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1. Liu R, Li X, Tulpule A, Zhou Y, Scehnet JS, Zhang S, Lee JS, Chaudhary PM, Jung J, Gill PS: KSHV-induced notch components render endothelial and mural cell characteristics and cell survival. Blood; 2010 Jan 28;115(4):887-95
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  • In addition, KSHV induced the expression of endothelial precursor cell marker (CD133) and mural cell markers (calponin, desmin, and smooth muscle alpha actin), suggesting dedifferentiation and trans-differentiation.

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  • (PMID = 19965636.001).
  • [ISSN] 1528-0020
  • [Journal-full-title] Blood
  • [ISO-abbreviation] Blood
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA 079218-07; United States / NCI NIH HHS / CA / R01 CA085177; United States / NCI NIH HHS / CA / CA082057-13; United States / NCI NIH HHS / CA / R01 CA082057; United States / NCI NIH HHS / CA / R01 CA079218; United States / NCI NIH HHS / CA / R01 CA115284; United States / NCI NIH HHS / CA / CA082057; United States / NCI NIH HHS / CA / CA115284; United States / NCI NIH HHS / CA / R01CA085177; United States / NCI NIH HHS / CA / R01 CA031363; United States / NCI NIH HHS / CA / R01 CA082057-13
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Calcium-Binding Proteins; 0 / DLL4 protein, human; 0 / Intercellular Signaling Peptides and Proteins; 0 / Membrane Proteins; 0 / NOTCH1 protein, human; 0 / NOTCH2 protein, human; 0 / NOTCH3 protein, human; 0 / NOTCH4 protein, human; 0 / Proto-Oncogene Proteins; 0 / RNA, Small Interfering; 0 / Receptor, Notch1; 0 / Receptor, Notch2; 0 / Receptors, Notch; 134324-36-0 / Serrate proteins
  • [Other-IDs] NLM/ PMC2815507
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2. Arakawa E, Hasegawa K: Benidipine, a calcium channel blocker, regulates proliferation and phenotype of vascular smooth muscle cells. J Pharmacol Sci; 2006 Feb;100(2):149-56
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  • These data suggest that benidipine may arrest the growth of VSMCs, thereby preventing cell dedifferentiation.

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  • (PMID = 16474204.001).
  • [ISSN] 1347-8613
  • [Journal-full-title] Journal of pharmacological sciences
  • [ISO-abbreviation] J. Pharmacol. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Calcium Channel Blockers; 0 / Dihydropyridines; 4G9T91JS7E / benidipine; EC 2.7.11.1 / Ribosomal Protein S6 Kinases, 70-kDa
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3. Weksler BB, Subileau EA, Perrière N, Charneau P, Holloway K, Leveque M, Tricoire-Leignel H, Nicotra A, Bourdoulous S, Turowski P, Male DK, Roux F, Greenwood J, Romero IA, Couraud PO: Blood-brain barrier-specific properties of a human adult brain endothelial cell line. FASEB J; 2005 Nov;19(13):1872-4
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  • This cell line, termed hCMEC/D3, showed a stable normal karyotype, maintained contact-inhibited monolayers in tissue culture, exhibited robust proliferation in response to endothelial growth factors, and formed capillary tubes in matrix but no colonies in soft agar. hCMEC/D3 cells expressed telomerase and grew indefinitely without phenotypic dedifferentiation.
  • Thus, hCMEC/D3 represents the first stable, fully characterized, well-differentiated human brain endothelial cell line and should serve as a widely usable research tool.

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  • (PMID = 16141364.001).
  • [ISSN] 1530-6860
  • [Journal-full-title] FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • [ISO-abbreviation] FASEB J.
  • [Language] eng
  • [Grant] United Kingdom / Multiple Sclerosis Society / / 630; United Kingdom / Multiple Sclerosis Society / / 675; United Kingdom / Wellcome Trust / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD31; 0 / Antigens, Polyomavirus Transforming; 0 / Cadherins; 0 / Cytokines; 0 / Drug Combinations; 0 / Laminin; 0 / Proteoglycans; 0 / cadherin 5; 0 / von Willebrand Factor; 119978-18-6 / matrigel; 63231-63-0 / RNA; 9002-18-0 / Agar; 9007-34-5 / Collagen; EC 2.7.7.49 / Telomerase
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4. Kalayarasan R, Ananthakrishnan N, Kate V, Basu D: Estrogen and progesterone receptors in esophageal carcinoma. Dis Esophagus; 2008;21(4):298-303
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  • The receptor status was correlated with tumor type, tumor differentiation and tumor stage.
  • For SCC it was seen that ERbeta positivity in tumor cells increases with dedifferentiation and increasing tumor stage.
  • ERbeta is over-expressed in poorly differentiated SCC and AC compared to NEM.
  • Thus ERbeta may be a marker for poor biological behavior, that is dedifferentiation or higher stage of disease.

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  • (PMID = 18477250.001).
  • [ISSN] 1442-2050
  • [Journal-full-title] Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
  • [ISO-abbreviation] Dis. Esophagus
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Estrogen; 0 / Receptors, Progesterone
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5. Shi Y, Zou M, Baitei EY, Alzahrani AS, Parhar RS, Al-Makhalafi Z, Al-Mohanna FA: Cannabinoid 2 receptor induction by IL-12 and its potential as a therapeutic target for the treatment of anaplastic thyroid carcinoma. Cancer Gene Ther; 2008 Feb;15(2):101-7
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  • [Title] Cannabinoid 2 receptor induction by IL-12 and its potential as a therapeutic target for the treatment of anaplastic thyroid carcinoma.
  • Anaplastic thyroid carcinoma is the most aggressive type of thyroid malignancies.
  • Previously, we demonstrated that tumorigenicity of anaplastic thyroid carcinoma cell line ARO was significantly reduced following interleukin (IL)-12 gene transfer.
  • We suspected that tumor target structure in ARO/IL-12 cells might be changed and such a change may make them more susceptible to be killed through mechanisms apart from natural killer-dependent pathway.
  • These data suggest that CB2 overexpression may contribute to the regression of human anaplastic thyroid tumor in nude mice following IL-12 gene transfer.
  • Given that cannabinoids have shown antitumor effects in many types of cancer models, CB2 may be a viable therapeutic target for the treatment of anaplastic thyroid carcinoma.

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  • (PMID = 18197164.001).
  • [ISSN] 1476-5500
  • [Journal-full-title] Cancer gene therapy
  • [ISO-abbreviation] Cancer Gene Ther.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Receptor, Cannabinoid, CB2; 187348-17-0 / Interleukin-12
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6. Famulski KS, Einecke G, Sis B, Mengel M, Hidalgo LG, Kaplan B, Halloran PF: Defining the canonical form of T-cell-mediated rejection in human kidney transplants. Am J Transplant; 2010 Apr;10(4):810-20
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  • Despite marked changes in transcriptome indicating tissue injury and dedifferentiation, all kidneys with molecularly defined TCMR, even with v lesions or late rejection, demonstrated excellent recovery of function at 6 months with no graft loss (mean follow-up 2.5 years).

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  • (PMID = 20132168.001).
  • [ISSN] 1600-6143
  • [Journal-full-title] American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • [ISO-abbreviation] Am. J. Transplant.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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7. Han WK, Alinani A, Wu CL, Michaelson D, Loda M, McGovern FJ, Thadhani R, Bonventre JV: Human kidney injury molecule-1 is a tissue and urinary tumor marker of renal cell carcinoma. J Am Soc Nephrol; 2005 Apr;16(4):1126-34
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  • Human kidney injury molecule-1 (hKIM-1) is a type 1 transmembrane protein that is not detectable in normal kidney tissue but is expressed at high levels in human and rodent kidneys with dedifferentiated proximal tubule epithelial cells after ischemic or toxic injury.

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  • (PMID = 15744000.001).
  • [ISSN] 1046-6673
  • [Journal-full-title] Journal of the American Society of Nephrology : JASN
  • [ISO-abbreviation] J. Am. Soc. Nephrol.
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / DK38452; United States / NIDDK NIH HHS / DK / DK46267; United States / NIDDK NIH HHS / DK / 5F32DK10036; United States / NIDDK NIH HHS / DK / 5KO8DK64075; United States / NIDDK NIH HHS / DK / R37 DK039773; United States / NIDDK NIH HHS / DK / DK39773; United States / NIDDK NIH HHS / DK / K08 DK064075; United States / NIDDK NIH HHS / DK / F32 DK010036; United States / NIDDK NIH HHS / DK / R01 DK046267; United States / NIDDK NIH HHS / DK / P01 DK038452; United States / NIDDK NIH HHS / DK / R01 DK039773
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / HAVCR1 protein, human; 0 / Membrane Glycoproteins; 0 / Receptors, Virus
  • [Other-IDs] NLM/ NIHMS4429; NLM/ PMC1307501
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8. Vial C, Zúñiga LM, Cabello-Verrugio C, Cañón P, Fadic R, Brandan E: Skeletal muscle cells express the profibrotic cytokine connective tissue growth factor (CTGF/CCN2), which induces their dedifferentiation. J Cell Physiol; 2008 May;215(2):410-21
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  • [Title] Skeletal muscle cells express the profibrotic cytokine connective tissue growth factor (CTGF/CCN2), which induces their dedifferentiation.
  • CTGF had an important inhibitory effect on muscle differentiation evaluated by the decrease in the nuclear translocation of the early muscle regulatory factor myogenin and myosin.
  • Remarkable, CTGF treatment of myoblasts induced their dedifferentiation, characterized by down regulating MyoD and desmin, two markers of committed myoblasts, together with a strong reorganization of cytoskeletal filaments.
  • These results provide novel evidence for the underlying mechanisms and participation of skeletal muscle cells in the synthesis and role of CTGF inducing fibrosis, inhibiting myogenesis and dedifferentiating myoblasts.
  • [MeSH-major] Cell Dedifferentiation. Immediate-Early Proteins / metabolism. Intercellular Signaling Peptides and Proteins / metabolism. Muscle, Skeletal / cytology. Muscle, Skeletal / metabolism
  • [MeSH-minor] Animals. Biological Transport / drug effects. Cell Differentiation / drug effects. Cell Line. Cell Nucleus / metabolism. Connective Tissue Growth Factor. Cytoskeleton / drug effects. Desmin / metabolism. Down-Regulation. Extracellular Matrix Proteins / biosynthesis. Lysophospholipids / pharmacology. Mice. Muscle Fibers, Skeletal / drug effects. Muscle Fibers, Skeletal / metabolism. MyoD Protein / metabolism. Myoblasts / cytology. Myoblasts / drug effects. Myoblasts / metabolism. Myogenin / metabolism. Myosins / metabolism. Recombinant Proteins / pharmacology. Transforming Growth Factor beta / pharmacology

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  • [Copyright] (c) 2007 Wiley-Liss, Inc.
  • (PMID = 18064627.001).
  • [ISSN] 1097-4652
  • [Journal-full-title] Journal of cellular physiology
  • [ISO-abbreviation] J. Cell. Physiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ctgf protein, mouse; 0 / Desmin; 0 / Extracellular Matrix Proteins; 0 / Immediate-Early Proteins; 0 / Intercellular Signaling Peptides and Proteins; 0 / Lysophospholipids; 0 / MyoD Protein; 0 / Myogenin; 0 / Recombinant Proteins; 0 / Transforming Growth Factor beta; 139568-91-5 / Connective Tissue Growth Factor; 22002-87-5 / lysophosphatidic acid; EC 3.6.4.1 / Myosins
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9. Deorah S, Lynch CF, Sibenaller ZA, Ryken TC: Trends in brain cancer incidence and survival in the United States: Surveillance, Epidemiology, and End Results Program, 1973 to 2001. Neurosurg Focus; 2006;20(4):E1
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  • The incidence of brain cancer increased until 1987, when the annual percentage of change reversed direction, decreasing from 1.68 to 20.44%.
  • Rising trends were noticed for glioblastoma multiforme (GBM), oligodendroglioma, anaplastic astrocytoma, medulloblastoma, and mixed glioma, and falling trends were observed for astrocytoma not otherwise specified and malignant glioma.

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  • (PMID = 16709014.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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10. Damri M, Granot G, Ben-Meir H, Avivi Y, Plaschkes I, Chalifa-Caspi V, Wolfson M, Fraifeld V, Grafi G: Senescing cells share common features with dedifferentiating cells. Rejuvenation Res; 2009 Dec;12(6):435-43
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Senescing cells share common features with dedifferentiating cells.
  • Dedifferentiation signifies the capacity of somatic cells to acquire stem cell-like properties.
  • Dedifferentiation also characterizes the transition of differentiated leaf cells into protoplasts (plant cells devoid of cell walls), a transition accompanied by widespread chromatin decondensation.
  • Transcriptome profiling of dedifferentiating protoplast cells revealed striking similarities with senescing cells; both display a large increase in the expression of genes of specific transcription factor (TF) families, including ANAC, WRKY, bZIP, and C2H2.
  • Further analysis showed that leaves induced to senesce by exposure to dark display characteristic features of dedifferentiating cells, including chromatin decondensation, disruption of the nucleolus, and condensation of rRNA genes.
  • Considering that premature senescence can be induced by various stress conditions both in plant and animal cells, our results suggest that the response of plant and also animal cells to certain stresses converges on cellular dedifferentiation whereby cells first acquire stem cell-like state prior to acquisition of a new cell fate (e.g., reentry into the cell cycle or death).
  • [MeSH-major] Arabidopsis / cytology. Cell Aging / physiology. Cell Dedifferentiation / physiology

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  • (PMID = 20041737.001).
  • [ISSN] 1557-8577
  • [Journal-full-title] Rejuvenation research
  • [ISO-abbreviation] Rejuvenation Res
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Ribosomal; 0 / Transcription Factors; EC 2.7.11.24 / Mitogen-Activated Protein Kinases
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11. Nakamura Y, Yumiba T, Yamasaki Y, Momiyama T, Ito A, Akamaru Y, Kasugai T: Dedifferentiated liposarcoma in the retroperitoneum in an atomic bomb survivor: report of a case. Case Rep Gastroenterol; 2008;2(3):338-45
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  • [Title] Dedifferentiated liposarcoma in the retroperitoneum in an atomic bomb survivor: report of a case.
  • The final histopathological diagnosis of tumors 1 and 2 was malignant fibrous histiocytoma of the retroperitoneum, and tumor 3 was a well-differentiated liposarcoma.
  • By the presence of the liposarcoma, tumor 1 and 2 were thought to be the dedifferentiated areas of liposarcomas.

