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1. Larsson K, Kåreholt I, Thorslund M: Care utilisation in the last years of life in relation to age and time to death: results from a Swedish urban population of the oldest old. Eur J Ageing; 2008 Dec;5(4):349-357

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  • The proportion residing in institutional care facilities with around-the-clock care increased steadily with a sharper gradient 6 months before death.

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  • (PMID = 28798585.001).
  • [ISSN] 1613-9372
  • [Journal-full-title] European journal of ageing
  • [ISO-abbreviation] Eur J Ageing
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Keywords] NOTNLM ; End-of-life care / Hospitalisation / Institutionalisation / Swedish elder care
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2. Kania ML, Meyer BB, Ebersole KT: Personal and environmental characteristics predicting burnout among certified athletic trainers at National Collegiate Athletic Association institutions. J Athl Train; 2009 Jan-Feb;44(1):58-66
MedlinePlus Health Information. consumer health - Stress.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Personal and environmental characteristics predicting burnout among certified athletic trainers at National Collegiate Athletic Association institutions.
  • OBJECTIVE: To examine the relationship between selected personal and environmental characteristics and burnout among certified athletic trainers (ATs).
  • PATIENTS OR OTHER PARTICIPANTS: A total of 206 ATs employed at National Collegiate Athletic Association (NCAA) institutions as clinical ATs volunteered.
  • The results also support the Cognitive-Affective Model of Athletic Burnout proposed by Smith.

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  • (PMID = 19180220.001).
  • [ISSN] 1938-162X
  • [Journal-full-title] Journal of athletic training
  • [ISO-abbreviation] J Athl Train
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2629041
  • [Keywords] NOTNLM ; professional development / work pressure / work stress
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3. Groth JJ, Ayers SF, Miller MG, Arbogast WD: Self-reported health and fitness habits of certified athletic trainers. J Athl Train; 2008 Oct-Dec;43(6):617-23
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Self-reported health and fitness habits of certified athletic trainers.
  • CONTEXT: As health care providers, certified athletic trainers (ATs) should be role models for healthy behaviors.

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  • (PMID = 19030140.001).
  • [ISSN] 1938-162X
  • [Journal-full-title] Journal of athletic training
  • [ISO-abbreviation] J Athl Train
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2582554
  • [Keywords] NOTNLM ; exercise / nutrition / role models
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4. Tollier C, Fusier I, Husson MC: [ATC and EphMRA classifications: evolution from 1996 to 2003 and comparative analysis]. Therapie; 2005 Jan-Feb;60(1):47-56
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  • [Title] [ATC and EphMRA classifications: evolution from 1996 to 2003 and comparative analysis].
  • [Transliterated title] Classifications ATC et EphMRA: evolution entre 1996 et 2003 et analyse comparative.
  • The "Hospital National Center of Drugs Information" (CNHIM) has integrated ATC (Anatomical Therapeutic Chemical) and EphMRA (European Pharmaceutical Marketing Research Association) classifications into its "Thériaque" database and has given the ATC official status in France by publishing a French translation.
  • The objective of this article was to analyse the evolution of these two classification systems between 1996 and 2003, and to compare their allocations (of codes) with those for the drugs present in Thériaque in January 2002.
  • The ATC comprises 14 principal groups and five levels of hierarchy, while the EphMRA comprises 16 principal groups and three to four levels.
  • In Thériaque, the ATC is linked to active substances and drugs, and the EphMRA to drugs.
  • Each year, the two classification systems evolve in terms of addition, suppression, modification and subdivision.
  • Two principal differences are evident in the allocations in Thériaque (class EphMRA K "Hospital solutions" versus class ATC B "Blood and blood forming organ"; class EphMRA T "Diagnostic agents" versus class ATC V "Various").
  • [MeSH-major] Drug Information Services / trends. Pharmaceutical Preparations / classification

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  • (PMID = 15929473.001).
  • [ISSN] 0040-5957
  • [Journal-full-title] Thérapie
  • [ISO-abbreviation] Therapie
  • [Language] fre
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Pharmaceutical Preparations
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5. John U, Baumeister SE, Völzke H, Grabe HJ, Freyberger HJ, Alte D: Estimation of psycholeptic and psychoanaleptic medicine use in an adult general population sample using the Anatomical Therapeutic Chemical classification. Int J Methods Psychiatr Res; 2008;17(4):220-31
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  • [Title] Estimation of psycholeptic and psychoanaleptic medicine use in an adult general population sample using the Anatomical Therapeutic Chemical classification.
  • Medicines taken during the past seven days were assessed from the medicine packages or self-reports and classified according to the Anatomical Therapeutic Chemical (ATC) classification developed by the World Health Organization.
  • It is concluded that considerable proportions of individuals with current PM use exist although lower than may be expected on the basis of the number of individuals with mental disorder in the general population.
  • [MeSH-major] Central Nervous System Stimulants / therapeutic use. Mass Screening / statistics & numerical data. Psychotropic Drugs / therapeutic use

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  • (PMID = 18792082.001).
  • [ISSN] 1049-8931
  • [Journal-full-title] International journal of methods in psychiatric research
  • [ISO-abbreviation] Int J Methods Psychiatr Res
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Central Nervous System Stimulants; 0 / Psychotropic Drugs
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6. Mensch J, Crews C, Mitchell M: Competing perspectives during organizational socialization on the role of certified athletic trainers in high school settings. J Athl Train; 2005 Oct-Dec;40(4):333-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Competing perspectives during organizational socialization on the role of certified athletic trainers in high school settings.
  • CONTEXT: When certified athletic trainers (ATCs) enter a workplace, their potential for professional effectiveness is affected by a number of factors, including the individual's ability to put acquired knowledge, skills, and attitudes into practice.
  • This ability may be influenced by the preconceived attitudes and expectations of athletes, athletes' parents, athletic directors, physical therapists, physicians, and coaches.
  • OBJECTIVE: To examine the perspectives of high school coaches and ATCs toward the ATC's role in the high school setting by looking at 3 questions:.
  • (1) the athletic training services they received as high school basketball coaches, (2) each coach's expectations of the ATC with whom he or she was working during various phases of the season, and (3) coaches' levels of satisfaction with the athletic training services provided to their team.
  • (1) the ATC's background, (2) the ATC's perceived duties at different phases of the basketball season and his or her relationship with the coach, and (3) other school factors that enhanced or interfered with the ATC's ability to perform duties.
  • Positive communication was identified as a critical component to a good coach-ATC relationship.
  • Coaches must be educated by ATCs to ensure they are receiving qualified athletic training support.

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  • (PMID = 16404456.001).
  • [ISSN] 1062-6050
  • [Journal-full-title] Journal of athletic training
  • [ISO-abbreviation] J Athl Train
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1323296
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7. Figueroa-Casas JB, Montoya R, Arzabala A, Connery SM: Comparison between automatic tube compensation and continuous positive airway pressure during spontaneous breathing trials. Respir Care; 2010 May;55(5):549-54
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  • [Title] Comparison between automatic tube compensation and continuous positive airway pressure during spontaneous breathing trials.
  • Automatic tube compensation (ATC) is a new and potentially advantageous ventilation mode to use during SBT.
  • We compared ATC to continuous positive airway pressure (CPAP) during SBTs, to determine their efficacy in identifying patients ready to be liberated from mechanical ventilation.
  • METHODS: We randomized 118 adults in a general intensive care unit on mechanical ventilation for > or = 24 h who were about to undergo an SBT as part of an established respiratory-therapist-driven weaning protocol to undergo 30 min SBT with ATC or CPAP with no pressure support.
  • RESULTS: We found a trend toward less failure of first SBT with ATC, compared to CPAP (3% vs 13% respectively, P = .09), but no difference in duration of weaning, rate of unsuccessful extubation, or duration of mechanical ventilation.
  • CONCLUSIONS: When applied as part of a respiratory-therapist-driven weaning protocol in a general intensive-care population, SBTs with ATC were safe but did not hasten liberation from mechanical ventilation, when compared to CPAP.

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  • [CommentIn] Respir Care. 2010 May;55(5):640-2 [20420738.001]
  • (PMID = 20420724.001).
  • [ISSN] 0020-1324
  • [Journal-full-title] Respiratory care
  • [ISO-abbreviation] Respir Care
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
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8. Schiff MA, Mack CD, Polissar NL, Levy MR, Dow SP, O'Kane JW: Soccer injuries in female youth players: comparison of injury surveillance by certified athletic trainers and internet. J Athl Train; 2010 May-Jun;45(3):238-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Soccer injuries in female youth players: comparison of injury surveillance by certified athletic trainers and internet.
  • OBJECTIVE: To determine whether certified athletic trainers (ATs) and parental, Internet-based surveys provided comparable data for identifying soccer injuries.
  • MAIN OUTCOME MEASURE(S): We compared the data provided by ATs attending 1 soccer practice per week with a weekly soccer-parent, Internet-based system.
  • Players sustained 17 overuse injuries (35% knee, 29% lower leg) reported by either system, with 35% reported by ATs and 100% by Internet-based survey.

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  • (PMID = 20446836.001).
  • [ISSN] 1938-162X
  • [Journal-full-title] Journal of athletic training
  • [ISO-abbreviation] J Athl Train
  • [Language] ENG
  • [Grant] United States / NIAMS NIH HHS / AR / R21 AR053371; United States / NIAMS NIH HHS / AR / R21AR053371
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2865961
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9. Tazbir J, Dedecjus M, Kaurzel Z, Lewiński A, Brzeziński J: Selective embolization of thyroid arteries (SETA) as a palliative treatment of inoperable anaplastic thyroid carcinoma (ATC). Neuro Endocrinol Lett; 2005 Aug;26(4):401-6
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  • [Title] Selective embolization of thyroid arteries (SETA) as a palliative treatment of inoperable anaplastic thyroid carcinoma (ATC).
  • OBJECTIVES: Anaplastic thyroid carcinoma (ATC) is one of the most aggressive solid tumors in humans.
  • Despite intense application of multimodality of treatment with surgery and/or external beam radiotherapy and chemotherapy, the survival rates remain low--generally the mean survival is about six (6) months after diagnosis.
  • Rapid development--particularly over the last decade--of interventional radiology, provides methodology that allows examining thyroid arterial embolization as an alternative approach to ablating thyroid tissue.
  • The aim of the present study was to evaluate selective embolization of the thyroid arteries (SETA) as a possible alternative for the palliative treatment of advanced, inoperable ATC.
  • PATIENTS AND METHODS: The study group comprised five (5) patients with advanced stage of inoperable ATC.
  • All the patients underwent SETA of the superior and/or inferior thyroid arteries.
  • After SETA, selective angiography of thyroid arteries was performed to ensure that the targeted arteries were completely occluded.
  • CONCLUSIONS: The results of the present study suggest that SETA is minimally invasive and save method of palliative treatment of ATC and, as such, may be recommended in cases of intractable hemorrhage and pain caused by ATC progression.
  • [MeSH-major] Carcinoma / therapy. Embolization, Therapeutic / methods. Palliative Care. Thyroid Gland / blood supply. Thyroid Neoplasms / therapy

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  • (PMID = 16136001.001).
  • [ISSN] 0172-780X
  • [Journal-full-title] Neuro endocrinology letters
  • [ISO-abbreviation] Neuro Endocrinol. Lett.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Sweden
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10. Glover L: Certified athletic trainers. Minn Med; 2010 Dec;93(12):43-5
MedlinePlus Health Information. consumer health - Sports Injuries.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Certified athletic trainers.
  • Certified athletic trainers optimize people's ability to participate in athletics or activities of work and life.
  • Athletic training encompasses the prevention, examination and assessment, treatment, and rehabilitation of emergent, acute, subacute, and chronic neuromusculoskeletal conditions.
  • Certified athletic trainers play a key role in health care delivery today, and that role is expected to evolve and grow in the future.
  • This article describes what certified athletic trainers do, outlines their educational and certification requirements, and describes the ways they work in different settings-from the sidelines to industry to medical clinics.
  • [MeSH-major] Athletic Injuries / prevention & control. Athletic Injuries / rehabilitation. Certification. Physical Education and Training

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  • (PMID = 21265420.001).
  • [ISSN] 0026-556X
  • [Journal-full-title] Minnesota medicine
  • [ISO-abbreviation] Minn Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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11. Roche B, Larroumets G, Dejax C, Kwiatkowsi F, Desbiez F, Thieblot P, Tauveron I: Epidemiology, clinical presentation, treatment and prognosis of a regional series of 26 anaplastic thyroid carcinomas (ATC). Comparison with the literature. Ann Endocrinol (Paris); 2010 Feb;71(1):38-45
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epidemiology, clinical presentation, treatment and prognosis of a regional series of 26 anaplastic thyroid carcinomas (ATC). Comparison with the literature.
  • OBJECTIVE: The aim of this study is to retrospectively describe the epidemiological and clinical features, therapeutic modalities, prognostic factors and survival figures in a population of patients with anaplastic thyroid carcinoma (ATC) observed in Auvergne, France.
  • MATERIAL AND METHODS: The analysis was conducted based on a computer database containing a regional register recorded by health professionals treating ATC.
  • RESULTS: Of the 1500 cancers observed over 16 years, 26 were identified as ATC.
  • The male/female ratio was 1/2.7 and the average age: 72.1; 76.9% of the cases had thyroid medical history, average tumor size at diagnosis was 7.35 cm with N1 in the course of illness in 61.5% of cases, M1 in 34.6% of cases.
  • [MeSH-major] Carcinoma / therapy. Thyroid Neoplasms / therapy

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  • [Copyright] Copyright (c) 2009 Elsevier Masson SAS. All rights reserved.
  • (PMID = 19959159.001).
  • [ISSN] 0003-4266
  • [Journal-full-title] Annales d'endocrinologie
  • [ISO-abbreviation] Ann. Endocrinol. (Paris)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] France
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12. Laco J, Ryska A, Celakovský P: [Anaplastic carcinoma of the thyroid gland with chondrosarcomatous component]. Cesk Patol; 2005 Jan;41(1):34-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Anaplastic carcinoma of the thyroid gland with chondrosarcomatous component].
  • [Transliterated title] Anaplastický karcinom stítné zlázy s chondrosarkomatózní komponentou.
  • Fine needle aspiration cytology was performed with the conclusion of a sarcomatoid variant of anaplastic carcinoma of the thyroid gland; biopsy was recommended.
  • The diagnosis of thyroid anaplastic carcinoma with chondrosarcomatous component was established.
  • [MeSH-major] Carcinoma / pathology. Chondrosarcoma / pathology. Thyroid Neoplasms / pathology

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  • (PMID = 15816122.001).
  • [ISSN] 1210-7875
  • [Journal-full-title] Československá patologie
  • [ISO-abbreviation] Cesk Patol
  • [Language] cze
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Czech Republic
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13. Fothergill S, Loft S, Neal A: ATC-lab(Advanced): an air traffic control simulator with realism and control. Behav Res Methods; 2009 Feb;41(1):118-127
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  • [Title] ATC-lab(Advanced): an air traffic control simulator with realism and control.
  • ATC-lab(Advanced) is a new, publicly available air traffic control (ATC) simulation package that provides both realism and experimental control.
  • ATC-lab(Advanced) simulations are realistic to the extent that the display features (including aircraft performance) and the manner in which participants interact with the system are similar to those used in an operational environment.
  • Experimental control allows researchers to standardize air traffic scenarios, control levels of realism, and isolate specific ATC tasks.
  • Importantly, ATC-lab(Advanced) also provides the programming control required to cost effectively adapt simulations to serve different research purposes without the need for technical support.
  • In addition, ATC-lab(Advanced) includes a package for training participants and mathematical spreadsheets for designing air traffic events.
  • Preliminary studies have demonstrated that ATC-lab(Advanced) is a flexible tool for applied and basic research.

