Liver Diseases / complications. Lymphoma, Extranodal NK-T-Cell / drug therapy. Lymphoma, Extranodal NK-T-Cell / radiotherapy. Nose Neoplasms / drug therapy. Nose Neoplasms / radiotherapy. Orbital Neoplasms / drug therapy. Orbital Neoplasms / radiotherapy

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  • (PMID = 19225229.001).
  • [ISSN] 0485-1439
  • [Journal-full-title] [Rinshō ketsueki] The Japanese journal of clinical hematology
  • [ISO-abbreviation] Rinsho Ketsueki
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 6PLQ3CP4P3 / Etoposide; 7S5I7G3JQL / Dexamethasone; EC 3.5.1.1 / Asparaginase
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47. Yokoyama H, Yamada MF, Ishizawa K, Yamamoto J, Tomiya Y, Harigae H, Kameoka J, Ichinohasama R, Sasaki T: Successful treatment of advanced extranodal NK/T cell lymphoma with unrelated cord blood transplantation. Tohoku J Exp Med; 2007 Apr;211(4):395-9
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  • [Title] Successful treatment of advanced extranodal NK/T cell lymphoma with unrelated cord blood transplantation.
  • Nasal natural killer (NK)/T cell lymphoma is a rare entity of non-Hodgkin's lymphoma which mostly occurs in East Asian countries.
  • Thus the prognosis of advanced NK/T cell lymphoma is generally poor, however, the promising results of allogeneic hematopoietic stem cell transplantation for advanced NK/T cell lymphoma have been recently reported.
  • In most of these cases, stem cell sources were human leukocyte antigen (HLA) matched donors and alternative sources were seldom used.
  • We report here a case of a 36-year-old woman who was diagnosed as having an extranodal NK/T cell lymphoma, nasal type.
  • Cord blood thus could be an appropriate stem cell source for patients with advanced NK/T lymphoma who have no HLA matched donors.
  • [MeSH-major] Cord Blood Stem Cell Transplantation. Lymphoma, T-Cell / therapy
  • [MeSH-minor] Adult. Female. Histocompatibility Testing. Humans. Killer Cells, Natural / pathology. Nose Neoplasms / pathology. Nose Neoplasms / therapy. Tissue Donors

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  • (PMID = 17409680.001).
  • [ISSN] 0040-8727
  • [Journal-full-title] The Tohoku journal of experimental medicine
  • [ISO-abbreviation] Tohoku J. Exp. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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48. Li L, Liu YH, Zhuang HG, Luo XL, Zhang F, Xu FP, Luo DL: [Extranodal nasal type NK/T-cell lymphoma: clinicopathologic and prognostic study of 55 cases]. Zhonghua Bing Li Xue Za Zhi; 2009 Apr;38(4):237-42
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  • [Title] [Extranodal nasal type NK/T-cell lymphoma: clinicopathologic and prognostic study of 55 cases].
  • OBJECTIVE: To study the clinicopathologic features and prognostic factors of extranodal nasal type NK/T-cell lymphoma (EN-NK/TCL) in Chinese patients.
  • METHODS: Fifty-five cases of EN-NK/TCL diagnosed in Chinese patients during the period from 1998 to 2007 were studied by light microscopy, immunohistochemistry and in-situ hybridization.
  • The commonest sites of involvement included nasal cavity and adjoining tissue (85.5%).
  • Histologically, EN-NK/TCL was composed of small to medium-sized lymphoid cells.
  • Angiocentric and angiodestructive growth patterns, coagulative tumor necrosis and apoptotic bodies were frequently observed.
  • Immunohistochemical study showed that CD20, the B-cell marker, was negative in all cases.
  • The positivity rates for T-cell markers CD3epsilon, CD4, CD5 and CD8 were 100% (49/49), 7% (3/46), 8% (4/48) and 63% (29/46), respectively.
  • Most cases were also positive for NK-cell marker CD56 (79% 42/53).
  • There was a significant positive correlation between the bcl-2 positive expression and a high Ki-67 expression level.
  • CONCLUSIONS: EN-NK/TCL is a mature T-cell and NK-cell neoplasm which can be accurately diagnosed by histologic examination, immunohistochemical study and in-situ hybridization.
  • [MeSH-major] Antigens, CD3 / metabolism. Epstein-Barr Virus Infections. Herpesvirus 4, Human. Lymphoma, Extranodal NK-T-Cell. Nose Neoplasms

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  • (PMID = 19575894.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD3; 0 / Antigens, CD56; 0 / CD3E protein, human; 0 / Ki-67 Antigen; 0 / Poly(A)-Binding Proteins; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / RNA, Viral; 0 / TIA1 protein, human; EC 3.4.21.- / Granzymes
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49. Hamaguchi R, Saito H, Kegasawa K, Nakagawa A, Ryujin Y, Kurata K, Sugimoto H, Kobayashi A, Yamazaki K, Jin Y, Yoshimura N: [A case of extranodal NK/T-cell lymphoma, nasal type, with skin ulceration and multiple nodules in the lung]. Nihon Kokyuki Gakkai Zasshi; 2009 Jul;47(7):614-9

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  • [Title] [A case of extranodal NK/T-cell lymphoma, nasal type, with skin ulceration and multiple nodules in the lung].
  • We report a rare case of extranodal NK/T-cell lymphoma, nasal type, with skin ulceration and multiple nodules in the lung, and will compare this case with others in the literature.
  • Pathological and immunohistological findings suggested a diagnosis of extranodal NK/T-cell lymphoma, nasal type (WHO classification), stage IVB.
  • [MeSH-major] Lymphoma, Extranodal NK-T-Cell / pathology. Multiple Pulmonary Nodules / pathology. Skin Ulcer / pathology

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  • (PMID = 19637804.001).
  • [ISSN] 1343-3490
  • [Journal-full-title] Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
  • [ISO-abbreviation] Nihon Kokyuki Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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50. Suzuki R: Treatment of advanced extranodal NK/T cell lymphoma, nasal-type and aggressive NK-cell leukemia. Int J Hematol; 2010 Dec;92(5):697-701
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  • [Title] Treatment of advanced extranodal NK/T cell lymphoma, nasal-type and aggressive NK-cell leukemia.
  • Extranodal NK/T cell lymphoma, nasal type (ENKL) with advanced stage and aggressive NK-cell leukemia (ANKL) are highly aggressive neoplasms with a dismal clinical outcome.
  • This is a major reason for the refractoriness to conventional chemotherapeutic regimens for malignant lymphoma containing anthracycline.
  • ANKL needs another treatment strategy because of a systemic disease progression and extensive organ insufficiency.
  • Optimal treatment scheme using such effective agents for these unfavorable NK-cell tumors should further be explored.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Killer Cells, Natural / pathology. Leukemia, T-Cell / therapy. Lymphoma, Extranodal NK-T-Cell / drug therapy

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  • (PMID = 21116747.001).
  • [ISSN] 1865-3774
  • [Journal-full-title] International journal of hematology
  • [ISO-abbreviation] Int. J. Hematol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 6PLQ3CP4P3 / Etoposide; 7S5I7G3JQL / Dexamethasone; EC 3.5.1.1 / Asparaginase; UM20QQM95Y / Ifosfamide; YL5FZ2Y5U1 / Methotrexate
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51. Wakabayashi S, Arai A, Oshikawa G, Araki A, Watanabe M, Uchida N, Taniguchi S, Miura O: Extranodal NK/T cell lymphoma, nasal type, of the small intestine diagnosed by double-balloon endoscopy. Int J Hematol; 2009 Dec;90(5):605-10

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  • [Title] Extranodal NK/T cell lymphoma, nasal type, of the small intestine diagnosed by double-balloon endoscopy.
  • Extranodal NK/T-cell lymphoma (ENKL), nasal type, is rare and the small intestine is quite extraordinary as a primary lesion site.
  • He was referred to our hospital because of bloody stool and the diagnosis was made by double-balloon endoscopy (DBE) of the small intestine without surgical procedure.
  • Although he remained in CR for about 8 months after BMT, he died of disease recurrence 14 months after the diagnosis was made.
  • We describe the usefulness of DBE for diagnosis and management for ENKL of the small intestine.
  • [MeSH-major] Endoscopy, Gastrointestinal / methods. Intestinal Neoplasms / diagnosis. Lymphoma, Extranodal NK-T-Cell / diagnosis

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  • (PMID = 19936878.001).
  • [ISSN] 1865-3774
  • [Journal-full-title] International journal of hematology
  • [ISO-abbreviation] Int. J. Hematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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52. Yong W, Zheng W, Zhu J, Zhang Y, Wang X, Xie Y, Lin N, Xu B, Lu A, Li J: L-asparaginase in the treatment of refractory and relapsed extranodal NK/T-cell lymphoma, nasal type. Ann Hematol; 2009 Jul;88(7):647-52
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  • [Title] L-asparaginase in the treatment of refractory and relapsed extranodal NK/T-cell lymphoma, nasal type.
  • There is no standard salvage regimen for patients with refractory and relapsed extranodal NK/T-cell lymphoma (NKTCL), nasal type.
  • This study was conduced to evaluate the efficacy of L-asparaginase-based regimen as a salvage regimen, on refractory and relapsed extranodal NKTCL, nasal type.
  • Between March 1996 and March 2008, 45 patients with refractory and relapsed extranodal NKTCL, nasal type, were studied retrospectively.
  • L-Asparaginase-based regimen was obviously effective for the patients with refractory and relapsed extranodal NKTCL, nasal type.
  • [MeSH-major] Asparaginase / therapeutic use. Lymphoma, Extranodal NK-T-Cell / drug therapy. Nose Neoplasms / drug therapy. Salvage Therapy / methods

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  • (PMID = 19107482.001).
  • [ISSN] 1432-0584
  • [Journal-full-title] Annals of hematology
  • [ISO-abbreviation] Ann. Hematol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents; EC 3.5.1.1 / Asparaginase
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53. Yamaguchi M, Suzuki R, Kwong YL, Kim WS, Hasegawa Y, Izutsu K, Suzumiya J, Okamura T, Nakamura S, Kawa K, Oshimi K: Phase I study of dexamethasone, methotrexate, ifosfamide, L-asparaginase, and etoposide (SMILE) chemotherapy for advanced-stage, relapsed or refractory extranodal natural killer (NK)/T-cell lymphoma and leukemia. Cancer Sci; 2008 May;99(5):1016-20
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  • [Title] Phase I study of dexamethasone, methotrexate, ifosfamide, L-asparaginase, and etoposide (SMILE) chemotherapy for advanced-stage, relapsed or refractory extranodal natural killer (NK)/T-cell lymphoma and leukemia.
  • Extranodal natural killer (NK)/T-cell lymphoma, nasal type, and aggressive NK-cell leukemia are rare, and their standard therapy has not been established.
  • To develop an efficacious chemotherapeutic regimen, we conducted a dose-escalation feasibility study of a new chemotherapeutic regimen, SMILE, comprising the steroid dexamethasone, methotrexate, ifosfamide, L-asparaginase, and etoposide.
  • At level 1, six patients with extranodal NK/T-cell lymphoma, nasal type, were enrolled.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Leukemia, Lymphoid / drug therapy. Lymphoma, Extranodal NK-T-Cell / drug therapy