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  • (PMID = 21490866.001).
  • [ISSN] 1662-0631
  • [Journal-full-title] Case reports in gastroenterology
  • [ISO-abbreviation] Case Rep Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Other-IDs] NLM/ PMC3075194
  • [Keywords] NOTNLM ; Atomic bomb survivor / Dedifferentiated liposarcoma / Malignant fibrous histiocytoma
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12. Sellaro TL, Ravindra AK, Stolz DB, Badylak SF: Maintenance of hepatic sinusoidal endothelial cell phenotype in vitro using organ-specific extracellular matrix scaffolds. Tissue Eng; 2007 Sep;13(9):2301-10
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  • SECs represent a highly specialized endothelial cell (EC) population, and traditional methods of SEC isolation from the liver initiate a process of SEC dedifferentiation.
  • The effect of the ECM substrate upon SEC dedifferentiation was evaluated using scanning electron microscopy (SEM) and confocal microscopy.
  • When SECs alone were cultured on uncoated glass slides, collagen I, UBM-ECM, or SIS-ECM, SECs showed signs of dedifferentiation after 1 day.
  • In contrast, SECs alone cultured on L-ECM maintained their differentiated phenotype for at least 3 days, indicated by the presence of many fenestrations on SEC surface, expression of anti-rat hepatic sinusoidal endothelial cells mouse IgG MoAb (SE-1), and lack of expression of CD31.
  • At all time points, SECs cocultured with hepatocytes on L-ECM maintained the greatest degree of differentiation.
  • The present study demonstrated that the acellular ECM scaffold derived from the liver maintained SEC differentiation in culture longer than any of the tested substrate materials.

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  • (PMID = 17561801.001).
  • [ISSN] 1076-3279
  • [Journal-full-title] Tissue engineering
  • [ISO-abbreviation] Tissue Eng.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biocompatible Materials
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13. Durcova-Hills G, Tang F, Doody G, Tooze R, Surani MA: Reprogramming primordial germ cells into pluripotent stem cells. PLoS One; 2008;3(10):e3531
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  • However, PGCs can be induced to dedifferentiate back to a pluripotent state as embryonic germ (EG) cells when exposed to exogenous signaling molecules, FGF-2, LIF and SCF.
  • METHODOLOGY AND PRINCIPAL FINDINGS: Here we show that Trichostatin A (TSA), an inhibitor of histone deacetylases, is a highly potent agent that can replace FGF-2 to induce dedifferentiation of PGCs into EG cells.
  • A key early event during dedifferentiation of PGCs in response to FGF-2 or TSA is the down-regulation of Blimp1, which reverses and apparently relieves the cell fate restriction imposed by it.
  • CONCLUSIONS/SIGNIFICANCE: We propose that dedifferentiation of PGCs into EG cells may provide significant mechanistic insights on early events associated with reprogramming of committed cells to a pluripotent state.
  • [MeSH-major] Cell Dedifferentiation / physiology. Germ Cells / physiology. Pluripotent Stem Cells / physiology

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  • (PMID = 18953407.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / G108/500; United Kingdom / Biotechnology and Biological Sciences Research Council / / ; United Kingdom / Medical Research Council / / ; United Kingdom / Wellcome Trust / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Leukemia Inhibitory Factor; 0 / Lif protein, mouse; 0 / Prdm1 protein, mouse; 0 / STAT3 Transcription Factor; 0 / Stat3 protein, mouse; 0 / Transcription Factors
  • [Other-IDs] NLM/ PMC2567847
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14. Weinberg N, Ouziel-Yahalom L, Knoller S, Efrat S, Dor Y: Lineage tracing evidence for in vitro dedifferentiation but rare proliferation of mouse pancreatic beta-cells. Diabetes; 2007 May;56(5):1299-304
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  • [Title] Lineage tracing evidence for in vitro dedifferentiation but rare proliferation of mouse pancreatic beta-cells.
  • Recent studies have raised the possibility that human beta-cells can undergo dedifferentiation and give rise to highly proliferative mesenchymal cells, which retain the potential to redifferentiate into beta-cells.
  • To directly test whether cultured beta-cells dedifferentiate, we applied genetic lineage tracing in mice.
  • Differentiated beta-cells were heritably labeled using the Cre-lox system, and their fate in culture was followed.
  • We provide evidence that mouse beta-cells can undergo dedifferentiation in vitro into an insulin-, pdx1-, and glut2-negative state.
  • However, dedifferentiated beta-cells only rarely proliferate under standard culture conditions and are eventually eliminated from cultures.
  • [MeSH-major] Cell Differentiation / physiology. Cell Division / physiology. Insulin-Secreting Cells / cytology

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  • (PMID = 17303800.001).
  • [ISSN] 1939-327X
  • [Journal-full-title] Diabetes
  • [ISO-abbreviation] Diabetes
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA Primers; 0 / Insulin; 147336-22-9 / Green Fluorescent Proteins
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15. Al-Attar A, Gossage L, Fareed KR, Shehata M, Mohammed M, Zaitoun AM, Soomro I, Lobo DN, Abbotts R, Chan S, Madhusudan S: Human apurinic/apyrimidinic endonuclease (APE1) is a prognostic factor in ovarian, gastro-oesophageal and pancreatico-biliary cancers. Br J Cancer; 2010 Feb 16;102(4):704-9
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  • In gastro-oesophageal cancers previously exposed to neoadjuvant chemotherapy, 34.8% (16 out of 46) of tumours were positive in the nucleus and this correlated with shorter overall survival (P=0.005), whereas cytoplasmic localisation correlated with tumour dedifferentiation (P=0.034).
  • Absence of cytoplasmic staining was associated with perineural invasion (P=0.007), vascular invasion (P=0.05), and poorly differentiated tumours (P=0.068).


16. Ricarte-Filho JC, Fuziwara CS, Yamashita AS, Rezende E, da-Silva MJ, Kimura ET: Effects of let-7 microRNA on Cell Growth and Differentiation of Papillary Thyroid Cancer. Transl Oncol; 2009 Dec;2(4):236-41
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  • [Title] Effects of let-7 microRNA on Cell Growth and Differentiation of Papillary Thyroid Cancer.
  • Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy and RET/PTC rearrangements represent key genetic events frequently associated to this cancer, enhancing proliferation and dedifferentiation by activation of the RET/PTC-RAS-BRAF-mitogen-activated protein kinase (MAPK) pathway.
  • In addition, let-7 enhanced transcriptional expression of molecular markers of thyroid differentiation such as TITF1 and TG.
  • Moreover, let-7f effects on thyroid growth and differentiation might attenuate neoplastic process of RET/PTC papillary thyroid oncogenesis through impairment of MAPK signaling pathway activation.
  • This is the first functional demonstration of an association of let-7 with thyroid cancer cell growth and differentiation.


17. Bussolati B, Camussi G: Stem cells in acute kidney injury. Contrib Nephrol; 2007;156:250-8
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  • The administered SCs may, however, modify the microenvironment by inducing dedifferentiation and proliferation of tubular cells surviving to injury or by allowing expansion of resident SCs.
  • Therefore, therapeutic strategies to exploit the regenerative potential of SCs may be based on the administration of ex vivo expanded SCs or on stimulation of expansion and differentiation of local progenitor/SC populations.
  • [MeSH-minor] Animals. Bone Marrow Cells / cytology. Bone Marrow Cells / physiology. Cell Differentiation / physiology. Cell Movement / physiology. Disease Models, Animal. Humans. Kidney / cytology. Kidney / pathology. Kidney / physiology. Rats. Regeneration / physiology

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  • (PMID = 17464134.001).
  • [ISSN] 0302-5144
  • [Journal-full-title] Contributions to nephrology
  • [ISO-abbreviation] Contrib Nephrol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 37
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18. Takano Y, Yamauchi K, Hiramatsu N, Kasai A, Hayakawa K, Yokouchi M, Yao J, Kitamura M: Recovery and maintenance of nephrin expression in cultured podocytes and identification of HGF as a repressor of nephrin. Am J Physiol Renal Physiol; 2007 May;292(5):F1573-82
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  • VRAD maintained expression of nephrin for extended periods, which was associated with the differentiated phenotype of podocytes.
  • Using the VRAD-primed podocytes, we revealed that expression of nephrin mRNA as well as nephrin promoter activity was suppressed by a putative dedifferentiation factor of podocytes, hepatocyte growth factor.
  • [MeSH-minor] Animals. Biomarkers / metabolism. Calcitriol / pharmacology. Cell Differentiation. Cell Line. Culture Media / pharmacology. Dexamethasone / pharmacology. Drug Combinations. Gene Expression / drug effects. Glucocorticoids / pharmacology. Humans. Mice. Promoter Regions, Genetic / drug effects. RNA, Messenger / metabolism. Recombinant Proteins / pharmacology. Time Factors. Tretinoin / pharmacology

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  • (PMID = 17244893.001).
  • [ISSN] 1931-857X
  • [Journal-full-title] American journal of physiology. Renal physiology
  • [ISO-abbreviation] Am. J. Physiol. Renal Physiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Culture Media; 0 / Drug Combinations; 0 / Glucocorticoids; 0 / Membrane Proteins; 0 / RNA, Messenger; 0 / Recombinant Proteins; 0 / nephrin; 5688UTC01R / Tretinoin; 67256-21-7 / Hepatocyte Growth Factor; 7S5I7G3JQL / Dexamethasone; FXC9231JVH / Calcitriol
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19. Cannella S, Santoro A, Bruno G, Pillon M, Mussolin L, Mangili G, Rosolen A, Aricò M: Germline mutations of the perforin gene are a frequent occurrence in childhood anaplastic large cell lymphoma. Cancer; 2007 Jun 15;109(12):2566-71
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  • [Title] Germline mutations of the perforin gene are a frequent occurrence in childhood anaplastic large cell lymphoma.
  • Anaplastic large cell lymphoma (ALCL) accounts for 10% to 15% of all childhood lymphomas.
  • The remaining 4 mutations were previously described; in particular, the 272C>T mutation (resulting in the A91V amino acid change) was found in 8 patients, whereas the 368G>A (R123H), 695G>A (R232H), and 1262T>G (F421C) mutations were all found in 1 case each.
  • [MeSH-major] Germ-Line Mutation / genetics. Lymphoma, Large-Cell, Anaplastic / genetics. Pore Forming Cytotoxic Proteins / genetics
  • [MeSH-minor] Case-Control Studies. Child. DNA Mutational Analysis. Genetic Predisposition to Disease. Heterozygote. Humans. Perforin. Prospective Studies

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  • [Copyright] Copyright 2007 American Cancer Society.
  • (PMID = 17477373.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / PRF1 protein, human; 0 / Pore Forming Cytotoxic Proteins; 126465-35-8 / Perforin
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20. D'Alise AM, Amabile G, Iovino M, Di Giorgio FP, Bartiromo M, Sessa F, Villa F, Musacchio A, Cortese R: Reversine, a novel Aurora kinases inhibitor, inhibits colony formation of human acute myeloid leukemia cells. Mol Cancer Ther; 2008 May;7(5):1140-9
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  • The demonstration that the small synthetic molecule reversine [2-(4-morpholinoanilino)-N6-cyclohexyladenine] promotes the dedifferentiation of committed cells into multipotent progenitor-type cells has raised hopes on the exploitation of this small chemical tool for the generation of stem cells.
  • [MeSH-minor] Aurora Kinase B. Aurora Kinases. Binding Sites / drug effects. Cell Differentiation. Cell Line, Tumor. Cell Proliferation. Dose-Response Relationship, Drug. HeLa Cells. Histones / metabolism. Humans. Models, Molecular. Phosphorylation. Polyploidy

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  • (PMID = 18483302.001).
  • [ISSN] 1535-7163
  • [Journal-full-title] Molecular cancer therapeutics
  • [ISO-abbreviation] Mol. Cancer Ther.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Histones; 0 / Morpholines; 0 / Protein Kinase Inhibitors; 0 / Purines; EC 2.7.11.1 / AURKB protein, human; EC 2.7.11.1 / Aurora Kinase B; EC 2.7.11.1 / Aurora Kinases; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; Z499CLJ023 / 2-(4-morpholinoanilino)-6-cyclohexylaminopurine
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21. Alsaad KO, Serra S, Perren A, Hsieh E, Chetty R: CK19 and CD99 immunoexpression profile in goblet cell (mucin-producing neuroendocrine tumors) and classical carcinoids of the vermiform appendix. Int J Surg Pathol; 2007 Jul;15(3):252-7
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  • Conversely, the loss of expression of CD99 has been suggested to play a role in the tumorigenesis and dedifferentiation and is associated with poor outcome in some malignancies.