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  • (PMID = 19182131.001).
  • [ISSN] 1554-351X
  • [Journal-full-title] Behavior research methods
  • [ISO-abbreviation] Behav Res Methods
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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14. Koya S, Li Y, McDaniel SA, LoBuglio AF, Krontiras H, Carpenter J, Nabell L, Bland K, Falkson C, Forero A: Safety and effectiveness of dose dense neoadjuvant chemotherapy in patients with stage II/III breast cancer. J Clin Oncol; 2009 May 20;27(15_suppl):e11566

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Safety and effectiveness of dose dense neoadjuvant chemotherapy in patients with stage II/III breast cancer.
  • : e11566 Background: NSABP B-18 randomized women with operable breast cancer to receive chemotherapy (AC) either pre- or postoperatively; in the study there was no significant difference in disease free survival (DFS) or overall survival (OS) among patients in either group.
  • Dose dense adjuvant chemotherapy (ATC) has shown a statistically significant improvement in DFS and OS.
  • Women with newly diagnosed breast cancer, T ≥ 3cm, any N, M0 were enrolled.
  • CONCLUSIONS: Our results show that dose dense neoadjuvant chemotherapy achieves a pCR (breast + node) in about 1/3 of patients (34%) with tolerable toxicity; although the number of patients is limited, our data suggest that triple negative breast cancer seems to be the most sensitive tumor to this regimen.

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  • (PMID = 27964074.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. Behlendorf T, Voigt W, Mueller T, Jordan K, Arnold D, Schmoll H: Activity of mTOR-Inhibitor Rad001 (everolimus) in differentiated and anaplastic thyroid cancer cell lines. J Clin Oncol; 2009 May 20;27(15_suppl):e14608

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Activity of mTOR-Inhibitor Rad001 (everolimus) in differentiated and anaplastic thyroid cancer cell lines.
  • : e14608 Background: Recent data suggest that aberrant activation of PIK3/AKT-pathway and mTOR are involved in the development of thyroid cancer, particularly of anaplastic (ATC) and follicular (FTC) subtype.
  • Therefore, mTOR could be a potential treatment target in thyroid cancer.
  • METHODS: To asses the potential role of mTOR as target for the treatment of thyroid cancer, two human ATC cell lines SW1736 and 8505C, the papillary thyroid cancer (PTC) cell line BCPAP and the FTC cell line FTC133 were exposed for 96h to increasing concentrations of the mTOR inhibitor RAD001 (Everolimus, kindly provided by Novartis, Switzerland).
  • CONCLUSION: RAD001 exerted interesting preclinical activity in two differentiated thyroid cancer cell lines.
  • Mainly additive drug interaction in thyroid cancer cell lines was observed for combinations with CDDP and DOX.
  • At least for differentiated thyroid cancer mTOR-inhibition appeared promising, further evaluation in thyroid cancer seems warranted.

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  • (PMID = 27964164.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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16. Haas V, Čelakovský P, Brtková J, Hornychová H: Unusual Manifestation of Anaplastic Thyroid Cancer. Acta Medica (Hradec Kralove); 2008;51(4):233-236

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Unusual Manifestation of Anaplastic Thyroid Cancer.
  • The diagnosis of anaplastic thyroid cancer was made after surgery and subsequent histological examination.
  • The histological examination of the lymph nodes identified metastasis of anaplastic thyroid cancer.
  • CONCLUSIONS: The differential diagnosis of diseases affecting deep neck structures can be very difficult.

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  • (PMID = 28113058.001).
  • [ISSN] 1211-4286
  • [Journal-full-title] Acta medica (Hradec Kralove)
  • [ISO-abbreviation] Acta Medica (Hradec Kralove)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Czech Republic
  • [Keywords] NOTNLM ; Anaplastic / Metastasis / Retropharyngeal abscess / Thyroid cancer
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17. Ha HT, Lee JS, Urba S, Koenig RJ, Sisson J, Giordano T, Worden FP: Phase II trial evaluating imatinib (I) in patients (pts) with anaplastic thyroid carcinoma (ATC). J Clin Oncol; 2009 May 20;27(15_suppl):6057

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Phase II trial evaluating imatinib (I) in patients (pts) with anaplastic thyroid carcinoma (ATC).
  • : 6057 Background: There is no standard treatment for ATC.
  • Affymetrix gene chip showed PDGFR overexpression in ATC.
  • In p53 mutated/deficient ATC cell lines, c-Abl is overexpressed, and selective inhibition of c-Abl resulted in cytostatic effect. (I) inhibits tyrosine kinase activity of Bcr-Abl and PDGF.
  • We hypothesize that ATC that overexpress PDGFR or Abl will respond to (I).
  • METHODS: Pts ≥ 18 years old with histologically confirmed ATC, overexpressing PDGFR or c-Abl by immunohistochemistry who had measurable disease were eligible.
  • Pts with complete response (CR)/partial responses (PR)/stable disease (SD) were treated until disease progression.
  • At baseline, 4/11 pts (36%) had locoregional disease, 5/11 pts (45%) had distant metastases, and 2/11 pts (18%) had both.
  • CONCLUSIONS: (I) appears to have activity in advanced ATC and is well tolerated.
  • Due to difficulty of accruing pts with a rare malignancy at a single institution, investigation of (I) in ATC may be warranted in a multi-institution setting.

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  • (PMID = 27961934.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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18. Nagaiah G, Fu P, Wasman JK, Cooney MM, Mooney C, Afshin D, Lavertu P, Bokar J, Savvides P, Remick SC, CTRU Research Nurses: Phase II trial of sorafenib (bay 43-9006) in patients with advanced anaplastic carcinoma of the thyroid (ATC). J Clin Oncol; 2009 May 20;27(15_suppl):6058

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Phase II trial of sorafenib (bay 43-9006) in patients with advanced anaplastic carcinoma of the thyroid (ATC).
  • We are conducting an open label, phase II study of sorafenib in patients with biopsy-proven ATC to evaluate if its objective response rate is >20% and to further characterize its safety profile.
  • METHODS: Patients with progressive ATC, after cytotoxic chemotherapy with or without radiation were given sorafenib, on a fixed dosing schedule of 400 mg PO bid on 28-day cycles.
  • Treatment was continued until disease progression, unacceptable toxicity or patient refusal.
  • Two of 15 evaluable patients (13%) have partial response (PR) and 4 patients (27%) have stable disease (SD).
  • One patient died on study with rapidly progressive disease.
  • CONCLUSIONS: Sorafenib demonstrates objective tumor response in the first 15 evaluable and pretreated patients with advanced ATC.

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  • (PMID = 27961935.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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19. Stimac D, Culig J, Vukusić I, Sostar Z, Tomić S, Bucalić M: Outpatient utilization patterns of the six main ATC drug groups in Republic of Croatia, city of Zagreb, and Croatia counties in 2004. Coll Antropol; 2009 Dec;33(4):1197-204

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Outpatient utilization patterns of the six main ATC drug groups in Republic of Croatia, city of Zagreb, and Croatia counties in 2004.
  • Zagreb Institute of Public Health in collaboration with the Croatian Drug Agency collected and analyzed data on outpatient utilization of the six main Anatomic-Therapeutic-Chemical (ATC) drug groups.

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  • (PMID = 20102069.001).
  • [ISSN] 0350-6134
  • [Journal-full-title] Collegium antropologicum
  • [ISO-abbreviation] Coll Antropol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study
  • [Publication-country] Croatia
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20. The selection and use of essential medicines. Report of the WHO expert committee, 2005 (including the 14th model list of essential medicines). World Health Organ Tech Rep Ser; 2006;(933):1-119, back cover

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Annexes to the main report include the revised version of the WHO Model List of Essential Medicines (the 14th) and a list of all items on the Model List sorted according to their 5-level Anatomical Therapeutic Chemical (ATC) classification codes.
  • [MeSH-major] Drugs, Essential / therapeutic use. Formularies as Topic. World Health Organization

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  • (PMID = 17566509.001).
  • [ISSN] 0512-3054
  • [Journal-full-title] World Health Organization technical report series
  • [ISO-abbreviation] World Health Organ Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Drugs, Essential
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21. Whitson E, Cordova ML, Demchak T, Stemmans CL, King KA: Certified athletic trainers' knowledge and perception of professional preparation involving eating disorders among athletes. J Allied Health; 2006;35(1):18-29
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Certified athletic trainers' knowledge and perception of professional preparation involving eating disorders among athletes.
  • The perceived adequacy of professional preparation about eating disorders and disordered eating has not been evaluated in certified athletic trainers (ATCs).
  • A 42-item Web-based survey was specifically created for this study and disseminated to certified 14,477 members of the National Athletic Trainers' Association (NATA), of whom 13.6% (n = 1,966) responded (mean age of respondents, 31.87 +/- 7.82 yrs).
  • Despite this finding, they also believe it is their responsibility to identify and deal with eating disordered athletes.

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  • (PMID = 16615293.001).
  • [ISSN] 0090-7421
  • [Journal-full-title] Journal of allied health
  • [ISO-abbreviation] J Allied Health
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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22. Milman G, Barnes AJ, Schwope DM, Schwilke EW, Darwin WD, Goodwin RS, Kelly DL, Gorelick DA, Huestis MA: Disposition of cannabinoids in oral fluid after controlled around-the-clock oral THC administration. Clin Chem; 2010 Aug;56(8):1261-9
Hazardous Substances Data Bank. delta 9-Tetrahydrocannabinol .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Disposition of cannabinoids in oral fluid after controlled around-the-clock oral THC administration.
  • METHODS: To characterize cannabinoid disposition in oral fluid, we administered around-the-clock oral Delta(9)-tetrahydrocannabinol (THC) (Marinol) doses to 10 participants with current daily cannabis use.
  • Samples were extracted with multiple elution solvents from a single SPE column and analyzed by 2-dimensional GC-MS with electron-impact ionization for THC, 11-hydroxy-THC (11-OH-THC), cannabidiol, and cannabinol and negative chemical ionization for 11-nor-9-carboxy-THC (THCCOOH).

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  • (PMID = 20530732.001).
  • [ISSN] 1530-8561
  • [Journal-full-title] Clinical chemistry
  • [ISO-abbreviation] Clin. Chem.
  • [Language] ENG
  • [Grant] United States / Intramural NIH HHS / / ZIA DA000412-13; United States / Intramural NIH HHS / / ZIA DA000413-13; United States / PHS HHS / / HHSN271200599091; United States / NIDA NIH HHS / DA / N01DA-5-9909
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 7J8897W37S / Dronabinol
  • [Other-IDs] NLM/ NIHMS317054; NLM/ PMC3171507
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23. Weidner TG, Henning JM: Importance and applicability of approved clinical instructor standards and criteria to certified athletic trainers in different clinical education settings. J Athl Train; 2005 Oct-Dec;40(4):326-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Importance and applicability of approved clinical instructor standards and criteria to certified athletic trainers in different clinical education settings.
  • CONTEXT: For optimal clinical education of athletic training students, Clinical Instructor Educators and program directors need to proactively select, train, and evaluate their Approved Clinical Instructors (ACIs).
  • OBJECTIVE: To assess the relative importance and applicability of ACI standards to certified athletic trainers employed in different athletic training clinical education settings.
  • CONCLUSIONS: The Weidner and Henning standards are considered to be important and applicable across a variety of athletic training clinical education settings.

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  • (PMID = 16404455.001).
  • [ISSN] 1062-6050
  • [Journal-full-title] Journal of athletic training
  • [ISO-abbreviation] J Athl Train
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1323295
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24. Brumels K, Beach A: Professional role complexity and job satisfaction of collegiate certified athletic trainers. J Athl Train; 2008 Jul-Aug;43(4):373-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Professional role complexity and job satisfaction of collegiate certified athletic trainers.
  • OBJECTIVE: To examine whether certified athletic trainers (ATs) employed at the collegiate level experienced professional role complexities, and if so, what effect those complexities had upon their job satisfaction and intent to leave a current position or the profession.

