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1. Song HH, Baik GH, Kwon JH, Lee KS, Choi YH, Choi KC, Park YE: A case of primary gastric CD30-positive anaplastic large-cell lymphoma. J Korean Med Sci; 2005 Dec;20(6):1062-5
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  • [Title] A case of primary gastric CD30-positive anaplastic large-cell lymphoma.
  • Gastric CD30-positive anaplastic large-cell lymphoma is a very rare disease.
  • It is sometimes difficult to distinguish it from undifferentiated carcinoma, sarcoma and so on.
  • We report here on a case of primary gastric anaplastic large-cell lymphoma.
  • The gross finding of the resected stomach was an 8 x 4.5 cm sized ulceroinfiltrative lesion at the pyloric antrum along the lesser curvature.
  • Immunohistochemically, the tumor cells were positive for CD30, vimentin and CD3, and this was a finding compatible with anaplastic large-cell lymphoma.
  • [MeSH-major] Antigens, CD30 / metabolism. Lymphoma, Large B-Cell, Diffuse / immunology. Lymphoma, Large B-Cell, Diffuse / pathology. Stomach Neoplasms / immunology. Stomach Neoplasms / pathology

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  • (PMID = 16361823.001).
  • [ISSN] 1011-8934
  • [Journal-full-title] Journal of Korean medical science
  • [ISO-abbreviation] J. Korean Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Antigens, CD30; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / Receptor Protein-Tyrosine Kinases; EC 2.7.10.1 / anaplastic lymphoma kinase
  • [Other-IDs] NLM/ PMC2779310
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2. Hakamada K, Miura T, Kimura A, Nara M, Toyoki Y, Narumi S, Sasak M: Anaplastic carcinoma associated with a mucinous cystic neoplasm of the pancreas during pregnancy: report of a case and a review of the literature. World J Gastroenterol; 2008 Jan 7;14(1):132-5
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  • [Title] Anaplastic carcinoma associated with a mucinous cystic neoplasm of the pancreas during pregnancy: report of a case and a review of the literature.
  • Oncogenesis of anaplastic carcinoma of the pancreas is a subject of controversy, because it shows sarcomatous nature with extremely poor prognosis.
  • We herein report an unusual case of anaplastic carcinoma occurring with a recurrent mucinous cystic neoplasm in a 38-year-old female.
  • A 10-cm retroperitoneal cystic mass was pointed out in the first pregnancy and a probable diagnosis of mucinous cystic neoplasm was made in October 2000.
  • During her second pregnancy in 2002, however, she presented hematemesis and underwent urgent distal pancreatectomy, splenectomy and partial resection of the gastric wall where the tumor perforated.
  • A diagnosis of borderline-type mucinous cystic neoplasm with ovarian-like stroma was made.
  • Pathology revealed that the tumor was composed of two different components of borderline-type mucinous cystic neoplasm and anaplastic carcinoma.
  • Although the origin of anaplastic carcinoma has not been determined yet, it should be remembered that anaplastic carcinoma can occur in association with mucinous cystic neoplasm of more benign histology.
  • [MeSH-major] Carcinoma / pathology. Neoplasms, Cystic, Mucinous, and Serous / pathology. Pancreatic Neoplasms / pathology. Pregnancy Complications, Neoplastic / pathology

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  • (PMID = 18176976.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 14
  • [Other-IDs] NLM/ PMC2673378
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3. García-Rostán G, Costa AM, Pereira-Castro I, Salvatore G, Hernandez R, Hermsem MJ, Herrero A, Fusco A, Cameselle-Teijeiro J, Santoro M: Mutation of the PIK3CA gene in anaplastic thyroid cancer. Cancer Res; 2005 Nov 15;65(22):10199-207
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  • [Title] Mutation of the PIK3CA gene in anaplastic thyroid cancer.
  • Recently, it has been reported that somatic mutations within the PI3K catalytic subunit, PIK3CA, are common (25-40%) among colorectal, gastric, breast, ovarian cancers, and high-grade brain tumors.
  • In this study, 13 thyroid cancer cell lines, 80 well-differentiated thyroid carcinomas of follicular (WDFC) and papillary (WDPC) type, and 70 anaplastic thyroid carcinomas (ATC) were investigated, by PCR-direct sequencing, for activating PIK3CA mutations at exons 9 and 20.
  • In 18 of the 20 ATC cases showing coexisting differentiated carcinoma, mutations, when present, were restricted to the ATC component and located primarily within the kinase domain.
  • [MeSH-major] Carcinoma / genetics. Mutation, Missense. Phosphatidylinositol 3-Kinases / genetics. Thyroid Neoplasms / genetics
  • [MeSH-minor] Adenocarcinoma, Follicular / enzymology. Adenocarcinoma, Follicular / genetics. Adenocarcinoma, Follicular / pathology. Amino Acid Substitution. Carcinoma, Papillary / enzymology. Carcinoma, Papillary / genetics. Carcinoma, Papillary / pathology. Cell Growth Processes / genetics. Cell Line, Tumor. Enzyme Activation. Genes, p53 / genetics. Genes, ras / genetics. Humans. Oncogene Protein v-akt / metabolism. Proto-Oncogene Proteins B-raf / genetics