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  • (PMID = 17652531.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Biomarkers, Tumor; 0 / CD99 protein, human; 0 / Cell Adhesion Molecules; 0 / Keratin-19
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22. Schmal H, Mehlhorn AT, Fehrenbach M, Müller CA, Finkenzeller G, Südkamp NP: Regulative mechanisms of chondrocyte adhesion. Tissue Eng; 2006 Apr;12(4):741-50
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  • Therefore, our objective was to study the influence of differentiation status on cellular attachment.
  • Following dedifferentiation after the second passage, adhesion to collagen types I (-84%) and II (-46%) decreased, whereas adhesion to fibrinogen (+59%) and fibronectin (+43%) increased.
  • Matrix design in cartilage engineering must meet the biological demands of amplified cells, because adhesion of chondrocytes depends on their differentiation status and is regulated by bFGF.
  • [MeSH-minor] Animals. Cattle. Cell Adhesion. Cell Culture Techniques. Cell Differentiation. Cells, Cultured. Collagen Type I / pharmacology. Collagen Type I / physiology. Collagen Type I / ultrastructure. Collagen Type II / pharmacology. Collagen Type II / physiology. Collagen Type II / ultrastructure. Dose-Response Relationship, Drug. Extracellular Matrix / physiology. Extracellular Matrix / ultrastructure. Fibrinogen / pharmacology. Fibrinogen / physiology. Fibroblast Growth Factor 2 / pharmacology. Fibronectins / physiology. Focal Adhesions / physiology. Focal Adhesions / ultrastructure. Patella / cytology

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  • (PMID = 16674288.001).
  • [ISSN] 1076-3279
  • [Journal-full-title] Tissue engineering
  • [ISO-abbreviation] Tissue Eng.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Collagen Type I; 0 / Collagen Type II; 0 / Fibronectins; 103107-01-3 / Fibroblast Growth Factor 2; 9001-32-5 / Fibrinogen
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23. Nasr M, Ayyad SB, El-Lamie IK, Mikhail MY: Expression of matrix metalloproteinase-2 in preinvasive and invasive carcinoma of the uterine cervix. Eur J Gynaecol Oncol; 2005;26(2):199-202
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  • PURPOSE: To study the immunohistochemical expression of matrix metalloproteinase-2 (MMP-2) in preinvasive and invasive carcinoma of the uterine cervix so as to demonstrate whether the expression of MMP-2 is an early or late event in the process of dedifferentiation and cancer progression.
  • [MeSH-minor] Adult. Cell Transformation, Neoplastic / metabolism. Disease Progression. Female. Humans. Middle Aged

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  • (PMID = 15857029.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] EC 3.4.24.24 / Matrix Metalloproteinase 2
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24. Driesen RB, Verheyen FK, Debie W, Blaauw E, Babiker FA, Cornelussen RN, Ausma J, Lenders MH, Borgers M, Chaponnier C, Ramaekers FC: Re-expression of alpha skeletal actin as a marker for dedifferentiation in cardiac pathologies. J Cell Mol Med; 2009 May;13(5):896-908
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  • [Title] Re-expression of alpha skeletal actin as a marker for dedifferentiation in cardiac pathologies.
  • Differentiation of foetal cardiomyocytes is accompanied by sequential actin isoform expression, i.e. down-regulation of the 'embryonic' alpha smooth muscle actin, followed by an up-regulation of alpha skeletal actin (alphaSKA) and a final predominant expression of alpha cardiac actin (alphaCA).
  • Our objective was to detect whether re-expression of alphaSKA occurred during cardiomyocyte dedifferentiation, a phenomenon that has been observed in different pathologies characterized by myocardial dysfunction.
  • Furthermore, actin isoform expression was investigated in left ventricle samples of rabbit hearts suffering from pressure- and volume-overload and in adult rabbit ventricular cardiomyocytes during dedifferentiation in vitro.
  • Dedifferentiating cardiomyocytes in vitro revealed a degradation of the contractile apparatus and local re-expression of alphaSKA.
  • The expression of alphaSKA in adult dedifferentiating cardiomyocytes, in combination with PAS-positive glycogen and decreased cardiotin expression, offers an additional tool in the evaluation of myocardial dysfunction and indicates major changes in the contractile properties of these cells.
  • [MeSH-major] Actins / metabolism. Cell Dedifferentiation / physiology. Myocytes, Cardiac / metabolism. Myocytes, Cardiac / pathology
  • [MeSH-minor] Actinin / metabolism. Animals. Aortic Valve Insufficiency / metabolism. Aortic Valve Insufficiency / pathology. Atrial Fibrillation / metabolism. Atrial Fibrillation / pathology. Biomarkers / metabolism. Cells, Cultured. Coronary Artery Disease / metabolism. Coronary Artery Disease / pathology. Down-Regulation / physiology. Female. Glycogen / metabolism. Goats. Humans. Myocardial Stunning / metabolism. Myocardial Stunning / pathology. Protein Isoforms / metabolism. Rabbits. Up-Regulation / physiology

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  • (PMID = 19538254.001).
  • [ISSN] 1582-4934
  • [Journal-full-title] Journal of cellular and molecular medicine
  • [ISO-abbreviation] J. Cell. Mol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Actins; 0 / Biomarkers; 0 / Protein Isoforms; 0 / cardiotin; 11003-00-2 / Actinin; 9005-79-2 / Glycogen
  • [Other-IDs] NLM/ PMC3823406
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25. Löfstedt T, Fredlund E, Noguera R, Navarro S, Holmquist-Mengelbier L, Beckman S, Påhlman S, Axelson H: HIF-1alpha induces MXI1 by alternate promoter usage in human neuroblastoma cells. Exp Cell Res; 2009 Jul 1;315(11):1924-36
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  • Tumor hypoxia and HIF expression have also been associated with a dedifferentiated phenotype and increased aggressiveness.

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  • (PMID = 19254710.001).
  • [ISSN] 1090-2422
  • [Journal-full-title] Experimental cell research
  • [ISO-abbreviation] Exp. Cell Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Basic Helix-Loop-Helix Transcription Factors; 0 / HIF1A protein, human; 0 / Hypoxia-Inducible Factor 1, alpha Subunit; 0 / MXI1 protein, human; 0 / RNA, Small Interfering; 0 / Tumor Suppressor Proteins
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26. Liu Y, Jiang X, Yu MK, Dong J, Zhang X, Tsang LL, Chung YW, Li T, Chan HC: Switching from bone marrow-derived neurons to epithelial cells through dedifferentiation and translineage redifferentiation. Cell Biol Int; 2010 Nov;34(11):1075-83
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  • [Title] Switching from bone marrow-derived neurons to epithelial cells through dedifferentiation and translineage redifferentiation.
  • We investigated whether BM-MSCs that had terminally differentiated into the neural or epithelial lineage could be induced to transdifferentiate into the other phenotype in vitro.
  • Our results reveal that neuronal phenotypic cells derived from adult rat bone marrow cells can be switched to epithelial phenotypic cells, or vice versa, by culture manipulation allowing the differentiated cells to go through, first, dedifferentiation and then redifferentiation to another phenotype.
  • Direct transdifferentiation from differentiated neuronal or epithelial phenotype to the other differentiated phenotype cannot be observed even when appropriate culture conditions are provided.
  • Thus, dedifferentiation appears to be a prerequisite for changing fate and differentiating into a different lineage from a differentiated cell population.
  • [MeSH-major] Bone Marrow Cells / cytology. Cell Dedifferentiation. Cell Differentiation. Cell Lineage. Epithelial Cells / cytology. Neurons / cytology

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  • (PMID = 20939829.001).
  • [ISSN] 1095-8355
  • [Journal-full-title] Cell biology international
  • [ISO-abbreviation] Cell Biol. Int.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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27. Zhang C, Fu X, Chen P, Bao X, Li F, Sun X, Lei Y, Cai S, Sun T, Sheng Z: Dedifferentiation derived cells exhibit phenotypic and functional characteristics of epidermal stem cells. J Cell Mol Med; 2010 May;14(5):1135-45
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  • [Title] Dedifferentiation derived cells exhibit phenotypic and functional characteristics of epidermal stem cells.
  • Differentiated epidermal cells can dedifferentiate into stem cells or stem cell-like cells in vivo.
  • In this study, we report the isolation and characterization of dedifferentiation-derived cells.
  • Then we isolated these cells on the basis of rapid adhesion to type IV collagen and found that there were 4.56% adhering cells (dedifferentiation-derived cells) in the grafting group within 10 min.
  • The in vitro phenotypic assays showed that the expressions of CK19, beta1-integrin, Oct4 and Nanog in dedifferentiation-derived cells were remarkably higher than those in the control group (differentiated epidermal cells) (P < 0.01).
  • In addition, the results of the functional investigation of dedifferentiation-derived cells demonstrated:.
  • (2) more cells were in S phase and G2/M phase of the cell cycle (proliferation index values were 21.02% in control group, 45.08% in group of dedifferentiation);.
  • (3) the total days of culture (28 days versus 130 days), the passage number of cells (3 passages versus 20 passages) and assumptive total cell output (1 x 10(5) cells versus 1 x 10(12) cells) were all significantly increased and (4) dedifferentiation-derived cells, as well as epidermal stem cells, were capable of regenerating a skin equivalent, but differentiated epidermal cells could not.
  • These results suggested that the characteristics of dedifferentiation-derived cells cultured in vitro were similar to epidermal stem cells.
  • [MeSH-major] Cell Dedifferentiation. Epidermis / cytology. Stem Cells / cytology. Stem Cells / metabolism

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  • (PMID = 19426155.001).
  • [ISSN] 1582-4934
  • [Journal-full-title] Journal of cellular and molecular medicine
  • [ISO-abbreviation] J. Cell. Mol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD29; 0 / Biomarkers; 0 / Homeodomain Proteins; 0 / Keratin-19; 0 / NANOG protein, human; 0 / Octamer Transcription Factor-3; 0 / POU5F1 protein, human
  • [Other-IDs] NLM/ PMC3822750
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28. Lee JH, Yu SM, Yoon EK, Lee WK, Jung JC, Kim SJ: 15-deoxy-Delta 12,14-ProstaglandinJ2 regulates dedifferentiation through peroxisome proliferator-activated receptor-gamma-dependent pathway but not COX-2 expression in articular chondrocytes. J Korean Med Sci; 2007 Oct;22(5):891-7
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  • [Title] 15-deoxy-Delta 12,14-ProstaglandinJ2 regulates dedifferentiation through peroxisome proliferator-activated receptor-gamma-dependent pathway but not COX-2 expression in articular chondrocytes.
  • Peroxisome proliferator-activated receptors-gamma (PPAR-gamma) is critical for phenotype determination at early differentiation stages of mesenchymal cells, whereas its physiological role is unclear.
  • Therefore, we investigated the role of 15-deoxy-Delta(12,14)-prostaglandinJ2 (15d-PGJ2), the natural receptor ligand for PPAR-gamma, on dedifferentiation and inflammatory responses, such as COX-2 expression and PGE2 production, in articular chondrocytes.
  • Our data indicate that the 15d-PGJ2 caused a loss of differentiated chondrocyte phenotype as demonstrated by inhibition of type II collagen and proteoglycan synthesis.
  • The 15d-PGJ2-induced dedifferentiation effect seems to be dependent on PPAR-gamma activation, as the PPRE luciferase activity increased and PPAR-gamma antagonist, BADGE, abolished type II collagen expression.
  • Collectively, our findings suggest that PPAR-gamma-dependent and -independent mechanisms of 15d-PGJ2-induced dedifferentiation and inflammatory responses in articular chondrocytes, respectively.
  • [MeSH-minor] Animals. Cell Differentiation. Dinoprostone / metabolism. Dose-Response Relationship, Drug. Genes, Reporter. Immunoblotting. Rabbits. Time Factors. Transfection

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  • (PMID = 17982241.001).
  • [ISSN] 1011-8934
  • [Journal-full-title] Journal of Korean medical science
  • [ISO-abbreviation] J. Korean Med. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / 15-deoxy-delta(12,14)-prostaglandin J2; 0 / PPAR gamma; EC 1.14.99.1 / Cyclooxygenase 2; K7Q1JQR04M / Dinoprostone; RXY07S6CZ2 / Prostaglandin D2
  • [Other-IDs] NLM/ PMC2693859
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29. Périgny M, Dion N, Couture C, Lagacé R: [Low grade fibromyxoid sarcoma: a clinico-pathologic analysis of 7 cases]. Ann Pathol; 2006 Dec;26(6):419-25
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  • [Transliterated title] Sarcome fibromyxoïde de bas grade: une étude clinico-pathologique de 7 cas.
  • We describe the clinicopathologic features of 7 new cases of LGFMS including one case of dedifferentiation in a recurrence.
  • MATERIALS AND METHODS: 7 cases obtained from the surgical files of the CHUQ, L'Hôtel-Dieu de Québec or from the consultation files were studied.
  • One of them demonstrated an area of dedifferentiation into a high grade pleomorphic sarcoma, malignant fibrous histiocytoma (MFH) type.

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  • (PMID = 17255901.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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30. Derouiche A, El Attat R, Hentati H, Blah M, Slama A, Chebil M: Emphysematous pyelitis: epidemiological, therapeutic and evolutive features. Tunis Med; 2009 Mar;87(3):180-3
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  • Nephrectomy was done in one patient presenting a thinned -- dedifferentiated -- renal parenchyma.

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  • (PMID = 19537009.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Tunisia
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents
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31. Kim HJ, Archer E, Escobedo N, Tapscott SJ, Unguez GA: Inhibition of mammalian muscle differentiation by regeneration blastema extract of Sternopygus macrurus. Dev Dyn; 2008 Oct;237(10):2830-43
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  • [Title] Inhibition of mammalian muscle differentiation by regeneration blastema extract of Sternopygus macrurus.
  • Tissue regeneration through stem cell activation and/or cell dedifferentiation is widely distributed across the animal kingdom.
  • By comparison, regeneration in mammals is poor and this may reflect a limited dedifferentiation potential of mature cells.
  • Because mammalian myotubes can dedifferentiate in the presence of newt blastema extract, the present study tested the dedifferentiation induction capability of the blastema from the teleost Sternopygus macrurus (SmBE).
  • Furthermore, SmBE enhanced myoblast proliferation and reversibly inhibited their differentiation.
  • These data suggest the presence of protein factors in SmBE that regulate mammalian muscle physiology and differentiation, but do not support the conservation of a dedifferentiation induction capability by the blastema of S. macrurus.
  • [MeSH-major] Blastomeres. Cell Differentiation. Gymnotiformes. Muscles / cytology

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  • [Copyright] Copyright (c) 2008 Wiley-Liss, Inc.
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  • (PMID = 18816861.001).
  • [ISSN] 1058-8388
  • [Journal-full-title] Developmental dynamics : an official publication of the American Association of Anatomists
  • [ISO-abbreviation] Dev. Dyn.
  • [Language] eng
  • [Grant] United States / NIGMS NIH HHS / GM / R25 GM061222; United States / NCI NIH HHS / CA / U56 CA096286; United States / NIGMS NIH HHS / GM / GM007667-30S1; United States / NIGMS NIH HHS / GM / T34 GM007667; United States / NIGMS NIH HHS / GM / S06 GM008136-310053; United States / NCRR NIH HHS / RR / P20 RR016480-059004; United States / NIGMS NIH HHS / GM / R25GM061222; United States / NCI NIH HHS / CA / U54 CA132383; United States / NCI NIH HHS / CA / U56 CA096286-05; United States / NIGMS NIH HHS / GM / S06 GM008136; United States / NCI NIH HHS / CA / U56 CA096286-010003; United States / NIGMS NIH HHS / GM / S06-GM008136; United States / NCI NIH HHS / CA / U56-CA96286; United States / NCRR NIH HHS / RR / RR16480; United States / NCRR NIH HHS / RR / P20 RR016480
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Cell Extracts
  • [Other-IDs] NLM/ NIHMS96635; NLM/ PMC2651396
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32. Maki N, Tsonis PA, Agata K: Changes in global histone modifications during dedifferentiation in newt lens regeneration. Mol Vis; 2010 Sep 16;16:1893-7
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  • [Title] Changes in global histone modifications during dedifferentiation in newt lens regeneration.
  • After lens removal PECs in dorsal iris dedifferentiate and revert to stem cell-like cells, and transdifferentiate into lens cells.
  • The intensity of stained signal in nucleus of PECs was measured and changes in histone modification during dedifferentiation were evaluated.
  • RESULTS: During dedifferentiation of PECs histone modifications related to gene activation were differentially regulated.
  • Although tri-methylated histone H3 lysine 4 (TriMeH3K4) and acetylated histone H4 (AcH4) were increased, acetylated histone H3 lysine 9 (AcH3K9) was decreased during dedifferentiation.
  • Among all gene repression-related modifications analyzed only tri-methylated histone H3 lysine 27 (TriMeH3K27) showed a significant change.
  • CONCLUSIONS: Histone modifications are dynamically changed during dedifferentiation of PECs.
  • A coordination of gene activation-related modifications, increasing of TriMeH3K4 and AcH4 and decreasing of AcH3K9, as well as regulation of TriMeH3K27, could be a hallmark of chromatin regulation during newt dedifferentiation.