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  • (PMID = 18668170.001).
  • [ISSN] 1938-162X
  • [Journal-full-title] Journal of athletic training
  • [ISO-abbreviation] J Athl Train
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2474817
  • [Keywords] NOTNLM ; role ambiguity / role conflict / role overload
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25. Mazerolle SM, Scruggs IC, Casa DJ, Burton LJ, McDermott BP, Armstrong LE, Maresh CM: Current knowledge, attitudes, and practices of certified athletic trainers regarding recognition and treatment of exertional heat stroke. J Athl Train; 2010 Mar-Apr;45(2):170-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Current knowledge, attitudes, and practices of certified athletic trainers regarding recognition and treatment of exertional heat stroke.
  • CONTEXT: Previous research has indicated that despite awareness of the current literature on the recommended prevention and care of exertional heat stroke (EHS), certified athletic trainers (ATs) acknowledge failure to follow those recommendations.
  • RESULTS: Although most ATs (77.1%) have read the current National Athletic Trainers' Association position statement on heat illness, only 18.6% used rectal thermometers to assess core body temperature to recognize EHS, and 49.7% used cold-water immersion to treat EHS.
  • Athletic trainers perceived rectal thermometers as the most valid temperature assessment device when compared with other assessment devices (P <or= .05), but they used oral thermometers as the primary assessment tool (49.1%).
  • [MeSH-major] Health Knowledge, Attitudes, Practice. Heat Stroke / diagnosis. Heat Stroke / therapy. Physical Education and Training / manpower

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  • (PMID = 20210621.001).
  • [ISSN] 1938-162X
  • [Journal-full-title] Journal of athletic training
  • [ISO-abbreviation] J Athl Train
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2838469
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26. Aggarwal AN, Agarwal R, Gupta D: Automatic tube compensation as an adjunct for weaning in patients with severe neuroparalytic snake envenomation requiring mechanical ventilation: a pilot randomized study. Respir Care; 2009 Dec;54(12):1697-702

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Automatic tube compensation as an adjunct for weaning in patients with severe neuroparalytic snake envenomation requiring mechanical ventilation: a pilot randomized study.
  • OBJECTIVE: This study aimed to evaluate if the combination of pressure-support ventilation (PSV) and automatic tube compensation (ATC) is superior to PSV alone in weaning patients with severe neurotoxic snake envenoming receiving mechanical ventilation.
  • METHODS: Forty-one patients on volume controlled continuous mandatory ventilation were randomized to weaning with PSV alone (PSV group, 18 patients) or PSV plus ATC (ATC group, 23 patients).
  • The ATC group additionally, received inspiratory ATC at 100% through a ventilator-software-driven algorithm.
  • Median duration of weaning was significantly shorter in the ATC group than in the PSV group (8 h, 95% confidence interval 6.6-9.4 h vs 12 h, 95% confidence interval 9.9-14.1 h, P = .03 via log-rank test).
  • Median duration of mechanical ventilation and intensive-care-unit stay were similar between the PSV and the ATC groups (36.5 h, IQR 23.0-52.0 h vs 41.0 h, IQR 25.0-48.0 h, and 3.5 d, IQR 2-4 d vs 3 d, IQR 2-4 d, respectively).
  • Three patients in the PSV group and none in the ATC group developed pneumonia (P = .08).
  • CONCLUSION: The addition of ATC to a standard PSV-based weaning protocol significantly shortened time needed to wean patients with severe neurotoxic snake envenoming, without changing the duration of medical care, morbidity, or mortality.

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  • (PMID = 19961636.001).
  • [ISSN] 0020-1324
  • [Journal-full-title] Respiratory care
  • [ISO-abbreviation] Respir Care
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
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27. Cohen J, Shapiro M, Grozovski E, Fox B, Lev S, Singer P: Prediction of extubation outcome: a randomised, controlled trial with automatic tube compensation vs. pressure support ventilation. Crit Care; 2009;13(1):R21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prediction of extubation outcome: a randomised, controlled trial with automatic tube compensation vs. pressure support ventilation.
  • Some patients may not tolerate the trial because of the respiratory load imposed by the endotracheal tube, so varying levels of respiratory support are widely used during the trial.
  • Automatic tube compensation (ATC), specifically developed to overcome the imposed work of breathing because of artificial airways, appears ideally suited for the weaning process.
  • We further evaluated the use of ATC in this setting.
  • METHODS: In a prospective study, patients who had received mechanical ventilation for more than 24 hours and met defined criteria for a weaning trial, underwent a one-hour spontaneous breathing trial with either ATC (n = 87) or pressure support ventilation (PSV; n = 93).
  • In addition, we measured the frequency/tidal volume ratio (f/VT) both with (ATC-assisted) and without ATC (unassisted-f/VT) at the start of the breathing trial as a pretrial predictor of extubation outcome.
  • RESULTS: There were no significant differences in any of the baseline characteristics between the two groups apart from a significantly higher Acute Physiology and Chronic Health Evaluation (APACHE) II score in the ATC group (p = 0.009).
  • In the PSV group, 13 of 93 (14%) patients failed the breathing trial compared with only 6 of 87 (6%) in the ATC group; this observed 8% difference, however, did not reach statistical significance (p = 0.12).
  • The rate of reintubation was not different between the groups (total group = 17.3%; ATC = 18.4% vs. PSV = 12.9%, p = 0.43).
  • The percentage of patients who remained extubated for more than 48 hours was similar in both groups (ATC = 74.7% vs. PSV = 73.1%; p = 0.81).
  • This represented a positive predictive value for PSV of 0.85 and ATC of 0.80 (p = 0.87).
  • Finally, the ATC-assisted f/VT was found to have a significant contribution in predicting successful liberation and extubation compared with the non-significant contribution of the unassisted f/VT (unassisted f/VT, p = 0.19; ATC-assisted f/VT, p = 0.005).
  • CONCLUSIONS: This study confirms the usefulness of ATC during the weaning process, being at least as effective as PSV in predicting successful extubation outcome and significantly improving the predictive value of the f/VT.

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  • (PMID = 19236688.001).
  • [ISSN] 1466-609X
  • [Journal-full-title] Critical care (London, England)
  • [ISO-abbreviation] Crit Care
  • [Language] eng
  • [Databank-accession-numbers] ISRCTN/ ISRCTN16080446
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2688139
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28. Cohen JD, Shapiro M, Grozovski E, Lev S, Fisher H, Singer P: Extubation outcome following a spontaneous breathing trial with automatic tube compensation versus continuous positive airway pressure. Crit Care Med; 2006 Mar;34(3):682-6
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extubation outcome following a spontaneous breathing trial with automatic tube compensation versus continuous positive airway pressure.
  • OBJECTIVE: We hypothesized that the additional use of automatic tube compensation (ATC) during a spontaneous breathing trial with continuous positive airway pressure (CPAP), by minimizing respiratory work, would result in more patients undergoing successful extubation.
  • INTERVENTIONS: Patients were randomized to undergo a 1-hr spontaneous breathing trial with either ATC with CPAP (ATC group, n=51) or CPAP alone (CPAP group, n=48).
  • ATC was provided by commercially available mechanical ventilators.
  • There was a trend for more patients in the ATC group to tolerate the breathing trial and undergo extubation (96% vs. 85%; p=.08).
  • The rate of reintubation was 14% in the ATC group and 24% in the CPAP group (p=.28).
  • Significantly more patients in the ATC group thus met the criteria for successful extubation (82% vs. 65%; p=0.04).
  • CONCLUSION: This is the largest single-center study to date assessing the use of commercially available ATC and suggests that this might be a useful mode for performing a spontaneous breathing trial preceding extubation in a general intensive care population.

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  • [CommentIn] Crit Care Med. 2006 Nov;34(11):2867; author reply 2867 [17053584.001]
  • (PMID = 16505653.001).
  • [ISSN] 0090-3493
  • [Journal-full-title] Critical care medicine
  • [ISO-abbreviation] Crit. Care Med.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
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29. Ndong GP, Adam G, Mouala C, Faucherre V, Kouely PN, Sibeoni J, Courpotin C: [National coordination of the ambulatory treatment centers (ATC) in Gabon: a new process to conduct the scaling up of care for people living with HIV-AIDS]. Sante; 2008 Apr-Jun;18(2):97-102
MedlinePlus Health Information. consumer health - HIV/AIDS.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [National coordination of the ambulatory treatment centers (ATC) in Gabon: a new process to conduct the scaling up of care for people living with HIV-AIDS].
  • [Transliterated title] La coordination nationale des centres de traitement ambulatoire au Gabon : une expérience novatrice de décentralisation opérationnelle de la prise en charge du VIH-sida.
  • Starting from the experience conducted on three ambulatory treatment centers (ATC) [Libreville, Franceville, Port-Gentil] in collaboration with the French Red Cross, Gabonese authorities decided the scaling up of HIV patients' care to seven new ATC at a national level.
  • Technical and medical supervision of the ten ATC were attributed to the French Red Cross by Gabonese authorities with the financial support of the French Agency for Development.
  • The ten ATC, founded by the ministry of public health, were then organized within a network under the responsibility of a national coordination.
  • This structure created in September 2007 represents the main organism to conduct, evaluate and follow-up activities and functioning of the ten ATC.
  • In June 2007, 5 ATC were in function taking care of 7,062 PLWA.
  • In November 2008, 9 ATC were in function taking care of 8,174 PLWA.
  • [MeSH-minor] Anti-Retroviral Agents / therapeutic use. France. Gabon. Humans. Quality of Life

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  • Genetic Alliance. consumer health - HIV.
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  • (PMID = 19188133.001).
  • [ISSN] 1157-5999
  • [Journal-full-title] Santé (Montrouge, France)
  • [ISO-abbreviation] Sante
  • [Language] fre
  • [Publication-type] Comparative Study; English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Anti-Retroviral Agents
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30. Takarabe M, Shigemizu D, Kotera M, Goto S, Kanehisa M: Characterization and classification of adverse drug interactions. Genome Inform; 2010 Jan;22:167-75
MedlinePlus Health Information. consumer health - Medicines.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Characterization and classification of adverse drug interactions.
  • In this study, we further analyzed the obtained drug interaction network by merging drugs into drug categories based on the Anatomical Therapeutic Chemical (ATC) classification.
  • [MeSH-major] Drug Interactions. Drug-Related Side Effects and Adverse Reactions / epidemiology. Pharmaceutical Preparations / classification

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  • (PMID = 20238427.001).
  • [ISSN] 0919-9454
  • [Journal-full-title] Genome informatics. International Conference on Genome Informatics
  • [ISO-abbreviation] Genome Inform
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Pharmaceutical Preparations
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31. WHO Expert Committee: The selection and use of essential medicines. World Health Organ Tech Rep Ser; 2007;(946):1-162, back cover

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Annexes to the main report include the revised version of the WHO Model List of Essential Medicines (the 15th) and a list of all items on the Model List sorted according to their 5-level Anatomical Therapeutic Chemical (ATC) classification codes.

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  • (PMID = 18309920.001).
  • [ISSN] 0512-3054
  • [Journal-full-title] World Health Organization technical report series
  • [ISO-abbreviation] World Health Organ Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Drugs, Essential
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32. Marra J, Covassin T, Shingles RR, Canady RB, Mackowiak T: Assessment of certified athletic trainers' levels of cultural competence in the delivery of health care. J Athl Train; 2010 Jul-Aug;45(4):380-5
MedlinePlus Health Information. consumer health - Sports Fitness.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Assessment of certified athletic trainers' levels of cultural competence in the delivery of health care.
  • CONTEXT: The concept of culture and its relationship to athletic training beliefs and practices is virtually unexplored.
  • OBJECTIVE: To assess the cultural competence levels of certified athletic trainers (ATs) in their delivery of health care services and to examine the relationship between cultural competence and sex, race/ethnicity, years of athletic training experience, and National Athletic Trainers' Association (NATA) district.
  • SETTING: Certified member database of the NATA.
  • Educators and employers can use these results to help develop diversity training education for ATs and athletic training students.

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  • [Cites] J Transcult Nurs. 2002 Jul;13(3):181-4; discussion 200-1 [12113146.001]
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  • (PMID = 20617913.001).
  • [ISSN] 1938-162X
  • [Journal-full-title] Journal of athletic training
  • [ISO-abbreviation] J Athl Train
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2902032
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33. Sakji S, Letord C, Dahamna B, Kergourlay I, Pereira S, Joubert M, Darmoni S: Automatic indexing in a drug information portal. Stud Health Technol Inform; 2009;148:112-22
MedlinePlus Health Information. consumer health - Medicines.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Automatic indexing in a drug information portal.
  • OBJECTIVE: The objective of this work is to create a bilingual (French/English) Drug Information Portal (DIP), in a multi-terminological context and to emphasize its exploitation by an ATC automatic indexing allowing having more pertinent information about substances, organs or systems on which drugs act and their therapeutic and chemical characteristics.
  • DIP has created specific functionalities and uses specific drugs terminologies such as the ATC classification which used to automatic index the DIP resources.
  • The ATC automatic indexing provided relevant results in 76% of cases.

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  • (PMID = 19745241.001).
  • [ISSN] 0926-9630
  • [Journal-full-title] Studies in health technology and informatics
  • [ISO-abbreviation] Stud Health Technol Inform
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Pharmaceutical Preparations
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34. WHO Expert Committee: The selection and use of essential medicines. World Health Organ Tech Rep Ser; 2008;(950):backcover, vii-174

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Appendices to the main report include the first WHO Model List of Essential Medicines for Children, a list of all the items it contains sorted according to their 5-level Anatomical Therapeutic Chemical (ATC) classification codes and a summary of medicines to be reviewed before the next meeting of the Subcommittee.
  • [MeSH-major] Drugs, Essential / therapeutic use. World Health Organization

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  • (PMID = 18754303.001).
  • [ISSN] 0512-3054
  • [Journal-full-title] World Health Organization technical report series
  • [ISO-abbreviation] World Health Organ Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article; Technical Report
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Drugs, Essential
  • [Investigator] Al-Fannah JM; Coelho H; Cranswick N; Gilani AU; Gray A; Gupta U; Helali A; Hoppu K; Irs A; Kazembe P; Mehta D; Reidenberg M; Suryawati S; Walters S; Pedersen HB; Chongtrakul P; Zhiping L; Nakamura H; Robertson J; Hill S; Hogerzeil H; Ondari C; Zisovska E; Davies EH; Kearns G; Mattison D; Terlouw D
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35. WHO Expert Committee: The selection and use of essential medicines. World Health Organ Tech Rep Ser; 2009;(958):1-242, back cover

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In addition there is a list of all the items on the Model List sorted according to their Anatomical Therapeutic Chemical (ATC) classification codes.