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4. Falzarano SM, Mourmouras V, Mastrogiulio MG, La Magra C, Vindigni C: Undifferentiated gastric carcinoma with lymphoid stroma (lymphoepithelioma-like carcinoma/medullary carcinoma). Pathologica; 2009 Feb;101(1):15-7
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  • [Title] Undifferentiated gastric carcinoma with lymphoid stroma (lymphoepithelioma-like carcinoma/medullary carcinoma).
  • Undifferentiated gastric carcinoma with lymphoid stroma is a histological type of gastric cancer with favourable prognosis, microscopically characterised by nests of neoplastic epithelial cells intermingled with a dense lymphoid proliferation.
  • Various studies have shown a close relationship between undifferentiated gastric carcinoma with lymphoid stroma and Epstein-Barr virus infection; the presence of viral DNA in tumour cell nuclei has been demonstrated using polymerase chain reaction and Epstein-Barr virus-encoded small RNA in neoplastic cell nuclei have been found using in situ hybridization.
  • We describe two cases of undifferentiated gastric carcinoma with lymphoid stroma, one infiltrating the submucosa of the gastric body and the other invading the muscularis propria of the antrum.
  • [MeSH-major] Carcinoma, Medullary / pathology. Cell Differentiation. Lymphoid Tissue / pathology. Stomach Neoplasms / pathology
  • [MeSH-minor] Aged. Cell Nucleus / metabolism. Cell Proliferation. DNA, Viral / metabolism. Epstein-Barr Virus Infections / diagnosis. Epstein-Barr Virus Infections / pathology. Epstein-Barr Virus Infections / virology. Female. Herpesvirus 4, Human / genetics. Humans. Male. Middle Aged. Prognosis

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  • (PMID = 19771767.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / DNA, Viral
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5. Aihara R, Mochiki E, Nakabayashi T, Akazawa K, Asao T, Kuwano H: Clinical significance of mucin phenotype, beta-catenin and matrix metalloproteinase 7 in early undifferentiated gastric carcinoma. Br J Surg; 2005 Apr;92(4):454-62
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  • [Title] Clinical significance of mucin phenotype, beta-catenin and matrix metalloproteinase 7 in early undifferentiated gastric carcinoma.
  • BACKGROUND: The aim of this study was to examine the clinical significance of mucin phenotypes of early undifferentiated gastric carcinoma, and to identify variables that might be used to select patients suitable for minimally invasive surgery.
  • METHODS: A total of 129 patients with early undifferentiated gastric carcinoma were studied.
  • Tumours were classified into gastric (G), intestinal, gastrointestinal (GI) or unclassified type.
  • Undifferentiated carcinomas were classified into signet-ring cell carcinoma (SIG) and non-SIG.
  • CONCLUSION: GI-type early undifferentiated carcinomas and those with non-SIG histology had increased potential for invasion and metastasis.
  • [MeSH-major] Cytoskeletal Proteins / metabolism. Matrix Metalloproteinase 7 / metabolism. Mucins / metabolism. Stomach Neoplasms / metabolism. Trans-Activators / metabolism