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  • (PMID = 21031136.001).
  • [ISSN] 1090-0535
  • [Journal-full-title] Molecular vision
  • [ISO-abbreviation] Mol. Vis.
  • [Language] ENG
  • [Grant] United States / NEI NIH HHS / EY / R01 EY010540; United States / NEI NIH HHS / EY / EY10540
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Histones
  • [Other-IDs] NLM/ PMC2956703
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33. Dufour C, Cadusseau J, Varlet P, Surena AL, de Faria GP, Dias-Morais A, Auger N, Léonard N, Daudigeos E, Dantas-Barbosa C, Grill J, Lazar V, Dessen P, Vassal G, Prevot V, Sharif A, Chneiweiss H, Junier MP: Astrocytes reverted to a neural progenitor-like state with transforming growth factor alpha are sensitized to cancerous transformation. Stem Cells; 2009 Oct;27(10):2373-82
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  • To determine whether TGF-alpha dedifferentiating effects are associated with cancerous transforming effects, we grafted intracerebrally dedifferentiated astrocytes.
  • When astrocytes dedifferentiated with TGF-alpha were submitted to oncogenic stress using gamma irradiation, they acquired cancerous properties: they were immortalized, showed cytogenomic abnormalities, and formed high-grade glioma-like tumors after brain grafting.
  • [MeSH-minor] Animals. Cell Dedifferentiation / drug effects. Cell Dedifferentiation / physiology. Cell Dedifferentiation / radiation effects. Cells, Cultured. Culture Media, Serum-Free / pharmacology. Gamma Rays / adverse effects. Mice. Mice, Inbred C57BL. Mice, Nude. Stem Cell Transplantation. Stress, Physiological / physiology. Stress, Physiological / radiation effects

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  • (PMID = 19544474.001).
  • [ISSN] 1549-4918
  • [Journal-full-title] Stem cells (Dayton, Ohio)
  • [ISO-abbreviation] Stem Cells
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Culture Media, Serum-Free; 0 / Transforming Growth Factor alpha
  • [Other-IDs] NLM/ HALMS439883; NLM/ PMC3245240
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34. Guo W, Li D, Tang X, Ji T: Surgical treatment of pelvic chondrosarcoma involving periacetabulum. J Surg Oncol; 2010 Feb 1;101(2):160-5
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  • There were 32 patients with conventional chondrosarcomas, 9 with dedifferentiated chondrosarcomas, and 4 with mesenchymal chondrosarcomas.

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  • (PMID = 19960486.001).
  • [ISSN] 1096-9098
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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35. Chen WJ, Pang JH, Lin KH, Lee DY, Hsu LA, Kuo CT: Propylthiouracil, independent of its antithyroid effect, promotes vascular smooth muscle cells differentiation via PTEN induction. Basic Res Cardiol; 2010 Jan;105(1):19-28
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  • [Title] Propylthiouracil, independent of its antithyroid effect, promotes vascular smooth muscle cells differentiation via PTEN induction.
  • In vitro, PTU may convert VSMCs from a serum-induced dedifferentiation state to a differentiated state, as indicated by a spindle-shaped morphology and an increase in the expression of SMC differentiation marker contractile proteins, including calponin and smooth muscle (SM)-myosin heavy chain (SM-MHC).
  • Propylthiouracil promotes VSMC differentiation, at lest in part, via induction of the PTEN-mediated pathway.
  • [MeSH-major] Antithyroid Agents / pharmacology. Carotid Artery, External / drug effects. Cell Differentiation / drug effects. Myocytes, Smooth Muscle / drug effects. Propylthiouracil / pharmacology

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  • (PMID = 19633808.001).
  • [ISSN] 1435-1803
  • [Journal-full-title] Basic research in cardiology
  • [ISO-abbreviation] Basic Res. Cardiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antithyroid Agents; 0 / Contractile Proteins; 721M9407IY / Propylthiouracil; EC 3.1.3.48 / Pten protein, rat; EC 3.1.3.67 / PTEN Phosphohydrolase
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36. Bekeredjian-Ding I, Doster A, Schiller M, Heyder P, Lorenz HM, Schraven B, Bommhardt U, Heeg K: TLR9-activating DNA up-regulates ZAP70 via sustained PKB induction in IgM+ B cells. J Immunol; 2008 Dec 15;181(12):8267-77
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  • In the past, ZAP70 was considered a T cell-specific kinase, and its aberrant expression in B-CLL cells was interpreted as a sign of malignant transformation and dedifferentiation.


37. Kanda Y, Hisayasu S, Fukai F, Takase B: Milk growth factor (MGF) induces transformation into ATDC5 cells, prechondrocytes, and cooperates with retinoic acid to transform the cells into new forms. Life Sci; 2006 Jan 2;78(6):640-8
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  • The synthesis of vimentin in ATDC5 cells was slightly induced by RA, but its withdrawal induced the large-scale induction and the fibril formation of vimentin, which may indicate that the cells became fibroblastic cells, namely dedifferentiation.
  • [MeSH-major] Cell Differentiation / drug effects. Chondrocytes / drug effects. Stem Cells / drug effects. Transforming Growth Factor beta / pharmacology. Tretinoin / pharmacology

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  • (PMID = 16111716.001).
  • [ISSN] 0024-3205
  • [Journal-full-title] Life sciences
  • [ISO-abbreviation] Life Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Actins; 0 / Proteoglycans; 0 / Transforming Growth Factor beta; 0 / Vimentin; 5688UTC01R / Tretinoin
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38. Romei C, Ciampi R, Faviana P, Agate L, Molinaro E, Bottici V, Basolo F, Miccoli P, Pacini F, Pinchera A, Elisei R: BRAFV600E mutation, but not RET/PTC rearrangements, is correlated with a lower expression of both thyroperoxidase and sodium iodide symporter genes in papillary thyroid cancer. Endocr Relat Cancer; 2008 Jun;15(2):511-20
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  • In the present study, we analyzed the mRNA expression of thyroid differentiation genes, glucose transporter (GLUT)-1 and GLUT-3, in 78 PTCs according to the presence of BRAFV600E or RET/PTC rearrangements.
  • In contrast, no difference either in NIS or in any other thyroid differentiation genes' mRNA expression was found in PTC with or without RET/PTC rearrangements.
  • This latter finding could indicate that an early dedifferentiation process is present at the molecular level in BRAFV600E-mutated PTC, thus suggesting that the previously demonstrated poor prognostic significance of BRAFV600E mutation could be related to the dedifferentiation process more than to a more advanced stage at diagnosis.
  • [MeSH-minor] Adult. Cell Differentiation. Female. Gene Expression Regulation, Neoplastic. Gene Rearrangement. Glucose Transporter Type 1 / genetics. Glucose Transporter Type 3 / genetics. Humans. Immunohistochemistry. Male. Point Mutation. RNA, Messenger / metabolism. Thyrotropin / blood

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  • (PMID = 18509003.001).
  • [ISSN] 1351-0088
  • [Journal-full-title] Endocrine-related cancer
  • [ISO-abbreviation] Endocr. Relat. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Autoantigens; 0 / Glucose Transporter Type 1; 0 / Glucose Transporter Type 3; 0 / Iron-Binding Proteins; 0 / RNA, Messenger; 0 / SLC2A1 protein, human; 0 / SLC2A3 protein, human; 0 / Symporters; 0 / sodium-iodide symporter; 9002-71-5 / Thyrotropin; EC 1.11.1.7 / TPO protein, human; EC 1.11.1.8 / Iodide Peroxidase; EC 2.7.10.1 / Proto-Oncogene Proteins c-ret; EC 2.7.10.1 / RET protein, human; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf
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39. Balen B, Krsnik-Rasol M, Zamfir AD, Milosević J, Vakhrushev SY, Peter-Katalinić J: Glycoproteomic survey of Mammillaria gracillis tissues grown in vitro. J Proteome Res; 2006 Jul;5(7):1658-66
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  • However, little information about the glycoprotein patterns related to plant cell differentiation, dedifferentiation and transformation is available.

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  • (PMID = 16823973.001).
  • [ISSN] 1535-3893
  • [Journal-full-title] Journal of proteome research
  • [ISO-abbreviation] J. Proteome Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Glycoproteins; 0 / Plant Proteins
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40. Ali ST, Mahmooduzzafar, Abdin MZ, Iqbal M: Ontogenetic changes in foliar features and psoralen content of Psoralea corylifolia Linn. exposed to SO2 stress. J Environ Biol; 2008 Sep;29(5):661-8
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  • Interestingly new epidermis developed oversome of the damaged leaf stomata, thus showing a unique defence strategy against SO2 stress through dedifferentiation of the epidermal cells.
  • [MeSH-minor] Carotenoids / metabolism. Cell Differentiation / drug effects. Chlorophyll / metabolism. Photosynthesis / drug effects. Plant Leaves / anatomy & histology. Plant Leaves / drug effects. Plant Leaves / physiology. Plant Stomata / drug effects. Plant Stomata / ultrastructure

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  • (PMID = 19295061.001).
  • [ISSN] 0254-8704
  • [Journal-full-title] Journal of environmental biology
  • [ISO-abbreviation] J Environ Biol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] India
  • [Chemical-registry-number] 0UZA3422Q4 / Sulfur Dioxide; 1406-65-1 / Chlorophyll; 36-88-4 / Carotenoids; KTZ7ZCN2EX / Ficusin
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41. Walter MA, Wild D, Rasch H, Müller-Brand J, Müller B, Bilz S: Coregistered iodine-131 single photon emission computed tomography/computed tomography reveals dedifferentiation in a metastatic follicular thyroid carcinoma. Thyroid; 2006 Oct;16(10):1063-4
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  • [Title] Coregistered iodine-131 single photon emission computed tomography/computed tomography reveals dedifferentiation in a metastatic follicular thyroid carcinoma.

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  • (PMID = 17042695.001).
  • [ISSN] 1557-9077
  • [Journal-full-title] Thyroid : official journal of the American Thyroid Association
  • [ISO-abbreviation] Thyroid
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Iodine Radioisotopes
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42. Sauvant C, Schneider R, Holzinger H, Renker S, Wanner C, Gekle M: Implementation of an in vitro model system for investigation of reperfusion damage after renal ischemia. Cell Physiol Biochem; 2009;24(5-6):567-76
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  • Namely, induction of necrosis, apoptosis and of ischemia reperfusion induced protein (IRIP), dedifferentiation (alphaSMA), inflammation (MCP-1), inducible NO-synthase (iNOS), release of PGE(2) and basolateral uptake of organic anions.

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  • [Copyright] 2009 S. Karger AG, Basel.
  • (PMID = 19910697.001).
  • [ISSN] 1421-9778
  • [Journal-full-title] Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
  • [ISO-abbreviation] Cell. Physiol. Biochem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Actins; 0 / Ccl2 protein, rat; 0 / Chemokine CCL2; EC 1.14.13.39 / Nitric Oxide Synthase Type II; K7Q1JQR04M / Dinoprostone
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43. Chang KT, Huang CY, Tsai CM, Chiu CH, Lok YY: Role of IL-6 in neuroendocrine differentiation and chemosensitivity of non-small cell lung cancer. Am J Physiol Lung Cell Mol Physiol; 2005 Sep;289(3):L438-45
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  • [Title] Role of IL-6 in neuroendocrine differentiation and chemosensitivity of non-small cell lung cancer.
  • Interleukin-6 (IL-6) has been shown to regulate both growth and neuroendocrine (NE) differentiation in some types of human cancer cells, and erbB2 may be a critical component of IL-6 signaling.
  • We investigated whether IL-6 is implicated in the cell growth, NE differentiation, and chemosensitivity of NSCLC-NE cells.
  • These cells were assessed for cell proliferation by cell counting and 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assays, chemosensitivity to cisplatin and etoposide by MTT assays, and NE differentiation by observing morphological changes and immunoblotting for neuron-specific enolase (NSE).
  • The IL-6-treated cells and the IL-6-transfected cells showed enhanced cell proliferation and downregulated NSE expression, but little change in chemosensitivity.
  • In conclusion, IL-6 can induce cell proliferation and NE dedifferentiation but has little effect on chemosensitivity in IL-6 receptor-expressing NSCLC-NE cells.
  • [MeSH-minor] Antineoplastic Agents, Phytogenic / pharmacology. Cell Count. Cell Differentiation / drug effects. Cell Division / drug effects. Cell Line, Tumor. Cisplatin / pharmacology. Coloring Agents. Down-Regulation. Etoposide / pharmacology. Humans. Phosphopyruvate Hydratase / metabolism. Receptor, Epidermal Growth Factor / metabolism. Receptors, Interleukin-6 / metabolism. Recombinant Proteins / pharmacology. Signal Transduction. Tetrazolium Salts. Thiazoles


44. Taguchi S, Shono T, Mori D, Horie H: Extrarenal Wilms tumor in children with unfavorable histology: a case report. J Pediatr Surg; 2010 Sep;45(9):e19-22
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  • Pathologic diagnosis of the tumor was extrarenal Wilms tumor with diffuse anaplasia.

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20850611.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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45. Lam KY, Lo CY, Wei WI: Warthin tumor-like variant of papillary thyroid carcinoma: a case with dedifferentiation (anaplastic changes) and aggressive biological behavior. Endocr Pathol; 2005;16(1):83-9
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  • [Title] Warthin tumor-like variant of papillary thyroid carcinoma: a case with dedifferentiation (anaplastic changes) and aggressive biological behavior.
  • In this report, a Warthin tumor-like variant of the papillary thyroid carcinoma, 5-cm in maximum dimension, underwent anaplastic changes in a 74-yr-old woman.
  • The tumor was positive for CD15 and EMA, and a high proliferative index was noted in the anaplastic area.
  • The patient developed distant metastases after operation and died of the disease 18 mo after the operation.
  • The present case is the first reported case of Warthin tumor-like variant of papillary thyroid carcinoma with anaplastic changes.

