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1. Chu M, Wei LL, Li GZ, Lin YZ, Zhao SG: Bilateral acoustic neurinomas presenting as subarachnoid hemorrhage: case report. Chin Med J (Engl); 2007 Jan 5;120(1):83-4
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  • [Title] Bilateral acoustic neurinomas presenting as subarachnoid hemorrhage: case report.

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  • (PMID = 17254495.001).
  • [ISSN] 0366-6999
  • [Journal-full-title] Chinese medical journal
  • [ISO-abbreviation] Chin. Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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2. Hasegawa M, Fujisawa H, Hayashi Y, Tachibana O, Kida S, Yamashita J: Surgical pathology of spinal schwannoma: has the nerve of its origin been preserved or already degenerated during tumor growth? Clin Neuropathol; 2005 Jan-Feb;24(1):19-25
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  • [Title] Surgical pathology of spinal schwannoma: has the nerve of its origin been preserved or already degenerated during tumor growth?
  • OBJECTIVE: This study was aimed to understand ultrastructural pathology of nerves of tumor origin of spinal schwannomas, which has not been reported so far, in order to understand the mechanism of the postoperative functional restoration after the nerve transection.
  • METHODS: From 13 patients who underwent sacrifice of an affected nerve root at total removal of spinal schwannomas (C2 conus), the proximal (spinal cord side, n = 12) and distal (dorsal root ganglion side, n = 10) stumps of the nerves of the tumor origin were collected and examined by light and electron microscope, followed by morphometric analysis (n = 9).
  • CONCLUSIONS: This data combined with no permanent deficits after nerve transection suggest that the nerves of tumor origin are in the processes of slowly progressed deterioration with repeated degeneration and regeneration/remyelination, and the postoperative rapid recovery from the transient neurological deficit may be explained by functional compensation by the adjacent non-affected nerves with slow tumor growth.
  • [MeSH-major] Nerve Degeneration. Neurilemmoma / pathology. Peripheral Nervous System Neoplasms / pathology. Spinal Nerve Roots / pathology. Spinal Nerve Roots / physiopathology

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  • (PMID = 15696780.001).
  • [ISSN] 0722-5091
  • [Journal-full-title] Clinical neuropathology
  • [ISO-abbreviation] Clin. Neuropathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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3. Kulkarni N, Andrews SJ, Rao V, Rajagopal KV: Case report: Benign porta hepatic schwannoma. Indian J Radiol Imaging; 2009 Jul-Sep;19(3):213-5
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  • [Title] Case report: Benign porta hepatic schwannoma.
  • Schwannoma is a myelin sheath tumor that can occur almost anywhere in the body.
  • Benign schwannomas in the porta hepatis are extremely rare and radiologically are diagnosed as either enlarged lymph nodes or bowel masses, such as gastrointestinal stromal tumors.

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  • (PMID = 19881089.001).
  • [ISSN] 1998-3808
  • [Journal-full-title] The Indian journal of radiology & imaging
  • [ISO-abbreviation] Indian J Radiol Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2766878
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4. Gal TJ, Shinn J, Huang B: Current epidemiology and management trends in acoustic neuroma. Otolaryngol Head Neck Surg; 2010 May;142(5):677-81
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  • OBJECTIVE: The objective of this study was to assess the epidemiology of acoustic neuroma and determine current trends in therapy using tumor registry techniques.
  • SUBJECTS AND METHODS: The Surveillance Epidemiology and End Results (SEER) database is a national tumor registry that began to identify and abstract benign and borderline tumors of the brain and central nervous system in the year 2004.
  • Coding for International Classification of Diseases for Oncology (ICD-O-3) codes for schwannoma (9560/0) with collaborative staging (CS) coding for acoustic nerve (72.4) was used to identify acoustic neuromas.
  • Demographic data, tumor size, and treatment data were analyzed.
  • Tumors were equally distributed across gender and tumor laterality, with the majority (84%) occurring in Caucasians.


5. Ogino J, Asanuma H, Sakurai S, Matsuno Y, Miyokawa N, Yamashiro K, Fukazawa Y, Muraoka S, Iwaki Y, Kondo N, Hasegawa T: Use of tissue microarrays and immunohistochemistry to standardize the diagnosis of gastrointestinal stromal tumors. Pathol Int; 2010 Nov;60(11):707-13
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  • We assessed the concordance among seven general pathologists with respect to histologic diagnosis and interpretation of c-kit proto-oncogene (KIT) and platelet-derived growth factor receptor alpha (PDGFRA) immunostaining of 36 cases of primary spindle-cell tumor, predominantly of the gastrointestinal tract, mesentery, and retroperitoneum, based on review of a tissue microarray (TMA) subjected to immunohistochemistry with antibodies to KIT/CD117, PDGFRA, vimentin, desmin, smooth muscle action, CD34, and S-100 protein.
  • Tumors included 20 molecularly analyzed gastrointestinal stromal tumors (GISTs), 4 leiomyosarcomas, 4 schwannomas, 4 desmoid-type fibromatoses, and 4 solitary fibrous tumors.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Gastrointestinal Stromal Tumors / diagnosis. Sarcoma / diagnosis

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  • [Copyright] © 2010 The Authors. Pathology International © 2010 Japanese Society of Pathology and Blackwell Publishing Asia Pty Ltd.
  • (PMID = 20946519.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Desmin; 0 / S100 Proteins; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor alpha; EC 2.7.10.1 / Receptors, Platelet-Derived Growth Factor
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6. Koerbel A, Gharabaghi A, Samii A, Gerganov V, von Gösseln H, Tatagiba M, Samii M: Trigeminocardiac reflex during skull base surgery: mechanism and management. Acta Neurochir (Wien); 2005 Jul;147(7):727-32; discussion 732-3
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  • FINDINGS: Sixteen patients (8%) had a TCR intra-operatively (7 vestibular schwannomas, 5 sphenoid wing meningiomas, 3 petroclival meningiomas, 1 intracavernous epidermoid cyst).

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  • (PMID = 15889318.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Austria
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7. Chien HP, Chang YS, Hsu PS, Lin JD, Wu YC, Chang HL, Chuang CK, Tsuei KH, Hsueh C: Adrenal cystic lesions: a clinicopathological analysis of 25 cases with proposed histogenesis and review of the literature. Endocr Pathol; 2008;19(4):274-81
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  • Seven adrenal pseudocysts were associated with tumor, including two pheochromocytomas, one neuroblastoma, one adrenal cortical carcinoma, one adrenal cortical adenoma, one myelolipoma, and one schwannoma.

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  • (PMID = 18972224.001).
  • [ISSN] 1046-3976
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 25
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8. Pons Y, Ukkola-Pons E, Conessa C: [Vestibular schwannoma]. Rev Prat; 2009 Nov 20;59(9):1206
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Vestibular schwannoma].
  • [Transliterated title] Neurinome de l'acoustique.

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  • (PMID = 19961070.001).
  • [ISSN] 0035-2640
  • [Journal-full-title] La Revue du praticien
  • [ISO-abbreviation] Rev Prat
  • [Language] fre
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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9. Eisinger FS: Case of the month. Schwannoma. JAAPA; 2007 Oct;20(10):72
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  • [Title] Case of the month. Schwannoma.
  • [MeSH-major] Neurilemmoma / diagnosis. Spinal Cord Compression / etiology

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  • (PMID = 18019331.001).
  • [ISSN] 1547-1896
  • [Journal-full-title] JAAPA : official journal of the American Academy of Physician Assistants
  • [ISO-abbreviation] JAAPA
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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10. Gao Z, Palleschi SM, Chen S: Plexiform epithelioid schwannoma: a case report. Am J Dermatopathol; 2007 Feb;29(1):56-8
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  • [Title] Plexiform epithelioid schwannoma: a case report.
  • Epithelioid schwannoma is rare but may pose a challenge in histopathologic diagnosis.
  • In the present report, we describe a plexiform variant of epithelioid schwannoma in the skin of the breast of a 47-year-old woman.
  • [MeSH-major] Epithelioid Cells / pathology. Neurilemmoma / pathology. Skin Neoplasms / pathology

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  • (PMID = 17284962.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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11. Hung CH, Tsai TH, Lieu AS, Lin CL, Lee KS, Hwang SL, Howng SL: Giant invasive schwannoma of cauda equina with minimal neurologic deficit: a case report and literature review. Kaohsiung J Med Sci; 2008 Apr;24(4):212-7
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  • [Title] Giant invasive schwannoma of cauda equina with minimal neurologic deficit: a case report and literature review.
  • Giant invasive cauda equina schwannoma was diagnosed according to the criteria of Sridhar et al.
  • Schwannomas are usually benign and common tumors arising from nerve sheath cells, particularly from sensory nerves.
  • Giant invasive schwannomas, however, are rare, and most of patients with them present with severe neurologic deficits independent of daily activity, although in the case presented here, in spite of the large size of the tumor causing pedicle erosion, expansive destruction of the vertebral body and widening of the neural foramina, there were only minimal neurologic deficits.
  • We have therefore decided to report this case, with a review of the relevant English literature emphasizing clinical presentations, plain film images and magnetic resonance image findings of giant invasive cauda equina schwannoma for early diagnosis and differential diagnosis.
  • [MeSH-major] Cauda Equina. Neurilemmoma / diagnosis. Spinal Cord Neoplasms / diagnosis

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  • (PMID = 18424359.001).
  • [ISSN] 1607-551X
  • [Journal-full-title] The Kaohsiung journal of medical sciences
  • [ISO-abbreviation] Kaohsiung J. Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] China (Republic : 1949- )
  • [Number-of-references] 13
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12. Trufant JW, Brenn T, Fletcher CD, Virata AR, Cook DL, Bosenberg MW: Melanotic schwannoma arising in association with nevus of Ota: 2 cases suggesting a shared mechanism. Am J Dermatopathol; 2009 Dec;31(8):808-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Melanotic schwannoma arising in association with nevus of Ota: 2 cases suggesting a shared mechanism.
  • Melanotic schwannoma is a rare markedly pigmented peripheral nerve sheath tumor comprising cells with prominent melanization and schwannian features.
  • The psammomatous variety is associated with Carney complex, a multiple neoplasia syndrome with spotty skin pigmentation.
  • We present the first 2 reported cases of melanotic schwannoma arising in patients with a history of nevus of Ota, a rare dermal melanosis believed to represent a failure of melanocyte migration to the epidermis during embryogenesis.
  • Morphological, immunohistochemical, and ultrastructural features support a diagnosis of melanotic schwannoma.
  • Melanotic schwannoma is most often benign but has been associated with malignant behavior in some cases.
  • Distinguishing this nerve sheath tumor from malignant melanoma can be difficult but is of great clinical importance due to differences in prognosis and treatment.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Neurilemmoma / pathology. Nevus of Ota / pathology. Skin Neoplasms / pathology


13. Sachdeva R, Rothner DA, Traboulsi EI, Hayden BC, Rychwalski PJ: Astrocytic hamartoma of the optic disc and multiple café-au-lait macules in a child with neurofibromatosis type 2. Ophthalmic Genet; 2010 Dec;31(4):209-14
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The characteristic and diagnostic finding of NF2 is bilateral vestibular nerve schwannomas (acoustic neuromas).


14. Alekseeva NS, Krotenkova MV, Konovalov RN, Kirichenko IM, Baev AA, Petrova EI: [The role of neurovisualization methods in diagnosis and verification of vertigo etiology]. Vestn Otorinolaringol; 2006;(1):18-23
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RCT and MRI verify cochleovestibular syndromes in patients with multiple encephalomyelitis, VIII nerve neurinoma and tumors of the posterior cranial fossa.

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  • (PMID = 16482004.001).
  • [ISSN] 0042-4668
  • [Journal-full-title] Vestnik otorinolaringologii
  • [ISO-abbreviation] Vestn. Otorinolaringol.
  • [Language] rus
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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15. Thompson L: Temporal bone schwannoma. Ear Nose Throat J; 2006 Nov;85(11):704
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  • [Title] Temporal bone schwannoma.
  • [MeSH-major] Neurilemmoma / pathology. Skull Neoplasms / pathology. Temporal Bone

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  • (PMID = 17168142.001).
  • [ISSN] 0145-5613
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 2
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16. Sade B, Mohr G, Dufour JJ: Vascular complications of vestibular schwannoma surgery: a comparison of the suboccipital retrosigmoid and translabyrinthine approaches. J Neurosurg; 2006 Aug;105(2):200-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Vascular complications of vestibular schwannoma surgery: a comparison of the suboccipital retrosigmoid and translabyrinthine approaches.
  • OBJECT: Vascular complications of the surgery for vestibular schwannomas (VSs) can have devastating consequences; however, there is scant literature on the systematic analysis of the different types of complications.
  • METHODS: The charts of 391 patients who had undergone 413 procedures for VS during a 24-year period were reviewed retrospectively.