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  • (PMID = 18294294.001).
  • [ISSN] 1349-7006
  • [Journal-full-title] Cancer science
  • [ISO-abbreviation] Cancer Sci.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase I; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 6PLQ3CP4P3 / Etoposide; 7S5I7G3JQL / Dexamethasone; EC 3.5.1.1 / Asparaginase; UM20QQM95Y / Ifosfamide; YL5FZ2Y5U1 / Methotrexate
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54. Kato T, Tanabe J, Kanemoto M, Kobayashi C, Morita S, Karahashi T: A case of extranodal NK/T-cell lymphoma, nasal type mimicking typical manifestations of adult-onset Still's disease (AOSD) with hemophagocytic syndrome: diagnostic consideration between malignant lymphoma without lymphadenopathy and AOSD. Mod Rheumatol; 2009;19(6):675-80
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  • [Title] A case of extranodal NK/T-cell lymphoma, nasal type mimicking typical manifestations of adult-onset Still's disease (AOSD) with hemophagocytic syndrome: diagnostic consideration between malignant lymphoma without lymphadenopathy and AOSD.
  • Therefore, the possibility of malignant lymphoma was considered to be extremely low.
  • Leukocytopenia (2.4 x 10(3)/mul) was observed, and thus a diagnosis of adult-onset Still's disease (AOSD) with hemophagocytic syndrome (HPS) was made.
  • Bone marrow aspiration revealed the presence of lymphoma cells and hemophagocytosis, and the CD45 gating analysis showed expanding population of CD2(+), CD3(-), and CD56(+) cells.
  • Further, mucosal ulceration in the nasal cavity was detected.
  • Therefore, a diagnosis of extranodal natural killer (NK)/T-cell lymphoma, nasal type, concomitant with HPS was made, and treatment with dexamethasone, etoposide, ifosfamide, carboplatin (DeVIC) regimen ameliorated his symptoms and platelet transfusion dependency.
  • Later, a high titer of serum EBV-DNA was detected, which supported the diagnosis.
  • Diagnosing AOSD, extranodal presentation of malignant lymphoma such as extranodal NK/T-cell lymphoma, nasal type, should be carefully considered.

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  • (PMID = 19609486.001).
  • [ISSN] 1439-7609
  • [Journal-full-title] Modern rheumatology
  • [ISO-abbreviation] Mod Rheumatol
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 6PLQ3CP4P3 / Etoposide; 7S5I7G3JQL / Dexamethasone; BG3F62OND5 / Carboplatin; UM20QQM95Y / Ifosfamide
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55. Romero-Guadarrama MB, Aguilar-Martínez E: Extranodal nasal NK/T-cell lymphoma with dissemination to the central nervous system: a case report. Acta Cytol; 2010 Sep-Oct;54(5 Suppl):993-7
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  • [Title] Extranodal nasal NK/T-cell lymphoma with dissemination to the central nervous system: a case report.
  • BACKGROUND: Lymphomas that infiltrate the nervous system in children correspond to those of precursor B cells, such as lymphoblastic and Burkitt's lymphoma.
  • In adults, infiltration occurs in mature B-cell lymphomas, such as mantle cell lymphoma, and, rarely, in Hodgkin's lymphoma or peripheral NK/T-cell lymphomas.
  • CASE: We report the case of a 48-year-old man, who two years before death was diagnosed with extranodal nasal NK/T-cell lymphoma nasal in the left nostril.
  • He received radiotherapy and a year later presented tumor activity.
  • Infiltration to the central nervous system was revealed by computed axial tomography, and cytologic study of cerebrospinal fluid revealed malignant lymphoid cells; he then received intrathecal chemotherapy.
  • CONCLUSION: In Mexico, extranodal nasal NK/T-cell lymphoma occurs frequently.
  • [MeSH-major] Central Nervous System / pathology. Lymphoma, Extranodal NK-T-Cell / pathology. Nose Neoplasms / pathology
  • [MeSH-minor] Antigens, CD3 / metabolism. Bone Marrow Cells / pathology. Cell Nucleus / pathology. Cerebrospinal Fluid / cytology. Fatal Outcome. Humans. Male. Middle Aged. Nasal Cavity / pathology. Vacuoles / pathology

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  • (PMID = 21053585.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD3
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56. Ma X, Guo Y, Pang Z, Wang B, Lu H, Gu YJ, Guo X: A randomized phase II study of CEOP with or without semustine as induction chemotherapy in patients with stage IE/IIE extranodal NK/T-cell lymphoma, nasal type in the upper aerodigestive tract. Radiother Oncol; 2009 Dec;93(3):492-7
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  • [Title] A randomized phase II study of CEOP with or without semustine as induction chemotherapy in patients with stage IE/IIE extranodal NK/T-cell lymphoma, nasal type in the upper aerodigestive tract.
  • PURPOSE: In this randomized phase II study, we evaluated the efficacy of semustine added to CEOP regimen as induction chemotherapy in patients with stage I(E)/II(E) extranodal NK/T-cell lymphoma, nasal type in the upper aerodigestive tract.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Lymphoma, Extranodal NK-T-Cell / drug therapy. Nose Neoplasms / drug therapy. Semustine / administration & dosage

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  • (PMID = 19782419.001).
  • [ISSN] 1879-0887
  • [Journal-full-title] Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
  • [ISO-abbreviation] Radiother Oncol
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial
  • [Publication-country] Ireland
  • [Chemical-registry-number] 13909-09-6 / Semustine; 3Z8479ZZ5X / Epirubicin; 5J49Q6B70F / Vincristine; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CEOP protocol 1
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57. Kim J, Kim EY, Lee SK, Kim DI, Kim CH, Kim SH, Choi EC: Extranodal nasal-type NK/T-cell lymphoma: computed tomography findings of head and neck involvement. Acta Radiol; 2010 Mar;51(2):164-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extranodal nasal-type NK/T-cell lymphoma: computed tomography findings of head and neck involvement.
  • BACKGROUND: Extranodal nasal-type natural killer (NK)/T-cell lymphoma (NKTL) is a rare, but distinct clinical entity in Asian populations.
  • PURPOSE: To investigate the computed tomography (CT) findings in patients with extranodal nasal-type NKTL involving the head and neck.
  • MATERIAL AND METHODS: Twenty-nine patients (18 male, 11 female; mean age 51.5 years) with pathologically proven extranodal nasal-type NKTL were enrolled in this study.
  • Two head-and-neck radiologists retrospectively evaluated the CT scans with special attention to the primary site, the extent of involvement, and patterns of the lesions (i.e., morphologic features, ulceration or necrosis, and bone destruction).
  • RESULTS: The cases of nasal-type NKTL consisted of primary tumors arising from the sinonasal cavity in 13 patients (45%), the naso/oropharynx in three patients (10%), and simultaneous involvement in the nasal cavity and naso/oropharynx in 13 patients (45%).
  • Of the 26 patients with involvement of the nasal cavity, 18 (69%) presented with an infiltrative pattern, seven (27%) with a polypoid pattern, and one (4%) with a combined pattern.
  • CONCLUSION: Extranodal NKTL may be initially suggested by CT findings in the head and neck.
  • Clinicians should consider these findings indicative of the possibility of NKTL, and should perform a histopathologic confirmation to establish a diagnosis.
  • [MeSH-major] Head and Neck Neoplasms / radiography. Lymphoma, Extranodal NK-T-Cell / radiography. Nose Neoplasms / radiography. Tomography, X-Ray Computed / methods

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  • (PMID = 20092373.001).
  • [ISSN] 1600-0455
  • [Journal-full-title] Acta radiologica (Stockholm, Sweden : 1987)
  • [ISO-abbreviation] Acta Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Contrast Media; 4419T9MX03 / Iohexol; 712BAC33MZ / iopromide
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58. Chang BH, Stork L, Fan G: A unique case of adolescent CD56-negative extranodal NK/T-cell lymphoma, nasal type. Pediatr Dev Pathol; 2008 Jan-Feb;11(1):50-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A unique case of adolescent CD56-negative extranodal NK/T-cell lymphoma, nasal type.
  • Mature T-cell neoplasms are unusual in the pediatric population.
  • The majority of these neoplasms in the United States are anaplastic large cell lymphomas (ALCL) characterized by CD30 and anaplastic lymphoma kinase-1 expression.
  • Extranodal natural killer/T (NK/T)-cell lymphomas, nasal type, are extremely rare.
  • Extranodal NK/T-cell lymphomas often express CD56, are associated with Epstein-Barr virus, and are negative for CD30.
  • Clinically, extranodal NK/T-cell lymphomas are much more aggressive than ALCL, and require different treatment strategies.
  • The authors present an adolescent male with a CD56 negative extranodal NK/T-cell lymphoma, nasal type.
  • The lymphoma was partially positive for CD30, diffusely positive for EBV by in situ hybridization, and clonal for T-cell receptor gene rearrangement and cytogenetic abnormalities.
  • This case highlights the importance and difficulty of accurate identification of this type of rare tumor.
  • We further present the literature review and discuss the diagnostic criteria for extranodal NK/T lymphoma using morphologic, immunologic, molecular, and cytogenetic information.
  • [MeSH-major] Antigens, CD56 / metabolism. Lymphoma, Extranodal NK-T-Cell / diagnosis. Lymphoma, Large-Cell, Anaplastic / diagnosis
  • [MeSH-minor] Adolescent. Antigens, CD30 / metabolism. Chromosome Aberrations. Diagnosis, Differential. Gene Rearrangement. Herpesvirus 4, Human / isolation & purification. Humans. In Situ Hybridization. Male. Nose / pathology. Receptors, Antigen, T-Cell / genetics

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  • [CommentIn] Pediatr Dev Pathol. 2008 Jul-Aug;11(4):325; author reply 326 [18839448.001]
  • (PMID = 18237230.001).
  • [ISSN] 1093-5266
  • [Journal-full-title] Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
  • [ISO-abbreviation] Pediatr. Dev. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD30; 0 / Antigens, CD56; 0 / Receptors, Antigen, T-Cell
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59. Kim TM, Lee SY, Jeon YK, Ryoo BY, Cho GJ, Hong YS, Kim HJ, Kim SY, Kim CS, Kim S, Kim JS, Sohn SK, Song HH, Lee JL, Kang YK, Yim CY, Lee WS, Yuh YJ, Kim CW, Heo DS, Lymphoma Subcommittee of the Korean Cancer Study Group: Clinical heterogeneity of extranodal NK/T-cell lymphoma, nasal type: a national survey of the Korean Cancer Study Group. Ann Oncol; 2008 Aug;19(8):1477-84
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  • [Title] Clinical heterogeneity of extranodal NK/T-cell lymphoma, nasal type: a national survey of the Korean Cancer Study Group.
  • BACKGROUND: This national survey was undertaken to propose the classification of extranodal natural killer (NK)/T-cell lymphoma (NTCL) subtypes and to clarify a clinical heterogeneity.
  • In the NUAT subset, extranodal sites and regional nodes predicted the OS, while Ann Arbor staging, age, performance status, and lactate dehydrogenase level predicted the OS in the UAT subset.

