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1. Bhagavathi S, Wilson JD: Primary central nervous system lymphoma. Arch Pathol Lab Med; 2008 Nov;132(11):1830-4
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  • [Title] Primary central nervous system lymphoma.
  • Primary central nervous system lymphoma (PCNSL) is an uncommon extranodal non-Hodgkin lymphoma.
  • Diffuse large B-cell lymphomas constitute most PCNSLs, whereas T-cell, low-grade, anaplastic, and Hodgkin lymphomas are rarely encountered.
  • The morphology of PCNSL shows a characteristic angiocentric pattern and is positive for B-cell markers by immunohistochemistry.
  • The differential diagnosis of PCNSL includes central nervous system gliomas, metastatic tumors, demyelinating disorders, subacute infarcts, and space-occupying lesions due to an infectious etiology.
  • The understanding of the molecular mechanisms involved in the pathogenesis of PCNSL and the identification of molecular biomarkers have lagged behind that of systemic nodal lymphomas.
  • Primary central nervous system lymphomas are treated with combined radiotherapies and chemotherapies.
  • The prognosis for PCNSL is worse than for other extranodal lymphomas.
  • [MeSH-major] Central Nervous System Neoplasms / diagnosis. Lymphoma / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Lymphoma, Large B-Cell, Diffuse / diagnosis. Lymphoma, Large B-Cell, Diffuse / pathology. Middle Aged. Prognosis

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  • (PMID = 18976024.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 24
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2. Reddy RR, Singh G, Prathima KJ, Harendra Kumar ML: CD-3 positive extranodal T-cell lymphoma of nasal type with skin involvement. Indian J Dermatol Venereol Leprol; 2006 May-Jun;72(3):215-7
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  • [Title] CD-3 positive extranodal T-cell lymphoma of nasal type with skin involvement.
  • Nasal and skin biopsy revealed angiocentric T-cell lymphoma, which on immuno-phenotyping revealed CD-3 positive; and CD-20, CD-30, ALK and EMA negativity.
  • Final diagnosis of CD-3 positive extranodal T-cell lymphoma of nasal type was made.
  • Extranodal T-cell lymphomas are very aggressive NHLs with poor prognosis.
  • Prognosis depends on histology, stage of the disease and sites of involvement.
  • NK/T cell lymphoma of nasal type is common with EBV association.
  • [MeSH-major] Lymphoma, T-Cell / pathology. Nose Neoplasms / pathology. Skin Neoplasms / pathology

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  • (PMID = 16766837.001).
  • [ISSN] 0378-6323
  • [Journal-full-title] Indian journal of dermatology, venereology and leprology
  • [ISO-abbreviation] Indian J Dermatol Venereol Leprol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Antigens, CD3
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3. Cho HI, Hong YS, Lee MA, Kim EK, Yoon SH, Kim CC, Kim TG: Adoptive transfer of Epstein-Barr virus-specific cytotoxic T-lymphocytes for the treatment of angiocentric lymphomas. Int J Hematol; 2006 Jan;83(1):66-73
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  • [Title] Adoptive transfer of Epstein-Barr virus-specific cytotoxic T-lymphocytes for the treatment of angiocentric lymphomas.
  • Angiocentric lymphoma, known as natural killer (NK)/T-cell non-Hodgkin's lymphoma, has been reported to be associated with the Epstein-Barr virus (EBV).
  • We performed adoptive transfer of EBV-specific polyclonal T-cell lines in 3 patients with extranodal NK/T-cell lymphoma, nasal type, and evaluated the treatment for safety, immunologic reconstitution, and clinical outcomes.
  • In the cases of the first and second patients, EBV-transformed B-lymphoblastoid cell lines (LCLs) and T-cell lines were generated from peripheral lymphocytes of HLA-matched sibling donors.
  • The third patient's T-cell lines were induced with autologous lymphocytes.
  • Polyclonal T-cell infusion was carried out after high-dose radiotherapy because active relapsed disease remained in all of the patients.
  • The first patient received 4 weekly infusions of 2 3 10(7) cells/m(2), and the second and third patients underwent treatment with 2 cycles of infusions of the same dosage.
  • All T-cell lines showed >60% NK activity, cytotoxic T-lymphocyte (CTL) responses of >40% against autologous LCLs, and no CTL activity against patient-derived lymphoblasts.
  • The level of cytotoxicity increased substantially in all patients after cell infusion.
  • The 2 patients who received T-cell therapy twice had stabilized disease for more than 3 years.
  • These safe treatments exhibited no severe inflammatory response, and no serious toxicity developed during T-cell therapy.
  • Our findings demonstrate that adoptively transferred cells may provide reconstitution of EBV-specific CTL responses in patients with active relapsed angiocentric lymphoma.
  • These results provide a rationale for the immunotherapy of angiocentric lymphoma.
  • [MeSH-major] Epstein-Barr Virus Infections / therapy. Immunotherapy, Adoptive. Lymphoma, Non-Hodgkin / therapy. Nose Neoplasms / therapy. T-Lymphocytes, Cytotoxic / transplantation
  • [MeSH-minor] Adult. Cell Line. Disease-Free Survival. Herpesvirus 4, Human. Humans. Killer Cells, Natural / pathology. Killer Cells, Natural / virology. Male. Treatment Outcome

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  • (PMID = 16443556.001).
  • [ISSN] 0925-5710
  • [Journal-full-title] International journal of hematology
  • [ISO-abbreviation] Int. J. Hematol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
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4. Peral-Cagigal B, Galdeano-Arenas M, Crespo-Pinilla JI, García-Cantera JM, Sánchez-Cuéllar LA, Verrier-Hernández A: Centrofacial angiocentric lymphoma. Med Oral Patol Oral Cir Bucal; 2005 Jan-Feb;10(1):92-4; 90-2
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  • [Title] Centrofacial angiocentric lymphoma.
  • The centrofacial angiocentric lymphoma is a rare lymphoid neoplasm, with an often-difficult diagnosis due to the non-specific clinical picture.
  • On many occasions it is necessary to perform various biopsies to reach the correct diagnosis.
  • This lymphoma is an aggressive Non-Hodgkin's (NHL) type, which is normally found in the upper respiratory tract (predominantly in the nasal cavity), and has an ominous prognosis, as the average survival rate is between 12 and 18 months (1).
  • After performing a number of diagnostic tests, it was found histologically that the patient had an extranodal T-cell lymphoma of the nasal type (also known as T-cell angiocentric lymphoma).
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Lymphoma, T-Cell / diagnosis

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  • (PMID = 15627913.001).
  • [ISSN] 1698-4447
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng; spa
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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5. Bene NI, Zeitouni NC, Cheney R: Unusual cutaneous manifestation of angiocentric T-cell lymphoma: a case report. Cutis; 2006 May;77(5):310-2
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  • [Title] Unusual cutaneous manifestation of angiocentric T-cell lymphoma: a case report.
  • Angiocentric T-cell lymphoma may clinically present with a broad variety of cutaneous manifestations, including papules, nodules, and ulcerated tumors, and may mimic cutaneous vasculitis and Wegener granulomatosis.
  • Histologic diagnosis of angiocentric T-cell lymphoma also may present a challenge because of variations in the degree of cellular infiltrate and cellular atypia.
  • The correct diagnosis is critical because of the importance of choosing the correct therapeutic modality-chemotherapy or x-ray radiation.
  • We report a case of angiocentric T-cell lymphoma with extensive necrotic facial ulcers that responded to treatment with fludarabine, cyclophosphamide, and prednisone.
  • [MeSH-major] Facial Neoplasms / pathology. Lymphoma, T-Cell, Cutaneous / pathology. Skin Neoplasms / pathology

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  • (PMID = 16776287.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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6. Tiodorović J, Lazarević V, Binić I, Tiodorović-Zivković D: Nasal-type NK/T-cell lymphoma: a case report. Acta Dermatovenerol Alp Pannonica Adriat; 2007 Jun;16(2):73-6
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  • [Title] Nasal-type NK/T-cell lymphoma: a case report.
  • Extranodal NK/T-cell lymphoma represents less than 1% of all lymphomas, but is more common in Asia and South America.
  • Two nodules were taken for biopsy, which showed atypical lymphoid cells with angiocentric growth pattern.
  • The immunophenotype of the tumor cells was CD45RO +, CD56 +, CD3 + (epsilon chain), CD20-, consistent with the diagnosis of NK/T-cell lymphoma.
  • NK/T-cell lymphomas are rare and the optimal treatment has not been clearly established.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Lymphoma, Extranodal NK-T-Cell / pathology. Scalp / pathology. Skin Neoplasms / pathology

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  • (PMID = 17992462.001).
  • [ISSN] 1318-4458
  • [Journal-full-title] Acta dermatovenerologica Alpina, Pannonica, et Adriatica
  • [ISO-abbreviation] Acta Dermatovenerol Alp Pannonica Adriat
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Slovenia
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7. Venetz D, Ponzoni M, Schiraldi M, Ferreri AJ, Bertoni F, Doglioni C, Uguccioni M: Perivascular expression of CXCL9 and CXCL12 in primary central nervous system lymphoma: T-cell infiltration and positioning of malignant B cells. Int J Cancer; 2010 Nov 15;127(10):2300-12
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  • [Title] Perivascular expression of CXCL9 and CXCL12 in primary central nervous system lymphoma: T-cell infiltration and positioning of malignant B cells.
  • Primary central nervous system lymphomas (PCNSL) are aggressive malignancies confined to the CNS, mostly of diffuse large B-cell histotype.
  • Despite improved understanding of the malignant B cells, little is known on the tumor microenvironment and on the response of the adaptive immunity against PCNSL.
  • We investigated the phenotype of tumor infiltrating lymphocytes (TILs), and the expression of chemokines that could affect malignant B cells and trafficking of TILs.
  • Furthermore, we performed in vitro migration assays to analyze the migratory capacity of lymphocytes and malignant B cells toward chemokines and chemokine heterocomplexes.
  • We show in 22 cases of PCNSL from immunocompetent patients that CD8(+) T cells represent the majority of TILs in the tumor mass.
  • In the presence of CXCL9, CXCL12-induced migration is enhanced not only on CXCR4(+)/CXCR3(+)/CD8(+) T cells but also on CXCR4(+)/CXCR3(-) malignant B cells.
  • These findings indicate the presence of a strong chemoattractant stimulus in the perivascular microenvironment, which might serve as regulator for the recruitment of TILs and for the angiocentric positioning of malignant B cells in the perivascular cuff.
  • [MeSH-major] B-Lymphocytes / immunology. Brain Neoplasms / immunology. Chemokine CXCL12 / biosynthesis. Chemokine CXCL9 / biosynthesis. Lymphocytes, Tumor-Infiltrating / immunology. Lymphoma, B-Cell / immunology
  • [MeSH-minor] Adult. Aged. CD8-Positive T-Lymphocytes / immunology. Cell Movement / immunology. Female. Humans. Immunohistochemistry. Lymphocyte Activation. Male. Middle Aged. Receptors, CXCR3 / biosynthesis. Receptors, CXCR3 / immunology. Receptors, CXCR4 / biosynthesis. Receptors, CXCR4 / immunology