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  • (PMID = 15609380.001).
  • [ISSN] 0007-1323
  • [Journal-full-title] The British journal of surgery
  • [ISO-abbreviation] Br J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CTNNB1 protein, human; 0 / Cytoskeletal Proteins; 0 / Mucins; 0 / Trans-Activators; 0 / beta Catenin; EC 3.4.24.23 / Matrix Metalloproteinase 7
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6. Kościuch J, Zielonka TM, Ziółkowski B, Domagała-Kulawik J, Bogacka-Zatorska E, Chazan R: [Breast carcinoma and anaplastic gastric carcinoma with pleural metastases in patient after mastectomy 30 years ago]. Pneumonol Alergol Pol; 2006;74(1):129-31
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  • [Title] [Breast carcinoma and anaplastic gastric carcinoma with pleural metastases in patient after mastectomy 30 years ago].
  • We describe a case of two simultaneous malignancies--anaplastic gastric carcinoma with pleural metastases and left breast carcinoma.
  • Her parents died from malignancies--mother from gastric cancer and father from pulmonary carcinoma.
  • [MeSH-major] Breast Neoplasms / pathology. Carcinoma / pathology. Carcinoma / secondary. Neoplasms, Multiple Primary / pathology. Pleural Neoplasms / secondary. Stomach Neoplasms / pathology

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  • (PMID = 17175993.001).
  • [ISSN] 0867-7077
  • [Journal-full-title] Pneumonologia i alergologia polska
  • [ISO-abbreviation] Pneumonol Alergol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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7. Lazăr D, Tăban S, Raica M, Sporea I, Cornianu M, Goldiş A, Vernic C: Immunohistochemical evaluation of the tumor neoangiogenesis as a prognostic factor for gastric cancers. Rom J Morphol Embryol; 2008;49(2):137-48
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  • [Title] Immunohistochemical evaluation of the tumor neoangiogenesis as a prognostic factor for gastric cancers.
  • MATERIAL AND METHODS: We evaluated the relation between MVD, the VEGF expression, the clinicopathologic factors and the survival in patients with gastric cancer.
  • A prospective study has been carried out, regarding the evolution and aggressiveness of the gastric cancer, with a duration of 5 years, 61 patients that underwent a surgery for gastric cancer being included in the study.
  • The immunohistochemical reactions for CD34 and VEGF were performed for all gastric cancers cases included in the study group.
  • RESULTS: MVD has shown in the gastric carcinomas an average value significantly higher in comparison to the normal mucosa (38.7 vs. 12.5, p<0.001 ES).
  • In the intestinal type we have noticed a much lower average MVD than the average MVD in the diffuse type of gastric carcinomas (36.8 vs. 41.6) (p=0.02478 S).
  • The anaplastic carcinoma and the signet ring cell carcinoma are detaching themselves as histological forms associated to an intense neoangiogenesis activity.
  • The positive immunoreactions for VEGF are significantly more frequent in the gastric carcinomas, in comparison to the normal gastric mucosa (65.6% vs. 6.5%, p<0.001 ES).
  • CONCLUSIONS: Our results prove the major correlation between the VEGF expression and the 5-year survival rate of the patients with gastric cancer, the survival rate for the carcinomas with VEGF +~++ being significantly lower than for the VEGF negative ones (12.5% vs. 23.8%) (p=0.027983 S).
  • [MeSH-major] Adenocarcinoma / diagnosis. Neovascularization, Pathologic / diagnosis. Stomach Neoplasms / diagnosis

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  • (PMID = 18516318.001).
  • [ISSN] 1220-0522
  • [Journal-full-title] Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
  • [ISO-abbreviation] Rom J Morphol Embryol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / Antibodies; 0 / Antigens, CD34; 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A
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8. Lazăr D, Tăban S, Ardeleanu C, Dema A, Sporea I, Cornianu M, Lazăr E, Vernic C: The immunohistochemical expression of E-cadherin in gastric cancer; correlations with clinicopathological factors and patients' survival. Rom J Morphol Embryol; 2008;49(4):459-67
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  • [Title] The immunohistochemical expression of E-cadherin in gastric cancer; correlations with clinicopathological factors and patients' survival.
  • BACKGROUND: The aim of our study is to investigate the immunohistochemical expression of E-cadherin in gastric carcinomas and in surrounding mucosa (normal or with lesions of chronic atrophic gastritis, intestinal metaplasia or dysplasia).
  • MATERIAL AND METHODS: We included 61 patients with gastric cancers operated in Emergency County Hospital Timisoara.
  • Aberrant E-cadherin expression was noticed in 30 cases of gastric carcinomas (49.2%) and in 11 cases (35.5%) of epithelial dysplasia in the surrounding tissue.
  • Signet-ring carcinomas and anaplastic carcinomas presented a high-proportion of aberrant immunostainings (82.4% and 100%), as well as poor differentiated carcinomas (61.5%).
  • CONCLUSIONS: In gastric carcinomas and areas of epithelial dysplasia, aberrant E-cadherin expression was significantly more frequent in comparison with the surrounding normal mucosa (p<0.001 ES).
  • Our data suggest a strong correlation between Lauren's classification of gastric carcinomas and E-cadherin immunohistochemical expression.
  • [MeSH-major] Cadherins / metabolism. Carcinoma / mortality. Stomach Neoplasms / mortality

