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Items 1 to 41 of about 41
1. Nagamatsu K, Kumabe T, Watanabe M, Nakazato Y, Tominaga T: Differentiation of clear cell ependymoma of the cerebellum from hemangioblastoma by thallium-201 single photon emission computed tomography-case report-. Neurol Med Chir (Tokyo); 2009 Dec;49(12):608-11
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  • [Title] Differentiation of clear cell ependymoma of the cerebellum from hemangioblastoma by thallium-201 single photon emission computed tomography-case report-.
  • Magnetic resonance imaging demonstrated a cystic tumor with a homogeneously enhanced mural nodule located in the cerebellar vermis.
  • These findings were compatible with hemangioblastoma.
  • Thallium-201 single photon emission computed tomography ((201)Tl-SPECT) showed moderately high uptake in the early phase and moderately high retention in the delayed phase, whereas hemangioblastoma shows almost no retention in the delayed phase.
  • The histological diagnosis was clear cell ependymoma (CCE).
  • CCE is a rare subtype of ependymoma, which resembles hemangioblastoma in histological and neuroimaging findings, but is considerably more aggressive. (201)Tl-SPECT can provide useful information for the preoperative differential diagnosis of infratentorial CCE and hemangioblastoma.
  • [MeSH-major] Cerebellar Neoplasms / radionuclide imaging. Cerebellum / radionuclide imaging. Ependymoma / radionuclide imaging. Hemangioblastoma / radionuclide imaging. Thallium Radioisotopes. Tomography, Emission-Computed, Single-Photon / methods
  • [MeSH-minor] Ataxia / etiology. Diagnosis, Differential. Dizziness / etiology. Humans. Male. Middle Aged. Neurosurgical Procedures. Predictive Value of Tests. Prognosis. Treatment Outcome

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  • (PMID = 20035139.001).
  • [ISSN] 1349-8029
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Thallium Radioisotopes
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2. Amano T, Tokunaga S, Shono T, Mizoguchi M, Matsumoto K, Yoshida F, Sasaki T: Cerebellar hemangioblastoma manifesting as hearing disturbance. Neurol Med Chir (Tokyo); 2009 Sep;49(9):418-20
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  • [Title] Cerebellar hemangioblastoma manifesting as hearing disturbance.
  • A 49-year-old man presented with a rare case of cerebellar hemangioblastoma manifesting as only hearing disturbance.
  • Cerebral angiography disclosed a vascular-rich tumor fed by both the superior cerebellar and anterior inferior cerebellar arteries.
  • En bloc resection of the tumor was planned under a preoperative diagnosis of cerebellar hemangioblastoma.
  • The histological diagnosis was hemangioblastoma.
  • Cerebellar hemangioblastoma should be considered in the differential diagnosis of CP angle tumors associated with hearing disturbance.
  • [MeSH-major] Cerebellar Neoplasms / complications. Cerebellar Neoplasms / pathology. Hemangioblastoma / complications. Hemangioblastoma / pathology. Vestibulocochlear Nerve Diseases / etiology. Vestibulocochlear Nerve Diseases / pathology

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  • (PMID = 19779288.001).
  • [ISSN] 1349-8029
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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3. Yanagawa Y, Shimazaki H, Shima K, Isoda S, Maehara T: Atrial myxoma occurring 15 years after subtotal resection of cerebellar hemangioblastoma. Neurol Med Chir (Tokyo); 2008 Jan;48(1):37-9
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  • [Title] Atrial myxoma occurring 15 years after subtotal resection of cerebellar hemangioblastoma.
  • A 51-year-old female, with a past medical history of resection of cerebellar hemangioblastoma, presented with an atrial tumor detected by sonography after undergoing a series of examinations for fever of unknown origin and subsequent symptoms of heart failure.
  • Immunohistopathological study showed that the tumor cells in both the hemangioblastoma and the myxoma had strong cytoplasmic immunoreactivity for vascular endothelial growth factor.
  • Hemangioblastoma associated with myxoma is extremely rare, and was probably a random occurrence in this case.
  • [MeSH-major] Cerebellar Neoplasms / surgery. Heart Neoplasms / diagnosis. Hemangioblastoma / surgery. Myxoma / diagnosis. Neoplasms, Second Primary / diagnosis

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  • (PMID = 18219192.001).
  • [ISSN] 0470-8105
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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4. Myong NH, Park BJ: Malignant glioma arising at the site of an excised cerebellar hemangioblastoma after irradiation in a von Hippel-Lindau disease patient. Yonsei Med J; 2009 Aug 31;50(4):576-81
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  • [Title] Malignant glioma arising at the site of an excised cerebellar hemangioblastoma after irradiation in a von Hippel-Lindau disease patient.
  • We describe herein a malignant glioma arising at the site of the resected hemangioblastoma after irradiation in a patient with von Hippel-Lindau disease (VHL).
  • The patient was a 25 year-old male with multiple hemangioblastomas at the cerebellum and spinal cord, multiple pancreatic cysts and a renal cell carcinoma; he was diagnosed as having VHL disease.
  • The largest hemangioblastoma at the right cerebellar hemisphere was completely removed, and he received high-dose irradiation postoperatively.
  • The tumor recurred at the same site 7 years later, which was a malignant glioma with no evidence of hemangioblastoma.
  • The genetic study to find the loss of heterozygosity (LOH) of VHL gene revealed that only the cerebellar hemangioblastoma showed allelic losses for the gene.
  • To the best of our knowledge, this report is the first to show a malignant glioma that developed in a patient with VHL disease after radiation therapy at the site of an excised hemangioblastoma.
  • [MeSH-major] Cerebellar Neoplasms / surgery. Glioma / diagnosis. Glioma / etiology. Hemangioblastoma / surgery. Radiotherapy / adverse effects. von Hippel-Lindau Disease / radiotherapy