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  • (PMID = 16000851.001).
  • [ISSN] 1046-3976
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD15; 0 / Biomarkers, Tumor; 0 / Mucin-1
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46. Knauf JA, Ma X, Smith EP, Zhang L, Mitsutake N, Liao XH, Refetoff S, Nikiforov YE, Fagin JA: Targeted expression of BRAFV600E in thyroid cells of transgenic mice results in papillary thyroid cancers that undergo dedifferentiation. Cancer Res; 2005 May 15;65(10):4238-45
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  • [Title] Targeted expression of BRAFV600E in thyroid cells of transgenic mice results in papillary thyroid cancers that undergo dedifferentiation.
  • BRAFT1799A is found with high prevalence in tall-cell variant PTCs and in poorly differentiated and undifferentiated carcinomas arising from PTCs.
  • In Tg-BRAF2 mice, PTCs were present at 12 and 22 weeks in 14 of 15 and 13 of 14 animals, respectively, with 83% exhibiting tall-cell features, 83% areas of invasion, and 48% foci of poorly differentiated carcinoma.
  • In summary, thyroid-specific expression of BRAFV600E induces goiter and invasive PTC, which transitions to poorly differentiated carcinomas.


47. Rugge M, Fassan M, Zaninotto G, Pizzi M, Giacomelli L, Battaglia G, Rizzetto C, Parente P, Ancona E: Aurora kinase A in Barrett's carcinogenesis. Hum Pathol; 2010 Oct;41(10):1380-6
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  • AURKA immunostaining increased progressively and significantly along with dedifferentiation of the histologic phenotype (P < .001).

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20656315.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53; EC 2.7.11.1 / AURKA protein, human; EC 2.7.11.1 / Aurora Kinase A; EC 2.7.11.1 / Aurora Kinases; EC 2.7.11.1 / Protein-Serine-Threonine Kinases
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48. Campos LM, Cavalcanti CL, Lima-Filho JL, Carvalho LB, Beltrão EI: Acridinium ester conjugated to lectin as chemiluminescent histochemistry marker. Biomarkers; 2006 Sep-Oct;11(5):480-4
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  • Cell differentiation/dedifferentiation includes changes in oligosaccharide composition and distribution in the cell surface glycoconjugates.

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  • (PMID = 16966164.001).
  • [ISSN] 1354-750X
  • [Journal-full-title] Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
  • [ISO-abbreviation] Biomarkers
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Acridines; 0 / Biomarkers, Tumor; 0 / Lectins
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49. Ju W, Ogawa A, Heyer J, Nierhof D, Yu L, Kucherlapati R, Shafritz DA, Böttinger EP: Deletion of Smad2 in mouse liver reveals novel functions in hepatocyte growth and differentiation. Mol Cell Biol; 2006 Jan;26(2):654-67
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  • [Title] Deletion of Smad2 in mouse liver reveals novel functions in hepatocyte growth and differentiation.
  • Collectively, these results demonstrate that Smad2 suppresses hepatocyte growth and dedifferentiation independent of TGF-beta signaling.

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  • (PMID = 16382155.001).
  • [ISSN] 0270-7306
  • [Journal-full-title] Molecular and cellular biology
  • [ISO-abbreviation] Mol. Cell. Biol.
  • [Language] ENG
  • [Grant] United States / NIH HHS / OD / P5ODK064236-01003; United States / NIDDK NIH HHS / DK / R01 DK056077; United States / NIDDK NIH HHS / DK / U01 DK060995; United States / NIDDK NIH HHS / DK / P30 DK041296; United States / NIDDK NIH HHS / DK / R01DK60043; United States / NIDDK NIH HHS / DK / R01 DK073960; United States / NIDDK NIH HHS / DK / 2P30DK041296-16; United States / NIDDK NIH HHS / DK / R01 DK060043; United States / NIDDK NIH HHS / DK / R01DK56077; United States / NCI NIH HHS / CA / R24 CA095823
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Smad2 Protein; 0 / Smad3 Protein; 0 / Transforming Growth Factor beta; 136601-57-5 / Cyclin D1
  • [Other-IDs] NLM/ PMC1346892
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50. Heebøll S, Borre M, Ottosen PD, Dyrskjøt L, Orntoft TF, Tørring N: Snail1 is over-expressed in prostate cancer. APMIS; 2009 Mar;117(3):196-204
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  • Snail1 expression was significantly increased in PC with a positive correlation to dedifferentiation, but not to cancer progression or prognosis.
  • [MeSH-minor] Cell Nucleus / metabolism. Disease Progression. Humans. Immunohistochemistry. Lymphatic Metastasis. Male. Up-Regulation

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  • (PMID = 19245592.001).
  • [ISSN] 1600-0463
  • [Journal-full-title] APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
  • [ISO-abbreviation] APMIS
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Transcription Factors; 0 / snail family transcription factors
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51. Tholpady SS, Aojanepong C, Llull R, Jeong JH, Mason AC, Futrell JW, Ogle RC, Katz AJ: The cellular plasticity of human adipocytes. Ann Plast Surg; 2005 Jun;54(6):651-6
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  • We hypothesize that these histologic changes reflect a dedifferentiation of ischemic mature adipocytes instead of, or in addition to, a more traditional response.
  • To explore this hypothesis, we studied the in vitro morphologic changes of cultured mature human adipocytes isolated from liposuctioned adipose tissue.
  • Adipogenic induction of such dedifferentiated adipocytes resulted in reaccumulation of intracellular lipid.
  • This study demonstrates that mature adipocytes can be cultured from human liposuctioned fat, they can dedifferentiate into fibroblastic cells, and the fibroblast-like cells can be expanded and turned into lipid-synthesizing adipocytes.
  • [MeSH-minor] Adult. Cell Differentiation. Cells, Cultured. Humans

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  • (PMID = 15900154.001).
  • [ISSN] 0148-7043
  • [Journal-full-title] Annals of plastic surgery
  • [ISO-abbreviation] Ann Plast Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 23
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52. Maki N, Martinson J, Nishimura O, Tarui H, Meller J, Tsonis PA, Agata K: Expression profiles during dedifferentiation in newt lens regeneration revealed by expressed sequence tags. Mol Vis; 2010 Jan 18;16:72-8
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  • [Title] Expression profiles during dedifferentiation in newt lens regeneration revealed by expressed sequence tags.
  • PURPOSE: The adult newt can regenerate lens from pigmented epithelial cells (PECs) of the dorsal iris via dedifferentiation.
  • The purpose of this research is to obtain sequence resources for a newt lens regeneration study and to obtain insights of dedifferentiation at the molecular level.
  • METHODS: mRNA was purified from iris during dedifferentiation and its cDNA library was constructed.
  • The presence of several cancer- and apoptosis-related genes during newt dedifferentiation was revealed.
  • Moreover, several candidate genes, which might participate in reprogramming during dedifferentiation, were also found.
  • CONCLUSIONS: The expression of cancer- and apoptosis-related genes could be hallmarks during dedifferentiation.
  • The expression sequence tag (EST) resource is useful for the future study of newt dedifferentiation, and the sequence information is available in GenBank (accession numbers; FS290155-FS300559).

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  • (PMID = 20090923.001).
  • [ISSN] 1090-0535
  • [Journal-full-title] Molecular vision
  • [ISO-abbreviation] Mol. Vis.
  • [Language] ENG
  • [Grant] United States / NIEHS NIH HHS / ES / P30 ES006096; United States / NEI NIH HHS / EY / R01 EY010540; United States / NEI NIH HHS / EY / EY10540; United States / NIEHS NIH HHS / ES / P30-ES006096
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2807617
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53. Weishaupt JH, Klöcker N, Bähr M: Axotomy-induced early down-regulation of POU-IV class transcription factors Brn-3a and Brn-3b in retinal ganglion cells. J Mol Neurosci; 2005;26(1):17-25
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  • It has been proposed that neurons being exposed to proapoptotic stimuli undergo dedifferentiation, a process that can either allow for regeneration and axon regrowth or, if remaining incomplete, can force the cell to activate apoptotic pathways.
  • A pivotal step in the differentiation program from neuronal precursor cells to differentiated, postmitotic neurons is their exit from the cell cycle.
  • The POU domain transcription factors Brn-3b and Brn-3a, which are expressed in retinal ganglion cells (RGCs) directly after the exit of RGC precursors from the cell cycle, can be employed as RGC-specific differentiation markers to study potential dedifferentiation of RGCs after axotomy.
  • Here, we examined mRNAand protein expression of Brn-3a and -3b in rat RGCs following axonal lesion.
  • In conclusion, we found further evidence supporting the hypothesis of a dedifferentiation process in severed mature neurons.

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  • (PMID = 15968082.001).
  • [ISSN] 0895-8696
  • [Journal-full-title] Journal of molecular neuroscience : MN
  • [ISO-abbreviation] J. Mol. Neurosci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / Transcription Factor Brn-3; 0 / Transcription Factor Brn-3B; 0 / Transcription Factors
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54. Li WC, Rukstalis JM, Nishimura W, Tchipashvili V, Habener JF, Sharma A, Bonner-Weir S: Activation of pancreatic-duct-derived progenitor cells during pancreas regeneration in adult rats. J Cell Sci; 2010 Aug 15;123(Pt 16):2792-802
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  • We hypothesized that after partial pancreatectomy (Px) in adult rats, pancreatic-duct cells serve as a source of regeneration by undergoing a reproducible dedifferentiation and redifferentiation.
  • We support this hypothesis by the detection of an early loss of the ductal differentiation marker Hnf6 in the mature ducts, followed by the transient appearance of areas composed of proliferating ductules, called foci of regeneration, which subsequently form new pancreatic lobes.
  • Taken together, we provide a mechanism by which adult pancreatic duct cells recapitulate aspects of embryonic pancreas differentiation in response to injury, and contribute to regeneration of the pancreas.
  • This mechanism of regeneration relies mainly on the plasticity of the differentiated cells within the pancreas.

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  • (PMID = 20663919.001).
  • [ISSN] 1477-9137
  • [Journal-full-title] Journal of cell science
  • [ISO-abbreviation] J. Cell. Sci.
  • [Language] ENG
  • [Grant] United States / NCRR NIH HHS / RR / S10 RR025065; United States / NIDDK NIH HHS / DK / R01 DK 66056; United States / NIDDK NIH HHS / DK / P30 DK36836; United States / NIDDK NIH HHS / DK / P30 DK036836; United States / NIDDK NIH HHS / DK / R01 DK066056; United States / NIDDK NIH HHS / DK / K01 DK076791
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Basic Helix-Loop-Helix Transcription Factors; 0 / Hepatocyte Nuclear Factor 6; 0 / Nerve Tissue Proteins; 0 / Neurog3 protein, rat; 0 / Onecut1 protein, rat; 0 / Transcription Factors
  • [Other-IDs] NLM/ PMC2915881
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55. Hayashi K, Surani MA: Self-renewing epiblast stem cells exhibit continual delineation of germ cells with epigenetic reprogramming in vitro. Development; 2009 Nov;136(21):3549-56
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  • Notably, the PGCs can, in turn, be induced to undergo dedifferentiation into pluripotent embryonic germ cells (EGCs), which resemble ESCs and not the EpiSC from which they are derived.


56. Xing Y, Li C, Hu L, Tiozzo C, Li M, Chai Y, Bellusci S, Anderson S, Minoo P: Mechanisms of TGFbeta inhibition of LUNG endodermal morphogenesis: the role of TbetaRII, Smads, Nkx2.1 and Pten. Dev Biol; 2008 Aug 15;320(2):340-50
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  • Transforming growth factor-beta is a multifunctional growth factor with roles in normal development and disease pathogenesis.
  • Inhibition of morphogenesis was associated with dedifferentiation of endodermal cells as documented by a decrease in key transcriptional factor, NKX2.1 protein, and its downstream target, surfactant protein C (SpC).

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  • (PMID = 18602626.001).
  • [ISSN] 1095-564X
  • [Journal-full-title] Developmental biology
  • [ISO-abbreviation] Dev. Biol.
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / HL073471-01A1; United States / NHLBI NIH HHS / HL / R01 HL073471-01A1; United States / NHLBI NIH HHS / HL / HL056590-12; United States / NHLBI NIH HHS / HL / R01 HL073471; United States / NHLBI NIH HHS / HL / R01 HL107307; United States / NHLBI NIH HHS / HL / R01 HL056590; United States / NHLBI NIH HHS / HL / R01 HL056590-12
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Nuclear Proteins; 0 / Receptors, Transforming Growth Factor beta; 0 / Smad Proteins, Receptor-Regulated; 0 / Smad3 Protein; 0 / Smad4 Protein; 0 / TGFB1 protein, human; 0 / Transcription Factors; 0 / Transforming Growth Factor beta1; 0 / thyroid nuclear factor 1; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; EC 2.7.11.30 / transforming growth factor-beta type II receptor; EC 3.1.3.48 / Pten protein, mouse; EC 3.1.3.67 / PTEN Phosphohydrolase
  • [Other-IDs] NLM/ NIHMS65745; NLM/ PMC2597224
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57. Mathur M, Samuels HH: Role of PSF-TFE3 oncoprotein in the development of papillary renal cell carcinomas. Oncogene; 2007 Jan 11;26(2):277-83
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  • In addition, the expression of PSF-TFE3 in normal renal proximal tubular epithelial cells from where such tumors originate leads to dedifferentiation and loss of some key functional proteins, which may reflect an initial step in the multistep process of tumor development.

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  • (PMID = 16832349.001).
  • [ISSN] 0950-9232
  • [Journal-full-title] Oncogene
  • [ISO-abbreviation] Oncogene
  • [Language] eng
  • [Grant] United States / NIAMS NIH HHS / AR / AR02083; United States / NIDDK NIH HHS / DK / DK16636
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; 0 / Oncogene Proteins, Fusion; 0 / PTB-associated splicing factor; 0 / RNA, Small Interfering; 0 / RNA-Binding Proteins; 0 / TFE3 protein, human
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58. Kono T, Imai Y, Imura J, Ono Y, Hagiwara S, Taira K, Fujita M, Tsubaki M, Sunagawa M, Fujimori T: Cecal adenocarcinoma with prominent rhabdoid feature: report of a case with immunohistochemical, ultrastructural, and molecular analyses. Int J Surg Pathol; 2007 Oct;15(4):414-20
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  • Colorectal adenocarcinoma with rhabdoid phenotype is extremely rare, and only 1 case of adenocarcinoma showing rhabdoid dedifferentiation has been reported.
  • These results suggested that the rhabdoid cells were dedifferentiated adenocarcinoma.