17. Ryu CH, Kim SW, Lee KH, Lee JY, Kim H, Lee WK, Choi BH, Lim Y, Kim YH, Lee KH, Hwang TK, Jun TY, Rha HK: The merlin tumor suppressor interacts with Ral guanine nucleotide dissociation stimulator and inhibits its activity. Oncogene; 2005 Aug 11;24(34):5355-64
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The merlin tumor suppressor interacts with Ral guanine nucleotide dissociation stimulator and inhibits its activity.
  • Neurofibromatosis type 2 (NF2) is the most commonly mutated gene in benign tumors of the human nervous system such as schwannomas and meningiomas.
  • The NF2 gene encodes a protein called schwannomin or merlin, which is involved in regulating cell growth and proliferation through protein-protein interactions with various cellular proteins.
  • Functional studies showed that merlin inhibits the RalGDS-induced RalA activation, the colony formation and the cell migration in mammalian cells.
  • These results suggest that merlin can function as a tumor suppressor by inhibiting the RalGDS-mediated oncogenic signals.
  • [MeSH-minor] Animals. COS Cells. Cell Movement. Cell Transformation, Neoplastic. Cercopithecus aethiops. Colony-Forming Units Assay. Humans. Immunohistochemistry. Mice. NIH 3T3 Cells. Protein Binding. Two-Hybrid System Techniques. Yeasts

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  • (PMID = 16007223.001).
  • [ISSN] 0950-9232
  • [Journal-full-title] Oncogene
  • [ISO-abbreviation] Oncogene
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Neurofibromin 2; 0 / ral Guanine Nucleotide Exchange Factor
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18. Scheller C, Rampp S, Rachinger JC, Prell J, Koesling S, Becker S, Strauss C: Contrast enhancement and histopathological findings in vestibular schwannoma. Cent Eur Neurosurg; 2010 Feb;71(1):35-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Contrast enhancement and histopathological findings in vestibular schwannoma.
  • Changes of contrast uptake are considered to indicate the efficacy of therapy in irradiated vestibular schwannomas.
  • We present a case of a large vestibular schwannoma with heterogeneous contrast uptake on MRI.
  • Using neuronavigation, histological samples were obtained during surgery from an area with homogeneous contrast uptake and from a central tumor portion without contrast enhancement on MRI.
  • Intraoperative investigation found no evidence of necrotic tumor, and histopathological examination revealed an active tumor in both sections, with no central necrosis.
  • This finding illustrates the surgical experience that " necrotic tumor areas " on MRI may not be consistent with intraoperative findings.
  • Lack of contrast uptake in previously irradiated schwannomas may not be indicative of effective radiotherapy.

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  • (PMID = 20201125.001).
  • [ISSN] 1868-4912
  • [Journal-full-title] Central European neurosurgery
  • [ISO-abbreviation] Cent Eur Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media
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19. Anton T, Guttierez J, Rock J: Tentorial schwannoma: a case report and review of the literature. J Neurooncol; 2006 Feb;76(3):307-11
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  • [Title] Tentorial schwannoma: a case report and review of the literature.
  • INTRODUCTION: Schwannomas are most often found in association with the eighth cranial nerve, but may also arise from any other cranial nerve.
  • Unusual locations for intracranial schwannomas have also been reported in association with neurofibromatosis.
  • CLINICAL PRESENTATION: A 23-year-old male without von Recklinghausen's disease presented with intermittent dizziness and difficulty swallowing.
  • Magnetic resonance imaging revealed a large tentorial-based tumor.
  • At surgery the origin of the tumor was clearly the tentorium, and while the trigeminal nerve was displaced, it easily separated from the mass.
  • Pathological review was consistent with schwannoma.
  • CONCLUSION: While there are few reported cases of tentorial-based schwannoma, these tumors have been noted in unusual locations within the intracranial vault, and clinicians should be aware of this diversity of origin.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Dura Mater / pathology. Neurilemmoma / pathology

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  • (PMID = 16200344.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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20. Sahu RN, Mehrotra N, Tyagi I, Banerji D, Jain VK, Behari S: Management strategies for bilateral vestibular schwannomas. J Clin Neurosci; 2007 Aug;14(8):715-22
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  • [Title] Management strategies for bilateral vestibular schwannomas.
  • BACKGROUND: Bilateral vestibular schwannomas (VS) are rare.
  • AIMS: To highlight the differences in clinical presentations and surgical results of bilateral VS compared to unilateral VS; and, to propose a management strategy for these tumors with reference to tumor size, extent of growth and the presence or absence of hearing impairment.
  • Assessment of VIIth and VIIIth cranial nerve function, tumor size, volume and extent of growth was performed in all patients.
  • The management strategy was based on Samii's classification of tumor extent.
  • Giant tumors were present in seven (43.7%) patients; large tumors in eight (50%) and a medium-sized tumor in one (6.3%).
  • Total tumor resection was achieved in 13 patients and subtotal resection in two.
  • On the contralateral side, one large tumor required total excision.
  • One medium sized tumor underwent sub-capsular excision in an attempt to preserve hearing.
  • CONCLUSIONS: Patients with bilateral schwannomas are younger, have larger lesions, poorer preoperative hearing and are more likely to lose either auditory and/or facial nerve function during attempted total resection of the tumor.

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  • (PMID = 17577524.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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21. Hemminki K, Tretli S, Sundquist J, Johannesen TB, Granström C: Familial risks in nervous-system tumours: a histology-specific analysis from Sweden and Norway. Lancet Oncol; 2009 May;10(5):481-8
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  • BACKGROUND: There are limited data available on tumour subtype-specific familial risks for nervous-system tumours.
  • METHODS: We used data from the nationwide Swedish and Norwegian databases on familial cancer to calculate standardised incidence ratios (SIRs) for the familial risk of developing a nervous-system tumour in offspring born after 1931 (Sweden) or 1900 (Norway) whose parents or siblings were probands.
  • Of 709 familial patients in the offspring generation, 438 (61.8%) had a parent affected by a nervous-system tumour (SIR 1.66; 95% CI 1.51-1.82), 236 (33.3%) had a sibling affected by a nervous-system tumour (SIR 2.01; 95% CI 1.76-2.28), and 35 (4.9%) belonged to families with a parent and at least two siblings affected by a nervous-system tumour (multiplex families; SIR 13.40; 95% CI 9.33-18.66).
  • Early-onset neurinoma and haemangioma showed high familial risks; with an SIR for neurinoma of 1.7 (1.4-2.2) for offspring of affected parents, 2.7 (2.0-3.5) for siblings, and 27.2 (13.5-48.8) for multiplex families, and an SIR for haemangioma of 2.4 (1.4-3.8) for offspring of affected parents.
  • INTERPRETATION: Our results suggest a complex genetic background for nervous-system tumours, which differs depending on the age of onset and histological subtype of the tumour.
  • [MeSH-major] Genetic Predisposition to Disease. Nervous System Neoplasms / genetics

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  • [CommentIn] Lancet Oncol. 2009 May;10(5):439-40 [19410189.001]
  • (PMID = 19356978.001).
  • [ISSN] 1474-5488
  • [Journal-full-title] The Lancet. Oncology
  • [ISO-abbreviation] Lancet Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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22. Shah RK, Blevins NH, Karmody CS: Mid-frequency sensorineural hearing loss: aetiology and prognosis. J Laryngol Otol; 2005 Jul;119(7):529-33
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  • OBJECTIVES: An audiometric finding of mid-frequency sensorineural hearing loss (MFSNHL), or a U-shaped pattern, is uncommon.
  • DESIGN: Tertiary academic referral centre-based retrospective case review and review of audiograms to determine the prevalence of this audiometric finding.
  • The notes were reviewed for any pertinent otologic history, subsequent diagnoses, management and disease course.
  • Of all patients, 22 had hereditary hearing loss, eight had idiopathic hearing loss, and five adults had vestibular schwannomas.
  • CONCLUSIONS: MFSNHL is an infrequent audiometric finding.
  • The great majority of these cases are of presumed hereditary or idiopathic aetiology, although 22 per cent of adults had vestibular schwannomas.


23. Alicandri-Ciufelli M, Marchioni D, Mattioli F, Trani M, Presutti L: Critical literature review on the management of intraparotid facial nerve schwannoma and proposed decision-making algorithm. Eur Arch Otorhinolaryngol; 2009 Apr;266(4):475-9
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  • [Title] Critical literature review on the management of intraparotid facial nerve schwannoma and proposed decision-making algorithm.
  • Management of intraparotid facial nerve schwannomas (IFNS) is very challenging because the diagnosis is often made intra-operatively and in most cases, resection could lead to severe facial nerve (FN) paralysis, with important aesthetic consequences.
  • Articles in the English language focused on the management of FN schwannoma have been selected and critically reviewed.
  • In the case of type A or B neoplasms, or in case of a pre-operative FN House-Brackmann (HB) grade IV or worse, the authors would favor a resection of the IFNS and (where necessary) a reconstruction of the nerve.
  • In the case of pre-operative HB grade III or better and type C or D neoplasms, patients would undergo an intra-operative biopsy to rule out malignancy, and a possible conservative management could be adopted.
  • [MeSH-major] Cranial Nerve Neoplasms / therapy. Decision Support Techniques. Facial Nerve. Facial Nerve Diseases / therapy. Neurilemmoma / therapy. Parotid Neoplasms / therapy

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  • [Cites] Am J Otolaryngol. 2008 Mar-Apr;29(2):126-9 [18314025.001]
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  • (PMID = 19096863.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 17
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24. Mysorekar VV, Rao SG, Jalihal U, Sridhar M: Schwannoma of the ascending colon. Indian J Pathol Microbiol; 2010 Jan-Mar;53(1):198-200
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  • [Title] Schwannoma of the ascending colon.
  • [MeSH-major] Colon, Ascending / pathology. Colonic Neoplasms / diagnosis. Colonic Neoplasms / pathology. Neurilemmoma / diagnosis. Neurilemmoma / pathology

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  • (PMID = 20090280.001).
  • [ISSN] 0974-5130
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] India
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25. Lin EP, Marshall J, Bhatt S, Simon R, Davis R, Dogra VS: Penile schwannoma: sonographic features. J Ultrasound Med; 2006 Nov;25(11):1447-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Penile schwannoma: sonographic features.
  • [MeSH-major] Neurilemmoma / ultrasonography. Penile Neoplasms / ultrasonography

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  • (PMID = 17060432.001).
  • [ISSN] 0278-4297
  • [Journal-full-title] Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
  • [ISO-abbreviation] J Ultrasound Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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26. Tredway TL, Santiago P, Hrubes MR, Song JK, Christie SD, Fessler RG: Minimally invasive resection of intradural-extramedullary spinal neoplasms. Neurosurgery; 2006 Feb;58(1 Suppl):ONS52-8; discussion ONS52-8
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  • Traditional laminectomy for tumor resection disrupts the muscular, ligamentous, and bony structures of the spine, which may contribute to pain and instability.
  • Histologically, five tumors were determined to be schwannomas and one was identified as a myxopapillary ependymoma.
  • Potential reduction in blood loss, hospitalization and disruption to local tissues suggest that, in the hands of an experienced surgeon, this technique may present an alternative to traditional open tumor resection.

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  • [CommentIn] Neurosurgery. 2006 Nov;59(5):E1152 [17143217.001]
  • (PMID = 16479629.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article
  • [Publication-country] United States
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27. Lee HK, Seo IA, Seo E, Seo SY, Lee HJ, Park HT: Netrin-1 induces proliferation of Schwann cells through Unc5b receptor. Biochem Biophys Res Commun; 2007 Nov 3;362(4):1057-62
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  • [Title] Netrin-1 induces proliferation of Schwann cells through Unc5b receptor.
  • However, accumulating evidence implies that they may also participate in the cell survival and apoptosis.
  • Here, we show that netrin-1 induces proliferation of Schwann cells.
  • Unc5b is the sole receptor expressed in RT4 schwannoma cells and adult primary Schwann cells, and netrin-1 and Unc5b are found to be expressed in the injured sciatic nerve.
  • It was also found that the netrin-1-induced Schwann cell proliferation was blocked by the specific inhibition of Unc5b expression with RNAi.
  • These data suggest that netrin-1 could be an endogenous trophic factor for Schwann cells in the injured peripheral nerves.
  • [MeSH-major] Nerve Growth Factors / administration & dosage. Receptors, Cell Surface / metabolism. Schwann Cells / metabolism. Sciatic Neuropathy / metabolism. Tumor Suppressor Proteins / administration & dosage
  • [MeSH-minor] Animals. Cell Line. Cell Proliferation / drug effects. Dose-Response Relationship, Drug. Male. Rats. Rats, Sprague-Dawley

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  • (PMID = 17825258.001).
  • [ISSN] 0006-291X
  • [Journal-full-title] Biochemical and biophysical research communications
  • [ISO-abbreviation] Biochem. Biophys. Res. Commun.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Nerve Growth Factors; 0 / Receptors, Cell Surface; 0 / Tumor Suppressor Proteins; 0 / Unc5b protein, rat; 158651-98-0 / netrin-1
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28. Consdorf NS, Wahlers B: [Benign mediastinal schwannoma of the left supraaortic branch of the vagus nerve]. Rofo; 2005 Nov;177(11):1588-9
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  • [Title] [Benign mediastinal schwannoma of the left supraaortic branch of the vagus nerve].
  • [Transliterated title] Benignes mediastinales Schwannom des linken supraaortalen Astes des Nervus vagus.
  • [MeSH-major] Cranial Nerve Neoplasms. Mediastinal Neoplasms. Neurilemmoma. Vagus Nerve Diseases

