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1. Moradi S, Chavoshzadeh Z, Izadyar M, Mahjoub F, Rezaei N: Angiocentric nasal T-cell lymphoma in a patient withidiopathic CD4+ lymphocytopenia. Iran J Allergy Asthma Immunol; 2009 Dec;8(4):215-8
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  • [Title] Angiocentric nasal T-cell lymphoma in a patient withidiopathic CD4+ lymphocytopenia.
  • Idiopathic CD4+ Lymphocytopenia is a rare combined immunodeficiency disease, characterized by low CD4+ T-cell count and increased susceptibility to opportunistic infections, autoimmunity and malignancies after exclusion of secondary forms of CD4 lymphocytopenia.
  • He had a history of recurrent otitis media, chronic diarrhea, arthritis and herpetic lesions of eyes and mouth since the age of 5 years.
  • Immunohistological studies of destructive lesions in oral and nasal cavity revealed angiocentric T-cell lymphoma.
  • This patient is the first reported case of lethal midline granuloma with origin T-cell lymphoma in idiopathic CD4+ lymphocytopenia.
  • [MeSH-major] CD4-Positive T-Lymphocytes / pathology. Lymphoma, T-Cell. Lymphopenia. Nose Neoplasms

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  • (PMID = 20404393.001).
  • [ISSN] 1735-1502
  • [Journal-full-title] Iranian journal of allergy, asthma, and immunology
  • [ISO-abbreviation] Iran J Allergy Asthma Immunol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Iran
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2. Reddy RR, Singh G, Prathima KJ, Harendra Kumar ML: CD-3 positive extranodal T-cell lymphoma of nasal type with skin involvement. Indian J Dermatol Venereol Leprol; 2006 May-Jun;72(3):215-7
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  • [Title] CD-3 positive extranodal T-cell lymphoma of nasal type with skin involvement.
  • A 40-year-old previously healthy lady presented with nasal obstruction and localized plaques over the right arm.
  • She developed complete nasal obstruction due to a mass in the right nasal cavity and skin lesions that ulcerated to present as ecthyma gangrenosum like lesions.
  • Nasal and skin biopsy revealed angiocentric T-cell lymphoma, which on immuno-phenotyping revealed CD-3 positive; and CD-20, CD-30, ALK and EMA negativity.
  • Final diagnosis of CD-3 positive extranodal T-cell lymphoma of nasal type was made.
  • Extranodal T-cell lymphomas are very aggressive NHLs with poor prognosis.
  • NK/T cell lymphoma of nasal type is common with EBV association.
  • [MeSH-major] Lymphoma, T-Cell / pathology. Nose Neoplasms / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Antigens, CD3 / metabolism. Ecthyma / pathology. Fatal Outcome. Female. Humans

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  • (PMID = 16766837.001).
  • [ISSN] 0378-6323
  • [Journal-full-title] Indian journal of dermatology, venereology and leprology
  • [ISO-abbreviation] Indian J Dermatol Venereol Leprol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Antigens, CD3
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3. Peral-Cagigal B, Galdeano-Arenas M, Crespo-Pinilla JI, García-Cantera JM, Sánchez-Cuéllar LA, Verrier-Hernández A: Centrofacial angiocentric lymphoma. Med Oral Patol Oral Cir Bucal; 2005 Jan-Feb;10(1):92-4; 90-2
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  • [Title] Centrofacial angiocentric lymphoma.
  • The centrofacial angiocentric lymphoma is a rare lymphoid neoplasm, with an often-difficult diagnosis due to the non-specific clinical picture.
  • On many occasions it is necessary to perform various biopsies to reach the correct diagnosis.
  • This lymphoma is an aggressive Non-Hodgkin's (NHL) type, which is normally found in the upper respiratory tract (predominantly in the nasal cavity), and has an ominous prognosis, as the average survival rate is between 12 and 18 months (1).
  • This is the case study of a female Ecuadorian patient who was referred to our department with a hemifacial edema, chocolate- like rhinorrhea and nasal respiratory obstruction, which had been treated with antibiotics and anti-inflammatories for a month without success.
  • After performing a number of diagnostic tests, it was found histologically that the patient had an extranodal T-cell lymphoma of the nasal type (also known as T-cell angiocentric lymphoma).
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Lymphoma, T-Cell / diagnosis
  • [MeSH-minor] Adult. Female. Humans

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  • (PMID = 15627913.001).
  • [ISSN] 1698-4447
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng; spa
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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4. Bossard C, Belhadj K, Reyes F, Martin-Garcia N, Berger F, Kummer JA, Brière J, Baglin AC, Cheze S, Bosq J, Ribrag V, Gisselbrecht C, Mounier N, Gaulard P: Expression of the granzyme B inhibitor PI9 predicts outcome in nasal NK/T-cell lymphoma: results of a Western series of 48 patients treated with first-line polychemotherapy within the Groupe d'Etude des Lymphomes de l'Adulte (GELA) trials. Blood; 2007 Mar 1;109(5):2183-9

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  • [Title] Expression of the granzyme B inhibitor PI9 predicts outcome in nasal NK/T-cell lymphoma: results of a Western series of 48 patients treated with first-line polychemotherapy within the Groupe d'Etude des Lymphomes de l'Adulte (GELA) trials.
  • Nasal NK/T-cell lymphoma is a rare disease entity with a poor outcome.
  • Forty-eight patients with nasal T/NK-cell lymphoma who received first-line polychemotherapy (n = 44) or chemoradiotherapy (n = 4) were analyzed for expression of active caspase-3 (aC3), granzyme B protease inhibitor 9 (PI9), and Bcl-2 proteins.
  • Lymphomas were CD3+/CD5-/granzyme B+ and EBV-associated.
  • In view of its constitutive expression by normal NK cells, it is suggested that loss of PI9 expression in tumor cells may reflect some mechanism associated with progression.
  • [MeSH-major] Granzymes / antagonists & inhibitors. Killer Cells, Natural / enzymology. Lymphoma, T-Cell / drug therapy. Lymphoma, T-Cell / metabolism. Serpins / metabolism. T-Lymphocytes / enzymology
  • [MeSH-minor] Adult. Aged. Drug Therapy, Combination. Female. Humans. Male. Middle Aged. Nose / immunology. Nose / pathology. Phenotype. Prognosis. Survival Rate. Treatment Outcome

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  • (PMID = 17077322.001).
  • [ISSN] 0006-4971
  • [Journal-full-title] Blood
  • [ISO-abbreviation] Blood
  • [Language] eng
  • [Publication-type] Controlled Clinical Trial; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / SERPINB9 protein, human; 0 / Serpins; EC 3.4.21.- / Granzymes
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5. Johnson CD, Busaidy KF, Bouquot JE: Oral and maxillofacial pathology case of the month. Angiocentric T-Cell lymphoma (midline lethal granuloma). Tex Dent J; 2007 Aug;124(8):764-5, 772-3
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  • [Title] Oral and maxillofacial pathology case of the month. Angiocentric T-Cell lymphoma (midline lethal granuloma).
  • [MeSH-major] Granuloma, Lethal Midline / pathology. Lymphoma, T-Cell / pathology. Maxillary Neoplasms / pathology. Maxillary Sinus Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Killer Cells, Natural / pathology. Male. Middle Aged. Neoplasm Invasiveness. Nose Neoplasms / pathology. Osteonecrosis / etiology. Osteonecrosis / pathology. Pseudomonas Infections / complications. Pseudomonas Infections / pathology

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  • (PMID = 17867546.001).
  • [ISSN] 0040-4284
  • [Journal-full-title] Texas dental journal
  • [ISO-abbreviation] Tex Dent J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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6. Chow C, Liu AY, Chan WS, Lei KI, Chan WY, Lo AW: AKT plays a role in the survival of the tumor cells of extranodal NK/T-cell lymphoma, nasal type. Haematologica; 2005 Feb;90(2):274-5
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  • [Title] AKT plays a role in the survival of the tumor cells of extranodal NK/T-cell lymphoma, nasal type.
  • Phosphorylated AKT has been detected in extranodal NK/T-cell lymphoma, nasal type (ENTL).
  • Either interleukin-2 (IL-2) or interleukin-15 (IL-15) could prevent AKT dephosphorylation and apoptosis in the NK-92 cell line model.
  • [MeSH-major] Killer Cells, Natural / cytology. Lymphoma, T-Cell / immunology. Nose Neoplasms / immunology. Proto-Oncogene Proteins c-akt / physiology
  • [MeSH-minor] Cell Line, Tumor. Cell Survival. Humans. Immunohistochemistry. Immunophenotyping. Interleukin-15 / blood. Interleukin-15 / metabolism. Interleukin-2 / metabolism. Lymphoma / pathology. Phosphorylation

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  • (PMID = 15710591.001).
  • [ISSN] 1592-8721
  • [Journal-full-title] Haematologica
  • [ISO-abbreviation] Haematologica
  • [Language] eng
  • [Publication-type] Letter; Research Support, Non-U.S. Gov't
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Interleukin-15; 0 / Interleukin-2; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt
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7. Gill H, Liang RH, Tse E: Extranodal natural-killer/t-cell lymphoma, nasal type. Adv Hematol; 2010;2010:627401

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  • [Title] Extranodal natural-killer/t-cell lymphoma, nasal type.
  • The World Health Organization (WHO) classification recognizes 2 main categories of natural killer (NK) cell-derived neoplasms, namely, extranodal NK/T-cell lymphoma, nasal type, and aggressive NK-cell leukaemia.
  • Extranodal nasal NK/T-cell lymphoma is more frequent in the Far East and Latin America.
  • Early stage disease, in particular for localized lesion in the nasal region, is treated with chemotherapy and involved-field radiotherapy.
  • The role of autologous hematopoietic stem cell transplantation is yet to be clearly defined.
  • Allogeneic hematopoietic stem cell transplantation, with the putative graft-versus-lymphoma effect, offers a potentially curative option in patients with advanced disease.

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  • (PMID = 21234094.001).
  • [ISSN] 1687-9112
  • [Journal-full-title] Advances in hematology
  • [ISO-abbreviation] Adv Hematol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3018635
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8. Lee J, Kim WS, Park YH, Park SH, Park KW, Kang JH, Lee SS, Lee SI, Lee SH, Kim K, Jung CW, Ahn YC, Ko YH, Park K: Nasal-type NK/T cell lymphoma: clinical features and treatment outcome. Br J Cancer; 2005 Apr 11;92(7):1226-30
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  • [Title] Nasal-type NK/T cell lymphoma: clinical features and treatment outcome.
  • Nasal-type NK/T cell lymphoma is an increasingly recognised disease entity of aggressive clinical behaviour.
  • The objective of this study was to investigate clinical features and treatment outcomes in patients with nasal-type NK/T cell lymphoma.
  • From January 1991 to December 2003, 26 patients diagnosed as nasal-type NK/T cell lymphoma were included in the analysis.
  • The median survival for 26 patients with nasal-type NK/T cell lymphoma was 7.4 months (95% CI, 0.1, 16.9).
  • In conclusion, Nasal-type NK/T cell lymphomas showed a poor response to the conventional anthracycline-based chemotherapy, and thus an investigation for an innovative therapy is urgently needed to improve survival in these patients.
  • [MeSH-major] Nasal Cavity / pathology. Neoplasm Staging. Nose Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Anthracyclines / therapeutic use. Antineoplastic Agents / therapeutic use. Female. Health Status. Humans. Killer Cells, Natural. Lymphoma, T-Cell. Male. Middle Aged. Multivariate Analysis. Prognosis. Retrospective Studies. Survival Analysis

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  • (PMID = 15798768.001).
  • [ISSN] 0007-0920
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anthracyclines; 0 / Antineoplastic Agents
  • [Other-IDs] NLM/ PMC2361983
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9. Yoshioka T, Harada M, Umekita Y, Taguchi S, Higashi M, Nakamura D, Suzuki S, Tanimoto A: Necrotizing sialometaplasia of the parotid gland associated with angiocentric T-cell lymphoma: a case report and review of the literature. Pathol Int; 2010 Apr;60(4):326-9
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  • [Title] Necrotizing sialometaplasia of the parotid gland associated with angiocentric T-cell lymphoma: a case report and review of the literature.
  • A very rare case of necrotizing sialometaplasia of the parotid gland associated with angiocentric T-cell lymphoma was described.
  • Angiocentric pattern or vascular invasion by the lymphoid cells was observed and the involved parotid gland exhibited squamous metaplasia of the ducts and acini; necrotizing sialometaplasia.
  • Immunohistochemical analysis revealed a cytotoxic T-cell phenotype of the lymphoid cells (CD3+, CD4-, CD5+, CD8+, CD56-, Granzyme B+, TIA-1+, Perforin-) but in situ hybridization showed no relation to Epstein-Barr virus.
  • Although necrotizing sialometaplasia is relatively rare in the parotid gland, angiocentric T-cell lymphoma should be considered for a causative condition of necrotizing sialometaplasia.
  • [MeSH-major] Lymphoma, T-Cell / pathology. Neovascularization, Pathologic / pathology. Parotid Gland / pathology. Sialometaplasia, Necrotizing / pathology

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  • (PMID = 20403036.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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10. Dominguez-Malagon H, Mosqueda-Taylor A, Cano-Valdez AM: Necrotizing sialometaplasia of the palate associated with angiocentric T-cell lymphoma. Ann Diagn Pathol; 2009 Feb;13(1):60-4
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  • [Title] Necrotizing sialometaplasia of the palate associated with angiocentric T-cell lymphoma.
  • In this article we present 2 cases of necrotizing sialometaplasia (NS) associated with angiocentric lymphoma of the midline.
  • Immunohistochemical analysis confirmed a T-cell origin, and in situ hybridization in one case revealed its relationship to Epstein-Barr virus.
  • To our knowledge, the association between angiocentric lymphoma and NS has been previously reported in only one instance, and we suggest that this particular type of lymphoma should be added to the list of related conditions for NS.
  • [MeSH-major] Epstein-Barr Virus Infections / complications. Lymphoma, T-Cell / complications. Palatal Neoplasms / complications. Paranasal Sinus Neoplasms / complications. Sialometaplasia, Necrotizing / diagnosis. Sialometaplasia, Necrotizing / etiology
  • [MeSH-minor] Adult. Female. Herpesvirus 4, Human / genetics. Herpesvirus 4, Human / isolation & purification. Humans. In Situ Hybridization. Male. Palate. Salivary Glands / blood supply. Salivary Glands / pathology

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  • (PMID = 19118785.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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11. Bene NI, Zeitouni NC, Cheney R: Unusual cutaneous manifestation of angiocentric T-cell lymphoma: a case report. Cutis; 2006 May;77(5):310-2
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  • [Title] Unusual cutaneous manifestation of angiocentric T-cell lymphoma: a case report.
  • Angiocentric T-cell lymphoma may clinically present with a broad variety of cutaneous manifestations, including papules, nodules, and ulcerated tumors, and may mimic cutaneous vasculitis and Wegener granulomatosis.
  • Histologic diagnosis of angiocentric T-cell lymphoma also may present a challenge because of variations in the degree of cellular infiltrate and cellular atypia.
  • The correct diagnosis is critical because of the importance of choosing the correct therapeutic modality-chemotherapy or x-ray radiation.
  • We report a case of angiocentric T-cell lymphoma with extensive necrotic facial ulcers that responded to treatment with fludarabine, cyclophosphamide, and prednisone.
  • [MeSH-major] Facial Neoplasms / pathology. Lymphoma, T-Cell, Cutaneous / pathology. Skin Neoplasms / pathology

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  • (PMID = 16776287.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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12. Laetsch B, Hofbauer G, Kempf W, Burg G, Dummer R: Atypical poorly differentiated cutaneous T-cell lymphoma with an angiocentric growth pattern presenting histologically as vasculitis. Dermatology; 2005;210(4):341-5
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  • [Title] Atypical poorly differentiated cutaneous T-cell lymphoma with an angiocentric growth pattern presenting histologically as vasculitis.
  • We report the case of a 41-year-old patient with an aggressive cutaneous T-cell lymphoma (CTCL) initially presenting on histology as lymphocytic vasculitis.
  • On repeated histological examination and by molecular biology work-up, the diagnosis of an unclassifiable CTCL could eventually be established.
  • This atypical poorly differentiated lymphoma was of a CD4+ CD8- CD56- phenotype and followed an unfavourable course.
  • The patient died despite chemo- and immunotherapy 7 months after the first consideration of lymphoma as diagnosis.
  • [MeSH-major] Lymphoma, T-Cell, Cutaneous / pathology. Skin Neoplasms / pathology. Vasculitis / pathology
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biopsy, Needle. Diagnosis, Differential. Disease Progression. Fatal Outcome. Humans. Immunohistochemistry. Male. Risk Assessment

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  • [Copyright] 2005 S. Karger AG, Basel
  • (PMID = 15942225.001).
  • [ISSN] 1018-8665
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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13. Morita M, Osawa M, Naruse H, Nakamura H: Primary NK/T-cell lymphoma of the cauda equina: a case report and literature review. Spine (Phila Pa 1976); 2009 Nov 15;34(24):E882-5
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  • [Title] Primary NK/T-cell lymphoma of the cauda equina: a case report and literature review.
  • OBJECTIVE: To describe an unusual case of primary lymphoma of the cauda equina and provide a review of the literature of this condition.
  • SUMMARY OF BACKGROUND DATA: Primary lymphoma of the cauda equina is extremely rare, and has been reported in 8 cases previously.
  • This report is the first to describe a case of primary nasal type NK/T-cell lymphoma of the cauda equina.
  • METHODS: We report the case of a 67-year-old man presenting the symptoms of cauda equina syndrome caused by primary lymphoma of the cauda equina.
  • Further investigations including immunohistochemical stains made a diagnosis of primary nasal type NK/T-cell lymphoma of the cauda equina, and the patient received radiotherapy to the lumbosacral area.
  • Brain metastasis was detected 8 months after surgery, and the patient died 14 months after his initial clinical presentation despite additional treatments including whole-brain radiotherapy and oral chemotherapy.
  • CONCLUSION: Although primary lymphoma of the cauda equina is extremely rare, the prognosis of this condition is thought to be poor.
  • Early definitive diagnosis with examination of the cerebrospinal fluid followed by combined treatment with radiotherapy and high-dose methotrexate should be considered.
  • [MeSH-major] Lumbar Vertebrae / pathology. Lymphoma, Extranodal NK-T-Cell / pathology. Polyradiculopathy / pathology. Spinal Canal / pathology. Spinal Cord Neoplasms / pathology. Spinal Nerve Roots / pathology

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  • (PMID = 19910757.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 19
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14. Kato T, Tanabe J, Kanemoto M, Kobayashi C, Morita S, Karahashi T: A case of extranodal NK/T-cell lymphoma, nasal type mimicking typical manifestations of adult-onset Still's disease (AOSD) with hemophagocytic syndrome: diagnostic consideration between malignant lymphoma without lymphadenopathy and AOSD. Mod Rheumatol; 2009;19(6):675-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of extranodal NK/T-cell lymphoma, nasal type mimicking typical manifestations of adult-onset Still's disease (AOSD) with hemophagocytic syndrome: diagnostic consideration between malignant lymphoma without lymphadenopathy and AOSD.
  • Therefore, the possibility of malignant lymphoma was considered to be extremely low.
  • Leukocytopenia (2.4 x 10(3)/mul) was observed, and thus a diagnosis of adult-onset Still's disease (AOSD) with hemophagocytic syndrome (HPS) was made.
  • Bone marrow aspiration revealed the presence of lymphoma cells and hemophagocytosis, and the CD45 gating analysis showed expanding population of CD2(+), CD3(-), and CD56(+) cells.
  • Further, mucosal ulceration in the nasal cavity was detected.
  • Therefore, a diagnosis of extranodal natural killer (NK)/T-cell lymphoma, nasal type, concomitant with HPS was made, and treatment with dexamethasone, etoposide, ifosfamide, carboplatin (DeVIC) regimen ameliorated his symptoms and platelet transfusion dependency.
  • Later, a high titer of serum EBV-DNA was detected, which supported the diagnosis.
  • Diagnosing AOSD, extranodal presentation of malignant lymphoma such as extranodal NK/T-cell lymphoma, nasal type, should be carefully considered.

