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1. Tang QL, Liu WP, Zhang WY, Yang F, He MX, Xia QJ, Li GD: [Expression of CYR61 and VEGF in extranodal nasal-type NK/T cell lymphoma and their significances]. Zhonghua Xue Ye Xue Za Zhi; 2006 Oct;27(10):661-5
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  • [Title] [Expression of CYR61 and VEGF in extranodal nasal-type NK/T cell lymphoma and their significances].
  • OBJECTIVE: To investigate the expression of CYR61 and VEGF in extranodal nasal-type NK/T cell lymphoma and its significance.
  • METHODS: CYR61 mRNA and VEGF mRNA were detected by real-time fluorescence quantitative PCR method in 20 cases of extranodal nasal-type NK/T cell lymphoma.
  • CONCLUSION: In extranodal nasal-type NK/T cell lymphoma, the expression level of CYR61 and VEGF was changed and it may be of prognostic implication of
  • [MeSH-major] Immediate-Early Proteins / biosynthesis. Intercellular Signaling Peptides and Proteins / biosynthesis. Lymphoma, T-Cell / metabolism. Nose Neoplasms / metabolism. Vascular Endothelial Growth Factor A / biosynthesis
  • [MeSH-minor] Adolescent. Adult. Aged. Cysteine-Rich Protein 61. Female. Humans. Killer Cells, Natural. Male. Middle Aged. Polymerase Chain Reaction. RNA, Messenger / biosynthesis

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  • (PMID = 17343196.001).
  • [ISSN] 0253-2727
  • [Journal-full-title] Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
  • [ISO-abbreviation] Zhonghua Xue Ye Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / CYR61 protein, human; 0 / Cysteine-Rich Protein 61; 0 / Immediate-Early Proteins; 0 / Intercellular Signaling Peptides and Proteins; 0 / RNA, Messenger; 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A
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2. Pol-Rodriguez MM, Fox LP, Sulis ML, Miller IJ, Garzon MC: Extranodal nasal-type natural killer T-cell lymphoma in an adolescent from Bangladesh. J Am Acad Dermatol; 2006 May;54(5 Suppl):S192-7
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  • [Title] Extranodal nasal-type natural killer T-cell lymphoma in an adolescent from Bangladesh.
  • Natural killer (NK)-cell neoplasms are relatively uncommon tumors.
  • Advances in immunohematology over the past 10 years have aided in the recognition and categorization of NK-cell tumors.
  • One type of tumor that belongs to this class is extranodal, nasal-type NK/T-cell lymphoma.
  • These lymphoma cells express a cytotoxic T-cell or NK-cell phenotype, including CD56 and TIA-1.
  • Nasal-type NK/T-cell lymphomas arise from extranasal sites such as the skin and are often associated with Epstein-Barr virus infection.
  • We report a case of an adolescent Bangladeshi boy with extranodal, nasal-type NK/T-cell lymphoma who had cutaneous nodules on the extremities.
  • [MeSH-major] Extremities. Killer Cells, Natural / pathology. Lymphoma, T-Cell / pathology. Skin Neoplasms / pathology

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  • (PMID = 16631938.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD
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3. Zhang YC, Sha Zhao, Yu JB, Lei Shi, He MX, Zhang HY, Liu WP: Gastric involvement of extranodal NK/T-cell lymphoma, nasal type: a report of 3 cases with literature review. Int J Surg Pathol; 2008 Oct;16(4):450-4
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  • [Title] Gastric involvement of extranodal NK/T-cell lymphoma, nasal type: a report of 3 cases with literature review.
  • Gastric involvement of extranodal natural killer/T-cell lymphoma, nasal type is extremely rare, and its clinicopathologic features are also poorly understood.
  • In this article, 3 cases of extranodal natural killer/T-cell lymphoma, nasal type are reported.
  • It is a challenge for pathologist to make the diagnosis for this special type of tumor.
  • In all, 2 of 3 cases had a relevant history of midfacial extranodal natural killer/T-cell lymphoma, nasal type before.
  • [MeSH-major] Lymphoma, Extranodal NK-T-Cell / pathology. Nose Neoplasms / pathology. Stomach Neoplasms / pathology

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  • (PMID = 18492683.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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4. Furuta K, Nakagawa A, Morita K, Tajiri T, Nishiyama H, Nohgawa M, Ono K, Kobashi Y: [A case of lymphomatoid granulomatosis which initially demonstrated a diffuse ground glass appearance]. Nihon Kokyuki Gakkai Zasshi; 2010 Jan;48(1):49-54
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  • Lymphomatoid granulomatosis is defined as an Epstein-Barr virus-associated B-cell lymphoma which possibly progresses to malignant lymphoma.
  • We finally diagnosed lymphomatoid granulomatosis (grade 2) based on the findings of a thoracoscopic lung biopsy.
  • Pathologically, an angiocentric proliferation of large atypical lymphoid cells were observed which were positive for EBER (EBV-encoded small RNA).

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  • (PMID = 20163022.001).
  • [ISSN] 1343-3490
  • [Journal-full-title] Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
  • [ISO-abbreviation] Nihon Kokyuki Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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5. Patel SV, Shende ST, Vedi JN, Wakode PT: Polymorphic reticulosis: A case report. Indian J Otolaryngol Head Neck Surg; 2006 Jul;58(3):306-7
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  • [Title] Polymorphic reticulosis: A case report.
  • A 32 year old male came to us with right sided nasal obstruction, epistaxis and nasal mass.
  • Biopsy confirmed the diagnosis of polymorphic reticulasis. which is infact malignant T cell lymphoma of the sinonasal region.
  • The nasal T cell lymphoma causes slow progressive destructian of nose and midfacial region and still presents a diagnostic problem.
  • The clinical and pathological characteristics and management of sinonasal lymphomas are discussed.

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  • [Cites] Zhonghua Yi Xue Za Zhi (Taipei). 1997 Nov;60(5):236-44 [9509678.001]
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  • (PMID = 23120326.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3450395
  • [Keywords] NOTNLM ; Malignant midline granuloma / Polymorphic reticulosis / T cell lymphomas
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6. Harabuchi Y, Takahara M, Kishibe K, Moriai S, Nagato T, Ishii H: Nasal natural killer (NK)/T-cell lymphoma: clinical, histological, virological, and genetic features. Int J Clin Oncol; 2009 Jun;14(3):181-90
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  • [Title] Nasal natural killer (NK)/T-cell lymphoma: clinical, histological, virological, and genetic features.
  • Nasal natural killer (NK)/T-cell lymphoma (NNKTL) is a clinical illness characterized by progressive unrelenting ulceration and necrosis of the nasal cavity and midline facial tissues.
  • Histological features of the lymphoma include angiocentric and polymorphous lymphoreticular infiltrates, called polymorphic reticulosis.
  • Surface antigens and the NK-cell marker, CD56, as well as pan-T antigen CD2, cytoplasmic CD3 (CD3epsilon), and CD45 are expressed in the lymphoma cells.
  • The origin of the lymphoma is thought to be either NK-cell linkage without T-cell receptor (TCR) rearrangement or gammadeltaT-cell linkage with gammadeltaTCR rearrangement.
  • Since the authors of this study first demonstrated the presence of Epstein Barr virus (EBV)-DNA and EBV oncogenic proteins in NNKTL, the lymphoma has been classified as one of the EBV-associated malignancies.
  • The NNKTL cells produce interleukin (IL)-9, IL-10, and interferon-gamma-inducible protein-10 (IP-10), possibly due to EBV-oncogenic proteins in the lymphoma cells, and such cytokines take an important part in the cell proliferation and invasion, acting in an autocrine manner.
  • Clinically, the serum EBV-DNA copy number is useful as a specific tumor marker and a predictive prognostic factor.
  • Even in early clinical stages, the lymphoma shows poor prognosis caused by the rapid progression of the lesion into distinct organs.
  • In this article, the clinical, pathological, and virological characteristics of the lymphoma are reviewed, along with a report of our investigations.
  • [MeSH-major] Herpesvirus 4, Human / isolation & purification. Killer Cells, Natural / pathology. Lymphoma, T-Cell. Nose Neoplasms

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  • (PMID = 19593607.001).
  • [ISSN] 1341-9625
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Chemokines; 0 / Cytokines
  • [Number-of-references] 65
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7. Peral-Cagigal B, Galdeano-Arenas M, Crespo-Pinilla JI, García-Cantera JM, Sánchez-Cuéllar LA, Verrier-Hernández A: Centrofacial angiocentric lymphoma. Med Oral Patol Oral Cir Bucal; 2005 Jan-Feb;10(1):92-4; 90-2
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  • [Title] Centrofacial angiocentric lymphoma.
  • The centrofacial angiocentric lymphoma is a rare lymphoid neoplasm, with an often-difficult diagnosis due to the non-specific clinical picture.
  • On many occasions it is necessary to perform various biopsies to reach the correct diagnosis.
  • This lymphoma is an aggressive Non-Hodgkin's (NHL) type, which is normally found in the upper respiratory tract (predominantly in the nasal cavity), and has an ominous prognosis, as the average survival rate is between 12 and 18 months (1).
  • This is the case study of a female Ecuadorian patient who was referred to our department with a hemifacial edema, chocolate- like rhinorrhea and nasal respiratory obstruction, which had been treated with antibiotics and anti-inflammatories for a month without success.
  • After performing a number of diagnostic tests, it was found histologically that the patient had an extranodal T-cell lymphoma of the nasal type (also known as T-cell angiocentric lymphoma).
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Lymphoma, T-Cell / diagnosis

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  • (PMID = 15627913.001).
  • [ISSN] 1698-4447
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng; spa
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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8. Yokoyama H, Yamada MF, Ishizawa K, Yamamoto J, Tomiya Y, Harigae H, Kameoka J, Ichinohasama R, Sasaki T: Successful treatment of advanced extranodal NK/T cell lymphoma with unrelated cord blood transplantation. Tohoku J Exp Med; 2007 Apr;211(4):395-9
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  • [Title] Successful treatment of advanced extranodal NK/T cell lymphoma with unrelated cord blood transplantation.
  • Nasal natural killer (NK)/T cell lymphoma is a rare entity of non-Hodgkin's lymphoma which mostly occurs in East Asian countries.
  • The advanced disease above clinical stage III is often refractory to the radiation and chemotherapies, remission is transient even if achieved, and median survival is about 12 months.
  • Thus the prognosis of advanced NK/T cell lymphoma is generally poor, however, the promising results of allogeneic hematopoietic stem cell transplantation for advanced NK/T cell lymphoma have been recently reported.
  • In most of these cases, stem cell sources were human leukocyte antigen (HLA) matched donors and alternative sources were seldom used.
  • We report here a case of a 36-year-old woman who was diagnosed as having an extranodal NK/T cell lymphoma, nasal type.
  • Cord blood thus could be an appropriate stem cell source for patients with advanced NK/T lymphoma who have no HLA matched donors.
  • [MeSH-major] Cord Blood Stem Cell Transplantation. Lymphoma, T-Cell / therapy
  • [MeSH-minor] Adult. Female. Histocompatibility Testing. Humans. Killer Cells, Natural / pathology. Nose Neoplasms / pathology. Nose Neoplasms / therapy. Tissue Donors

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  • (PMID = 17409680.001).
  • [ISSN] 0040-8727
  • [Journal-full-title] The Tohoku journal of experimental medicine
  • [ISO-abbreviation] Tohoku J. Exp. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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9. Nagatani M, Yamakawa S, Ando R, Edamoto H, Saito T, Tamura K: Highly invasive intracranial malignant schwannoma in a rat. J Toxicol Pathol; 2009 Jun;22(2):139-42
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  • [Title] Highly invasive intracranial malignant schwannoma in a rat.
  • A highly invasive intracranial malignant schwannoma containing several masses was detected in a 28-week-old male Crl:CD(SD) rat.
  • Macroscopically, 3 masses were noted in the cranial cavity; one was present at the bottom of the cranial cavity and involved the trigeminal nerve, and the other two were in the parietal bone.
  • In the brain, the tumor cells infiltrated diffusely into the leptomeningeal and perivascular spaces and parenchyma, in which the tumor cell morphology and invasive pattern closely resembled those of malignant astrocytoma and malignant reticulosis.
  • Electron microscopically, a single basal lamina layer and short intricate cell processes were confirmed in the tumor cells.
  • From these results, the present tumor was diagnosed as a malignant schwannoma arising in the cranial cavity, probably originating from the trigeminal nerve.
  • The present tumor is considered to be a relatively unique malignant schwannoma based on its growth and invasion patterns.

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  • (PMID = 22271987.001).
  • [ISSN] 0914-9198
  • [Journal-full-title] Journal of toxicologic pathology
  • [ISO-abbreviation] J Toxicol Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Other-IDs] NLM/ PMC3246059
  • [Keywords] NOTNLM ; cranial cavity / malignant schwannoma / rat / spontaneous
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10. Régis A, Ben Salem D, Lambert A, Couaillier JF, Casasnovas O, Piard F, Krausé D: [Concomitant pulmonary Langerhans cell histiocytosis and malignant lymphoma: report of two cases]. J Radiol; 2009 Jan;90(1 Pt 1):66-8
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  • [Title] [Concomitant pulmonary Langerhans cell histiocytosis and malignant lymphoma: report of two cases].
  • [Transliterated title] Association rare de l'histiocytose Langerhansienne pulmonaire et d'un lymphome malin: à propos de deux cas.
  • [MeSH-major] Histiocytosis, Langerhans-Cell / complications. Hodgkin Disease / complications. Lymphoma, Follicular / complications


11. Zhang XX, Xie CH, Xu Y, Deng D, Zhao YH, Zou BW, Zhou L, Li M, Wang J, Liu WP, Huang MJ: Salvage treatment improved survival of patients with relapsed extranodal natural killer/t-cell lymphoma, nasal type. Int J Radiat Oncol Biol Phys; 2009 Jul 1;74(3):747-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Salvage treatment improved survival of patients with relapsed extranodal natural killer/t-cell lymphoma, nasal type.
  • PURPOSE: To evaluate the clinical outcome of salvage treatment for patients with relapsed natural killer (NK)/T-cell lymphoma, nasal type.
  • CONCLUSIONS: Salvage treatment improved survival in patients with relapsed NK/T-cell lymphoma, nasal type.
  • Salvage RT may play an important role in salvage treatment of relapsed extranodal NK/T-cell lymphoma.
  • [MeSH-major] Lymphoma, Extranodal NK-T-Cell / mortality. Salvage Therapy / mortality

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  • (PMID = 19304409.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 6PLQ3CP4P3 / Etoposide; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CHOP protocol; EPOCH protocol
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12. Omori N, Narai H, Tanaka T, Tanaka S, Yamadori I, Ichimura K, Yoshino T, Abe K, Manabe Y: Epstein-Barr virus-associated T/NK cell-type central nervous system lymphoma which manifested as a post-transplantation lymphoproliferative disorder in a renal transplant recipient. J Neurooncol; 2008 Apr;87(2):189-91
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  • [Title] Epstein-Barr virus-associated T/NK cell-type central nervous system lymphoma which manifested as a post-transplantation lymphoproliferative disorder in a renal transplant recipient.
  • In October 2004, he was admitted to our hospital by ambulance with a clonic seizure and a recurrence of hemiplegia on the right side of his body.
  • A stereotactic brain biopsy was performed, and the pathological diagnosis was nasal type extranodal T/NK cell lymphoma manifested as the post transplant lymphoproliferative disease (PTLD).
  • [MeSH-major] Central Nervous System Neoplasms / etiology. Epstein-Barr Virus Infections / complications. Kidney Transplantation. Lymphoma, T-Cell / etiology. Postoperative Complications
  • [MeSH-minor] Adult. Graft Rejection / prevention & control. Humans. Immunosuppressive Agents / therapeutic use. Killer Cells, Natural / pathology. Magnetic Resonance Imaging. Male. T-Lymphocytes / pathology

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  • (PMID = 18058068.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Immunosuppressive Agents
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13. Suenaga M, Matsushita K, Kawamata N, Kukita T, Hamakawa Y, Gejima K, Onodera R, Sato T, Yamaguchi A, Inoue H, Arimura K, Arima N, Yoshida H, Tei C: True malignant histiocytosis with trisomy 9 following primary mediastinal germ cell tumor. Acta Haematol; 2006;116(1):62-6
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  • [Title] True malignant histiocytosis with trisomy 9 following primary mediastinal germ cell tumor.
  • A diagnosis of mediastinal germ cell tumor, mixed type involving seminoma, immature teratoma and embryonal carcinoma, was made by transthoracic needle biopsy.
  • Examination of bone marrow revealed increased atypical large histiocytes (5.6%) with hemophagocytosis, and thus, hemophagocytic syndrome related to germ cell tumor was diagnosed.
  • Chemotherapies for germ cell tumor and hemophagocytic syndrome were performed without any improvement, and he died of diffuse alveolar damage.
  • The atypical histiocytes were positive for CD68 and lysozyme and negative for lymphoid markers, and the diagnosis of true malignant histiocytosis associated with mediastinal germ cell tumor was made.
  • The rare chromosomal abnormality of trisomy 9, a marker for benzene-related leukemia, was seen in the present case without apparent benzene exposure.
  • [MeSH-major] Chromosomes, Human, Pair 9. Histiocytic Sarcoma / pathology. Lymphohistiocytosis, Hemophagocytic / pathology. Mediastinal Neoplasms / pathology. Neoplasms, Germ Cell and Embryonal / pathology. Neoplasms, Second Primary / pathology. Trisomy

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  • (PMID = 16809892.001).
  • [ISSN] 0001-5792
  • [Journal-full-title] Acta haematologica
  • [ISO-abbreviation] Acta Haematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / CD68 antigen, human; EC 3.2.1.17 / Muramidase
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14. Tardío JC, Moreno A, Pérez C, Hernández-Rivas JA, López-Carreira M: Primary laryngeal T/NK-cell lymphoma, nasal-type: an unusual location for an aggressive subtype of extranodal lymphoma. Eur Arch Otorhinolaryngol; 2008 Jun;265(6):705-8
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  • [Title] Primary laryngeal T/NK-cell lymphoma, nasal-type: an unusual location for an aggressive subtype of extranodal lymphoma.
  • Most of them are extramedullary plasmocytomas, diffuse large B-cell lymphomas, or MALT-type marginal zone B-cell lymphomas.
  • T- or NK-cell lymphomas have rarely been reported in this location.
  • The diagnosis of laryngeal lymphomas is a challenge, due to the absence of clinical and gross differential criteria.
  • We present hereby a primary laryngeal T/NK-cell lymphoma, nasal-type.
  • Polychemotherapy was administrated with initial partial response, but rapid local progression and exitus followed six months after the diagnosis.
  • The extranodal T/NK-cell lymphoma, nasal-type is a very aggressive subtype of extranodal lymphoma, usually located in the nasal cavity or in nearby sites.
  • The prognosis of extranasal cases of this type of lymphoma is poor, even when they are diagnosed in localized stages.
  • [MeSH-major] Killer Cells, Natural / pathology. Laryngeal Neoplasms / diagnosis. Lymphoma, T-Cell, Peripheral / diagnosis
  • [MeSH-minor] Adult. Antineoplastic Agents / therapeutic use. Biopsy. Diagnosis, Differential. Fatal Outcome. Humans. Laryngoscopy. Male. Severity of Illness Index. Tomography, X-Ray Computed

