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1. Larsson K, Kåreholt I, Thorslund M: Care utilisation in the last years of life in relation to age and time to death: results from a Swedish urban population of the oldest old. Eur J Ageing; 2008 Dec;5(4):349-357

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  • The proportion residing in institutional care facilities with around-the-clock care increased steadily with a sharper gradient 6 months before death.

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  • (PMID = 28798585.001).
  • [ISSN] 1613-9372
  • [Journal-full-title] European journal of ageing
  • [ISO-abbreviation] Eur J Ageing
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Keywords] NOTNLM ; End-of-life care / Hospitalisation / Institutionalisation / Swedish elder care
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2. Ito Y, Higashiyama T, Hirokawa M, Fukushima M, Inoue H, Yabuta T, Tomoda C, Uruno T, Kihara M, Takamura Y, Miya A, Kobayashi K, Matsuzuka F, Miyauchi A: Investigation of the validity of UICC stage grouping of anaplastic carcinoma of the thyroid. Asian J Surg; 2009 Jan;32(1):47-50
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  • [Title] Investigation of the validity of UICC stage grouping of anaplastic carcinoma of the thyroid.
  • OBJECTIVE: Anaplastic thyroid carcinoma arises from differentiated carcinoma and has a very aggressive character.
  • In this study, we investigated the prognosis of patients with anaplastic carcinoma based on UICC stage.
  • PATIENTS AND METHODS: We investigated the prognosis of 75 patients who were diagnosed as having anaplastic carcinoma at Kuma Hospital between 1983 and 2006.
  • All patients with Stage IVC died of carcinoma within 1 year regardless of whether locally complete resection was performed.

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  • (PMID = 19321402.001).
  • [ISSN] 1015-9584
  • [Journal-full-title] Asian journal of surgery
  • [ISO-abbreviation] Asian J Surg
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] China
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3. Naranjo-Gómez JM, Folqué-Gómez E, Moreno-Mata N, Moldes-Rodríguez M, Martínez-Martínez P, González-Aragoneses F, Orusco-Palomino E: [Insular carcinoma of the thyroid. An uncommon but aggressive neoplasm]. Cir Esp; 2005 Apr;77(4):236-9
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  • [Title] [Insular carcinoma of the thyroid. An uncommon but aggressive neoplasm].
  • [Transliterated title] Carcinoma insular de tiroides. Una neoplasia poco frecuente pero agresiva.
  • Insular carcinoma of the thyroid is an infrequent entity, named in 1984 by Carcangiu when he described its characteristic histology.
  • Clinically and morphologically it is considered to be in an intermediate position between well-differentiated carcinoma of the thyroid (papillary or follicular) and undifferentiated or anaplastic carcinoma of the thyroid.
  • The prognosis of this tumor is worse than that of classic carcinoma of the thyroid, and most authors advise aggressive therapy, which in some cases can achieved prolonged survival.
  • [MeSH-major] Carcinoma / pathology. Thyroid Neoplasms / pathology

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  • (PMID = 16420925.001).
  • [ISSN] 0009-739X
  • [Journal-full-title] Cirugía española
  • [ISO-abbreviation] Cir Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 12
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4. Nikiforov YE: Editorial: anaplastic carcinoma of the thyroid--will aurora B light a path for treatment? J Clin Endocrinol Metab; 2005 Feb;90(2):1243-5
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  • [Title] Editorial: anaplastic carcinoma of the thyroid--will aurora B light a path for treatment?
  • [MeSH-major] Carcinoma / genetics. Protein-Serine-Threonine Kinases / genetics. Thyroid Neoplasms / genetics

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  • (PMID = 15699543.001).
  • [ISSN] 0021-972X
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Editorial
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.11.1 / AURKB protein, human; EC 2.7.11.1 / Aurora Kinase B; EC 2.7.11.1 / Aurora Kinases; EC 2.7.11.1 / Protein-Serine-Threonine Kinases
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5. Groth JJ, Ayers SF, Miller MG, Arbogast WD: Self-reported health and fitness habits of certified athletic trainers. J Athl Train; 2008 Oct-Dec;43(6):617-23
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  • [Title] Self-reported health and fitness habits of certified athletic trainers.
  • CONTEXT: As health care providers, certified athletic trainers (ATs) should be role models for healthy behaviors.

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  • (PMID = 19030140.001).
  • [ISSN] 1938-162X
  • [Journal-full-title] Journal of athletic training
  • [ISO-abbreviation] J Athl Train
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2582554
  • [Keywords] NOTNLM ; exercise / nutrition / role models
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6. Figueroa-Casas JB, Montoya R, Arzabala A, Connery SM: Comparison between automatic tube compensation and continuous positive airway pressure during spontaneous breathing trials. Respir Care; 2010 May;55(5):549-54
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  • [Title] Comparison between automatic tube compensation and continuous positive airway pressure during spontaneous breathing trials.
  • Automatic tube compensation (ATC) is a new and potentially advantageous ventilation mode to use during SBT.
  • We compared ATC to continuous positive airway pressure (CPAP) during SBTs, to determine their efficacy in identifying patients ready to be liberated from mechanical ventilation.
  • METHODS: We randomized 118 adults in a general intensive care unit on mechanical ventilation for > or = 24 h who were about to undergo an SBT as part of an established respiratory-therapist-driven weaning protocol to undergo 30 min SBT with ATC or CPAP with no pressure support.
  • RESULTS: We found a trend toward less failure of first SBT with ATC, compared to CPAP (3% vs 13% respectively, P = .09), but no difference in duration of weaning, rate of unsuccessful extubation, or duration of mechanical ventilation.
  • CONCLUSIONS: When applied as part of a respiratory-therapist-driven weaning protocol in a general intensive-care population, SBTs with ATC were safe but did not hasten liberation from mechanical ventilation, when compared to CPAP.

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  • [CommentIn] Respir Care. 2010 May;55(5):640-2 [20420738.001]
  • (PMID = 20420724.001).
  • [ISSN] 0020-1324
  • [Journal-full-title] Respiratory care
  • [ISO-abbreviation] Respir Care
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
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7. Kania ML, Meyer BB, Ebersole KT: Personal and environmental characteristics predicting burnout among certified athletic trainers at National Collegiate Athletic Association institutions. J Athl Train; 2009 Jan-Feb;44(1):58-66
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Personal and environmental characteristics predicting burnout among certified athletic trainers at National Collegiate Athletic Association institutions.
  • OBJECTIVE: To examine the relationship between selected personal and environmental characteristics and burnout among certified athletic trainers (ATs).
  • PATIENTS OR OTHER PARTICIPANTS: A total of 206 ATs employed at National Collegiate Athletic Association (NCAA) institutions as clinical ATs volunteered.
  • The results also support the Cognitive-Affective Model of Athletic Burnout proposed by Smith.

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  • (PMID = 19180220.001).
  • [ISSN] 1938-162X
  • [Journal-full-title] Journal of athletic training
  • [ISO-abbreviation] J Athl Train
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2629041
  • [Keywords] NOTNLM ; professional development / work pressure / work stress
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8. Strobel K, Steinert HC, Bhure U, Koma AY, Gassmann N, Stöckli SJ: Tumour thrombus in the superior vena cava from anaplastic carcinoma of the thyroid: FDG-PET/CT imaging findings. Eur J Nucl Med Mol Imaging; 2007 May;34(5):813
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  • [Title] Tumour thrombus in the superior vena cava from anaplastic carcinoma of the thyroid: FDG-PET/CT imaging findings.
  • [MeSH-major] Carcinoma / radionuclide imaging. Fluorodeoxyglucose F18. Positron-Emission Tomography / methods. Thyroid Neoplasms / complications. Thyroid Neoplasms / radionuclide imaging. Tomography, X-Ray Computed / methods. Vena Cava, Superior / radionuclide imaging. Venous Thrombosis / radionuclide imaging

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  • (PMID = 17225114.001).
  • [ISSN] 1619-7070
  • [Journal-full-title] European journal of nuclear medicine and molecular imaging
  • [ISO-abbreviation] Eur. J. Nucl. Med. Mol. Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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9. Moscetti L, Padalino D, Capomolla E, Nelli F, Pollera CF: A partial response in anaplastic carcinoma of the thyroid with liposomal doxorubicin. J Exp Clin Cancer Res; 2005 Mar;24(1):151-4
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  • [Title] A partial response in anaplastic carcinoma of the thyroid with liposomal doxorubicin.
  • Anaplastic thyroid carcinoma is a rare disease with a poor prognosis.
  • Surgery represents the curative treatment for limiting the disease.
  • In the presence of locoregional disease, not suitable for surgery, and for metastastic disease, chemotherapy represents the treatment option.
  • Liposomal doxorubicin is a new class of anthracyclines, derived from a structural modification of doxorubicin, representing a new form of an old drug with pharmacological characteristics that facilitate a more easy elusion from immune system, a longer half-life, an increased tumor cell uptake and a reduced toxicity if compared with parental drug.
  • Herein we report the first case of an anaplastic thyroid carcinoma treated with the use of liposomal doxorubicin.
  • [MeSH-major] Doxorubicin / administration & dosage. Doxorubicin / therapeutic use. Liposomes. Thyroid Neoplasms / drug therapy

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  • (PMID = 15943045.001).
  • [ISSN] 0392-9078
  • [Journal-full-title] Journal of experimental & clinical cancer research : CR
  • [ISO-abbreviation] J. Exp. Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Liposomes; 80168379AG / Doxorubicin
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10. Cerilli LA, Frable WJ, Spafford MF: Anaplastic carcinoma of the thyroid with chondroblastoma features mimicking papillary carcinoma: a case report. Acta Cytol; 2007 Sep-Oct;51(5):825-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anaplastic carcinoma of the thyroid with chondroblastoma features mimicking papillary carcinoma: a case report.
  • BACKGROUND: An unusual case of anaplastic carcinoma of the thyroid arising from a metastatic focus of papillary carcinoma.
  • CASE: The tumor affected a 69-year-old woman with a history of total thyroidectomy for papillary thyroid carcinoma 4 years previously.
  • A small, embedded focus of residual follicular variant of papillary carcinoma was present.
  • The patient died of disease 3 months later.
  • CONCLUSION: This "chondroblastoma" variant of anaplastic thyroid carcinoma has not been reported to date.
  • [MeSH-major] Carcinoma / pathology. Carcinoma, Papillary / pathology. Chondroblastoma / pathology. Thyroid Neoplasms / pathology

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  • (PMID = 17910356.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 68238-35-7 / Keratins
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11. Besic N, Hocevar M, Zgajnar J, Pogacnik A, Grazio-Frkovic S, Auersperg M: Prognostic factors in anaplastic carcinoma of the thyroid-a multivariate survival analysis of 188 patients. Langenbecks Arch Surg; 2005 Jun;390(3):203-8
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  • [Title] Prognostic factors in anaplastic carcinoma of the thyroid-a multivariate survival analysis of 188 patients.
  • BACKGROUND: Multivariate studies concerning the prognosis of patients with anaplastic carcinoma of the thyroid gland are scarce.
  • The aim of our study was to determine the prognostic factors associated with survival of patients with anaplastic carcinoma in Slovenia, an iodine-deficient region.
  • METHODS: This retrospective study was carried out on a group of 188 patients (130 female, 58 male; median age 68 years) with anaplastic carcinoma of the thyroid who had been treated at a tertiary care centre from 1972 to 2003.
  • For each patient, data on gender, age, disease history, extent of disease, morphological characteristics, mode of therapy, and survival were collected.
  • CONCLUSION: Patients younger than 71 years, with a good performance status and slowly growing tumours confined to the thyroid, and without distant metastases, had the best prognosis.

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  • (PMID = 15599758.001).
  • [ISSN] 1435-2443
  • [Journal-full-title] Langenbeck's archives of surgery
  • [ISO-abbreviation] Langenbecks Arch Surg
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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12. Carda C, Ferrer J, Vilanova M, Peydró A, Llombart-Bosch A: Anaplastic carcinoma of the thyroid with rhabdomyosarcomatous differentiation: a report of two cases. Virchows Arch; 2005 Jan;446(1):46-51
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  • [Title] Anaplastic carcinoma of the thyroid with rhabdomyosarcomatous differentiation: a report of two cases.
  • Anaplastic carcinoma of the thyroid gland (ACT) is a highly malignant tumor that is almost invariably associated with a fatal outcome.
  • Both cases disclosed a very similar histological appearance, with a main population of small, pleomorphic, round-to-oval cells arranged in a storiform pattern, admixed with scattered pleomorphic giant cells, an image similar to that of the usual type of MFH.
  • At the ultrastructural level, the cells disclosed the same spindle and pleomorphic morphology, with large, bizarre nuclei and cytoplasm with abundant mitochondria, rough endoplasmic reticulum, secretory granules and lipid droplets.
  • [MeSH-major] Carcinoma / pathology. Rhabdomyosarcoma / pathology. Thyroid Neoplasms / pathology

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  • (PMID = 15517365.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / MyoD Protein; 0 / MyoD1 myogenic differentiation protein; 0 / Myoglobin
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13. Oktay MH, Smolkin MB, Williams M, Cajigas A: Metastatic anaplastic carcinoma of the thyroid mimicking squamous cell carcinoma: report of a case of a challenging cytologic diagnosis. Acta Cytol; 2006 Mar-Apr;50(2):201-4
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  • [Title] Metastatic anaplastic carcinoma of the thyroid mimicking squamous cell carcinoma: report of a case of a challenging cytologic diagnosis.
  • BACKGROUND: The probability of anaplastic transformation in a differentiated thyroid carcinoma (DTC) is <2%.
  • Admixture of DTC and undifferentiated carcinoma can occasionally be found in thyroidectomy specimens, or the undifferentiated tumor may develop in metastatic foci months or years after removal of the primary tumor.
  • CASE: Anaplastic transformation of a metastatic DTC was diagnosed at autopsy in a 71-year-old female.
  • At the time of her total thyroidectomy for follicular carcinoma, she already had several lung nodules, which diminished in size upon 131I treatment.
  • Fine needle aspiration biopsy of the paraspinal mass resulted in a diagnosis of metastatic squamous cell carcinoma.
  • Histologic evaluation of the lung nodules and pleura-based mass revealed areas of follicular carcinoma intermixed with a various patterns of undifferentiated carcinoma.
  • The paraspinal and kidney mass consisted entirely of anaplastic tumor, including areas of squamoid differentiation.
  • CONCLUSION: In patients with a history of DTC who develop a rapidly growing mass elsewhere, a possibility of metastatic DTC with anaplastic transformation must be considered.
  • [MeSH-major] Carcinoma / diagnosis. Carcinoma, Squamous Cell / diagnosis. Kidney Neoplasms / secondary. Lung Neoplasms / secondary. Spinal Neoplasms / secondary. Thyroid Neoplasms / diagnosis
  • [MeSH-minor] Aged. Biopsy, Fine-Needle / methods. Diagnosis, Differential. Disease Progression. Fatal Outcome. Female. Humans. Sensitivity and Specificity