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  • (PMID = 19609486.001).
  • [ISSN] 1439-7609
  • [Journal-full-title] Modern rheumatology
  • [ISO-abbreviation] Mod Rheumatol
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 6PLQ3CP4P3 / Etoposide; 7S5I7G3JQL / Dexamethasone; BG3F62OND5 / Carboplatin; UM20QQM95Y / Ifosfamide
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15. Sandner A, Helmbold P, Winkler M, Gattenlöhner S, Müller-Hermelink HK, Holzhausen HJ: Cutaneous dissemination of nasal NK/T-cell lymphoma in a young girl. Clin Exp Dermatol; 2008 Aug;33(5):615-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cutaneous dissemination of nasal NK/T-cell lymphoma in a young girl.
  • In Europe and the USA, the incidence of primary nasal natural killer (NK)/T-cell lymphoma is rare.
  • We describe the case of a 17-year-old white German girl with a primary nasal NK/T-cell lymphoma and cutaneous dissemination.
  • She presented with multiple maculopapular patches involving the trunk and thighs, and a 4-week history of headache, fever and fatigue.
  • Biopsies of the skin and the nasal mucosa were taken.
  • Pathological examination of both specimens revealed a NK/T-cell lymphoma.
  • Epstein-Barr virus RNA was detected in the lymphoma cells by in situ hybridization.
  • [MeSH-major] Epstein-Barr Virus Infections / pathology. Lymphoma, T-Cell / pathology. Lymphoma, T-Cell, Cutaneous / pathology. Nose Neoplasms / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adolescent. Diagnosis, Differential. Fatal Outcome. Female. Humans

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  • (PMID = 18616730.001).
  • [ISSN] 1365-2230
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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16. Kim JH, Lee JH, Lee J, Oh SO, Chang DK, Rhee PL, Kim JJ, Rhee JC, Lee J, Kim WS, Ko YH: Primary NK-/T-cell lymphoma of the gastrointestinal tract: clinical characteristics and endoscopic findings. Endoscopy; 2007 Feb;39(2):156-60

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  • [Title] Primary NK-/T-cell lymphoma of the gastrointestinal tract: clinical characteristics and endoscopic findings.
  • BACKGROUND AND STUDY AIMS: Primary NK-/T-cell lymphoma of the gastrointestinal tract is a very rare disease with a poor prognosis.
  • The aim of this study was to determine the clinical and endoscopic characteristics of patients with primary gastrointestinal NK-/T-cell lymphoma.
  • PATIENTS AND METHODS: The clinical features of 14 patients with primary gastrointestinal NK-/T-cell lymphoma and the endoscopic findings in 11 of these patients were reviewed.
  • Their median age was 42 years (range 23-78) at the time of diagnosis.
  • RESULTS: The initial presenting symptoms of primary gastrointestinal NK-/T-cell lymphoma were gastrointestinal bleeding (n = 6, 42%), abdominal pain (n = 4, 29%), and epigastric soreness (n = 4, 29%).
  • The disease was at an advanced stage at the time of diagnosis: stage II in 5 patients (36%); stage III in 4 (28%); and stage IV in 5 (36%).
  • CONCLUSIONS: Primary gastrointestinal NK-/T-cell lymphoma was endoscopically characterized by superficial/erosive, ulcerative, or ulceroinfiltrative lesions without fungating mass.
  • [MeSH-major] Endoscopy, Gastrointestinal. Gastrointestinal Neoplasms / pathology. Killer Cells, Natural / pathology. Lymphoma, T-Cell / pathology
  • [MeSH-minor] Adult. Aged. Female. Flow Cytometry. Humans. Immunohistochemistry. In Situ Hybridization. Male. Middle Aged. Survival Analysis

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  • (PMID = 17657701.001).
  • [ISSN] 1438-8812
  • [Journal-full-title] Endoscopy
  • [ISO-abbreviation] Endoscopy
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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17. Na II, Kang HJ, Park YH, Lee SS, Yoo HJ, Choe DH, Ryoo BY, Yang SH: Prognostic factors for classifying extranodal NK/T cell lymphoma, nasal type, as lymphoid neoplasia. Eur J Haematol; 2007 Jul;79(1):1-7
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  • [Title] Prognostic factors for classifying extranodal NK/T cell lymphoma, nasal type, as lymphoid neoplasia.
  • This study evaluated the applicability of prognostic factors commonly used for diagnosis of classical lymphoma outcomes to extranodal NK/T cell lymphoma, nasal type (NTCL).
  • Clinical features and their associations with lactate dehydrogenase (LDH) were evaluated in 70 patients.
  • [MeSH-major] Killer Cells, Natural / immunology. Lymphoma, T-Cell / classification. Nose Neoplasms / classification
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Female. Humans. Immunohistochemistry. L-Lactate Dehydrogenase / metabolism. Male. Middle Aged. Prognosis. Treatment Outcome

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  • (PMID = 17598834.001).
  • [ISSN] 0902-4441
  • [Journal-full-title] European journal of haematology
  • [ISO-abbreviation] Eur. J. Haematol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] EC 1.1.1.27 / L-Lactate Dehydrogenase
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18. Lee BH, Kim SY, Kim MY, Hwang YJ, Han YH, Seo JW, Kim YH, Cha SJ, Hur G: CT of nasal-type T/NK cell lymphoma in the lung. J Thorac Imaging; 2006 Mar;21(1):37-9
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  • [Title] CT of nasal-type T/NK cell lymphoma in the lung.
  • Nasal-type T-cell/natural killer cell lymphoma is a new distinctive clinicopathologic entity with a characteristic immunophenotypic expression of CD56.
  • Most cases show a predilection for the nasopharyngeal region and are referred to as nasal T/NK-cell lymphoma.
  • To the best of our knowledge, nasal type T/NK cell lymphoma with isolated lung involvement has not been reported.
  • [MeSH-major] Killer Cells, Natural / pathology. Lung / radiography. Lung Neoplasms / diagnosis. Lymphoma, T-Cell / diagnosis. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Adult. Biopsy, Needle / methods. Diagnosis, Differential. Dyspnea / etiology. Fatal Outcome. Female. Fever / etiology. Humans. Rare Diseases. Sweating / physiology

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  • (PMID = 16538154.001).
  • [ISSN] 0883-5993
  • [Journal-full-title] Journal of thoracic imaging
  • [ISO-abbreviation] J Thorac Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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19. Widmer S, Tinguely M, Egli F, Thiel MA: Lethal Epstein-Barr virus associated NK/T-cell lymphoma with primary manifestation in the conjunctiva. Klin Monbl Augenheilkd; 2005 Mar;222(3):255-7

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  • [Title] Lethal Epstein-Barr virus associated NK/T-cell lymphoma with primary manifestation in the conjunctiva.
  • BACKGROUND: Lethal midline granulomas (LMG) are very rare angiocentric NK/T-cell lymphomas in association with Epstein-Barr virus.
  • Conjunctival biopsy revealed a highly malignant, CD3 + and BCL2 + extranodal T-cell lymphoma with features of an NK/T-cell origin (CD56 +, TIA + TCR-rearrangement: germline).
  • All lymphoma cells were positive for Epstein-Barr virus RNA.
  • THERAPY AND OUTCOME: Systemic 1 (st) cycle chemotherapy with cyclophosphamide, doxorubicin, vincristin and prednisone resulted in a complete remission of the swelling within 4 days.
  • The patient died within a month because of untreatable pancytopenia due to malignant bone marrow infiltration.
  • CONCLUSIONS: LMG is a rare but highly malignant Epstein-Barr virus associated NK/T-cell lymphoma that can occur in healthy, immune competent Caucasians.
  • [MeSH-major] Conjunctival Neoplasms / diagnosis. Epstein-Barr Virus Infections / diagnosis. Eyelid Neoplasms / diagnosis. Granuloma, Lethal Midline / diagnosis. Killer Cells, Natural / pathology. Lymphoma, T-Cell, Peripheral / diagnosis. T-Lymphocytes / pathology
  • [MeSH-minor] Antigens, CD3 / analysis. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biopsy. Conjunctiva / pathology. Eyelids / pathology. Fatal Outcome. Humans. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / drug therapy. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / radiotherapy. Proto-Oncogene Proteins c-bcl-2 / analysis. Radiotherapy, Adjuvant

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  • (PMID = 15785994.001).
  • [ISSN] 0023-2165
  • [Journal-full-title] Klinische Monatsblätter für Augenheilkunde
  • [ISO-abbreviation] Klin Monbl Augenheilkd
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, CD3; 0 / Proto-Oncogene Proteins c-bcl-2
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20. Liu A, Nakatsuka S, Yang WI, Kojya S, Aozasa K: Expression of cell adhesion molecules and chemokine receptors: angioinvasiveness in nasal NK/T-cell lymphoma. Oncol Rep; 2005 Apr;13(4):613-20

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of cell adhesion molecules and chemokine receptors: angioinvasiveness in nasal NK/T-cell lymphoma.
  • Sinonasal natural killer (NK)/T-cell lymphoma (NKTCL) is closely associated with Epstein-Barr virus (EBV) infection and expresses latent membrane protein (LMP)-1 and EB nuclear antigen (EBNA)-1, i.e., latency II of EBV infection.
  • To elucidate the molecular mechanism of angio-invasiveness in NKTCL, expression of cell adhesion molecules and chemokine receptors at mRNA and protein levels was examined using real-time PCR and immunohistochemistry in 17 NKTCL together with 10 diffuse large B-cell lymphoma (DLBL) and 9 non-neoplastic nasal mucosa as controls.
  • [MeSH-major] Killer Cells, Natural / pathology. Lymphoma, T-Cell / metabolism. Lymphoma, T-Cell / pathology. Neovascularization, Pathologic. Receptors, Chemokine / biosynthesis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antigens, Viral / chemistry. Cell Adhesion. Cell Line, Tumor. DNA Primers / chemistry. DNA, Complementary / metabolism. Epstein-Barr Virus Nuclear Antigens / biosynthesis. Female. Humans. Immunohistochemistry. Immunophenotyping. In Situ Hybridization. Male. Middle Aged. Models, Biological. Nasal Mucosa / pathology. RNA / metabolism. RNA, Messenger / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Up-Regulation. Viral Matrix Proteins / biosynthesis. Viral Proteins / chemistry. Virus Latency

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  • (PMID = 15756432.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antigens, Viral; 0 / DNA Primers; 0 / DNA, Complementary; 0 / EBV-associated membrane antigen, Epstein-Barr virus; 0 / Epstein-Barr Virus Nuclear Antigens; 0 / RNA, Messenger; 0 / Receptors, Chemokine; 0 / Viral Matrix Proteins; 0 / Viral Proteins; 63231-63-0 / RNA
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21. Miles RR, Afify Z, Yaish H, Perkins SL: CD56-negative extranodal nasal type NK/T-cell lymphoma. Pediatr Blood Cancer; 2010 Jul 15;55(1):186-9
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  • [Title] CD56-negative extranodal nasal type NK/T-cell lymphoma.
  • Extranodal natural killer (NK)/T-cell lymphoma, nasal type, is a rare lymphoma that occurs predominantly in Asian adults.
  • In this report, we describe the clinical and pathologic features of an unusual aggressive lymphoid neoplasm in a child and review the literature on NK/T-cell lymphoma in children.
  • This case represents an extranodal NK/T-cell lymphoma, nasal type, with an unusual lack of CD56.
  • [MeSH-major] Lymphoma, Extranodal NK-T-Cell / drug therapy

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  • (PMID = 20486184.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD56
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22. Kim SJ, Oh SY, Hong JY, Chang MH, Lee DH, Huh J, Ko YH, Ahn YC, Kim HJ, Suh C, Kim K, Kim WS: When do we need central nervous system prophylaxis in patients with extranodal NK/T-cell lymphoma, nasal type? Ann Oncol; 2010 May;21(5):1058-63
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  • [Title] When do we need central nervous system prophylaxis in patients with extranodal NK/T-cell lymphoma, nasal type?
  • BACKGROUND: The incidence and risk factors of central nervous system (CNS) invasion is still unclear in extranodal natural killer (NK)/T-cell lymphoma, nasal type.
  • PATIENTS AND METHODS: We analyzed 208 patients to study the clinical features and outcomes of CNS disease in extranodal NK/T-cell lymphoma.
  • The clinical variables associated with CNS disease were Ann Arbor stage III/IV (15.87%, P <0.001), regional lymph node involvement (10.41%, P = 0.006), group III/IV of NK/T-cell lymphoma prognostic index (NKPI; 10.20%, P = 0.003), high/high-intermediate international prognostic index (9.30%, P = 0.072) and extra-upper aerodigestive primary sites (9.75%, P = 0.008).
  • In multivariate analysis, NKPI retained the strongest statistical power to predict CNS disease (P = 0.007, relative risk 9.289, 95% confidence interval 1.828-47.212) in extranodal NK/T-cell lymphoma.
  • CONCLUSIONS: Despite extranodal NK/T-cell lymphoma frequently involves paranasal sinus, a routine CNS evaluation and prophylaxis do not seem to be necessary in NKPI group I or II patients due to a very low incidence.

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  • (PMID = 19850636.001).
  • [ISSN] 1569-8041
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] England
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23. Shim SJ, Yang WI, Shin E, Koom WS, Kim YB, Cho JH, Suh CO, Kim JH, Kim GE: Clinical significance of cyclooxygenase-2 expression in extranodal natural killer (NK)/T-cell lymphoma, nasal type. Int J Radiat Oncol Biol Phys; 2007 Jan 1;67(1):31-8
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  • [Title] Clinical significance of cyclooxygenase-2 expression in extranodal natural killer (NK)/T-cell lymphoma, nasal type.
  • PURPOSE: To determine whether there are any differences in therapeutic response, patterns of systemic recurrence, and prognosis of patients with extranodal natural killer (NK)/T-cell lymphoma, nasal type, by the cyclooxygenase-2 (COX-2) expression.
  • PATIENTS AND METHODS: Thirty-four patients with Ann Arbor Stage I and II extranodal NK/T-cell lymphoma who underwent chemotherapy or radiotherapy, or both, were retrospectively reviewed.
  • These patients were divided into two groups according to their immunohistochemical staining for COX-2 expressions: a COX-2-negative group (n = 10 patients) and a COX-2-positive group (n = 24 patients).
  • RESULTS: There was no significant difference in the clinical profiles between the COX-2-negative and COX-2-positive groups.
  • Compared with the patients in the COX-2-negative group, those in the COX-2-positive group had a significantly lower 2-year systemic recurrence-free survival rate (100% for the COX-2-negative group vs. 54% for the COX-2-positive group) (p = 0.02) and a decreased 5-year overall survival rate (70% for the COX-2-negative group vs. 32% for the COX-2-positive group) (p = 0.06).
  • CONCLUSION: Cyclooxygenase-2 expression can serve as a predictive factor for poor treatment response, higher systemic recurrence, and unfavorable prognosis in patients with extranodal NK/T-cell lymphoma, nasal type.
  • [MeSH-major] Cyclooxygenase 2 / metabolism. Head and Neck Neoplasms / metabolism. Lymphoma, T-Cell / metabolism. Neoplasm Proteins / metabolism
  • [MeSH-minor] Adolescent. Adult. Aged. Disease-Free Survival. Female. Humans. Male. Middle Aged. Nose Neoplasms / drug therapy. Nose Neoplasms / metabolism. Nose Neoplasms / radiotherapy. Prognosis. Recurrence. Remission Induction. Retrospective Studies. Treatment Outcome

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  • (PMID = 17049184.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Neoplasm Proteins; EC 1.14.99.1 / Cyclooxygenase 2
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24. Yao B, Li YX, Fang H, Yu ZH, Jin J, Liu XF: [Prognostic factors and treatment outcome in early stage nasal NK/T cell lymphoma]. Zhonghua Xue Ye Xue Za Zhi; 2006 Apr;27(4):222-5
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  • [Title] [Prognostic factors and treatment outcome in early stage nasal NK/T cell lymphoma].
  • OBJECTIVE: To analyze initial response rate of radiotherapy and chemotherapy for early nasal NK/T-cell lymphoma, and its prognostic factors.
  • METHODS: From January 1996 to December 2002, 116 patients with nasal NK/T-cell lymphoma were diagnosed pathologically.
  • Addition of chemotherapy to radiotherapy do not improve the survival of patients with early stage nasal NK/T-cell lymphoma.
  • Radiotherapy is the primary treatment for stage I and II nasal NK/T-cell lymphoma.
  • [MeSH-major] Lymphoma, Extranodal NK-T-Cell / therapy. Nasal Cavity. Nose Neoplasms / therapy
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Combined Modality Therapy. Drug Therapy / methods. Drug Therapy / statistics & numerical data. Female. Follow-Up Studies. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Prognosis. Proportional Hazards Models. Radiotherapy / methods. Radiotherapy / statistics & numerical data. Treatment Outcome. Young Adult

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  • (PMID = 16875550.001).
  • [ISSN] 0253-2727
  • [Journal-full-title] Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
  • [ISO-abbreviation] Zhonghua Xue Ye Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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25. Kim HJ, Bang SM, Lee J, Kwon HC, Suh C, Kim HJ, Lee JH, Ryoo BY, Park YH, Kwon JM, Oh SY, Lee HR, Kim K, Jung CW, Park K, Kim WS: High-dose chemotherapy with autologous stem cell transplantation in extranodal NK/T-cell lymphoma: a retrospective comparison with non-transplantation cases. Bone Marrow Transplant; 2006 May;37(9):819-24
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  • [Title] High-dose chemotherapy with autologous stem cell transplantation in extranodal NK/T-cell lymphoma: a retrospective comparison with non-transplantation cases.
  • To determine the role of high-dose chemotherapy and autologous stem cell transplantation (HDC/ASCT) in extranodal NK/T-cell lymphoma patients, we conducted a retrospective analysis.
  • In conclusion, HDC/ASCT may be considered as a treatment option for patients with extranodal NK/T-cell lymphoma, especially those in CR, with advanced disease (stage III/IV or EUNKTL) and high NKIPI scores.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Lymphoma, T-Cell / therapy. Stem Cell Transplantation / methods
  • [MeSH-minor] Adolescent. Adult. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Retrospective Studies. Survival Analysis. Survivors. Time Factors. Transplantation, Autologous. Treatment Outcome

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  • [Copyright] Bone Marrow Transplantation (2006) 37, 819-824. doi:10.1038/sj.bmt.1705349; published online 20 March 2006.
  • (PMID = 16547486.001).
  • [ISSN] 0268-3369
  • [Journal-full-title] Bone marrow transplantation
  • [ISO-abbreviation] Bone Marrow Transplant.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
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26. Romero-Guadarrama MB, Aguilar-Martínez E: Extranodal nasal NK/T-cell lymphoma with dissemination to the central nervous system: a case report. Acta Cytol; 2010 Sep-Oct;54(5 Suppl):993-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extranodal nasal NK/T-cell lymphoma with dissemination to the central nervous system: a case report.
  • BACKGROUND: Lymphomas that infiltrate the nervous system in children correspond to those of precursor B cells, such as lymphoblastic and Burkitt's lymphoma.
  • In adults, infiltration occurs in mature B-cell lymphomas, such as mantle cell lymphoma, and, rarely, in Hodgkin's lymphoma or peripheral NK/T-cell lymphomas.
  • CASE: We report the case of a 48-year-old man, who two years before death was diagnosed with extranodal nasal NK/T-cell lymphoma nasal in the left nostril.
  • He received radiotherapy and a year later presented tumor activity.
  • Infiltration to the central nervous system was revealed by computed axial tomography, and cytologic study of cerebrospinal fluid revealed malignant lymphoid cells; he then received intrathecal chemotherapy.
  • CONCLUSION: In Mexico, extranodal nasal NK/T-cell lymphoma occurs frequently.
  • [MeSH-major] Central Nervous System / pathology. Lymphoma, Extranodal NK-T-Cell / pathology. Nose Neoplasms / pathology
  • [MeSH-minor] Antigens, CD3 / metabolism. Bone Marrow Cells / pathology. Cell Nucleus / pathology. Cerebrospinal Fluid / cytology. Fatal Outcome. Humans. Male. Middle Aged. Nasal Cavity / pathology. Vacuoles / pathology

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  • (PMID = 21053585.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD3
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27. Deneau M, Wallentine J, Guthery S, O'Gorman M, Bohnsack J, Fluchel M, Bezzant J, Pohl JF: Natural killer cell lymphoma in a pediatric patient with inflammatory bowel disease. Pediatrics; 2010 Oct;126(4):e977-81
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  • [Title] Natural killer cell lymphoma in a pediatric patient with inflammatory bowel disease.
  • Intestinal inflammation continued and impaired his quality of life; he was diagnosed with IBD of an undetermined type (IBD-U).
  • Skin biopsy revealed an atypical lymphoid infiltrate consistent with an Epstein-Barr virus (EBV)-positive natural killer (NK)/T-cell lymphoma with associated hemophagocytic lymphohistiocytosis.
  • Bone marrow biopsy revealed a similar EBV-positive lymphoid infiltrate consistent with an NK/T-cell lymphoma.
  • Flow-cytometric analysis revealed an atypical, clonal NK-cell population, and biopsy specimens from several tissue sites tested positive for CD3, CD56, and CD30.
  • The patient died soon after the diagnosis was made.
  • [MeSH-major] Inflammatory Bowel Diseases / complications. Inflammatory Bowel Diseases / drug therapy. Lymphoma, Extranodal NK-T-Cell / complications

