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1. Mardi K, Sharma J: Testicular retiform Sertoli cell tumor: a problem in histopathologic diagnosis. Indian J Pathol Microbiol; 2008 Jan-Mar;51(1):70-1
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  • [Title] Testicular retiform Sertoli cell tumor: a problem in histopathologic diagnosis.
  • A 9-year-old boy who presented with a left scrotal swelling was subsequently diagnosed as retiform sertoli cell tumor of testis which consisted entirely of retiform pattern.
  • [MeSH-major] Sertoli Cell Tumor / diagnosis. Testicular Neoplasms / pathology
  • [MeSH-minor] Child. Diagnosis, Differential. Humans. Male

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  • (PMID = 18417863.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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2. Ersoy O: Very high alpha-fetoprotein in a young man due to concomitant presentation of hepatocellular carcinoma and Sertoli cell testis tumor. World J Gastroenterol; 2005 Nov 28;11(44):7051-3
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  • [Title] Very high alpha-fetoprotein in a young man due to concomitant presentation of hepatocellular carcinoma and Sertoli cell testis tumor.
  • Studies reported that there is a close relationship between hepatocellular carcinoma (HCC) and testis carcinoma.
  • Both tumors can be presented as synchronal tumors, or as testicular metastases of HCC or as hepatic metastases of testicular tumor( [7] ).
  • Like HCC, germ cell tumors of the testis also release AFP; but it is shown that some of Sertoli cell tumors of testis can also release AFP( [10] ).
  • Herein we have reported about the first case of HCC in the literature which is presented concomitantly with Sertoli-Leydig tumor of testis, leading to extremely high level of AFP in a 21-year-old man.
  • [MeSH-major] Liver Neoplasms. Sertoli Cell Tumor. Testicular Neoplasms. alpha-Fetoproteins / metabolism
  • [MeSH-minor] Adult. Biomarkers, Tumor / blood. Carcinoma, Hepatocellular / blood. Carcinoma, Hepatocellular / diagnosis. Carcinoma, Hepatocellular / pathology. Comorbidity. Humans. Male. Neoplasms, Multiple Primary

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  • (PMID = 16437617.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / alpha-Fetoproteins
  • [Other-IDs] NLM/ PMC4717055
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3. Chang H, Guillou F, Taketo MM, Behringer RR: Overactive beta-catenin signaling causes testicular sertoli cell tumor development in the mouse. Biol Reprod; 2009 Nov;81(5):842-9
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  • [Title] Overactive beta-catenin signaling causes testicular sertoli cell tumor development in the mouse.
  • Mice with mutations that result in overactive WNT/beta-catenin signaling developed tumors in some tissues, such as digestive tract, skin, and ovary, but they failed to develop tumors in other tissues, such as mammary gland, liver, kidney, and primordial germ cells.
  • To investigate whether overactive beta-catenin signaling is capable of inducing Sertoli cell tumorigenesis in testes, we generated Ctnnb1(tm1Mmt/+);Tg(AMH-cre)1Flor male mice that express a constitutively active form of beta-catenin specifically in Sertoli cells.
  • No tumors were observed at 4 mo of age, but 70% of the mutant males developed Sertoli cell tumors at 8 mo of age.
  • At 1 yr of age, more than 90% of the mutant males developed tumors.
  • No instances of extratesticular spread of the tumors were found in the mutant mice.
  • These studies show a causal link between overactive WNT/beta-catenin signaling and Sertoli cell tumor development and provide a novel mouse model for the study of Sertoli cell tumor biology.