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  • (PMID = 16302144.001).
  • [ISSN] 1438-9029
  • [Journal-full-title] RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
  • [ISO-abbreviation] Rofo
  • [Language] ger
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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29. Dutta R, Kumar A, Jindal T, Tanveer N: Concurrent benign schwannoma of oesophagus and posterior mediastinum. Interact Cardiovasc Thorac Surg; 2009 Dec;9(6):1032-4
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  • [Title] Concurrent benign schwannoma of oesophagus and posterior mediastinum.
  • A 52-year-old female with recent onset dysphagia and haematemesis was found to have an intramural tumour of the oesophagus.
  • A separate tumour in the posterior mediastinum was also detected.
  • Both the tumours were immunohistochemically and histomorphologically compatible with benign schwannoma.
  • Oesophageal schwannoma is extremely rare and its association with a concurrent schwannoma in posterior mediastinum is not reported earlier in the literature.
  • [MeSH-major] Esophageal Neoplasms / diagnosis. Mediastinal Neoplasms / diagnosis. Neoplasms, Multiple Primary. Neurilemmoma / diagnosis

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  • (PMID = 19770133.001).
  • [ISSN] 1569-9285
  • [Journal-full-title] Interactive cardiovascular and thoracic surgery
  • [ISO-abbreviation] Interact Cardiovasc Thorac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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30. Yang I, Paik E, Huh NG, Parsa AT, Ames CP: Giant thoracic schwannoma presenting with abrupt onset of abdominal pain: a case report. J Med Case Rep; 2009;3:88
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  • [Title] Giant thoracic schwannoma presenting with abrupt onset of abdominal pain: a case report.
  • INTRODUCTION: Giant intradural extramedullary schwannomas of the thoracic spine are not common.
  • Schwannomas, that is, tumors derived from neoplastic Schwann cells, and neurofibromas represent the most common intradural extramedullary spinal lesions.
  • We report the case of a patient with a giant thoracic schwannoma presenting unusually with acute abdominal pain and with delayed neurological impairment.
  • After extensive work-up including an exploratory laparotomy for appendectomy, magnetic resonance imaging scans of the lumbar and thoracic spine revealed a giant intradural extramedullary thoracic schwannoma within the spinal canal posterior to the T9, T10, and T11 vertebral bodies.
  • Magnetic resonance imaging signal prolongation was noted in the spinal cord both rostral and caudal to the schwannoma.
  • After sacrificing the T10 root, the tumor was removed en bloc.
  • This referred pain may represent a mechanism by which a giant thoracic schwannoma may present as acute abdominal pain.
  • Acute, intense abdominal pain with delayed neurologic deficit is a rare presentation of a thoracic schwannoma but should be considered as a possible cause of abdominal pain presenting without clear etiology.

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  • (PMID = 19946504.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2783087
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31. Shantaram M, Rao A, Aroor AR, Raja A, Rao S, Monteiro F: Assessment of total sialic acid and lipid-bound sialic acid in management of brain tumors. Ann Indian Acad Neurol; 2009 Jul;12(3):162-6
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  • BACKGROUND: Glycoconjugate molecules expressed at the plasma membrane of mammalian cells have been reported to be associated with tumor progression.
  • OBJECTIVE: The objective of this study is to check the feasibility of using serum glycoconjugates such as TSA and LBSA as tumor markers in brain tumor patients.
  • The LBSA fraction was isolated from the serum of 68 brain tumor patients and evaluated using phosphotungstic acid and resorcinol; follow-up study was done on 23 patients.
  • The various types of brain tumors included in this study were glioma, meningioma, and acoustic neurinoma as well as some other types such as medulloblastoma, secondary tumors, and craniopharyngioma.
  • DISCUSSION: TSA and LBSA do not have the ability to discriminate between benign and malignant brain tumors.
  • TSA and LBSA appear to be tumor markers of very limited value in patients with brain tumors.

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  • (PMID = 20174496.001).
  • [ISSN] 1998-3549
  • [Journal-full-title] Annals of Indian Academy of Neurology
  • [ISO-abbreviation] Ann Indian Acad Neurol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2824932
  • [Keywords] NOTNLM ; Brain tumors / lipid-bound sialic acid / total sialic acid / tumor markers
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32. Cothren CC, Lutfiyya WL, Kim FJ, Ciesla DJ: Image of the month: Schwannoma. Arch Surg; 2006 Sep;141(9):941-2
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  • [Title] Image of the month: Schwannoma.
  • [MeSH-major] Neurilemmoma / surgery. Retroperitoneal Neoplasms / surgery

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  • (PMID = 16983038.001).
  • [ISSN] 0004-0010
  • [Journal-full-title] Archives of surgery (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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33. Gajda M, Zagólski O, Jasztal A, Lis GJ, Adamek D, Litwin JA: Giant schwannoma of the cheek--a comprehensive histological and immunohistochemical description of a rare tumour. Pol J Pathol; 2009;60(1):52-6
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  • [Title] Giant schwannoma of the cheek--a comprehensive histological and immunohistochemical description of a rare tumour.
  • Schwannoma is a benign tumour originating from Schwann cells forming sheaths of peripheral nerves.
  • A large tumour (5 cm) was surgically removed from the left cheek of a fifty-five-year-old man and pathological examination revealed schwannoma with Antoni A and B patterns.
  • The tumour was investigated using immunofluorescence and histochemical stainings.
  • SMA immunoreactivity was observed in walls of larger blood vessels but not in tumour cells.
  • The tumour contained numerous mast cells visualized by thionin staining and an abundance of collagen fibres revealed by picrosirius red.
  • [MeSH-major] Cheek. Mouth Neoplasms / diagnosis. Mouth Neoplasms / pathology. Neurilemmoma / diagnosis. Neurilemmoma / pathology

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  • (PMID = 19670705.001).
  • [ISSN] 1233-9687
  • [Journal-full-title] Polish journal of pathology : official journal of the Polish Society of Pathologists
  • [ISO-abbreviation] Pol J Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Collagen Type IV; 0 / S100 Proteins; EC 3.1.2.15 / UCHL1 protein, human; EC 3.1.2.15 / Ubiquitin Thiolesterase
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34. Löwenheim H, Koerbel A, Ebner FH, Kumagami H, Ernemann U, Tatagiba M: Differentiating imaging findings in primary and secondary tumors of the jugular foramen. Neurosurg Rev; 2006 Jan;29(1):1-11; discussion 12-13
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  • The preoperative diagnosis of a jugular foramen tumor may be challenging, since a large variety of unusual lesions may be located in this region.
  • Primary tumors include glomus jugulare tumors, schwannomas, meningiomas and peripheral primitive neuroectodermal tumors, while secondary tumors comprise chordomas, chondrosarcomas, chondroblastomas, giant-cell tumors, cholesterol granulomas, giant cholesterol cyst, endolymphatic sac tumors, reactive myofibroblastic tumors, temporal bone carcinomas and metastases.
  • [MeSH-major] Brain Neoplasms / diagnosis. Glomus Jugulare Tumor / diagnosis. Skull Base Neoplasms / diagnosis. Skull Neoplasms / diagnosis. Skull Neoplasms / secondary

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  • (PMID = 16283211.001).
  • [ISSN] 0344-5607
  • [Journal-full-title] Neurosurgical review
  • [ISO-abbreviation] Neurosurg Rev
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 70
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35. Parietti-Winkler C, Gauchard GC, Simon C, Perrin PP: Long-term effects of vestibular compensation on balance control and sensory organisation after unilateral deafferentation due to vestibular schwannoma surgery. J Neurol Neurosurg Psychiatry; 2010 Aug;81(8):934-6
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  • [Title] Long-term effects of vestibular compensation on balance control and sensory organisation after unilateral deafferentation due to vestibular schwannoma surgery.
  • The time-course of central adaptive mechanisms after vestibular schwannoma surgical removal allows, 3 months after surgery (middle term), a satisfactory recovery of balance control.
  • This longitudinal prospective study aimed to assess the long-term effects of vestibular compensation on balance control and sensory organisation in patients operated on for vestibular schwannoma.
  • Thirty-six patients with vestibular schwannoma underwent vestibular and sensory organisation tests, shortly before and 3 months, 6 months and 1 year after surgery.

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  • (PMID = 20682722.001).
  • [ISSN] 1468-330X
  • [Journal-full-title] Journal of neurology, neurosurgery, and psychiatry
  • [ISO-abbreviation] J. Neurol. Neurosurg. Psychiatry
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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36. Kim SB, Kim HS, Jang JS, Lee SH: Mobility of intradural extramedullary schwannoma at spine : report of three cases with literature review. J Korean Neurosurg Soc; 2010 Jan;47(1):64-7
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  • [Title] Mobility of intradural extramedullary schwannoma at spine : report of three cases with literature review.
  • Although very rare, a few cases of intradural extramedullary (IDEM) spinal tumor migration have been reported since Tomimatsu first reported a mobile schwannoma of the cervical cord in 1974.
  • Schwannoma is a neurogenic tumor which originates from nerve sheath that it is relatively well-marginated tumor with little attachment or adhesion to surrounding tissue.
  • Mobility of tumor in spinal canal sometimes can result in negative exploration at the expected area.
  • We found three interesting cases in which different tumor locations observed in repeated magnetic resonance image (MRI) findings.
  • All tumors were intradural and extramedullary schwannoma.
  • We reviewed the literature about moving tumor in the spine through PUBMED search.

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  • (PMID = 20157382.001).
  • [ISSN] 1598-7876
  • [Journal-full-title] Journal of Korean Neurosurgical Society
  • [ISO-abbreviation] J Korean Neurosurg Soc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2817519
  • [Keywords] NOTNLM ; Intradural extramedullary / Mobility / Schwannoma
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37. Hijioka S, Sawaki A, Mizuno N, Hara K, Mekky MA, Bhatia V, Hosoda W, Yatabe Y, Shimizu Y, Tamada K, Niwa Y, Yamao K: Endoscopic ultrasound-guided fine-needle aspiration for the diagnosis of retroperitoneal schwannoma. Endoscopy; 2010;42 Suppl 2:E296
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  • [Title] Endoscopic ultrasound-guided fine-needle aspiration for the diagnosis of retroperitoneal schwannoma.
  • [MeSH-major] Endosonography. Neurilemmoma / pathology. Retroperitoneal Neoplasms / pathology

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  • (PMID = 21113878.001).
  • [ISSN] 1438-8812
  • [Journal-full-title] Endoscopy
  • [ISO-abbreviation] Endoscopy
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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38. Braumann C, Guenther N, Menenakos C, Junghans T: Schwannoma of the colon mimicking carcinoma: a case report and literature review. Int J Colorectal Dis; 2007 Dec;22(12):1547-1548
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  • [Title] Schwannoma of the colon mimicking carcinoma: a case report and literature review.
  • [MeSH-major] Carcinoma / diagnosis. Colonic Neoplasms / diagnosis. Neurilemmoma / diagnosis

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  • (PMID = 17242938.001).
  • [ISSN] 0179-1958
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Case Reports; Letter; Review
  • [Publication-country] Germany
  • [Number-of-references] 0
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39. Tsuchiya K, Honya K, Yoshida M, Nitatori T: Demonstration of spinal cord and nerve root abnormalities by diffusion neurography. J Comput Assist Tomogr; 2008 Mar-Apr;32(2):286-90
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  • METHODS: We applied this technique to 18 patients with miscellaneous pathological conditions that included multiple sclerosis, chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), neurofibromatosis (NF), schwannoma, cord injury, and tethered cord.
  • This technique demonstrated cord plaques of multiple sclerosis (5/6 cases), enlarged nerve roots in CIDP (3/3 cases), multiple neurogenic tumors in NF (3/3 cases), and schwannoma (1/1 case).

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  • (PMID = 18379319.001).
  • [ISSN] 0363-8715
  • [Journal-full-title] Journal of computer assisted tomography
  • [ISO-abbreviation] J Comput Assist Tomogr
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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40. Tremblay N, Lanevschi A, Doré M, Lanthier I, Desnoyers M: Of all the nerve! A subcutaneous forelimb mass on a cat. Vet Clin Pathol; 2005 Dec;34(4):417-20
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  • The cytologic diagnosis was malignant neoplasia of probable mesenchymal or round cell origin.
  • Malignant fibrous histiocytoma was tentatively diagnosed histologically; however, the tumor cells subsequently were found to be negative for histiocytic (MAC 387, antitrypsin), T-cell (CD3), and B-lymphocyte (immunoglobulin light chains, Ly 5/CD45R) markers, and positive for glial fibrillary acidic protein, vimentin, and S-100.
  • Based on the immunohistochemical results, the diagnosis was modified to malignant peripheral nerve sheath tumor (PNST).
  • PNSTs are rare tumors in cats, and are considered as synonymous with schwannomas, neurofibrosarcomas, and hemangiopericytomas.

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  • (PMID = 16270272.001).
  • [ISSN] 0275-6382
  • [Journal-full-title] Veterinary clinical pathology
  • [ISO-abbreviation] Vet Clin Pathol
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein; 0 / S100 Proteins; 0 / Vimentin
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41. Ahmad SM, Garcia F, Sataloff RT: Cerebellopontine angle ganglionic hamartoma: case report. Ear Nose Throat J; 2010 Mar;89(3):128-31
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  • We present a case of a 49-year-old woman who presented with left-sided hearing loss of more than 4 years' duration and vertigo since childhood.
  • Magnetic resonance imaging revealed a mass on the intracanalicular segment of cranial nerve VIII on the left side, consistent with acoustic schwannoma.
  • She opted for observation of the tumor.
  • Otolaryngologists should be familiar with this uncommon tumor and include it in the differential diagnosis of CPA lesions.