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  • (PMID = 20837584.001).
  • [ISSN] 1098-4275
  • [Journal-full-title] Pediatrics
  • [ISO-abbreviation] Pediatrics
  • [Language] eng
  • [Grant] United States / NCATS NIH HHS / TR / UL1 TR000077
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Gastrointestinal Agents; 0 / Tumor Necrosis Factor-alpha; B72HH48FLU / Infliximab
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28. Takeuchi K, Yokoyama M, Ishizawa S, Terui Y, Nomura K, Marutsuka K, Nunomura M, Fukushima N, Yagyuu T, Nakamine H, Akiyama F, Hoshi K, Matsue K, Hatake K, Oshimi K: Lymphomatoid gastropathy: a distinct clinicopathologic entity of self-limited pseudomalignant NK-cell proliferation. Blood; 2010 Dec 16;116(25):5631-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Lymphomatoid gastropathy: a distinct clinicopathologic entity of self-limited pseudomalignant NK-cell proliferation.
  • Diagnostic errors in distinguishing between malignant and reactive processes can cause serious clinical consequences.
  • We report 10 cases of unrecognized self-limited natural killer-cell proliferation in the stomach, designated as lymphomatoid gastropathy (LyGa).
  • The cells were CD2(+/-), sCD3(-), cCD3(+), CD4(-), CD5(-), CD7(+), CD8(-), CD16(-), CD20(-), CD45(+), CD56(+), CD117(-), CD158a(-), CD161(-), T cell-restricted intracellular antigen-1(+), granzyme B(+), perforin(+), Epstein-Barr early RNA(-), T-cell receptor αβ(-), and T-cell receptor γδ(-).
  • Analysis of the 16 specimens biopsied from 10 patients led to a diagnosis of lymphoma or suspected lymphoma in 11 specimens, gastritis for 1 specimen, adenocarcinoma for 1 specimen, and LyGa or suspected LyGa for 3 specimens.
  • According to conventional histopathologic criteria, LyGa is probably diagnosed as lymphoma, especially as extranodal natural killer/T-cell lymphoma, nasal type.
  • However, LyGa is recognized as a pseudomalignant process because of its clinical characteristics.
  • [MeSH-major] Killer Cells, Natural / pathology. Lymphoma, T-Cell / pathology. Stomach Diseases / pathology
  • [MeSH-minor] Aged. Blotting, Western. Epstein-Barr Virus Infections / diagnosis. Epstein-Barr Virus Infections / genetics. Epstein-Barr Virus Infections / metabolism. Female. Flow Cytometry. Gene Rearrangement. Herpesvirus 4, Human / genetics. Humans. Immunoenzyme Techniques. Immunophenotyping. In Situ Hybridization. Male. Middle Aged. RNA, Messenger / genetics. Receptors, Antigen, T-Cell, alpha-beta / genetics. Receptors, Antigen, T-Cell, alpha-beta / metabolism. Receptors, Antigen, T-Cell, gamma-delta / genetics. Receptors, Antigen, T-Cell, gamma-delta / metabolism. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 20829373.001).
  • [ISSN] 1528-0020
  • [Journal-full-title] Blood
  • [ISO-abbreviation] Blood
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Messenger; 0 / Receptors, Antigen, T-Cell, alpha-beta; 0 / Receptors, Antigen, T-Cell, gamma-delta
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29. Liao JB, Chuang SS, Chen HC, Tseng HH, Wang JS, Hsieh PP: Clinicopathologic analysis of cutaneous lymphoma in taiwan: a high frequency of extranodal natural killer/t-cell lymphoma, nasal type, with an extremely poor prognosis. Arch Pathol Lab Med; 2010 Jul;134(7):996-1002
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  • [Title] Clinicopathologic analysis of cutaneous lymphoma in taiwan: a high frequency of extranodal natural killer/t-cell lymphoma, nasal type, with an extremely poor prognosis.
  • CONTEXT: Primary cutaneous lymphoma is an uncommon, extranodal lymphoma, and it is usually more indolent with a better prognosis than its histologically similar systemic counterpart is.
  • OBJECTIVES: To illustrate the clinicopathologic features of cutaneous lymphomas in Taiwan and to compare the relative frequencies of subtypes of cutaneous lymphoma among different geographic areas.
  • DESIGN: A total of 56 patients with cutaneous lymphomas were retrospectively collected and were reclassified according to the 2005 World Health Organization and the European Organization for Research and Treatment of Cancer and the 2008 World Health Organization classifications.
  • RESULTS: Thirty-one (55%) tumors were primary cutaneous lymphomas, and twenty-five (45%) tumors were secondary or concurrent cutaneous lymphomas.
  • Among primary cutaneous lymphomas, 23 cases (74%) were T-cell or natural killer-cell lymphomas, and 8 cases (26%) were B-cell lymphomas.
  • The most common types were extranodal natural killer/T-cell lymphoma, nasal type, and primary cutaneous peripheral T-cell lymphoma, unspecified (5 cases each; 16%).
  • In contrast with other primary cutaneous B-cell and T-cell lymphomas, either primary or secondary extranodal cutaneous natural killer/T-cell lymphomas, nasal type, had extremely poor prognoses (1-year overall survival, 0%).
  • CONCLUSIONS: This study showed that the frequency of subtypes of primary cutaneous lymphoma varied in different geographic areas.
  • Compared with the Western countries, there was a higher frequency of extranodal natural killer/T-cell lymphoma, nasal type, and a lower frequency of mycosis fungoides in Taiwan.
  • Extranodal natural killer/T-cell lymphoma, nasal type, also had an extremely poor prognosis compared with other lymphomas.
  • [MeSH-major] Lymphoma / epidemiology. Lymphoma / pathology. Lymphoma / physiopathology. Lymphoma, T-Cell, Cutaneous / epidemiology. Nose Neoplasms / epidemiology. Skin Neoplasms / epidemiology. Skin Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Female. Humans. Incidence. Killer Cells, Natural / pathology. Male. Middle Aged. Mycosis Fungoides / epidemiology. Prognosis. Retrospective Studies. Taiwan / epidemiology. Young Adult

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  • (PMID = 20586627.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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30. Berti E, Recalcati S, Girgenti V, Fanoni D, Venegoni L, Vezzoli P: Cutaneous extranodal NK/T-cell lymphoma: a clinicopathologic study of 5 patients with array-based comparative genomic hybridization. Blood; 2010 Jul 15;116(2):165-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cutaneous extranodal NK/T-cell lymphoma: a clinicopathologic study of 5 patients with array-based comparative genomic hybridization.
  • Extranodal natural killer/T-cell (ENK/T) lymphoma is a rare neoplasm, subcategorized into ENK/T-nasal (ENK/T-N) and ENK/T-nasal type (ENK/T-NT) lymphomas.
  • ENK/T-NT lymphoma with initial presentation in the skin is known as primary cutaneous ENK/T-NT (PC-ENK/T-NT) lymphoma.
  • The aim of this study was to investigate pathogenesis, genomic alterations, and prognosis of cutaneous ENK/T lymphomas to provide further insights into clinicopathologic features and genetic mechanism of lymphomagenesis.
  • A retrospective case study of 5 white patients affected by ENK/T lymphoma (4 PC-ENK/T-NT and 1 ENK/T-N with cutaneous involvement) was performed.
  • Genomic alterations were detected by array-based comparative genomic hybridization that showed gains of 1q, 7q and loss of 17p in the cases of PC-ENK/T-NT lymphomas and gain of 7q and loss of 9p, 12p, 12q in the case of ENK/T-N lymphoma.
  • In conclusion, ENK/T lymphoma is a very aggressive entity, and, in our cases, the exclusively cutaneous presentation was not associated with a better prognosis.
  • The results of our array comparative genomic hybridization analysis could be useful to better define the different ENK/T lymphoma subgroups with cutaneous involvement.
  • [MeSH-major] Lymphoma, T-Cell, Cutaneous / genetics. Lymphoma, T-Cell, Cutaneous / pathology. Natural Killer T-Cells / pathology. Skin Neoplasms / genetics. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Antineoplastic Agents / therapeutic use. Comparative Genomic Hybridization. Female. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 20404131.001).
  • [ISSN] 1528-0020
  • [Journal-full-title] Blood
  • [ISO-abbreviation] Blood
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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31. Gupta T, Wadasadawala T, Shet T, Jalali R, Menon H: Isolated central nervous system involvement by lymphomatoid granulomatosis in an adolescent: a case report and review of literature. Pediatr Hematol Oncol; 2010 Mar;27(2):150-9
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  • It predominantly affects lungs, skin, and brain and is characterized by multifocal, transmural, angiocentric, and angiodestructive pleomorphic lymphoid infiltrate in a perivascular distribution.
  • Lymphomatoid granulomatosis is generally considered to be a neoplastic B-cell proliferation that has traditionally been associated with poor prognosis, evolving as a progressive multisystem disease transforming into B-cell lymphoma, with a median survival of 14 to 16 months only.
  • The diagnosis of lymphomatoid granulomatosis was confirmed on light microscopy and immunohistochemistry.
  • Awareness of disease spectrum in the central nervous system may permit early diagnosis and thus allow institution of timely appropriate therapy.

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  • (PMID = 20201696.001).
  • [ISSN] 1521-0669
  • [Journal-full-title] Pediatric hematology and oncology
  • [ISO-abbreviation] Pediatr Hematol Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 23
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32. Lee EJ, Kim TW, Heo JW, Yu HG, Chung H: Natural killer/T-cell lymphoma of nasal type with intraocular involvement: case report. Eur J Ophthalmol; 2010 Jan-Feb;20(1):215-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Natural killer/T-cell lymphoma of nasal type with intraocular involvement: case report.
  • PURPOSE: To report an unusual presentation of disseminated, intraocular, extranodal natural killer/T-cell lymphoma, nasal type (NK/T-cell lymphoma), originating from nasal NK/T-cell lymphoma.
  • RESULTS: A 63-year-old woman who had been treated with systemic chemotherapy and radiotherapy for NK/T-cell lymphoma in the nasal cavity presented with vitreous haze of the right eye.
  • Despite anti-inflammatory therapy, the right eye showed poor clinical response and received diagnostic vitrectomy.
  • The vitreous specimen contained many large, pleomorphic lymphoma cells.
  • The malignant cells were positive for CD3, CD8, and granzyme B.
  • A diagnosis of T-cell lymphoma in the vitreous was made; the tumor likely originated from nasal NK/T-cell lymphoma.
  • The eye was clinically clear of malignant cells after the injections.
  • CONCLUSIONS: Vitreous infiltration without uveoretinal involvement can be an unusual manifestation of intraocular NK/T-cell lymphoma.
  • Clinician awareness of possible ocular involvement may assist in the diagnosis of disseminated NK/T-cell lymphoma.
  • [MeSH-major] Eye Neoplasms / pathology. Killer Cells, Natural. Lymphoma, T-Cell / pathology. Nose Neoplasms / pathology. Vitreous Body / pathology

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  • (PMID = 19882515.001).
  • [ISSN] 1120-6721
  • [Journal-full-title] European journal of ophthalmology
  • [ISO-abbreviation] Eur J Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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33. Tamura S, Tamura Y, Nakamoto Y, Ozawa T, Uchida K: MR imaging of histiocytic sarcoma of the canine brain. Vet Radiol Ultrasound; 2009 Mar-Apr;50(2):178-81
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  • [Title] MR imaging of histiocytic sarcoma of the canine brain.
  • Histiocytic sarcomas are characterized by proliferation and/or infiltration of neoplastic histiocytes localized to specific organs, unlike malignant histiocytosis which involves many organ systems.
  • Only a few cranial histiocytic sarcomas have been reported.
  • Here we describe four dogs that presented with neurological deficits referable to the forebrain, and were diagnosed histologically as having histiocytic sarcoma.
  • Using magnetic resonance (MR) imaging, the tumors were characterized by a T2-hyperintense and T1-isointense mass in one dog, T2- and T1-isointense extraaxial masses in two dogs, and a diffuse T2-hyperintense lesion over the left cerebral cortex in one dog.
  • MRI features in three of the four dogs were similar to that of meningioma, supported by the observation of a dural tail in two of these three dogs, and a broad base of attachment in the other.
  • Intracranial histiocytic sarcoma does not appear to have specific MR imaging features and can be confused with meningioma or encephalitis.
  • [MeSH-major] Brain Neoplasms / veterinary. Dog Diseases / diagnosis. Histiocytic Sarcoma / veterinary. Magnetic Resonance Imaging / veterinary
  • [MeSH-minor] Animals. Brain / pathology. Contrast Media / administration & dosage. Diagnosis, Differential. Dogs. Female. Male. Retrospective Studies

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  • (PMID = 19400464.001).
  • [ISSN] 1058-8183
  • [Journal-full-title] Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association
  • [ISO-abbreviation] Vet Radiol Ultrasound
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
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34. De Paoli P: Novel virally targeted therapies of EBV-associated tumors. Curr Cancer Drug Targets; 2008 Nov;8(7):591-6
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  • EBV is associated to the development of several malignancies of lymphoid and epithelial origin, including Burkitt's Lymphoma, post-transplant lymphoproliferative disorders, Hodgkin's disease, AIDS-associated lymphomas, NK/T cell lymphoma and Nasopharyngeal carcinoma.
  • EBV genes play an essential role in the development of the malignant phenotype and therefore molecules interfering with the function of these genes may represent an essential tool to treat EBV-associated malignancies.

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  • (PMID = 18991568.001).
  • [ISSN] 1873-5576
  • [Journal-full-title] Current cancer drug targets
  • [ISO-abbreviation] Curr Cancer Drug Targets
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antiviral Agents
  • [Number-of-references] 122
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35. Huang WT, Huang CC, Weng SW, Eng HL: Expression of the multidrug resistance protein MRP and the lung-resistance protein LRP in nasal NK/T cell lymphoma: further exploring the role of P53 and WT1 gene. Pathology; 2009 Feb;41(2):127-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of the multidrug resistance protein MRP and the lung-resistance protein LRP in nasal NK/T cell lymphoma: further exploring the role of P53 and WT1 gene.
  • AIMS: Nasal NK/T-cell lymphoma (NKTL) is relatively common in the adult men of Asia.
  • Many patients with nasal NKTL have poor response to therapy.
  • To investigate the expression of other multidrug resistance proteins (MDR) and possible regulatory factors in nasal NKTL, the clinical and pathological features are described.
  • METHODS: Thirty Chinese adults with nasal NKTL are presented.
  • In situ hybridisation for Epstein-Barr virus (EBV) detection, polymerase chain reaction assay for T-cell receptor gene and direct sequencing for the P53 gene were performed.
  • WT1 protein was not detected in the nasal NKTL.
  • CONCLUSION: Our study reports expression of MRP and LRP in nasal NKTL.
  • Further studies are necessary to validate the association between P53 mutation and expression of MRP and LRP in nasal NKTL.
  • [MeSH-major] Lymphoma, Extranodal NK-T-Cell / metabolism. Nose Neoplasms / metabolism. P-Glycoprotein / biosynthesis. Tumor Suppressor Protein p53 / biosynthesis. Vault Ribonucleoprotein Particles / biosynthesis. WT1 Proteins / biosynthesis

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  • (PMID = 18972317.001).
  • [ISSN] 0031-3025
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD56; 0 / P-Glycoprotein; 0 / Tumor Suppressor Protein p53; 0 / Vault Ribonucleoprotein Particles; 0 / WT1 Proteins; 0 / major vault protein
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36. Wang B, Li XQ, Ma X, Hong X, Lu H, Guo Y: Immunohistochemical expression and clinical significance of P-glycoprotein in previously untreated extranodal NK/T-cell lymphoma, nasal type. Am J Hematol; 2008 Oct;83(10):795-9
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  • [Title] Immunohistochemical expression and clinical significance of P-glycoprotein in previously untreated extranodal NK/T-cell lymphoma, nasal type.
  • Overexpression of P-glycoprotein (P-gp) has been identified by a variety of methods in NK cells and NK malignancies.
  • The aim of this study was to determine the clinical significance of P-gp in previously untreated extranodal NK/T-cell lymphoma, nasal type.
  • Our results suggest that P-gp expression is related with poor treatment outcomes of extranodal NK/T-cell lymphoma, nasal type.
  • [MeSH-major] Killer Cells, Natural / metabolism. Lymphoma, T-Cell / pathology. Nose. Nose Neoplasms / pathology. P-Glycoprotein / metabolism

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  • [Copyright] Copyright 2008 Wiley-Liss, Inc.
  • (PMID = 18756548.001).
  • [ISSN] 1096-8652
  • [Journal-full-title] American journal of hematology
  • [ISO-abbreviation] Am. J. Hematol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / P-Glycoprotein; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CHOP protocol
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37. Kakimoto K, Inoue T, Nishikawa T, Ishida K, Kawakami K, Kuramoto T, Abe Y, Morita E, Murano N, Toshina K, Murano M, Umegaki E, Egashira Y, Okuda J, Tanigawa N, Hirata I, Katsu K, Higuchi K: Primary CD56+ NK/T-cell lymphoma of the rectum accompanied with refractory ulcerative colitis. J Gastroenterol; 2008;43(7):576-80
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  • [Title] Primary CD56+ NK/T-cell lymphoma of the rectum accompanied with refractory ulcerative colitis.
  • A case of primary NK/T-cell lymphoma of the rectum accompanied with ulcerative colitis (UC) in a 73-year-old man is reported.
  • Total colonoscopy performed 4 months after resolution of refractory UC complicated by cytomegalovirus colitis showed a markedly submucosal tumor in the rectum, which was histologically diagnosed as malignant lymphoma.
  • Therefore, based on a diagnosis of localized rectal lymphoma with UC, proctocolectomy was performed.
  • Based on these findings, the patient was diagnosed with primary CD56+ NK/T-cell lymphoma of the rectum (stage IIE).
  • This is the first case report of primary rectal NK/T-cell lymphoma accompanied with UC.
  • [MeSH-major] Antigens, CD56 / analysis. Colitis, Ulcerative / complications. Lymphoma, Extranodal NK-T-Cell / complications. Rectal Neoplasms / complications

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  • (PMID = 18648746.001).
  • [ISSN] 0944-1174
  • [Journal-full-title] Journal of gastroenterology
  • [ISO-abbreviation] J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antigens, CD56
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38. Kanno H, Watabe D, Shimizu N, Sawai T: Adhesion of Epstein-Barr virus-positive natural killer cell lines to cultured endothelial cells stimulated with inflammatory cytokines. Clin Exp Immunol; 2008 Mar;151(3):519-27

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adhesion of Epstein-Barr virus-positive natural killer cell lines to cultured endothelial cells stimulated with inflammatory cytokines.
  • Furthermore, EBV-positive natural killer (NK)/T cell lymphomas often exhibit angiocentric or angiodestructive lesions.
  • These suggest an affinity of EBV-positive NK/T cells to vascular components.
  • In this study, we evaluated the expression of adhesion molecules and cytokines in EBV-positive NK lymphoma cell lines, SNK1 and SNK6, and examined the role of cytokines in the interaction between NK cell lines and endothelial cells.
  • SNKs expressed intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) at much higher levels than those in EBV-negative T cell lines.
  • SNKs produced the larger amount of tumour necrosis factor (TNF)-alpha, which caused increased expression of ICAM-1 and VCAM-1 in cultured human endothelial cells, than that from EBV-negative T cell lines.
  • Furthermore, SNKs exhibited increased adhesion to cultured endothelial cells stimulated with TNF-alpha or interleukin (IL)-1beta, and the pretreatment of cytokine-stimulated endothelial cells with anti-VCAM-1-antibodies reduced cell adhesion.
  • These indicate that the up-regulated expression of VCAM-1 on cytokine-stimulated endothelial cells would be important for the adhesion of EBV-positive NK cells and might initiate the vascular lesions.
  • [MeSH-major] Cytokines / immunology. Endothelium, Vascular / immunology. Herpesvirus 4, Human / isolation & purification. Killer Cells, Natural / virology
  • [MeSH-minor] Cell Adhesion / immunology. Endothelial Cells / immunology. Humans. Integrin alpha4beta1 / metabolism. Intercellular Adhesion Molecule-1 / immunology. Intercellular Adhesion Molecule-1 / metabolism. Lymphocyte Function-Associated Antigen-1 / metabolism. Lymphoma, T-Cell / immunology. Lymphoma, T-Cell / virology. Tumor Cells, Cultured. Vascular Cell Adhesion Molecule-1 / immunology. Vascular Cell Adhesion Molecule-1 / metabolism

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  • (PMID = 18190605.001).
  • [ISSN] 1365-2249
  • [Journal-full-title] Clinical and experimental immunology
  • [ISO-abbreviation] Clin. Exp. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cytokines; 0 / Integrin alpha4beta1; 0 / Lymphocyte Function-Associated Antigen-1; 0 / Vascular Cell Adhesion Molecule-1; 126547-89-5 / Intercellular Adhesion Molecule-1
  • [Other-IDs] NLM/ PMC2276960
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39. Colovic N, Jurisic V, Colovic M: Malignant histiocytosis with central nervous system involvement and hepatic mucinous cystadenoma in a single patient with review of the literature. J BUON; 2007 Oct-Dec;12(4):539-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant histiocytosis with central nervous system involvement and hepatic mucinous cystadenoma in a single patient with review of the literature.
  • Malignant histiocytosis is a rare neoplasm of the reticuloendothelial system characterized by neoplastic proliferation of tissue histiocytes.
  • We report a case of malignant histiocytosis in a 64-year-old female initially operated on for a mucinous cystadenoma of her liver.
  • Histology and immunohistochemistry of the lymph node and bone marrow specimens showed extensive infiltration with atypical cells, resembling malignant histiocytes (CD45, CD45RO, CD11c, CD68, lysozyme, antitrypsin and alpha1-antichymotrypsin positive; CD1, CD35, B-cell and T-cells markers negative).
  • Her condition improved, she became conscious, her headache diminished, she became mobile but skin and nodal lesions reappeared along with extensive marrow histiocytic infiltration.
  • She finally died 22 months after diagnosis.
  • [MeSH-major] Brain Neoplasms / diagnosis. Histiocytic Sarcoma / diagnosis. Neoplasms, Second Primary / diagnosis


40. Valbuena JR, Retamal Y, Bernal C, Eizuru Y, Corvalan A: Epstein-Barr virus-associated primary lymphoepitheliomalike carcinoma of the esophagus. Diagn Mol Pathol; 2007 Mar;16(1):27-31
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  • EBV genotyping analysis demonstrated infection by a novel type "i"/XhoI loss recombinant strain.
  • Although it is accepted that polymorphisms at BamHI-W1/I1 region cosegregate with polymorphisms at XhoI restriction site, this novel recombinant EBV has been identified in healthy donors and in nasal NK/T-cell lymphoma.
  • To our knowledge, this is the first report that describes this recombinant type "i"/XhoI loss EBV strain in a primary LELC of the esophagus.
  • [MeSH-major] Carcinoma / diagnosis. Epstein-Barr Virus Infections / diagnosis. Esophageal Neoplasms / diagnosis. Herpesvirus 4, Human / isolation & purification