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  • (PMID = 17955253.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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15. Ishida F, Kwong YL: Diagnosis and management of natural killer-cell malignancies. Expert Rev Hematol; 2010 Oct;3(5):593-602
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  • [Title] Diagnosis and management of natural killer-cell malignancies.
  • Natural killer (NK)-cell malignancies are uncommon neoplasms, which have been referred to as polymorphic reticulosis or angiocentric T-cell lymphomas in the past.
  • In the current WHO classification, they are categorized as extranodal NK/T-cell lymphoma, nasal type and aggressive NK-cell leukemia.
  • NK-cell malignancies show a geographical predilection for Asian and South American populations and are rare in the west.
  • Pathologically, NK-cell lymphomas show a polymorphic neoplastic infiltrate with angioinvasion and angiodestruction.
  • The lymphoma cells are CD2(+), cytoplasmic CD3ε(+) and CD56(+), with germline T-cell receptor gene.
  • Clinically, NK-cell lymphomas can be classified into nasal, non-nasal and aggressive lymphoma/leukemia subtypes.
  • Most nasal NK-cell lymphomas present with stage I/II disease.
  • Chemotherapy is indicated for stage III/IV nasal NK-cell lymphoma, and the non-nasal and aggressive subtypes.
  • Recent regimens that incorporate the use of L-asparaginase have resulted in substantial improvements in outcome in high-risk, refractory or relapsed patients.
  • High-dose chemotherapy and hematopoietic stem-cell transplantation with autologous or allogeneic hematopoietic stem cells may be beneficial to selected patients.
  • Prognostication of patients with clinical prognostic models and presentation circulating Epstein-Barr DNA load may be useful in the stratification of patients for various treatment modalities.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Asparaginase / administration & dosage. Killer Cells, Natural / drug effects. Leukemia / diagnosis. Leukemia / therapy. Lymphoma, Extranodal NK-T-Cell / diagnosis. Lymphoma, Extranodal NK-T-Cell / therapy
  • [MeSH-minor] Antigens, CD. Asia / epidemiology. Female. Hematopoietic Stem Cell Transplantation. Herpesvirus 4, Human. Humans. Male. Middle Aged. Prognosis. Recurrence. Severity of Illness Index. South America / epidemiology. Transplantation, Autologous

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  • (PMID = 21083476.001).
  • [ISSN] 1747-4094
  • [Journal-full-title] Expert review of hematology
  • [ISO-abbreviation] Expert Rev Hematol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD; EC 3.5.1.1 / Asparaginase
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16. Borgmann A, Zinn C, Hartmann R, Herold R, Kaatsch P, Escherich G, Möricke A, Henze G, von Stackelberg A, ALL-REZ BFM Study Group: Secondary malignant neoplasms after intensive treatment of relapsed acute lymphoblastic leukaemia in childhood. Eur J Cancer; 2008 Jan;44(2):257-68
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  • [Title] Secondary malignant neoplasms after intensive treatment of relapsed acute lymphoblastic leukaemia in childhood.
  • PURPOSE: To investigate the cumulative incidence of and the risk factors for developing second malignant neoplasms (SMN) in children and adolescents following treatment for relapse of acute lymphocytic leukaemia (ALL).
  • METHODS: Patients (1376) up to 18 years of age with first relapse of non-B-cell ALL were treated and achieved a 2nd complete remission (CR).
  • The incidence of SMN was analysed, correlated with clinical and therapeutic parameters, and compared to the age-specific incidence rates of cancers as cited in German cancer registries.
  • RESULTS: Out of the 1376 patients 21 were diagnosed with SMN including non-lymphoblastic leukaemia/myelodysplastic syndrome (n=6), osteo-/Ewing's-/fibroblastic sarcoma (n=4), B-cell ALL/lymphoma (n=2), thyroid carcinoma (n=2), basal cell carcinoma, adeno carcinoma, squamous cell carcinoma, meningioma, malignant histiocytosis, glioblastoma and anaplastic astrocytoma (n=1 each).
  • SMN was found to be significantly associated with stem cell transplantation (SCT), and high cumulative doses of cranial irradiation, etoposide and cyclophosphamide.
  • CONCLUSIONS: Despite repeated exposure to intense frontline and relapse treatment (including multiagent chemotherapy, cranial irradiation and stem cell transplantation in some patients) the cumulative incidence of SMN was unexpectedly low, though significantly higher than in the general age-matched population.
  • [MeSH-major] Neoplasms, Second Primary / epidemiology. Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy

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  • (PMID = 17981026.001).
  • [ISSN] 0959-8049
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Investigator] Mertens R; Imbach P; Pongratz E; Rupprecht T; Henze G; Wickmann L; Otte J; Bode U; Eberl W; Pekrun A; Kirschstein M; Hofmann K; Frank R; Möbius D; Andler W; Niekrens C; Breu H; Suttorp M; Göbel U; Weinmann G; Sauerbrey A; Beck JF; Janka-Schaub G; Welte K; Kulozik A; Tautz C; Graf N; Fink FM; Zintl F; Hermann J; Rupprath G; Dupuis W; Rodehüser M; Schrappe M; Berthold F; Sternschulte W; Körholz D; Schmitt K; Selle B; Gutjahr P; Dürken M; Christiansen H; Rose M; Borkhardt A; Burdach S; Jürgens H; Scheurlen W; Eggers G; Geib R; Dickerhoff R; Bielack S; Rauh W; Niethammer D; Debatin KM; Gadner H; Dohrn B; Schlegel PG; Niggli F
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17. Tiodorović J, Lazarević V, Binić I, Tiodorović-Zivković D: Nasal-type NK/T-cell lymphoma: a case report. Acta Dermatovenerol Alp Pannonica Adriat; 2007 Jun;16(2):73-6
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  • [Title] Nasal-type NK/T-cell lymphoma: a case report.
  • Extranodal NK/T-cell lymphoma represents less than 1% of all lymphomas, but is more common in Asia and South America.
  • Two nodules were taken for biopsy, which showed atypical lymphoid cells with angiocentric growth pattern.
  • The immunophenotype of the tumor cells was CD45RO +, CD56 +, CD3 + (epsilon chain), CD20-, consistent with the diagnosis of NK/T-cell lymphoma.
  • NK/T-cell lymphomas are rare and the optimal treatment has not been clearly established.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Lymphoma, Extranodal NK-T-Cell / pathology. Scalp / pathology. Skin Neoplasms / pathology

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  • (PMID = 17992462.001).
  • [ISSN] 1318-4458
  • [Journal-full-title] Acta dermatovenerologica Alpina, Pannonica, et Adriatica
  • [ISO-abbreviation] Acta Dermatovenerol Alp Pannonica Adriat
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Slovenia
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18. Watanabe T, Kinoshita T, Itoh K, Yoshimura K, Ogura M, Kagami Y, Yamaguchi M, Kurosawa M, Tsukasaki K, Kasai M, Tobinai K, Kaba H, Mukai K, Nakamura S, Ohshima K, Hotta T, Shimoyama M: Pretreatment total serum protein is a significant prognostic factor for the outcome of patients with peripheral T/natural killer-cell lymphomas. Leuk Lymphoma; 2010 May;51(5):813-21
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  • [Title] Pretreatment total serum protein is a significant prognostic factor for the outcome of patients with peripheral T/natural killer-cell lymphomas.
  • Peripheral T- and NK-cell lymphomas (PT/NKCLs) are relatively rare, and few studies have validated the International Prognostic Index (IPI) for PT/NKCLs in prospective clinical trials.
  • In a univariate analysis, low total serum protein (TP) and albumin levels, gastrointestinal tract involvement, and histologic subtype (extranodal NK/T-cell lymphoma, nasal type, and peripheral T-cell lymphoma, unspecified) were significantly associated with reduced survival.
  • [MeSH-major] Biomarkers, Tumor / blood. Blood Proteins / metabolism. Lymphoma, Extranodal NK-T-Cell / blood. Lymphoma, Large B-Cell, Diffuse / blood. Lymphoma, T-Cell, Peripheral / blood
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Female. Humans. Killer Cells, Natural / drug effects. Killer Cells, Natural / pathology. Male. Middle Aged. Prospective Studies. Retrospective Studies. Survival Rate. Treatment Outcome

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  • (PMID = 20367565.001).
  • [ISSN] 1029-2403
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Blood Proteins
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19. Ferry JA, Fung CY, Zukerberg L, Lucarelli MJ, Hasserjian RP, Preffer FI, Harris NL: Lymphoma of the ocular adnexa: A study of 353 cases. Am J Surg Pathol; 2007 Feb;31(2):170-84
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  • [Title] Lymphoma of the ocular adnexa: A study of 353 cases.
  • We studied the cases of 353 patients with lymphoma involving the ocular adnexa diagnosed at the Massachusetts General Hospital between 1974 and 2005.
  • In 277 cases, there was no known history of lymphoma.
  • Seventy-six patients had a history of lymphoma, with the ocular adnexa being involved at relapse or with progression of the previously diagnosed lymphoma.
  • The patients had marginal zone lymphoma (182 cases), follicular lymphoma (80 cases), mantle cell lymphoma (18 cases), small lymphocytic lymphoma/chronic lymphocytic leukemia (13 cases), lymphoplasmacytic lymphoma (4 cases), splenic marginal zone lymphoma (2 cases), low-grade B cell, not subclassified (19 cases), precursor B lymphoblastic lymphoma (3 cases), diffuse large B-cell lymphoma (26 cases), and 1 case each of high-grade B-cell lymphoma, not subclassified, peripheral T-cell lymphoma, unspecified type, extranodal NK/T-cell lymphoma, nasal type, and Hodgkin lymphoma, nodular sclerosis type.
  • Almost all marginal zone lymphoma patients (168 of 182, 92%) had primary ocular adnexal lymphoma.
  • Fourteen marginal zone lymphoma patients (8%) had a prior history of lymphoma, usually arising in another extranodal site.
  • Twenty-five of 80 (31%) follicular lymphoma patients had a prior history of lymphoma, usually arising in lymph nodes.
  • Patients with mantle cell lymphoma, chronic lymphocytic leukemia, lymphoplasmacytic lymphoma, and splenic marginal zone lymphoma almost always had a prior history of lymphoma or were known to have widespread disease at the time of diagnosis of ocular adnexal lymphoma.
  • A subset of the diffuse large B-cell lymphomas were associated with large destructive masses involving adjacent structures such as paranasal sinuses, raising the possibility that they may have arisen from one of the adjacent structures and involved the ocular adnexa by direct extension.
  • The relatively high proportion of low-grade lymphoma, not subclassified, highlights the difficulty that may arise in distinguishing different types of low-grade lymphoma, particularly when biopsies are small and artifactually distorted.
  • Ocular adnexal lymphoma is primarily a disease of older adults, with a slight female preponderance.
  • Most lymphomas are low-grade B-cell lymphomas, with marginal zone lymphoma being by far the most common type.
  • Marginal zone lymphoma typically involves the ocular adnexa primarily, whereas other types of low-grade B-cell lymphoma often involve the ocular adnexa secondarily.
  • High-grade B-cell lymphomas only occasionally involve the ocular adnexa, and T-cell lymphoma, NK-cell lymphoma, and Hodgkin lymphoma are only rarely encountered in this site.
  • [MeSH-major] Conjunctival Neoplasms / pathology. Eye Neoplasms / pathology. Lacrimal Apparatus Diseases / pathology. Lymphoma / pathology. Orbital Neoplasms / pathology

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  • (PMID = 17255761.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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20. Nava VE, Sartorelli JS, Ozdemirli M: Maxillary angiocentric EBV-associated large B cell lymphoma associated with methotrexate treatment. J Oral Maxillofac Surg; 2008 Jul;66(7):1557-8
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  • [Title] Maxillary angiocentric EBV-associated large B cell lymphoma associated with methotrexate treatment.
  • [MeSH-major] Antirheumatic Agents / adverse effects. Lymphoma, B-Cell / chemically induced. Lymphoma, Large B-Cell, Diffuse / chemically induced. Maxillary Neoplasms / chemically induced. Methotrexate / adverse effects

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  • [CommentOn] J Oral Maxillofac Surg. 2006 Apr;64(4):708-11 [16546655.001]
  • (PMID = 18571052.001).
  • [ISSN] 1531-5053
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antirheumatic Agents; YL5FZ2Y5U1 / Methotrexate
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21. Berk V, Yildiz R, Akdemir UO, Akyurek N, Karabacak NI, Coskun U, Benekli M: Disseminated extranodal NK/T-cell lymphoma, nasal type, with multiple subcutaneous nodules: utility of 18F-FDG PET in staging. Clin Nucl Med; 2008 May;33(5):365-6
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  • [Title] Disseminated extranodal NK/T-cell lymphoma, nasal type, with multiple subcutaneous nodules: utility of 18F-FDG PET in staging.
  • A 49-year-old man presented with a left nasal cavity mass, biopsy of which revealed extranodal NK/T cell lymphoma.
  • A PET-CT scan showed increased F-18 FDG uptake in the nasal mass, anterior mediastinal lymph nodes, and multiple subcutaneous nodular deposits in the chest wall, gluteal region, and right femoral areas.
  • There is limited literature data on the use of the PET scan in the diagnosis and staging of extranodal nasal NK/T-cell lymphomas.
  • [MeSH-major] Fluorodeoxyglucose F18. Lymphoma, Extranodal NK-T-Cell / radionuclide imaging. Nose Neoplasms / radionuclide imaging. Positron-Emission Tomography / methods. Skin Neoplasms / radionuclide imaging

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  • (PMID = 18431160.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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22. Nagatani M, Ando R, Yamakawa S, Saito T, Tamura K: Histological and immunohistochemical studies on spontaneous rat astrocytomas and malignant reticulosis. Toxicol Pathol; 2009 Aug;37(5):599-605
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  • [Title] Histological and immunohistochemical studies on spontaneous rat astrocytomas and malignant reticulosis.
  • Among spontaneous neoplasms of the rat central nervous system, the discrimination between astrocytoma and malignant reticulosis (MR) is sometimes difficult because of their similar cell morphology and infiltration patterns.
  • These cases were diagnosed as benign/malignant astrocytoma containing no neoplastic oligodendroglial elements or MR according to the diagnostic criteria of the World Health Organization International Classification of Rodent Tumors (Mohr et al. 1994).
  • From the results of morphological and immunohistochemical examinations, it was indicated that there are no distinctive differences between spontaneous astrocytomas and MR in rats, and they are probably derived from the same cell lineage, that is, microglia, macrophage, or radial glia.

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  • (PMID = 19487256.001).
  • [ISSN] 1533-1601
  • [Journal-full-title] Toxicologic pathology
  • [ISO-abbreviation] Toxicol Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Nerve Tissue Proteins; 0 / Vimentin
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23. Kanitsap N, Warnnissorn N: NK/T cell lymphoma, nasal type with sinonasal mass and palatal ulcer: a clinical case report and review of treatment. J Med Assoc Thai; 2010 Dec;93 Suppl 7:S294-8
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  • [Title] NK/T cell lymphoma, nasal type with sinonasal mass and palatal ulcer: a clinical case report and review of treatment.
  • Extranodal Nasal NK/T cell lymphoma, relatively uncommon type of non-Hodgkin's lymphoma, is highly aggressive disease with poor outcomes.
  • We reported a 45-year-old woman with extranodal nasal type NK/T cell lymphoma.
  • The patient presented with chronic nasal stuffiness and mucous bloody discharge.
  • The nasal mass is extensively involved periorbital and sinonasal soft tissue.
  • The salvage chemotherapy was given and the treatment of NK/T cell lymphoma from other reports and literatures were reviewed.
  • [MeSH-major] Killer Cells, Natural / pathology. Nose Neoplasms / pathology. Oral Ulcer / radiography. Salvage Therapy

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  • (PMID = 21294428.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Thailand
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24. Arikan OK, Muluk NB, Atasoy P: Primary nasal-type natural killer/T-cell lymphoma of pterygopalatine fossa. J Craniofac Surg; 2010 Mar;21(2):444-7
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  • [Title] Primary nasal-type natural killer/T-cell lymphoma of pterygopalatine fossa.
  • In this paper, the case of a 69-year-old woman who complained of a 2-month history of headache, extending to the left part of the face, teeth, and shoulder, is reported.
  • She had undergone right total mastectomy and axillar dissection of a spindle cell-type metaplastic carcinoma of the breast 1 year ago.
  • Pathologic examination of the biopsy specimen of the mass revealed a nasal-type extranodal natural killer/T-cell lymphoma with CD45 and intense CD56 staining.
  • Our case shows that a nasal-type extranodal natural killer/T-cell lymphoma should be thought in mind for the differential diagnosis of primary tumors of the pterygopalatine fossa.
  • [MeSH-major] Lymphoma, Extranodal NK-T-Cell / diagnosis. Neoplasms, Second Primary / diagnosis. Nose Neoplasms / diagnosis. Pterygopalatine Fossa / pathology. Skull Neoplasms / diagnosis
  • [MeSH-minor] Aged. Biopsy. Breast Neoplasms / surgery. Carcinoma / surgery. Chemotherapy, Adjuvant. Diagnosis, Differential. Female. Humans. Lymph Node Excision. Magnetic Resonance Imaging. Mastectomy, Simple. Neoadjuvant Therapy. Tomography, X-Ray Computed

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  • (PMID = 20216452.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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25. Li L, Liu YH, Zhuang HG, Luo XL, Zhang F, Xu FP, Luo DL: [Extranodal nasal type NK/T-cell lymphoma: clinicopathologic and prognostic study of 55 cases]. Zhonghua Bing Li Xue Za Zhi; 2009 Apr;38(4):237-42
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  • [Title] [Extranodal nasal type NK/T-cell lymphoma: clinicopathologic and prognostic study of 55 cases].
  • OBJECTIVE: To study the clinicopathologic features and prognostic factors of extranodal nasal type NK/T-cell lymphoma (EN-NK/TCL) in Chinese patients.
  • METHODS: Fifty-five cases of EN-NK/TCL diagnosed in Chinese patients during the period from 1998 to 2007 were studied by light microscopy, immunohistochemistry and in-situ hybridization.
  • The commonest sites of involvement included nasal cavity and adjoining tissue (85.5%).
  • Histologically, EN-NK/TCL was composed of small to medium-sized lymphoid cells.
  • Angiocentric and angiodestructive growth patterns, coagulative tumor necrosis and apoptotic bodies were frequently observed.
  • Immunohistochemical study showed that CD20, the B-cell marker, was negative in all cases.
  • The positivity rates for T-cell markers CD3epsilon, CD4, CD5 and CD8 were 100% (49/49), 7% (3/46), 8% (4/48) and 63% (29/46), respectively.
  • Most cases were also positive for NK-cell marker CD56 (79% 42/53).
  • There was a significant positive correlation between the bcl-2 positive expression and a high Ki-67 expression level.
  • Amongst the 41 cases with clinical information available, 63.4% presented with Ann Arbor stage I to II.
  • CONCLUSIONS: EN-NK/TCL is a mature T-cell and NK-cell neoplasm which can be accurately diagnosed by histologic examination, immunohistochemical study and in-situ hybridization.
  • [MeSH-major] Antigens, CD3 / metabolism. Epstein-Barr Virus Infections. Herpesvirus 4, Human. Lymphoma, Extranodal NK-T-Cell. Nose Neoplasms