14. Ito Y, Motoo Y, Yoshida H, Iovanna JL, Nakamura Y, Kuma K, Miyauchi A: High level of tumour protein p53-induced nuclear protein 1 (TP53INP1) expression in anaplastic carcinoma of the thyroid. Pathology; 2006 Dec;38(6):545-7
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  • [Title] High level of tumour protein p53-induced nuclear protein 1 (TP53INP1) expression in anaplastic carcinoma of the thyroid.
  • In this study, we investigated TP531NP1 expression in human thyroid neoplasms.
  • METHODS: We immunohistochemically investigated TP531NP1 in 197 cases of various thyroid neoplasms.
  • All 39 (20 minimally invasive and 19 widely invasive) follicular carcinomas and 20 adenomas were negative for or expressed only low levels of TP531NP1 except for one widely invasive follicular carcinoma.
  • Of 100 papillary carcinomas, only four (4%) expressed high levels of TP531NP1, and the remaining 96 (96%) were classified into the low group.
  • There were no significant relationships between TP531NP1 expression and clinicopathological features of papillary carcinoma.
  • However, 36 of the 38 (94.7%) anaplastic carcinomas expressed high levels of TP531NP1 and the incidence was significantly higher (p<0.0001) than that in other neoplasms.
  • CONCLUSIONS: These findings suggest that TP531NP1 plays a significant role in the progression of anaplastic carcinoma or contributes to anaplastic transformation from papillary or follicular carcinoma, which is in sharp contrast to findings in previous in vitro and in vivo studies.
  • [MeSH-major] Carcinoma / metabolism. Carrier Proteins / metabolism. Heat-Shock Proteins / metabolism. Thyroid Neoplasms / metabolism
  • [MeSH-minor] Adenoma / metabolism. Adenoma / pathology. Carcinoma, Papillary / pathology. Carcinoma, Papillary, Follicular / metabolism. Carcinoma, Papillary, Follicular / pathology. Gene Expression Regulation, Neoplastic. Humans

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  • (PMID = 17393983.001).
  • [ISSN] 0031-3025
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Carrier Proteins; 0 / Heat-Shock Proteins; 0 / TP53INP1 protein, human
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15. Mehdi G, Ansari HA, Siddiqui SA: Cytology of anaplastic giant cell carcinoma of the thyroid with osteoclast-like giant cells--a case report. Diagn Cytopathol; 2007 Feb;35(2):111-2
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  • [Title] Cytology of anaplastic giant cell carcinoma of the thyroid with osteoclast-like giant cells--a case report.
  • Anaplastic carcinoma of the thyroid is known for its highly aggressive behaviour and rapid spread.
  • We report a case of anaplastic carcinoma of the thyroid with focal presence of osteoclast-like giant cells occurring in an elderly male patient, diagnosed on aspiration cytology.
  • [MeSH-major] Carcinoma, Giant Cell / pathology. Giant Cells / pathology. Osteoclasts / pathology. Thyroid Neoplasms / pathology

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  • (PMID = 17230568.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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16. Koya S, Li Y, McDaniel SA, LoBuglio AF, Krontiras H, Carpenter J, Nabell L, Bland K, Falkson C, Forero A: Safety and effectiveness of dose dense neoadjuvant chemotherapy in patients with stage II/III breast cancer. J Clin Oncol; 2009 May 20;27(15_suppl):e11566

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Safety and effectiveness of dose dense neoadjuvant chemotherapy in patients with stage II/III breast cancer.
  • : e11566 Background: NSABP B-18 randomized women with operable breast cancer to receive chemotherapy (AC) either pre- or postoperatively; in the study there was no significant difference in disease free survival (DFS) or overall survival (OS) among patients in either group.
  • Dose dense adjuvant chemotherapy (ATC) has shown a statistically significant improvement in DFS and OS.
  • Women with newly diagnosed breast cancer, T ≥ 3cm, any N, M0 were enrolled.
  • CONCLUSIONS: Our results show that dose dense neoadjuvant chemotherapy achieves a pCR (breast + node) in about 1/3 of patients (34%) with tolerable toxicity; although the number of patients is limited, our data suggest that triple negative breast cancer seems to be the most sensitive tumor to this regimen.

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  • (PMID = 27964074.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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17. Haas V, Čelakovský P, Brtková J, Hornychová H: Unusual Manifestation of Anaplastic Thyroid Cancer. Acta Medica (Hradec Kralove); 2008;51(4):233-236

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Unusual Manifestation of Anaplastic Thyroid Cancer.
  • The diagnosis of anaplastic thyroid cancer was made after surgery and subsequent histological examination.
  • The histological examination of the lymph nodes identified metastasis of anaplastic thyroid cancer.
  • CONCLUSIONS: The differential diagnosis of diseases affecting deep neck structures can be very difficult.

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  • (PMID = 28113058.001).
  • [ISSN] 1211-4286
  • [Journal-full-title] Acta medica (Hradec Kralove)
  • [ISO-abbreviation] Acta Medica (Hradec Kralove)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Czech Republic
  • [Keywords] NOTNLM ; Anaplastic / Metastasis / Retropharyngeal abscess / Thyroid cancer
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18. Nagaiah G, Fu P, Wasman JK, Cooney MM, Mooney C, Afshin D, Lavertu P, Bokar J, Savvides P, Remick SC, CTRU Research Nurses: Phase II trial of sorafenib (bay 43-9006) in patients with advanced anaplastic carcinoma of the thyroid (ATC). J Clin Oncol; 2009 May 20;27(15_suppl):6058

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Phase II trial of sorafenib (bay 43-9006) in patients with advanced anaplastic carcinoma of the thyroid (ATC).
  • We are conducting an open label, phase II study of sorafenib in patients with biopsy-proven ATC to evaluate if its objective response rate is >20% and to further characterize its safety profile.
  • METHODS: Patients with progressive ATC, after cytotoxic chemotherapy with or without radiation were given sorafenib, on a fixed dosing schedule of 400 mg PO bid on 28-day cycles.
  • Treatment was continued until disease progression, unacceptable toxicity or patient refusal.
  • Two of 15 evaluable patients (13%) have partial response (PR) and 4 patients (27%) have stable disease (SD).
  • One patient died on study with rapidly progressive disease.
  • CONCLUSIONS: Sorafenib demonstrates objective tumor response in the first 15 evaluable and pretreated patients with advanced ATC.

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  • (PMID = 27961935.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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19. Flaherty K, Puzanov I, Sosman J, Kim K, Ribas A, McArthur G, Lee RJ, Grippo JF, Nolop K, Chapman P: Phase I study of PLX4032: Proof of concept for V600E BRAF mutation as a therapeutic target in human cancer. J Clin Oncol; 2009 May 20;27(15_suppl):9000

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Phase I study of PLX4032: Proof of concept for V600E BRAF mutation as a therapeutic target in human cancer.
  • V600E BRAF is the most common kinase mutation in melanoma (60%), also found in colorectal carcinomas (10%), most anaplastic and papillary thyroid carcinomas, and low-grade serous ovarian carcinomas.
  • RESULTS: 54 pts have been enrolled: metastatic melanoma (n=49), thyroid (n=3), rectal (n=1), or ovarian carcinoma (n=1).
  • 5 of the 7 BRAF V600E+ pts treated at ≥ 240 mg BID had tumor regression, up to 83%, with 1 confirmed partial response (PR) and 1 unconfirmed PR (too early); 2 of 4 pts with unknown V600E status had tumor regression, up to 50%, with 1 confirmed PR; 2 BRAF wild-type pts had progressive disease.
  • 3 thyroid cancer pts with V600E mutations have tumor regression (range 9-16%) and are progression-free (4-7 months).
  • These observations confirm that V600E BRAF is a valid therapeutic target in human cancer.

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  • (PMID = 27962338.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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20. Wang HM, Huang YW, Huang JS, Wang CH, Kok VC, Hung CM, Chen HM, Tzen CY: Anaplastic carcinoma of the thyroid arising more often from follicular carcinoma than papillary carcinoma. Ann Surg Oncol; 2007 Oct;14(10):3011-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anaplastic carcinoma of the thyroid arising more often from follicular carcinoma than papillary carcinoma.
  • BACKGROUND: Anaplastic thyroid carcinoma (ATC), a rare and highly malignant tumor, has long been thought to arise from well-differentiated carcinoma (WDC) such as follicular thyroid carcinoma (FTC) and papillary thyroid carcinoma (PTC).
  • The purpose of this study was to test this notion by examining whether and, if so, how often ATC harbors the oncogenes that are commonly associated with WDC, such as RAS in FTC and BRAF in PTC.
  • As to the three ATCs that had coexisted PTCs, mutated BRAF was detected in all PTC components but only in one ATC, while mutated PIK3CA was found in only one PTC component but not in the ATC.
  • [MeSH-major] Adenocarcinoma, Follicular / genetics. Adenocarcinoma, Papillary / genetics. Biomarkers, Tumor / genetics. Carcinoma / genetics. Cell Transformation, Neoplastic / genetics. Neoplasms, Multiple Primary / genetics. Thyroid Neoplasms / genetics
  • [MeSH-minor] Aged. Aged, 80 and over. Base Sequence / genetics. Cell Line, Tumor. Codon / genetics. DNA Mutational Analysis. Exons / genetics. Female. Gene Expression Regulation, Neoplastic / physiology. Humans. Male. Middle Aged. Phosphatidylinositol 3-Kinases / genetics. Polymerase Chain Reaction. Proto-Oncogene Proteins B-raf / genetics. Proto-Oncogene Proteins p21(ras) / genetics. Reverse Transcriptase Polymerase Chain Reaction. Sequence Analysis, DNA. Thyroid Gland / pathology. Thyroid Gland / surgery. Tumor Suppressor Protein p53 / genetics

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  • (PMID = 17638058.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Codon; 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.1.137 / PIK3CA protein, human; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf; EC 3.6.5.2 / Proto-Oncogene Proteins p21(ras)
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21. Sugino K, Ito K: [Anaplastic carcinoma of the thyroid]. Nihon Rinsho; 2006 May 28;Suppl 1:485-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Anaplastic carcinoma of the thyroid].
  • [MeSH-major] Carcinoma. Thyroid Neoplasms
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Combined Modality Therapy. Cytodiagnosis. Diagnostic Imaging. Genes, p53 / genetics. Humans. Mutation. Prognosis. Radiotherapy. Thyroidectomy

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  • (PMID = 16776196.001).
  • [ISSN] 0047-1852
  • [Journal-full-title] Nihon rinsho. Japanese journal of clinical medicine
  • [ISO-abbreviation] Nippon Rinsho
  • [Language] jpn
  • [Publication-type] Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 14
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22. Laco J, Ryska A, Celakovský P: [Anaplastic carcinoma of the thyroid gland with chondrosarcomatous component]. Cesk Patol; 2005 Jan;41(1):34-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Anaplastic carcinoma of the thyroid gland with chondrosarcomatous component].
  • [Transliterated title] Anaplastický karcinom stítné zlázy s chondrosarkomatózní komponentou.
  • Fine needle aspiration cytology was performed with the conclusion of a sarcomatoid variant of anaplastic carcinoma of the thyroid gland; biopsy was recommended.
  • The diagnosis of thyroid anaplastic carcinoma with chondrosarcomatous component was established.
  • [MeSH-major] Carcinoma / pathology. Chondrosarcoma / pathology. Thyroid Neoplasms / pathology

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  • (PMID = 15816122.001).
  • [ISSN] 1210-7875
  • [Journal-full-title] Československá patologie
  • [ISO-abbreviation] Cesk Patol
  • [Language] cze
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Czech Republic
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23. Njim L, Moussa A, Hadhri R, Gassab I, Ben Yahia N, Mahmoudi H, Zakhama A: [Angiomatoid tumor of the thyroid gland: primitive angiosarcoma or variant of anaplastic carcinoma?]. Ann Pathol; 2008 Jun;28(3):221-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Angiomatoid tumor of the thyroid gland: primitive angiosarcoma or variant of anaplastic carcinoma?].
  • [Transliterated title] Tumeur angiomatoïde de la thyroïde: angiosarcome primitif ou variante du carcinome anaplasique?
  • Thyroid gland angiomatoid tumors are an extremely aggressive neoplasms with varied histological patterns and features of endothelial differentiation.
  • The histogenesis of thyroid angiomatoid tumors has been controversial for many years: these tumors may be either a variant of anaplastic carcinoma, or an angiosarcoma.
  • We report a case of thyroid angiomatoid tumor in a 68-year-old woman.
  • We also discuss, through a review of the literature, the pathologic criteria that could be used to distinguish between angiosarcoma and anaplastic carcinoma of the thyroid.
  • [MeSH-major] Carcinoma / pathology. Hemangiosarcoma / pathology. Thyroid Neoplasms / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Epithelial Cells / pathology. Female. Humans. Immunohistochemistry. Keratins / metabolism

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  • (PMID = 18706366.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 68238-35-7 / Keratins
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24. Yamai H, Yoshida T, Toba H, Kira M, Takizawa H, Tangoku A: [A case of anaplastic carcinoma of thyroid administered peroral fluorinated pyrimidine for long-term survival during three years]. Gan To Kagaku Ryoho; 2009 Jun;36(6):1021-4
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  • [Title] [A case of anaplastic carcinoma of thyroid administered peroral fluorinated pyrimidine for long-term survival during three years].
  • We report a case of anaplastic carcinoma of the thyroid administered peroral fluorinated pyrimidine, providing longterm survival during three years.
  • Three years ago, a 70-year-old woman diagnosed with anaplastic carcinoma of the thyroid was admitted for chemoradiation therapy after tumor resection and tracheostomy.
  • [MeSH-major] Antimetabolites, Antineoplastic / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Carcinoma / drug therapy. Oxonic Acid / administration & dosage. Tegafur / administration & dosage. Thyroid Neoplasms / drug therapy

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  • (PMID = 19542729.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Drug Combinations; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 56HH86ZVCT / Uracil; 5VT6420TIG / Oxonic Acid; 1-UFT protocol
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25. Sherman EJ, Fury MG, Tuttle RM, Ghossein R, Stambuk H, Baum M, Lisa D, Su YB, Shaha A, Pfister DG: Phase II study of depsipeptide (DEP) in radioiodine (RAI)-refractory metastatic nonmedullary thyroid carcinoma. J Clin Oncol; 2009 May 20;27(15_suppl):6059

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Phase II study of depsipeptide (DEP) in radioiodine (RAI)-refractory metastatic nonmedullary thyroid carcinoma.
  • : 6059 Background: Historically, systemic therapy for radioactive iodine (RAI)-refractory thyroid cancer has been understudied.
  • In thyroid cancer cell lines, DEP increases expression of both thyroglobulin and the sodium/iodine symporter messenger RNAs, offering the possibility of improved iodine concentrating ability of radioactive iodine (RAI)-resistant tumors.
  • METHODS: Eligible patients (pts) must have progressive, RAI-refractory, recurrent/metastatic, non-medullary, non-anaplastic thyroid cancer; RECIST measurable disease; and adequate organ/marrow function.
  • Exclusionary criteria include prior chemotherapy in the recurrent/metastatic setting; cardiac disease or dysfunction; QTc prolongation or co-administration of drugs that prolong the QTc.
  • Evaluation of response: stable disease (10); progression (3); early death (1); unknown/inevaluable (6: 5 - temporary protocol suspension; 1 - withdrew consent).

