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1. Vilar VJ, Maldonado MI, Oller I, Malato S, Boaventura RA: Solar treatment of cork boiling and bleaching wastewaters in a pilot plant. Water Res; 2009 Sep;43(16):4050-62
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  • According to the average oxidation state (AOS), toxicity profiles, respirometry and kinetic results obtained in two solar CPCs plants, the optimal energy dose estimated for phototreatment to reach a biodegradable effluent is 15 kJ(UV)/L and 114 kJ(UV)/L, consuming 33 mM and 151 mM of H(2)OT:/PGN/ELSEVIER/WR/web/00007490/(2), achieving almost 49% and 48% mineralization of the wastewaters, respectively for the cork bleaching and boiling wastewaters.

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  • (PMID = 19577272.001).
  • [ISSN] 1879-2448
  • [Journal-full-title] Water research
  • [ISO-abbreviation] Water Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Fenton's reagent; 0 / Industrial Waste; 0 / Water Pollutants; 059QF0KO0R / Water; 15FIX9V2JP / titanium dioxide; BBX060AN9V / Hydrogen Peroxide; D1JT611TNE / Titanium; E1UOL152H7 / Iron
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2. Fouladi M, Gururangan S, Moghrabi A, Phillips P, Gronewold L, Wallace D, Sanford RA, Gajjar A, Kun LE, Heideman R: Carboplatin-based primary chemotherapy for infants and young children with CNS tumors. Cancer; 2009 Jul 15;115(14):3243-53
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  • METHODS: Fifty-three patients aged <age 3 years with embryonal CNS tumor medulloblastoma (n = 20), ependymoma (EP, n = 21), choroid plexus carcinoma (CPCA, n = 5), and primitive embryonal neoplasms including atypical teratoid rhabdoid tumors (n = 7) were treated with cyclophosphamide, etoposide, and carboplatin.

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  • (PMID = 19484793.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA021765; United States / NCI NIH HHS / CA / P30 CA021765-30; United States / NCI NIH HHS / CA / R25 CA023944; United States / NCI NIH HHS / CA / CA21765
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 6PLQ3CP4P3 / Etoposide; 8N3DW7272P / Cyclophosphamide; BG3F62OND5 / Carboplatin
  • [Other-IDs] NLM/ NIHMS124374; NLM/ PMC4307774
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3. Lescanne E, François P, Velut S: Cerebellopontine cistern: microanatomy applied to vestibular schwannomas. Prog Neurol Surg; 2008;21:43-53
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  • The microanatomy of the cerebellopontine cistern (CPC) is of interest to many surgeons and has been the subject of controversial works especially concerning the study of the subarachnoid space in the internal acoustic meatus (IAM).
  • The CPC lies in the cerebellopontine angle between the brainstem, cerebellum and petrous bone.
  • The acousticofacial cistern is a lateral extension of the CPC in the IAM.

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  • (PMID = 18810198.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 39
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4. Lee LC, Chen CS, Choong PF, Low A, Tan HC, Poh KK: Time-dependent dynamic mobilization of circulating progenitor cells during percutaneous coronary intervention in diabetics. Int J Cardiol; 2010 Jul 9;142(2):199-201
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  • BACKGROUND: Circulating progenitor cells (CPC) especially endothelial progenitor cell (EPC) levels and functions are attenuated in diabetic patients.
  • RESULTS: After PCI, decreases in CPC from baseline were detected in 7 out of the 8 patients.
  • At 24 h, CPC levels returned to baseline but were not elevated.
  • The only patient with raised cardiac enzymes has instead, 2 to 3 fold increase in CPCs at 1 and 4 h.
  • The absence of subsequent CPC elevation post-PCI in diabetes may be associated with known poorer outcome of these patients.

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  • [Copyright] Copyright (c) 2008 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 19157595.001).
  • [ISSN] 1874-1754
  • [Journal-full-title] International journal of cardiology
  • [ISO-abbreviation] Int. J. Cardiol.
  • [Language] eng
  • [Publication-type] Comparative Study; Letter
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antigens, CD34
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5. Zhao Q, Yang K, Li P: Enhanced soil retention for o-nitroaniline by the addition of a mixture of a cationic surfactant (Cetyl Pyridinium Chloride) and a nonionic surfactant (Polyethylene Glycol Mono-4-nonylphenyl Ether). J Hazard Mater; 2010 Oct 15;182(1-3):757-62
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  • The sorption enhancement of o-nitroaniline on a soil by the addition of a mixture of a cationic surfactant (Cetyl Pyridinium Chloride, CPC) and a nonionic surfactant (Polyethylene Glycol Mono-4-nonylphenyl Ether, P0707), as compared with that by individual CPC and P0707, was investigated to examine their potential application in soil retarding for organic contaminants.
  • The maximum sorption coefficients (K(d)(*)) of o-nitroaniline on modified soils by individual CPC and P0707 were 110 mL g(-1) at an added CPC dose of 6000 mg L(-1) and 12.5 mL g(-1) at an added P0707 dose of 7000 mg L(-1), respectively.
  • They were approximately 78 and 8.87 times higher than the sorption coefficients (K(d)) of o-nitroaniline on the un-modified soil (1.41 mL g(-1)), suggesting that CPC and P0707 can enhance the sorptive capacity of soil for o-nitroaniline.
  • The maximum K(d)(*) value of o-nitroaniline on modified soils by the mixture of CPC and P0707 was 144 mg L(-1) (at CPC dose of 10,500 mg L(-1) and P0707 dose of 6000 mg L(-1)), which is higher than that on the CPC (or P0707) modified soils and approximately 102 times higher than that on the un-modified soil.

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  • [Copyright] 2010 Elsevier B.V. All rights reserved.
  • (PMID = 20638783.001).
  • [ISSN] 1873-3336
  • [Journal-full-title] Journal of hazardous materials
  • [ISO-abbreviation] J. Hazard. Mater.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Aniline Compounds; 0 / Soil Pollutants; 0 / Surface-Active Agents; 29757-24-2 / nitroaniline
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6. Li Y, Qu J, Shelat H, Gao S, Wassler M, Geng YJ: Clusterin induces CXCR4 expression and migration of cardiac progenitor cells. Exp Cell Res; 2010 Dec 10;316(20):3435-42
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  • This study aimed at testing whether CST enhances expression of stem cell homing receptor and migration of cardiac progenitor cells (CPCs).
  • CPCs isolated from fetal canine hearts transduced by CST cDNA expressed high levels of CXCR4, a receptor for SDF-1.
  • The SDF-1-mediated migration of the CST-expressing CPCs was attenuated by PI3 kinase inhibitor LY294002 but not by mitogen-activated protein/ERK kinase inhibitor PD98059.
  • Analysis of cell cycle by flow cytometry revealed no significant difference in cell cycle between the transduced and control CPCs.
  • Thus, CST expression may increase CPCs migration via increasing CXCR4 expression and SDF-1/chemokine receptor signaling in a PI3/Akt-dependent manner.

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20813109.001).
  • [ISSN] 1090-2422
  • [Journal-full-title] Experimental cell research
  • [ISO-abbreviation] Exp. Cell Res.
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / R01HL69509
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies; 0 / Chemokine CXCL12; 0 / Clusterin; 0 / Enzyme Inhibitors; 0 / Receptors, CXCR4; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt
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7. Caravella A, Scura F, Barbieri G, Drioli E: Inhibition by CO and polarization in Pd-based membranes: a novel permeation reduction coefficient. J Phys Chem B; 2010 Sep 30;114(38):12264-76
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  • The membrane behavior is evaluated in terms of some "performance maps", where PRC and other two coefficients (concentration polarization coefficient (CPC) and inhibition coefficient (IC)) are reported as functions of several operating conditions (hydrogen molar fraction, CO partial pressure, and upstream total pressures).

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  • (PMID = 20815358.001).
  • [ISSN] 1520-5207
  • [Journal-full-title] The journal of physical chemistry. B
  • [ISO-abbreviation] J Phys Chem B
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Membranes, Artificial; 5TWQ1V240M / Palladium; 7U1EE4V452 / Carbon Monoxide; 7YNJ3PO35Z / Hydrogen
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8. Ensafi AA, Hemmateenejad B, Barzegar S: Non-extraction flow injection determination of cationic surfactants using eriochrome black-T. Spectrochim Acta A Mol Biomol Spectrosc; 2009 Sep 1;73(5):794-8
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  • A new, rapid, sensitive, non-extraction batch, and flow injection spectrophotometric method for the determination of cationic surfactants (CSs) such as cetyltrimethyl ammonium bromide (CTAB), tetra-n-butyl ammonium chloride (TBAC) and cetylpyridinium chloride (CPC) is proposed.

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  • (PMID = 19410502.001).
  • [ISSN] 1873-3557
  • [Journal-full-title] Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
  • [ISO-abbreviation] Spectrochim Acta A Mol Biomol Spectrosc
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Azo Compounds; 0 / Cetrimonium Compounds; 0 / Quaternary Ammonium Compounds; 0 / Surface-Active Agents; 0 / tetra-n-butylammonium chloride; 1787-61-7 / Eriochrome Black T; CUB7JI0JV3 / Cetylpyridinium; Z7FF1XKL7A / cetrimonium
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9. He XL, Wang YQ, Ling KQ: Synthesis of a novel bistriazene reagent 4,4'-bis[3-(4-phenylthiazol-2-yl)triazenyl]biphenyl and its highly sensitive color reaction with mercury(II). Talanta; 2007 Apr 30;72(2):747-54
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  • Using a blend of surfactants N-cetylpyridinium chloride (CPC) and polyethylene glycol n-octanoic phenyl ether (OP) as a micelle sensitizer, the red colored reagent assembles with Hg(2+) in pH 9.8 borate buffer according to a 1:1 stoichiometry, forming a blue oligomeric/polymeric chelating complex with a high apparent stability constant (1.1x10(8)M(-1)).

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  • (PMID = 19071681.001).
  • [ISSN] 1873-3573
  • [Journal-full-title] Talanta
  • [ISO-abbreviation] Talanta
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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10. Noller B, Poisson L, Maksimenka R, Gobert O, Fischer I, Mestdagh JM: Ultrafast dynamics of isolated phenylcarbenes followed by femtosecond time-resolved velocity map imaging. J Phys Chem A; 2009 Apr 2;113(13):3041-50
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  • The ultrafast dynamics of two carbene model systems, chlorophenylcarbene (CPC) and trifluoromethylphenylcarbene (TFPC), has been studied in a molecular beam.
  • CPC was excited at 265 nm into the 3 (1)A' state, corresponding to excitation from a pi-orbital of the aromatic ring into the lowest unoccupied molecular orbital, which contains the p-orbital at the carbene center.

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  • (PMID = 19245233.001).
  • [ISSN] 1520-5215
  • [Journal-full-title] The journal of physical chemistry. A
  • [ISO-abbreviation] J Phys Chem A
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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11. Kobayashi N, Ong K, Villarraga M, Schwardt J, Wenz R, Togawa D, Fujishiro T, Turner AS, Seim HB 3rd, Bauer TW: Histological and mechanical evaluation of self-setting calcium phosphate cements in a sheep vertebral bone void model. J Biomed Mater Res A; 2007 Jun 15;81(4):838-46
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  • We investigated the histological and compressive properties of three different calcium phosphate cements (CPCs) using a sheep vertebral bone void model.
  • One of the CPCs contained barium sulfate to enhance its radiopacity.
  • Bone voids were surgically created in the lumbar region of 23 ovine spines - L3, L4, and L5 (n = 69 total vertebral bodies) - and the voids were filled with one of the three CPCs.
  • All three CPCs were biocompatible and extremely osteoconductive.
  • Compressive testing did not reveal a significant difference in the ultimate strength, ultimate strain, and structural modulus, among the three CPCs and intact whole vertebrae.
  • Micro-CT analysis revealed good osseointegration between all three CPCs and adjacent bone.
  • The barium sulfate did not affect the CPCs biocompatibility or mechanical properties.
  • These results suggest that CPC might be a good alternative to polymethylmethacrylate for selected indications.

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  • [Copyright] (c) 2007 Wiley Periodicals, Inc.
  • (PMID = 17236211.001).
  • [ISSN] 1549-3296
  • [Journal-full-title] Journal of biomedical materials research. Part A
  • [ISO-abbreviation] J Biomed Mater Res A
  • [Language] eng
  • [Grant] United States / NIAMS NIH HHS / AR / AR 050953
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bone Cements; 0 / Calcium Phosphates; 97Z1WI3NDX / calcium phosphate
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12. Niu W, Zheng S, Wang D, Liu X, Li H, Han S, Chen J, Tang Z, Xu G: Selective synthesis of single-crystalline rhombic dodecahedral, octahedral, and cubic gold nanocrystals. J Am Chem Soc; 2009 Jan 21;131(2):697-703
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  • In the seed-mediated growth method, cetylpyridinium chloride (CPC) and CPC-capped single-crystalline gold nanocrystals 41.3 nm in size are used as the surfactant and seeds, respectively.
  • The CPC-capped gold seeds can avoid twinning during the growth process, which enables us to study the correlations between the growth conditions and the shapes of the gold nanocrystals.
  • CPC surfactants are found to alter the surface energies of gold facets in the order {100} > {110} > {111} under the growth conditions in this study, whereas the growth kinetics leads to the formation of thermodynamically less favored shapes that are not bounded by the most stable facets.
  • The competition between AuCl(4)(-) reduction and the CPC capping process on the {111} and {110} facets of gold nanocrystals plays an important role in the formation of the rhombic dodecahedral (RD) and octahedral gold nanocrystals.
  • Octahedral nanocrystals are formed when the capping of CPC on {111} facets dominates, while RD nanocrystals are formed when the reduction of AuCl(4)(-) on {111} facets dominates.
  • Cubic gold nanocrystals are formed by the introduction of bromide ions in the presence of CPC.

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  • (PMID = 19102696.001).
  • [ISSN] 1520-5126
  • [Journal-full-title] Journal of the American Chemical Society
  • [ISO-abbreviation] J. Am. Chem. Soc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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13. Kelly AE, Ghenoiu C, Xue JZ, Zierhut C, Kimura H, Funabiki H: Survivin reads phosphorylated histone H3 threonine 3 to activate the mitotic kinase Aurora B. Science; 2010 Oct 8;330(6001):235-9
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  • Here, we demonstrate that histone H3 phosphorylated at threonine 3 is directly recognized by an evolutionarily conserved binding pocket in the BIR domain of Survivin, which is a member of the chromosomal passenger complex (CPC).
  • This binding mediates recruitment of the CPC to chromosomes and the resulting activation of its kinase subunit Aurora B.
  • These findings establish a direct cellular role for mitotic histone H3T3 phosphorylation, which is read and translated by the CPC to ensure accurate cell division.

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  • (PMID = 20705815.001).
  • [ISSN] 1095-9203
  • [Journal-full-title] Science (New York, N.Y.)
  • [ISO-abbreviation] Science
  • [Language] ENG
  • [Databank-accession-numbers] GENBANK/ HM559585
  • [Grant] United States / NIGMS NIH HHS / GM / GM075249-05; United States / NIGMS NIH HHS / GM / R01 GM075249-05; United States / NIGMS NIH HHS / GM / GM075249-02; United States / NIGMS NIH HHS / GM / GM075249-05S1; United States / NIGMS NIH HHS / GM / GM075249-01; United States / NIGMS NIH HHS / GM / R01 GM075249-05S1; United States / NIGMS NIH HHS / GM / GM075249-03; United States / NIGMS NIH HHS / GM / GM075249; United States / NIGMS NIH HHS / GM / R01 GM075249-02; United States / NIGMS NIH HHS / GM / R01 GM075249-04; United States / NIGMS NIH HHS / GM / R01 GM075249-03; United States / NIGMS NIH HHS / GM / R01 GM075249; United States / NIGMS NIH HHS / GM / R01 GM075249-01; United States / NIGMS NIH HHS / GM / GM075249-04
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chromatin; 0 / Chromosomal Proteins, Non-Histone; 0 / Dasra A protein, Xenopus; 0 / Histones; 0 / INCENP protein, Xenopus; 0 / SIX protein, Xenopus; 0 / Xenopus Proteins; 0 / survivin protein, Xenopus laevis; 2ZD004190S / Threonine; EC 2.7.11.1 / Aurora Kinases; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; EC 2.7.11.1 / haspin protein, Xenopus laevis
  • [Other-IDs] NLM/ NIHMS256219; NLM/ PMC3177562
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14. Matsuura K, Honda A, Nagai T, Fukushima N, Iwanaga K, Tokunaga M, Shimizu T, Okano T, Kasanuki H, Hagiwara N, Komuro I: Transplantation of cardiac progenitor cells ameliorates cardiac dysfunction after myocardial infarction in mice. J Clin Invest; 2009 Aug;119(8):2204-17
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  • The present study demonstrates that transplantation of sheets of clonally expanded stem cell antigen 1-positive (Sca-1-positive) cells (CPCs) ameliorates cardiac dysfunction after myocardial infarction in mice.
  • CPC efficiently differentiated into cardiomyocytes and secreted various cytokines, including soluble VCAM-1 (sVCAM-1).
  • Secreted sVCAM-1 induced migration of endothelial cells and CPCs and prevented cardiomyocyte death from oxidative stress through activation of Akt, ERK, and p38 MAPK.
  • Treatment with antibodies specific for very late antigen-4 (VLA-4), a receptor of sVCAM-1, abolished the effects of CPC-derived conditioned medium on cardiomyocytes and CPCs in vitro and inhibited angiogenesis, CPC migration, and survival in vivo, which led to attenuation of improved cardiac function following transplantation of CPC sheets.
  • These results suggest that CPC transplantation improves cardiac function after myocardial infarction through cardiomyocyte differentiation and paracrine mechanisms mediated via the sVCAM-1/VLA-4 signaling pathway.