8. Pfistershammer K, Petzelbauer P, Stingl G, Mastan P, Chott A, Jäger U, Skrabs C, Geusau A: Methotrexate-induced primary cutaneous diffuse large B-cell lymphoma with an 'angiocentric' histological morphology. Clin Exp Dermatol; 2010 Jan;35(1):59-62
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  • [Title] Methotrexate-induced primary cutaneous diffuse large B-cell lymphoma with an 'angiocentric' histological morphology.
  • A patient with a 25-year history of rheumatoid arthritis and a 3-year history of methotrexate treatment developed a generalized papular rash.
  • Histology revealed a nodular infiltrate composed of a mixture of pleomorphic large B cells positive for CD20, CD30 and CD79a, and of small T cells positive for CD3 and CD4.
  • The T cells had a striking angiocentric distribution, with some of the vessels exhibiting fibrinoid necrosis of the vessel wall reminiscent of lymphomatoid granulomatosis.
  • However, B cells were consistently negative for Epstein-Barr virus (EBV) antigen expression.
  • Thus, this patient was classified as having a rare form of an EBV-negative primary cutaneous T-cell-rich B-cell lymphoma in association with methotrexate treatment.
  • [MeSH-major] Antimetabolites, Antineoplastic / adverse effects. Lymphoma, Large B-Cell, Diffuse / chemically induced. Lymphoma, Large B-Cell, Diffuse / pathology. Methotrexate / adverse effects. Skin Neoplasms / chemically induced. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. B-Lymphocytes / pathology. Diagnosis, Differential. Female. Humans. Pityriasis Lichenoides / pathology. T-Lymphocytes / pathology

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  • (PMID = 19486063.001).
  • [ISSN] 1365-2230
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; YL5FZ2Y5U1 / Methotrexate
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9. Rüdiger T, Zettl A, Adam P, Bonzheim I, Geissinger E, Müller-Hermelink HK: [Peripheral NK/T-cell lymphoma]. Pathologe; 2007 Feb;28(1):55-8
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  • [Title] [Peripheral NK/T-cell lymphoma].
  • [Transliterated title] Periphere NK/T-Zell-Lymphome.
  • Peripheral T-cell lymphomas comprise 8% of the malignant lymphomas in Germany.
  • Such localizations are typical for the respective disease and form the basis for the classification of extranodal peripheral T-cell lymphoma.
  • The morphology, immunophenotype and lineage specificity of the tumor cells (originating from T- or NK-cells) is only secondary for the classification.
  • Extranodal NK/T-cell lymphomas of the nasal type are characterized by an angiocentric growth pattern and large confluent areas of necrosis.
  • In the differential diagnosis, B-cell lymphomas are more frequent at all localizations than T- or NK-cell lymphomas.
  • [MeSH-major] Killer Cells, Natural / pathology. Lymphoma, T-Cell / pathology. T-Lymphocytes / immunology
  • [MeSH-minor] Diagnosis, Differential. Humans. Immunophenotyping. Lymphoma, B-Cell / classification. Lymphoma, B-Cell / immunology. Lymphoma, B-Cell / pathology


10. Kim K, Chie EK, Kim CW, Kim IH, Park CI: Treatment outcome of angiocentric T-cell and NK/T-cell lymphoma, nasal type: radiotherapy versus chemoradiotherapy. Jpn J Clin Oncol; 2005 Jan;35(1):1-5
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  • [Title] Treatment outcome of angiocentric T-cell and NK/T-cell lymphoma, nasal type: radiotherapy versus chemoradiotherapy.
  • OBJECTIVE: The purpose of this study was to evaluate the treatment outcome of angiocentric T-cell and natural killer (NK)/T-cell lymphoma, nasal type.
  • METHODS: Between February 1989 and March 2001, 53 patients with newly diagnosed angiocentric T-cell and NK/T-cell lymphoma, nasal type involving the head and neck, were treated with radiation therapy (RT).
  • CONCLUSIONS: There was no difference in survival between RT and CRT in angiocentric T-cell and NK/T-cell lymphoma, nasal type.
  • [MeSH-major] Killer Cells, Natural. Lymphoma, T-Cell / drug therapy. Lymphoma, T-Cell / radiotherapy. Nose Neoplasms / drug therapy. Nose Neoplasms / radiotherapy

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  • (PMID = 15681596.001).
  • [ISSN] 0368-2811
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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11. Pullarkat VA, Medeiros LJ, Brynes RK: Body cavity-based presentation of natural killer cell lymphoma. Leuk Lymphoma; 2005 Feb;46(2):293-6
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  • [Title] Body cavity-based presentation of natural killer cell lymphoma.
  • We describe an unusual case of a 31-year-old Mexican woman who presented with pleural and peritoneal effusions involved by Epstein-Barr virus-positive non-Hodgkin's lymphoma of natural killer (NK)-cell lineage.
  • Thus, this case clinically mimicked body cavity-based lymphoma.
  • Extranodal NK/T-cell lymphoma of nasal type is the current designation for these neoplasms in the recently proposed World Health Organization classification of lymphoid neoplasms.
  • These tumors previously have been referred to many other names, including lethal midline granuloma, midline malignant reticulosis, polymorphic reticulosis, angiocentric immunoproliferative lesion, and angiocentric lymphoma.
  • Nasal-type NK/T-cell lymphomas typically involve the nasal region, but may involve other extranodal sites, such as skin and gastrointestinal tract.
  • The malignant cytologic features and the presence of azurophilic granules within the cell cytoplasm observed in Wright-Giemsa-stained cytocentrifuge preparations led to immunophenotypic and molecular genetic studies that were essential in establishing the correct diagnosis.
  • As demonstrated in the case reported, extranodal NK/T-cell lymphomas of nasal-type can be clinically aggressive and may be associated with paraneoplastic phenomena.
  • [MeSH-major] Killer Cells, Natural / pathology. Lymphoma, T-Cell / pathology. Nose Neoplasms / diagnosis. Pleural Effusion, Malignant / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Herpesvirus 4, Human / isolation & purification. Humans. Pleural Cavity / pathology

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  • (PMID = 15621817.001).
  • [ISSN] 1042-8194
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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12. Harabuchi Y, Takahara M, Kishibe K, Moriai S, Nagato T, Ishii H: Nasal natural killer (NK)/T-cell lymphoma: clinical, histological, virological, and genetic features. Int J Clin Oncol; 2009 Jun;14(3):181-90
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  • [Title] Nasal natural killer (NK)/T-cell lymphoma: clinical, histological, virological, and genetic features.
  • Nasal natural killer (NK)/T-cell lymphoma (NNKTL) is a clinical illness characterized by progressive unrelenting ulceration and necrosis of the nasal cavity and midline facial tissues.
  • Histological features of the lymphoma include angiocentric and polymorphous lymphoreticular infiltrates, called polymorphic reticulosis.
  • Surface antigens and the NK-cell marker, CD56, as well as pan-T antigen CD2, cytoplasmic CD3 (CD3epsilon), and CD45 are expressed in the lymphoma cells.
  • The origin of the lymphoma is thought to be either NK-cell linkage without T-cell receptor (TCR) rearrangement or gammadeltaT-cell linkage with gammadeltaTCR rearrangement.
  • Since the authors of this study first demonstrated the presence of Epstein Barr virus (EBV)-DNA and EBV oncogenic proteins in NNKTL, the lymphoma has been classified as one of the EBV-associated malignancies.
  • The NNKTL cells produce interleukin (IL)-9, IL-10, and interferon-gamma-inducible protein-10 (IP-10), possibly due to EBV-oncogenic proteins in the lymphoma cells, and such cytokines take an important part in the cell proliferation and invasion, acting in an autocrine manner.
  • Clinically, the serum EBV-DNA copy number is useful as a specific tumor marker and a predictive prognostic factor.
  • Even in early clinical stages, the lymphoma shows poor prognosis caused by the rapid progression of the lesion into distinct organs.
  • In this article, the clinical, pathological, and virological characteristics of the lymphoma are reviewed, along with a report of our investigations.
  • [MeSH-major] Herpesvirus 4, Human / isolation & purification. Killer Cells, Natural / pathology. Lymphoma, T-Cell. Nose Neoplasms

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  • (PMID = 19593607.001).
  • [ISSN] 1341-9625
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Chemokines; 0 / Cytokines
  • [Number-of-references] 65
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13. Furuta K, Nakagawa A, Morita K, Tajiri T, Nishiyama H, Nohgawa M, Ono K, Kobashi Y: [A case of lymphomatoid granulomatosis which initially demonstrated a diffuse ground glass appearance]. Nihon Kokyuki Gakkai Zasshi; 2010 Jan;48(1):49-54
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  • Lymphomatoid granulomatosis is defined as an Epstein-Barr virus-associated B-cell lymphoma which possibly progresses to malignant lymphoma.
  • The pulmonary lesions associated with this disease typically reveal multiple poorly defined nodules.
  • Pathologically, an angiocentric proliferation of large atypical lymphoid cells were observed which were positive for EBER (EBV-encoded small RNA).

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  • (PMID = 20163022.001).
  • [ISSN] 1343-3490
  • [Journal-full-title] Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
  • [ISO-abbreviation] Nihon Kokyuki Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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14. Lucantoni C, De Bonis P, Doglietto F, Esposito G, Larocca LM, Mangiola A, Martini M, Papacci F, Teofili L, Pompucci A: Primary cerebral lymphomatoid granulomatosis: report of four cases and literature review. J Neurooncol; 2009 Sep;94(2):235-42
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  • BACKGROUND: Lymphomatoid granulomatosis (LYG) is an angiocentric and angiodestructive lymphoreticular proliferation, which usually involves the lungs, but may also involve the central nervous system (CNS).
  • CONCLUSIONS: CNS-LYG is a rare disease that should be considered in the differential diagnosis of both diffuse and space-occupying cerebral lesions.
  • [MeSH-minor] Adult. Female. Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor. Herpesvirus 4, Human / genetics. Herpesvirus 4, Human / isolation & purification. Humans. Immunoglobulin Heavy Chains / genetics. Immunophenotyping. In Situ Hybridization. Male. Middle Aged

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  • (PMID = 19322520.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Immunoglobulin Heavy Chains
  • [Number-of-references] 33
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15. Leenman EE, Krivolapov IuA, Morozova EV: [T-cell panniculitis-like lymphoma of the subcutaneous fat: clinicomorphological and immunohistochemical analysis]. Arkh Patol; 2005 Mar-Apr;67(2):43-6
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  • [Title] [T-cell panniculitis-like lymphoma of the subcutaneous fat: clinicomorphological and immunohistochemical analysis].
  • 3 cases of T-cell panniculitis-like lymphoma of the subcutaneous fat are reported.
  • Clinical, histological and immunohistochemical findings are presented.
  • Histologically, we found lobular structure, atypical small and middle-size lymphoid cells, angiocentric growth, erythrophagocytosis.
  • Immunohistochemically it was a cytotoxic phenotype of atypical T-cells.
  • T-cell panniculitis-like lymphoma is a special variant of non-Hodgkin's lymphoma which is diagnosed immunohistochemically.
  • [MeSH-major] Lymphoma, T-Cell, Cutaneous / pathology. Panniculitis / diagnosis. Skin Neoplasms / pathology
  • [MeSH-minor] Adipose Tissue / pathology. Adult. Antigens, CD / metabolism. Biopsy. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Immunophenotyping. Male