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  • (PMID = 18385201.001).
  • [ISSN] 1569-8041
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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60. Bossard C, Belhadj K, Reyes F, Martin-Garcia N, Berger F, Kummer JA, Brière J, Baglin AC, Cheze S, Bosq J, Ribrag V, Gisselbrecht C, Mounier N, Gaulard P: Expression of the granzyme B inhibitor PI9 predicts outcome in nasal NK/T-cell lymphoma: results of a Western series of 48 patients treated with first-line polychemotherapy within the Groupe d'Etude des Lymphomes de l'Adulte (GELA) trials. Blood; 2007 Mar 1;109(5):2183-9

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  • [Title] Expression of the granzyme B inhibitor PI9 predicts outcome in nasal NK/T-cell lymphoma: results of a Western series of 48 patients treated with first-line polychemotherapy within the Groupe d'Etude des Lymphomes de l'Adulte (GELA) trials.
  • Nasal NK/T-cell lymphoma is a rare disease entity with a poor outcome.
  • Forty-eight patients with nasal T/NK-cell lymphoma who received first-line polychemotherapy (n = 44) or chemoradiotherapy (n = 4) were analyzed for expression of active caspase-3 (aC3), granzyme B protease inhibitor 9 (PI9), and Bcl-2 proteins.
  • Lymphomas were CD3+/CD5-/granzyme B+ and EBV-associated.
  • In view of its constitutive expression by normal NK cells, it is suggested that loss of PI9 expression in tumor cells may reflect some mechanism associated with progression.
  • [MeSH-major] Granzymes / antagonists & inhibitors. Killer Cells, Natural / enzymology. Lymphoma, T-Cell / drug therapy. Lymphoma, T-Cell / metabolism. Serpins / metabolism. T-Lymphocytes / enzymology

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  • (PMID = 17077322.001).
  • [ISSN] 0006-4971
  • [Journal-full-title] Blood
  • [ISO-abbreviation] Blood
  • [Language] eng
  • [Publication-type] Controlled Clinical Trial; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / SERPINB9 protein, human; 0 / Serpins; EC 3.4.21.- / Granzymes
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61. Barrionuevo C, Zaharia M, Martinez MT, Taxa L, Misad O, Moscol A, Sarria G, Guerrero I, Casanova L, Flores C, Zevallos-Giampietri EA: Extranodal NK/T-cell lymphoma, nasal type: study of clinicopathologic and prognosis factors in a series of 78 cases from Peru. Appl Immunohistochem Mol Morphol; 2007 Mar;15(1):38-44
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  • [Title] Extranodal NK/T-cell lymphoma, nasal type: study of clinicopathologic and prognosis factors in a series of 78 cases from Peru.
  • It is well known that extranodal NK/T-cell lymphoma (NK/TCL) nasal type clusters in Asian countries.
  • A large series of 78 cases of nasal NK/TCL from Peru is analyzed in the present study.
  • Except for nasal obstruction, more common in group 2, all other symptoms were similar in both groups.
  • In this series type-2 EBV was found more frequent than type-1 EBV, contrarily to that observed in Asian series.
  • The present study has shown that dividing nasal NK/TCL in monomorphic and polymorphic variants, according to frequency of large cells, does not correlate with clinical and prognostic factors.

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  • (PMID = 17536305.001).
  • [ISSN] 1541-2016
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
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62. Wang J, Geng SA, Su Z, Xu J, Xu S, Wang F, Mo X, Feng Z: Rearranged T-cell receptor gene and positive Epstein-Barr virus-encoded nuclear RNA in an extranodal NK/T-cell lymphoma with cutaneous manifestation only: case study. Clin Exp Dermatol; 2007 Nov;32(6):744-8
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  • [Title] Rearranged T-cell receptor gene and positive Epstein-Barr virus-encoded nuclear RNA in an extranodal NK/T-cell lymphoma with cutaneous manifestation only: case study.
  • Natural killer (NK)/cytotoxic T-cell lymphoma, a new type of cutaneous neoplasm, has been described recently in the World Health Organization/European Organization for Research and Treatment of Cancer classification for cutaneous lymphomas.
  • Routine clinical and laboratory examinations found no primary nasal involvement.
  • Biopsies taken from nasal mucosa and skin showed that the tumour only involved dermis and subcutaneous tissue, and the infiltrated lymphohistiocytic tumour cells were CD56+, TIA+, CD45RO+ and CD30+.
  • Clonal T-cell receptor-gamma2 gene rearrangement was positive.
  • A diagnosis of extranodal NK/T-cell lymphoma, nasal type, was made.
  • [MeSH-major] Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor. Lymphoma, Extranodal NK-T-Cell / pathology. Lymphoma, T-Cell, Cutaneous / pathology. RNA-Binding Proteins / analysis. Ribosomal Proteins / analysis. Skin Neoplasms / pathology

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  • (PMID = 17953643.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / RNA-Binding Proteins; 0 / Ribosomal Proteins; 135844-68-7 / RPL22 protein, human
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63. Sitthinamsuwan P, Pongpruttipan T, Chularojmontri L, Pattanaprichakul P, Khuhapinant A, Sukpanichnant S: Extranodal NK/T cell lymphoma, nasal type, presenting with primary cutaneous lesion mimicking granulomatous panniculitis: a case report and review of literature. J Med Assoc Thai; 2010 Aug;93(8):1001-7
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  • [Title] Extranodal NK/T cell lymphoma, nasal type, presenting with primary cutaneous lesion mimicking granulomatous panniculitis: a case report and review of literature.
  • BACKGROUND: Cutaneous extranodal NK/T-cell lymphoma, nasal type (NK/T) is relatively rare, associated with aggressive behavior and poor prognosis.
  • Histopathological findings, immunohistochemical study and EBV-encoded RNA (EBER) in situ hybridization are essential for the diagnosis.
  • CASE REPORT: A 54-year-old Thai man with NK/T of the nasal cavity initially presented with cutaneous NK/T mimicking granulomatous panniculitis.
  • CONCLUSION: Cutaneous NK/T can produce granulomatous panniculitis.
  • The recognition of atypical lymphoid cells showing angiocentricity together with immunohistochemistry and EBER in situ hybridization are crucial for the correct diagnosis.
  • [MeSH-major] Lymphoma, Extranodal NK-T-Cell / pathology. Nasal Cavity / pathology. Nose Neoplasms / pathology. Panniculitis / pathology
  • [MeSH-minor] Biopsy. Diagnosis, Differential. Fatal Outcome. Humans. Immunohistochemistry. Lymphoma, T-Cell, Cutaneous / pathology. Male. Middle Aged. Skin Neoplasms / pathology

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  • (PMID = 20718178.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Thailand
  • [Number-of-references] 25
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64. Kim TM, Park YH, Lee SY, Kim JH, Kim DW, Im SA, Kim TY, Kim CW, Heo DS, Bang YJ, Chang KH, Kim NK: Local tumor invasiveness is more predictive of survival than International Prognostic Index in stage I(E)/II(E) extranodal NK/T-cell lymphoma, nasal type. Blood; 2005 Dec 1;106(12):3785-90
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  • [Title] Local tumor invasiveness is more predictive of survival than International Prognostic Index in stage I(E)/II(E) extranodal NK/T-cell lymphoma, nasal type.
  • This study was launched to determine the prognostic significance of local tumor invasiveness (LTI) in 114 patients diagnosed with stage I(E)/II(E) extranodal natural killer (NK)/T-cell lymphoma, nasal type (NTCL).
  • LTI is the most important prognostic factor in predicting low probability of CR and reduced OS and DFS in nasal stage I(E)/II(E) NTCL.
  • [MeSH-major] Lymphoma, T-Cell / mortality. Neoplasm Invasiveness. Neoplasm Staging. Nose Neoplasms / mortality
  • [MeSH-minor] Adolescent. Adult. Age Factors. Aged. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Disease-Free Survival. Female. Humans. Killer Cells, Natural / pathology. Male. Middle Aged. Prognosis. Radiotherapy. Remission Induction. Survival Analysis. Survival Rate

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  • (PMID = 16109779.001).
  • [ISSN] 0006-4971
  • [Journal-full-title] Blood
  • [ISO-abbreviation] Blood
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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65. Kim SJ, Kim K, Kim BS, Kim CY, Suh C, Huh J, Lee SW, Kim JS, Cho J, Lee GW, Kang KM, Eom HS, Pyo HR, Ahn YC, Ko YH, Kim WS: Phase II trial of concurrent radiation and weekly cisplatin followed by VIPD chemotherapy in newly diagnosed, stage IE to IIE, nasal, extranodal NK/T-Cell Lymphoma: Consortium for Improving Survival of Lymphoma study. J Clin Oncol; 2009 Dec 10;27(35):6027-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Phase II trial of concurrent radiation and weekly cisplatin followed by VIPD chemotherapy in newly diagnosed, stage IE to IIE, nasal, extranodal NK/T-Cell Lymphoma: Consortium for Improving Survival of Lymphoma study.
  • PURPOSE: On the basis of the benefits of frontline radiation in early-stage, extranodal, natural killer (NK)/T-cell lymphoma (ENKTL), we conducted a phase II trial of concurrent chemoradiotherapy (CCRT) followed by three cycles of etoposide, ifosfamide, cisplatin, and dexamethasone (VIPD).
  • PATIENTS AND METHODS: Thirty patients with newly diagnosed, stages IE to IIE, nasal ENKTL received CCRT (ie radiation 40 to 52.8 Gy and cisplatin 30 mg/m(2) weekly).
  • CONCLUSION: Patients with newly diagnosed, stages IE to IIE, nasal ENKTL are best treated with frontline CCRT.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Lymphoma, Extranodal NK-T-Cell / drug therapy. Lymphoma, Extranodal NK-T-Cell / radiotherapy. Nose Neoplasms / drug therapy. Nose Neoplasms / radiotherapy