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  • (PMID = 19575894.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD3; 0 / Antigens, CD56; 0 / CD3E protein, human; 0 / Ki-67 Antigen; 0 / Poly(A)-Binding Proteins; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / RNA, Viral; 0 / TIA1 protein, human; EC 3.4.21.- / Granzymes
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26. Qin W, Yin Z, Madge SN: Acute presentation of nasal-type natural killer/T-cell lymphoma of the orbit. Eur J Ophthalmol; 2009 Jul-Aug;19(4):679-82
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  • [Title] Acute presentation of nasal-type natural killer/T-cell lymphoma of the orbit.
  • PURPOSE: An unusual case of nasal-type natural killer/T-cell lymphoma (NKTL) of the orbit is reported.
  • METHODS: The clinical history, computed tomography, magnetic resonance imaging, and biopsy specimen of a 29-year-old man with a right orbital lymphoma were evaluated.
  • Orbital biopsy revealed angiodestruction with prominent necrosis, and angiocentric lymphoma growth and lymphoma cells were positively stained for CD3, CD20, CD45RO, CD56, cytotoxic molecules (granzyme B and T-cell intracellular antigen-1), and Epstein-Barr virus.
  • [MeSH-major] Killer Cells, Natural / pathology. Lymphoma, T-Cell / diagnosis. Orbital Neoplasms / diagnosis
  • [MeSH-minor] Adult. Antigens, CD / analysis. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / analysis. Conjunctival Diseases / diagnosis. Cyclophosphamide / therapeutic use. Doxorubicin / therapeutic use. Exophthalmos / diagnosis. Glucocorticoids / therapeutic use. Humans. Magnetic Resonance Imaging. Male. Prednisone / therapeutic use. Tomography, X-Ray Computed. Vincristine / therapeutic use. Vision Disorders / diagnosis

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  • (PMID = 19551687.001).
  • [ISSN] 1120-6721
  • [Journal-full-title] European journal of ophthalmology
  • [ISO-abbreviation] Eur J Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Biomarkers, Tumor; 0 / Glucocorticoids; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CHOP protocol
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27. Wong T, Ko JY, Wang FS, Chen YJ, Ma MC: Epstein-Barr virus associated extranodal natural killer T cell lymphoma of nasal type mimicking pyogenic osteomyelitis of the proximal humerus. Chang Gung Med J; 2008 May-Jun;31(3):314-9
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  • [Title] Epstein-Barr virus associated extranodal natural killer T cell lymphoma of nasal type mimicking pyogenic osteomyelitis of the proximal humerus.
  • Extranodal natural killer (NK) cell lymphoma/leukemia, nasal type, is rare but highly aggressive.
  • We report a male patient who suffered from EBV associated NK/T cell lymphoma of the proximal humerus but presented as pyogenic osteomyelitis with the clinical signs and symptoms of fever, local erythema, elevated erythrocyte sedimation rate and C-reactive protein.
  • The patient was treated using antibiotic therapy but the clinical course did not improve until the initiation of systemic chemotherapy.
  • The patient developed tumor recurrence and died due to pneumonia and respiratory failure 10 months after the initial diagnosis.
  • The purpose of this case report was to emphasize the unusual presentation of a neoplasm mimicking osteomyelitis.
  • [MeSH-major] Epstein-Barr Virus Infections / complications. Humerus. Lymphoma, Extranodal NK-T-Cell / diagnosis. Osteomyelitis / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male. Suppuration

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  • (PMID = 18782956.001).
  • [ISSN] 2072-0939
  • [Journal-full-title] Chang Gung medical journal
  • [ISO-abbreviation] Chang Gung Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
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28. Nigidie A, Schneider J: Nasal NK/T-cell lymphoma causing diagnostic difficulties. Ethiop Med J; 2005 Jul;43(3):197-201
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  • [Title] Nasal NK/T-cell lymphoma causing diagnostic difficulties.
  • We present history, clinical presentation and anatomo-pathologic findings of a 24-year-old female patient with a nasal NK/T-cell lymphoma.
  • This rare tumor is characterized by its angiocentric and angiodestructive growth, which results in extensive tumor necrosis.
  • However, this necrosis is a key feature: it is the result of the capacity of neoplastic NK/T-cells to invade vessels.
  • The T-cell character of the neoplastic lymphoid has been shown by immunohistochemitry.
  • [MeSH-major] Granuloma, Lethal Midline / diagnosis. Killer Cells, Natural. Lymphoma, T-Cell / diagnosis. Nose / physiopathology. Nose Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Fatal Outcome. Female. Humans

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  • (PMID = 16370552.001).
  • [ISSN] 0014-1755
  • [Journal-full-title] Ethiopian medical journal
  • [ISO-abbreviation] Ethiop. Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Ethiopia
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29. Xiao J, Wang SS, Huang Y, Chen LK, Guan ZZ, Huang HQ, Xia ZJ, Xu RH, Lin TY: [Prognostic analysis of 62 cases of nasal NK/T-cell lymphoma]. Ai Zheng; 2006 Sep;25(9):1173-7
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  • [Title] [Prognostic analysis of 62 cases of nasal NK/T-cell lymphoma].
  • BACKGROUND & OBJECTIVE: Extranodal NK/T-cell lymphoma of nasal type (ENKTL) is a rare disease entity with unique biological behavior, of which definitive characteristics are still unknown.
  • This study was to investigate the clinical features and prognostic factors of ENKTL in the population of southern China.
  • Detailed clinical and laboratory data were included in univariate analysis, and statistically significant factors in univariate analysis were then included in multivariate analysis.
  • [MeSH-major] Killer Cells, Natural. Lymphoma, T-Cell / therapy. Nose Neoplasms / therapy

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  • (PMID = 16965665.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Hemoglobins; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CHOP protocol
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30. Yokoyama H, Yamamoto J, Tohmiya Y, Yamada MF, Ohguchi H, Ohnishi Y, Okitsu Y, Fukuhara N, Ohba-Ohtsuka R, Kohata K, Ishizawa K, Kameoka J, Harigae H: Allogeneic hematopoietic stem cell transplant following chemotherapy containing l-asparaginase as a promising treatment for patients with relapsed or refractory extranodal natural killer/T cell lymphoma, nasal type. Leuk Lymphoma; 2010 Aug;51(8):1509-12
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  • [Title] Allogeneic hematopoietic stem cell transplant following chemotherapy containing l-asparaginase as a promising treatment for patients with relapsed or refractory extranodal natural killer/T cell lymphoma, nasal type.
  • The prognosis of advanced extranodal NK/T cell lymphoma (ENKTL) is poor.
  • Allogeneic hematopoietic stem cell transplant (allo-HSCT) has been suggested to be a promising treatment for this disease, but its utility has yet to be established.
  • [MeSH-major] Asparaginase / therapeutic use. Drug Resistance, Neoplasm. Graft vs Host Disease / prevention & control. Hematopoietic Stem Cell Transplantation. Lymphoma, T-Cell / therapy. Natural Killer T-Cells / pathology. Nose Neoplasms / therapy

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  • (PMID = 20496989.001).
  • [ISSN] 1029-2403
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Immunosuppressive Agents; 83HN0GTJ6D / Cyclosporine; EC 3.5.1.1 / Asparaginase; YL5FZ2Y5U1 / Methotrexate
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31. Shim SJ, Yang WI, Shin E, Koom WS, Kim YB, Cho JH, Suh CO, Kim JH, Kim GE: Clinical significance of cyclooxygenase-2 expression in extranodal natural killer (NK)/T-cell lymphoma, nasal type. Int J Radiat Oncol Biol Phys; 2007 Jan 1;67(1):31-8
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  • [Title] Clinical significance of cyclooxygenase-2 expression in extranodal natural killer (NK)/T-cell lymphoma, nasal type.
  • PURPOSE: To determine whether there are any differences in therapeutic response, patterns of systemic recurrence, and prognosis of patients with extranodal natural killer (NK)/T-cell lymphoma, nasal type, by the cyclooxygenase-2 (COX-2) expression.
  • PATIENTS AND METHODS: Thirty-four patients with Ann Arbor Stage I and II extranodal NK/T-cell lymphoma who underwent chemotherapy or radiotherapy, or both, were retrospectively reviewed.
  • These patients were divided into two groups according to their immunohistochemical staining for COX-2 expressions: a COX-2-negative group (n = 10 patients) and a COX-2-positive group (n = 24 patients).
  • RESULTS: There was no significant difference in the clinical profiles between the COX-2-negative and COX-2-positive groups.
  • Compared with the patients in the COX-2-negative group, those in the COX-2-positive group had a significantly lower 2-year systemic recurrence-free survival rate (100% for the COX-2-negative group vs. 54% for the COX-2-positive group) (p = 0.02) and a decreased 5-year overall survival rate (70% for the COX-2-negative group vs. 32% for the COX-2-positive group) (p = 0.06).
  • CONCLUSION: Cyclooxygenase-2 expression can serve as a predictive factor for poor treatment response, higher systemic recurrence, and unfavorable prognosis in patients with extranodal NK/T-cell lymphoma, nasal type.
  • [MeSH-major] Cyclooxygenase 2 / metabolism. Head and Neck Neoplasms / metabolism. Lymphoma, T-Cell / metabolism. Neoplasm Proteins / metabolism

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  • (PMID = 17049184.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Neoplasm Proteins; EC 1.14.99.1 / Cyclooxygenase 2
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32. Liang Q, Ye ZY, Su ZL, Lin HL, Shao CK, Lin SX, Rao HL, Mei KY, Zhao T, Liu YH, Luo DL, Zhu MG, Chen SH, Lin TY: [Clinicopathologic study of 963 cases of mature T-cell and natural killer/T-cell lymphoma with respect to 2008 WHO classification of lymphoid neoplasms]. Zhonghua Bing Li Xue Za Zhi; 2010 May;39(5):291-5
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  • [Title] [Clinicopathologic study of 963 cases of mature T-cell and natural killer/T-cell lymphoma with respect to 2008 WHO classification of lymphoid neoplasms].
  • OBJECTIVE: To study the clinicopathologic features of various types of mature T-cell and natural killer (NK)/T-cell lymphoma in Guangdong, China, with respect to the 2008 WHO classification of lymphoid neoplasms.
  • METHODS: Eleven hundred and thirty-seven (1137) cases of mature T-cell or NK/T-cell lymphoma diagnosed during the period from 2002 to 2006 in Guangzhou area were retrieved.
  • The clinical data, histologic features and immunohistochemical findings were reviewed by a panel of experienced hematopathologists.
  • The cases were re-classified according to the 2008 WHO classification of lymphoid neoplasms.
  • RESULTS: Nine hundred and sixty-three (963) cases fulfilled the diagnostic criteria of mature T-cell or NK/T-cell lymphoma and accounted for 20.1% of all cases of lymphoma encountered during the same period (963/4801).
  • A predominance of extranodal involvement was noted in 644 cases (66.9%), while 319 cases (33.1%) showed mainly nodal disease.
  • The prevalence of various lymphoma subtypes was as follows: peripheral T-cell lymphoma, unspecified (PTCL, NOS) 293 cases (30.4%), extranodal NK/T-cell lymphoma, nasal type 281 cases (29.2%), anaplastic large cell lymphoma (ALCL) 198 cases (20.6%), and angioimmunoblastic T-cell lymphoma (AILT) 46 cases (4.8%).
  • The median age of the patients was 44 years, with the peak age of PTCL, NOS, extranodal NK/T-cell lymphoma, nasal type and AILT being 55 to 64 years, 25 to 54 years and 65 to 74 years, respectively.
  • CONCLUSIONS: Extranodal lesions predominate in mature T-cell and NK/T-cell lymphomas occurring in Guangzhou area.
  • The most common subtype was PTCL, NOS, followed by extranodal NK/T-cell lymphoma, nasal type, ALCL and AILT.
  • The relatively frequent occurrence of extranodal NK/T-cell lymphoma, nasal type in Guangdong area is likely associated with the high incidence of Epstein-Barr virus infection there.
  • [MeSH-major] Lymphoma, Extranodal NK-T-Cell / pathology. Lymphoma, Large-Cell, Anaplastic / pathology. Lymphoma, T-Cell / classification. Lymphoma, T-Cell / pathology. Lymphoma, T-Cell, Peripheral / pathology

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  • (PMID = 20654150.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / Receptor Protein-Tyrosine Kinases; EC 2.7.10.1 / anaplastic lymphoma kinase
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33. Xue LJ, Mao XB, Liu XB, Su QS, Yu HJ, Yang JH: Rapid Remission in Peripheral T-Cell Lymphoma of the Nasal Type by the Bortezomib plus CHOP Therapy. Case Rep Med; 2010;2010:403237
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  • [Title] Rapid Remission in Peripheral T-Cell Lymphoma of the Nasal Type by the Bortezomib plus CHOP Therapy.
  • Peripheral T-cell lymphoma (PTCL) is rare and difficult to treat for its high relapse rate.
  • The authors report a case of PTCL of the skin, regarding which clinical and pathological features, treatment, and prognosis were discussed.
  • Surgical resection of right leg lesion and biopsy of enlarged inguinal lymph nodes histologically indicated a PTCL of the nasal type.

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  • (PMID = 21209804.001).
  • [ISSN] 1687-9635
  • [Journal-full-title] Case reports in medicine
  • [ISO-abbreviation] Case Rep Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3014791
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34. Kishimoto K, Kitamura T, Hirayama Y, Tate G, Mitsuya T: Three cases of extranodal NK/T-cell lymphoma of the nasal type diagnosed by nasal brush cytology. Diagn Cytopathol; 2007 Feb;35(2):125-9
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  • [Title] Three cases of extranodal NK/T-cell lymphoma of the nasal type diagnosed by nasal brush cytology.
  • Extranodal natural killer (NK)/T-cell lymphoma of the nasal type is a rare type of malignant lymphoma that is most common in Asian countries.
  • Here we describe cytomorphologic, immunocytochemical, and molecular cytochemical features of three cases of NK/T-cell lymphoma of the nasal type diagnosed by nasal brush cytology.
  • Cytomorphologic findings common among the three cases included the presence of several cell types, including nasal cavity epithelial cells, histiocytes, phagocytic histiocytes, and lymphoid cells, within a necrotic background.
  • Suspected lymphoma cells were medium to large lymphoid cells possessing light blue and abundant cytoplasm.
  • We believe these intriguing cytologic findings are indicators of NK/T-cell lymphoma of the nasal type.
  • Immunocytochemical and molecular cytochemical analyses showed staining for natural killer cell antigen CD56 as well as cytotoxic granule-associated proteins granzyme B7 (GrB7) and T-cell-restricted intercellular antigen-1 (TIA-1).
  • Comparison between cytobrush and cotton swab methodology showed that cytobrush resulted in more cell-rich specimens than did cotton swabs, suggesting that nasal brush cytology with cytobrush is most useful in the diagnosis of NK/T-cell lymphoma of the nasal type.
  • [MeSH-major] Killer Cells, Natural / pathology. Lymphoma, T-Cell / diagnosis. Nose Neoplasms / diagnosis

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  • (PMID = 17230578.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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35. Lee J, Park YH, Kim WS, Lee SS, Ryoo BY, Yang SH, Park KW, Kang JH, Park JO, Lee SH, Kim K, Jung CW, Park YS, Im YH, Kang WK, Lee MH, Ko YH, Ahn YC, Park K: Extranodal nasal type NK/T-cell lymphoma: elucidating clinical prognostic factors for risk-based stratification of therapy. Eur J Cancer; 2005 Jul;41(10):1402-8
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  • [Title] Extranodal nasal type NK/T-cell lymphoma: elucidating clinical prognostic factors for risk-based stratification of therapy.
  • The purpose of this study was to define distinctive clinical features of "nasal" and "nasal-type" NK/T cell lymphomas by assessing prognostic factors.
  • The anatomic definition of extranasal NK/T cell lymphoma has been vague resulting in variable definitions of extranasal sites by different groups.
  • We analysed the clinical behavior of 90 NK/T cell lymphoma patients and attempted to elucidate the prognostic factors for risk-based stratification of therapy.
  • We observed no significant difference between "nasal" and "nasal-type" NK/T cell lymphomas in regards to clinical features and survival using the conventional anatomic classification.
  • We suggest the categorisation of the two subtypes of NK/T cell lymphoma as follows: UNKTL (upper aerodigestive tract NK/T cell lymphoma) including all lymphomas confined to nasal cavity, nasopharynx, and the upper aerodigestive tract and EUNKTL (extra-upper aerodigestive tract NK/T cell lymphoma) group to include all sites other than the UNKTL group.
  • The EUNKTL group in this study had advanced stage at diagnosis, higher LDH, higher IPI score, poorer performance and inferior response to the anthracycline-based chemotherapy with statistical significance.
  • [MeSH-major] Killer Cells, Natural / pathology. Lymphoma, T-Cell / pathology. Nose Neoplasms / pathology

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  • (PMID = 15963893.001).
  • [ISSN] 0959-8049
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
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36. Demers NM, Bowers J, Appin C, Morgan MB: Malignant histiocytosis of the skin: a case report and review of the literature. J Dermatol Case Rep; 2009 Apr 5;3(1):4-7
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  • [Title] Malignant histiocytosis of the skin: a case report and review of the literature.
  • BACKGROUND: Malignant histiocytosis is a rare neoplasm composed of abnormal histiocytes typically affecting the liver, spleen, lymph nodes, and bone marrow.
  • MAIN OBSERVATIONS: A 74-year-old white man presented to the dermatology clinic with complaints of a non-healing ulcerated lesion on his cheek of several months duration.
  • The prominent CD-68 and lysozyme staining along with the histological features, the clinical presentation of erythematous nodules with diffuse erythematous plaques, and absence of bone marrow findings, led to the diagnosis of malignant histiocytosis confined to the skin.
  • CONCLUSION: Malignant histiocytosis involving the skin is rare.
  • The presence of large pleomorphic epithelioid cells with foamy cytoplasm, with or without engulfed erythrocytes should alert the dermatopathologist to the possibility of malignant histiocytosis.
  • Appropriate immunohistochemical evaluation, including CD-43, CD-68, CD-1a, S-100, and lysozyme, should be completed to confirm the diagnosis.