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  • (PMID = 17471155.001).
  • [ISSN] 1052-9551
  • [Journal-full-title] Diagnostic molecular pathology : the American journal of surgical pathology, part B
  • [ISO-abbreviation] Diagn. Mol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Viral; 0 / DNA, Viral; 0 / EBNA-3C, epstein-barr virus; 0 / EBV-encoded nuclear antigen 1; 0 / Epstein-Barr Virus Nuclear Antigens
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41. Han AR, Lee HR, Park BB, Hwang IG, Park S, Lee SC, Kim K, Lim HY, Ko YH, Kim SH, Kim WS: Lymphoma-associated hemophagocytic syndrome: clinical features and treatment outcome. Ann Hematol; 2007 Jul;86(7):493-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Lymphoma-associated hemophagocytic syndrome: clinical features and treatment outcome.
  • The clinical features and prognostic factor of lymphoma-associated hemophagocytic syndrome (LAHS), diagnosed according to World Health Organization classification, were investigated by reviewing the clinical records of 29 patients between September 1994 and September 2006.
  • Compared with patients with T or natural killer (NK)/T cell LAHS, patients with B cell LAHS were older (p = 0.022), were less likely to exhibit disseminated intravascular coagulation (DIC; p = 0.011), and had less direct involvement of bone marrow (p = 0.03).
  • Clinical response was achieved in 15 (65.2%) and complete remission (CR) was achieved in 4 (17%) of 23 patients who received chemotherapy.
  • Four patients received high-dose chemotherapy and autologous stem cell transplantation (A-SCT), and three of these four patients showed CR.
  • Univariate analysis showed that poor performance status (p = 0.028), T or NK/T cell lymphoma (p = 0.016), presence of jaundice (p = 0.063), the presence of DIC (p = 0.002), and poor clinical response to treatment (p < 0.001) predicted poor overall survival.
  • These data suggest that the clinical features differ significantly between B cell LAHS and T or NK/T cell LAHS.
  • Intensive treatment including high-dose chemotherapy and A-SCT should be investigated.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Lymphohistiocytosis, Hemophagocytic / complications. Lymphoma / complications
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Female. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Prognosis. Retrospective Studies

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  • (PMID = 17347847.001).
  • [ISSN] 0939-5555
  • [Journal-full-title] Annals of hematology
  • [ISO-abbreviation] Ann. Hematol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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42. Tang QL, Liu WP, Zhang WY, Yang F, He MX, Xia QJ, Li GD: [Expression of CYR61 and VEGF in extranodal nasal-type NK/T cell lymphoma and their significances]. Zhonghua Xue Ye Xue Za Zhi; 2006 Oct;27(10):661-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Expression of CYR61 and VEGF in extranodal nasal-type NK/T cell lymphoma and their significances].
  • OBJECTIVE: To investigate the expression of CYR61 and VEGF in extranodal nasal-type NK/T cell lymphoma and its significance.
  • METHODS: CYR61 mRNA and VEGF mRNA were detected by real-time fluorescence quantitative PCR method in 20 cases of extranodal nasal-type NK/T cell lymphoma.
  • CONCLUSION: In extranodal nasal-type NK/T cell lymphoma, the expression level of CYR61 and VEGF was changed and it may be of prognostic implication of
  • [MeSH-major] Immediate-Early Proteins / biosynthesis. Intercellular Signaling Peptides and Proteins / biosynthesis. Lymphoma, T-Cell / metabolism. Nose Neoplasms / metabolism. Vascular Endothelial Growth Factor A / biosynthesis
  • [MeSH-minor] Adolescent. Adult. Aged. Cysteine-Rich Protein 61. Female. Humans. Killer Cells, Natural. Male. Middle Aged. Polymerase Chain Reaction. RNA, Messenger / biosynthesis

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  • (PMID = 17343196.001).
  • [ISSN] 0253-2727
  • [Journal-full-title] Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
  • [ISO-abbreviation] Zhonghua Xue Ye Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / CYR61 protein, human; 0 / Cysteine-Rich Protein 61; 0 / Immediate-Early Proteins; 0 / Intercellular Signaling Peptides and Proteins; 0 / RNA, Messenger; 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A
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43. Makarov NA, Gorfinkel' AN: [Malignant histocytosis]. Klin Med (Mosk); 2006;84(12):60-1

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Malignant histocytosis].
  • A case of malignant histiocytosis, a rare disease belonging to the group ofmacrophageal leucoses, was analyzed.
  • Specific clinical symptoms including fever, hepatosplenomegalia, and hematological changes, were noted.
  • The authors adduce the stages of diagnostic search from the onset of the disease to the moment the diagnosis was made, and outline the scope of disease included into differential diagnostics.
  • [MeSH-major] Histiocytic Sarcoma / pathology. Liver / pathology
  • [MeSH-minor] Adult. Biopsy / methods. Fatal Outcome. Humans. Laparoscopy. Male. Severity of Illness Index

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  • (PMID = 17294888.001).
  • [ISSN] 0023-2149
  • [Journal-full-title] Klinicheskaia meditsina
  • [ISO-abbreviation] Klin Med (Mosk)
  • [Language] rus
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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44. Wang WH, Li YX, Lin C, Liu XF, Yu ZH, Song YW, Zhang XY, Fu M, Jin J, Wang SL, Liu YP: [Expression profile of nasal NK/T cell lymphoma by cDNA microarray]. Zhonghua Zhong Liu Za Zhi; 2006 Jul;28(7):518-22
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  • [Title] [Expression profile of nasal NK/T cell lymphoma by cDNA microarray].
  • OBJECTIVE: To investigate the changes of gene expression profile in nasal NK/T cell lymphoma.
  • METHODS: Total RNA was extracted from the fresh nasal NK/T cell lymphoma tissue and normal lymph node.
  • A total of 365 (8.9%) genes was found to be differentially expressed by a factor of twofold or greater in both of two identical cDNA microarrays, which included oncogenes, tumor supressor genes, cell cycle regulators, apoptotic and antiapoptotic factors, DNA transcription factors, DNA repair and recombination factors, signal transduction genes, protein translation genes, as well as a large number of metabolic genes.
  • CONCLUSION: This study demonstrates that many different kinds of genes are possibly involved in the initiation and progression of nasal NK/T lymphoma. cDNA microarray technique is useful in screening cancer gene expression for nasal NK/T lymphoma.
  • [MeSH-major] Gene Expression Profiling. Killer Cells, Natural / metabolism. Lymphoma, T-Cell / genetics. Nose Neoplasms / genetics. Oligonucleotide Array Sequence Analysis / methods
  • [MeSH-minor] Antigens, CD20 / genetics. Chemokine CXCL9 / genetics. Gene Expression Regulation, Neoplastic. Humans. Lymph Nodes / metabolism. Lymph Nodes / pathology. Receptors, Immunologic / genetics. Receptors, Natural Killer Cell

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  • (PMID = 17147117.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD20; 0 / CXCL9 protein, human; 0 / Chemokine CXCL9; 0 / Receptors, Immunologic; 0 / Receptors, Natural Killer Cell
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45. Stokkermans-Dubois J, Jouary T, Vergier B, Delaunay MM, Taieb A: A case of primary cutaneous nasal type NK/T-cell lymphoma and review of the literature. Dermatology; 2006;213(4):345-9
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  • [Title] A case of primary cutaneous nasal type NK/T-cell lymphoma and review of the literature.
  • INTRODUCTION: Cutaneous T-cell lymphoma subtypes are now better identified thanks to progress in immunohistochemistry.
  • This article describes a new case of primary cutaneous natural killer/T-cell lymphoma of nasal type (NKTL-NT) and reviews 18 other cases of this rare neoplasm.
  • A comprehensive workup including CT scan and bone marrow biopsy was negative and a diagnosis of NKTL-NT with a primary cutaneous involvement was made.
  • DISCUSSION: After reviewing 18 other cases of primary cutaneous NKTL-NT, we conclude that the prognosis of these lymphomas is usually poor.
  • [MeSH-major] Killer Cells, Natural / pathology. Lymphoma, T-Cell, Cutaneous / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged. Antigens, CD45 / analysis. Antigens, CD56 / analysis. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Follow-Up Studies. Humans. Leg. Lymphedema / diagnosis. Male

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  • [Copyright] Copyright (c) 2006 S. Karger AG, Basel.
  • (PMID = 17135744.001).
  • [ISSN] 1018-8665
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Antigens, CD56; EC 3.1.3.48 / Antigens, CD45
  • [Number-of-references] 12
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46. Soller JT, Murua Escobar H, Janssen M, Fork M, Bullerdiek J, Nolte I: Cytokine genes single nucleotide polymorphism (SNP) screening analyses in canine malignant histiocytosis. Anticancer Res; 2006 Sep-Oct;26(5A):3417-20

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytokine genes single nucleotide polymorphism (SNP) screening analyses in canine malignant histiocytosis.
  • In humans, malignant histiocytosis is a tumour-like disease characterised by increasing proliferation of macrophages and reinforced degradation of erythrocytes.
  • Histological and cytological findings have proposed an important role of aberrant expression of cytokines in histiocytosis.
  • Due to the fact that Bernese Mountain Dogs (BMD) show a predisposition for spontaneously developing malignant histiocytosis, these dogs could possibly be used as a genetic model organism to elucidate the mechanisms of human malignant histiocytosis.
  • SNP screening in canine cytokine transcripts for malignant histiocytosis has not been carried out before.
  • [MeSH-major] Histiocytic Sarcoma / genetics. Interleukin-1alpha / genetics. Interleukin-1beta / genetics. Mutation, Missense / genetics. Polymorphism, Single Nucleotide / genetics. Tumor Necrosis Factor-alpha / genetics

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  • (PMID = 17094461.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / DNA, Complementary; 0 / Interleukin-1alpha; 0 / Interleukin-1beta; 0 / RNA, Messenger; 0 / Tumor Necrosis Factor-alpha
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47. Aozasa K: Pyothorax-associated lymphoma. J Clin Exp Hematop; 2006 Mar;46(1):5-10
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  • [Title] Pyothorax-associated lymphoma.
  • In Japan, EBV positive rate in immunocompetent patients with nodal lymphomas is less than 10% in B-cell and 20-50% in T cell lymphoma.
  • Among extranodal lymphomas, EBV positive rate is higher in pyothorax-associated lymphoma (PAL), nasal NK/T-cell lymphoma, and adrenal lymphoma.
  • PAL is non-Hodgkin's lymphoma that develops from chronic pyothorax resulted from artificial pneumothorax for the treatment of lung tuberculosis or tuberculous pleuritis.
  • [MeSH-major] Empyema, Pleural / complications. Lymphoma, B-Cell / etiology. Lymphoma, T-Cell / etiology. Nose Neoplasms / etiology. Pleural Neoplasms / etiology

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  • (PMID = 17058803.001).
  • [ISSN] 1346-4280
  • [Journal-full-title] Journal of clinical and experimental hematopathology : JCEH
  • [ISO-abbreviation] J Clin Exp Hematop
  • [Language] eng
  • [Publication-type] Historical Article; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 45
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48. Dias Pereira P, Santos M, Montenegro L, Faustino AM: A femorotibial joint swelling with popliteal lymph node enlargement in a Rottweiler. Vet Clin Pathol; 2006 Sep;35(3):335-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Histologic evaluation of the surgically-excised lymph node revealed a neoplastic proliferation of histiocytic cells, with marked pleomorphism; occasional cells were erythrophagocytic.
  • Histologic findings were consistent with malignant histiocytosis.
  • Necropsy examination confirmed the diagnosis of malignant histiocytosis with systemic involvement affecting most organs examined.
  • This case of malignant histiocytosis case had an atypical clinical presentation, mimicking a musculoskeletal disorder.
  • It underlines the importance of cytology as a simple, inexpensive, rapid and noninvasive complementary exam in routine clinical practice that can permit early diagnosis of the disease and timely selection of the most adequate therapy.

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  • (PMID = 16967421.001).
  • [ISSN] 0275-6382
  • [Journal-full-title] Veterinary clinical pathology
  • [ISO-abbreviation] Vet Clin Pathol
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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49. Lee KW, Yun T, Kim DW, Im SA, Kim TY, Yoon SS, Heo DS, Bang YJ, Park S, Kim BK, Kim NK: First-line ifosfamide, methotrexate, etoposide and prednisolone chemotherapy +/- radiotherapy is active in stage I/II extranodal NK/T-cell lymphoma. Leuk Lymphoma; 2006 Jul;47(7):1274-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] First-line ifosfamide, methotrexate, etoposide and prednisolone chemotherapy +/- radiotherapy is active in stage I/II extranodal NK/T-cell lymphoma.
  • Although most patients diagnosed with extranodal NK/T-cell lymphoma (NTCL) have localized disease, radiotherapy alone is unsatisfactory because of frequent systemic failure and conventional doxorubicin-based chemotherapy has low efficacy.
  • Sixteen patients (group A) had nasal or upper aerodigestive tract localization (stage I/II) and 10 (group B) had extranasal or disseminated disease.
  • IMEP regimen was active in NTCL patients with nasal or upper aerodigestive tract localization.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Etoposide / administration & dosage. Ifosfamide / administration & dosage. Lymphoma, T-Cell / drug therapy. Lymphoma, T-Cell / radiotherapy. Methotrexate / administration & dosage. Prednisolone / administration & dosage
  • [MeSH-minor] Adult. Aged. Combined Modality Therapy. Disease-Free Survival. Female. Humans. Male. Middle Aged. Remission Induction. Time Factors. Treatment Outcome

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  • (PMID = 16923557.001).
  • [ISSN] 1042-8194
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 6PLQ3CP4P3 / Etoposide; 9PHQ9Y1OLM / Prednisolone; UM20QQM95Y / Ifosfamide; YL5FZ2Y5U1 / Methotrexate
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50. Zimmerman K, Almy F, Carter L, Higgins M, Rossmeisl J, Inzana K, Duncan R: Cerebrospinal fluid from a 10-year-old dog with a single seizure episode. Vet Clin Pathol; 2006 Mar;35(1):127-31
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  • A cerebrospinal fluid sample collected from the cerebellomedullary cistern of a 10-year-old Shetland Sheepdog with a recent history of seizures was submitted for fluid analysis and cytologic examination.
  • Key findings included a total nucleated cell count of 520/microL (reference interval 0-5 cells/microL), with a predominance of mononuclear cells, a protein concentration of 51.8 mg/dL (reference interval 0-35 mg/dL), and a glucose concentration of 44.7 mg/dL (reference interval 52-105 mg/dL).
  • The cytologic interpretation was marked, monocytoid-rich, mixed cell pleocytosis with cellular atypia worrisome for neoplasia.
  • In addition to histiocytic neoplasia, differentials included granulomatous meningoencephalomyelitis, necrotizing meningoencephalitis, and granulomatous inflammation.
  • Histologically, the mass was composed of large, bizarre histiocytic cells with multinucleated forms and numerous mitotic figures.
  • Using immunochemistry on cytologic and histologic samples, the pleomorphic histiocytic cells were positive for CD1c, CD11ad, CD45, lysozyme, and vimentin, and were negative for CD3, CD4, CD79a, CD90, and pancytokeratin.
  • These findings supported a diagnosis of primary CNS malignant histiocytosis of dendritic antigen-presenting cell (CD1c+) origin.
  • To our knowledge, this is only the third reported case of primary CNS histiocytic sarcoma in dogs, and the first to demonstrate strong immunochemical evidence for dendritic antigen-presenting cell origin.

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  • (PMID = 16511805.001).
  • [ISSN] 0275-6382
  • [Journal-full-title] Veterinary clinical pathology
  • [ISO-abbreviation] Vet Clin Pathol
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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51. Pagano L, Gallamini A, Trapè G, Fianchi L, Mattei D, Todeschini G, Spadea A, Cinieri S, Iannitto E, Martelli M, Nosari A, Bona ED, Tosti ME, Petti MC, Falcucci P, Montanaro M, Pulsoni A, Larocca LM, Leone G, Intergruppo Italiano Linfomi: NK/T-cell lymphomas 'nasal type': an Italian multicentric retrospective survey. Ann Oncol; 2006 May;17(5):794-800
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] NK/T-cell lymphomas 'nasal type': an Italian multicentric retrospective survey.
  • OBJECTIVE: To evaluate the clinical characteristics and outcome of NK/T-cell lymphoma 'nasal type' developed in Italian patients.
  • PATIENTS: Between 1997 and 2004, 26 new cases of NK/T-cell lymphoma 'nasal type' were diagnosed in 10 Italian Hematology institutions.
  • In 23 cases presentation at the onset was in the nasal cavity or adjacent structures, in two cases the lymphoma onset with skin lesions was followed successively by rhynopharyngeal dissemination, while the remaining case had bone marrow and lymph node involvement followed by oro-pharyngeal involvement.
  • Diagnosis was based on the finding of a NK/T-cell phenotype at the histological and immunophenotypic examination of oropharyngeal or cutaneous lesions.
  • CONCLUSION: The results of this retrospective survey confirmed that NK/T-cell lymphoma 'nasal type' is a very rare lymphoma in the Italian population, and it is characterized by a very bad prognosis.
  • More data are needed to know the epidemiology of this kind of lymphoma in Europe.

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  • (PMID = 16497823.001).
  • [ISSN] 0923-7534
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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52. Hirose Y, Masaki Y, Sawaki T, Shimoyama K, Karasawa H, Kawabata H, Fukushima T, Ogawa N, Wano Y, Umehara H: Association of Epstein-Barr virus with human immunodeficiency virus-negative peripheral T-cell lymphomas in Japan. Eur J Haematol; 2006 Feb;76(2):109-18
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  • [Title] Association of Epstein-Barr virus with human immunodeficiency virus-negative peripheral T-cell lymphomas in Japan.
  • The association of Epstein-Barr virus (EBV) with human immunodeficiency virus-negative T-cell lymphoma was examined in 68 patients using the polymerase chain reaction (PCR) with DNA obtained from formalin-fixed paraffin-embedded tissues and an in situ hybridization technique.
  • EBV-encoded RNA (EBER) was detected in 43 of 68 cases (63%) of peripheral T-cell lymphoma: in 100% (11 of 11 cases) of NK/T-cell lymphomas, 70% (14 of 20 cases) of angioimmunoblastic T-cell lymphomas (AILT) and 49% (18 of 37 cases) of other types of peripheral T-cell lymphoma.
  • The 5-yr survival rate was 28% for peripheral T-cell lymphomas overall, 0% for NK/T-cell lymphomas, 38% for AILTs and 28% for other types of peripheral T-cell lymphoma.
  • The difference in the overall survival rate between NK/T-cell lymphoma and non-NK/T-cell lymphoma was significant (P = 0.0498 by Log-rank test).
  • Among peripheral T-cell lymphoma patients overall, the group severely infected with EBV (EBER-ISH ++) had a lower 5-yr survival rate (8%) than the group slightly (EBER-ISH +) or not infected (38%; P = 0.0013).
  • [MeSH-major] HIV Seronegativity. Herpesvirus 4, Human / isolation & purification. Lymphoma, T-Cell / virology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Base Sequence. DNA Probes. Female. Humans. In Situ Hybridization. Japan. Male. Middle Aged. Paraffin Embedding. Polymerase Chain Reaction

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  • (PMID = 16405431.001).
  • [ISSN] 0902-4441
  • [Journal-full-title] European journal of haematology
  • [ISO-abbreviation] Eur. J. Haematol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / DNA Probes
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53. Nigidie A, Schneider J: Nasal NK/T-cell lymphoma causing diagnostic difficulties. Ethiop Med J; 2005 Jul;43(3):197-201
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  • [Title] Nasal NK/T-cell lymphoma causing diagnostic difficulties.
  • We present history, clinical presentation and anatomo-pathologic findings of a 24-year-old female patient with a nasal NK/T-cell lymphoma.
  • This rare tumor is characterized by its angiocentric and angiodestructive growth, which results in extensive tumor necrosis.
  • However, this necrosis is a key feature: it is the result of the capacity of neoplastic NK/T-cells to invade vessels.
  • The T-cell character of the neoplastic lymphoid has been shown by immunohistochemitry.
  • [MeSH-major] Granuloma, Lethal Midline / diagnosis. Killer Cells, Natural. Lymphoma, T-Cell / diagnosis. Nose / physiopathology. Nose Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Fatal Outcome. Female. Humans

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  • (PMID = 16370552.001).
  • [ISSN] 0014-1755
  • [Journal-full-title] Ethiopian medical journal
  • [ISO-abbreviation] Ethiop. Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Ethiopia
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54. Nagato T, Kobayashi H, Kishibe K, Takahara M, Ogino T, Ishii H, Oikawa K, Aoki N, Sato K, Kimura S, Shimizu N, Tateno M, Harabuchi Y: Expression of interleukin-9 in nasal natural killer/T-cell lymphoma cell lines and patients. Clin Cancer Res; 2005 Dec 1;11(23):8250-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of interleukin-9 in nasal natural killer/T-cell lymphoma cell lines and patients.
  • PURPOSE: Nasal natural killer (NK)/T-cell lymphoma is associated with EBV and has distinct clinical and histologic features.
  • In this study, we examined the genes expressed by SNK-6 and SNT-8 cells, which were established from nasal NK/T-cell lymphomas, and found that interleukin (IL)-9 was specifically expressed in these two cell lines.
  • Cell growth was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay.
  • RESULTS: In cDNA array, expression of IL-9 mRNA was much higher in SNK-6 and SNT-8 cells than in NK-92 cells from non-nasal NK-cell lymphoma and peripheral blood mononuclear cells from healthy volunteers.
  • Furthermore, IL-9 was specifically expressed by SNK-6 and SNT-8 cells but not by other NK-cell, NK-like T-cell, and T-cell lymphoma/leukemia cell lines.
  • An IL-9-neutralizing antibody inhibited the growth of these two cell lines, whereas recombinant human IL-9 enhanced their growth.
  • Most significantly, IL-9 was present in biopsies and sera from patients with this lymphoma.
  • CONCLUSIONS: These results suggest that IL-9 plays an important role in nasal NK/T-cell lymphoma possibly via an autocrine mechanism.
  • [MeSH-major] Gene Expression Regulation, Neoplastic / physiology. Interleukin-9 / genetics. Killer Cells, Natural / pathology. Lymphoma, T-Cell / genetics. Nose Neoplasms / genetics