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  • [ErratumIn] Biol Reprod. 2010 Apr;82(4):803
  • (PMID = 19553598.001).
  • [ISSN] 1529-7268
  • [Journal-full-title] Biology of reproduction
  • [ISO-abbreviation] Biol. Reprod.
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / HD30284; United States / NCI NIH HHS / CA / P30 CA016672; United States / NCI NIH HHS / CA / CA16672; United States / NICHD NIH HHS / HD / R37 HD030284; United States / NICHD NIH HHS / HD / R01 HD030284
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / beta Catenin
  • [Other-IDs] NLM/ PMC2770017
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4. Lefevre H, Bouvattier C, Lahlou N, Adamsbaum C, Bougnères P, Carel JC: Prepubertal gynecomastia in Peutz-Jeghers syndrome: incomplete penetrance in a familial case and management with an aromatase inhibitor. Eur J Endocrinol; 2006 Feb;154(2):221-7
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  • BACKGROUND: Peutz-Jeghers syndrome (PJS) is a rare autosomal-dominant disorder characterized by multiple gastrointestinal hamartomatous polyps, mucocutaneous pigmentation and increased predisposition to various neoplasms.
  • Endocrine manifestations in PJS include gynecomastia due to calcified Sertoli cell testicular tumors usually referred to as large-cell calcifying Sertoli cell tumors (LSCT).
  • MAIN OUTCOME MEASURES: Longitudinal measurements of sex-steroids, gonadotropins, Sertoli cell markers and auxological evaluation.
  • RESULTS: The two male siblings with PJS had similar bilateral multifocal testicular calcifications and biochemical evidence of Sertoli cell dysfunction manifested by elevated plasma inhibin-alpha levels.
  • During treatment with anastrozole, estradiol levels, growth and skeletal maturation, as well as Sertoli cell markers (inhibin B, inhibin-alpha and anti-Mullerian hormone) decreased.
  • Moreover, the decrease in Sertoli cell markers during aromatase inhibitor treatment suggests that increased estrogen production is a primary event regulating downstream production of Sertoli cell peptides.

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  • (PMID = 16452534.001).
  • [ISSN] 0804-4643
  • [Journal-full-title] European journal of endocrinology
  • [ISO-abbreviation] Eur. J. Endocrinol.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Aromatase Inhibitors; 0 / Glycoproteins; 0 / Nitriles; 0 / Testicular Hormones; 0 / Triazoles; 0 / inhibin B; 0 / inhibin-alpha subunit; 2Z07MYW1AZ / anastrozole; 57285-09-3 / Inhibins; 80497-65-0 / Anti-Mullerian Hormone; 9007-49-2 / DNA
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5. Golombos D, Brison D, Sadeghi-Nejad H: Malignant sertoli cell tumor of the testis with a large retroperitoneal mass in an elderly man. Urol J; 2010;7(4):281-3
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  • [Title] Malignant sertoli cell tumor of the testis with a large retroperitoneal mass in an elderly man.
  • [MeSH-major] Lymph Nodes / radiography. Retroperitoneal Neoplasms / radiography. Sertoli Cell Tumor / pathology. Testicular Neoplasms / pathology

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  • (PMID = 21170861.001).
  • [ISSN] 1735-546X
  • [Journal-full-title] Urology journal
  • [ISO-abbreviation] Urol J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Iran
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6. Miller MA, Hartnett SE, Ramos-Vara JA: Interstitial cell tumor and Sertoli cell tumor in the testis of a cat. Vet Pathol; 2007 May;44(3):394-7
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  • [Title] Interstitial cell tumor and Sertoli cell tumor in the testis of a cat.
  • Testicular tumors are rarely reported in cats.
  • We describe a case of interstitial cell tumor and Sertoli cell tumor in a cat that developed aggressive behavior and inappropriate urination 7 years after it was obtained from a shelter as an allegedly castrated 2 year old.
  • Testes were not palpable, but the left testis was found in the scrotum by surgical exploration and was mostly replaced by the 2 tumors.
  • The interstitial cell tumor, but not the Sertoli cell tumor, was immunohistochemically positive for Melan-A, consistent with steroid production.
  • Behavior improved after excision of the testis and penile papillae began to regress, but the cat was euthanatized 3 1/2 months after castration at the owner's request.
  • Neither tumor had metastasized.
  • The right testis was never found and was presumed to have been removed during the reported castration procedure.
  • [MeSH-major] Cat Diseases / pathology. Leydig Cell Tumor / veterinary. Sertoli Cell Tumor / veterinary