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  • [Cites] Br J Neurosurg. 1999 Oct;13(5):504-7 [10627785.001]
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  • (PMID = 19718409.001).
  • [ISSN] 1976-2437
  • [Journal-full-title] Yonsei medical journal
  • [ISO-abbreviation] Yonsei Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2730623
  • [Keywords] NOTNLM ; Cerebellar neoplasms / hemangioblastoma / malignant glioma / radiation / von Hippel-Lindau disease
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5. Wang Y, Wang Y, Gao X, Wang Y: Intraoperative sonographically guided resection of hemangioblastoma in the cerebellum. J Clin Ultrasound; 2006 Jun;34(5):247-9
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  • [Title] Intraoperative sonographically guided resection of hemangioblastoma in the cerebellum.
  • We report a case of hemangioblastoma in a 37-year-old woman.
  • We recommend real-time intraoperative sonography as a routine procedure in the surgical treatment of hemangioblastoma.
  • [MeSH-major] Cerebellar Neoplasms / surgery. Cerebellum / surgery. Cerebellum / ultrasonography. Hemangioblastoma / surgery. Intraoperative Care / methods

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  • (PMID = 16673369.001).
  • [ISSN] 0091-2751
  • [Journal-full-title] Journal of clinical ultrasound : JCU
  • [ISO-abbreviation] J Clin Ultrasound
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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6. Agrawal A, Kakani A, Vagh SJ, Hiwale KM, Kolte G: Cystic hemangioblastoma of the brainstem. J Neurosci Rural Pract; 2010 Jan;1(1):20-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cystic hemangioblastoma of the brainstem.
  • Hemangioblastomas are very highly vascular neoplasm with benign characteristics and; in comparison to cerebellar hemangioblastoma; cases of cystic hemangioblastoma of the brain stem are rare with only a few case reports available in the literature.

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  • (PMID = 21799613.001).
  • [ISSN] 0976-3155
  • [Journal-full-title] Journal of neurosciences in rural practice
  • [ISO-abbreviation] J Neurosci Rural Pract
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3137827
  • [Keywords] NOTNLM ; Cystic hemangioblastoma / fourth ventricle / hemangioblastoma / medulla oblongata
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7. Arkadopoulos N, Karapanos K, Stafyla V, Yiallourou A, Koureas A, Kondi-Pafiti A, Smyrniotis V: Combination of right nephrectomy and total pancreaticoduodenectomy for Von Hippel-Lindau disease. JOP; 2010;11(3):270-2
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  • CASE REPORT: We report the case of a 56-year-old patient who had a past history of cerebellar hemangioblastoma and presented with abdominal pain.

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  • (PMID = 20442526.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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8. Lee SH, Park BJ, Kim TS, Lim YJ: Long-term follow-up clinical courses of cerebellar hemangioblastoma in von hippel-lindau disease : two case reports and a literature review. J Korean Neurosurg Soc; 2010 Sep;48(3):263-7

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  • [Title] Long-term follow-up clinical courses of cerebellar hemangioblastoma in von hippel-lindau disease : two case reports and a literature review.
  • Although cerebellar hemangioblastomas are histopathologically benign, they yield a degree of malignant clinical behavior in long-term follow-up.
  • We present two cases of long-term progression of renal cell carcinoma, which had been diagnosed as renal cysts during treatment for cerebellar hemangioblastoma.
  • A 14-year-old male with von Hippel-Lindau disease was admitted for a cerebellar hemangioblastoma with multiple spinal hemangioblastomas and a renal cyst.
  • After primary total resection of the cerebellar hemangioblastoma, the patient required two further surgeries after 111 and 209 months for a recurrent cerebellar hemangioblastoma.
  • Furthermore, he underwent radical nephrectomy as his renal cyst had progressed to renal cell carcinoma 209 months after initial diagnosis.
  • A 26-year-old male presented with multiple cerebellar hemangioblastomas associated with von Hippel-Lindau disease and accompanied by multiple spinal hemangioblastomas and multiple cystic lesions in the liver, kidney, and pancreas.
  • He underwent primary resection of the cerebellar hemangioblastoma in association with craniospinal radiation for multiple intracranial/spinal masses.
  • Unexpectedly, a malignant glioma developed 83 months after discovery of the cerebellar hemangioblastoma.
  • In the view of long term clinical course, cerebellar hemangioblastoma associated with von Hipple-Lindau disease may redevelop even after primary total resection.

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  • (PMID = 21082056.001).
  • [ISSN] 1598-7876
  • [Journal-full-title] Journal of Korean Neurosurgical Society
  • [ISO-abbreviation] J Korean Neurosurg Soc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2966730
  • [Keywords] NOTNLM ; Cerebellar hemangioblastoma / Renal cell carcinoma / Renal cyst / von Hippel-Lindau disease
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9. Lee JY, Cho BM, Oh SM, Park SH: Delayed diagnosis of cerebellar hemangioblastoma after intracerebellar hemorrhage. Surg Neurol; 2007 Apr;67(4):419-21
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  • [Title] Delayed diagnosis of cerebellar hemangioblastoma after intracerebellar hemorrhage.
  • BACKGROUND: Cerebellar hemorrhage caused by cerebellar hemangioblastoma is not a frequent case.
  • We report a case of solid, cerebellar hemangioblastoma, diagnosed 4 years after cerebellar hemorrhage.
  • He had a 4-year history of evacuation of cerebellar hemorrhage.
  • Gadolinium-enhanced MRI revealed a well-enhancing mass in the left cerebellar hemisphere, and vertebral angiography revealed hypervascularity.
  • CONCLUSION: In cases of spontaneous cerebellar hemorrhage, particularly in the patient without hypertension or other underlying diseases related to bleeding from tumor, cerebellar hemangioblastoma should be suspected as a rare cause of hemorrhage, and computed tomography and/or MRI with contrast administration is mandatory for differential diagnosis.
  • [MeSH-major] Cerebellar Neoplasms / complications. Cerebellar Neoplasms / diagnosis. Hemangioblastoma / complications. Hemangioblastoma / diagnosis. Intracranial Hemorrhages / etiology