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  • (PMID = 16322282.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / IL9R protein, human; 0 / Interleukin-9; 0 / RNA, Messenger; 0 / Receptors, Interleukin; 0 / Receptors, Interleukin-9
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55. Vega F, Lin P, Medeiros LJ: Extranodal lymphomas of the head and neck. Ann Diagn Pathol; 2005 Dec;9(6):340-50
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  • [Title] Extranodal lymphomas of the head and neck.
  • Malignant lymphomas represent approximately 5% of all malignant neoplasms of the head and neck and may involve nodal or extranodal sites.
  • Nodal head and neck lymphomas are similar to other nodal sites and are not further reviewed here.
  • The head and neck region is the second most frequent anatomical site of extranodal lymphomas (after the gastrointestinal tract).
  • Most are non-Hodgkin's lymphomas of B-cell lineage, and overall diffuse large B-cell lymphoma is the most common type.
  • Hodgkin's lymphoma rarely occurs in extranodal sites.
  • Other hematologic neoplasms that commonly involve extranodal sites of the head and neck are also discussed.
  • In this review, we begin by discussing lymphomas involving the head and neck according to anatomical site.
  • Then we discuss specifically the pathological findings of extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue, plasmablastic lymphoma, extramedullary plasmacytoma, and extranodal natural killer/T-cell lymphoma of nasal type.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Lymphoma / pathology
  • [MeSH-minor] Humans. Killer Cells, Natural. Lymphoma, B-Cell / pathology. Lymphoma, B-Cell, Marginal Zone / pathology. Lymphoma, T-Cell / pathology. Plasmacytoma / pathology

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  • (PMID = 16308165.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 79
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56. Park CK, Oh YH: Expression of p63 in reactive hyperplasias and malignant lymphomas. J Korean Med Sci; 2005 Oct;20(5):752-8
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  • [Title] Expression of p63 in reactive hyperplasias and malignant lymphomas.
  • To obtain new insights into the role of p63 in malignant lymphomas (MLs), immunohistochemical staining for p63 and p53 was performed in 126 cases of MLs. p63 was expressed in 38 cases of MLs (30.2%) including 32/61 cases (52.5%) of diffuse large B-cell lymphoma (DLBCL), 1/8 cases (12.5%) of precursor T-lymphoblastic lymphoma (T-LBL), 4/14 cases (28.6%) of follicular lymphoma, 1/6 cases (16.7%) of T/NK cell lymphoma.
  • Among p63 positive cases, p63 was strongly expressed in 15/32 cases of DLBCL and 1/1 case of T-LBL. p63 was not expressed in mantle cell lymphomas, peripheral T-cell lymphomas, marginal zone B-cell lymphomas, plasma cell myelomas and Hodgkin's lymphomas. p63 was coexpressed with p53 in 18/38 p63 positive cases in which only 4 cases were strongly coexpressed.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Lymphoma / metabolism. Lymphoma / mortality. Membrane Proteins / metabolism. Pseudolymphoma / metabolism. Pseudolymphoma / mortality. Risk Assessment / methods

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  • (PMID = 16224147.001).
  • [ISSN] 1011-8934
  • [Journal-full-title] Journal of Korean medical science
  • [ISO-abbreviation] J. Korean Med. Sci.
  • [Language] eng
  • [Publication-type] Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CKAP4 protein, human; 0 / Membrane Proteins
  • [Other-IDs] NLM/ PMC2779270
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57. Lee J, Park YH, Kim WS, Lee SS, Ryoo BY, Yang SH, Park KW, Kang JH, Park JO, Lee SH, Kim K, Jung CW, Park YS, Im YH, Kang WK, Lee MH, Ko YH, Ahn YC, Park K: Extranodal nasal type NK/T-cell lymphoma: elucidating clinical prognostic factors for risk-based stratification of therapy. Eur J Cancer; 2005 Jul;41(10):1402-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extranodal nasal type NK/T-cell lymphoma: elucidating clinical prognostic factors for risk-based stratification of therapy.
  • The purpose of this study was to define distinctive clinical features of "nasal" and "nasal-type" NK/T cell lymphomas by assessing prognostic factors.
  • The anatomic definition of extranasal NK/T cell lymphoma has been vague resulting in variable definitions of extranasal sites by different groups.
  • We analysed the clinical behavior of 90 NK/T cell lymphoma patients and attempted to elucidate the prognostic factors for risk-based stratification of therapy.
  • We observed no significant difference between "nasal" and "nasal-type" NK/T cell lymphomas in regards to clinical features and survival using the conventional anatomic classification.
  • We suggest the categorisation of the two subtypes of NK/T cell lymphoma as follows: UNKTL (upper aerodigestive tract NK/T cell lymphoma) including all lymphomas confined to nasal cavity, nasopharynx, and the upper aerodigestive tract and EUNKTL (extra-upper aerodigestive tract NK/T cell lymphoma) group to include all sites other than the UNKTL group.
  • The EUNKTL group in this study had advanced stage at diagnosis, higher LDH, higher IPI score, poorer performance and inferior response to the anthracycline-based chemotherapy with statistical significance.
  • [MeSH-major] Killer Cells, Natural / pathology. Lymphoma, T-Cell / pathology. Nose Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Female. Humans. Male. Middle Aged. Prognosis. Retrospective Studies. Risk Assessment. Risk Factors. Survival Analysis

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  • (PMID = 15963893.001).
  • [ISSN] 0959-8049
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
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58. Nagatani M, Yamakawa S, Ando R, Edamoto H, Saito T, Tamura K: Highly invasive intracranial malignant schwannoma in a rat. J Toxicol Pathol; 2009 Jun;22(2):139-42

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  • [Title] Highly invasive intracranial malignant schwannoma in a rat.
  • A highly invasive intracranial malignant schwannoma containing several masses was detected in a 28-week-old male Crl:CD(SD) rat.
  • Macroscopically, 3 masses were noted in the cranial cavity; one was present at the bottom of the cranial cavity and involved the trigeminal nerve, and the other two were in the parietal bone.
  • In the brain, the tumor cells infiltrated diffusely into the leptomeningeal and perivascular spaces and parenchyma, in which the tumor cell morphology and invasive pattern closely resembled those of malignant astrocytoma and malignant reticulosis.
  • Electron microscopically, a single basal lamina layer and short intricate cell processes were confirmed in the tumor cells.
  • From these results, the present tumor was diagnosed as a malignant schwannoma arising in the cranial cavity, probably originating from the trigeminal nerve.
  • The present tumor is considered to be a relatively unique malignant schwannoma based on its growth and invasion patterns.

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  • (PMID = 22271987.001).
  • [ISSN] 0914-9198
  • [Journal-full-title] Journal of toxicologic pathology
  • [ISO-abbreviation] J Toxicol Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Other-IDs] NLM/ PMC3246059
  • [Keywords] NOTNLM ; cranial cavity / malignant schwannoma / rat / spontaneous
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59. Liang Q, Ye ZY, Su ZL, Lin HL, Shao CK, Lin SX, Rao HL, Mei KY, Zhao T, Liu YH, Luo DL, Zhu MG, Chen SH, Lin TY: [Clinicopathologic study of 963 cases of mature T-cell and natural killer/T-cell lymphoma with respect to 2008 WHO classification of lymphoid neoplasms]. Zhonghua Bing Li Xue Za Zhi; 2010 May;39(5):291-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinicopathologic study of 963 cases of mature T-cell and natural killer/T-cell lymphoma with respect to 2008 WHO classification of lymphoid neoplasms].
  • OBJECTIVE: To study the clinicopathologic features of various types of mature T-cell and natural killer (NK)/T-cell lymphoma in Guangdong, China, with respect to the 2008 WHO classification of lymphoid neoplasms.
  • METHODS: Eleven hundred and thirty-seven (1137) cases of mature T-cell or NK/T-cell lymphoma diagnosed during the period from 2002 to 2006 in Guangzhou area were retrieved.
  • The clinical data, histologic features and immunohistochemical findings were reviewed by a panel of experienced hematopathologists.
  • The cases were re-classified according to the 2008 WHO classification of lymphoid neoplasms.
  • RESULTS: Nine hundred and sixty-three (963) cases fulfilled the diagnostic criteria of mature T-cell or NK/T-cell lymphoma and accounted for 20.1% of all cases of lymphoma encountered during the same period (963/4801).
  • A predominance of extranodal involvement was noted in 644 cases (66.9%), while 319 cases (33.1%) showed mainly nodal disease.
  • The prevalence of various lymphoma subtypes was as follows: peripheral T-cell lymphoma, unspecified (PTCL, NOS) 293 cases (30.4%), extranodal NK/T-cell lymphoma, nasal type 281 cases (29.2%), anaplastic large cell lymphoma (ALCL) 198 cases (20.6%), and angioimmunoblastic T-cell lymphoma (AILT) 46 cases (4.8%).
  • The median age of the patients was 44 years, with the peak age of PTCL, NOS, extranodal NK/T-cell lymphoma, nasal type and AILT being 55 to 64 years, 25 to 54 years and 65 to 74 years, respectively.
  • CONCLUSIONS: Extranodal lesions predominate in mature T-cell and NK/T-cell lymphomas occurring in Guangzhou area.
  • The most common subtype was PTCL, NOS, followed by extranodal NK/T-cell lymphoma, nasal type, ALCL and AILT.
  • The relatively frequent occurrence of extranodal NK/T-cell lymphoma, nasal type in Guangdong area is likely associated with the high incidence of Epstein-Barr virus infection there.
  • [MeSH-major] Lymphoma, Extranodal NK-T-Cell / pathology. Lymphoma, Large-Cell, Anaplastic / pathology. Lymphoma, T-Cell / classification. Lymphoma, T-Cell / pathology. Lymphoma, T-Cell, Peripheral / pathology
  • [MeSH-minor] Adolescent. Adult. Age Factors. Aged. Aged, 80 and over. Child. Child, Preschool. China. Epstein-Barr Virus Infections. Female. Humans. Immunoblastic Lymphadenopathy / metabolism. Immunoblastic Lymphadenopathy / pathology. Immunoblastic Lymphadenopathy / virology. Infant. Male. Middle Aged. Protein-Tyrosine Kinases / metabolism. Receptor Protein-Tyrosine Kinases. Retrospective Studies. Sex Factors. World Health Organization. Young Adult

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  • (PMID = 20654150.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / Receptor Protein-Tyrosine Kinases; EC 2.7.10.1 / anaplastic lymphoma kinase
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60. Park S, Lee DY, Kim WS, Ko YH: Primary cutaneous Epstein-Barr virus-associated T-cell lymphoproliferative disorder-2 cases with unusual, prolonged clinical course. Am J Dermatopathol; 2010 Dec;32(8):832-6
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  • [Title] Primary cutaneous Epstein-Barr virus-associated T-cell lymphoproliferative disorder-2 cases with unusual, prolonged clinical course.
  • Hydroa vacciniforme-like lymphoma and extranodal-type natural killer (NK)/T-cell lymphoma are prototypes of Epstein-Barr virus (EBV)-associated cutaneous T- or NK-cell lymphomas.
  • Hydroa vacciniforme-like lymphoma with systemic spread and extranodal-type NK/T-cell lymphoma are characterized by aggressive clinical course.
  • We describe 2 patients with primary cutaneous EBV-associated T-cell lymphomas who did not satisfy the criteria for well-defined entities and showed unusual, prolonged clinical course.
  • The EBV genomes were found within the tumor cells, and monoclonal T-cell receptor gene rearrangement was present.
  • We suggest that these cases represent a peculiar subtype of EBV+ cutaneous T-cell lymphoma, with a tendency to localize in the skin of the extremities and has an indolent clinical course.
  • [MeSH-major] Epstein-Barr Virus Infections / virology. Herpesvirus 4, Human / isolation & purification. Lymphoma, T-Cell, Cutaneous / virology. Skin / virology. Skin Neoplasms / virology

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  • (PMID = 20595887.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD3; 0 / Antigens, CD56; 0 / Antigens, CD8; 0 / Biomarkers, Tumor; 0 / DNA, Viral; 0 / NCAM1 protein, human
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61. Chang CH, Hsu YH: Hyper-IgE syndrome with Epstein-Barr virus associated extranodal NK/T cell lymphoma of skin. Kaohsiung J Med Sci; 2010 Apr;26(4):206-10
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  • [Title] Hyper-IgE syndrome with Epstein-Barr virus associated extranodal NK/T cell lymphoma of skin.
  • Here, we report an 18-year-old woman who was frequently hospitalized since childhood because of recurrent pneumonia and urinary tract infection.
  • Multiple erythematous papules and nodules with ulceration were found on her face and right forearm.
  • A skin biopsy showed angiocentric and angiodestructive atypical lymphoid infiltration.
  • Accordingly, this indicates that Epstein-Barr virus infection may have induced the extranodal natural killer/T cell lymphoma in this patient with hyper-IgE syndrome.
  • [MeSH-major] Herpesvirus 4, Human / physiology. Job Syndrome / complications. Job Syndrome / virology. Lymphoma, Extranodal NK-T-Cell / complications. Lymphoma, Extranodal NK-T-Cell / virology. Skin Neoplasms / complications. Skin Neoplasms / virology

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  • [Copyright] Copyright 2010 Elsevier. Published by Elsevier B.V. All rights reserved.
  • (PMID = 20434102.001).
  • [ISSN] 1607-551X
  • [Journal-full-title] The Kaohsiung journal of medical sciences
  • [ISO-abbreviation] Kaohsiung J. Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
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62. Su XY, Xu X, Tang Y, Li GD: [Diagnosis of hematolymphoid malignancy by using effusion fluid cytology specimens: a study of 33 cases]. Zhonghua Bing Li Xue Za Zhi; 2009 Aug;38(8):542-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Diagnosis of hematolymphoid malignancy by using effusion fluid cytology specimens: a study of 33 cases].
  • METHODS: The cytospin preparations/smears and cell block sections of effusion cytology specimens from 33 cases of hematolymphoid malignancy were retrospectively reviewed.
  • In selected cases, in-situ hybridization for Epstein-Barr virus-encoded RNA and immunoglobulin and T-cell receptor gene rearrangement study were carried out as indicated.
  • RESULTS: There were 33 cases of hematolymphoid malignancy, including 12 cases of T-lymphoblastic leukemia/lymphoma, 16 cases of mature B cell neoplasm (including 9 cases of diffuse large B-cell lymphoma, 2 cases of Burkitt lymphoma, 2 cases of plasmacytoma/multiple myeloma, 2 cases of B-small lymphocytic leukemia/lymphoma and 1 case of mantle cell lymphoma), 3 cases of mature T or NK-cell neoplasm (including 1 case of extranodal nasal NK/T-cell lymphoma, 1 case of angioimmunoblastic T-cell lymphoma and 1 case of T-cell prolymphocytic leukemia), 1 case of myeloid sarcoma and 1 case of mast cell sarcoma.
  • Amongst the 33 cases studied, 16 represented disease relapses, including 8 cases of diffuse large B-cell lymphoma, 2 cases of plasmacytoma/multiple myeloma, 2 cases of B-small lymphocytic leukemia/lymphoma, 1 case of T-lymphoblastic leukemia/lymphoma, 1 case of angioimmunoblastic T-cell lymphoma, 1 case of mantle cell lymphoma and 1 case of mast cell sarcoma.
  • The remaining 17 cases showed serous effusion as the primary manifestation, with the diagnosis primarily made upon cytologic examination.
  • The cytologic findings seen in all the 33 cases studied were in agreement with the corresponding histologic diagnosis.
  • CONCLUSIONS: Diagnosis of hematolymphoid malignancy by effusion fluid cytology specimens is possible, especially when coupled with the clinical history, immunophenotype, in-situ hybridization and gene rearrangement study findings.
  • [MeSH-major] Ascitic Fluid / pathology. Cytodiagnosis / methods. Lymphoma, Large B-Cell, Diffuse / diagnosis. Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Burkitt Lymphoma / diagnosis. Burkitt Lymphoma / metabolism. Burkitt Lymphoma / pathology. Child. Female. Humans. Immunohistochemistry. Lymphoma, Extranodal NK-T-Cell / diagnosis. Lymphoma, Extranodal NK-T-Cell / metabolism. Lymphoma, Extranodal NK-T-Cell / pathology. Male. Middle Aged. Multiple Myeloma / diagnosis. Multiple Myeloma / metabolism. Multiple Myeloma / pathology. Plasmacytoma / diagnosis. Plasmacytoma / metabolism. Plasmacytoma / pathology. Retrospective Studies. Young Adult

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  • (PMID = 20021966.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] China
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63. Kobayashi R, Yamato K, Tanaka F, Takashima Y, Inada H, Kikuchi A, Kumagai MA, Sunami S, Nakagawa A, Fukano R, Fujita N, Mitsui T, Tsurusawa M, Mori T, Lymphoma Committee, Japanese Pediatric Leukemia/Lymphoma Study Group: Retrospective analysis of non-anaplastic peripheral T-cell lymphoma in pediatric patients in Japan. Pediatr Blood Cancer; 2010 Feb;54(2):212-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Retrospective analysis of non-anaplastic peripheral T-cell lymphoma in pediatric patients in Japan.
  • BACKGROUND: Reports of non-anaplastic peripheral T-cell lymphoma (PTCL) in pediatric patients are relatively rare.
  • RESULTS: We could analyze clinical data in 21 patients with non-anaplastic PTCL; 10 were female and 10 male.
  • There were nine patients with PTCL, not otherwise specified (PTCL-NOS); ten with extranodal NK/T-cell lymphoma, nasal type; one with angioimmunoblastic T-cell lymphoma; and one with subcutaneous panniculitis-like T-cell lymphoma.
  • In five patients, hemophagocytic syndrome (HPS) was the initial clinical feature.
  • CONCLUSIONS: Generally, the outcome results of conventional chemotherapy for high-risk PTCL are poor in adult patients.
  • However, the excellent results in our study suggest that PTCL of childhood is quite different from that of adulthood.
  • [MeSH-major] Lymphoma, T-Cell, Peripheral / epidemiology. Lymphoma, T-Cell, Peripheral / therapy
  • [MeSH-minor] Adolescent. Antineoplastic Combined Chemotherapy Protocols. Child. Child, Preschool. Combined Modality Therapy. Female. Humans. Infant. Japan / epidemiology. Male. Retrospective Studies. Stem Cell Transplantation. Survival Rate. Young Adult

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • (PMID = 19856396.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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64. Abadie J, Hédan B, Cadieu E, De Brito C, Devauchelle P, Bourgain C, Parker HG, Vaysse A, Margaritte-Jeannin P, Galibert F, Ostrander EA, André C: Epidemiology, pathology, and genetics of histiocytic sarcoma in the Bernese mountain dog breed. J Hered; 2009 Jul-Aug;100 Suppl 1:S19-27
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  • [Title] Epidemiology, pathology, and genetics of histiocytic sarcoma in the Bernese mountain dog breed.
  • Histiocytic sarcoma (HS) refers to a highly aggressive and frequently disseminated neoplastic disease belonging to the class of canine histiocytic proliferative disorders.
  • Disseminated HS (previously called malignant histiocytosis) is highly breed specific, with Bernese mountain dogs (BMDs), rottweilers, and retrievers having a high prevalence with a frequency of approximately 25% in the BMD breed.
  • We collected DNA samples and clinical information from 800 BMDs, of which 200 are affected by HS.
  • The clinical features, biochemical parameters, and pathological features have been determined.
  • The life span after diagnosis has been estimated to be 49 days.
  • [MeSH-major] Dog Diseases / epidemiology. Dog Diseases / genetics. Histiocytic Sarcoma / veterinary

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  • (PMID = 19531730.001).
  • [ISSN] 1465-7333
  • [Journal-full-title] The Journal of heredity
  • [ISO-abbreviation] J. Hered.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3139364
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65. Pfistershammer K, Petzelbauer P, Stingl G, Mastan P, Chott A, Jäger U, Skrabs C, Geusau A: Methotrexate-induced primary cutaneous diffuse large B-cell lymphoma with an 'angiocentric' histological morphology. Clin Exp Dermatol; 2010 Jan;35(1):59-62
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  • [Title] Methotrexate-induced primary cutaneous diffuse large B-cell lymphoma with an 'angiocentric' histological morphology.
  • A patient with a 25-year history of rheumatoid arthritis and a 3-year history of methotrexate treatment developed a generalized papular rash.
  • Histology revealed a nodular infiltrate composed of a mixture of pleomorphic large B cells positive for CD20, CD30 and CD79a, and of small T cells positive for CD3 and CD4.
  • The T cells had a striking angiocentric distribution, with some of the vessels exhibiting fibrinoid necrosis of the vessel wall reminiscent of lymphomatoid granulomatosis.
  • Thus, this patient was classified as having a rare form of an EBV-negative primary cutaneous T-cell-rich B-cell lymphoma in association with methotrexate treatment.
  • [MeSH-major] Antimetabolites, Antineoplastic / adverse effects. Lymphoma, Large B-Cell, Diffuse / chemically induced. Lymphoma, Large B-Cell, Diffuse / pathology. Methotrexate / adverse effects. Skin Neoplasms / chemically induced. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. B-Lymphocytes / pathology. Diagnosis, Differential. Female. Humans. Pityriasis Lichenoides / pathology. T-Lymphocytes / pathology