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  • [CommentIn] J Clin Oncol. 2010 May 10;28(14):e229; author reply e230 [20351319.001]
  • (PMID = 19884539.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 6PLQ3CP4P3 / Etoposide; 7S5I7G3JQL / Dexamethasone; Q20Q21Q62J / Cisplatin; UM20QQM95Y / Ifosfamide
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66. Yasuda H, Sugimoto K, Imai H, Isobe Y, Sasaki M, Kojima Y, Nakamura S, Oshimi K: Expression levels of apoptosis-related proteins and Ki-67 in nasal NK / T-cell lymphoma. Eur J Haematol; 2009 Jan;82(1):39-45
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  • [Title] Expression levels of apoptosis-related proteins and Ki-67 in nasal NK / T-cell lymphoma.
  • OBJECTIVES: Nasal natural killer (NK)/T-cell lymphoma is characterized by chemo-resistance, angiodestruction, and aggressive tumor progression.
  • METHODS: Expression levels of major apoptosis-related proteins Bcl-2, Bcl-x, Mcl-1, Bax, and a proliferative marker Ki-67 were analyzed in 11 nasal NK/T-cell lymphoma cases by immunohistochemical methods.
  • Nine cases were of NK-cell lineage and two cases were of T-cell lineage.
  • For comparison, 12 follicular lymphoma (FL) cases and 16 diffuse large B-cell lymphoma (DLBCL) cases were also studied.
  • RESULTS AND CONCLUSIONS: Bax expression was low in all nasal NK-cell lymphoma cases, which constitute the major population of nasal NK/T-cell lymphoma.
  • Bax expression in nasal NK-cell lymphoma was similar to FL and significantly lower compared with DLBCL.
  • Bcl-2 expression was significantly lower in nasal NK/T-cell lymphoma compared with that of FL and DLBCL.
  • Bcl-x expression was high in all three lymphomas.
  • Two distinct Mcl-1 expression groups existed for nasal NK/T-cell lymphoma (6.2 +/- 5.2% and 59.1 +/- 12.3%, 95% CI).
  • Ki-67 expression was high in nasal NK/T-cell lymphoma, and worse prognostic groups tended to express higher levels of Ki-67.
  • The results suggest a combination of impaired apoptosis and aggressive proliferation in nasal NK/T-cell lymphoma, and may provide explanations for its poor prognosis.
  • [MeSH-major] Apoptosis Regulatory Proteins / metabolism. Ki-67 Antigen / metabolism. Lymphoma, Extranodal NK-T-Cell / metabolism. Nose Neoplasms / metabolism

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  • (PMID = 18778369.001).
  • [ISSN] 1600-0609
  • [Journal-full-title] European journal of haematology
  • [ISO-abbreviation] Eur. J. Haematol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Apoptosis Regulatory Proteins; 0 / Ki-67 Antigen
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67. D'Souza GA, Sunad R, Rajagopalan N, Ananthamurthy A, Murthy KR, Babu K: NK/T-cell lymphoma in AIDS. J Assoc Physicians India; 2006 Nov;54:890-2
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  • [Title] NK/T-cell lymphoma in AIDS.
  • Further workup showed the mass to be an NK/T cell lymphoma.
  • [MeSH-major] HIV Infections / complications. Lymphoma, AIDS-Related / diagnosis. Lymphoma, T-Cell / diagnosis. Nose Neoplasms / diagnosis
  • [MeSH-minor] Adult. Antiretroviral Therapy, Highly Active. Blindness / etiology. Humans. Killer Cells, Natural. Male

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  • (PMID = 17249261.001).
  • [ISSN] 0004-5772
  • [Journal-full-title] The Journal of the Association of Physicians of India
  • [ISO-abbreviation] J Assoc Physicians India
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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68. Zhang Z, Shi Q, An X, Ma H, Zhou H, Ma J, Zhou X: NK/T-cell lymphoma in a child with hypersensitivity to mosquito bites. J Pediatr Hematol Oncol; 2009 Nov;31(11):855-7
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  • [Title] NK/T-cell lymphoma in a child with hypersensitivity to mosquito bites.
  • However, some kind of malignant tumor is closely associated with HMB, especially natural killer (NK)/T-cell lymphoma.
  • We described a nasal-type NK/T-cell lymphoma in a 9-year-old girl after a history of 2 years earlier of HMB.
  • Pathologic evaluation revealed the typical histologic features of NK/T-cell lymphoma, and the dermal and subcutaneous inflammatory reaction of HMB lesions.
  • HMB is rarely reported and should be kept in mind as a clinical sign of subsequent NK/T-cell lymphoma in Asian country where HMB is relatively frequently encountered.
  • [MeSH-major] Culicidae. Hypersensitivity / pathology. Insect Bites and Stings / pathology. Lymphoma, Extranodal NK-T-Cell / pathology. Nose Neoplasms / pathology

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  • (PMID = 19636274.001).
  • [ISSN] 1536-3678
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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69. Meslemani DM, Jones L: An unusual presentation of nasal type NK/T-cell lymphoma of the nose. Laryngoscope; 2010;120 Suppl 4:S167
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  • [Title] An unusual presentation of nasal type NK/T-cell lymphoma of the nose.
  • OBJECTIVES: Case report of a male with a rare nasal type NK/T cell lymphoma that presented as an aggressive nasal infection superimposed with squamous and basal cell carcinoma.
  • A review of the diagnosis, management, and prognosis nasal type NK/T cell lymphoma will be presented.
  • METHODS: Review of the literature for cases of nasal type NK/T cell lymphoma, with particular attention to its presentations.
  • RESULTS: Differential diagnosis includes aggressive infection of the nasal skin, carcinoma, and lymphoma.
  • CONCLUSION: No cases in the literature of NK/T cell lymphoma have been reported that presented with an aggressive infection with initial biopsies that revealed squamous cell and basal cell carcinoma, which led to surgical management and a definitive diagnosis of Nasal type NK/T cell lymphoma.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Carcinoma, Squamous Cell / pathology. Lymphoma, T-Cell, Cutaneous / pathology. Nose Neoplasms / pathology
  • [MeSH-minor] Combined Modality Therapy. Diagnosis, Differential. Humans. Male. Middle Aged. Rhinitis / pathology. Sinusitis / pathology

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  • (PMID = 21225765.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
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70. Guo HQ, Pu XX, Guo CC, Rao HL, Li HR, Lin TY: The role of Skp2 in extranodal NK/T-cell lymphoma. Chin J Cancer; 2010 May;29(5):567-71

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  • [Title] The role of Skp2 in extranodal NK/T-cell lymphoma.
  • However, there was no intensive study on the relationship between Skp2 and extranodal NK/T cell lymphoma.
  • This study was to explore the role of Skp2 in extranodal NK/T cell lymphoma.
  • METHODS: The clinicopathological data of 39 patients with extranodal NK/T cell lymphoma were analyzed.
  • Multivariate analysis showed that Skp2 expression (P <0.001), LDH (P = 0.026) and ECOG PS (P = 0.003) were dependent prognostic factors of extranodal NK/T cell lymphoma.
  • CONCLUSION: High expression of Skp2 is an independent unfavorite adverse prognostic factor of extranodal NK/T cell lymphoma.
  • [MeSH-major] Lymphoma, Extranodal NK-T-Cell / metabolism. S-Phase Kinase-Associated Proteins / metabolism

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  • (PMID = 20426910.001).
  • [ISSN] 1000-467X
  • [Journal-full-title] Chinese journal of cancer
  • [ISO-abbreviation] Chin J Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / S-Phase Kinase-Associated Proteins; EC 1.1.1.27 / L-Lactate Dehydrogenase
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71. Jian D, Wu S, Chen D, Ying M, Yang B, You Z, Liu L, Ding Z: [Nasal NK/T cell lymphoma: a report of 11 cases]. Lin Chuang Er Bi Yan Hou Ke Za Zhi; 2005 Jul;19(14):638-9
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  • [Title] [Nasal NK/T cell lymphoma: a report of 11 cases].
  • OBJECTIVE: To investigate the clinical diagnosis consideration of nasal NK/T cell lymphoma.
  • METHOD: Reviewing the clinical data of 11 patients with nasal NK/T cell lymphoma between 1992 to 2003.
  • CONCLUSION: Nasal NK/T cell lymphoma is easily misdiagnosed.
  • The right diagnosis can be built with clinical, pathological and imaging examination.
  • [MeSH-major] Diagnostic Errors. Lymphoma, Extranodal NK-T-Cell. Nose Neoplasms

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  • (PMID = 16248460.001).
  • [Journal-full-title] Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
  • [ISO-abbreviation] Lin Chuang Er Bi Yan Hou Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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72. Wang BY, Hong XN, Yin JL, Lu HF, Li XQ, Ma XJ, Guo Y: [Prognostic predictors of nasal NK/T cell lymphoma detected by immunohistochemical staining]. Zhonghua Zhong Liu Za Zhi; 2006 Jul;28(7):523-5
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  • [Title] [Prognostic predictors of nasal NK/T cell lymphoma detected by immunohistochemical staining].
  • OBJECTIVE: To investigate the prognostic predictors of nasal NK/T cell lymphoma.
  • METHODS: The clinicopathologic feature data of 61 patients with nasal NK/T cell lymphoma proven by pathological examination from Jan.
  • RESULTS: In univariate analysis, performance status, LDH level, clinical stage, initial treatment response, CD56, Ki-67 and CD95 were found to be the prognostic factors associated with time to progression (TTP) in nasal NK/T cell lymphoma, while the performance status, B symptoms, LDH level, initial treatment response, Ki-67 and CD95 were demonstrated as prognostic factors related to overall survival.
  • [MeSH-major] Biomarkers, Tumor / analysis. Killer Cells, Natural / pathology. Lymphoma, T-Cell / pathology. Nose Neoplasms / pathology

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  • (PMID = 17147118.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD44; 0 / Antigens, CD95; 0 / BIRC5 protein, human; 0 / Biomarkers, Tumor; 0 / CD44 protein, human; 0 / Inhibitor of Apoptosis Proteins; 0 / Ki-67 Antigen; 0 / Microtubule-Associated Proteins; 0 / Neoplasm Proteins; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CHOP protocol
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73. Lan SK, Lin CW, Ho HC, Lee MS, Tzeng JE, Su YC: Penile metastasis secondary to nasal NK/T-cell lymphoma. Urology; 2008 Nov;72(5):1014-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Penile metastasis secondary to nasal NK/T-cell lymphoma.
  • We report on a case of recurrent nasal NK/T-cell lymphoma in a patient who presented with a penile mass.
  • Metastatic penile lymphoma is extremely rare.
  • [MeSH-major] Lymphoma, Extranodal NK-T-Cell / pathology. Lymphoma, Extranodal NK-T-Cell / ultrasonography. Penile Neoplasms / secondary. Penile Neoplasms / ultrasonography