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  • (PMID = 17491086.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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7. Hummel M, Schaaf L, Füchtenbusch M, Standl E, Ziegler A: [62 year-old patient with rapid progressive edema, low potassium and hypertension]. Internist (Berl); 2006 Apr;47(4):427, 429-33
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  • Primary neoplasm is a small cell cancer.
  • A Sertoli-cell-tumor of the testis was diagnosed as an additional carcinoma.
  • [MeSH-major] Cushing Syndrome / etiology. Edema / etiology. Hypertension / etiology. Hypokalemia / etiology. Sertoli Cell Tumor / complications. Testicular Neoplasms / complications. Testicular Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Disease Progression. Humans. Male. Middle Aged


8. Jayasena SN, Ariyasinghe JT, Gunawardena DM, Gunawardena SA, de Silva MV: Large-cell calcifying sertoli cell tumour of the testis detected at screening of a family with Carney syndrome. Urol Int; 2005;75(4):365-7
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  • [Title] Large-cell calcifying sertoli cell tumour of the testis detected at screening of a family with Carney syndrome.
  • We report the detection of a large-cell calcifying Sertoli cell tumour (LCCSCT) in a 34-year-old male during screening of a family with Carney syndrome.
  • The patient had ignored the testicular swelling for 7 years.
  • [MeSH-major] Calcinosis / pathology. Neoplasms, Multiple Primary / diagnosis. Sertoli Cell Tumor / pathology. Testicular Neoplasms / pathology

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  • (PMID = 16327308.001).
  • [ISSN] 0042-1138
  • [Journal-full-title] Urologia internationalis
  • [ISO-abbreviation] Urol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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9. Abbas F, Bashir NW, Hussainy AS: Sclerosing Sertoli cell tumor of the testis. J Coll Physicians Surg Pak; 2005 Jul;15(7):437-8
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  • [Title] Sclerosing Sertoli cell tumor of the testis.
  • Sclerosing Sertoli-cell tumor is a rare, sex-cord-stromal tumor of the testis with distinct clinical and pathological features with only 14 such cases reported in contemporary literature.
  • We report such a tumor in a young diabetic and hypertensive male.
  • Pathological examination of right radical orchidectomy specimen was consistent with sclerosing sub-type of Sertoli-cell testicular tumor with no invasion.
  • [MeSH-major] Sertoli Cell Tumor / pathology. Testicular Neoplasms / pathology
  • [MeSH-minor] Adult. Comorbidity. Diabetes Mellitus / epidemiology. Humans. Hypertension / epidemiology. Male. Sertoli Cells / pathology

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  • (PMID = 16197877.001).
  • [ISSN] 1022-386X
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Pakistan
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10. Talon I, Moog R, Kauffmann I, Grandadam S, Becmeur F: Sertoli cell tumor of the testis in children: reevaluation of a rarely encountered tumor. J Pediatr Hematol Oncol; 2005 Sep;27(9):491-4
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  • [Title] Sertoli cell tumor of the testis in children: reevaluation of a rarely encountered tumor.
  • Testis tumors are uncommon in childhood, and they differ from adult tumors in terms of histology and frequency.
  • Sertoli cell tumors appear in children before 1 year of age.
  • In the authors' hospital, of 13 testis tumors diagnosed since 1996, only 2 were Sertoli cell tumors.
  • It would be helpful to have an algorithm for the management of testis tumors, outlining how to make the diagnosis of malignancy and which treatment and follow-up to pursue.
  • [MeSH-major] Algorithms. Sertoli Cell Tumor / pathology. Testicular Neoplasms / pathology
  • [MeSH-minor] Age Factors. Child, Preschool. Humans. Infant. Male. Neoplasm Staging. Orchiectomy