16. Watanabe K, Hanamura A, Mori N: A unique case of nasal NK/T cell lymphoma with frequent remission and relapse showing different histological features during 12 years of follow up. J Clin Exp Hematop; 2010;50(1):65-9
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  • [Title] A unique case of nasal NK/T cell lymphoma with frequent remission and relapse showing different histological features during 12 years of follow up.
  • Nasal natural killer (NK)/T cell lymphoma is an aggressive subtype of non-Hodgkin lymphomas, usually with a broad morphological spectrum, necrosis and angioinvasion, and is closely associated with Epstein-Barr virus (EBV) infection.
  • We herein report a unique case of nasal NK/T cell lymphoma with frequent complete remission and relapse 12 years of follow up.
  • A 9-year-old girl was diagnosed as having nasal NK/T cell lymphoma in 1995.
  • The histological features were typical with diffuse lymphoid cell infiltration and angiocentric destruction.
  • At the time of third relapse, however, biopsy showed infiltration of small sized lymphoid cells without necrosis and ulceration.
  • These lymphoid cells were positive for both NK/T cell phenotype and EBV-encoded small RNAs.
  • The tumor regressed spontaneously after biopsy and her clinical symptoms subsided.
  • [MeSH-major] Lymphoma, T-Cell / pathology. Nose Neoplasms / pathology
  • [MeSH-minor] Child. Epstein-Barr Virus Infections / complications. Female. Follow-Up Studies. Humans. Natural Killer T-Cells. Neoplasm Recurrence, Local

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  • (PMID = 20505278.001).
  • [ISSN] 1880-9952
  • [Journal-full-title] Journal of clinical and experimental hematopathology : JCEH
  • [ISO-abbreviation] J Clin Exp Hematop
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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17. Dominguez-Malagon H, Mosqueda-Taylor A, Cano-Valdez AM: Necrotizing sialometaplasia of the palate associated with angiocentric T-cell lymphoma. Ann Diagn Pathol; 2009 Feb;13(1):60-4
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  • [Title] Necrotizing sialometaplasia of the palate associated with angiocentric T-cell lymphoma.
  • In this article we present 2 cases of necrotizing sialometaplasia (NS) associated with angiocentric lymphoma of the midline.
  • Immunohistochemical analysis confirmed a T-cell origin, and in situ hybridization in one case revealed its relationship to Epstein-Barr virus.
  • These findings suggest that vascular occlusion by the neoplastic cells produces ischemia, which leads to local infarction contributing to the salivary gland lesion.
  • To our knowledge, the association between angiocentric lymphoma and NS has been previously reported in only one instance, and we suggest that this particular type of lymphoma should be added to the list of related conditions for NS.
  • [MeSH-major] Epstein-Barr Virus Infections / complications. Lymphoma, T-Cell / complications. Palatal Neoplasms / complications. Paranasal Sinus Neoplasms / complications. Sialometaplasia, Necrotizing / diagnosis. Sialometaplasia, Necrotizing / etiology

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  • (PMID = 19118785.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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18. Kanno H, Onodera H, Endo M, Maeda F, Chida S, Akasaka T, Sawai T: Vascular lesion in a patient of chronic active Epstein-Barr virus infection with hypersensitivity to mosquito bites: vasculitis induced by mosquito bite with the infiltration of nonneoplastic Epstein-Barr virus-positive cells and subsequent development of natural killer/T-cell lymphoma with angiodestruction. Hum Pathol; 2005 Feb;36(2):212-8
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  • [Title] Vascular lesion in a patient of chronic active Epstein-Barr virus infection with hypersensitivity to mosquito bites: vasculitis induced by mosquito bite with the infiltration of nonneoplastic Epstein-Barr virus-positive cells and subsequent development of natural killer/T-cell lymphoma with angiodestruction.
  • This report describes a vasculitis and subsequently developing angiodestructive lymphoma in an 11-year-old Japanese-Filipino girl exhibiting mosquito allergy with the background of chronic active Epstein-Barr virus (EBV) infection.
  • She developed necrotic skin ulcer at the site of mosquito bite, and histopathological examination revealed EBV-positive mononuclear cell infiltration throughout the wall of small-sized muscular artery.
  • These EBV-positive lymphoid cells were oligoclonal in Southern blot analysis for EBV terminal repeats.
  • Microscopically, the angiocentric or angiodestructive pattern of EBV-positive atypical cells supported the diagnosis of extranodal natural killer/T-cell lymphoma.
  • Southern blot analysis revealed the monoclonal neoplastic nature of EBV-positive cells.
  • In contrast to the primary mosquito bite lesion, natural killer/T-cell lymphoma cells exhibited the higher expression of EBV latent membrane protein 1 mRNA and the apparent protein expression detected by immunohistochemistry.
  • [MeSH-major] Culicidae. Epstein-Barr Virus Infections / pathology. Insect Bites and Stings / pathology. Lymphoma, T-Cell, Cutaneous / pathology. Skin / pathology. Vasculitis, Leukocytoclastic, Cutaneous / pathology
  • [MeSH-minor] Animals. Child. Female. Herpesvirus 4, Human / genetics. Herpesvirus 4, Human / isolation & purification. Humans. Immunohistochemistry. Killer Cells, Natural / immunology. Necrosis. RNA, Messenger / metabolism. RNA, Viral / genetics. Viral Matrix Proteins / genetics. Viral Matrix Proteins / metabolism


19. Kanno H, Watabe D, Shimizu N, Sawai T: Adhesion of Epstein-Barr virus-positive natural killer cell lines to cultured endothelial cells stimulated with inflammatory cytokines. Clin Exp Immunol; 2008 Mar;151(3):519-27
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  • [Title] Adhesion of Epstein-Barr virus-positive natural killer cell lines to cultured endothelial cells stimulated with inflammatory cytokines.
  • Approximately one-fourth of CAEBV patients develop vascular lesions with infiltration of EBV-positive lymphoid cells.
  • Furthermore, EBV-positive natural killer (NK)/T cell lymphomas often exhibit angiocentric or angiodestructive lesions.
  • These suggest an affinity of EBV-positive NK/T cells to vascular components.
  • In this study, we evaluated the expression of adhesion molecules and cytokines in EBV-positive NK lymphoma cell lines, SNK1 and SNK6, and examined the role of cytokines in the interaction between NK cell lines and endothelial cells.
  • SNKs expressed intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) at much higher levels than those in EBV-negative T cell lines.
  • SNKs produced the larger amount of tumour necrosis factor (TNF)-alpha, which caused increased expression of ICAM-1 and VCAM-1 in cultured human endothelial cells, than that from EBV-negative T cell lines.
  • Furthermore, SNKs exhibited increased adhesion to cultured endothelial cells stimulated with TNF-alpha or interleukin (IL)-1beta, and the pretreatment of cytokine-stimulated endothelial cells with anti-VCAM-1-antibodies reduced cell adhesion.
  • These indicate that the up-regulated expression of VCAM-1 on cytokine-stimulated endothelial cells would be important for the adhesion of EBV-positive NK cells and might initiate the vascular lesions.
  • [MeSH-major] Cytokines / immunology. Endothelium, Vascular / immunology. Herpesvirus 4, Human / isolation & purification. Killer Cells, Natural / virology
  • [MeSH-minor] Cell Adhesion / immunology. Endothelial Cells / immunology. Humans. Integrin alpha4beta1 / metabolism. Intercellular Adhesion Molecule-1 / immunology. Intercellular Adhesion Molecule-1 / metabolism. Lymphocyte Function-Associated Antigen-1 / metabolism. Lymphoma, T-Cell / immunology. Lymphoma, T-Cell / virology. Tumor Cells, Cultured. Vascular Cell Adhesion Molecule-1 / immunology. Vascular Cell Adhesion Molecule-1 / metabolism

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  • (PMID = 18190605.001).
  • [ISSN] 1365-2249
  • [Journal-full-title] Clinical and experimental immunology
  • [ISO-abbreviation] Clin. Exp. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cytokines; 0 / Integrin alpha4beta1; 0 / Lymphocyte Function-Associated Antigen-1; 0 / Vascular Cell Adhesion Molecule-1; 126547-89-5 / Intercellular Adhesion Molecule-1
  • [Other-IDs] NLM/ PMC2276960
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20. Ishida F, Kwong YL: Diagnosis and management of natural killer-cell malignancies. Expert Rev Hematol; 2010 Oct;3(5):593-602
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnosis and management of natural killer-cell malignancies.
  • Natural killer (NK)-cell malignancies are uncommon neoplasms, which have been referred to as polymorphic reticulosis or angiocentric T-cell lymphomas in the past.
  • In the current WHO classification, they are categorized as extranodal NK/T-cell lymphoma, nasal type and aggressive NK-cell leukemia.
  • NK-cell malignancies show a geographical predilection for Asian and South American populations and are rare in the west.
  • Pathologically, NK-cell lymphomas show a polymorphic neoplastic infiltrate with angioinvasion and angiodestruction.
  • The lymphoma cells are CD2(+), cytoplasmic CD3ε(+) and CD56(+), with germline T-cell receptor gene.
  • Clinically, NK-cell lymphomas can be classified into nasal, non-nasal and aggressive lymphoma/leukemia subtypes.
  • Most nasal NK-cell lymphomas present with stage I/II disease.
  • Chemotherapy is indicated for stage III/IV nasal NK-cell lymphoma, and the non-nasal and aggressive subtypes.
  • High-dose chemotherapy and hematopoietic stem-cell transplantation with autologous or allogeneic hematopoietic stem cells may be beneficial to selected patients.
  • Prognostication of patients with clinical prognostic models and presentation circulating Epstein-Barr DNA load may be useful in the stratification of patients for various treatment modalities.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Asparaginase / administration & dosage. Killer Cells, Natural / drug effects. Leukemia / diagnosis. Leukemia / therapy. Lymphoma, Extranodal NK-T-Cell / diagnosis. Lymphoma, Extranodal NK-T-Cell / therapy
  • [MeSH-minor] Antigens, CD. Asia / epidemiology. Female. Hematopoietic Stem Cell Transplantation. Herpesvirus 4, Human. Humans. Male. Middle Aged. Prognosis. Recurrence. Severity of Illness Index. South America / epidemiology. Transplantation, Autologous