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  • (PMID = 17913953.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Biomarkers, Tumor; 0 / MLH1 protein, human; 0 / Nuclear Proteins; 0 / Vimentin; 68238-35-7 / Keratins
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59. Maeshima AM, Taniguchi H, Nomoto J, Maruyama D, Kim SW, Watanabe T, Kobayashi Y, Tobinai K, Matsuno Y: Histological and immunophenotypic changes in 59 cases of B-cell non-Hodgkin's lymphoma after rituximab therapy. Cancer Sci; 2009 Jan;100(1):54-61
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  • Sixteen cases (27%) showed loss of CD20 expression with four histological patterns: pattern 1, no remarkable histological change (FL, 5; DLBCL, 3; and CLL, 2); pattern 2, proliferation of plasmacytoid cells (FL, 2; DLBCL, 1; and MZBCL, 1); pattern 3, transformation to classical Hodgkin's lymphoma (FL, 1); and pattern 4, transformation to anaplastic large cell lymphoma-like undifferentiated lymphoma (FL, 1).

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  • (PMID = 19038008.001).
  • [ISSN] 1349-7006
  • [Journal-full-title] Cancer science
  • [ISO-abbreviation] Cancer Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antigens, CD20; 0 / Antineoplastic Agents; 4F4X42SYQ6 / Rituximab
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60. Kim YH, Lee JW: Targeting of focal adhesion kinase by small interfering RNAs reduces chondrocyte redifferentiation capacity in alginate beads culture with type II collagen. J Cell Physiol; 2009 Mar;218(3):623-30
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  • In this study, we focused on phosphorylation of FAK and MAP kinase in chondrocyte-type II collagen interaction and dedifferentiation, and the effects of FAK knockdown on chondrocyte-specific gene expression and cell proliferation were determined.
  • In contrast, expression levels of p-FAK(Y397) and p-ERK1/2, but not p-Smad2/3, were decreased in dedifferentiated chondrocytes with loss of type II collagen expression.
  • Type II collagen expression was significantly increased when dedifferentiated chondrocytes were transferred to alginate beads with TGF-beta1 or type II collagen, but transfected cells with small interfering RNA for FAK (FAK-siRNA) inhibited mRNA expression of type II collagen and SOX-6 compared to the control.
  • [MeSH-major] Alginates / metabolism. Cell Differentiation. Chondrocytes / cytology. Chondrocytes / enzymology. Collagen Type II / metabolism. Focal Adhesion Protein-Tyrosine Kinases / metabolism. RNA, Small Interfering / metabolism
  • [MeSH-minor] Adult. Animals. Cell Culture Techniques. Cell Dedifferentiation. Cell Proliferation. Cell Shape. Enzyme Activation. Extracellular Signal-Regulated MAP Kinases / metabolism. Gene Expression Regulation. Glucuronic Acid / metabolism. Glycosaminoglycans / metabolism. Hexuronic Acids / metabolism. Humans. Microspheres. Middle Aged. Phosphorylation. Smad Proteins / metabolism. Swine

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  • (PMID = 19006177.001).
  • [ISSN] 1097-4652
  • [Journal-full-title] Journal of cellular physiology
  • [ISO-abbreviation] J. Cell. Physiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Alginates; 0 / Collagen Type II; 0 / Glycosaminoglycans; 0 / Hexuronic Acids; 0 / RNA, Small Interfering; 0 / Smad Proteins; 8A5D83Q4RW / Glucuronic Acid; 8C3Z4148WZ / alginic acid; EC 2.7.10.2 / Focal Adhesion Protein-Tyrosine Kinases; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases
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61. Lind P, Kohlfürst S: Respective roles of thyroglobulin, radioiodine imaging, and positron emission tomography in the assessment of thyroid cancer. Semin Nucl Med; 2006 Jul;36(3):194-205
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  • An increase of thyroglobulin over time is suspicious for recurrent or metastatic disease.
  • Especially in high-risk patients, aside from the use of ultrasonography for the detection of local recurrence and cervial lymph node metastases, nuclear medicine methods such as radioiodine imaging and FDG-PET are the methods of choice for localizing metastatic disease.
  • Radioiodine imaging detects well-differentiated recurrences and metastases with a high specificity but only moderate sensitivity.
  • In patients with low or dedifferentiated thyroid cancer and after several courses of radioiodine therapy caused by metastatic disease, iodine negative metastases may develop.
  • The fusion of the metabolic and morphologic information was able to increase the diagnostic accuracy, reduces pitfalls and changes therapeutic strategies in a reasonable number of patients.

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  • (PMID = 16762610.001).
  • [ISSN] 0001-2998
  • [Journal-full-title] Seminars in nuclear medicine
  • [ISO-abbreviation] Semin Nucl Med
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Iodine Radioisotopes; 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18; 9002-71-5 / Thyrotropin; 9010-34-8 / Thyroglobulin
  • [Number-of-references] 82
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62. Ambrosini G, Sambol EB, Carvajal D, Vassilev LT, Singer S, Schwartz GK: Mouse double minute antagonist Nutlin-3a enhances chemotherapy-induced apoptosis in cancer cells with mutant p53 by activating E2F1. Oncogene; 2007 May 24;26(24):3473-81
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  • In the human dedifferentiated liposarcoma cell line (LS141) and the p53 wild-type HCT116 cells, Nutlin-3a induced downregulation of E2F1 and this effect appeared to be proteasome dependent.

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  • (PMID = 17146434.001).
  • [ISSN] 0950-9232
  • [Journal-full-title] Oncogene
  • [ISO-abbreviation] Oncogene
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / DNA-Binding Proteins; 0 / E2F1 Transcription Factor; 0 / E2f1 protein, mouse; 0 / Imidazoles; 0 / Nuclear Proteins; 0 / PMAIP1 protein, human; 0 / Piperazines; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Tumor Suppressor Protein p53; 0 / Tumor Suppressor Proteins; 0 / nutlin 3; 0 / tumor suppressor protein p73; 80168379AG / Doxorubicin; BG3F62OND5 / Carboplatin; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2; Q20Q21Q62J / Cisplatin
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63. Shamberger RC, Haase GM, Argani P, Perlman EJ, Cotton CA, Takashima J, Green DM, Ritchey ML: Bilateral Wilms' tumors with progressive or nonresponsive disease. J Pediatr Surg; 2006 Apr;41(4):652-7; discussion 652-7
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  • [Title] Bilateral Wilms' tumors with progressive or nonresponsive disease.
  • BACKGROUND: To provide guidelines for future cooperative group trials, we reviewed the outcomes of children with bilateral Wilms' tumors (BWTs) treated on National Wilms Tumor Study-4 (NWTS-4) who had progressive or nonresponsive disease (PNRD).
  • Pathology at resection revealed previously undiagnosed anaplasia in 3 patients (2 diffuse and 1 focal) treated for 14, 15, and 15 months before resection.
  • A fourth patient developed a diffusely anaplastic tumor 13 months after therapy.
  • Other pathological findings included rhabdomyomatous (4 patients) or differentiated stromal elements (10 patients) and complete necrosis (1 patient).
  • This will identify anaplastic tumors managed best by early nephrectomy and intensive chemotherapy and will also distinguish differentiated tumors that are best managed with early resection, but less intensive therapy after nephrectomy.
  • [MeSH-minor] Chemotherapy, Adjuvant. Child. Disease Progression. Humans. Treatment Failure

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  • (PMID = 16567171.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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64. Varkonyi J, Karádi I, Szocs K, Sugár I, Sápi Z, Marschalko M, Pállinger E, Darvas Z, Falus A: Loss of histidine decarboxylase as a marker of malignant transformation and dedifferentiation of B-cells infiltrating the skin. A case report of a therapy-resistant multiple myeloma complicated by skin infiltration. Acta Oncol; 2008;47(3):458-61
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  • [Title] Loss of histidine decarboxylase as a marker of malignant transformation and dedifferentiation of B-cells infiltrating the skin. A case report of a therapy-resistant multiple myeloma complicated by skin infiltration.
  • [MeSH-minor] Aged. Bone Marrow / pathology. Cell Dedifferentiation. Cell Transformation, Neoplastic. Fatal Outcome. Female. Histamine / metabolism. Humans. Plasma Cells / enzymology. Plasma Cells / pathology. Syndecan-1 / analysis

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  • (PMID = 17851872.001).
  • [ISSN] 1651-226X
  • [Journal-full-title] Acta oncologica (Stockholm, Sweden)
  • [ISO-abbreviation] Acta Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Norway
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; 0 / SDC1 protein, human; 0 / Syndecan-1; 820484N8I3 / Histamine; EC 4.1.1.22 / Histidine Decarboxylase
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65. Jumabay M, Matsumoto T, Yokoyama S, Kano K, Kusumi Y, Masuko T, Mitsumata M, Saito S, Hirayama A, Mugishima H, Fukuda N: Dedifferentiated fat cells convert to cardiomyocyte phenotype and repair infarcted cardiac tissue in rats. J Mol Cell Cardiol; 2009 Nov;47(5):565-75
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  • [Title] Dedifferentiated fat cells convert to cardiomyocyte phenotype and repair infarcted cardiac tissue in rats.
  • Adipose tissue-derived stem cells have been demonstrated to differentiate into cardiomyocytes and vascular endothelial cells.
  • Here we investigate whether mature adipocyte-derived dedifferentiated fat (DFAT) cells can differentiate to cardiomyocytes in vitro and in vivo by establishing DFAT cell lines via ceiling culture of mature adipocytes.
  • DFAT cells were obtained by dedifferentiation of mature adipocytes from GFP-transgenic rats.
  • We evaluated the differentiating ability of DFAT cells into cardiomyocytes by detection of the cardiac phenotype markers in immunocytochemical and RT-PCR analyses in vitro.
  • DFAT cells expressed cardiac phenotype markers when cocultured with cardiomyocytes and also when grown in MethoCult medium in the absence of cardiomyocytes, indicating that DFAT cells have the potential to differentiate to cardiomyocyte lineage.
  • We demonstrated that DFAT cells have the ability to differentiate to cardiomyocyte-like cells in vitro and in vivo.
  • We propose that DFAT cells represent a promising candidate cell source for cardiomyocyte regeneration in severe ischemic heart disease.
  • [MeSH-major] Adipocytes / cytology. Cell Dedifferentiation / physiology. Myocardial Infarction / therapy. Myocytes, Cardiac / cytology
  • [MeSH-minor] Animals. Cell Transplantation. Cells, Cultured. Disease Models, Animal. Immunohistochemistry. Male. Neovascularization, Physiologic / physiology. Rats. Rats, Sprague-Dawley. Rats, Transgenic. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 19686758.001).
  • [ISSN] 1095-8584
  • [Journal-full-title] Journal of molecular and cellular cardiology
  • [ISO-abbreviation] J. Mol. Cell. Cardiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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66. Kaliaperumal C, Suttner N, Herron B, Choudhari KA: Rare case of primary spinal ependymomatosis occurring in a 26-year-old man: a case report. J Med Case Rep; 2009;3:72
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  • Multiple primary ependymomatous lesions were seen on magnetic resonance imaging and no anaplasia was identified on the surgical-pathological analysis.

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  • (PMID = 19946548.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
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  • [Publication-type] Journal Article
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67. Bramsiepe J, Wester K, Weinl C, Roodbarkelari F, Kasili R, Larkin JC, Hülskamp M, Schnittger A: Endoreplication controls cell fate maintenance. PLoS Genet; 2010 Jun 24;6(6):e1000996
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  • Cell-fate specification is typically thought to precede and determine cell-cycle regulation during differentiation.
  • Here we show that endoreplication, also known as endoreduplication, a specialized cell-cycle variant often associated with cell differentiation but also frequently occurring in malignant cells, plays a role in maintaining cell fate.
  • Live observations of young Arabidopsis leaves revealed that dedifferentiating trichomes re-entered mitosis and were re-integrated into the epidermal pavement-cell layer, acquiring the typical characteristics of the surrounding epidermal cells.
  • [MeSH-minor] Cell Differentiation. Microscopy, Electron, Scanning. Models, Genetic. Mutation


68. Zhang C: MicroRNA-145 in vascular smooth muscle cell biology: a new therapeutic target for vascular disease. Cell Cycle; 2009 Nov 1;8(21):3469-73
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  • [Title] MicroRNA-145 in vascular smooth muscle cell biology: a new therapeutic target for vascular disease.
  • However, the roles of miR-145 in VSMC biology and vascular disease are unknown.
  • In our recent Circulation Research article, we found that the expression of miR-145 is significantly downregulated in dedifferentiated VSMCs and in balloon-injured arteries.
  • This review article summarizes the current research progress regarding the roles of miR-145 in VSMC biology and discusses the potential therapeutic opportunities surrounding this miRNA in vascular disease.

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  • (PMID = 19829088.001).
  • [ISSN] 1551-4005
  • [Journal-full-title] Cell cycle (Georgetown, Tex.)
  • [ISO-abbreviation] Cell Cycle
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / R01 HL080133-05; United States / NHLBI NIH HHS / HL / R01 HL080133; United States / NHLBI NIH HHS / HL / R01 HL095707; United States / NHLBI NIH HHS / HL / HL080133-05; United States / NHLBI NIH HHS / HL / HL080133
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / MIRN145 microRNA, human; 0 / MicroRNAs
  • [Number-of-references] 35
  • [Other-IDs] NLM/ NIHMS203148; NLM/ PMC3593963
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69. Vascotto SG, Beug S, Liversage RA, Tsilfidis C: Nvbeta-actin and NvGAPDH as normalization factors for gene expression analysis in limb regenerates and cultured blastema cells of the adult newt, Notophthalmus viridescens. Int J Dev Biol; 2005;49(7):833-42
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  • The red-spotted newt has the ability to fully regenerate complex structures by creating a pool of dedifferentiated cells that arise in response to tissue injury.
  • Nvbeta-actin demonstrates a heterogeneous expression during limb regeneration and may be associated with differentiation state.