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  • (PMID = 20229478.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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42. Koscielny S, Sölch O: [Therapy of a schwannoma of the vagal nerve--stated at the example of an extensive tumor]. Laryngorhinootologie; 2008 Sep;87(9):647-50
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  • [Title] [Therapy of a schwannoma of the vagal nerve--stated at the example of an extensive tumor].
  • [Transliterated title] Behandlungsstrategien eines Schwannoms des Nervus vagus am Beispiel des interdisziplinären Vorgehens bei einem ausgedehnten Tumor.
  • INTRODUCTION: Schwannoma of the vagal nerve are rare and usually accidentally found by exploring a slowly growing and painless neck tumor.
  • CASE: We report on a 49-year-old patient with an extensive schwannoma of the vagal nerve.
  • The tumor grew from the brainstem to the lower neck vessel sheath and destroyed the skull base.
  • The tumor had already involved all nerves of the foramen jugulare.
  • Initially the cervical part of the tumor was removed by transcervical approach.
  • Then the endocranial part of the tumor was removed by retrosigmoidal craniotomy and partial petrosectomy.
  • DISCUSSION: We have observed 5 schwannomas of the vagal nerve in 47,000 patients for 16 years.
  • In case of an intact nerve and after verifying the diagnosis of a schwannoma a detailed information given to the patient is absolutely necessary before any intervention.
  • If the nerve lost its function there are no contraindications to resect the tumor and the nerve.
  • [MeSH-major] Cranial Nerve Neoplasms / surgery. Neurilemmoma / surgery. Vagus Nerve Diseases / surgery

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  • (PMID = 18726862.001).
  • [ISSN] 0935-8943
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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43. Noah MA, Gorecha M, Firmin RK: Primary benign bronchial schwannoma presenting as asthma. J Asthma; 2009 Oct;46(8):856-7
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  • [Title] Primary benign bronchial schwannoma presenting as asthma.
  • Bronchoscopy revealed a right main bronchus tumor, which was diagnosed as bronchial schwannoma after resection by sleeve lobectomy.
  • We review the literature on this tumor.
  • [MeSH-major] Asthma / diagnosis. Bronchial Neoplasms / diagnosis. Neurilemmoma / diagnosis

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  • (PMID = 19863293.001).
  • [ISSN] 1532-4303
  • [Journal-full-title] The Journal of asthma : official journal of the Association for the Care of Asthma
  • [ISO-abbreviation] J Asthma
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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44. Zolotova SV, Nikonova NG: [Stereotactic radiosurgical treatment of patients with vestibular schwannomas]. Zh Vopr Neirokhir Im N N Burdenko; 2009 Apr-Jun;(2):55-60; discussion 61
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  • [Title] [Stereotactic radiosurgical treatment of patients with vestibular schwannomas].

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  • (PMID = 19569550.001).
  • [ISSN] 0042-8817
  • [Journal-full-title] Zhurnal voprosy neĭrokhirurgii imeni N. N. Burdenko
  • [ISO-abbreviation] Zh Vopr Neirokhir Im N N Burdenko
  • [Language] rus
  • [Publication-type] Journal Article; Review
  • [Publication-country] Russia (Federation)
  • [Number-of-references] 125
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45. Chi FL, Wang ZM, Chen ZY, Wu YZ: [Diagnosis and management of facial nerve neuromas]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2006 Apr;41(4):262-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To provide the experience for early diagnosis and management of facial nerve neuromas, and to discuss the clinic and imaging feature of facial nerve schwannoma and facial nerve fibroma in 22 cases.
  • METHODS: Twenty cases facial nerve schwannoma and two cases of facial nerve neurofibroma were diagnosed and reviewed retrospectively.
  • The CT imaging of the temporal bone showed that schwannoma was separated "white mass" with smooth margin along the region of facial nerve without intact canal.
  • Pathological results indicated that 20 cases were diagnosed as facial nerve schwannoma and 2 cases were neurofibroma.
  • CONCLUSIONS: Although tumors originating from the facial nerve are extremely rare, it is possible to make early diagnosis through finding clinical feature and imaging methods.
  • Generally, systematic surgical approach for tumor removal and facial nerve reconstruction should be considered in the cases with facial neurinoma.
  • [MeSH-major] Cranial Nerve Neoplasms / diagnosis. Facial Nerve. Neurilemmoma / diagnosis. Neurofibroma / diagnosis

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  • (PMID = 16848173.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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46. Jeon CJ, Kong DS, Nam DH, Lee JI, Park K, Kim JH: Communicating hydrocephalus associated with surgery or radiosurgery for vestibular schwannoma. J Clin Neurosci; 2010 Jul;17(7):862-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Communicating hydrocephalus associated with surgery or radiosurgery for vestibular schwannoma.
  • The purpose of this cohort study was to determine the incidence of communicating hydrocephalus (HCP) associated with the treatment of vestibular schwannoma (VS).
  • During their clinical course, 10 of 291 patients developed new communicating HCP (3.4%): nine of 90 patients who were treated using GKS (10%) developed communicating HCP post-procedure, while only one of 146 patients who underwent surgical resection alone (0.68%) developed subsequent communicating HCP (p=0.002).
  • Three patients who developed new communicating HCP in the GKS group required surgical intervention, including ventriculoperitoneal shunt or endoscopic third ventriculostomy.
  • There was no significant correlation between sex or tumor size and the incidence of communicating HCP in the GKS group (p>0.05).
  • Therefore, the risk of communicating HCP should be considered in the follow-up of patients who undergo GKS for treatment of vs.


47. Stangerup SE, Tos M, Thomsen J, Caye-Thomasen P: True incidence of vestibular schwannoma? Neurosurgery; 2010 Nov;67(5):1335-40; discussion 1340
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] True incidence of vestibular schwannoma?
  • BACKGROUND: The incidence of diagnosed sporadic unilateral vestibular schwannomas (VS) has increased, due primarily to more widespread access to magnetic resonance imaging.
  • OBJECTIVE: To present updated epidemiological data on VS incidence, as well as patient age, hearing acuity, tumor size, and localization at diagnosis for the last 4 decades in an unselected population, with emphasis on developments in recent years.
  • Incidence during the period, patient sex and age, data on hearing (pure tone average and speech discrimination), and tumor size at diagnosis were retrieved from the database.
  • Mean tumor size at diagnosis decreased from 30 mm in 1979 to 10 mm in 2008, whereas hearing acuity at diagnosis has improved over the years.
  • CONCLUSION: After a steady increase over the last 4 decades, the incidence of vestibular schwannomas appears to have peaked and decreased in recent years, stabilizing at about 19 tumors per million per year.
  • Whereas the sex ratio and age at diagnosis have remained grossly unchanged over the years, hearing has improved, and tumor size has decreased considerably.

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  • (PMID = 20871439.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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48. Winters R, Moroz K, Friedlander P: Pathology quiz case 1. Schwannoma with ancient change. Arch Otolaryngol Head Neck Surg; 2008 Sep;134(9):1012, 1014
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  • [Title] Pathology quiz case 1. Schwannoma with ancient change.
  • [MeSH-major] Neurilemmoma / pathology. Parotid Neoplasms / pathology

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  • (PMID = 18794451.001).
  • [ISSN] 1538-361X
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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49. Godefroy WP, Hastan D, van der Mey AG: Translabyrinthine surgery for disabling vertigo in vestibular schwannoma patients. Clin Otolaryngol; 2007 Jun;32(3):167-72
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  • [Title] Translabyrinthine surgery for disabling vertigo in vestibular schwannoma patients.
  • OBJECTIVE: To determine the impact of translabyrinthine surgery on the quality of life in vestibular schwannoma patients with rotatory vertigo.
  • STUDY DESIGN: Prospective study in 18 vestibular schwannoma patients.
  • PARTICIPANTS: All 18 patients had a unilateral intracanalicular vestibular schwannoma, without serviceable hearing in the affected ear and severely handicapped by attacks of rotatory vertigo and constant dizziness.
  • CONCLUSIONS: Vestibular schwannoma patients with disabling vertigo, experience significant reduced quality of life when compared with a healthy Dutch population.
  • Translabyrinthine tumour removal significantly improved the patients' quality of life.

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  • (PMID = 17550503.001).
  • [ISSN] 1749-4478
  • [Journal-full-title] Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery
  • [ISO-abbreviation] Clin Otolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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50. Tokunaga T, Takeda S, Sumimura J, Maeda H: Esophageal schwannoma: report of a case. Surg Today; 2007;37(6):500-2
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  • [Title] Esophageal schwannoma: report of a case.
  • We report a case of esophageal schwannoma in a 46-year-old woman who presented with rapidly progressive dyspnea and dysphagia.
  • We performed an axillary right thoracotomy to enucleate the tumor, which was located in the esophageal muscle layer.
  • A definite diagnosis of esophageal schwannoma was made from the pathologic findings, which included positive immunohistochemical staining for S-100 protein and negative staining for c-kit and CD34.
  • [MeSH-major] Esophageal Neoplasms / diagnosis. Neurilemmoma / diagnosis

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  • [Cites] J Gastroenterol. 2001 Nov;36(11):772-7 [11757750.001]
  • [Cites] J Clin Pathol. 2002 Apr;55(4):318-20 [11919222.001]
  • [Cites] Gastroenterol Hepatol. 2004 Oct;27(8):467-9 [15388051.001]
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  • (PMID = 17522770.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / S100 Proteins; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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51. Shimizu S, Tanaka R, Oka H, Fujii K: Risk of damage to the endolymphatic sac and duct during removal of the posterior meatal wall: an anatomic study. Neurosurgery; 2006 Oct;59(4 Suppl 2):ONS435-9; discussion ONS439-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: With removal of the posterior meatal wall for intrameatal acoustic neurinoma, preservation of the structures adjacent to the internal acoustic meatus is important.

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  • (PMID = 17041514.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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52. Gouveris H, Akkafa S, Lippold R, Mann W: Influence of nerve of origin and tumor size of vestibular schwannoma on dynamic posturography findings. Acta Otolaryngol; 2006 Dec;126(12):1281-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Influence of nerve of origin and tumor size of vestibular schwannoma on dynamic posturography findings.
  • CONCLUSION: Condition 5-score (C5S) and vestibular ratio (VER) correlate, but condition-6-score (C6S) and mean overall balance score (MOBS) do not, with the size of an inferior vestibular nerve (IVN) vestibular schwannoma (VS).
  • Spearman's rank correlation coefficients were calculated between the tumor's larger dimension and each of the four parameters for SVN and IVN vs. The nerve of VS origin was identified intraoperatively.
  • Neither C6S nor MOBS showed any significant correlation with the tumor's larger dimension.

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  • (PMID = 17101589.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Norway
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53. Gazzeri R, Galarza M, Costanzo de B, Carotenuto V, D'Angelo V: Large pure intracranial vagal schwannoma. J Clin Neurosci; 2009 Apr;16(4):565-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Large pure intracranial vagal schwannoma.
  • We report a patient with a large, pure intracranial vagal schwannoma, compressing the medulla who presented with essential hypertension.
  • Based on this and on previous cases, we suggest that a differentiation of pure intracranial schwannomas (subtype A1) from intracranial schwannomas with some extension in the jugular foramen (type A) should be used.
  • [MeSH-major] Brain Neoplasms / pathology. Cranial Nerve Neoplasms / complications. Neurilemmoma / pathology. Vagus Nerve Diseases

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  • (PMID = 19200737.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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54. Tombesi P, Sartori S, Postorivo S, Guerrini G, Turlà G, De Giorgi A, Querzoli G, Rinaldi S, Fabbian F: Contrast-enhanced ultrasonographically guided percutaneous biopsy in the diagnosis of paravertebral schwannoma. J Ultrasound Med; 2009 Dec;28(12):1747-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Contrast-enhanced ultrasonographically guided percutaneous biopsy in the diagnosis of paravertebral schwannoma.
  • [MeSH-major] Biopsy, Needle / methods. Neurilemmoma / ultrasonography. Phospholipids. Spinal Neoplasms / ultrasonography. Sulfur Hexafluoride. Thoracic Neoplasms / ultrasonography. Ultrasonography, Interventional / methods

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  • (PMID = 19933493.001).
  • [ISSN] 1550-9613
  • [Journal-full-title] Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
  • [ISO-abbreviation] J Ultrasound Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Phospholipids; 0 / contrast agent BR1; WS7LR3I1D6 / Sulfur Hexafluoride
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55. Alfonso C, Lassaletta L, Sarriá J, Gavilán J: [Quality of life following vestibular schwannoma surgery]. Acta Otorrinolaringol Esp; 2007 Feb;58(2):61-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Quality of life following vestibular schwannoma surgery].
  • [Transliterated title] Calidad de vida tras la cirugía del schwannoma vestibular.
  • OBJECTIVE: This study evaluates quality of life (QOL) in patients following surgery for vestibular schwannoma (VS) using the Glasgow Benefit Inventory (GBI), and a pain questionnaire.
  • MATERIAL AND METHOD: The questionnaires were sent to 95 patients who had undergone surgery at our institution.
  • No differences in postoperative QOL were found when comparing side, gender, age, tumor size, hearing preservation, or post-operative facial function.