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  • (PMID = 21886719.001).
  • [ISSN] 1898-7249
  • [Journal-full-title] Journal of dermatological case reports
  • [ISO-abbreviation] J Dermatol Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Poland
  • [Other-IDs] NLM/ PMC3157786
  • [Keywords] NOTNLM ; cutaneous histiocytosis / histiocytic sarcoma / skin / tumor / ulcer
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37. Chang CH, Hsu YH: Hyper-IgE syndrome with Epstein-Barr virus associated extranodal NK/T cell lymphoma of skin. Kaohsiung J Med Sci; 2010 Apr;26(4):206-10
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  • [Title] Hyper-IgE syndrome with Epstein-Barr virus associated extranodal NK/T cell lymphoma of skin.
  • Multiple erythematous papules and nodules with ulceration were found on her face and right forearm.
  • A skin biopsy showed angiocentric and angiodestructive atypical lymphoid infiltration.
  • Accordingly, this indicates that Epstein-Barr virus infection may have induced the extranodal natural killer/T cell lymphoma in this patient with hyper-IgE syndrome.
  • [MeSH-major] Herpesvirus 4, Human / physiology. Job Syndrome / complications. Job Syndrome / virology. Lymphoma, Extranodal NK-T-Cell / complications. Lymphoma, Extranodal NK-T-Cell / virology. Skin Neoplasms / complications. Skin Neoplasms / virology

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  • [Copyright] Copyright 2010 Elsevier. Published by Elsevier B.V. All rights reserved.
  • (PMID = 20434102.001).
  • [ISSN] 1607-551X
  • [Journal-full-title] The Kaohsiung journal of medical sciences
  • [ISO-abbreviation] Kaohsiung J. Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
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38. Seishima M, Yuge M, Kosugi H, Nagasaka T: Extranodal NK/T-cell lymphoma, nasal type, possibly arising from chronic Epstein-Barr virus infection. Acta Derm Venereol; 2010;90(1):102-3
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  • [Title] Extranodal NK/T-cell lymphoma, nasal type, possibly arising from chronic Epstein-Barr virus infection.
  • [MeSH-major] Epstein-Barr Virus Infections / complications. Lymphocytes / virology. Lymphoma, Extranodal NK-T-Cell / virology. Skin / virology
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biopsy. Chronic Disease. Diagnostic Errors. Fatal Outcome. Female. Humans. Immunophenotyping. Melkersson-Rosenthal Syndrome / diagnosis. Middle Aged. Treatment Failure

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  • (PMID = 20107744.001).
  • [ISSN] 1651-2057
  • [Journal-full-title] Acta dermato-venereologica
  • [ISO-abbreviation] Acta Derm. Venereol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Sweden
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39. Ferenczi K, Summers P, Aubert P, Cooper B, Meyerson H, Cooper KD, Honda K: A case of CD30+ nasal natural killer/T-cell lymphoma. Am J Dermatopathol; 2008 Dec;30(6):567-71
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  • [Title] A case of CD30+ nasal natural killer/T-cell lymphoma.
  • Extranodal nasal natural killer (NK)/T-cell lymphoma is a very rare lymphoma characterized by strong association with Epstein-Barr virus infection, very aggressive clinical behavior, and poor prognosis.
  • The typical phenotype of neoplastic natural killer cells in this entity is as follows: CD2+, CD56+, surface CD3-, cytoplasmic CD3epsilon+, and cytotoxic granule-associated protein positive.
  • CD30 expression, a phenotype characteristic of anaplastic large-cell lymphomas, is not a typical feature of nasal NK/T-cell lymphomas.
  • We describe the case of a 42-year-old woman with chronic nasal congestion and septal deviation who presented with progressive generalized tender erythematous plaques.
  • A skin biopsy revealed an atypical angiocentric mononuclear cell infiltrate.
  • Strong CD30 and CD3e immunoreactivities were noted in large atypical mononuclear cells within the infiltrate initially suggestive of a CD30+ T-cell lymphoma.
  • However, flow cytometry of the skin lesion indicated that the cells were CD2+, CD4-, CD8-, and lacked surface CD3 more typical of a neoplasm of natural killer cells.
  • Further studies revealed that the cells were CD56+, T-cell-restricted intracellular antigen-1+, and contained Epstein-Barr virus sequences consistent with a nasal-type NK/T-cell lymphoma.
  • High titers of Epstein-Barr virus in the blood, evidence of sinonasal disease, and absence of a T-cell receptor gene rearrangement were additional features consistent with the diagnosis.
  • The patient had a very aggressive clinical course and, despite combination chemotherapy, died 8 months after the onset of skin lesions.
  • This case represents an example of nasal-type NK/T-cell lymphoma with expression of CD30.
  • When presenting in the skin, the phenotypic and morphologic features of this lymphoma may lead to an erroneous diagnosis of a CD30+ large-T-cell lymphoma.
  • [MeSH-major] Antigens, CD30 / metabolism. Lymphoma, T-Cell, Cutaneous / diagnosis. Natural Killer T-Cells / immunology. Natural Killer T-Cells / pathology. Nose Neoplasms / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Immunophenotyping. Lymphoma, Large-Cell, Anaplastic / diagnosis. Lymphoma, Large-Cell, Anaplastic / immunology. Lymphoma, Large-Cell, Anaplastic / pathology

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  • (PMID = 19033930.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD30
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40. Kim SJ, Kim BS, Choi CW, Seo HY, Seol HR, Sung HJ, Kim IS, Kim CY, Jung KY, Kim JS: Treatment outcome of front-line systemic chemotherapy for localized extranodal NK/T cell lymphoma in nasal and upper aerodigestive tract. Leuk Lymphoma; 2006 Jul;47(7):1265-73
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  • [Title] Treatment outcome of front-line systemic chemotherapy for localized extranodal NK/T cell lymphoma in nasal and upper aerodigestive tract.
  • We analysed the treatment outcome of localized extranodal NK/T cell lymphoma initially treated with CEOP-B chemotherapy based on the primary site of involvement (nasal cavity vs. upper aerodigestive tract) and treatment modality (chemotherapy vs. chemotherapy followed by radiotherapy.
  • Forty-three patients newly diagnosed as extranodal NK/T cell lymphoma were analysed: 29 cases from nasal cavity/nasopharynx and 14 from upper aerodigestive tract.
  • There may be a tendency for better overall survival in group of upper aerodigestive tract lymphoma than the nasal cavity/nasopharynx group (P = 0.0643).
  • However, front-line CEOP-B chemotherapy has a limited role and adjuvant radiotherapy failed to improve survival in localized extranodal NK/T cell lymphoma.
  • [MeSH-major] Antineoplastic Agents / pharmacology. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Killer Cells, Natural / cytology. Lymphoma, T-Cell / drug therapy. Lymphoma, T-Cell / pathology

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  • (PMID = 16923556.001).
  • [ISSN] 1042-8194
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 11056-06-7 / Bleomycin; 3Z8479ZZ5X / Epirubicin; 5J49Q6B70F / Vincristine; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CEOP-B protocol
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41. Kako S, Izutsu K, Ota Y, Minatani Y, Sugaya M, Momose T, Ohtomo K, Kanda Y, Chiba S, Motokura T, Kurokawa M: FDG-PET in T-cell and NK-cell neoplasms. Ann Oncol; 2007 Oct;18(10):1685-90
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  • [Title] FDG-PET in T-cell and NK-cell neoplasms.
  • BACKGROUND: A growing number of studies demonstrate the utility of (18)fluoro-2-deoxyglucose positron emission tomography (FDG-PET) in the management of malignant lymphoma.
  • The results of FDG-PET, however, have not been studied extensively for T-cell and natural killer (NK)-cell neoplasms.
  • PATIENTS AND METHODS: We retrospectively evaluated pretreatment FDG-PET scans in 41 patients with T/NK-cell neoplasms diagnosed according to the World Health Organization (WHO) classification.
  • Histological subtypes frequently included were peripheral T-cell lymphoma, unspecified (PTCLu, n = 11), extranodal NK/T-cell lymphoma, nasal type (ENKL, n = 8), primary cutaneous anaplastic large cell lymphoma (C-ALCL, n = 5), and angioimmunoblastic T-cell lymphoma (AILT, n = 4).
  • RESULTS: FDG-PET detected a lymphoma lesion in at least one site in 36 out of 41 patients.
  • The positive rate was equally high in most histological subtypes except for cutaneous lymphomas: PTCLu 91%, ENKL 100%, C-ALCL 60%, AILT 100%.
  • CONCLUSION: T/NK-cell neoplasms incorporated in this study were generally FDG-avid except for cutaneous lesions and bone marrow involvement.

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  • (PMID = 17716987.001).
  • [ISSN] 1569-8041
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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42. Colovic N, Jurisic V, Colovic M: Malignant histiocytosis with central nervous system involvement and hepatic mucinous cystadenoma in a single patient with review of the literature. J BUON; 2007 Oct-Dec;12(4):539-42
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  • [Title] Malignant histiocytosis with central nervous system involvement and hepatic mucinous cystadenoma in a single patient with review of the literature.
  • Malignant histiocytosis is a rare neoplasm of the reticuloendothelial system characterized by neoplastic proliferation of tissue histiocytes.
  • We report a case of malignant histiocytosis in a 64-year-old female initially operated on for a mucinous cystadenoma of her liver.
  • Histology and immunohistochemistry of the lymph node and bone marrow specimens showed extensive infiltration with atypical cells, resembling malignant histiocytes (CD45, CD45RO, CD11c, CD68, lysozyme, antitrypsin and alpha1-antichymotrypsin positive; CD1, CD35, B-cell and T-cells markers negative).
  • Her condition improved, she became conscious, her headache diminished, she became mobile but skin and nodal lesions reappeared along with extensive marrow histiocytic infiltration.
  • She finally died 22 months after diagnosis.
  • [MeSH-major] Brain Neoplasms / diagnosis. Histiocytic Sarcoma / diagnosis. Neoplasms, Second Primary / diagnosis


43. Meneses-García A, Herrera J, Mohar A, García-Cuellar C, Súchil-Bernal L: [Metalloproteinase (MMP-1, 2 and 11), tissue inhibitor of metalloproteinase-1 (TIMP-1), and p53 expression in nasal-type angiocentric T/NK-cell lymphoma: an immunohistochemical study]. Gac Med Mex; 2005 Jul-Aug;141(4):291-6
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  • [Title] [Metalloproteinase (MMP-1, 2 and 11), tissue inhibitor of metalloproteinase-1 (TIMP-1), and p53 expression in nasal-type angiocentric T/NK-cell lymphoma: an immunohistochemical study].
  • [Transliterated title] Expresión inmunohistoquímica de metaloproteasas (MMP-1, 2 Y 11) e inhibidor de metaloproteasas de tejido-1 (TIMP-1), y expresión de p53 en linfomas angiocéntricos de células T/NK tipo nasal.
  • Twenty cases of extraganglionar Nasal-type T/NK-cell lymphomas were analyzed at the National Cancer Institute of Mexico.
  • We performed immunohistochemistry to determine CD3, CD56, p53 cellular type and expression of (MMPs-1, 2, 11) matrix metalloproteinases and one tissue inhibitor of TIMP-1 metalloproteinase.
  • Demographic variables included, age, sex, primaony location, clinical stage, treatment and follow-up.
  • RESULTS: All studied cases were positive to cytoplasmic CD3, CD56 (NK cells), 19 of them were positive to p53, five of them with nuclear overexpression of p53 in more than 50% of neoplastic cells.
  • DISCUSSION: This type of lymphoma is a common neoplasm in Asia, Latin America and Mexico.
  • It is worth noting it has has been linked to Epstein-Barr virus with T/NK-cell phenotype, which often displays cellular atypia, an angiocentric growth pattern and necrosis.
  • It is clinically expressed by progressive destruction of midline facial soft tissue and has a poor prognosis.
  • [MeSH-major] Lymphoma, T-Cell / metabolism. Metalloproteases / metabolism. Nasal Cavity. Nasopharyngeal Neoplasms / metabolism. Nose Neoplasms / metabolism. Tissue Inhibitor of Metalloproteinase-1 / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Data Interpretation, Statistical. Female. Genes, p53. Humans. Immunohistochemistry. Immunophenotyping. Killer Cells, Natural / pathology. Male. Matrix Metalloproteinases. Middle Aged. Palatal Neoplasms / enzymology. Palatal Neoplasms / genetics. Palatal Neoplasms / metabolism. Palatal Neoplasms / pathology. Prognosis. Tumor Suppressor Protein p53

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  • (PMID = 16164124.001).
  • [ISSN] 0016-3813
  • [Journal-full-title] Gaceta médica de México
  • [ISO-abbreviation] Gac Med Mex
  • [Language] spa
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Mexico
  • [Chemical-registry-number] 0 / Tissue Inhibitor of Metalloproteinase-1; 0 / Tumor Suppressor Protein p53; EC 3.4.- / Metalloproteases; EC 3.4.24.- / Matrix Metalloproteinases
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44. Lee J, Suh C, Huh J, Jun HJ, Kim K, Jung C, Park K, Park YH, Ko YH, Kim WS: Effect of positive bone marrow EBV in situ hybridization in staging and survival of localized extranodal natural killer/T-cell lymphoma, nasal-type. Clin Cancer Res; 2007 Jun 1;13(11):3250-4
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  • [Title] Effect of positive bone marrow EBV in situ hybridization in staging and survival of localized extranodal natural killer/T-cell lymphoma, nasal-type.
  • PURPOSE: The aim of the study was to determine the effect of EBV-encoded RNA-1 in situ hybridization (EBER-1 ISH) in bone marrow specimens on survival outcome in patients with clinical stage I/II natural killer/T-cell lymphoma.
  • EXPERIMENTAL DESIGN: We systematically did EBER-1 ISH on 182 archival bone marrow tissues from 91 patients who were diagnosed of stage I/II natural killer/T-cell lymphoma and analyzed the correlation between bone marrow EBER-1 ISH status and survival.
  • [MeSH-major] Bone Marrow / virology. Epstein-Barr Virus Infections / complications. Herpesvirus 4, Human / metabolism. Lymphoma, T-Cell / mortality. Lymphoma, T-Cell / virology. Nasopharyngeal Neoplasms / mortality. Nasopharyngeal Neoplasms / virology. Neoplasm Staging / methods
  • [MeSH-minor] Aged. Antigens, CD3 / biosynthesis. Bone Marrow Cells / metabolism. Female. Humans. In Situ Hybridization. Killer Cells, Natural / metabolism. Killer Cells, Natural / virology. Male. Middle Aged

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  • (PMID = 17545530.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD3
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45. Cortese L, Paciello O, Papparella S: Morphological characterisation of malignant histiocytosis in a cat. Folia Morphol (Warsz); 2008 Nov;67(4):299-303
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  • [Title] Morphological characterisation of malignant histiocytosis in a cat.
  • Malignant histiocytosis (MH) is a progressive systemic neoplastic proliferation of morphologically atypical histiocytes, well characterised in humans and dogs but only recently identified in the cat.
  • The purpose of this study was to describe the clinical, histological, immunohistochemical and ultrastructural findings of MH in a cat, together with the diagnostic work-up and a list of differential diagnoses.
  • Clinical evaluation included a complete blood-cell count, serum biochemistry, urinalysis, serology and ultrasound examination.
  • The cat had clinical signs of depression, thinness, dehydration, pale mucous membranes and tachycardia.
  • By immunohistochemistry, positivity for lysozyme and alpha1-antitrypsin and a scattered positivity for Mac 387 were observed.
  • MH in the cat needs to be differentiated from diffuse granulomatous disease, non-Hodgkin's lymphoma and Hodgkin's-like disease.
  • The morphological features of the tumour cells, combined with immunohistochemical and ultrastructural observation, are consistent with a diagnosis of MH in the cat.
  • [MeSH-major] Cat Diseases / pathology. Histiocytic Sarcoma / veterinary

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  • (PMID = 19085873.001).
  • [ISSN] 0015-5659
  • [Journal-full-title] Folia morphologica
  • [ISO-abbreviation] Folia Morphol. (Warsz)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
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46. Pamukçuoğlu M, Nasiroğlu N, Yildirim N, Ozçelik O, Oksüzoğlu B, Abali H, Zengin N: [Sinonasal NK/T-cell lymphoma mimicking Wegener's granulomatosis: a case report]. Tuberk Toraks; 2006;54(3):277-80
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  • [Title] [Sinonasal NK/T-cell lymphoma mimicking Wegener's granulomatosis: a case report].
  • [Transliterated title] Wegener granülomatozisi taklit eden sinonazal bölge tutulumlu NK/T-hücreli lenfoma: olgu sunumu.
  • In Western population, sinonasal malignant lymphoma is rare and constitutes 1.5% of all non-Hodgkin lymphoma (NHL) and 2.2% of extranodal lymphomas.
  • Herein, we present a typical WG with isolated sinonasal tract involvement with clinical, and radiological findings with the final diagnosis of NK/T-cell angiocentric lymphoma by the repeated biopsies.
  • Since both diseases have same clinical and radiological findings differential diagnosis may be difficult.
  • [MeSH-major] Granulomatosis with Polyangiitis / diagnosis. Lymphoma, T-Cell / diagnosis. Paranasal Sinus Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans

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  • (PMID = 17001547.001).
  • [ISSN] 0494-1373
  • [Journal-full-title] Tüberküloz ve toraks
  • [ISO-abbreviation] Tuberk Toraks
  • [Language] tur
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Turkey
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47. Li J, Li GN, Sun ZX, Liu XH, Li Q: [Malignant histiocytosis in a neonate]. Zhongguo Dang Dai Er Ke Za Zhi; 2009 Aug;11(8):648
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  • [Title] [Malignant histiocytosis in a neonate].
  • [MeSH-major] Histiocytic Sarcoma / diagnosis

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  • (PMID = 19695191.001).
  • [ISSN] 1008-8830
  • [Journal-full-title] Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
  • [ISO-abbreviation] Zhongguo Dang Dai Er Ke Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
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48. Huang JJ, Li HR, Huang Y, Jiang WQ, Xu RH, Huang HQ, Lv Y, Xia ZJ, Zhu XF, Lin TY, Li ZM: Beclin 1 expression: a predictor of prognosis in patients with extranodal natural killer T-cell lymphoma, nasal type. Autophagy; 2010 Aug;6(6):777-83
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  • [Title] Beclin 1 expression: a predictor of prognosis in patients with extranodal natural killer T-cell lymphoma, nasal type.
  • The function and expression of Beclin 1 in natural killer T-cell lymphoma is largely unexplored.
  • The study aimed to investigate Beclin 1 expression and its relationship with prognosis in extranodal natural killer T-cell lymphoma, nasal type (EN KL).
  • The clinical significance of Beclin 1 in EN KL was statistically analyzed.
  • The new clinico-pathological prognostic model may be help identify patients with different clinical outcomes.
  • [MeSH-major] Apoptosis Regulatory Proteins / metabolism. Lymphoma, Extranodal NK-T-Cell / diagnosis. Lymphoma, Extranodal NK-T-Cell / metabolism. Membrane Proteins / metabolism. Nose Neoplasms / diagnosis. Nose Neoplasms / metabolism

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  • (PMID = 20639699.001).
  • [ISSN] 1554-8635
  • [Journal-full-title] Autophagy
  • [ISO-abbreviation] Autophagy
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Apoptosis Regulatory Proteins; 0 / BECN1 protein, human; 0 / Membrane Proteins
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49. Ma X, Guo Y, Pang Z, Wang B, Lu H, Gu YJ, Guo X: A randomized phase II study of CEOP with or without semustine as induction chemotherapy in patients with stage IE/IIE extranodal NK/T-cell lymphoma, nasal type in the upper aerodigestive tract. Radiother Oncol; 2009 Dec;93(3):492-7
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  • [Title] A randomized phase II study of CEOP with or without semustine as induction chemotherapy in patients with stage IE/IIE extranodal NK/T-cell lymphoma, nasal type in the upper aerodigestive tract.
  • PURPOSE: In this randomized phase II study, we evaluated the efficacy of semustine added to CEOP regimen as induction chemotherapy in patients with stage I(E)/II(E) extranodal NK/T-cell lymphoma, nasal type in the upper aerodigestive tract.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Lymphoma, Extranodal NK-T-Cell / drug therapy. Nose Neoplasms / drug therapy. Semustine / administration & dosage

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  • (PMID = 19782419.001).
  • [ISSN] 1879-0887
  • [Journal-full-title] Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
  • [ISO-abbreviation] Radiother Oncol
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial
  • [Publication-country] Ireland
  • [Chemical-registry-number] 13909-09-6 / Semustine; 3Z8479ZZ5X / Epirubicin; 5J49Q6B70F / Vincristine; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CEOP protocol 1
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50. Reyes VE Jr, Al-Saleem T, Robu VG, Smith MR: Extranodal NK/T-cell lymphoma nasal type: efficacy of pegaspargase. Report of two patients from the United Sates and review of literature. Leuk Res; 2010 Jan;34(1):e50-4
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  • [Title] Extranodal NK/T-cell lymphoma nasal type: efficacy of pegaspargase. Report of two patients from the United Sates and review of literature.