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  • (PMID = 20560299.001).
  • [ISSN] 0512-3054
  • [Journal-full-title] World Health Organization technical report series
  • [ISO-abbreviation] World Health Organ Tech Rep Ser
  • [Language] eng
  • [Publication-type] Consensus Development Conference; Journal Article; Technical Report
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Dosage Forms; 0 / Drugs, Essential
  • [Number-of-references] 184
  • [Investigator] Al-Fannah JM; Bero LA; Cheraghali AM; Cranswick N; Dodoo AN; Fernandopulle R; Gray A; Henkens M; Hoppu K; Kearns GL; Delgado EJ; Reidenberg MM; Wannmacher L; Zaidi A; Batmanabane G; Hua DY; How CH; Zisovska E; Kozarewicz P; Pedersen HB; Wolman Y; Fauveau V; Doedens W; Hogerzeil HV; Ondari C; Hill S; Ridge A; Akmal R
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36. Yard EE, Collins CL, Comstock RD: A comparison of high school sports injury surveillance data reporting by certified athletic trainers and coaches. J Athl Train; 2009 Nov-Dec;44(6):645-52
MedlinePlus Health Information. consumer health - Sports Injuries.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A comparison of high school sports injury surveillance data reporting by certified athletic trainers and coaches.
  • OBJECTIVE: To examine the feasibility of relying on high school coaches as data reporters in a national, Internet-based sports injury surveillance study, using the same methods that have already proven successful in the National High School Sports-Related Injury Surveillance Study, which calls on certified athletic trainers (ATs) as reporters.
  • SETTING: Eighteen United States high schools PARTICIPANTS: Athletic trainers and varsity coaches for football, boys' and girls' soccer, and boys' and girls' basketball.
  • The reports submitted by ATs and coaches for the same injury had low agreement for diagnosis and time loss, with only 63.2% and 55.3% of pairs, respectively, providing the same response.
  • [MeSH-major] Athletic Injuries / epidemiology. Schools / statistics & numerical data. Sports Medicine / statistics & numerical data

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  • (PMID = 19911092.001).
  • [ISSN] 1938-162X
  • [Journal-full-title] Journal of athletic training
  • [ISO-abbreviation] J Athl Train
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2775367
  • [Keywords] NOTNLM ; injury epidemiology / methodologies
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37. Rodrigues RF, Roque L, Krug T, Leite V: Poorly differentiated and anaplastic thyroid carcinomas: chromosomal and oligo-array profile of five new cell lines. Br J Cancer; 2007 Apr 23;96(8):1237-45
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Poorly differentiated and anaplastic thyroid carcinomas: chromosomal and oligo-array profile of five new cell lines.
  • Information on gene alterations associated to poorly differentiated (PDTC) and anaplastic thyroid carcinomas (ATC) is scarce.
  • Using human cancer cell lines as a tool for gene discovery, we performed a cytogenetic and oligo-array analysis in five new cell lines derived from two PDTC and three ATC.
  • In ATC, downregulation of a specific group of oncosuppressor genes was also observed.
  • Our ATC cell lines presented chromosomal markers of gene amplification, and we were able to identify for the first time the nature of the involved amplicon target genes.
  • TaqMan experiments performed for five amplicon target genes and for two genes, which allowed a clear distinction between ATC and PDTC: CDH13 and PLAU corroborated array results, not only in the cell lines, but also in an additional set of primary 14 PDTC and three ATC.
  • We suggest that our findings may represent new tools for the development of more effective therapies to the hitherto untreatable ATC.
  • [MeSH-major] Chromosome Aberrations. Gene Expression Profiling. Thyroid Neoplasms / genetics


38. Goodman A, Mensch JM, Jay M, French KE, Mitchell MF, Fritz SL: Retention and attrition factors for female certified athletic trainers in the National Collegiate Athletic Association Division I Football Bowl Subdivision setting. J Athl Train; 2010 May-Jun;45(3):287-98
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Retention and attrition factors for female certified athletic trainers in the National Collegiate Athletic Association Division I Football Bowl Subdivision setting.
  • However, little is known about the retention and attrition of female certified athletic trainers (ATs) in certain settings.
  • OBJECTIVE: To gain insight and understanding into the factors and circumstances affecting female ATs' decisions to persist in or leave the National Collegiate Athletic Association Division I Football Bowl Subdivision (NCAA D-I FBS) setting.
  • [MeSH-major] Athletic Injuries. Burnout, Professional. Football / injuries. Personnel Turnover / statistics & numerical data. Sports Medicine / manpower

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  • MedlinePlus Health Information. consumer health - Sports Injuries.
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  • (PMID = 20446843.001).
  • [ISSN] 1938-162X
  • [Journal-full-title] Journal of athletic training
  • [ISO-abbreviation] J Athl Train
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2865968
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39. Cariou JL: [Composite tissues allotransplantation (CTA). Conclusions]. Ann Chir Plast Esthet; 2007 Oct;52(5):551-3
MedlinePlus Health Information. consumer health - Plastic and Cosmetic Surgery.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Allotransplantation de tissus composites (ATC). Conclusions.

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  • (PMID = 17766025.001).
  • [ISSN] 0294-1260
  • [Journal-full-title] Annales de chirurgie plastique et esthétique
  • [ISO-abbreviation] Ann Chir Plast Esthet
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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40. Mazerolle SM, Bruening JE, Casa DJ: Work-family conflict, part I: Antecedents of work-family conflict in national collegiate athletic association division I-A certified athletic trainers. J Athl Train; 2008 Sep-Oct;43(5):505-12
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Work-family conflict, part I: Antecedents of work-family conflict in national collegiate athletic association division I-A certified athletic trainers.
  • To date, few authors have examined work-family conflict within the athletic training profession.
  • OBJECTIVE: To investigate the occurrence of WFC in certified athletic trainers (ATs) and to identify roots and factors leading to quality-of-life issues for ATs working in the National Collegiate Athletic Association Division I-A setting.

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  • (PMID = 18833313.001).
  • [ISSN] 1938-162X
  • [Journal-full-title] Journal of athletic training
  • [ISO-abbreviation] J Athl Train
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2547870
  • [Keywords] NOTNLM ; job responsibilities / quality of life / work load
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41. Pitney WA: Organizational influences and quality-of-life issues during the professional socialization of certified athletic trainers working in the National Collegiate Athletic Association Division I setting. J Athl Train; 2006 Apr-Jun;41(2):189-95
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Organizational influences and quality-of-life issues during the professional socialization of certified athletic trainers working in the National Collegiate Athletic Association Division I setting.
  • Little is known about the organizational socialization of certified athletic trainers (ATs) in the collegiate context.
  • OBJECTIVE: To discuss the organizational influences and quality-of-life issues as each relates to the professional socialization of ATs working in the National Collegiate Athletic Association Division I setting.
  • SETTING: Participants associated with Division I athletic programs from 4 National Athletic Trainers' Association districts volunteered for the study.
  • PARTICIPANTS: A total of 11 men and 5 women participated in the study, consisting of 14 ATs and 2 athletic directors.
  • The data indicate that the participants in this study were heavily influenced by the bureaucratic tendencies of the Division I athletic organizations in which they worked.

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  • (PMID = 16791305.001).
  • [ISSN] 1062-6050
  • [Journal-full-title] Journal of athletic training
  • [ISO-abbreviation] J Athl Train
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1472645
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42. Karabay O, Hosoglu S: Increased antimicrobial consumption following reimbursement reform in Turkey. J Antimicrob Chemother; 2008 May;61(5):1169-71
MedlinePlus Health Information. consumer health - Antibiotics.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The anatomical therapeutic chemical (ATC) classification and the defined daily dose (DDD) methodology were used to calculate antibiotic consumption.
  • [MeSH-major] Anti-Bacterial Agents / therapeutic use. Drug Utilization / trends. Reimbursement Mechanisms / standards

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  • (PMID = 18272511.001).
  • [ISSN] 1460-2091
  • [Journal-full-title] The Journal of antimicrobial chemotherapy
  • [ISO-abbreviation] J. Antimicrob. Chemother.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents
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43. Abu-Khalaf MM, Windsor S, Ebisu K, Salikooti S, Ananthanarayanan G, Chung GG, DiGiovanna MP, Haffty BG, Abrams M, Farber LR, Hsu AD, Reiss M, Zelterman D, Burtness BA: Five-year update of an expanded phase II study of dose-dense and -intense doxorubicin, paclitaxel and cyclophosphamide (ATC) in high-risk breast cancer. Oncology; 2005;69(5):372-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Five-year update of an expanded phase II study of dose-dense and -intense doxorubicin, paclitaxel and cyclophosphamide (ATC) in high-risk breast cancer.
  • OBJECTIVES: This study evaluated the safety and efficacy of dose-dense and -intense sequential doxorubicin (A), paclitaxel (T) and cyclophosphamide (C) as adjuvant therapy for breast cancer (BC) with >or=4 ipsilateral axillary lymph nodes.
  • METHODS: Patients were recruited after BC surgery if >or=4 axillary nodes were involved by metastatic cancer.
  • Sixty-nine (81%) patients are alive, and 59 (69%) patients are alive and free of distant disease at a median follow-up of 5 years.
  • CONCLUSIONS: ATC is a feasible regimen for adjuvant therapy of high-risk BC, with a relatively low rate of relapse at the 5-year follow up.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Breast Neoplasms / drug therapy. Cyclophosphamide / administration & dosage. Doxorubicin / administration & dosage. Paclitaxel / administration & dosage
  • [MeSH-minor] Adult. Aged. Disease-Free Survival. Dose-Response Relationship, Drug. Female. Follow-Up Studies. Humans. Lymphatic Metastasis. Middle Aged. Neoplasm Metastasis. Time Factors

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  • (PMID = 16319508.001).
  • [ISSN] 0030-2414
  • [Journal-full-title] Oncology
  • [ISO-abbreviation] Oncology
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30CA16359
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; P88XT4IS4D / Paclitaxel
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44. Goede A, Dunkel M, Mester N, Frommel C, Preissner R: SuperDrug: a conformational drug database. Bioinformatics; 2005 May 1;21(9):1751-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Furthermore, for selection purposes or for correlation of structural similarity with medical application, the assignment of the Anatomical Therapeutic Chemical (ATC) classification codes to each structure according to the WHO-scheme would be desirable.
  • Here we present a web-query system enabling searches for drug name, synonyms, trade name, trivial name, formula, CAS-number, ATC-code etc.
  • 2D-similarity screening (Tanimoto coefficients) and an automatic 3D-superposition procedure based on conformational representation are implemented.
  • AVAILABILITY: For academic use the system is accessible at http://bioinf.charite.de/superdrug.
  • The retrieval system requires the free browser-plugin 'chime' from MDL for visualization.

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  • (PMID = 15691861.001).
  • [ISSN] 1367-4803
  • [Journal-full-title] Bioinformatics (Oxford, England)
  • [ISO-abbreviation] Bioinformatics
  • [Language] eng
  • [Publication-type] Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Pharmaceutical Preparations
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45. Borg MA, Zarb P, Ferech M, Goossens H, ARMed Project Group: Antibiotic consumption in southern and eastern Mediterranean hospitals: results from the ARMed project. J Antimicrob Chemother; 2008 Oct;62(4):830-6
MedlinePlus Health Information. consumer health - Antibiotics.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The surveillance focused primarily on systemic antibiotics used in hospital care, aggregated at the level of the active substance, in accordance with the Anatomic Therapeutic Chemical (ATC) classification.
  • [MeSH-major] Anti-Bacterial Agents / therapeutic use. Drug Utilization / statistics & numerical data

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  • (PMID = 18593724.001).
  • [ISSN] 1460-2091
  • [Journal-full-title] The Journal of antimicrobial chemotherapy
  • [ISO-abbreviation] J. Antimicrob. Chemother.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents
  • [Investigator] Gür D; Ben Redjeb S; Rasslan O; Elnassar Z; Bagatzouni DP; Daoud Z
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46. Wawruch M, Bozekova L, Tisonova J, Raganova A, Lassanova M, Hudec R, Vojtko R, Gazova A, Kriska M: The Slovak Drug Information (Druginfo) Centre during the period 1997-2004. Bratisl Lek Listy; 2005;106(3):133-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • According to the ATC classification the questions were most often related to antiinfective drugs, cardiovascular drugs and psychiatric drugs.

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  • (PMID = 16026149.001).
  • [ISSN] 0006-9248
  • [Journal-full-title] Bratislavské lekárske listy
  • [ISO-abbreviation] Bratisl Lek Listy
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Slovakia
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47. Tlustá E, Ulmanová D, Vitásek Z, Vlcek J: [Consumption of old and new antiepileptic drugs in the Czech Republic in 1999-2004]. Ceska Slov Farm; 2007 Jan;56(1):37-41

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The AEDs utilization was assessed according to ATC/DDD methodology on the fourth and fifth level of the ATC classification and expressed as the number of defined daily doses per 1000 insured per day (DDD/TID).
  • [MeSH-major] Anticonvulsants / therapeutic use

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  • (PMID = 17432281.001).
  • [ISSN] 1210-7816
  • [Journal-full-title] Ceská a Slovenská farmacie : casopis Ceské farmaceutické spolecnosti a Slovenské farmaceutické spolecnosti
  • [ISO-abbreviation] Ceska Slov Farm
  • [Language] cze
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Czech Republic
  • [Chemical-registry-number] 0 / Anticonvulsants
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48. Gurulingappa H, Kolárik C, Hofmann-Apitius M, Fluck J: Concept-based semi-automatic classification of drugs. J Chem Inf Model; 2009 Aug;49(8):1986-92
MedlinePlus Health Information. consumer health - Medicines.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Concept-based semi-automatic classification of drugs.
  • The anatomical therapeutic chemical (ATC) classification system maintained by the World Health Organization provides a global standard for the classification of medical substances and serves as a source for drug repurposing research.
  • Therefore, an IE-based framework is employed to extract terms from free text that express drug's chemical, pharmacological, therapeutic, and systemic effects.
  • The extracted terms are used as features within a ML framework to predict putative ATC class labels for unclassified drugs.
  • The system was tested on a portion of ATC containing drugs with an indication on the cardiovascular system.
  • The presented concept-based classification system outperformed state-of-the-art classification methods based on chemical structure properties.
  • [MeSH-major] Artificial Intelligence. Pharmaceutical Preparations / classification

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  • (PMID = 19663460.001).
  • [ISSN] 1549-9596
  • [Journal-full-title] Journal of chemical information and modeling
  • [ISO-abbreviation] J Chem Inf Model
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Pharmaceutical Preparations
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49. Mazerolle SM, Bruening JE, Casa DJ, Burton LJ: Work-family conflict, part II: Job and life satisfaction in national collegiate athletic association division I-A certified athletic trainers. J Athl Train; 2008 Sep-Oct;43(5):513-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Work-family conflict, part II: Job and life satisfaction in national collegiate athletic association division I-A certified athletic trainers.
  • However, WFC and its consequences have not yet been fully investigated among certified athletic trainers.
  • OBJECTIVE: To investigate the relationship between WFC and various outcome variables among certified athletic trainers working in National Collegiate Athletic Association Division I-A settings.
  • PATIENTS OR OTHER PARTICIPANTS: A total of 587 athletic trainers (324 men, 263 women) responded to the questionnaire, and 12 (6 men, 6 women) participated in the qualitative portion of the mixed-methods study.