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  • (PMID = 21083476.001).
  • [ISSN] 1747-4094
  • [Journal-full-title] Expert review of hematology
  • [ISO-abbreviation] Expert Rev Hematol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD; EC 3.5.1.1 / Asparaginase
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21. Nishihara H, Tateishi U, Itoh T, Nagashima K, Tanaka S: Immunohistochemical and gene rearrangement studies of central nervous system lymphomatoid granulomatosis. Neuropathology; 2007 Oct;27(5):413-8
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  • Lymphomatoid granulomatosis (LYG) is a rare multisystem disorder with characteristic angiocentric lymphoproliferative features, most frequently involving the lung, skin, and rarely the CNS.
  • LYG has been classified into three subtypes based on the relative proportions of atypical and inflammatory infiltrating cells.
  • Most systemic LYGs have been shown to be EBV-associated, T-cell rich, B-cell proliferative disorders.
  • Here, we present four cases of LYG arising from the CNS and have analyzed them by immunohistochemistry to assess the phenotype of the infiltrate, and by PCR-SSCP (single-strand conformation polymorphism) analysis for immunoglobulin heavy chain (IgH) and T-cell receptor (TcR) gamma gene rearrangements.
  • Three cases revealed perivascular infiltration of T-cell dominant lymphoid cells, two cases showed monoclonal TcRgamma gene rearrangement, while the remaining case had a B-cell immunophenotype and monoclonal IgH gene rearrangement with EBV genome expression.
  • We confirm that some cases of CNS-LYG are derived from T-cell monoclonal lymphoproliferative disease, although this disease should be classified as a borderline malignancy and should be separated from overt malignant lymphoma of CNS.
  • [MeSH-major] Central Nervous System Diseases / pathology. Gene Rearrangement. Genes, T-Cell Receptor gamma. Immunoglobulin Heavy Chains / genetics. Lymphomatoid Granulomatosis / pathology
  • [MeSH-minor] Antigens, CD / analysis. Humans. Immunohistochemistry. In Situ Hybridization. Phenotype. Polymerase Chain Reaction. Polymorphism, Single-Stranded Conformational. Receptors, Antigen, T-Cell, gamma-delta / genetics

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  • (PMID = 18018473.001).
  • [ISSN] 0919-6544
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Immunoglobulin Heavy Chains; 0 / Receptors, Antigen, T-Cell, gamma-delta
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22. Miyagi T, Nagasaki A, Taira T, Shinhama A, Suzuki M, Ohshima K, Takasu N: Extranodal adult T-cell leukemia/lymphoma of the head and neck: a clinicopathological study of nine cases and a review of the literature. Leuk Lymphoma; 2009 Feb;50(2):187-95
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  • [Title] Extranodal adult T-cell leukemia/lymphoma of the head and neck: a clinicopathological study of nine cases and a review of the literature.
  • Extranodal adult T-cell leukemia/lymphoma (ATLL) of the head and neck is a rare disease.
  • Histopathology included diffuse pleomorphic-type (with angiocentric features), Hodgkin-like and anaplastic large cell-type.
  • Five patients with localised disease showed prolonged survival regardless of unfavourable histology and/or aberrant provirus status, including integration of multiple copies or defective provirus.
  • Patients with localised disease documented in the literature, including our study series, had a reduced frequency of elevated lactate dehydrogenase, no hypercalcemia and longer survival.
  • ATLL should be included in the differential diagnosis of extranodal head and neck lymphoma.
  • Localised extranodal ATLL of the head and neck may exhibit indolent clinical behaviours.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Leukemia-Lymphoma, Adult T-Cell / pathology

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  • [CommentIn] Leuk Lymphoma. 2009 Feb;50(2):148-9 [19235009.001]
  • [CommentIn] Leuk Lymphoma. 2009 Feb;50(2):150-1 [19235010.001]
  • (PMID = 19197730.001).
  • [ISSN] 1029-2403
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 50
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23. Meneses-García A, Betancourt AM, Abarca JH, Montes AB, Roa LS, Ruíz-Godoy L: Expression of the metalloproteases MMP-1, MMP-2, MMP-3, MMP-9, MMP-11, TIMP-1 and TIMP-2 in angiocentric midfacial lymphomas. World J Surg Oncol; 2008;6:114
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  • [Title] Expression of the metalloproteases MMP-1, MMP-2, MMP-3, MMP-9, MMP-11, TIMP-1 and TIMP-2 in angiocentric midfacial lymphomas.
  • BACKGROUND: Extranodal T/NK cell lymphomas possess distinctive clinico-pathological characteristics: they are angiocentric, exhibit extensive necrosis.
  • The objective is to explore the expression of different MMPs in the cells and stroma which are around of the blood vessels damaged and their correlation with clinico-pathological parameters.
  • PATIENTS AND METHODS: Twenty cases of this type of lymphomas were studied and collected patient clinical data.
  • The 55% advanced clinical stages, 70% died from the disease.
  • There were neoplastic cell and peritumoral fibroblasts positivity to MMP-1 and MMP-11 in most of the cases.
  • The MMPs-2, 3 and 9 were expressed in neoplastic cell between 30 to 65%of the cases.
  • CONCLUSION: There were no statistical significance between the different enzymes used and the clinical parameters, besides status and survival of the patients.
  • It is necessary to study more enzymes and focus them to quantify and determine their activity, in order to have a better correlation with histological features in this type of neoplasm.
  • [MeSH-major] Biomarkers, Tumor / analysis. Lymphoma, Extranodal NK-T-Cell / mortality. Lymphoma, Extranodal NK-T-Cell / pathology. Matrix Metalloproteinases / metabolism. Nose Neoplasms / mortality. Nose Neoplasms / pathology

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  • (PMID = 18954439.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Tissue Inhibitor of Metalloproteinase-1; 127497-59-0 / Tissue Inhibitor of Metalloproteinase-2; EC 3.4.24.- / Matrix Metalloproteinases; EC 3.4.24.24 / Matrix Metalloproteinase 2; EC 3.4.24.35 / Matrix Metalloproteinase 9
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24. Chilosi M, Zinzani PL, Poletti V: Lymphoproliferative lung disorders. Semin Respir Crit Care Med; 2005 Oct;26(5):490-501
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Although the lung is frequently involved by disseminated lymphoma, isolated pulmonary lymphoma is rare, accounting for less than 1% of all extranodal localized disease.
  • Three broad categories of lymphoma of the lung require recognition: in rare instances, large B cell type lymphoma can present primarily in the lung; a second variant is by T cell lymphoma presenting as an angiocentric process.
  • However, the most common histologic subtype is represented by low-grade mucosa-associated lymphoid tissue (MALT) lymphoma, often in the past considered as a pseudotumor because of its long indolent natural history.
  • Common presenting features include cough, dyspnea, pain, fever, recurrent infections, hemoptysis, or an asymptomatic finding on routine chest radiograph.
  • Precise pathological diagnosis and molecular characterization are required in all cases, following World Health Organization classification criteria.
  • [MeSH-major] Lung Diseases / diagnosis. Lymphoproliferative Disorders / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Diagnostic Imaging. Humans. Neoplasm Staging

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  • (PMID = 16267700.001).
  • [ISSN] 1069-3424
  • [Journal-full-title] Seminars in respiratory and critical care medicine
  • [ISO-abbreviation] Semin Respir Crit Care Med
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 98
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25. Ferenczi K, Summers P, Aubert P, Cooper B, Meyerson H, Cooper KD, Honda K: A case of CD30+ nasal natural killer/T-cell lymphoma. Am J Dermatopathol; 2008 Dec;30(6):567-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of CD30+ nasal natural killer/T-cell lymphoma.
  • Extranodal nasal natural killer (NK)/T-cell lymphoma is a very rare lymphoma characterized by strong association with Epstein-Barr virus infection, very aggressive clinical behavior, and poor prognosis.
  • The typical phenotype of neoplastic natural killer cells in this entity is as follows: CD2+, CD56+, surface CD3-, cytoplasmic CD3epsilon+, and cytotoxic granule-associated protein positive.
  • CD30 expression, a phenotype characteristic of anaplastic large-cell lymphomas, is not a typical feature of nasal NK/T-cell lymphomas.
  • A skin biopsy revealed an atypical angiocentric mononuclear cell infiltrate.
  • Strong CD30 and CD3e immunoreactivities were noted in large atypical mononuclear cells within the infiltrate initially suggestive of a CD30+ T-cell lymphoma.
  • However, flow cytometry of the skin lesion indicated that the cells were CD2+, CD4-, CD8-, and lacked surface CD3 more typical of a neoplasm of natural killer cells.
  • Further studies revealed that the cells were CD56+, T-cell-restricted intracellular antigen-1+, and contained Epstein-Barr virus sequences consistent with a nasal-type NK/T-cell lymphoma.
  • High titers of Epstein-Barr virus in the blood, evidence of sinonasal disease, and absence of a T-cell receptor gene rearrangement were additional features consistent with the diagnosis.
  • The patient had a very aggressive clinical course and, despite combination chemotherapy, died 8 months after the onset of skin lesions.
  • This case represents an example of nasal-type NK/T-cell lymphoma with expression of CD30.
  • When presenting in the skin, the phenotypic and morphologic features of this lymphoma may lead to an erroneous diagnosis of a CD30+ large-T-cell lymphoma.
  • [MeSH-major] Antigens, CD30 / metabolism. Lymphoma, T-Cell, Cutaneous / diagnosis. Natural Killer T-Cells / immunology. Natural Killer T-Cells / pathology. Nose Neoplasms / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Immunophenotyping. Lymphoma, Large-Cell, Anaplastic / diagnosis. Lymphoma, Large-Cell, Anaplastic / immunology. Lymphoma, Large-Cell, Anaplastic / pathology

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  • (PMID = 19033930.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD30
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26. Magro CM, Dyrsen M: Angiocentric lesions of the head and neck. Head Neck Pathol; 2008 Jun;2(2):116-30
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  • [Title] Angiocentric lesions of the head and neck.
  • Angiocentric lesions of the head and neck encompass a variety of benign and malignant lesions.
  • Not unexpectedly the sequelae of an angiocentric process independent of its benign or malignant nature is one of tissue ischemia with a potential for either breakdown or reparative fibrosis.
  • Therefore, the clinical presentations can be very similar despite a varied pathogenesis.
  • Among the benign reactive infiltrates that will be considered are angiocentric eosinophilic fibrosis, Wegener's granulomatosis, microscopic polyangiitis and cocaine associated mid line facial destruction.
  • We will discuss other conditions which enter into the differential diagnosis either clinically or histologically including Erdheim Chester disease and mid line facial undermining unrelated to an angiocentric event specifically in the context of trigeminal trophic ulcer and relapsing polychondritis.
  • The two main neoplastic conditions exhibiting angiocentricity are in the context of lymphomatoid granulomatosis and NK/T cell lymphoma; hence these two particular hematologic dyscrasias will be discussed in some detail in this review.
  • [MeSH-minor] Granulomatosis with Polyangiitis / complications. Granulomatosis with Polyangiitis / pathology. Head and Neck Neoplasms / blood supply. Head and Neck Neoplasms / complications. Head and Neck Neoplasms / pathology. Humans. Lymphoma, B-Cell / complications. Lymphoma, B-Cell / pathology. Lymphoma, Extranodal NK-T-Cell / complications. Lymphoma, Extranodal NK-T-Cell / pathology. Nasopharyngeal Neoplasms / blood supply. Nasopharyngeal Neoplasms / complications. Nasopharyngeal Neoplasms / pathology. Polychondritis, Relapsing / complications. Polychondritis, Relapsing / pathology