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  • (PMID = 27961936.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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26. Abelardo E, Jaramillo M, Sheffield E, Tierney P: Anaplastic thyroid carcinoma implantation after fine needle aspiration cytology. J Laryngol Otol; 2007 Mar;121(3):268-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anaplastic thyroid carcinoma implantation after fine needle aspiration cytology.
  • We report the case of a 59-year-old man with a two-month history of a fast-growing, left-sided neck mass and a 5 mm nodule over a thyroid mass at the site of fine needle aspiration cytology performed four weeks earlier.
  • Histopathological studies confirmed anaplastic carcinoma of the thyroid and cutaneous needle track seeding of the primary tumour.
  • The patient succumbed to extensive disease 10 weeks after initial diagnosis.
  • To our knowledge, this is a rare report of implantation of anaplastic thyroid carcinoma along the track of fine needle aspiration.
  • [MeSH-major] Biopsy, Fine-Needle / adverse effects. Carcinoma / pathology. Head and Neck Neoplasms / secondary. Neoplasm Seeding. Skin Neoplasms / secondary. Thyroid Neoplasms / pathology

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  • (PMID = 17040599.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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27. Westhoff CC, Karakas E, Dietz C, Barth PJ: Intrathyroidal hematopoiesis: a rare histological finding in an otherwise healthy patient and review of the literature. Langenbecks Arch Surg; 2008 Sep;393(5):745-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intrathyroidal hematopoiesis: a rare histological finding in an otherwise healthy patient and review of the literature.
  • BACKGROUND AND AIMS: Multinodular goiter represents the most common thyroid disease in Europe and the United States.
  • Calcifications have also been detected by microscopic investigation of thyroid tissue.
  • However, true bone formation is uncommon and to date only two cases of metaplastic bone formation with extramedullary hematopoiesis in the thyroid have been reported in the literature.
  • RESULTS: We report the third case of metaplastic bone formation with foci of hematopoietic tissue in the thyroid gland.
  • CONCLUSION: Isolated extramedullary hematopoiesis seems to be more frequent in the thyroid gland than metaplastic bone formation with hematopoiesis, particularly in older people with underlying hematologic disorders.
  • It also represents an important differential diagnosis of anaplastic carcinoma of the thyroid, particularly in intra-operative frozen sections and fine-needle aspiration biopsy.

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  • (PMID = 18299884.001).
  • [ISSN] 1435-2451
  • [Journal-full-title] Langenbeck's archives of surgery
  • [ISO-abbreviation] Langenbecks Arch Surg
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 15
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28. Brose MS, Troxel AB, Redlinger M, Harlacker K, Redlinger C, Chalian AA, Flaherty KT, Loevner LA, Mandel SJ, O'Dwyer PJ: Effect of BRAF&lt;sup&gt;V600E&lt;/sup&gt; on response to sorafenib in advanced thyroid cancer patients. J Clin Oncol; 2009 May 20;27(15_suppl):6002

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effect of BRAF<sup>V600E</sup> on response to sorafenib in advanced thyroid cancer patients.
  • : 6002 Background: We are conducting an open-label phase II study of sorafenib in patients with metastatic, iodine-refractory thyroid carcinoma.
  • Histological subtypes include papillary (PTC): 25 pts (47%); follicular/Hürthle Cell (FTC): 19 pts (36%); medullary: 4 pts (8%), and poorly differentiated/anaplastic: 5 pts (9%).
  • CONCLUSIONS: Sorafenib has activity in patients with advanced thyroid cancer with an overall PFS of 84 wks.

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  • (PMID = 27962409.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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29. Behlendorf T, Voigt W, Mueller T, Jordan K, Arnold D, Schmoll H: Activity of mTOR-Inhibitor Rad001 (everolimus) in differentiated and anaplastic thyroid cancer cell lines. J Clin Oncol; 2009 May 20;27(15_suppl):e14608

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Activity of mTOR-Inhibitor Rad001 (everolimus) in differentiated and anaplastic thyroid cancer cell lines.
  • : e14608 Background: Recent data suggest that aberrant activation of PIK3/AKT-pathway and mTOR are involved in the development of thyroid cancer, particularly of anaplastic (ATC) and follicular (FTC) subtype.
  • Therefore, mTOR could be a potential treatment target in thyroid cancer.
  • METHODS: To asses the potential role of mTOR as target for the treatment of thyroid cancer, two human ATC cell lines SW1736 and 8505C, the papillary thyroid cancer (PTC) cell line BCPAP and the FTC cell line FTC133 were exposed for 96h to increasing concentrations of the mTOR inhibitor RAD001 (Everolimus, kindly provided by Novartis, Switzerland).
  • CONCLUSION: RAD001 exerted interesting preclinical activity in two differentiated thyroid cancer cell lines.
  • Mainly additive drug interaction in thyroid cancer cell lines was observed for combinations with CDDP and DOX.
  • At least for differentiated thyroid cancer mTOR-inhibition appeared promising, further evaluation in thyroid cancer seems warranted.

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  • (PMID = 27964164.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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30. Collin AC, Chekaroua K, Delaporte T, Droz JP, Peix JL, Delay E: [Anaplastic thyroid carcinoma: aggressive radical resection and cervical reconstruction. A case report]. Ann Chir; 2006 Dec;131(10):631-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Anaplastic thyroid carcinoma: aggressive radical resection and cervical reconstruction. A case report].
  • [Transliterated title] Chirurgie d'exérèse élargie et reconstruction cervicale pour cancer anaplasique de la thyroïde. A propos d'un cas.
  • STUDY AIM: Anaplastic carcinoma of the thyroid is a rare but highly malignant tumor.
  • PATIENT AND METHODS: We present the case of a patient treated in 1996 for an anaplasic thyroid carcinoma with cervical cutaneous invasion.
  • CONCLUSION: Anaplastic carcinoma is one of more aggressive neoplasm affecting humans.
  • [MeSH-major] Carcinoma / surgery. Neck Dissection / methods. Reconstructive Surgical Procedures / methods. Thyroid Neoplasms / surgery. Thyroidectomy / methods
  • [MeSH-minor] Chemotherapy, Adjuvant. Disease-Free Survival. Female. Follow-Up Studies. Humans. Middle Aged. Muscle, Skeletal / transplantation. Radiotherapy, Adjuvant. Skin Transplantation / methods

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  • (PMID = 16824476.001).
  • [ISSN] 0003-3944
  • [Journal-full-title] Annales de chirurgie
  • [ISO-abbreviation] Ann Chir
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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31. Ha HT, Lee JS, Urba S, Koenig RJ, Sisson J, Giordano T, Worden FP: Phase II trial evaluating imatinib (I) in patients (pts) with anaplastic thyroid carcinoma (ATC). J Clin Oncol; 2009 May 20;27(15_suppl):6057

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Phase II trial evaluating imatinib (I) in patients (pts) with anaplastic thyroid carcinoma (ATC).
  • : 6057 Background: There is no standard treatment for ATC.
  • Affymetrix gene chip showed PDGFR overexpression in ATC.
  • In p53 mutated/deficient ATC cell lines, c-Abl is overexpressed, and selective inhibition of c-Abl resulted in cytostatic effect. (I) inhibits tyrosine kinase activity of Bcr-Abl and PDGF.
  • We hypothesize that ATC that overexpress PDGFR or Abl will respond to (I).
  • METHODS: Pts ≥ 18 years old with histologically confirmed ATC, overexpressing PDGFR or c-Abl by immunohistochemistry who had measurable disease were eligible.
  • Pts with complete response (CR)/partial responses (PR)/stable disease (SD) were treated until disease progression.
  • At baseline, 4/11 pts (36%) had locoregional disease, 5/11 pts (45%) had distant metastases, and 2/11 pts (18%) had both.
  • CONCLUSIONS: (I) appears to have activity in advanced ATC and is well tolerated.
  • Due to difficulty of accruing pts with a rare malignancy at a single institution, investigation of (I) in ATC may be warranted in a multi-institution setting.

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  • (PMID = 27961934.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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32. Tollier C, Fusier I, Husson MC: [ATC and EphMRA classifications: evolution from 1996 to 2003 and comparative analysis]. Therapie; 2005 Jan-Feb;60(1):47-56
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [ATC and EphMRA classifications: evolution from 1996 to 2003 and comparative analysis].
  • [Transliterated title] Classifications ATC et EphMRA: evolution entre 1996 et 2003 et analyse comparative.
  • The "Hospital National Center of Drugs Information" (CNHIM) has integrated ATC (Anatomical Therapeutic Chemical) and EphMRA (European Pharmaceutical Marketing Research Association) classifications into its "Thériaque" database and has given the ATC official status in France by publishing a French translation.
  • The objective of this article was to analyse the evolution of these two classification systems between 1996 and 2003, and to compare their allocations (of codes) with those for the drugs present in Thériaque in January 2002.
  • The ATC comprises 14 principal groups and five levels of hierarchy, while the EphMRA comprises 16 principal groups and three to four levels.
  • In Thériaque, the ATC is linked to active substances and drugs, and the EphMRA to drugs.
  • Each year, the two classification systems evolve in terms of addition, suppression, modification and subdivision.
  • Two principal differences are evident in the allocations in Thériaque (class EphMRA K "Hospital solutions" versus class ATC B "Blood and blood forming organ"; class EphMRA T "Diagnostic agents" versus class ATC V "Various").
  • [MeSH-major] Drug Information Services / trends. Pharmaceutical Preparations / classification

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  • (PMID = 15929473.001).
  • [ISSN] 0040-5957
  • [Journal-full-title] Thérapie
  • [ISO-abbreviation] Therapie
  • [Language] fre
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Pharmaceutical Preparations
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33. John U, Baumeister SE, Völzke H, Grabe HJ, Freyberger HJ, Alte D: Estimation of psycholeptic and psychoanaleptic medicine use in an adult general population sample using the Anatomical Therapeutic Chemical classification. Int J Methods Psychiatr Res; 2008;17(4):220-31
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  • [Title] Estimation of psycholeptic and psychoanaleptic medicine use in an adult general population sample using the Anatomical Therapeutic Chemical classification.
  • Medicines taken during the past seven days were assessed from the medicine packages or self-reports and classified according to the Anatomical Therapeutic Chemical (ATC) classification developed by the World Health Organization.
  • It is concluded that considerable proportions of individuals with current PM use exist although lower than may be expected on the basis of the number of individuals with mental disorder in the general population.
  • [MeSH-major] Central Nervous System Stimulants / therapeutic use. Mass Screening / statistics & numerical data. Psychotropic Drugs / therapeutic use

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  • (PMID = 18792082.001).
  • [ISSN] 1049-8931
  • [Journal-full-title] International journal of methods in psychiatric research
  • [ISO-abbreviation] Int J Methods Psychiatr Res
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Central Nervous System Stimulants; 0 / Psychotropic Drugs
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34. Tazbir J, Dedecjus M, Kaurzel Z, Lewiński A, Brzeziński J: Selective embolization of thyroid arteries (SETA) as a palliative treatment of inoperable anaplastic thyroid carcinoma (ATC). Neuro Endocrinol Lett; 2005 Aug;26(4):401-6
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  • [Title] Selective embolization of thyroid arteries (SETA) as a palliative treatment of inoperable anaplastic thyroid carcinoma (ATC).
  • OBJECTIVES: Anaplastic thyroid carcinoma (ATC) is one of the most aggressive solid tumors in humans.
  • Despite intense application of multimodality of treatment with surgery and/or external beam radiotherapy and chemotherapy, the survival rates remain low--generally the mean survival is about six (6) months after diagnosis.
  • Rapid development--particularly over the last decade--of interventional radiology, provides methodology that allows examining thyroid arterial embolization as an alternative approach to ablating thyroid tissue.
  • The aim of the present study was to evaluate selective embolization of the thyroid arteries (SETA) as a possible alternative for the palliative treatment of advanced, inoperable ATC.
  • PATIENTS AND METHODS: The study group comprised five (5) patients with advanced stage of inoperable ATC.
  • All the patients underwent SETA of the superior and/or inferior thyroid arteries.
  • After SETA, selective angiography of thyroid arteries was performed to ensure that the targeted arteries were completely occluded.
  • CONCLUSIONS: The results of the present study suggest that SETA is minimally invasive and save method of palliative treatment of ATC and, as such, may be recommended in cases of intractable hemorrhage and pain caused by ATC progression.
  • [MeSH-major] Carcinoma / therapy. Embolization, Therapeutic / methods. Palliative Care. Thyroid Gland / blood supply. Thyroid Neoplasms / therapy

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  • (PMID = 16136001.001).
  • [ISSN] 0172-780X
  • [Journal-full-title] Neuro endocrinology letters
  • [ISO-abbreviation] Neuro Endocrinol. Lett.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Sweden
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35. Glover L: Certified athletic trainers. Minn Med; 2010 Dec;93(12):43-5
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  • [Title] Certified athletic trainers.
  • Certified athletic trainers optimize people's ability to participate in athletics or activities of work and life.
  • Athletic training encompasses the prevention, examination and assessment, treatment, and rehabilitation of emergent, acute, subacute, and chronic neuromusculoskeletal conditions.
  • Certified athletic trainers play a key role in health care delivery today, and that role is expected to evolve and grow in the future.
  • This article describes what certified athletic trainers do, outlines their educational and certification requirements, and describes the ways they work in different settings-from the sidelines to industry to medical clinics.
  • [MeSH-major] Athletic Injuries / prevention & control. Athletic Injuries / rehabilitation. Certification. Physical Education and Training

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  • (PMID = 21265420.001).
  • [ISSN] 0026-556X
  • [Journal-full-title] Minnesota medicine
  • [ISO-abbreviation] Minn Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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36. Roche B, Larroumets G, Dejax C, Kwiatkowsi F, Desbiez F, Thieblot P, Tauveron I: Epidemiology, clinical presentation, treatment and prognosis of a regional series of 26 anaplastic thyroid carcinomas (ATC). Comparison with the literature. Ann Endocrinol (Paris); 2010 Feb;71(1):38-45
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  • [Title] Epidemiology, clinical presentation, treatment and prognosis of a regional series of 26 anaplastic thyroid carcinomas (ATC). Comparison with the literature.
  • OBJECTIVE: The aim of this study is to retrospectively describe the epidemiological and clinical features, therapeutic modalities, prognostic factors and survival figures in a population of patients with anaplastic thyroid carcinoma (ATC) observed in Auvergne, France.
  • MATERIAL AND METHODS: The analysis was conducted based on a computer database containing a regional register recorded by health professionals treating ATC.
  • RESULTS: Of the 1500 cancers observed over 16 years, 26 were identified as ATC.
  • The male/female ratio was 1/2.7 and the average age: 72.1; 76.9% of the cases had thyroid medical history, average tumor size at diagnosis was 7.35 cm with N1 in the course of illness in 61.5% of cases, M1 in 34.6% of cases.
  • [MeSH-major] Carcinoma / therapy. Thyroid Neoplasms / therapy

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  • [Copyright] Copyright (c) 2009 Elsevier Masson SAS. All rights reserved.
  • (PMID = 19959159.001).
  • [ISSN] 0003-4266
  • [Journal-full-title] Annales d'endocrinologie
  • [ISO-abbreviation] Ann. Endocrinol. (Paris)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] France
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37. Fothergill S, Loft S, Neal A: ATC-lab(Advanced): an air traffic control simulator with realism and control. Behav Res Methods; 2009 Feb;41(1):118-127
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  • [Title] ATC-lab(Advanced): an air traffic control simulator with realism and control.
  • ATC-lab(Advanced) is a new, publicly available air traffic control (ATC) simulation package that provides both realism and experimental control.
  • ATC-lab(Advanced) simulations are realistic to the extent that the display features (including aircraft performance) and the manner in which participants interact with the system are similar to those used in an operational environment.
  • Experimental control allows researchers to standardize air traffic scenarios, control levels of realism, and isolate specific ATC tasks.
  • Importantly, ATC-lab(Advanced) also provides the programming control required to cost effectively adapt simulations to serve different research purposes without the need for technical support.
  • In addition, ATC-lab(Advanced) includes a package for training participants and mathematical spreadsheets for designing air traffic events.
  • Preliminary studies have demonstrated that ATC-lab(Advanced) is a flexible tool for applied and basic research.