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  • (PMID = 19486063.001).
  • [ISSN] 1365-2230
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; YL5FZ2Y5U1 / Methotrexate
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66. Luo QL, He WM, Tang L, Liao YC, Yang YL: [Clinicopathologic observation of orbital natural killer-T cell lymphoma]. Zhonghua Yan Ke Za Zhi; 2008 Jan;44(1):42-5
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  • [Title] [Clinicopathologic observation of orbital natural killer-T cell lymphoma].
  • OBJECTIVE: To investigate clinical manifestation, diagnosis and treatment of orbital natural killer (NK)-T cell lymphoma.
  • Seven orbital NK-T cell lymphoma patients confirmed by surgical biopsies were collected during the past 22 years.
  • Skin of inner canthus and eyelids appeared red and swollen, with ulceration and cavity formation.
  • Clonal T-cell-receptor gene rearrangements of two patients showed negative results and the Epstein-Barr virus was detected.
  • CONCLUSIONS: Orbital NK-T cell lymphoma is a rare disease.
  • The characteristics of this disease include a highly aggressive clinical course, severe destruction and a poor prognosis.
  • The final diagnosis depends on HE staining, immunohistochemical staining and molecular biological examination.
  • [MeSH-major] Lymphoma, T-Cell / pathology. Natural Killer T-Cells. Orbital Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Female. Gene Rearrangement, T-Lymphocyte. Humans. Male. Middle Aged. Retrospective Studies. Young Adult

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  • (PMID = 18510242.001).
  • [ISSN] 0412-4081
  • [Journal-full-title] [Zhonghua yan ke za zhi] Chinese journal of ophthalmology
  • [ISO-abbreviation] Zhonghua Yan Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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67. Monobe H, Nakashima M, Tominaga K: Primary laryngeal natural killer/T-cell lymphoma--report of a rare case. Head Neck; 2008 Nov;30(11):1527-30

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary laryngeal natural killer/T-cell lymphoma--report of a rare case.
  • BACKGROUND: Natural killer (NK)/T-cell lymphoma involving the larynx is a rare entity, and its clinical picture has not been described.
  • Multiple biopsies over 1 year were needed to reach an accurate diagnosis of NK/T-cell lymphoma.
  • CONCLUSION: To the best of our knowledge, this is the second case of primary laryngeal NK/T-cell that illustrates its clinical picture.
  • In the early stage of the disease, this type of tumor can present as granulous tumor-like lesion without a definite destructive lesion.
  • This tumor type should be kept in mind in tumors that are difficult to diagnose, especially in Asian populations.
  • [MeSH-major] Killer Cells, Natural. Laryngeal Neoplasms / diagnosis. Lymphoma, T-Cell / diagnosis

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  • [Copyright] (c) 2008 Wiley Periodicals, Inc. Head Neck, 2008.
  • (PMID = 18302263.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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68. Gaitonde S, Attele A, Abutalib SA, Rondelli D, Lindgren V: Extranodal natural killer/t-cell lymphoma, nasal type, in a patient with a constitutional 11q terminal deletion disorder. Acta Haematol; 2007;118(1):42-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extranodal natural killer/t-cell lymphoma, nasal type, in a patient with a constitutional 11q terminal deletion disorder.
  • BACKGROUND: Most cases of constitutional 11q terminal deletion disorder are children.
  • AIM: To report the first hematologic malignancy [extranodal natural killer (NK)/T-cell lymphoma, nasal type] arising in the trachea of a patient with constitutional 11q terminal deletion disorder.
  • It is of note that this cytogenetic abnormality has not been described as a recurring abnormality in extranodal NK/T-cell lymphoma.
  • Pathologic evaluation was diagnostic of extranodal NK/T-cell lymphoma, nasal type.
  • Staging marrow was negative for lymphoma, but cytogenetic analysis revealed a constitutional deletion of chromosome 11 at band q23 [46,XY,del(11)(q23)(c)].
  • This abnormality was present in a subsequent bone marrow specimen, along with an acquired abnormality, namely an extra copy of part of the long arm of chromosome 1 translocated to the short arm of chromosome 14.
  • CONCLUSION: Patients with 11q terminal deletion disorder who reach adulthood may be predisposed to develop neoplasias by virtue of the constitutional deletion.
  • [MeSH-major] Chromosome Deletion. Chromosomes, Human, Pair 11. Lymphoma, T-Cell, Peripheral / genetics. Lymphoma, T-Cell, Peripheral / pathology. Nose Neoplasms / genetics. Nose Neoplasms / pathology
  • [MeSH-minor] Adult. Biopsy, Needle. Chromosome Aberrations. Cytogenetic Analysis. Disease Progression. Fatal Outcome. Humans. Immunohistochemistry. Killer Cells, Natural / pathology. Male. Nasal Mucosa / pathology. Severity of Illness Index

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  • [Copyright] Copyright 2007 S. Karger AG, Basel.
  • (PMID = 17476097.001).
  • [ISSN] 1421-9662
  • [Journal-full-title] Acta haematologica
  • [ISO-abbreviation] Acta Haematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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69. Sahni CS, Desai SB: Distribution and clinicopathologic characteristics of non-Hodgkin's lymphoma in India: a study of 935 cases using WHO classification of lymphoid neoplasms (2000). Leuk Lymphoma; 2007 Jan;48(1):122-33

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Distribution and clinicopathologic characteristics of non-Hodgkin's lymphoma in India: a study of 935 cases using WHO classification of lymphoid neoplasms (2000).
  • The frequency of various subtypes of non-Hodgkin's lymphoma (NHL) differs in various regions worldwide.
  • B- and T-cell NHL constituted 79.3% and 18.8% of cases.
  • Diffuse large B-cell lymphoma (DLBL) was the most common subtype (50.2%).
  • A lower frequency of follicular lymphoma, marginal zone lymphoma and mantle cell lymphoma (MCL) was noted compared to that observed in the developed countries, whereas a lower frequency of peripheral T-cell lymphoma - not otherwise specified (PTCL-NOS) and extranodal NK/T-cell lymphoma was seen compared to that in the other Asian countries.
  • A higher frequency of DLBL and precursor T-lymphoblastic leukemia/lymphoma was noted.
  • Extranodal and bone marrow involvement in MCL and PTCL-NOS was less frequent.
  • Null/T-cell anaplastic large cell lymphoma presented in the older age.
  • [MeSH-major] Lymphoma, Non-Hodgkin / epidemiology. World Health Organization
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Cross-Sectional Studies. Female. Humans. India / epidemiology. Leukemia, Lymphoid / classification. Leukemia, Lymphoid / pathology. Male. Middle Aged. Neoplasm Staging. Retrospective Studies

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  • (PMID = 17325856.001).
  • [ISSN] 1042-8194
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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70. Boudova L, Kazakov DV, Jindra P, Sima R, Vanecek T, Kuntscher V, Vera V, Bouda J, Michal M: Primary cutaneous histiocyte and neutrophil-rich CD30+ and CD56+ anaplastic large-cell lymphoma with prominent angioinvasion and nerve involvement in the forehead and scalp of an immunocompetent woman. J Cutan Pathol; 2006 Aug;33(8):584-9
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  • [Title] Primary cutaneous histiocyte and neutrophil-rich CD30+ and CD56+ anaplastic large-cell lymphoma with prominent angioinvasion and nerve involvement in the forehead and scalp of an immunocompetent woman.
  • BACKGROUND: Cutaneous lymphomas co-expressing CD56 and CD30 are very rare.
  • They share a clinicopathological overlap with natural killer- (NK)/T-cell lymphomas and anaplastic large-cell lymphomas (ALCLs), two entities with widely disparate clinical behavior.
  • The partially ulcerated and pus-secreting tumor involved the forehead and scalp and was assessed as clinical stage IAE.
  • Additionally, high-dose chemotherapy with autologous peripheral blood stem-cell transplantation was administered as a consolidation of complete remission, in which she has remained for 6 years.
  • CONCLUSIONS: This is the first CD30+ and CD56+ primary skin lymphoma to be reported on the head.
  • The presented case carries a remarkable combination of clinicopathological features of PCALCL and NK-/T-cell lymphoma.
  • [MeSH-major] Antigens, CD30 / analysis. Antigens, CD56 / analysis. Lymphoma, Large B-Cell, Diffuse / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Female. Forehead. Head and Neck Neoplasms / blood supply. Head and Neck Neoplasms / drug therapy. Head and Neck Neoplasms / immunology. Head and Neck Neoplasms / pathology. Histiocytes / cytology. Humans. Middle Aged. Neutrophils / cytology. Scalp / blood supply. Scalp / drug effects. Scalp / innervation. Scalp / pathology. Stem Cell Transplantation

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  • (PMID = 16919035.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD30; 0 / Antigens, CD56
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71. Neumann S: [Effects of different liver diseases on the platelet count in dogs]. Dtsch Tierarztl Wochenschr; 2006 Jun;113(6):224-7
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  • The results showed, that dogs with liver degeneration have thrombocytosis in 41% of the cases and a group of dogs with liver tumours (malignant histiocytosis, hepatoma, malignant lymphoma anaplastic sarcoma, cholangiocarcinoma, hepatocellular carcinoma) had thrombocytopenia in 50% of the cases.
  • The statistical comparison of our patients with liver disease and a control group of healthy dogs showed significantly higher platelet counts in cases of liver degeneration (p < 0.0001) and significantly lower platelet counts in cases of liver tumour (p < 0.001).

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  • (PMID = 16856607.001).
  • [ISSN] 0341-6593
  • [Journal-full-title] DTW. Deutsche tierärztliche Wochenschrift
  • [ISO-abbreviation] DTW. Dtsch. Tierarztl. Wochenschr.
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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72. Assanasen T, Wannakrairot P, Keelawat S, Ruangvejvorachai P, Pramprayoon N: Extranodal malignant lymphoma of the upper aerodigestive tract: prevalence of Epstien-Barr virus (EBV) infection in King Chulalongkorn Memorial Hospital. J Med Assoc Thai; 2005 Sep;88 Suppl 4:S266-73
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extranodal malignant lymphoma of the upper aerodigestive tract: prevalence of Epstien-Barr virus (EBV) infection in King Chulalongkorn Memorial Hospital.
  • Malignant lymphomas arising in this site may be associated with EBV.
  • OBJECTIVES: To determine the prevalence of EBV infection in extranodal malignant lymphomas of the upper aerodigestive tract.
  • MATERIAL AND METHOD: The expression of EBV mRNAs (EBERs) of malignant lymphoma was studied by means of in situ hybridization in formalin-fixed, paraffin-embedded specimens.
  • Ten of 42 cases (23.81%) expressed EBER transcripts and were extranodal NK/T-cell lymphomas, nasal type (7 cases), plasmablastic lymphomas (2 cases) and diffuse large B-cell lymphoma (1 case).
  • Three of 4 cases (75%) of known HIV-seropositive cases were EBV-positive (2 plasmablastic lymphomas and 1 diffuse large B-cell lymphoma).
  • CONCLUSION: In the upper aerodigestive tract, EBV was present in some but not all malignant lymphoma.
  • It was associated with extranodal NK/T-cell lymphoma, nasal type and B-cell lymphoma arising in HIV-infected patients, but it was not found in B-cell lymphoma arising in immunocompetent patients.
  • [MeSH-major] Epstein-Barr Virus Infections / epidemiology. Herpesvirus 4, Human / isolation & purification. Lymphoma / virology. Lymphoma, B-Cell / virology. Lymphoma, T-Cell / virology. Respiratory System / virology. Upper Gastrointestinal Tract / virology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Disease Reservoirs. Female. Humans. In Situ Hybridization. Male. Middle Aged. Prevalence. Risk Factors. Thailand / epidemiology

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  • (PMID = 16623040.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Thailand
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73. Yao B, Li YX, Fang H, Jin J, Liu XF, Yu ZH: [Prognostic factors of primary non-Hodgkin's lymphoma of the nasal cavity--a report of 129 cases]. Ai Zheng; 2006 Apr;25(4):465-70
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  • [Title] [Prognostic factors of primary non-Hodgkin's lymphoma of the nasal cavity--a report of 129 cases].
  • BACKGROUND & OBJECTIVE: The prognosis of primary non-Hodgkin's lymphoma (NHL) of the nasal cavity was poor, and the distant metastasis and local relapse rates are high.
  • METHODS: Clinical data of 129 patients with pathologically confirmed nasal NHL, treated from Jan.
  • Of the 129 patients, 116 were diagnosed as nasal NK/T-cell lymphoma.
  • Thirty-eight patients developed progression or relapse, with distant extranodal dissemination (78.9%) as the primary pattern of failure.
  • CONCLUSIONS: CR rate after treatment is an important prognostic factor of nasal NHL.
  • Distant metastasis is the main failure pattern of nasal NHL.
  • [MeSH-major] Lymphoma, Extranodal NK-T-Cell / therapy. Lymphoma, Non-Hodgkin / therapy. Nasal Cavity. Nose Neoplasms / therapy
  • [MeSH-minor] Adolescent. Adult. Aged, 80 and over. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Child. Combined Modality Therapy. Cyclophosphamide / therapeutic use. Disease-Free Survival. Doxorubicin / therapeutic use. Female. Follow-Up Studies. Humans. Lymphatic Metastasis. Lymphoma, B-Cell / drug therapy. Lymphoma, B-Cell / pathology. Lymphoma, B-Cell / radiotherapy. Lymphoma, B-Cell / therapy. Male. Middle Aged. Neoplasm Recurrence, Local. Neoplasm Staging. Prednisone / therapeutic use. Remission Induction. Survival Rate. Vincristine / therapeutic use. Young Adult

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  • (PMID = 16613682.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CHOP protocol
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74. Choi YL, Park JH, Kim WS, Lee DY, Lee JH, Yang JM, Lee ES: Aggressive NK-cell leukaemia associated with reactive haemophagocytic syndrome. Clin Exp Dermatol; 2006 Jan;31(1):83-5
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  • [Title] Aggressive NK-cell leukaemia associated with reactive haemophagocytic syndrome.
  • We report a case of aggressive NK-cell leukaemia associated with reactive haemophagocytic syndrome in a 29-year-old Korean woman who had several small purpuric patches on both thighs.
  • The bone marrow examination showed diffuse histiocytic proliferation with several haemophagocytic macrophages, suggesting an associated reactive haemophagocytic syndrome.
  • Skin biopsy from her thigh lesion demonstrated atypical CD56+ lymphoid cellular infiltrates with angiocentric pattern, and in situ hybridization test for Epstein-Barr virus was positive.
  • [MeSH-major] Killer Cells, Natural / immunology. Leukemia / immunology. Lymphohistiocytosis, Hemophagocytic / immunology. Lymphoma, T-Cell, Cutaneous / immunology
  • [MeSH-minor] Adult. Antigens, CD / analysis. Bone Marrow Cells / immunology. Fatal Outcome. Female. Humans. Skin / immunology. Skin / pathology. Thigh

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  • (PMID = 16309492.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD
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75. Drut R, Drut RM: Angiocentric immunoproliferative lesion and angiocentric lymphoma of lymph node in children. A report of two cases. J Clin Pathol; 2005 May;58(5):550-2
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  • [Title] Angiocentric immunoproliferative lesion and angiocentric lymphoma of lymph node in children. A report of two cases.
  • AIM: To report two examples of an angiocentric immunoproliferative lesion (AIL) and angiocentric angiodestructive lymphoma (AL) presenting in lymph nodes in children.
  • Most commonly involving extranodal sites, AIL/AL rarely presents in the spleen and lymph nodes.
  • METHODS/RESULTS: Case 1 presented as a cervical lymphadenopathy in a 3 year old girl being treated for pre-B cell acute lymphoblastic leukaemia.
  • Histological and immunohistochemistry studies revealed an Epstein-Barr virus positive (EBV+), large B cell (CD20 and CD30+) AIL with large areas of necrosis, the whole resembling lymphomatoid granulomatosis.
  • Histology and immunohistochemistry revealed an EBV-, large T cell (CD45RO, CD56, and CD30+) AL, presenting the features of so called angiocentric T cell/natural killer cell lymphoma, nasal type.
  • CONCLUSIONS: The term AIL/AL refers to a heterogeneous group of conditions not unique to a particular type of lymphoid cell.
  • These lesions are easily recognised by the histopathologist because of their extremely unusual angiocentric pattern.
  • [MeSH-major] Immunoproliferative Disorders / pathology. Lymph Nodes / pathology. Lymphatic Diseases / pathology. Lymphoma, T-Cell / pathology

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  • (PMID = 15858132.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1770650
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76. Lee SR, Park EK, Won NH, Kim BS: Esophageal involvement by extranodal natural killer T cell lymphoma, nasal type, mimicking Ebstein Barr viral esophagitis in a tonsillar lymphoma patient undergoing chemoradiation therapy. Asia Pac J Clin Oncol; 2010 Sep;6(3):149-54
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  • [Title] Esophageal involvement by extranodal natural killer T cell lymphoma, nasal type, mimicking Ebstein Barr viral esophagitis in a tonsillar lymphoma patient undergoing chemoradiation therapy.
  • Esophageal involvement by extranodal natural killer (NK)/T cell lymphoma, nasal type, is rare.
  • It is important to note, however, that benign conditions may mask esophageal involvement by lymphoma.
  • Until now, there has been no report documenting esophageal involvement by lymphoma mimicking viral esophagitis in an extranodal NK/T cell lymphoma patient undergoing active treatment.
  • Here, we report a case of esophageal involvement by extranodal NK/T cell lymphoma, nasal type, initially misdiagnosed as Ebstein Barr virus esophagitis.
  • Lymphoma invasion of the esophagus should be considered if esophageal symptoms do not respond to usual medical esophagitis therapy in an extranodal NK/T cell lymphoma, nasal type, patient undergoing chemoradiation.
  • [MeSH-major] Epstein-Barr Virus Infections / pathology. Esophageal Neoplasms / pathology. Esophagitis / pathology. Lymphoma, Extranodal NK-T-Cell / pathology
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Combined Modality Therapy. Diagnosis, Differential. Humans. Male. Middle Aged. Radiotherapy. Tonsillar Neoplasms / pathology. Tonsillar Neoplasms / therapy

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  • (PMID = 20887494.001).
  • [ISSN] 1743-7563
  • [Journal-full-title] Asia-Pacific journal of clinical oncology
  • [ISO-abbreviation] Asia Pac J Clin Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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77. Ma X, Guo Y, Pang Z, Wang B, Lu H, Gu YJ, Guo X: A randomized phase II study of CEOP with or without semustine as induction chemotherapy in patients with stage IE/IIE extranodal NK/T-cell lymphoma, nasal type in the upper aerodigestive tract. Radiother Oncol; 2009 Dec;93(3):492-7
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  • [Title] A randomized phase II study of CEOP with or without semustine as induction chemotherapy in patients with stage IE/IIE extranodal NK/T-cell lymphoma, nasal type in the upper aerodigestive tract.
  • PURPOSE: In this randomized phase II study, we evaluated the efficacy of semustine added to CEOP regimen as induction chemotherapy in patients with stage I(E)/II(E) extranodal NK/T-cell lymphoma, nasal type in the upper aerodigestive tract.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Lymphoma, Extranodal NK-T-Cell / drug therapy. Nose Neoplasms / drug therapy. Semustine / administration & dosage
  • [MeSH-minor] Adult. Aged. Cyclophosphamide / administration & dosage. Cyclophosphamide / adverse effects. Epirubicin / administration & dosage. Epirubicin / adverse effects. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Pharyngeal Neoplasms / drug therapy. Pharyngeal Neoplasms / radiotherapy. Prednisone / administration & dosage. Prednisone / adverse effects. Prognosis. Radiation Injuries. Survival Rate. Vincristine / administration & dosage. Vincristine / adverse effects. Young Adult