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  • (PMID = 20614334.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Congresses
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2807549
  • [Keywords] NOTNLM ; Microscopic polyarteritis (PAN) / Allergic granulomatosis of Churg Strauss (AGCS) / Angiocentric lesions / Chronic cocaine abuse / Eosinophilic angiocentric fibrosis (EAF) / Head / Lymphomatoid granulomatosis (LYG) / Natural killer/T-cell lymphomas / Neck / Relapsing polychondritis / Trigeminal trophic ulcer / Wegener's granulomatosis (WG)
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27. Laetsch B, Hofbauer G, Kempf W, Burg G, Dummer R: Atypical poorly differentiated cutaneous T-cell lymphoma with an angiocentric growth pattern presenting histologically as vasculitis. Dermatology; 2005;210(4):341-5
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  • [Title] Atypical poorly differentiated cutaneous T-cell lymphoma with an angiocentric growth pattern presenting histologically as vasculitis.
  • We report the case of a 41-year-old patient with an aggressive cutaneous T-cell lymphoma (CTCL) initially presenting on histology as lymphocytic vasculitis.
  • On repeated histological examination and by molecular biology work-up, the diagnosis of an unclassifiable CTCL could eventually be established.
  • This atypical poorly differentiated lymphoma was of a CD4+ CD8- CD56- phenotype and followed an unfavourable course.
  • The patient died despite chemo- and immunotherapy 7 months after the first consideration of lymphoma as diagnosis.
  • [MeSH-major] Lymphoma, T-Cell, Cutaneous / pathology. Skin Neoplasms / pathology. Vasculitis / pathology
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biopsy, Needle. Diagnosis, Differential. Disease Progression. Fatal Outcome. Humans. Immunohistochemistry. Male. Risk Assessment


28. Li L, Liu YH, Zhuang HG, Luo XL, Zhang F, Xu FP, Luo DL: [Extranodal nasal type NK/T-cell lymphoma: clinicopathologic and prognostic study of 55 cases]. Zhonghua Bing Li Xue Za Zhi; 2009 Apr;38(4):237-42
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  • [Title] [Extranodal nasal type NK/T-cell lymphoma: clinicopathologic and prognostic study of 55 cases].
  • OBJECTIVE: To study the clinicopathologic features and prognostic factors of extranodal nasal type NK/T-cell lymphoma (EN-NK/TCL) in Chinese patients.
  • METHODS: Fifty-five cases of EN-NK/TCL diagnosed in Chinese patients during the period from 1998 to 2007 were studied by light microscopy, immunohistochemistry and in-situ hybridization.
  • Histologically, EN-NK/TCL was composed of small to medium-sized lymphoid cells.
  • Angiocentric and angiodestructive growth patterns, coagulative tumor necrosis and apoptotic bodies were frequently observed.
  • Immunohistochemical study showed that CD20, the B-cell marker, was negative in all cases.
  • The positivity rates for T-cell markers CD3epsilon, CD4, CD5 and CD8 were 100% (49/49), 7% (3/46), 8% (4/48) and 63% (29/46), respectively.
  • Most cases were also positive for NK-cell marker CD56 (79% 42/53).
  • There was a significant positive correlation between the bcl-2 positive expression and a high Ki-67 expression level.
  • Amongst the 41 cases with clinical information available, 63.4% presented with Ann Arbor stage I to II.
  • CONCLUSIONS: EN-NK/TCL is a mature T-cell and NK-cell neoplasm which can be accurately diagnosed by histologic examination, immunohistochemical study and in-situ hybridization.
  • [MeSH-major] Antigens, CD3 / metabolism. Epstein-Barr Virus Infections. Herpesvirus 4, Human. Lymphoma, Extranodal NK-T-Cell. Nose Neoplasms
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Antigens, CD56 / metabolism. Child. Female. Follow-Up Studies. Granzymes / metabolism. Humans. Immunophenotyping. Ki-67 Antigen / metabolism. Male. Middle Aged. Neoplasm Staging. Poly(A)-Binding Proteins / metabolism. Proto-Oncogene Proteins c-bcl-2 / metabolism. RNA, Viral / analysis. Retrospective Studies. Survival Rate. Young Adult

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  • (PMID = 19575894.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD3; 0 / Antigens, CD56; 0 / CD3E protein, human; 0 / Ki-67 Antigen; 0 / Poly(A)-Binding Proteins; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / RNA, Viral; 0 / TIA1 protein, human; EC 3.4.21.- / Granzymes
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29. Nigidie A, Schneider J: Nasal NK/T-cell lymphoma causing diagnostic difficulties. Ethiop Med J; 2005 Jul;43(3):197-201
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  • [Title] Nasal NK/T-cell lymphoma causing diagnostic difficulties.
  • We present history, clinical presentation and anatomo-pathologic findings of a 24-year-old female patient with a nasal NK/T-cell lymphoma.
  • This rare tumor is characterized by its angiocentric and angiodestructive growth, which results in extensive tumor necrosis.
  • At the first encounter this tumor necrosis made it difficult to identify the nature of the tumor cells.
  • However, this necrosis is a key feature: it is the result of the capacity of neoplastic NK/T-cells to invade vessels.
  • The T-cell character of the neoplastic lymphoid has been shown by immunohistochemitry.
  • [MeSH-major] Granuloma, Lethal Midline / diagnosis. Killer Cells, Natural. Lymphoma, T-Cell / diagnosis. Nose / physiopathology. Nose Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Fatal Outcome. Female. Humans

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  • (PMID = 16370552.001).
  • [ISSN] 0014-1755
  • [Journal-full-title] Ethiopian medical journal
  • [ISO-abbreviation] Ethiop. Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Ethiopia
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30. Moradi S, Chavoshzadeh Z, Izadyar M, Mahjoub F, Rezaei N: Angiocentric nasal T-cell lymphoma in a patient withidiopathic CD4+ lymphocytopenia. Iran J Allergy Asthma Immunol; 2009 Dec;8(4):215-8
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  • [Title] Angiocentric nasal T-cell lymphoma in a patient withidiopathic CD4+ lymphocytopenia.
  • Idiopathic CD4+ Lymphocytopenia is a rare combined immunodeficiency disease, characterized by low CD4+ T-cell count and increased susceptibility to opportunistic infections, autoimmunity and malignancies after exclusion of secondary forms of CD4 lymphocytopenia.
  • Laboratory studies revealed very low number of CD4+ T-cells (<100 cells/mm(3)).
  • Immunohistological studies of destructive lesions in oral and nasal cavity revealed angiocentric T-cell lymphoma.
  • This patient is the first reported case of lethal midline granuloma with origin T-cell lymphoma in idiopathic CD4+ lymphocytopenia.
  • [MeSH-major] CD4-Positive T-Lymphocytes / pathology. Lymphoma, T-Cell. Lymphopenia. Nose Neoplasms

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  • (PMID = 20404393.001).
  • [ISSN] 1735-1502
  • [Journal-full-title] Iranian journal of allergy, asthma, and immunology
  • [ISO-abbreviation] Iran J Allergy Asthma Immunol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Iran
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31. Qin W, Yin Z, Madge SN: Acute presentation of nasal-type natural killer/T-cell lymphoma of the orbit. Eur J Ophthalmol; 2009 Jul-Aug;19(4):679-82
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  • [Title] Acute presentation of nasal-type natural killer/T-cell lymphoma of the orbit.
  • PURPOSE: An unusual case of nasal-type natural killer/T-cell lymphoma (NKTL) of the orbit is reported.
  • METHODS: The clinical history, computed tomography, magnetic resonance imaging, and biopsy specimen of a 29-year-old man with a right orbital lymphoma were evaluated.
  • Orbital biopsy revealed angiodestruction with prominent necrosis, and angiocentric lymphoma growth and lymphoma cells were positively stained for CD3, CD20, CD45RO, CD56, cytotoxic molecules (granzyme B and T-cell intracellular antigen-1), and Epstein-Barr virus.
  • CONCLUSIONS: NKTL is rare and may present acutely; the imaging findings presented serve to highlight the radiologic features of the disease.
  • [MeSH-major] Killer Cells, Natural / pathology. Lymphoma, T-Cell / diagnosis. Orbital Neoplasms / diagnosis
  • [MeSH-minor] Adult. Antigens, CD / analysis. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / analysis. Conjunctival Diseases / diagnosis. Cyclophosphamide / therapeutic use. Doxorubicin / therapeutic use. Exophthalmos / diagnosis. Glucocorticoids / therapeutic use. Humans. Magnetic Resonance Imaging. Male. Prednisone / therapeutic use. Tomography, X-Ray Computed. Vincristine / therapeutic use. Vision Disorders / diagnosis

  • Hazardous Substances Data Bank. DOXORUBICIN .
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  • (PMID = 19551687.001).
  • [ISSN] 1120-6721
  • [Journal-full-title] European journal of ophthalmology
  • [ISO-abbreviation] Eur J Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Biomarkers, Tumor; 0 / Glucocorticoids; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CHOP protocol
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32. Yoshioka T, Harada M, Umekita Y, Taguchi S, Higashi M, Nakamura D, Suzuki S, Tanimoto A: Necrotizing sialometaplasia of the parotid gland associated with angiocentric T-cell lymphoma: a case report and review of the literature. Pathol Int; 2010 Apr;60(4):326-9
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  • [Title] Necrotizing sialometaplasia of the parotid gland associated with angiocentric T-cell lymphoma: a case report and review of the literature.
  • A very rare case of necrotizing sialometaplasia of the parotid gland associated with angiocentric T-cell lymphoma was described.
  • A 66-year-old male had left neck and pharyngeal masses and biopsy specimen showed a monotonous proliferation of atypical lymphoid cells with massive necrosis in the parotid gland.
  • Angiocentric pattern or vascular invasion by the lymphoid cells was observed and the involved parotid gland exhibited squamous metaplasia of the ducts and acini; necrotizing sialometaplasia.
  • Immunohistochemical analysis revealed a cytotoxic T-cell phenotype of the lymphoid cells (CD3+, CD4-, CD5+, CD8+, CD56-, Granzyme B+, TIA-1+, Perforin-) but in situ hybridization showed no relation to Epstein-Barr virus.
  • Although necrotizing sialometaplasia is relatively rare in the parotid gland, angiocentric T-cell lymphoma should be considered for a causative condition of necrotizing sialometaplasia.
  • [MeSH-major] Lymphoma, T-Cell / pathology. Neovascularization, Pathologic / pathology. Parotid Gland / pathology. Sialometaplasia, Necrotizing / pathology