15. Yang K, Jing Q, Wu W, Zhu L, Xing B: Adsorption and conformation of a cationic surfactant on single-walled carbon nanotubes and their influence on naphthalene sorption. Environ Sci Technol; 2010 Jan 15;44(2):681-7
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  • The cationic surfactant, cetylpyridinium chloride (CPC), decreased naphthalene sorption on single-walled carbon nanotubes (SWCNT).
  • The decrease of naphthalene sorption could be largely attributed to the competition of adsorbed CPC cations (i.e., C(21)H(38)N(+)) with naphthalene by occupying the SWCNT surface as surfaces decreased from 737 to 88.9 m(2)/g after the coating of CPC.
  • However, the adsorbed CPC may form hemimicelles and result in a favorable media for naphthalene partition to counteract the decrease in naphthalene sorption.
  • Configuration changes of adsorbed CPC hemimicelles might occur because the naphthalene partition into the adsorbed CPC decreased with the increase of adsorbed CPC.
  • A partition-adsorption model was introduced to describe the partition fraction of naphthalene into adsorbed CPC hemimicelles as well as the adsorption fraction of naphthalene on unoccupied surfaces of SWCNT.

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  • (PMID = 20000820.001).
  • [ISSN] 0013-936X
  • [Journal-full-title] Environmental science & technology
  • [ISO-abbreviation] Environ. Sci. Technol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Nanotubes, Carbon; 0 / Naphthalenes; 0 / Surface-Active Agents; 2166IN72UN / naphthalene
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16. Oztürkmen Y, Caniklioğlu M, Karamehmetoğlu M, Sükür E: Calcium phosphate cement augmentation in the treatment of depressed tibial plateau fractures with open reduction and internal fixation. Acta Orthop Traumatol Turc; 2010;44(4):262-9
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  • OBJECTIVES: We aimed to evaluate the clinical and radiological outcomes of open reduction and internal fixation augmented with calcium phosphate cement (CPC) in the treatment of depressed tibial plateau fractures.
  • METHODS: Twenty-eight knees of 28 patients [19 males and 9 females; mean age, 41.2 years (range 22-72 years)] who had open reduction and internal fixation combined with CPC augmentation were included in this study.
  • Seventeen fractures were Schatzker type II, 5 were type III, 3 were type IV, 2 were type V, and 1 was type VI.
  • CPC was used to fill the subchondral bone defects in all knees.
  • Resorption of CPC granules was defined as the decrease in the size and density of grafting material on radiographs.
  • CONCLUSION: CPC is a safe biomaterial with many advantages in augmenting the open reduction and internal fixation of depressed tibial plateau fractures, including elimination of morbidity associated with bone graft harvesting, the unlimited supply of bone substitute, the optimum filling of irregular bone defects, and shortening of the postoperative full weight-bearing time.

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  • (PMID = 21252602.001).
  • [ISSN] 1017-995X
  • [Journal-full-title] Acta orthopaedica et traumatologica turcica
  • [ISO-abbreviation] Acta Orthop Traumatol Turc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Turkey
  • [Chemical-registry-number] 0 / Bone Cements; 0 / Bone Substitutes; 0 / Calcium Phosphates
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17. Ouzounian JG, Ludington C, Chan S: Isolated choroid plexus cyst or echogenic cardiac focus on prenatal ultrasound: is genetic amniocentesis indicated? Am J Obstet Gynecol; 2007 Jun;196(6):595.e1-3; discussion 595.e3
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  • [Title] Isolated choroid plexus cyst or echogenic cardiac focus on prenatal ultrasound: is genetic amniocentesis indicated?
  • OBJECTIVE: The purpose of this study was to determine whether or not genetic amniocentesis is warranted when isolated choroid plexus cysts (CPC) or echogenic cardiac foci (EF) are noted on prenatal ultrasound.
  • All obstetric patients with CPC or EF noted on second-trimester perinatology ultrasound from April, 1998 to November, 2004 were included.
  • RESULTS: During the study period, 515 patients with CPC or EF were evaluated.
  • Of these, 429 (83.3%) had isolated CPC or EF and 86 (16.7%) had additional risk factors.
  • Of these, none had isolated CPC or EF on prenatal ultrasound.
  • CONCLUSION: CPC or EF noted on prenatal ultrasound warrants referral for careful consultative ultrasound evaluation.
  • In the absence of other risk factors, however, genetic amniocentesis for isolated CPC or EF does not appear to be necessary.
  • [MeSH-major] Amniocentesis. Brain Diseases / ultrasonography. Choroid Plexus / ultrasonography. Cysts / ultrasonography. Heart Defects, Congenital / ultrasonography. Ultrasonography, Prenatal
  • [MeSH-minor] Adult. Chromosome Aberrations. Databases as Topic. Down Syndrome / diagnosis. Female. Humans. Karyotyping. Pregnancy. Pregnancy Trimester, Second. Prospective Studies. Retrospective Studies. Risk Factors


18. St John SJ, Hallagan LD: Psychophysical investigations of cetylpyridinium chloride in rats: its inherent taste and modifying effects on salt taste. Behav Neurosci; 2005 Feb;119(1):265-79
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  • Salts are transduced by at least 2 mechanisms: (a) antagonized by amiloride and (b) antagonized by cetylpyridinium chloride (CPC).
  • The authors report on 4 behavioral experiments in rats that characterize the orosensory properties of CPC itself as well as its effect in suppressing the intensity of NaCl and KCl taste.
  • Experiments 1 and 2 indicated that CPC has a quinine-like taste quality.
  • Experiments 3 and 4 demonstrated that the recognition of KCl, but not NaCl, is modestly reduced by mixture with CPC.
  • However, control experiments call into question the mechanism of the salt suppression of CPC, because both CPC-salt and quinine-salt mixtures had similar effects.

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  • [Copyright] Copyright 2005 APA.
  • (PMID = 15727531.001).
  • [ISSN] 0735-7044
  • [Journal-full-title] Behavioral neuroscience
  • [ISO-abbreviation] Behav. Neurosci.
  • [Language] eng
  • [Grant] United States / PHS HHS / / DX006886
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antimalarials; 0 / Detergents; 451W47IQ8X / Sodium Chloride; A7V27PHC7A / Quinine; CUB7JI0JV3 / Cetylpyridinium
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19. Hallstrom A, Rea TD, Sayre MR, Christenson J, Anton AR, Mosesso VN Jr, Van Ottingham L, Olsufka M, Pennington S, White LJ, Yahn S, Husar J, Morris MF, Cobb LA: Manual chest compression vs use of an automated chest compression device during resuscitation following out-of-hospital cardiac arrest: a randomized trial. JAMA; 2006 Jun 14;295(22):2620-8
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  • [Title] Manual chest compression vs use of an automated chest compression device during resuscitation following out-of-hospital cardiac arrest: a randomized trial.
  • Compared with manual chest compression, an automated load-distributing band (LDB) chest compression device produces greater blood flow to vital organs and may improve resuscitation outcomes.

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  • [CommentIn] JAMA. 2006 Jun 14;295(22):2661-4 [16772632.001]
  • (PMID = 16772625.001).
  • [ISSN] 1538-3598
  • [Journal-full-title] JAMA
  • [ISO-abbreviation] JAMA
  • [Language] ENG
  • [Databank-accession-numbers] ClinicalTrials.gov/ NCT00120965
  • [Publication-type] Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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20. Maxeiner H, Krehbiehl N, Müller A, Woitasky N, Akintürk H, Müller M, Weigand MA, Abdallah Y, Kasseckert S, Schreckenberg R, Schlüter KD, Wenzel S: New insights into paracrine mechanisms of human cardiac progenitor cells. Eur J Heart Fail; 2010 Jul;12(7):730-7
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  • AIMS: Cardiac progenitor cells (CPCs) have been shown to promote cardiac regeneration in vivo.
  • Understanding the function of CPCs is essential for further implementation of these cells in the treatment of cardiac diseases.
  • The present study tested the hypothesis that adult CPC exert paracrine effects that lead to an improvement in the functional characteristics of cardiomyocytes.
  • This study also investigated whether aging (we included patients aged between 4 months and 81 years) has any effect on the paracrine mechanisms of CPC.
  • METHODS AND RESULTS: The supernatant of CPC generated both from human and rat hearts-so called 'conditioned cardiosphere medium' improved the contractile behaviour of isolated adult cardiomyocytes in a concentration-dependent manner after incubation for 24 h and increased the SERCA/NCX ratio.
  • The observed positive effects on contractile behaviour were independent of the CPC donors' age.
  • Cytokines released by CPC into the media were detected by cytokine arrays.
  • CONCLUSION: The observed diversity of cytokines released by CPC needs to be further elucidated in detail.
  • Nevertheless, CPC are a promising therapeutic approach in the field of cardiac disease.

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  • [CommentIn] Eur J Heart Fail. 2010 Jul;12(7):642-4 [20576832.001]
  • (PMID = 20406797.001).
  • [ISSN] 1879-0844
  • [Journal-full-title] European journal of heart failure
  • [ISO-abbreviation] Eur. J. Heart Fail.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Culture Media, Conditioned; 0 / Cytokines
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21. Abbes K, Khabir A, Bahloul K, Boudawara MZ, Boudawara TS: [Choroid plexus carcinoma: a case report]. Neurochirurgie; 2009 Jun;55(3):333-6
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  • [Title] [Choroid plexus carcinoma: a case report].
  • [Transliterated title] Carcinome du plexus choroïde : à propos d'un cas.
  • OBJECTIVE: Choroid plexus carcinomas are rare and occur more frequently in children than in adults.
  • The differential diagnosis includes choroid plexus papilloma and papillary ependymoma.
  • The objective of this paper is to discuss the epidemiological characteristics, diagnosis, treatment, and prognosis of this rare childhood tumor.
  • The histopathological examination of the excised tumor identified a choroid plexus carcinoma.
  • CONCLUSION: Choroid plexus carcinomas are rare and treatment is currently controversial.
  • [MeSH-major] Carcinoma / surgery. Choroid Plexus Neoplasms / surgery

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  • (PMID = 18804822.001).
  • [ISSN] 0028-3770
  • [Journal-full-title] Neuro-Chirurgie
  • [ISO-abbreviation] Neurochirurgie
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen
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22. Albert-Kiszely A, Pjetursson BE, Salvi GE, Witt J, Hamilton A, Persson GR, Lang NP: Comparison of the effects of cetylpyridinium chloride with an essential oil mouth rinse on dental plaque and gingivitis - a six-month randomized controlled clinical trial. J Clin Periodontol; 2007 Aug;34(8):658-67
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  • OBJECTIVE: To compare the effects of an experimental mouth rinse containing 0.07% cetylpyridinium chloride (CPC) (Crest Pro-Health) with those provided by a commercially available mouth rinse containing essential oils (EOs) (Listerine) on dental plaque accumulation and prevention of gingivitis in an unsupervised 6-month randomized clinical trial.
  • MATERIAL AND METHODS: This double-blind, 6-month, parallel group, positively controlled study involved 151 subjects balanced and randomly assigned to either positive control (EO) or experimental (CPC) mouth rinse treatment groups.
  • RESULTS: Results show that after 3 and 6 months of rinsing, there were no significant differences (p=0.05) between the experimental (CPC) and the positive control mouth rinse treatment groups for overall gingivitis status, gingival bleeding, and plaque accumulation.
  • At 6 months, the covariant (baseline) adjusted mean GI and bleeding sites percentages for the CPC and the EO rinses were 0.52 and 0.53 and 8.7 and 9.3, respectively.
  • Statistically, a significant greater reduction in bleeding sites was observed for the CPC rinse versus the EO rinse.
  • CONCLUSION: The essential findings of this study indicated that there was no statistically significant difference in the anti-plaque and anti-gingivitis benefits between the experimental CPC mouth rinse and the positive control EO mouth rinse over a 6-month period.

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  • [CommentIn] J Evid Based Dent Pract. 2008 Jun;8(2):85-6 [18492580.001]
  • (PMID = 17635245.001).
  • [ISSN] 0303-6979
  • [Journal-full-title] Journal of clinical periodontology
  • [ISO-abbreviation] J. Clin. Periodontol.
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Anti-Infective Agents, Local; 0 / Mouthwashes; 0 / Oils, Volatile; CUB7JI0JV3 / Cetylpyridinium
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23. Assmus B, Honold J, Schächinger V, Britten MB, Fischer-Rasokat U, Lehmann R, Teupe C, Pistorius K, Martin H, Abolmaali ND, Tonn T, Dimmeler S, Zeiher AM: Transcoronary transplantation of progenitor cells after myocardial infarction. N Engl J Med; 2006 Sep 21;355(12):1222-32
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  • BACKGROUND: Pilot studies suggest that intracoronary transplantation of progenitor cells derived from bone marrow (BMC) or circulating blood (CPC) may improve left ventricular function after acute myocardial infarction.
  • METHODS: After an initial pilot trial involving 17 patients, we randomly assigned, in a controlled crossover study, 75 patients with stable ischemic heart disease who had had a myocardial infarction at least 3 months previously to receive either no cell infusion (23 patients) or infusion of CPC (24 patients) or BMC (28 patients) into the patent coronary artery supplying the most dyskinetic left ventricular area.
  • The patients in the control group were subsequently randomly assigned to receive CPC or BMC, and the patients who initially received BMC or CPC crossed over to receive CPC or BMC, respectively, at 3 months' follow-up.
  • RESULTS: The absolute change in left ventricular ejection fraction was significantly greater among patients receiving BMC (+2.9 percentage points) than among those receiving CPC (-0.4 percentage point, P=0.003) or no infusion (-1.2 percentage points, P<0.001).
  • The crossover phase of the study revealed that intracoronary infusion of BMC was associated with a significant increase in global and regional left ventricular function, regardless of whether patients crossed over from control to BMC or from CPC to BMC.


24. Fan X, Zhu TL, Wang MY, Li XM: Removal of low-concentration BTX in air using a combined plasma catalysis system. Chemosphere; 2009 Jun;75(10):1301-6
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  • The behavior of non-thermal plasma (NTP) and combined plasma catalysis (CPC) was investigated for removal of low-concentration benzene, toluene and p-xylene (BTX mixture) in air using a link tooth wheel-cylinder plasma reactor.
  • Combining NTP with MnO(x)/Al(2)O(3) catalyst after the discharge zone (CPC) significantly promoted BTX conversion and improved the energy efficiency.
  • For an SIE of 10 JL(-1), the O(3) outlet concentration decreased from 46.7 for NTP alone to 1.9 ppm for CPC, while the NO(2) emission correspondingly decreased from 1380 to 40 ppb.

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  • (PMID = 19375149.001).
  • [ISSN] 1879-1298
  • [Journal-full-title] Chemosphere
  • [ISO-abbreviation] Chemosphere
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Manganese Compounds; 0 / Oxides; 0 / Xylenes; 1317-35-7 / manganese oxide; 31C4KY9ESH / Nitric Oxide; 3FPU23BG52 / Toluene; 66H7ZZK23N / Ozone; 6WAC1O477V / 4-xylene; J64922108F / Benzene; LMI26O6933 / Aluminum Oxide
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25. Quirynen M, Zhao H, Soers C, Dekeyser C, Pauwels M, Coucke W, Steenberghe Dv: The impact of periodontal therapy and the adjunctive effect of antiseptics on breath odor-related outcome variables: a double-blind randomized study. J Periodontol; 2005 May;76(5):705-12
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  • Besides a one-stage, full-mouth disinfection and oral hygiene improvement (including daily tongue scraping), patients were instructed to rinse daily for 6 months with one of the following products (randomly allocated): chlorhexidine (CHX) 0.2% + alcohol, CHX 0.05% + cetyl pyridinium chloride (CPC) 0.05% without alcohol (a new formulation), or a placebo solution.
  • RESULTS: Even though the initial VSC values were not high (+/-90 ppb with only 18 patients revealing more than 100 ppb), significant (P <0.05) reductions could be achieved in the CHX and CHX + CPC group, and to a lower extent in the placebo group (P = 0.10).
  • Tongue scraping resulted in a significant reduction (P < or =0.05) of the tongue coating up to month 6 in the placebo and CHX + CPC group, but not in the CHX group (confusion due to staining).
  • The CHX and CHX + CPC group showed, in comparison to baseline, significant (P <0.001) reductions in the number of anaerobic species in the supragingival plaque, in the saliva, and on the anterior part of the tongue.

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  • (PMID = 15898930.001).
  • [ISSN] 0022-3492
  • [Journal-full-title] Journal of periodontology
  • [ISO-abbreviation] J. Periodontol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Infective Agents, Local; R4KO0DY52L / Chlorhexidine
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26. Koshino-Kimura Y, Wada T, Tachibana T, Tsugeki R, Ishiguro S, Okada K: Regulation of CAPRICE transcription by MYB proteins for root epidermis differentiation in Arabidopsis. Plant Cell Physiol; 2005 Jun;46(6):817-26
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  • One of these, CAPRICE (CPC), encoding an R3-type MYB protein, is a positive regulator of hair cell differentiation and is preferentially transcribed in hairless cells.
  • We analyzed the regulatory mechanism of CPC transcription.
  • Deletion analyses of the CPC promoter revealed that hairless cell-specific transcription of the CPC gene required a 69 bp sequence, and a tandem repeat of this region was sufficient for its expression in epidermis.
  • This region includes two MYB-binding sites, and the epidermis-specific transcription of CPC was abolished when base substitutions were introduced in these sites.
  • We showed by gel mobility shift experiments and by yeast one-hybrid assay that WEREWOLF (WER), which is an R2R3-type MYB protein, directly binds to this region.
  • We showed that WER also binds to the GL2 promoter region, indicating that WER directly regulates CPC and GL2 transcription by binding to their promoter regions.