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  • (PMID = 19786301.001).
  • [ISSN] 1873-5835
  • [Journal-full-title] Leukemia research
  • [ISO-abbreviation] Leuk. Res.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA006927-44; United States / NCI NIH HHS / CA / P30 CA006927; United States / NCI NIH HHS / CA / CA06927; United States / NCI NIH HHS / CA / P30 CA006927-44
  • [Publication-type] Case Reports; Letter; Research Support, N.I.H., Extramural; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / pegaspargase; 30IQX730WE / Polyethylene Glycols; EC 3.5.1.1 / Asparaginase
  • [Number-of-references] 33
  • [Other-IDs] NLM/ NIHMS144531; NLM/ PMC2813903
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51. Kerl K, Prins C, Cerroni L, French LE: Regression of extranodal natural killer/T-cell lymphoma, nasal type with denileukin diftitox (Ontak) and bexarotene (Targretin): report of a case. Br J Dermatol; 2006 May;154(5):988-91
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  • [Title] Regression of extranodal natural killer/T-cell lymphoma, nasal type with denileukin diftitox (Ontak) and bexarotene (Targretin): report of a case.
  • We report a patient with rapidly progressive Epstein-Barr virus-positive nasal type extranodal natural killer/T-cell lymphoma (extranodal NKTCL), treated with a combination of denileukin diftitox (Ontak) and oral bexarotene (Targretin).
  • To our knowledge this is the first case of extranodal NKTCL treated with denileukin diftitox and bexarotene.
  • Combination treatment with denileukin diftitox and bexarotene should be further assessed in this aggressive type of cutaneous lymphoma.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Lymphoma, T-Cell, Cutaneous / drug therapy. Skin Neoplasms / drug therapy
  • [MeSH-minor] Diphtheria Toxin / administration & dosage. Fatal Outcome. Humans. Interleukin-2 / administration & dosage. Killer Cells, Natural / pathology. Male. Middle Aged. Recombinant Fusion Proteins / administration & dosage. Tetrahydronaphthalenes / administration & dosage

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  • (PMID = 16634908.001).
  • [ISSN] 0007-0963
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Diphtheria Toxin; 0 / Interleukin-2; 0 / Recombinant Fusion Proteins; 0 / Tetrahydronaphthalenes; 25E79B5CTM / denileukin diftitox; A61RXM4375 / bexarotene
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52. Na II, Kang HJ, Park YH, Lee SS, Yoo HJ, Choe DH, Ryoo BY, Yang SH: Prognostic factors for classifying extranodal NK/T cell lymphoma, nasal type, as lymphoid neoplasia. Eur J Haematol; 2007 Jul;79(1):1-7
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  • [Title] Prognostic factors for classifying extranodal NK/T cell lymphoma, nasal type, as lymphoid neoplasia.
  • This study evaluated the applicability of prognostic factors commonly used for diagnosis of classical lymphoma outcomes to extranodal NK/T cell lymphoma, nasal type (NTCL).
  • Clinical features and their associations with lactate dehydrogenase (LDH) were evaluated in 70 patients.
  • [MeSH-major] Killer Cells, Natural / immunology. Lymphoma, T-Cell / classification. Nose Neoplasms / classification

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  • (PMID = 17598834.001).
  • [ISSN] 0902-4441
  • [Journal-full-title] European journal of haematology
  • [ISO-abbreviation] Eur. J. Haematol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] EC 1.1.1.27 / L-Lactate Dehydrogenase
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53. Sitthinamsuwan P, Pongpruttipan T, Chularojmontri L, Pattanaprichakul P, Khuhapinant A, Sukpanichnant S: Extranodal NK/T cell lymphoma, nasal type, presenting with primary cutaneous lesion mimicking granulomatous panniculitis: a case report and review of literature. J Med Assoc Thai; 2010 Aug;93(8):1001-7
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  • [Title] Extranodal NK/T cell lymphoma, nasal type, presenting with primary cutaneous lesion mimicking granulomatous panniculitis: a case report and review of literature.
  • BACKGROUND: Cutaneous extranodal NK/T-cell lymphoma, nasal type (NK/T) is relatively rare, associated with aggressive behavior and poor prognosis.
  • Histopathological findings, immunohistochemical study and EBV-encoded RNA (EBER) in situ hybridization are essential for the diagnosis.
  • CASE REPORT: A 54-year-old Thai man with NK/T of the nasal cavity initially presented with cutaneous NK/T mimicking granulomatous panniculitis.
  • CONCLUSION: Cutaneous NK/T can produce granulomatous panniculitis.
  • The recognition of atypical lymphoid cells showing angiocentricity together with immunohistochemistry and EBER in situ hybridization are crucial for the correct diagnosis.
  • [MeSH-major] Lymphoma, Extranodal NK-T-Cell / pathology. Nasal Cavity / pathology. Nose Neoplasms / pathology. Panniculitis / pathology
  • [MeSH-minor] Biopsy. Diagnosis, Differential. Fatal Outcome. Humans. Immunohistochemistry. Lymphoma, T-Cell, Cutaneous / pathology. Male. Middle Aged. Skin Neoplasms / pathology

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  • (PMID = 20718178.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Thailand
  • [Number-of-references] 25
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54. Takeuchi K, Yokoyama M, Ishizawa S, Terui Y, Nomura K, Marutsuka K, Nunomura M, Fukushima N, Yagyuu T, Nakamine H, Akiyama F, Hoshi K, Matsue K, Hatake K, Oshimi K: Lymphomatoid gastropathy: a distinct clinicopathologic entity of self-limited pseudomalignant NK-cell proliferation. Blood; 2010 Dec 16;116(25):5631-7
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  • [Title] Lymphomatoid gastropathy: a distinct clinicopathologic entity of self-limited pseudomalignant NK-cell proliferation.
  • Diagnostic errors in distinguishing between malignant and reactive processes can cause serious clinical consequences.
  • We report 10 cases of unrecognized self-limited natural killer-cell proliferation in the stomach, designated as lymphomatoid gastropathy (LyGa).
  • The cells were CD2(+/-), sCD3(-), cCD3(+), CD4(-), CD5(-), CD7(+), CD8(-), CD16(-), CD20(-), CD45(+), CD56(+), CD117(-), CD158a(-), CD161(-), T cell-restricted intracellular antigen-1(+), granzyme B(+), perforin(+), Epstein-Barr early RNA(-), T-cell receptor αβ(-), and T-cell receptor γδ(-).
  • Analysis of the 16 specimens biopsied from 10 patients led to a diagnosis of lymphoma or suspected lymphoma in 11 specimens, gastritis for 1 specimen, adenocarcinoma for 1 specimen, and LyGa or suspected LyGa for 3 specimens.
  • According to conventional histopathologic criteria, LyGa is probably diagnosed as lymphoma, especially as extranodal natural killer/T-cell lymphoma, nasal type.
  • However, LyGa is recognized as a pseudomalignant process because of its clinical characteristics.
  • [MeSH-major] Killer Cells, Natural / pathology. Lymphoma, T-Cell / pathology. Stomach Diseases / pathology
  • [MeSH-minor] Aged. Blotting, Western. Epstein-Barr Virus Infections / diagnosis. Epstein-Barr Virus Infections / genetics. Epstein-Barr Virus Infections / metabolism. Female. Flow Cytometry. Gene Rearrangement. Herpesvirus 4, Human / genetics. Humans. Immunoenzyme Techniques. Immunophenotyping. In Situ Hybridization. Male. Middle Aged. RNA, Messenger / genetics. Receptors, Antigen, T-Cell, alpha-beta / genetics. Receptors, Antigen, T-Cell, alpha-beta / metabolism. Receptors, Antigen, T-Cell, gamma-delta / genetics. Receptors, Antigen, T-Cell, gamma-delta / metabolism. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 20829373.001).
  • [ISSN] 1528-0020
  • [Journal-full-title] Blood
  • [ISO-abbreviation] Blood
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Messenger; 0 / Receptors, Antigen, T-Cell, alpha-beta; 0 / Receptors, Antigen, T-Cell, gamma-delta
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55. Wang H, Li XJ, Zhang SW, Xi Y: [Clinical study of extranodal NK-T cell lymphoma-nasal type]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2005 Nov;40(11):850-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinical study of extranodal NK-T cell lymphoma-nasal type].
  • OBJECTIVE: To discuss how the diagnosis, misdiagnosis and different treatment modalities affect the prognosis of the patients with extranodal NK-T cell lymphoma-nasal type.
  • METHODS: A retrospective study was made on the clinical characteristics, treatment modality, short-term effect, and survival rate of 68 patients with extranodal NK-T cell lymphoma-nasal type.
  • 4% (17/18) for limited disease in I(E) group compared 61.9% (26/42) for out-cavity disease in I(E) group, of which the difference is significant (P =0. 012).
  • The 1-years, 3-years and 5-years survival rate of the I(E) intra-cavity group were 100%, 77.8%, 59.8%, and those of ex-cavity group were 80.1%, 48.5% and 14.6%, respectively.
  • CONCLUSIONS: The early clinical manifestation of extranodal NK-T cell lymphoma-nasal type is not typical,which is easy to be misdiagnosed and mistreated.
  • Diseased stage I(E) out-cavity and above should be treated with combined therapy.
  • [MeSH-major] Lymphoma, Extranodal NK-T-Cell. Nose Neoplasms

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  • (PMID = 16408753.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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56. Nong L, Zhang S, Li Y, Zhang Y, Wang Y, Li T: [Study on expression of natural killer (NK) cell C-type lectin-like receptors in nasal NK/T-cell lymphomas]. Zhonghua Bing Li Xue Za Zhi; 2010 May;39(5):319-24
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  • [Title] [Study on expression of natural killer (NK) cell C-type lectin-like receptors in nasal NK/T-cell lymphomas].
  • OBJECTIVE: To investigate the expression and possible role of C-type lectin-like natural killer cell receptors, including CD94 and NKG2s, in extranodal NK/T-cell lymphoma, nasal type (EN-NK/T-NT).
  • METHODS: Reverse transcriptase polymerase chain reaction (RT-PCR) was used to detect the expression of CD94 and NKG2s in tissue sections of 21 cases of EN-NK/T-NT(confirmed by histology, immunohistochemistry, in-situ hybridization for Epstein-Barr virus(EBV) and PCR for T-cell receptor genes), eight midline B cell lymphomas (BCL), 10 peripheral T cell lymphoma of lymph nodes (PTCL), five spleens, five thymuses and five chronic nasopharyngitis.
  • RESULTS: All 21 cases of EN-NK/T-NT showed typical histological features, with expression of CD3epsilon, CD56, cytotoxic granules and positivity of EBV in 20 cases.
  • The RT-PCR results showed a high level expression of CD94 (85.7%) and NKG2 members (95.2% totally, with NKG2A/2B in 85.7%, NKG2D in 61.9%, NKG2F in 14.3%, NKG2C/2E in 4.8%, respectively and sequentially) in EN-NK/T-NT.
  • The differences of CD94 and NKG2 expression between EN-NK/T-NT and BCL or TCL were statistically significant (P<0.01).
  • Co-expression of CD94 and NKG2 was found in 17 out of 21 EN-NK/T-NT cases (81.0%).
  • CONCLUSIONS: The specific and sequential expression nature of CD94 and NKG2 in EN-NK/T-NT, mimics the developmental expression model in their normal counterparts, and suggests that the tumor cells of most cases are being activated and keeping in a stage as the functional NK cells.
  • Detection of these molecules may provide a useful tool to confirm the diagnosis of NK cell lymphoma.
  • [MeSH-major] Lymphoma, Extranodal NK-T-Cell. NK Cell Lectin-Like Receptor Subfamily C / metabolism. NK Cell Lectin-Like Receptor Subfamily D / metabolism. Nose Neoplasms
  • [MeSH-minor] Adolescent. Adult. Aged. Diagnosis, Differential. Epstein-Barr Virus Infections / virology. Female. Follow-Up Studies. Herpesvirus 4, Human / isolation & purification. Humans. Lymphoma, B-Cell / metabolism. Lymphoma, B-Cell / pathology. Lymphoma, T-Cell, Peripheral / metabolism. Lymphoma, T-Cell, Peripheral / pathology. Male. Middle Aged. Survival Rate. Young Adult

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  • (PMID = 20654155.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / NK Cell Lectin-Like Receptor Subfamily C; 0 / NK Cell Lectin-Like Receptor Subfamily D
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57. Kost Al M, Kost Alová M, Belada D, Laco J: Cutaneous natural killer (NK) / T-cell lymphoma: nasal type with extensive facial destruction. Int J Dermatol; 2009 Dec;48(12):1338-42
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  • [Title] Cutaneous natural killer (NK) / T-cell lymphoma: nasal type with extensive facial destruction.
  • [MeSH-major] Lymphoma, T-Cell, Cutaneous / pathology. Nose Neoplasms / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cyclophosphamide / therapeutic use. Disease Progression. Doxorubicin / therapeutic use. Epstein-Barr Virus Infections / complications. Fatal Outcome. Female. Humans. Immunohistochemistry. Lymphohistiocytosis, Hemophagocytic / complications. Middle Aged. Natural Killer T-Cells / immunology. Prednisone / therapeutic use. Vincristine / therapeutic use

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  • [CommentIn] Int J Dermatol. 2013 Oct;52(10):1276-7 [24073909.001]
  • (PMID = 19930492.001).
  • [ISSN] 1365-4632
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CHOP protocol
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58. Assanasen T, Wannakrairot P, Keelawat S, Ruangvejvorachai P, Pramprayoon N: Extranodal malignant lymphoma of the upper aerodigestive tract: prevalence of Epstien-Barr virus (EBV) infection in King Chulalongkorn Memorial Hospital. J Med Assoc Thai; 2005 Sep;88 Suppl 4:S266-73
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  • [Title] Extranodal malignant lymphoma of the upper aerodigestive tract: prevalence of Epstien-Barr virus (EBV) infection in King Chulalongkorn Memorial Hospital.
  • Malignant lymphomas arising in this site may be associated with EBV.
  • OBJECTIVES: To determine the prevalence of EBV infection in extranodal malignant lymphomas of the upper aerodigestive tract.
  • MATERIAL AND METHOD: The expression of EBV mRNAs (EBERs) of malignant lymphoma was studied by means of in situ hybridization in formalin-fixed, paraffin-embedded specimens.
  • Ten of 42 cases (23.81%) expressed EBER transcripts and were extranodal NK/T-cell lymphomas, nasal type (7 cases), plasmablastic lymphomas (2 cases) and diffuse large B-cell lymphoma (1 case).
  • Three of 4 cases (75%) of known HIV-seropositive cases were EBV-positive (2 plasmablastic lymphomas and 1 diffuse large B-cell lymphoma).
  • CONCLUSION: In the upper aerodigestive tract, EBV was present in some but not all malignant lymphoma.
  • It was associated with extranodal NK/T-cell lymphoma, nasal type and B-cell lymphoma arising in HIV-infected patients, but it was not found in B-cell lymphoma arising in immunocompetent patients.
  • [MeSH-major] Epstein-Barr Virus Infections / epidemiology. Herpesvirus 4, Human / isolation & purification. Lymphoma / virology. Lymphoma, B-Cell / virology. Lymphoma, T-Cell / virology. Respiratory System / virology. Upper Gastrointestinal Tract / virology

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  • (PMID = 16623040.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Thailand
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59. Kim SJ, Oh SY, Hong JY, Chang MH, Lee DH, Huh J, Ko YH, Ahn YC, Kim HJ, Suh C, Kim K, Kim WS: When do we need central nervous system prophylaxis in patients with extranodal NK/T-cell lymphoma, nasal type? Ann Oncol; 2010 May;21(5):1058-63
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  • [Title] When do we need central nervous system prophylaxis in patients with extranodal NK/T-cell lymphoma, nasal type?
  • BACKGROUND: The incidence and risk factors of central nervous system (CNS) invasion is still unclear in extranodal natural killer (NK)/T-cell lymphoma, nasal type.
  • PATIENTS AND METHODS: We analyzed 208 patients to study the clinical features and outcomes of CNS disease in extranodal NK/T-cell lymphoma.
  • The clinical variables associated with CNS disease were Ann Arbor stage III/IV (15.87%, P <0.001), regional lymph node involvement (10.41%, P = 0.006), group III/IV of NK/T-cell lymphoma prognostic index (NKPI; 10.20%, P = 0.003), high/high-intermediate international prognostic index (9.30%, P = 0.072) and extra-upper aerodigestive primary sites (9.75%, P = 0.008).
  • In multivariate analysis, NKPI retained the strongest statistical power to predict CNS disease (P = 0.007, relative risk 9.289, 95% confidence interval 1.828-47.212) in extranodal NK/T-cell lymphoma.
  • CONCLUSIONS: Despite extranodal NK/T-cell lymphoma frequently involves paranasal sinus, a routine CNS evaluation and prophylaxis do not seem to be necessary in NKPI group I or II patients due to a very low incidence.

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  • (PMID = 19850636.001).
  • [ISSN] 1569-8041
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] England
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60. Massone C, Lozzi GP, Egberts F, Fink-Puches R, Cota C, Kerl H, Cerroni L: The protean spectrum of non-Hodgkin lymphomas with prominent involvement of subcutaneous fat. J Cutan Pathol; 2006 Jun;33(6):418-25
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  • [Title] The protean spectrum of non-Hodgkin lymphomas with prominent involvement of subcutaneous fat.
  • BACKGROUND: Subcutaneous T-cell lymphoma (STCL) represents a controversial entity and a confused concept in the field of cutaneous T-cell lymphomas (CTCLs).
  • Recently, alpha/beta+/CD8+ STCL has been recognized by the new World Health Organization (WHO)-European Organization for Research and Treatment of Cancer (EORTC) classification of primary cutaneous lymphomas as a distinct entity in the group of CTCLs.
  • OBSERVATIONS: We reviewed a series of 53 biopsies from 26 patients (F : M = 19:7; median age: 48; range 18-87) of cutaneous B- and T-cell lymphomas characterized by prominent involvement of the subcutaneous tissue.
  • (ii) extranodal NK/T-cell lymphoma, nasal type: n = 2;.
  • (iii) cutaneous gamma/delta T-cell lymphoma: n = 2;.
  • (iv) anaplastic CD30+ large T-cell lymphoma: n = 1;.
  • (v) diffuse large B-cell lymphoma, secondary cutaneous: n = 3;.
  • (vi) lymphoplasmacytic lymphoma, secondary cutaneous: n = 1;.
  • CONCLUSIONS: We demonstrated the protean nature of lymphomas with prominent involvement of the subcutaneous fat tissues.
  • The term STCL should be restricted to a homogeneous group of cases characterized morphologically by an exclusive involvement of subcutaneous tissues, immunohistochemically by a T-cytotoxic alpha/beta phenotype, and biologically by a relatively good prognosis.
  • [MeSH-major] Adipose Tissue / pathology. Lymphoma, T-Cell, Cutaneous / pathology. Skin Neoplasms / pathology. Subcutaneous Tissue / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Biopsy. Female. Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor. Humans. Immunoenzyme Techniques. Immunophenotyping. Male. Middle Aged. Polymerase Chain Reaction / methods