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  • (PMID = 20403036.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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33. Yu JH, Choi KD, Koh YW, Choi WJ, Song HJ, Lee GH, Jung HY, Kim JH: [A case of CD56+ extranodal NK/T-cell lymphoma, nasal type, presenting as a duodenal ulcer bleeding]. Korean J Gastroenterol; 2009 Sep;54(3):174-9
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  • [Title] [A case of CD56+ extranodal NK/T-cell lymphoma, nasal type, presenting as a duodenal ulcer bleeding].
  • Extranodal NK/T-cell lymphoma is a recently recognized distinct entity within the World Health Organization classification of lymphoid tumors.
  • Among these, extranodal NK/T-cell lymphoma of the gastrointestinal tract has shown an aggressive clinical course.
  • We report a case of CD56+ extranodal NK/T-cell lymphoma presenting as a duodenal ulcer bleeding.
  • Pathologic examination revealed the diffuse infiltration of atypical lymphocytes with an angiocentric growth pattern, which was positive for CD3, CD56, and granzyme.
  • The patient showed rapid deteriorating clinical course and died on day 14 after admission.
  • [MeSH-major] Antigens, CD56 / metabolism. Duodenal Ulcer / diagnosis. Lymphoma, Extranodal NK-T-Cell / diagnosis. Peptic Ulcer Hemorrhage / diagnosis

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  • (PMID = 19844154.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Antigens, CD3; 0 / Antigens, CD56
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34. Pamukçuoğlu M, Nasiroğlu N, Yildirim N, Ozçelik O, Oksüzoğlu B, Abali H, Zengin N: [Sinonasal NK/T-cell lymphoma mimicking Wegener's granulomatosis: a case report]. Tuberk Toraks; 2006;54(3):277-80
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  • [Title] [Sinonasal NK/T-cell lymphoma mimicking Wegener's granulomatosis: a case report].
  • [Transliterated title] Wegener granülomatozisi taklit eden sinonazal bölge tutulumlu NK/T-hücreli lenfoma: olgu sunumu.
  • In Western population, sinonasal malignant lymphoma is rare and constitutes 1.5% of all non-Hodgkin lymphoma (NHL) and 2.2% of extranodal lymphomas.
  • Herein, we present a typical WG with isolated sinonasal tract involvement with clinical, and radiological findings with the final diagnosis of NK/T-cell angiocentric lymphoma by the repeated biopsies.
  • Since both diseases have same clinical and radiological findings differential diagnosis may be difficult.
  • [MeSH-major] Granulomatosis with Polyangiitis / diagnosis. Lymphoma, T-Cell / diagnosis. Paranasal Sinus Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans

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  • (PMID = 17001547.001).
  • [ISSN] 0494-1373
  • [Journal-full-title] Tüberküloz ve toraks
  • [ISO-abbreviation] Tuberk Toraks
  • [Language] tur
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Turkey
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35. Gupta T, Wadasadawala T, Shet T, Jalali R, Menon H: Isolated central nervous system involvement by lymphomatoid granulomatosis in an adolescent: a case report and review of literature. Pediatr Hematol Oncol; 2010 Mar;27(2):150-9
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  • Lymphomatoid granulomatosis is an Epstein-Barr virus-associated multisystem disease that combines granulomatous inflammatory process with lymphoproliferative potential.
  • It predominantly affects lungs, skin, and brain and is characterized by multifocal, transmural, angiocentric, and angiodestructive pleomorphic lymphoid infiltrate in a perivascular distribution.
  • Lymphomatoid granulomatosis is generally considered to be a neoplastic B-cell proliferation that has traditionally been associated with poor prognosis, evolving as a progressive multisystem disease transforming into B-cell lymphoma, with a median survival of 14 to 16 months only.
  • The diagnosis of lymphomatoid granulomatosis was confirmed on light microscopy and immunohistochemistry.
  • Awareness of disease spectrum in the central nervous system may permit early diagnosis and thus allow institution of timely appropriate therapy.

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  • (PMID = 20201696.001).
  • [ISSN] 1521-0669
  • [Journal-full-title] Pediatric hematology and oncology
  • [ISO-abbreviation] Pediatr Hematol Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 23
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36. Schubert S, Abdul-Khaliq H, Lehmkuhl HB, Yegitbasi M, Reinke P, Kebelmann-Betzig C, Hauptmann K, Gross-Wieltsch U, Hetzer R, Berger F: Diagnosis and treatment of post-transplantation lymphoproliferative disorder in pediatric heart transplant patients. Pediatr Transplant; 2009 Feb;13(1):54-62
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  • [Title] Diagnosis and treatment of post-transplantation lymphoproliferative disorder in pediatric heart transplant patients.
  • We analyzed the time course of the disease, its severity, the organs involved, and mortality rates in our institutional experience of pediatric heart transplantation.
  • This paper identifies risk factors for PTLD and describes the different ways of diagnosing and treating the disease.
  • It was diagnosed in 7/12 as a monomorphic B-cell lymphoma and in four patients as a monomorphic Burkitt lymphoma, a polymorphic B-cell lymphoma, a T-cell rich or angiocentric lymphoma (Liebow) and as reactive plasmacytic hyperplasia (early lesion), respectively.
  • Despite reduction of immunosuppression, treatment consisted of surgical procedures to remove tumor masses (n = 6), Rituximab (n = 5), polychemotherapy (n = 3), antiviral (n = 1) and autologous T-cell therapy (n = 1).
  • The manifestation of PTLD in pediatric heart transplant recipients is associated with EBV infection and is predominantly in the form of a B-cell lymphoma.
  • [MeSH-major] Heart Transplantation / adverse effects. Lymphoproliferative Disorders / diagnosis


37. Johnson CD, Busaidy KF, Bouquot JE: Oral and maxillofacial pathology case of the month. Angiocentric T-Cell lymphoma (midline lethal granuloma). Tex Dent J; 2007 Aug;124(8):764-5, 772-3
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  • [Title] Oral and maxillofacial pathology case of the month. Angiocentric T-Cell lymphoma (midline lethal granuloma).
  • [MeSH-major] Granuloma, Lethal Midline / pathology. Lymphoma, T-Cell / pathology. Maxillary Neoplasms / pathology. Maxillary Sinus Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Killer Cells, Natural / pathology. Male. Middle Aged. Neoplasm Invasiveness. Nose Neoplasms / pathology. Osteonecrosis / etiology. Osteonecrosis / pathology. Pseudomonas Infections / complications. Pseudomonas Infections / pathology

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  • (PMID = 17867546.001).
  • [ISSN] 0040-4284
  • [Journal-full-title] Texas dental journal
  • [ISO-abbreviation] Tex Dent J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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38. Takiyama A, Nishihara H, Tateishi U, Kimura T, Wang L, Marukawa K, Itoh T, Hashino S, Nagashima K, Tanaka S: CNS lymphomatoid granulomatosis with lymph node and bone marrow involvements. Neuropathology; 2008 Dec;28(6):640-4
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  • Lymphomatoid granulomatosis (LYG) in the CNS is an uncommon lymphoproliferative disease with characteristic angiocentric lymphoreticular proliferative and granulomatous lesions exhibiting low-grade malignant potential.
  • Eight months after the initial neurological symptoms, inguinal lymph node swelling was found and histopathologically diagnosed as peripheral T-cell lymphoma.
  • Considering the clinical course, we concluded lymph node involvement of CNS-LYG, suggesting the malignant potential of CNS-LYG.
  • [MeSH-minor] Cell Nucleus Shape. Gene Rearrangement, T-Lymphocyte. Genes, T-Cell Receptor gamma. Humans. Lymphoma, T-Cell, Peripheral / pathology. Magnetic Resonance Imaging. Male. Middle Aged. Polymerase Chain Reaction. Polymorphism, Single-Stranded Conformational. T-Lymphocytes / immunology. T-Lymphocytes / pathology

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  • [CommentIn] Neuropathology. 2010 Jun;30(3):302; author reply 302-3 [20374496.001]
  • [ErratumIn] Neuropathology. 2009 Aug;29(4):520. Lei, Wang [corrected to Wang, Lei]
  • (PMID = 18410281.001).
  • [ISSN] 1440-1789
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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39. Chorianopoulos D, Samitas K, Vittorakis S, Kiriazi V, Rondoyianni D, Tsaousis G, Skoutelis A: Extranodal natural killer/T-cell lymphoma, nasal-type. Skinmed; 2010 Jan-Feb;8(1):56-8
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  • [Title] Extranodal natural killer/T-cell lymphoma, nasal-type.
  • The differential diagnosis, considering the evidence described, included granulomatous or infectious diseases, angiocentric lymphoproliferative lesions, and lymphomas.
  • Biopsy of a skin lesion showed lymphoproliferative infiltration of the dermis with a follicular and angiocentric growth pattern and regional epidermal necrosis.
  • Immunohistochemical stains showed that the tumor cell were positive for CD56 and CD3 (cytoplasmic positivity) and expressed the cytotoxic proteins T-cell intracellular antigen and granzyme B (Figure 3) They lacked TdT, CD34, CD7, CD8, TCL-1, and CD123.
  • Give this result, molecular analysis ofT-cell receptor (TCR) gene rearrangements was performed using polymerase chain reaction-based TCR-gamma gene, wit negative results.
  • The morphology and the immunophenotype were consistent with natural killer/T-cell lymphoma, nasal-type.
  • Nasal involvement must be first excluded to proceed to the diagnosis of nasal-type natural killer-cell lymphoma.
  • Thus, the authors were led to the diagnosis of extranodal extranasal natural killer/T-cell lymphoma, nasal-type, CD56-positive, Ep stein-Barr virus-negative, TCR-negative.
  • Although the lung lesions had diminished at that time, the patient develope paraplegia, his clinical course rapidly deteriorated, and he eventually died.
  • [MeSH-major] Lymphoma, Extranodal NK-T-Cell / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Fatal Outcome. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 20839428.001).
  • [ISSN] 1540-9740
  • [Journal-full-title] Skinmed
  • [ISO-abbreviation] Skinmed
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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40. Widmer S, Tinguely M, Egli F, Thiel MA: Lethal Epstein-Barr virus associated NK/T-cell lymphoma with primary manifestation in the conjunctiva. Klin Monbl Augenheilkd; 2005 Mar;222(3):255-7
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  • [Title] Lethal Epstein-Barr virus associated NK/T-cell lymphoma with primary manifestation in the conjunctiva.
  • BACKGROUND: Lethal midline granulomas (LMG) are very rare angiocentric NK/T-cell lymphomas in association with Epstein-Barr virus.
  • Conjunctival biopsy revealed a highly malignant, CD3 + and BCL2 + extranodal T-cell lymphoma with features of an NK/T-cell origin (CD56 +, TIA + TCR-rearrangement: germline).
  • All lymphoma cells were positive for Epstein-Barr virus RNA.
  • The patient died within a month because of untreatable pancytopenia due to malignant bone marrow infiltration.
  • CONCLUSIONS: LMG is a rare but highly malignant Epstein-Barr virus associated NK/T-cell lymphoma that can occur in healthy, immune competent Caucasians.
  • [MeSH-major] Conjunctival Neoplasms / diagnosis. Epstein-Barr Virus Infections / diagnosis. Eyelid Neoplasms / diagnosis. Granuloma, Lethal Midline / diagnosis. Killer Cells, Natural / pathology. Lymphoma, T-Cell, Peripheral / diagnosis. T-Lymphocytes / pathology
  • [MeSH-minor] Antigens, CD3 / analysis. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biopsy. Conjunctiva / pathology. Eyelids / pathology. Fatal Outcome. Humans. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / drug therapy. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / radiotherapy. Proto-Oncogene Proteins c-bcl-2 / analysis. Radiotherapy, Adjuvant