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  • (PMID = 15795220.001).
  • [ISSN] 0032-0781
  • [Journal-full-title] Plant & cell physiology
  • [ISO-abbreviation] Plant Cell Physiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / ATR1 protein, Arabidopsis; 0 / Arabidopsis Proteins; 0 / CPC protein, Arabidopsis; 0 / DNA, Plant; 0 / DNA-Binding Proteins; 0 / GL2 protein, Arabidopsis; 0 / Homeodomain Proteins; 0 / Myb protein, Arabidopsis; 0 / Plant Proteins; 0 / Proto-Oncogene Proteins c-myb; 0 / Transcription Factors; 0 / WER protein, Arabidopsis
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27. Hassan S: About Clinicopathological Conference and Its' Practice in the School of Medical Sciences, USM. Malays J Med Sci; 2006 Jul;13(2):7-10
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  • The clinicopathological conference, popularly known as CPC primarily relies on case method of teaching medicine.
  • It is a teaching tool that illustrates the logical, measured consideration of a differential diagnosis used to evaluate patients.
  • The process involves case presentation, diagnostic data, discussion of differential diagnosis, logically narrowing the list to few selected probable diagnoses and eventually reaching a final diagnosis and its brief discussion.

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  • (PMID = 22589598.001).
  • [ISSN] 1394-195X
  • [Journal-full-title] The Malaysian journal of medical sciences : MJMS
  • [ISO-abbreviation] Malays J Med Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Malaysia
  • [Other-IDs] NLM/ PMC3349478
  • [Keywords] NOTNLM ; Clinicopathological conference / University Sains Malaysia / medical eduction / medical school
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28. Zhu YY, Zhu-Ge ZB, Wang S, Yang LX, Chen Z: [Injection of saline into unilateral central piriform cortex inhibits amygdaloid-kindled seizures in rats]. Zhejiang Da Xue Xue Bao Yi Xue Ban; 2007 Mar;36(2):141-5
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  • OBJECTIVE: To investigate the effect of microinjection of saline into unilateral central piriform cortex (cPC) on the generalized seizures in amygdaloid-kindled rats.
  • METHODS: Different volumes of saline were injected into the right or left cPC of amygdaloid-kindled rats, and its effect on generalized seizures was observed.
  • CONCLUSION: Unilateral saline injection into cPC has a significant anticonvulsant effect, which might be used for treatment of human temporal lobe epilepsy in the future.

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  • (PMID = 17443901.001).
  • [ISSN] 1008-9292
  • [Journal-full-title] Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences
  • [ISO-abbreviation] Zhejiang Da Xue Xue Bao Yi Xue Ban
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Anticonvulsants; 451W47IQ8X / Sodium Chloride
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29. Singh A, Vermani S, Shruti S: Choroid plexus carcinoma: report of two cases. Indian J Pathol Microbiol; 2009 Jul-Sep;52(3):405-7
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  • [Title] Choroid plexus carcinoma: report of two cases.
  • Choroid plexus carcinomas (CPCs) are rare malignant counterparts of choroid plexus papilloma which occur in infants and children with a predilection for the posterior fossa and have a poor prognosis.
  • We report two cases of CPC diagnosed in a 5-year-old boy and a 12-year-old boy and discuss the clinicopathologic features.
  • [MeSH-major] Carcinoma / diagnosis. Carcinoma / pathology. Choroid Plexus Neoplasms / diagnosis. Choroid Plexus Neoplasms / pathology
  • [MeSH-minor] Animals. Child. Child, Preschool. Choroid Plexus / pathology. Histocytochemistry. Humans. Male

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  • (PMID = 19679976.001).
  • [ISSN] 0974-5130
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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30. Nerapusri V, Keddie JL, Vincent B, Bushnak IA: Absorption of cetylpyridinium chloride into poly(N-isopropylacrylamide)-based microgel particles, in dispersion and as surface-deposited monolayers. Langmuir; 2007 Sep 11;23(19):9572-7
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  • The addition of cetylpyridinium chloride (CPC) to aqueous dispersions of poly(N-isopropylacrylamide) [poly(NIPAM)] and poly(N-isopropylacrylamide-co-acrylic acid) [poly(NIPAM-co-AAc)] microgel particles leads to absorption of the CPC into the particles and to corresponding changes in their hydrodynamic diameter.
  • The dependence of both hydrodynamic diameter and electrophoretic mobility of the microgel particles on the added CPC concentration show a strong correlation with CPC uptake, as obtained from direct CPC absorption measurements.
  • Various mechanisms for CPC absorption into the microgel particles are postulated, including electrostatic, polar, and hydrophobic interactions.
  • A comparison has also been made between the effect of added CPC on the hydrodynamic diameter of free microgel particles in dispersion, determined by dynamic light scattering, and the thickness of adsorbed monolayers of the same microgel particles deposited on cationically modified, oxidized silicon surfaces, as determined from ellipsometry measurements.

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  • (PMID = 17685638.001).
  • [ISSN] 0743-7463
  • [Journal-full-title] Langmuir : the ACS journal of surfaces and colloids
  • [ISO-abbreviation] Langmuir
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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31. Shinomiya K, Kobayashi H, Motoyoshi N, Inokuchi N, Nakagomi K, Ito Y: Countercurrent chromatographic separation and purification of various ribonucleases using a small-scale cross-axis coil planet centrifuge with aqueous-aqueous polymer phase systems. J Chromatogr B Analyt Technol Biomed Life Sci; 2009 Apr 01;877(10):955-60
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  • Countercurrent chromatographic (CCC) separation and purification of various ribonucleases (RNases) was performed using the small-scale cross-axis coil planet centrifuge (X-axis CPC) with aqueous-aqueous polymer phase systems.
  • The overall results demonstrate that the small-scale X-axis CPC is useful for a simple and rapid purification of various RNases in a preparative-scale.

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  • (PMID = 19272844.001).
  • [ISSN] 1873-376X
  • [Journal-full-title] Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
  • [ISO-abbreviation] J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z99 HL999999
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Phosphates; 0 / Potassium Compounds; 30IQX730WE / Polyethylene Glycols; B7862WZ632 / potassium phosphate; EC 3.1.- / Ribonucleases
  • [Other-IDs] NLM/ NIHMS142244; NLM/ PMC2745059
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32. Burguera EF, Xu HH, Sun L: Injectable calcium phosphate cement: effects of powder-to-liquid ratio and needle size. J Biomed Mater Res B Appl Biomater; 2008 Feb;84(2):493-502
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  • Calcium phosphate cement (CPC) sets in situ and forms apatite with excellent osteoconductivity and bone-replacement capability.
  • The objectives of this study were to formulate an injectable tetracalcium phosphate-dicalcium phosphate cement (CPC(D)), and investigate the powder/liquid ratio and needle-size effects.
  • The strength of the injectable CPC(D) matched/exceeded the reported strengths of sintered porous hydroxyapatite implants that required machining.
  • The novel injectable CPC(D) with a relatively high strength may be useful in filling defects with limited accessibility such as periodontal repair and tooth root-canal fillings, and in minimally-invasive techniques such as percutaneous vertebroplasty to fill the lesions and to strengthen the osteoporotic bone.

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  • [Copyright] (c) 2007 Wiley Periodicals, Inc.
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  • (PMID = 17635038.001).
  • [ISSN] 1552-4981
  • [Journal-full-title] Journal of biomedical materials research. Part B, Applied biomaterials
  • [ISO-abbreviation] J. Biomed. Mater. Res. Part B Appl. Biomater.
  • [Language] ENG
  • [Grant] United States / NIDCR NIH HHS / DE / R01 DE014190-01A2; United States / NIDCR NIH HHS / DE / DE014190-05; United States / NIDCR NIH HHS / DE / R01 DE014190-06; United States / NIDCR NIH HHS / DE / DE014190-03; United States / NIDCR NIH HHS / DE / DE014190-02; United States / NIDCR NIH HHS / DE / R01 DE014190-03; United States / NIDCR NIH HHS / DE / R01 DE014190-05; United States / NIDCR NIH HHS / DE / R01 DE014190; United States / NIDCR NIH HHS / DE / R01 DE14190; United States / NIDCR NIH HHS / DE / DE014190-01A2; United States / NIDCR NIH HHS / DE / R01 DE014190-02; United States / NIDCR NIH HHS / DE / DE014190-04; United States / NIDCR NIH HHS / DE / R01 DE014190-04; United States / NIDCR NIH HHS / DE / DE014190-06
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bone Cements; 0 / Calcium Phosphates; 0 / Powders; 0 / tetracalcium phosphate; 91D9GV0Z28 / Durapatite; L11K75P92J / calcium phosphate, dibasic, anhydrous
  • [Other-IDs] NLM/ NIHMS89712; NLM/ PMC2652762
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33. Tadeu AM, Ribeiro S, Johnston J, Goldberg I, Gerloff D, Earnshaw WC: CENP-V is required for centromere organization, chromosome alignment and cytokinesis. EMBO J; 2008 Oct 08;27(19):2510-22
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  • CENP-V depletion in HeLa cells leads to abnormal expansion of the primary constriction of mitotic chromosomes, mislocalization and destabilization of the chromosomal passenger complex (CPC) and alterations in the distribution of H3K9me3 in interphase nucleoplasm.
  • CENP-V provides a novel link between centromeric chromatin, the primary constriction and the CPC.


34. Breynaert E, Maes A: Column precipitation chromatography: an approach to quantitative analysis of eigencolloids. Anal Chem; 2005 Aug 1;77(15):5048-54
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  • A new column precipitation chromatography (CPC) technique, capable of quantitatively measuring technetium eigencolloids in aqueous solutions, is presented.
  • The CPC technique is based on the destabilization and precipitation of eigencolloids by polycations in a confined matrix.
  • Tc(IV) colloids can be quantitatively determined from their precipitation onto the CPC column (separation step) and their subsequent elution upon oxidation to pertechnetate by peroxide (elution step).

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  • (PMID = 16053321.001).
  • [ISSN] 0003-2700
  • [Journal-full-title] Analytical chemistry
  • [ISO-abbreviation] Anal. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Colloids; N762921K75 / Nitrogen
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35. Namba N, Yoshida Y, Nagaoka N, Takashima S, Matsuura-Yoshimoto K, Maeda H, Van Meerbeek B, Suzuki K, Takashiba S: Antibacterial effect of bactericide immobilized in resin matrix. Dent Mater; 2009 Apr;25(4):424-30
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  • METHODS: Experimental resins containing 0, 1 and 3% cetylpyridinium chloride (CPC) were polymerized, and the bacteriostatic and bactericidal effects against Streptococcus mutans were determined.
  • The amount of CPC released from the 0%-, 1%- and 3%-CPC resin sample into water was spectrometrically quantified using a UV-vis recording spectrophotometer.
  • RESULTS: UV spectrometry revealed that less than 0.11 ppm of CPC was released from the resin into water for all specimens, which is lower than the minimal concentration generally needed to inhibit biofilm formation.
  • Growth of S. mutans was significantly inhibited on the surface of the 3%-CPC-containing resin coating, although no inhibitory effect was observed on bacteria that were not in contact with its surface.
  • When immersed in water, the antibacterial capability of 3%-CPC resin lasted for 7 days, as compared to resin that did not contain CPC.

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  • (PMID = 19019421.001).
  • [ISSN] 1879-0097
  • [Journal-full-title] Dental materials : official publication of the Academy of Dental Materials
  • [ISO-abbreviation] Dent Mater
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Infective Agents, Local; 0 / DNA, Bacterial; 0 / Resin Cements; 91D9GV0Z28 / Durapatite; CUB7JI0JV3 / Cetylpyridinium
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36. Dos Reis AP, Tarley CR, Mello LD, Kubota LT: Simple and sensitive electroanalytical method for the determination of ascorbic acid in urine samples using measurements in an aqueous cationic micellar medium. Anal Sci; 2008 Dec;24(12):1569-74
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  • An electroanalytical study for the amperometric determination of ascorbic acid (AA) in a human urine sample at a bare glassy carbon electrode using the CPC (cetylpyridinium chloride) surfactant is described.
  • Under the optimized conditions of E(pa), I(pa), CPC concentration and pH, the oxidation peak potential of the AA shifts towards a less positive potential, and the peak current increase in a significant way in the presence of the surfactant.

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  • (PMID = 19075466.001).
  • [ISSN] 1348-2246
  • [Journal-full-title] Analytical sciences : the international journal of the Japan Society for Analytical Chemistry
  • [ISO-abbreviation] Anal Sci
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Micelles; 0 / Surface-Active Agents; 059QF0KO0R / Water; 7440-44-0 / Carbon; CUB7JI0JV3 / Cetylpyridinium; PQ6CK8PD0R / Ascorbic Acid
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37. Larkin GL, Copes WS, Nathanson BH, Kaye W: Pre-resuscitation factors associated with mortality in 49,130 cases of in-hospital cardiac arrest: a report from the National Registry for Cardiopulmonary Resuscitation. Resuscitation; 2010 Mar;81(3):302-11
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  • [Title] Pre-resuscitation factors associated with mortality in 49,130 cases of in-hospital cardiac arrest: a report from the National Registry for Cardiopulmonary Resuscitation.
  • AIM: To evaluate key pre-arrest factors and their collective ability to predict post-cardiopulmonary arrest mortality.
  • CPR is often initiated indiscriminately after in-hospital cardiopulmonary arrest.
  • Improved understanding of pre-arrest factors associated with mortality may inform advance care planning.
  • METHODS: A cohort of 49,130 adults who experienced pulseless cardiopulmonary arrest from January 2000 to September 2004 was obtained from 366 US hospitals participating in the National Registry for Cardiopulmonary Resuscitation (NRCPR).
  • Logistic regression with bootstrapping was used to model in-hospital mortality, which included those discharged in unfavorable and severely worsened neurologic state (Cerebral Performance Category >/=3).
  • RESULTS: Overall in-hospital mortality was 84.1%.
  • Advanced age, black race, non-cardiac, non-surgical illness category, pre-existing malignancy, acute stroke, trauma, septicemia, hepatic insufficiency, general floor or Emergency Department location, and pre-arrest use of vasopressors or assisted/mechanical ventilation were independently predictive of in-hospital mortality.
  • Retained peri-arrest factors including cardiac monitoring, and shockable initial pulseless rhythms, were strongly associated with survival.
  • The validation model's AUROC curve (0.77) revealed fair performance.
  • CONCLUSIONS: Predictive pre-resuscitation factors may supplement patient-specific information available at bedside to assist in revising resuscitation plans during the patient's hospitalization.
  • [MeSH-major] Cardiopulmonary Resuscitation. Heart Arrest / mortality. Heart Arrest / therapy. Hospital Mortality. Inpatients
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Cohort Studies. Female. Humans. Logistic Models. Male. Middle Aged. Multivariate Analysis. Patient Care Planning. Predictive Value of Tests. Registries. Risk Factors. Young Adult

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  • [Copyright] Copyright 2009. Published by Elsevier Ireland Ltd.
  • (PMID = 20047786.001).
  • [ISSN] 1873-1570
  • [Journal-full-title] Resuscitation
  • [ISO-abbreviation] Resuscitation
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
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38. Sandri M, Adams V, Gielen S, Linke A, Lenk K, Kränkel N, Lenz D, Erbs S, Scheinert D, Mohr FW, Schuler G, Hambrecht R: Effects of exercise and ischemia on mobilization and functional activation of blood-derived progenitor cells in patients with ischemic syndromes: results of 3 randomized studies. Circulation; 2005 Jun 28;111(25):3391-9
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  • BACKGROUND: Exercise training (ET) has been shown to improve regional perfusion in ischemic syndromes.
  • This might be partially related to a regeneration of diseased endothelium by circulating progenitor cells (CPCs) or CPC-derived vasculogenesis.
  • The aim of the present study was to determine whether ischemic stimuli during ET are required to promote CPC mobilization in patients with cardiovascular diseases.
  • At baseline and after 4 weeks, the number of KDR+/CD34+ CPCs was determined by fluorescence-activated cell sorting analysis.
  • A Matrigel assay was used to quantify CPC integration into vascular structures.
  • In group A only, ischemic ET increased VEGF levels by 310% (P<0.05 versus control) associated with an increase in CPCs by 440% (P<0.05 versus control), increased CXCR4 expression, and enhanced integration of CPCs into endothelial networks.
  • In contrast, subischemic ET in groups B and C increased CXCR4 expression and CPC integration.
  • CONCLUSIONS: In training programs, symptomatic tissue ischemia seems to be a prerequisite for CPC mobilization.
  • However, ischemic and subischemic ET programs affect CXCR4 expression of CPCs, which might lead to an improved CPC integration into endothelial networks.

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  • (PMID = 15956121.001).
  • [ISSN] 1524-4539
  • [Journal-full-title] Circulation
  • [ISO-abbreviation] Circulation
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Growth Substances; 0 / RNA, Messenger; 0 / Receptors, CXCR4; 0 / Vascular Endothelial Growth Factor A
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39. Ho CK, Peng CY, Yang CY: Traffic air pollution and risk of death from bladder cancer in Taiwan using petrol station density as a pollutant indicator. J Toxicol Environ Health A; 2010;73(1):23-32
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  • [Title] Traffic air pollution and risk of death from bladder cancer in Taiwan using petrol station density as a pollutant indicator.
  • To investigate the relationship between air pollution and risk of death from bladder cancer, a matched cancer case-control study was conducted using deaths that occurred in Taiwan from 1997 through 2006.
  • Data for all eligible bladder cancer deaths were obtained from the Bureau of Vital Statistics of the Taiwan Provincial Department of Health.
  • The control group consisted of individuals who died from causes other than cancer or diseases associated with genitourinary problems.
  • Data for the number of petrol stations in study municipalities were collected from the two major petroleum supply companies, Chinese Petroleum Corporation (CPC) and Formosa Petrochemical Corporation (FPCC).
  • The present study showed that individuals who resided in municipalities with high PSD levels were at an increased risk of death from bladder cancer compared to subjects living in municipalities with a low PSD level; however, the differences are not statistically significant.
  • The findings of this study warrant further investigation of the role of vehicular air pollutant emissions in the etiology of bladder cancer development.