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  • (PMID = 19182131.001).
  • [ISSN] 1554-351X
  • [Journal-full-title] Behavior research methods
  • [ISO-abbreviation] Behav Res Methods
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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38. Schiff MA, Mack CD, Polissar NL, Levy MR, Dow SP, O'Kane JW: Soccer injuries in female youth players: comparison of injury surveillance by certified athletic trainers and internet. J Athl Train; 2010 May-Jun;45(3):238-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Soccer injuries in female youth players: comparison of injury surveillance by certified athletic trainers and internet.
  • OBJECTIVE: To determine whether certified athletic trainers (ATs) and parental, Internet-based surveys provided comparable data for identifying soccer injuries.
  • MAIN OUTCOME MEASURE(S): We compared the data provided by ATs attending 1 soccer practice per week with a weekly soccer-parent, Internet-based system.
  • Players sustained 17 overuse injuries (35% knee, 29% lower leg) reported by either system, with 35% reported by ATs and 100% by Internet-based survey.

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  • (PMID = 20446836.001).
  • [ISSN] 1938-162X
  • [Journal-full-title] Journal of athletic training
  • [ISO-abbreviation] J Athl Train
  • [Language] ENG
  • [Grant] United States / NIAMS NIH HHS / AR / R21 AR053371; United States / NIAMS NIH HHS / AR / R21AR053371
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2865961
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39. Stimac D, Culig J, Vukusić I, Sostar Z, Tomić S, Bucalić M: Outpatient utilization patterns of the six main ATC drug groups in Republic of Croatia, city of Zagreb, and Croatia counties in 2004. Coll Antropol; 2009 Dec;33(4):1197-204

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Outpatient utilization patterns of the six main ATC drug groups in Republic of Croatia, city of Zagreb, and Croatia counties in 2004.
  • Zagreb Institute of Public Health in collaboration with the Croatian Drug Agency collected and analyzed data on outpatient utilization of the six main Anatomic-Therapeutic-Chemical (ATC) drug groups.

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  • (PMID = 20102069.001).
  • [ISSN] 0350-6134
  • [Journal-full-title] Collegium antropologicum
  • [ISO-abbreviation] Coll Antropol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study
  • [Publication-country] Croatia
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40. Mensch J, Crews C, Mitchell M: Competing perspectives during organizational socialization on the role of certified athletic trainers in high school settings. J Athl Train; 2005 Oct-Dec;40(4):333-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Competing perspectives during organizational socialization on the role of certified athletic trainers in high school settings.
  • CONTEXT: When certified athletic trainers (ATCs) enter a workplace, their potential for professional effectiveness is affected by a number of factors, including the individual's ability to put acquired knowledge, skills, and attitudes into practice.
  • This ability may be influenced by the preconceived attitudes and expectations of athletes, athletes' parents, athletic directors, physical therapists, physicians, and coaches.
  • OBJECTIVE: To examine the perspectives of high school coaches and ATCs toward the ATC's role in the high school setting by looking at 3 questions:.
  • (1) the athletic training services they received as high school basketball coaches, (2) each coach's expectations of the ATC with whom he or she was working during various phases of the season, and (3) coaches' levels of satisfaction with the athletic training services provided to their team.
  • (1) the ATC's background, (2) the ATC's perceived duties at different phases of the basketball season and his or her relationship with the coach, and (3) other school factors that enhanced or interfered with the ATC's ability to perform duties.
  • Positive communication was identified as a critical component to a good coach-ATC relationship.
  • Coaches must be educated by ATCs to ensure they are receiving qualified athletic training support.

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  • (PMID = 16404456.001).
  • [ISSN] 1062-6050
  • [Journal-full-title] Journal of athletic training
  • [ISO-abbreviation] J Athl Train
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1323296
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41. Sorrentino R, Libertini S, Pallante PL, Troncone G, Palombini L, Bavetsias V, Spalletti-Cernia D, Laccetti P, Linardopoulos S, Chieffi P, Fusco A, Portella G: Aurora B overexpression associates with the thyroid carcinoma undifferentiated phenotype and is required for thyroid carcinoma cell proliferation. J Clin Endocrinol Metab; 2005 Feb;90(2):928-35
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  • [Title] Aurora B overexpression associates with the thyroid carcinoma undifferentiated phenotype and is required for thyroid carcinoma cell proliferation.
  • Loss of mitotic regulation is believed to induce aneuploidy in cancer cells and act as a driving force during the malignant progression.
  • We analyzed Aurora B expression in human thyroid carcinomas.
  • Immunohistochemical analysis of archive samples showed a high expression of Aurora B in anaplastic thyroid carcinomas; conversely, Aurora B expression was not detectable in normal thyroid tissue.
  • Real-time PCR analysis confirmed a strong expression of Aurora B in anaplastic thyroid carcinomas.
  • The block of Aurora B expression induced by RNA interference or by using an inhibitor of Aurora kinase activity significantly reduced the growth of thyroid anaplastic carcinoma cells.
  • [MeSH-major] Protein-Serine-Threonine Kinases / genetics. Thyroid Neoplasms / genetics
  • [MeSH-minor] Animals. Aurora Kinase B. Aurora Kinases. Base Sequence. Carcinoma / enzymology. Carcinoma / genetics. Carcinoma / pathology. Cell Division. Cell Line, Tumor. DNA Primers. Gene Expression Regulation, Enzymologic. Gene Expression Regulation, Neoplastic. Humans. Mice. Mice, Nude. Phenotype. Reverse Transcriptase Polymerase Chain Reaction. Transplantation, Heterologous

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  • (PMID = 15562011.001).
  • [ISSN] 0021-972X
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA Primers; EC 2.7.11.1 / AURKB protein, human; EC 2.7.11.1 / Aurkb protein, mouse; EC 2.7.11.1 / Aurora Kinase B; EC 2.7.11.1 / Aurora Kinases; EC 2.7.11.1 / Protein-Serine-Threonine Kinases
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42. The selection and use of essential medicines. Report of the WHO expert committee, 2005 (including the 14th model list of essential medicines). World Health Organ Tech Rep Ser; 2006;(933):1-119, back cover

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  • Annexes to the main report include the revised version of the WHO Model List of Essential Medicines (the 14th) and a list of all items on the Model List sorted according to their 5-level Anatomical Therapeutic Chemical (ATC) classification codes.
  • [MeSH-major] Drugs, Essential / therapeutic use. Formularies as Topic. World Health Organization

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  • (PMID = 17566509.001).
  • [ISSN] 0512-3054
  • [Journal-full-title] World Health Organization technical report series
  • [ISO-abbreviation] World Health Organ Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Drugs, Essential
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43. Whitson E, Cordova ML, Demchak T, Stemmans CL, King KA: Certified athletic trainers' knowledge and perception of professional preparation involving eating disorders among athletes. J Allied Health; 2006;35(1):18-29
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Certified athletic trainers' knowledge and perception of professional preparation involving eating disorders among athletes.
  • The perceived adequacy of professional preparation about eating disorders and disordered eating has not been evaluated in certified athletic trainers (ATCs).
  • A 42-item Web-based survey was specifically created for this study and disseminated to certified 14,477 members of the National Athletic Trainers' Association (NATA), of whom 13.6% (n = 1,966) responded (mean age of respondents, 31.87 +/- 7.82 yrs).
  • Despite this finding, they also believe it is their responsibility to identify and deal with eating disordered athletes.

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  • (PMID = 16615293.001).
  • [ISSN] 0090-7421
  • [Journal-full-title] Journal of allied health
  • [ISO-abbreviation] J Allied Health
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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44. Milman G, Barnes AJ, Schwope DM, Schwilke EW, Darwin WD, Goodwin RS, Kelly DL, Gorelick DA, Huestis MA: Disposition of cannabinoids in oral fluid after controlled around-the-clock oral THC administration. Clin Chem; 2010 Aug;56(8):1261-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Disposition of cannabinoids in oral fluid after controlled around-the-clock oral THC administration.
  • METHODS: To characterize cannabinoid disposition in oral fluid, we administered around-the-clock oral Delta(9)-tetrahydrocannabinol (THC) (Marinol) doses to 10 participants with current daily cannabis use.
  • Samples were extracted with multiple elution solvents from a single SPE column and analyzed by 2-dimensional GC-MS with electron-impact ionization for THC, 11-hydroxy-THC (11-OH-THC), cannabidiol, and cannabinol and negative chemical ionization for 11-nor-9-carboxy-THC (THCCOOH).

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  • (PMID = 20530732.001).
  • [ISSN] 1530-8561
  • [Journal-full-title] Clinical chemistry
  • [ISO-abbreviation] Clin. Chem.
  • [Language] ENG
  • [Grant] United States / Intramural NIH HHS / / ZIA DA000412-13; United States / Intramural NIH HHS / / ZIA DA000413-13; United States / PHS HHS / / HHSN271200599091; United States / NIDA NIH HHS / DA / N01DA-5-9909
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 7J8897W37S / Dronabinol
  • [Other-IDs] NLM/ NIHMS317054; NLM/ PMC3171507
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45. Weidner TG, Henning JM: Importance and applicability of approved clinical instructor standards and criteria to certified athletic trainers in different clinical education settings. J Athl Train; 2005 Oct-Dec;40(4):326-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Importance and applicability of approved clinical instructor standards and criteria to certified athletic trainers in different clinical education settings.
  • CONTEXT: For optimal clinical education of athletic training students, Clinical Instructor Educators and program directors need to proactively select, train, and evaluate their Approved Clinical Instructors (ACIs).
  • OBJECTIVE: To assess the relative importance and applicability of ACI standards to certified athletic trainers employed in different athletic training clinical education settings.
  • CONCLUSIONS: The Weidner and Henning standards are considered to be important and applicable across a variety of athletic training clinical education settings.

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  • (PMID = 16404455.001).
  • [ISSN] 1062-6050
  • [Journal-full-title] Journal of athletic training
  • [ISO-abbreviation] J Athl Train
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1323295
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46. Brumels K, Beach A: Professional role complexity and job satisfaction of collegiate certified athletic trainers. J Athl Train; 2008 Jul-Aug;43(4):373-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Professional role complexity and job satisfaction of collegiate certified athletic trainers.
  • OBJECTIVE: To examine whether certified athletic trainers (ATs) employed at the collegiate level experienced professional role complexities, and if so, what effect those complexities had upon their job satisfaction and intent to leave a current position or the profession.

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  • [Cites] Nurs Health Sci. 2001 Sep;3(3):161-72 [11882192.001]
  • [Cites] Med Educ. 2002 Jun;36(6):543-9 [12047669.001]
  • [Cites] J Psychol. 2002 Mar;136(2):195-213 [12081094.001]
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  • (PMID = 18668170.001).
  • [ISSN] 1938-162X
  • [Journal-full-title] Journal of athletic training
  • [ISO-abbreviation] J Athl Train
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2474817
  • [Keywords] NOTNLM ; role ambiguity / role conflict / role overload
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47. Mazerolle SM, Scruggs IC, Casa DJ, Burton LJ, McDermott BP, Armstrong LE, Maresh CM: Current knowledge, attitudes, and practices of certified athletic trainers regarding recognition and treatment of exertional heat stroke. J Athl Train; 2010 Mar-Apr;45(2):170-80
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Current knowledge, attitudes, and practices of certified athletic trainers regarding recognition and treatment of exertional heat stroke.
  • CONTEXT: Previous research has indicated that despite awareness of the current literature on the recommended prevention and care of exertional heat stroke (EHS), certified athletic trainers (ATs) acknowledge failure to follow those recommendations.
  • RESULTS: Although most ATs (77.1%) have read the current National Athletic Trainers' Association position statement on heat illness, only 18.6% used rectal thermometers to assess core body temperature to recognize EHS, and 49.7% used cold-water immersion to treat EHS.
  • Athletic trainers perceived rectal thermometers as the most valid temperature assessment device when compared with other assessment devices (P <or= .05), but they used oral thermometers as the primary assessment tool (49.1%).
  • [MeSH-major] Health Knowledge, Attitudes, Practice. Heat Stroke / diagnosis. Heat Stroke / therapy. Physical Education and Training / manpower

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  • (PMID = 20210621.001).
  • [ISSN] 1938-162X
  • [Journal-full-title] Journal of athletic training
  • [ISO-abbreviation] J Athl Train
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2838469
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48. Aggarwal AN, Agarwal R, Gupta D: Automatic tube compensation as an adjunct for weaning in patients with severe neuroparalytic snake envenomation requiring mechanical ventilation: a pilot randomized study. Respir Care; 2009 Dec;54(12):1697-702

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Automatic tube compensation as an adjunct for weaning in patients with severe neuroparalytic snake envenomation requiring mechanical ventilation: a pilot randomized study.
  • OBJECTIVE: This study aimed to evaluate if the combination of pressure-support ventilation (PSV) and automatic tube compensation (ATC) is superior to PSV alone in weaning patients with severe neurotoxic snake envenoming receiving mechanical ventilation.
  • METHODS: Forty-one patients on volume controlled continuous mandatory ventilation were randomized to weaning with PSV alone (PSV group, 18 patients) or PSV plus ATC (ATC group, 23 patients).
  • The ATC group additionally, received inspiratory ATC at 100% through a ventilator-software-driven algorithm.
  • Median duration of weaning was significantly shorter in the ATC group than in the PSV group (8 h, 95% confidence interval 6.6-9.4 h vs 12 h, 95% confidence interval 9.9-14.1 h, P = .03 via log-rank test).
  • Median duration of mechanical ventilation and intensive-care-unit stay were similar between the PSV and the ATC groups (36.5 h, IQR 23.0-52.0 h vs 41.0 h, IQR 25.0-48.0 h, and 3.5 d, IQR 2-4 d vs 3 d, IQR 2-4 d, respectively).
  • Three patients in the PSV group and none in the ATC group developed pneumonia (P = .08).
  • CONCLUSION: The addition of ATC to a standard PSV-based weaning protocol significantly shortened time needed to wean patients with severe neurotoxic snake envenoming, without changing the duration of medical care, morbidity, or mortality.

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  • (PMID = 19961636.001).
  • [ISSN] 0020-1324
  • [Journal-full-title] Respiratory care
  • [ISO-abbreviation] Respir Care
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
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49. Cohen J, Shapiro M, Grozovski E, Fox B, Lev S, Singer P: Prediction of extubation outcome: a randomised, controlled trial with automatic tube compensation vs. pressure support ventilation. Crit Care; 2009;13(1):R21
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prediction of extubation outcome: a randomised, controlled trial with automatic tube compensation vs. pressure support ventilation.
  • Some patients may not tolerate the trial because of the respiratory load imposed by the endotracheal tube, so varying levels of respiratory support are widely used during the trial.
  • Automatic tube compensation (ATC), specifically developed to overcome the imposed work of breathing because of artificial airways, appears ideally suited for the weaning process.
  • We further evaluated the use of ATC in this setting.
  • METHODS: In a prospective study, patients who had received mechanical ventilation for more than 24 hours and met defined criteria for a weaning trial, underwent a one-hour spontaneous breathing trial with either ATC (n = 87) or pressure support ventilation (PSV; n = 93).
  • In addition, we measured the frequency/tidal volume ratio (f/VT) both with (ATC-assisted) and without ATC (unassisted-f/VT) at the start of the breathing trial as a pretrial predictor of extubation outcome.
  • RESULTS: There were no significant differences in any of the baseline characteristics between the two groups apart from a significantly higher Acute Physiology and Chronic Health Evaluation (APACHE) II score in the ATC group (p = 0.009).
  • In the PSV group, 13 of 93 (14%) patients failed the breathing trial compared with only 6 of 87 (6%) in the ATC group; this observed 8% difference, however, did not reach statistical significance (p = 0.12).
  • The rate of reintubation was not different between the groups (total group = 17.3%; ATC = 18.4% vs. PSV = 12.9%, p = 0.43).
  • The percentage of patients who remained extubated for more than 48 hours was similar in both groups (ATC = 74.7% vs. PSV = 73.1%; p = 0.81).
  • This represented a positive predictive value for PSV of 0.85 and ATC of 0.80 (p = 0.87).
  • Finally, the ATC-assisted f/VT was found to have a significant contribution in predicting successful liberation and extubation compared with the non-significant contribution of the unassisted f/VT (unassisted f/VT, p = 0.19; ATC-assisted f/VT, p = 0.005).
  • CONCLUSIONS: This study confirms the usefulness of ATC during the weaning process, being at least as effective as PSV in predicting successful extubation outcome and significantly improving the predictive value of the f/VT.