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  • (PMID = 18833314.001).
  • [ISSN] 1938-162X
  • [Journal-full-title] Journal of athletic training
  • [ISO-abbreviation] J Athl Train
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2547871
  • [Keywords] NOTNLM ; attrition / burnout
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50. Smidt D, Torpet LA, Nauntofte B, Heegaard KM, Pedersen AM: Associations between labial and whole salivary flow rates, systemic diseases and medications in a sample of older people. Community Dent Oral Epidemiol; 2010 Oct;38(5):422-35

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Systemic diseases, medications (coded according to the Anatomical Therapeutic Chemical (ATC) Classification System), tobacco and alcohol consumption were registered.
  • New insights into medications and their association with salivary gland function were achieved using the ATC classification system.
  • [MeSH-minor] Age Factors. Aged. Aged, 80 and over. Chi-Square Distribution. Cross-Sectional Studies. Disease. Drug-Related Side Effects and Adverse Reactions. Female. Humans. Linear Models. Lip / physiology. Male. Mastication / physiology. Salivary Glands / drug effects. Salivary Glands / physiology. Sex Factors

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  • [Copyright] © 2010 John Wiley & Sons A/S.
  • (PMID = 20545715.001).
  • [ISSN] 1600-0528
  • [Journal-full-title] Community dentistry and oral epidemiology
  • [ISO-abbreviation] Community Dent Oral Epidemiol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
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51. Al-Bakri AG, Bustanji Y, Yousef AM: Community consumption of antibacterial drugs within the Jordanian population: sources, patterns and appropriateness. Int J Antimicrob Agents; 2005 Nov;26(5):389-95
MedlinePlus Health Information. consumer health - Antibiotics.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Dispensed antibacterial drugs belonged to eight different main classes of systemically used antibacterial drugs in accordance with the Anatomical Therapeutic Chemical (ATC) classification system.
  • [MeSH-major] Anti-Bacterial Agents / therapeutic use

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  • (PMID = 16221541.001).
  • [ISSN] 0924-8579
  • [Journal-full-title] International journal of antimicrobial agents
  • [ISO-abbreviation] Int. J. Antimicrob. Agents
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Nonprescription Drugs
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52. Sorrentino R, Libertini S, Pallante PL, Troncone G, Palombini L, Bavetsias V, Spalletti-Cernia D, Laccetti P, Linardopoulos S, Chieffi P, Fusco A, Portella G: Aurora B overexpression associates with the thyroid carcinoma undifferentiated phenotype and is required for thyroid carcinoma cell proliferation. J Clin Endocrinol Metab; 2005 Feb;90(2):928-35
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Aurora B overexpression associates with the thyroid carcinoma undifferentiated phenotype and is required for thyroid carcinoma cell proliferation.
  • Loss of mitotic regulation is believed to induce aneuploidy in cancer cells and act as a driving force during the malignant progression.
  • We analyzed Aurora B expression in human thyroid carcinomas.
  • Immunohistochemical analysis of archive samples showed a high expression of Aurora B in anaplastic thyroid carcinomas; conversely, Aurora B expression was not detectable in normal thyroid tissue.
  • Real-time PCR analysis confirmed a strong expression of Aurora B in anaplastic thyroid carcinomas.
  • The block of Aurora B expression induced by RNA interference or by using an inhibitor of Aurora kinase activity significantly reduced the growth of thyroid anaplastic carcinoma cells.
  • [MeSH-major] Protein-Serine-Threonine Kinases / genetics. Thyroid Neoplasms / genetics
  • [MeSH-minor] Animals. Aurora Kinase B. Aurora Kinases. Base Sequence. Carcinoma / enzymology. Carcinoma / genetics. Carcinoma / pathology. Cell Division. Cell Line, Tumor. DNA Primers. Gene Expression Regulation, Enzymologic. Gene Expression Regulation, Neoplastic. Humans. Mice. Mice, Nude. Phenotype. Reverse Transcriptase Polymerase Chain Reaction. Transplantation, Heterologous

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  • (PMID = 15562011.001).
  • [ISSN] 0021-972X
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA Primers; EC 2.7.11.1 / AURKB protein, human; EC 2.7.11.1 / Aurkb protein, mouse; EC 2.7.11.1 / Aurora Kinase B; EC 2.7.11.1 / Aurora Kinases; EC 2.7.11.1 / Protein-Serine-Threonine Kinases
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53. Besic N, Hocevar M, Zgajnar J, Pogacnik A, Grazio-Frkovic S, Auersperg M: Prognostic factors in anaplastic carcinoma of the thyroid-a multivariate survival analysis of 188 patients. Langenbecks Arch Surg; 2005 Jun;390(3):203-8
MedlinePlus Health Information. consumer health - Thyroid Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prognostic factors in anaplastic carcinoma of the thyroid-a multivariate survival analysis of 188 patients.
  • BACKGROUND: Multivariate studies concerning the prognosis of patients with anaplastic carcinoma of the thyroid gland are scarce.
  • The aim of our study was to determine the prognostic factors associated with survival of patients with anaplastic carcinoma in Slovenia, an iodine-deficient region.
  • METHODS: This retrospective study was carried out on a group of 188 patients (130 female, 58 male; median age 68 years) with anaplastic carcinoma of the thyroid who had been treated at a tertiary care centre from 1972 to 2003.
  • For each patient, data on gender, age, disease history, extent of disease, morphological characteristics, mode of therapy, and survival were collected.
  • CONCLUSION: Patients younger than 71 years, with a good performance status and slowly growing tumours confined to the thyroid, and without distant metastases, had the best prognosis.
  • [MeSH-major] Carcinoma / mortality. Carcinoma / therapy. Thyroid Neoplasms / mortality. Thyroid Neoplasms / therapy

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  • (PMID = 15599758.001).
  • [ISSN] 1435-2443
  • [Journal-full-title] Langenbeck's archives of surgery
  • [ISO-abbreviation] Langenbecks Arch Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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54. Blix HS, Hartug S: Hospital usage of antibacterial agents in relation to size and type of hospital and geographical situation. Pharmacoepidemiol Drug Saf; 2005 Sep;14(9):647-9
MedlinePlus Health Information. consumer health - Health Facilities.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Drugs were classified according to the ATC classification and the ATC/DDD index 2001 and standardised bed-days were used.
  • However, therapeutic choice of antibacterial agents differs and seems to be influenced by hospital size and hospital type.

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  • [Copyright] (c) 2005 John Wiley & Sons, Ltd.
  • (PMID = 15700320.001).
  • [ISSN] 1053-8569
  • [Journal-full-title] Pharmacoepidemiology and drug safety
  • [ISO-abbreviation] Pharmacoepidemiol Drug Saf
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents
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55. Wirtz VJ, Dreser A, Gonzales R: Trends in antibiotic utilization in eight Latin American countries, 1997-2007. Rev Panam Salud Publica; 2010 Mar;27(3):219-25
MedlinePlus Health Information. consumer health - Antibiotics.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To describe the trends in antibiotic utilization in eight Latin American countries between 1997-2007 METHODS: We analyzed retail sales data of oral and injectable antibiotics (World Health Organization (WHO) Anatomic Therapeutic Chemical (ATC) code J01) between 1997 and 2007 for Argentina, Brazil, Chile, Colombia, Mexico, Peru, Uruguay, and Venezuela.
  • The kilogram sales of each antibiotic were converted into defined daily dose per 1 000 inhabitants per day (DID) according to the WHO ATC classification system.
  • [MeSH-major] Anti-Bacterial Agents / therapeutic use

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  • (PMID = 20414511.001).
  • [ISSN] 1680-5348
  • [Journal-full-title] Revista panamericana de salud pública = Pan American journal of public health
  • [ISO-abbreviation] Rev. Panam. Salud Publica
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents
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56. Uchida N, Chong MY, Tan CH, Nagai H, Tanaka M, Lee MS, Fujii S, Yang SY, Si T, Sim K, Wei H, Ling HY, Nishimura R, Kawaguchi Y, Edwards G, Sartorius N, Shinfuku N: International study on antidepressant prescription pattern at 20 teaching hospitals and major psychiatric institutions in East Asia: Analysis of 1898 cases from China, Japan, Korea, Singapore and Taiwan. Psychiatry Clin Neurosci; 2007 Oct;61(5):522-8
MedlinePlus Health Information. consumer health - Antidepressants.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Out of 56 antidepressants listed in the Anatomical Therapeutic Chemical Classification (ATC) index by the World Health Organization (WHO) Collaborating Center for Drug Statistics Methodology (Oslo), only 26 antidepressants were prescribed in participating countries in East Asia.
  • [MeSH-major] Antidepressive Agents / therapeutic use. Cross-Cultural Comparison. Depressive Disorder / drug therapy. Drug Prescriptions / statistics & numerical data. Hospitals, Psychiatric / statistics & numerical data. Hospitals, Teaching / statistics & numerical data
  • [MeSH-minor] Adult. Antidepressive Agents, Second-Generation / therapeutic use. China. Cross-Sectional Studies. Drug Utilization / statistics & numerical data. Female. Humans. Japan. Korea. Male. Middle Aged. Serotonin Uptake Inhibitors / therapeutic use. Singapore. Taiwan. World Health Organization

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  • (PMID = 17875031.001).
  • [ISSN] 1323-1316
  • [Journal-full-title] Psychiatry and clinical neurosciences
  • [ISO-abbreviation] Psychiatry Clin. Neurosci.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antidepressive Agents; 0 / Antidepressive Agents, Second-Generation; 0 / Serotonin Uptake Inhibitors
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57. Deters M, Prasa D, Hentschel H, Schaper A: Iatrogenic intravenous medication errors reported to the GIZ-Nord Poisons Center Göttingen. Eur J Intern Med; 2009 Nov;20(7):728-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The drug classes (ATC classification) involved most frequently were antipsychotics (7.9%) and antithrombotic agents (6.0%).
  • [MeSH-major] Iatrogenic Disease / epidemiology. Medication Errors / statistics & numerical data. Poison Control Centers / statistics & numerical data

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  • (PMID = 19818296.001).
  • [ISSN] 1879-0828
  • [Journal-full-title] European journal of internal medicine
  • [ISO-abbreviation] Eur. J. Intern. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antipsychotic Agents; 0 / Bronchodilator Agents; C137DTR5RG / Theophylline
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58. Turkdogan FI, Yetilmezsoy K: Appraisal of potential environmental risks associated with human antibiotic consumption in Turkey. J Hazard Mater; 2009 Jul 15;166(1):297-308
MedlinePlus Health Information. consumer health - Antibiotics.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Antibiotics were defined for systemic use or group J01 of the WHO Anatomical Therapeutic Chemical (ATC) classification system.
  • Total emissions and prescriptions for each ATC group were classified separately into 17 different J01 categories and three forms of medication (capsule/tablets, injectables and suspensions).
  • [MeSH-major] Anti-Bacterial Agents / analysis. Water Pollutants, Chemical / analysis

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  • (PMID = 19100684.001).
  • [ISSN] 1873-3336
  • [Journal-full-title] Journal of hazardous materials
  • [ISO-abbreviation] J. Hazard. Mater.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Dosage Forms; 0 / Water Pollutants, Chemical
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59. Sakji S, Letord C, Pereira S, Dahamna B, Joubert M, Darmoni J: Drug information portal in Europe: information retrieval with multiple health terminologies. Stud Health Technol Inform; 2009;150:497-501
MedlinePlus Health Information. consumer health - Medicines.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • DIP has created specific functionalities related to drug and used specific drugs terminologies and classifications: the ATC classification, the CAS numbers, the French codes CIS, and CIP, as well as trade names and the International Nonproprietary Names of the drugs.

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  • (PMID = 19745361.001).
  • [ISSN] 0926-9630
  • [Journal-full-title] Studies in health technology and informatics
  • [ISO-abbreviation] Stud Health Technol Inform
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Pharmaceutical Preparations
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60. Jakimavicius M, Sveikata A, Vainauskas P, Jankūnas R, Mikucionyte L, Sapoliene A, Smigelskas K: Analysis of antidepressant prescribing tendencies in Lithuania in 2003-2004. Medicina (Kaunas); 2007;43(5):412-8
MedlinePlus Health Information. consumer health - Depression.

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  • Antidepressants were classified into three groups according to Anatomic Therapeutic Chemical (ATC) Classification specifying the defined daily doses.
  • Additional studies should be carried out in order to assess drug-prescribing patterns in accordance with the guidelines of depression treatment in Lithuania considering diagnosis, dosage, and duration of treatment.
  • [MeSH-major] Antidepressive Agents / therapeutic use. Depression / drug therapy. Drug Prescriptions / statistics & numerical data
  • [MeSH-minor] Adult. Age Factors. Aged. Antidepressive Agents, Second-Generation / administration & dosage. Antidepressive Agents, Second-Generation / economics. Antidepressive Agents, Second-Generation / therapeutic use. Antidepressive Agents, Tricyclic / administration & dosage. Antidepressive Agents, Tricyclic / economics. Antidepressive Agents, Tricyclic / therapeutic use. Female. Humans. Insurance, Health, Reimbursement. Lithuania. Male. Middle Aged. Serotonin Uptake Inhibitors / administration & dosage. Serotonin Uptake Inhibitors / economics. Serotonin Uptake Inhibitors / therapeutic use. Time Factors

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  • (PMID = 17563418.001).
  • [ISSN] 1648-9144
  • [Journal-full-title] Medicina (Kaunas, Lithuania)
  • [ISO-abbreviation] Medicina (Kaunas)
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] Lithuania
  • [Chemical-registry-number] 0 / Antidepressive Agents; 0 / Antidepressive Agents, Second-Generation; 0 / Antidepressive Agents, Tricyclic; 0 / Serotonin Uptake Inhibitors
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61. Visone R, Pallante P, Vecchione A, Cirombella R, Ferracin M, Ferraro A, Volinia S, Coluzzi S, Leone V, Borbone E, Liu CG, Petrocca F, Troncone G, Calin GA, Scarpa A, Colato C, Tallini G, Santoro M, Croce CM, Fusco A: Specific microRNAs are downregulated in human thyroid anaplastic carcinomas. Oncogene; 2007 Nov 29;26(54):7590-5
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Specific microRNAs are downregulated in human thyroid anaplastic carcinomas.
  • Thyroid carcinomas comprise a broad spectrum of tumors with different clinical behaviors.
  • On the one side, there are occult papillary carcinomas (PTC), slow growing and clinically silent, and on the other side, rapidly growing anaplastic carcinomas (ATC), which are among the most lethal human neoplasms.
  • We have analysed the microRNA (miR) profile of ATC in comparison to the normal thyroid using a microarray (miRNACHIP microarray).
  • By this approach, we found an aberrant miR expression profile that clearly differentiates ATC from normal thyroid tissues and from PTC analysed in previous studies.
  • In particular, a significant decrease in miR-30d, miR-125b, miR-26a and miR-30a-5p was detected in ATC in comparison to normal thyroid tissue.
  • The overexpression of these four miRs in two human ATC-derived cell lines suggests a critical role of miR-125b and miR-26a downregulation in thyroid carcinogenesis, since a cell growth inhibition was achieved.
  • In conclusion, these data indicate a miR signature associated with ATC and suggest the miR deregulation as an important event in thyroid cell transformation.
  • [MeSH-major] Carcinoma / genetics. Chromosome Mapping. Gene Expression Regulation. MicroRNAs / genetics. Thyroid Neoplasms / genetics
  • [MeSH-minor] Cell Transformation, Neoplastic. Chromosomes, Human. Humans. RNA, Neoplasm / genetics. Reference Values. Thyroid Gland / physiology

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  • (PMID = 17563749.001).
  • [ISSN] 1476-5594
  • [Journal-full-title] Oncogene
  • [ISO-abbreviation] Oncogene
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / MIRN510 microRNA, human; 0 / MicroRNAs; 0 / RNA, Neoplasm
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62. Decoster LC, Swartz EE, Cappaert TA, Hootman JM: Prevalence and characteristics of general and football-specific emergency medical service activations by high school and collegiate certified athletic trainers: a national study. Clin J Sport Med; 2010 Nov;20(6):436-44
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prevalence and characteristics of general and football-specific emergency medical service activations by high school and collegiate certified athletic trainers: a national study.
  • OBJECTIVE: To describe frequency and characteristics of emergency medical services (EMS) activations by certified athletic trainers (ATs) and effects of pre-season planning meetings on interactions between ATs and EMS both generally and specifically during football head/neck emergencies.
  • PARTICIPANTS: Athletic trainers (n = 1884; participation rate, 28%) in high school and collegiate settings.
  • INDEPENDENT VARIABLES: Athletic trainer work setting, AT demographics, history of pre-season planning meetings.
  • CONCLUSIONS: Athletic trainer-EMS interactions are common and sometimes involve AT-perceived episodes of inappropriate care and on-field disagreements between emergency care providers.