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  • (PMID = 18639328.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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74. Xiao YL, Zhang DP, Wang Y: [Primary pulmonary involvement of NK/T-cell lymphoma: report of two cases with literature review]. Zhonghua Nei Ke Za Zhi; 2007 Dec;46(12):988-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Primary pulmonary involvement of NK/T-cell lymphoma: report of two cases with literature review].
  • OBJECTIVE: To describe the imaging, clinical and pathological features of primary pulmonary involvement of NK/T-cell lymphoma.
  • METHODS: The imaging, clinical and pathological features of 2 patients with primary pulmonary involvement of NK/T-cell lymphoma were retrospectively analyzed.
  • RESULTS: The 2 cases (both young women) of NK/T-cell lymphoma were confirmed with CT-guided percutaneous needle lung biopsy and the lung was the primary involved site.
  • CONCLUSION: The lungs may be the primary involved sites of NK/T-cell lymphoma and the prognosis is grim.
  • [MeSH-major] Lung Neoplasms / pathology. Lymphoma, Extranodal NK-T-Cell / pathology

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  • (PMID = 18478913.001).
  • [ISSN] 0578-1426
  • [Journal-full-title] Zhonghua nei ke za zhi
  • [ISO-abbreviation] Zhonghua Nei Ke Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD3; 0 / Antigens, CD56; 0 / DNA, Viral; EC 3.1.3.48 / Antigens, CD45
  • [Number-of-references] 12
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75. Lee BH, Kim SY, Kim MY, Hwang YJ, Han YH, Seo JW, Kim YH, Cha SJ, Hur G: CT of nasal-type T/NK cell lymphoma in the lung. J Thorac Imaging; 2006 Mar;21(1):37-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] CT of nasal-type T/NK cell lymphoma in the lung.
  • Nasal-type T-cell/natural killer cell lymphoma is a new distinctive clinicopathologic entity with a characteristic immunophenotypic expression of CD56.
  • Most cases show a predilection for the nasopharyngeal region and are referred to as nasal T/NK-cell lymphoma.
  • To the best of our knowledge, nasal type T/NK cell lymphoma with isolated lung involvement has not been reported.
  • [MeSH-major] Killer Cells, Natural / pathology. Lung / radiography. Lung Neoplasms / diagnosis. Lymphoma, T-Cell / diagnosis. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Adult. Biopsy, Needle / methods. Diagnosis, Differential. Dyspnea / etiology. Fatal Outcome. Female. Fever / etiology. Humans. Rare Diseases. Sweating / physiology

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  • (PMID = 16538154.001).
  • [ISSN] 0883-5993
  • [Journal-full-title] Journal of thoracic imaging
  • [ISO-abbreviation] J Thorac Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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76. Sandner A, Helmbold P, Winkler M, Gattenlöhner S, Müller-Hermelink HK, Holzhausen HJ: Cutaneous dissemination of nasal NK/T-cell lymphoma in a young girl. Clin Exp Dermatol; 2008 Aug;33(5):615-8
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  • [Title] Cutaneous dissemination of nasal NK/T-cell lymphoma in a young girl.
  • In Europe and the USA, the incidence of primary nasal natural killer (NK)/T-cell lymphoma is rare.
  • We describe the case of a 17-year-old white German girl with a primary nasal NK/T-cell lymphoma and cutaneous dissemination.
  • She presented with multiple maculopapular patches involving the trunk and thighs, and a 4-week history of headache, fever and fatigue.
  • Biopsies of the skin and the nasal mucosa were taken.
  • Pathological examination of both specimens revealed a NK/T-cell lymphoma.
  • Epstein-Barr virus RNA was detected in the lymphoma cells by in situ hybridization.
  • [MeSH-major] Epstein-Barr Virus Infections / pathology. Lymphoma, T-Cell / pathology. Lymphoma, T-Cell, Cutaneous / pathology. Nose Neoplasms / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adolescent. Diagnosis, Differential. Fatal Outcome. Female. Humans

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  • (PMID = 18616730.001).
  • [ISSN] 1365-2230
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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77. Nigidie A, Schneider J: Nasal NK/T-cell lymphoma causing diagnostic difficulties. Ethiop Med J; 2005 Jul;43(3):197-201
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  • [Title] Nasal NK/T-cell lymphoma causing diagnostic difficulties.
  • We present history, clinical presentation and anatomo-pathologic findings of a 24-year-old female patient with a nasal NK/T-cell lymphoma.
  • This rare tumor is characterized by its angiocentric and angiodestructive growth, which results in extensive tumor necrosis.
  • However, this necrosis is a key feature: it is the result of the capacity of neoplastic NK/T-cells to invade vessels.
  • The T-cell character of the neoplastic lymphoid has been shown by immunohistochemitry.
  • [MeSH-major] Granuloma, Lethal Midline / diagnosis. Killer Cells, Natural. Lymphoma, T-Cell / diagnosis. Nose / physiopathology. Nose Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Fatal Outcome. Female. Humans

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  • (PMID = 16370552.001).
  • [ISSN] 0014-1755
  • [Journal-full-title] Ethiopian medical journal
  • [ISO-abbreviation] Ethiop. Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Ethiopia
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78. Nagatani M, Ando R, Yamakawa S, Saito T, Tamura K: Histological and immunohistochemical studies on spontaneous rat astrocytomas and malignant reticulosis. Toxicol Pathol; 2009 Aug;37(5):599-605

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Histological and immunohistochemical studies on spontaneous rat astrocytomas and malignant reticulosis.
  • Among spontaneous neoplasms of the rat central nervous system, the discrimination between astrocytoma and malignant reticulosis (MR) is sometimes difficult because of their similar cell morphology and infiltration patterns.
  • These cases were diagnosed as benign/malignant astrocytoma containing no neoplastic oligodendroglial elements or MR according to the diagnostic criteria of the World Health Organization International Classification of Rodent Tumors (Mohr et al. 1994).
  • From the results of morphological and immunohistochemical examinations, it was indicated that there are no distinctive differences between spontaneous astrocytomas and MR in rats, and they are probably derived from the same cell lineage, that is, microglia, macrophage, or radial glia.

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  • (PMID = 19487256.001).
  • [ISSN] 1533-1601
  • [Journal-full-title] Toxicologic pathology
  • [ISO-abbreviation] Toxicol Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Nerve Tissue Proteins; 0 / Vimentin
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79. Kim JH, Lee JH, Lee J, Oh SO, Chang DK, Rhee PL, Kim JJ, Rhee JC, Lee J, Kim WS, Ko YH: Primary NK-/T-cell lymphoma of the gastrointestinal tract: clinical characteristics and endoscopic findings. Endoscopy; 2007 Feb;39(2):156-60

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  • [Title] Primary NK-/T-cell lymphoma of the gastrointestinal tract: clinical characteristics and endoscopic findings.
  • BACKGROUND AND STUDY AIMS: Primary NK-/T-cell lymphoma of the gastrointestinal tract is a very rare disease with a poor prognosis.
  • The aim of this study was to determine the clinical and endoscopic characteristics of patients with primary gastrointestinal NK-/T-cell lymphoma.
  • PATIENTS AND METHODS: The clinical features of 14 patients with primary gastrointestinal NK-/T-cell lymphoma and the endoscopic findings in 11 of these patients were reviewed.
  • Their median age was 42 years (range 23-78) at the time of diagnosis.
  • RESULTS: The initial presenting symptoms of primary gastrointestinal NK-/T-cell lymphoma were gastrointestinal bleeding (n = 6, 42%), abdominal pain (n = 4, 29%), and epigastric soreness (n = 4, 29%).
  • The disease was at an advanced stage at the time of diagnosis: stage II in 5 patients (36%); stage III in 4 (28%); and stage IV in 5 (36%).
  • CONCLUSIONS: Primary gastrointestinal NK-/T-cell lymphoma was endoscopically characterized by superficial/erosive, ulcerative, or ulceroinfiltrative lesions without fungating mass.
  • [MeSH-major] Endoscopy, Gastrointestinal. Gastrointestinal Neoplasms / pathology. Killer Cells, Natural / pathology. Lymphoma, T-Cell / pathology

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  • (PMID = 17657701.001).
  • [ISSN] 1438-8812
  • [Journal-full-title] Endoscopy
  • [ISO-abbreviation] Endoscopy
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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80. Mani R, Belcadhi M, Krifa N, Sriha B, Elomri H, Ben Ali M, Abdelkéfi M, Bouzouita K: [NK/T-Cell lymphoma of nasopharynx]. Ann Otolaryngol Chir Cervicofac; 2006 Sep;123(4):189-93
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  • [Title] [NK/T-Cell lymphoma of nasopharynx].
  • [Transliterated title] Lymphomes T/NK du nasopharynx.
  • OBJECTIVE: Discussion of the clinical and paraclinical features of a rare tumor in the nasopharynx, the NK/T-cell lymphoma, with an emphasis on the implications of Epstein Barr Virus (EBV) in its pathogenesis and prognosis.
  • CASES REPORT: We report the cases of a woman and a man aged 34 and 48, respectively.
  • Clinical presentation was non-specific and diagnosis was established with deep biopsies under general anesthesia.
  • CONCLUSION: Diagnosis of NK/T-cell lymphoma may be delayed in the event of non-specific symptoms.
  • [MeSH-major] Epstein-Barr Virus Infections / complications. Herpesvirus 4, Human / isolation & purification. Killer Cells, Natural. Lymphoma, T-Cell. Nasopharyngeal Neoplasms

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  • (PMID = 17088706.001).
  • [ISSN] 0003-438X
  • [Journal-full-title] Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Société d'oto-laryngologie des hôpitaux de Paris
  • [ISO-abbreviation] Ann Otolaryngol Chir Cervicofac
  • [Language] fre
  • [Publication-type] Case Reports; Comparative Study; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; 9PHQ9Y1OLM / Prednisolone; VAP-cyclo protocol
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81. Yue L, Cheng J, Zhang Pf, Lin G, Yi Z, Zhang R: [Expression and its significance of STAT3, STAT5, Survivin and Ki67 in nasal NK/T cell lymphoma]. Lin Chuang Er Bi Yan Hou Ke Za Zhi; 2006 Oct;20(20):931-3, 936
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Expression and its significance of STAT3, STAT5, Survivin and Ki67 in nasal NK/T cell lymphoma].
  • OBJECTIVE: To study the expression and its significance of STAT3, STAT5, Survivin and Ki67 in the Epstein-Barr virus associated nasal NK/T cell lymphoma.
  • METHOD: The expression of STAT3, STAT5, Survivin and Ki67 were detected with immunohistochemistry in 25 cases of nasal NK/T cell lymphoma, and their relationship was analyzed.
  • Nasal cavity tissues from 20 cases of chronic sinusitis were as the control group.
  • RESULT: The positive rates of STAT3 in the lymphoma and in control group were 56% and 10%, respectively (P <0.01).
  • The positive rates of STAT5 in the lymphoma and in control group were 68% and 15%, respectively (P <0.01).
  • The positive rates of Survivin and Ki67 of nasal NK/T cell-lymphoma were 68% and 72%, respectively; but it in the control group was 0% and 20%, respectively, P <0.01.
  • CONCLUSION: The pathway of STAT may play a role in the development of nasal NK/T cell lymphoma.
  • STAT maybe take part in the formation of nasal NK/T cell lymphoma through induction of Survivin and Ki67.
  • [MeSH-major] Ki-67 Antigen / metabolism. Lymphoma, Extranodal NK-T-Cell / metabolism. Microtubule-Associated Proteins / metabolism. Nose Neoplasms / metabolism. STAT3 Transcription Factor / metabolism. STAT5 Transcription Factor / metabolism