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  • (PMID = 16189443.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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11. Azurmendi Arín I, Llarena Ibarguren R, Rodríguez JG, Olano Grasa I, Cantón Aller E, Pertusa Peña C: [Sertoli cell malignant tumor]. Arch Esp Urol; 2008 Sep;61(7):834-7
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  • [Title] [Sertoli cell malignant tumor].
  • [Transliterated title] Tumor de células de Sertoli maligno.
  • OBJECTIVE: We report a new case of Sertoli cell testicular tumor with malignant characteristics.
  • METHODS: 77 year-old male patient, suffering a general wasting syndrome presenting with a left solid testicular mass with the diagnosis of malignant Sertoli cell tumor after orchyectomy, without local, regional or distant dissemination, and a benign outcome after 18 months of follow-up.
  • RESULTS: Sertoli cell tumor or androblastoma is classified as non-germ cell tumor derived from the stroma of the sexual cords.
  • There are three types depending on its cellular composition: calcified big cell, sclerotic cell, and the most frequent of all, the classic type.
  • CONCLUSIONS: Being the Sertoli cell testicular tumor rare, its malignant type is even rarer, accounting for not more than 10% of all.
  • [MeSH-major] Sertoli Cell Tumor. Testicular Neoplasms

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  • (PMID = 18972923.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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12. Calcagno C: Sclerosing Sertoli cell tumor of the testis. Urologia; 2007 Jan-Mar;74(1):37-9

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  • [Title] Sclerosing Sertoli cell tumor of the testis.
  • Sclerosing Sertoli cell tumor of the testis is a very rare neoplasm.

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  • (PMID = 21086416.001).
  • [ISSN] 0391-5603
  • [Journal-full-title] Urologia
  • [ISO-abbreviation] Urologia
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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13. Denayer E, Devriendt K, de Ravel T, Van Buggenhout G, Smeets E, Francois I, Sznajer Y, Craen M, Leventopoulos G, Mutesa L, Vandecasseye W, Massa G, Kayserili H, Sciot R, Fryns JP, Legius E: Tumor spectrum in children with Noonan syndrome and SOS1 or RAF1 mutations. Genes Chromosomes Cancer; 2010 Mar;49(3):242-52
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  • [Title] Tumor spectrum in children with Noonan syndrome and SOS1 or RAF1 mutations.
  • Noonan syndrome (NS) is an autosomal dominant disorder caused by mutations in PTPN11, KRAS, SOS1, and RAF1.
  • Three patients with SOS1 mutations presented with tumors (embryonal rhabdomyosarcoma, Sertoli cell testis tumor, and granular cell tumors of the skin).
  • One patient with a RAF1 mutation had a lesion suggestive for a giant cell tumor.
  • This is the first report describing different tumor types in NS patients with germ line SOS1 mutations.


14. Gómez García I, Romero Molina M, López-García Moreno A, Buendía González E, Rubio Hidalgo E, Bolufer E, Sampietro Crespo A, Gómez Rodríguez A: Sertoli cell tumor, a rare testicular tumor, our experience and review of the literature. Arch Esp Urol; 2010 Jun;63(5):392-5
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  • [Title] Sertoli cell tumor, a rare testicular tumor, our experience and review of the literature.
  • OBJECTIVE: We report two new cases of Sertoli cell testicular tumors, and a Cochrane and Medline search of cases published worldwide.
  • METHODS: We reviewed our series of testicular tumors, the stromal tumor incidence, clinical presentation, treatment and prognosis, and the experience reflected in the literature.
  • RESULTS: The prevalence of testicular tumors in our health area is of 0.09%, and 2.3% of them are Sertoli cell neoplasms.
  • This figure is slightly higher than the found in other series in which Sertoli tumors range from 0.4% to 1.5% of testicular malignancies in adults and reach 4% in children.
  • CONCLUSIONS: Sertoli cell tumor has an incidence not exceeding 4%.
  • [MeSH-major] Sertoli Cell Tumor. Testicular Neoplasms