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  • (PMID = 19953417.001).
  • [ISSN] 1528-7394
  • [Journal-full-title] Journal of toxicology and environmental health. Part A
  • [ISO-abbreviation] J. Toxicol. Environ. Health Part A
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Vehicle Emissions
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40. Beyer M, Ferse I, Humpf HU: Large-scale production of selected type A trichothecenes: the use of HT-2 toxin and T-2 triol as precursors for the synthesis of d 3-T-2 and d 3-HT-2 toxin. Mycotoxin Res; 2009 Mar;25(1):41-52
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  • [Title] Large-scale production of selected type A trichothecenes: the use of HT-2 toxin and T-2 triol as precursors for the synthesis of d 3-T-2 and d 3-HT-2 toxin.
  • The type A trichothecenes T-2 and HT-2 toxins are toxic secondary metabolites produced by fungi of the Fusarium genus.

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  • (PMID = 23604935.001).
  • [ISSN] 0178-7888
  • [Journal-full-title] Mycotoxin research
  • [ISO-abbreviation] Mycotoxin Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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41. Kobayashi H, Fujishiro T, Belkoff SM, Kobayashi N, Turner AS, Seim HB 3rd, Zitelli J, Hawkins M, Bauer TW: Long-term evaluation of a calcium phosphate bone cement with carboxymethyl cellulose in a vertebral defect model. J Biomed Mater Res A; 2009 Mar 15;88(4):880-8
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  • We investigated histological and compressive properties of a calcium phosphate bone cement (BoneSource (CPC); Stryker Orthopaedics, Mahwah, New Jersey) plus carboxymethyl cellulose (CMC) using a sheep vertebral bone void model.

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  • (PMID = 18381636.001).
  • [ISSN] 1552-4965
  • [Journal-full-title] Journal of biomedical materials research. Part A
  • [ISO-abbreviation] J Biomed Mater Res A
  • [Language] eng
  • [Grant] United States / NIAMS NIH HHS / AR / AR050953
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biocompatible Materials; 0 / Bone Cements; 9004-32-4 / Carboxymethylcellulose Sodium
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42. Dennehy CE, Tsourounis C, Horn AJ: Dietary supplement-related adverse events reported to the California Poison Control System. Am J Health Syst Pharm; 2005 Jul 15;62(14):1476-82
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  • PURPOSE: Dietary supplement (DS)-related adverse events (AEs) reported to the California Poison Control System (CPCS) were studied.
  • METHODS: The CPCS database was used to search for all telephone calls from consumers concerning DS-related AEs received during the six-month period between April and September 2002.
  • The calls were characterized according to the substance involved, the caller's age (adult or pediatric), and the type of ingestion (accidental or intentional).
  • CONCLUSION: A majority of DS-related AEs reported by consumers to CPCS involved ephedra-containing products.
  • [MeSH-major] Adverse Drug Reaction Reporting Systems. Dietary Supplements / adverse effects. Poison Control Centers

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  • (PMID = 15998927.001).
  • [ISSN] 1079-2082
  • [Journal-full-title] American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
  • [ISO-abbreviation] Am J Health Syst Pharm
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Drugs, Chinese Herbal
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43. Xu HH, Carey LE, Simon CG Jr: Premixed macroporous calcium phosphate cement scaffold. J Mater Sci Mater Med; 2007 Jul;18(7):1345-53
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  • Calcium phosphate cement (CPC) sets in situ to form resorbable hydroxyapatite and is promising for orthopaedic applications.
  • The objective of this study was to develop a premixed CPC scaffold with macropores suitable for tissue ingrowth.
  • To avoid the on-site powder-liquid mixing, the CPC paste was mixed in advance and did not set in storage; it set only after placement in a physiological solution.
  • Using 30% and 40% mass fractions of mannitol porogen, the premixed CPC scaffold with fibers had flexural strength (mean +/- sd; n = 5) of (3.9 +/- 1.4) MPa and (1.8 +/- 0.8) MPa, respectively.
  • Cell viability values for the premixed CPC scaffold was not significantly different from that of a conventional non-premixed CPC known to be biocompatible (P > 0.1).
  • In conclusion, using fast-dissolving porogen and slow-dissolving fibers, a premixed macroporous CPC scaffold was developed with strength approaching the reported strengths of sintered porous hydroxyapatite implants and cancellous bone, and non-cytotoxicity similar to a biocompatible non-premixed CPC.

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  • (PMID = 17277972.001).
  • [ISSN] 0957-4530
  • [Journal-full-title] Journal of materials science. Materials in medicine
  • [ISO-abbreviation] J Mater Sci Mater Med
  • [Language] ENG
  • [Grant] United States / NIDCR NIH HHS / DE / R01 DE014190; United States / NIDCR NIH HHS / DE / DE012476-05; United States / NIDCR NIH HHS / DE / R29 DE012476-05; United States / NIDCR NIH HHS / DE / DE14190; United States / NIDCR NIH HHS / DE / Y1-DE-1021; United States / NIDCR NIH HHS / DE / R29 DE012476; United States / NIDCR NIH HHS / DE / DE014190-04; United States / NIDCR NIH HHS / DE / R01 DE014190-04
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bone Cements; 0 / Calcium Phosphates; 97Z1WI3NDX / calcium phosphate
  • [Other-IDs] NLM/ NIHMS89762; NLM/ PMC2645046
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44. Haddad AJ, Peel SA, Clokie CM, Sándor GK: Closure of rabbit calvarial critical-sized defects using protective composite allogeneic and alloplastic bone substitutes. J Craniofac Surg; 2006 Sep;17(5):926-34
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  • The strategies employed included demineralized bone matrix (DBM), a putty used in combination with a rigid resorbable plating system as a protective covering and calcium phosphate cement (CPC) combined with native partially purified bone morphogenetic protein (BMP).
  • Group 3 had a CPC, Mimix (Lorenz Surgical, Jacksonville, Florida), placed into one of the defects while the defect on the other side was filled with the same CPC in combination with BMP in a concentration of 25 mg/mL.

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  • (PMID = 17003622.001).
  • [ISSN] 1049-2275
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bone Morphogenetic Proteins; 0 / Bone Substitutes; 0 / Calcium Phosphates; 0 / Polymers; 0 / polylactic acid-polyglycolic acid copolymer; 26009-03-0 / Polyglycolic Acid; 33X04XA5AT / Lactic Acid; 97Z1WI3NDX / calcium phosphate
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45. McMullen NM, Zhang F, Hotchkiss A, Bretzner F, Wilson JM, Ma H, Wafa K, Brownstone RM, Pasumarthi KB: Functional characterization of cardiac progenitor cells and their derivatives in the embryonic heart post-chamber formation. Dev Dyn; 2009 Nov;238(11):2787-99
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  • There is scant information on the fate of cardiac progenitor cells (CPC) in the embryonic heart after chamber specification.
  • Here we simultaneously tracked three lineage-specific markers (Nkx2.5, MLC2v, and ANF) and confirmed that CPCs with an Nkx2.5+MLC2v-ANF- phenotype are present in the embryonic (E) day 11.5 mouse ventricular myocardium.
  • We demonstrated that these CPCs could give rise to working cardiomyocytes and conduction system cells.
  • Using a two-photon imaging analysis, we found that the majority of CPCs are not capable of developing Ca2+ transients in response to beta-adrenergic receptor stimulation.

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  • [Copyright] Copyright 2009 Wiley-Liss, Inc.
  • (PMID = 19842178.001).
  • [ISSN] 1097-0177
  • [Journal-full-title] Developmental dynamics : an official publication of the American Association of Anatomists
  • [ISO-abbreviation] Dev. Dyn.
  • [Language] eng
  • [Grant] Canada / Canadian Institutes of Health Research / / MOP-62811
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Calcium Channels; 0 / Homeodomain Proteins; 0 / Mylpf protein, mouse; 0 / Myosin Light Chains; 0 / Nkx2-5 protein, mouse; 0 / Receptors, Adrenergic, beta; 0 / Receptors, Muscarinic; 0 / Transcription Factors; 85637-73-6 / Atrial Natriuretic Factor; EC 1.14.13.39 / Nitric Oxide Synthase; SY7Q814VUP / Calcium
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46. Wester T, Läckgren G, Christofferson R, Rintala RJ: The congenital pouch colon can be used for vaginal reconstruction by longitudinal splitting. J Pediatr Surg; 2006 Feb;41(2):e25-8
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  • Congenital pouch colon (CPC) is a rare malformation in which the distal part of a shortened colon forms a dilated pouch.
  • We report 2 patients with CPC, one with a cloaca and one with vestibular fistula and vaginal atresia.
  • It is the first description of CPC, vestibular fistula, and vaginal atresia.

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  • (PMID = 16481234.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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47. Fei Z, Hu Y, Wu D, Wu H, Lu R, Bai J, Song H: Preparation and property of a novel bone graft composite consisting of rhBMP-2 loaded PLGA microspheres and calcium phosphate cement. J Mater Sci Mater Med; 2008 Mar;19(3):1109-16
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  • Calcium phosphate cement (CPC) is a highly promising bone substitute and an excellent carrier for delivering growth factors.
  • RhBMP-2 loaded PLGA microspheres were incorporated into rhBMP-2/CPC for macropores for bone ingrowth.
  • X-ray diffraction revealed that the crystallinity pattern of HA formed by CPC had no significant change.
  • When the PLGA microspheres dissolved after having been emerged in PBS for 56 days, macropores were created within the CPC.
  • The rhBMP-2/PLGA/CPC composite, showing a 4.9% initial release of rhBMP-2 in 24 h, followed by a prolonged release for 28 days, should have a greater amount of rhBMP-2 released compared to the CPC delivery system.
  • This novel BMP/PLGA/CPC composite could be a promising synthetic bone graft in craniofacial and orthopedic repairs.

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  • (PMID = 17701313.001).
  • [ISSN] 0957-4530
  • [Journal-full-title] Journal of materials science. Materials in medicine
  • [ISO-abbreviation] J Mater Sci Mater Med
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bone Morphogenetic Protein 2; 0 / Bone Morphogenetic Proteins; 0 / Bone Substitutes; 0 / Calcium Phosphates; 0 / Recombinant Proteins; 0 / Resin Cements; 0 / Transforming Growth Factor beta; 0 / polylactic acid-polyglycolic acid copolymer; 26009-03-0 / Polyglycolic Acid; 33X04XA5AT / Lactic Acid; 97Z1WI3NDX / calcium phosphate
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48. Grandjean V, Yaman R, Cuzin F, Rassoulzadegan M: Inheritance of an epigenetic mark: the CpG DNA methyltransferase 1 is required for de novo establishment of a complex pattern of non-CpG methylation. PLoS One; 2007;2(11):e1136
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  • [Title] Inheritance of an epigenetic mark: the CpG DNA methyltransferase 1 is required for de novo establishment of a complex pattern of non-CpG methylation.
  • While a majority of the methylated residues are in the symmetrical (meC)pG:Gp(meC) configuration, a smaller, but significant fraction is found in the CpA, CpT and CpC asymmetric (non-CpG) dinucleotides.


49. Matson U: Indoor and outdoor concentrations of ultrafine particles in some Scandinavian rural and urban areas. Sci Total Environ; 2005 May 1;343(1-3):169-76
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  • The instruments used are handheld real-time condensation particle counters, models CPC 3007 and P-Trak 8525, both manufactured by TSI.

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  • (PMID = 15862843.001).
  • [ISSN] 0048-9697
  • [Journal-full-title] The Science of the total environment
  • [ISO-abbreviation] Sci. Total Environ.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Air Pollutants
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50. Zhang X, Zhang Z, Chen G, Zhao M, Wang D, Zhang X, Du Z, Xu Y, Yu X: FK228 induces mitotic catastrophe in A549 cells by mistargeting chromosomal passenger complex localization through changing centromeric H3K9 hypoacetylation. Acta Biochim Biophys Sin (Shanghai); 2010 Oct;42(10):677-87
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  • Previous studies have shown that histone deacetylase inhibitors (HDACis) can kill cancer cells.
  • In addition, HDACis can induce mitotic catastrophe in cancer cells due to insufficient localization of chromosomal passenger complex (CPC) to the centromere.
  • These epigenetic changes implied that H3K9 hyperacetylation inhibits the CPC recruitment, induces impaired centromere assembly and function, and eventually leads to aberrant mitosis.
  • These data suggested that hypoacetylation of histone in the pericentromere is the most important landmark for recruiting CPC and leading to the mitotic catastrophe in HDACi-induced killing of cancer cells.

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  • (PMID = 20817931.001).
  • [ISSN] 1745-7270
  • [Journal-full-title] Acta biochimica et biophysica Sinica
  • [ISO-abbreviation] Acta Biochim. Biophys. Sin. (Shanghai)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Autoantigens; 0 / Chromosomal Proteins, Non-Histone; 0 / Depsipeptides; 0 / Histones; 0 / centromere protein A; 452VLY9402 / Serine; CX3T89XQBK / romidepsin; K3Z4F929H6 / Lysine
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51. Martínez-Martínez I, Montoro-García S, Lozada-Ramírez JD, Sánchez-Ferrer A, García-Carmona F: A colorimetric assay for the determination of acetyl xylan esterase or cephalosporin C acetyl esterase activities using 7-amino cephalosporanic acid, cephalosporin C, or acetylated xylan as substrate. Anal Biochem; 2007 Oct 15;369(2):210-7
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  • A bromothymol blue-based colorimetric assay has been devised to screen for acetyl xylan esterase or cephalosporin C (CPC) deacetylase activities using 7-amino cephalosporanic acid (7-ACA), CPC, or acetylated xylan as substrate.
  • Similar K(M) values for 7-ACA and CPC were obtained when compared with those described using HPLC methods.

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  • (PMID = 17651681.001).
  • [ISSN] 0003-2697
  • [Journal-full-title] Analytical biochemistry
  • [ISO-abbreviation] Anal. Biochem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cephalosporins; 0 / Xylans; 3XIY7HJT5L / cephalosporin C; 9XI67897RG / 7-aminocephalosporanic acid; EC 3.1.1.6 / Acetylesterase; EC 3.1.1.72 / acetylxylan esterase
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52. Youn CS, Choi SP, Yim HW, Park KN: Out-of-hospital cardiac arrest due to drowning: An Utstein Style report of 10 years of experience from St. Mary's Hospital. Resuscitation; 2009 Jul;80(7):778-83
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  • We report on the largest single-center study of the Utstein Style resuscitation for drowning.
  • RESULTS: We enrolled 131 patients with OHCA due to drowning; 21 patients (16.03%) had survival to discharge and 9 patients (6.87%) were discharged with a good neurologic outcome, i.e., cerebral performance categories (CPC) of 1 or 2.
  • CONCLUSIONS: Our report is the largest single-center study of OHCA due to drowning reported according to the guidelines of the Utstein Style.

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  • (PMID = 19443097.001).
  • [ISSN] 1873-1570
  • [Journal-full-title] Resuscitation
  • [ISO-abbreviation] Resuscitation
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
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53. Watson T, Shantsila E, Karthikeyan VJ, Jessani S, Goon PK, Lip GY: The effects of exercise stress testing, diurnal variation and temporal decline on circulating progenitor cells. Thromb Haemost; 2010 Feb;103(2):419-25
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  • Given that the mature endothelial cells have limited capacity for self regeneration, circulating progenitor cells (CPCs) may modulate the balance between vascular damage and regeneration.
  • The three aims of the present study were 1) to define the influence of exercise treadmill testing (ETT) on peripheral CPC levels;.
  • 2) to assess the diurnal variation of CPC counts; and 3) to investigate the rate of temporal decline in CPCs once ex vivo .
  • The dynamics of CPC count changes following an ETT were assessed on consecutive 20 patients referred to our 'rapid-access' chest pain clinic (70% male, age 69.9 +/- 7.8) with venous blood samples taken pre-exercise, immediately post-exercise and at 30 minutes post-exercise.
  • Diurnal variation in CPCs was assessed in 13 stable in-hospital patients (46% male, age 69.1 +/- 7.5 years) with blood samples were taken five times every 6 hours.
  • To investigate the temporal decline, blood samples from 12 patients (58.3% male, age 69.9 +/- 7.9 years) were reprocessed for CPC counts at 4 hours and at 24 hours after sample collection.
  • CPCs were enumerated with flow cytometry as CD34+, CD133+, CD45dim events.
  • Exercise led to significant increases in vWF and sE-selectin levels, but no significant influence on CPC counts were observed.
  • Baseline CPC numbers demonstrated a negative correlation with vWf (r=-0.551, p=0.012) and sE-selectin levels (r=-0.494, p=0.027).
  • CPC counts showed a significant diurnal variation, being significantly higher at 12 a.m. compared to 12 p.m. (p=0.046) and 6 p.m. (p=0.023).
  • A 4 hour delay in sample preparation did not affect CPCs counts, but there was a significant decline in CPC recovery when sample processing was delayed by 24 hours (p<0.05).
  • Routine exercise stress testing does not significantly affect CPC counts.
  • Peripheral CPC levels showed a significant diurnal variation.
  • Delays in sample preparation for CPC counts should be avoided as they may influence the accuracy of the test by resulting in a significant decline in CPC recovery.
  • Thus, various factors may affect accuracy of CPC enumeration that may limit their role as a reliable clinical marker and biomarker of endothelial damage.

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  • (PMID = 20126832.001).
  • [ISSN] 0340-6245
  • [Journal-full-title] Thrombosis and haemostasis
  • [ISO-abbreviation] Thromb. Haemost.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers
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54. Hassanzadeh A, Zeini-Isfahani A, Habibi MH: Molecular exciton theory calculations based on experimental results for Solophenyl red 3BL azo dye-surfactants interactions. Spectrochim Acta A Mol Biomol Spectrosc; 2006 May 15;64(2):464-76
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  • The influence of anionic surfactant: sodium dodecyl sulfate (SDS) and cationic surfactants: cetyltrimethylammonium bromides (C16TAB) and cetylpyridinium chloride (CPC) on the electronic spectrum of Solophenyl red 3BL azo dye (C.I.
  • Further results showed that dye H-aggregation was occurred under the cationic surfactant CPC as well, but in this case micelle formation could not occur.
  • Addition of CPC surfactant into the J-aggregate dye solution in highly acidic aqueous solution was also caused completely disaggregating of dimer molecules, which may be related to occuring an acid-base reaction between them.
  • Applicability of the molecular exciton (Kasha) theory in order to interpret of aggregation results and to estimate dimer structure of 3BL dye under C16TAB and CPC surfactants addition was very poor and the calculated data based on this model showed that this simple point-dipole model could not describe our experimental results.