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  • (PMID = 16172979.001).
  • [ISSN] 0214-6282
  • [Journal-full-title] The International journal of developmental biology
  • [ISO-abbreviation] Int. J. Dev. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Actins; EC 1.2.1.- / Glyceraldehyde-3-Phosphate Dehydrogenases
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70. El Ayoubi A, Poizat F, Garrel R, Costes V, Guerrier B, Essakalli L, Kzadri M, Crampette L: [Sinonasal adenocarcinomas reviewed. Prognostic value of WHO 2005 histological classification]. Ann Otolaryngol Chir Cervicofac; 2009 Sep;126(4):175-81
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  • [Transliterated title] Les adénocarcinomes nasosinusiens revisités. Intérêt pronostique de la classification histologique OMS 2005.
  • In the 50 remaining cases, there were 36 ITAC cases, four low-grade ADC cases and 10 high-grade dedifferentiated carcinomas.
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / analysis. Disease Progression. Female. Homeodomain Proteins / analysis. Humans. Immunohistochemistry. Kaplan-Meier Estimate. Keratin-20 / analysis. Keratin-7 / analysis. Male. Microfilament Proteins / analysis. Middle Aged. Prognosis. Receptor, Epidermal Growth Factor / analysis. Retrospective Studies. Trans-Activators / analysis. World Health Organization

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  • (PMID = 19591973.001).
  • [ISSN] 0003-438X
  • [Journal-full-title] Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Société d'oto-laryngologie des hôpitaux de Paris
  • [ISO-abbreviation] Ann Otolaryngol Chir Cervicofac
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Homeodomain Proteins; 0 / Keratin-20; 0 / Keratin-7; 0 / Microfilament Proteins; 0 / Trans-Activators; 0 / villin; 156560-97-3 / Cdx-2-3 protein; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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71. Wong AP, Nili N, Strauss BH: In vitro differences between venous and arterial-derived smooth muscle cells: potential modulatory role of decorin. Cardiovasc Res; 2005 Feb 15;65(3):702-10
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  • Venous SMC demonstrated increased expression of SMemb and decreased expression of SM1--markers of a dedifferentiated and differentiated phenotype, respectively.
  • CONCLUSION: Venous SMC are more dedifferentiated and demonstrate increased proliferative and synthetic capacity than arterial SMC.

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  • (PMID = 15664397.001).
  • [ISSN] 0008-6363
  • [Journal-full-title] Cardiovascular research
  • [ISO-abbreviation] Cardiovasc. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Decorin; 0 / Extracellular Matrix Proteins; 0 / Proteoglycans; 0 / Tissue Inhibitor of Metalloproteinases; 9007-34-5 / Collagen; EC 3.4.24.- / Gelatinases
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72. Nicol K, Savell V, Moore J, Teot L, Spunt SL, Qualman S, Children's Oncology Group, Soft Tissue Sarcoma Committee: Distinguishing undifferentiated embryonal sarcoma of the liver from biliary tract rhabdomyosarcoma: a Children's Oncology Group study. Pediatr Dev Pathol; 2007 Mar-Apr;10(2):89-97
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  • Histologically, hyaline globules and diffuse anaplasia were consistently present.
  • The cases of RMS had a male:female ratio of 1.8:1 with a median age of 3.4 years and routinely lacked diffuse anaplasia and hyaline globules.
  • [MeSH-minor] Child. Child, Preschool. Diagnosis, Differential. Disease-Free Survival. Female. Follow-Up Studies. Humans. Immunohistochemistry. Male. MyoD Protein / metabolism. Myogenin / metabolism. Neoplasm Proteins / metabolism. Retrospective Studies. Survival Analysis. Time Factors. Treatment Outcome


73. Bick RJ, Poindexter BJ, Schiess MC: Localization of calcitonin gene-related peptide in cardiomyocytes: comparison of neonatal and dedifferentiating cells to adult myocytes. Peptides; 2005 Feb;26(2):331-6
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  • [Title] Localization of calcitonin gene-related peptide in cardiomyocytes: comparison of neonatal and dedifferentiating cells to adult myocytes.
  • The purpose of this study was to localize sites of calcitonin gene-related peptide binding in neonatal, freshly isolated and dedifferentiated adult cardiac myocytes in order to help us elucidate the mechanisms of action of this neuropeptides.
  • Calcitonin gene-related protein was sparse and randomly distributed in rod-like adult cardiomyocytes, found in abundance in areas of the cell where striations were apparent and not where adhesion proteins predominated in dedifferentiating adult myocytes, and in a large perinuclear concentration, with some spreading into the cytoplasm in neonatal cells.
  • [MeSH-major] Aging / physiology. Calcitonin Gene-Related Peptide / metabolism. Cell Differentiation. Myocytes, Cardiac / metabolism

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  • (PMID = 15629546.001).
  • [ISSN] 0196-9781
  • [Journal-full-title] Peptides
  • [ISO-abbreviation] Peptides
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Calcium Channels, L-Type; 0 / Fluorescent Dyes; 83652-28-2 / Calcitonin Gene-Related Peptide; SY7Q814VUP / Calcium
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74. Uzuka T, Kakita A, Inenaga C, Takahashi H, Tanaka R, Takahashi H: Frontal anaplastic oligodendroglioma showing multi-organ metastases after a long clinical course. Case report. Neurol Med Chir (Tokyo); 2007 Apr;47(4):174-7
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  • [Title] Frontal anaplastic oligodendroglioma showing multi-organ metastases after a long clinical course. Case report.
  • A 17-year-old woman presented with an anaplastic oligodendroglioma manifesting as generalized seizure.
  • Total resection was repeated four times, and malignant change was evident within the tissues.
  • The final diagnosis was anaplastic oligodendroglioma.
  • This rare case of cerebral anaplastic oligodendroglioma developed in adolescence, and rapid hematogenous spread of the glioma cells into the systemic organs occurred after a relatively long clinical course.


75. Nakayama R, Nemoto T, Takahashi H, Ohta T, Kawai A, Seki K, Yoshida T, Toyama Y, Ichikawa H, Hasegawa T: Gene expression analysis of soft tissue sarcomas: characterization and reclassification of malignant fibrous histiocytoma. Mod Pathol; 2007 Jul;20(7):749-59
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  • Spindle cell and pleomorphic sarcomas, such as dedifferentiated liposarcoma, myxofibrosarcoma, leiomyosarcoma, malignant peripheral nerve sheath tumor (MPNST), fibrosarcoma and MFH, showed similar gene expression patterns compared to other tumors.
  • We calculated distances between MFH samples and other five sarcoma types (dedifferentiated liposarcoma, myxofibrosarcoma, leiomyosarcoma, MPNST and fibrosarcoma) based on differentially expressed genes and evaluated similarities.

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  • (PMID = 17464315.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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76. Lee K, Yun ST, Kim YG, Yoon Y, Jo EC: Adeno-associated virus-mediated expression of apolipoprotein (a) kringles suppresses hepatocellular carcinoma growth in mice. Hepatology; 2006 May;43(5):1063-73
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  • HCC is a hypervascular tumor that develops from dedifferentiation of small avascular HCC and is therefore a good target for anti-angiogenic gene therapy.

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  • (PMID = 16628632.001).
  • [ISSN] 0270-9139
  • [Journal-full-title] Hepatology (Baltimore, Md.)
  • [ISO-abbreviation] Hepatology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Apolipoproteins A
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77. Lu QY, Jin YS, Pantuck A, Zhang ZF, Heber D, Belldegrun A, Brooks M, Figlin R, Rao J: Green tea extract modulates actin remodeling via Rho activity in an in vitro multistep carcinogenic model. Clin Cancer Res; 2005 Feb 15;11(4):1675-83
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  • Alteration of actin polymerization and loss of actin filaments is a marker of cellular dedifferentiation and early malignant transformation.
  • GTE induces actin polymerization in MC-T11 cells in a dose-responsive manner, but this effect is less obvious in the untransformed, more differentiated HUC-PC cells, which natively have higher actin polymerization status.

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  • (PMID = 15746073.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Grant] United States / NCCIH NIH HHS / AT / AT00151-01; United States / NCI NIH HHS / CA / U01CA96116
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Aminobiphenyl Compounds; 0 / Carcinogens; 0 / Cytochalasins; 0 / Plant Extracts; 0 / Polymers; 0 / Tea; 16054949HJ / 4-biphenylamine; 36011-19-5 / cytochalasin E; EC 3.6.5.2 / rho GTP-Binding Proteins
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78. Hyun O J, Yoo IeR, Jung CK, Hoon Kim S, Chung SK: F-18 FDG PET/CT findings of dedifferentiated acinic cell carcinoma. Clin Nucl Med; 2010 Jun;35(6):473-4
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  • [Title] F-18 FDG PET/CT findings of dedifferentiated acinic cell carcinoma.
  • [MeSH-major] Cell Dedifferentiation. Fluorodeoxyglucose F18. Parotid Neoplasms / diagnosis. Parotid Neoplasms / pathology. Positron-Emission Tomography. Tomography, X-Ray Computed

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  • (PMID = 20479609.001).
  • [ISSN] 1536-0229
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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79. Motta FJ, Valera ET, Lucio-Eterovic AK, Queiroz RG, Neder L, Scrideli CA, Machado HR, Carlotti-Junior CG, Marie SK, Tone LG: Differential expression of E-cadherin gene in human neuroepithelial tumors. Genet Mol Res; 2008;7(2):295-304
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  • These results suggest that a decrease in E-cadherin gene expression level in high-grade neuroepithelial tumors may be a hallmark of malignancy in dedifferentiated tumors and that it may be possibly correlated with their progression and dissemination.

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  • (PMID = 18551395.001).
  • [ISSN] 1676-5680
  • [Journal-full-title] Genetics and molecular research : GMR
  • [ISO-abbreviation] Genet. Mol. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / Cadherins; 0 / RNA, Messenger
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80. Kucia M, Reca R, Jala VR, Dawn B, Ratajczak J, Ratajczak MZ: Bone marrow as a home of heterogenous populations of nonhematopoietic stem cells. Leukemia; 2005 Jul;19(7):1118-27
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  • Thus, since BM contains versatile nonhematopoietic stem cells, previous studies on plasticity trans-dedifferentiation of BM-derived hematopoietic stem cells (HSC) that did not include proper controls to exclude this possibility could lead to wrong interpretations.

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  • (PMID = 15902288.001).
  • [ISSN] 0887-6924
  • [Journal-full-title] Leukemia
  • [ISO-abbreviation] Leukemia
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01 CA106281-01
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Receptors, Chemokine
  • [Number-of-references] 110
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81. Coelho SM, Carvalho DP, Vaisman M: New perspectives on the treatment of differentiated thyroid cancer. Arq Bras Endocrinol Metabol; 2007 Jun;51(4):612-24
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  • [Title] New perspectives on the treatment of differentiated thyroid cancer.
  • Even though differentiated thyroid carcinoma is a slow growing and usually curable disease, recurrence occurs in 20-40% and cellular dedifferentiation in up to 5% of cases.
  • Therefore, dedifferentiated thyroid cancer represents a therapeutic dilemma and a critical area of research.

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  • (PMID = 17684624.001).
  • [ISSN] 0004-2730
  • [Journal-full-title] Arquivos brasileiros de endocrinologia e metabologia
  • [ISO-abbreviation] Arq Bras Endocrinol Metabol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Iodine Radioisotopes; 0 / Protein Kinase Inhibitors; EC 2.7.10.1 / Protein-Tyrosine Kinases
  • [Number-of-references] 105
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82. Terhune DB: The incidence and determinants of visual phenomenology during out-of-body experiences. Cortex; 2009 Feb;45(2):236-42
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  • This account proposes that visual content appears during these experiences through a process of cognitive dedifferentiation in which visual hallucinations are derived from available non-visual sensory cues and that such dedifferentiation is made possible through an underlying characteristic hyperconnectivity of cortical structures regulating vestibular and visual representations of the body and those responsible for the rotation of environmental objects.

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  • (PMID = 18621365.001).
  • [ISSN] 0010-9452
  • [Journal-full-title] Cortex; a journal devoted to the study of the nervous system and behavior
  • [ISO-abbreviation] Cortex
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Italy
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83. Barth AS, Merk S, Arnoldi E, Zwermann L, Kloos P, Gebauer M, Steinmeyer K, Bleich M, Kääb S, Hinterseer M, Kartmann H, Kreuzer E, Dugas M, Steinbeck G, Nabauer M: Reprogramming of the human atrial transcriptome in permanent atrial fibrillation: expression of a ventricular-like genomic signature. Circ Res; 2005 May 13;96(9):1022-9
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  • Atrial fibrillation is associated with increased expression of ventricular myosin isoforms in atrial myocardium, regarded as part of a dedifferentiation process.
  • Therefore, dedifferentiation with adoption of a ventricular-like signature is a general feature of the fibrillating atrium.

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  • [CommentIn] Circ Res. 2005 May 13;96(9):923-4 [15890977.001]
  • (PMID = 15817885.001).
  • [ISSN] 1524-4571
  • [Journal-full-title] Circulation research
  • [ISO-abbreviation] Circ. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Messenger; SY7Q814VUP / Calcium
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84. Wehler TC, Graf C, Biesterfeld S, Brenner W, Schadt J, Gockel I, Berger MR, Thüroff JW, Galle PR, Moehler M, Schimanski CC: Strong expression of chemokine receptor CXCR4 by renal cell carcinoma correlates with advanced disease. J Oncol; 2008;2008:626340
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  • [Title] Strong expression of chemokine receptor CXCR4 by renal cell carcinoma correlates with advanced disease.
  • Strong CXCR4 expression of renal cell carcinoma was significantly associated with advanced T-status (P = .039), tumor dedifferentiation (P = .0005), and low hemoglobin (P = .039).
  • In summary, strong CXCR4 expression was significantly associated with advanced dedifferentiated renal cell carcinoma.

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  • (PMID = 19266088.001).
  • [ISSN] 1687-8450
  • [Journal-full-title] Journal of oncology
  • [ISO-abbreviation] J Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC2648639
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85. Shao C, Song W, Li L, Warren A, Al-Rasheid KA, Al-Quraishy SA, Al-Farraj SA, Lin X: Systematic position of Discocephalus-like ciliates (Ciliophora: Spirotrichea) inferred from SSU rDNA and ontogenetic information. Int J Syst Evol Microbiol; 2008 Dec;58(Pt 12):2962-72
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  • In the present study, the cortical development of Prodiscocephalus borrori was observed during binary division and this can be summarized as follows: (i) in the parental adoral zone of membranelles, only the posterior end is renewed by dedifferentiation of the old structures;.
  • (ii) the oral primordium in the opisthe occurs de novo on the cell surface as seen in other typical stichotrichs;.

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  • (PMID = 19060090.001).
  • [ISSN] 1466-5026
  • [Journal-full-title] International journal of systematic and evolutionary microbiology
  • [ISO-abbreviation] Int. J. Syst. Evol. Microbiol.
  • [Language] eng
  • [Databank-accession-numbers] GENBANK/ DQ646880
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Ribosomal
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86. Flieger A, Golka K, Schulze H, Follmann W: Primary cultures of human urothelial cells for genotoxicity testing. J Toxicol Environ Health A; 2008;71(13-14):930-5
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  • The epithelial origin and differentiation status was evaluated by an immunohistochemical staining for cytokeratins 7, 8, 18, 19, and 20 for isolated and cultured cells.
  • During prolonged cell culture the cytokeratin patterns of the human urothelial cells (HUC) changed into a beginning dedifferentiation: Cytokeratin (CK) 18 was only detectable in cell cultures cultured for more than 29 d, whereas CK 19 was not detectable at d 29.