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  • [CommentIn] Surg Neurol. 2008 Jul;70(1):108-9 [18313731.001]
  • (PMID = 17350421.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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10. Oztürk S, Soyluk O, Görçin S, Alişir S, Güven D, Türkmen A, Sever MS: A rare post-transplant malignancy, cerebellar hemangioblastoma: a case report. J Nephrol; 2005 Nov-Dec;18(6):781-2
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  • [Title] A rare post-transplant malignancy, cerebellar hemangioblastoma: a case report.
  • Hemangioblastoma (HB) is especially prevalent in the cerebellum.
  • On cranial magnetic resonance imaging (MRI), a mass lesion in the right cerebellar hemisphere was observed, 3 x 3 x 3 cm in size, which was pushing against the fourth ventricle, and the right cerebellar peduncle.
  • The pathological diagnosis was cerebellar hemangioblastoma.
  • The patient was diagnosed with sporadic hemangioblastoma.
  • It is generally sporadic in nature and approximately 20% can be associated with von Hippel-Lindau (VHL) syndrome.
  • As in this case, MRI is preferred for the diagnosis.
  • CONCLUSION: When cerebellar symptoms occur or a cerebellar mass lesion is detected in an organ recipient, HB should be considered in the differential diagnosis.
  • [MeSH-major] Cerebellar Neoplasms / etiology. Hemangioblastoma / etiology. Kidney Transplantation / adverse effects

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  • (PMID = 16358240.001).
  • [ISSN] 1121-8428
  • [Journal-full-title] Journal of nephrology
  • [ISO-abbreviation] J. Nephrol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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11. D'Haene N, Salik D, Hanset M, Salmon I: [A case of von Hippel-Lindau disease diagnosed at the autopsy]. Rev Med Brux; 2010 Mar-Apr;31(2):122-6
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  • A diagnosis of cerebellar hemangioblastoma is made on MRI and neurosurgical excision was performed.
  • At the autopsy, the finding of a bilateral renal clear cell carcinoma in addition to the cerebellar hemangioblastoma allows for the diagnosis of von Hippel-Lindau disease.

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  • (PMID = 20677668.001).
  • [ISSN] 0035-3639
  • [Journal-full-title] Revue médicale de Bruxelles
  • [ISO-abbreviation] Rev Med Brux
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Belgium
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12. Bishop FS, Liu JK, Chin SS, Fults DW: Recurrent cerebellar hemangioblastoma with enhancing tumor in the cyst wall: case report. Neurosurgery; 2008 Jun;62(6):E1378-9; discussion E1379
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  • [Title] Recurrent cerebellar hemangioblastoma with enhancing tumor in the cyst wall: case report.
  • Resection of cerebellar hemangioblastomas involves tumor excision and drainage of associated cysts.
  • We present an unusual variant of a hemangioblastoma that showed pathological evidence of a tumor within the cyst wall that correlated with radiographic cyst wall enhancement in a patient with a recurrent hemangioblastoma.
  • CLINICAL PRESENTATION: A 38-year-old woman with von Hippel-Lindau disease presented with a recurrent cerebellar hemangioblastoma despite two previous operations during which the mural nodule was removed but the cyst wall was not.
  • Histopathological examination showed a capillary hemangioblastoma with tumor tissue inside the cyst wall.
  • CONCLUSION: This unusual case of a hemangioblastoma with cyst wall enhancement demonstrates a correlation between enhancement on magnetic resonance imaging and presence of neoplasia within the cyst wall, as well as the importance of considering complete resection of these areas, including the cyst wall, for the prevention of recurrence.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Hemangioblastoma / pathology. Neoplasm Recurrence, Local / pathology. von Hippel-Lindau Disease / pathology

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  • (PMID = 18824960.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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13. Rasmussen A, Nava-Salazar S, Yescas P, Alonso E, Revuelta R, Ortiz I, Canizales-Quinteros S, Tusié-Luna MT, López-López M: Von Hippel-Lindau disease germline mutations in Mexican patients with cerebellar hemangioblastoma. J Neurosurg; 2006 Mar;104(3):389-94
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  • [Title] Von Hippel-Lindau disease germline mutations in Mexican patients with cerebellar hemangioblastoma.
  • METHODS: Patients admitted between 2002 and 2004 to the Instituto Nacional de Neurología y Neurocirugía for hemangioblastoma were prospectively enrolled, together with their at-risk family members.
  • Seven of the families had definite clinical criteria of VHL disease, five had sporadic hemangioblastoma, and four had CNS hemangioblastoma combined with minor visceral signs.
  • Molecular genetic testing identified five germline mutations in six of the definite VHL families (sensitivity 85%), but none in the possible VHL and sporadic hemangioblastoma cases; four of these mutations had been previously described and one is a novel mutation present in two unrelated families.
  • CONCLUSIONS: Genetic testing for mutations in the VHL gene is crucial in patients with CNS hemangioblastoma.
  • [MeSH-major] Germ-Line Mutation. Hemangioblastoma / etiology. Hemangioblastoma / genetics. von Hippel-Lindau Disease / complications. von Hippel-Lindau Disease / genetics
  • [MeSH-minor] Adolescent. Adult. Cerebellar Neoplasms. Child. Child, Preschool. DNA Mutational Analysis. Female. Genetic Testing. Humans. Male. Mexico. Middle Aged. Pedigree. Prognosis

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  • (PMID = 16572651.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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14. Chowdhury FU, Scarsbrook AF: Indium-111 pentetreotide uptake within cerebellar hemangioblastoma in von Hippel-lindau syndrome. Clin Nucl Med; 2008 Apr;33(4):294-6
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  • [Title] Indium-111 pentetreotide uptake within cerebellar hemangioblastoma in von Hippel-lindau syndrome.
  • The patient had undergone surgical resection of a left adrenal pheochromocytoma and a large right cerebellar hemangioblastoma several years previously.
  • Although there was no evidence for recurrence of pheochromocytoma and no uptake within the pancreatic lesion, there was focal tracer accumulation within the left cerebellar hemisphere.
  • MR imaging of the brain confirmed the presence of recurrent hemangioblastoma in the left cerebellum.
  • [MeSH-major] Cerebellar Neoplasms / radionuclide imaging. Hemangioblastoma / radionuclide imaging. Somatostatin / analogs & derivatives. von Hippel-Lindau Disease / radionuclide imaging