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  • (PMID = 16644265.001).
  • [ISSN] 1386-1425
  • [Journal-full-title] Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
  • [ISO-abbreviation] Spectrochim Acta A Mol Biomol Spectrosc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anions; 0 / Azo Compounds; 0 / Cations; 0 / Cetrimonium Compounds; 0 / Hydrazones; 0 / Solophenyl red 3BL; 0 / Surface-Active Agents; 368GB5141J / Sodium Dodecyl Sulfate; CUB7JI0JV3 / Cetylpyridinium; Z7FF1XKL7A / cetrimonium
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55. Radomski N, Cambau E, Moulin L, Haenn S, Moilleron R, Lucas FS: Comparison of culture methods for isolation of nontuberculous mycobacteria from surface waters. Appl Environ Microbiol; 2010 Jun;76(11):3514-20
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  • We compared the competitive growth of Mycobacterium chelonae and M. avium with nontarget microorganisms on rich Middlebrook 7H11-mycobactin medium after treatment by several chemical decontamination methods that included acids, bases, detergent, or cetylpyridinium chloride (CPC) with and without an antibiotic cocktail, either PANTA (40 U/ml polymyxin, 4 microg/ml amphotericin B, 16 microg/ml nalidixic acid, 4 microg/ml trimethoprim, and 4 microg/ml azlocillin) or PANTAV (PANTA plus 10 microg/ml vancomycin).
  • Our results showed that treatment for 30 min with CPC (final concentration, 0.05%) of water concentrated by centrifugation, followed by culture on a rich medium supplemented with PANTA, significantly decreased the growth of nontarget microorganisms (the concentrations were 6.2 +/- 0.4 log(10) CFU/liter on Middlebrook 7H11j medium and 4.2 +/- 0.2 log(10) CFU/liter on Middlebrook 7H11j medium containing PANTA [P < 0.001]), while the effect of this procedure on NTM was not as great (the concentrations of M. chelonae on the two media were 7.0 +/- 0.0 log(10) CFU/liter and 6.9 +/- 0.0 log(10) CFU/liter, respectively, and the concentrations of M. avium were 9.1 +/- 0.0 log(10) CFU/liter and 8.9 +/- 0.0 log(10) CFU/liter, respectively).

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  • (PMID = 20363776.001).
  • [ISSN] 1098-5336
  • [Journal-full-title] Applied and environmental microbiology
  • [ISO-abbreviation] Appl. Environ. Microbiol.
  • [Language] eng
  • [Databank-accession-numbers] GENBANK/ FJ770974/ FJ770975/ FJ770976/ FJ770977/ FJ770978/ FJ770979/ FJ770980/ FJ770981/ FJ770982/ FJ770983/ FJ770984/ FJ770985/ FJ770986/ FJ770987/ FJ770988/ FJ770989/ FJ770990/ FJ770991/ FJ770992/ FJ770993/ FJ770994/ FJ770995/ FJ770996/ FJ770997/ FJ770998/ FJ770999
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Culture Media; 0 / DNA, Bacterial; 0 / DNA, Ribosomal; 0 / RNA, Ribosomal, 16S
  • [Other-IDs] NLM/ PMC2876437
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56. Leary M, Fried DA, Gaieski DF, Merchant RM, Fuchs BD, Kolansky DM, Edelson DP, Abella BS: Neurologic prognostication and bispectral index monitoring after resuscitation from cardiac arrest. Resuscitation; 2010 Sep;81(9):1133-7
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  • METHODS: We prospectively collected BIS data in consecutive patients initially resuscitated from cardiac arrest and treated with TH in one academic medical center.
  • We assessed BIS values in context of cerebral performance category (CPC) assessment on the day of discharge.
  • Mean BIS values at 24 h post-resuscitation were significantly different in the survivors with CPC 1-2 ("good" outcome) vs those with CPC 3-5 ("poor" outcome) or death during hospitalization (49+/-13 vs 30+/-20; p<0.001).
  • Receiver operator characteristic analysis suggested that 24 h BIS was most predictive of CPC 1-2 outcome compared to the other timepoints; a BIS cutpoint of 45 exhibited a sensitivity of 63% and a specificity of 86%, with a positive likelihood ratio of 4.67.
  • [MeSH-major] Cardiopulmonary Resuscitation. Electroencephalography. Heart Arrest / diagnosis. Heart Arrest / therapy. Monitoring, Physiologic / methods. Nervous System / physiopathology

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  • [Copyright] Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 20598422.001).
  • [ISSN] 1873-1570
  • [Journal-full-title] Resuscitation
  • [ISO-abbreviation] Resuscitation
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
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57. Ikeda A, Shiotani A, Mori Y, Fujimine T, Tomifuji M, Takaoka T, Kameyama K, Ogawa K: Suitability of calcium phosphate cement for injection laryngoplasty in rabbits. ORL J Otorhinolaryngol Relat Spec; 2006;68(2):103-9
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  • Calcium phosphate cement (CPC) consists of powder and liquid, which become an injectable paste after mixing, self-hardening and recrystallizing to calcium hydroxylapatite (CaHA) after injection into a living body.
  • In this study, we investigated the suitability of CPC as an injectable material for injection laryngoplasty using rabbits.
  • All rabbits underwent left recurrent laryngeal nerve section and injection laryngoplasty with CPC.
  • At 7 days, scanning electron microscopic findings revealed that complete recrystallization from CPC to CaHA was achieved in the larynx.
  • At 1, 3, and 6 months, injected CPC stayed in the paraglottic space and did not migrate, and the average remaining CPC volume percentage was 91.7%.
  • Focal foreign body reaction to injected CPC was almost the same as that of autologous fat for all time periods observed.
  • These results indicated that CPC appears to be biocompatible, nonabsorbable, nonmigratory, and suitable for injection laryngoplasty.

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  • [Copyright] Copyright 2006 S. Karger AG, Basel.
  • (PMID = 16446556.001).
  • [ISSN] 0301-1569
  • [Journal-full-title] ORL; journal for oto-rhino-laryngology and its related specialties
  • [ISO-abbreviation] ORL J. Otorhinolaryngol. Relat. Spec.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Biocompatible Materials; 0 / Calcium Phosphates; 97Z1WI3NDX / calcium phosphate
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58. Rota M, LeCapitaine N, Hosoda T, Boni A, De Angelis A, Padin-Iruegas ME, Esposito G, Vitale S, Urbanek K, Casarsa C, Giorgio M, Lüscher TF, Pelicci PG, Anversa P, Leri A, Kajstura J: Diabetes promotes cardiac stem cell aging and heart failure, which are prevented by deletion of the p66shc gene. Circ Res; 2006 Jul 7;99(1):42-52
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  • Oxidative stress is enhanced with diabetes and oxygen toxicity may alter cardiac progenitor cell (CPC) function resulting in defects in CPC growth and myocyte formation, which may favor premature myocardial aging and heart failure.
  • We report that in a model of insulin-dependent diabetes mellitus, the generation of reactive oxygen species (ROS) leads to telomeric shortening, expression of the senescent associated proteins p53 and p16INK4a, and apoptosis of CPCs, impairing the growth reserve of the heart.
  • However, ablation of the p66shc gene prevents these negative adaptations of the CPC compartment, interfering with the acquisition of the heart senescent phenotype and the development of heart failure with diabetes.
  • CPC replication predominates in diabetic p66shc-/-, whereas CPC apoptosis and myocyte apoptosis and necrosis prevail in diabetic wild type.
  • Expansion of CPCs and developing myocytes preserves cardiac function in diabetic p66shc-/-, suggesting that intact CPCs can effectively counteract the impact of uncontrolled diabetes on the heart.
  • The recognition that p66shc conditions the destiny of CPCs raises the possibility that diabetic cardiomyopathy is a stem cell disease in which abnormalities in CPCs define the life and death of the heart.
  • Together, these data point to a genetic link between diabetes and ROS, on the one hand, and CPC survival and growth, on the other.

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  • [CommentIn] Circ Res. 2006 Jul 7;99(1):1-2 [16825582.001]
  • (PMID = 16763167.001).
  • [ISSN] 1524-4571
  • [Journal-full-title] Circulation research
  • [ISO-abbreviation] Circ. Res.
  • [Language] eng
  • [Grant] United States / NIA NIH HHS / AG / AG-17042; United States / NIA NIH HHS / AG / AG-23071; United States / NIA NIH HHS / AG / AG-26107; United States / NHLBI NIH HHS / HL / HL-38132; United States / NHLBI NIH HHS / HL / HL-65573; United States / NHLBI NIH HHS / HL / HL-65577; United States / NHLBI NIH HHS / HL / HL-75480; United States / NHLBI NIH HHS / HL / HL-78825; United States / NHLBI NIH HHS / HL / HL-81737
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Reactive Oxygen Species; 0 / Shc Signaling Adaptor Proteins; 0 / Shc1 protein, mouse
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59. Mandraffino G, Sardo MA, Riggio S, D'Ascola A, Loddo S, Alibrandi A, Saitta C, Imbalzano E, Mandraffino R, Venza M, Mormina EM, David A, Saitta A: Smoke exposure and circulating progenitor cells: evidence for modulation of antioxidant enzymes and cell count. Clin Biochem; 2010 Dec;43(18):1436-42
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  • BACKGROUND: Cigarette smoking is involved in vascular inflammation and impairment of circulating progenitor cells (CPCs), including endothelial progenitor cells (EPCs).
  • CPC and EPC correlated with HDL-C, CRP, ROS and enzyme expression and activity.
  • CONCLUSIONS: Our data suggest that smoking exposure involves antioxidant enzymes in CPCs and EPCs and that the inflammatory response in smokers plays an important role in impairing cells and their antioxidant functions.

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  • [Copyright] Copyright © 2010 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20888331.001).
  • [ISSN] 1873-2933
  • [Journal-full-title] Clinical biochemistry
  • [ISO-abbreviation] Clin. Biochem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antioxidants; 0 / Nitrites; 0 / Reactive Oxygen Species; 0 / Smoke; EC 1.11.1.- / glutathione peroxidase GPX1; EC 1.11.1.6 / Catalase; EC 1.11.1.9 / Glutathione Peroxidase; EC 1.15.1.1 / Superoxide Dismutase
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60. Colina-Márquez J, Machuca-Martínez F, Li Puma G: Radiation absorption and optimization of solar photocatalytic reactors for environmental applications. Environ Sci Technol; 2010 Jul 1;44(13):5112-20
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  • Ray tracing technique was coupled with the six-flux absorption scattering model (SFM) to analyze the complex radiation field in solar compound parabolic collectors (CPC) and tubular photoreactors.
  • The CPC has on average 70% higher photon absorption efficiency than a tubular reactor and requires 39% less catalyst to operate under optimum conditions.
  • The "apparent optical thickness" is proposed as a new dimensionless parameter for optimization of CPC and tubular reactors.
  • For titanium dioxide (TiO(2)) Degussa P25, maximum photon absorption occurs at apparent optical thicknesses of 7.78 for CPC and 12.97 for tubular reactors.

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  • (PMID = 20527954.001).
  • [ISSN] 0013-936X
  • [Journal-full-title] Environmental science & technology
  • [ISO-abbreviation] Environ. Sci. Technol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 15FIX9V2JP / titanium dioxide; D1JT611TNE / Titanium
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61. Cheong JH, Kim CY, Kim J: Preparative isolation and purification of sinomenine from Sinomenium acutum by centrifugal partition chromatography. J Sep Sci; 2007 Aug;30(13):2105-8
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  • Preparative centrifugal partition chromatography (CPC) was successfully carried out for the separation of sinomenine from the methanolic extract of Sinomenium acutum stems and rhizomes.
  • The optimum two-phase solvent system of CPC was composed of n-hexane/ethyl acetate/methanol/water at a volume ratio of 1:6:2:8 (v/v/v/v) with 0.1% triethylamine (TEA).
  • Preparative CPC yielded 44.3 mg of sinomenine from 400 mg of MeOH extract with a purity of 96.9%.

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  • (PMID = 17654620.001).
  • [ISSN] 1615-9306
  • [Journal-full-title] Journal of separation science
  • [ISO-abbreviation] J Sep Sci
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Morphinans; 0 / Plant Extracts; 0 / Solvents; S04A852S5I / sinomenine
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62. Glick TH: Toward a more efficient and effective neurologic examination for the 21st century. Eur J Neurol; 2005 Dec;12(12):994-7
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  • I analyzed 100 published, neurologic clinicopathologic conferences (CPCs) and 180 ambulatory neurologic consultations regarding 13 hypothetically 'marginal' examination components (including 'frontal' reflexes, olfaction, jaw strength, corneal reflex, etc.
  • In the CPCs the 'marginal' elements of the examination were rarely provided, requested, or used diagnostically, nor did they contribute in the 180 ambulatory consultations.
  • [MeSH-major] Nervous System Diseases / diagnosis. Neurologic Examination / standards. Neurologic Examination / statistics & numerical data. Neurology / standards

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  • (PMID = 16324094.001).
  • [ISSN] 1351-5101
  • [Journal-full-title] European journal of neurology
  • [ISO-abbreviation] Eur. J. Neurol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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63. Zhu HF, Fitzsimmons K, Khandelwal A, Kranz RG: CPC, a single-repeat R3 MYB, is a negative regulator of anthocyanin biosynthesis in Arabidopsis. Mol Plant; 2009 Jul;2(4):790-802
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  • [Title] CPC, a single-repeat R3 MYB, is a negative regulator of anthocyanin biosynthesis in Arabidopsis.
  • Single-repeat R3 MYB transcription factors like CPC (CAPRICE) are known to play roles in developmental processes such as root hair differentiation and trichome initiation.
  • We show here that CPC is a negative regulator of anthocyanin biosynthesis.
  • In the process of using CPC to test GAL4-dependent driver lines, we observed a repression of anthocyanin synthesis upon GAL4-mediated CPC overexpression.
  • Rather, CPC expression level tightly controls anthocyanin accumulation.
  • Microarray analysis on the whole genome showed that, of 37 000 features tested, 85 genes are repressed greater than three-fold by CPC overexpression.
  • Also, anthocyanin synthesis genes were shown to be down-regulated in 35S::CPC overexpression plants.
  • Transient expression results suggest that CPC competes with the R2R3-MYB transcription factor PAP1/2, which is an activator of anthocyanin biosynthesis genes.
  • This report adds anthocyanin biosynthesis to the set of programs that are under CPC control, indicating that this regulator is not only for developmental programs (e.g. root hairs, trichomes), but can influence anthocyanin pigment synthesis.

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  • (PMID = 19825656.001).
  • [ISSN] 1674-2052
  • [Journal-full-title] Molecular plant
  • [ISO-abbreviation] Mol Plant
  • [Language] eng
  • [Databank-accession-numbers] GENBANK/ FJ268773
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anthocyanins; 0 / Arabidopsis Proteins; 0 / CPC protein, Arabidopsis; 0 / Proto-Oncogene Proteins c-myb
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64. Navntoft C, Ubomba-Jaswa E, McGuigan KG, Fernández-Ibáñez P: Effectiveness of solar disinfection using batch reactors with non-imaging aluminium reflectors under real conditions: Natural well-water and solar light. J Photochem Photobiol B; 2008 Dec 11;93(3):155-61
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  • Inactivation kinetics are reported for suspensions of Escherichia coli in well-water using compound parabolic collector (CPC) mirrors to enhance the efficiency of solar disinfection (SODIS) for batch reactors under real, solar radiation (cloudy and cloudless) conditions.
  • On clear days, the system with CPC reflectors achieved complete inactivation (more than 5-log unit reduction in bacterial population to below the detection limit of 4CFU/mL) one hour sooner than the system fitted with no CPC.
  • On cloudy days, only systems fitted with CPCs achieved complete inactivation.
  • The reflectivity of CPC systems that had been in use outdoors for at least 3 years deteriorated in a non-homogeneous fashion.
  • Reflectivity values for these older systems were found to vary between 27% and 72% compared to uniform values of 87% for new CPC systems.
  • The use of CPC has been proven to be a good technological enhancement to inactivate bacteria under real conditions in clear and cloudy days.

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  • (PMID = 18835188.001).
  • [ISSN] 1011-1344
  • [Journal-full-title] Journal of photochemistry and photobiology. B, Biology
  • [ISO-abbreviation] J. Photochem. Photobiol. B, Biol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] CPD4NFA903 / Aluminum
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65. Liu Y, Liu M, Ren P: [Drug delivery of CPC/cisplatin complex in vitro and its ability to repair bone defect and eliminate tumor in vivo]. Zhong Nan Da Xue Xue Bao Yi Xue Ban; 2009 Oct;34(10):991-7
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  • [Title] [Drug delivery of CPC/cisplatin complex in vitro and its ability to repair bone defect and eliminate tumor in vivo].
  • OBJECTIVE: To explore the best mass ratio of calcium phosphate cement (CPC)/cisplatin complex filling and to repair bone defect caused by tumor resection.
  • We implanted CPC and CPC/cisplatin complex to observe the repair of bone defect and the inhibition of tumor in vivo.
  • RESULTS: CPC containing 0.1% approximately 0.2% cisplatin not only repaired the bone defect in rabbits but also eliminated osteosarcoma in rats.
  • CONCLUSION: CPC containing 0.1% approximately 0.2% cisplatin can repair bone defect and eliminate tumor without influencing the prosthetic precess.