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  • (PMID = 16776717.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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61. Jain S, Kanarek N, Arceci RJ: Analysis of histiocytosis deaths in the US and recommendations for incidence tracking. J Registry Manag; 2010;37(4):156-62
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  • [Title] Analysis of histiocytosis deaths in the US and recommendations for incidence tracking.
  • OBJECTIVE: We determined the frequency of deaths associated with histiocytosis in the United States (US) for which incidence data are lacking and could be potentially important in understanding outcomes for patients with these disorders.
  • METHODS: National death data collected by the US Vital Statistics Reporting System and aggregated using wonder.cdc.gov were analyzed for underlying cause of death due to malignant histiocytosis (MH), Langerhans cell histiocytosis (LCH) and Letterer-Siwe disease (LS, a form of LCH) for 3 periods: 1979-1988, 1989-1998, and 1999-2006.
  • To capture histiocytosis, International Classification of Diseases (ICD)-9 codes 202.3, 202.5, and 277.8 and ICD-10 codes C96.1, C96.0, and D76.0-76.1 were used.
  • Other listed contributing causes of death with a histiocytosis diagnosis were also examined.
  • RESULTS: A total of 2,416 deaths primarily due to histiocytosis as underlying cause occurred between 1979 and 2006.
  • On comparison of the underlying and contributory cause for the period 1999-2006, histiocytosis mentioned on the death certificate as a contributory cause (N=562) occurs nearly as often as does underlying cause alone (N=648).
  • Death rates of each type of histiocytosis dropped significantly from 1979 to 1988 to 1999-2006 (p-value <0.0001).
  • CONCLUSIONS/DISCUSSION: Death due to histiocytosis or histiocytosis-related causes is a rare event that is trackable in the US by person, place and time characteristics.
  • [MeSH-major] Histiocytosis / mortality. Registries

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  • (PMID = 21688746.001).
  • [ISSN] 1945-6123
  • [Journal-full-title] Journal of registry management
  • [ISO-abbreviation] J Registry Manag
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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62. Zheng YY, Chen G, Zhou XG, Zhang SH, Zhang YN: [Morphologic and immunophenotypic analysis of angioimmunoblastic T-cell lymphoma]. Zhonghua Bing Li Xue Za Zhi; 2009 Mar;38(3):173-7
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  • [Title] [Morphologic and immunophenotypic analysis of angioimmunoblastic T-cell lymphoma].
  • OBJECTIVE: To study the morphologic and immunophenotypic features of angioimmunoblastic T-cell lymphoma (AITL), as well as the origin of the proliferative follicular dendritic cells (FDCs) in AITL.
  • Cases of peripheral T-cell lymphoma, unspecified, extranodal NK/T-cell lymphoma, nasal-type, enteropathy-type T-cell lymphoma, anaplastic large cell lymphoma, subcutaneous panniculitis-like T-cell lymphoma and reactive lymphoid proliferation were selected as controls.
  • RESULTS: Amongst the 29 cases of AITL studied, 75.9% (22/29) showed aberrant expression of CD10, while all except one of the controlled cases were negative, 82.8% (24/29) of the AITL cases expressed CXCL13, while all cases of peripheral T-cell lymphoma, unspecified were negative.
  • As for bcl-6 staining, although the highest percentage of bcl-6-positive cells was observed in AITL, the expression pattern was not useful in differentiating AITL from peripheral T-cell lymphoma, unspecified and lymphoid reaction.
  • Two of the cases, which contained obvious germinal centers, had the follicular dendritic cell meshwork extending beyond the lymphoid follicles.
  • [MeSH-major] Chemokine CXCL13 / metabolism. Dendritic Cells, Follicular / pathology. Immunoblastic Lymphadenopathy / pathology. Lymphoma, T-Cell, Peripheral / pathology. Neprilysin / metabolism

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  • (PMID = 19575853.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / CXCL13 protein, human; 0 / Chemokine CXCL13; 0 / Proto-Oncogene Proteins c-bcl-6; 0 / Receptors, Complement 3d; EC 3.4.24.11 / Neprilysin
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63. Yu JB, Zuo Z, Tang Y, Zhao S, Zhang YC, Bi CF, Wang WY, Zhang WY, Wang L, Liu WP: Extranodal nasal-type natural killer/T-cell lymphoma of the skin: a clinicopathologic study of 16 cases in China. Hum Pathol; 2009 Jun;40(6):807-16
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  • [Title] Extranodal nasal-type natural killer/T-cell lymphoma of the skin: a clinicopathologic study of 16 cases in China.
  • Extranodal nasal-type natural killer/T-cell lymphoma presenting in skin, either primary or secondary, is relatively rare in China, accounting for about 4.1% of tumors.
  • Sixteen Chinese cases of cutaneous natural killer/T-cell lymphomas were investigated retrospectively by pathology, immunophenotype, genotype, Epstein-Barr virus status, and survival analysis.
  • In conclusion, both primary and secondary cutaneous natural killer/T-cell lymphomas are highly aggressive.
  • [MeSH-major] Lymphoma, T-Cell / pathology. Nose / pathology. Nose Neoplasms / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. China / epidemiology. Female. Humans. Killer Cells, Natural / pathology. Male. Middle Aged. Retrospective Studies

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  • (PMID = 19200574.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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64. Liang R: Advances in the management and monitoring of extranodal NK/T-cell lymphoma, nasal type. Br J Haematol; 2009 Oct;147(1):13-21
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  • [Title] Advances in the management and monitoring of extranodal NK/T-cell lymphoma, nasal type.
  • Extranodal natural killer (NK)/T-cell lymphoma, nasal type, has a unique geographic distribution.
  • A typical NK-cell phenotype is usually present: CD2(+), CD3 epsilon+, CD56(+), cytotoxic molecules+ and Epstein-Barr virus (EBV)+.
  • For localized nasal disease, radiotherapy is important, although chemotherapy is often added.
  • For extra-nasal or disseminated disease, systemic chemotherapy becomes the mainstay and the prognosis is usually poor.
  • Doxorubicin-containing regimens are not entirely satisfactory and L-asparaginase containing regimens are being investigated.
  • Patients with poor prognostic features may be considered for an early autologous haematopoietic stem cell transplant.
  • [MeSH-major] Lymphoma, Extranodal NK-T-Cell / therapy. Nose Neoplasms / therapy
  • [MeSH-minor] Combined Modality Therapy. Hematopoietic Stem Cell Transplantation. Humans. Neoplasm Staging

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  • (PMID = 19604234.001).
  • [ISSN] 1365-2141
  • [Journal-full-title] British journal of haematology
  • [ISO-abbreviation] Br. J. Haematol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Number-of-references] 83
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65. Yamaguchi M, Suzuki R, Kwong YL, Kim WS, Hasegawa Y, Izutsu K, Suzumiya J, Okamura T, Nakamura S, Kawa K, Oshimi K: Phase I study of dexamethasone, methotrexate, ifosfamide, L-asparaginase, and etoposide (SMILE) chemotherapy for advanced-stage, relapsed or refractory extranodal natural killer (NK)/T-cell lymphoma and leukemia. Cancer Sci; 2008 May;99(5):1016-20
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  • [Title] Phase I study of dexamethasone, methotrexate, ifosfamide, L-asparaginase, and etoposide (SMILE) chemotherapy for advanced-stage, relapsed or refractory extranodal natural killer (NK)/T-cell lymphoma and leukemia.
  • Extranodal natural killer (NK)/T-cell lymphoma, nasal type, and aggressive NK-cell leukemia are rare, and their standard therapy has not been established.
  • To develop an efficacious chemotherapeutic regimen, we conducted a dose-escalation feasibility study of a new chemotherapeutic regimen, SMILE, comprising the steroid dexamethasone, methotrexate, ifosfamide, L-asparaginase, and etoposide.
  • At level 1, six patients with extranodal NK/T-cell lymphoma, nasal type, were enrolled.
  • Although its safety and efficacy require further evaluation, we recommend a SMILE chemotherapy dose level of 1 for further clinical studies.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Leukemia, Lymphoid / drug therapy. Lymphoma, Extranodal NK-T-Cell / drug therapy

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  • Hazardous Substances Data Bank. ETOPOSIDE .
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  • (PMID = 18294294.001).
  • [ISSN] 1349-7006
  • [Journal-full-title] Cancer science
  • [ISO-abbreviation] Cancer Sci.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase I; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 6PLQ3CP4P3 / Etoposide; 7S5I7G3JQL / Dexamethasone; EC 3.5.1.1 / Asparaginase; UM20QQM95Y / Ifosfamide; YL5FZ2Y5U1 / Methotrexate
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66. Nakashima Y, Tagawa H, Suzuki R, Karnan S, Karube K, Ohshima K, Muta K, Nawata H, Morishima Y, Nakamura S, Seto M: Genome-wide array-based comparative genomic hybridization of natural killer cell lymphoma/leukemia: different genomic alteration patterns of aggressive NK-cell leukemia and extranodal Nk/T-cell lymphoma, nasal type. Genes Chromosomes Cancer; 2005 Nov;44(3):247-55
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  • [Title] Genome-wide array-based comparative genomic hybridization of natural killer cell lymphoma/leukemia: different genomic alteration patterns of aggressive NK-cell leukemia and extranodal Nk/T-cell lymphoma, nasal type.
  • Natural killer (NK) cell lymphomas/leukemias are highly aggressive lymphoid malignancies, but little is known about their genomic alterations, and thus there is an urgent need for identification and analysis of NK cell lymphomas/leukemias.
  • We performed an array CGH analysis for 27 NK-cell lymphoma/leukemia cases that were classified into two disease groups based on the World Health Organization Classification (10 aggressive NK-cell leukemia cases and 17 extranodal NK/T-cell [NK/T] lymphomas, nasal type).
  • The recurrent regions characteristic of the aggressive NK-cell leukemia group compared with those of the extranodal NK/T lymphoma, nasal-type group, were gain of 1q and loss of 7p15.1-p22.3 and 17p13.1.
  • Recurrent regions characteristic of the extranodal NK/T lymphoma, nasal-type group, compared with those of the other group were gain of 2q, and loss of 6q16.1-q27, 11q22.3-q23.3, 5p14.1-p14.3, 5q34-q35.3, 1p36.23-p36.33, 2p16.1-p16.3, 4q12, and 4q31.3-q32.1.
  • Our results can be expected to provide further insights into the genetic basis of lymphomagenesis and the clinicopathologic features of NK-cell lymphomas/leukemias.
  • [MeSH-major] Chromosome Aberrations. Chromosomes, Human / genetics. Genome, Human. Killer Cells, Natural / pathology. Leukemia, T-Cell / genetics. Lymphoma, T-Cell / genetics. Nose Neoplasms / genetics


67. Murakami YI, Yatabe Y, Sakaguchi T, Sasaki E, Yamashita Y, Morito N, Yoh K, Fujioka Y, Matsuno F, Hata H, Mitsuya H, Imagawa S, Suzuki A, Esumi H, Sakai M, Takahashi S, Mori N: c-Maf expression in angioimmunoblastic T-cell lymphoma. Am J Surg Pathol; 2007 Nov;31(11):1695-702
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  • [Title] c-Maf expression in angioimmunoblastic T-cell lymphoma.
  • The oncogene c-Maf was recently found to be overexpressed in approximately 50% of multiple myeloma cases, and a role for c-Maf in promoting cyclin D2 expression has been postulated.
  • We previously examined c-Maf expression in various T-cell lymphomas by reverse-transcription polymerase chain reaction and found extremely elevated c-Maf levels in angioimmunoblastic T-cell lymphoma (AILT).
  • In this study, we examined T-cell lymphomas for c-Maf and cyclin expression immunohistochemically.
  • Of 93 cases of T-cell lymphomas we investigated in the current study, c-Maf expression was seen in 23 out of 31 cases of AILT, 3 out of 11 of adult T-cell leukemia/lymphoma, 4 out of 19 of peripheral T-cell lymphoma, unspecified [PTCL(U)], and 0 out of 11 cases of mycosis fungoides, 0 out of 11 of anaplastic large cell lymphoma, and 1 out of 10 of extranodal NK/T-cell lymphoma, nasal type.
  • Double immunostaining in AILT revealed that the majority of c-Maf-positive cells were also positive for CD43 (MT1), CD45RO (UCHL-1), and CD4 but were negative for CD20 (L26).
  • Additionally, cyclins D1 and D2, which stimulate cell cycle progression, were overexpressed in a large number of the c-Maf-positive AILT samples.
  • Quantitative reverse-transcription polymerase chain reaction analysis also showed that c-Maf was overexpressed in 8/31 cases of AILT, 0/19 cases of PTCL(U), 0/11 cases of anaplastic large cell lymphoma, 0/10 cases of extranodal NK/T-cell lymphoma, nasal type, and 2/8 cases of multiple myeloma, presenting significant difference between AILT and PTCL(U) (P=0.016, chi test).
  • [MeSH-major] Biomarkers, Tumor / analysis. Immunoblastic Lymphadenopathy / metabolism. Lymphoma, T-Cell / chemistry. Proto-Oncogene Proteins c-maf / analysis

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  • (PMID = 18059226.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD20; 0 / Antigens, CD4; 0 / Antigens, CD43; 0 / Biomarkers, Tumor; 0 / CCND2 protein, human; 0 / Cyclin D; 0 / Cyclin D2; 0 / Cyclins; 0 / MAF protein, human; 0 / Proto-Oncogene Proteins c-maf; 0 / RNA, Messenger; 0 / UN1 sialoglycoprotein, human; EC 3.1.3.48 / Antigens, CD45
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68. Ishida F, Nishina S, Asano N, Sasaki S, Sekiguchi N, Nakazawa H, Ito T, Shikama N: Late relapse of extranodal natural killer/T cell lymphoma, nasal type, after more than ten years. Leuk Lymphoma; 2010 Jan;51(1):171-3
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  • [Title] Late relapse of extranodal natural killer/T cell lymphoma, nasal type, after more than ten years.
  • [MeSH-major] Killer Cells, Natural / pathology. Lymphoma, T-Cell / diagnosis. Nose Neoplasms / diagnosis

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  • (PMID = 19886846.001).
  • [ISSN] 1029-2403
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
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69. Zhang WY, Li GD, Liu WP, Ouyang Q, Ren XC, Li FY, Xu H: Features of intestinal T-cell lymphomas in Chinese population without evidence of celiac disease and their close association with Epstein-Barr virus infection. Chin Med J (Engl); 2005 Sep 20;118(18):1542-8
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  • [Title] Features of intestinal T-cell lymphomas in Chinese population without evidence of celiac disease and their close association with Epstein-Barr virus infection.
  • BACKGROUND: Intestinal T-cell lymphoma (ITCL) is a heterogeneous lymphoid neoplastic group with variable clinical and pathological features.
  • ITCL in oriental countries is different from enteropathy-type intestinal T-cell lymphoma (ETCL) in relation to celiac disease and Epstein-Barr virus (EBV).
  • The objective of this study was to investigate the clinicopathological features, immunophenotype, expression of cytotoxic molecule (TIA-1), T-cell receptor (TCR)-gamma gene rearrangement, and Epstein-Barr virus (EBV) latent infection in primary ITCL without celiac disease in Chinese.
  • METHODS: The clinical data of 42 patients were analyzed, and the patients were followed up.
  • Neoplastic cells partially expressed T-cell differentiated antigens (CD3epsilon, CD4, CD8) and NK cell associated antigen (CD56).
  • A small proportion of primary ITCLs in Chinese and extranodal NK/T-cell lymphoma of nasal type belong to the same spectrum.
  • [MeSH-major] Epstein-Barr Virus Infections / complications. Intestinal Neoplasms / pathology. Lymphoma, T-Cell / pathology
  • [MeSH-minor] Adolescent. Adult. Celiac Disease / complications. Child. Female. Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor. Humans. Immunophenotyping. In Situ Hybridization. Male. Middle Aged. RNA, Viral / genetics. Viral Matrix Proteins / genetics

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  • (PMID = 16232331.001).
  • [ISSN] 0366-6999
  • [Journal-full-title] Chinese medical journal
  • [ISO-abbreviation] Chin. Med. J.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / EBV-associated membrane antigen, Epstein-Barr virus; 0 / Epstein-Barr virus encoded RNA 1; 0 / Epstein-Barr virus encoded RNA 2; 0 / RNA, Viral; 0 / Viral Matrix Proteins
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70. Takiyama A, Nishihara H, Tateishi U, Kimura T, Wang L, Marukawa K, Itoh T, Hashino S, Nagashima K, Tanaka S: CNS lymphomatoid granulomatosis with lymph node and bone marrow involvements. Neuropathology; 2008 Dec;28(6):640-4
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  • Lymphomatoid granulomatosis (LYG) in the CNS is an uncommon lymphoproliferative disease with characteristic angiocentric lymphoreticular proliferative and granulomatous lesions exhibiting low-grade malignant potential.
  • Eight months after the initial neurological symptoms, inguinal lymph node swelling was found and histopathologically diagnosed as peripheral T-cell lymphoma.
  • Considering the clinical course, we concluded lymph node involvement of CNS-LYG, suggesting the malignant potential of CNS-LYG.
  • [MeSH-minor] Cell Nucleus Shape. Gene Rearrangement, T-Lymphocyte. Genes, T-Cell Receptor gamma. Humans. Lymphoma, T-Cell, Peripheral / pathology. Magnetic Resonance Imaging. Male. Middle Aged. Polymerase Chain Reaction. Polymorphism, Single-Stranded Conformational. T-Lymphocytes / immunology. T-Lymphocytes / pathology

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  • [CommentIn] Neuropathology. 2010 Jun;30(3):302; author reply 302-3 [20374496.001]
  • [ErratumIn] Neuropathology. 2009 Aug;29(4):520. Lei, Wang [corrected to Wang, Lei]
  • (PMID = 18410281.001).
  • [ISSN] 1440-1789
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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71. Lucantoni C, De Bonis P, Doglietto F, Esposito G, Larocca LM, Mangiola A, Martini M, Papacci F, Teofili L, Pompucci A: Primary cerebral lymphomatoid granulomatosis: report of four cases and literature review. J Neurooncol; 2009 Sep;94(2):235-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Lymphomatoid granulomatosis (LYG) is an angiocentric and angiodestructive lymphoreticular proliferation, which usually involves the lungs, but may also involve the central nervous system (CNS).
  • CONCLUSIONS: CNS-LYG is a rare disease that should be considered in the differential diagnosis of both diffuse and space-occupying cerebral lesions.
  • [MeSH-minor] Adult. Female. Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor. Herpesvirus 4, Human / genetics. Herpesvirus 4, Human / isolation & purification. Humans. Immunoglobulin Heavy Chains / genetics. Immunophenotyping. In Situ Hybridization. Male. Middle Aged

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  • (PMID = 19322520.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Immunoglobulin Heavy Chains
  • [Number-of-references] 33
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72. Meng W, Zhou Y, Zhang H, Jiang L, Wang Z, Li X, Zhou H, Chen Q, Zeng X: Nasal-type NK/T-cell lymphoma with palatal ulcer as the earliest clinical manifestation: a case report with literature review. Pathol Oncol Res; 2010 Mar;16(1):133-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nasal-type NK/T-cell lymphoma with palatal ulcer as the earliest clinical manifestation: a case report with literature review.
  • Extranodal nasal natural killer (NK)/T-cell lymphoma is a very rare kind of lymphoma, Oral cavity involvement of extranodal natural killer/T-cell lymphoma, nasal type is extremely rare, and its clinicopathologic features are also poorly understood.
  • Recently, we experienced an unusual case of Epstein-Barr virus-associated, extranodal NK/T-cell type with a unhealed palatal ulcer as the earliest clinical feature.
  • It is a challenge for oral medicine specialists to make the early diagnosis for this special type of tumor.
  • [MeSH-major] Lymphoma, Extranodal NK-T-Cell / pathology. Mouth Neoplasms / pathology. Palate / pathology. Ulcer / pathology

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  • (PMID = 19590983.001).
  • [ISSN] 1532-2807
  • [Journal-full-title] Pathology oncology research : POR
  • [ISO-abbreviation] Pathol. Oncol. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 13
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73. López-de la Cruz I, Aguayo-González A, López-Karpovitch X: [Thalidomide-associated bradycardia in patients with hematologic diseases: a single institution experience]. Rev Invest Clin; 2006 Sep-Oct;58(5):424-31
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  • [Transliterated title] Bradicardia asociada al uso de talidomida en pacientes con enfermedades hematológicas: experiencia en una sola institución.
  • In a 34-month period, 33 patients with different hematologic diseases (multiple myeloma [MM], 20; myelodysplastic syndrome, eight; Waldenström macroglobulinemia, two; non-Hodgkin's lymphoma, two; malignant histiocytosis, one) were treated with thalidomide.
  • It is concluded that: a) thalidomide-associated bradycardia was detected only in patients with MM, b) herein the incidence of bradycardia was higher as compared with other series, and c) in patients with MM thalidomide therapy must be prescribed with caution particularly in those with cardiovascular diseases of any etiology.