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  • (PMID = 19782419.001).
  • [ISSN] 1879-0887
  • [Journal-full-title] Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
  • [ISO-abbreviation] Radiother Oncol
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial
  • [Publication-country] Ireland
  • [Chemical-registry-number] 13909-09-6 / Semustine; 3Z8479ZZ5X / Epirubicin; 5J49Q6B70F / Vincristine; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CEOP protocol 1
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78. Imai H, Sugimoto K, Isobe Y, Sasaki M, Yasuda H, Takeuchi K, Nakamura S, Kojima Y, Tomomatsu J, Oshimi K: Absence of tumor-specific over-expression of Polo-like kinase 1 (Plk1) in major non-Hodgkin lymphoma and relatively low expression of Plk1 in nasal NK/T cell lymphoma. Int J Hematol; 2009 Jun;89(5):673-8
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  • [Title] Absence of tumor-specific over-expression of Polo-like kinase 1 (Plk1) in major non-Hodgkin lymphoma and relatively low expression of Plk1 in nasal NK/T cell lymphoma.
  • Based on the presence of the tumor-specific over-expression of Plk1 (polo-like kinases) in various malignancies, we examined Plk1 expression in nine cases of reactive follicular hyperplasia (RFH), 42 of diffuse large B cell lymphoma (DLBCL), 16 of follicular lymphoma (FL), and 10 of nasal NK/T lymphoma.
  • There was no significant difference in the Plk1-positive cell percentage between RFH and DLBCL.
  • The Plk1-positive cell percentage ranged from 6 to 20% with a median of 12.9% in DLBCL.
  • Plk1-positivity in nasal NK/T cell lymphoma (4.7-14.1% with a median of 9.2%) was significantly higher than that of FL and tended to be lower than DLBCL (p < 0.001, p = 0.05, respectively).
  • Although a strong correlation between positive cell percentages for Plk1 and Ki-67 in these three lymphomas specified Plk1 as a proliferation marker (r = 0.83-0.91), the Plk1-positive cell percentage relative to the other proliferation markers tended to be particularly low in nasal NK/T cell lymphoma.
  • In 41 cases of DLBCL, the positive cell percentages of Plk1 and Ki-67 were both correlated with overall survival.
  • [MeSH-major] Cell Cycle Proteins / analysis. Gene Expression Regulation, Neoplastic. Lymphoma, Extranodal NK-T-Cell / chemistry. Lymphoma, Large B-Cell, Diffuse / chemistry. Lymphoma, Non-Hodgkin / chemistry. Protein-Serine-Threonine Kinases / analysis. Proto-Oncogene Proteins / analysis
  • [MeSH-minor] Biomarkers. Cell Proliferation. Humans. Ki-67 Antigen / analysis. Lymphoma, Follicular / chemistry. Neoplasm Proteins / analysis. Neoplasm Proteins / genetics. Nose Neoplasms / chemistry. Nose Neoplasms / mortality. Prognosis. Survival Analysis

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  • (PMID = 19452252.001).
  • [ISSN] 1865-3774
  • [Journal-full-title] International journal of hematology
  • [ISO-abbreviation] Int. J. Hematol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Cell Cycle Proteins; 0 / Ki-67 Antigen; 0 / Neoplasm Proteins; 0 / Proto-Oncogene Proteins; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; EC 2.7.11.1 / polo-like kinase 1
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79. Miyagi T, Nagasaki A, Taira T, Shinhama A, Suzuki M, Ohshima K, Takasu N: Extranodal adult T-cell leukemia/lymphoma of the head and neck: a clinicopathological study of nine cases and a review of the literature. Leuk Lymphoma; 2009 Feb;50(2):187-95
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  • [Title] Extranodal adult T-cell leukemia/lymphoma of the head and neck: a clinicopathological study of nine cases and a review of the literature.
  • Extranodal adult T-cell leukemia/lymphoma (ATLL) of the head and neck is a rare disease.
  • We studied the clinicopathological features of nine patients with ATLL involving extranodal head and neck sites and conducted a literature review.
  • Six patients presented with extranodal mass of the head and neck, whereas three had disseminated diseases.
  • Histopathology included diffuse pleomorphic-type (with angiocentric features), Hodgkin-like and anaplastic large cell-type.
  • ATLL should be included in the differential diagnosis of extranodal head and neck lymphoma.
  • Localised extranodal ATLL of the head and neck may exhibit indolent clinical behaviours.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Leukemia-Lymphoma, Adult T-Cell / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Male. Middle Aged. Tomography, X-Ray Computed

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  • [CommentIn] Leuk Lymphoma. 2009 Feb;50(2):148-9 [19235009.001]
  • [CommentIn] Leuk Lymphoma. 2009 Feb;50(2):150-1 [19235010.001]
  • (PMID = 19197730.001).
  • [ISSN] 1029-2403
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 50
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80. Cortese L, Paciello O, Papparella S: Morphological characterisation of malignant histiocytosis in a cat. Folia Morphol (Warsz); 2008 Nov;67(4):299-303
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  • [Title] Morphological characterisation of malignant histiocytosis in a cat.
  • Malignant histiocytosis (MH) is a progressive systemic neoplastic proliferation of morphologically atypical histiocytes, well characterised in humans and dogs but only recently identified in the cat.
  • The purpose of this study was to describe the clinical, histological, immunohistochemical and ultrastructural findings of MH in a cat, together with the diagnostic work-up and a list of differential diagnoses.
  • Clinical evaluation included a complete blood-cell count, serum biochemistry, urinalysis, serology and ultrasound examination.
  • The cat had clinical signs of depression, thinness, dehydration, pale mucous membranes and tachycardia.
  • By immunohistochemistry, positivity for lysozyme and alpha1-antitrypsin and a scattered positivity for Mac 387 were observed.
  • MH in the cat needs to be differentiated from diffuse granulomatous disease, non-Hodgkin's lymphoma and Hodgkin's-like disease.
  • The morphological features of the tumour cells, combined with immunohistochemical and ultrastructural observation, are consistent with a diagnosis of MH in the cat.
  • [MeSH-major] Cat Diseases / pathology. Histiocytic Sarcoma / veterinary

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  • (PMID = 19085873.001).
  • [ISSN] 0015-5659
  • [Journal-full-title] Folia morphologica
  • [ISO-abbreviation] Folia Morphol. (Warsz)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
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81. Bhagavathi S, Wilson JD: Primary central nervous system lymphoma. Arch Pathol Lab Med; 2008 Nov;132(11):1830-4
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  • [Title] Primary central nervous system lymphoma.
  • Primary central nervous system lymphoma (PCNSL) is an uncommon extranodal non-Hodgkin lymphoma.
  • Diffuse large B-cell lymphomas constitute most PCNSLs, whereas T-cell, low-grade, anaplastic, and Hodgkin lymphomas are rarely encountered.
  • The morphology of PCNSL shows a characteristic angiocentric pattern and is positive for B-cell markers by immunohistochemistry.
  • The differential diagnosis of PCNSL includes central nervous system gliomas, metastatic tumors, demyelinating disorders, subacute infarcts, and space-occupying lesions due to an infectious etiology.
  • The understanding of the molecular mechanisms involved in the pathogenesis of PCNSL and the identification of molecular biomarkers have lagged behind that of systemic nodal lymphomas.
  • Primary central nervous system lymphomas are treated with combined radiotherapies and chemotherapies.
  • The prognosis for PCNSL is worse than for other extranodal lymphomas.
  • [MeSH-major] Central Nervous System Neoplasms / diagnosis. Lymphoma / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Lymphoma, Large B-Cell, Diffuse / diagnosis. Lymphoma, Large B-Cell, Diffuse / pathology. Middle Aged. Prognosis

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  • (PMID = 18976024.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 24
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82. Borgmann A, Zinn C, Hartmann R, Herold R, Kaatsch P, Escherich G, Möricke A, Henze G, von Stackelberg A, ALL-REZ BFM Study Group: Secondary malignant neoplasms after intensive treatment of relapsed acute lymphoblastic leukaemia in childhood. Eur J Cancer; 2008 Jan;44(2):257-68

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  • [Title] Secondary malignant neoplasms after intensive treatment of relapsed acute lymphoblastic leukaemia in childhood.
  • PURPOSE: To investigate the cumulative incidence of and the risk factors for developing second malignant neoplasms (SMN) in children and adolescents following treatment for relapse of acute lymphocytic leukaemia (ALL).
  • METHODS: Patients (1376) up to 18 years of age with first relapse of non-B-cell ALL were treated and achieved a 2nd complete remission (CR).
  • The incidence of SMN was analysed, correlated with clinical and therapeutic parameters, and compared to the age-specific incidence rates of cancers as cited in German cancer registries.
  • RESULTS: Out of the 1376 patients 21 were diagnosed with SMN including non-lymphoblastic leukaemia/myelodysplastic syndrome (n=6), osteo-/Ewing's-/fibroblastic sarcoma (n=4), B-cell ALL/lymphoma (n=2), thyroid carcinoma (n=2), basal cell carcinoma, adeno carcinoma, squamous cell carcinoma, meningioma, malignant histiocytosis, glioblastoma and anaplastic astrocytoma (n=1 each).
  • SMN was found to be significantly associated with stem cell transplantation (SCT), and high cumulative doses of cranial irradiation, etoposide and cyclophosphamide.
  • CONCLUSIONS: Despite repeated exposure to intense frontline and relapse treatment (including multiagent chemotherapy, cranial irradiation and stem cell transplantation in some patients) the cumulative incidence of SMN was unexpectedly low, though significantly higher than in the general age-matched population.
  • [MeSH-major] Neoplasms, Second Primary / epidemiology. Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy

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  • (PMID = 17981026.001).
  • [ISSN] 0959-8049
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Investigator] Mertens R; Imbach P; Pongratz E; Rupprecht T; Henze G; Wickmann L; Otte J; Bode U; Eberl W; Pekrun A; Kirschstein M; Hofmann K; Frank R; Möbius D; Andler W; Niekrens C; Breu H; Suttorp M; Göbel U; Weinmann G; Sauerbrey A; Beck JF; Janka-Schaub G; Welte K; Kulozik A; Tautz C; Graf N; Fink FM; Zintl F; Hermann J; Rupprath G; Dupuis W; Rodehüser M; Schrappe M; Berthold F; Sternschulte W; Körholz D; Schmitt K; Selle B; Gutjahr P; Dürken M; Christiansen H; Rose M; Borkhardt A; Burdach S; Jürgens H; Scheurlen W; Eggers G; Geib R; Dickerhoff R; Bielack S; Rauh W; Niethammer D; Debatin KM; Gadner H; Dohrn B; Schlegel PG; Niggli F
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83. Li Z, Liu WP, Tang Y, Jiang LL, Zhang WY, Bi CF, Li GD: [Splenic T-cell and NK-cell lymphomas: a clinicopathologic and immunophenotypic analysis of 9 cases]. Zhonghua Xue Ye Xue Za Zhi; 2007 Apr;28(4):217-22

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  • [Title] [Splenic T-cell and NK-cell lymphomas: a clinicopathologic and immunophenotypic analysis of 9 cases].
  • OBJECTIVE: To explore the clinicopathologic features and diagnosis of splenic T-cell and NK-cell neoplasms.
  • METHODS: Nine cases of splenic T-cell and NK-cell neoplasms were collected and studied by morphology, immunophenotyping, EBER in situ hybridization and TCR-gamma gene rearrangement.
  • RESULTS: Among the 9 cases, hepatosplenic T-cell lymphoma (HSTCL) and extranodal nasal type NK/T-cell lymphoma (NK/TCL) were both of 4 cases, and the remaining one was peripheral T-cell lymphoma, unspecified (PTL, unspecified).
  • Five patients including 2 with HSTCL, 2 with extranodal nasal type NK/TCL and one with PTL, unspecified died, with survival times ranged from 1 to 10 months.
  • The other two patients are still alive, one with NK/TCL (two months+) and one with HSTCL (14+ months).
  • CONCLUSION: Splenic T-cell and NK-cell neoplasms are a group of uncommon lymphomas with heterogeneous clinicopathologic features and poor prognosis.
  • A definite diagnosis must depend on clinical manifestations, histopathology, immunophenotype and TCR gene rearrangement analysis.
  • [MeSH-major] Lymphoma, Extranodal NK-T-Cell / pathology. Lymphoma, T-Cell, Peripheral / pathology. Splenic Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Child. Female. Follow-Up Studies. Gene Rearrangement. Humans. Immunophenotyping. Male. Middle Aged

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  • (PMID = 17877195.001).
  • [ISSN] 0253-2727
  • [Journal-full-title] Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
  • [ISO-abbreviation] Zhonghua Xue Ye Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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84. Wang XL, Zhao S, Yu JB, Huang R, Zhang YC, Liu WP: [Construction and expression of recombinant adenovirus carrying human SHP-1 gene]. Sichuan Da Xue Xue Bao Yi Xue Ban; 2007 Jul;38(4):561-4
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  • It could express SHP-1 protein stably and effectively and this will be very helpful for the further study of the generation of extranodal NK/T cell lymphoma and the corresponding therapy.
  • [MeSH-major] Adenoviridae / genetics. DNA, Recombinant / genetics. Genetic Engineering / methods. Protein Tyrosine Phosphatase, Non-Receptor Type 6 / genetics
  • [MeSH-minor] Blotting, Western. Cell Line, Tumor. Gene Expression. Humans. Plasmids / genetics. Polymerase Chain Reaction. Sequence Analysis, DNA. Viral Load

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  • (PMID = 17718411.001).
  • [ISSN] 1672-173X
  • [Journal-full-title] Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
  • [ISO-abbreviation] Sichuan Da Xue Xue Bao Yi Xue Ban
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / DNA, Recombinant; EC 3.1.3.48 / Protein Tyrosine Phosphatase, Non-Receptor Type 6
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85. He YF, Wei W, Sun ZM, Ji CS, Wang G, Chen MP, Hu CL, Hu B: Fatal lactic acidosis and hypoglycemia in a patient with relapsed natural killer/T-cell lymphoma. Adv Ther; 2007 May-Jun;24(3):505-9
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  • [Title] Fatal lactic acidosis and hypoglycemia in a patient with relapsed natural killer/T-cell lymphoma.
  • Presented here is the first reported case of natural killer (NK)/T-cell lymphoma associated with lactic acidosis (LA) and hypoglycemia.
  • LA and hypoglycemia are rare complications of non-Hodgkin's lymphoma.
  • A 28-year-old male patient with NK/T-cell lymphoma had a relapse after 14 mo of initial remission and was admitted to the hospital because of altered mental status.
  • He developed severe LA (pH, 7.17; lactate, 11.2 mmol/L) and hypoglycemia (42 mg/dL) that was resistant to sodium bicarbonate and glucose infusions.
  • A very brief partial remission was achieved after a cycle of vincristine, dexamethasone, and L-asparaginase was given, but the disease recurred quickly after chemotherapy was discontinued and the patient did not respond to additional chemotherapy.
  • The case described here indicates that non-Hodgkin's lymphoma-induced LA portends a poor prognosis.
  • [MeSH-major] Acidosis, Lactic / etiology. Hypoglycemia / etiology. Killer Cells, Natural. Lymphoma, T-Cell / complications. Nose Neoplasms / complications
  • [MeSH-minor] Adult. Fatal Outcome. Humans. Male

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  • (PMID = 17660158.001).
  • [ISSN] 0741-238X
  • [Journal-full-title] Advances in therapy
  • [ISO-abbreviation] Adv Ther
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 18
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86. Maruyama D, Watanabe T, Beppu Y, Kobayashi Y, Kim SW, Tanimoto K, Makimoto A, Kagami Y, Terauchi T, Matsuno Y, Tobinai K: Primary bone lymphoma: a new and detailed characterization of 28 patients in a single-institution study. Jpn J Clin Oncol; 2007 Mar;37(3):216-23
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  • [Title] Primary bone lymphoma: a new and detailed characterization of 28 patients in a single-institution study.
  • BACKGROUND: The incidence of primary bone lymphoma (PBL) is so rare that many of its aspects remain unknown.
  • Although 19 (68%) patients had diffuse large B-cell lymphoma (DLBCL), other histopathological subtypes (three B-lymphoblastic lymphoma, two anaplastic large cell lymphoma, two indolent B-cell lymphoma, one NK/T-cell lymphoma (NTCL) and one Hodgkin lymphoma) were also included.
  • While 68% of patients had stage IV disease, none of them showed bone marrow involvement at their initial diagnosis.
  • CONCLUSIONS: Although the total number of patients was relatively small, the detailed clinical data analyses presented here revealed several new characteristics of PBL and some aspects that may be unique to Japanese patients.
  • [MeSH-major] Bone Neoplasms / pathology. Lymphoma / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Female. Hodgkin Disease / pathology. Humans. Lymphoma, B-Cell / pathology. Male. Middle Aged. Neoplasm Staging. Retrospective Studies. Survival Rate. Treatment Outcome

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  • (PMID = 17472971.001).
  • [ISSN] 1465-3621
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
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87. Rüdiger T, Zettl A, Adam P, Bonzheim I, Geissinger E, Müller-Hermelink HK: [Peripheral NK/T-cell lymphoma]. Pathologe; 2007 Feb;28(1):55-8
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  • [Title] [Peripheral NK/T-cell lymphoma].
  • [Transliterated title] Periphere NK/T-Zell-Lymphome.
  • Peripheral T-cell lymphomas comprise 8% of the malignant lymphomas in Germany.
  • About 25% of these cases present primarily in extranodal localizations.
  • Such localizations are typical for the respective disease and form the basis for the classification of extranodal peripheral T-cell lymphoma.
  • The morphology, immunophenotype and lineage specificity of the tumor cells (originating from T- or NK-cells) is only secondary for the classification.
  • Extranodal NK/T-cell lymphomas of the nasal type are characterized by an angiocentric growth pattern and large confluent areas of necrosis.
  • In the differential diagnosis, B-cell lymphomas are more frequent at all localizations than T- or NK-cell lymphomas.
  • [MeSH-major] Killer Cells, Natural / pathology. Lymphoma, T-Cell / pathology. T-Lymphocytes / immunology
  • [MeSH-minor] Diagnosis, Differential. Humans. Immunophenotyping. Lymphoma, B-Cell / classification. Lymphoma, B-Cell / immunology. Lymphoma, B-Cell / pathology

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  • (PMID = 17195040.001).
  • [ISSN] 0172-8113
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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88. Hashimoto Y, Hashimoto N, Furuta S, Sugawara T, Kosugi N, Hata M, Eguchi M: A case of Epstein-Barr virus-associated natural killer/T-cell lymphoma presenting as dermatomyositis: extranodal relapse after 7 years in remission. Mod Rheumatol; 2005;15(6):435-9

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  • [Title] A case of Epstein-Barr virus-associated natural killer/T-cell lymphoma presenting as dermatomyositis: extranodal relapse after 7 years in remission.
  • He had had a history of extranodal natural killer (NK)/T-cell lymphoma, nasal type, and had been in complete remission for 7 years until June 2003, when he developed high fever, eyelid swelling, and muscular weakness.
  • We report this unique case of Epstein-Barr virus-associated lymphoma mimicking dermatomyositis.

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  • (PMID = 17029109.001).
  • [ISSN] 1439-7595
  • [Journal-full-title] Modern rheumatology
  • [ISO-abbreviation] Mod Rheumatol
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
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89. Weiss DJ: A retrospective study of the incidence and the classification of bone marrow disorders in the dog at a veterinary teaching hospital (1996-2004). J Vet Intern Med; 2006 Jul-Aug;20(4):955-61
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  • BACKGROUND: An 8-year retrospective study was conducted to evaluate the prevalence and the classification of canine bone marrow disorders in a clinical pathology service at a university referral hospital.
  • RESULTS: Bone marrow specimens were first categorized based on the presence or the absence of a primary bone marrow disorder.
  • Frequently observed pathologic disorders included nonregenerative immune-mediated anemia, pure red cell aplasia, bone marrow necrosis, myelofibrosis, and hemophagocytic syndrome.
  • One hundred twenty-six cases of neoplasia were divided into acute leukemia (n = 46), chronic leukemia (n = 7), stage 5 malignant lymphoma (n = 28), multiple myeloma (n = 25), malignant histiocytosis (n = 11), metastatic mast-cell tumor (n = 3), sarcoma (n = 5), and carcinoma (n = 1).
  • CONCLUSIONS AND CLINICAL IMPORTANCE: This study provides a general indication of the spectrum and the prevalence of canine bone marrow disorders at a referral center in North America.