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  • (PMID = 15785994.001).
  • [ISSN] 0023-2165
  • [Journal-full-title] Klinische Monatsblätter für Augenheilkunde
  • [ISO-abbreviation] Klin Monbl Augenheilkd
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, CD3; 0 / Proto-Oncogene Proteins c-bcl-2
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41. Choi YL, Park JH, Kim WS, Lee DY, Lee JH, Yang JM, Lee ES: Aggressive NK-cell leukaemia associated with reactive haemophagocytic syndrome. Clin Exp Dermatol; 2006 Jan;31(1):83-5
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  • [Title] Aggressive NK-cell leukaemia associated with reactive haemophagocytic syndrome.
  • We report a case of aggressive NK-cell leukaemia associated with reactive haemophagocytic syndrome in a 29-year-old Korean woman who had several small purpuric patches on both thighs.
  • Skin biopsy from her thigh lesion demonstrated atypical CD56+ lymphoid cellular infiltrates with angiocentric pattern, and in situ hybridization test for Epstein-Barr virus was positive.
  • [MeSH-major] Killer Cells, Natural / immunology. Leukemia / immunology. Lymphohistiocytosis, Hemophagocytic / immunology. Lymphoma, T-Cell, Cutaneous / immunology
  • [MeSH-minor] Adult. Antigens, CD / analysis. Bone Marrow Cells / immunology. Fatal Outcome. Female. Humans. Skin / immunology. Skin / pathology. Thigh

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  • (PMID = 16309492.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD
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42. Chang CH, Hsu YH: Hyper-IgE syndrome with Epstein-Barr virus associated extranodal NK/T cell lymphoma of skin. Kaohsiung J Med Sci; 2010 Apr;26(4):206-10
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  • [Title] Hyper-IgE syndrome with Epstein-Barr virus associated extranodal NK/T cell lymphoma of skin.
  • A skin biopsy showed angiocentric and angiodestructive atypical lymphoid infiltration.
  • In situ hybridization revealed latent Epstein- Barr virus-infected lymphoid cells.
  • Accordingly, this indicates that Epstein-Barr virus infection may have induced the extranodal natural killer/T cell lymphoma in this patient with hyper-IgE syndrome.
  • [MeSH-major] Herpesvirus 4, Human / physiology. Job Syndrome / complications. Job Syndrome / virology. Lymphoma, Extranodal NK-T-Cell / complications. Lymphoma, Extranodal NK-T-Cell / virology. Skin Neoplasms / complications. Skin Neoplasms / virology

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  • [Copyright] Copyright 2010 Elsevier. Published by Elsevier B.V. All rights reserved.
  • (PMID = 20434102.001).
  • [ISSN] 1607-551X
  • [Journal-full-title] The Kaohsiung journal of medical sciences
  • [ISO-abbreviation] Kaohsiung J. Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
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43. Cobo F, Talavera P, Busquier H, Concha A: CNK/T-cell brain lymphoma associated with Epstein-Barr virus in a patient with AIDS. Neuropathology; 2007 Aug;27(4):396-402
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  • [Title] CNK/T-cell brain lymphoma associated with Epstein-Barr virus in a patient with AIDS.
  • We report a case of extranodal NK/T-cell lymphoma, nasal type, with exclusive cerebral localization in a patient with AIDS.
  • The patient presented with neurological alterations, fever and convulsions, so the initial presumptive diagnosis was an opportunistic brain infection.
  • MRI showed a left parietal necrotic lesion and a stereotactic brain biopsy was performed for pathological, microbiological and molecular studies.
  • Histological sections showed an angiocentric and angiodestructive growth pattern and the immunophenotype of this tumor was CD56+, CD45+, CD3+ (cytoplasmic), Granzyme B+ and Perforin+.
  • Also, a rearrangement study showed T-cell gene rearrangement with monoclonal appearance.
  • A diagnosis of extranodal NK/T-cell lymphoma was made and the patient died a few days later.
  • This case represents a very rare example of NK/T-cell lymphoma of the brain in a patient with AIDS.
  • The diagnosis of this kind of lymphomas requires a multimodality approach correlating clinical, morphological, immunophenotypic and molecular data.
  • [MeSH-major] Acquired Immunodeficiency Syndrome / complications. Epstein-Barr Virus Infections / complications. Killer Cells, Natural / pathology. Lymphoma, AIDS-Related / pathology. Lymphoma, T-Cell / pathology
  • [MeSH-minor] AIDS-Related Opportunistic Infections / pathology. Adult. Brain Neoplasms / genetics. Brain Neoplasms / metabolism. Brain Neoplasms / pathology. Brain Neoplasms / virology. Diagnosis, Differential. Gene Rearrangement, T-Lymphocyte. Hepatitis C / complications. Herpesvirus 4, Human / genetics. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Male. Polymerase Chain Reaction


44. Meneses-García A, Herrera J, Mohar A, García-Cuellar C, Súchil-Bernal L: [Metalloproteinase (MMP-1, 2 and 11), tissue inhibitor of metalloproteinase-1 (TIMP-1), and p53 expression in nasal-type angiocentric T/NK-cell lymphoma: an immunohistochemical study]. Gac Med Mex; 2005 Jul-Aug;141(4):291-6
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  • [Title] [Metalloproteinase (MMP-1, 2 and 11), tissue inhibitor of metalloproteinase-1 (TIMP-1), and p53 expression in nasal-type angiocentric T/NK-cell lymphoma: an immunohistochemical study].
  • [Transliterated title] Expresión inmunohistoquímica de metaloproteasas (MMP-1, 2 Y 11) e inhibidor de metaloproteasas de tejido-1 (TIMP-1), y expresión de p53 en linfomas angiocéntricos de células T/NK tipo nasal.
  • Twenty cases of extraganglionar Nasal-type T/NK-cell lymphomas were analyzed at the National Cancer Institute of Mexico.
  • We studied immunophenotype of neoplastic cells, nuclear p53 expression, and enzymes as matrix metalloplroteinases participating in invasion, tissular destruction and metastases.
  • We performed immunohistochemistry to determine CD3, CD56, p53 cellular type and expression of (MMPs-1, 2, 11) matrix metalloproteinases and one tissue inhibitor of TIMP-1 metalloproteinase.
  • Demographic variables included, age, sex, primaony location, clinical stage, treatment and follow-up.
  • STATISTIC ALANALYSIS: The association of different matrix metalloproteinases in epthial and tumoral cells, stroma, necrosis and endothelial cells were found to be significant using Fisher's exact test.
  • RESULTS: All studied cases were positive to cytoplasmic CD3, CD56 (NK cells), 19 of them were positive to p53, five of them with nuclear overexpression of p53 in more than 50% of neoplastic cells.
  • There was significant expression of MMP-1 in tumoral cells; the epithelium displayed significant expression of TIMP-1 and MMP-11.
  • DISCUSSION: This type of lymphoma is a common neoplasm in Asia, Latin America and Mexico.
  • It is worth noting it has has been linked to Epstein-Barr virus with T/NK-cell phenotype, which often displays cellular atypia, an angiocentric growth pattern and necrosis.
  • [MeSH-major] Lymphoma, T-Cell / metabolism. Metalloproteases / metabolism. Nasal Cavity. Nasopharyngeal Neoplasms / metabolism. Nose Neoplasms / metabolism. Tissue Inhibitor of Metalloproteinase-1 / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Data Interpretation, Statistical. Female. Genes, p53. Humans. Immunohistochemistry. Immunophenotyping. Killer Cells, Natural / pathology. Male. Matrix Metalloproteinases. Middle Aged. Palatal Neoplasms / enzymology. Palatal Neoplasms / genetics. Palatal Neoplasms / metabolism. Palatal Neoplasms / pathology. Prognosis. Tumor Suppressor Protein p53

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  • (PMID = 16164124.001).
  • [ISSN] 0016-3813
  • [Journal-full-title] Gaceta médica de México
  • [ISO-abbreviation] Gac Med Mex
  • [Language] spa
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Mexico
  • [Chemical-registry-number] 0 / Tissue Inhibitor of Metalloproteinase-1; 0 / Tumor Suppressor Protein p53; EC 3.4.- / Metalloproteases; EC 3.4.24.- / Matrix Metalloproteinases
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45. Nomura E, Isoda K, Yamanaka K, Yamaguchi M, Hakamada A, Mizutani H: Extra nodal NK/T-cell lymphoma nasal type that responded to DeVIC combination chemotherapy. J Dermatol; 2005 Mar;32(3):204-9
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  • [Title] Extra nodal NK/T-cell lymphoma nasal type that responded to DeVIC combination chemotherapy.
  • We report a 76-year-old woman with extra nodal NK/T-cell lymphoma nasal type (ENKL).
  • The tumor cells showed angiocentric growth with necrosis.
  • Immunohistologically, the tumor cells from the skin lesion expressed CD2, cytoplasmic CD3, CD56, and T-cell intracellular antigen-1 (TIA-1), but not surface CD3, CD19, and TdT.
  • The gastric tumor cell, also expressed cytoplasmic CD3, CD45RO and CD56.
  • After two series of this therapy, no tumors were detected in clinical, histopathological, endoscope and computerized tomogram (CT) examinations.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Lymphoma, T-Cell, Peripheral / pathology. Lymphoma, T-Cell, Peripheral / therapy. Neoplasm Invasiveness / pathology. Skin Neoplasms / pathology. Skin Neoplasms / therapy
  • [MeSH-minor] Aged. Biopsy, Needle. Carboplatin / therapeutic use. Combined Modality Therapy. Dexamethasone / therapeutic use. Disease Progression. Etoposide / therapeutic use. Fatal Outcome. Female. Humans. Ifosfamide / therapeutic use. Immunohistochemistry. Killer Cells, Natural / pathology. Neoplasm Staging. Radiotherapy, Adjuvant