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  • (PMID = 19236688.001).
  • [ISSN] 1466-609X
  • [Journal-full-title] Critical care (London, England)
  • [ISO-abbreviation] Crit Care
  • [Language] eng
  • [Databank-accession-numbers] ISRCTN/ ISRCTN16080446
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2688139
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50. Ndong GP, Adam G, Mouala C, Faucherre V, Kouely PN, Sibeoni J, Courpotin C: [National coordination of the ambulatory treatment centers (ATC) in Gabon: a new process to conduct the scaling up of care for people living with HIV-AIDS]. Sante; 2008 Apr-Jun;18(2):97-102
MedlinePlus Health Information. consumer health - HIV/AIDS.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [National coordination of the ambulatory treatment centers (ATC) in Gabon: a new process to conduct the scaling up of care for people living with HIV-AIDS].
  • [Transliterated title] La coordination nationale des centres de traitement ambulatoire au Gabon : une expérience novatrice de décentralisation opérationnelle de la prise en charge du VIH-sida.
  • Starting from the experience conducted on three ambulatory treatment centers (ATC) [Libreville, Franceville, Port-Gentil] in collaboration with the French Red Cross, Gabonese authorities decided the scaling up of HIV patients' care to seven new ATC at a national level.
  • Technical and medical supervision of the ten ATC were attributed to the French Red Cross by Gabonese authorities with the financial support of the French Agency for Development.
  • The ten ATC, founded by the ministry of public health, were then organized within a network under the responsibility of a national coordination.
  • This structure created in September 2007 represents the main organism to conduct, evaluate and follow-up activities and functioning of the ten ATC.
  • In June 2007, 5 ATC were in function taking care of 7,062 PLWA.
  • In November 2008, 9 ATC were in function taking care of 8,174 PLWA.
  • [MeSH-minor] Anti-Retroviral Agents / therapeutic use. France. Gabon. Humans. Quality of Life

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  • (PMID = 19188133.001).
  • [ISSN] 1157-5999
  • [Journal-full-title] Santé (Montrouge, France)
  • [ISO-abbreviation] Sante
  • [Language] fre
  • [Publication-type] Comparative Study; English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Anti-Retroviral Agents
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51. Cohen JD, Shapiro M, Grozovski E, Lev S, Fisher H, Singer P: Extubation outcome following a spontaneous breathing trial with automatic tube compensation versus continuous positive airway pressure. Crit Care Med; 2006 Mar;34(3):682-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extubation outcome following a spontaneous breathing trial with automatic tube compensation versus continuous positive airway pressure.
  • OBJECTIVE: We hypothesized that the additional use of automatic tube compensation (ATC) during a spontaneous breathing trial with continuous positive airway pressure (CPAP), by minimizing respiratory work, would result in more patients undergoing successful extubation.
  • INTERVENTIONS: Patients were randomized to undergo a 1-hr spontaneous breathing trial with either ATC with CPAP (ATC group, n=51) or CPAP alone (CPAP group, n=48).
  • ATC was provided by commercially available mechanical ventilators.
  • There was a trend for more patients in the ATC group to tolerate the breathing trial and undergo extubation (96% vs. 85%; p=.08).
  • The rate of reintubation was 14% in the ATC group and 24% in the CPAP group (p=.28).
  • Significantly more patients in the ATC group thus met the criteria for successful extubation (82% vs. 65%; p=0.04).
  • CONCLUSION: This is the largest single-center study to date assessing the use of commercially available ATC and suggests that this might be a useful mode for performing a spontaneous breathing trial preceding extubation in a general intensive care population.

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  • [CommentIn] Crit Care Med. 2006 Nov;34(11):2867; author reply 2867 [17053584.001]
  • (PMID = 16505653.001).
  • [ISSN] 0090-3493
  • [Journal-full-title] Critical care medicine
  • [ISO-abbreviation] Crit. Care Med.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
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52. Marra J, Covassin T, Shingles RR, Canady RB, Mackowiak T: Assessment of certified athletic trainers' levels of cultural competence in the delivery of health care. J Athl Train; 2010 Jul-Aug;45(4):380-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Assessment of certified athletic trainers' levels of cultural competence in the delivery of health care.
  • CONTEXT: The concept of culture and its relationship to athletic training beliefs and practices is virtually unexplored.
  • OBJECTIVE: To assess the cultural competence levels of certified athletic trainers (ATs) in their delivery of health care services and to examine the relationship between cultural competence and sex, race/ethnicity, years of athletic training experience, and National Athletic Trainers' Association (NATA) district.
  • SETTING: Certified member database of the NATA.
  • Educators and employers can use these results to help develop diversity training education for ATs and athletic training students.

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  • (PMID = 20617913.001).
  • [ISSN] 1938-162X
  • [Journal-full-title] Journal of athletic training
  • [ISO-abbreviation] J Athl Train
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2902032
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53. Takarabe M, Shigemizu D, Kotera M, Goto S, Kanehisa M: Characterization and classification of adverse drug interactions. Genome Inform; 2010 Jan;22:167-75
MedlinePlus Health Information. consumer health - Medicines.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Characterization and classification of adverse drug interactions.
  • In this study, we further analyzed the obtained drug interaction network by merging drugs into drug categories based on the Anatomical Therapeutic Chemical (ATC) classification.
  • [MeSH-major] Drug Interactions. Drug-Related Side Effects and Adverse Reactions / epidemiology. Pharmaceutical Preparations / classification

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  • (PMID = 20238427.001).
  • [ISSN] 0919-9454
  • [Journal-full-title] Genome informatics. International Conference on Genome Informatics
  • [ISO-abbreviation] Genome Inform
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Pharmaceutical Preparations
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54. WHO Expert Committee: The selection and use of essential medicines. World Health Organ Tech Rep Ser; 2007;(946):1-162, back cover

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Annexes to the main report include the revised version of the WHO Model List of Essential Medicines (the 15th) and a list of all items on the Model List sorted according to their 5-level Anatomical Therapeutic Chemical (ATC) classification codes.

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  • (PMID = 18309920.001).
  • [ISSN] 0512-3054
  • [Journal-full-title] World Health Organization technical report series
  • [ISO-abbreviation] World Health Organ Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Drugs, Essential
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55. Sakji S, Letord C, Dahamna B, Kergourlay I, Pereira S, Joubert M, Darmoni S: Automatic indexing in a drug information portal. Stud Health Technol Inform; 2009;148:112-22
MedlinePlus Health Information. consumer health - Medicines.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Automatic indexing in a drug information portal.
  • OBJECTIVE: The objective of this work is to create a bilingual (French/English) Drug Information Portal (DIP), in a multi-terminological context and to emphasize its exploitation by an ATC automatic indexing allowing having more pertinent information about substances, organs or systems on which drugs act and their therapeutic and chemical characteristics.
  • DIP has created specific functionalities and uses specific drugs terminologies such as the ATC classification which used to automatic index the DIP resources.
  • The ATC automatic indexing provided relevant results in 76% of cases.

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  • (PMID = 19745241.001).
  • [ISSN] 0926-9630
  • [Journal-full-title] Studies in health technology and informatics
  • [ISO-abbreviation] Stud Health Technol Inform
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Pharmaceutical Preparations
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56. WHO Expert Committee: The selection and use of essential medicines. World Health Organ Tech Rep Ser; 2008;(950):backcover, vii-174

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Appendices to the main report include the first WHO Model List of Essential Medicines for Children, a list of all the items it contains sorted according to their 5-level Anatomical Therapeutic Chemical (ATC) classification codes and a summary of medicines to be reviewed before the next meeting of the Subcommittee.
  • [MeSH-major] Drugs, Essential / therapeutic use. World Health Organization

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  • (PMID = 18754303.001).
  • [ISSN] 0512-3054
  • [Journal-full-title] World Health Organization technical report series
  • [ISO-abbreviation] World Health Organ Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article; Technical Report
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Drugs, Essential
  • [Investigator] Al-Fannah JM; Coelho H; Cranswick N; Gilani AU; Gray A; Gupta U; Helali A; Hoppu K; Irs A; Kazembe P; Mehta D; Reidenberg M; Suryawati S; Walters S; Pedersen HB; Chongtrakul P; Zhiping L; Nakamura H; Robertson J; Hill S; Hogerzeil H; Ondari C; Zisovska E; Davies EH; Kearns G; Mattison D; Terlouw D
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57. WHO Expert Committee: The selection and use of essential medicines. World Health Organ Tech Rep Ser; 2009;(958):1-242, back cover

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In addition there is a list of all the items on the Model List sorted according to their Anatomical Therapeutic Chemical (ATC) classification codes.

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  • (PMID = 20560299.001).
  • [ISSN] 0512-3054
  • [Journal-full-title] World Health Organization technical report series
  • [ISO-abbreviation] World Health Organ Tech Rep Ser
  • [Language] eng
  • [Publication-type] Consensus Development Conference; Journal Article; Technical Report
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Dosage Forms; 0 / Drugs, Essential
  • [Number-of-references] 184
  • [Investigator] Al-Fannah JM; Bero LA; Cheraghali AM; Cranswick N; Dodoo AN; Fernandopulle R; Gray A; Henkens M; Hoppu K; Kearns GL; Delgado EJ; Reidenberg MM; Wannmacher L; Zaidi A; Batmanabane G; Hua DY; How CH; Zisovska E; Kozarewicz P; Pedersen HB; Wolman Y; Fauveau V; Doedens W; Hogerzeil HV; Ondari C; Hill S; Ridge A; Akmal R
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58. Yard EE, Collins CL, Comstock RD: A comparison of high school sports injury surveillance data reporting by certified athletic trainers and coaches. J Athl Train; 2009 Nov-Dec;44(6):645-52
MedlinePlus Health Information. consumer health - Sports Injuries.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A comparison of high school sports injury surveillance data reporting by certified athletic trainers and coaches.
  • OBJECTIVE: To examine the feasibility of relying on high school coaches as data reporters in a national, Internet-based sports injury surveillance study, using the same methods that have already proven successful in the National High School Sports-Related Injury Surveillance Study, which calls on certified athletic trainers (ATs) as reporters.
  • SETTING: Eighteen United States high schools PARTICIPANTS: Athletic trainers and varsity coaches for football, boys' and girls' soccer, and boys' and girls' basketball.
  • The reports submitted by ATs and coaches for the same injury had low agreement for diagnosis and time loss, with only 63.2% and 55.3% of pairs, respectively, providing the same response.
  • [MeSH-major] Athletic Injuries / epidemiology. Schools / statistics & numerical data. Sports Medicine / statistics & numerical data

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  • (PMID = 19911092.001).
  • [ISSN] 1938-162X
  • [Journal-full-title] Journal of athletic training
  • [ISO-abbreviation] J Athl Train
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2775367
  • [Keywords] NOTNLM ; injury epidemiology / methodologies
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59. Nucera C, Eeckhoute J, Finn S, Carroll JS, Ligon AH, Priolo C, Fadda G, Toner M, Sheils O, Attard M, Pontecorvi A, Nose V, Loda M, Brown M: FOXA1 is a potential oncogene in anaplastic thyroid carcinoma. Clin Cancer Res; 2009 Jun 1;15(11):3680-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] FOXA1 is a potential oncogene in anaplastic thyroid carcinoma.
  • Here, we investigated the potential role of FOXA1 in human thyroid carcinomas.
  • EXPERIMENTAL DESIGN: We examined the level of FOXA1 expression and gene copy number by immunohistochemistry and fluorescence in situ hybridization, respectively, in a cohort of benign and malignant thyroid tumors.
  • In addition, we examined the role of FOXA1 in the proliferation of an undifferentiated thyroid carcinoma cell line by short hairpin RNA-mediated silencing.
  • RESULTS: We show that FOXA1 is overexpressed in human anaplastic thyroid carcinomas (ATC).
  • In addition, we identify FOXA1 DNA copy number gain within the 14q21.1 locus in both an ATC cell line and human ATC cases.
  • Silencing of FOXA1 in an ATC cell line causes G(1) growth arrest and reduction of cell proliferation.
  • CONCLUSIONS: FOXA1 is overexpressed in aggressive thyroid cancers and involved in cell cycle progression in an ATC cell line.
  • Therefore, FOXA1 may be an important oncogene in thyroid tumorigenesis and a potential new therapeutic target for the treatment of anaplastic thyroid cancers.
  • [MeSH-major] Carcinoma / pathology. Hepatocyte Nuclear Factor 3-alpha / metabolism. Oncogene Proteins / metabolism. Thyroid Neoplasms / pathology

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  • (PMID = 19470727.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CDKN1B protein, human; 0 / FOXA1 protein, human; 0 / Hepatocyte Nuclear Factor 3-alpha; 0 / Intracellular Signaling Peptides and Proteins; 0 / Oncogene Proteins; 0 / RNA, Small Interfering; 147604-94-2 / Cyclin-Dependent Kinase Inhibitor p27
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60. Rodrigues RF, Roque L, Krug T, Leite V: Poorly differentiated and anaplastic thyroid carcinomas: chromosomal and oligo-array profile of five new cell lines. Br J Cancer; 2007 Apr 23;96(8):1237-45
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Poorly differentiated and anaplastic thyroid carcinomas: chromosomal and oligo-array profile of five new cell lines.
  • Information on gene alterations associated to poorly differentiated (PDTC) and anaplastic thyroid carcinomas (ATC) is scarce.
  • Using human cancer cell lines as a tool for gene discovery, we performed a cytogenetic and oligo-array analysis in five new cell lines derived from two PDTC and three ATC.
  • In ATC, downregulation of a specific group of oncosuppressor genes was also observed.
  • Our ATC cell lines presented chromosomal markers of gene amplification, and we were able to identify for the first time the nature of the involved amplicon target genes.
  • TaqMan experiments performed for five amplicon target genes and for two genes, which allowed a clear distinction between ATC and PDTC: CDH13 and PLAU corroborated array results, not only in the cell lines, but also in an additional set of primary 14 PDTC and three ATC.
  • We suggest that our findings may represent new tools for the development of more effective therapies to the hitherto untreatable ATC.
  • [MeSH-major] Chromosome Aberrations. Gene Expression Profiling. Thyroid Neoplasms / genetics


61. Cariou JL: [Composite tissues allotransplantation (CTA). Conclusions]. Ann Chir Plast Esthet; 2007 Oct;52(5):551-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Allotransplantation de tissus composites (ATC). Conclusions.