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  • (PMID = 19050793.001).
  • [ISSN] 1220-0522
  • [Journal-full-title] Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
  • [ISO-abbreviation] Rom J Morphol Embryol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / Cadherins
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9. Aihara R, Mochiki E, Kamiyama Y, Ohno T, Asao T, Kuwano H: Matrilsin expression is a useful marker of submucosal invasion and lymph node metastasis in early stage signet ring cell carcinoma of the stomach. J Surg Oncol; 2006 May 1;93(6):491-7
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  • [Title] Matrilsin expression is a useful marker of submucosal invasion and lymph node metastasis in early stage signet ring cell carcinoma of the stomach.
  • The aim of this study was to examine the MMP-7 expression of early-stage undifferentiated gastric carcinoma, and to investigate differences between gastric signet ring cell (SIG) and other undifferentiated carcinomas (non-SIG).
  • METHODS: Immunohistochemical staining of MMP-7 was performed using specimens from 150 patients with early-stage gastric undifferentiated carcinomas (76 SIG, 74 non-SIG).
  • RESULTS: SIG had a larger proportion of mucosal-confined carcinoma and a lower rate of lymphatic invasion than non-SIG (P < 0.05).
  • [MeSH-major] Biomarkers, Tumor / biosynthesis. Carcinoma, Signet Ring Cell / metabolism. Gastric Mucosa / pathology. Lymph Nodes / pathology. Matrix Metalloproteinase 7 / biosynthesis. Stomach Neoplasms / metabolism
  • [MeSH-minor] Adult. Carcinoma / metabolism. Carcinoma / pathology. Carcinoma / surgery. Female. Humans. Immunohistochemistry. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging

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  • [Copyright] Copyright 2006 Wiley-Liss, Inc.
  • (PMID = 16615152.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 3.4.24.23 / Matrix Metalloproteinase 7
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10. Hiramatsu K, Mizukami Y, Momiyama M, Suzuki M, Niimi K, Nagashima T: [Stage IV gastric cancer patient who underwent palliative gastrectomy showing complete response to induction therapy with methotrexate plus 5-fluorouracil and secondary treatment with oral TS-1]. Gan To Kagaku Ryoho; 2005 Aug;32(8):1163-6
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  • [Title] [Stage IV gastric cancer patient who underwent palliative gastrectomy showing complete response to induction therapy with methotrexate plus 5-fluorouracil and secondary treatment with oral TS-1].
  • We describe our experience with a patient who had undifferentiated gastric carcinoma with extensive lymph node metastasis, including para-aortic lymph-node metastasis, and had a complete response to induction therapy with methotrexate plus 5-fluorouracil (sequential therapy with MTX, 5-FU, and Leucovorin) and secondary treatment with oral TS-1.
  • The patient was a 71-year-old woman with a massive gastric tumor (signet ring cell carcinoma), occupying most of the stomach.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Signet Ring Cell / drug therapy. Gastrectomy. Oxonic Acid / administration & dosage. Palliative Care. Pyridines / administration & dosage. Stomach Neoplasms / drug therapy. Tegafur / administration & dosage