63. Cariou JL: [Social and anthropology considerations on the composite tissues allotransplantations (CTA). Excerpts from reading and analysis of a surgeon]. Ann Chir Plast Esthet; 2007 Oct;52(5):524-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Considérations socioanthropologiques sur les allotransplantations de tissus composites (ATC). Extraits de lecture et analyse d'un chirurgien.

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  • (PMID = 17719714.001).
  • [ISSN] 0294-1260
  • [Journal-full-title] Annales de chirurgie plastique et esthétique
  • [ISO-abbreviation] Ann Chir Plast Esthet
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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64. Nijk RM, Zuidema SU, Koopmans RT: Prevalence and correlates of psychotropic drug use in Dutch nursing-home patients with dementia. Int Psychogeriatr; 2009 Jun;21(3):485-93
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Drugs were categorized according to the Anatomical Therapeutical Chemical classification (ATC).

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  • (PMID = 19368752.001).
  • [ISSN] 1041-6102
  • [Journal-full-title] International psychogeriatrics
  • [ISO-abbreviation] Int Psychogeriatr
  • [Language] ENG
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Anxiety Agents; 0 / Antidepressive Agents; 0 / Antipsychotic Agents; 0 / Hypnotics and Sedatives; 0 / Psychotropic Drugs
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65. Deters M, Prasa D, Hentschel H, Schaper A: Iatrogenic intravenous medication errors reported to the PIC Erfurt. Clin Toxicol (Phila); 2009 Feb;47(2):169-73
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  • The drug classes (ATC classification) involved most frequently were antipsychotics (9.8%) and antihistamines for systemic use (7.5%).
  • [MeSH-major] Iatrogenic Disease / epidemiology. Medication Errors. Poison Control Centers

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  • (PMID = 18608299.001).
  • [ISSN] 1556-9519
  • [Journal-full-title] Clinical toxicology (Philadelphia, Pa.)
  • [ISO-abbreviation] Clin Toxicol (Phila)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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66. Masago K, Fujita S, Irisa K, Kim YH, Ichikawa M, Mio T, Mishima M: Good clinical response to gefitinib in a non-small cell lung cancer patient harboring a rare somatic epidermal growth factor gene point mutation; codon 768 AGC &gt; ATC in exon 20 (S768I). Jpn J Clin Oncol; 2010 Nov;40(11):1105-9
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Good clinical response to gefitinib in a non-small cell lung cancer patient harboring a rare somatic epidermal growth factor gene point mutation; codon 768 AGC > ATC in exon 20 (S768I).
  • Recently, two small-molecule kinase inhibitors targeting epidermal growth factor receptor have proven effective in the treatment of non-small cell lung cancer.
  • However, it is unknown whether rare mutations in the N-lobe (exons 18-20) and the C-lobe (exon 21) of the epidermal growth factor receptor kinase domain other than L858R in exon 21 and the in-frame deletion in exon 19 may predict the effectiveness of epidermal growth factor receptor-tyrosine kinase inhibitors.
  • We reported a case of non-small cell lung cancer harboring a rare epidermal growth factor somatic mutation, codon 768 AGC > ATC in exon 20 (S768I), who showed a good clinical response to gefitinib.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Lung Neoplasms / drug therapy. Lung Neoplasms / genetics. Point Mutation / genetics. Quinazolines / therapeutic use. Receptor, Epidermal Growth Factor / genetics
  • [MeSH-minor] Aged, 80 and over. Carcinoma, Non-Small-Cell Lung / drug therapy. Carcinoma, Non-Small-Cell Lung / genetics. Carcinoma, Non-Small-Cell Lung / pathology. Exons / genetics. Humans. Male. Prognosis


67. Kopjar N, Zeljezić D, Kasuba V, Rozgaj R: [Antineoplastic drugs as a potential risk factor in occupational settings: mechanisms of action at the cell level, genotoxic effects, and their detection using different biomarkers]. Arh Hig Rada Toksikol; 2010 Mar;61(1):121-46
MedlinePlus Health Information. consumer health - Occupational Health.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Classification of antineoplastic drugs according to the IARC monographs on the evaluation of carcinogenic risks to humans is accompanied by data on their mutagenicity and the most recent updates in the Anatomical Therapeutic Chemical (ATC) Classification System.

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  • (PMID = 20338875.001).
  • [ISSN] 0004-1254
  • [Journal-full-title] Arhiv za higijenu rada i toksikologiju
  • [ISO-abbreviation] Arh Hig Rada Toksikol
  • [Language] hrv
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Croatia
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 212
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68. de With K, Meyer E, Steib-Bauert M, Schwab F, Daschner FD, Kern WV: Antibiotic use in two cohorts of German intensive care units. J Hosp Infect; 2006 Nov;64(3):231-7
MedlinePlus Health Information. consumer health - Antibiotics.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • These were the World Health Organization/Anatomical Therapeutic Chemical Classification (ATC) 2001 definition of defined daily dose (DDD), and a definition of recommended daily dose (RDD) that better reflected the currently prescribed dosages of parenteral drugs for hospitalized patients.
  • [MeSH-major] Anti-Bacterial Agents / therapeutic use. Drug Utilization Review. Intensive Care Units / statistics & numerical data. Pharmacoepidemiology

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  • (PMID = 16891039.001).
  • [ISSN] 0195-6701
  • [Journal-full-title] The Journal of hospital infection
  • [ISO-abbreviation] J. Hosp. Infect.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents
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69. Masquelet AC: [Philosophical and ethics aspects of the composite tissues allotransplantations (CTA)]. Ann Chir Plast Esthet; 2007 Oct;52(5):519-23

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Aspects éthicophilosophiques des allotransplantations de tissus composites (ATC).

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  • (PMID = 17719712.001).
  • [ISSN] 0294-1260
  • [Journal-full-title] Annales de chirurgie plastique et esthétique
  • [ISO-abbreviation] Ann Chir Plast Esthet
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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70. Pohjanoksa-Mäntylä MK, Antila J, Eerikäinen S, Enäkoski M, Hannuksela O, Pietilä K, Airaksinen M: Utilization of a community pharmacy-operated national drug information call center in Finland. Res Social Adm Pharm; 2008 Jun;4(2):144-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The majority (83%) of these calls were therapeutic or pharmaceutical inquiries, with 26% concerning costs and reimbursements, 14% interactions, 14% dosages, and 11% adverse effects.
  • Nervous system drugs (Anatomical Therapeutic Chemical [ATC] classification N), anti-infectives (J), and musculoskeletal drugs (M) accounted for 20%, 18%, and 13% of the calls, respectively.
  • Nonsteroidal anti-inflammatory drugs (NSAID) (9% of the calls), antidepressants (6%), and penicillin (5%) were the most often inquired about ATC-subgroups.
  • This may especially be the case for certain population groups, and in regard to nervous system drugs, anti-infectives and NSAID.

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  • (PMID = 18555967.001).
  • [ISSN] 1551-7411
  • [Journal-full-title] Research in social & administrative pharmacy : RSAP
  • [ISO-abbreviation] Res Social Adm Pharm
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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71. Dumartin C, L'Hériteau F, Péfau M, Bertrand X, Jarno P, Boussat S, Angora P, Lacavé L, Saby K, Savey A, Nguyen F, Carbonne A, Rogues AM: Antibiotic use in 530 French hospitals: results from a surveillance network at hospital and ward levels in 2007. J Antimicrob Chemother; 2010 Sep;65(9):2028-36
MedlinePlus Health Information. consumer health - Antibiotics.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Data were voluntarily collected retrospectively by 530 hospitals accounting for approximately 40 million patient-days (PD) on the following: antibacterials for systemic use [J01 class of the WHO Anatomical Therapeutic Chemical (ATC) classification, defined daily doses (DDD) system, 2007], rifampicin and oral imidazole derivatives, expressed in number of DDD and number of PD in 2007.
  • Penicillins and beta-lactamase inhibitors combinations were the most frequently used antibiotics, accounting for 26% of total use in cancer hospitals to 40% in LTC/psychiatric hospitals.
  • Glycopeptides and carbapenems were mostly used in cancer and teaching hospitals.
  • [MeSH-major] Anti-Bacterial Agents / therapeutic use. Drug Utilization / statistics & numerical data

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  • (PMID = 20581121.001).
  • [ISSN] 1460-2091
  • [Journal-full-title] The Journal of antimicrobial chemotherapy
  • [ISO-abbreviation] J. Antimicrob. Chemother.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents
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72. Elseviers MM, Ferech M, Vander Stichele RH, Goossens H, ESAC project group: Antibiotic use in ambulatory care in Europe (ESAC data 1997-2002): trends, regional differences and seasonal fluctuations. Pharmacoepidemiol Drug Saf; 2007 Jan;16(1):115-23
MedlinePlus Health Information. consumer health - Antibiotics.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Valid data of antibiotic consumption of 24 European countries for 2002 and of 18 countries for the entire 6-year period was classified according to the Anatomical Therapeutic Chemical Classification (ATC) and expressed in defined daily dose (DDD) per 1000 inhabitants per day (DID).
  • [MeSH-major] Ambulatory Care / methods. Ambulatory Care / statistics & numerical data. Anti-Bacterial Agents / therapeutic use. Drug Utilization Review / statistics & numerical data. Seasons
  • [MeSH-minor] Cephalosporins / therapeutic use. Drug Utilization / statistics & numerical data. Europe. Humans. Penicillins / therapeutic use. Pharmacoepidemiology / methods. Practice Patterns, Physicians' / statistics & numerical data. Quinolones / therapeutic use. Retrospective Studies. Streptogramins / therapeutic use. Time Factors

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  • [Copyright] Copyright (c) 2006 John Wiley & Sons, Ltd.
  • (PMID = 16700079.001).
  • [ISSN] 1053-8569
  • [Journal-full-title] Pharmacoepidemiology and drug safety
  • [ISO-abbreviation] Pharmacoepidemiol Drug Saf
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Cephalosporins; 0 / Penicillins; 0 / Quinolones; 0 / Streptogramins
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73. Takarabe M, Okuda S, Itoh M, Tokimatsu T, Goto S, Kanehisa M: Network analysis of adverse drug interactions. Genome Inform; 2008;20:252-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We defined drug target and drug-metabolizing enzymes as interaction factors using information on them in KEGG DRUG, and classified drugs into pharmacological/chemical subgroups.
  • To characterize other interactions without interaction factors, we used the ATC classification system and found an association between interaction mechanisms and pharmacological/chemical subgroups.

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  • (PMID = 19425139.001).
  • [ISSN] 0919-9454
  • [Journal-full-title] Genome informatics. International Conference on Genome Informatics
  • [ISO-abbreviation] Genome Inform
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Pharmaceutical Preparations; 0 / Receptors, Biogenic Amine; EC 1.14.14.1 / Cytochrome P-450 CYP3A
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74. Usher C, Teeling M, Bennett K, Feely J: Effect of clinical trial publicity on HRT prescribing in Ireland. Eur J Clin Pharmacol; 2006 Apr;62(4):307-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Prescriptions were identified for HRT and bisphosphonate preparations [using WHO Anatomical Therapeutic Chemical (ATC) classification codes] in female patients aged 45-69 years in Ireland during a 4-year study period (January 2001-December 2004).
  • [MeSH-minor] Aged. Diphosphonates / therapeutic use. Female. Humans. Ireland. Middle Aged. Osteoporosis / drug therapy

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  • (PMID = 16432715.001).
  • [ISSN] 0031-6970
  • [Journal-full-title] European journal of clinical pharmacology
  • [ISO-abbreviation] Eur. J. Clin. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Diphosphonates
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75. Lin SF, Xiao KT, Huang YT, Chiu CC, Soo VW: Analysis of adverse drug reactions using drug and drug target interactions and graph-based methods. Artif Intell Med; 2010 Feb-Mar;48(2-3):161-6
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The goals were to build a system facilitating the study of adverse drug events, to make it easier to find possible explanations, and to group similar drug-drug interaction cases in the adverse drug reaction reports from the US Food and Drug Administration (FDA).
  • METHODS: We developed a system that analyses adverse drug reaction (ADR) cases reported by the FDA.
  • The system contains four modules.
  • Second, we classify drug and drug targets according to anatomical therapeutic chemical classification (ATC) and drug target ontology (DTO).
  • We then investigated the cases involving ADR targets, ADME targets, and CTs using the ATC system and DTO.
  • CONCLUSIONS: We implemented a system that can find possible explanations and cluster similar ADR cases reported by the FDA.
  • This indicates that our system can help not only in analysing ADRs in terms of drug-drug interactions but also by providing drug target assessments early in the drug discovery process.

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  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
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  • [Copyright] 2009 Elsevier B.V. All rights reserved.
  • (PMID = 19962282.001).
  • [ISSN] 1873-2860
  • [Journal-full-title] Artificial intelligence in medicine
  • [ISO-abbreviation] Artif Intell Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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76. de Oliveira Martins S, Soares MA, Foppe van Mil JW, Cabrita J: Inappropriate drug use by Portuguese elderly outpatients--effect of the Beers criteria update. Pharm World Sci; 2006 Oct;28(5):296-301

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The drugs were distributed mainly in the following 3 ATC (Anatomical Therapeutic Chemical Classification) classes: C (cardiovascular system), N (nervous system) and A (alimentary tract).
  • According to the ATC Classification, more than one half of the cases of inappropriateness were related with long acting benzodiazepines and with ticlopidine.