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  • (PMID = 20587845.001).
  • [ISSN] 1576-8260
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] eng; spa
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Spain
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15. Gopinath D, Draffan D, Philbey AW, Bell R: Use of intralesional oestradiol concentration to identify a functional pulmonary metastasis of canine sertoli cell tumour. J Small Anim Pract; 2009 Apr;50(4):198-200
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  • [Title] Use of intralesional oestradiol concentration to identify a functional pulmonary metastasis of canine sertoli cell tumour.
  • A seven-year-old, 31 kg male neutered Labrador was investigated for signs of feminisation syndrome and prostatic disease four years after castration and removal of a testicular sertoli cell tumour (SCT).
  • [MeSH-major] Dog Diseases / diagnosis. Estradiol / analysis. Lung Neoplasms / veterinary. Sertoli Cell Tumor / veterinary. Testicular Neoplasms / veterinary

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  • (PMID = 19037884.001).
  • [ISSN] 0022-4510
  • [Journal-full-title] The Journal of small animal practice
  • [ISO-abbreviation] J Small Anim Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 4TI98Z838E / Estradiol
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16. Adayener C, Akyol I, Sen B, Ates F, Haholu A, Soydan H, Karagoz B: Sertoli cell tumor of the testis: a case with late metastasis. Int Urol Nephrol; 2008;40(4):1005-8
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  • [Title] Sertoli cell tumor of the testis: a case with late metastasis.
  • We report on a 20-year-old male who underwent a radical orchidectomy when he was 12 years old which revealed a Sertoli cell tumor in his right testis, and who presented with a 5 x 3 cm retroperitoneal metastatic mass 8 years after orchidectomy.
  • Current experience on Sertoli cell tumor of the testis (SCTT) is insufficient to prognosticate the clinical behavior of the primary tumor on the long term.
  • [MeSH-major] Retroperitoneal Neoplasms / secondary. Sertoli Cell Tumor / pathology. Testicular Neoplasms / pathology

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  • (PMID = 18500567.001).
  • [ISSN] 0301-1623
  • [Journal-full-title] International urology and nephrology
  • [ISO-abbreviation] Int Urol Nephrol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Hungary
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17. Sato K, Ueda Y, Sakurai A, Ishikawa Y, Okamoto SY, Ikawa H, Katsuda S: Large cell calcifying Sertoli cell tumor of the testis: comparative immunohistochemical study with Leydig cell tumor. Pathol Int; 2005 Jun;55(6):366-71
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  • [Title] Large cell calcifying Sertoli cell tumor of the testis: comparative immunohistochemical study with Leydig cell tumor.
  • Large cell calcifying Sertoli cell tumor is a rare type of testicular tumor.
  • Reported herein is a Japanese patient with this tumor not associated with Carney's complex.
  • An 11-year-old boy was admitted to hospital because of left testicular enlargement, and radical orchiectomy was performed.
  • Macroscopically, the tumor was well circumscribed and had a maximum diameter of approximately 2 cm.
  • Histologically, the tumor was composed of large neoplastic cells with abundant eosinophilic cytoplasm with a tubular, trabecular, and solid arrangement and loose myxoid stroma with irregularly shaped calcification.
  • Immunohistochemically, the tumor cells were positive for vimentin, S-100 protein, calretinin, inhibin-alpha, melan-A, and CD10, and type IV collagen and laminin were observed in the extracellular matrix around the tumor cells.
  • The distributions of melan-A, CD10, and mitochondria were characteristically patchy; in contrast, they were diffusely distributed in the cytoplasm in a control case of Leydig cell tumor.
  • The differences in immunostaining patterns for melan-A, CD10, and mitochondria as well as positivity for S-100 protein-beta might be useful diagnostic hallmarks of large cell calcifying Sertoli cell tumor for discrimination from Leydig cell tumor.
  • [MeSH-major] Calcinosis / pathology. Sertoli Cell Tumor / pathology. Testicular Neoplasms / pathology
  • [MeSH-minor] Antigens, Neoplasm. Calbindin 2. Child. Collagen Type V / analysis. Diagnosis, Differential. Humans. Immunohistochemistry. Inhibins / analysis. MART-1 Antigen. Male. Microscopy, Electron. Neoplasm Proteins / analysis. Neprilysin / analysis. S100 Calcium Binding Protein G / analysis. S100 Proteins / analysis. Testis / chemistry. Testis / pathology. Testis / ultrastructure. Vimentin / analysis