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  • (PMID = 16121921.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / CA-19-9 Antigen; 0 / Carcinoembryonic Antigen; 0 / Drug Combinations; 0 / Pyridines; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; YL5FZ2Y5U1 / Methotrexate
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11. Tanner M, Hollmén M, Junttila TT, Kapanen AI, Tommola S, Soini Y, Helin H, Salo J, Joensuu H, Sihvo E, Elenius K, Isola J: Amplification of HER-2 in gastric carcinoma: association with Topoisomerase IIalpha gene amplification, intestinal type, poor prognosis and sensitivity to trastuzumab. Ann Oncol; 2005 Feb;16(2):273-8
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  • [Title] Amplification of HER-2 in gastric carcinoma: association with Topoisomerase IIalpha gene amplification, intestinal type, poor prognosis and sensitivity to trastuzumab.
  • We wanted to investigate the frequency and clinical significance of HER-2/neu amplification in gastric carcinoma.
  • PATIENTS AND METHODS: The frequency of HER-2/neu and Topoisomerase IIalpha gene amplification was studied in adenocarcinomas of the stomach (n=131) and the gastroesophageal junction (n=100) by chromogenic in situ hybridization (CISH).
  • Sensitivity of a gastric cancer cell line N87 with HER-2/neu amplification to trastuzumab was studied by a cell viability assay and compared with that of a HER-2 amplified breast cancer cell line SKBR-3.
  • RESULTS: HER-2/neu amplification was present in 16 (12.2%) of the 131 gastric and in 24 (24.0%) of the 100 gastroesophageal adenocarcinomas.
  • Co-amplification of Topoisomerase IIalpha was present in the majority of gastric (63%) and esophagogastric junction cancers (68%) with HER-2/neu amplification.
  • HER-2/neu amplification was more common in the intestinal histologic type of gastric cancer (21.5%) than in the diffuse (2%) or the mixed/anaplastic type (5%, P=0.0051), but it was not associated with gender, age at diagnosis or clinical stage.
  • Presence of HER-2/neu amplification was associated with poor carcinoma-specific survival (P=0.0089).
  • HER-2/neu targeting antibody trastuzumab inhibited the growth of a p185(HER-2/neu) overexpressing gastric and breast carcinoma cell lines (N87 and SKBR-3) with equal efficacy.
  • CONCLUSIONS: HER-2/neu amplification is common in the intestinal type of gastric carcinoma, and it is associated with a poor outcome.

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  • (PMID = 15668283.001).
  • [ISSN] 0923-7534
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / DNA-Binding Proteins; 0 / Isoenzymes; EC 5.99.1.3 / DNA Topoisomerases, Type II; EC 5.99.1.3 / DNA topoisomerase II alpha
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12. Lazăr D, Tăban S, Sporea I, Dema A, Cornianu M, Lazăr E, Goldiş A, Vernic C: Gastric cancer: correlation between clinicopathological factors and survival of patients. II. Rom J Morphol Embryol; 2009;50(2):185-94
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  • [Title] Gastric cancer: correlation between clinicopathological factors and survival of patients. II.
  • PURPOSE: The purpose of this study was to identify the clinicopathological factors that influence the prognosis of patients having undergone surgery for gastric cancer.
  • MATERIAL AND METHODS: From the total number of 265 patients (186 men and 79 women) diagnosed with gastric cancer in the period 1998-2002, 61 operated patients were selected.
  • On this group, we performed a prospective study regarding the evolution and aggressiveness of gastric cancer, on a duration of 5 years.
  • We have identified five papillary adenocarcinomas (8.2%), 28 tubular adenocarcinomas (46%), 17 "signet-ring" cell carcinomas (27.8%), eight mucinous adenocarcinomas (13.1%), and three undifferentiated or anaplastic carcinomas.
  • Most gastric carcinomas examined were included in the category of poorly differentiated carcinomas (63.9%).
  • According to the Lauren's classification, we have identified 38 intestinal type gastric carcinomas (62.3%), 17 diffuse type carcinomas (27.9%), and six mixed carcinomas (9.8%).
  • CONCLUSIONS: "Signet-ring" cells carcinomas, and the anaplastic ones, prove in our study to be extremely aggressive histological forms, characterized through low rates of survival.
  • [MeSH-major] Carcinoma / pathology. Stomach Neoplasms / pathology