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  • (PMID = 17225522.001).
  • [Journal-full-title] Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
  • [ISO-abbreviation] Lin Chuang Er Bi Yan Hou Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / BIRC5 protein, human; 0 / Inhibitor of Apoptosis Proteins; 0 / Ki-67 Antigen; 0 / Microtubule-Associated Proteins; 0 / STAT3 Transcription Factor; 0 / STAT3 protein, human; 0 / STAT5 Transcription Factor; 0 / STAT5B protein, human
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82. Reinartz SM, Schot LJ, Riedl RG, Oldenburger F, van den Brekel MW: Presentation of two cases of nasal type NK/T-cell lymphoma. Eur Arch Otorhinolaryngol; 2007 Jan;264(1):39-43
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  • [Title] Presentation of two cases of nasal type NK/T-cell lymphoma.
  • Nasal type NK/T-cell lymphoma is a rare type of predominantly extranodal non-Hodgkin lymphoma.
  • Early and correct diagnosis with prompt treatment of NK/T-cell lymphoma is important in view of its potentially aggressive behavior and poor response to treatment with additional sites of tumor developing sometimes weeks or months after initial diagnosis.
  • Unfortunately diagnosis of NK/T-cell lymphomas often proves difficult.
  • The diagnosis is essentially based on the clinical presentation of extranodal ulcerative lesions in the upper aero-digestive tract and histopathologic analysis of biopsies using immunohistochemistry.
  • Here we present two cases with nasal-type NK/T-cell lymphoma that illustrate that definitive diagnosis is often delayed due to the atypical initial presentation.
  • We will discuss the pitfalls in diagnosing this rare type of neoplasm and review the treatment options.
  • [MeSH-major] Lymphoma, Extranodal NK-T-Cell / pathology. Nose Neoplasms / pathology

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  • (PMID = 17082942.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Anti-Inflammatory Agents
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83. Rajnics P, Krenács L, Kenéz A, Járay Z, Bagdi E, Demeter J: [Long-term survival after nasal NK/T cell lymphoma]. Orv Hetil; 2008 Apr 27;149(17):801-5
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  • [Title] [Long-term survival after nasal NK/T cell lymphoma].
  • [Transliterated title] Nazális NK/T-sejtes lymphoma hosszú túlélése.
  • The nasal NK/T cell lymphoma is a rare, extranodal non-Hodgkin lymphoma in western civilizations, which has poor prognosis.
  • [MeSH-major] Killer Cells, Natural. Lymphoma, T-Cell, Peripheral / diagnosis. Lymphoma, T-Cell, Peripheral / therapy. Nose Neoplasms / diagnosis. Nose Neoplasms / therapy
  • [MeSH-minor] Aged. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / analysis. Cyclophosphamide / therapeutic use. Diagnosis, Differential. Doxorubicin / therapeutic use. Female. Herpesvirus 4, Human / isolation & purification. Humans. Prednisone / therapeutic use. Tomography, X-Ray Computed. Vincristine / therapeutic use

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  • (PMID = 18426762.001).
  • [ISSN] 0030-6002
  • [Journal-full-title] Orvosi hetilap
  • [ISO-abbreviation] Orv Hetil
  • [Language] hun
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Hungary
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CHOP protocol
  • [Number-of-references] 10
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84. Aozasa K, Takakuwa T, Hongyo T, Yang WI: Nasal NK/T-cell lymphoma: epidemiology and pathogenesis. Int J Hematol; 2008 Mar;87(2):110-7
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  • [Title] Nasal NK/T-cell lymphoma: epidemiology and pathogenesis.
  • Nasal NK/T-cell lymphoma (NKTCL) is an uncommon disease, but usually shows a highly aggressive clinical course.
  • Analyses of gene mutations, especially p53 and c-KIT, revealed the different frequencies by district.
  • [MeSH-major] Killer Cells, Natural / pathology. Lymphoma, T-Cell. Nose Neoplasms

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  • (PMID = 18256789.001).
  • [ISSN] 0925-5710
  • [Journal-full-title] International journal of hematology
  • [ISO-abbreviation] Int. J. Hematol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Pesticide Residues; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
  • [Number-of-references] 75
  • [Other-IDs] NLM/ PMC2276242
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85. Ketharanathan N, van Kipshagen PJ, Vasmel W, Barbé E, de Vries N: T/NK cell lymphoma presenting as a "blocked nose". Eur Arch Otorhinolaryngol; 2008 Sep;265(9):1131-4
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  • [Title] T/NK cell lymphoma presenting as a "blocked nose".
  • We present the case of a 63-year-old Caucasian male who complained of persistent rhinitis and sinusitis accompanied by a total left-sided nasal blockage.
  • The diagnosis nasal T/NK cell lymphoma was established by histopathological investigation.
  • This case was diagnosed as stage IE lymphoma as no other sites were involved.
  • The nasal T/NK cell lymphoma is a rare malignancy, which is known to have an extremely aggressive and destructive course.
  • A high index of clinical suspicion is imperative to ensure early diagnosis and ultimately improve disease outcome.
  • [MeSH-major] Lymphoma, Extranodal NK-T-Cell / diagnosis. Nose Neoplasms / diagnosis
  • [MeSH-minor] Airway Obstruction / diagnosis. Airway Obstruction / etiology. Biomarkers, Tumor / analysis. Biopsy. Diagnosis, Differential. Fatal Outcome. Humans. Immunohistochemistry. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 18188576.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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86. Lu M, Li F, Hou Q: [Clinicopathological analysis of 23 cases of NK/T-cell lymphoma of nasal type]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2009 Jan;23(2):57-60
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  • [Title] [Clinicopathological analysis of 23 cases of NK/T-cell lymphoma of nasal type].
  • OBJECTIVE: To improve the understanding of nasal NK/T-cell lymphoma by analyzing its phenotypic and clinicopathological features.
  • METHOD: Twenty-three cases of nasal NK/T-cell lymphoma diagnosed between 2003 and 2007 in the department of pathology of Guilin Medical College were included in the study.
  • RESULT: 69.9% (16/23) of the nasal NK/T-cell lymphoma occurred in the nasal cavity.
  • 21.74% (5/23) were accompanied by squamous cell carcinoma-like epitheliomatous hyperplasia.
  • CONCLUSION: Nasal NK/T-cell lymphoma is characterized by multiple clinicopathological features.
  • Attention is needed to differentiate the tumor from inflammatory lesions and low grade squamous cell carcinoma.
  • Understanding of various morphological and phenotypic features (i.e. expression of TIA-1, CD56 and CD3, and lack of CD20 and CK) is the key for the diagnosis of nasal NK/T-cell lymphoma.
  • [MeSH-major] Lymphoma, Extranodal NK-T-Cell / pathology. Nose Neoplasms / pathology

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  • (PMID = 19452707.001).
  • [ISSN] 1001-1781
  • [Journal-full-title] Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
  • [ISO-abbreviation] Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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87. Kakimoto K, Inoue T, Nishikawa T, Ishida K, Kawakami K, Kuramoto T, Abe Y, Morita E, Murano N, Toshina K, Murano M, Umegaki E, Egashira Y, Okuda J, Tanigawa N, Hirata I, Katsu K, Higuchi K: Primary CD56+ NK/T-cell lymphoma of the rectum accompanied with refractory ulcerative colitis. J Gastroenterol; 2008;43(7):576-80
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  • [Title] Primary CD56+ NK/T-cell lymphoma of the rectum accompanied with refractory ulcerative colitis.
  • A case of primary NK/T-cell lymphoma of the rectum accompanied with ulcerative colitis (UC) in a 73-year-old man is reported.
  • Total colonoscopy performed 4 months after resolution of refractory UC complicated by cytomegalovirus colitis showed a markedly submucosal tumor in the rectum, which was histologically diagnosed as malignant lymphoma.
  • Therefore, based on a diagnosis of localized rectal lymphoma with UC, proctocolectomy was performed.
  • Based on these findings, the patient was diagnosed with primary CD56+ NK/T-cell lymphoma of the rectum (stage IIE).
  • This is the first case report of primary rectal NK/T-cell lymphoma accompanied with UC.
  • [MeSH-major] Antigens, CD56 / analysis. Colitis, Ulcerative / complications. Lymphoma, Extranodal NK-T-Cell / complications. Rectal Neoplasms / complications

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  • (PMID = 18648746.001).
  • [ISSN] 0944-1174
  • [Journal-full-title] Journal of gastroenterology
  • [ISO-abbreviation] J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antigens, CD56
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88. Wang WH, Li YX, Lin C, Liu XF, Yu ZH, Song YW, Zhang XY, Fu M, Jin J, Wang SL, Liu YP: [Expression profile of nasal NK/T cell lymphoma by cDNA microarray]. Zhonghua Zhong Liu Za Zhi; 2006 Jul;28(7):518-22
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  • [Title] [Expression profile of nasal NK/T cell lymphoma by cDNA microarray].
  • OBJECTIVE: To investigate the changes of gene expression profile in nasal NK/T cell lymphoma.
  • METHODS: Total RNA was extracted from the fresh nasal NK/T cell lymphoma tissue and normal lymph node.
  • A total of 365 (8.9%) genes was found to be differentially expressed by a factor of twofold or greater in both of two identical cDNA microarrays, which included oncogenes, tumor supressor genes, cell cycle regulators, apoptotic and antiapoptotic factors, DNA transcription factors, DNA repair and recombination factors, signal transduction genes, protein translation genes, as well as a large number of metabolic genes.
  • CONCLUSION: This study demonstrates that many different kinds of genes are possibly involved in the initiation and progression of nasal NK/T lymphoma. cDNA microarray technique is useful in screening cancer gene expression for nasal NK/T lymphoma.
  • [MeSH-major] Gene Expression Profiling. Killer Cells, Natural / metabolism. Lymphoma, T-Cell / genetics. Nose Neoplasms / genetics. Oligonucleotide Array Sequence Analysis / methods
  • [MeSH-minor] Antigens, CD20 / genetics. Chemokine CXCL9 / genetics. Gene Expression Regulation, Neoplastic. Humans. Lymph Nodes / metabolism. Lymph Nodes / pathology. Receptors, Immunologic / genetics. Receptors, Natural Killer Cell