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  • (PMID = 18356676.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 51110-01-1 / Somatostatin; G083B71P98 / pentetreotide
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15. Ertas G, Altundag MB, Ucer AR, Cankal F, Altundag K: Treatment of recurrent cerebellar hemangioblastoma with external radiotherapy in a patient with von Hippel-Lindau disease: a case report and review of the literature. J Neurooncol; 2005 Jul;73(3):273-5
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  • [Title] Treatment of recurrent cerebellar hemangioblastoma with external radiotherapy in a patient with von Hippel-Lindau disease: a case report and review of the literature.
  • Common manifestations of the disease are retinal, cerebellar and medullary hemangioblastomas; renal cysts and carcinomas; pancreatic cysts; pheochromocytoma; and papilllary cystadenoma of the epididym.
  • We report the case of a 40-year-old man with type I von Hippel-Lindau disease treated with external radiotherapy for recurrent cerebellar hemangioblastoma.
  • [MeSH-major] Cerebellar Neoplasms / radiotherapy. Hemangioblastoma / radiotherapy. Neoplasm Recurrence, Local / radiotherapy. von Hippel-Lindau Disease / complications

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  • (PMID = 15980980.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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16. Kaelin WG Jr: The von hippel-lindau tumor suppressor protein: an update. Methods Enzymol; 2007;435:371-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Inactivation of the von Hippel-Lindau (VHL) tumor suppressor has been linked to a variety of tumors, including clear cell renal carcinoma, retinal and cerebellar hemangioblastoma, and pheochromocytoma.


17. Toledo M, Pujadas F, Purroy F, Alvarez-Sabin J: [Polycythaemia as a ready factor of transitory global amnesia]. Neurologia; 2005 Jul-Aug;20(6):317-20

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Two patients, who had a previous diagnostic of polycythaemia suffered an episode of TGA, in addition in one of the two cases a cerebellar hemangioblastoma was found.

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  • (PMID = 16007516.001).
  • [ISSN] 0213-4853
  • [Journal-full-title] Neurología (Barcelona, Spain)
  • [ISO-abbreviation] Neurologia
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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18. Lallu S, Naran S, Palmer D, Bethwaite P: Cyst fluid cytology of cerebellar hemangioblastoma: a case report. Diagn Cytopathol; 2008 May;36(5):341-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cyst fluid cytology of cerebellar hemangioblastoma: a case report.
  • Hemangioblastoma, an uncommon central nervous system neoplasm, commonly located in the cerebellum and more rarely in the spinal cord.
  • In this report, we described the cytologic features of a cerebellar hemangioblastoma in a 53-year-old man, present in cystic fluid obtained at cranioctomy.
  • The radiologic impression, cytologic features, and location led us to suggest the possibility of hemangioblastoma.
  • Subsequent histopathological material revealed the characteristic features of hemangioblastoma.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Cyst Fluid / cytology. Hemangioblastoma / pathology

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  • (PMID = 18418856.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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19. Skalova A, Síma R, Bohus P, Curík R, Lukás J, Michal M: Endolymphatic sac tumor (aggressive papillary tumor of middle ear and temporal bone): report of two cases with analysis of the VHL gene. Pathol Res Pract; 2008;204(8):599-606
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • VHL gene mutations have been shown both in ELSTs associated with VHLD and in sporadic cases.
  • The second was a sporadic case, the patient having no symptoms of VHLD.
  • The tissues obtained from Heffner tumor and cerebellar hemangioblastoma from the patient with inherited VHLD possess a point mutation in exon 1 of VHL gene.
  • No mutation was found in any of the three exons analyzed and in the exon-intron junctions of the VHL gene in the sporadic case.

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  • (PMID = 18423895.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] EC 6.3.2.19 / VHL protein, human; EC 6.3.2.19 / Von Hippel-Lindau Tumor Suppressor Protein
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20. Hayashi S, Takeda N, Komura E: Symptomatic cerebellar hemorrhage from recurrent hemangioblastoma during delivery. Case report. Neurol Med Chir (Tokyo); 2010;50(12):1105-7
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  • [Title] Symptomatic cerebellar hemorrhage from recurrent hemangioblastoma during delivery. Case report.
  • A 30-year-old woman suffered cerebellar hemorrhage during the delivery of her first child.
  • She had undergone surgical removal of a symptomatic cerebellar hemangioblastoma 6 years previously.
  • Neuroradiological examinations indicated recurrent hemangioblastoma, confirmed by histological examination of the surgical specimen.
  • Women of reproductive age who have been treated for hemangioblastoma need careful long-term follow up, even if they show no signs of lesion recurrence.
  • [MeSH-major] Cerebellar Neoplasms / complications. Cerebellum / blood supply. Hemangioblastoma / complications. Intracranial Hemorrhages / etiology. Neoplasm Recurrence, Local / complications

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  • (PMID = 21206188.001).
  • [ISSN] 1349-8029
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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21. Stavrinos NG, Taylor R, Rowe A, Whittle IR: Posterior fossa surgery complicated by a pseudomeningocele, bilateral subdural hygromata and cerebellar cognitive affective syndrome. Br J Neurosurg; 2008 Feb;22(1):107-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Posterior fossa surgery complicated by a pseudomeningocele, bilateral subdural hygromata and cerebellar cognitive affective syndrome.
  • We report the case of a 51-year-old woman who underwent excision of a left postero-inferior, para-vermian cerebellar hemangioblastoma and foramen magnum decompression for an associated acquired Chiari I malformation.
  • Two weeks postoperatively she developed a pseudomeningocele, bilateral supra- and infratentorial subdural hygromata, and a clinical disorder compatible with the cerebellar cognitive affective syndrome.
  • The relationships between the subdural hygromas, pseudomeningocele, location of the lesion within the cerebellum, cerebellar oedema, and the cause of her cognitive-affective syndrome are discussed.
  • [MeSH-major] Cerebellar Neoplasms / surgery. Cognition Disorders / etiology. Communication Disorders / etiology. Hemangioblastoma / surgery. Infratentorial Neoplasms / surgery. Subdural Effusion / surgery