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  • (PMID = 19434309.001).
  • [ISSN] 1220-0522
  • [Journal-full-title] Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
  • [ISO-abbreviation] Rom J Morphol Embryol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
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13. Lazăr D, Tăban S, Sporea I, Dema A, Cornianu M, Lazăr E, Goldiş A, Vernic C: Ki-67 expression in gastric cancer. Results from a prospective study with long-term follow-up. Rom J Morphol Embryol; 2010;51(4):655-61
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  • [Title] Ki-67 expression in gastric cancer. Results from a prospective study with long-term follow-up.
  • AIM: The analysis of immunohistochemical expression of the Ki-67 antigen using the monoclonal antibody MIB1 in 61 patients with gastric cancer, the correlation with clinicopathological factors and the prognosis of the patients.
  • RESULTS: In the gastric carcinomas, we remarked various Ki-67 scores.
  • For a proper grouping of the results, we classified gastric carcinomas into two categories: carcinomas with high MI Ki-67 (≥45%) and carcinomas with low MI Ki-67 (≤45%).
  • We noticed an increased frequency of high MI Ki-67 carcinomas in elderly patients (p=0.03) and also in the tumors developed at cardia level and those extended in the entire stomach in the moment of diagnosis (p<0.001).
  • The histological forms associated to high Ki-67 values are represented by the anaplastic carcinoma (100% of cases) and papillary adenocarcinoma (60% of cases).We observed a close correlation between the degree of tumor differentiation and the Ki-67 score (p<0.001).
  • The results of our study do not reveal any correlation between the Lauren's Classification of gastric carcinomas, the lymphovascular invasion, the depth of tumor invasion, the TNM stage and the Ki-67 score (p>0.05).
  • [MeSH-major] Ki-67 Antigen / metabolism. Stomach Neoplasms / immunology

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  • (PMID = 21103622.001).
  • [ISSN] 1220-0522
  • [Journal-full-title] Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
  • [ISO-abbreviation] Rom J Morphol Embryol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / Ki-67 Antigen
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14. Fujiyoshi Y, Eimoto T: Chromogranin A expression correlates with tumour cell type and prognosis in signet ring cell carcinoma of the stomach. Histopathology; 2008 Feb;52(3):305-13
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  • [Title] Chromogranin A expression correlates with tumour cell type and prognosis in signet ring cell carcinoma of the stomach.
  • AIMS: To investigate neuroendocrine (NE) differentiation in gastric signet ring cell carcinoma (SRCC) using chromogranin A (CgA) as an indicator of a well-differentiated NE phenotype and to determine its relationship to cell type, stage and prognosis.
  • Small cell and anaplastic-type SRCC cells were only rarely immunopositive.
  • CONCLUSION: CgA expression is restricted to certain tumour cell types and may help to predict prognosis in gastric SRCCs.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Carcinoma, Signet Ring Cell / pathology. Chromogranin A / metabolism. Stomach Neoplasms / pathology


15. Honda T, Tamura G, Endoh Y, Nishizuka S, Kawata S, Motoyama T: Expression of tumor suppressor and tumor-related proteins in differentiated carcinoma, undifferentiated carcinoma with tubular component and pure undifferentiated carcinoma of the stomach. Jpn J Clin Oncol; 2005 Oct;35(10):580-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of tumor suppressor and tumor-related proteins in differentiated carcinoma, undifferentiated carcinoma with tubular component and pure undifferentiated carcinoma of the stomach.
  • We attempted to clarify the derivation of undifferentiated-type gastric carcinoma with tubular component by using TMA.
  • METHODS: We constructed a TMA system composed of six paraffin blocks in which 274 samples of formalin-fixed gastric carcinoma tissue from 274 patients were embedded.
  • The 274 gastric carcinomas were histopathologically divided into the following three groups according to the degree of differentiation: differentiated-type (D-type), undifferentiated-type with tubular component (UT-type) and pure undifferentiated-type (UP-type).
  • CONCLUSIONS: These findings reveal that gastric carcinomas have distinct expression profiles for tumor suppressor and tumor-related proteins depending on histological types, and support the hypothesis that UT-type carcinomas are derived not only from D-type but also from UP-type carcinomas.
  • [MeSH-major] Adenocarcinoma / genetics. Carcinoma / genetics. Carrier Proteins / metabolism. Cyclin-Dependent Kinase Inhibitor p16 / metabolism. Nuclear Proteins / metabolism. Receptor, ErbB-2 / metabolism. Stomach Neoplasms / genetics. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 16254038.001).
  • [ISSN] 0368-2811
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Carcinoembryonic Antigen; 0 / Carrier Proteins; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / MLH1 protein, human; 0 / Nuclear Proteins; 0 / Tumor Suppressor Protein p53; EC 2.7.10.1 / Receptor, ErbB-2
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16. Mastoraki A, Papanikolaou IS, Sakorafas G, Safioleas M: Facing the challenge of managing linitis plastica--review of the literature. Hepatogastroenterology; 2009 Nov-Dec;56(96):1773-8
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  • Linitis Plastica (LP) denotes a diffuse, intra-murally infiltrating, anaplastic carcinoma in a hollow structure resulting in a shrunken organ with thickened walls.
  • The neoplasm is encountered in every segment of gastrointestinal tract with the gastric localization being the most frequent and simultaneous or successive affection of different digestive sites rarely reported.
  • Symptoms often associated with LP of the stomach include pain and lump in the epigastrium, weight loss, anorexia, dysphagia, nausea and vomiting.
  • Diagnosis of LP-type adenocarcinomas of the stomach has traditionally been achieved by brush cytology and mucosal biopsy.
  • Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) contributes to the detection of abundant, independent malignant cells indicative of an anaplastic neoplasm.
  • [MeSH-major] Linitis Plastica / therapy. Stomach Neoplasms / therapy