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  • (PMID = 15943795.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / CALB2 protein, human; 0 / Calbindin 2; 0 / Collagen Type V; 0 / MART-1 Antigen; 0 / MLANA protein, human; 0 / Neoplasm Proteins; 0 / S100 Calcium Binding Protein G; 0 / S100 Proteins; 0 / Vimentin; 0 / inhibin-alpha subunit; 57285-09-3 / Inhibins; EC 3.4.24.11 / Neprilysin
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18. Devouassoux-Shisheboran M, Deschildre C, Mauduit C, Berger G, Mejean-Lebreton F, Bouvier R, Droz JP, Fénichel P, Benahmed M: Expression of galectin-3 in gonads and gonadal sex cord stromal and germ cell tumors. Oncol Rep; 2006 Aug;16(2):335-40
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  • [Title] Expression of galectin-3 in gonads and gonadal sex cord stromal and germ cell tumors.
  • Galectin-3, a beta-galactoside-binding lectin, has been implicated in many human malignancies, but has seldom been studied in human gonads and gonadal tumors.
  • The aim of our study was to investigate galectin-3 mRNA and protein expression in normal ovaries and testes as well as in a variety of 51 gonadal sex cord stromal and germ cell tumors, and two testicular seminomatous and non-seminomatous cell lines, using either real-time PCR or immunohistochemistry.
  • In human testes, galectin-3 is specifically expressed in mature Sertoli cells and Leydig cells, and is absent from fetal and pre-pubertal testes, suggesting a hormone-dependence of this gene.
  • In human ovaries, galectin-3 is absent from granulosa cells, as well as from granulosa cell and Sertoli-Leydig cell tumors, and is not a useful marker in distinguishing granulosa cell from Sertoli-Leydig cell tumors.
  • In testicular tumorigenesis, galectin-3 has a dual function according to the histological type of tumors and their hormone dependency.
  • In malignant testicular Sertoli cell tumors, the expression of galectin-3 is down-regulated while, in benign Leydig cell tumors, this expression is maintained, indicating the possible implication of this gene in the development of more aggressive testicular sex cord stromal tumors.
  • In contrast to sex cord stromal tumors, galectin-3 expression is up-regulated in testicular germ cell tumors.
  • By real-time PCR, we demonstrated a significant elevation of the galectin-3 mRNA level in non-seminomatous testicular germ cell tumors and cell line as compared to normal testes and seminomas (p=0.0432 and p=0.0247, respectively), indicating the possible role of this gene in the non-seminomatous differentiation of germ cell tumors.
  • [MeSH-major] Biomarkers, Tumor / analysis. Galectin 3 / analysis. Sertoli Cell Tumor / diagnosis. Sex Cord-Gonadal Stromal Tumors / diagnosis. Testicular Neoplasms / diagnosis
  • [MeSH-minor] Female. Humans. Immunohistochemistry. Male. Ovarian Neoplasms / chemistry. Ovarian Neoplasms / diagnosis. Ovary / chemistry. RNA, Messenger / analysis. Receptors, Androgen / analysis. Reverse Transcriptase Polymerase Chain Reaction. Sertoli Cells / chemistry. Testis / chemistry