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  • (PMID = 19893250.001).
  • [ISSN] 1672-7347
  • [Journal-full-title] Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
  • [ISO-abbreviation] Zhong Nan Da Xue Xue Bao Yi Xue Ban
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biocompatible Materials; 0 / Bone Cements; 0 / Bone Substitutes; 0 / Calcium Phosphates; 0 / Delayed-Action Preparations; 701EKV9RMN / calcium phosphate, monobasic, anhydrous; Q20Q21Q62J / Cisplatin
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66. Tomanee P, Hsu JT, Ito Y: Preparative fractionation of protein, RNA, and plasmid DNA using centrifugal precipitation chromatography with tubular dialysis membrane inside a convoluted tubing as separation channel. Biotechnol Prog; 2006 Mar-Apr;22(2):532-7
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  • Fractionation of clarified E. coli lysate components in bench-scale and preparative-scale centrifugal precipitation chromatography (CPC), using a solution of cationic surfactant cetyltrimethylammonium bromide (CTAB) containing 0.5 M NaCl as precipitant, are compared here.
  • Step gradient of CTAB from 0.50% to 0.16% (w/v) gave a successful fractionation in bench-scale CPC; however, a linear gradient of lower CTAB concentration, 0.20-0% (w/v), was used in the preparative scale and resulted in similar fractionation.
  • The preparative-scale CPC has a superior sample loading capacity by the use of tubular dialysis membrane inside convoluted tubing as the separation channel.
  • In this study, the quantity of the sample loaded into the preparative CPC was about 15 times more than that in the bench scale, and in a single run the preparative CPC could prepare approximately 3 mg of plasmid DNA with about 96% of RNA removed.
  • The higher surface area per length of the separation channel in the preparative CPC was believed to benefit mass transfer of CTAB across the membrane, leading to less CTAB being required in the process.

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  • (PMID = 16599573.001).
  • [ISSN] 8756-7938
  • [Journal-full-title] Biotechnology progress
  • [ISO-abbreviation] Biotechnol. Prog.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Proteins; 63231-63-0 / RNA; 9007-49-2 / DNA
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67. Fransén N, Morin M, Björk E, Edsman K: Physicochemical interactions between drugs and superdisintegrants. J Pharm Pharmacol; 2008 Dec;60(12):1583-9
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  • The binding of sodium salicylate, naproxen, methyl hydroxybenzoate (methylparaben), ethyl hydroxybenzoate (ethylparaben), propyl hydroxybenzoate (propylparaben), atenolol, alprenolol, diphenhydramine, verapamil, amitriptyline and cetylpyridinium chloride monohydrate (CPC) to different superdisintegrants (sodium starch glycolate (SSG), croscarmellose sodium (CCS) and crospovidone) and one unsubstituted comparator (starch) was studied spectrophotometrically.

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  • (PMID = 19000362.001).
  • [ISSN] 0022-3573
  • [Journal-full-title] The Journal of pharmacy and pharmacology
  • [ISO-abbreviation] J. Pharm. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Excipients; 0 / Pharmaceutical Preparations; 451W47IQ8X / Sodium Chloride; 9003-39-8 / Povidone; 9004-32-4 / Carboxymethylcellulose Sodium; 9005-25-8 / Starch; 9063-38-1 / sodium starch glycolate
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68. Hadjipanayis CG, Van Meir EG: Brain cancer propagating cells: biology, genetics and targeted therapies. Trends Mol Med; 2009 Nov;15(11):519-30
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  • [Title] Brain cancer propagating cells: biology, genetics and targeted therapies.
  • Cancer propagating cells (CPCs) within primary central nervous system (CNS) tumors (glioblastoma multiforme (GBM), medulloblastoma (MB) and ependymoma) might be integral to tumor development and perpetuation.
  • These cells, also known as brain cancer propagating cells (BCPCs), have the ability to self-renew and proliferate.

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  • (PMID = 19889578.001).
  • [ISSN] 1471-499X
  • [Journal-full-title] Trends in molecular medicine
  • [ISO-abbreviation] Trends Mol Med
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA086335; United States / NINDS NIH HHS / NS / NS053454-03; United States / NCI NIH HHS / CA / CA116804; United States / NINDS NIH HHS / NS / NS053454-02; United States / NINDS NIH HHS / NS / NS053454-01A1; United States / NINDS NIH HHS / NS / K08 NS053454-02; United States / NCI NIH HHS / CA / CA86335; United States / NINDS NIH HHS / NS / K08 NS053454; United States / NINDS NIH HHS / NS / K08 NS053454-03; United States / NCI NIH HHS / CA / R01 CA116804; United States / NINDS NIH HHS / NS / K08 NS053454-01A1; United States / NINDS NIH HHS / NS / NS053454-04; United States / NINDS NIH HHS / NS / NS053454; United States / NINDS NIH HHS / NS / K08 NS053454-04
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Number-of-references] 104
  • [Other-IDs] NLM/ NIHMS158864; NLM/ PMC2782740
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69. Yamamoto TM, Lewellyn AL, Maller JL: Regulation of the Aurora B chromosome passenger protein complex during oocyte maturation in Xenopus laevis. Mol Cell Biol; 2008 Jun;28(12):4196-203
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  • Resting G2 oocytes express inactive Aurora B that is not associated with other subunits of the chromosome passenger complex (CPC).
  • Activity increases near the time of germinal vesicle breakdown in progesterone-treated oocytes, and this increase is correlated with the synthesis of inner centromere protein (INCENP) and survivin, components of the CPC.
  • Prevention of the decrease in Aurora B activity at fertilization by expression of ectopic wild-type INCENP, but not kinase-dead Aurora B INCENP, blocked calcium-induced exit from metaphase arrest in egg extracts.

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  • (PMID = 18378691.001).
  • [ISSN] 1098-5549
  • [Journal-full-title] Molecular and cellular biology
  • [ISO-abbreviation] Mol. Cell. Biol.
  • [Language] ENG
  • [Grant] United States / Howard Hughes Medical Institute / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Xenopus Proteins; 4G7DS2Q64Y / Progesterone; EC 2.7.11.1 / Aurora Kinases; EC 2.7.11.1 / Protein-Serine-Threonine Kinases
  • [Other-IDs] NLM/ PMC2423128
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70. Maerki S, Olma MH, Staubli T, Steigemann P, Gerlich DW, Quadroni M, Sumara I, Peter M: The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis. J Cell Biol; 2009 Dec 14;187(6):791-800
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  • Interestingly, KLHL21 but not KLHL22 is necessary for cytokinesis and regulates translocation of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase, similar to the previously described BTB-Kelch proteins KLHL9 and KLHL13.

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  • (PMID = 19995937.001).
  • [ISSN] 1540-8140
  • [Journal-full-title] The Journal of cell biology
  • [ISO-abbreviation] J. Cell Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / CUL3 protein, human; 0 / Cullin Proteins; 0 / KLHL22 protein, human; 0 / Recombinant Fusion Proteins; 0 / Tubulin; EC 2.7.11.1 / AURKB protein, human; EC 2.7.11.1 / Aurora Kinase B; EC 2.7.11.1 / Aurora Kinases; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; EC 6.3.2.19 / Ubiquitin-Protein Ligases
  • [Other-IDs] NLM/ PMC2806313
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71. Prato-Garcia D, Buitrón G: Solar photoassisted advanced oxidation process of azo dyes. Water Sci Technol; 2009;59(5):965-72
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  • Advanced oxidation processes assisted with natural solar radiation in CPC type reactors (parabolic collector compound), was applied for the degradation of three azo dyes: acid orange (AO7), acid red 151 (AR151) and acid blue 113 (AB113).
  • Fenton, Fenton like and ferrioxalate-type complexes showed to be effective for degrade the azo linkage and moieties in different extensions.
  • In this work, it was also studied the effect of concentration changes of the influent between 100-300 mg/L and the operation of the photocatalytic process near neutral conditions (pH 6.0-6.5) by using ferrioxalate type complex (FeOx).

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  • (PMID = 19273895.001).
  • [ISSN] 0273-1223
  • [Journal-full-title] Water science and technology : a journal of the International Association on Water Pollution Research
  • [ISO-abbreviation] Water Sci. Technol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Azo Compounds
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72. Rodríguez-Morales S, Compadre RL, Castillo R, Breen PJ, Compadre CM: 3D-QSAR, synthesis, and antimicrobial activity of 1-alkylpyridinium compounds as potential agents to improve food safety. Eur J Med Chem; 2005 Sep;40(9):840-9
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  • Cetylpyridinium chloride (CPC), an alkylpyridinium compound has been recently approved by the US Food and Drug Administration to reduce bacterial contamination in poultry.
  • Although CPC is very effective and has a very good safety record, its relatively high lipophilicity may limit its use in high fat containing foods such as beef.

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  • (PMID = 16194718.001).
  • [ISSN] 0223-5234
  • [Journal-full-title] European journal of medicinal chemistry
  • [ISO-abbreviation] Eur J Med Chem
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Food Preservatives; 0 / Pyridinium Compounds
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73. Wu JY, Li CS, Liu ZX, Wu CJ, Zhang GC: A comparison of 2 types of chest compressions in a porcine model of cardiac arrest. Am J Emerg Med; 2009 Sep;27(7):823-9
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  • [Title] A comparison of 2 types of chest compressions in a porcine model of cardiac arrest.
  • OBJECTIVE: Chest compressions performed by some medical workers are of poor quality, which are too few and shallow with incomplete release.
  • This study was designed to compare the effects of these clinical quality chest compressions with standard manual chest compressions in a porcine model of cardiac arrest.
  • Animals of no restoration of spontaneous circulation after 4 times of defibrillations were announced dead and dissected immediately to observe the cerebral perfusion with methylene blue coloration.
  • (1) standard manual chest compressions group (n = 9)-chest compression rates were kept at 100 +/- 5 cpm and compression depth at 50 +/- 1 mm with complete release by Heartstart MRx Monitor;.
  • (2) clinical quality chest compressions group (n = 9)-chest compression rates were kept at 80 +/- 5 cpm and compression depth at 37 +/- 1 mm with incomplete release.
  • RESULTS: Compared with clinical quality chest compressions, standard manual chest compressions produced greater restoration of spontaneous circulation, neurologically normal 24-hour survival, and histopathologic findings.
  • CONCLUSIONS: High-quality chest compressions improve outcomes of resuscitation, especially postresuscitation brain damage.

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  • (PMID = 19683111.001).
  • [ISSN] 1532-8171
  • [Journal-full-title] The American journal of emergency medicine
  • [ISO-abbreviation] Am J Emerg Med
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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74. Liu Y, Gong G, Xie L, Yuan N, Zhu C, Zhu B, Hu Y: Improvement of cephalosporin C production by recombinant DNA integration in Acremonium chrysogenum. Mol Biotechnol; 2010 Feb;44(2):101-9
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  • For the purpose of increasing the yield of cephalosporin C (CPC) fermentation, especially in an industrial strain, A. chrysogenum genes cefEF and cefG, which encode the ultimate and penultimate steps in CPC biosynthesis, cefT, which encodes a CPC efflux pump, and vgb, which encodes a bacterial hemoglobin gene were transformed in various combinations into an industrial strain of A. chrysogenum.
  • HPLC analysis of fermentation broth of recombinant A. chrysogenum showed that most transformants had a higher CPC production level than the parental strain.
  • Multiple transformants containing an additional copy of cefG showed a significant increase in CPC production.
  • However, cefT showed little effect on CPC production in this high producer.
  • The highest improvement of CPC titer was observed in the mutant with an extra copy of cefG + cefEF + vgb whose CPC production was increased by 116.3%.
  • Our results also demonstrated that the combination of these genes had a synergy effect in a CPC high producer.

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  • (PMID = 19787461.001).
  • [ISSN] 1559-0305
  • [Journal-full-title] Molecular biotechnology
  • [ISO-abbreviation] Mol. Biotechnol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cephalosporins; 0 / DNA, Recombinant; 3XIY7HJT5L / cephalosporin C
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75. Schittenhelm J, Erdmann T, Maennlin S, Will BE, Beschorner R, Bornemann A, Meyermann R, Mittelbronn M: Gliosarcoma with chondroid and osseous differentiation. Neuropathology; 2007 Feb;27(1):90-4
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  • Neuroradiological examinations revealed a large left temporo-occipital cystic and calcified tumor mass measuring 6 cm in diameter, which was suspicious for an oligodendroglioma or a choroid plexus carcinoma.
  • The tumor demonstrated a biphasic pattern consisting of focal anaplastic glial components with vascular proliferation and necrosis.
  • Interestingly, in our case, the tumor exhibited features of both cartilaginous and osseous differentiation and multifocally showed a sharp transformation zone between highly malignant gliosarcomatous tumor areas and well-differentiated non-proliferative metaplastic regions.

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  • (PMID = 17319288.001).
  • [ISSN] 0919-6544
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein
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76. Xie Q, He A, Song K: [Experimental study of calcium phosphate cement mixed with bFGF and VEGF to repair bone defects in rabbit radius]. Zhong Nan Da Xue Xue Bao Yi Xue Ban; 2010 Jun;35(6):622-9
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  • These bone defect regions were implanted with corresponding composites: group A with calcium phosphate cement (CPC) only, group B with CPC/bFGF, group C with CPC/VEGF while group D with both bFGF and VEGF.
  • RESULTS: X-ray showed that at the 12th week the bone defects in group D were completely repaired with CPC generally degraded,whereas bone defects in group B and C were only basically repaired.
  • CONCLUSION: These 3 kinds of composite: CPC/bFGF, CPC/VEGF and CPC/ bFGF+VEGF can promote the growth of bone tissue and speed up the repair of bone defects.
  • The composite of CPC/bFGF+VEGF is better than the other two composites in promoting the growth of bone tissues, indicating that bFGF and VEGF have a synergistic effect on the growth of bone tissue.

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  • (PMID = 20622337.001).
  • [ISSN] 1672-7347
  • [Journal-full-title] Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
  • [ISO-abbreviation] Zhong Nan Da Xue Xue Bao Yi Xue Ban
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Bone Cements; 0 / Calcium Phosphates; 0 / Vascular Endothelial Growth Factor A; 103107-01-3 / Fibroblast Growth Factor 2; 97Z1WI3NDX / calcium phosphate
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77. Shing CM, Peake JM, Suzuki K, Jenkins DG, Coombes JS: Bovine colostrum modulates cytokine production in human peripheral blood mononuclear cells stimulated with lipopolysaccharide and phytohemagglutinin. J Interferon Cytokine Res; 2009 Jan;29(1):37-44
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  • The aim of this investigation was to determine the influence of a commercially available bovine colostrum protein concentrate (CPC) to stimulate cytokine production by human peripheral blood mononuclear cells (PBMCs).
  • PBMCs were separated and cultured with bovine CPC concentrations of 0 (control), 1.25, 2.5, and 5% with and without lipopolysaccharide (LPS) (3 microg/mL) and phytohemagglutinin (PHA) (2.5 microg/mL).
  • Bovine CPC significantly stimulated the release of IFN-gamma, IL-10, and IL-2 (p < 0.03).
  • The addition of LPS to PBMCs cocultured with bovine CPC significantly stimulated the release of IL-2 and inhibited the early release of TNF, IL-6, and IL-4 (p < 0.02).
  • Phytohemagglutinin stimulation in combination with bovine CPC significantly increased the secretion of IL-10 and IL-2 at 6 h of culture and inhibited IFN-gamma and TNF (p < 0.05).
  • This data show that a commercial bovine CPC is able to modulate in vitro cytokine production of human PBMCs.

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  • (PMID = 19014336.001).
  • [ISSN] 1557-7465
  • [Journal-full-title] Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research
  • [ISO-abbreviation] J. Interferon Cytokine Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cytokines; 0 / Lipopolysaccharides; 0 / Mitogens; 0 / Phytohemagglutinins
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78. Hornick JE, Karanjeet K, Collins ES, Hinchcliffe EH: Kinesins to the core: The role of microtubule-based motor proteins in building the mitotic spindle midzone. Semin Cell Dev Biol; 2010 May;21(3):290-9
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  • This region recruits several key central spindle components: PRC-1, polo-like kinase 1 (Plk-1), the centralspindlin complex, and the chromosome passenger complex (CPC), which together serve to stabilize the microtubule overlap, and also to coordinate the assembly of the cortical actin/myosin cytoskeleton necessary to physically cleave the cell in two.