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  • (PMID = 17371684.001).
  • [ISSN] 0001-6519
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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56. Yu LM, Yang SM, Han DY, Yu LM, Yang WY: [Preliminary study of intraoperative auditory monitoring techniques in acoustic neuroma surgery]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2006 May;41(5):335-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The hearing was preserved in 2 cases, which had class A hearing post operation with tumor size <2 cm.
  • In another case, the waves of I, III could be evoked after the tumor resection with the disappearance of wave V.
  • The CAP amplitudes decreased significantly in 4 cases and even dropped to zero while dissecting the tumor at the lateral end of the internal auditory canal (IAC) or clamping the internal auditory artery (IAA) during operation.
  • In one case, although the cochlear nerve was cut down, the CAP could still be recorded after the tumor resection.
  • One of them showed low amplitude of CAP wave when the tumor partially removed.
  • CONCLUSIONS: In combination with ABR monitoring, ECochG proved to be a useful supplementary tool for hearing preservation in acoustic neurinoma surgery.
  • Drilling of the IAC and tumor removal at the lateral end of the IAC were the most critical steps for achieving hearing preservation.

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  • (PMID = 16848284.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] China
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57. Sadok Boudaya M, Dechaud C, Gossot D, Validire P, Magdeleinat P, Moretti JL: [Benign schwannoma with high uptake of 18 fluorodeoxglucose (PET-Scan)]. Rev Mal Respir; 2009 Jan;26(1):63-5
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  • [Title] [Benign schwannoma with high uptake of 18 fluorodeoxglucose (PET-Scan)].
  • [Transliterated title] Un cas de schwannome bénin avec hypermétabolisme sur la tomoscintigraphie TEP au 18fluorodésoxyglucose.
  • The lesion was actually a benign schwannoma.
  • CONCLUSIONS: In the case of a mediastinal mass with conventional imaging being in favour of a neurogenic tumour a PET scan cannot confirm benignity or malignancy.
  • [MeSH-major] Mediastinal Neoplasms / radionuclide imaging. Neurilemmoma / radionuclide imaging. Positron-Emission Tomography

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  • (PMID = 19212292.001).
  • [ISSN] 0761-8425
  • [Journal-full-title] Revue des maladies respiratoires
  • [ISO-abbreviation] Rev Mal Respir
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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58. Kim HT, Gim TJ, Lee JH: Transient cauda equina syndrome related to a sacral schwannoma with cauda equine compression after a lumbar epidural block -A case report-. Korean J Anesthesiol; 2010 Dec;59 Suppl:S222-5
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  • [Title] Transient cauda equina syndrome related to a sacral schwannoma with cauda equine compression after a lumbar epidural block -A case report-.
  • The MRI revealed a schwannoma at the S3 level of the sacral spine with cauda equina compression.

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  • [Cites] Spine (Phila Pa 1976). 2002 Jan 1;27(1):11-6 [11805628.001]
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  • (PMID = 21286446.001).
  • [ISSN] 2005-7563
  • [Journal-full-title] Korean journal of anesthesiology
  • [ISO-abbreviation] Korean J Anesthesiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC3030042
  • [Keywords] NOTNLM ; Cauda equina syndrome / Low back pain / Schwannoma
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59. von Eckardstein KL, Beatty CW, Driscoll CL, Link MJ: Spontaneous regression of vestibular schwannomas after resection of contralateral tumor in neurofibromatosis Type 2. J Neurosurg; 2010 Jan;112(1):158-62
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  • [Title] Spontaneous regression of vestibular schwannomas after resection of contralateral tumor in neurofibromatosis Type 2.
  • The authors report on 2 patients with bilateral vestibular schwannomas (VSs) who underwent unilateral surgical tumor removal.
  • Serial MR imaging was performed to monitor the untreated tumor, which in both cases involved the only hearing ear.
  • The mechanism of the dramatic spontaneous tumor regression is uncertain.


60. Kiyomizu K, Matsuda K, Nakayama M, Tono T, Matsuura K, Kawano H, Toyama K, Komune S: Preservation of the auditory nerve function after translabyrinthine removal of vestibular schwannoma. Auris Nasus Larynx; 2006 Mar;33(1):7-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Preservation of the auditory nerve function after translabyrinthine removal of vestibular schwannoma.
  • OBJECTIVE: To evaluate the function of the postoperative auditory nerve preserved after translabyrinthine (TL) vestibular schwannoma (VS) removal.
  • METHODS: Fifteen patients, who underwent unilateral VS resection via a TL approach, were preserved auditory nerve anatomically.
  • The maximum tumor size in the group with a positive response to EST or EABR was significantly smaller than that in the group with a negative response to EST.
  • It seems to be difficult to preserve auditory nerve function in cases where a tumor extends to the fundus of internal auditory canal.
  • CONCLUSION: These results suggest that size of tumor and/or extension of tumor to the fundus might be important factors in preserving the auditory nerve function even if using a TL approach.


61. Scoles DR, Qin Y, Nguyen V, Gutmann DH, Pulst SM: HRS inhibits EGF receptor signaling in the RT4 rat schwannoma cell line. Biochem Biophys Res Commun; 2005 Sep 23;335(2):385-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] HRS inhibits EGF receptor signaling in the RT4 rat schwannoma cell line.
  • Hepatocyte growth factor-regulated tyrosine kinase substrate (HRS) is required for trafficking of cell surface receptors to the lysosome.
  • Previously, we identified HRS as a protein that interacts with the neurofibromatosis 2 tumor suppressor schwannomin.
  • In the present study, we established modified RT4 schwannoma cell lines that inducibly express HRS and constitutively express epidermal growth factor receptor (EGFR) fused to the green fluorescent protein.
  • This study is the first to show that HRS can reduce the abundance of total and active EGFR and may reflect cell type-specific HRS function.
  • [MeSH-major] Neurilemmoma / metabolism. Phosphoproteins / physiology. Receptor, Epidermal Growth Factor / metabolism
  • [MeSH-minor] Animals. Cell Line, Tumor. Dose-Response Relationship, Drug. Down-Regulation. Endosomal Sorting Complexes Required for Transport. Endosomes / metabolism. Green Fluorescent Proteins / metabolism. Immunoblotting. Microscopy, Fluorescence. Neurofibromin 2 / metabolism. Phosphorylation. Rats. Signal Transduction. Time Factors

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  • (PMID = 16083858.001).
  • [ISSN] 0006-291X
  • [Journal-full-title] Biochemical and biophysical research communications
  • [ISO-abbreviation] Biochem. Biophys. Res. Commun.
  • [Language] eng
  • [Grant] United States / NINDS NIH HHS / NS / NS01428-01A1; United States / NINDS NIH HHS / NS / NS35848
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Endosomal Sorting Complexes Required for Transport; 0 / Neurofibromin 2; 0 / Phosphoproteins; 0 / hepatocyte growth factor-regulated tyrosine kinase substrate; 147336-22-9 / Green Fluorescent Proteins; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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62. Uchida N, Yokoo H, Kuwano H: Schwannoma of the breast: report of a case. Surg Today; 2005;35(3):238-42
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  • [Title] Schwannoma of the breast: report of a case.
  • This report describes a rare case of a schwannoma that developed in the left breast of a 45-year-old woman without von Recklinghausen's disease.
  • On ultrasonography the lesion was found to be a well-demarcated, hypoechoic mass including a large cystic area, which led to the suspicion of a phyllodes tumor.
  • These findings were compatible with schwannoma.
  • A review of the English literature yielded 21 proven cases of breast schwannoma.
  • [MeSH-major] Breast Neoplasms / diagnosis. Breast Neoplasms / surgery. Neurilemmoma / diagnosis. Neurilemmoma / surgery

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  • (PMID = 15772796.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 22
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63. Møller AR: Physiological basis for cochlear and auditory brainstem implants. Adv Otorhinolaryngol; 2006;64:206-23
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  • However, experience from the use of ABIs in patients with bilateral vestibular schwannoma has not been encouraging, but recent studies of the use of ABIs in patients with other causes of injuries to the auditory nerve have shown similar speech discrimination as achieved with modern cochlear implants.

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  • (PMID = 16891844.001).
  • [ISSN] 0065-3071
  • [Journal-full-title] Advances in oto-rhino-laryngology
  • [ISO-abbreviation] Adv. Otorhinolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 54
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64. Hattab EM, Tu PH, Wilson JD, Cheng L: OCT4 immunohistochemistry is superior to placental alkaline phosphatase (PLAP) in the diagnosis of central nervous system germinoma. Am J Surg Pathol; 2005 Mar;29(3):368-71
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  • It is expressed in mouse and human embryonic stem and germ cells but absent from all differentiated somatic cell types in vitro and in vivo.
  • OCT4 has been detected in primary testicular germ cell tumors with pluripotent potential: seminoma and embryonal carcinoma.
  • All but one germinoma were pure (ie, lacking other germ cell components).
  • None of the 49 control cases, which included glioblastoma multiforme, pineoblastoma, pituitary adenoma, malignant lymphoma, metastatic melanoma, capillary hemangioblastoma, meningioma, schwannoma, and a variety of metastatic carcinomas showed immunoreactivity for OCT4.
  • [MeSH-minor] Alkaline Phosphatase. Biomarkers, Tumor / metabolism. Female. GPI-Linked Proteins. Humans. Male. Octamer Transcription Factor-3. Ovarian Neoplasms / diagnosis. Ovarian Neoplasms / metabolism. Ovarian Neoplasms / pathology. Sensitivity and Specificity. Testicular Neoplasms / diagnosis. Testicular Neoplasms / metabolism. Testicular Neoplasms / pathology

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  • (PMID = 15725806.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / GPI-Linked Proteins; 0 / Isoenzymes; 0 / Octamer Transcription Factor-3; 0 / POU5F1 protein, human; 0 / Transcription Factors; EC 3.1.3.1 / Alkaline Phosphatase; EC 3.1.3.1 / alkaline phosphatase, placental
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65. Pytel P, Karrison T, Can Gong, Tonsgard JH, Krausz T, Montag AG: Neoplasms with schwannian differentiation express transcription factors known to regulate normal schwann cell development. Int J Surg Pathol; 2010 Dec;18(6):449-57
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  • [Title] Neoplasms with schwannian differentiation express transcription factors known to regulate normal schwann cell development.
  • A number of transcription factors have been identified as important in guiding normal Schwann cell development.
  • This study used immunohistochemistry on tissue arrays to assess the expression of some of these transcription factors (Sox5, Sox9, Sox10, AP-2α, Pax7, and FoxD3) on 76 schwannomas, 105 neurofibromas, and 34 malignant peripheral nerve sheath tumors (MPNSTs).
  • Sox9 and Sox10 were found to be widely expressed in all tumor types.
  • FoxD3 reactivity was stronger and more frequently found in schwannomas and MPNSTs than neurofibromas.
  • AP-2α was positive in 31% to 49% of all tumors, but strong reactivity was limited to MPNSTs and schwannomas.
  • Statistical analysis showed significant differences between the 3 tumor types in the expression of these markers.
  • No differences were found in the analyzed tumor subgroups, including schwannomas of different sites, schwannomas with or without NF2 association, neurofibromas of different types, or sporadic versus NF1-associated MPNSTs.
  • These results suggest that the transcription factors that guide normal Schwann cell development also play a role in the biology of neoplastic cells with Schwannian differentiation.
  • Screening the expression of FoxD3, Sox9, and Sox10 on 23 cases of other spindle-cell proliferations that may be considered in the differential diagnosis of MPNST, including synovial sarcoma and spindle cell melanoma, suggests that these 3 are helpful markers of Schwannian differentiation in the context of diagnosing MPNSTs.
  • [MeSH-major] Peripheral Nervous System Neoplasms / metabolism. Schwann Cells / metabolism. Transcription Factors / metabolism
  • [MeSH-minor] Cell Differentiation. Humans. Immunohistochemistry. Tissue Array Analysis

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  • (PMID = 20034979.001).
  • [ISSN] 1940-2465
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Transcription Factors
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66. Konishi S, Nakamura H, Kato M, Toyoda H, Dozono M: Cauda equina tumor mimicking an intradural disc herniation, with emphasis on differential diagnosis--a case report. Acta Neurol Belg; 2008 Dec;108(4):167-9
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  • [Title] Cauda equina tumor mimicking an intradural disc herniation, with emphasis on differential diagnosis--a case report.
  • We report a rare case of lumbar disc prolapse with intradural schwannoma at the same level.
  • An intradural tumor that was iso-intense on T1-weighted and slightly hyperintense on T2-weighted images was also recognized at the same level.
  • The tumor was homogeneously enhanced on Gadolinium-MRI (Gd-MRI).
  • Intractable back and leg pain necessitated surgical treatment, which yielded a definitive diagnosis of the intradural tumor as schwannoma on histological examination.
  • The patient's intractable and prolonged pain appeared to be due to combined compression by the intradural tumor and disc prolapse.
  • [MeSH-major] Cauda Equina. Intervertebral Disc Displacement / diagnosis. Lumbar Vertebrae. Neurilemmoma / diagnosis. Peripheral Nervous System Neoplasms / diagnosis

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  • (PMID = 19239048.001).
  • [ISSN] 0300-9009
  • [Journal-full-title] Acta neurologica Belgica
  • [ISO-abbreviation] Acta Neurol Belg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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67. Ihrler S, Schwarz S, Zengel P, Guntinas-Lichius O, Kirchner T, Weiler C: [Pleomorphic adenoma: pitfalls and clinicopathological forms of progression]. Pathologe; 2009 Nov;30(6):446-56
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  • In "monomorphic" types of PA problems may result: Epithelial-rich PA need to be distinguished from basal cell adenoma or canalicular adenoma.
  • PA dominated by mesenchymal, spindle-shaped differentiation need to be distinguished from myoepithelioma or soft tissue tumours like schwannoma.
  • Focal biphasic-tubular differentiation with CK7/18-positive ductal cells is good evidence for a tumour within the wide spectrum of PA.
  • [MeSH-minor] Biomarkers, Tumor / analysis. Cell Transformation, Neoplastic / pathology. Diagnosis, Differential. Disease Progression. Female. Humans. Middle Aged. Neoplasm Invasiveness. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Neoplasm Staging. Reoperation. Salivary Ducts / pathology. Salivary Glands / pathology

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  • (PMID = 19844715.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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68. Kakigi A, Nishimura M, Takeda T, Taguchi D, Nishioka R: Expression of aquaporin1, 3, and 4, NKCC1, and NKCC2 in the human endolymphatic sac. Auris Nasus Larynx; 2009 Apr;36(2):135-9
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  • METHODS: A sample of human ES was harvested during the removal of vestibular schwannoma via the translabyrinthine approach.