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  • (PMID = 18224531.001).
  • [ISSN] 0268-8697
  • [Journal-full-title] British journal of neurosurgery
  • [ISO-abbreviation] Br J Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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22. Joerger M, Koeberle D, Neumann HP, Gillessen S: Von Hippel-Lindau disease--a rare disease important to recognize. Onkologie; 2005 Mar;28(3):159-63
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Patients are at risk of developing cerebellar, spinal and retinal hemangioblastoma, renal cell carcinoma, pheochromocytoma, pancreatic neuroendocrine tumors, pancreatic and renal cysts, and epididymal cystadenoma.
  • The most common causes of death from VHL are metastases from renal cell carcinoma and neurological complications from cerebellar hemangioblastomas.
  • CASE REPORT: A 19-year-old woman was surgically treated for cerebellar hemangioblastoma in 1998 and for renal cell carcinoma of the right side in 2002.
  • Familial VHL was subsequently diagnosed as the patient's mother was found to be affected with bilateral polycystic kidney disease with chronic renal failure as well as hemangioblastoma of the retina and medulla oblongata.
  • CONCLUSION: The multitude of VHL-associated tumors and intra-familial variability in clinical expressivity render early diagnosis of VHL difficult.
  • [MeSH-major] Diagnostic Errors / prevention & control. Rare Diseases / diagnosis. von Hippel-Lindau Disease / diagnosis. von Hippel-Lindau Disease / therapy
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Practice Guidelines as Topic. Practice Patterns, Physicians'

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  • (PMID = 15772467.001).
  • [ISSN] 0378-584X
  • [Journal-full-title] Onkologie
  • [ISO-abbreviation] Onkologie
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 33
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23. Ozkurt H, Degirmenci H, Yenice G, Karatag O, Basak M: Huge pancreas helps diagnosis in von Hippel-Lindau disease. Indian J Gastroenterol; 2006 Mar-Apr;25(2):90-1
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Huge pancreas helps diagnosis in von Hippel-Lindau disease.
  • Additionally, extrapancreatic findings such as cerebellar hemangioblastoma (3 patients), retinal hemangioblastoma (2), renal cell carcinoma (3), renal adenoma (1), renal cysts (4), and splenic cyst (1) helped to reach the right diagnosis.
  • Pancreatic cysts detected on imaging may be a clue to the diagnosis of von Hippel-Lindau disease.
  • In all patients with multiple pancreatic cysts, this disease should be included in the differential diagnosis.
  • [MeSH-major] Pancreatic Cyst / diagnosis. von Hippel-Lindau Disease / diagnosis

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  • (PMID = 16763339.001).
  • [ISSN] 0254-8860
  • [Journal-full-title] Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology
  • [ISO-abbreviation] Indian J Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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24. Kim HR, Suh YL, Kim JW, Lee JI: Disseminated hemangioblastomatosis of the central nervous system without von Hippel-Lindau disease: a case report. J Korean Med Sci; 2009 Aug;24(4):755-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We report a very rare case of hemangioblastomatosis that developed after surgical removal of a solitary cerebellar hemangioblastoma (HB).
  • A 51-yr-old man presented with back pain 10 yr after undergoing surgery for cerebellar HB.
  • A surgical specimen obtained from a lesion in the cauda equina showed pathological findings identical to those of the cerebellar HB that had been resected 10 yr earlier.
  • External beam radiation therapy and radiosurgery were subsequently performed; however, the patient succumbed one year after receiving the diagnosis of hemangioblastomatosis.
  • [MeSH-major] Central Nervous System Neoplasms / diagnosis. Hemangioblastoma / diagnosis
  • [MeSH-minor] Cerebellar Neoplasms / pathology. Cerebellar Neoplasms / radiotherapy. Cerebellar Neoplasms / surgery. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Recurrence. von Hippel-Lindau Disease / genetics

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  • (PMID = 19654966.001).
  • [ISSN] 1598-6357
  • [Journal-full-title] Journal of Korean medical science
  • [ISO-abbreviation] J. Korean Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2719216
  • [Keywords] NOTNLM ; Central Nervous System / Hemangioblastoma / von Hippel-Lindau Disease
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25. Violaris K, Siozos T, Skoulios N, Sakellariou P: A case report of a family with 7 patients of the Von Hippel-Lindau disease. Surg Neurol; 2007 Dec;68(6):650-4; discussion 654
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: This study presents a family with hereditary cerebellar hemangioblastomas, as manifestations of the VHLD.
  • Six patients were operated for cerebellar hemangioblastomas.
  • There were 2 patients who developed renal and pancreatic cysts, 3 patients retinal hemangioblastoma, and 2 others epididymic cysts.
  • A spinal cord arteriovenous malformation appeared in 1 patient who also had medulla hemangioblastoma.
  • Another patient lost vision in the left eye due to a retinal hemangioblastoma.
  • CONCLUSIONS: Although rare, VHLD must always be part of the differential diagnosis of a patient with cerebellar hemangioblastoma.
  • Timely diagnosis of the syndrome is essential for manifestations such as renal carcinoma or retinal hemangioblastoma.
  • Surgical resection is the gold standard, with excellent results, for hemangioblastomas of the cerebellum.
  • [MeSH-major] Cerebellar Neoplasms / genetics. Cerebellar Neoplasms / pathology. Hemangioblastoma / genetics. Hemangioblastoma / pathology. von Hippel-Lindau Disease / genetics. von Hippel-Lindau Disease / pathology
  • [MeSH-minor] Adolescent. Adult. Cerebellum / pathology. Family Health. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Pedigree

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  • (PMID = 18053860.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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26. Donovan DJ, Iskandar JI, Citrone MJ, Royer MC: Successful removal of a cerebellar hemangioblastoma in a combat support hospital. Mil Med; 2006 Mar;171(3):211-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Successful removal of a cerebellar hemangioblastoma in a combat support hospital.
  • [MeSH-major] Cerebellar Neoplasms / surgery. Hemangioblastoma / surgery. Hospitals, Military. Hospitals, Packaged. Military Medicine. Military Personnel. Warfare

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  • (PMID = 16602518.001).
  • [ISSN] 0026-4075
  • [Journal-full-title] Military medicine
  • [ISO-abbreviation] Mil Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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27. Rohana AG, Norazmi MK, Norlaila M: A rare case of Von Hippel Lindau disease. Med J Malaysia; 2006 Jun;61(2):254-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • VHL is associated with multi-organ involvement of benign and malignant tumours characterized by the presence of retinal angiomas, hemangioblastomas of the cerebellum and spinal cord, renal cell carcinomas, pheochromocytomas and other cystic lesions in the kidneys, pancreas, and epididymis.
  • This case report describes a 37 years old Chinese gentleman who presented to our institution for further management of bilateral pheochromocytoma and retinal angioblastoma with problems of duodenal ulcer and anaemia.
  • With these features the criteria for the diagnosis of von Hippel Lindau disease was established.
  • [MeSH-major] von Hippel-Lindau Disease / diagnosis
  • [MeSH-minor] Adrenal Gland Neoplasms / diagnosis. Adrenalectomy. Adult. Diagnosis, Differential. Humans. Male. Pheochromocytoma / diagnosis. Tomography, X-Ray Computed