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  • [Copyright] Copyright 2010 Elsevier Ltd. All rights reserved.
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  • (PMID = 20109573.001).
  • [ISSN] 1096-3634
  • [Journal-full-title] Seminars in cell & developmental biology
  • [ISO-abbreviation] Semin. Cell Dev. Biol.
  • [Language] eng
  • [Grant] United States / NIGMS NIH HHS / GM / R01 GM072754; United States / NIGMS NIH HHS / GM / R01 GM072754; United States / NCI NIH HHS / CA / T32 CA080621
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Actins; 0 / Cell Cycle Proteins; 0 / Microtubule Proteins; 0 / Proto-Oncogene Proteins; 9013-26-7 / Actomyosin; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; EC 2.7.11.1 / polo-like kinase 1; EC 3.6.1.- / Kinesin
  • [Number-of-references] 116
  • [Other-IDs] NLM/ NIHMS177894; NLM/ PMC3951275
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79. Judkins AR, Burger PC, Hamilton RL, Kleinschmidt-DeMasters B, Perry A, Pomeroy SL, Rosenblum MK, Yachnis AT, Zhou H, Rorke LB, Biegel JA: INI1 protein expression distinguishes atypical teratoid/rhabdoid tumor from choroid plexus carcinoma. J Neuropathol Exp Neurol; 2005 May;64(5):391-7
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  • [Title] INI1 protein expression distinguishes atypical teratoid/rhabdoid tumor from choroid plexus carcinoma.
  • Central nervous system atypical teratoid/rhabdoid tumor (AT/RT) and choroid plexus carcinoma (CPC) are rare, highly malignant tumors that predominantly arise in infants and young children.
  • Overlapping clinical, histologic, ultrastructural, or immunophenotypic features may obscure the diagnosis in some cases.
  • Mutations of INI1 in some CPCs have been reported.
  • The purpose of the present study was to determine if immunohistochemical staining with an INI1 antibody would provide a sensitive means of distinguishing between CPC and AT/RT.
  • We examined 28 tumors with a submitted diagnosis of CPC.
  • Twenty-one CPCs showed retained expression of INI1 and seven tumors showed loss of INI1 expression.
  • In three of the seven cases, monosomy 22 was the only cytogenetic abnormality, suggestive of AT/RT.
  • Immunostaining for INI1 protein is retained in the majority of CPC and is lost in AT/RT.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Carcinoma / metabolism. Choroid Plexus Neoplasms / metabolism. DNA-Binding Proteins / metabolism. Gene Expression Regulation, Neoplastic / physiology. Teratoma / metabolism

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  • (PMID = 15892296.001).
  • [ISSN] 0022-3069
  • [Journal-full-title] Journal of neuropathology and experimental neurology
  • [ISO-abbreviation] J. Neuropathol. Exp. Neurol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA46274; United States / NCI NIH HHS / CA / CA98543
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chromosomal Proteins, Non-Histone; 0 / DNA-Binding Proteins; 0 / Mucin-1; 0 / SMARCB1 protein, human; 0 / Transcription Factors
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80. Fletcher GF, Mills WC, Taylor WC: Update on exercise stress testing. Am Fam Physician; 2006 Nov 15;74(10):1749-54
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  • Ten categories from the ACC/ AHA 1997 guidelines were modified: ST heart rate adjustment, unstable angina, older patients, acute coronary syndromes, chest pain centers, acute myocardial infarction, asymptomatic patients, valvular heart disease, rhythm disturbances, and hypertension.
  • Intermediate- and low-risk patients with unstable angina, acute coronary syndromes, or chest pain should undergo exercise stress testing when clinically stable.
  • [MeSH-major] Exercise Test. Heart Diseases / diagnosis
  • [MeSH-minor] Age Factors. Humans. Hypertension / diagnosis. Practice Guidelines as Topic. Risk

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  • (PMID = 17137006.001).
  • [ISSN] 0002-838X
  • [Journal-full-title] American family physician
  • [ISO-abbreviation] Am Fam Physician
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 25
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81. Castrén M, Nordberg P, Svensson L, Taccone F, Vincent JL, Desruelles D, Eichwede F, Mols P, Schwab T, Vergnion M, Storm C, Pesenti A, Pachl J, Guérisse F, Elste T, Roessler M, Fritz H, Durnez P, Busch HJ, Inderbitzen B, Barbut D: Intra-arrest transnasal evaporative cooling: a randomized, prehospital, multicenter study (PRINCE: Pre-ROSC IntraNasal Cooling Effectiveness). Circulation; 2010 Aug 17;122(7):729-36
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  • [Title] Intra-arrest transnasal evaporative cooling: a randomized, prehospital, multicenter study (PRINCE: Pre-ROSC IntraNasal Cooling Effectiveness).
  • BACKGROUND: Transnasal evaporative cooling has sufficient heat transfer capacity for effective intra-arrest cooling and improves survival in swine.
  • The aim of this study was to determine the safety, feasibility, and cooling efficacy of prehospital transnasal cooling in humans and to explore its effects on neurologically intact survival to hospital discharge.
  • METHODS AND RESULTS: Witnessed cardiac arrest patients with a treatment interval <or=20 minutes were randomized to intra-arrest cooling with a RhinoChill device (treatment group, n=96) versus standard care (control group, n=104).
  • The final analysis included 93 versus 101 patients, respectively.
  • Both groups were cooled after hospital arrival.
  • The patients had similar demographics, initial rhythms, rates of bystander cardiopulmonary resuscitation, and intervals to cardiopulmonary resuscitation and arrival of advanced life support personnel.
  • Eighteen device-related adverse events (1 periorbital emphysema, 3 epistaxis, 1 perioral bleed, and 13 nasal discolorations) were reported.
  • Time to target temperature of 34 degrees C was shorter in the treatment group for both tympanic (102 versus 282 minutes, P=0.03) and core (155 versus 284 minutes, P=0.13) temperature.
  • There were no significant differences in rates of return of spontaneous circulation between the groups (38% in treated subjects versus 43% in control subjects, P=0.48), in overall survival of those admitted alive (44% versus 31%, respectively, P=0.26), or in neurologically intact survival to discharge (Pittsburgh cerebral performance category scale 1 to 2, 34% versus 21%, P=0.21), although the study was not adequately powered to detect changes in these outcomes.
  • CONCLUSIONS: Prehospital intra-arrest transnasal cooling is safe and feasible and is associated with a significant improvement in the time intervals required to cool patients.
  • [MeSH-major] Emergency Medical Services / methods. Heart Arrest / therapy. Hypothermia, Induced / instrumentation. Hypothermia, Induced / methods
  • [MeSH-minor] Administration, Intranasal. Aged. Body Temperature / physiology. Cold Temperature. Female. Humans. Male. Middle Aged. Prospective Studies. Time Factors

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  • [CommentIn] Circulation. 2010 Aug 17;122(7):679-81 [20679546.001]
  • (PMID = 20679548.001).
  • [ISSN] 1524-4539
  • [Journal-full-title] Circulation
  • [ISO-abbreviation] Circulation
  • [Language] eng
  • [Databank-accession-numbers] ClinicalTrials.gov/ NCT00808236
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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82. Ding T, Sun J, Zhang P: Immune evaluation of biomaterials in TNF-alpha and IL-1beta at mRNA level. J Mater Sci Mater Med; 2007 Nov;18(11):2233-6
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  • The PLGA, NPG, beta-TCP, and CPC groups also induced moderate TNF-alpha and IL1-beta expression (p < 0.01).
  • Our findings showed that beta-TCP and CPC had a good biocompability, and CPC was the most biocompatible of all the biomaterials tested.

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  • [Cites] Cardiovasc Res. 2002 Oct;56(1):126-34 [12237173.001]
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  • (PMID = 17705056.001).
  • [ISSN] 0957-4530
  • [Journal-full-title] Journal of materials science. Materials in medicine
  • [ISO-abbreviation] J Mater Sci Mater Med
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biocompatible Materials; 0 / Interleukin-1beta; 0 / Lipopolysaccharides; 0 / RNA, Messenger; 0 / Tumor Necrosis Factor-alpha
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83. Rajesh JB, Nandakumar K, Varma HK, Komath M: Calcium phosphate cement as a "barrier-graft" for the treatment of human periodontal intraosseous defects. Indian J Dent Res; 2009 Oct-Dec;20(4):471-9
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  • BACKGROUND: Calcium phosphate cements (CPC) are apparently good candidates for periodontal treatment by virtue of their biocompatibility, mouldability and osteoconductivity.
  • This study is aimed at the evaluation of the efficacy of a formulation of CPC in healing human periodontal intraosseous defects in comparison with hydroxyapatite ceramic granules.
  • The defect sites in the test groups were repaired with CPC and hydroxyapatite ceramic granules (HAG).
  • RESULTS: CPC showed significantly better outcome.
  • Probing depth reduction values of CPC, HAG and Control at 6 months were 5.40 +/- 1.43, 3.75 +/- 1.71 and 2.90 +/- 1.48, and those at 12 months were 6.20 +/- 1.80, 4.5 +/- 1.91 and 2.95 +/- 1.73.
  • Clinical attachment gain values of CPC, HAG and Control at 6 months were 5.15 +/- 1.50, 3.45 +/- 1.96 and 2.25 +/- 1.52, and those at 12 months were 5.80 +/- 2.02, 3.55 +/- 2.06 and 2.30 +/- 1.78, In both cases the P value was < 0.001 showing high significance.
  • The gingival recession over 12 months, for the CPC group is lesser than that in the HAG group and the value for the control group is marginally higher than both.

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  • (PMID = 20139574.001).
  • [ISSN] 1998-3603
  • [Journal-full-title] Indian journal of dental research : official publication of Indian Society for Dental Research
  • [ISO-abbreviation] Indian J Dent Res
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Biocompatible Materials; 0 / Bone Cements; 0 / Bone Substitutes; 0 / Calcium Phosphates; 91D9GV0Z28 / Durapatite; 97Z1WI3NDX / calcium phosphate
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84. Buzzega D, Pederzoli F, Maccari F, Aslan D, Türk M, Volpi N: Comparison of cetylpyridinium chloride and cetyltrimethylammonium bromide extractive procedures for quantification and characterization of human urinary glycosaminoglycans. Clin Chem Lab Med; 2010 Aug;48(8):1133-9
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  • Cetylpyridinium chloride (CPC) and cetyltrimethylammonium bromide (CETAB) are generally used to extract urinary GAGs prior to analysis.
  • In this study, we evaluated the extraction of human urinary GAGs using CPC in comparison with CETAB.
  • RESULTS: Differences were observed between CPC and CETAB extract protocols.
  • However, the heparan sulfate (HS) concentration was calculated to be approximately 3.3 times greater for CPC than CETAB.
  • When calculated in relative percentage, 33.6% HS was determined for CPC and 10.0% for CETAB.
  • These results show a quantitative expression for greater recovery of HS by using CPC protocol than CETAB.
  • In addition, no differences were observed for the CS disaccharide composition purified by using CPC or CETAB, and quite similar results were observed for 4s/6s disaccharide ratios and charge density values.
  • CONCLUSIONS: Extract procedures for urinary GAGs using CPC or CETAB are able to recover similar amounts of CS quantified by agarose-gel electrophoresis and HPLC.
  • However, CPC yields greater recovery of HS than the CETAB protocol; an increase of approximately 3.3 times as evaluated by electrophoresis.
  • This different capacity of HS extraction between CPC and CETAB should be considered when urinary GAGs of subjects affected by various diseases and related pharmacological treatments are considered, or meta-analysis is performed comparing various studies and trials performed under different experimental conditions.

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  • (PMID = 20441479.001).
  • [ISSN] 1437-4331
  • [Journal-full-title] Clinical chemistry and laboratory medicine
  • [ISO-abbreviation] Clin. Chem. Lab. Med.
  • [Language] ENG
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Cetrimonium Compounds; 0 / Glycosaminoglycans; 9007-28-7 / Chondroitin Sulfates; 9050-30-0 / Heparitin Sulfate; CUB7JI0JV3 / Cetylpyridinium; Z7FF1XKL7A / cetrimonium
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85. Matsumine A, Kusuzaki K, Matsubara T, Okamura A, Okuyama N, Miyazaki S, Shintani K, Uchida A: Calcium phosphate cement in musculoskeletal tumor surgery. J Surg Oncol; 2006 Mar 1;93(3):212-20
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  • BACKGROUND AND OBJECTIVES: Calcium phosphate cement (CPC) is an injectable biocompatible bone substitute that has been used for various applications in orthopedic surgery.
  • However, no extensive clinical studies of the use of CPC to fill bone cavities after curettage of musculoskeletal tumors have been reported.
  • The present study reviewed the results for 56 musculoskeletal tumors treated by curettage and CPC implantation.
  • Variables for clinical assessment included pain, limb function, and complications.
  • In all cases, CPC was radiographically well adapted to the surrounding host bone as of final follow-up.
  • CONCLUSIONS: CPC appears to offer a useful bone substitute for the treatment of musculoskeletal tumors.

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  • [CommentIn] J Surg Oncol. 2006 Mar 1;93(3):169-70 [16482592.001]
  • (PMID = 16482601.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bone Cements; 0 / Calcium Phosphates; 97Z1WI3NDX / calcium phosphate
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86. Fernández Calvo O, Gallegos Sancho MI, Quindós Varela M, Paredes Velázquez L, Dopico Vázquez D, Antón Aparicio LM: Choroid plexus carcinoma: a rare condition and its therapeutic management. Clin Transl Oncol; 2007 Jun;9(6):401-3
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  • [Title] Choroid plexus carcinoma: a rare condition and its therapeutic management.
  • Choroid plexus carcinomas are rare tumours, found chiefly during childhood.
  • We present the case of a patient with unusual metastatic dissemination, affecting lungs and bones two years after diagnosis, and the approach adopted towards him.
  • [MeSH-major] Carcinoma / therapy. Choroid Plexus Neoplasms / therapy

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  • (PMID = 17594955.001).
  • [ISSN] 1699-048X
  • [Journal-full-title] Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
  • [ISO-abbreviation] Clin Transl Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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87. Eng YY, Sharma VK, Ray AK: Ferrate(VI): green chemistry oxidant for degradation of cationic surfactant. Chemosphere; 2006 Jun;63(10):1785-90
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  • This paper demonstrates the unique property of ferrate(VI) to degrade almost completely the cationic surfactant, cetylpyridinium chloride (C(5)H(5)N(+)(CH(2))(15)CH(3).H(2)O Cl(-), CPC).
  • The Rate law for the oxidation of CPC by ferrate(VI) at pH 9.2 was found to be: -d[Fe(VI)]/dt = k[Fe(VI)][CPC](2).
  • Ferrate(VI) oxidizes CPC within minutes and molar consumption of ferrate(VI) was nearly equal to the oxidized CPC.
  • The decrease in total organic carbon (TOC) from CPC was more than 95%; suggesting mineralization of CPC to carbon dioxide.

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  • (PMID = 16303166.001).
  • [ISSN] 0045-6535
  • [Journal-full-title] Chemosphere
  • [ISO-abbreviation] Chemosphere
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Oxidants; 0 / Surface-Active Agents; 0 / Water Pollutants, Chemical; 16836-06-9 / ferrate ion; CUB7JI0JV3 / Cetylpyridinium; E1UOL152H7 / Iron
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88. Khashaba RM, Moussa MM, Mettenburg DJ, Rueggeberg FA, Chutkan NB, Borke JL: Polymeric-calcium phosphate cement composites-material properties: in vitro and in vivo investigations. Int J Biomater; 2010;2010
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  • New polymeric calcium phosphate cement composites (CPCs) were developed.
  • Cement powder consisting of 60 wt% tetracalcium phosphate, 30 wt% dicalcium phosphate dihydrate, and 10 wt% tricalcium phosphate was combined with either 35% w/w poly methyl vinyl ether maleic acid or polyacrylic acid to obtain CPC-1 and CPC-2.
  • The setting time and compressive and diametral tensile strength of the CPCs were evaluated and compared with that of a commercial hydroxyapatite cement.
  • In vitro cytotoxicity and in vivo biocompatibility of the two CPCs and hydroxyapatite cement were assessed.
  • CPC-1 and CPC-2 showed significantly higher compressive and diametral strength values compared to hydroxyapatite cement.
  • CPC-1 and CPC-2 were equivalent to Teflon controls after 1 week.
  • CPC-1, CPC-2, and hydroxyapatite cement elicited a moderate to intense inflammatory reaction at 7 days which decreased over time.
  • CPC-1 and CPC-2 show promise for orthopedic applications.

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  • (PMID = 20811498.001).
  • [ISSN] 1687-8795
  • [Journal-full-title] International journal of biomaterials
  • [ISO-abbreviation] Int J Biomater
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2927743
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89. Reichelt KV, Hartmann B, Weber B, Ley JP, Krammer GE, Engel KH: Identification of bisprenylated benzoic acid derivatives from yerba santa (Eriodictyon ssp.) using sensory-guided fractionation. J Agric Food Chem; 2010 Feb 10;58(3):1850-9
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  • [Title] Identification of bisprenylated benzoic acid derivatives from yerba santa (Eriodictyon ssp.) using sensory-guided fractionation.
  • Due to certain off-flavor problems and lacking bitter masking effects with Yerba Santa (Eriodictyon angustifolium and E. californicum) extracts, which are also described as bitter, herbal, medicinal, phenolic, or astringent, methanolic extracts were fractionated and evaluated for their taste properties using a high temperature liquid chromatography (HTLC)-based approach.
  • The taste-guided fractionation led to the identification of a series of novel bisprenylated benzoic acids (erionic acids A (1), B (2), C (3), D (4), E (5), and F (6) and eriolic acids A (7), B (8), C (9), and D (10), respectively), along with the known flavonoids eriodictyol, homoeriodictyol, hesperetin, and chrysoeriol.
  • The new compounds were isolated in larger amounts for characterization from Narrow Leaf Yerba Santa (E. angustifolium) and California Yerba Santa (E. californicum), respectively, using fast centrifugal partition chromatography (FCPC) and HTLC.
  • The structures were elucidated using one and two-dimensional NMR spectroscopy and high resolution mass spectrometry (HR-MS).
  • For E. californicum, data regarding seasonal and climatic variation of the eriolic acid contents and of the flavonoids were collected.
  • The flavor properties of some of the isolated new compounds were evaluated; they showed strong off-flavor characteristics, such as bitter, astringent, phenolic, or woody, and may contribute to the sensory effects observed for crude Yerba Santa extracts.
  • Erionic acid C (3) was not only able to increase the absolute bitterness but also to extinguish the bitter masking effect of homoeriodictyol in a caffeine solution.
  • [MeSH-major] Benzoic Acid / chemistry. Benzoic Acid / isolation & purification. Eriodictyon / chemistry. Plant Extracts / chemistry. Plant Extracts / isolation & purification. Taste
  • [MeSH-minor] Chemical Fractionation. Chromatography, Liquid. Humans. Molecular Structure

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  • [ErratumIn] J Agric Food Chem. 2010 Mar 24;58(6):3868
  • (PMID = 20058867.001).
  • [ISSN] 1520-5118
  • [Journal-full-title] Journal of agricultural and food chemistry
  • [ISO-abbreviation] J. Agric. Food Chem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Plant Extracts; 8SKN0B0MIM / Benzoic Acid
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90. Pizzo G, Guiglia R, Imburgia M, Pizzo I, D'Angelo M, Giuliana G: The effects of antimicrobial sprays and mouthrinses on supragingival plaque regrowth: a comparative study. J Periodontol; 2006 Feb;77(2):248-56
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  • The aim of this study was to investigate the plaque inhibitory effects of CHX, cetylpyridinium chloride (CPC), and triclosan (TRN) delivered by sprays and mouthrinses.
  • Products being tested (0.2% CHX, 0.12% CHX, 0.05% CPC, and 0.03% TRN) were used both as sprays and mouthrinses.
  • CPC spray did not differ from saline spray (P>0.05).
  • On the contrary, the TRN and CPC sprays showed little or no plaque inhibitory effects.