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  • (PMID = 20214236.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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17. Augustin G, Jelincic Z, Tentor D, Majerovic M, Matosevic P: Hepatoid adenocarcinoma of the stomach: case report and short notes on immunohistochemical markers. Acta Gastroenterol Belg; 2009 Apr-Jun;72(2):253-6
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  • [Title] Hepatoid adenocarcinoma of the stomach: case report and short notes on immunohistochemical markers.
  • Hepatoid adenocarcinoma of the stomach is a rare type of gastric carcinoma with an extremely poor prognosis.
  • We describe a 72-year-old man who underwent esophagogastroduodenoscopy which revealed 50 mm exulcerated lesion with a central necrosis on the lesser curvature and the posterior wall of the body of the stomach.
  • Gastric biopsy revealed a poorly differentiated (anaplastic) adenocarcinoma.
  • After diagnosis of AFP-producing gastric adenocarcinoma, total gastrectomy, with splenectomy, was performed.
  • Because of the poor prognosis for this histological type of tumor, accurate diagnosis of hepatoid adenocarcinoma is important, and long-term follow-up is required.
  • [MeSH-major] Adenocarcinoma / pathology. Biomarkers, Tumor / analysis. Stomach Neoplasms / pathology

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  • (PMID = 19637784.001).
  • [ISSN] 1784-3227
  • [Journal-full-title] Acta gastro-enterologica Belgica
  • [ISO-abbreviation] Acta Gastroenterol. Belg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / alpha-Fetoproteins
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18. Turi S, Weickert U, Bohrer MH, Riemann JF: [Space-occupying lesion of the pancreas--how frequently not due to a suspected ductal adenocarcinoma?]. Z Gastroenterol; 2006 Feb;44(2):161-6
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  • In 62 patients a clear histological diagnosis was possible on the basis of the biopsy.
  • In 5 patients (7 %) these masses turned out to be metastases of a previously known malignant tumour disease (2 x mammary carcinoma, 2 x gastric carcinoma, 1 x sigmoid carcinoma).
  • Other tumours could be detected in 4 cases (6 %) including a tuberculoma, an endocrine tumour, a fusocellular sarcoma with partial neurogenic differentiation and a large-cell and pleomorphic-cell anaplastic, partly sarcomatoid carcinoma.
  • [MeSH-major] Carcinoma, Pancreatic Ductal / epidemiology. Carcinoma, Pancreatic Ductal / pathology. Pancreatic Neoplasms / epidemiology. Pancreatic Neoplasms / pathology

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  • (PMID = 16456757.001).
  • [ISSN] 0044-2771
  • [Journal-full-title] Zeitschrift für Gastroenterologie
  • [ISO-abbreviation] Z Gastroenterol
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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19. Ji Y, Kuang TT, Tan YS, Chen Y, Zeng HY, Jin DY: Pancreatic primary lymphoma: a case report and review of the literature. Hepatobiliary Pancreat Dis Int; 2005 Nov;4(4):622-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The patient received a Whipple's operation and intraoperative frozen sections of the mass showed an anaplastic carcinoma.
  • RESULTS: Grossly the tumor involved the pancreatic head, soft in consistence and invaded part of the gastric wall.
  • CONCLUSIONS: The proper diagnosis of the tumor should be made with CD20 and Bcl-6 immunohistochemical study.
  • Radical surgery is indicated for resectable carcinoma but not for a chemosensitive lymphoma.
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged