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  • (PMID = 16898326.001).
  • [ISSN] 0300-5283
  • [Journal-full-title] The Medical journal of Malaysia
  • [ISO-abbreviation] Med. J. Malaysia
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Malaysia
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28. Murai Y, Kobayashi S, Tateyama K, Teramoto A: Persistent primitive trigeminal artery aneurysm associated with cerebellar hemangioblastoma. Case report. Neurol Med Chir (Tokyo); 2006 Mar;46(3):143-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Persistent primitive trigeminal artery aneurysm associated with cerebellar hemangioblastoma. Case report.
  • A 72-year-old man presented with a cerebellar vermian tumor manifesting as headaches and vertigo.
  • Angiography disclosed a vascular tumor fed by the superior cerebellar artery and an aneurysm of a primitive trigeminal artery.
  • Association of a cerebral aneurysm with a hemangioblastoma has been reported previously in only five cases.
  • [MeSH-major] Cerebellar Neoplasms / complications. Hemangioblastoma / complications. Intracranial Aneurysm / etiology

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  • (PMID = 16565584.001).
  • [ISSN] 0470-8105
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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29. Kanno H, Yamamoto I, Nishikawa R, Matsutani M, Wakabayashi T, Yoshida J, Shitara N, Yamasaki I, Shuin T, Clinical VHL Research Group in Japan: Spinal cord hemangioblastomas in von Hippel-Lindau disease. Spinal Cord; 2009 Jun;47(6):447-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Forty-eight out of 66 patients with associated spinal cord hemangioblastoma among 142 VHL patients were retrospectively examined with respect to clinical features, accompanying lesions and outcome of surgical treatment.
  • RESULTS: Among these 48 patients, 46 of them (95.8%) also had a central nervous system (CNS) hemangioblastoma at another site: 42 (87.5%) with cerebellar hemangioblastoma and 11 (22.9%) with brain stem hemangioblastoma.
  • Twenty-three patients (47.9%) had more than one spinal cord hemangioblastoma.
  • CONCLUSION: Von Hippel-Lindau disease patients bearing spinal cord hemangioblastomas mostly had a CNS hemangioblastoma at another site.
  • In these patients, when the timing of treatment for spinal cord hemangioblastoma is determined, the probability of occurrence and treatment of other lesions should be considered.
  • [MeSH-major] Hemangioblastoma / etiology. Hemangioblastoma / surgery. Spinal Cord Neoplasms / etiology. Spinal Cord Neoplasms / surgery. von Hippel-Lindau Disease / complications

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  • (PMID = 19030009.001).
  • [ISSN] 1476-5624
  • [Journal-full-title] Spinal cord
  • [ISO-abbreviation] Spinal Cord
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Investigator] Ibayashi Y; Yamaki T; Numagami Y; Jokura E; Kayama Y; Yamada Y; Shiokawa Y; Yamashita J; Hasegawa M; Hatano H; Shinoda J; Sakai N; Taki W; Matsushima S; Murao K; Matsubara T; Takahashi JA; Matsumoto K; Nakajima H; Hashimoto M; Matsumoto S; Ichigizaki K; Murase I; Kashiwabara K; Yamakawa Y; Yamazaki H; Kubo S; Tokuda K; Abiko S; Miyazaki H; Anda T; Shibata S; Miyamoto T; Okawa N; Morimoto S; Inoue M; Miyagami M
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30. Ideguchi M, Kajiwara K, Yoshikawa K, Kato S, Ishihara H, Fujii M, Fujisawa H, Suzuki M: Continuous hypertension and tachycardia after resection of a hemangioblastoma behind the dorsal medulla oblongata: relationship to sympathetic overactivity at the neurogenic vasomotor center. J Neurosurg; 2010 Aug;113(2):369-73
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Continuous hypertension and tachycardia after resection of a hemangioblastoma behind the dorsal medulla oblongata: relationship to sympathetic overactivity at the neurogenic vasomotor center.
  • A very rare case of continuous hypertension and tachycardia after excision of a cerebellar hemangioblastoma at the dorsal medulla oblongata is presented.
  • [MeSH-major] Autonomic Nervous System Diseases / etiology. Brain Stem Neoplasms / surgery. Hemangioblastoma / surgery. Hypertension / etiology. Postoperative Complications / etiology. Tachycardia / etiology


31. Ishizawa K, Komori T, Hirose T: Stromal cells in hemangioblastoma: neuroectodermal differentiation and morphological similarities to ependymoma. Pathol Int; 2005 Jul;55(7):377-85
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Stromal cells in hemangioblastoma: neuroectodermal differentiation and morphological similarities to ependymoma.
  • The histogenesis of stromal cells in hemangioblastoma is inconclusive despite a long-term controversy.
  • An immunohistochemical and ultrastructural study was conducted for 17 cases of cerebellar hemangioblastoma.
  • In all cases, the microscopic hallmark characterizing hemangioblastomas, that is, lipid-containing stromal cells and a fine capillary network, known as a reticular variant, was noted.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Hemangioblastoma / pathology. Stromal Cells / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Antigens, CD / analysis. Antigens, CD56 / analysis. Antigens, CD57 / analysis. Cell Adhesion Molecules / analysis. Cell Differentiation. Child. Cytoskeletal Proteins. Diagnosis, Differential. Ependymoma / pathology. Female. Humans. Immunohistochemistry. Male. Microscopy, Electron. Middle Aged. Neuroectodermal Tumors / pathology. Phosphoproteins / analysis. Phosphopyruvate Hydratase / analysis. S100 Proteins / analysis. Vascular Endothelial Growth Factor A / analysis. Vascular Endothelial Growth Factor Receptor-2 / analysis. Vimentin / analysis

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  • (PMID = 15982211.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD56; 0 / Antigens, CD57; 0 / CD99 protein, human; 0 / Cell Adhesion Molecules; 0 / Cytoskeletal Proteins; 0 / Phosphoproteins; 0 / S100 Proteins; 0 / Vascular Endothelial Growth Factor A; 0 / Vimentin; 0 / ezrin; EC 2.7.10.1 / Vascular Endothelial Growth Factor Receptor-2; EC 4.2.1.11 / Phosphopyruvate Hydratase
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32. Muscarella LA, Barbano R, Augello B, Formica V, Micale L, Zelante L, D'Agruma L, Merla G: An 11-bp duplication in the promoter region of the VHL gene in a patient with cerebellar hemangioblastoma and renal oncocytoma. J Hum Genet; 2007;52(6):485-91
Nature Publishing Group. Nature Publishing Group (subscription/membership/fee required).