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  • (PMID = 16460251.001).
  • [ISSN] 0022-3492
  • [Journal-full-title] Journal of periodontology
  • [ISO-abbreviation] J. Periodontol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Aerosols; 0 / Anti-Infective Agents, Local; 0 / Coloring Agents; 0 / Mouthwashes; 451W47IQ8X / Sodium Chloride; 4NM5039Y5X / Triclosan; CUB7JI0JV3 / Cetylpyridinium; MOR84MUD8E / chlorhexidine gluconate; R4KO0DY52L / Chlorhexidine
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91. Meng D, Xie QF: [Animal implantation with a new type of chitosan microspheres/calcium phosphate cement]. Beijing Da Xue Xue Bao; 2009 Feb 18;41(1):80-5
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  • [Title] [Animal implantation with a new type of chitosan microspheres/calcium phosphate cement].
  • OBJECTIVE: To investigate bioactivity, biodegradation, bone conductive properties, and clinical maneuverability of a novel injectable chitosan microspheres/calcium phosphate cement (CPC).
  • METHODS: The bone defect of pi x 4 mmx4 mmx6 mm was made at both thigh bones of 12 rabbits, and experimental material (chitosan microspheres/CPC) or control material (alpha-tricalcium phosphate cement, alpha-TCP) was injected into the defect respectively.
  • Different size of cavities were observed in CPC after the degradation of chitosan microspheres.
  • The chitosan microspheres/CPC was dramatically degraded after 24 weeks with a few chitosan microspheres, and new bone replaced the degraded materials.
  • The implants with alpha-TCP were absorbed slowly compared with the chitosan microspheres/CPC.
  • Compared with the control material, adding chitosan microspheres into CPC could enhance its degradability and facilitate the new bone formation.

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  • (PMID = 19221571.001).
  • [ISSN] 1671-167X
  • [Journal-full-title] Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences
  • [ISO-abbreviation] Beijing Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biocompatible Materials; 0 / Bone Cements; 0 / Bone Substitutes; 0 / Calcium Phosphates; 0 / alpha-tricalcium phosphate; 9012-76-4 / Chitosan
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92. Seder DB, Fraser GL, Robbins T, Libby L, Riker RR: The bispectral index and suppression ratio are very early predictors of neurological outcome during therapeutic hypothermia after cardiac arrest. Intensive Care Med; 2010 Feb;36(2):281-8
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  • METHODS: Demographic data, BIS1, and SR1 were recorded from 97 patients after the first dose of neuromuscular blockade, with outcomes blinded, and compared to the discharge Cerebral Performance Category (CPC).
  • Receiver-operator characteristic curves and a multiple logistic regression model were constructed to predict good (CPC 1-2, GO) and poor (CPC 3-5, PO) neurological outcomes.
  • CONCLUSIONS: In our single-center cohort utilizing moderate sedation, the bispectral index and suppression ratio recorded after the first dose of intermittent neuromuscular blockade were accurate and very early predictors of neurological outcome during therapeutic hypothermia after cardiac arrest.
  • [MeSH-major] Coma / diagnosis. Coma / physiopathology. Heart Arrest / epidemiology. Heart Arrest / prevention & control. Hypothermia, Induced / methods

  • MedlinePlus Health Information. consumer health - Cardiac Arrest.
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  • [CommentIn] Intensive Care Med. 2011 Aug;37(8):1399; author reply 1400-1 [21688100.001]
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  • (PMID = 19847399.001).
  • [ISSN] 1432-1238
  • [Journal-full-title] Intensive care medicine
  • [ISO-abbreviation] Intensive Care Med
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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93. Riparbelli MG, Colozza G, Callaini G: Procentriole elongation and recruitment of pericentriolar material are downregulated in cyst cells as they enter quiescence. J Cell Sci; 2009 Oct 15;122(Pt 20):3613-8
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  • The apical region of the Drosophila testis contains a niche with two stem cell populations: germline stem cells (GSCs) and cyst progenitor cells (CPCs).
  • Although a considerable body of evidence indicates important roles for centrosomes in spindle orientation and asymmetrical division of GSCs, the behaviour and function of the centrioles in CPCs and their daughters remain unknown.

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  • (PMID = 19755490.001).
  • [ISSN] 1477-9137
  • [Journal-full-title] Journal of cell science
  • [ISO-abbreviation] J. Cell. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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94. Busche MN, Walsh MC, McMullen ME, Guikema BJ, Stahl GL: Mannose-binding lectin plays a critical role in myocardial ischaemia and reperfusion injury in a mouse model of diabetes. Diabetologia; 2008 Aug;51(8):1544-51
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  • AIMS/HYPOTHESIS: Diabetic patients are at increased risk of cardiomyopathy, acute myocardial infarction and loss of cardiac progenitor cells (CPCs), but the aetiology is poorly understood.
  • METHODS: The role of MBL in myocardial ischaemia and reperfusion (MI/R) injury was investigated in wild-type (WT) and MBL-null mice following 2 weeks of streptozotocin-induced hyperglycaemia.
  • Immunohistochemical analysis of CPCs showed significantly lower numbers in diabetic WT hearts compared with non-diabetic hearts.
  • Insulin-treated diabetic WT or untreated diabetic MBL-null mice were protected from dilative cardiomyopathy, hypertrophic remodelling and loss of CPCs.
  • Further, the absence of MBL appears to inhibit hypertrophic remodelling and hyperglycaemia-induced loss of CPCs after just 2 weeks of hyperglycaemia in mice.
  • [MeSH-minor] Animals. Complement System Proteins / physiology. Crosses, Genetic. Diabetes Mellitus, Type 1 / complications. Diabetes Mellitus, Type 1 / physiopathology. Diabetic Angiopathies / physiopathology. Disease Models, Animal. Female. Male. Mice. Mice, Inbred C57BL. Mice, Knockout. Neutrophils / physiology

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  • (PMID = 18493734.001).
  • [ISSN] 0012-186X
  • [Journal-full-title] Diabetologia
  • [ISO-abbreviation] Diabetologia
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / R01 HL052886; United States / NHLBI NIH HHS / HL / R01 HL052886-13; United States / NIDCR NIH HHS / DE / DE016191; United States / NHLBI NIH HHS / HL / HL52886; United States / NHLBI NIH HHS / HL / HL79758; United States / NHLBI NIH HHS / HL / HL56068; United States / NIDCR NIH HHS / DE / DE017821
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Mannose-Binding Lectin; 9007-36-7 / Complement System Proteins
  • [Other-IDs] NLM/ NIHMS66299; NLM/ PMC2542900
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95. Warf B, Ondoma S, Kulkarni A, Donnelly R, Ampeire M, Akona J, Kabachelor CR, Mulondo R, Nsubuga BK: Neurocognitive outcome and ventricular volume in children with myelomeningocele treated for hydrocephalus in Uganda. J Neurosurg Pediatr; 2009 Dec;4(6):564-70
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  • OBJECT: Despite lower failure and infection rates compared with shunt placement, it has not been known whether endoscopic third ventriculostomy/choroid plexus cauterization (ETV/CPC) might be inferior in regard to neurocognitive development.
  • This study is the first to describe neurocognitive outcome and ventricle volume in infants with hydrocephalus due to myelomeningocele that was treated primarily by ETV/CPC.
  • Fifty-five of these children had been treated by ETV/CPC, 19 received ventriculoperitoneal (VP) shunts, and 19 had required no treatment for hydrocephalus.
  • The mean scale scores for untreated patients were no different from normal (all p > 0.27) in all portions of the BSID (excluding gross motor), and were generally significantly better than those for both VP shunt-treated and ETV/CPC groups.
  • The ETV/ CPC-treated patients had nonsignificantly better mean scores than patients treated with VP shunts in all portions of the BSID (all p > 0.06), except receptive communication, which was significantly better for the ETV/CPC group (p = 0.02).
  • The mean FOR was similar among groups, with no significant difference between the untreated group and either the VP shunt or ETV/CPC groups.
  • CONCLUSIONS: The ETV/CPC and VP shunt groups had similar neurocognitive outcomes.
  • [MeSH-major] Choroid Plexus / surgery. Cognition. Developing Countries. Endoscopy. Hydrocephalus / psychology. Hydrocephalus / surgery. Meningomyelocele / complications. Nervous System / physiopathology


96. Sun XH, Lu YY, Chen SG, Li LJ, Shen XY: [Sorption and mechanism of surfactants on bentonite in combined pollution]. Huan Jing Ke Xue; 2007 Apr;28(4):838-42
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  • Sorption of cationic surfactant cetyl pyridinium chloride (CPC), anionic surfactant sodium dodecylbenzene sulfonate (SDBS) and nonionic surfactant Triton X-100 (TX-100) on bentonite was studied.
  • The influences of cation-exchange capacity (CEC), temperature and salinity on the sorption of CPC were also discussed.
  • The results indicate that the sorption of CPC on Na-bentonite is greater than that of TX-100 and SDBS, and SDBS hardly shows any sorption.
  • CPC is adsorbed to Na-bentonite through a combination of hydrophobic bonding and cation-exchange.
  • The amount of CPC adsorbed on bentonite decreases with increasing temperature, and increases with increasing CEC.
  • NaCl can enhance the sorption of CPC on bentonite.

  • Hazardous Substances Data Bank. BENTONITE .
  • Hazardous Substances Data Bank. SODIUM DODECYLBENZENESULFONATE .
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  • (PMID = 17639947.001).
  • [ISSN] 0250-3301
  • [Journal-full-title] Huan jing ke xue= Huanjing kexue
  • [ISO-abbreviation] Huan Jing Ke Xue
  • [Language] CHI
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Benzenesulfonates; 0 / Soil Pollutants; 0 / Surface-Active Agents; 1302-78-9 / Bentonite; 60NSK897G9 / dodecylbenzenesulfonic acid; 9002-93-1 / Octoxynol; CUB7JI0JV3 / Cetylpyridinium
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97. Ziegler A, Seelig J: Binding and clustering of glycosaminoglycans: a common property of mono- and multivalent cell-penetrating compounds. Biophys J; 2008 Mar 15;94(6):2142-9
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  • Recent observations in cell culture provide evidence that negatively charged glycosaminoglycans (GAGs) at the surface of biological cells bind cationic cell-penetrating compounds (CPCs) and cluster during CPC binding, thereby contributing to their endocytotic uptake.
  • The GAG binding and clustering occur in the low-micromolar concentration range and suggest a tight interaction between GAGs and CPCs, although the relation between binding affinity and specificity of this interaction remains to be investigated.
  • We therefore measured the GAG binding and clustering of various mono- and multivalent CPCs such as DNA transfection vectors (polyethylenimine; 1,2-dioleoyl-3-trimethylammonium-propane), amino acid homopolymers (oligoarginine; oligolysine), and cell-penetrating peptides (Penetratin; HIV-1 Tat) by means of isothermal titration calorimetry and dynamic light scattering.
  • We find that these structurally diverse CPCs share the property of GAG binding and clustering.
  • The hydrodynamic radius of the resulting aggregates ranges from 78 nm to 586 nm, suggesting that they consist of numerous GAG chains cross-linked by CPCs.
  • Because the binding and clustering of GAGs were found to be a common denominator of all CPCs tested, these properties might be helpful to identify further CPCs.

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  • (PMID = 18065465.001).
  • [ISSN] 1542-0086
  • [Journal-full-title] Biophysical journal
  • [ISO-abbreviation] Biophys. J.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carrier Proteins; 0 / Cations; 0 / Glycosaminoglycans; 0 / Peptides; 0 / penetratin; 059QF0KO0R / Water; 9002-98-6 / Polyethyleneimine; F30N4O6XVV / Acridine Orange; K3Z4F929H6 / Lysine
  • [Other-IDs] NLM/ PMC2257919
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98. Bangale A, Kalbfleisch K: A traveler caught in the "thick" of things: A CPC case of a young African American female with headaches. Acad Emerg Med; 2010 Nov;17(11):e141-8
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  • [Title] A traveler caught in the "thick" of things: A CPC case of a young African American female with headaches.
  • [MeSH-major] Headache / parasitology. Malaria, Cerebral / complications. Malaria, Cerebral / diagnosis. Travel
  • [MeSH-minor] Adult. African Americans. Diagnosis, Differential. Female. Fever / complications. Humans. Malaria, Falciparum. Plasmodium falciparum / isolation & purification. Sierra Leone

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  • (PMID = 21175507.001).
  • [ISSN] 1553-2712
  • [Journal-full-title] Academic emergency medicine : official journal of the Society for Academic Emergency Medicine
  • [ISO-abbreviation] Acad Emerg Med
  • [Language] eng
  • [Publication-type] Case Reports; Clinical Conference; Journal Article
  • [Publication-country] United States
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99. Cottage CT, Bailey B, Fischer KM, Avitabile D, Collins B, Tuck S, Quijada P, Gude N, Alvarez R, Muraski J, Sussman MA: Cardiac progenitor cell cycling stimulated by pim-1 kinase. Circ Res; 2010 Mar 19;106(5):891-901
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  • OBJECTIVE: Effects of cardiac-specific Pim-1 kinase expression on the cardiac progenitor cell (CPC) population were examined to determine whether Pim-1 mediates beneficial effects through augmenting CPC activity.
  • METHODS AND RESULTS: Transgenic mice created with cardiac-specific Pim-1 overexpression (Pim-wt) exhibit enhanced Pim-1 expression in both cardiomyocytes and CPCs, both of which show increased proliferative activity assessed using 5-bromodeoxyuridine (BrdU), Ki-67, and c-Myc relative to nontransgenic controls.
  • However, the total number of CPCs was not increased in the Pim-wt hearts during normal postnatal growth or after infarction challenge.
  • These results suggest that Pim-1 overexpression leads to asymmetric division resulting in maintenance of the CPC population.
  • Localization and quantitation of cell fate determinants Numb and alpha-adaptin by confocal microscopy were used to assess frequency of asymmetric division in the CPC population.
  • Polarization of Numb in mitotic phospho-histone positive cells demonstrates asymmetric division in 65% of the CPC population in hearts of Pim-wt mice versus 26% in nontransgenic hearts after infarction challenge.
  • Similarly, Pim-wt hearts had fewer cells with uniform alpha-adaptin staining indicative of symmetrically dividing CPCs, with 36% of the CPCs versus 73% in nontransgenic sections.

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  • (PMID = 20075333.001).
  • [ISSN] 1524-4571
  • [Journal-full-title] Circulation research
  • [ISO-abbreviation] Circ. Res.
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / RC1 HL100891-01; United States / NHLBI NIH HHS / HL / HL091102-02; United States / NHLBI NIH HHS / HL / HL085577-01; United States / NHLBI NIH HHS / HL / HL067245-08; United States / NHLBI NIH HHS / HL / P01 HL085577-01; United States / NHLBI NIH HHS / HL / RC1 HL100891; United States / NHLBI NIH HHS / HL / R37 HL091102-01; None / None / / R37 HL091102-02S1; None / None / / RC1 HL100891-01; United States / NHLBI NIH HHS / HL / R01HL067245; United States / NHLBI NIH HHS / HL / HL091102-01; United States / NHLBI NIH HHS / HL / 1R37 HL091102; United States / NHLBI NIH HHS / HL / HL085577-02; United States / NHLBI NIH HHS / HL / HL067245-07; United States / NHLBI NIH HHS / HL / HL091102-03; United States / NHLBI NIH HHS / HL / R37 HL091102-02S1; United States / NHLBI NIH HHS / HL / R37 HL091102-02; United States / NHLBI NIH HHS / HL / R37 HL091102; United States / NHLBI NIH HHS / HL / P01 HL085577-02; United States / NIA NIH HHS / AG / 7P01 AG023071; United States / NHLBI NIH HHS / HL / R37 HL091102-03; United States / NHLBI NIH HHS / HL / R01 HL067245-06; United States / NHLBI NIH HHS / HL / HL091102-04; United States / NHLBI NIH HHS / HL / R01 HL067245; United States / NHLBI NIH HHS / HL / P01 HL085577; United States / NHLBI NIH HHS / HL / R01 HL067245-07; United States / NIA NIH HHS / AG / P01 AG023071; United States / NHLBI NIH HHS / HL / HL067245-06; United States / NHLBI NIH HHS / HL / R37 HL091102-04; United States / NHLBI NIH HHS / HL / R01 HL067245-08
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Protein Complex alpha Subunits; 0 / Histones; 0 / Membrane Proteins; 0 / Nerve Tissue Proteins; 0 / Numb protein, mouse; EC 2.7.11.1 / PIM1 protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins c-pim-1
  • [Other-IDs] NLM/ NIHMS290856; NLM/ PMC3116713
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100. Slattery SD, Moore RV, Brinkley BR, Hall RM: Aurora-C and Aurora-B share phosphorylation and regulation of CENP-A and Borealin during mitosis. Cell Cycle; 2008 Mar 15;7(6):787-95
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  • We have found that Aurora-C interacts with Borealin in addition to the other known members of the Aurora-B chromosomal passenger complex (CPC).
  • These molecular mechanisms are consistent with our observation that in the absence of Aurora-B, Aurora-C is sufficient for proper mitotic phosphorylation of CENP-A and centromeric localization of the CPC proteins.

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  • (PMID = 18239465.001).
  • [ISSN] 1551-4005
  • [Journal-full-title] Cell cycle (Georgetown, Tex.)
  • [ISO-abbreviation] Cell Cycle
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA041424; United States / NCI NIH HHS / CA / CA 41424
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Autoantigens; 0 / CDCA8 protein, human; 0 / Cell Cycle Proteins; 0 / Chromosomal Proteins, Non-Histone; 0 / centromere protein A; EC 2.7.11.1 / AURKB protein, human; EC 2.7.11.1 / AURKC protein, human; EC 2.7.11.1 / Aurora Kinase B; EC 2.7.11.1 / Aurora Kinase C; EC 2.7.11.1 / Aurora Kinases; EC 2.7.11.1 / Protein-Serine-Threonine Kinases
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