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  • (PMID = 18606512.001).
  • [ISSN] 1879-1476
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / AQP3 protein, human; 0 / AQP4 protein, human; 0 / Aquaporin 4; 0 / SLC12A1 protein, human; 0 / SLC12A2 protein, human; 0 / Sodium-Potassium-Chloride Symporters; 0 / Solute Carrier Family 12, Member 1; 0 / Solute Carrier Family 12, Member 2; 146410-94-8 / Aquaporin 1; 158801-98-0 / Aquaporin 3
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69. Schmerber S, Palombi O, Boubagra K, Charachon R, Chirossel JP, Gay E: Long-term control of vestibular schwannoma after a translabyrinthine complete removal. Neurosurgery; 2005 Oct;57(4):693-8; discussion 693-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-term control of vestibular schwannoma after a translabyrinthine complete removal.
  • OBJECTIVE: The goal of this study was to determine the rate of recurrent vestibular schwannoma after a total removal via the translabyrinthine approach.
  • None of the 91 patients experienced a recurrent vestibular schwannoma on MRI.
  • CONCLUSION: The translabyrinthine approach is a safe procedure for total definitive removal of a vestibular schwannoma and permitted the absence of tumoral recurrence in our series of 91 patients.

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  • (PMID = 16239881.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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70. Ito Y, Tanaka N: [Mediastinal neurinoma originating from the intrathoracic vagal nerve: report of a case]. Kyobu Geka; 2009 Jun;62(6):513-5
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  • [Title] [Mediastinal neurinoma originating from the intrathoracic vagal nerve: report of a case].
  • Computed tomography (CT) and magnetic imaging resonance (MRI) showed that the tumor was located in the mediastinum in contact with the aorta and pulmonary artery.
  • Under the diagnosis of benign mediastinal tumor, video-assisted thoracic surgery was performed.
  • The tumor was about 6 cm in diameter and originated from the left vagal nerve.
  • [MeSH-major] Mediastinal Neoplasms / surgery. Mediastinum / innervation. Neurilemmoma / surgery. Vagus Nerve / surgery

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  • (PMID = 19522217.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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71. Roche PH, Ribeiro T, Fournier HD, Thomassin JM: Vestibular schwannomas: complications of microsurgery. Prog Neurol Surg; 2008;21:214-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Vestibular schwannomas: complications of microsurgery.
  • Current microsurgical treatment of vestibular schwannomas usually brings satisfactory results for the patients.
  • Based on their personal experience of large operated vestibular schwannomas and analyzing a review of the international literature, the authors detail these complications and the way to prevent and manage them.

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  • (PMID = 18810222.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 18
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72. Grasa Arnal AM, Abad Roger J, Bono Ariño A, Vera Alvarez JJ, Sanz Vélez JI: [Old schwannoma: a rare type of schwannoma]. Arch Esp Urol; 2005 Mar;58(2):164-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Old schwannoma: a rare type of schwannoma].
  • [Transliterated title] Schwannoma antiguo: variante rara de schwannoma.
  • OBJECTIVES: We report one case of retroperitoneal schwannoma with unfrequent histological characteristics evaluating its clinical significance and therapeutic options.
  • METHODS: We report the case of a benign retroperitoneal schwannoma as an incidental MRI finding in a 70 year-old female patient with symptoms of lumbosciatic pain for 6 months.
  • RESULTS: After surgical excision the diagnosis was retroperitoneal old schwannoma.
  • The histological changes apparent in the cases of old schwannoma have been interpreted as degenerative, indicating a long evolution, which has motivated its denomination as old.
  • CONCLUSIONS: The old schwannoma is a rare variety of the benign common schwannoma.
  • Therapeutic management is similar to other benign retroperitoneal processes, surgical excision and follow-up.
  • [MeSH-major] Neurilemmoma / pathology. Retroperitoneal Neoplasms / pathology

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  • (PMID = 15847275.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 10
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73. Kunieda E, Deloar HM, Kitamura M, Kawaguchi O, Shiba H, Takeda A, Kawase T, Seki S, Shigematsu N, Kubo A: Rotational and translational reproducibility of newly developed Leksell frame-based relocatable fixation system. Radiat Med; 2006 Aug;24(7):503-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • MATERIALS AND METHODS: We analyzed 17 series of QA-CT data representing five patients who underwent stereotactic radiotherapy for treatment of acoustic neurinoma.

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  • (PMID = 17058144.001).
  • [ISSN] 0288-2043
  • [Journal-full-title] Radiation medicine
  • [ISO-abbreviation] Radiat Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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74. Robles SG, Saldaña C, Boto GR, Martinez A, Zamarron AP, Jorquera M, Mata P: Intradural extramedullary spinal ependymoma: a benign pathology? Spine (Phila Pa 1976); 2005 May 1;30(9):E251-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intradural extramedullary spinal ependymoma: a benign pathology?
  • STUDY DESIGN: Spinal ependymoma is a benign central nervous system tumor described as an intramedullary lesion more frequently located at the conus medullaris.
  • It has been described exceptionally in the literature as an intradural extramedullary tumor.
  • SUMMARY OF BACKGROUND DATA: This case demonstrates an unusual location of a benign ependymal tumor in the extramedullary space with a total resection, which recurred in a lower level with a malignant transformation with the same extramedullary location.
  • METHODS: The authors present the case of a 47-year-old woman with a subacute spinal cord dysfunction and an intradural extramedullary D2-D3 tumor mimicking meningioma or neurinoma.
  • RESULTS: After complete resection, anatomic-pathologic studies confirmed that the lesion was a benign classic ependymoma.
  • Good neurologic outcome was achieved, and no residual tumor was present at magnetic resonance imaging (MRI) control performed at 3 and 9 months later.
  • One year after surgery, a new intradural extramedullary tumor was found at the D4 level without recurrence at D2.
  • CONCLUSION: All of the previously reported cases of spinal intradural extramedullary ependymomas carried out a benign course.
  • This tumor should be taken into account in the differential diagnosis of intradural extramedullary lesions.
  • [MeSH-major] Cell Transformation, Neoplastic / pathology. Dura Mater / pathology. Ependymoma / pathology. Spinal Neoplasms / pathology
  • [MeSH-minor] Combined Modality Therapy. Diagnosis, Differential. Female. Humans. Meningioma / diagnosis. Middle Aged. Neoplasms, Second Primary / pathology. Neoplasms, Second Primary / radiotherapy. Neoplasms, Second Primary / surgery. Neurilemmoma / diagnosis

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  • (PMID = 15864145.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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75. Wang EM, Pan L, Wang BJ, Zhang N, Dong YF, Dai JZ, Cai PW: [Gamma knife for elderly patients with large vestibular schwannomas: 11-year follow-up]. Zhonghua Yi Xue Za Zhi; 2009 May 5;89(17):1189-91
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  • [Title] [Gamma knife for elderly patients with large vestibular schwannomas: 11-year follow-up].
  • OBJECTIVE: To evaluate the effect of Leksell Gamma Knife (LGK) on elderly patients with large vestibular schwannomas (VS) and to summarize the indications for LGK in patients with large vs.
  • The maximal tumor diameter ranged from 31.0 to 61.0 mm [mean, (36.0 +/- 6.1) mm] and mean tumor volume was (14.8 +/- 8.0) cm(3) (range, 7.5 - 54.0 cm(3)).
  • The maximal dose irradiated to tumor ranged from 22.0 to 28.0 Gy [mean: (25.0 +/- 1.6) Gy] and the mean tumor marginal dose was (12.3 +/- 0.9) Gy (range, 9.5 - 14.0 Gy).
  • Two patients with giant VS died at 6 and 9 months post-LGK respectively because of tumor swelling.
  • Eighteen patients had deteriorated facial numbness because of tumor swelling, 15 of them improved 3 years later.
  • Tumor response: in 46 surviving patients, 43 tumors decreased markedly in size, 2 tumors remained stable in volume, 1 tumor progressed at five years and had second LGK.
  • In this series tumor control rate was 94% (47/50).
  • CONCLUSION: LGK provides an effective treatment for some selected large VS (maximal diameter <or= 40 mm) in elderly patients, especially when the brain stem compression was not obvious and VS had non-enhanced area or small cysts within the tumor on contrast MRI.

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  • (PMID = 19595084.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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76. Kilicoglu B, Kismet K, Gollu A, Sabuncuoglu MZ, Akkus MA, Serin-Kilicoglu S, Ustun H: Case report: mesenteric schwannoma. Adv Ther; 2006 Sep-Oct;23(5):696-700
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  • [Title] Case report: mesenteric schwannoma.
  • Schwannomas are benign neurogenic tumors that arise from Schwann cells that line the sheaths of peripheral nerves.
  • Schwannomas are commonly located in the soft tissues of the head and neck, extremities, mediastinum, retroperitoneum, and pelvis, but they are very rare in the mesentery.
  • Histopathologic and immunohistochemical examination revealed a mesenteric schwannoma.
  • Although schwannomas are very rare and generally asymptomatic, these tumors can become quite large and may cause acute abdominal problems such as mechanical bowel obstruction.
  • [MeSH-major] Mesentery. Neurilemmoma / diagnosis. Peritoneal Neoplasms / diagnosis

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  • (PMID = 17142203.001).
  • [ISSN] 0741-238X
  • [Journal-full-title] Advances in therapy
  • [ISO-abbreviation] Adv Ther
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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77. Saad AG, Mutema GK, Mutasim DF: Benign cutaneous epithelioid Schwannoma: case report and review of the literature. Am J Dermatopathol; 2005 Feb;27(1):45-7
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  • [Title] Benign cutaneous epithelioid Schwannoma: case report and review of the literature.
  • Benign peripheral nerve sheath tumors are relatively common.
  • Although variants with epithelioid foci can be present, the pure epithelioid variant of benign cutaneous schwannoma is extremely rare.
  • It was first reported as cutaneous epithelial schwannoma by Kindblom et al in 1998.
  • We report a case of cutaneous epithelioid schwannoma and review of the literature.
  • [MeSH-major] Epithelioid Cells / pathology. Neurilemmoma / pathology. Peripheral Nerves / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Female. Humans. Immunoenzyme Techniques. Middle Aged

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  • (PMID = 15677978.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 3
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78. Kaneko K, Kato Y, Kojima T, Imajyo Y, Taguchi T: Intraoperative electrophysiologic studies on the functions of nerve roots involved in cervical dumbbell-shaped schwannoma and their clinical utility. J Spinal Disord Tech; 2006 Dec;19(8):571-6
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  • [Title] Intraoperative electrophysiologic studies on the functions of nerve roots involved in cervical dumbbell-shaped schwannoma and their clinical utility.
  • BACKGROUND: It is difficult to expect the degree of neurologic deficits after resection of involved nerve roots before and during the surgery for cervical dumbbell-shaped schwannoma.
  • We present the results of studies for cervical nerve root functions in patients with cervical schwannoma using intraoperative electrophysiologic assessment and the potential of their clinical relevance is also discussed.
  • OBJECTIVE: To present the utility of intraoperative electrophysiologic studies to detect the functions of the nerve roots involved in cervical schwannoma and adjacent nerve roots.
  • METHODS: Five patients with dumbbell-shaped cervical schwannoma arising from the cervical nerve roots composing the brachial plexus were studied.
  • Compound muscle action potentials (CMAPs) after stimulation of nerve roots involved in the schwannoma were recorded from upper limb muscles anatomically correspond to their myotome.
  • RESULTS: In 4 patients, CMAPs after stimulation of cervical nerve roots involved with the schwannoma were not obtained or were very small compared with those obtained after stimulation of adjacent nerve roots.
  • In 2 of 4 patients, SNAPs after digital nerve stimulation were recorded with small amplitude from the nerve roots involved in schwannoma.
  • Minimal (n=2, within 80% attenuation of amplitude) or no changes (n=2) were observed after total resection of the schwannoma and no apparent motor weakness occurred in these 4 patients.
  • In a patient with cervical schwannoma involved in C8 nerve root, CMAPs with large amplitude were recorded after stimulation of the C8 nerve root.
  • Intradural parts of the tumor arising from C8 posterior rootlets were completely removed after transaction of posterior rootlets.
  • During removal of intraforaminal parts of the tumor, motor evoked potentials were decreased over 50% of controls.
  • CONCLUSIONS: The residual function of motor and sensory nerve roots involved with cervical schwannoma differed between individuals and could be detected using intraoperative electrophysiologic assessment.
  • [MeSH-major] Cervical Vertebrae. Neurilemmoma / physiopathology. Neurilemmoma / surgery. Spinal Neoplasms / physiopathology. Spinal Neoplasms / surgery. Spinal Nerve Roots / physiopathology