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  • (PMID = 16820912.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Galectin 3; 0 / RNA, Messenger; 0 / Receptors, Androgen
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19. Leach S, Heatley JJ, Pool RR Jr, Spaulding K: Bilateral testicular germ cell-sex cord-stromal tumor in a pekin duck (Anas platyrhynchos domesticus). J Avian Med Surg; 2008 Dec;22(4):315-9
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  • [Title] Bilateral testicular germ cell-sex cord-stromal tumor in a pekin duck (Anas platyrhynchos domesticus).
  • Histopathologic examination of the large masses revealed a collision pattern testicular tumor consisting of Sertoli, seminoma, and interstitial cell components.
  • The hepatic nodule was a metastatic lesion consistent with a Sertoli cell testicular tumor.
  • This is the first reported case of a mixed germ cell-sex cord-stromal tumor in a duck.
  • [MeSH-major] Ducks. Poultry Diseases / pathology. Sertoli Cell Tumor / veterinary. Sex Cord-Gonadal Stromal Tumors / veterinary. Testicular Neoplasms / veterinary
  • [MeSH-minor] Animals. Fatal Outcome. Liver Neoplasms / secondary. Liver Neoplasms / veterinary. Male. Seminoma / diagnosis. Seminoma / pathology. Seminoma / veterinary

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  • (PMID = 19216259.001).
  • [ISSN] 1082-6742
  • [Journal-full-title] Journal of avian medicine and surgery
  • [ISO-abbreviation] J. Avian Med. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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20. Werther M, Schmelz HU, Schwerer M, Sparwasser C: [Sclerosing Sertoli cell tumor of the testis: a rare tumor. Case report and review of the literature on the subtypes of Sertoli-cell tumor]. Urologe A; 2007 Nov;46(11):1551-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Sclerosing Sertoli cell tumor of the testis: a rare tumor. Case report and review of the literature on the subtypes of Sertoli-cell tumor].
  • [Transliterated title] Sklerosierender Sertoli-Zell-Tumor des Hodens - ein seltener Tumor : Fallvorstellung und Literaturübersicht über die Subtypen des Sertoli-Zell-Tumors.
  • Sertoli cell tumors of the testis are extremely rare (0.4-1.5% of all testicular neoplasms) and have a heterogeneous pathology.
  • Histopathologically classic, large cell calcifying and sclerosing subtypes are differentiated.Up to now, 14 cases of sclerosing Sertoli cell tumor are known.
  • While no cases of sclerosing Sertoli cell tumor with a malignant course have been reported, both other subtypes have been found to be potentially malignant.
  • In the case of malignancy the prognosis is very poor, and it is difficult to select the best treatment because there is so little experience with this type of tumor.
  • Once the diagnosis of a Sertoli cell tumor has been confirmed, exact determination of the histological subtype is essential to allow appropriate risk-adapted therapy.
  • [MeSH-major] Sertoli Cell Tumor / diagnosis. Testicular Neoplasms / diagnosis
  • [MeSH-minor] Adult. Biomarkers, Tumor / blood. Biopsy. Diagnosis, Differential. Fatty Liver, Alcoholic / blood. Humans. Male. Neoplasm Staging. Sclerosis. Testis / pathology. Ultrasonography. alpha-Fetoproteins

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  • (PMID = 17898983.001).
  • [ISSN] 0340-2592
  • [Journal-full-title] Der Urologe. Ausg. A
  • [ISO-abbreviation] Urologe A
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / alpha-Fetoproteins
  • [Number-of-references] 20
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21. Jiménez JD, Cebrián JL, Guarch R, Hualde A: [Sertoli cell tumor of the testis with positive neuroendocrine markers]. Actas Urol Esp; 2010 May;34(5):481-3
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  • [Title] [Sertoli cell tumor of the testis with positive neuroendocrine markers].
  • [Transliterated title] Tumor testicular de células de Sertoli con marcadores neuroendocrinos positivos.
  • [MeSH-major] Sertoli Cell Tumor / pathology. Testicular Neoplasms / pathology

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  • (PMID = 20470725.001).
  • [ISSN] 1699-7980
  • [Journal-full-title] Actas urologicas españolas
  • [ISO-abbreviation] Actas Urol Esp
  • [Language] spa
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Synaptophysin
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22. Shin SL, Outwater EK: Benign large cell calcifying Sertoli cell tumor of the testis in a prepubescent patient. AJR Am J Roentgenol; 2007 Aug;189(2):W65-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Benign large cell calcifying Sertoli cell tumor of the testis in a prepubescent patient.
  • [MeSH-major] Sertoli Cell Tumor / radiography. Sertoli Cell Tumor / ultrasonography. Testicular Neoplasms / radiography. Testicular Neoplasms / ultrasonography
  • [MeSH-minor] Adolescent. Diagnosis, Differential. Humans. Male. Tomography, X-Ray Computed