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  • (PMID = 17111245.001).
  • [ISSN] 0928-1231
  • [Journal-full-title] Pharmacy world & science : PWS
  • [ISO-abbreviation] Pharm World Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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77. Heinemeyer G, Hahn A: Use of product databases for risk assessment purposes. Toxicol Appl Pharmacol; 2005 Sep 1;207(2 Suppl):636-44

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The first system that has been prepared for that purpose is the ATC classification for pharmaceuticals.
  • For chemicals, several systems e.g. the WHO-IPCS classification code, exist; the EU technical guidance document for risk assessment of chemicals is mentioning use categories, and they are used on national levels as well.

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  • (PMID = 15979672.001).
  • [ISSN] 1096-0333
  • [Journal-full-title] Toxicology and applied pharmacology
  • [ISO-abbreviation] Toxicol. Appl. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 19
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78. Frost Widnes SK, Schjøtt J: Advice on drug safety in pregnancy: are there differences between commonly used sources of information? Drug Saf; 2008;31(9):799-806
MedlinePlus Health Information. consumer health - Drug Reactions.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Inconsistencies between sources providing drug information can give rise to confusion with possible therapeutic consequences.
  • The objective of this study was to compare two easily accessible Norwegian sources providing advice on drug safety in pregnancy - the product monographs in the Felleskatalog (FK), published by the pharmaceutical companies, and the five regional Drug Information Centres (DICs) in Norway - in addition to assessing the frequency of questions regarding drug safety in pregnancy made to the DICs according to the Anatomical Therapeutic Chemical (ATC) classification system.
  • Seven out of ten of drugs frequently enquired about, according to the ATC system, were drugs acting on the nervous system (group N).
  • [MeSH-minor] Drug Labeling. Female. Humans. Norway. Pharmaceutical Preparations / classification. Pilot Projects. Pregnancy. Pregnancy Trimesters. Risk Assessment

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  • (PMID = 18707194.001).
  • [ISSN] 0114-5916
  • [Journal-full-title] Drug safety
  • [ISO-abbreviation] Drug Saf
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] New Zealand
  • [Chemical-registry-number] 0 / Pharmaceutical Preparations
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79. Närhi U, Vanakoski J, Sihvo S: Switching of H(2)-Receptor Antagonists to Over-the-Counter Status in Finland : Implications for Consumption and Adverse Effects. Clin Drug Investig; 2005;25(4):243-8
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We studied the consumption of H(2)-receptor antagonists, proton pump inhibitors, sucralfate and antacids (A02BA, A02BC, A02BX02 and A02A, respectively, according to the Anatomical Therapeutic Chemical [ATC] classification).
  • RESULTS: The total consumption of medicines for the treatment of peptic ulcer disease and gastro-oesophageal reflux disease increased more than 2-fold from 1990 to 2003 (from 12.8 daily defined doses [DDD]/1000 inhabitants/day to 29.6 DDD/1000 inhabitants/day).
  • Since 1998, proton pump inhibitors have been the most commonly used drug group for the treatment of peptic ulcer and gastro-oesophageal reflux disease in Finland.
  • In 2003, the consumption of proton pump inhibitors was 75% (22.2 DDD/1000 inhabitants/day) of the total consumption of drugs for the treatment of peptic ulcer and gastro-oesophageal reflux disease.
  • However, the total number of reports concerning these ATC groups in the national ADR database is not very high, and therefore patient-based surveys are needed to verify this finding.

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  • (PMID = 17523774.001).
  • [ISSN] 1173-2563
  • [Journal-full-title] Clinical drug investigation
  • [ISO-abbreviation] Clin Drug Investig
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] New Zealand
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80. Gedde-Dahl A, Harg P, Stenberg-Nilsen H, Buajordet M, Granas AG, Horn AM: Characteristics and quality of adverse drug reaction reports by pharmacists in Norway. Pharmacoepidemiol Drug Saf; 2007 Sep;16(9):999-1005
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: To evaluate the characteristics and quality of adverse drug reaction (ADR) reports submitted by pharmacists, and thereby assess the possible contribution of pharmacists to the spontaneous reporting system for ADRs in Norway.
  • All reports were evaluated for selected characteristics, that is distribution of Anatomical Therapeutic Chemical (ATC) classification codes of suspected drugs, distribution of ADRs according to system-organ classes and the quality of the reports.
  • ADRs reported by pharmacists more frequently described gastrointestinal reactions while physicians reported more ADRs in relation to the cardiovascular and blood system.
  • This emphasises that pharmacist ADR reporting might constitute an important addition to the spontaneous reporting system.

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  • [Copyright] Copyright (c) 2007 John Wiley & Sons, Ltd.
  • (PMID = 17457794.001).
  • [ISSN] 1053-8569
  • [Journal-full-title] Pharmacoepidemiology and drug safety
  • [ISO-abbreviation] Pharmacoepidemiol Drug Saf
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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81. Goh LY, Vitry AI, Semple SJ, Esterman A, Luszcz MA: Self-medication with over-the-counter drugs and complementary medications in South Australia's elderly population. BMC Complement Altern Med; 2009 Nov 11;9:42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OTC medicines were classified according to the World Health Organization Anatomical Therapeutic Chemical (ATC) classification.
  • CAM were classified according a modified version of the classification adopted by the Therapeutics Goods Administration (TGA) in Australia.

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  • [Cites] J Am Geriatr Soc. 2000 Dec;48(12):1560-5 [11129743.001]
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  • (PMID = 19906314.001).
  • [ISSN] 1472-6882
  • [Journal-full-title] BMC complementary and alternative medicine
  • [ISO-abbreviation] BMC Complement Altern Med
  • [Language] ENG
  • [Grant] United States / NIA NIH HHS / AG / AG08523-02
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Analgesics; 0 / Laxatives; 0 / Nonprescription Drugs; R16CO5Y76E / Aspirin
  • [Other-IDs] NLM/ PMC2778637
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82. Quintana VO, Deniz ES, Ortega FD, Ramírez SD, Pita JM, Castro Ade L: [Antibiotic use in the pediatric population: factors to consider]. Rev Esp Quimioter; 2007 Dec;20(4):409-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Factores a considerar en el análisis de la prescripción de antibióticos en pediatría.
  • We used the defined daily dose (DDD) as a technical unit of measurement as well as the DDD/1000 habitants/day (DHD), following the ATC classification system.
  • In analyzing the therapeutic classes of antibiotics, we found that the consumption of broad-spectrum penicillins (amoxicillin) in Tenerife decreased, while in Las Palmas it remained stable.
  • [MeSH-major] Anti-Bacterial Agents / therapeutic use

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  • (PMID = 18563214.001).
  • [ISSN] 0214-3429
  • [Journal-full-title] Revista española de quimioterapia : publicación oficial de la Sociedad Española de Quimioterapia
  • [ISO-abbreviation] Rev Esp Quimioter
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents
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83. Zargarzadeh AH, Emami MH, Hosseini F: Drug-related hospital admissions in a generic pharmaceutical system. Clin Exp Pharmacol Physiol; 2007 May-Jun;34(5-6):494-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Drug-related hospital admissions in a generic pharmaceutical system.
  • Medications responsible for DRP were classified according to the Anatomic Therapeutic Chemical (ATC) classification of the World Health Organization.

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  • (PMID = 17439421.001).
  • [ISSN] 0305-1870
  • [Journal-full-title] Clinical and experimental pharmacology & physiology
  • [ISO-abbreviation] Clin. Exp. Pharmacol. Physiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Drugs, Generic
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84. Hadjimichael C, Georgiou K, Samoutis G, Demetriades E: Sales of systemic anti-infective agents in Cyprus in comparison with four other European countries. Pharm World Sci; 2006 Jun;28(3):135-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHOD: The Anatomical Therapeutic Chemical (ATC) classification and the Defined Daily Dose (DDD) methodology according to the WHO (World Health Organization) guidelines were employed and data in wholesales were used.

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  • (PMID = 17004026.001).
  • [ISSN] 0928-1231
  • [Journal-full-title] Pharmacy world & science : PWS
  • [ISO-abbreviation] Pharm World Sci
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Anti-Infective Agents
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85. Milder IE, Klungel OH, Mantel-Teeuwisse AK, Verschuren WM, Bemelmans WJ: Relation between body mass index, physical inactivity and use of prescription drugs: the Doetinchem Cohort Study. Int J Obes (Lond); 2010 Jun;34(6):1060-9
MedlinePlus Health Information. consumer health - Smoking.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Obesity and physical inactivity are associated with several diseases such as diabetes, cardiovascular diseases, musculoskeletal complaints, osteoporosis, certain types of cancer and depression.
  • Drugs were coded according to the WHO Anatomical Therapeutic Chemical (ATC) classification system.
  • Persons were defined as a user of a certain drug class if they filed at least one prescription in the year around (+/-6 months) the examination.
  • [MeSH-major] Body Mass Index. Obesity / complications. Prescription Drugs / therapeutic use. Sedentary Lifestyle. Smoking

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  • (PMID = 20125097.001).
  • [ISSN] 1476-5497
  • [Journal-full-title] International journal of obesity (2005)
  • [ISO-abbreviation] Int J Obes (Lond)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Prescription Drugs
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86. Metz-Gercek S, Maieron A, Strauss R, Wieninger P, Apfalter P, Mittermayer H: Ten years of antibiotic consumption in ambulatory care: trends in prescribing practice and antibiotic resistance in Austria. BMC Infect Dis; 2009;9:61
MedlinePlus Health Information. consumer health - Antibiotics.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: The primary aims of this study were (i) to determine the quantity and pattern of antibiotic use in Austria between 1998 and 2007 and (ii) to analyze antibiotic esistance rates in relation to antibiotic consumption in important clinical situations in order to provide data for empirical therapeutic regimens for key indications.
  • METHODS: Consumption data and resistance data were obtained via the Austrian surveillance networks European Antimicrobial Resistance Surveillance System (EARSS) and European Surveillance on Antimicrobial Consumption (ESAC).
  • The Anatomical Therapeutic Chemical (ATC) classification and the Defined Daily Dose (DDD) measurement units were assigned to the data.
  • The percentage of nonsusceptible or intermediate penicillin-resistant pneumococcal isolates remained stable over this time period at around 5%.
  • [MeSH-major] Ambulatory Care / trends. Anti-Bacterial Agents / therapeutic use. Drug Resistance, Bacterial. Practice Patterns, Physicians' / trends. Prescriptions / statistics & numerical data

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  • [Cites] Clin Microbiol Infect. 2000 Feb;6(2):59-63 [11168073.001]
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  • (PMID = 19439064.001).
  • [ISSN] 1471-2334
  • [Journal-full-title] BMC infectious diseases
  • [ISO-abbreviation] BMC Infect. Dis.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents
  • [Other-IDs] NLM/ PMC2686702
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87. Fagnoni P, Limat S, Haffen E, Henon T, Jacquet M, Sechter D, Woronoff-Lemsi MC: Does hospitalisation affect hypnotic and anxiolytic drug prescribing? Pharm World Sci; 2007 Dec;29(6):611-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The HA drug list studied was selected using the World Health Organisation (WHO) Anatomical Therapeutic and Chemical (ATC) classification system.
  • 48% (n = 260), 64% (n = 260) and 58% (n = 112) of the included patients had sleep disorder complaints respectively before, during and after hospitalisation.
  • Our results should incite hospital prescribers to transversally reconsider the whole sleep disorder treatment strategy in hospital settings, from improving patient's accommodation conditions, to working out a consensus on the justification of prescription of HA and precising the exact place of nursing team in sleep disorders management.
  • [MeSH-major] Anti-Anxiety Agents / therapeutic use. Hospitalization. Hypnotics and Sedatives / therapeutic use

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  • (PMID = 17370138.001).
  • [ISSN] 0928-1231
  • [Journal-full-title] Pharmacy world & science : PWS
  • [ISO-abbreviation] Pharm World Sci
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Anti-Anxiety Agents; 0 / Hypnotics and Sedatives
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88. Aagaard L, Weber CB, Hansen EH: Adverse drug reactions in the paediatric population in Denmark: a retrospective analysis of reports made to the Danish Medicines Agency from 1998 to 2007. Drug Saf; 2010 Apr 1;33(4):327-39
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Data were analysed with respect to time, age and sex, category of ADR (System Organ Class [SOC]), seriousness, suspected medicines (level 2 of the Anatomical Therapeutic Chemical [ATC] Classification System) and type of reporter.
  • The majority of ADRs reported were from the following SOCs: general disorders and administration site conditions (31%), skin and subcutaneous tissue disorders (18%) and nervous system disorders (15%).
  • Reports encompassed medicines from ATC group J: vaccines and anti-infectives for systemic use (65%); and ATC group N: nervous system (17%).
  • ATC group N had the highest proportion of ADRs that were classified as serious.
  • The majority of ADRs reported in young children were reported for vaccines and anti-infectives, but also a high number of serious ADRs were reported for medicines from ATC group N.

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  • (PMID = 20297864.001).
  • [ISSN] 1179-1942
  • [Journal-full-title] Drug safety
  • [ISO-abbreviation] Drug Saf
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] New Zealand
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89. Stiller-Ostrowski JL, Ostrowski JA: Recently certified athletic trainers' undergraduate educational preparation in psychosocial intervention and referral. J Athl Train; 2009 Jan-Feb;44(1):67-75
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recently certified athletic trainers' undergraduate educational preparation in psychosocial intervention and referral.
  • CONTEXT: "Psychosocial Intervention and Referral" is one of the 12 content areas established by the National Athletic Trainers' Association Education Council and is required to be taught in athletic training education programs (ATEPs).
  • The perceived preparation of athletic trainers (ATs) in this content area has not been evaluated.
  • OBJECTIVE: To explore the preparation level of recently certified ATs within the content area of "Psychosocial Intervention and Referral."
  • SETTING: Interviews were conducted at 2 National Collegiate Athletic Association Division I institutions in 2 regions of the United States.
  • PATIENTS OR OTHER PARTICIPANTS: A total of 11 recently certified ATs who met predetermined criteria were recruited.
  • CONCLUSIONS: Limitations of undergraduate ATEPs regarding preparation of athletic training students within the "Psychosocial Intervention and Referral" content area were identified, with the goal of improving athletic training education.
  • The more we know about the issues that entry-level ATs face, the more effectively we can structure athletic training education.