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  • (PMID = 17766025.001).
  • [ISSN] 0294-1260
  • [Journal-full-title] Annales de chirurgie plastique et esthétique
  • [ISO-abbreviation] Ann Chir Plast Esthet
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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62. Goodman A, Mensch JM, Jay M, French KE, Mitchell MF, Fritz SL: Retention and attrition factors for female certified athletic trainers in the National Collegiate Athletic Association Division I Football Bowl Subdivision setting. J Athl Train; 2010 May-Jun;45(3):287-98
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Retention and attrition factors for female certified athletic trainers in the National Collegiate Athletic Association Division I Football Bowl Subdivision setting.
  • However, little is known about the retention and attrition of female certified athletic trainers (ATs) in certain settings.
  • OBJECTIVE: To gain insight and understanding into the factors and circumstances affecting female ATs' decisions to persist in or leave the National Collegiate Athletic Association Division I Football Bowl Subdivision (NCAA D-I FBS) setting.
  • [MeSH-major] Athletic Injuries. Burnout, Professional. Football / injuries. Personnel Turnover / statistics & numerical data. Sports Medicine / manpower

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  • (PMID = 20446843.001).
  • [ISSN] 1938-162X
  • [Journal-full-title] Journal of athletic training
  • [ISO-abbreviation] J Athl Train
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2865968
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63. Pitney WA: Organizational influences and quality-of-life issues during the professional socialization of certified athletic trainers working in the National Collegiate Athletic Association Division I setting. J Athl Train; 2006 Apr-Jun;41(2):189-95
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Organizational influences and quality-of-life issues during the professional socialization of certified athletic trainers working in the National Collegiate Athletic Association Division I setting.
  • Little is known about the organizational socialization of certified athletic trainers (ATs) in the collegiate context.
  • OBJECTIVE: To discuss the organizational influences and quality-of-life issues as each relates to the professional socialization of ATs working in the National Collegiate Athletic Association Division I setting.
  • SETTING: Participants associated with Division I athletic programs from 4 National Athletic Trainers' Association districts volunteered for the study.
  • PARTICIPANTS: A total of 11 men and 5 women participated in the study, consisting of 14 ATs and 2 athletic directors.
  • The data indicate that the participants in this study were heavily influenced by the bureaucratic tendencies of the Division I athletic organizations in which they worked.

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  • [Cites] J Athl Train. 2000 Apr;35(2):139-44 [16558622.001]
  • [Cites] J Athl Train. 1998 Jan;33(1):54-61 [16558486.001]
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  • [Cites] J Allied Health. 2002 Fall;31(3):131-9 [12227263.001]
  • [Cites] J Adv Nurs. 1997 Feb;25(2):245-56 [9043997.001]
  • (PMID = 16791305.001).
  • [ISSN] 1062-6050
  • [Journal-full-title] Journal of athletic training
  • [ISO-abbreviation] J Athl Train
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1472645
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64. Karabay O, Hosoglu S: Increased antimicrobial consumption following reimbursement reform in Turkey. J Antimicrob Chemother; 2008 May;61(5):1169-71
MedlinePlus Health Information. consumer health - Antibiotics.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The anatomical therapeutic chemical (ATC) classification and the defined daily dose (DDD) methodology were used to calculate antibiotic consumption.
  • [MeSH-major] Anti-Bacterial Agents / therapeutic use. Drug Utilization / trends. Reimbursement Mechanisms / standards

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  • (PMID = 18272511.001).
  • [ISSN] 1460-2091
  • [Journal-full-title] The Journal of antimicrobial chemotherapy
  • [ISO-abbreviation] J. Antimicrob. Chemother.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents
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65. Mazerolle SM, Bruening JE, Casa DJ: Work-family conflict, part I: Antecedents of work-family conflict in national collegiate athletic association division I-A certified athletic trainers. J Athl Train; 2008 Sep-Oct;43(5):505-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Work-family conflict, part I: Antecedents of work-family conflict in national collegiate athletic association division I-A certified athletic trainers.
  • To date, few authors have examined work-family conflict within the athletic training profession.
  • OBJECTIVE: To investigate the occurrence of WFC in certified athletic trainers (ATs) and to identify roots and factors leading to quality-of-life issues for ATs working in the National Collegiate Athletic Association Division I-A setting.

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  • [Cites] J Appl Psychol. 2002 Jun;87(3):427-36 [12090600.001]
  • [Cites] Res Q Exerc Sport. 2007 Jun;78(3):236-47 [17679497.001]
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  • (PMID = 18833313.001).
  • [ISSN] 1938-162X
  • [Journal-full-title] Journal of athletic training
  • [ISO-abbreviation] J Athl Train
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2547870
  • [Keywords] NOTNLM ; job responsibilities / quality of life / work load
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66. Goede A, Dunkel M, Mester N, Frommel C, Preissner R: SuperDrug: a conformational drug database. Bioinformatics; 2005 May 1;21(9):1751-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Furthermore, for selection purposes or for correlation of structural similarity with medical application, the assignment of the Anatomical Therapeutic Chemical (ATC) classification codes to each structure according to the WHO-scheme would be desirable.
  • Here we present a web-query system enabling searches for drug name, synonyms, trade name, trivial name, formula, CAS-number, ATC-code etc.
  • 2D-similarity screening (Tanimoto coefficients) and an automatic 3D-superposition procedure based on conformational representation are implemented.
  • AVAILABILITY: For academic use the system is accessible at http://bioinf.charite.de/superdrug.
  • The retrieval system requires the free browser-plugin 'chime' from MDL for visualization.

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  • (PMID = 15691861.001).
  • [ISSN] 1367-4803
  • [Journal-full-title] Bioinformatics (Oxford, England)
  • [ISO-abbreviation] Bioinformatics
  • [Language] eng
  • [Publication-type] Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Pharmaceutical Preparations
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67. Abu-Khalaf MM, Windsor S, Ebisu K, Salikooti S, Ananthanarayanan G, Chung GG, DiGiovanna MP, Haffty BG, Abrams M, Farber LR, Hsu AD, Reiss M, Zelterman D, Burtness BA: Five-year update of an expanded phase II study of dose-dense and -intense doxorubicin, paclitaxel and cyclophosphamide (ATC) in high-risk breast cancer. Oncology; 2005;69(5):372-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Five-year update of an expanded phase II study of dose-dense and -intense doxorubicin, paclitaxel and cyclophosphamide (ATC) in high-risk breast cancer.
  • OBJECTIVES: This study evaluated the safety and efficacy of dose-dense and -intense sequential doxorubicin (A), paclitaxel (T) and cyclophosphamide (C) as adjuvant therapy for breast cancer (BC) with >or=4 ipsilateral axillary lymph nodes.
  • METHODS: Patients were recruited after BC surgery if >or=4 axillary nodes were involved by metastatic cancer.
  • Sixty-nine (81%) patients are alive, and 59 (69%) patients are alive and free of distant disease at a median follow-up of 5 years.
  • CONCLUSIONS: ATC is a feasible regimen for adjuvant therapy of high-risk BC, with a relatively low rate of relapse at the 5-year follow up.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Breast Neoplasms / drug therapy. Cyclophosphamide / administration & dosage. Doxorubicin / administration & dosage. Paclitaxel / administration & dosage
  • [MeSH-minor] Adult. Aged. Disease-Free Survival. Dose-Response Relationship, Drug. Female. Follow-Up Studies. Humans. Lymphatic Metastasis. Middle Aged. Neoplasm Metastasis. Time Factors

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  • (PMID = 16319508.001).
  • [ISSN] 0030-2414
  • [Journal-full-title] Oncology
  • [ISO-abbreviation] Oncology
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30CA16359
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; P88XT4IS4D / Paclitaxel
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68. Borg MA, Zarb P, Ferech M, Goossens H, ARMed Project Group: Antibiotic consumption in southern and eastern Mediterranean hospitals: results from the ARMed project. J Antimicrob Chemother; 2008 Oct;62(4):830-6
MedlinePlus Health Information. consumer health - Antibiotics.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The surveillance focused primarily on systemic antibiotics used in hospital care, aggregated at the level of the active substance, in accordance with the Anatomic Therapeutic Chemical (ATC) classification.
  • [MeSH-major] Anti-Bacterial Agents / therapeutic use. Drug Utilization / statistics & numerical data

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  • (PMID = 18593724.001).
  • [ISSN] 1460-2091
  • [Journal-full-title] The Journal of antimicrobial chemotherapy
  • [ISO-abbreviation] J. Antimicrob. Chemother.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents
  • [Investigator] Gür D; Ben Redjeb S; Rasslan O; Elnassar Z; Bagatzouni DP; Daoud Z
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69. Wawruch M, Bozekova L, Tisonova J, Raganova A, Lassanova M, Hudec R, Vojtko R, Gazova A, Kriska M: The Slovak Drug Information (Druginfo) Centre during the period 1997-2004. Bratisl Lek Listy; 2005;106(3):133-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • According to the ATC classification the questions were most often related to antiinfective drugs, cardiovascular drugs and psychiatric drugs.

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  • (PMID = 16026149.001).
  • [ISSN] 0006-9248
  • [Journal-full-title] Bratislavské lekárske listy
  • [ISO-abbreviation] Bratisl Lek Listy
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Slovakia
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70. Tlustá E, Ulmanová D, Vitásek Z, Vlcek J: [Consumption of old and new antiepileptic drugs in the Czech Republic in 1999-2004]. Ceska Slov Farm; 2007 Jan;56(1):37-41

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The AEDs utilization was assessed according to ATC/DDD methodology on the fourth and fifth level of the ATC classification and expressed as the number of defined daily doses per 1000 insured per day (DDD/TID).
  • [MeSH-major] Anticonvulsants / therapeutic use

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  • (PMID = 17432281.001).
  • [ISSN] 1210-7816
  • [Journal-full-title] Ceská a Slovenská farmacie : casopis Ceské farmaceutické spolecnosti a Slovenské farmaceutické spolecnosti
  • [ISO-abbreviation] Ceska Slov Farm
  • [Language] cze
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Czech Republic
  • [Chemical-registry-number] 0 / Anticonvulsants
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71. Gurulingappa H, Kolárik C, Hofmann-Apitius M, Fluck J: Concept-based semi-automatic classification of drugs. J Chem Inf Model; 2009 Aug;49(8):1986-92
MedlinePlus Health Information. consumer health - Medicines.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Concept-based semi-automatic classification of drugs.
  • The anatomical therapeutic chemical (ATC) classification system maintained by the World Health Organization provides a global standard for the classification of medical substances and serves as a source for drug repurposing research.
  • Therefore, an IE-based framework is employed to extract terms from free text that express drug's chemical, pharmacological, therapeutic, and systemic effects.
  • The extracted terms are used as features within a ML framework to predict putative ATC class labels for unclassified drugs.
  • The system was tested on a portion of ATC containing drugs with an indication on the cardiovascular system.
  • The presented concept-based classification system outperformed state-of-the-art classification methods based on chemical structure properties.
  • [MeSH-major] Artificial Intelligence. Pharmaceutical Preparations / classification

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  • (PMID = 19663460.001).
  • [ISSN] 1549-9596
  • [Journal-full-title] Journal of chemical information and modeling
  • [ISO-abbreviation] J Chem Inf Model
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Pharmaceutical Preparations
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72. Khan N, Oriuchi N, Higuchi T, Endo K: Review of fluorine-18-2-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) in the follow-up of medullary and anaplastic thyroid carcinomas. Cancer Control; 2005 Oct;12(4):254-60
MedlinePlus Health Information. consumer health - Thyroid Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Review of fluorine-18-2-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) in the follow-up of medullary and anaplastic thyroid carcinomas.
  • BACKGROUND: The goal of posttreatment follow-up for medullary and anaplastic thyroid cancer (MTC and ATC) is the early diagnosis of recurrence or metastases.
  • However, routine follow-up protocols, including physical examination and clinically oriented investigations, are not standardized, and their sensitivity in accurately detecting recurrent or metastatic disease is often suboptimal.
  • METHODS: We review the role of FDG-PET imaging in the follow-up of patients previously treated for MTC and ATC.
  • RESULTS: Based on the encouraging literature data, FDG-PET appears to be useful in detecting recurrent or metastatic disease in patients with MTC and ATC, providing a higher sensitivity (66% to 100%) and specificity (79% to 90%) than conventional imaging methods.
  • CONCLUSIONS: Supporting evidence indicates that FDG-PET has a significant role in the follow-up of patients with MTC and ATC.
  • [MeSH-major] Carcinoma / radionuclide imaging. Carcinoma, Medullary / radionuclide imaging. Fluorodeoxyglucose F18. Radiopharmaceuticals. Thyroid Neoplasms / radionuclide imaging

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  • (PMID = 16258498.001).
  • [ISSN] 1073-2748
  • [Journal-full-title] Cancer control : journal of the Moffitt Cancer Center
  • [ISO-abbreviation] Cancer Control
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
  • [Number-of-references] 45
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73. Mazerolle SM, Bruening JE, Casa DJ, Burton LJ: Work-family conflict, part II: Job and life satisfaction in national collegiate athletic association division I-A certified athletic trainers. J Athl Train; 2008 Sep-Oct;43(5):513-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Work-family conflict, part II: Job and life satisfaction in national collegiate athletic association division I-A certified athletic trainers.
  • However, WFC and its consequences have not yet been fully investigated among certified athletic trainers.
  • OBJECTIVE: To investigate the relationship between WFC and various outcome variables among certified athletic trainers working in National Collegiate Athletic Association Division I-A settings.
  • PATIENTS OR OTHER PARTICIPANTS: A total of 587 athletic trainers (324 men, 263 women) responded to the questionnaire, and 12 (6 men, 6 women) participated in the qualitative portion of the mixed-methods study.

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  • [Cites] J Occup Health Psychol. 2000 Apr;5(2):278-308 [10784291.001]
  • [Cites] J Appl Psychol. 2002 Jun;87(3):427-36 [12090600.001]
  • [Cites] J Nurs Adm. 2002 Dec;32(12):648-54 [12483086.001]
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  • (PMID = 18833314.001).
  • [ISSN] 1938-162X
  • [Journal-full-title] Journal of athletic training
  • [ISO-abbreviation] J Athl Train
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2547871
  • [Keywords] NOTNLM ; attrition / burnout
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74. Smidt D, Torpet LA, Nauntofte B, Heegaard KM, Pedersen AM: Associations between labial and whole salivary flow rates, systemic diseases and medications in a sample of older people. Community Dent Oral Epidemiol; 2010 Oct;38(5):422-35

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Systemic diseases, medications (coded according to the Anatomical Therapeutic Chemical (ATC) Classification System), tobacco and alcohol consumption were registered.
  • New insights into medications and their association with salivary gland function were achieved using the ATC classification system.
  • [MeSH-minor] Age Factors. Aged. Aged, 80 and over. Chi-Square Distribution. Cross-Sectional Studies. Disease. Drug-Related Side Effects and Adverse Reactions. Female. Humans. Linear Models. Lip / physiology. Male. Mastication / physiology. Salivary Glands / drug effects. Salivary Glands / physiology. Sex Factors

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  • [Copyright] © 2010 John Wiley & Sons A/S.
  • (PMID = 20545715.001).
  • [ISSN] 1600-0528
  • [Journal-full-title] Community dentistry and oral epidemiology
  • [ISO-abbreviation] Community Dent Oral Epidemiol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
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75. Al-Bakri AG, Bustanji Y, Yousef AM: Community consumption of antibacterial drugs within the Jordanian population: sources, patterns and appropriateness. Int J Antimicrob Agents; 2005 Nov;26(5):389-95
MedlinePlus Health Information. consumer health - Antibiotics.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Dispensed antibacterial drugs belonged to eight different main classes of systemically used antibacterial drugs in accordance with the Anatomical Therapeutic Chemical (ATC) classification system.
  • [MeSH-major] Anti-Bacterial Agents / therapeutic use

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  • (PMID = 16221541.001).
  • [ISSN] 0924-8579
  • [Journal-full-title] International journal of antimicrobial agents
  • [ISO-abbreviation] Int. J. Antimicrob. Agents
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Nonprescription Drugs
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76. Blix HS, Hartug S: Hospital usage of antibacterial agents in relation to size and type of hospital and geographical situation. Pharmacoepidemiol Drug Saf; 2005 Sep;14(9):647-9
MedlinePlus Health Information. consumer health - Health Facilities.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Drugs were classified according to the ATC classification and the ATC/DDD index 2001 and standardised bed-days were used.
  • However, therapeutic choice of antibacterial agents differs and seems to be influenced by hospital size and hospital type.