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  • (PMID = 17146300.001).
  • [ISSN] 1536-0652
  • [Journal-full-title] Journal of spinal disorders & techniques
  • [ISO-abbreviation] J Spinal Disord Tech
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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79. Chang LS, Welling DB: Molecular biology of vestibular schwannomas. Methods Mol Biol; 2009;493:163-77
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  • [Title] Molecular biology of vestibular schwannomas.
  • Recent advances in molecular biology have led to a better understanding of the etiology of vestibular schwannomas.
  • The underlying purpose of vestibular schwannoma research is the development of new treatment options; however, such options have not yet been established.
  • A fundamental understanding of the underlying molecular events leading to tumor formation began when mutations in the neurofibromatosis type 2 (NF2) tumor suppressor gene were identified in vestibular schwannomas.
  • The clinical characteristics of vestibular schwannomas and neurofibromatosis type 2 (NF2) syndromes have both been related to alterations in the NF2 gene.
  • When utilized with clinical screening, such as magnetic resonance imaging (MRI), conventional audiometry, and auditory brainstem response (ABR), the early detection of NF2 can be made, which consequently makes a significant difference in the ability to successfully treat vestibular schwannomas.
  • Nf2-transgenic and knockout mice as well as vestibular schwannoma xenograft models are now ready for novel therapeutic testing.
  • [MeSH-minor] Animals. DNA Mutational Analysis. Genetic Predisposition to Disease. Humans. Magnetic Resonance Imaging. Mice. Mice, Knockout. Mice, SCID. Mice, Transgenic. Neurofibromatosis 2 / genetics. Neurofibromatosis 2 / pathology

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  • (PMID = 18839347.001).
  • [ISSN] 1064-3745
  • [Journal-full-title] Methods in molecular biology (Clifton, N.J.)
  • [ISO-abbreviation] Methods Mol. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Neurofibromin 2
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80. Swensen JJ, Keyser J, Coffin CM, Biegel JA, Viskochil DH, Williams MS: Familial occurrence of schwannomas and malignant rhabdoid tumour associated with a duplication in SMARCB1. J Med Genet; 2009 Jan;46(1):68-72
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  • [Title] Familial occurrence of schwannomas and malignant rhabdoid tumour associated with a duplication in SMARCB1.
  • BACKGROUND: The role of germline and somatic SMARCB1 gene mutations in malignant rhabdoid tumour (MRT) predisposition is well known.
  • This duplication segregates with disease in individuals affected with both conditions, linking MRT predisposition and schwannomatosis as components of the same syndrome in this family.

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  • (PMID = 19124645.001).
  • [ISSN] 1468-6244
  • [Journal-full-title] Journal of medical genetics
  • [ISO-abbreviation] J. Med. Genet.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA046274-17A2; United States / NCI NIH HHS / CA / R01 CA046274; United States / NCI NIH HHS / CA / CA46274; United States / NCI NIH HHS / CA / R01 CA046274-17A2
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Chromosomal Proteins, Non-Histone; 0 / DNA-Binding Proteins; 0 / SMARCB1 protein, human; 0 / Transcription Factors
  • [Other-IDs] NLM/ NIHMS110136; NLM/ PMC2843150
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81. Levivier M: Tissue changes after radiosurgery for vestibular schwannomas. Prog Neurol Surg; 2008;21:98-102
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  • [Title] Tissue changes after radiosurgery for vestibular schwannomas.
  • The specific effects of radiosurgery on brain tumor tissue are not well understood.

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  • (PMID = 18810206.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 17
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82. Brandt MG, Poirier J, Hughes B, Lownie SP, Parnes LS: The transcrusal approach: a 10-year experience at one Canadian center. Neurosurgery; 2010 May;66(5):1017-22
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  • RESULTS: Operative indications included meningioma (5 patients), epidermoid/dermoid cyst (3 patients), trigeminal schwannoma (3 patients), giant or large upper basilar artery aneurysm (3 patients), pontine cavernoma (1 patient), chondrosarcoma (1 patient), and clival melanocytoma (1 patient).
  • Average tumor size was 3.6 cm.

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  • (PMID = 20414979.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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83. Elvsåshagen T, Solyga V, Bakke SJ, Heiberg A, Kerty E: [Neurofibromatosis type 2 and auditory brainstem implantation]. Tidsskr Nor Laegeforen; 2009 Aug 13;129(15):1469-73
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  • BACKGROUND: Neurofibromatosis type 2 (NF2) is a rare and severe autosomal dominant disorder caused by mutations in a tumour suppressor gene.
  • MATERIAL AND METHODS: The review is based on the authors' experience with the disease and literature identified through a non-systematic search of PubMed.
  • RESULTS: NF2 is caused by loss-of-normal function of the tumour suppressor protein merlin.
  • Merlin normally suppresses cell growth and proliferation.
  • The clinical picture is dominated by neurological symptoms, caused by multiple tumours - mainly schwannomas and meningeomas.
  • The hallmark of the disease is development of bilateral vestibular schwannomas, and the most common presenting symptom in adults is progressive hearing loss.
  • Emerging knowledge of the molecular disease mechanisms offers hope for new therapeutic strategies.
  • [MeSH-minor] Adult. Child. Deafness / rehabilitation. Deafness / surgery. Humans. Magnetic Resonance Imaging. Neurilemmoma / pathology. Neurilemmoma / surgery. Quality of Life. Spinal Neoplasms / pathology. Spinal Neoplasms / surgery. Treatment Outcome

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  • (PMID = 19690597.001).
  • [ISSN] 0807-7096
  • [Journal-full-title] Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række
  • [ISO-abbreviation] Tidsskr. Nor. Laegeforen.
  • [Language] nor
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Norway
  • [Number-of-references] 25
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84. Wang KL, Weinrach DM, Luan C, Han M, Lin F, Teh BT, Yang XJ: Renal papillary adenoma--a putative precursor of papillary renal cell carcinoma. Hum Pathol; 2007 Feb;38(2):239-46
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  • [Title] Renal papillary adenoma--a putative precursor of papillary renal cell carcinoma.
  • The precursor lesions of renal cell carcinoma (RCC) are unknown.
  • Immunohistochemistry was carried out with antibodies specific for alpha-methyl-coenzyme A racemase (AMACR) and glutathione S-transferase alpha (clear-cell RCC marker).
  • Seven papillary adenomas (18%) occurred in the setting of acquired polycystic kidney disease (APKD), 6 in clear-cell RCCs, 3 in chromophobe RCCs, 2 in end-stage kidney disease, 1 in oncocytoma, 1 in angiomyolipoma, and 1 in renal schwannoma.
  • Furthermore, papillary adenomas were more commonly found in kidneys removed for PRCC (25%, 18/71) than in kidneys harboring clear-cell RCC (1.9%, 6/318).
  • [MeSH-major] Carcinoma, Papillary / pathology. Carcinoma, Renal Cell / pathology. Kidney Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma, Clear Cell / enzymology. Adenocarcinoma, Clear Cell / pathology. Adenoma. Adenoma, Oxyphilic / enzymology. Adenoma, Oxyphilic / pathology. Adult. Aged. Aged, 80 and over. Angiomyolipoma / enzymology. Angiomyolipoma / pathology. Disease Progression. Female. Glutathione Transferase / analysis. Humans. Immunohistochemistry. Isoenzymes / analysis. Kidney / enzymology. Kidney / pathology. Kidney Failure, Chronic / enzymology. Kidney Failure, Chronic / pathology. Male. Middle Aged. Models, Biological. Polycystic Kidney Diseases / enzymology. Polycystic Kidney Diseases / pathology. Racemases and Epimerases / analysis

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  • (PMID = 17056094.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Isoenzymes; EC 2.5.1.18 / Glutathione Transferase; EC 2.5.1.18 / glutathione S-transferase alpha; EC 5.1.- / Racemases and Epimerases; EC 5.1.99.4 / alpha-methylacyl-CoA racemase
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85. Feucht M, Richard G, Mautner VF: Neurofibromatosis 2 leads to choroidal hyperfluorescence in fluorescein angiography. Graefes Arch Clin Exp Ophthalmol; 2007 Jul;245(7):949-53
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  • An early diagnosis is essential in order to inhibit deafness from bilateral vestibular schwannoma.
  • The ophthalmic examination, which often is limited to the anterior eye segment, may play a role in finding the diagnosis in incomplete NIH criteria.

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  • (PMID = 17186263.001).
  • [ISSN] 0721-832X
  • [Journal-full-title] Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
  • [ISO-abbreviation] Graefes Arch. Clin. Exp. Ophthalmol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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86. Hussein HA, Goda HA: Paravertebral neurogenic tumors with intraspinal extension: preoperative evaluation and surgical approach. J Egypt Natl Canc Inst; 2009 Mar;21(1):12-22
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  • All patients had CT with guided biopsy and MRI to evaluate extent of tumor bone invasion, intraspinal component, to decide surgical approach and the need for spine fixation.
  • Benign schwannoma were diagnosed in 5 cases, malignant schwannoma in 3, neurofibromatosis in one case, neuroblastoma in 3 cases, ganglioneuroblastoma in 2 cases and ganglioneuroma in 2 cases.
  • Delivery of the tumor was done in 8 cases, widening of the intervertebral foramina in 3 cases, costotransversectomy with lateral laminectomy in 3 cases while posterior laminectomy and total vertebrectomy was done in one case.

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  • (PMID = 20601967.001).
  • [ISSN] 1110-0362
  • [Journal-full-title] Journal of the Egyptian National Cancer Institute
  • [ISO-abbreviation] J Egypt Natl Canc Inst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
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87. Ozkan EE, Guldur ME, Uzunkoy A: A case report of benign schwannoma of the liver. Intern Med; 2010;49(15):1533-6
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  • [Title] A case report of benign schwannoma of the liver.
  • Benign schwannoma is a very rare confronted entity in the liver.
  • The histological examination confirmed the diagnosis of a benign schwannoma, proven by verocay bodies and a positive immunoreaction with the neurogenic marker S-100 protein.
  • [MeSH-major] Liver Neoplasms / diagnosis. Liver Neoplasms / surgery. Neurilemmoma / diagnosis. Neurilemmoma / surgery


88. Karaman E, Yilmaz S, Ozçora E, Ozek H, Korkut N, Sar M: Schwannoma of the lateral nasal wall: two case reports and review of the literature. J Otolaryngol; 2007 Jun;36(3):E1-4
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  • [Title] Schwannoma of the lateral nasal wall: two case reports and review of the literature.
  • [MeSH-major] Neurilemmoma / surgery. Nose Neoplasms / surgery

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  • (PMID = 17711753.001).
  • [ISSN] 0707-7270
  • [Journal-full-title] The Journal of otolaryngology
  • [ISO-abbreviation] J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Canada
  • [Number-of-references] 13
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89. Rausche T, El-Mokthari NE, Krüger D, Herrman G, Tiroke A, Rahimi-Barfeh A, Lins M: Benign mediastinal schwannoma: cardiac considerations - case report and a short review of the literature. Clin Res Cardiol; 2006 Aug;95(8):422-4
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  • [Title] Benign mediastinal schwannoma: cardiac considerations - case report and a short review of the literature.
  • [MeSH-major] Mediastinal Neoplasms / diagnosis. Neurilemmoma / diagnosis

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  • [Cites] Cardiovasc Pathol. 2003 Sep-Oct;12(5):290-2 [14507580.001]
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  • (PMID = 16741628.001).
  • [ISSN] 1861-0684
  • [Journal-full-title] Clinical research in cardiology : official journal of the German Cardiac Society
  • [ISO-abbreviation] Clin Res Cardiol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Germany
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90. Slattery WH, Lev MH, Fisher LM, Connell SS, Iqbal Z, Go JL, NF2 Natural History Consortium: MRI evaluation of neurofibromatosis 2 patients: a standardized approach for accuracy in interpretation. Otol Neurotol; 2005 Jul;26(4):733-40
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  • OBJECTIVE: To determine the level of agreement between local radiologists' and an experienced neuroradiologist's measurements of vestibular schwannomas.
  • MAIN OUTCOME MEASURES: Spearman's rho interobserver association coefficient of vestibular schwannoma linear measurements.
  • If the schwannoma was difficult to assess, because of magnetic resonance imaging acquisition protocol, postoperative changes, or tumors smaller than 5 mm in greatest diameter, the neuroradiologist provided a more thorough assessment.
  • The authors suggest uniform reporting criteria for vestibular schwannoma assessments to ensure clinically relevant information is communicated regarding vestibular schwannoma size.