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An 11-bp duplication in the promoter region of the VHL gene in a patient with cerebellar hemangioblastoma and renal oncocytoma.
  • Germline mutations of VHL tumour suppressor gene cause the VHL disease, while somatic mutations have been associated with sporadic hemangioblastomas and clear-cell renal carcinomas.
  • Moreover, consistent with the "two hits" model, microsatellite analysis of hemangioblastoma tissue from this patient revealed Allelic Imbalance for the chromosomal region near the VHL gene.
  • [MeSH-major] Adenoma, Oxyphilic / genetics. Cerebellar Neoplasms / genetics. Hemangioblastoma / genetics. Kidney Neoplasms / genetics. Promoter Regions, Genetic. Von Hippel-Lindau Tumor Suppressor Protein / genetics. von Hippel-Lindau Disease / genetics


33. Kiliçkesmez O: Endolymphatic sac tumor in a patient with von Hippel-Lindau disease: MR imaging findings. Diagn Interv Radiol; 2006 Mar;12(1):14-6
MedlinePlus Health Information. consumer health - Von Hippel-Lindau Disease.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A 29-year-old male patient with von Hippel-Lindau disease who had an operation for cerebellar hemangioblastoma six years ago is presented.
  • [MeSH-major] Ear Neoplasms / diagnosis. Magnetic Resonance Imaging / methods. von Hippel-Lindau Disease / diagnosis

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  • (PMID = 16538578.001).
  • [ISSN] 1305-3825
  • [Journal-full-title] Diagnostic and interventional radiology (Ankara, Turkey)
  • [ISO-abbreviation] Diagn Interv Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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34. Kato M, Ohe N, Okumura A, Shinoda J, Nomura A, Shuin T, Sakai N: Hemangioblastomatosis of the central nervous system without von Hippel-Lindau disease: a case report. J Neurooncol; 2005 May;72(3):267-70
Hazardous Substances Data Bank. GADOLINIUM, ELEMENTAL .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A 50-year-old woman had a history of surgical procedures for total removal of a cerebellar hemangioblastoma (HB).
  • Magnetic resonance imaging (MRI) showed multiple Gd-enhancing tumors around the brain stem, in the cerebellum, and in the cervical and thoracolumbar regions of the spine.
  • She underwent surgical removal of the tumors in the cerebellum and spinal cord.
  • [MeSH-major] Central Nervous System Neoplasms / pathology. Hemangioblastoma / pathology. von Hippel-Lindau Disease / pathology
  • [MeSH-minor] Cerebellar Neoplasms / pathology. Cerebellar Neoplasms / surgery. Female. Gadolinium. Humans. Hydrocephalus / etiology. Hydrocephalus / surgery. Magnetic Resonance Imaging. Middle Aged. Neoplasm Recurrence, Local. Quadriplegia / etiology. Spinal Cord Neoplasms / surgery. Tomography, X-Ray Computed. Ventriculoperitoneal Shunt

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  • (PMID = 15937651.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] AU0V1LM3JT / Gadolinium
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35. Jung SM, Kuo TT: Immunoreactivity of CD10 and inhibin alpha in differentiating hemangioblastoma of central nervous system from metastatic clear cell renal cell carcinoma. Mod Pathol; 2005 Jun;18(6):788-94
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunoreactivity of CD10 and inhibin alpha in differentiating hemangioblastoma of central nervous system from metastatic clear cell renal cell carcinoma.
  • The differential diagnosis between hemangioblastoma of the central nervous system and metastatic clear cell renal cell carcinoma can be problematic, because they may share striking morphologic similarities.
  • Since CD10 is expressed in clear cell renal cell carcinoma, while inhibin alpha is expressed in hemangioblastoma, we used CD10 and inhibin alpha (inhibin A) to study their possible use in the distinction of these two entities.
  • A total of 22 cases of cerebellar hemangioblastoma, five cases of metastatic clear cell renal cell carcinoma to the central nervous system, and 16 primary cases of clear cell renal cell carcinoma were studied with immunohistochemical staining of both CD10 and inhibin A.
  • All 22 cases of hemangioblastoma were immunonegative for CD10 in the stromal cells.
  • In all, 20 cases of hemangioblastoma (20/22, 91%) expressed inhibin A in the stromal cells.
  • In conclusion, in addition to the immunostaining of inhibin A, CD10 is a superior marker for distinguishing between a hemangioblastoma and a metastatic clear cell renal cell carcinoma.
  • [MeSH-major] Adenocarcinoma, Clear Cell / pathology. Biomarkers, Tumor / analysis. Carcinoma, Renal Cell / pathology. Central Nervous System Neoplasms / pathology. Hemangioblastoma / pathology. Kidney Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Inhibins / analysis. Male. Middle Aged. Neoplasm Metastasis. Neprilysin / analysis


36. Nakamura Y, Kanemura Y, Yamada T, Sugita Y, Higaki K, Yamamoto M, Takahashi M, Yamasaki M: D2-40 antibody immunoreactivity in developing human brain, brain tumors and cultured neural cells. Mod Pathol; 2006 Jul;19(7):974-85
MedlinePlus Health Information. consumer health - Childhood Brain Tumors.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • It has been used as a marker for lymphatic endothelium as well as mesothelioma and cerebellar hemangioblastoma.
  • In the developing cerebellum, positive D2-40 immunoreactivity was found in the external granular layer particularly of the outer portion and the Purkinje cell layer as well as meninges.
  • Therefore, D2-40 antibody is considered a useful marker for research on developing brain and diagnosis of brain tumors, differentiation between choroid plexus carcinoma and metastatic carcinoma.
  • [MeSH-major] Antibodies, Monoclonal. Antigens, Neoplasm / analysis. Brain Neoplasms / immunology. Cerebellum / immunology. Telencephalon / immunology