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  • (PMID = 18569598.001).
  • [ISSN] 1528-7394
  • [Journal-full-title] Journal of toxicology and environmental health. Part A
  • [ISO-abbreviation] J. Toxicol. Environ. Health Part A
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] EC 1.1.1.27 / L-Lactate Dehydrogenase
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87. Sugitani I: [Surgical treatment of locally advanced differentiated thyroid carcinoma]. Nihon Geka Gakkai Zasshi; 2005 Aug;106(8):463-7
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  • [Title] [Surgical treatment of locally advanced differentiated thyroid carcinoma].
  • Patients with differentiated thyroid carcinoma (DTC), especially with papillary carcinoma, occasionally have direct tumor extension with invasion of surrounding tissues The presence of extrathyroidal invasion is one of the most important risk factors for mortality from DTC.
  • They claim that these high-risk patients frequently have distant metastases and tumor dedifferentiation, and that survival advantage from extended surgery at the expense of significant morbidity is unclear.

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  • (PMID = 16119108.001).
  • [ISSN] 0301-4894
  • [Journal-full-title] Nihon Geka Gakkai zasshi
  • [ISO-abbreviation] Nihon Geka Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 17
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88. Hanna SA, Tirabosco R, Amin A, Pollock RC, Skinner JA, Cannon SR, Saifuddin A, Briggs TW: Dedifferentiated chordoma: a report of four cases arising 'de novo'. J Bone Joint Surg Br; 2008 May;90(5):652-6
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  • [Title] Dedifferentiated chordoma: a report of four cases arising 'de novo'.
  • Dedifferentiated chordoma is a rare and aggressive variant of the conventional tumour in which an area undergoes transformation to a high-grade lesion, typically fibrous histiocytoma, fibrosarcoma, and rarely, osteosarcoma or rhabdomyosarcoma.
  • The dedifferentiated component dictates overall survival, with smaller areas of dedifferentiation carrying a more favourable prognosis.
  • We describe four such cases, which were diagnosed de novo following primary excision, and discuss the associated clinical and radiological features.

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  • (PMID = 18450635.001).
  • [ISSN] 0301-620X
  • [Journal-full-title] The Journal of bone and joint surgery. British volume
  • [ISO-abbreviation] J Bone Joint Surg Br
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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89. Le Pape E, Passeron T, Giubellino A, Valencia JC, Wolber R, Hearing VJ: Microarray analysis sheds light on the dedifferentiating role of agouti signal protein in murine melanocytes via the Mc1r. Proc Natl Acad Sci U S A; 2009 Feb 10;106(6):1802-7
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  • [Title] Microarray analysis sheds light on the dedifferentiating role of agouti signal protein in murine melanocytes via the Mc1r.
  • These results demonstrate the role of ASP in the dedifferentiation of melanocytes, identify pigment-related genes targeted by ASP and by alphaMSH, and provide insights into the pleiotropic molecular effects of MC1R signaling that may function during development and may affect skin cancer risk.

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  • (PMID = 19174519.001).
  • [ISSN] 1091-6490
  • [Journal-full-title] Proceedings of the National Academy of Sciences of the United States of America
  • [ISO-abbreviation] Proc. Natl. Acad. Sci. U.S.A.
  • [Language] ENG
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Agouti Signaling Protein; 0 / Ligands; 0 / Receptor, Melanocortin, Type 1; 581-05-5 / alpha-MSH
  • [Other-IDs] NLM/ PMC2644118
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90. Slack JM: Amphibian muscle regeneration--dedifferentiation or satellite cells? Trends Cell Biol; 2006 Jun;16(6):273-5
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  • [Title] Amphibian muscle regeneration--dedifferentiation or satellite cells?
  • Mammalian muscle repair occurs through the mobilization of muscle satellite cells, whereas the new muscle in amphibian appendage regeneration was believed to arise by dedifferentiation of myofibres to form myoblasts.
  • But recent work shows that muscle satellite cells are also involved in amphibian regeneration and the controversy about the reality of muscle dedifferentiation is heating up again.
  • [MeSH-minor] Animals. Cell Differentiation. Myoblasts / physiology. Wound Healing

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  • (PMID = 16697200.001).
  • [ISSN] 0962-8924
  • [Journal-full-title] Trends in cell biology
  • [ISO-abbreviation] Trends Cell Biol.
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / G0300415
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 31
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91. Masereeuw R: Contribution of bone marrow-derived cells in renal repair after acute kidney injury. Minerva Urol Nefrol; 2009 Dec;61(4):373-84
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  • Tubular cells can restore renal function by proliferation and dedifferentiation into a mesenchymal cell-type, but also stem cells residing in bone marrow (BM) have been suggested to contribute.
  • Trans-differentiation of BM cells to functional tubular epithelium has been demonstrated previously, however, beneficial effects of BM transplantations may have been accelerated by irradiation of mice prior to transplantation and kidney injury.

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  • (PMID = 19816390.001).
  • [ISSN] 0393-2249
  • [Journal-full-title] Minerva urologica e nefrologica = The Italian journal of urology and nephrology
  • [ISO-abbreviation] Minerva Urol Nefrol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 63
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92. Lorenzo-López L, Amenedo E, Pazo-Alvarez P, Cadaveira F: Visual target processing in high- and low-performing older subjects indexed by P3 component. Neurophysiol Clin; 2007 Apr-May;37(2):53-61
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  • The implications of this finding for the actual compensation versus dedifferentiation debate in normal aging are discussed.

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  • (PMID = 17540288.001).
  • [ISSN] 0987-7053
  • [Journal-full-title] Neurophysiologie clinique = Clinical neurophysiology
  • [ISO-abbreviation] Neurophysiol Clin
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] France
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93. Miyoshi A, Kitajima Y, Kido S, Shimonishi T, Matsuyama S, Kitahara K, Miyazaki K: Snail accelerates cancer invasion by upregulating MMP expression and is associated with poor prognosis of hepatocellular carcinoma. Br J Cancer; 2005 Jan 31;92(2):252-8
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  • In the nodule-in-nodule tumours, Snail expression significantly increased with tumour dedifferentiation (P=0.047).

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  • (PMID = 15668718.001).
  • [ISSN] 0007-0920
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
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94. Silva J, Nichols J, Theunissen TW, Guo G, van Oosten AL, Barrandon O, Wray J, Yamanaka S, Chambers I, Smith A: Nanog is the gateway to the pluripotent ground state. Cell; 2009 Aug 21;138(4):722-37
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  • In transcription factor-induced molecular reprogramming, Nanog is initially dispensable but becomes essential for dedifferentiated intermediates to transit to ground state pluripotency.
  • [MeSH-minor] Adult Stem Cells / cytology. Animals. Blastocyst / cytology. Cell Dedifferentiation. Embryonic Stem Cells / cytology. Female. Germ Layers / cytology. Mice. Nanog Homeobox Protein. X Chromosome / metabolism

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  • (PMID = 19703398.001).
  • [ISSN] 1097-4172
  • [Journal-full-title] Cell
  • [ISO-abbreviation] Cell
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / ; United Kingdom / Biotechnology and Biological Sciences Research Council / / ; United Kingdom / Medical Research Council / / G0700665; United Kingdom / Medical Research Council / / G9806702; United Kingdom / Wellcome Trust / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Homeodomain Proteins; 0 / Nanog Homeobox Protein; 0 / Nanog protein, mouse
  • [Other-IDs] NLM/ PMC3437554
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95. Macary G, Rossert J, Bruneval P, Mandet C, Bélair MF, Houillier P, Duong Van Huyen JP: Transgenic mice expressing nitroreductase gene under the control of the podocin promoter: a new murine model of inductible glomerular injury. Virchows Arch; 2010 Mar;456(3):325-37
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  • The phenotype of podocytes was changed exhibiting dedifferentiation characterized by the loss of podocyte specific proteins/transcription factor and the expression of injury markers.
  • [MeSH-minor] Animals. Aziridines / metabolism. Disease Models, Animal. Female. Mice. Mice, Transgenic. Podocytes / pathology. Promoter Regions, Genetic / physiology

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  • (PMID = 19806361.001).
  • [ISSN] 1432-2307
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Aziridines; 0 / Intracellular Signaling Peptides and Proteins; 0 / Membrane Proteins; 0 / NPHS2 protein; 7865D5D01M / tretazicar; EC 1.7.- / Nitroreductases
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96. Baeyens L, Bouwens L: Can beta-cells be derived from exocrine pancreas? Diabetes Obes Metab; 2008 Nov;10 Suppl 4:170-8
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  • After an initial step of dedifferentiation, they can be redirected to the beta-cell phenotype by adding agonists of the JAK2/STAT3 signalling pathway to the medium (epidermal growth factor and leukaemia inhibitory factor).
  • [MeSH-minor] Animals. Biomedical Research. Cell Differentiation / physiology. Female. Humans. Insulin / metabolism. Islets of Langerhans / cytology. Islets of Langerhans / metabolism. Islets of Langerhans / physiology. Male. Mice. Signal Transduction / physiology


97. Caslini C, Capo-chichi CD, Roland IH, Nicolas E, Yeung AT, Xu XX: Histone modifications silence the GATA transcription factor genes in ovarian cancer. Oncogene; 2006 Aug 31;25(39):5446-61
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  • Altered expression of GATA factors was found and proposed as the underlying mechanism for dedifferentiation in ovarian carcinogenesis.

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  • (PMID = 16607277.001).
  • [ISSN] 0950-9232
  • [Journal-full-title] Oncogene
  • [ISO-abbreviation] Oncogene
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA006927; United States / NCI NIH HHS / CA / P50 CA83638; United States / NCI NIH HHS / CA / R01 CA75389; United States / NCI NIH HHS / CA / R01 CA79716
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / DAB2 protein, human; 0 / GATA Transcription Factors; 0 / GATA4 Transcription Factor; 0 / GATA6 Transcription Factor; 0 / Heterochromatin; 0 / Histones; 0 / Tumor Suppressor Proteins; K3Z4F929H6 / Lysine
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98. Doi H, Iso T, Yamazaki M, Akiyama H, Kanai H, Sato H, Kawai-Kowase K, Tanaka T, Maeno T, Okamoto E, Arai M, Kedes L, Kurabayashi M: HERP1 inhibits myocardin-induced vascular smooth muscle cell differentiation by interfering with SRF binding to CArG box. Arterioscler Thromb Vasc Biol; 2005 Nov;25(11):2328-34
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  • [Title] HERP1 inhibits myocardin-induced vascular smooth muscle cell differentiation by interfering with SRF binding to CArG box.
  • OBJECTIVE: Myocardin is a coactivator of serum response factor (SRF) required for vascular smooth muscle cell (VSMC) differentiation.
  • CONCLUSIONS: HERP1 expression was associated with the SMC proliferation and dedifferentiation in vitro and in vivo.
  • [MeSH-major] Angioplasty, Balloon / adverse effects. Basic Helix-Loop-Helix Transcription Factors / metabolism. Coronary Artery Disease / pathology. Muscle, Smooth, Vascular / pathology. Nuclear Proteins / metabolism. Repressor Proteins / metabolism. Serum Response Factor / metabolism. Trans-Activators / metabolism
  • [MeSH-minor] Adult. Animals. Aorta / injuries. Aorta / pathology. Aortic Diseases / etiology. Aortic Diseases / metabolism. Aortic Diseases / pathology. Atherectomy, Coronary. Cell Differentiation / physiology. Cell Division / physiology. Cells, Cultured. Coronary Vessels / injuries. Coronary Vessels / metabolism. Coronary Vessels / pathology. Gene Expression. Genetic Markers. Humans. Microfilament Proteins / genetics. Muscle Proteins / genetics. Myosin Heavy Chains / genetics. Promoter Regions, Genetic / physiology. RNA, Messenger / analysis. Rats. Rats, Wistar. Smooth Muscle Myosins / metabolism. Tunica Intima / metabolism. Tunica Intima / pathology

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  • Gene Ontology. gene/protein/disease-specific - Gene Ontology annotations from this paper .
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  • (PMID = 16151017.001).
  • [ISSN] 1524-4636
  • [Journal-full-title] Arteriosclerosis, thrombosis, and vascular biology
  • [ISO-abbreviation] Arterioscler. Thromb. Vasc. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Basic Helix-Loop-Helix Transcription Factors; 0 / Genetic Markers; 0 / HEY2 protein, human; 0 / Microfilament Proteins; 0 / Muscle Proteins; 0 / Nuclear Proteins; 0 / RNA, Messenger; 0 / Repressor Proteins; 0 / SRF protein, human; 0 / Serum Response Factor; 0 / Trans-Activators; 0 / myocardin; 0 / transgelin; EC 3.6.1.- / Smooth Muscle Myosins; EC 3.6.4.1 / Myosin Heavy Chains
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99. Stiles CD, Rowitch DH: Glioma stem cells: a midterm exam. Neuron; 2008 Jun 26;58(6):832-46
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  • Do glioma stem cells arise from developmentally stalled neural progenitors or from dedifferentiated astrocytes?

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  • (PMID = 18579075.001).
  • [ISSN] 1097-4199
  • [Journal-full-title] Neuron
  • [ISO-abbreviation] Neuron
  • [Language] ENG
  • [Grant] United States / NINDS NIH HHS / NS / P01 NS047572; United States / NINDS NIH HHS / NS / P01NS047572; United States / NINDS NIH HHS / NS / R01NS057727
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 34
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100. Linke K, Schanz J, Hansmann J, Walles T, Brunner H, Mertsching H: Engineered liver-like tissue on a capillarized matrix for applied research. Tissue Eng; 2007 Nov;13(11):2699-707
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  • Tissue morphology and differentiation was monitored using histology and immunohistochemistry.
  • It was viable for 3 weeks, and HCs maintained their morphology and differentiation.
  • In contrast, HCs cultured in monolayer showed morphological dedifferentiation and an unfavorable metabolic state.
  • [MeSH-minor] Animals. Cell Differentiation. Cells, Cultured. Coculture Techniques. Collagen Type I / metabolism. Gels. Immunohistochemistry. Jejunum / blood supply. Lactates. Models, Biological. Sus scrofa. Time Factors. Urea / metabolism

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  • (PMID = 17867928.001).
  • [ISSN] 1076-3279
  • [Journal-full-title] Tissue engineering
  • [ISO-abbreviation] Tissue Eng.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Collagen Type I; 0 / Gels; 0 / Lactates; 8W8T17847W / Urea
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