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  • [Copyright] (c) 2005 John Wiley & Sons, Ltd.
  • (PMID = 15700320.001).
  • [ISSN] 1053-8569
  • [Journal-full-title] Pharmacoepidemiology and drug safety
  • [ISO-abbreviation] Pharmacoepidemiol Drug Saf
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents
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77. Uchida N, Chong MY, Tan CH, Nagai H, Tanaka M, Lee MS, Fujii S, Yang SY, Si T, Sim K, Wei H, Ling HY, Nishimura R, Kawaguchi Y, Edwards G, Sartorius N, Shinfuku N: International study on antidepressant prescription pattern at 20 teaching hospitals and major psychiatric institutions in East Asia: Analysis of 1898 cases from China, Japan, Korea, Singapore and Taiwan. Psychiatry Clin Neurosci; 2007 Oct;61(5):522-8
MedlinePlus Health Information. consumer health - Antidepressants.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Out of 56 antidepressants listed in the Anatomical Therapeutic Chemical Classification (ATC) index by the World Health Organization (WHO) Collaborating Center for Drug Statistics Methodology (Oslo), only 26 antidepressants were prescribed in participating countries in East Asia.
  • [MeSH-major] Antidepressive Agents / therapeutic use. Cross-Cultural Comparison. Depressive Disorder / drug therapy. Drug Prescriptions / statistics & numerical data. Hospitals, Psychiatric / statistics & numerical data. Hospitals, Teaching / statistics & numerical data
  • [MeSH-minor] Adult. Antidepressive Agents, Second-Generation / therapeutic use. China. Cross-Sectional Studies. Drug Utilization / statistics & numerical data. Female. Humans. Japan. Korea. Male. Middle Aged. Serotonin Uptake Inhibitors / therapeutic use. Singapore. Taiwan. World Health Organization

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  • (PMID = 17875031.001).
  • [ISSN] 1323-1316
  • [Journal-full-title] Psychiatry and clinical neurosciences
  • [ISO-abbreviation] Psychiatry Clin. Neurosci.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antidepressive Agents; 0 / Antidepressive Agents, Second-Generation; 0 / Serotonin Uptake Inhibitors
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78. Salvatore G, Nappi TC, Salerno P, Jiang Y, Garbi C, Ugolini C, Miccoli P, Basolo F, Castellone MD, Cirafici AM, Melillo RM, Fusco A, Bittner ML, Santoro M: A cell proliferation and chromosomal instability signature in anaplastic thyroid carcinoma. Cancer Res; 2007 Nov 1;67(21):10148-58
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A cell proliferation and chromosomal instability signature in anaplastic thyroid carcinoma.
  • Here, we show that the anaplastic thyroid carcinoma (ATC) features the up-regulation of a set of genes involved in the control of cell cycle progression and chromosome segregation.
  • This phenotype differentiates ATC from normal tissue and from well-differentiated papillary thyroid carcinoma.
  • Transcriptional promoters of the ATC up-regulated genes are characterized by a modular organization featuring binding sites for E2F and NF-Y transcription factors and cell cycle-dependent element (CDE)/cell cycle gene homology region (CHR) cis-regulatory elements.
  • Two protein kinases involved in cell cycle regulation, namely, Polo-like kinase 1 (PLK1) and T cell tyrosine kinase (TTK), are part of the gene set that is up-regulated in ATC.
  • Adoptive overexpression of p53, p21 (CIP1/WAF1), and E2F4 down-regulated transcription from the PLK1 and TTK promoters in ATC cells, suggesting that these genes might be under the negative control of tumor suppressors of the p53 and pRB families.
  • ATC, but not normal thyroid, cells depended on PLK1 for survival.
  • Thus, thyroid cell anaplastic transformation is accompanied by the overexpression of a cell proliferation/genetic instability-related gene cluster that includes PLK1 kinase, which is a potential molecular target for ATC treatment.
  • [MeSH-major] Carcinoma / genetics. Chromosomal Instability. Thyroid Neoplasms / genetics

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  • (PMID = 17981789.001).
  • [ISSN] 1538-7445
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cell Cycle Proteins; 0 / Proto-Oncogene Proteins; 0 / Tumor Suppressor Protein p53; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; EC 2.7.11.1 / polo-like kinase 1; EC 2.7.12.1 / TTK protein, human
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79. Turkdogan FI, Yetilmezsoy K: Appraisal of potential environmental risks associated with human antibiotic consumption in Turkey. J Hazard Mater; 2009 Jul 15;166(1):297-308
MedlinePlus Health Information. consumer health - Antibiotics.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Antibiotics were defined for systemic use or group J01 of the WHO Anatomical Therapeutic Chemical (ATC) classification system.
  • Total emissions and prescriptions for each ATC group were classified separately into 17 different J01 categories and three forms of medication (capsule/tablets, injectables and suspensions).
  • [MeSH-major] Anti-Bacterial Agents / analysis. Water Pollutants, Chemical / analysis

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  • (PMID = 19100684.001).
  • [ISSN] 1873-3336
  • [Journal-full-title] Journal of hazardous materials
  • [ISO-abbreviation] J. Hazard. Mater.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Dosage Forms; 0 / Water Pollutants, Chemical
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80. Wirtz VJ, Dreser A, Gonzales R: Trends in antibiotic utilization in eight Latin American countries, 1997-2007. Rev Panam Salud Publica; 2010 Mar;27(3):219-25
MedlinePlus Health Information. consumer health - Antibiotics.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To describe the trends in antibiotic utilization in eight Latin American countries between 1997-2007 METHODS: We analyzed retail sales data of oral and injectable antibiotics (World Health Organization (WHO) Anatomic Therapeutic Chemical (ATC) code J01) between 1997 and 2007 for Argentina, Brazil, Chile, Colombia, Mexico, Peru, Uruguay, and Venezuela.
  • The kilogram sales of each antibiotic were converted into defined daily dose per 1 000 inhabitants per day (DID) according to the WHO ATC classification system.
  • [MeSH-major] Anti-Bacterial Agents / therapeutic use

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  • (PMID = 20414511.001).
  • [ISSN] 1680-5348
  • [Journal-full-title] Revista panamericana de salud pública = Pan American journal of public health
  • [ISO-abbreviation] Rev. Panam. Salud Publica
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents
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81. Deters M, Prasa D, Hentschel H, Schaper A: Iatrogenic intravenous medication errors reported to the GIZ-Nord Poisons Center Göttingen. Eur J Intern Med; 2009 Nov;20(7):728-31
Hazardous Substances Data Bank. THEOPHYLLINE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The drug classes (ATC classification) involved most frequently were antipsychotics (7.9%) and antithrombotic agents (6.0%).
  • [MeSH-major] Iatrogenic Disease / epidemiology. Medication Errors / statistics & numerical data. Poison Control Centers / statistics & numerical data

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  • (PMID = 19818296.001).
  • [ISSN] 1879-0828
  • [Journal-full-title] European journal of internal medicine
  • [ISO-abbreviation] Eur. J. Intern. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antipsychotic Agents; 0 / Bronchodilator Agents; C137DTR5RG / Theophylline
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82. Sakji S, Letord C, Pereira S, Dahamna B, Joubert M, Darmoni J: Drug information portal in Europe: information retrieval with multiple health terminologies. Stud Health Technol Inform; 2009;150:497-501
MedlinePlus Health Information. consumer health - Medicines.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • DIP has created specific functionalities related to drug and used specific drugs terminologies and classifications: the ATC classification, the CAS numbers, the French codes CIS, and CIP, as well as trade names and the International Nonproprietary Names of the drugs.

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  • (PMID = 19745361.001).
  • [ISSN] 0926-9630
  • [Journal-full-title] Studies in health technology and informatics
  • [ISO-abbreviation] Stud Health Technol Inform
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Pharmaceutical Preparations
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83. Jakimavicius M, Sveikata A, Vainauskas P, Jankūnas R, Mikucionyte L, Sapoliene A, Smigelskas K: Analysis of antidepressant prescribing tendencies in Lithuania in 2003-2004. Medicina (Kaunas); 2007;43(5):412-8
MedlinePlus Health Information. consumer health - Depression.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Antidepressants were classified into three groups according to Anatomic Therapeutic Chemical (ATC) Classification specifying the defined daily doses.
  • Additional studies should be carried out in order to assess drug-prescribing patterns in accordance with the guidelines of depression treatment in Lithuania considering diagnosis, dosage, and duration of treatment.
  • [MeSH-major] Antidepressive Agents / therapeutic use. Depression / drug therapy. Drug Prescriptions / statistics & numerical data
  • [MeSH-minor] Adult. Age Factors. Aged. Antidepressive Agents, Second-Generation / administration & dosage. Antidepressive Agents, Second-Generation / economics. Antidepressive Agents, Second-Generation / therapeutic use. Antidepressive Agents, Tricyclic / administration & dosage. Antidepressive Agents, Tricyclic / economics. Antidepressive Agents, Tricyclic / therapeutic use. Female. Humans. Insurance, Health, Reimbursement. Lithuania. Male. Middle Aged. Serotonin Uptake Inhibitors / administration & dosage. Serotonin Uptake Inhibitors / economics. Serotonin Uptake Inhibitors / therapeutic use. Time Factors

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  • (PMID = 17563418.001).
  • [ISSN] 1648-9144
  • [Journal-full-title] Medicina (Kaunas, Lithuania)
  • [ISO-abbreviation] Medicina (Kaunas)
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] Lithuania
  • [Chemical-registry-number] 0 / Antidepressive Agents; 0 / Antidepressive Agents, Second-Generation; 0 / Antidepressive Agents, Tricyclic; 0 / Serotonin Uptake Inhibitors
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84. Visone R, Pallante P, Vecchione A, Cirombella R, Ferracin M, Ferraro A, Volinia S, Coluzzi S, Leone V, Borbone E, Liu CG, Petrocca F, Troncone G, Calin GA, Scarpa A, Colato C, Tallini G, Santoro M, Croce CM, Fusco A: Specific microRNAs are downregulated in human thyroid anaplastic carcinomas. Oncogene; 2007 Nov 29;26(54):7590-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Specific microRNAs are downregulated in human thyroid anaplastic carcinomas.
  • Thyroid carcinomas comprise a broad spectrum of tumors with different clinical behaviors.
  • On the one side, there are occult papillary carcinomas (PTC), slow growing and clinically silent, and on the other side, rapidly growing anaplastic carcinomas (ATC), which are among the most lethal human neoplasms.
  • We have analysed the microRNA (miR) profile of ATC in comparison to the normal thyroid using a microarray (miRNACHIP microarray).
  • By this approach, we found an aberrant miR expression profile that clearly differentiates ATC from normal thyroid tissues and from PTC analysed in previous studies.
  • In particular, a significant decrease in miR-30d, miR-125b, miR-26a and miR-30a-5p was detected in ATC in comparison to normal thyroid tissue.
  • The overexpression of these four miRs in two human ATC-derived cell lines suggests a critical role of miR-125b and miR-26a downregulation in thyroid carcinogenesis, since a cell growth inhibition was achieved.
  • In conclusion, these data indicate a miR signature associated with ATC and suggest the miR deregulation as an important event in thyroid cell transformation.
  • [MeSH-major] Carcinoma / genetics. Chromosome Mapping. Gene Expression Regulation. MicroRNAs / genetics. Thyroid Neoplasms / genetics
  • [MeSH-minor] Cell Transformation, Neoplastic. Chromosomes, Human. Humans. RNA, Neoplasm / genetics. Reference Values. Thyroid Gland / physiology

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  • (PMID = 17563749.001).
  • [ISSN] 1476-5594
  • [Journal-full-title] Oncogene
  • [ISO-abbreviation] Oncogene
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / MIRN510 microRNA, human; 0 / MicroRNAs; 0 / RNA, Neoplasm
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85. Decoster LC, Swartz EE, Cappaert TA, Hootman JM: Prevalence and characteristics of general and football-specific emergency medical service activations by high school and collegiate certified athletic trainers: a national study. Clin J Sport Med; 2010 Nov;20(6):436-44
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prevalence and characteristics of general and football-specific emergency medical service activations by high school and collegiate certified athletic trainers: a national study.
  • OBJECTIVE: To describe frequency and characteristics of emergency medical services (EMS) activations by certified athletic trainers (ATs) and effects of pre-season planning meetings on interactions between ATs and EMS both generally and specifically during football head/neck emergencies.
  • PARTICIPANTS: Athletic trainers (n = 1884; participation rate, 28%) in high school and collegiate settings.
  • INDEPENDENT VARIABLES: Athletic trainer work setting, AT demographics, history of pre-season planning meetings.
  • CONCLUSIONS: Athletic trainer-EMS interactions are common and sometimes involve AT-perceived episodes of inappropriate care and on-field disagreements between emergency care providers.


86. Masago K, Fujita S, Irisa K, Kim YH, Ichikawa M, Mio T, Mishima M: Good clinical response to gefitinib in a non-small cell lung cancer patient harboring a rare somatic epidermal growth factor gene point mutation; codon 768 AGC &gt; ATC in exon 20 (S768I). Jpn J Clin Oncol; 2010 Nov;40(11):1105-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Good clinical response to gefitinib in a non-small cell lung cancer patient harboring a rare somatic epidermal growth factor gene point mutation; codon 768 AGC > ATC in exon 20 (S768I).
  • Recently, two small-molecule kinase inhibitors targeting epidermal growth factor receptor have proven effective in the treatment of non-small cell lung cancer.
  • We reported a case of non-small cell lung cancer harboring a rare epidermal growth factor somatic mutation, codon 768 AGC > ATC in exon 20 (S768I), who showed a good clinical response to gefitinib.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Lung Neoplasms / drug therapy. Lung Neoplasms / genetics. Point Mutation / genetics. Quinazolines / therapeutic use. Receptor, Epidermal Growth Factor / genetics
  • [MeSH-minor] Aged, 80 and over. Carcinoma, Non-Small-Cell Lung / drug therapy. Carcinoma, Non-Small-Cell Lung / genetics. Carcinoma, Non-Small-Cell Lung / pathology. Exons / genetics. Humans. Male. Prognosis


87. Nijk RM, Zuidema SU, Koopmans RT: Prevalence and correlates of psychotropic drug use in Dutch nursing-home patients with dementia. Int Psychogeriatr; 2009 Jun;21(3):485-93
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  • Drugs were categorized according to the Anatomical Therapeutical Chemical classification (ATC).