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  • (PMID = 16015177.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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91. Yomo S, Arkha Y, Delsanti C, Roche PH, Thomassin JM, Régis J: Repeat gamma knife surgery for regrowth of vestibular schwannomas. Neurosurgery; 2009 Jan;64(1):48-54; discussion 54-5
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  • [Title] Repeat gamma knife surgery for regrowth of vestibular schwannomas.
  • OBJECTIVE: Gamma knife surgery (GKS) has become established as a minimally invasive treatment modality for patients with vestibular schwannomas.
  • Treatment failure and/or tumor regrowth, however, is occasionally encountered, and microsurgical resection is usually warranted in such cases.
  • The goal of this study was to investigate whether repeat GKS is an effective treatment for recurrent vestibular schwannomas and to assess the conservation of residual neurological function.
  • METHODS: Between July 1992 and December 2007, 1951 patients harboring a unilateral vestibular schwannoma were treated with GKS.
  • Of these, 48 patients (2.5%) had to undergo a subsequent intervention because of progression or regrowth of the tumor.
  • The median tumor volume was 0.51 and 1.28 mL at the initial and second GKS treatments, respectively.
  • Six patients demonstrated a significant reduction in tumor volume.
  • In 1 patient, the final tumor volume was less than the initial volume.
  • The other 2 patients showed stabilization of tumor growth.
  • Useful hearing ability was preserved in only 1 of the 3 patients who had serviceable hearing ability at the time of the second GKS.
  • CONCLUSION: This is the first report to address repeat GKS for vestibular schwannomas.
  • After long-term follow-up, repeat GKS with a low marginal dose seems to be a safe and effective treatment in selected patients harboring regrowth of small vestibular schwannomas that have previously been treated with GKS.

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  • (PMID = 19050660.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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92. Desantis SM, Houseman EA, Coull BA, Stemmer-Rachamimov A, Betensky RA: A penalized latent class model for ordinal data. Biostatistics; 2008 Apr;9(2):249-62
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  • We illustrate our methodology in a study of schwannoma, a peripheral nerve sheath tumor, that included 3 clinical subtypes and 23 ordinal histological measures.

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  • (PMID = 17626225.001).
  • [ISSN] 1465-4644
  • [Journal-full-title] Biostatistics (Oxford, England)
  • [ISO-abbreviation] Biostatistics
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA075971; United States / NCI NIH HHS / CA / CA075971; United States / NINDS NIH HHS / NS / P01NS24279-18
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ NIHMS478937; NLM/ PMC4878392
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93. Halefoğlu AM: Neurofibromatosis type 2 associated with multiple cranial nerve schwannomas: a case report. Kulak Burun Bogaz Ihtis Derg; 2007;17(3):171-5
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  • [Title] Neurofibromatosis type 2 associated with multiple cranial nerve schwannomas: a case report.
  • He also had a family history of neurofibromatosis type 2 and a history of a prior operation for left vestibular schwannoma a year ago.
  • These findings were evaluated as multiple cranial nerve schwannomas.
  • The case was considered a rare manifestation of neurofibromatosis type 2 without any concomitant abnormality in the central nervous system.
  • [MeSH-major] Cochlear Nerve. Cranial Nerve Neoplasms / diagnosis. Neurilemmoma / diagnosis. Neurofibromatosis 2 / diagnosis

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  • (PMID = 17873509.001).
  • [ISSN] 1300-7475
  • [Journal-full-title] Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
  • [ISO-abbreviation] Kulak Burun Bogaz Ihtis Derg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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94. Ahmad Z, Brown CM, Patel AK, Ryan AF, Ongkeko R, Doherty JK: Merlin knockdown in human Schwann cells: clues to vestibular schwannoma tumorigenesis. Otol Neurotol; 2010 Apr;31(3):460-6
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  • [Title] Merlin knockdown in human Schwann cells: clues to vestibular schwannoma tumorigenesis.
  • HYPOTHESIS: To investigate the early events in molecular progression toward schwannoma tumorigenesis, we developed an in vitro model of human Schwann cell tumorigenesis by merlin knockdown.
  • BACKGROUND: Neurofibromatosis 2 (NF2)-related and sporadic vestibular schwannoma (VS) exhibit loss of functional merlin (schwannomin).
  • After loss of merlin expression in the Schwann cell, the initial steps toward VS tumorigenesis are unknown.
  • Merlin, a putative tumor suppressor protein, interacts with many cellular proteins, regulating their function.
  • Deregulation of CD44, the cell adhesion/signaling molecule and cancer stem cell marker, has also been implicated in VS tumorigenesis.
  • METHODS: Merlin knockdown was performed using small interfering RNA transfection into human Schwann cell primary cultures.
  • Expression profiles of ErbB, merlin, and the stem cell markers nestin and CD44 were examined in knockdowns.
  • CONCLUSION: Merlin depletion results in deregulation of ErbB receptor signaling, promotes a dedifferentiated state, and increases Schwann cell proliferation, suggesting critical steps toward schwannoma tumorigenesis.

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  • (PMID = 20195187.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] ENG
  • [Grant] United States / BLRD VA / BX / I01 BX001205; United States / NIDCD NIH HHS / DC / 5 K08 DC008523-01A1; United States / NIDCD NIH HHS / DC / K08 DC008523; United States / NIDCD NIH HHS / DC / K08 DC008523-03; United States / NIDCD NIH HHS / DC / T32 DC000028; United States / NIDCD NIH HHS / DC / DC008523-03
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD44; 0 / Intermediate Filament Proteins; 0 / NES protein, human; 0 / Nerve Tissue Proteins; 0 / Nestin; 0 / Neurofibromin 2; 0 / RNA, Small Interfering; EC 2.7.10.1 / EGFR protein, human; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
  • [Other-IDs] NLM/ NIHMS198738; NLM/ PMC2873969
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95. Mahore A, Chagla A, Goel A: Giant ventral midline schwannoma of cervical spine : agonies and nuances. J Korean Neurosurg Soc; 2010 Jun;47(6):454-7
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  • [Title] Giant ventral midline schwannoma of cervical spine : agonies and nuances.
  • Pure ventral midline giant schwannoma is an extremely rare entity.
  • Spinal intradural extramedullary schwannomas commonly occur posterolateral or anterolateral to the spinal cord.
  • A case of a pure midline ventrally situated giant pan cervical extramedullary schwannoma in an 18-year-old male patient with compressive myelopathy and sphincter involvement is presented.
  • Spinal MR imaging showed a midline ventrally situated extramedullary tumor with severe spinal cord compression extending from clivus to C7 vertebra.
  • Histology was consistent with a schwannoma.
  • Post operative MR imaging showed no evidence of the tumor.

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  • (PMID = 20617092.001).
  • [ISSN] 1598-7876
  • [Journal-full-title] Journal of Korean Neurosurgical Society
  • [ISO-abbreviation] J Korean Neurosurg Soc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2899034
  • [Keywords] NOTNLM ; Extramedullary / Giant schwannoma / Intradural / Spine / Ventral location
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96. Chiofalo MG, Longo F, Marone U, Franco R, Petrillo A, Pezzullo L: Cervical vagal schwannoma. A case report. Acta Otorhinolaryngol Ital; 2009 Feb;29(1):33-5
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  • [Title] Cervical vagal schwannoma. A case report.
  • Schwannoma originating from the cervical vagus nerve is an extremely rare neoplasm.
  • Vagal nerve schwannoma usually occurs between the third and fifth decades of life, it does not show sex predilection both sexes being equally affected and it most often presents as a painless, slow-growing, lateral neck mass.
  • These tumours, in fact, are almost always benign and a conservative surgical approach is emphasized by most of the Authors.
  • A case of a cervical vagal schwannoma, in a 33-year old male with a previous medical history of malignant lymphoma, is described.
  • The clinical features, diagnosis, management and pathological findings of cervical vagal schwannoma are discussed.
  • [MeSH-major] Cranial Nerve Neoplasms. Neurilemmoma. Vagus Nerve Diseases

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  • (PMID = 19609380.001).
  • [ISSN] 1827-675X
  • [Journal-full-title] Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale
  • [ISO-abbreviation] Acta Otorhinolaryngol Ital
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2689565
  • [Keywords] NOTNLM ; Benign tumours / Magnetic Resonance imaging / Schwannoma / Vagus nerve
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97. Stark AM, Maslehaty H, Hugo HH, Mahvash M, Mehdorn HM: Glioblastoma of the cerebellum and brainstem. J Clin Neurosci; 2010 Oct;17(10):1248-51
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  • Glioblastoma multiforme (GB) is the most common and most malignant primary intracranial tumor.
  • Of the 577 patients who underwent surgery for newly diagnosed GB (World Health Organization grade IV) between January 1991 and March 2008 at our department, seven had infratentorial GB (iGB) (incidence 1.2%).
  • Because of its rarity and the non-specific radiological features of iGB, it can easily be misdiagnosed as a brain metastasis, ependymoma or even as a benign lesion such as vestibular schwannoma or meningioma.

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  • [Copyright] Copyright 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20619657.001).
  • [ISSN] 1532-2653
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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98. Beschorner R, Mittelbronn M, Koerbel A, Ernemann U, Thal DR, Scheel-Walter HG, Meyermann R, Tatagiba M: Atypical teratoid-rhabdoid tumor spreading along the trigeminal nerve. Pediatr Neurosurg; 2006;42(4):258-63
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  • [Title] Atypical teratoid-rhabdoid tumor spreading along the trigeminal nerve.
  • We here describe the case of a boy with an atypical teratoid-rhabdoid tumor (ATRT) of the 4th ventricle at 1 year of age and a local tumor recurrence at 19 months of age.
  • Due to brainstem infiltration, only incomplete tumor resection was possible each time.
  • High-dose chemotherapy, stem cell transplantation and irradiation resulted in complete tumor remission on a control MRI.
  • At 8 years of age, another tumor appeared extending from the cerebellopontine angle along the right trigeminal nerve through Meckel's cave into the cavernous sinus.
  • The trigeminal tumor was not in continuity with the primary ATRT but was located within the field of prior irradiation, neuroradiologically mimicking a schwannoma or a meningioma.
  • The origin of the trigeminal tumor as a late metastasis of the former ATRT or as a less likely irradiation-induced secondary ATRT and the operative approach are discussed.
  • [MeSH-major] Brain Neoplasms / diagnosis. Cranial Nerve Neoplasms / diagnosis. Rhabdoid Tumor / diagnosis. Teratoma / diagnosis. Trigeminal Nerve Diseases / diagnosis
  • [MeSH-minor] Chemotherapy, Adjuvant. Child. Fourth Ventricle / pathology. Humans. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local / therapy. Stem Cell Transplantation

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  • [Copyright] Copyright (c) 2006 S. Karger AG, Basel.
  • (PMID = 16714870.001).
  • [ISSN] 1016-2291
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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99. Sun JQ, Han DM, Li YX, Gong SS, Zan HR, Wang T: Combined endoscope-assisted translabyrinthine subtemporal keyhole approach for vestibular Schwannoma and auditory midbrain implantation: Cadaveric study. Acta Otolaryngol; 2010 Oct;130(10):1125-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Combined endoscope-assisted translabyrinthine subtemporal keyhole approach for vestibular Schwannoma and auditory midbrain implantation: Cadaveric study.
  • As a minimally invasive approach, this can be considered an effective method for removal of vestibular schwannoma and auditory midbrain implantation in the same surgical setting, while avoiding retraction of the cerebellum and serious adverse events and complications.
  • OBJECTIVES: Patients with neurofibromatosis type II are the initial candidates for auditory midbrain implantation; the appropriate surgical approach should allow for tumor removal and electrode implantation in the same surgical setting.

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  • (PMID = 20367538.001).
  • [ISSN] 1651-2251
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
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100. Jacob A, Robinson LL Jr, Bortman JS, Yu L, Dodson EE, Welling DB: Nerve of origin, tumor size, hearing preservation, and facial nerve outcomes in 359 vestibular schwannoma resections at a tertiary care academic center. Laryngoscope; 2007 Dec;117(12):2087-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nerve of origin, tumor size, hearing preservation, and facial nerve outcomes in 359 vestibular schwannoma resections at a tertiary care academic center.
  • OBJECTIVE: To determine nerve of origin, tumor size, hearing preservation rates, and facial nerve outcomes in a retrospective cohort study of patients undergoing translabyrinthine (TL), middle cranial fossa (MCF), and retrosigmoid/suboccipital (SO) approaches to vestibular schwannomas (VS).
  • Seventy-one of 74 patients (95%) patients with IVN tumors achieved a House-Brackmann (HB) grade I-III, while 35 of 35 patients (100%) with SVN tumors retained HB I-III facial function.
  • Looking at tumor size versus hearing preservation, functional hearing was preserved in 22 of 49 patients (45%) with <1-cm tumors, and 4 of 20 patients (20%) with 1- to 1.5-cm tumors.

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  • (PMID = 17921903.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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