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  • (PMID = 17408102.001).
  • [ISSN] 0034-8376
  • [Journal-full-title] Revista de investigación clínica; organo del Hospital de Enfermedades de la Nutrición
  • [ISO-abbreviation] Rev. Invest. Clin.
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Mexico
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 4Z8R6ORS6L / Thalidomide
  • [Number-of-references] 60
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74. Yoshioka T, Harada M, Umekita Y, Taguchi S, Higashi M, Nakamura D, Suzuki S, Tanimoto A: Necrotizing sialometaplasia of the parotid gland associated with angiocentric T-cell lymphoma: a case report and review of the literature. Pathol Int; 2010 Apr;60(4):326-9
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  • [Title] Necrotizing sialometaplasia of the parotid gland associated with angiocentric T-cell lymphoma: a case report and review of the literature.
  • A very rare case of necrotizing sialometaplasia of the parotid gland associated with angiocentric T-cell lymphoma was described.
  • Angiocentric pattern or vascular invasion by the lymphoid cells was observed and the involved parotid gland exhibited squamous metaplasia of the ducts and acini; necrotizing sialometaplasia.
  • Immunohistochemical analysis revealed a cytotoxic T-cell phenotype of the lymphoid cells (CD3+, CD4-, CD5+, CD8+, CD56-, Granzyme B+, TIA-1+, Perforin-) but in situ hybridization showed no relation to Epstein-Barr virus.
  • Although necrotizing sialometaplasia is relatively rare in the parotid gland, angiocentric T-cell lymphoma should be considered for a causative condition of necrotizing sialometaplasia.
  • [MeSH-major] Lymphoma, T-Cell / pathology. Neovascularization, Pathologic / pathology. Parotid Gland / pathology. Sialometaplasia, Necrotizing / pathology

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  • (PMID = 20403036.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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75. Zhao S, Liu WP, Wang XL, Zhang WY, Jiang W, Tang Y, Li GD: [Detection of the 30 base pair deletion of Epstein-Barr virus latent membrane protein 1 in extranodal nasal type NK/T-cell lymphoma and its prognostic significance]. Zhonghua Bing Li Xue Za Zhi; 2005 Nov;34(11):720-3
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  • [Title] [Detection of the 30 base pair deletion of Epstein-Barr virus latent membrane protein 1 in extranodal nasal type NK/T-cell lymphoma and its prognostic significance].
  • OBJECTIVE: To compare the detection rate of Epstein-Barr virus latent membrane protein 1 (LMP1) 30 base pair deletion in extranodal nasal type NK/T-cell lymphoma with that in chronic inflammation of nasopharynx and tonsillitis; and to analyze the prognostic significance of LMP1 deletion in extranodal nasal type NK/T-cell lymphoma.
  • METHODS: Polymerase chain reaction was used to detect the deletion of LMP1 in 55 cases of extranodal nasal type NK/T-cell lymphoma and 19 cases of chronic inflammation of nasopharynx and tonsillitis.
  • RESULTS: In all the 55 extranodal nasal type NK/T-cell lymphoma cases studied, 9 cases contained the wide-type or predominantly wide-type LMP1.
  • In the non-lymphoma control group, 16 cases contained the deleted or predominantly deleted LMP1.
  • However, no statistically significant difference was found in the detection rate of 30 base pair deleted LMP1 between extranodal nasal type NK/T-cell lymphoma and control group (P > 0.05).
  • The prognosis of deleted or predominantly deleted LMP1 in extranodal nasal type NK/T-cell lymphoma was worse.
  • CONCLUSION: Though 30 base pair deletion of Epstein-Barr virus LMP1 may not be an important pathogenetic step in extranodal nasal type NK/T-cell lymphoma, it may play some role in tumor progression.
  • [MeSH-major] Lymphoma, T-Cell, Peripheral / genetics. Nose Neoplasms / genetics. Sequence Deletion. Viral Matrix Proteins / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Base Sequence. Epstein-Barr Virus Infections / genetics. Epstein-Barr Virus Infections / virology. Female. Follow-Up Studies. Herpesvirus 4, Human / genetics. Humans. Killer Cells, Natural / pathology. Killer Cells, Natural / virology. Male. Middle Aged. Nasopharyngitis. Survival Rate. Tonsillitis / genetics. Tonsillitis / virology

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  • (PMID = 16536316.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / EBV-associated membrane antigen, Epstein-Barr virus; 0 / Viral Matrix Proteins
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76. Chow C, Liu AY, Chan WS, Lei KI, Chan WY, Lo AW: AKT plays a role in the survival of the tumor cells of extranodal NK/T-cell lymphoma, nasal type. Haematologica; 2005 Feb;90(2):274-5
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  • [Title] AKT plays a role in the survival of the tumor cells of extranodal NK/T-cell lymphoma, nasal type.
  • Phosphorylated AKT has been detected in extranodal NK/T-cell lymphoma, nasal type (ENTL).
  • Either interleukin-2 (IL-2) or interleukin-15 (IL-15) could prevent AKT dephosphorylation and apoptosis in the NK-92 cell line model.
  • [MeSH-major] Killer Cells, Natural / cytology. Lymphoma, T-Cell / immunology. Nose Neoplasms / immunology. Proto-Oncogene Proteins c-akt / physiology
  • [MeSH-minor] Cell Line, Tumor. Cell Survival. Humans. Immunohistochemistry. Immunophenotyping. Interleukin-15 / blood. Interleukin-15 / metabolism. Interleukin-2 / metabolism. Lymphoma / pathology. Phosphorylation

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  • (PMID = 15710591.001).
  • [ISSN] 1592-8721
  • [Journal-full-title] Haematologica
  • [ISO-abbreviation] Haematologica
  • [Language] eng
  • [Publication-type] Letter; Research Support, Non-U.S. Gov't
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Interleukin-15; 0 / Interleukin-2; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt
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77. Ito T, Okubo Y, Furuhata Y, Niide M, Kawaguchi A, Yamazaki M, Iwaya K, Tsuboi R: Extranodal NK/T-cell lymphoma, nasal type, presenting after 5 years of remission. Int J Dermatol; 2008 Mar;47(3):259-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extranodal NK/T-cell lymphoma, nasal type, presenting after 5 years of remission.
  • [MeSH-major] Epstein-Barr Virus Infections / complications. Killer Cells, Natural. Lymphoma, T-Cell / pathology. Skin / pathology. Skin Neoplasms / pathology

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  • (PMID = 18289327.001).
  • [ISSN] 1365-4632
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Viral; 0 / RNA, Viral
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78. Cornejo-Juárez P, Volkow-Fernández P, Avilés-Salas A, Calderón-Flores E: AIDS and non-Hodgkin's lymphoma. Experience at an oncological center in Mexico. Rev Invest Clin; 2008 Sep-Oct;60(5):375-81
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  • [Title] AIDS and non-Hodgkin's lymphoma. Experience at an oncological center in Mexico.
  • BACKGROUND: Non-Hodgkin lymphoma (NHL) associated with HIV became an AIDS-defining condition early in the epidemic and remains the second most common malignancy in patients with AIDS.
  • Our objective was to review the clinical spectrum of patients with AIDS-associated NHL and to analyze the impact of HAART on survival at an oncological tertiary center.
  • MATERIAL AND METHODS: We reviewed all medical records and histopathologic tissue of patients with HIV-associated NHL seen from January 1990 to September 2007 at the Instituto Nacional de Cancerologia in Mexico City.
  • Survival or follow-up time was calculated from date of diagnosis to death, or to the date on which the patient was last seen.
  • RESULTS: Eighty seven HIV-positive patients were diagnosed with NHL (diffuse large B-cell lymphoma n=69; Burkitt-like n=8; pleomorphic large cell n=7; low-grade n=2, and angiocentric n=1).
  • [MeSH-major] Cancer Care Facilities / statistics & numerical data. Lymphoma, AIDS-Related / epidemiology. Lymphoma, Large B-Cell, Diffuse / epidemiology. Lymphoma, Non-Hodgkin / epidemiology

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  • (PMID = 19227434.001).
  • [ISSN] 0034-8376
  • [Journal-full-title] Revista de investigación clínica; organo del Hospital de Enfermedades de la Nutrición
  • [ISO-abbreviation] Rev. Invest. Clin.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Mexico
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79. Chia HY, Tey HL, Tan KB, Chong WS: Nasal-type extranodal natural killer/T-cell lymphoma presenting with extensive leg ulcers. Clin Exp Dermatol; 2009 Dec;34(8):e693-5
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  • [Title] Nasal-type extranodal natural killer/T-cell lymphoma presenting with extensive leg ulcers.
  • Primary cutaneous T-cell lymphomas are rare and can be difficult to classify precisely.
  • We present a case of extranodal natural killer (NK)/T-cell lymphoma in a previously healthy, immunocompetent man who presented with extensive necrotic leg ulcers and disseminated skin nodules.
  • Immunohistochemical studies revealed that the tumour cells were positive for CD3, CD30, granzyme B and T-cell intracellular antigen-1, and negative for CD5 and CD56, with positive staining for Epstein-Barr virus (EBV) RNA on in situ hybridization.
  • A diagnosis of extranodal NK/T-cell lymphoma was made, based on the presence of cytotoxic granules and positive EBV RNA staining.
  • [MeSH-major] Leg Ulcer / pathology. Lymphoma, Extranodal NK-T-Cell / pathology. Lymphoma, T-Cell, Cutaneous / pathology. Skin Neoplasms / pathology

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  • (PMID = 20055838.001).
  • [ISSN] 1365-2230
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD30; 0 / Antigens, CD56; 0 / Biomarkers, Tumor
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80. Schubert S, Abdul-Khaliq H, Lehmkuhl HB, Yegitbasi M, Reinke P, Kebelmann-Betzig C, Hauptmann K, Gross-Wieltsch U, Hetzer R, Berger F: Diagnosis and treatment of post-transplantation lymphoproliferative disorder in pediatric heart transplant patients. Pediatr Transplant; 2009 Feb;13(1):54-62
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  • [Title] Diagnosis and treatment of post-transplantation lymphoproliferative disorder in pediatric heart transplant patients.
  • It was diagnosed in 7/12 as a monomorphic B-cell lymphoma and in four patients as a monomorphic Burkitt lymphoma, a polymorphic B-cell lymphoma, a T-cell rich or angiocentric lymphoma (Liebow) and as reactive plasmacytic hyperplasia (early lesion), respectively.
  • Despite reduction of immunosuppression, treatment consisted of surgical procedures to remove tumor masses (n = 6), Rituximab (n = 5), polychemotherapy (n = 3), antiviral (n = 1) and autologous T-cell therapy (n = 1).
  • The manifestation of PTLD in pediatric heart transplant recipients is associated with EBV infection and is predominantly in the form of a B-cell lymphoma.
  • [MeSH-major] Heart Transplantation / adverse effects. Lymphoproliferative Disorders / diagnosis


81. Lan MX, Zhen ZX, Ming WH: CD56-negative extranodal nasal type of natural killer/T-cell lymphoma with extranasal skin involvement. Leuk Lymphoma; 2009 Oct;50(10):1715-7
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  • [Title] CD56-negative extranodal nasal type of natural killer/T-cell lymphoma with extranasal skin involvement.
  • [MeSH-major] Antigens, CD56 / analysis. Epstein-Barr Virus Infections / pathology. Eyelid Neoplasms / pathology. Herpesvirus 4, Human / isolation & purification. Killer Cells, Natural / pathology. Lymphoma, Non-Hodgkin / pathology. Lymphoma, T-Cell, Cutaneous / pathology. Skin / pathology. Skin Neoplasms / pathology. T-Lymphocyte Subsets / pathology
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Connective Tissue Diseases / diagnosis. Cyclophosphamide / administration & dosage. Diagnostic Errors. Doxorubicin / administration & dosage. Fatal Outcome. Female. Humans. Immunophenotyping. Male. Nose. Prednisolone / administration & dosage. Vincristine / administration & dosage. Young Adult

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  • (PMID = 19863343.001).
  • [ISSN] 1029-2403
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD56; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; 9PHQ9Y1OLM / Prednisolone; VAP-cyclo protocol
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82. Tai WC, Li HP, Lin TY, Lin CY, Wu MT: Response of extranodal natural killer/T-cell lymphoma, nasal type, to interferon-alpha, corticosteroid and narrowband ultraviolet B phototherapy. Clin Exp Dermatol; 2009 Dec;34(8):e927-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Response of extranodal natural killer/T-cell lymphoma, nasal type, to interferon-alpha, corticosteroid and narrowband ultraviolet B phototherapy.
  • Extranodal natural killer (NK)/T-cell lymphoma, nasal type (ENKTLN), is characterized by higher prevalence in East Asians and South Americans, association with Epstein-Barr virus infection, aggressive nature in most cases, and resistance to conventional treatment strategies such as chemotherapy and radiotherapy.
  • [MeSH-major] Interferon-alpha / administration & dosage. Lymphoma, T-Cell / therapy. Nose Neoplasms / therapy
  • [MeSH-minor] Combined Modality Therapy. Female. Humans. Middle Aged. Natural Killer T-Cells / pathology. Phototherapy. Treatment Outcome

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  • (PMID = 20055869.001).
  • [ISSN] 1365-2230
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Interferon-alpha
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83. Nishihara H, Tateishi U, Itoh T, Nagashima K, Tanaka S: Immunohistochemical and gene rearrangement studies of central nervous system lymphomatoid granulomatosis. Neuropathology; 2007 Oct;27(5):413-8
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  • Lymphomatoid granulomatosis (LYG) is a rare multisystem disorder with characteristic angiocentric lymphoproliferative features, most frequently involving the lung, skin, and rarely the CNS.
  • Most systemic LYGs have been shown to be EBV-associated, T-cell rich, B-cell proliferative disorders.
  • Here, we present four cases of LYG arising from the CNS and have analyzed them by immunohistochemistry to assess the phenotype of the infiltrate, and by PCR-SSCP (single-strand conformation polymorphism) analysis for immunoglobulin heavy chain (IgH) and T-cell receptor (TcR) gamma gene rearrangements.
  • Three cases revealed perivascular infiltration of T-cell dominant lymphoid cells, two cases showed monoclonal TcRgamma gene rearrangement, while the remaining case had a B-cell immunophenotype and monoclonal IgH gene rearrangement with EBV genome expression.
  • This is the first report of a gene rearrangement study on CNS-LYG.
  • We confirm that some cases of CNS-LYG are derived from T-cell monoclonal lymphoproliferative disease, although this disease should be classified as a borderline malignancy and should be separated from overt malignant lymphoma of CNS.
  • [MeSH-major] Central Nervous System Diseases / pathology. Gene Rearrangement. Genes, T-Cell Receptor gamma. Immunoglobulin Heavy Chains / genetics. Lymphomatoid Granulomatosis / pathology
  • [MeSH-minor] Antigens, CD / analysis. Humans. Immunohistochemistry. In Situ Hybridization. Phenotype. Polymerase Chain Reaction. Polymorphism, Single-Stranded Conformational. Receptors, Antigen, T-Cell, gamma-delta / genetics

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  • (PMID = 18018473.001).
  • [ISSN] 0919-6544
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Immunoglobulin Heavy Chains; 0 / Receptors, Antigen, T-Cell, gamma-delta
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84. Lee SR, Park EK, Won NH, Kim BS: Esophageal involvement by extranodal natural killer T cell lymphoma, nasal type, mimicking Ebstein Barr viral esophagitis in a tonsillar lymphoma patient undergoing chemoradiation therapy. Asia Pac J Clin Oncol; 2010 Sep;6(3):149-54
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  • [Title] Esophageal involvement by extranodal natural killer T cell lymphoma, nasal type, mimicking Ebstein Barr viral esophagitis in a tonsillar lymphoma patient undergoing chemoradiation therapy.
  • Esophageal involvement by extranodal natural killer (NK)/T cell lymphoma, nasal type, is rare.
  • It is important to note, however, that benign conditions may mask esophageal involvement by lymphoma.
  • Until now, there has been no report documenting esophageal involvement by lymphoma mimicking viral esophagitis in an extranodal NK/T cell lymphoma patient undergoing active treatment.
  • Here, we report a case of esophageal involvement by extranodal NK/T cell lymphoma, nasal type, initially misdiagnosed as Ebstein Barr virus esophagitis.
  • Lymphoma invasion of the esophagus should be considered if esophageal symptoms do not respond to usual medical esophagitis therapy in an extranodal NK/T cell lymphoma, nasal type, patient undergoing chemoradiation.
  • [MeSH-major] Epstein-Barr Virus Infections / pathology. Esophageal Neoplasms / pathology. Esophagitis / pathology. Lymphoma, Extranodal NK-T-Cell / pathology
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Combined Modality Therapy. Diagnosis, Differential. Humans. Male. Middle Aged. Radiotherapy. Tonsillar Neoplasms / pathology. Tonsillar Neoplasms / therapy

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  • (PMID = 20887494.001).
  • [ISSN] 1743-7563
  • [Journal-full-title] Asia-Pacific journal of clinical oncology
  • [ISO-abbreviation] Asia Pac J Clin Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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85. Zhang S, Nong L, Zhang Y, Wang Y, Li T: [Expression of natural killer cell development-associated transcription factors in nasal NK/T-cell lymphomas occurring in Chinese population]. Zhonghua Bing Li Xue Za Zhi; 2010 Jun;39(6):366-71
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  • [Title] [Expression of natural killer cell development-associated transcription factors in nasal NK/T-cell lymphomas occurring in Chinese population].
  • OBJECTIVE: To evaluate the expression and prognostic significance of T-bet and its cofactors EOMES, ETS-1 and MEF [which are transcription factors and responsible for development of natural killer (NK) cells] in the extranodal NK/T-cell lymphoma, nasal type (EN-NK/T-NT).
  • METHODS: The expression status of T-bet, EOMES, ETS-1 and MEF in 40 cases of EN-NK/T-NT occurring in Chinese population was studied by immunohistochemistry and in-situ hybridization (ISH).
  • The clinical relevance was also evaluated.
  • The control cases included 18 cases of peripheral T-cell lymphoma, 10 cases of B-cell lymphoma, 5 cases of normal spleen, 5 cases of normal thymus and 10 cases of nasal mucosal tissues affected by chronic inflammation.
  • RESULTS: The expression levels of T-bet mRNA and protein were high in EN-NK/T-NT (82.5% and 100%, respectively) and in peripheral T cell lymphoma (17/18 and 72.2%, respectively).
  • There was no expression in B-cell lymphoma.
  • The expression of EOMES (80.0% by ISH), ETS-1 (82.5% by ISH) and MEF (62.5% by ISH) was high in EN-NK/T-NT, but not in the control group.
  • The frequency of co-expression of T-bet and EOMES (75%, 30/40) was significantly higher than that of the other genes.
  • Follow-up study showed that the mean and median survival of the 19 cases of EN-NK/ T-NT was 33 months and 10 months, respectively.
  • The expression rates of T-bet, EOMES, ETS-1 or MEF had no significant difference between the 9 alive and the 10 dead cases.
  • CONCLUSIONS: The expression of T-bet correlates with the lymphoma types.
  • It is mainly expressed in peripheral NK and T-cell lymphomas.
  • The important functional gene engaged in NK cells development is highly expressed in EN-NK/T-NT.
  • [MeSH-minor] Adolescent. Adult. Aged. China / epidemiology. Female. Follow-Up Studies. Humans. Lymphoma, Extranodal NK-T-Cell. Lymphoma, T-Cell, Peripheral / metabolism. Male. Middle Aged. RNA, Messenger / metabolism. Survival Rate. Young Adult