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  • (PMID = 15863868.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 6PLQ3CP4P3 / Etoposide; 7S5I7G3JQL / Dexamethasone; BG3F62OND5 / Carboplatin; UM20QQM95Y / Ifosfamide
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46. Frank MC, Bono E, Sun T: An unusual case of peripheral T-cell lymphoma with CD56 positivity and angiocentric, angiodestructive morphology arising in the ileum. Arch Pathol Lab Med; 2005 Apr;129(4):527-30
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  • [Title] An unusual case of peripheral T-cell lymphoma with CD56 positivity and angiocentric, angiodestructive morphology arising in the ileum.
  • Natural killer cell and cytotoxic T-cell lymphomas are frequently difficult to distinguish because they share many common features, and yet it is important to make an accurate diagnosis because their prognoses differ.
  • We report an unusual case of a white man with a CD56-positive T-cell lymphoma in the ileum.
  • Immunohistochemical staining showed positive reactions to CD3, CD8, CD43, CD45RO, CD56, and T-cell intracellular antigen-1, but negative reactions to CD4, CD5, CD20, CD23, and CD57.
  • The T-cell receptor gamma chain gene was rearranged.
  • According to the World Health Organization classification, the absence of EBV excludes the diagnosis of extranodal natural killer/T-cell lymphoma, nasal type.
  • However, the association of EBV with this lymphoma in white patients is not clear.
  • Therefore, absence of EBV alone does not necessarily exclude nasal-type natural killer/T-cell lymphoma, particularly because the histologic pattern in this case is highly characteristic of this tumor.
  • [MeSH-major] Ileal Neoplasms / pathology. Lymphoma, T-Cell, Peripheral / pathology
  • [MeSH-minor] Aged. Antigens, CD56 / metabolism. Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor. Humans. Immunohistochemistry. Male. Neovascularization, Pathologic

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  • (PMID = 15794680.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD56
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47. Windsor R, Stiller C, Webb D: Peripheral T-cell lymphoma in childhood: population-based experience in the United Kingdom over 20 years. Pediatr Blood Cancer; 2008 Apr;50(4):784-7
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  • [Title] Peripheral T-cell lymphoma in childhood: population-based experience in the United Kingdom over 20 years.
  • BACKGROUND: Peripheral T-cell lymphomas (PTCL) are very rare in children and this has prevented assessment of best treatment and prognosis.
  • Anaplastic large cell lymphoma and mycosis fungoides were excluded due to recent publications describing UK experience with these disorders.
  • RESULTS: Twenty-five cases were identified, comprising 1.6% of non-Hodgkin lymphoma (NHL) registrations; 17 (68%) children with PTCL-unspecified (PTCL-u), 3 (12%) with angiocentric PTCL, 3 (12%) with angioimmunoblastic PTCL, and 2 (8%) with subcutaneous panniculitis-like T-cell lymphoma.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Lymphoma, T-Cell, Peripheral / drug therapy

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 18022899.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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48. Kim Y, Kang MS, Kim CW, Sung R, Ko YH: CD4+CD56+ lineage negative hematopoietic neoplasm: so called blastic NK cell lymphoma. J Korean Med Sci; 2005 Apr;20(2):319-24
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  • [Title] CD4+CD56+ lineage negative hematopoietic neoplasm: so called blastic NK cell lymphoma.
  • Blastic natural killer (NK) cell lymphoma is a rare neoplasm characterized by blastoid tumor cells expressing CD4 and CD56, with predominant skin involvement.
  • Although this tumor has been regarded as a neoplasm related to NK cell, recent studies suggested that it is derived from plasmacytoid dendritic cells, but not from NK cell.
  • Herein we report 4 cases of CD4+CD56+ lineage marker-blastic NK cell lymphomas with a review of literatures.
  • Three patients had skin lesions, at initial presentation in two patients and during the course of disease in other patient.
  • Histologically, tumors consisted of monotonous medium to large blastoid cells showing no necrosis, angiocentric growth or epidermotrophism.
  • Lineage specific markers for B- and T cell were negative.
  • T-cell receptor gene rearrangement, EBV, CD13 and CD33 were negative.
  • In one patient, tumor cells arranged in Homer-Wright type pseudorosette and expressed terminal deoxynucleotidyl transferase(TdT).
  • Despite the standard lymphoma chemotherapy, the tumors, except one lost during follow-up, progressed and relapsed.
  • The patients died 8-60 months after diagnosis.
  • [MeSH-major] Antigens, CD4 / analysis. Antigens, CD56 / analysis. Killer Cells, Natural / pathology. Lymphoma, T-Cell / pathology
  • [MeSH-minor] Adolescent. Cell Lineage. Female. Humans. Male. Middle Aged

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  • (PMID = 15832009.001).
  • [ISSN] 1011-8934
  • [Journal-full-title] Journal of Korean medical science
  • [ISO-abbreviation] J. Korean Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Antigens, CD4; 0 / Antigens, CD56
  • [Other-IDs] NLM/ PMC2808614
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49. Hsieh PP, Tung CL, Chan AB, Liao JB, Wang JS, Tseng HH, Su HH, Chang KC, Chang CC: EBV viral load in tumor tissue is an important prognostic indicator for nasal NK/T-cell lymphoma. Am J Clin Pathol; 2007 Oct;128(4):579-84
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  • [Title] EBV viral load in tumor tissue is an important prognostic indicator for nasal NK/T-cell lymphoma.
  • We retrospectively studied 19 cases of nasal NK/T-cell lymphoma for various potential prognostic factors and performed real-time quantitative polymerase chain reaction for Epstein-Barr virus (EBV) viral load in tumor tissue.
  • Patients with a low EBV viral load (<1 copy per cell) more frequently survived for more than 2 years compared with patients with a high EBV viral load (>/=1 copies/cell) (7/7 vs 3/9; P = .014; Fisher exact test).
  • In contrast, the overall survival of the patients did not correlate with the extent of lesion, age, stage, necrosis, histologic subtypes, CD56 expression, or angiocentric or angiodestructive growth pattern.
  • Our findings suggest that the EBV viral load in tumor tissues is a useful indicator for predicting outcome of nasal NK/T-cell lymphoma.
  • [MeSH-major] Epstein-Barr Virus Infections / virology. Herpesvirus 4, Human / isolation & purification. Killer Cells, Natural / virology. Lymphoma, T-Cell, Peripheral / virology. Nose Neoplasms / virology

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  • (PMID = 17875508.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Viral
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50. Min HS, Hyun CL, Paik JH, Jeon YK, Choi G, Park SH, Seo JW, Kim CW: An autopsy case of aggressive CD30+ extra-nodal NK/T-cell lymphoma initially manifested with granulomatous myositis. Leuk Lymphoma; 2006 Feb;47(2):347-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An autopsy case of aggressive CD30+ extra-nodal NK/T-cell lymphoma initially manifested with granulomatous myositis.
  • This study reports an autopsy case of a 53 year-old male with rapidly progressive extra-nodal NK/T-cell lymphoma accompanied with unusual clinical and pathologic features.
  • He was initially presented with localized swelling and tenderness in the right lower extremity and the biopsy from the calf muscle was interpreted as granulomatous myositis masquerizing lymphoma.
  • The biopsy from erythematous skin lesion of trunk showed infiltration of medium sized atypical lymphoid cells with relatively plump cytoplasm and immunophenotype of CD30+, CD56+/- and surface CD3-, which lead to the diagnosis of CD30+ anaplastic large cell lymphoma.
  • After confirmation of EBV infection, he was finally diagnosed as extra-nodal NK/T-cell lymphoma with peculiar immunophenotype of CD3 dim+ and CD30+.
  • At autopsy, disseminated angiocentric lymphoma was found all over the internal organs including the brain.
  • This case emphasizes that extra-nodal NK/T-cell lymphoma should be considered as a cause of granulomatous myositis and can express CD30 positivity and CD3 weak positivity, which are unusual but rarely predominant feature of NK/T-cell lymphoma.
  • [MeSH-major] Antigens, CD30 / immunology. Granuloma / pathology. Killer Cells, Natural / pathology. Lymphoma, T-Cell / pathology. Myositis / pathology
  • [MeSH-minor] Antigens, CD3 / immunology. Disease Progression. Fatal Outcome. Humans. Immunophenotyping. Male. Middle Aged

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  • (PMID = 16321870.001).
  • [ISSN] 1042-8194
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD3; 0 / Antigens, CD30; 0 / CD3 antigen, zeta chain
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51. Drut R, Drut RM: Angiocentric immunoproliferative lesion and angiocentric lymphoma of lymph node in children. A report of two cases. J Clin Pathol; 2005 May;58(5):550-2
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  • [Title] Angiocentric immunoproliferative lesion and angiocentric lymphoma of lymph node in children. A report of two cases.
  • AIM: To report two examples of an angiocentric immunoproliferative lesion (AIL) and angiocentric angiodestructive lymphoma (AL) presenting in lymph nodes in children.
  • METHODS/RESULTS: Case 1 presented as a cervical lymphadenopathy in a 3 year old girl being treated for pre-B cell acute lymphoblastic leukaemia.
  • Histological and immunohistochemistry studies revealed an Epstein-Barr virus positive (EBV+), large B cell (CD20 and CD30+) AIL with large areas of necrosis, the whole resembling lymphomatoid granulomatosis.
  • Histology and immunohistochemistry revealed an EBV-, large T cell (CD45RO, CD56, and CD30+) AL, presenting the features of so called angiocentric T cell/natural killer cell lymphoma, nasal type.
  • CONCLUSIONS: The term AIL/AL refers to a heterogeneous group of conditions not unique to a particular type of lymphoid cell.
  • These lesions are easily recognised by the histopathologist because of their extremely unusual angiocentric pattern.
  • [MeSH-major] Immunoproliferative Disorders / pathology. Lymph Nodes / pathology. Lymphatic Diseases / pathology. Lymphoma, T-Cell / pathology

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  • (PMID = 15858132.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1770650
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52. Kwong YL: Natural killer-cell malignancies: diagnosis and treatment. Leukemia; 2005 Dec;19(12):2186-94
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Natural killer-cell malignancies: diagnosis and treatment.
  • Natural killer (NK)-cell malignancies are uncommon diseases.
  • Previously known as polymorphic reticulosis or angiocentric T-cell lymphomas, they are classified by the World Health Organization as NK/T-cell lymphoma, nasal type and aggressive NK-cell leukemia.
  • Pathologically, NK-cell lymphomas show a polymorphic neoplastic infiltrate with an angioinvasive and angiodestructive pattern.
  • Lymphoma cells are characteristically CD2+, CD56+ and cytoplasmic CD3epsilon+.
  • T-cell receptor gene is germline, and clonal Epstein-Barr virus (EBV) infection is almost invariably.
  • Clinically, they can be divided into nasal, non-nasal, and aggressive lymphoma/leukemia subtypes.
  • Most nasal NK-cell lymphomas present with stage I/II disease, and frontline radiotherapy is the most important key to successful treatment.
  • Chemotherapy is indicated for advanced nasal NK-cell lymphoma, and the non-nasal and aggressive subtypes.
  • High-dose chemotherapy with hematopoietic stem cell transplantation may be beneficial to selected patients.
  • [MeSH-major] Killer Cells, Natural / pathology. Leukemia. Lymphoma

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  • (PMID = 16179910.001).
  • [ISSN] 0887-6924
  • [Journal-full-title] Leukemia
  • [ISO-abbreviation] Leukemia
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Number-of-references] 83
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