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  • (PMID = 17147117.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD20; 0 / CXCL9 protein, human; 0 / Chemokine CXCL9; 0 / Receptors, Immunologic; 0 / Receptors, Natural Killer Cell
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89. Ou CH, Chen CC, Ling JC, Chai JW, Wu CH, Chen WH, Hung HC, Tain-Lee, Ho TL: Nasal NK/T-cell lymphoma: computed tomography and magnetic resonance imaging findings. J Chin Med Assoc; 2007 May;70(5):207-12
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  • [Title] Nasal NK/T-cell lymphoma: computed tomography and magnetic resonance imaging findings.
  • BACKGROUND: Primary nasal natural killer (NK)/T-cell lymphoma is the most common cellular subtype seen in nasal lymphomas.
  • The purpose of this study was to describe the computed tomography (CT) and magnetic resonance (MR) imaging findings of primary nasal NK/T-cell lymphoma.
  • METHODS: During the period between January 1990 and June 2006, the CT (n=24) and MR (n=6) images of 24 patients with biopsy-proved nasal NK/T-cell lymphoma were reviewed retrospectively.
  • RESULTS: The most common symptoms at presentation were nasal obstruction, nasal discharge, and epistaxis.
  • There was involvement of the unilateral nasal cavity in 16, bilateral nasal cavity including nasal septum in 5 and nasal choana in 3.
  • Sites of extension outside the nasal cavity included tumor extension into paranasal sinuses (n=15), nasopharynx (n=5), nasal labial fold (n=3), oropharynx (n=2), infratemporal fossa (n=2), other subcutaneous soft tissue of the face (n=2) and anterior cranial fossa base (n=1).
  • Bony destruction was demonstrated in 18 cases, involving the sinus bony wall (n=15), nasal turbinate (n=10), lamina papyracea (n=6), orbital floor (n=3), and hard palate (n=2).
  • Regional lymphadenopathy was also detected in 3 patients with nasal NK/T-cell lymphoma.
  • CONCLUSION: The CT and MR appearances of nasal NK/T-cell lymphoma are nonspecific, and the diagnosis requires histologic confirmation.
  • However, the differential diagnosis of nasal NK/T-cell lymphoma should be included if the images present soft tissue of the nasal cavity with bony erosion or destruction; involvement of the orbital cavity, nasopharynx and infratemporal fossa; and subcutaneous or nasolabial fold soft tissue infiltration, especially in Asian populations.
  • [MeSH-major] Killer Cells, Natural / pathology. Lymphoma, T-Cell / pathology. Nose Neoplasms / pathology

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  • (PMID = 17524998.001).
  • [ISSN] 1726-4901
  • [Journal-full-title] Journal of the Chinese Medical Association : JCMA
  • [ISO-abbreviation] J Chin Med Assoc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China (Republic : 1949- )
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90. Tamai Y, Imataki O, Abe Y, Hagiwara S, Ito I, Asakura H, Harada H, Kamata M, Nishimura T, Kawakami K: [Case series of localized nasal NK/T-cell lymphoma treated with preceding intensified local radiation therapy before systemic chemotherapy]. Gan To Kagaku Ryoho; 2006 May;33(5):687-90
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  • [Title] [Case series of localized nasal NK/T-cell lymphoma treated with preceding intensified local radiation therapy before systemic chemotherapy].
  • Nasal NK/T-cell lymphoma is EB virus-associated aggressive lymphoma, which is more prevalent in Asia.
  • Previously, this lymphoma which was recognized as lethal midline granuloma, commonly presents with midline facial destructive lesions.
  • We report consecutive 4 cases of nasal NK/T-cell lymphoma, which was treated with 56 Gy intensified local radiation therapy followed by systemic chemotherapy.
  • High intensified radiation therapy followed by chemotherapy may be effective for localized nasal NK/T-cell lymphoma.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Lymphoma, T-Cell / drug therapy. Lymphoma, T-Cell / radiotherapy. Nose Neoplasms / drug therapy. Nose Neoplasms / radiotherapy

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  • (PMID = 16685174.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; 9PHQ9Y1OLM / Prednisolone; VAP-cyclo protocol
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91. Yang F, Liu WP, He MX, Tang QL, Zhao S, Zhang WY, Xia QJ, Li GD: [Real-time fluorescence quantitative PCR in detecting ribosome protein S13 (RPS13) gene expression in NK/T cell lymphoma]. Sichuan Da Xue Xue Bao Yi Xue Ban; 2006 May;37(3):464-6
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  • [Title] [Real-time fluorescence quantitative PCR in detecting ribosome protein S13 (RPS13) gene expression in NK/T cell lymphoma].
  • OBJECTIVE: To quantitatively detect the expression level of ribosome protein S13 (RPS13) in NK/T cell lymphoma.
  • METHODS: The total RNA isolated from the parafin-embedded tissue of NK/T cell lymphoma was reversely transcribed into cDNA.
  • The expression level of RPS13 gene in tumor tissue of 20 cases of NK/T cell lymphoma was dramatically lower than that in normal peripheral blood lymphocyte of healthy controls.
  • CONCLUSION: The RPS13 gene has lower expression level in tumor tissue cells of NK/T cell lymphoma than in normal lymphocyte, indicating that it plays an role in the development of the NK/T cell lymphoma.
  • [MeSH-major] Killer Cells, Natural / metabolism. Lymphoma, T-Cell / metabolism. Nose Neoplasms / metabolism. Ribosomal Proteins / analysis

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  • (PMID = 16761435.001).
  • [ISSN] 1672-173X
  • [Journal-full-title] Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
  • [ISO-abbreviation] Sichuan Da Xue Xue Bao Yi Xue Ban
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / RPS13 protein, human; 0 / Ribosomal Proteins
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92. Zeglaoui I, Belcadhi M, Sriha B, Bouzouita K: Nasal NK/T-cell lymphoma in the paediatric population. Two case reports. B-ENT; 2009;5(2):119-23
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  • [Title] Nasal NK/T-cell lymphoma in the paediatric population. Two case reports.
  • Nasal natural killer (NK)/T-cell lymphoma is an uncommon disease, and only a few paediatric cases are found in the literature.
  • We report 2 cases of NK/T-cell lymphoma occurring in children.
  • The primary site was the the nasal cavity in the first case (5-year-old girl) and the tonsil in the second case (4-year-old boy).
  • Histological study showed a polymorphic neoplastic infiltrate with an angioinvasive pattern and T-cell phenotype.
  • The outcome was favorable for the 4-year old boy; however, the 5-year-old girl died two months after diagnosis.
  • [MeSH-major] Lymphoma, Extranodal NK-T-Cell / diagnosis. Lymphoma, Extranodal NK-T-Cell / therapy. Nose Neoplasms / diagnosis. Nose Neoplasms / therapy. Tonsillar Neoplasms / diagnosis. Tonsillar Neoplasms / therapy

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  • (PMID = 19670600.001).
  • [ISSN] 1781-782X
  • [Journal-full-title] B-ENT
  • [ISO-abbreviation] B-ENT
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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93. Au WY: Current management of nasal NK/T-cell lymphoma. Oncology (Williston Park); 2010 Apr 15;24(4):352-8
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  • [Title] Current management of nasal NK/T-cell lymphoma.
  • Nasal natural killer (NK)/T-cell lymphoma--classified as extranodal NK/T-cell lymphoma (ENKTL), nasal type, by the World Health Organization--is a non-Hodgkin lymphoma that is almost always associated with Epstein-Barr virus.
  • Up to 75% of ENKTL cases occur in the upper aerodigestive tract, primarily the nasal cavity.
  • It is the most common type of peripheral T-cell lymphoma in many Asian countries.
  • Histologic diagnosis is essential, and staging consists of bilateral bone marrow biopsy and imaging of the neck, thorax, abdomen, and pelvis.
  • Early-stage, localized nasal disease is highly curable with combination therapy, but the optimal dose, combination, and sequence of radiotherapy and chemotherapy are still undefined.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Lymphoma, Extranodal NK-T-Cell / therapy. Nose Neoplasms / therapy

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  • [CommentIn] Oncology (Williston Park). 2010 Apr 15;24(4):362-3 [20464849.001]
  • [CommentIn] Oncology (Williston Park). 2010 Apr 15;24(4):359, 362 [20464848.001]
  • (PMID = 20464847.001).
  • [ISSN] 0890-9091
  • [Journal-full-title] Oncology (Williston Park, N.Y.)
  • [ISO-abbreviation] Oncology (Williston Park, N.Y.)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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94. Mehta V, Balachandran C, Bhat S, Geetha V, Fernandes D: Nasal NK/T cell lymphoma presenting as a lethal midline granuloma. Indian J Dermatol Venereol Leprol; 2008 Mar-Apr;74(2):145-7
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  • [Title] Nasal NK/T cell lymphoma presenting as a lethal midline granuloma.
  • Nasal NK/T cell lymphomas are aggressive, locally destructive, midfacial, necrotizing lesions.
  • The nonspecific clinical symptoms constitute a major stumbling block in the early diagnosis and management of these lymphomas.
  • We report here a case of probable nasal NK/T cell lymphoma in an apparently healthy male that progressed rapidly in a short span of time and was managed subsequently with chemotherapy and external beam irradiation with which the lesion regressed.
  • [MeSH-major] Granuloma, Lethal Midline / diagnosis. Lymphoma, T-Cell / diagnosis. Nose Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Killer Cells, Natural / pathology. Male. T-Lymphocyte Subsets / pathology

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  • (PMID = 18388376.001).
  • [ISSN] 0973-3922
  • [Journal-full-title] Indian journal of dermatology, venereology and leprology
  • [ISO-abbreviation] Indian J Dermatol Venereol Leprol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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95. Ren X, Jiang X, Wen B: [Clinical analysis of primary nasal cavity-nasal sinuses T/NK cell lymphoma]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2008 Mar;22(5):220-1, 225
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  • [Title] [Clinical analysis of primary nasal cavity-nasal sinuses T/NK cell lymphoma].
  • OBJECTIVE: To investigate the clinical feature, diagnosis, treatment and prognosis of primary nasal cavity-nasal sinuses T/NK cell lymphoma.
  • METHOD: Twenty-six patients with primary nasal cavity-nasal sinuses T/NK cell lymphoma were retrospectively analyzed.
  • The pathological diagnosis and immunohistochemical tests were performed in 26 cases and 21 cases respectively.
  • CONCLUSION: The primary nasal cavity-nasal sinuses T/NK cell lymphomas are a distinct category of the non-Hodgkin's lymphoma (NHL).
  • [MeSH-major] Lymphoma, Non-Hodgkin. Lymphoma, T-Cell. Nose Neoplasms. Paranasal Sinus Neoplasms
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Humans. Killer Cells, Natural. Male. Middle Aged. Nasal Cavity. Paranasal Sinuses. Retrospective Studies. Young Adult