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  • (PMID = 16955822.001).
  • [ISSN] 0891-6640
  • [Journal-full-title] Journal of veterinary internal medicine
  • [ISO-abbreviation] J. Vet. Intern. Med.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
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90. Yasukawa K, Kato N, Kodama K, Hamasaka A, Hata H: The spectrum of cutaneous lymphomas in Japan: a study of 62 cases based on the World Health Organization Classification. J Cutan Pathol; 2006 Jul;33(7):487-91
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  • [Title] The spectrum of cutaneous lymphomas in Japan: a study of 62 cases based on the World Health Organization Classification.
  • BACKGROUND: The relative incidence of malignant lymphoma subtypes differs according to geographic location.
  • This study investigated the epidemiology of cutaneous lymphoma subtypes in Japan and compared it with other countries.
  • METHODS: Sixty-two patients with cutaneous lymphoma attending the Department of Dermatology, National Hospital Organization Hokkaido Cancer Center were reviewed.
  • RESULTS: Of the 62 patients, 31 had primary cutaneous lymphoma (PCL) and 31 had secondary cutaneous lymphoma (SCL).
  • T- and natural killer (NK)-cell lymphoma accounted for 80% of PCL, of which, mycosis fungoides accounted for almost 35%.
  • Of the 31 patients with secondary cutaneous lymphoma, 17 patients (54%) had T- and NK-cell lymphoma, including nine adult T-cell leukemia/lymphoma patients, and 14 patients (46%) had B-cell lymphoma, including 11 diffuse large B-cell lymphoma patients.
  • The majority of patients with SCL and NK-cell lymphoma with primary or secondary skin lesions had a poor outcome.
  • CONCLUSIONS: PCL in this study showed a similar incidence to that of other institutions in Japan, while also demonstrating different frequencies from that of other countries, suggesting that the relative frequency of different PCL subtypes differ according to geographical location, similar to previous reports of systemic malignant lymphoma.
  • [MeSH-major] Lymphoma / epidemiology. Skin Neoplasms / epidemiology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Incidence. Japan / epidemiology. Killer Cells, Natural / pathology. Leukemia, T-Cell / classification. Leukemia, T-Cell / epidemiology. Leukemia, T-Cell / pathology. Lymphoma, B-Cell / classification. Lymphoma, B-Cell / epidemiology. Lymphoma, B-Cell / pathology. Lymphoma, Large B-Cell, Diffuse / classification. Lymphoma, Large B-Cell, Diffuse / epidemiology. Lymphoma, Large B-Cell, Diffuse / pathology. Lymphoma, T-Cell, Cutaneous / classification. Lymphoma, T-Cell, Cutaneous / epidemiology. Lymphoma, T-Cell, Cutaneous / pathology. Male. Middle Aged. Mycosis Fungoides / classification. Mycosis Fungoides / epidemiology. Mycosis Fungoides / pathology. Retrospective Studies. Sezary Syndrome / classification. Sezary Syndrome / epidemiology. Sezary Syndrome / pathology. World Health Organization

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  • (PMID = 16872471.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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91. Mitarnun W, Suwiwat S, Pradutkanchana J: Epstein-Barr virus-associated extranodal non-Hodgkin's lymphoma of the sinonasal tract and nasopharynx in Thailand. Asian Pac J Cancer Prev; 2006 Jan-Mar;7(1):91-4
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  • [Title] Epstein-Barr virus-associated extranodal non-Hodgkin's lymphoma of the sinonasal tract and nasopharynx in Thailand.
  • Epstein-Barr virus (EBV) infection is highly associated with specific subtypes of malignant lymphoma.
  • In our previous report on nodal malignant lymphoma in Thailand, we found that 64% of classical Hodgkin's lymphoma (cHL), 51% of non-Hodgkin's lymphoma, T-cell (NHL-T), and 13% of non-Hodgkin's lymphoma, B-cell (NHL-B) were EBV-related.
  • In the present research, we conducted a retrospective study of primary extranodal non-Hodgkin's lymphoma of the sinonasal tract (e-NHL-ST) and primary extranodal non-Hodgkin's lymphoma of the nasopharynx (e-NHL-NP) in Southern Thailand, between 1997 and 2004.
  • EBV-encoded RNA (EBER) expression by in situ hybridization was performed in all cases and a T-cell receptor (TCR)-g gene rearrangement study was performed in NHL-T cases.
  • There were 18 cases of e-NHL-ST and 42 cases of e-NHL-NP detected by histologic and immunohistochemistry examinations.
  • The percentages of e-NHL-ST and e-NHL-NP as compared to nodal malignant lymphoma were 3.7% and 6.8%, respectively.
  • Sixteen cases (88.9%) of e-NHL-ST and 7 cases (16.7%) of e-NHL-NP were NHL-T, and the remainder were NHL-B.
  • Monoclonal bands of the TCR-gamma gene were detected in 71.4% of the extranodal NK/T-cell lymphomas, nasal type, patients; 50.0% of peripheral T-cell lymphoma, unspecified, patients; and one case of angioimmunoblastic T-cell lymphoma.
  • The study also indicates that most cases of extranodal NK/T-cell lymphoma, nasal type, are not the germline configuration of the TCR genes.
  • [MeSH-major] Herpesvirus 4, Human / isolation & purification. Lymphoma, Non-Hodgkin / epidemiology. Lymphoma, Non-Hodgkin / virology. Nasopharyngeal Neoplasms / virology. Paranasal Sinus Neoplasms / virology
  • [MeSH-minor] Adult. Age Distribution. Aged. Aged, 80 and over. Cohort Studies. DNA, Viral / analysis. Female. Humans. In Situ Hybridization. Incidence. Lymph Nodes / pathology. Lymphoma, T-Cell / epidemiology. Lymphoma, T-Cell / pathology. Lymphoma, T-Cell / virology. Male. Middle Aged. Polymerase Chain Reaction. Prognosis. Retrospective Studies. Risk Assessment. Sex Distribution. Survival Rate. Thailand / epidemiology

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  • (PMID = 16629523.001).
  • [ISSN] 1513-7368
  • [Journal-full-title] Asian Pacific journal of cancer prevention : APJCP
  • [ISO-abbreviation] Asian Pac. J. Cancer Prev.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Thailand
  • [Chemical-registry-number] 0 / DNA, Viral
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92. Thio T, Hilbe M, Grest P, Pospischil A: Malignant histiocytosis of the brain in three dogs. J Comp Pathol; 2006 Feb-Apr;134(2-3):241-4
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  • [Title] Malignant histiocytosis of the brain in three dogs.
  • Three dogs (two Rottweilers and a Flat-coated retriever) showed various neurological signs, including apathy, depression, circling, a partial decrease in functions associated with cranial nerves, seizures, hyperaesthesia, proprioceptive deficits, and increased spinal reflexes.
  • The histological and immunohistochemical examinations indicated a histiocytic origin of the tumour cells and malignant histiocytosis was therefore diagnosed.
  • [MeSH-major] Brain Neoplasms / veterinary. Dog Diseases / pathology. Histiocytic Sarcoma / veterinary

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  • (PMID = 16537081.001).
  • [ISSN] 0021-9975
  • [Journal-full-title] Journal of comparative pathology
  • [ISO-abbreviation] J. Comp. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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93. Meneses-García A, Herrera J, Mohar A, García-Cuellar C, Súchil-Bernal L: [Metalloproteinase (MMP-1, 2 and 11), tissue inhibitor of metalloproteinase-1 (TIMP-1), and p53 expression in nasal-type angiocentric T/NK-cell lymphoma: an immunohistochemical study]. Gac Med Mex; 2005 Jul-Aug;141(4):291-6
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  • [Title] [Metalloproteinase (MMP-1, 2 and 11), tissue inhibitor of metalloproteinase-1 (TIMP-1), and p53 expression in nasal-type angiocentric T/NK-cell lymphoma: an immunohistochemical study].
  • [Transliterated title] Expresión inmunohistoquímica de metaloproteasas (MMP-1, 2 Y 11) e inhibidor de metaloproteasas de tejido-1 (TIMP-1), y expresión de p53 en linfomas angiocéntricos de células T/NK tipo nasal.
  • Twenty cases of extraganglionar Nasal-type T/NK-cell lymphomas were analyzed at the National Cancer Institute of Mexico.
  • We performed immunohistochemistry to determine CD3, CD56, p53 cellular type and expression of (MMPs-1, 2, 11) matrix metalloproteinases and one tissue inhibitor of TIMP-1 metalloproteinase.
  • Demographic variables included, age, sex, primaony location, clinical stage, treatment and follow-up.
  • RESULTS: All studied cases were positive to cytoplasmic CD3, CD56 (NK cells), 19 of them were positive to p53, five of them with nuclear overexpression of p53 in more than 50% of neoplastic cells.
  • DISCUSSION: This type of lymphoma is a common neoplasm in Asia, Latin America and Mexico.
  • It is worth noting it has has been linked to Epstein-Barr virus with T/NK-cell phenotype, which often displays cellular atypia, an angiocentric growth pattern and necrosis.
  • It is clinically expressed by progressive destruction of midline facial soft tissue and has a poor prognosis.
  • [MeSH-major] Lymphoma, T-Cell / metabolism. Metalloproteases / metabolism. Nasal Cavity. Nasopharyngeal Neoplasms / metabolism. Nose Neoplasms / metabolism. Tissue Inhibitor of Metalloproteinase-1 / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Data Interpretation, Statistical. Female. Genes, p53. Humans. Immunohistochemistry. Immunophenotyping. Killer Cells, Natural / pathology. Male. Matrix Metalloproteinases. Middle Aged. Palatal Neoplasms / enzymology. Palatal Neoplasms / genetics. Palatal Neoplasms / metabolism. Palatal Neoplasms / pathology. Prognosis. Tumor Suppressor Protein p53

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  • (PMID = 16164124.001).
  • [ISSN] 0016-3813
  • [Journal-full-title] Gaceta médica de México
  • [ISO-abbreviation] Gac Med Mex
  • [Language] spa
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Mexico
  • [Chemical-registry-number] 0 / Tissue Inhibitor of Metalloproteinase-1; 0 / Tumor Suppressor Protein p53; EC 3.4.- / Metalloproteases; EC 3.4.24.- / Matrix Metalloproteinases
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94. Nakashima Y, Tagawa H, Suzuki R, Karnan S, Karube K, Ohshima K, Muta K, Nawata H, Morishima Y, Nakamura S, Seto M: Genome-wide array-based comparative genomic hybridization of natural killer cell lymphoma/leukemia: different genomic alteration patterns of aggressive NK-cell leukemia and extranodal Nk/T-cell lymphoma, nasal type. Genes Chromosomes Cancer; 2005 Nov;44(3):247-55
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  • [Title] Genome-wide array-based comparative genomic hybridization of natural killer cell lymphoma/leukemia: different genomic alteration patterns of aggressive NK-cell leukemia and extranodal Nk/T-cell lymphoma, nasal type.
  • Natural killer (NK) cell lymphomas/leukemias are highly aggressive lymphoid malignancies, but little is known about their genomic alterations, and thus there is an urgent need for identification and analysis of NK cell lymphomas/leukemias.
  • We performed an array CGH analysis for 27 NK-cell lymphoma/leukemia cases that were classified into two disease groups based on the World Health Organization Classification (10 aggressive NK-cell leukemia cases and 17 extranodal NK/T-cell [NK/T] lymphomas, nasal type).
  • The recurrent regions characteristic of the aggressive NK-cell leukemia group compared with those of the extranodal NK/T lymphoma, nasal-type group, were gain of 1q and loss of 7p15.1-p22.3 and 17p13.1.
  • Recurrent regions characteristic of the extranodal NK/T lymphoma, nasal-type group, compared with those of the other group were gain of 2q, and loss of 6q16.1-q27, 11q22.3-q23.3, 5p14.1-p14.3, 5q34-q35.3, 1p36.23-p36.33, 2p16.1-p16.3, 4q12, and 4q31.3-q32.1.
  • Our results can be expected to provide further insights into the genetic basis of lymphomagenesis and the clinicopathologic features of NK-cell lymphomas/leukemias.
  • [MeSH-major] Chromosome Aberrations. Chromosomes, Human / genetics. Genome, Human. Killer Cells, Natural / pathology. Leukemia, T-Cell / genetics. Lymphoma, T-Cell / genetics. Nose Neoplasms / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Chromosomes, Artificial, Bacterial. DNA, Neoplasm / analysis. Female. Humans. Immunoenzyme Techniques. Karyotyping. Male. Middle Aged. Nucleic Acid Hybridization

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  • [Copyright] (c) 2005 Wiley-Liss, Inc.
  • (PMID = 16049916.001).
  • [ISSN] 1045-2257
  • [Journal-full-title] Genes, chromosomes & cancer
  • [ISO-abbreviation] Genes Chromosomes Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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95. Kim SJ, Kim K, Kim BS, Kim CY, Suh C, Huh J, Lee SW, Kim JS, Cho J, Lee GW, Kang KM, Eom HS, Pyo HR, Ahn YC, Ko YH, Kim WS: Phase II trial of concurrent radiation and weekly cisplatin followed by VIPD chemotherapy in newly diagnosed, stage IE to IIE, nasal, extranodal NK/T-Cell Lymphoma: Consortium for Improving Survival of Lymphoma study. J Clin Oncol; 2009 Dec 10;27(35):6027-32
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  • [Title] Phase II trial of concurrent radiation and weekly cisplatin followed by VIPD chemotherapy in newly diagnosed, stage IE to IIE, nasal, extranodal NK/T-Cell Lymphoma: Consortium for Improving Survival of Lymphoma study.
  • PURPOSE: On the basis of the benefits of frontline radiation in early-stage, extranodal, natural killer (NK)/T-cell lymphoma (ENKTL), we conducted a phase II trial of concurrent chemoradiotherapy (CCRT) followed by three cycles of etoposide, ifosfamide, cisplatin, and dexamethasone (VIPD).
  • PATIENTS AND METHODS: Thirty patients with newly diagnosed, stages IE to IIE, nasal ENKTL received CCRT (ie radiation 40 to 52.8 Gy and cisplatin 30 mg/m(2) weekly).
  • CONCLUSION: Patients with newly diagnosed, stages IE to IIE, nasal ENKTL are best treated with frontline CCRT.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Lymphoma, Extranodal NK-T-Cell / drug therapy. Lymphoma, Extranodal NK-T-Cell / radiotherapy. Nose Neoplasms / drug therapy. Nose Neoplasms / radiotherapy
  • [MeSH-minor] Adult. Aged. Chemotherapy, Adjuvant. Cisplatin / administration & dosage. Dexamethasone / administration & dosage. Disease-Free Survival. Etoposide / administration & dosage. Female. Humans. Ifosfamide / administration & dosage. Kaplan-Meier Estimate. Male. Middle Aged. Neoplasm Recurrence, Local. Neoplasm Staging. Prospective Studies. Radiotherapy, Adjuvant. Republic of Korea. Risk Assessment. Time Factors. Treatment Outcome. Young Adult

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  • [CommentIn] J Clin Oncol. 2010 May 10;28(14):e229; author reply e230 [20351319.001]
  • (PMID = 19884539.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 6PLQ3CP4P3 / Etoposide; 7S5I7G3JQL / Dexamethasone; Q20Q21Q62J / Cisplatin; UM20QQM95Y / Ifosfamide
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96. Xu G, Wang H, He G, Chen D: [Expressions of p53 and p21 in nasal NK/T-cell lymphoma and their relationship with the proliferation and apoptosis of cells]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2009 Jan;23(2):73-6
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  • [Title] [Expressions of p53 and p21 in nasal NK/T-cell lymphoma and their relationship with the proliferation and apoptosis of cells].
  • OBJECTIVE: To investigate the significance of expressions of p53 and p21 in nasal NK/T-cell lymphoma (NKTL) and their relationship with cell proliferation and apoptosis.
  • The intensity of p53 and p21 expression, the Ann Arbor stage and the size of tumor cell all were positively correlated with PI (Spearman correlation analysis, P<0.05), while no correlation with AI (P>0.05).
  • [MeSH-major] Apoptosis. Cell Proliferation. Cyclin-Dependent Kinase Inhibitor p21 / metabolism. Lymphoma, Extranodal NK-T-Cell / pathology. Tumor Suppressor Protein p53 / metabolism
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Humans. Ki-67 Antigen / metabolism. Male. Middle Aged. Young Adult

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  • (PMID = 19452712.001).
  • [ISSN] 1001-1781
  • [Journal-full-title] Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
  • [ISO-abbreviation] Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / CDKN1A protein, human; 0 / Cyclin-Dependent Kinase Inhibitor p21; 0 / Ki-67 Antigen; 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53
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97. Cao MS, Cai HR, Yin HL, Zhang DP, Xiao YL, Cao M, Dai LJ, Hou J: [Primary natural killer/T cell lymphoma of the lung: two cases report and clinical analysis]. Zhonghua Jie He He Hu Xi Za Zhi; 2008 Feb;31(2):120-4
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  • [Title] [Primary natural killer/T cell lymphoma of the lung: two cases report and clinical analysis].
  • OBJECTIVE: To describe the clinical and pathological features of primary NK/T cell lymphoma of the lung.
  • METHODS: Two cases of primary NK/T cell lymphoma of the lung were reported, and the clinical, radiological and pathological characteristics of the disease were discussed with literature review of 3 cases.
  • Immunophenotyping showed CD56(+), CD3(+), perform (+), T-cell intracytoplasmic antigen-1(+) and/or GranB(+), but CD20(-).
  • CONCLUSION: Primary NK/T cell lymphoma of the lung is rare, but should be considered when patients present with lung shadows and fever non-responsive to antibiotics, decreased WBC and increased LDH.
  • [MeSH-major] Lung Neoplasms. Lymphoma, Extranodal NK-T-Cell
  • [MeSH-minor] Adult. Female. Humans. Young Adult

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  • (PMID = 18683784.001).
  • [ISSN] 1001-0939
  • [Journal-full-title] Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases
  • [ISO-abbreviation] Zhonghua Jie He He Hu Xi Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 9
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98. Karantanis D, Subramaniam RM, Peller PJ, Lowe VJ, Durski JM, Collins DA, Georgiou E, Ansell SM, Wiseman GA: The value of [(18)F]fluorodeoxyglucose positron emission tomography/computed tomography in extranodal natural killer/T-cell lymphoma. Clin Lymphoma Myeloma; 2008 Apr;8(2):94-9

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  • [Title] The value of [(18)F]fluorodeoxyglucose positron emission tomography/computed tomography in extranodal natural killer/T-cell lymphoma.
  • PURPOSE: To our knowledge, there are no published data pertinent to the use of [(18F)]fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) in patients with natural killer (NK)/T-cell lymphoma.
  • The purpose of this study was to assess the value of FDG PET/CT in this aggressive type of non-Hodgkin lymphoma.
  • PATIENTS AND METHODS: All patients with NK/T-cell lymphoma referred for FDG PET/CT at our institution from July 2001 to July 2006 were retrospectively studied.
  • The results were compared with the status of the disease, which was determined after evaluation of biopsy, laboratory, clinical and conventional imaging examination, and follow-up results.
  • RESULTS: Twenty-one PET/CT examinations were performed in 10 patients with NK/T-cell lymphoma.
  • For nasal disease, PET/CT was true-positive in 5 cases, true-negative in 15 cases, and positive but unconfirmed in 1 case.
  • The mean SUV(max) in PET-positive lesions in nasal cavities or paranasal sinuses was 16 gm/mL (range, 5-25 gm/mL; median, 19.3 gm/mL).
  • CONCLUSION: Viable NK/T-cell lymphoma is intensely FDG hypermetabolic.
  • [MeSH-major] Fluorodeoxyglucose F18. Killer Cells, Natural / radionuclide imaging. Lymphoma, T-Cell / radionuclide imaging
  • [MeSH-minor] Adult. Female. Humans. Male. Middle Aged. Positron-Emission Tomography / methods. Radioisotopes

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  • (PMID = 18501102.001).
  • [ISSN] 1557-9190
  • [Journal-full-title] Clinical lymphoma & myeloma
  • [ISO-abbreviation] Clin Lymphoma Myeloma
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radioisotopes; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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99. Suzuki R, Takeuchi K, Ohshima K, Nakamura S: Extranodal NK/T-cell lymphoma: diagnosis and treatment cues. Hematol Oncol; 2008 Jun;26(2):66-72

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extranodal NK/T-cell lymphoma: diagnosis and treatment cues.
  • Extranodal NK/T-cell lymphoma, nasal type (ENKL) is mostly endemic to East Asia.
  • It predominantly occurs in the nasal or paranasal areas and less frequently in the skin.
  • Most of the tumours show NK-cell, but rarely T-cell, phenotypes.
  • The Epstein-Barr virus (EBV) genome can be usually detected in lymphoma cells.
  • Originally, NK-cell and T-cell types were believed to present the same clinicopathologic characteristics, but recent data suggest more aggressive characteristics for the NK-cell phenotype.
  • Although ENKL is sensitive to radiotherapy, it shows a poorer response to chemotherapeutic agents than other lymphomas due to expression of p-glycoprotein.
  • Several new clinical trials are now being conducted in East Asia.
  • [MeSH-major] Killer Cells, Natural / cytology. Lymphoma, T-Cell, Peripheral / diagnosis. Lymphoma, T-Cell, Peripheral / therapy
  • [MeSH-minor] Antigens, CD56 / biosynthesis. Antineoplastic Agents / pharmacology. Biopsy. Epstein-Barr Virus Infections / complications. Hematopoietic Stem Cell Transplantation. Herpesvirus 4, Human / metabolism. Humans. Immunophenotyping. Medical Oncology / methods. Models, Biological. P-Glycoprotein / metabolism. Phenotype. Treatment Outcome

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  • (PMID = 18283711.001).
  • [ISSN] 0278-0232
  • [Journal-full-title] Hematological oncology
  • [ISO-abbreviation] Hematol Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD56; 0 / Antineoplastic Agents; 0 / P-Glycoprotein
  • [Number-of-references] 74
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100. Cui XZ, Wang HQ, Liu XM, Zhang HL, Li W: [Treatment outcome and prognosis of autologous hematopoietic stem cell transplantation combined with high dose radiotherapy/chemotherapy in 22 patients with nasal NK/T cell lymphoma]. Zhonghua Xue Ye Xue Za Zhi; 2007 Sep;28(9):609-11
MedlinePlus Health Information. consumer health - Nasal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Treatment outcome and prognosis of autologous hematopoietic stem cell transplantation combined with high dose radiotherapy/chemotherapy in 22 patients with nasal NK/T cell lymphoma].
  • OBJECTIVE: To analyze the outcome and prognosis of autologous hematopoietic stem cell transplantation (AHSCT) combined with high dose radiotherapy/chemotherapy in 22 patients with nasal NK/T cell lymphoma.
  • METHODS: From July 1992 to December 2005, 22 patients with nasal NK/T cell lymphoma were diagnosed pathologically.
  • The patients received cycles of chemotherapy every other two weeks or combined with radiotherapy for remission induction, followed high dose radiotherapy/chemotherapy, combined with autologous peripheral blood stem cell transplantation (APBSCT), or autologous bone-marrow transplantation (ABMT).
  • CONCLUSION: AHSCT combined with high dose radiotherapy/chemotherapy is an effective treatment for patients with poor prognosis nasal NK/T cell lymphoma.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Hematopoietic Stem Cell Transplantation. Lymphoma, Extranodal NK-T-Cell / therapy. Nose Neoplasms / therapy
  • [MeSH-minor] Adult. Aged. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Male. Middle Aged. Prognosis. Transplantation, Autologous. Treatment Outcome

  • Genetic Alliance. consumer health - Transplantation.
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  • (PMID = 18246818.001).
  • [ISSN] 0253-2727
  • [Journal-full-title] Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
  • [ISO-abbreviation] Zhonghua Xue Ye Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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