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  • (PMID = 21055151.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / ELF4 protein, human; 0 / EOMES protein, human; 0 / Proto-Oncogene Protein c-ets-1; 0 / RNA, Messenger; 0 / T-Box Domain Proteins; 0 / T-box transcription factor TBX21; 0 / Transcription Factors
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86. Patel V, Mahajan S, Kharkar V, Khopkar U: Nasal extranodal NK/T-cell lymphoma presenting as a perforating palatal ulcer: a diagnostic challenge. Indian J Dermatol Venereol Leprol; 2006 May-Jun;72(3):218-21
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  • [Title] Nasal extranodal NK/T-cell lymphoma presenting as a perforating palatal ulcer: a diagnostic challenge.
  • A 40-year-old man presented with chronic nasal stuffiness and bloodstained discharge of 3 years' duration, along with a non-healing palatal ulcer since 2 months.
  • Examination revealed a perforation in the midline on the hard palate and a superficial ulcer on the soft palate.
  • Histopathology and immunohistochemistry suggested a diagnosis of extranodal nasal/nasal-type T-cell lymphoma.
  • Only one case of nasal T cell lymphoma presenting as nasal septal perforation, oronasal fistula and a concomitant palatal ulcer has been described.
  • We report this case of a perforating palatal ulcer as a rare presentation of nasal lymphoma.
  • [MeSH-major] Lymphoma, T-Cell / diagnosis. Lymphoma, T-Cell / pathology. Mouth Diseases / pathology. Nose Neoplasms / diagnosis. Oral Ulcer / pathology
  • [MeSH-minor] Adult. Fatal Outcome. Humans. Killer Cells, Natural / pathology. Male. Mouth Neoplasms / diagnosis. Mouth Neoplasms / pathology

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  • (PMID = 16766838.001).
  • [ISSN] 0378-6323
  • [Journal-full-title] Indian journal of dermatology, venereology and leprology
  • [ISO-abbreviation] Indian J Dermatol Venereol Leprol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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87. Kim K, Chie EK, Kim CW, Kim IH, Park CI: Treatment outcome of angiocentric T-cell and NK/T-cell lymphoma, nasal type: radiotherapy versus chemoradiotherapy. Jpn J Clin Oncol; 2005 Jan;35(1):1-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Treatment outcome of angiocentric T-cell and NK/T-cell lymphoma, nasal type: radiotherapy versus chemoradiotherapy.
  • OBJECTIVE: The purpose of this study was to evaluate the treatment outcome of angiocentric T-cell and natural killer (NK)/T-cell lymphoma, nasal type.
  • METHODS: Between February 1989 and March 2001, 53 patients with newly diagnosed angiocentric T-cell and NK/T-cell lymphoma, nasal type involving the head and neck, were treated with radiation therapy (RT).
  • CONCLUSIONS: There was no difference in survival between RT and CRT in angiocentric T-cell and NK/T-cell lymphoma, nasal type.
  • [MeSH-major] Killer Cells, Natural. Lymphoma, T-Cell / drug therapy. Lymphoma, T-Cell / radiotherapy. Nose Neoplasms / drug therapy. Nose Neoplasms / radiotherapy

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  • (PMID = 15681596.001).
  • [ISSN] 0368-2811
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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88. Coomer AR, Liptak JM: Canine histiocytic diseases. Compend Contin Educ Vet; 2008 Apr;30(4):202-4, 208-16; quiz 216-17
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  • [Title] Canine histiocytic diseases.
  • Canine histiocytic diseases are an emerging spectrum of diseases characterized by proliferations of histiocytic cells.
  • Nonneoplastic histiocytic disease (reactive histiocytosis, comprising cutaneous and systemic histiocytosis) is uncommon.
  • Neoplastic histiocytic diseases include cutaneous histiocytoma, which is a benign histiocytic tumor, and localized and disseminated histiocytic sarcoma (previously known as malignant histiocytosis), which are malignant diseases.
  • The differentiation of histiocytic diseases can be challenging.
  • [MeSH-major] Dog Diseases / diagnosis. Histiocytoma / veterinary. Histiocytosis / veterinary. Skin Diseases / veterinary. Skin Neoplasms / veterinary
  • [MeSH-minor] Animals. Diagnosis, Differential. Dogs. Immunohistochemistry / veterinary. Prognosis

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  • (PMID = 18576276.001).
  • [ISSN] 1940-8307
  • [Journal-full-title] Compendium (Yardley, PA)
  • [ISO-abbreviation] Compend Contin Educ Vet
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 41
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89. Guerrero-Palma MA, Avila-Espín L, González-Pérez JM, Moreno-León JA, Fernández-Pérez A, Prieto Sánchez E: [Unusual nasal clinical entities]. Acta Otorrinolaringol Esp; 2007 Dec;58(10):483-6
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  • [Title] [Unusual nasal clinical entities].
  • Three cases of rare entities in nasal pathology are reported.
  • Two of them are high-grade lymphomas (T/NK type), with nasal blockage as the first symptom.
  • Clinical course and treatment response are described.
  • The third case refers to an infrequent benign nasal entity called angiocentric eosinophilic fibrosis.
  • [MeSH-major] Eosinophilia / complications. Eosinophilia / pathology. Fibrosis / complications. Fibrosis / pathology. Lymphoma, Non-Hodgkin / pathology. Paranasal Sinus Diseases / complications. Paranasal Sinus Diseases / pathology
  • [MeSH-minor] Adult. Aged. Antigens, CD56 / metabolism. Female. Humans. Killer Cells, Natural / metabolism. Male. Maxillary Sinus / metabolism. Maxillary Sinus / pathology. T-Lymphocytes / metabolism

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  • (PMID = 18082079.001).
  • [ISSN] 0001-6519
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Antigens, CD56
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90. Papalkar D, Sharma S, Francis IC, Downie JA, Thanakrishnan G, Hughes LJ: A rapidly fatal case of T-cell lymphoma presenting as idiopathic orbital inflammation. Orbit; 2005 Jun;24(2):131-3
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  • [Title] A rapidly fatal case of T-cell lymphoma presenting as idiopathic orbital inflammation.
  • Post-mortem examination demonstrated widespread extranodal NK/T- cell lymphoma (nasal type), involving the right posterior orbit, lungs, uterus, left adrenal gland, pericardium and meninges.
  • [MeSH-major] Diagnostic Errors. Lymphoma, T-Cell / diagnosis. Orbital Neoplasms / diagnosis
  • [MeSH-minor] Adult. Fatal Outcome. Female. Humans. Inflammation. Killer Cells, Natural / immunology. Neoplasm Metastasis. T-Lymphocytes

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  • (PMID = 16191803.001).
  • [ISSN] 0167-6830
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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91. Wang B, Lu JJ, Ma X, Guo Y, Lu H, Hong X, Li J: Combined chemotherapy and external beam radiation for stage IE and IIE natural killer T-cell lymphoma of nasal cavity. Leuk Lymphoma; 2007 Feb;48(2):396-402
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  • [Title] Combined chemotherapy and external beam radiation for stage IE and IIE natural killer T-cell lymphoma of nasal cavity.
  • To evaluate the outcome of CHOP chemotherapy and radiotherapy in Stage IE and IIE nasal natural killer (NK)/T-cell lymphoma, 53 patients with stage IE and IIE nasal NK/T-cell lymphoma were studied.
  • By the Ann Arbor Lymphoma Staging Classification, 41 patients (77%) had Stage IE disease and 12 patients (23%) had Stage IIE disease.
  • Combined chemotherapy followed by involved field radiation produced suboptimal outcome for patients with early stage nasal NK/T-cell lymphoma.
  • Further investigations, preferably prospective clinical trials, for more efficacious treatment strategies are needed to improve the treatment outcome of this malignancy.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Killer Cells, Natural / pathology. Lymphoma, T-Cell / therapy. Nose Neoplasms / therapy

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  • (PMID = 17325902.001).
  • [ISSN] 1042-8194
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CHOP protocol
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92. Li Z, Liu WP, Tang Y, Jiang LL, Zhang WY, Bi CF, Li GD: [Splenic T-cell and NK-cell lymphomas: a clinicopathologic and immunophenotypic analysis of 9 cases]. Zhonghua Xue Ye Xue Za Zhi; 2007 Apr;28(4):217-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Splenic T-cell and NK-cell lymphomas: a clinicopathologic and immunophenotypic analysis of 9 cases].
  • OBJECTIVE: To explore the clinicopathologic features and diagnosis of splenic T-cell and NK-cell neoplasms.
  • METHODS: Nine cases of splenic T-cell and NK-cell neoplasms were collected and studied by morphology, immunophenotyping, EBER in situ hybridization and TCR-gamma gene rearrangement.
  • RESULTS: Among the 9 cases, hepatosplenic T-cell lymphoma (HSTCL) and extranodal nasal type NK/T-cell lymphoma (NK/TCL) were both of 4 cases, and the remaining one was peripheral T-cell lymphoma, unspecified (PTL, unspecified).
  • Five patients including 2 with HSTCL, 2 with extranodal nasal type NK/TCL and one with PTL, unspecified died, with survival times ranged from 1 to 10 months.
  • The other two patients are still alive, one with NK/TCL (two months+) and one with HSTCL (14+ months).
  • CONCLUSION: Splenic T-cell and NK-cell neoplasms are a group of uncommon lymphomas with heterogeneous clinicopathologic features and poor prognosis.
  • A definite diagnosis must depend on clinical manifestations, histopathology, immunophenotype and TCR gene rearrangement analysis.
  • [MeSH-major] Lymphoma, Extranodal NK-T-Cell / pathology. Lymphoma, T-Cell, Peripheral / pathology. Splenic Neoplasms / pathology

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  • (PMID = 17877195.001).
  • [ISSN] 0253-2727
  • [Journal-full-title] Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
  • [ISO-abbreviation] Zhonghua Xue Ye Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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93. Wu X, Li P, Zhao J, Yang X, Wang F, Yang YQ, Fang F, Xu Y, Zhang H, Wang WY, Yi C: A clinical study of 115 patients with extranodal natural killer/T-cell lymphoma, nasal type. Clin Oncol (R Coll Radiol); 2008 Oct;20(8):619-25
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A clinical study of 115 patients with extranodal natural killer/T-cell lymphoma, nasal type.
  • AIMS: To investigate the clinicopathological features, treatment outcomes, and prognostic factors in patients with extranodal natural killer (NK)/T-cell lymphoma, nasal type.
  • MATERIALS AND METHODS: We retrospectively reviewed the medical records of 115 patients diagnosed with extranodal NK/T-cell lymphoma, nasal type who were admitted to our hospital between January 1991 and June 2006.
  • CONCLUSIONS: The prognosis of extranodal NK/T-cell lymphoma, nasal type is poor and significantly influenced by B symptoms, gender, IPI score, clinical staging and the method of treatment.
  • [MeSH-major] Lymphoma, Extranodal NK-T-Cell / therapy. Nose Neoplasms / therapy

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  • (PMID = 18790372.001).
  • [ISSN] 0936-6555
  • [Journal-full-title] Clinical oncology (Royal College of Radiologists (Great Britain))
  • [ISO-abbreviation] Clin Oncol (R Coll Radiol)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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94. Susarla SM, Sharaf BA, Faquin W, Hasserjian RP, McDermott N, Lahey E: Extranodal natural killer T-cell lymphoma, nasal type, with minimal osseous involvement: report of a case and literature review. J Oral Maxillofac Surg; 2010 Mar;68(3):674-81
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  • [Title] Extranodal natural killer T-cell lymphoma, nasal type, with minimal osseous involvement: report of a case and literature review.
  • [MeSH-major] Facial Neoplasms / pathology. Lymphoma, Extranodal NK-T-Cell / pathology
  • [MeSH-minor] Diagnosis, Differential. Female. Herpesvirus 4, Human / genetics. Humans. Middle Aged. RNA, Viral / analysis. Tomography, X-Ray Computed

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  • (PMID = 19959270.001).
  • [ISSN] 1531-5053
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Viral
  • [Number-of-references] 26
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95. Miyoshi I, Daibata M, Saito T, Mitsuoka T, Kuroda N, Ohtsuki Y, Taguchi H: Nasal T-cell lymphoma. Intern Med; 2006;45(8):569-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nasal T-cell lymphoma.
  • [MeSH-major] Lymphoma, T-Cell / diagnosis. Nasal Cavity. Nose Neoplasms / diagnosis

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  • (PMID = 16702756.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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96. Gill H, Liang RH, Tse E: Extranodal natural-killer/t-cell lymphoma, nasal type. Adv Hematol; 2010;2010:627401
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  • [Title] Extranodal natural-killer/t-cell lymphoma, nasal type.
  • The World Health Organization (WHO) classification recognizes 2 main categories of natural killer (NK) cell-derived neoplasms, namely, extranodal NK/T-cell lymphoma, nasal type, and aggressive NK-cell leukaemia.
  • Extranodal nasal NK/T-cell lymphoma is more frequent in the Far East and Latin America.
  • Early stage disease, in particular for localized lesion in the nasal region, is treated with chemotherapy and involved-field radiotherapy.
  • The role of autologous hematopoietic stem cell transplantation is yet to be clearly defined.
  • Allogeneic hematopoietic stem cell transplantation, with the putative graft-versus-lymphoma effect, offers a potentially curative option in patients with advanced disease.

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  • (PMID = 21234094.001).
  • [ISSN] 1687-9112
  • [Journal-full-title] Advances in hematology
  • [ISO-abbreviation] Adv Hematol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3018635
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97. Paik YS, Liess BD, Scheidt TD, Ingram EA, Zitsch RP 3rd: Extranodal nasal-type natural killer/T-cell lymphoma masquerading as recalcitrant sinusitis. Head Neck; 2010 Feb;32(2):268-73
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extranodal nasal-type natural killer/T-cell lymphoma masquerading as recalcitrant sinusitis.
  • BACKGROUND: Extranodal nasal-type natural killer (NK)/T-cell lymphoma is a very uncommon disease process often mimicking refractory sinusitis.
  • The diagnosis may be discovered after an extensive exclusion process.
  • Careful immunohistochemical evaluation is crucial to differentiate NK/T-cell lymphoma from other malignancies.
  • Immunohistopathology demonstrated extranodal nasal-type NK/T-cell lymphoma.
  • CONCLUSION: Severe recalcitrant sinusitis with orbital involvement may be the initial presentation of NK/T-cell lymphoma.
  • Ulcerative or necrotic lesions in the midline of the head and neck should raise concern for this disease.
  • In addition to radiographic and laboratory testing, large biopsies should be taken for immunohistochemical analysis to achieve diagnosis and guide further management.
  • [MeSH-major] Lymphoma, Extranodal NK-T-Cell / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Facial Pain / etiology. Facial Paralysis / etiology. Fatal Outcome. Hearing Loss, Conductive / etiology. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Necrosis. Sinusitis / diagnosis. Tomography, X-Ray Computed. Vision Disorders / etiology. Visual Fields

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  • [Copyright] Copyright 2009 Wiley Periodicals, Inc.
  • (PMID = 19360743.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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98. Kako S, Izutsu K, Oshima K, Sato H, Kanda Y, Motokura T, Chiba S, Kurokawa M: Regression of the tumor after withdrawal of cyclosporine in relapsed extranodal natural killer/T cell lymphoma following allogeneic hematopoietic stem cell transplantation. Am J Hematol; 2007 Oct;82(10):937-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Regression of the tumor after withdrawal of cyclosporine in relapsed extranodal natural killer/T cell lymphoma following allogeneic hematopoietic stem cell transplantation.
  • The prognosis of patients with advanced-stage extranodal natural killer/T cell lymphoma, nasal type (ENKL) has been generally poor, and several anecdotal reports have suggested the role of allogeneic hematopoietic stem cell transplantation (HSCT).
  • A potential advantage of allogeneic HSCT may be the graft-versus-lymphoma (GVL) effect.
  • Here we report a patient with advanced-stage ENKL who underwent allogeneic HSCT from an HLA one-allele mismatched related donor, whose clinical course after HSCT suggested the potent GVL effect against ENKL.
  • Except for a temporal exacerbation of bronchiolitis obliterans organizing pneumonia, she has been free from disease for more than a year without other treatments against lymphoma.
  • The clinical course of the current patient suggests the potent GVL effect against ENKL.
  • [MeSH-major] Cyclosporine / adverse effects. Hematopoietic Stem Cell Transplantation. Immunosuppressive Agents / adverse effects. Lymphoma, T-Cell, Peripheral / surgery. Neoplasm Recurrence, Local / pathology. Palatal Neoplasms / surgery

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  • Hazardous Substances Data Bank. CYTARABINE .
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  • (PMID = 17663389.001).
  • [ISSN] 0361-8609
  • [Journal-full-title] American journal of hematology
  • [ISO-abbreviation] Am. J. Hematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Immunosuppressive Agents; 04079A1RDZ / Cytarabine; 5J49Q6B70F / Vincristine; 6PLQ3CP4P3 / Etoposide; 7S5I7G3JQL / Dexamethasone; 80168379AG / Doxorubicin; 83HN0GTJ6D / Cyclosporine; 8N3DW7272P / Cyclophosphamide; BG3F62OND5 / Carboplatin; UM20QQM95Y / Ifosfamide; YL5FZ2Y5U1 / Methotrexate; CVAD protocol
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99. Shimada K, Suzuki R: Concurrent chemoradiotherapy for limited-stage extranodal natural killer/t-cell lymphoma, nasal type. J Clin Oncol; 2010 May 10;28(14):e229; author reply e230
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Concurrent chemoradiotherapy for limited-stage extranodal natural killer/t-cell lymphoma, nasal type.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Lymphoma, Extranodal NK-T-Cell / drug therapy. Lymphoma, Extranodal NK-T-Cell / radiotherapy

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  • [CommentOn] J Clin Oncol. 2009 Dec 10;27(35):6027-32 [19884539.001]
  • [CommentOn] J Clin Oncol. 2009 Nov 20;27(33):5594-600 [19805668.001]
  • (PMID = 20351319.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
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100. Makarov NA, Gorfinkel' AN: [Malignant histocytosis]. Klin Med (Mosk); 2006;84(12):60-1
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Malignant histocytosis].
  • A case of malignant histiocytosis, a rare disease belonging to the group ofmacrophageal leucoses, was analyzed.
  • Specific clinical symptoms including fever, hepatosplenomegalia, and hematological changes, were noted.
  • The authors adduce the stages of diagnostic search from the onset of the disease to the moment the diagnosis was made, and outline the scope of disease included into differential diagnostics.
  • [MeSH-major] Histiocytic Sarcoma / pathology. Liver / pathology

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  • (PMID = 17294888.001).
  • [ISSN] 0023-2149
  • [Journal-full-title] Klinicheskaia meditsina
  • [ISO-abbreviation] Klin Med (Mosk)
  • [Language] rus
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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