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  • (PMID = 19180221.001).
  • [ISSN] 1938-162X
  • [Journal-full-title] Journal of athletic training
  • [ISO-abbreviation] J Athl Train
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2629042
  • [Keywords] NOTNLM ; competencies / proficiencies / qualitative research
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90. James TH, Helms ML, Braund R: Analysis of medications returned to community pharmacies. Ann Pharmacother; 2009 Oct;43(10):1631-5
MedlinePlus Health Information. consumer health - Medicines.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To identify and quantify the types and amounts of medications returned to community pharmacies and, specifically, to quantify the percentage of medication returned from the original dispensing, its therapeutic category, and reasons for not being used.
  • The results were entered into a database, recording medication, amount originally issued (if known), date of issue, Anatomical Therapeutic Chemical (ATC) classification, and reason for nonuse.
  • Cross-tabulation of ATC category versus percentage returned as well as ATC category versus reason for returns was performed.
  • For the respiratory category, 77% of the returns were in the 75-100% group, significantly more than for any other therapeutic group.
  • Identification of therapeutic groups having higher rates of returns due to medication changes or surplus to requirements may suggest areas to target to reduce medication waste.

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  • (PMID = 19776296.001).
  • [ISSN] 1542-6270
  • [Journal-full-title] The Annals of pharmacotherapy
  • [ISO-abbreviation] Ann Pharmacother
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Pharmaceutical Preparations
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91. Cahir C, Fahey T, Teeling M, Teljeur C, Feely J, Bennett K: Potentially inappropriate prescribing and cost outcomes for older people: a national population study. Br J Clin Pharmacol; 2010 May;69(5):543-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The HSE-PCRS uses the WHO Anatomical Therapeutic Chemical (ATC) classification system and details of every drug dispensed and claimants' demographic data are available.
  • STOPP is a physiological system based screening tool of older persons' potentially inappropriate prescriptions assessing drug-drug and drug-disease interactions, dose and duration.
  • The main contributors to this were: 56 560 (17%) prescribed proton pump inhibitors at maximum therapeutic dose for >8 weeks, 29 691 (9%) prescribed non-steroidal anti-inflammatories for >3 months, 17 676 (5%) prescribed long-acting benzodiazepines for >1 month and 16 201 (5%) prescribed duplicate drugs.

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  • (PMID = 20573091.001).
  • [ISSN] 1365-2125
  • [Journal-full-title] British journal of clinical pharmacology
  • [ISO-abbreviation] Br J Clin Pharmacol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2856056
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92. Nor Aripin KN, Sammons HM, Choonara I: Published pediatric randomized drug trials in developing countries, 1996-2002. Paediatr Drugs; 2010 Apr 1;12(2):99-103
ClinicalTrials.gov. clinical trials - ClinicalTrials.gov .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: The greatest burden of disease in children lies in the developing world; however, previous reviews have suggested that few randomized controlled trials (RCTs) involving children take place in developing countries.
  • OBJECTIVE: To elucidate published pediatric therapeutic RCTs that have taken place in the developing world and to determine whether they are appropriate for the major diseases occurring there, and to explore their approach to safety monitoring.
  • Articles were read to add the WHO International Classification of Diseases 10th Revision (ICD-10) category of the disease studied, the WHO Collaborating Centre for Drug Statistics Methodology Anatomical Therapeutic Chemical (ATC) classification system category of the main drug therapy studied, the source of funding, and ethical approval to the variables already recorded in the database.
  • The disease areas studied seemed appropriate, with 89 (56%) of the 158 RCTs studying infectious and parasitic diseases.
  • [MeSH-minor] Child. Developing Countries. Human Development. Humans. International Classification of Diseases. MEDLINE. Pharmaceutical Preparations / administration & dosage. World Health Organization

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  • (PMID = 20218746.001).
  • [ISSN] 1179-2019
  • [Journal-full-title] Paediatric drugs
  • [ISO-abbreviation] Paediatr Drugs
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] New Zealand
  • [Chemical-registry-number] 0 / Pharmaceutical Preparations
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93. Olivier P, Bertrand L, Tubery M, Lauque D, Montastruc JL, Lapeyre-Mestre M: Hospitalizations because of adverse drug reactions in elderly patients admitted through the emergency department: a prospective survey. Drugs Aging; 2009;26(6):475-82
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The most important factors associated with ADRs were the number of drugs being taken (odds ratio [OR] 1.18; 95% CI 1.08, 1.29), self-medication (OR 2.34; 95% CI 1.18, 4.66), use of antithrombotics (Anatomic Therapeutic and Chemical [ATC] classification B01; OR 2.26; 95% CI 1.33, 3.88) and use of antibacterial drugs (ATC J01; OR 4.04; 95% CI 1.50, 10.83).

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  • (PMID = 19591522.001).
  • [ISSN] 1170-229X
  • [Journal-full-title] Drugs & aging
  • [ISO-abbreviation] Drugs Aging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] New Zealand
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Anticoagulants
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94. Kjoenniksen I, Lindbaek M, Granas AG: Patients' attitudes towards and experiences of generic drug substitution in Norway. Pharm World Sci; 2006 Oct;28(5):284-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Prescriptions from 2,128 consecutive patients in a Norwegian pharmacy were retrospectively reviewed to identify all patients (n=274) receiving eight or more different prescription drugs on the fifth level in the Anatomical Therapeutic Chemical (ATC) classification system during the last 6 months.

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  • (PMID = 17111247.001).
  • [ISSN] 0928-1231
  • [Journal-full-title] Pharmacy world & science : PWS
  • [ISO-abbreviation] Pharm World Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Drugs, Generic
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95. Salvatore G, Nappi TC, Salerno P, Jiang Y, Garbi C, Ugolini C, Miccoli P, Basolo F, Castellone MD, Cirafici AM, Melillo RM, Fusco A, Bittner ML, Santoro M: A cell proliferation and chromosomal instability signature in anaplastic thyroid carcinoma. Cancer Res; 2007 Nov 1;67(21):10148-58
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A cell proliferation and chromosomal instability signature in anaplastic thyroid carcinoma.
  • Here, we show that the anaplastic thyroid carcinoma (ATC) features the up-regulation of a set of genes involved in the control of cell cycle progression and chromosome segregation.
  • This phenotype differentiates ATC from normal tissue and from well-differentiated papillary thyroid carcinoma.
  • Transcriptional promoters of the ATC up-regulated genes are characterized by a modular organization featuring binding sites for E2F and NF-Y transcription factors and cell cycle-dependent element (CDE)/cell cycle gene homology region (CHR) cis-regulatory elements.
  • Two protein kinases involved in cell cycle regulation, namely, Polo-like kinase 1 (PLK1) and T cell tyrosine kinase (TTK), are part of the gene set that is up-regulated in ATC.
  • Adoptive overexpression of p53, p21 (CIP1/WAF1), and E2F4 down-regulated transcription from the PLK1 and TTK promoters in ATC cells, suggesting that these genes might be under the negative control of tumor suppressors of the p53 and pRB families.
  • ATC, but not normal thyroid, cells depended on PLK1 for survival.
  • Thus, thyroid cell anaplastic transformation is accompanied by the overexpression of a cell proliferation/genetic instability-related gene cluster that includes PLK1 kinase, which is a potential molecular target for ATC treatment.
  • [MeSH-major] Carcinoma / genetics. Chromosomal Instability. Thyroid Neoplasms / genetics

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  • (PMID = 17981789.001).
  • [ISSN] 1538-7445
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cell Cycle Proteins; 0 / Proto-Oncogene Proteins; 0 / Tumor Suppressor Protein p53; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; EC 2.7.11.1 / polo-like kinase 1; EC 2.7.12.1 / TTK protein, human
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96. Balkrishnan R, Phatak H, Gleim G, Karve S: Assessment of the use of angiotensin receptor blockers in major European markets among paediatric population for treating essential hypertension. J Hum Hypertens; 2009 Jun;23(6):420-5
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Paediatric patients with essential hypertension were identified using ICD-10 codes, and anatomical therapeutic chemical (ATC) classification was used to identify major classes of antihypertensives.
  • [MeSH-major] Angiotensin II Type 1 Receptor Blockers / therapeutic use. Hypertension / drug therapy. Practice Patterns, Physicians'

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  • (PMID = 19052566.001).
  • [ISSN] 1476-5527
  • [Journal-full-title] Journal of human hypertension
  • [ISO-abbreviation] J Hum Hypertens
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Angiotensin II Type 1 Receptor Blockers; 0 / Drug Combinations
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97. Steyn K, Bradshaw D, Norman R, Bradley H, Laubscher R, Research team of the South African Demographic and Health Survey: The use of prescribed drugs for common chronic conditions in South Africa in 1998. Pharmacoepidemiol Drug Saf; 2005 Feb;14(2):91-100
MedlinePlus Health Information. consumer health - Coping with Chronic Illness.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Questionnaires included socio-demographic, chronic-disease and drug-use data.
  • The Anatomical Therapeutic Classification (ATC) code of the drugs for tuberculosis (TB), diabetes, hypertension, hyperlipidaemia, other atherosclerosis-related conditions, such as heart conditions or cerebrovascular accidents (CVA), and asthma or chronic obstructive pulmonary disease (COPD), was recorded.
  • The logistic regression analyses showed that women, wealthier and older people, and those with medical insurance used these chronic-disease drugs more frequently compared to men, younger or poor people, or those without medical insurance.
  • CONCLUSIONS: The methodology of this study provides a means of ascertaining the chronic-disease drug-utilisation pattern in national health surveys.
  • The pattern described, suggests an inequitable use of chronic-disease drugs and inadequate use of some effective drugs to control the burden of chronic diseases in South Africa.
  • [MeSH-major] Chronic Disease / drug therapy

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  • (PMID = 15624195.001).
  • [ISSN] 1053-8569
  • [Journal-full-title] Pharmacoepidemiology and drug safety
  • [ISO-abbreviation] Pharmacoepidemiol Drug Saf
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
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98. Takano T, Ito Y, Matsuzuka F, Miya A, Kobayashi K, Yoshida H, Miyauchi A: Expression of oncofetal fibronectin mRNA in thyroid anaplastic carcinoma. Jpn J Clin Oncol; 2007 Sep;37(9):647-51
MedlinePlus Health Information. consumer health - Thyroid Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of oncofetal fibronectin mRNA in thyroid anaplastic carcinoma.
  • BACKGROUND: Oncofetal fibronectin (onfFN) is a fetal protein, the expression of which is observed in papillary thyroid carcinomas but not in follicular tumors or in normal thyroid.
  • Its expression in anaplastic thyroid carcinoma (ATC), however, has not been clarified, since only a few cases had been examined in previous studies.
  • METHODS: We examined the expression levels of onfFN mRNA in ATC tissues and cell lines derived from ATC by real-time quantitative reverse transcription-polymerase chain reaction (PCR) and in situ hybridization.
  • RESULTS: Increased expression of onfFN mRNA was observed in all cases of ATC regardless of the type of accompanying differentiated carcinoma and five of six ATC cell lines.
  • Furthermore, expression of onfFN mRNA was observed in the majority of ATC cells in all six tissues examined by in situ hybridization.
  • CONCLUSION: These results confirm that expression of onfFN mRNA characterizes not only papillary thyroid carcinoma but also ATC. onfFN mRNA or protein may be a useful marker to identify anaplastic carcinoma cells and may be considered as an optimistic target in molecular-based therapy of ATC.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma / chemistry. Fibronectins / analysis. Thyroid Gland / chemistry. Thyroid Neoplasms / chemistry

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  • (PMID = 17704536.001).
  • [ISSN] 1465-3621
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Fibronectins; 0 / RNA, Messenger; 0 / oncofetal fibronectin
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99. Libertini S, Iacuzzo I, Ferraro A, Vitale M, Bifulco M, Fusco A, Portella G: Lovastatin enhances the replication of the oncolytic adenovirus dl1520 and its antineoplastic activity against anaplastic thyroid carcinoma cells. Endocrinology; 2007 Nov;148(11):5186-94
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Lovastatin enhances the replication of the oncolytic adenovirus dl1520 and its antineoplastic activity against anaplastic thyroid carcinoma cells.
  • Anaplastic thyroid carcinoma (ATC) is one of the most aggressive solid tumors and shows morphological features of a highly malignant, undifferentiated neoplasm.
  • Patients with ATC have a poor prognosis with a mean survival time of 2-6 months; surgery, radiotherapy, and chemotherapy do not improve survival.
  • Gene therapy approaches and oncolytic viruses have been tested for the treatment of ATC.
  • To enhance the antineoplastic effects of the oncolytic adenovirus dl1520 (Onyx-015), we treated ATC cells with lovastatin (3-hydroxy-methylglutaryl-CoA reductase inhibitor), a drug used for the treatment of hypercholesterolemia, which has previously been reported to exert growth-inhibitory and apoptotic activity on ATC cells.
  • Lovastatin treatment significantly increased the effects of dl1520 against ATC cells.
  • The replication of dl1520 in ATC cells was enhanced by lovastatin treatment, and a significant increase of the expression of the early gene E1A 13 S and the late gene Penton was observed in lovastatin-treated cells.
  • Furthermore, lovastatin treatment significantly enhanced the effects of dl1520 against ATC tumor xenografts.
  • Lovastatin treatment could be exploited to increase the efficacy of oncolytic adenoviruses, and further studies are warranted to confirm the feasibility of the approach in ATC patients.
  • [MeSH-major] Adenoviridae / drug effects. Antineoplastic Agents / therapeutic use. Carcinoma / therapy. Lovastatin / pharmacology. Lovastatin / therapeutic use. Oncolytic Virotherapy. Thyroid Neoplasms / therapy. Virus Replication / drug effects

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  • Hazardous Substances Data Bank. LOVASTATIN .
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  • (PMID = 17690162.001).
  • [ISSN] 0013-7227
  • [Journal-full-title] Endocrinology
  • [ISO-abbreviation] Endocrinology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / ONYX015; 0 / Viral Vaccines; 9LHU78OQFD / Lovastatin
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100. Rossi E, Crudeli L, Endrizzi C, Garibaldi D: Cost-benefit evaluation of homeopathic versus conventional therapy in respiratory diseases. Homeopathy; 2009 Jan;98(1):2-10

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: A retrospective observational study was conducted on 105 out of 233 patients suffering from chronic respiratory disease attending the Homeopathic Clinic of the Campo di Marte Hospital in Lucca (Tuscany, Italy) between October 1998 and May 2003.
  • We assessed the cost of conventional medicinal products using Anatomic Therapeutic Chemical (ATC) classification, specific for the pathology in question, and the general costs in the year preceding the first appointment at the Homeopathic Clinic vs. the first and second year subsequent to homeopathic treatment.

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  • (PMID = 19135953.001).
  • [ISSN] 1476-4245
  • [Journal-full-title] Homeopathy : the journal of the Faculty of Homeopathy
  • [ISO-abbreviation] Homeopathy
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Scotland
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