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  • (PMID = 18476612.001).
  • [ISSN] 1001-1781
  • [Journal-full-title] Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
  • [ISO-abbreviation] Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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96. Nagamine M, Takahara M, Kishibe K, Nagato T, Ishii H, Bandoh N, Ogino T, Harabuchi Y: Sequence variations of Epstein-Barr virus LMP1 gene in nasal NK/T-cell lymphoma. Virus Genes; 2007 Jan;34(1):47-54
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  • [Title] Sequence variations of Epstein-Barr virus LMP1 gene in nasal NK/T-cell lymphoma.
  • Nasal natural killer (NK)/T-cell lymphoma is a peculiar lymphoma with an unique immunophenotype.
  • Etiologically, the authors previously first demonstrated the presence of Epstein-Barr virus (EBV) genomes and their products in this lymphoma (Lancet 1990; 335).
  • In this study, we determined full-length of LMP1 sequence isolated from 7 patients with nasal NK/T-cell lymphoma using polymerase chain reaction (PCR) method and compared the sequences with those referred to previous reports.
  • In the major HLA-A2 restricted T-cell epitope sequence YLLEMLWRL (codon 125-133), all 7 patients showed amino acid changes at codon 126 (Leu to Phe) and 129 (Met to Ile).
  • Although it is still not clear what the most specific and biologic variation of LMP1 gene in nasal NK/T-cell lymphoma is, the sequence data may be valuable on the study for pathogenesis of nasal NK/T-cell lymphoma and EBV molecular epidemiology.
  • [MeSH-major] Genetic Variation. Herpesvirus 4, Human / genetics. Lymphoma, Non-Hodgkin / virology. Lymphoma, T-Cell / virology. Nasal Mucosa / virology. Viral Matrix Proteins / genetics
  • [MeSH-minor] Adult. Aged. Amino Acid Sequence. Base Sequence. Catalytic Domain. DNA Restriction Enzymes / metabolism. Female. Humans. Killer Cells, Natural / pathology. Killer Cells, Natural / virology. Male. Middle Aged. Molecular Sequence Data

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  • (PMID = 16917737.001).
  • [ISSN] 0920-8569
  • [Journal-full-title] Virus genes
  • [ISO-abbreviation] Virus Genes
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / EBV-associated membrane antigen, Epstein-Barr virus; 0 / Viral Matrix Proteins; EC 3.1.21.- / DNA Restriction Enzymes
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97. Lim ST, Hee SW, Quek R, Lim LC, Yap SP, Loong EL, Sng I, Tan LH, Ang MK, Ngeow J, Tham CK, Ngo L, Tan MH, Tao M: Comparative analysis of extra-nodal NK/T-cell lymphoma and peripheral T-cell lymphoma: significant differences in clinical characteristics and prognosis. Eur J Haematol; 2008 Jan;80(1):55-60
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  • [Title] Comparative analysis of extra-nodal NK/T-cell lymphoma and peripheral T-cell lymphoma: significant differences in clinical characteristics and prognosis.
  • AIM: We aimed to compare the frequencies, clinical characteristics, and prognostic factors of peripheral T-cell lymphoma (PTCL) vs. extra-nodal natural killer (NK)/T-cell lymphoma and to characterize the subtypes of extra-nodal NK/T-cell lymphoma.
  • METHODS: We reviewed 97 consecutive patients with PTCL and extra-nodal NKT lymphoma from 2000 to 2006.
  • During this period, a total of 780 patients with malignant lymphomas were treated in our center.
  • The diagnostic criteria used were based on the WHO classification system of malignant lymphomas.
  • RESULTS: Extra-nodal-NK/T-cell lymphoma and PTCL comprised 5.0% (39/780) and 7.4% (58/780) of all cases.
  • Of the PTCL cases, histology was PTCL-NOS in 25, anaplastic large cell in 11, angioimmunoblastic T cell in 18 and other subtypes in four patients.
  • Compared with PTCL, extra-nodal NK/T-cell lymphoma was associated with a significantly inferior rates of complete remission (33% vs. 53%, P = 0.05) and 3 yr overall survival (29.5% vs. 47.5%, P = 0.003).
  • On multivariate analysis, extra-nodal NK/T-cell histology was independently associated with decreased survival.
  • Further analysis into this subtype showed the nasal variant (n = 25) differed significantly from extra-nasal variant (n = 14) in terms of stage at presentation (stages III/IV, 36% vs. 79%), international prognostic index scores (high intermediate or high IPI scores, 24% vs. 64%), complete remission rates (48% vs. 7%), and median survival (10 months vs. 1 month, P < 0.0001).
  • CONCLUSIONS: Extra-nodal NK/T-cell lymphoma was associated with a poorer prognosis compared with PTCL and is likely to comprise two distinct variants with different clinical behavior and prognosis.
  • [MeSH-major] Killer Cells, Natural / pathology. Lymphoma, T-Cell / pathology. Lymphoma, T-Cell, Peripheral / pathology

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  • (PMID = 18028433.001).
  • [ISSN] 1600-0609
  • [Journal-full-title] European journal of haematology
  • [ISO-abbreviation] Eur. J. Haematol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Denmark
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98. Sakata K, Someya M, Omatsu M, Asanuma H, Hasegawa T, Ichimiya S, Hareyama M, Himi T: The enhanced expression of the matrix metalloproteinase 9 in nasal NK/T-cell lymphoma. BMC Cancer; 2007;7:229
MedlinePlus Health Information. consumer health - Nasal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The enhanced expression of the matrix metalloproteinase 9 in nasal NK/T-cell lymphoma.
  • BACKGROUND: Nasal NK/T cell lymphoma is an aggressive disease and has a poor prognosis.
  • Nasal NK/T cell lymphoma is refractory to conventional chemotherapy and has strong tendency of widespread relapse or dissemination into distant sites.
  • METHODS: We immunohistochemically studied nasal NK/T-cell lymphoma to elucidate the unique characteristics of nasal NK/T-cell lymphoma, such as its higher metastatic tendency and its vast necrosis which leads to destruction of the involved tissues.
  • The expression of P-glycoprotein and MMP-9 was evaluated in the 20 patients with nasal NK/T-cell lymphoma and 25 with nasal non-NK/T-cell lymphoma and the relationship between expression of these proteins and clinical results were analyzed in this report.
  • RESULTS: Overall 5-year survival rates for patients with nasal NK/T cell lymphoma, and nasal non-NK/T cell lymphoma were 51%, and 84%.
  • Distant involvement free 5-year survival rates for patients with nasal NK/T cell lymphoma, and nasal non-NK/T cell lymphoma were 53%, and 79%.
  • Sixteen of the 19 patients with nasal NK/T cell lymphoma expressed MMP-9.
  • In contrast, only 8 of the 22 patients with nasal non-NK/T cell lymphoma expressed MMP-9.
  • CONCLUSION: Positive immunoreactivity for P-glycoprotein was not an independent prognostic factor in nasal NK/T-cell lymphomas, which stresses the importance of exploring other mechanisms of drug resistance.
  • The strong expression of MMP-9 is uniquely characteristic of nasal NK/T cell lymphoma and may contribute to its strong tendency to disseminatate and the extensive necrosis which is always seen.
  • [MeSH-major] Lymphoma, Extranodal NK-T-Cell / metabolism. Lymphoma, Extranodal NK-T-Cell / pathology. Matrix Metalloproteinase 9 / metabolism. Nasal Cavity / pathology. Nose Neoplasms / metabolism. Nose Neoplasms / pathology

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  • [ErratumIn] BMC Cancer. 2008;8:45. Ichimiya, Shingo [added]
  • (PMID = 18093334.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / P-Glycoprotein; EC 3.4.24.35 / Matrix Metalloproteinase 9
  • [Other-IDs] NLM/ PMC2238761
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99. Kim K, Chie EK, Kim CW, Kim IH, Park CI: Treatment outcome of angiocentric T-cell and NK/T-cell lymphoma, nasal type: radiotherapy versus chemoradiotherapy. Jpn J Clin Oncol; 2005 Jan;35(1):1-5
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Treatment outcome of angiocentric T-cell and NK/T-cell lymphoma, nasal type: radiotherapy versus chemoradiotherapy.
  • OBJECTIVE: The purpose of this study was to evaluate the treatment outcome of angiocentric T-cell and natural killer (NK)/T-cell lymphoma, nasal type.
  • METHODS: Between February 1989 and March 2001, 53 patients with newly diagnosed angiocentric T-cell and NK/T-cell lymphoma, nasal type involving the head and neck, were treated with radiation therapy (RT).
  • CONCLUSIONS: There was no difference in survival between RT and CRT in angiocentric T-cell and NK/T-cell lymphoma, nasal type.
  • [MeSH-major] Killer Cells, Natural. Lymphoma, T-Cell / drug therapy. Lymphoma, T-Cell / radiotherapy. Nose Neoplasms / drug therapy. Nose Neoplasms / radiotherapy

  • MedlinePlus Health Information. consumer health - Nasal Cancer.
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  • (PMID = 15681596.001).
  • [ISSN] 0368-2811
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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100. Nagamine M, Kishibe K, Takahara M, Nagato T, Ishii H, Bandoh N, Ogino T, Harabuchi Y: Selected amino acid change encoding Epstein-Barr virus-specific T cell epitope of the LMP2A gene in Japanese nasal NK/T cell lymphoma patients. Intervirology; 2007;50(5):319-22
MedlinePlus Health Information. consumer health - Nasal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Selected amino acid change encoding Epstein-Barr virus-specific T cell epitope of the LMP2A gene in Japanese nasal NK/T cell lymphoma patients.
  • Nasal natural killer (NK)/T cell lymphoma is a peculiar lymphoma with a unique immunophenotype.
  • Etiologically, in 1990, the authors first demonstrated the presence of Epstein-Barr virus (EBV) genomes and their products in this lymphoma.
  • Amino acid changes encoding the CTL epitope on the lymphoma cells may result in a reduced CTL response.
  • We focused on two major CTL epitopes SSCSSCPLSK (codon 340 to 349) and FLYALALLLL (codon 356 to 364) of the LMP2A gene and determined the sequence isolated from nasal NK/T cell lymphoma tissues.
  • All isolates from 7 nasal NK/T cell lymphomas showed the same amino acid change from serine to threonine at codon 348 in the CTL epitope SSCSSCPLSK.
  • The predominant threonine substitution of nasal NK/T cell lymphoma patients may represent disease-associated polymorphism rather than a geographic or race-associated polymorphism.
  • The LMP2A strain including threonine substitution at codon 348 may be selected within tumors and play a role for tumor genesis in Japanese patients with nasal NK/T cell lymphoma through reduced immune recognition.
  • [MeSH-major] Amino Acid Substitution / genetics. Antigens, Viral / genetics. Epitopes, T-Lymphocyte / genetics. Herpesvirus 4, Human / genetics. Lymphoma, T-Cell / virology. Nose Neoplasms / virology. Viral Matrix Proteins / genetics

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  • [Copyright] (c) 2007 S. Karger AG, Basel.
  • (PMID = 17657160.001).
  • [ISSN] 1423-0100
  • [Journal-full-title] Intervirology
  • [ISO-abbreviation] Intervirology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Antigens, Viral; 0 / EBV-associated membrane antigen, Epstein-Barr virus; 0 / Epitopes, T-Lymphocyte; 0 / Viral Matrix Proteins
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