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  • (PMID = 19368752.001).
  • [ISSN] 1041-6102
  • [Journal-full-title] International psychogeriatrics
  • [ISO-abbreviation] Int Psychogeriatr
  • [Language] ENG
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Anxiety Agents; 0 / Antidepressive Agents; 0 / Antipsychotic Agents; 0 / Hypnotics and Sedatives; 0 / Psychotropic Drugs
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88. Deters M, Prasa D, Hentschel H, Schaper A: Iatrogenic intravenous medication errors reported to the PIC Erfurt. Clin Toxicol (Phila); 2009 Feb;47(2):169-73
MedlinePlus Health Information. consumer health - Medication Errors.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The drug classes (ATC classification) involved most frequently were antipsychotics (9.8%) and antihistamines for systemic use (7.5%).
  • [MeSH-major] Iatrogenic Disease / epidemiology. Medication Errors. Poison Control Centers

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  • (PMID = 18608299.001).
  • [ISSN] 1556-9519
  • [Journal-full-title] Clinical toxicology (Philadelphia, Pa.)
  • [ISO-abbreviation] Clin Toxicol (Phila)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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89. Cariou JL: [Social and anthropology considerations on the composite tissues allotransplantations (CTA). Excerpts from reading and analysis of a surgeon]. Ann Chir Plast Esthet; 2007 Oct;52(5):524-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Considérations socioanthropologiques sur les allotransplantations de tissus composites (ATC). Extraits de lecture et analyse d'un chirurgien.

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  • (PMID = 17719714.001).
  • [ISSN] 0294-1260
  • [Journal-full-title] Annales de chirurgie plastique et esthétique
  • [ISO-abbreviation] Ann Chir Plast Esthet
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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90. Pacifico F, Crescenzi E, Mellone S, Iannetti A, Porrino N, Liguoro D, Moscato F, Grieco M, Formisano S, Leonardi A: Nuclear factor-{kappa}B contributes to anaplastic thyroid carcinomas through up-regulation of miR-146a. J Clin Endocrinol Metab; 2010 Mar;95(3):1421-30
MedlinePlus Health Information. consumer health - Thyroid Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nuclear factor-{kappa}B contributes to anaplastic thyroid carcinomas through up-regulation of miR-146a.
  • CONTEXT: Micro-RNAs (miRNAs) have been recently involved in the modulation of several biological activities including cancer.
  • Many human tumors show deregulated expression of miRNAs targeting oncogenes and/or tumor suppressors, thus identifying miRNAs as new molecular targets for cancer therapy.
  • OBJECTIVES: Nuclear factor (NF)-kappaB is strongly activated in human anaplastic thyroid carcinomas (ATCs).
  • Because the regulation of miRNA expression is under control of RNA polymerase II-dependent transcription factors, we stably inactivated NF-kappaB in the ATC-derived FRO cell line and analyzed its miRNA profile in comparison with the parental counterpart by using a miRNA chip microarray.
  • Importantly, the miR-146a resulted in overexpression of human ATC specimens compared with the normal thyroid tissue.
  • CONCLUSIONS: Our results show that NF-kappaB contributes to anaplastic thyroid cancer up-regulating the expression of miR-146a.
  • [MeSH-major] Carcinoma / genetics. MicroRNAs / genetics. NF-kappa B / genetics. Thyroid Neoplasms / genetics. Up-Regulation / genetics

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  • (PMID = 20061417.001).
  • [ISSN] 1945-7197
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / MIRN146 microRNA, human; 0 / MicroRNAs; 0 / NF-kappa B
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91. Kopjar N, Zeljezić D, Kasuba V, Rozgaj R: [Antineoplastic drugs as a potential risk factor in occupational settings: mechanisms of action at the cell level, genotoxic effects, and their detection using different biomarkers]. Arh Hig Rada Toksikol; 2010 Mar;61(1):121-46
MedlinePlus Health Information. consumer health - Occupational Health.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Classification of antineoplastic drugs according to the IARC monographs on the evaluation of carcinogenic risks to humans is accompanied by data on their mutagenicity and the most recent updates in the Anatomical Therapeutic Chemical (ATC) Classification System.

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  • (PMID = 20338875.001).
  • [ISSN] 0004-1254
  • [Journal-full-title] Arhiv za higijenu rada i toksikologiju
  • [ISO-abbreviation] Arh Hig Rada Toksikol
  • [Language] hrv
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Croatia
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 212
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92. Are C, Shaha AR: Anaplastic thyroid carcinoma: biology, pathogenesis, prognostic factors, and treatment approaches. Ann Surg Oncol; 2006 Apr;13(4):453-64
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anaplastic thyroid carcinoma: biology, pathogenesis, prognostic factors, and treatment approaches.
  • BACKGROUND: Anaplastic thyroid carcinoma (ATC) is one of the most aggressive solid tumors known to affect humans and carries a dismal prognosis.
  • We also reviewed the individual and combined roles of surgery, radiotherapy, chemotherapy, and newer therapeutic options in the management of ATC.
  • METHODS: An extensive literature review was conducted to include all published reports on ATC.
  • The changing trends in the management of anaplastic thyroid cancer were analyzed to summarize the current practice of management of ATC.
  • RESULTS: Although ATC is rare, there has been a decline in its incidence worldwide.
  • ATC accounts for more than half of the 1200 deaths per year attributed to thyroid cancer.
  • Long-term survivors are rare, with >75% and 50% of patients harboring cervical nodal disease and metastatic disease, respectively, at presentation.
  • ATC can arise de novo or from preexisting well-differentiated thyroid cancer.
  • CONCLUSIONS: Despite multimodality approaches, ATC still carries a dismal prognosis.
  • This should provoke innovative strategies beyond conventional methods to tackle this uniformly lethal disease.
  • [MeSH-major] Carcinoma / therapy. Thyroid Neoplasms / therapy

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  • (PMID = 16474910.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 126
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93. de With K, Meyer E, Steib-Bauert M, Schwab F, Daschner FD, Kern WV: Antibiotic use in two cohorts of German intensive care units. J Hosp Infect; 2006 Nov;64(3):231-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • These were the World Health Organization/Anatomical Therapeutic Chemical Classification (ATC) 2001 definition of defined daily dose (DDD), and a definition of recommended daily dose (RDD) that better reflected the currently prescribed dosages of parenteral drugs for hospitalized patients.
  • [MeSH-major] Anti-Bacterial Agents / therapeutic use. Drug Utilization Review. Intensive Care Units / statistics & numerical data. Pharmacoepidemiology

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  • (PMID = 16891039.001).
  • [ISSN] 0195-6701
  • [Journal-full-title] The Journal of hospital infection
  • [ISO-abbreviation] J. Hosp. Infect.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents
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94. Masquelet AC: [Philosophical and ethics aspects of the composite tissues allotransplantations (CTA)]. Ann Chir Plast Esthet; 2007 Oct;52(5):519-23

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Aspects éthicophilosophiques des allotransplantations de tissus composites (ATC).

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  • (PMID = 17719712.001).
  • [ISSN] 0294-1260
  • [Journal-full-title] Annales de chirurgie plastique et esthétique
  • [ISO-abbreviation] Ann Chir Plast Esthet
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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95. Pohjanoksa-Mäntylä MK, Antila J, Eerikäinen S, Enäkoski M, Hannuksela O, Pietilä K, Airaksinen M: Utilization of a community pharmacy-operated national drug information call center in Finland. Res Social Adm Pharm; 2008 Jun;4(2):144-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The majority (83%) of these calls were therapeutic or pharmaceutical inquiries, with 26% concerning costs and reimbursements, 14% interactions, 14% dosages, and 11% adverse effects.
  • Nervous system drugs (Anatomical Therapeutic Chemical [ATC] classification N), anti-infectives (J), and musculoskeletal drugs (M) accounted for 20%, 18%, and 13% of the calls, respectively.
  • Nonsteroidal anti-inflammatory drugs (NSAID) (9% of the calls), antidepressants (6%), and penicillin (5%) were the most often inquired about ATC-subgroups.
  • This may especially be the case for certain population groups, and in regard to nervous system drugs, anti-infectives and NSAID.

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  • (PMID = 18555967.001).
  • [ISSN] 1551-7411
  • [Journal-full-title] Research in social & administrative pharmacy : RSAP
  • [ISO-abbreviation] Res Social Adm Pharm
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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96. Pudney D, Lau H, Ruether JD, Falck V: Clinical experience of the multimodality management of anaplastic thyroid cancer and literature review. Thyroid; 2007 Dec;17(12):1243-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical experience of the multimodality management of anaplastic thyroid cancer and literature review.
  • Anaplastic Thyroid Carcinoma (ATC) is a rare thyroid tumor with a very aggressive clinical course.
  • The following is a report of five patients with inoperable locally advanced disease treated at our institution using multimodality management consisting of chemotherapy and hyperfractionated accelerated radiotherapy.
  • A flow diagram with management recommendations for inoperable ATC is suggested.
  • [MeSH-major] Carcinoma / therapy. Thyroid Neoplasms / therapy
  • [MeSH-minor] Combined Modality Therapy. Disease Progression. Female. Humans. Male. Treatment Outcome

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  • (PMID = 18177257.001).
  • [ISSN] 1050-7256
  • [Journal-full-title] Thyroid : official journal of the American Thyroid Association
  • [ISO-abbreviation] Thyroid
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 44
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97. Libertini S, Iacuzzo I, Ferraro A, Vitale M, Bifulco M, Fusco A, Portella G: Lovastatin enhances the replication of the oncolytic adenovirus dl1520 and its antineoplastic activity against anaplastic thyroid carcinoma cells. Endocrinology; 2007 Nov;148(11):5186-94
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Lovastatin enhances the replication of the oncolytic adenovirus dl1520 and its antineoplastic activity against anaplastic thyroid carcinoma cells.
  • Anaplastic thyroid carcinoma (ATC) is one of the most aggressive solid tumors and shows morphological features of a highly malignant, undifferentiated neoplasm.
  • Patients with ATC have a poor prognosis with a mean survival time of 2-6 months; surgery, radiotherapy, and chemotherapy do not improve survival.
  • Gene therapy approaches and oncolytic viruses have been tested for the treatment of ATC.
  • To enhance the antineoplastic effects of the oncolytic adenovirus dl1520 (Onyx-015), we treated ATC cells with lovastatin (3-hydroxy-methylglutaryl-CoA reductase inhibitor), a drug used for the treatment of hypercholesterolemia, which has previously been reported to exert growth-inhibitory and apoptotic activity on ATC cells.
  • Lovastatin treatment significantly increased the effects of dl1520 against ATC cells.
  • The replication of dl1520 in ATC cells was enhanced by lovastatin treatment, and a significant increase of the expression of the early gene E1A 13 S and the late gene Penton was observed in lovastatin-treated cells.
  • Furthermore, lovastatin treatment significantly enhanced the effects of dl1520 against ATC tumor xenografts.
  • Lovastatin treatment could be exploited to increase the efficacy of oncolytic adenoviruses, and further studies are warranted to confirm the feasibility of the approach in ATC patients.
  • [MeSH-major] Adenoviridae / drug effects. Antineoplastic Agents / therapeutic use. Carcinoma / therapy. Lovastatin / pharmacology. Lovastatin / therapeutic use. Oncolytic Virotherapy. Thyroid Neoplasms / therapy. Virus Replication / drug effects

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  • Hazardous Substances Data Bank. LOVASTATIN .
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  • (PMID = 17690162.001).
  • [ISSN] 0013-7227
  • [Journal-full-title] Endocrinology
  • [ISO-abbreviation] Endocrinology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / ONYX015; 0 / Viral Vaccines; 9LHU78OQFD / Lovastatin
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98. Dumartin C, L'Hériteau F, Péfau M, Bertrand X, Jarno P, Boussat S, Angora P, Lacavé L, Saby K, Savey A, Nguyen F, Carbonne A, Rogues AM: Antibiotic use in 530 French hospitals: results from a surveillance network at hospital and ward levels in 2007. J Antimicrob Chemother; 2010 Sep;65(9):2028-36
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Data were voluntarily collected retrospectively by 530 hospitals accounting for approximately 40 million patient-days (PD) on the following: antibacterials for systemic use [J01 class of the WHO Anatomical Therapeutic Chemical (ATC) classification, defined daily doses (DDD) system, 2007], rifampicin and oral imidazole derivatives, expressed in number of DDD and number of PD in 2007.
  • Penicillins and beta-lactamase inhibitors combinations were the most frequently used antibiotics, accounting for 26% of total use in cancer hospitals to 40% in LTC/psychiatric hospitals.
  • Glycopeptides and carbapenems were mostly used in cancer and teaching hospitals.
  • [MeSH-major] Anti-Bacterial Agents / therapeutic use. Drug Utilization / statistics & numerical data

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  • (PMID = 20581121.001).
  • [ISSN] 1460-2091
  • [Journal-full-title] The Journal of antimicrobial chemotherapy
  • [ISO-abbreviation] J. Antimicrob. Chemother.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents
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99. Elseviers MM, Ferech M, Vander Stichele RH, Goossens H, ESAC project group: Antibiotic use in ambulatory care in Europe (ESAC data 1997-2002): trends, regional differences and seasonal fluctuations. Pharmacoepidemiol Drug Saf; 2007 Jan;16(1):115-23
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Valid data of antibiotic consumption of 24 European countries for 2002 and of 18 countries for the entire 6-year period was classified according to the Anatomical Therapeutic Chemical Classification (ATC) and expressed in defined daily dose (DDD) per 1000 inhabitants per day (DID).
  • [MeSH-major] Ambulatory Care / methods. Ambulatory Care / statistics & numerical data. Anti-Bacterial Agents / therapeutic use. Drug Utilization Review / statistics & numerical data. Seasons
  • [MeSH-minor] Cephalosporins / therapeutic use. Drug Utilization / statistics & numerical data. Europe. Humans. Penicillins / therapeutic use. Pharmacoepidemiology / methods. Practice Patterns, Physicians' / statistics & numerical data. Quinolones / therapeutic use. Retrospective Studies. Streptogramins / therapeutic use. Time Factors

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  • [Copyright] Copyright (c) 2006 John Wiley & Sons, Ltd.
  • (PMID = 16700079.001).
  • [ISSN] 1053-8569
  • [Journal-full-title] Pharmacoepidemiology and drug safety
  • [ISO-abbreviation] Pharmacoepidemiol Drug Saf
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Cephalosporins; 0 / Penicillins; 0 / Quinolones; 0 / Streptogramins
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100. Takarabe M, Okuda S, Itoh M, Tokimatsu T, Goto S, Kanehisa M: Network analysis of adverse drug interactions. Genome Inform; 2008;20:252-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We defined drug target and drug-metabolizing enzymes as interaction factors using information on them in KEGG DRUG, and classified drugs into pharmacological/chemical subgroups.
  • To characterize other interactions without interaction factors, we used the ATC classification system and found an association between interaction mechanisms and pharmacological/chemical subgroups.

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  • (PMID = 19425139.001).
  • [ISSN] 0919-9454
  • [Journal-full-title] Genome informatics. International Conference on Genome Informatics
  • [ISO-abbreviation] Genome Inform
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Pharmaceutical Preparations; 0 / Receptors, Biogenic Amine; EC 1.14.14.1 / Cytochrome P-450 CYP3A
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