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  • (PMID = 16286277.001).
  • [ISSN] 1499-3872
  • [Journal-full-title] Hepatobiliary & pancreatic diseases international : HBPD INT
  • [ISO-abbreviation] HBPD INT
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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20. Miettinen M: From morphological to molecular diagnosis of soft tissue tumors. Adv Exp Med Biol; 2006;587:99-113
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  • [Title] From morphological to molecular diagnosis of soft tissue tumors.
  • Many sarcomas are known to have such fusions, and the demonstration of the fusion transcripts in tumor tissue is of great value in specific diagnosis of synovial sarcoma (SYT-SSX), Ewing sarcoma (EWS-Fli1), clear cell sarcoma (EWS-ATF1), myxoid liposarcoma (FUS-CHOP), and other sarcomas.
  • Demonstration of SYT-SSX and EWS-ATF1 fusion assists in the diagnosis of synovial and clear cell sarcomas in unusual locations, such as the gastrointestinal tract, where these tumors occur with low frequency.
  • In two exceptional instances, the same translocation and gene fusion occurs in two unrelated diseases: ETV6-NTRK fusion in infantile fibrosarcoma and secretory carcinoma of the breast, and ALK-TPM3 fusion in inflammatory myofibroblastic tumor and large cell anaplastic lymphoma.
  • KIT exon 11 mutations (in frame deletions, point mutations, and duplications) occur in GISTs of all locations, whereas a characteristic exon 9 insertion-duplication AY502-503 is nearly specific for intestinal vs gastric tumors.
  • In contrast, PDGFRA mutations are nearly specific for gastric GISTs, especially those with epithelioid morphology.

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  • (PMID = 17163160.001).
  • [ISSN] 0065-2598
  • [Journal-full-title] Advances in experimental medicine and biology
  • [ISO-abbreviation] Adv. Exp. Med. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 70
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21. Zenda T, Taniguchi K, Hashimoto T, Takeshita Y, Choto S, Masunaga T, Minato H: Metastatic colon cancer mimicking Crohn's disease. Ann Diagn Pathol; 2007 Dec;11(6):427-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Although upper gastrointestinal endoscopy demonstrated signet-ring cell gastric carcinoma, colonoscopy and barium enema study yielded findings mimicking Crohn's disease in the colon, that is, skipping longitudinal ulcer scarlike strictures, cobblestone appearance, segmental stricture, and pseudosacculations.
  • After total gastrectomy and right-sided hemicolectomy, the final diagnosis of gastric cancer extensively involving the colon, and not of Crohn's disease complicating gastric cancer, was established.
  • Pathologic examination showed that anaplastic cancer with exuberant desmoplastic reaction and infiltration along the mesenteric border principally accounted for the morphological similarities noted between Crohn's disease and metastatic colon cancer in this case.
  • [MeSH-major] Adenocarcinoma / secondary. Colonic Neoplasms / secondary. Crohn Disease / pathology. Stomach Neoplasms / pathology
  • [MeSH-minor] Aged. Barium Sulfate. Colectomy. Colonoscopy. Diagnosis, Differential. Enema. Female. Gastrectomy. Humans. Hydronephrosis / etiology. Intestinal Obstruction / etiology. Tomography, X-Ray Computed


22. Lee SM, Oh YL, Kim KM, Ko YH, Lee J: Coexistence of EBV associated nasopharyngeal undifferentiated carcinoma and gastric lymphoepithelioma-like carcinoma. Pathology; 2010 Dec;42(7):684-6
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  • [Title] Coexistence of EBV associated nasopharyngeal undifferentiated carcinoma and gastric lymphoepithelioma-like carcinoma.
  • [MeSH-major] Carcinoma / virology. Epstein-Barr Virus Infections / complications. Neoplasms, Multiple Primary / virology. Stomach Neoplasms / virology

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  • (PMID = 21080882.001).
  • [ISSN] 1465-3931
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] Nasopharyngeal carcinoma
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23. Murata K, Inoue H, Kozuka Y: Gastric metastases from anaplastic pancreatic cancer. Clin Gastroenterol Hepatol; 2007 Jan;5(1):e3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gastric metastases from anaplastic pancreatic cancer.
  • [MeSH-major] Carcinoma / pathology. Pancreatic Neoplasms / pathology. Stomach Neoplasms / secondary

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  • (PMID = 17234552.001).
  • [ISSN] 1542-7714
  • [Journal-full-title] Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • [ISO-abbreviation] Clin. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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