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  • (PMID = 17646440.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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23. Charoniti I, Kavazarakis E, Kontaxaki C, Bonou-Boukouvalea I, Fretzayas A, Stassinopoulou A: Large cell calcifying Sertoli cell tumor of the testis in a boy with brucellosis. Pediatr Int; 2006 Oct;48(5):501-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Large cell calcifying Sertoli cell tumor of the testis in a boy with brucellosis.
  • [MeSH-major] Brucellosis / complications. Calcinosis / complications. Sertoli Cell Tumor / complications. Testicular Neoplasms / complications

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  • (PMID = 16970792.001).
  • [ISSN] 1328-8067
  • [Journal-full-title] Pediatrics international : official journal of the Japan Pediatric Society
  • [ISO-abbreviation] Pediatr Int
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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24. Halat SK, Ponsky LE, MacLennan GT: Large cell calcifying Sertoli cell tumor of testis. J Urol; 2007 Jun;177(6):2338
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Large cell calcifying Sertoli cell tumor of testis.
  • [MeSH-major] Calcinosis / pathology. Sertoli Cell Tumor / pathology. Testicular Neoplasms / pathology

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  • (PMID = 17509353.001).
  • [ISSN] 0022-5347
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 3
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25. Al-Maghrabi JA: Large cell calcifying Sertoli cell tumor of the testis. Ann Saudi Med; 2005 Sep-Oct;25(5):436-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Large cell calcifying Sertoli cell tumor of the testis.
  • [MeSH-major] Carcinoma, Large Cell / pathology. Sertoli Cell Tumor / pathology. Testicular Neoplasms / pathology. Testis / pathology

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  • (PMID = 16270775.001).
  • [ISSN] 0256-4947
  • [Journal-full-title] Annals of Saudi medicine
  • [ISO-abbreviation] Ann Saudi Med
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Saudi Arabia
  • [Chemical-registry-number] 0 / Chorionic Gonadotropin, beta Subunit, Human; 9002-67-9 / Luteinizing Hormone; 9002-68-0 / Follicle Stimulating Hormone
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26. Zhang JW, Gou XM, Li Z, Peng TS: [Clinicopathologic features of large-cell calcifying Sertoli cell tumor of the testis]. Zhonghua Bing Li Xue Za Zhi; 2007 Apr;36(4):281-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinicopathologic features of large-cell calcifying Sertoli cell tumor of the testis].
  • [MeSH-major] Calcinosis / pathology. Sertoli Cell Tumor / pathology. Testicular Neoplasms / pathology. Testis / pathology

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  • (PMID = 17706128.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / S100 Proteins; 0 / Vimentin; 0 / inhibin-alpha subunit; 57285-09-3 / Inhibins
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27. Sato K, Tachibana H, Morinaga S, Ueda Y, Katsuda S: Sertoli cell tumor of the testis, not otherwise specified, presenting extensive hemorrhage and overexpression of alpha-methylacyl-CoA racemase (AMACR/P504S). Virchows Arch; 2007 Mar;450(3):361-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sertoli cell tumor of the testis, not otherwise specified, presenting extensive hemorrhage and overexpression of alpha-methylacyl-CoA racemase (AMACR/P504S).
  • [MeSH-major] Hemorrhage / pathology. Racemases and Epimerases / metabolism. Sertoli Cell Tumor / pathology. Testicular Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Humans. Male. Middle Aged. Orchiectomy. Testis / pathology. Testis / surgery. Testis / ultrasonography. Ultrasonography

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  • (PMID = 17252229.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 5.1.- / Racemases and Epimerases; EC 5.1.99.4 / alpha-methylacyl-CoA racemase
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