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  • (PMID = 16648867.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antigens, Neoplasm; 0 / monoclonal antibody D2-40; 0 / oncofetal antigens
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37. Rao PV, Lu X, Pattee P, Turner M, Nandgaonkar S, Paturi BT, Roberts CT Jr, Nagalla SR: Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus. J Assoc Physicians India; 2005 Jun;53:521-6
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The 20 genes with at least a 3-fold change, annotated with known phenotypic associations in the current gene databank (phenotype association, fold change) were aspartoacylase (Canavan disease, 9.96), growth hormone receptor (Laron dwarfism, idiopathic short stature, 8.25), lipoprotein lipase (familial chylomicronemia syndrome, lipoprotein lipase deficiency, 8.00), vitamin D (1,25- dihydroxyvitamin D3) receptor (involutional osteoporosis, vitamin D resistant rickets, 7.94), intercellular adhesion molecule 1 human rhinovirus receptor (cerebral malaria susceptibility, 7.16), peroxisomal membrane protein 3 35-kDa (Refsum disease, infantile form, Zellweger syndrome-3, 6.00), Bardet-Biedl syndrome 2 (Bardet-Biedl syndrome, 5.87), ribosomal protein S19 (Diamond Blackfan anemia, 5.85), apolipoprotein C-III (hypertriglyceridemia, 5.44), argininosuccinate lyase (argininosuccinicaciduria, 5.22), myosin VA (Griscelli syndrome-type pigmentary dilution with mental retardation, 4.92), lysozyme (renal amyloidosis, 4.17), SAM domain, SH3 domain and nuclear localisation signals 1 (Cherubism, 4.12 ), von Hippel-Lindau syndrome (hemangioblastoma, cerebellar, somatic, von Hippel-Lindau syndrome, 3.94), early-onset breast cancer 1 (BRCA1, papillary serous carcinoma of the peritoneum, 3.73), UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase (inclusion body myopathy, autosomal recessive, sialuria, 3.53), apolipoprotein A-I (amyloidosis, 3 or more types, hypoalphalipoproteinemia, 3.29), midline 1 Opitz/BBB syndrome (Opitz G syndrome, type I, 3.28), ATPase, Na+/K+ transporting, alpha 2 (+) polypeptide (familial hemiplegic migraine, 3.05).


38. Akcaglar S, Yavascaoglu I, Vuruskan H, Oktay B: Genetic evaluation of von Hippel-Lindau disease for early diagnosis and improved prognosis. Int Urol Nephrol; 2008;40(3):615-20
MedlinePlus Health Information. consumer health - Von Hippel-Lindau Disease.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Genetic evaluation of von Hippel-Lindau disease for early diagnosis and improved prognosis.
  • Detailed clinical examination of the 22 kindreds with a VHL mutation revealed cerebellar hemangioblastoma (three kindreds), meningioma (two) and renal cell carcinoma (five).

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  • (PMID = 18074239.001).
  • [ISSN] 0301-1623
  • [Journal-full-title] International urology and nephrology
  • [ISO-abbreviation] Int Urol Nephrol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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39. Alexiou GA, Tsiouris S, Polyzoidis KS, Fotopoulos AD, Kyritsis AP: Re: Delayed diagnosis of cerebellar hemangioblastoma after intracerebellar hemorrhage (Lee et al Surg Neurol 2007;67:419-421) Technetium (99m)Tc tetrofosmin brain single-photon emission computed tomography in the evaluation of posterior fossa lesions. Surg Neurol; 2008 Jul;70(1):108-9
Genetic Alliance. consumer health - Hemangioblastoma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Re: Delayed diagnosis of cerebellar hemangioblastoma after intracerebellar hemorrhage (Lee et al Surg Neurol 2007;67:419-421) Technetium (99m)Tc tetrofosmin brain single-photon emission computed tomography in the evaluation of posterior fossa lesions.
  • [MeSH-major] Cerebellar Neoplasms / radionuclide imaging. Hemangioblastoma / radionuclide imaging. Intracranial Hemorrhages / etiology. Organophosphorus Compounds. Organotechnetium Compounds. Radiopharmaceuticals. Tomography, Emission-Computed, Single-Photon

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  • [CommentOn] Surg Neurol. 2007 Apr;67(4):419-21 [17350421.001]
  • (PMID = 18313731.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Organophosphorus Compounds; 0 / Organotechnetium Compounds; 0 / Radiopharmaceuticals; 0 / technetium Tc 99m 1,2-bis(bis(2-ethoxyethyl)phosphino)ethane
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40. Dimogerontas G, Konstantinidis E, Antoniadis I: Gustatory disturbance due to a cerebellar hemangioblastoma. Br J Neurosurg; 2008 Feb;22(1):110-2
Genetic Alliance. consumer health - Hemangioblastoma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gustatory disturbance due to a cerebellar hemangioblastoma.
  • [MeSH-major] Cerebellar Neoplasms / complications. Dysgeusia / etiology. Hemangioblastoma / surgery

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  • (PMID = 17852106.001).
  • [ISSN] 0268-8697
  • [Journal-full-title] British journal of neurosurgery
  • [ISO-abbreviation] Br J Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 3
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41. Patier de La Peña JL, Norman F, Rodríguez-Ramírez GI, Echániz-Quintana A, Moreno-Cobo MA: [Cervical pain, torticollis and polyglobulia as a first manifestation of a cerebellar hemangioblastoma]. Rev Clin Esp; 2010 Jun;210(6):e21-3
MedlinePlus Health Information. consumer health - Brain Tumors.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Cervical pain, torticollis and polyglobulia as a first manifestation of a cerebellar hemangioblastoma].
  • [Transliterated title] Cervicalgia, tortícolis y poliglobulia como forma de presentación de un hemangioblastoma cerebeloso.
  • [MeSH-major] Brain Neoplasms / diagnosis. Hemangioblastoma / diagnosis

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  • (PMID = 20434723.001).
  • [ISSN] 1578-1860
  • [Journal-full-title] Revista clínica española
  • [ISO-abbreviation] Rev Clin Esp
  • [Language] spa
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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